sgfin commited on
Commit
e0128c0
·
verified ·
1 Parent(s): 06adf10

Update sample_questions.json

Browse files

Rename `clinical_info` to `clinical_context`

Files changed (1) hide show
  1. sample_questions.json +16 -16
sample_questions.json CHANGED
@@ -11,7 +11,7 @@
11
  "zygosity": "hemizygous"
12
  }
13
  ],
14
- "clinical_info": "Progressive muscle weakness"
15
  },
16
  "question": "To which of the following targeted therapies would this variant be most likely amenable: Golodirsen, Viltolarsen, Eteplirsen, Casimersen, Ataluren, or None?",
17
  "answer": "Eteplirsen",
@@ -32,7 +32,7 @@
32
  "zygosity": "hemizygous"
33
  }
34
  ],
35
- "clinical_info": "Progressive muscle weakness"
36
  },
37
  "question": "To which of the following targeted therapies would this variant be most likely amenable: Golodirsen, Viltolarsen, Eteplirsen, Casimersen, Ataluren, or None?",
38
  "answer": "Ataluren",
@@ -53,7 +53,7 @@
53
  "zygosity": "hemizygous"
54
  }
55
  ],
56
- "clinical_info": "Progressive muscle weakness"
57
  },
58
  "question": "To which of the following targeted therapies would this variant be most likely amenable: Eteplirsen, Golodirsen, Viltolarsen, Casimersen, Ataluren, or None?",
59
  "answer": "None",
@@ -74,7 +74,7 @@
74
  "zygosity": "homozygous"
75
  }
76
  ],
77
- "clinical_info": "Recurrent nephrocalcinosis and chronic kidney disease"
78
  },
79
  "question": "What targeted, small molecule therapy is available for this patient? Provide the generic name or None.",
80
  "answer": "Pyridoxine",
@@ -95,7 +95,7 @@
95
  "zygosity": "homozygous"
96
  }
97
  ],
98
- "clinical_info": "Recurrent nephrocalcinosis and chronic kidney disease"
99
  },
100
  "question": "Is this patient predicted to be responsive to pyridoxine? Answer yes or no.",
101
  "answer": "No",
@@ -116,7 +116,7 @@
116
  "zygosity": "homozygous"
117
  }
118
  ],
119
- "clinical_info": "7 year old with recurrent nephrocalcinosis and chronic kidney disease"
120
  },
121
  "question": "What targeted, genetic therapies are approved for this patient in the US? Provide the generic name.",
122
  "answer": "Lumasiran",
@@ -137,7 +137,7 @@
137
  "zygosity": "homozygous"
138
  }
139
  ],
140
- "clinical_info": "Global developmental delay"
141
  },
142
  "question": "What is the youngest age for which a gene therapy is approved for this patient's genetic condition in the united kingdom? Answer with the format \"X months\".",
143
  "answer": "18 months",
@@ -158,7 +158,7 @@
158
  "zygosity": "heterozygous"
159
  }
160
  ],
161
- "clinical_info": "joint hypermobility, skin hyperextensibility, and easy bruising"
162
  },
163
  "question": "What two medications are most established for decreasing bruising? List generic names in alphabetical order",
164
  "answer": "ascorbic acid, desmopressin",
@@ -179,7 +179,7 @@
179
  "zygosity": "heterozygous"
180
  }
181
  ],
182
- "clinical_info": "Patient with SLC35A2-CDG who is experiencing seizures and global developmental delay"
183
  },
184
  "question": "What clinical trial developing a new therapeutic for this condition is recruiting or listed as upcoming/not yet recruiting? Return a clinical trials ID",
185
  "answer": "NCT05402384",
@@ -200,7 +200,7 @@
200
  "zygosity": "heterozygous"
201
  }
202
  ],
203
- "clinical_info": "seizures and global developmental delay. Age 2 months, Hemoglobin 5, Normal liver labs, Not enrolled in other trials"
204
  },
205
  "question": "Is this patient eligible for clinical trial NCT05402384? Answer yes or no.",
206
  "answer": "No",
@@ -221,7 +221,7 @@
221
  "zygosity": "heterozygous"
222
  }
223
  ],
224
- "clinical_info": "early-onset seizures and developmental delays"
225
  },
226
  "question": "For which clinical trials evaluating new therapeutics is this patient eligible? Provide a clinical trial ID or answer None.",
227
  "answer": "None",
@@ -242,7 +242,7 @@
242
  "zygosity": "heterozygous"
243
  }
244
  ],
245
- "clinical_info": "intellectual disability, seizures, and developmental delays"
246
  },
247
  "question": "Is it more likely amenable to treatment with Memantine, L-serine, or Radiprodil",
248
  "answer": "L-Serine",
@@ -263,7 +263,7 @@
263
  "zygosity": "homozygous"
264
  }
265
  ],
266
- "clinical_info": "progressive cerebellar ataxia and peripheral neuropathy"
267
  },
268
  "question": "How many amino acids are coded for by the exon in which this variant occurs? Answer with a number",
269
  "answer": "66",
@@ -284,7 +284,7 @@
284
  "zygosity": "homozygous"
285
  }
286
  ],
287
- "clinical_info": "progressive cerebellar ataxia and peripheral neuropathy"
288
  },
289
  "question": "What percentage of the total coding transcript for this gene are encoded by the exon in which this variant occurs? Answer with a decimal to nearest tenth.",
290
  "answer": "0.1",
@@ -305,7 +305,7 @@
305
  "zygosity": "heterozygous"
306
  }
307
  ],
308
- "clinical_info": "childhood-onset generalized dystonia"
309
  },
310
  "question": "Based on typical prediction rules, is this variant likely to result in nonsense mediated decay? Answer yes or no.",
311
  "answer": "No",
@@ -326,7 +326,7 @@
326
  "zygosity": "heterozygous"
327
  }
328
  ],
329
- "clinical_info": "Malignant Peripheral Nerve Sheath Tumor and Pheochromocytoma"
330
  },
331
  "question": "In which functional domain does this variant occur? Answer choices: CSRD, TBD, GRD, Sec14-PH, HLR, NLS, SBR.",
332
  "answer": "GRD",
 
11
  "zygosity": "hemizygous"
12
  }
13
  ],
14
+ "clinical_context": "Progressive muscle weakness"
15
  },
16
  "question": "To which of the following targeted therapies would this variant be most likely amenable: Golodirsen, Viltolarsen, Eteplirsen, Casimersen, Ataluren, or None?",
17
  "answer": "Eteplirsen",
 
32
  "zygosity": "hemizygous"
33
  }
34
  ],
35
+ "clinical_context": "Progressive muscle weakness"
36
  },
37
  "question": "To which of the following targeted therapies would this variant be most likely amenable: Golodirsen, Viltolarsen, Eteplirsen, Casimersen, Ataluren, or None?",
38
  "answer": "Ataluren",
 
53
  "zygosity": "hemizygous"
54
  }
55
  ],
56
+ "clinical_context": "Progressive muscle weakness"
57
  },
58
  "question": "To which of the following targeted therapies would this variant be most likely amenable: Eteplirsen, Golodirsen, Viltolarsen, Casimersen, Ataluren, or None?",
59
  "answer": "None",
 
74
  "zygosity": "homozygous"
75
  }
76
  ],
77
+ "clinical_context": "Recurrent nephrocalcinosis and chronic kidney disease"
78
  },
79
  "question": "What targeted, small molecule therapy is available for this patient? Provide the generic name or None.",
80
  "answer": "Pyridoxine",
 
95
  "zygosity": "homozygous"
96
  }
97
  ],
98
+ "clinical_context": "Recurrent nephrocalcinosis and chronic kidney disease"
99
  },
100
  "question": "Is this patient predicted to be responsive to pyridoxine? Answer yes or no.",
101
  "answer": "No",
 
116
  "zygosity": "homozygous"
117
  }
118
  ],
119
+ "clinical_context": "7 year old with recurrent nephrocalcinosis and chronic kidney disease"
120
  },
121
  "question": "What targeted, genetic therapies are approved for this patient in the US? Provide the generic name.",
122
  "answer": "Lumasiran",
 
137
  "zygosity": "homozygous"
138
  }
139
  ],
140
+ "clinical_context": "Global developmental delay"
141
  },
142
  "question": "What is the youngest age for which a gene therapy is approved for this patient's genetic condition in the united kingdom? Answer with the format \"X months\".",
143
  "answer": "18 months",
 
158
  "zygosity": "heterozygous"
159
  }
160
  ],
161
+ "clinical_context": "joint hypermobility, skin hyperextensibility, and easy bruising"
162
  },
163
  "question": "What two medications are most established for decreasing bruising? List generic names in alphabetical order",
164
  "answer": "ascorbic acid, desmopressin",
 
179
  "zygosity": "heterozygous"
180
  }
181
  ],
182
+ "clinical_context": "Patient with SLC35A2-CDG who is experiencing seizures and global developmental delay"
183
  },
184
  "question": "What clinical trial developing a new therapeutic for this condition is recruiting or listed as upcoming/not yet recruiting? Return a clinical trials ID",
185
  "answer": "NCT05402384",
 
200
  "zygosity": "heterozygous"
201
  }
202
  ],
203
+ "clinical_context": "seizures and global developmental delay. Age 2 months, Hemoglobin 5, Normal liver labs, Not enrolled in other trials"
204
  },
205
  "question": "Is this patient eligible for clinical trial NCT05402384? Answer yes or no.",
206
  "answer": "No",
 
221
  "zygosity": "heterozygous"
222
  }
223
  ],
224
+ "clinical_context": "early-onset seizures and developmental delays"
225
  },
226
  "question": "For which clinical trials evaluating new therapeutics is this patient eligible? Provide a clinical trial ID or answer None.",
227
  "answer": "None",
 
242
  "zygosity": "heterozygous"
243
  }
244
  ],
245
+ "clinical_context": "intellectual disability, seizures, and developmental delays"
246
  },
247
  "question": "Is it more likely amenable to treatment with Memantine, L-serine, or Radiprodil",
248
  "answer": "L-Serine",
 
263
  "zygosity": "homozygous"
264
  }
265
  ],
266
+ "clinical_context": "progressive cerebellar ataxia and peripheral neuropathy"
267
  },
268
  "question": "How many amino acids are coded for by the exon in which this variant occurs? Answer with a number",
269
  "answer": "66",
 
284
  "zygosity": "homozygous"
285
  }
286
  ],
287
+ "clinical_context": "progressive cerebellar ataxia and peripheral neuropathy"
288
  },
289
  "question": "What percentage of the total coding transcript for this gene are encoded by the exon in which this variant occurs? Answer with a decimal to nearest tenth.",
290
  "answer": "0.1",
 
305
  "zygosity": "heterozygous"
306
  }
307
  ],
308
+ "clinical_context": "childhood-onset generalized dystonia"
309
  },
310
  "question": "Based on typical prediction rules, is this variant likely to result in nonsense mediated decay? Answer yes or no.",
311
  "answer": "No",
 
326
  "zygosity": "heterozygous"
327
  }
328
  ],
329
+ "clinical_context": "Malignant Peripheral Nerve Sheath Tumor and Pheochromocytoma"
330
  },
331
  "question": "In which functional domain does this variant occur? Answer choices: CSRD, TBD, GRD, Sec14-PH, HLR, NLS, SBR.",
332
  "answer": "GRD",