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Aug 12

Biomed-Enriched: A Biomedical Dataset Enriched with LLMs for Pretraining and Extracting Rare and Hidden Content

We introduce Biomed-Enriched, a biomedical text dataset constructed from PubMed via a two-stage annotation process. In the first stage, a large language model annotates 400K paragraphs from PubMed scientific articles, assigning scores for their type (review, study, clinical case, other), domain (clinical, biomedical, other), and educational quality. The educational quality score (rated 1 to 5) estimates how useful a paragraph is for college-level learning. These annotations are then used to fine-tune a small language model, which propagates the labels across the full PMC-OA corpus. The resulting metadata allows us to extract refined subsets, including 2M clinical case paragraphs with over 450K high-quality ones from articles with commercial-use licenses, and to construct several variants via quality filtering and domain upsampling. Clinical text is typically difficult to access due to privacy constraints, as hospital records cannot be publicly shared. Hence, our dataset provides an alternative large-scale, openly available collection of clinical cases from PubMed, making it a valuable resource for biomedical and clinical NLP. Preliminary continual-pretraining experiments with OLMo2 suggest these curated subsets enable targeted improvements, with clinical upsampling boosting performance by ~5% on MMLU ProfMed and educational quality filtering improving MedQA and MedMCQA by ~1%. Combinations of these techniques led to faster convergence, reaching same performance with a third of training tokens, indicating potential for more efficient and effective biomedical pretraining strategies.

ALOcc: Adaptive Lifting-based 3D Semantic Occupancy and Cost Volume-based Flow Prediction

Vision-based semantic occupancy and flow prediction plays a crucial role in providing spatiotemporal cues for real-world tasks, such as autonomous driving. Existing methods prioritize higher accuracy to cater to the demands of these tasks. In this work, we strive to improve performance by introducing a series of targeted improvements for 3D semantic occupancy prediction and flow estimation. First, we introduce an occlusion-aware adaptive lifting mechanism with a depth denoising technique to improve the robustness of 2D-to-3D feature transformation and reduce the reliance on depth priors. Second, we strengthen the semantic consistency between 3D features and their original 2D modalities by utilizing shared semantic prototypes to jointly constrain both 2D and 3D features. This is complemented by confidence- and category-based sampling strategies to tackle long-tail challenges in 3D space. To alleviate the feature encoding burden in the joint prediction of semantics and flow, we propose a BEV cost volume-based prediction method that links flow and semantic features through a cost volume and employs a classification-regression supervision scheme to address the varying flow scales in dynamic scenes. Our purely convolutional architecture framework, named ALOcc, achieves an optimal tradeoff between speed and accuracy achieving state-of-the-art results on multiple benchmarks. On Occ3D and training without the camera visible mask, our ALOcc achieves an absolute gain of 2.5\% in terms of RayIoU while operating at a comparable speed compared to the state-of-the-art, using the same input size (256times704) and ResNet-50 backbone. Our method also achieves 2nd place in the CVPR24 Occupancy and Flow Prediction Competition.

Mixing It Up: The Cocktail Effect of Multi-Task Fine-Tuning on LLM Performance -- A Case Study in Finance

The application of large language models (LLMs) in domain-specific contexts, including finance, has expanded rapidly. Domain-specific LLMs are typically evaluated based on their performance in various downstream tasks relevant to the domain. In this work, we present a detailed analysis of fine-tuning LLMs for such tasks. Somewhat counterintuitively, we find that in domain-specific cases, fine-tuning exclusively on the target task is not always the most effective strategy. Instead, multi-task finetuning - where models are trained on a cocktail of related tasks - can significantly enhance performance. We demonstrate how this approach enables a small model, such as Phi-3-Mini, to achieve state-of-the-art results, even surpassing the much larger GPT-4-o model on financial benchmarks. Our study involves a large-scale experiment, conducting over 200 training experiments using several widely adopted LLMs as baselines, and empirically confirms the benefits of multi-task fine-tuning. Additionally, we explore the use of general instruction data as a form of regularization, suggesting that it helps minimize performance degradation. We also investigate the inclusion of mathematical data, finding improvements in numerical reasoning that transfer effectively to financial tasks. Finally, we note that while fine-tuning for downstream tasks leads to targeted improvements in task performance, it does not necessarily result in broader gains in domain knowledge or complex domain reasoning abilities.

Interpret the Internal States of Recommendation Model with Sparse Autoencoder

Explainable recommendation systems are important to enhance transparency, accuracy, and fairness. Beyond result-level explanations, model-level interpretations can provide valuable insights that allow developers to optimize system designs and implement targeted improvements. However, most current approaches depend on specialized model designs, which often lack generalization capabilities. Given the various kinds of recommendation models, existing methods have limited ability to effectively interpret them. To address this issue, we propose RecSAE, an automatic, generalizable probing method for interpreting the internal states of Recommendation models with Sparse AutoEncoder. RecSAE serves as a plug-in module that does not affect original models during interpretations, while also enabling predictable modifications to their behaviors based on interpretation results. Firstly, we train an autoencoder with sparsity constraints to reconstruct internal activations of recommendation models, making the RecSAE latents more interpretable and monosemantic than the original neuron activations. Secondly, we automated the construction of concept dictionaries based on the relationship between latent activations and input item sequences. Thirdly, RecSAE validates these interpretations by predicting latent activations on new item sequences using the concept dictionary and deriving interpretation confidence scores from precision and recall. We demonstrate RecSAE's effectiveness on two datasets, identifying hundreds of highly interpretable concepts from pure ID-based models. Latent ablation studies further confirm that manipulating latent concepts produces corresponding changes in model output behavior, underscoring RecSAE's utility for both understanding and targeted tuning recommendation models. Code and data are publicly available at https://github.com/Alice1998/RecSAE.

Eureka: Evaluating and Understanding Large Foundation Models

Rigorous and reproducible evaluation is critical for assessing the state of the art and for guiding scientific advances in Artificial Intelligence. Evaluation is challenging in practice due to several reasons, including benchmark saturation, lack of transparency in methods used for measurement, development challenges in extracting measurements for generative tasks, and, more generally, the extensive number of capabilities required for a well-rounded comparison across models. We make three contributions to alleviate the above challenges. First, we present Eureka, an open-source framework for standardizing evaluations of large foundation models beyond single-score reporting and rankings. Second, we introduce Eureka-Bench as an extensible collection of benchmarks testing capabilities that (i) are still challenging for state-of-the-art models and (ii) represent fundamental but overlooked language and multimodal capabilities. The inherent space for improvement in non-saturated benchmarks enables us to discover meaningful differences between models at a capability level. Third, using Eureka, we conduct an analysis of 12 state-of-the-art models, providing in-depth insights into failure understanding and model comparison, which can be leveraged to plan targeted improvements. In contrast to recent trends in reports and leaderboards showing absolute rankings and claims for one model or another to be the best, our analysis shows that there is no such best model. Different models have different strengths, but there are models that appear more often than others as best performers for some capabilities. Despite the recent improvements, current models still struggle with several fundamental capabilities including detailed image understanding, benefiting from multimodal input when available rather than fully relying on language, factuality and grounding for information retrieval, and over refusals.

ArcMMLU: A Library and Information Science Benchmark for Large Language Models

In light of the rapidly evolving capabilities of large language models (LLMs), it becomes imperative to develop rigorous domain-specific evaluation benchmarks to accurately assess their capabilities. In response to this need, this paper introduces ArcMMLU, a specialized benchmark tailored for the Library & Information Science (LIS) domain in Chinese. This benchmark aims to measure the knowledge and reasoning capability of LLMs within four key sub-domains: Archival Science, Data Science, Library Science, and Information Science. Following the format of MMLU/CMMLU, we collected over 6,000 high-quality questions for the compilation of ArcMMLU. This extensive compilation can reflect the diverse nature of the LIS domain and offer a robust foundation for LLM evaluation. Our comprehensive evaluation reveals that while most mainstream LLMs achieve an average accuracy rate above 50% on ArcMMLU, there remains a notable performance gap, suggesting substantial headroom for refinement in LLM capabilities within the LIS domain. Further analysis explores the effectiveness of few-shot examples on model performance and highlights challenging questions where models consistently underperform, providing valuable insights for targeted improvements. ArcMMLU fills a critical gap in LLM evaluations within the Chinese LIS domain and paves the way for future development of LLMs tailored to this specialized area.

Targeted Image Data Augmentation Increases Basic Skills Captioning Robustness

Artificial neural networks typically struggle in generalizing to out-of-context examples. One reason for this limitation is caused by having datasets that incorporate only partial information regarding the potential correlational structure of the world. In this work, we propose TIDA (Targeted Image-editing Data Augmentation), a targeted data augmentation method focused on improving models' human-like abilities (e.g., gender recognition) by filling the correlational structure gap using a text-to-image generative model. More specifically, TIDA identifies specific skills in captions describing images (e.g., the presence of a specific gender in the image), changes the caption (e.g., "woman" to "man"), and then uses a text-to-image model to edit the image in order to match the novel caption (e.g., uniquely changing a woman to a man while maintaining the context identical). Based on the Flickr30K benchmark, we show that, compared with the original data set, a TIDA-enhanced dataset related to gender, color, and counting abilities induces better performance in several image captioning metrics. Furthermore, on top of relying on the classical BLEU metric, we conduct a fine-grained analysis of the improvements of our models against the baseline in different ways. We compared text-to-image generative models and found different behaviors of the image captioning models in terms of encoding visual encoding and textual decoding.

Conditional Data Synthesis Augmentation

Reliable machine learning and statistical analysis rely on diverse, well-distributed training data. However, real-world datasets are often limited in size and exhibit underrepresentation across key subpopulations, leading to biased predictions and reduced performance, particularly in supervised tasks such as classification. To address these challenges, we propose Conditional Data Synthesis Augmentation (CoDSA), a novel framework that leverages generative models, such as diffusion models, to synthesize high-fidelity data for improving model performance across multimodal domains including tabular, textual, and image data. CoDSA generates synthetic samples that faithfully capture the conditional distributions of the original data, with a focus on under-sampled or high-interest regions. Through transfer learning, CoDSA fine-tunes pre-trained generative models to enhance the realism of synthetic data and increase sample density in sparse areas. This process preserves inter-modal relationships, mitigates data imbalance, improves domain adaptation, and boosts generalization. We also introduce a theoretical framework that quantifies the statistical accuracy improvements enabled by CoDSA as a function of synthetic sample volume and targeted region allocation, providing formal guarantees of its effectiveness. Extensive experiments demonstrate that CoDSA consistently outperforms non-adaptive augmentation strategies and state-of-the-art baselines in both supervised and unsupervised settings.

Pensez: Less Data, Better Reasoning -- Rethinking French LLM

Large language models (LLMs) have demonstrated remarkable capabilities in various natural language processing tasks. However, achieving strong performance in specialized domains like mathematical reasoning and non-English languages often requires extensive training on massive datasets. This paper investigates a contrasting approach: strategic fine-tuning on a small, high-quality, bilingual (English-French) dataset to enhance both the reasoning capabilities and French language proficiency of a large language model. Rather than relying on scale, we explore the hypothesis that targeted data curation and optimized training can achieve competitive, or even superior, performance. We demonstrate, through targeted supervised fine-tuning (SFT) on only 2,000 carefully selected samples, significant improvements in mathematical reasoning. Specifically, Pensez 7B exhibits an increase in accuracy of the base model up to 20% on the AIME25 and a 12% increase on a French MATH level 5 benchmark. These results challenge the prevailing assumption that massive datasets are aprerequisite for strong reasoning performance in LLMs, highlighting the potential of strategic data curation and optimized fine-tuning for enhancing both specialized skills and multilingual capabilities. Our findings have implications for the efficient development of high-performing, multilingual LLMs, especially in resource-constrained scenarios.

Integration of cognitive tasks into artificial general intelligence test for large models

During the evolution of large models, performance evaluation is necessarily performed to assess their capabilities and ensure safety before practical application. However, current model evaluations mainly rely on specific tasks and datasets, lacking a united framework for assessing the multidimensional intelligence of large models. In this perspective, we advocate for a comprehensive framework of cognitive science-inspired artificial general intelligence (AGI) tests, aimed at fulfilling the testing needs of large models with enhanced capabilities. The cognitive science-inspired AGI tests encompass the full spectrum of intelligence facets, including crystallized intelligence, fluid intelligence, social intelligence, and embodied intelligence. To assess the multidimensional intelligence of large models, the AGI tests consist of a battery of well-designed cognitive tests adopted from human intelligence tests, and then naturally encapsulates into an immersive virtual community. We propose increasing the complexity of AGI testing tasks commensurate with advancements in large models and emphasizing the necessity for the interpretation of test results to avoid false negatives and false positives. We believe that cognitive science-inspired AGI tests will effectively guide the targeted improvement of large models in specific dimensions of intelligence and accelerate the integration of large models into human society.

Model Editing with Canonical Examples

We introduce model editing with canonical examples, a setting in which (1) a single learning example is provided per desired behavior, (2) evaluation is performed exclusively out-of-distribution, and (3) deviation from an initial model is strictly limited. A canonical example is a simple instance of good behavior, e.g., The capital of Mauritius is Port Louis) or bad behavior, e.g., An aspect of researchers is coldhearted). The evaluation set contains more complex examples of each behavior (like a paragraph in which the capital of Mauritius is called for.) We create three datasets and modify three more for model editing with canonical examples, covering knowledge-intensive improvements, social bias mitigation, and syntactic edge cases. In our experiments on Pythia language models, we find that LoRA outperforms full finetuning and MEMIT. We then turn to the Backpack language model architecture because it is intended to enable targeted improvement. The Backpack defines a large bank of sense vectors--a decomposition of the different uses of each word--which are weighted and summed to form the output logits of the model. We propose sense finetuning, which selects and finetunes a few (approx 10) sense vectors for each canonical example, and find that it outperforms other finetuning methods, e.g., 4.8% improvement vs 0.3%. Finally, we improve GPT-J-6B by an inference-time ensemble with just the changes from sense finetuning of a 35x smaller Backpack, in one setting outperforming editing GPT-J itself (4.1% vs 1.0%).

CliniQ: A Multi-faceted Benchmark for Electronic Health Record Retrieval with Semantic Match Assessment

Electronic Health Record (EHR) retrieval plays a pivotal role in various clinical tasks, but its development has been severely impeded by the lack of publicly available benchmarks. In this paper, we introduce a novel public EHR retrieval benchmark, CliniQ, to address this gap. We consider two retrieval settings: Single-Patient Retrieval and Multi-Patient Retrieval, reflecting various real-world scenarios. Single-Patient Retrieval focuses on finding relevant parts within a patient note, while Multi-Patient Retrieval involves retrieving EHRs from multiple patients. We build our benchmark upon 1,000 discharge summary notes along with the ICD codes and prescription labels from MIMIC-III, and collect 1,246 unique queries with 77,206 relevance judgments by further leveraging powerful LLMs as annotators. Additionally, we include a novel assessment of the semantic gap issue in EHR retrieval by categorizing matching types into string match and four types of semantic matches. On our proposed benchmark, we conduct a comprehensive evaluation of various retrieval methods, ranging from conventional exact match to popular dense retrievers. Our experiments find that BM25 sets a strong baseline and performs competitively to the dense retrievers, and general domain dense retrievers surprisingly outperform those designed for the medical domain. In-depth analyses on various matching types reveal the strengths and drawbacks of different methods, enlightening the potential for targeted improvement. We believe that our benchmark will stimulate the research communities to advance EHR retrieval systems.

UniversalNER: Targeted Distillation from Large Language Models for Open Named Entity Recognition

Large language models (LLMs) have demonstrated remarkable generalizability, such as understanding arbitrary entities and relations. Instruction tuning has proven effective for distilling LLMs into more cost-efficient models such as Alpaca and Vicuna. Yet such student models still trail the original LLMs by large margins in downstream applications. In this paper, we explore targeted distillation with mission-focused instruction tuning to train student models that can excel in a broad application class such as open information extraction. Using named entity recognition (NER) for case study, we show how ChatGPT can be distilled into much smaller UniversalNER models for open NER. For evaluation, we assemble the largest NER benchmark to date, comprising 43 datasets across 9 diverse domains such as biomedicine, programming, social media, law, finance. Without using any direct supervision, UniversalNER attains remarkable NER accuracy across tens of thousands of entity types, outperforming general instruction-tuned models such as Alpaca and Vicuna by over 30 absolute F1 points in average. With a tiny fraction of parameters, UniversalNER not only acquires ChatGPT's capability in recognizing arbitrary entity types, but also outperforms its NER accuracy by 7-9 absolute F1 points in average. Remarkably, UniversalNER even outperforms by a large margin state-of-the-art multi-task instruction-tuned systems such as InstructUIE, which uses supervised NER examples. We also conduct thorough ablation studies to assess the impact of various components in our distillation approach. We will release the distillation recipe, data, and UniversalNER models to facilitate future research on targeted distillation.

TAROT: Targeted Data Selection via Optimal Transport

We propose TAROT, a targeted data selection framework grounded in optimal transport theory. Previous targeted data selection methods primarily rely on influence-based greedy heuristics to enhance domain-specific performance. While effective on limited, unimodal data (i.e., data following a single pattern), these methods struggle as target data complexity increases. Specifically, in multimodal distributions, these heuristics fail to account for multiple inherent patterns, leading to suboptimal data selection. This work identifies two primary factors contributing to this limitation: (i) the disproportionate impact of dominant feature components in high-dimensional influence estimation, and (ii) the restrictive linear additive assumptions inherent in greedy selection strategies. To address these challenges, TAROT incorporates whitened feature distance to mitigate dominant feature bias, providing a more reliable measure of data influence. Building on this, TAROT uses whitened feature distance to quantify and minimize the optimal transport distance between the selected data and target domains. Notably, this minimization also facilitates the estimation of optimal selection ratios. We evaluate TAROT across multiple tasks, including semantic segmentation, motion prediction, and instruction tuning. Results consistently show that TAROT outperforms state-of-the-art methods, highlighting its versatility across various deep learning tasks. Code is available at https://github.com/vita-epfl/TAROT.

AnyAttack: Targeted Adversarial Attacks on Vision-Language Models toward Any Images

Due to their multimodal capabilities, Vision-Language Models (VLMs) have found numerous impactful applications in real-world scenarios. However, recent studies have revealed that VLMs are vulnerable to image-based adversarial attacks, particularly targeted adversarial images that manipulate the model to generate harmful content specified by the adversary. Current attack methods rely on predefined target labels to create targeted adversarial attacks, which limits their scalability and applicability for large-scale robustness evaluations. In this paper, we propose AnyAttack, a self-supervised framework that generates targeted adversarial images for VLMs without label supervision, allowing any image to serve as a target for the attack. Our framework employs the pre-training and fine-tuning paradigm, with the adversarial noise generator pre-trained on the large-scale LAION-400M dataset. This large-scale pre-training endows our method with powerful transferability across a wide range of VLMs. Extensive experiments on five mainstream open-source VLMs (CLIP, BLIP, BLIP2, InstructBLIP, and MiniGPT-4) across three multimodal tasks (image-text retrieval, multimodal classification, and image captioning) demonstrate the effectiveness of our attack. Additionally, we successfully transfer AnyAttack to multiple commercial VLMs, including Google Gemini, Claude Sonnet, Microsoft Copilot and OpenAI GPT. These results reveal an unprecedented risk to VLMs, highlighting the need for effective countermeasures.

TarGEN: Targeted Data Generation with Large Language Models

The rapid advancement of large language models (LLMs) has sparked interest in data synthesis techniques, aiming to generate diverse and high-quality synthetic datasets. However, these synthetic datasets often suffer from a lack of diversity and added noise. In this paper, we present TarGEN, a multi-step prompting strategy for generating high-quality synthetic datasets utilizing a LLM. An advantage of TarGEN is its seedless nature; it does not require specific task instances, broadening its applicability beyond task replication. We augment TarGEN with a method known as self-correction empowering LLMs to rectify inaccurately labeled instances during dataset creation, ensuring reliable labels. To assess our technique's effectiveness, we emulate 8 tasks from the SuperGLUE benchmark and finetune various language models, including encoder-only, encoder-decoder, and decoder-only models on both synthetic and original training sets. Evaluation on the original test set reveals that models trained on datasets generated by TarGEN perform approximately 1-2% points better than those trained on original datasets (82.84% via syn. vs. 81.12% on og. using Flan-T5). When incorporating instruction tuning, the performance increases to 84.54% on synthetic data vs. 81.49% on original data by Flan-T5. A comprehensive analysis of the synthetic dataset compared to the original dataset reveals that the synthetic dataset demonstrates similar or higher levels of dataset complexity and diversity. Furthermore, the synthetic dataset displays a bias level that aligns closely with the original dataset. Finally, when pre-finetuned on our synthetic SuperGLUE dataset, T5-3B yields impressive results on the OpenLLM leaderboard, surpassing the model trained on the Self-Instruct dataset by 4.14% points. We hope that TarGEN can be helpful for quality data generation and reducing the human efforts to create complex benchmarks.

Ethicist: Targeted Training Data Extraction Through Loss Smoothed Soft Prompting and Calibrated Confidence Estimation

Large pre-trained language models achieve impressive results across many tasks. However, recent works point out that pre-trained language models may memorize a considerable fraction of their training data, leading to the privacy risk of information leakage. In this paper, we propose a method named Ethicist for targeted training data extraction through loss smoothed soft prompting and calibrated confidence estimation, investigating how to recover the suffix in the training data when given a prefix. To elicit memorization in the attacked model, we tune soft prompt embeddings while keeping the model fixed. We further propose a smoothing loss that smooths the loss distribution of the suffix tokens to make it easier to sample the correct suffix. In order to select the most probable suffix from a collection of sampled suffixes and estimate the prediction confidence, we propose a calibrated confidence estimation method, which normalizes the confidence of the generated suffixes with a local estimation. We show that Ethicist significantly improves the extraction performance on a recently proposed public benchmark. We also investigate several factors influencing the data extraction performance, including decoding strategy, model scale, prefix length, and suffix length. Our code is available at https://github.com/thu-coai/Targeted-Data-Extraction.

Exploiting Pretrained Biochemical Language Models for Targeted Drug Design

Motivation: The development of novel compounds targeting proteins of interest is one of the most important tasks in the pharmaceutical industry. Deep generative models have been applied to targeted molecular design and have shown promising results. Recently, target-specific molecule generation has been viewed as a translation between the protein language and the chemical language. However, such a model is limited by the availability of interacting protein-ligand pairs. On the other hand, large amounts of unlabeled protein sequences and chemical compounds are available and have been used to train language models that learn useful representations. In this study, we propose exploiting pretrained biochemical language models to initialize (i.e. warm start) targeted molecule generation models. We investigate two warm start strategies: (i) a one-stage strategy where the initialized model is trained on targeted molecule generation (ii) a two-stage strategy containing a pre-finetuning on molecular generation followed by target specific training. We also compare two decoding strategies to generate compounds: beam search and sampling. Results: The results show that the warm-started models perform better than a baseline model trained from scratch. The two proposed warm-start strategies achieve similar results to each other with respect to widely used metrics from benchmarks. However, docking evaluation of the generated compounds for a number of novel proteins suggests that the one-stage strategy generalizes better than the two-stage strategy. Additionally, we observe that beam search outperforms sampling in both docking evaluation and benchmark metrics for assessing compound quality. Availability and implementation: The source code is available at https://github.com/boun-tabi/biochemical-lms-for-drug-design and the materials are archived in Zenodo at https://doi.org/10.5281/zenodo.6832145

SALOVA: Segment-Augmented Long Video Assistant for Targeted Retrieval and Routing in Long-Form Video Analysis

Despite advances in Large Multi-modal Models, applying them to long and untrimmed video content remains challenging due to limitations in context length and substantial memory overhead. These constraints often lead to significant information loss and reduced relevance in the model responses. With the exponential growth of video data across web platforms, understanding long-form video is crucial for advancing generalized intelligence. In this paper, we introduce SALOVA: Segment-Augmented LOng Video Assistant, a novel video-LLM framework designed to enhance the comprehension of lengthy video content through targeted retrieval process. We address two main challenges to achieve it: (i) We present the SceneWalk dataset, a high-quality collection of 87.8K long videos, each densely captioned at the segment level to enable models to capture scene continuity and maintain rich descriptive context. (ii) We develop robust architectural designs integrating dynamic routing mechanism and spatio-temporal projector to efficiently retrieve and process relevant video segments based on user queries. Our framework mitigates the limitations of current video-LMMs by allowing for precise identification and retrieval of relevant video segments in response to queries, thereby improving the contextual relevance of the generated responses. Through extensive experiments, SALOVA demonstrates enhanced capability in processing complex long-form videos, showing significant capability to maintain contextual integrity across extended sequences.

CoLoR-Filter: Conditional Loss Reduction Filtering for Targeted Language Model Pre-training

Selecting high-quality data for pre-training is crucial in shaping the downstream task performance of language models. A major challenge lies in identifying this optimal subset, a problem generally considered intractable, thus necessitating scalable and effective heuristics. In this work, we propose a data selection method, CoLoR-Filter (Conditional Loss Reduction Filtering), which leverages an empirical Bayes-inspired approach to derive a simple and computationally efficient selection criterion based on the relative loss values of two auxiliary models. In addition to the modeling rationale, we evaluate CoLoR-Filter empirically on two language modeling tasks: (1) selecting data from C4 for domain adaptation to evaluation on Books and (2) selecting data from C4 for a suite of downstream multiple-choice question answering tasks. We demonstrate favorable scaling both as we subselect more aggressively and using small auxiliary models to select data for large target models. As one headline result, CoLoR-Filter data selected using a pair of 150m parameter auxiliary models can train a 1.2b parameter target model to match a 1.2b parameter model trained on 25b randomly selected tokens with 25x less data for Books and 11x less data for the downstream tasks. Code: https://github.com/davidbrandfonbrener/color-filter-olmo Filtered data: https://huggingface.co/datasets/davidbrandfonbrener/color-filtered-c4

LESS: Selecting Influential Data for Targeted Instruction Tuning

Instruction tuning has unlocked powerful capabilities in large language models (LLMs), effectively using combined datasets to develop generalpurpose chatbots. However, real-world applications often require a specialized suite of skills (e.g., reasoning). The challenge lies in identifying the most relevant data from these extensive datasets to effectively develop specific capabilities, a setting we frame as targeted instruction tuning. We propose LESS, an optimizer-aware and practically efficient algorithm to effectively estimate data influences and perform Low-rank gradiEnt Similarity Search for instruction data selection. Crucially, LESS adapts existing influence formulations to work with the Adam optimizer and variable-length instruction data. LESS first constructs a highly reusable and transferable gradient datastore with low-dimensional gradient features and then selects examples based on their similarity to few-shot examples embodying a specific capability. Experiments show that training on a LESS-selected 5% of the data can often outperform training on the full dataset across diverse downstream tasks. Furthermore, the selected data is highly transferable: smaller models can be leveraged to select useful data for larger models and models from different families. Our qualitative analysis shows that our method goes beyond surface form cues to identify data that exemplifies the necessary reasoning skills for the intended downstream application.

Removing Neural Signal Artifacts with Autoencoder-Targeted Adversarial Transformers (AT-AT)

Electromyogenic (EMG) noise is a major contamination source in EEG data that can impede accurate analysis of brain-specific neural activity. Recent literature on EMG artifact removal has moved beyond traditional linear algorithms in favor of machine learning-based systems. However, existing deep learning-based filtration methods often have large compute footprints and prohibitively long training times. In this study, we present a new machine learning-based system for filtering EMG interference from EEG data using an autoencoder-targeted adversarial transformer (AT-AT). By leveraging the lightweight expressivity of an autoencoder to determine optimal time-series transformer application sites, our AT-AT architecture achieves a >90% model size reduction compared to published artifact removal models. The addition of adversarial training ensures that filtered signals adhere to the fundamental characteristics of EEG data. We trained AT-AT using published neural data from 67 subjects and found that the system was able to achieve comparable test performance to larger models; AT-AT posted a mean reconstructive correlation coefficient above 0.95 at an initial signal-to-noise ratio (SNR) of 2 dB and 0.70 at -7 dB SNR. Further research generalizing these results to broader sample sizes beyond these isolated test cases will be crucial; while outside the scope of this study, we also include results from a real-world deployment of AT-AT in the Appendix.

RAT: Adversarial Attacks on Deep Reinforcement Agents for Targeted Behaviors

Evaluating deep reinforcement learning (DRL) agents against targeted behavior attacks is critical for assessing their robustness. These attacks aim to manipulate the victim into specific behaviors that align with the attacker's objectives, often bypassing traditional reward-based defenses. Prior methods have primarily focused on reducing cumulative rewards; however, rewards are typically too generic to capture complex safety requirements effectively. As a result, focusing solely on reward reduction can lead to suboptimal attack strategies, particularly in safety-critical scenarios where more precise behavior manipulation is needed. To address these challenges, we propose RAT, a method designed for universal, targeted behavior attacks. RAT trains an intention policy that is explicitly aligned with human preferences, serving as a precise behavioral target for the adversary. Concurrently, an adversary manipulates the victim's policy to follow this target behavior. To enhance the effectiveness of these attacks, RAT dynamically adjusts the state occupancy measure within the replay buffer, allowing for more controlled and effective behavior manipulation. Our empirical results on robotic simulation tasks demonstrate that RAT outperforms existing adversarial attack algorithms in inducing specific behaviors. Additionally, RAT shows promise in improving agent robustness, leading to more resilient policies. We further validate RAT by guiding Decision Transformer agents to adopt behaviors aligned with human preferences in various MuJoCo tasks, demonstrating its effectiveness across diverse tasks.

Data Taggants: Dataset Ownership Verification via Harmless Targeted Data Poisoning

Dataset ownership verification, the process of determining if a dataset is used in a model's training data, is necessary for detecting unauthorized data usage and data contamination. Existing approaches, such as backdoor watermarking, rely on inducing a detectable behavior into the trained model on a part of the data distribution. However, these approaches have limitations, as they can be harmful to the model's performances or require unpractical access to the model's internals. Most importantly, previous approaches lack guarantee against false positives. This paper introduces data taggants, a novel non-backdoor dataset ownership verification technique. Our method uses pairs of out-of-distribution samples and random labels as secret keys, and leverages clean-label targeted data poisoning to subtly alter a dataset, so that models trained on it respond to the key samples with the corresponding key labels. The keys are built as to allow for statistical certificates with black-box access only to the model. We validate our approach through comprehensive and realistic experiments on ImageNet1k using ViT and ResNet models with state-of-the-art training recipes. Our findings demonstrate that data taggants can reliably make models trained on the protected dataset detectable with high confidence, without compromising validation accuracy, and demonstrates superiority over backdoor watermarking. Moreover, our method shows to be stealthy and robust against various defense mechanisms.

Prototype-supervised Adversarial Network for Targeted Attack of Deep Hashing

Due to its powerful capability of representation learning and high-efficiency computation, deep hashing has made significant progress in large-scale image retrieval. However, deep hashing networks are vulnerable to adversarial examples, which is a practical secure problem but seldom studied in hashing-based retrieval field. In this paper, we propose a novel prototype-supervised adversarial network (ProS-GAN), which formulates a flexible generative architecture for efficient and effective targeted hashing attack. To the best of our knowledge, this is the first generation-based method to attack deep hashing networks. Generally, our proposed framework consists of three parts, i.e., a PrototypeNet, a generator, and a discriminator. Specifically, the designed PrototypeNet embeds the target label into the semantic representation and learns the prototype code as the category-level representative of the target label. Moreover, the semantic representation and the original image are jointly fed into the generator for a flexible targeted attack. Particularly, the prototype code is adopted to supervise the generator to construct the targeted adversarial example by minimizing the Hamming distance between the hash code of the adversarial example and the prototype code. Furthermore, the generator is against the discriminator to simultaneously encourage the adversarial examples visually realistic and the semantic representation informative. Extensive experiments verify that the proposed framework can efficiently produce adversarial examples with better targeted attack performance and transferability over state-of-the-art targeted attack methods of deep hashing. The related codes could be available at https://github.com/xunguangwang/ProS-GAN .

One Surrogate to Fool Them All: Universal, Transferable, and Targeted Adversarial Attacks with CLIP

Deep Neural Networks (DNNs) have achieved widespread success yet remain prone to adversarial attacks. Typically, such attacks either involve frequent queries to the target model or rely on surrogate models closely mirroring the target model -- often trained with subsets of the target model's training data -- to achieve high attack success rates through transferability. However, in realistic scenarios where training data is inaccessible and excessive queries can raise alarms, crafting adversarial examples becomes more challenging. In this paper, we present UnivIntruder, a novel attack framework that relies solely on a single, publicly available CLIP model and publicly available datasets. By using textual concepts, UnivIntruder generates universal, transferable, and targeted adversarial perturbations that mislead DNNs into misclassifying inputs into adversary-specified classes defined by textual concepts. Our extensive experiments show that our approach achieves an Attack Success Rate (ASR) of up to 85% on ImageNet and over 99% on CIFAR-10, significantly outperforming existing transfer-based methods. Additionally, we reveal real-world vulnerabilities, showing that even without querying target models, UnivIntruder compromises image search engines like Google and Baidu with ASR rates up to 84%, and vision language models like GPT-4 and Claude-3.5 with ASR rates up to 80%. These findings underscore the practicality of our attack in scenarios where traditional avenues are blocked, highlighting the need to reevaluate security paradigms in AI applications.

A Course Correction in Steerability Evaluation: Revealing Miscalibration and Side Effects in LLMs

Despite advances in large language models (LLMs) on reasoning and instruction-following benchmarks, it remains unclear whether they can reliably produce outputs aligned with a broad variety of user goals, a concept we refer to as steerability. The abundance of methods proposed to modify LLM behavior makes it unclear whether current LLMs are already steerable, or require further intervention. In particular, LLMs may exhibit (i) poor coverage, where rare user goals are underrepresented; (ii) miscalibration, where models overshoot requests; and (iii) side effects, where changes to one dimension of text inadvertently affect others. To systematically evaluate these failures, we introduce a framework based on a multi-dimensional goal space that models user goals and LLM outputs as vectors with dimensions corresponding to text attributes (e.g., reading difficulty). Applied to a text-rewriting task, we find that current LLMs struggle with steerability, as side effects are persistent. Interventions to improve steerability, such as prompt engineering, best-of-N sampling, and reinforcement learning fine-tuning, have varying effectiveness, yet side effects remain problematic. Our findings suggest that even strong LLMs struggle with steerability, and existing alignment strategies may be insufficient. We open-source our steerability evaluation framework at https://github.com/MLD3/steerability.

Unpacking DPO and PPO: Disentangling Best Practices for Learning from Preference Feedback

Learning from preference feedback has emerged as an essential step for improving the generation quality and performance of modern language models (LMs). Despite its widespread use, the way preference-based learning is applied varies wildly, with differing data, learning algorithms, and evaluations used, making disentangling the impact of each aspect difficult. In this work, we identify four core aspects of preference-based learning: preference data, learning algorithm, reward model, and policy training prompts, systematically investigate the impact of these components on downstream model performance, and suggest a recipe for strong learning for preference feedback. Our findings indicate that all aspects are important for performance, with better preference data leading to the largest improvements, followed by the choice of learning algorithm, the use of improved reward models, and finally the use of additional unlabeled prompts for policy training. Notably, PPO outperforms DPO by up to 2.5% in math and 1.2% in general domains. High-quality preference data leads to improvements of up to 8% in instruction following and truthfulness. Despite significant gains of up to 5% in mathematical evaluation when scaling up reward models, we surprisingly observe marginal improvements in other categories. We publicly release the code used for training (https://github.com/hamishivi/EasyLM) and evaluating (https://github.com/allenai/open-instruct) our models, along with the models and datasets themselves (https://huggingface.co/collections/allenai/tulu-v25-suite-66676520fd578080e126f618).

GREATERPROMPT: A Unified, Customizable, and High-Performing Open-Source Toolkit for Prompt Optimization

LLMs have gained immense popularity among researchers and the general public for its impressive capabilities on a variety of tasks. Notably, the efficacy of LLMs remains significantly dependent on the quality and structure of the input prompts, making prompt design a critical factor for their performance. Recent advancements in automated prompt optimization have introduced diverse techniques that automatically enhance prompts to better align model outputs with user expectations. However, these methods often suffer from the lack of standardization and compatibility across different techniques, limited flexibility in customization, inconsistent performance across model scales, and they often exclusively rely on expensive proprietary LLM APIs. To fill in this gap, we introduce GREATERPROMPT, a novel framework that democratizes prompt optimization by unifying diverse methods under a unified, customizable API while delivering highly effective prompts for different tasks. Our framework flexibly accommodates various model scales by leveraging both text feedback-based optimization for larger LLMs and internal gradient-based optimization for smaller models to achieve powerful and precise prompt improvements. Moreover, we provide a user-friendly Web UI that ensures accessibility for non-expert users, enabling broader adoption and enhanced performance across various user groups and application scenarios. GREATERPROMPT is available at https://github.com/psunlpgroup/GreaterPrompt via GitHub, PyPI, and web user interfaces.

MedAgentBench: A Realistic Virtual EHR Environment to Benchmark Medical LLM Agents

Recent large language models (LLMs) have demonstrated significant advancements, particularly in their ability to serve as agents thereby surpassing their traditional role as chatbots. These agents can leverage their planning and tool utilization capabilities to address tasks specified at a high level. However, a standardized dataset to benchmark the agent capabilities of LLMs in medical applications is currently lacking, making the evaluation of LLMs on complex tasks in interactive healthcare environments challenging. To address this gap, we introduce MedAgentBench, a broad evaluation suite designed to assess the agent capabilities of large language models within medical records contexts. MedAgentBench encompasses 300 patient-specific clinically-derived tasks from 10 categories written by human physicians, realistic profiles of 100 patients with over 700,000 data elements, a FHIR-compliant interactive environment, and an accompanying codebase. The environment uses the standard APIs and communication infrastructure used in modern EMR systems, so it can be easily migrated into live EMR systems. MedAgentBench presents an unsaturated agent-oriented benchmark that current state-of-the-art LLMs exhibit some ability to succeed at. The best model (Claude 3.5 Sonnet v2) achieves a success rate of 69.67%. However, there is still substantial space for improvement which gives the community a next direction to optimize. Furthermore, there is significant variation in performance across task categories. MedAgentBench establishes this and is publicly available at https://github.com/stanfordmlgroup/MedAgentBench , offering a valuable framework for model developers to track progress and drive continuous improvements in the agent capabilities of large language models within the medical domain.

Enhancing End Stage Renal Disease Outcome Prediction: A Multi-Sourced Data-Driven Approach

Objective: To improve prediction of Chronic Kidney Disease (CKD) progression to End Stage Renal Disease (ESRD) using machine learning (ML) and deep learning (DL) models applied to an integrated clinical and claims dataset of varying observation windows, supported by explainable AI (XAI) to enhance interpretability and reduce bias. Materials and Methods: We utilized data about 10,326 CKD patients, combining their clinical and claims information from 2009 to 2018. Following data preprocessing, cohort identification, and feature engineering, we evaluated multiple statistical, ML and DL models using data extracted from five distinct observation windows. Feature importance and Shapley value analysis were employed to understand key predictors. Models were tested for robustness, clinical relevance, misclassification errors and bias issues. Results: Integrated data models outperformed those using single data sources, with the Long Short-Term Memory (LSTM) model achieving the highest AUC (0.93) and F1 score (0.65). A 24-month observation window was identified as optimal for balancing early detection and prediction accuracy. The 2021 eGFR equation improved prediction accuracy and reduced racial bias, notably for African American patients. Discussion: Improved ESRD prediction accuracy, results interpretability and bias mitigation strategies presented in this study have the potential to significantly enhance CKD and ESRD management, support targeted early interventions and reduce healthcare disparities. Conclusion: This study presents a robust framework for predicting ESRD outcomes in CKD patients, improving clinical decision-making and patient care through multi-sourced, integrated data and AI/ML methods. Future research will expand data integration and explore the application of this framework to other chronic diseases.

Iterative Service-Learning: A Computing-Based Case-study Applied to Small Rural Organizations

This paper describes the iterative use of service learning to develop, review, and improve computing-based artifacts. It is well-known that computing students benefit from service-learning experiences as do the community partners. It is also well-known that computing artifacts rarely function well long-term without versioning and updates. Service-learning projects are often one-time engagements, completed by single teams of students over the course of a semester course. This limits the benefit for community partners that do not have the expertise or resources to review and update a project on their own. Over several years, teams of undergraduate students in a capstone course created tailored social media plans for numerous small rural organizations. The projects were required to meet client specific needs, with identified audiences, measurable goals, and strategies and tactics to reach the identified goals. This paper builds on previously results for 60 projects conducted over several years. Nine clients were selected to participate in the iterative follow-up process, where new student teams conducted client interviews, reviewed the initial plans, and analyzed metrics from the current strategies and tactics to provide updated, improved artifacts. Using ABET learning objectives as a basis, clients reviewed the student teams and artifacts. This longitudinal study discusses the impact of this intervention to increase implementation and sustained use rates of computing artifacts developed through service learning. Both students and clients reported high satisfaction levels, and clients were particularly satisfied with the iterative improvement process. This research demonstrates an innovative practice for creating and maintaining computing artifacts through iterative service learning, while addressing the resource constraints of small organizations.

LLMRec: Large Language Models with Graph Augmentation for Recommendation

The problem of data sparsity has long been a challenge in recommendation systems, and previous studies have attempted to address this issue by incorporating side information. However, this approach often introduces side effects such as noise, availability issues, and low data quality, which in turn hinder the accurate modeling of user preferences and adversely impact recommendation performance. In light of the recent advancements in large language models (LLMs), which possess extensive knowledge bases and strong reasoning capabilities, we propose a novel framework called LLMRec that enhances recommender systems by employing three simple yet effective LLM-based graph augmentation strategies. Our approach leverages the rich content available within online platforms (e.g., Netflix, MovieLens) to augment the interaction graph in three ways: (i) reinforcing user-item interaction egde, (ii) enhancing the understanding of item node attributes, and (iii) conducting user node profiling, intuitively from the natural language perspective. By employing these strategies, we address the challenges posed by sparse implicit feedback and low-quality side information in recommenders. Besides, to ensure the quality of the augmentation, we develop a denoised data robustification mechanism that includes techniques of noisy implicit feedback pruning and MAE-based feature enhancement that help refine the augmented data and improve its reliability. Furthermore, we provide theoretical analysis to support the effectiveness of LLMRec and clarify the benefits of our method in facilitating model optimization. Experimental results on benchmark datasets demonstrate the superiority of our LLM-based augmentation approach over state-of-the-art techniques. To ensure reproducibility, we have made our code and augmented data publicly available at: https://github.com/HKUDS/LLMRec.git

A Domain-Agnostic Approach for Characterization of Lifelong Learning Systems

Despite the advancement of machine learning techniques in recent years, state-of-the-art systems lack robustness to "real world" events, where the input distributions and tasks encountered by the deployed systems will not be limited to the original training context, and systems will instead need to adapt to novel distributions and tasks while deployed. This critical gap may be addressed through the development of "Lifelong Learning" systems that are capable of 1) Continuous Learning, 2) Transfer and Adaptation, and 3) Scalability. Unfortunately, efforts to improve these capabilities are typically treated as distinct areas of research that are assessed independently, without regard to the impact of each separate capability on other aspects of the system. We instead propose a holistic approach, using a suite of metrics and an evaluation framework to assess Lifelong Learning in a principled way that is agnostic to specific domains or system techniques. Through five case studies, we show that this suite of metrics can inform the development of varied and complex Lifelong Learning systems. We highlight how the proposed suite of metrics quantifies performance trade-offs present during Lifelong Learning system development - both the widely discussed Stability-Plasticity dilemma and the newly proposed relationship between Sample Efficient and Robust Learning. Further, we make recommendations for the formulation and use of metrics to guide the continuing development of Lifelong Learning systems and assess their progress in the future.

Health Text Simplification: An Annotated Corpus for Digestive Cancer Education and Novel Strategies for Reinforcement Learning

Objective: The reading level of health educational materials significantly influences the understandability and accessibility of the information, particularly for minoritized populations. Many patient educational resources surpass the reading level and complexity of widely accepted standards. There is a critical need for high-performing text simplification models in health information to enhance dissemination and literacy. This need is particularly acute in cancer education, where effective prevention and screening education can substantially reduce morbidity and mortality. Methods: We introduce Simplified Digestive Cancer (SimpleDC), a parallel corpus of cancer education materials tailored for health text simplification research, comprising educational content from the American Cancer Society, Centers for Disease Control and Prevention, and National Cancer Institute. Utilizing SimpleDC alongside the existing Med-EASi corpus, we explore Large Language Model (LLM)-based simplification methods, including fine-tuning, reinforcement learning (RL), reinforcement learning with human feedback (RLHF), domain adaptation, and prompt-based approaches. Our experimentation encompasses Llama 2 and GPT-4. A novel RLHF reward function is introduced, featuring a lightweight model adept at distinguishing between original and simplified texts, thereby enhancing the model's effectiveness with unlabeled data. Results: Fine-tuned Llama 2 models demonstrated high performance across various metrics. Our innovative RLHF reward function surpassed existing RL text simplification reward functions in effectiveness. The results underscore that RL/RLHF can augment fine-tuning, facilitating model training on unlabeled text and improving performance.

FineTuneBench: How well do commercial fine-tuning APIs infuse knowledge into LLMs?

There is great interest in fine-tuning frontier large language models (LLMs) to inject new information and update existing knowledge. While commercial LLM fine-tuning APIs from providers such as OpenAI and Google promise flexible adaptation for various applications, the efficacy of fine-tuning remains unclear. In this study, we introduce FineTuneBench, an evaluation framework and dataset for understanding how well commercial fine-tuning APIs can successfully learn new and updated knowledge. We analyze five frontier LLMs with commercially available fine-tuning APIs, including GPT-4o and Gemini 1.5 Pro, on their effectiveness in two settings: (1) ingesting novel information, such as recent news events and new people profiles, and (2) updating existing knowledge, such as updated medical guidelines and code frameworks. Our results reveal substantial shortcomings in all the models' abilities to effectively learn new information through fine-tuning, with an average generalization accuracy of 37% across all models. When updating existing knowledge, such as incorporating medical guideline updates, commercial fine-tuning APIs show even more limited capability (average generalization accuracy of 19%). Overall, fine-tuning GPT-4o mini is the most effective for infusing new knowledge and updating knowledge, followed by GPT-3.5 Turbo and GPT-4o. The fine-tuning APIs for Gemini 1.5 Flesh and Gemini 1.5 Pro are unable to learn new knowledge or update existing knowledge. These findings underscore a major shortcoming in using current commercial fine-tuning services to achieve reliable knowledge infusion in common scenarios. We open source the FineTuneBench dataset at https://github.com/kevinwu23/StanfordFineTuneBench.

Manipulating Large Language Models to Increase Product Visibility

Large language models (LLMs) are increasingly being integrated into search engines to provide natural language responses tailored to user queries. Customers and end-users are also becoming more dependent on these models for quick and easy purchase decisions. In this work, we investigate whether recommendations from LLMs can be manipulated to enhance a product's visibility. We demonstrate that adding a strategic text sequence (STS) -- a carefully crafted message -- to a product's information page can significantly increase its likelihood of being listed as the LLM's top recommendation. To understand the impact of STS, we use a catalog of fictitious coffee machines and analyze its effect on two target products: one that seldom appears in the LLM's recommendations and another that usually ranks second. We observe that the strategic text sequence significantly enhances the visibility of both products by increasing their chances of appearing as the top recommendation. This ability to manipulate LLM-generated search responses provides vendors with a considerable competitive advantage and has the potential to disrupt fair market competition. Just as search engine optimization (SEO) revolutionized how webpages are customized to rank higher in search engine results, influencing LLM recommendations could profoundly impact content optimization for AI-driven search services. Code for our experiments is available at https://github.com/aounon/llm-rank-optimizer.

A Toolbox for Surfacing Health Equity Harms and Biases in Large Language Models

Large language models (LLMs) hold immense promise to serve complex health information needs but also have the potential to introduce harm and exacerbate health disparities. Reliably evaluating equity-related model failures is a critical step toward developing systems that promote health equity. In this work, we present resources and methodologies for surfacing biases with potential to precipitate equity-related harms in long-form, LLM-generated answers to medical questions and then conduct an empirical case study with Med-PaLM 2, resulting in the largest human evaluation study in this area to date. Our contributions include a multifactorial framework for human assessment of LLM-generated answers for biases, and EquityMedQA, a collection of seven newly-released datasets comprising both manually-curated and LLM-generated questions enriched for adversarial queries. Both our human assessment framework and dataset design process are grounded in an iterative participatory approach and review of possible biases in Med-PaLM 2 answers to adversarial queries. Through our empirical study, we find that the use of a collection of datasets curated through a variety of methodologies, coupled with a thorough evaluation protocol that leverages multiple assessment rubric designs and diverse rater groups, surfaces biases that may be missed via narrower evaluation approaches. Our experience underscores the importance of using diverse assessment methodologies and involving raters of varying backgrounds and expertise. We emphasize that while our framework can identify specific forms of bias, it is not sufficient to holistically assess whether the deployment of an AI system promotes equitable health outcomes. We hope the broader community leverages and builds on these tools and methods towards realizing a shared goal of LLMs that promote accessible and equitable healthcare for all.

The ELEVATE-AI LLMs Framework: An Evaluation Framework for Use of Large Language Models in HEOR: an ISPOR Working Group Report

Introduction. Generative Artificial Intelligence, particularly large language models (LLMs), offers transformative potential for Health Economics and Outcomes Research (HEOR). However, evaluating the quality, transparency, and rigor of LLM-assisted research lacks standardized guidance. This article introduces the ELEVATE AI LLMs framework and checklist, designed to support researchers and reviewers in assessing LLM use in HEOR. Methods. The ELEVATE AI LLMs framework was developed through a targeted review of existing guidelines and evaluation frameworks. The framework comprises ten evaluation domains, including model characteristics, accuracy, comprehensiveness, and fairness. The accompanying checklist operationalizes the framework. To validate the framework, we applied it to two published studies, demonstrating its usability across different HEOR tasks. Results. The ELEVATE AI LLMs framework provides a comprehensive structure for evaluating LLM-assisted research, while the checklist facilitates practical application. Validation of the framework and checklist on studies of systematic literature reviews and health economic modeling highlighted their ability to identify strengths and gaps in reporting. Limitations. While the ELEVATE AI LLMs framework provides robust guidance, its broader generalizability and applicability to diverse HEOR tasks require further empirical testing. Additionally, several metrics adapted from computer science need further validation in HEOR contexts. Conclusion. The ELEVATE AI LLMs framework and checklist fill a critical gap in HEOR by offering structured guidance for evaluating LLM-assisted research. By promoting transparency, accuracy, and reproducibility, they aim to standardize and improve the integration of LLMs into HEOR, ensuring their outputs meet the field's rigorous standards.

Harnessing the Potential of Gen-AI Coding Assistants in Public Sector Software Development

The study on GitHub Copilot by GovTech Singapore's Engineering Productivity Programme (EPP) reveals significant potential for AI Code Assistant tools to boost developer productivity and improve application quality in the public sector. Highlighting the substantial benefits for the public sector, the study observed an increased productivity (coding / tasks speed increased by 21-28%), which translates into accelerated development, and quicker go-to-market, with a notable consensus (95%) that the tool increases developer satisfaction. Particularly, junior developers experienced considerable efficiency gains and reduced coding times, illustrating Copilot's capability to enhance job satisfaction by easing routine tasks. This advancement allows for a sharper focus on complex projects, faster learning, and improved code quality. Recognising the strategic importance of these tools, the study recommends the development of an AI Framework to maximise such benefits while cautioning against potential over-reliance without solid foundational programming skills. It also advises public sector developers to classify their code as "Open" to use Gen-AI Coding Assistant tools on the Cloud like GitHub Copilot and to consider self-hosted tools like Codeium or Code Llama for confidential code to leverage technology efficiently within the public sector framework. With up to 8,000 developers, comprising both public officers and vendors developing applications for the public sector and its customers, there is significant potential to enhance productivity.