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<!DOCTYPE html>
<html lang="en">
<head>
    <meta charset="UTF-8">
    <meta name="viewport" content="width=device-width, initial-scale=1.0">
    <title>Holistic Health Explorer | Advanced Database Integration</title>
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        .nav-link::after {
            content: '';
            position: absolute;
            bottom: 0;
            left: 0;
            width: 0;
            height: 2px;
            background-color: white;
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        .nav-link:hover::after {
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            transition: all 0.3s ease;
        }
        
        .search-focus:focus {
            transform: scale(1.02);
            box-shadow: 0 5px 15px rgba(43, 138, 62, 0.1);
        }
        
        .database-badge {
            display: inline-block;
            padding: 2px 8px;
            border-radius: 12px;
            font-size: 12px;
            font-weight: 500;
            background-color: #ebfbee;
            color: #2b8a3e;
        }
        
        .database-chip {
            display: inline-flex;
            align-items: center;
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            font-size: 11px;
            font-weight: 500;
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            border: 1px solid #dee2e6;
            margin-right: 6px;
            margin-bottom: 6px;
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            margin-right: 4px;
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        }
        
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            height: 300px;
            background-color: #f8f9fa;
            border-radius: 8px;
            position: relative;
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        .graph-node {
            position: absolute;
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            height: 80px;
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            transform: translateX(5px);
        }
        
        .database-relation {
            position: relative;
            padding-left: 20px;
        }
        
        .database-relation::before {
            content: '';
            position: absolute;
            left: 0;
            top: 8px;
            width: 12px;
            height: 12px;
            border-radius: 2px;
        }
        
        .ncbi-relation::before { background-color: #2b8a3e; }
        .pubchem-relation::before { background-color: #1971c2; }
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</head>
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                    <span class="text-lg font-medium">Health<span class="font-light">Explorer</span></span>
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    <!-- Hero Section -->
    <section class="health-gradient text-gray-800 pt-16 pb-12 relative overflow-hidden">
        <div class="container mx-auto px-6 relative z-10">
            <div class="flex flex-col lg:flex-row items-center">
                <div class="lg:w-2/3 mb-8 lg:mb-0">
                    <div class="flex flex-wrap items-center mb-3">
                        <span class="database-badge px-3 py-1 text-xs mr-3 mb-2">
                            <i class="fas fa-database mr-1"></i> 27 Integrated Health Databases
                        </span>
                        <span class="database-badge px-3 py-1 text-xs mr-3 mb-2">
                            <i class="fas fa-brain mr-1"></i> AI-Powered Cross-References
                        </span>
                    </div>
                    <h1 class="text-2xl md:text-3xl font-light leading-tight mb-3">
                        Advanced Health <span class="font-medium">Database Explorer</span><br>
                        <span class="typewriter inline-block text-xl" aria-live="polite">Cross-Referencing Scientific Research</span>
                    </h1>
                    <p class="text-gray-600 mb-6 max-w-lg text-sm">
                        Our intelligent system connects research across multiple databases to reveal hidden relationships between nutrition, 
                        microbiome science, herbal medicine, and clinical studies.
                    </p>
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    <script>
        // Extended sample data with cross-database relationships
        const sampleResults = [
            {
                id: 'res1',
                title: "Curcumin's Anti-Inflammatory Mechanisms",
                source: "PubMed Central",
                year: "2023",
                type: "Review Article",
                databases: ["PubMed", "PubChem", "Clinical Trials"],
                snippet: "Comprehensive review of curcumin's anti-inflammatory mechanisms through NF-κB pathway inhibition and clinical applications in chronic inflammatory conditions.",
                link: "https://www.ncbi.nlm.nih.gov/pmc/articles/example",
                relevance: 98,
                categories: ["herbal", "nutrition"],
                related: ["res2", "res3", "res5", "res8"],
                compounds: ["Curcumin", "Turmeric"],
                pathways: ["NF-κB", "COX-2"],
                genes: ["TNF", "IL6"]
            },
            {
                id: 'res2',
                title: "Microbiome Modulation by Curcumin",
                source: "Human Microbiome Project",
                year: "2022",
                type: "Research Study",
                databases: ["Microbiome", "NCBI", "PubMed"],
                snippet: "Study showing curcumin's impact on gut microbiota diversity and its correlation with reduced systemic inflammation markers in human subjects.",
                link: "https://hmpdacc.org/example",
                relevance: 95,
                categories: ["microbiome", "nutrition"],
                related: ["res1", "res4", "res6"],
                bacteria: ["Bacteroides", "Lactobacillus"],
                metabolites: ["Butyrate"]
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            {
                id: 'res3',
                title: "Curcumin Chemical Properties & Bioavailability",
                source: "PubChem",
                year: "2023",
                type: "Chemical Database",
                databases: ["PubChem", "FoodData"],
                snippet: "Detailed chemical properties, solubility, and known biological activities of curcumin (diferuloylmethane), including bioavailability enhancement methods.",
                link: "https://pubchem.ncbi.nlm.nih.gov/compound/curcumin",
                relevance: 92,
                categories: ["nutrition"],
                related: ["res1", "res7"],
                solubility: "Lipophilic",
                bioavailability: "Low (enhanced with piperine)"
            },
            {
                id: 'res4',
                title: "Traditional Uses of Turmeric",
                source: "Dr. Duke's Phytochemical",
                year: "2021",
                type: "Ethnobotanical Database",
                databases: ["Phytochemical", "PubMed"],
                snippet: "Documentation of turmeric's traditional uses in Ayurvedic medicine for inflammatory conditions, wound healing, and digestive disorders.",
                link: "https://phytochem.nal.usda.gov/example",
                relevance: 89,
                categories: ["herbal"],
                related: ["res1", "res5"],
                traditionalUses: ["Inflammation", "Digestion", "Wound Healing"]
            },
            {
                id: 'res5',
                title: "Curcumin Clinical Trials for IBD",
                source: "ClinicalTrials.gov",
                year: "2022",
                type: "Clinical Trial",
                databases: ["Clinical Trials", "PubMed"],
                snippet: "Randomized controlled trial examining curcumin's effects on inflammatory bowel disease symptoms and biomarkers.",
                link: "https://clinicaltrials.gov/example",
                relevance: 94,
                categories: ["clinical"],
                related: ["res1", "res2", "res8"],
                conditions: ["Crohn's Disease", "Ulcerative Colitis"],
                outcomes: ["Reduced CRP", "Improved symptoms"]
            },
            {
                id: 'res6',
                title: "Gut Microbiota and Inflammation Pathways",
                source: "NCBI Gene",
                year: "2023",
                type: "Genomic Study",
                databases: ["NCBI", "Microbiome"],
                snippet: "Analysis of how specific gut bacteria influence inflammatory pathways relevant to autoimmune conditions.",
                link: "https://www.ncbi.nlm.nih.gov/gene/example",
                relevance: 90,
                categories: ["microbiome"],
                related: ["res2", "res7"],
                genes: ["TLR4", "NOD2"],
                bacteria: ["E. coli", "B. fragilis"]
            },
            {
                id: 'res7',
                title: "Piperine Enhancement of Curcumin Bioavailability",
                source: "FoodData Central",
                year: "2021",
                type: "Nutrition Study",
                databases: ["FoodData", "PubChem"],
                snippet: "Study demonstrating how piperine from black pepper enhances curcumin bioavailability by 2000% through metabolic pathway modulation.",
                link: "https://fdc.nal.usda.gov/example",
                relevance: 93,
                categories: ["nutrition"],
                related: ["res1", "res3"],
                compounds: ["Piperine", "Curcumin"],
                mechanism: "Inhibition of glucuronidation"
            },
            {
                id: 'res8',
                title: "Comparative Analysis of Anti-Inflammatory Compounds",
                source: "PubMed",
                year: "2023",
                type: "Meta-Analysis",
                databases: ["PubMed", "PubChem", "Clinical Trials"],
                snippet: "Systematic comparison of curcumin, resveratrol, and other natural compounds' anti-inflammatory efficacy across clinical studies.",
                link: "https://pubmed.ncbi.nlm.nih.gov/example",
                relevance: 96,
                categories: ["clinical", "nutrition"],
                related: ["res1", "res5"],
                compounds: ["Curcumin", "Resveratrol", "Quercetin"],
                conclusion: "Curcumin shows strongest evidence for chronic inflammation"
            },
            {
                id: 'res9',
                title: "Curcumin Metabolites and Microbiome Interactions",
                source: "Microbiome Journal",
                year: "2023",
                type: "Research Paper",
                databases: ["Microbiome", "PubChem"],
                snippet: "Identification of specific curcumin metabolites produced by gut bacteria and their anti-inflammatory effects on intestinal epithelium.",
                link: "https://microbiomejournal.com/example",
                relevance: 91,
                categories: ["microbiome"],
                related: ["res1", "res2", "res6"],
                metabolites: ["Tetrahydrocurcumin", "Hexahydrocurcumin"],
                effects: ["Reduced IL-8", "Improved barrier function"]
            },
            {
                id: 'res10',
                title: "Traditional Preparation Methods for Turmeric",
                source: "Ethnobotanical Database",
                year: "2020",
                type: "Cultural Study",
                databases: ["Phytochemical", "FoodData"],
                snippet: "Analysis of traditional preparation methods that enhance turmeric's bioavailability and therapeutic effects in various cultural practices.",
                link: "https://ethnobotany.org/example",
                relevance: 87,
                categories: ["herbal"],
                related: ["res1", "res4", "res7"],
                methods: ["Heating with fats", "Combination with pepper"]
            }
        ];

        // AI Suggestions based on search patterns
        const aiSuggestions = [
            {
                title: "Explore Related Metabolic Pathways",
                description: "Curcumin interacts with multiple inflammatory pathways including NF-κB, COX-2, and LOX. View the complete pathway map.",
                icon: "fas fa-project-diagram",
                color: "text-blue-500",
                action: "View Pathways"
            },
            {
                title: "Compare with Similar Compounds",
                description: "Resveratrol and quercetin share some anti-inflammatory mechanisms with curcumin. See comparative effectiveness data.",
                icon: "fas fa-balance-scale",
                color: "text-purple-500",
                action: "Compare Compounds"
            },
            {
                title: "Microbiome Interaction Analysis",
                description: "View how curcumin metabolites produced by gut bacteria contribute to its systemic effects.",
                icon: "fas fa-bacterium",
                color: "text-green-500",
                action: "Analyze Interactions"
            },
            {
                title: "Bioavailability Enhancement Methods",
                description: "Discover formulations and combinations that significantly improve curcumin absorption.",
                icon: "fas fa-chart-line",
                color: "text-orange-500",
                action: "View Methods"
            }
        ];

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            // Search functionality
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                if (e.key === 'Enter') {
                    performSearch();
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            function performSearch() {
                const searchTerm = document.getElementById('healthSearchInput').value.trim();
                if (searchTerm) {
                    // Show loading state
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                    const originalButtonText = searchButton.innerHTML;
                    searchButton.innerHTML = '<i class="fas fa-spinner fa-spin mr-2"></i> Analyzing...';
                    searchButton.disabled = true;
                    
                    // In a real app, this would be API calls to the various databases
                    // For this demo, we'll use setTimeout to simulate network delay
                    setTimeout(() => {
                        // Display results
                        displayResults(searchTerm);
                        
                        // Restore button
                        searchButton.innerHTML = originalButtonText;
                        searchButton.disabled = false;
                    }, 1500);
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            }

            function displayResults(searchTerm) {
                const resultsContainer = document.getElementById('resultsContainer');
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                // Clear previous results
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                // Filter sample results (in real app, this would be done server-side)
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                            <div class="font-medium text-gray-800">${result.title}</div>
                            <div class="text-xs bg-green-100 text-green-800 px-2 py-1 rounded-full">${result.relevance}% relevance</div>
                        </div>
                        <div class="text-gray-500 text-xs mb-3">${result.source}${result.year} ${result.type}</div>
                        <div class="flex flex-wrap text-xs mb-3">
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                                `<span class="database-chip"><i class="fas fa-database"></i> ${db}</span>`
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                        </div>
                        <p class="text-gray-600 text-sm mb-4">${result.snippet}</p>
                        <div class="flex flex-wrap gap-2 mb-3">
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                                `<span class="text-xs px-2 py-1 rounded-full ${getCategoryColor(cat)}">${cat}</span>`
                            ).join('')}
                        </div>
                        <a href="${result.link}" target="_blank" class="text-green-600 text-sm font-medium inline-flex items-center">
                            View in ${result.databases[0]} <i class="fas fa-external-link-alt ml-1 text-xs"></i>
                        </a>
                    `;
                    resultsContainer.appendChild(resultElement);
                });
                
                // Display AI suggestions
                aiSuggestions.forEach(suggestion => {
                    const suggestionElement = document.createElement('div');
                    suggestionElement.className = 'suggestion-card bg-white p-4 rounded-lg shadow-sm border border-gray-100 mb-4';
                    suggestionElement.innerHTML = `
                        <div class="flex items-start mb-2">
                            <div class="${suggestion.color} text-lg mr-3 mt-1">
                                <i class="${suggestion.icon}"></i>
                            </div>
                            <div>
                                <h4 class="font-medium text-gray-800">${suggestion.title}</h4>
                                <p class="text-gray-600 text-sm">${suggestion.description}</p>
                            </div>
                        </div>
                        <button class="text-xs bg-gray-100 hover:bg-gray-200 text-gray-700 px-3 py-1 rounded-full mt-2 transition-colors">
                            ${suggestion.action} <i class="fas fa-arrow-right ml-1"></i>
                        </button>
                    `;
                    suggestionsContainer.appendChild(suggestionElement);
                });
                
                // Create knowledge graph
                createKnowledgeGraph(filteredResults);
                
                // Show results and suggestions sections
                searchResultsSection.classList.remove('hidden');
                aiSuggestionsSection.classList.remove('hidden');
                
                // Scroll to results
                searchResultsSection.scrollIntoView({ behavior: 'smooth' });
            }
            
            function getCategoryColor(category) {
                switch(category) {
                    case 'microbiome': return 'bg-purple-100 text-purple-800';
                    case 'nutrition': return 'bg-blue-100 text-blue-800';
                    case 'herbal': return 'bg-green-100 text-green-800';
                    case 'clinical': return 'bg-orange-100 text-orange-800';
                    default: return 'bg-gray-100 text-gray-800';
                }
            }
            
            function createKnowledgeGraph(results) {
                const graphContainer = document.getElementById('knowledgeGraph');
                graphContainer.innerHTML = '';
                
                // Create nodes for each result
                const nodes = [];
                const centerX = graphContainer.offsetWidth / 2;
                const centerY = graphContainer.offsetHeight / 2;
                const radius = Math.min(centerX, centerY) * 0.8;
                
                // Add main node (search term)
                const mainNode = document.createElement('div');
                mainNode.className = 'graph-node bg-green-500';
                mainNode.style.left = `${centerX - 40}px`;
                mainNode.style.top = `${centerY - 40}px`;
                mainNode.textContent = 'Curcumin';
                nodes.push({ element: mainNode, id: 'main', x: centerX, y: centerY });
                graphContainer.appendChild(mainNode);
                
                // Add result nodes in a circle around main node
                const angleStep = (2 * Math.PI) / results.length;
                results.forEach((result, index) => {
                    const angle = index * angleStep;
                    const x = centerX + radius * Math.cos(angle) - 40;
                    const y = centerY + radius * Math.sin(angle) - 40;
                    
                    const node = document.createElement('div');
                    node.className = 'graph-node bg-blue-500';
                    node.style.left = `${x}px`;
                    node.style.top = `${y}px`;
                    node.textContent = result.source.split(' ')[0];
                    
                    // Add relevance badge
                    const badge = document.createElement('div');
                    badge.className = 'relevance-badge';
                    badge.textContent = result.relevance.toString().charAt(0);
                    node.appendChild(badge);
                    
                    nodes.push({ element: node, id: result.id, x: x + 40, y: y + 40 });
                    graphContainer.appendChild(node);
                    
                    // Create line to main node
                    const line = document.createElement('div');
                    line.className = 'graph-line';
                    const length = Math.sqrt(Math.pow(x + 40 - centerX, 2) + Math.pow(y + 40 - centerY, 2));
                    const lineAngle = Math.atan2(y + 40 - centerY, x + 40 - centerX);
                    line.style.width = `${length}px`;
                    line.style.left = `${centerX}px`;
                    line.style.top = `${centerY}px`;
                    line.style.transform = `rotate(${lineAngle}rad)`;
                    graphContainer.appendChild(line);
                });
                
                // Add interactivity to nodes
                nodes.forEach(node => {
                    node.element.addEventListener('click', function() {
                        // Highlight this node and connected nodes
                        nodes.forEach(n => {
                            n.element.style.transform = '';
                            n.element.style.zIndex = '';
                        });
                        
                        this.style.transform = 'scale(1.2)';
                        this.style.zIndex = '10';
                        
                        // In a real app, this would show details for the selected node
                    });
                });
            }
            
            // Tab switching functionality
            const tabButtons = document.querySelectorAll('.tab-button');
            tabButtons.forEach(button => {
                button.addEventListener('click', function() {
                    // Remove active state from all buttons
                    tabButtons.forEach(btn => {
                        btn.classList.remove('border-b-2', 'border-green-500', 'text-green-600');
                        btn.classList.add('text-gray-500');
                    });
                    
                    // Add active state to clicked button
                    this.classList.add('border-b-2', 'border-green-500', 'text-green-600');
                    this.classList.remove('text-gray-500');
                    
                    // In a real app, this would filter the results by category
                });
            });
        });
    </script>
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