---
title: DNA CASINO
emoji: 🧬
colorFrom: green
colorTo: blue
sdk: gradio
sdk_version: 5.35.0
app_file: app.py
pinned: false
license: apache-2.0
short_description: DNA Diffusion
models: 
 - VIDraft/Gemma-3-R1984-27B
 - VIDraft/Gemma-3-R1984-12B
 - VIDraft/Gemma-3-R1984-4B
---
🎰 DNA CASINO: Hit the Genetic Jackpot! 🧬

🎲 When Biotech Meets Vegas = ??
Hey there! Today I'm thrilled to introduce something truly extraordinary. We've transformed DNA-Diffusion into a full-blown casino slot machine - welcome to DNA CASINO! 🎊

🎯 What's This All About?

🧬 Generate 200bp DNA Regulatory Sequences: AI-powered generation of cell-type specific synthetic biology sequences
🎰 Slot Machine UI: Watch each nucleotide (A,T,C,G) spin like real casino reels!
🔬 Real-time Protein Analysis: Instantly translate generated DNA to protein and get AI-powered structure/function analysis

💫 Key Features
1️⃣ Choose Your Cell Type (Like Casino Chips!)
🟢 K562 - Leukemia cell line
🔵 GM12878 - Lymphoblastoid cell line
🟡 HepG2 - Liver cancer cell line

2️⃣ Pull the Lever to Begin!
Just like a real slot machine - pull the lever or hit SPIN and watch 200 nucleotides whirl in spectacular fashion! 🎪

3️⃣ AI-Powered Protein Analysis

DNA → Protein translation
Structure/function prediction via vidraft/gemma-3-r1984-27b (ranked #2 in medical reliability on FACTS Grounding Leaderboard)
Cell-type specific insights

🛠️ Tech Stack
python🎨 Frontend: HTML/CSS/JS (Pure vanilla goodness!)
🧠 Backend: Gradio + DNA-Diffusion model
🤖 AI Analysis: vidraft/gemma-3-r1984-27b
⚡ GPU Acceleration: Hugging Face Spaces GPU

🎮 How to Play

Pick your cell-type chip 🎯
Pull the lever or hit SPIN! 🎰
Watch your DNA sequence generate ✨
Check out the protein analysis 🔬

🌟 What Makes It Special

Immersive casino theme: Neon lights, glowing effects, and that iconic 777 lever!
Scientific accuracy: Real codon tables, precise protein translation
Educational value: Learn DNA-protein relationships the fun way

🚀 Try It Now!
[VIDraft/DNA-CASINO](https://huggingface.co/spaces/VIDraft/DNA-CASINO)



Baed LLM Model: VIDraft/Gemma-3-R1984-27B
Powered by VIDraft

Based theory by 'pinello lab'

## Citation

If you use this application in your research, please cite:

```bibtex
@article{dnadiffusion2024,
  title={DNA-Diffusion: Leveraging Generative Models for Controlling Chromatin Accessibility and Gene Expression via Synthetic Regulatory Elements},
  author={DaSilva, Lucas Ferreira and Senan, Simon and Patel, Zain Munir and others},
  journal={bioRxiv},
  year={2024},
  doi={10.1101/2024.02.01.578352}
}
```

## Links

- [GitHub Repository](https://github.com/pinellolab/gradio-dna-diffusion)
- [DNA-Diffusion Paper](https://www.biorxiv.org/content/10.1101/2024.02.01.578352v1)
- [Pinello Lab](https://pinellolab.org)