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-OBJECTIVE: The objective of this study was to determine the risk of lifetime and current methamphetamine-induced psychosis in patients with methamphetamine dependence.	methamphetamine	psychosis	23433219	1
-In the presence of coronary artery stenosis, 3-min periods of intracoronary ISO infusion (10 ng/kg/min) increased heart rate and maximal rate of left ventricular pressure rise, which resulted in a decrease in percentage segmental shortening and ST-segment elevation of the epicardial electrocardiogram.	ISO	coronary artery stenosis	8819482	-1
-CONCLUSIONS: The combination of carboplatin and liposomal doxorubicin has modest activity in patients with recurrent cervical carcinoma.	doxorubicin	carcinoma	11745287	-1
-CONCLUSIONS: The combination of carboplatin and liposomal doxorubicin has modest activity in patients with recurrent cervical carcinoma.	carboplatin	carcinoma	11745287	-1
-Based upon these results, we conclude that amiodarone disrupts hepatic lipid homeostasis and that the increased expression of PPARalpha target genes is secondary to this toxic effect.	amiodarone	disrupts hepatic lipid homeostasis	15265979	1
-Based upon these results, we conclude that amiodarone disrupts hepatic lipid homeostasis and that the increased expression of PPARalpha target genes is secondary to this toxic effect.	PPARalpha	disrupts hepatic lipid homeostasis	15265979	-1
-In 5 consecutive patients with rheumatoid arthritis who received intravenous high-dose methylprednisolone (MP) therapy (1 g daily for 2 or 3 consecutive days), a decline in pulse rate was observed, most pronounced on day 4.	methylprednisolone	rheumatoid arthritis	3798047	-1
-In 5 consecutive patients with rheumatoid arthritis who received intravenous high-dose methylprednisolone (MP) therapy (1 g daily for 2 or 3 consecutive days), a decline in pulse rate was observed, most pronounced on day 4.	MP	rheumatoid arthritis	3798047	-1
-The present case suggests that obesity, hyperinsulinemia, insulin resistance, and long-term treatment with VPA may be all associated with the development of NAFLD; this side effect is reversible after VPA withdrawal.	VPA	obesity	19184102	1
-The present case suggests that obesity, hyperinsulinemia, insulin resistance, and long-term treatment with VPA may be all associated with the development of NAFLD; this side effect is reversible after VPA withdrawal.	VPA	NAFLD	19184102	1
-The present case suggests that obesity, hyperinsulinemia, insulin resistance, and long-term treatment with VPA may be all associated with the development of NAFLD; this side effect is reversible after VPA withdrawal.	VPA	obesity	19184102	1
-The present case suggests that obesity, hyperinsulinemia, insulin resistance, and long-term treatment with VPA may be all associated with the development of NAFLD; this side effect is reversible after VPA withdrawal.	VPA	hyperinsulinemia	19184102	1
-The present case suggests that obesity, hyperinsulinemia, insulin resistance, and long-term treatment with VPA may be all associated with the development of NAFLD; this side effect is reversible after VPA withdrawal.	VPA	NAFLD	19184102	1
-Regulation of signal transducer and activator of transcription 3 and apoptotic pathways by betaine attenuates isoproterenol-induced acute myocardial injury in rats.	isoproterenol	myocardial injury	25080425	-1
-Regulation of signal transducer and activator of transcription 3 and apoptotic pathways by betaine attenuates isoproterenol-induced acute myocardial injury in rats.	betaine	myocardial injury	25080425	-1
-These results provide important new mechanistic information regarding the hepatotoxic effects of amiodarone and indicate that PPARalpha protects against amiodarone-induced hepatotoxicity.	amiodarone	hepatotoxicity	15265979	1
-These results provide important new mechanistic information regarding the hepatotoxic effects of amiodarone and indicate that PPARalpha protects against amiodarone-induced hepatotoxicity.	PPARalpha	hepatotoxic	15265979	-1
-These results provide important new mechanistic information regarding the hepatotoxic effects of amiodarone and indicate that PPARalpha protects against amiodarone-induced hepatotoxicity.	PPARalpha	hepatotoxicity	15265979	-1
-CONCLUSION: Established visual field defects presumed to be due to Vigabatrin therapy did not usually progress in spite of continuing use of the medication.	Vigabatrin	visual field defects	15094729	-1
-These data give support to the hypothesis that the pathogenesis of Vigabatrin-associated visual field defects may be an idiosyncratic adverse drug reaction rather than dose-dependent toxicity.	Vigabatrin	visual field defects	15094729	-1
-These data give support to the hypothesis that the pathogenesis of Vigabatrin-associated visual field defects may be an idiosyncratic adverse drug reaction rather than dose-dependent toxicity.	Vigabatrin	toxicity	15094729	-1
-Assessment by conventional static perimetry may neither be sufficiently sensitive nor specific to reliably identify retinal toxicity associated with VGB.	VGB	retinal toxicity	19815465	1
-With all second-generation OCs as the reference, the odds ratios for VTE were 3.49 (1.21-10.12) for desogestrel plus 20 g ethinyloestradiol and 1.18 (0.66-2.17) for the other third-generation progestagens.	progestagens	VTE	8996419	-1
-With all second-generation OCs as the reference, the odds ratios for VTE were 3.49 (1.21-10.12) for desogestrel plus 20 g ethinyloestradiol and 1.18 (0.66-2.17) for the other third-generation progestagens.	desogestrel	VTE	8996419	-1
-With all second-generation OCs as the reference, the odds ratios for VTE were 3.49 (1.21-10.12) for desogestrel plus 20 g ethinyloestradiol and 1.18 (0.66-2.17) for the other third-generation progestagens.	ethinyloestradiol	VTE	8996419	-1
-With all second-generation OCs as the reference, the odds ratios for VTE were 3.49 (1.21-10.12) for desogestrel plus 20 g ethinyloestradiol and 1.18 (0.66-2.17) for the other third-generation progestagens.	OCs	VTE	8996419	1
-Efficacy of everolimus (RAD001) in patients with advanced NSCLC previously treated with chemotherapy alone or with chemotherapy and EGFR inhibitors	everolimus	NSCLC	19549709	-1
-Efficacy of everolimus (RAD001) in patients with advanced NSCLC previously treated with chemotherapy alone or with chemotherapy and EGFR inhibitors	RAD001	NSCLC	19549709	-1
-Quinine-induced arrhythmia in a patient with severe malaria.	Quinine	arrhythmia	17297207	-1
-Quinine-induced arrhythmia in a patient with severe malaria.	Quinine	malaria	17297207	-1
-RESULTS: A total of 59 patients with cocaine-associated chest pain were evaluated.	cocaine	chest pain	19655282	1
-However, our findings for both liver cancer and follicular cell lymphoma warrant follow-up to better differentiate effects of metolachlor use from other factors.	metolachlor	liver cancer	26033014	-1
-Patients with this response more often had a history of hypertension and had higher resting systolic and diastolic BP before dobutamine infusion.	dobutamine	hypertension	9382023	1
-Haloperidol decreased the incidence of cocaine-induced seizures at the two highest doses, but the lowering of the mortality rate did not reach statistical significance at any dose.	Haloperidol	seizures	2625524	-1
-Nonalcoholic fatty liver disease during valproate therapy.	valproate	Nonalcoholic fatty liver disease	19184102	1
-A hemoglobin concentration of <10 g/dL was defined as ribavirin-induced anemia.	ribavirin	anemia	15482540	-1
-Valproic acid (VPA) is effective for the treatment of many types of epilepsy, but its use can be associated with an increase in body weight.	Valproic acid	epilepsy	19184102	-1
-Valproic acid (VPA) is effective for the treatment of many types of epilepsy, but its use can be associated with an increase in body weight.	VPA	epilepsy	19184102	-1
-Damage of substantia nigra pars reticulata during pilocarpine-induced status epilepticus in the rat: immunohistochemical study of neurons, astrocytes and serum-protein extravasation.	pilocarpine	status epilepticus	1756784	1
-After granisetron doses of 5, 10, 20, and 40 micrograms/kg, a major response (< or = two vomiting or retching episodes, and no antiemetic rescue) was recorded in 23%, 57%, 58%, and 60% of patients, respectively, and a complete response (no vomiting or retching, and no antiemetic rescue) in 18%, 41%, 40%, and 47% of patients, respectively.	granisetron	vomiting	7931490	-1
-After granisetron doses of 5, 10, 20, and 40 micrograms/kg, a major response (< or = two vomiting or retching episodes, and no antiemetic rescue) was recorded in 23%, 57%, 58%, and 60% of patients, respectively, and a complete response (no vomiting or retching, and no antiemetic rescue) in 18%, 41%, 40%, and 47% of patients, respectively.	granisetron	vomiting	7931490	-1
-We report a case of nonalcoholic fatty liver disease (NAFLD) arising in a child who developed obesity during VPA treatment.	VPA	nonalcoholic fatty liver disease	19184102	1
-Biochemical effects of Solidago virgaurea extract on experimental cardiotoxicity.	Solidago virgaurea extract	cardiotoxicity	23872883	-1
-A patient who developed paraplegia following the intrathecal instillation of methotrexate is discribed.	methotrexate	paraplegia	946593	1
-These results indicate that labetalol induces easily adjustable hypotension without compensatory tachycardia and rebound hypertension.	labetalol	tachycardia	2718706	-1
-These results indicate that labetalol induces easily adjustable hypotension without compensatory tachycardia and rebound hypertension.	labetalol	hypertension	2718706	-1
-These results indicate that labetalol induces easily adjustable hypotension without compensatory tachycardia and rebound hypertension.	labetalol	hypotension	2718706	1
-After the withdrawal of VPA therapy, our patient showed a significant weight loss, a decrease of body mass index, and normalization of metabolic and endocrine parameters; moreover, ultrasound measurements showed a complete normalization.	VPA	weight loss	19184102	-1
-The results revealed that the adult offspring kidneys in the PCE group exhibited glomerulosclerosis as well as interstitial fibrosis, accompanied by elevated levels of serum creatinine and urine protein.	creatinine	glomerulosclerosis	25986755	-1
-The results revealed that the adult offspring kidneys in the PCE group exhibited glomerulosclerosis as well as interstitial fibrosis, accompanied by elevated levels of serum creatinine and urine protein.	creatinine	fibrosis	25986755	-1
-The results revealed that the adult offspring kidneys in the PCE group exhibited glomerulosclerosis as well as interstitial fibrosis, accompanied by elevated levels of serum creatinine and urine protein.	PCE	glomerulosclerosis	25986755	-1
-The results revealed that the adult offspring kidneys in the PCE group exhibited glomerulosclerosis as well as interstitial fibrosis, accompanied by elevated levels of serum creatinine and urine protein.	PCE	fibrosis	25986755	1
-Nissl-staining and antibodies against the neuron-specific calcium-binding protein, parvalbumin, served to detect neuronal damage in SNR.	calcium	neuronal damage	1756784	-1
-The purpose of the present study was to determine if elevated reactive oxygen (ROS)/nitrogen species (RNS) reported to be present in adriamycin (ADR)-induced cardiotoxicity actually resulted in cardiomyocyte oxidative/nitrative damage, and to quantitatively determine the time course and subcellular localization of these postulated damage products using an in vivo approach.	adriamycin	cardiotoxicity	15605432	-1
-The purpose of the present study was to determine if elevated reactive oxygen (ROS)/nitrogen species (RNS) reported to be present in adriamycin (ADR)-induced cardiotoxicity actually resulted in cardiomyocyte oxidative/nitrative damage, and to quantitatively determine the time course and subcellular localization of these postulated damage products using an in vivo approach.	adriamycin	RNS	15605432	-1
-The purpose of the present study was to determine if elevated reactive oxygen (ROS)/nitrogen species (RNS) reported to be present in adriamycin (ADR)-induced cardiotoxicity actually resulted in cardiomyocyte oxidative/nitrative damage, and to quantitatively determine the time course and subcellular localization of these postulated damage products using an in vivo approach.	ADR)-induced	cardiotoxicity	15605432	-1
-The purpose of the present study was to determine if elevated reactive oxygen (ROS)/nitrogen species (RNS) reported to be present in adriamycin (ADR)-induced cardiotoxicity actually resulted in cardiomyocyte oxidative/nitrative damage, and to quantitatively determine the time course and subcellular localization of these postulated damage products using an in vivo approach.	ADR)-induced	RNS	15605432	-1
-The purpose of the present study was to determine if elevated reactive oxygen (ROS)/nitrogen species (RNS) reported to be present in adriamycin (ADR)-induced cardiotoxicity actually resulted in cardiomyocyte oxidative/nitrative damage, and to quantitatively determine the time course and subcellular localization of these postulated damage products using an in vivo approach.	oxygen	cardiotoxicity	15605432	-1
-The purpose of the present study was to determine if elevated reactive oxygen (ROS)/nitrogen species (RNS) reported to be present in adriamycin (ADR)-induced cardiotoxicity actually resulted in cardiomyocyte oxidative/nitrative damage, and to quantitatively determine the time course and subcellular localization of these postulated damage products using an in vivo approach.	oxygen	RNS	15605432	-1
-Although cocaine-associated myocardial ischemia can result from coronary vasoconstriction, patients with cocaine associated chest pain, a non-ischemic ECG, and a TIMI risk score <2 may be safely discharged from the ED after a negative coronary CTA with a low risk of 30-day adverse events.	cocaine	ischemic	19655282	-1
-Although cocaine-associated myocardial ischemia can result from coronary vasoconstriction, patients with cocaine associated chest pain, a non-ischemic ECG, and a TIMI risk score <2 may be safely discharged from the ED after a negative coronary CTA with a low risk of 30-day adverse events.	cocaine	myocardial ischemia	19655282	1
-Although cocaine-associated myocardial ischemia can result from coronary vasoconstriction, patients with cocaine associated chest pain, a non-ischemic ECG, and a TIMI risk score <2 may be safely discharged from the ED after a negative coronary CTA with a low risk of 30-day adverse events.	cocaine	ischemic	19655282	-1
-Although cocaine-associated myocardial ischemia can result from coronary vasoconstriction, patients with cocaine associated chest pain, a non-ischemic ECG, and a TIMI risk score <2 may be safely discharged from the ED after a negative coronary CTA with a low risk of 30-day adverse events.	cocaine	myocardial ischemia	19655282	1
-Hypotension induced by ATP was accompanied by significant decreases in mean pulmonary arterial pressure (p less than 0.001), central venous pressure (p less than 0.001), left ventricular end-diastolic pressure (p less than 0.001), total peripheral resistance (p less than 0.001), rate pressure product (p less than 0.001), total body oxygen consumption (p less than 0.05), and heart rate (p less than 0.001); all these variables returned normal within 30 min after ATP was stopped.	oxygen	Hypotension	7147232	-1
-Hypotension induced by ATP was accompanied by significant decreases in mean pulmonary arterial pressure (p less than 0.001), central venous pressure (p less than 0.001), left ventricular end-diastolic pressure (p less than 0.001), total peripheral resistance (p less than 0.001), rate pressure product (p less than 0.001), total body oxygen consumption (p less than 0.05), and heart rate (p less than 0.001); all these variables returned normal within 30 min after ATP was stopped.	ATP	Hypotension	7147232	1
-Hypotension induced by ATP was accompanied by significant decreases in mean pulmonary arterial pressure (p less than 0.001), central venous pressure (p less than 0.001), left ventricular end-diastolic pressure (p less than 0.001), total peripheral resistance (p less than 0.001), rate pressure product (p less than 0.001), total body oxygen consumption (p less than 0.05), and heart rate (p less than 0.001); all these variables returned normal within 30 min after ATP was stopped.	ATP	Hypotension	7147232	1
-BACKGROUND: Little is known about the possible role that smoking crack cocaine has on the incidence of HIV infection.	smoking crack cocaine	HIV infection	19841052	-1
-Sequential biological assays of IL-1, IL-2, TNF and PAF were performed during Ara-C infusion to ten patients, including the four who developed the syndrome.	Ara	TNF	8318674	-1
-Given the increasing use of crack cocaine, we sought to examine whether use of this illicit drug has become a risk factor for HIV infection.	crack cocaine	HIV infection	19841052	-1
-A muscarinic receptor blocker, atropine, disrupted haloperidol-induced catalepsy.	haloperidol	catalepsy	3925479	1
-A muscarinic receptor blocker, atropine, disrupted haloperidol-induced catalepsy.	atropine	catalepsy	3925479	-1
-We found that Ca(2+) overload lead to accelerated beating rhythm in adult rat ventricular myocytes and caused arrhythmia in conscious freely moving rats.	Ca(2	arrhythmia	24840785	-1
-Induction of rosaceiform dermatitis during treatment of facial inflammatory dermatoses with tacrolimus ointment.	tacrolimus	dermatitis	15096374	-1
-RESULTS: Controlled hypotension was achieved within a shorter period using laryngeal mask using lower rates of remifentanil infusion and lower total dose of remifentanil.	remifentanil	hypotension	19178808	1
-BACKGROUND: Tacrolimus ointment is increasingly used for anti-inflammatory treatment of sensitive areas such as the face, and recent observations indicate that the treatment is effective in steroid-aggravated rosacea and perioral dermatitis.	Tacrolimus	perioral dermatitis	15096374	-1
-BACKGROUND: Tacrolimus ointment is increasingly used for anti-inflammatory treatment of sensitive areas such as the face, and recent observations indicate that the treatment is effective in steroid-aggravated rosacea and perioral dermatitis.	steroid	perioral dermatitis	15096374	-1
-BACKGROUND: Tacrolimus ointment is increasingly used for anti-inflammatory treatment of sensitive areas such as the face, and recent observations indicate that the treatment is effective in steroid-aggravated rosacea and perioral dermatitis.	steroid	rosacea	15096374	-1
-Furthermore, there have been reports of thrombotic microangiopathy precipitated by cyclosporine in patients with SSc.	cyclosporine	thrombotic microangiopathy	22836123	1
-Furthermore, there have been reports of thrombotic microangiopathy precipitated by cyclosporine in patients with SSc.	cyclosporine	SSc	22836123	-1
-Depression, impulsiveness, sleep, and memory in past and present polydrug users of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy).	3,4-methylenedioxymethamphetamine	Depression	24114426	1
-Depression, impulsiveness, sleep, and memory in past and present polydrug users of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy).	3,4-methylenedioxymethamphetamine	impulsiveness	24114426	-1
-Depression, impulsiveness, sleep, and memory in past and present polydrug users of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy).	MDMA	Depression	24114426	1
-Depression, impulsiveness, sleep, and memory in past and present polydrug users of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy).	MDMA	impulsiveness	24114426	-1
-Depression, impulsiveness, sleep, and memory in past and present polydrug users of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy).	ecstasy	Depression	24114426	1
-Depression, impulsiveness, sleep, and memory in past and present polydrug users of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy).	ecstasy	impulsiveness	24114426	-1
-Twenty (56%) acetaminophen-induced ALF patients had a formal psychiatric diagnosis before LT (non-acetaminophen-induced ALF=0/35, CLD=2/34; P<0.01 for all) and nine (25%) had a previous suicide attempt.	acetaminophen	psychiatric diagnosis	20408947	-1
-Twenty (56%) acetaminophen-induced ALF patients had a formal psychiatric diagnosis before LT (non-acetaminophen-induced ALF=0/35, CLD=2/34; P<0.01 for all) and nine (25%) had a previous suicide attempt.	acetaminophen	ALF=0/35	20408947	1
-Twenty (56%) acetaminophen-induced ALF patients had a formal psychiatric diagnosis before LT (non-acetaminophen-induced ALF=0/35, CLD=2/34; P<0.01 for all) and nine (25%) had a previous suicide attempt.	acetaminophen	CLD=2/34	20408947	-1
-Twenty (56%) acetaminophen-induced ALF patients had a formal psychiatric diagnosis before LT (non-acetaminophen-induced ALF=0/35, CLD=2/34; P<0.01 for all) and nine (25%) had a previous suicide attempt.	acetaminophen	psychiatric diagnosis	20408947	-1
-Twenty (56%) acetaminophen-induced ALF patients had a formal psychiatric diagnosis before LT (non-acetaminophen-induced ALF=0/35, CLD=2/34; P<0.01 for all) and nine (25%) had a previous suicide attempt.	acetaminophen	ALF	20408947	1
-Twenty (56%) acetaminophen-induced ALF patients had a formal psychiatric diagnosis before LT (non-acetaminophen-induced ALF=0/35, CLD=2/34; P<0.01 for all) and nine (25%) had a previous suicide attempt.	acetaminophen	CLD=2/34	20408947	-1
-The present case is the first carcinoma of the renal pelvis reported in association with cyclophosphamide treatment.	cyclophosphamide	carcinoma of the renal pelvis	7248895	-1
-OBSERVATIONS: Six adult patients with inflammatory facial dermatoses were treated with tacrolimus ointment because of the ineffectiveness of standard treatments.	tacrolimus	inflammatory facial dermatoses	15096374	-1
-They all exhibited markedly reduced plasma catecholamines and plasma renin activity in both recumbent and upright positions and had marked hypersensitivity to the pressor effects of infused norepinephrine.	catecholamines	hypersensitivity	611664	-1
-They all exhibited markedly reduced plasma catecholamines and plasma renin activity in both recumbent and upright positions and had marked hypersensitivity to the pressor effects of infused norepinephrine.	norepinephrine	hypersensitivity	611664	-1
-Minocycline-induced vasculitis fulfilling the criteria of polyarteritis nodosa.	Minocycline	vasculitis	16906379	-1
-Minocycline-induced vasculitis fulfilling the criteria of polyarteritis nodosa.	Minocycline	polyarteritis nodosa	16906379	1
-After the control ISO infusion with stenosis was performed, equihypotensive doses of CD-832 (3 and 10 micrograms/kg/min, n = 7), nifedipine (1 and 3 micrograms/kg/min, n = 9) or diltiazem (10 and 30 micrograms/kg/min, n = 7) were infused 5 min before and during the second and third ISO infusion.	diltiazem	stenosis	8819482	-1
-After the control ISO infusion with stenosis was performed, equihypotensive doses of CD-832 (3 and 10 micrograms/kg/min, n = 7), nifedipine (1 and 3 micrograms/kg/min, n = 9) or diltiazem (10 and 30 micrograms/kg/min, n = 7) were infused 5 min before and during the second and third ISO infusion.	ISO	stenosis	8819482	-1
-After the control ISO infusion with stenosis was performed, equihypotensive doses of CD-832 (3 and 10 micrograms/kg/min, n = 7), nifedipine (1 and 3 micrograms/kg/min, n = 9) or diltiazem (10 and 30 micrograms/kg/min, n = 7) were infused 5 min before and during the second and third ISO infusion.	ISO	stenosis	8819482	-1
-After the control ISO infusion with stenosis was performed, equihypotensive doses of CD-832 (3 and 10 micrograms/kg/min, n = 7), nifedipine (1 and 3 micrograms/kg/min, n = 9) or diltiazem (10 and 30 micrograms/kg/min, n = 7) were infused 5 min before and during the second and third ISO infusion.	nifedipine	stenosis	8819482	-1
-A 69-year-old man operated for acute cholecystitis under methoxyflurane anesthesia developed postoperatively a hepatic insufficiency syndrome and renal tubular acidosis.	methoxyflurane	hepatic insufficiency syndrome	6985498	-1
-A 69-year-old man operated for acute cholecystitis under methoxyflurane anesthesia developed postoperatively a hepatic insufficiency syndrome and renal tubular acidosis.	methoxyflurane	acute cholecystitis	6985498	-1
-A 69-year-old man operated for acute cholecystitis under methoxyflurane anesthesia developed postoperatively a hepatic insufficiency syndrome and renal tubular acidosis.	methoxyflurane	renal tubular acidosis	6985498	1
-In this article, we report a patient with SRC induced by tacrolimus and corticosteroids.	tacrolimus	SRC	22836123	-1
-In this article, we report a patient with SRC induced by tacrolimus and corticosteroids.	corticosteroids	SRC	22836123	-1
-RESULTS: We observed positive associations of Parkinson's disease with ozone (odds ratio = 1.39; 95% CI: 0.98 to 1.98) and fine particulate matter (odds ratio = 1.34; 95% CI: 0.93 to 1.93) in North Carolina but not in Iowa.	ozone	Parkinson's disease	25951420	1
-A 47-year-old man who had been taking minocycline for palmoplantar pustulosis developed fever, myalgias, polyneuropathy, and testicular pain, with elevated C-reactive protein (CRP).	minocycline	pain	16906379	-1
-A 47-year-old man who had been taking minocycline for palmoplantar pustulosis developed fever, myalgias, polyneuropathy, and testicular pain, with elevated C-reactive protein (CRP).	minocycline	fever	16906379	-1
-A 47-year-old man who had been taking minocycline for palmoplantar pustulosis developed fever, myalgias, polyneuropathy, and testicular pain, with elevated C-reactive protein (CRP).	minocycline	palmoplantar pustulosis	16906379	-1
-A 47-year-old man who had been taking minocycline for palmoplantar pustulosis developed fever, myalgias, polyneuropathy, and testicular pain, with elevated C-reactive protein (CRP).	minocycline	polyneuropathy	16906379	-1
-A 47-year-old man who had been taking minocycline for palmoplantar pustulosis developed fever, myalgias, polyneuropathy, and testicular pain, with elevated C-reactive protein (CRP).	minocycline	myalgias	16906379	-1
-The role of methotrexate contaminants, local folate deficiency, and cranial irradiation in the pathogenesis of intrathecal methotrexate toxicity is unclear.	methotrexate	toxicity	946593	-1
-The role of methotrexate contaminants, local folate deficiency, and cranial irradiation in the pathogenesis of intrathecal methotrexate toxicity is unclear.	methotrexate	toxicity	946593	-1
-The role of methotrexate contaminants, local folate deficiency, and cranial irradiation in the pathogenesis of intrathecal methotrexate toxicity is unclear.	folate	toxicity	946593	-1
-The present study was designed to investigate the cardioprotective effects of betaine on acute myocardial ischemia induced experimentally in rats focusing on regulation of signal transducer and activator of transcription 3 (STAT3) and apoptotic pathways as the potential mechanism underlying the drug effect.	betaine	myocardial ischemia	25080425	-1
-CONCLUSIONS: Our updated evaluation of diazinon provides additional evidence of an association with lung cancer risk.	diazinon	lung cancer	25907210	1
-S-312, S-312-d, but not S-312-l, L-type calcium channel antagonists, showed anticonvulsant effects on the audiogenic tonic convulsions in DBA/2 mice; and their ED50 values were 18.4 (12.8-27.1) mg/kg, p.o. and 15.0 (10.2-23.7) mg/kg, p.o., respectively, while that of flunarizine was 34.0 (26.0-44.8	flunarizine	tonic convulsions	7967231	-1
-S-312, S-312-d, but not S-312-l, L-type calcium channel antagonists, showed anticonvulsant effects on the audiogenic tonic convulsions in DBA/2 mice; and their ED50 values were 18.4 (12.8-27.1) mg/kg, p.o. and 15.0 (10.2-23.7) mg/kg, p.o., respectively, while that of flunarizine was 34.0 (26.0-44.8	S-312-d	tonic convulsions	7967231	-1
-S-312, S-312-d, but not S-312-l, L-type calcium channel antagonists, showed anticonvulsant effects on the audiogenic tonic convulsions in DBA/2 mice; and their ED50 values were 18.4 (12.8-27.1) mg/kg, p.o. and 15.0 (10.2-23.7) mg/kg, p.o., respectively, while that of flunarizine was 34.0 (26.0-44.8	calcium	tonic convulsions	7967231	-1
-CONCLUSION: In summary, our results indicate that airway management using FRLMA during controlled hypotension anesthesia provided better surgical conditions in terms of quality of operative field and blood loss and allowed for convenient induced hypotension with low doses of remifentanil during TIVA in patients undergoing FESS.	remifentanil	hypotension	19178808	1
-CONCLUSION: In summary, our results indicate that airway management using FRLMA during controlled hypotension anesthesia provided better surgical conditions in terms of quality of operative field and blood loss and allowed for convenient induced hypotension with low doses of remifentanil during TIVA in patients undergoing FESS.	remifentanil	blood loss	19178808	-1
-All-trans retinoic acid-induced inflammatory myositis in a patient with acute promyelocytic leukemia.	All-trans retinoic acid	inflammatory myositis	24658375	1
-All-trans retinoic acid-induced inflammatory myositis in a patient with acute promyelocytic leukemia.	All-trans retinoic acid	acute promyelocytic leukemia	24658375	-1
-Those patients in whom d,l-sotalol prevented induction of ventricular tachycardia or ventricular fibrillation were discharged with the drug and followed up on an outpatient basis for 21 +/-	l-sotalol	ventricular fibrillation	9125676	-1
-Those patients in whom d,l-sotalol prevented induction of ventricular tachycardia or ventricular fibrillation were discharged with the drug and followed up on an outpatient basis for 21 +/-	l-sotalol	ventricular tachycardia	9125676	-1
-Intradermal glutamate and capsaicin injections: intra- and interindividual variability of provoked hyperalgesia and allodynia.	capsaicin	allodynia	24684312	1
-Hypertensive response during dobutamine stress echocardiography.	dobutamine	Hypertensive	9382023	1
-Hyperprolactinemia was induced by treatment with haloperidol, a dopamine receptor antagonist, and Palkovits' microdissection technique in combination with high-performance liquid chromatography was used to measure neurotransmitter concentrations in several areas of the brain.	dopamine	Hyperprolactinemia	9128918	-1
-A frequently fatal, although exceptionally rare side effect of carbamazepine is necrotizing eosinophilic (hypersensitivity) myocarditis.	carbamazepine	myocarditis	20129423	1
-RESULTS: As described earlier, administration of ibuprofen was followed by a decrease in tonic pain but-relative to placebo-an increase in correlates of phasic pain, indicating a specific effect of ibuprofen on the interaction between the pain stimuli under these special experimental conditions.	ibuprofen	tonic pain	9272404	1
-RESULTS: As described earlier, administration of ibuprofen was followed by a decrease in tonic pain but-relative to placebo-an increase in correlates of phasic pain, indicating a specific effect of ibuprofen on the interaction between the pain stimuli under these special experimental conditions.	ibuprofen	pain	9272404	1
-RESULTS: As described earlier, administration of ibuprofen was followed by a decrease in tonic pain but-relative to placebo-an increase in correlates of phasic pain, indicating a specific effect of ibuprofen on the interaction between the pain stimuli under these special experimental conditions.	ibuprofen	pain	9272404	1
-PURPOSE: The case of an oncology patient who developed heparin-induced thrombocytopenia with thrombosis (HITT) and was treated with argatroban plus catheter-directed thrombolysis (CDT) with alteplase is presented.	heparin	thrombosis	24733133	-1
-PURPOSE: The case of an oncology patient who developed heparin-induced thrombocytopenia with thrombosis (HITT) and was treated with argatroban plus catheter-directed thrombolysis (CDT) with alteplase is presented.	heparin	HITT	24733133	-1
-PURPOSE: The case of an oncology patient who developed heparin-induced thrombocytopenia with thrombosis (HITT) and was treated with argatroban plus catheter-directed thrombolysis (CDT) with alteplase is presented.	argatroban	thrombocytopenia	24733133	-1
-PURPOSE: The case of an oncology patient who developed heparin-induced thrombocytopenia with thrombosis (HITT) and was treated with argatroban plus catheter-directed thrombolysis (CDT) with alteplase is presented.	argatroban	thrombosis	24733133	-1
-PURPOSE: The case of an oncology patient who developed heparin-induced thrombocytopenia with thrombosis (HITT) and was treated with argatroban plus catheter-directed thrombolysis (CDT) with alteplase is presented.	argatroban	HITT	24733133	-1
-To our knowledge, this is the second case of minocycline-induced vasculitis satisfying the criteria.	minocycline	vasculitis	16906379	-1
-Association of DRD2 polymorphisms and chlorpromazine-induced extrapyramidal syndrome in Chinese schizophrenic patients.	chlorpromazine	schizophrenic	16867246	-1
-Doxorubicin-induced cardiotoxicity monitored by ECG in freely moving mice.	Doxorubicin	cardiotoxicity	8603459	1
-Effects of dehydroepiandrosterone in amphetamine-induced schizophrenia models in mice.	dehydroepiandrosterone	schizophrenia	24739405	-1
-Effects of dehydroepiandrosterone in amphetamine-induced schizophrenia models in mice.	amphetamine	schizophrenia	24739405	1
-These data suggest a protective role for the central dopamine blocker haloperidol against death from high-dose amphetamine exposure without reducing the incidence of seizures.	dopamine	seizures	2625524	-1
-These data suggest a protective role for the central dopamine blocker haloperidol against death from high-dose amphetamine exposure without reducing the incidence of seizures.	dopamine	death	2625524	-1
-These data suggest a protective role for the central dopamine blocker haloperidol against death from high-dose amphetamine exposure without reducing the incidence of seizures.	haloperidol	seizures	2625524	-1
-These data suggest a protective role for the central dopamine blocker haloperidol against death from high-dose amphetamine exposure without reducing the incidence of seizures.	haloperidol	death	2625524	-1
-These data suggest a protective role for the central dopamine blocker haloperidol against death from high-dose amphetamine exposure without reducing the incidence of seizures.	amphetamine	seizures	2625524	1
-These data suggest a protective role for the central dopamine blocker haloperidol against death from high-dose amphetamine exposure without reducing the incidence of seizures.	amphetamine	death	2625524	-1
-Gemfibrozil-lovastatin therapy for primary hyperlipoproteinemias.	Gemfibrozil-lovastatin	hyperlipoproteinemias	1615846	-1
-However, DCF continued to be effective in reducing pelvic pain for two hours, whereas GTN scores remained more or less stable after 30 min and significantly higher than those for DFC (after one hour: GTN, -12.8 +/-	GTN	pelvic pain	11915580	-1
-However, DCF continued to be effective in reducing pelvic pain for two hours, whereas GTN scores remained more or less stable after 30 min and significantly higher than those for DFC (after one hour: GTN, -12.8 +/-	GTN	pelvic pain	11915580	-1
-However, DCF continued to be effective in reducing pelvic pain for two hours, whereas GTN scores remained more or less stable after 30 min and significantly higher than those for DFC (after one hour: GTN, -12.8 +/-	DCF	pelvic pain	11915580	-1
-The specific aim of this retrospective, observational study was to assess safety and efficacy of long-term (21 months/patient), open-label, gemfibrozil-lovastatin treatment in 80 patients with primary mixed hyperlipidemia (68% of whom had atherosclerotic vascular disease).	gemfibrozil-lovastatin	hyperlipidemia	1615846	-1
-The specific aim of this retrospective, observational study was to assess safety and efficacy of long-term (21 months/patient), open-label, gemfibrozil-lovastatin treatment in 80 patients with primary mixed hyperlipidemia (68% of whom had atherosclerotic vascular disease).	gemfibrozil-lovastatin	atherosclerotic vascular disease	1615846	-1
-Myositis, attributable to the drug combination and symptomatic enough to discontinue it, occurred in 3% of patients, and in 1% with concurrent high creatine phosphokinase (769 U/liter); no patients had rhabdomyolysis or myoglobinuria.(ABSTRACT TRUNCATED AT 250 WORDS)	creatine	Myositis	1615846	-1
-Myositis, attributable to the drug combination and symptomatic enough to discontinue it, occurred in 3% of patients, and in 1% with concurrent high creatine phosphokinase (769 U/liter); no patients had rhabdomyolysis or myoglobinuria.(ABSTRACT TRUNCATED AT 250 WORDS)	creatine	rhabdomyolysis	1615846	-1
-Myositis, attributable to the drug combination and symptomatic enough to discontinue it, occurred in 3% of patients, and in 1% with concurrent high creatine phosphokinase (769 U/liter); no patients had rhabdomyolysis or myoglobinuria.(ABSTRACT TRUNCATED AT 250 WORDS)	creatine	myoglobinuria.(ABSTRACT	1615846	-1
-CONCLUSION: Ureteric obstruction caused by precipitated indinavir crystals may be difficult to diagnose with unenhanced CT.	indinavir	Ureteric obstruction	9725303	-1
-For capsaicin, secondary pinprick hyperalgesia was detected with all von Frey gauges (P < 0.001).	capsaicin	pinprick hyperalgesia	24684312	1
-He was found to have atrial flutter at a ventricular rate of 70/min which slowed down to 30-40/min when nifedipine (60 mg) in 3 divided doses, during which he was paced at a rate of 70/min.	nifedipine	atrial flutter	2614930	-1
-Intramuscular hepatitis B immune globulin combined with lamivudine in prevention of hepatitis B recurrence after liver transplantation.	lamivudine	hepatitis B	16911931	-1
-Intramuscular hepatitis B immune globulin combined with lamivudine in prevention of hepatitis B recurrence after liver transplantation.	lamivudine	hepatitis B	16911931	-1
-Propylthiouracil-induced hepatic damage.	Propylthiouracil	hepatic damage	6893265	1
-The results indicated that exercise reduced the mortality associated with the effects of large dosages of isoproterenol but had little on the severity of the infarction.	isoproterenol	infarction	895432	-1
-Continuously nebulized albuterol in severe exacerbations of asthma in adults: a case-controlled study.	albuterol	asthma	9428298	-1
-We presented a patient admitted to our out-patient clinic with diffuse skeletal pain after three consecutive administration of alendronate.	alendronate	skeletal pain	20927253	1
-BACKGROUND: Combined hepatitis B immune globulin (HBIg) and lamivudine in prophylaxis of the recurrence of hepatitis B after liver transplantation has significantly improved the survival of HBsAg positive patients.	lamivudine	hepatitis B	16911931	-1
-BACKGROUND: Combined hepatitis B immune globulin (HBIg) and lamivudine in prophylaxis of the recurrence of hepatitis B after liver transplantation has significantly improved the survival of HBsAg positive patients.	lamivudine	hepatitis B	16911931	-1
-BACKGROUND: Combined hepatitis B immune globulin (HBIg) and lamivudine in prophylaxis of the recurrence of hepatitis B after liver transplantation has significantly improved the survival of HBsAg positive patients.	HBsAg	hepatitis B	16911931	-1
-BACKGROUND: Combined hepatitis B immune globulin (HBIg) and lamivudine in prophylaxis of the recurrence of hepatitis B after liver transplantation has significantly improved the survival of HBsAg positive patients.	HBsAg	hepatitis B	16911931	-1
-In humans, the intracoronary infusion of cocaine sufficient in amount to achieve a high drug concentration in coronary sinus blood causes a deterioration of LV systolic and diastolic performance.	cocaine	LV	9570197	1
-The purpose of this investigation was to determine whether the neurotoxicity of theophylline is altered in advanced pregnancy.	theophylline	neurotoxicity	3339945	-1
-DOX-induced cardiac damage presumably results from the formation of free radicals by DOX.	DOX	cardiac damage	16565833	-1
-DOX-induced cardiac damage presumably results from the formation of free radicals by DOX.	DOX	cardiac damage	16565833	-1
-STUDY HYPOTHESIS: Administration of the benzodiazepine antagonist flumazenil may unmask seizures in mixed cocaine-benzodiazepine intoxication.	benzodiazepine	seizures	8135424	-1
-STUDY HYPOTHESIS: Administration of the benzodiazepine antagonist flumazenil may unmask seizures in mixed cocaine-benzodiazepine intoxication.	cocaine-benzodiazepine	seizures	8135424	-1
-Central cardiovascular effects of AVP and ANP in normotensive and spontaneously hypertensive rats.	AVP	hypertensive	8188982	-1
-After the administration of nifekalant hydrochloride, sustained VT was terminated.	nifekalant hydrochloride	VT	15609701	-1
-The semisynthetic flavonoid monohydroxyethylrutoside (monoHER) showed cardioprotection against DOX-induced cardiotoxicity through its radical scavenging and iron chelating properties.	DOX	cardiotoxicity	16565833	-1
-The semisynthetic flavonoid monohydroxyethylrutoside (monoHER) showed cardioprotection against DOX-induced cardiotoxicity through its radical scavenging and iron chelating properties.	iron	cardiotoxicity	16565833	-1
-The semisynthetic flavonoid monohydroxyethylrutoside (monoHER) showed cardioprotection against DOX-induced cardiotoxicity through its radical scavenging and iron chelating properties.	flavonoid monohydroxyethylrutoside	cardiotoxicity	16565833	-1
-. RESULTS: Of 29 patients who received lidocaine in the setting of cocaine-associated MI, no patient died; exhibited bradydysrhythmias, ventricular tachycardia, or ventricular fibrillation; or experienced seizures after administration of lidocaine (95% confidence interval, 0% to 11%).	lidocaine	ventricular fibrillation	7492040	-1
-. RESULTS: Of 29 patients who received lidocaine in the setting of cocaine-associated MI, no patient died; exhibited bradydysrhythmias, ventricular tachycardia, or ventricular fibrillation; or experienced seizures after administration of lidocaine (95% confidence interval, 0% to 11%).	lidocaine	MI	7492040	-1
-. RESULTS: Of 29 patients who received lidocaine in the setting of cocaine-associated MI, no patient died; exhibited bradydysrhythmias, ventricular tachycardia, or ventricular fibrillation; or experienced seizures after administration of lidocaine (95% confidence interval, 0% to 11%).	lidocaine	seizures	7492040	-1
-. RESULTS: Of 29 patients who received lidocaine in the setting of cocaine-associated MI, no patient died; exhibited bradydysrhythmias, ventricular tachycardia, or ventricular fibrillation; or experienced seizures after administration of lidocaine (95% confidence interval, 0% to 11%).	lidocaine	ventricular tachycardia	7492040	-1
-. RESULTS: Of 29 patients who received lidocaine in the setting of cocaine-associated MI, no patient died; exhibited bradydysrhythmias, ventricular tachycardia, or ventricular fibrillation; or experienced seizures after administration of lidocaine (95% confidence interval, 0% to 11%).	lidocaine	ventricular fibrillation	7492040	-1
-. RESULTS: Of 29 patients who received lidocaine in the setting of cocaine-associated MI, no patient died; exhibited bradydysrhythmias, ventricular tachycardia, or ventricular fibrillation; or experienced seizures after administration of lidocaine (95% confidence interval, 0% to 11%).	lidocaine	MI	7492040	-1
-. RESULTS: Of 29 patients who received lidocaine in the setting of cocaine-associated MI, no patient died; exhibited bradydysrhythmias, ventricular tachycardia, or ventricular fibrillation; or experienced seizures after administration of lidocaine (95% confidence interval, 0% to 11%).	lidocaine	seizures	7492040	-1
-. RESULTS: Of 29 patients who received lidocaine in the setting of cocaine-associated MI, no patient died; exhibited bradydysrhythmias, ventricular tachycardia, or ventricular fibrillation; or experienced seizures after administration of lidocaine (95% confidence interval, 0% to 11%).	lidocaine	ventricular tachycardia	7492040	-1
-. RESULTS: Of 29 patients who received lidocaine in the setting of cocaine-associated MI, no patient died; exhibited bradydysrhythmias, ventricular tachycardia, or ventricular fibrillation; or experienced seizures after administration of lidocaine (95% confidence interval, 0% to 11%).	cocaine	ventricular fibrillation	7492040	-1
-. RESULTS: Of 29 patients who received lidocaine in the setting of cocaine-associated MI, no patient died; exhibited bradydysrhythmias, ventricular tachycardia, or ventricular fibrillation; or experienced seizures after administration of lidocaine (95% confidence interval, 0% to 11%).	cocaine	seizures	7492040	-1
-. RESULTS: Of 29 patients who received lidocaine in the setting of cocaine-associated MI, no patient died; exhibited bradydysrhythmias, ventricular tachycardia, or ventricular fibrillation; or experienced seizures after administration of lidocaine (95% confidence interval, 0% to 11%).	cocaine	ventricular tachycardia	7492040	-1
-The results demonstrate that the threshold for pilocarpine-induced seizures in rats is subjected to the regulation of the GABA-mediated synaptic inhibition within the substantia nigra.	GABA	seizures	3708328	-1
-The results demonstrate that the threshold for pilocarpine-induced seizures in rats is subjected to the regulation of the GABA-mediated synaptic inhibition within the substantia nigra.	pilocarpine	seizures	3708328	1
-Intracranial injection of an acetylcholine-synthesis inhibitor, hemicholinium, prevented the catalepsy that is usually induced by haloperidol.	acetylcholine	catalepsy	3925479	-1
-Intracranial injection of an acetylcholine-synthesis inhibitor, hemicholinium, prevented the catalepsy that is usually induced by haloperidol.	hemicholinium	catalepsy	3925479	-1
-Intracranial injection of an acetylcholine-synthesis inhibitor, hemicholinium, prevented the catalepsy that is usually induced by haloperidol.	haloperidol	catalepsy	3925479	1
-Intravenous inoculation of 4.2 x 10(10) to 7.8 x 10(10) pyocin type 6 Pseudomonas organisms in monkeys given vincristine sulfate 4 days previously resulted in fatal infection in 11 of 14 monkeys, whereas none of four receiving Pseudomonas alone died.	vincristine sulfate	infection	4631913	-1
-In this study, we evaluate the role DRD2 plays in chlorpromazine-induced EPS in schizophrenic patients.	chlorpromazine	schizophrenic	16867246	-1
-Effects of exercise on the severity of isoproterenol-induced myocardial infarction.	isoproterenol	myocardial infarction	895432	1
-Blockade of histamine H1 receptors may reduce mortality in pertussis immunization-induced encephalopathy in mice.	histamine	encephalopathy	2884595	-1
-Microscopic evaluation revealed that treatment with DOX alone induced significant cardiac damage in comparison to the saline control group (P<0.001).	DOX	cardiac damage	16565833	-1
-During follow-up (median 5 years), there were no significant differences in rejection (acute and chronic), graft failure or survival between the groups (acetaminophen-induced ALF 1 year 87%, 5 years 75%; non-acetaminophen-induced ALF 88%, 78%; CLD 93%, 82%: P>0.6 log rank).	acetaminophen	CLD	20408947	-1
-During follow-up (median 5 years), there were no significant differences in rejection (acute and chronic), graft failure or survival between the groups (acetaminophen-induced ALF 1 year 87%, 5 years 75%; non-acetaminophen-induced ALF 88%, 78%; CLD 93%, 82%: P>0.6 log rank).	acetaminophen	ALF	20408947	1
-During follow-up (median 5 years), there were no significant differences in rejection (acute and chronic), graft failure or survival between the groups (acetaminophen-induced ALF 1 year 87%, 5 years 75%; non-acetaminophen-induced ALF 88%, 78%; CLD 93%, 82%: P>0.6 log rank).	acetaminophen	ALF	20408947	1
-During follow-up (median 5 years), there were no significant differences in rejection (acute and chronic), graft failure or survival between the groups (acetaminophen-induced ALF 1 year 87%, 5 years 75%; non-acetaminophen-induced ALF 88%, 78%; CLD 93%, 82%: P>0.6 log rank).	acetaminophen	graft failure	20408947	-1
-During follow-up (median 5 years), there were no significant differences in rejection (acute and chronic), graft failure or survival between the groups (acetaminophen-induced ALF 1 year 87%, 5 years 75%; non-acetaminophen-induced ALF 88%, 78%; CLD 93%, 82%: P>0.6 log rank).	acetaminophen	CLD	20408947	-1
-During follow-up (median 5 years), there were no significant differences in rejection (acute and chronic), graft failure or survival between the groups (acetaminophen-induced ALF 1 year 87%, 5 years 75%; non-acetaminophen-induced ALF 88%, 78%; CLD 93%, 82%: P>0.6 log rank).	acetaminophen	graft failure	20408947	-1
-The three significant predictors of dyskinesia were duration of levodopa therapy, onset age, and total daily levodopa dose.	levodopa	dyskinesia	23952588	1
-Fluconazole associated agranulocytosis and thrombocytopenia.	Fluconazole	agranulocytosis	24459006	1
-Fluconazole associated agranulocytosis and thrombocytopenia.	Fluconazole	thrombocytopenia	24459006	1
-Oral administration of 2,5-di-O-acetyl-D-glucaro-1,4-6,3-dilactone protected rats against renal failure induced by kanamycin-dextran.	2,5-di-O-acetyl-D-glucaro-1,4-6,3-dilactone	renal failure	931801	-1
-Oral administration of 2,5-di-O-acetyl-D-glucaro-1,4-6,3-dilactone protected rats against renal failure induced by kanamycin-dextran.	dextran	renal failure	931801	-1
-Oral administration of 2,5-di-O-acetyl-D-glucaro-1,4-6,3-dilactone protected rats against renal failure induced by kanamycin-dextran.	kanamycin	renal failure	931801	-1
-Treatment of WT mice with topical ocular 0.1% dexamethasone led to elevation of intraocular pressure (IOP), functional and structural loss of retinal ganglion cells, and axonal degeneration, resembling glucocorticoid-induced glaucoma in human patients.	dexamethasone	retinal	24691439	-1
-Treatment of WT mice with topical ocular 0.1% dexamethasone led to elevation of intraocular pressure (IOP), functional and structural loss of retinal ganglion cells, and axonal degeneration, resembling glucocorticoid-induced glaucoma in human patients.	dexamethasone	glaucoma	24691439	1
-Treatment of WT mice with topical ocular 0.1% dexamethasone led to elevation of intraocular pressure (IOP), functional and structural loss of retinal ganglion cells, and axonal degeneration, resembling glucocorticoid-induced glaucoma in human patients.	dexamethasone	axonal degeneration	24691439	1
-METHODS: We identified seven SNP(single nucleotide polymorphism) (-141Cins>del, TaqIB, TaqID, Ser311Cys, rs6275, rs6277 and TaqIA) in the DRD2 gene in 146 schizophrenic inpatients (59 with EPS and 87 without EPS according to the Simpson-Angus Scale) treated with chlorpromazine after 8 weeks.	chlorpromazine	EPS	16867246	1
-METHODS: We identified seven SNP(single nucleotide polymorphism) (-141Cins>del, TaqIB, TaqID, Ser311Cys, rs6275, rs6277 and TaqIA) in the DRD2 gene in 146 schizophrenic inpatients (59 with EPS and 87 without EPS according to the Simpson-Angus Scale) treated with chlorpromazine after 8 weeks.	chlorpromazine	schizophrenic	16867246	-1
-METHODS: We identified seven SNP(single nucleotide polymorphism) (-141Cins>del, TaqIB, TaqID, Ser311Cys, rs6275, rs6277 and TaqIA) in the DRD2 gene in 146 schizophrenic inpatients (59 with EPS and 87 without EPS according to the Simpson-Angus Scale) treated with chlorpromazine after 8 weeks.	SNP(single	EPS	16867246	-1
-METHODS: We identified seven SNP(single nucleotide polymorphism) (-141Cins>del, TaqIB, TaqID, Ser311Cys, rs6275, rs6277 and TaqIA) in the DRD2 gene in 146 schizophrenic inpatients (59 with EPS and 87 without EPS according to the Simpson-Angus Scale) treated with chlorpromazine after 8 weeks.	SNP(single	EPS	16867246	-1
-METHODS: We identified seven SNP(single nucleotide polymorphism) (-141Cins>del, TaqIB, TaqID, Ser311Cys, rs6275, rs6277 and TaqIA) in the DRD2 gene in 146 schizophrenic inpatients (59 with EPS and 87 without EPS according to the Simpson-Angus Scale) treated with chlorpromazine after 8 weeks.	SNP(single	schizophrenic	16867246	-1
-METHODS: We identified seven SNP(single nucleotide polymorphism) (-141Cins>del, TaqIB, TaqID, Ser311Cys, rs6275, rs6277 and TaqIA) in the DRD2 gene in 146 schizophrenic inpatients (59 with EPS and 87 without EPS according to the Simpson-Angus Scale) treated with chlorpromazine after 8 weeks.	nucleotide	EPS	16867246	-1
-METHODS: We identified seven SNP(single nucleotide polymorphism) (-141Cins>del, TaqIB, TaqID, Ser311Cys, rs6275, rs6277 and TaqIA) in the DRD2 gene in 146 schizophrenic inpatients (59 with EPS and 87 without EPS according to the Simpson-Angus Scale) treated with chlorpromazine after 8 weeks.	nucleotide	EPS	16867246	-1
-METHODS: We identified seven SNP(single nucleotide polymorphism) (-141Cins>del, TaqIB, TaqID, Ser311Cys, rs6275, rs6277 and TaqIA) in the DRD2 gene in 146 schizophrenic inpatients (59 with EPS and 87 without EPS according to the Simpson-Angus Scale) treated with chlorpromazine after 8 weeks.	nucleotide	schizophrenic	16867246	-1
-The patient developed acute encephalopathy evidenced by behavioral changes, aphasia, incontinence, visual hallucinations, and right-sided weakness with diffuse cerebral vasospasm on magnetic resonance angiography after the administration of intrathecal cytarabine.	cytarabine	incontinence	17356399	1
-The patient developed acute encephalopathy evidenced by behavioral changes, aphasia, incontinence, visual hallucinations, and right-sided weakness with diffuse cerebral vasospasm on magnetic resonance angiography after the administration of intrathecal cytarabine.	cytarabine	acute encephalopathy	17356399	-1
-Cases have been published of coronary vasospasm, myocardial ischemia, and myocardial infarction occurring after sumatriptan use.	sumatriptan	myocardial infarction	9759693	-1
-Cases have been published of coronary vasospasm, myocardial ischemia, and myocardial infarction occurring after sumatriptan use.	sumatriptan	coronary vasospasm	9759693	-1
-Cases have been published of coronary vasospasm, myocardial ischemia, and myocardial infarction occurring after sumatriptan use.	sumatriptan	myocardial ischemia	9759693	-1
-To investigate effects of aconitine on myocardial injury, we performed cytotoxicity assay in neonatal rat ventricular myocytes (NRVMs), as well as measured lactate dehydrogenase level in the culture medium of NRVMs and activities of serum cardiac enzymes in rats.	lactate	myocardial injury	24840785	-1
-To investigate effects of aconitine on myocardial injury, we performed cytotoxicity assay in neonatal rat ventricular myocytes (NRVMs), as well as measured lactate dehydrogenase level in the culture medium of NRVMs and activities of serum cardiac enzymes in rats.	lactate	cytotoxicity	24840785	-1
-To investigate effects of aconitine on myocardial injury, we performed cytotoxicity assay in neonatal rat ventricular myocytes (NRVMs), as well as measured lactate dehydrogenase level in the culture medium of NRVMs and activities of serum cardiac enzymes in rats.	aconitine	myocardial injury	24840785	-1
-To investigate effects of aconitine on myocardial injury, we performed cytotoxicity assay in neonatal rat ventricular myocytes (NRVMs), as well as measured lactate dehydrogenase level in the culture medium of NRVMs and activities of serum cardiac enzymes in rats.	aconitine	cytotoxicity	24840785	-1
-Cardioprotective effects of Picrorrhiza kurroa against isoproterenol-induced myocardial stress in rats.	isoproterenol	myocardial stress	11395263	-1
-The cardioprotective effect of the ethanol extract of Picrorrhiza kurroa rhizomes and roots (PK) on isoproterenol-induced myocardial infarction in rats with respect to lipid metabolism in serum and heart tissue has been investigated.	ethanol	myocardial infarction	11395263	-1
-We conclude that ATRA is a valid therapeutic choice for patients with APL, although the procoagulant tendency is not completely corrected.	ATRA	APL	9158667	-1
-Anticonvulsant effect of eslicarbazepine acetate (BIA 2-093) on seizures induced by microperfusion of picrotoxin in the hippocampus of freely moving rats.	eslicarbazepine acetate	seizures	16920333	-1
-Anticonvulsant effect of eslicarbazepine acetate (BIA 2-093) on seizures induced by microperfusion of picrotoxin in the hippocampus of freely moving rats.	BIA 2-093	seizures	16920333	-1
-After 6 months of hyperprolactinemia, dopamine (DA) concentrations in the median eminence (ME) increased by 84% over the control group.	dopamine	hyperprolactinemia	9128918	-1
-After 6 months of hyperprolactinemia, dopamine (DA) concentrations in the median eminence (ME) increased by 84% over the control group.	DA	hyperprolactinemia	9128918	-1
-Support for adrenaline-hypertension hypothesis: 18 hour pressor effect after 6 hours adrenaline infusion.	adrenaline	adrenaline-hypertension hypothesis	2904523	1
-BACKGROUND: This study examined the role of phase 2 early afterdepolarization (EAD) in producing a trigger to initiate torsade de pointes (TdP) with QT prolongation induced by dl-sotalol and azimilide.	azimilide	QT prolongation	11401944	-1
-BACKGROUND: This study examined the role of phase 2 early afterdepolarization (EAD) in producing a trigger to initiate torsade de pointes (TdP) with QT prolongation induced by dl-sotalol and azimilide.	azimilide	torsade de pointes	11401944	-1
-BACKGROUND: This study examined the role of phase 2 early afterdepolarization (EAD) in producing a trigger to initiate torsade de pointes (TdP) with QT prolongation induced by dl-sotalol and azimilide.	azimilide	TdP	11401944	-1
-In the animals treated with threshold doses of picrotoxin, the average number of seizures was 2.3+/-1.2, and average seizure duration was 39.5+/-8.4s.	picrotoxin	seizures	16920333	1
-In the animals treated with threshold doses of picrotoxin, the average number of seizures was 2.3+/-1.2, and average seizure duration was 39.5+/-8.4s.	picrotoxin	seizure	16920333	1
-We compared the toxicity of NS-718 with that of Fungizone (amphotericin B-sodium deoxycholate; D-AmB) in vitro using renal cell cultures and in vivo by biochemical analysis, histopathological study of the kidney and pharmacokinetic study of amphotericin B following intravenous infusion of the formulation in rats.	Fungizone	NS-718	10933650	-1
-We compared the toxicity of NS-718 with that of Fungizone (amphotericin B-sodium deoxycholate; D-AmB) in vitro using renal cell cultures and in vivo by biochemical analysis, histopathological study of the kidney and pharmacokinetic study of amphotericin B following intravenous infusion of the formulation in rats.	Fungizone	toxicity	10933650	-1
-We compared the toxicity of NS-718 with that of Fungizone (amphotericin B-sodium deoxycholate; D-AmB) in vitro using renal cell cultures and in vivo by biochemical analysis, histopathological study of the kidney and pharmacokinetic study of amphotericin B following intravenous infusion of the formulation in rats.	D-AmB	NS-718	10933650	-1
-We compared the toxicity of NS-718 with that of Fungizone (amphotericin B-sodium deoxycholate; D-AmB) in vitro using renal cell cultures and in vivo by biochemical analysis, histopathological study of the kidney and pharmacokinetic study of amphotericin B following intravenous infusion of the formulation in rats.	D-AmB	toxicity	10933650	-1
-We compared the toxicity of NS-718 with that of Fungizone (amphotericin B-sodium deoxycholate; D-AmB) in vitro using renal cell cultures and in vivo by biochemical analysis, histopathological study of the kidney and pharmacokinetic study of amphotericin B following intravenous infusion of the formulation in rats.	amphotericin B	NS-718	10933650	-1
-We compared the toxicity of NS-718 with that of Fungizone (amphotericin B-sodium deoxycholate; D-AmB) in vitro using renal cell cultures and in vivo by biochemical analysis, histopathological study of the kidney and pharmacokinetic study of amphotericin B following intravenous infusion of the formulation in rats.	amphotericin B	toxicity	10933650	-1
-We compared the toxicity of NS-718 with that of Fungizone (amphotericin B-sodium deoxycholate; D-AmB) in vitro using renal cell cultures and in vivo by biochemical analysis, histopathological study of the kidney and pharmacokinetic study of amphotericin B following intravenous infusion of the formulation in rats.	amphotericin B-sodium deoxycholate	NS-718	10933650	-1
-We compared the toxicity of NS-718 with that of Fungizone (amphotericin B-sodium deoxycholate; D-AmB) in vitro using renal cell cultures and in vivo by biochemical analysis, histopathological study of the kidney and pharmacokinetic study of amphotericin B following intravenous infusion of the formulation in rats.	amphotericin B-sodium deoxycholate	toxicity	10933650	-1
-Similar to the remnant kidney model in PAN nephrosis the development of glomerular sclerosis may be related to "mesangial overloading."	PAN	nephrosis	3990093	-1
-Similar to the remnant kidney model in PAN nephrosis the development of glomerular sclerosis may be related to "mesangial overloading."	PAN	glomerular sclerosis	3990093	-1
-Furthermore, apigenin did not prevent the amnesia induced by scopolamine (1mg/kg, i.p.	apigenin	amnesia	24284476	-1
-Furthermore, apigenin did not prevent the amnesia induced by scopolamine (1mg/kg, i.p.	scopolamine	amnesia	24284476	1
-Both isomers of propranolol were also capable of reversing ventricular tachycardia caused by ouabain in anaesthetized cats and dogs.	ouabain	ventricular tachycardia	19108278	1
-Both isomers of propranolol were also capable of reversing ventricular tachycardia caused by ouabain in anaesthetized cats and dogs.	propranolol	ventricular tachycardia	19108278	-1
-It is concluded that curcumin is able to attenuate in vivo maleate-induced nephropathy and in vitro cell damage.	maleate	nephropathy	25119790	-1
-It is concluded that curcumin is able to attenuate in vivo maleate-induced nephropathy and in vitro cell damage.	curcumin	nephropathy	25119790	-1
-CCB was reduced in WKY and SHR after LV administration of AVP during SN-induced hypotension.	AVP	hypotension	8188982	-1
-CCB was reduced in WKY and SHR after LV administration of AVP during SN-induced hypotension.	AVP	LV	8188982	-1
-CCB was reduced in WKY and SHR after LV administration of AVP during SN-induced hypotension.	SN	SHR	8188982	-1
-CCB was reduced in WKY and SHR after LV administration of AVP during SN-induced hypotension.	SN	hypotension	8188982	1
-CCB was reduced in WKY and SHR after LV administration of AVP during SN-induced hypotension.	SN	LV	8188982	-1
-CCB was reduced in WKY and SHR after LV administration of AVP during SN-induced hypotension.	CCB	SHR	8188982	-1
-CCB was reduced in WKY and SHR after LV administration of AVP during SN-induced hypotension.	CCB	hypotension	8188982	-1
-CCB was reduced in WKY and SHR after LV administration of AVP during SN-induced hypotension.	CCB	LV	8188982	-1
-The present study examines the safety and tolerability of high- compared with low-dose lisinopril in CHF.	lisinopril	CHF	11176729	-1
-Third, although it is relatively easy to block seizures induced by lithium and pilocarpine by administration of anticonvulsants prior to pilocarpine, it is more difficult to terminate ongoing status epilepticus and block the lethality of the seizures.	lithium	status epilepticus	2553470	1
-Third, although it is relatively easy to block seizures induced by lithium and pilocarpine by administration of anticonvulsants prior to pilocarpine, it is more difficult to terminate ongoing status epilepticus and block the lethality of the seizures.	lithium	seizures	2553470	-1
-Third, although it is relatively easy to block seizures induced by lithium and pilocarpine by administration of anticonvulsants prior to pilocarpine, it is more difficult to terminate ongoing status epilepticus and block the lethality of the seizures.	lithium	seizures	2553470	-1
-Third, although it is relatively easy to block seizures induced by lithium and pilocarpine by administration of anticonvulsants prior to pilocarpine, it is more difficult to terminate ongoing status epilepticus and block the lethality of the seizures.	pilocarpine	status epilepticus	2553470	1
-Third, although it is relatively easy to block seizures induced by lithium and pilocarpine by administration of anticonvulsants prior to pilocarpine, it is more difficult to terminate ongoing status epilepticus and block the lethality of the seizures.	pilocarpine	seizures	2553470	-1
-Third, although it is relatively easy to block seizures induced by lithium and pilocarpine by administration of anticonvulsants prior to pilocarpine, it is more difficult to terminate ongoing status epilepticus and block the lethality of the seizures.	pilocarpine	seizures	2553470	-1
-Third, although it is relatively easy to block seizures induced by lithium and pilocarpine by administration of anticonvulsants prior to pilocarpine, it is more difficult to terminate ongoing status epilepticus and block the lethality of the seizures.	pilocarpine	status epilepticus	2553470	1
-Third, although it is relatively easy to block seizures induced by lithium and pilocarpine by administration of anticonvulsants prior to pilocarpine, it is more difficult to terminate ongoing status epilepticus and block the lethality of the seizures.	pilocarpine	seizures	2553470	-1
-Third, although it is relatively easy to block seizures induced by lithium and pilocarpine by administration of anticonvulsants prior to pilocarpine, it is more difficult to terminate ongoing status epilepticus and block the lethality of the seizures.	pilocarpine	seizures	2553470	-1
-However, administration of nefiracetam during training completely reversed the amnesia induced by apomorphine at the 10h post-training time and the converse was also true.	nefiracetam	amnesia	8829135	-1
-An increase in TDR by dl-sotalol facilitated transmural propagation of EADs that initiated multiple episodes of spontaneous TdP in 3 of 6 rabbit left ventricles.	dl-sotalol	TdP	11401944	1
-Herein, we investigate whether doxorubicin-associated chronic cardiac toxicity can be ameliorated with the antioxidant hydroxytyrosol in rats with breast cancer.	doxorubicin	cardiac toxicity	24727461	-1
-Herein, we investigate whether doxorubicin-associated chronic cardiac toxicity can be ameliorated with the antioxidant hydroxytyrosol in rats with breast cancer.	doxorubicin	breast cancer	24727461	-1
-Herein, we investigate whether doxorubicin-associated chronic cardiac toxicity can be ameliorated with the antioxidant hydroxytyrosol in rats with breast cancer.	hydroxytyrosol	cardiac toxicity	24727461	-1
-Herein, we investigate whether doxorubicin-associated chronic cardiac toxicity can be ameliorated with the antioxidant hydroxytyrosol in rats with breast cancer.	hydroxytyrosol	breast cancer	24727461	-1
-RESULTS: Verapamil significantly increased PRL levels in healthy controls (N. 8, PRL: 183%), macroprolactinoma (N. 8, PRL: 7%), microprolactinoma (N. 19, PRL: 21%), macroprolactinemia (N. 23, PRL: 126%), but not in pseudoprolactinoma (N. 8, PRL: 0.8%), and risperidone-induced hyperprolactinemia (N. 7, PRL: 3%).	Verapamil	hyperprolactinemia	20595935	-1
-RESULTS: Verapamil significantly increased PRL levels in healthy controls (N. 8, PRL: 183%), macroprolactinoma (N. 8, PRL: 7%), microprolactinoma (N. 19, PRL: 21%), macroprolactinemia (N. 23, PRL: 126%), but not in pseudoprolactinoma (N. 8, PRL: 0.8%), and risperidone-induced hyperprolactinemia (N. 7, PRL: 3%).	Verapamil	macroprolactinoma	20595935	-1
-RESULTS: Verapamil significantly increased PRL levels in healthy controls (N. 8, PRL: 183%), macroprolactinoma (N. 8, PRL: 7%), microprolactinoma (N. 19, PRL: 21%), macroprolactinemia (N. 23, PRL: 126%), but not in pseudoprolactinoma (N. 8, PRL: 0.8%), and risperidone-induced hyperprolactinemia (N. 7, PRL: 3%).	Verapamil	microprolactinoma	20595935	-1
-RESULTS: Verapamil significantly increased PRL levels in healthy controls (N. 8, PRL: 183%), macroprolactinoma (N. 8, PRL: 7%), microprolactinoma (N. 19, PRL: 21%), macroprolactinemia (N. 23, PRL: 126%), but not in pseudoprolactinoma (N. 8, PRL: 0.8%), and risperidone-induced hyperprolactinemia (N. 7, PRL: 3%).	risperidone	hyperprolactinemia	20595935	1
-RESULTS: Verapamil significantly increased PRL levels in healthy controls (N. 8, PRL: 183%), macroprolactinoma (N. 8, PRL: 7%), microprolactinoma (N. 19, PRL: 21%), macroprolactinemia (N. 23, PRL: 126%), but not in pseudoprolactinoma (N. 8, PRL: 0.8%), and risperidone-induced hyperprolactinemia (N. 7, PRL: 3%).	risperidone	macroprolactinoma	20595935	-1
-RESULTS: Verapamil significantly increased PRL levels in healthy controls (N. 8, PRL: 183%), macroprolactinoma (N. 8, PRL: 7%), microprolactinoma (N. 19, PRL: 21%), macroprolactinemia (N. 23, PRL: 126%), but not in pseudoprolactinoma (N. 8, PRL: 0.8%), and risperidone-induced hyperprolactinemia (N. 7, PRL: 3%).	risperidone	microprolactinoma	20595935	-1
-Misoprostol has been associated with adverse reactions, including gastrointestinal symptoms, gynecologic problems, and headache.	Misoprostol	headache	1905439	-1
-Misoprostol has been associated with adverse reactions, including gastrointestinal symptoms, gynecologic problems, and headache.	Misoprostol	gastrointestinal symptoms	1905439	-1
-ROC curve analysis revealed that unresponsiveness to verapamil defined as PRL <7%, discriminated anatomical or functional stalk effect (sensitivity: 74%, specificity: 73%, AUC: 0.855+/-0.04, P <0.001, CI: 0.768-0.942) associated with pseudoprolactinoma or risperidone-induced hyperprolactinemia, respectively.	verapamil	hyperprolactinemia	20595935	-1
-ROC curve analysis revealed that unresponsiveness to verapamil defined as PRL <7%, discriminated anatomical or functional stalk effect (sensitivity: 74%, specificity: 73%, AUC: 0.855+/-0.04, P <0.001, CI: 0.768-0.942) associated with pseudoprolactinoma or risperidone-induced hyperprolactinemia, respectively.	risperidone	hyperprolactinemia	20595935	1
-We report a case of acute renal failure in an APL patient treated with ATRA alone.	ATRA	APL	9158667	-1
-PARTICIPANTS: Patients with cocaine-associated MI who received lidocaine in the emergency department	lidocaine	MI	7492040	-1
-RESULTS: Of 405 patients not previously receiving an ACE inhibitor, doses in only 4.2% could not be titrated to the medium doses required for randomization because of symptoms possibly related to hypotension (2.0%) or because of renal dysfunction or hyperkalemia (2.3%).	ACE inhibitor	hyperkalemia	11176729	-1
-RESULTS: Of 405 patients not previously receiving an ACE inhibitor, doses in only 4.2% could not be titrated to the medium doses required for randomization because of symptoms possibly related to hypotension (2.0%) or because of renal dysfunction or hyperkalemia (2.3%).	ACE inhibitor	renal dysfunction	11176729	-1
-RESULTS: Of 405 patients not previously receiving an ACE inhibitor, doses in only 4.2% could not be titrated to the medium doses required for randomization because of symptoms possibly related to hypotension (2.0%) or because of renal dysfunction or hyperkalemia (2.3%).	ACE inhibitor	hypotension	11176729	-1
-Myoclonic movements are evaluated, which were observed and graded according to clinical severity during the 2 minutes after etomidate injection.	etomidate	Myoclonic movements	24535067	-1
-Nonopaque crystal deposition causing ureteric obstruction in patients with HIV undergoing indinavir therapy.	indinavir	ureteric obstruction	9725303	-1
-CONCLUSION: Verapamil responsiveness is not a reliable finding for the differential diagnosis of hyperprolactinemia.	Verapamil	hyperprolactinemia	20595935	-1
-However, verapamil unresponsiveness discriminates stalk effect (i.e., anatomically or functionally inhibited dopaminergic tonus) from other causes of hyperprolactinemia with varying degrees of responsiveness.	verapamil	hyperprolactinemia	20595935	-1
-The presentation and cardiac evaluation (hemodynamic, echocardiographic, and scintigraphic) of these patients suggest new manifestations of 5-FU cardiotoxicity that may be influenced by CDDP.	5-FU	cardiotoxicity	3383127	-1
-The presentation and cardiac evaluation (hemodynamic, echocardiographic, and scintigraphic) of these patients suggest new manifestations of 5-FU cardiotoxicity that may be influenced by CDDP.	CDDP	cardiotoxicity	3383127	-1
-<120 mm Hg; creatinine, > or =132.6 micromol/L [> or =1.5 mg/dL]; age, > or =70 years; and patients with diabetes) generally tolerated the high-dose strategy.	creatinine	diabetes	11176729	-1
-This study was designed to evaluate the ameliorative effects of metformin on seizures, cognitive impairment and brain oxidative stress markers observed in pentylenetetrazole-induced kindling animals.	metformin	seizures	24802403	-1
-This study was designed to evaluate the ameliorative effects of metformin on seizures, cognitive impairment and brain oxidative stress markers observed in pentylenetetrazole-induced kindling animals.	metformin	cognitive impairment	24802403	-1
-This study was designed to evaluate the ameliorative effects of metformin on seizures, cognitive impairment and brain oxidative stress markers observed in pentylenetetrazole-induced kindling animals.	pentylenetetrazole	seizures	24802403	1
-Cardiac symptoms, including hypotension, developed in three patients with advanced colorectal carcinoma while being treated with cisplatin (CDDP) and 5-fluorouracil (5-FU).	5-fluorouracil	colorectal carcinoma	3383127	-1
-Cardiac symptoms, including hypotension, developed in three patients with advanced colorectal carcinoma while being treated with cisplatin (CDDP) and 5-fluorouracil (5-FU).	5-FU	colorectal carcinoma	3383127	-1
-Cardiac symptoms, including hypotension, developed in three patients with advanced colorectal carcinoma while being treated with cisplatin (CDDP) and 5-fluorouracil (5-FU).	5-FU	hypotension	3383127	1
-Cardiac symptoms, including hypotension, developed in three patients with advanced colorectal carcinoma while being treated with cisplatin (CDDP) and 5-fluorouracil (5-FU).	cisplatin	colorectal carcinoma	3383127	-1
-Cardiac symptoms, including hypotension, developed in three patients with advanced colorectal carcinoma while being treated with cisplatin (CDDP) and 5-fluorouracil (5-FU).	CDDP	colorectal carcinoma	3383127	-1
-These findings demonstrate that ACE inhibitor therapy in most patients with CHF can be successfully titrated to and maintained at high doses, and that more aggressive use of these agents is warranted.	ACE inhibitor	CHF	11176729	-1
-Comparison of valsartan/hydrochlorothiazide combination therapy at doses up to 320/25 mg versus monotherapy: a double-blind, placebo-controlled study followed by long-term combination therapy in hypertensive adults.	hydrochlorothiazide	hypertensive	17379047	-1
-Comparison of valsartan/hydrochlorothiazide combination therapy at doses up to 320/25 mg versus monotherapy: a double-blind, placebo-controlled study followed by long-term combination therapy in hypertensive adults.	valsartan	hypertensive	17379047	-1
-We found that metformin suppressed the progression of kindling, ameliorated the cognitive impairment and decreased brain oxidative stress.	metformin	cognitive impairment	24802403	-1
-CONCLUSIONS: Our observations suggest that the spectrum of rosaceiform dermatitis as a complication of treatment with tacrolimus ointment is heterogeneous.	tacrolimus	dermatitis	15096374	-1
-Two hundred thirty-five patients aged 76 and older admitted to a major healthcare network between July 1, 2001, and June 30, 2002, with atrial fibrillation on warfarin were enrolled.	warfarin	atrial fibrillation	15817013	-1
-Thus the present study concluded that metformin may be a potential agent for the treatment of epilepsy as well as a protective medicine against cognitive impairment induced by seizures.	metformin	seizures	24802403	-1
-Thus the present study concluded that metformin may be a potential agent for the treatment of epilepsy as well as a protective medicine against cognitive impairment induced by seizures.	metformin	cognitive impairment	24802403	-1
-Thus the present study concluded that metformin may be a potential agent for the treatment of epilepsy as well as a protective medicine against cognitive impairment induced by seizures.	metformin	epilepsy	24802403	-1
-Codeine catalepsy was increased by clonidine and decreased by naphazoline and xylometazoline.	clonidine	catalepsy	35781	1
-Codeine catalepsy was increased by clonidine and decreased by naphazoline and xylometazoline.	xylometazoline	catalepsy	35781	1
-Codeine catalepsy was increased by clonidine and decreased by naphazoline and xylometazoline.	naphazoline	catalepsy	35781	1
-MEASUREMENTS: Information regarding major bleeding episodes, strokes, and warfarin use was obtained from patients, relatives, primary physicians, and medical records.	warfarin	strokes	15817013	-1
-Flurothyl seizure thresholds in mice treated neonatally with a single injection of monosodium glutamate (MSG): evaluation of experimental parameters in flurothyl seizure testing.	Flurothyl	seizure	3685052	-1
-Flurothyl seizure thresholds in mice treated neonatally with a single injection of monosodium glutamate (MSG): evaluation of experimental parameters in flurothyl seizure testing.	Flurothyl	seizure	3685052	-1
-Flurothyl seizure thresholds in mice treated neonatally with a single injection of monosodium glutamate (MSG): evaluation of experimental parameters in flurothyl seizure testing.	flurothyl	seizure	3685052	-1
-Flurothyl seizure thresholds in mice treated neonatally with a single injection of monosodium glutamate (MSG): evaluation of experimental parameters in flurothyl seizure testing.	flurothyl	seizure	3685052	-1
-Although statins are generally well-tolerated drugs, recent cases of drug-induced liver injury associated with their use have been reported.	statins	liver injury	24451297	-1
-Two acetaminophen-induced ALF patients reattempted suicide post-LT (one died 8 years post-LT).	acetaminophen	ALF	20408947	1
-The annual stroke rate after initiation of warfarin was 2.6%.	warfarin	stroke	15817013	-1
-CONCLUSION: Aspirin reduces the risk for myocardial infarction in men and strokes in women.	Aspirin	myocardial infarction	19293073	-1
-CONCLUSION: Aspirin reduces the risk for myocardial infarction in men and strokes in women.	Aspirin	strokes	19293073	1
-CONCLUSION: The rate of major hemorrhage was high in this old, frail group, but excluding fatalities, resulted in no long-term sequelae, and the stroke rate on warfarin was low, demonstrating how effective warfarin treatment is.	warfarin	hemorrhage	15817013	1
-CONCLUSION: The rate of major hemorrhage was high in this old, frail group, but excluding fatalities, resulted in no long-term sequelae, and the stroke rate on warfarin was low, demonstrating how effective warfarin treatment is.	warfarin	stroke	15817013	-1
-CONCLUSION: The rate of major hemorrhage was high in this old, frail group, but excluding fatalities, resulted in no long-term sequelae, and the stroke rate on warfarin was low, demonstrating how effective warfarin treatment is.	warfarin	hemorrhage	15817013	1
-CONCLUSION: The rate of major hemorrhage was high in this old, frail group, but excluding fatalities, resulted in no long-term sequelae, and the stroke rate on warfarin was low, demonstrating how effective warfarin treatment is.	warfarin	stroke	15817013	-1
-Acute myocardial ischemic injury was induced in rats by subcutaneous injection of isoproterenol (85 mg/kg), for two consecutive days.	isoproterenol	myocardial ischemic injury	25080425	1
-Aspirin use increases the risk for serious bleeding events.	Aspirin	bleeding	19293073	-1
-The impact of immune-mediated heparin-induced thrombocytopenia type II (HIT type II) as a cause of thrombocytopenia after liver transplantation is not yet understood, with few literature citations reporting contradictory results.	heparin	HIT	24100055	1
-We conducted a population-based 45-day follow-up study of 232,390 people who were prescribed trimethoprim-sulfamethoxazole (TMP-SMZ), 266,951 prescribed trimethoprim alone, and 196,397 prescribed cephalexin, to estimate the risk of serious liver, blood, skin, and renal disorders resulting in referral or hospitalization associated with these drugs.	trimethoprim	renal disorders	7479194	-1
-We conducted a population-based 45-day follow-up study of 232,390 people who were prescribed trimethoprim-sulfamethoxazole (TMP-SMZ), 266,951 prescribed trimethoprim alone, and 196,397 prescribed cephalexin, to estimate the risk of serious liver, blood, skin, and renal disorders resulting in referral or hospitalization associated with these drugs.	cephalexin	renal disorders	7479194	-1
-We conducted a population-based 45-day follow-up study of 232,390 people who were prescribed trimethoprim-sulfamethoxazole (TMP-SMZ), 266,951 prescribed trimethoprim alone, and 196,397 prescribed cephalexin, to estimate the risk of serious liver, blood, skin, and renal disorders resulting in referral or hospitalization associated with these drugs.	trimethoprim-sulfamethoxazole	renal disorders	7479194	-1
-We conducted a population-based 45-day follow-up study of 232,390 people who were prescribed trimethoprim-sulfamethoxazole (TMP-SMZ), 266,951 prescribed trimethoprim alone, and 196,397 prescribed cephalexin, to estimate the risk of serious liver, blood, skin, and renal disorders resulting in referral or hospitalization associated with these drugs.	TMP-SMZ	renal disorders	7479194	-1
-P53 inhibition exacerbates late-stage anthracycline cardiotoxicity.	anthracycline	cardiotoxicity	24812279	-1
-AIMS: Doxorubicin (DOX) is an effective anti-cancer therapeutic, but is associated with both acute and late-stage cardiotoxicity.	Doxorubicin	cancer	24812279	-1
-AIMS: Doxorubicin (DOX) is an effective anti-cancer therapeutic, but is associated with both acute and late-stage cardiotoxicity.	Doxorubicin	cardiotoxicity	24812279	-1
-AIMS: Doxorubicin (DOX) is an effective anti-cancer therapeutic, but is associated with both acute and late-stage cardiotoxicity.	DOX	cancer	24812279	-1
-AIMS: Doxorubicin (DOX) is an effective anti-cancer therapeutic, but is associated with both acute and late-stage cardiotoxicity.	DOX	cardiotoxicity	24812279	-1
-A pilot study to assess the safety of dobutamine stress echocardiography in the emergency department evaluation of cocaine-associated chest pain.	dobutamine	chest pain	11423811	-1
-Cystic hyperplasia was associated with unopposed oestrogen therapy without progestagen.	progestagen	Cystic hyperplasia	89511	-1
-STUDY SELECTION: English-language randomized, controlled trials (RCTs); case-control studies; meta-analyses; and systematic reviews of aspirin versus control for the primary prevention of cardiovascular disease (CVD) were selected to answer the following questions: Does aspirin decrease coronary heart events, strokes, death from coronary heart events or stroke, or all-cause mortality in adults without known CVD?	aspirin	cardiovascular disease	19293073	-1
-STUDY SELECTION: English-language randomized, controlled trials (RCTs); case-control studies; meta-analyses; and systematic reviews of aspirin versus control for the primary prevention of cardiovascular disease (CVD) were selected to answer the following questions: Does aspirin decrease coronary heart events, strokes, death from coronary heart events or stroke, or all-cause mortality in adults without known CVD?	aspirin	CVD	19293073	-1
-STUDY SELECTION: English-language randomized, controlled trials (RCTs); case-control studies; meta-analyses; and systematic reviews of aspirin versus control for the primary prevention of cardiovascular disease (CVD) were selected to answer the following questions: Does aspirin decrease coronary heart events, strokes, death from coronary heart events or stroke, or all-cause mortality in adults without known CVD?	aspirin	CVD	19293073	-1
-STUDY SELECTION: English-language randomized, controlled trials (RCTs); case-control studies; meta-analyses; and systematic reviews of aspirin versus control for the primary prevention of cardiovascular disease (CVD) were selected to answer the following questions: Does aspirin decrease coronary heart events, strokes, death from coronary heart events or stroke, or all-cause mortality in adults without known CVD?	aspirin	death	19293073	-1
-STUDY SELECTION: English-language randomized, controlled trials (RCTs); case-control studies; meta-analyses; and systematic reviews of aspirin versus control for the primary prevention of cardiovascular disease (CVD) were selected to answer the following questions: Does aspirin decrease coronary heart events, strokes, death from coronary heart events or stroke, or all-cause mortality in adults without known CVD?	aspirin	strokes	19293073	1
-STUDY SELECTION: English-language randomized, controlled trials (RCTs); case-control studies; meta-analyses; and systematic reviews of aspirin versus control for the primary prevention of cardiovascular disease (CVD) were selected to answer the following questions: Does aspirin decrease coronary heart events, strokes, death from coronary heart events or stroke, or all-cause mortality in adults without known CVD?	aspirin	stroke	19293073	1
-STUDY SELECTION: English-language randomized, controlled trials (RCTs); case-control studies; meta-analyses; and systematic reviews of aspirin versus control for the primary prevention of cardiovascular disease (CVD) were selected to answer the following questions: Does aspirin decrease coronary heart events, strokes, death from coronary heart events or stroke, or all-cause mortality in adults without known CVD?	aspirin	cardiovascular disease	19293073	-1
-STUDY SELECTION: English-language randomized, controlled trials (RCTs); case-control studies; meta-analyses; and systematic reviews of aspirin versus control for the primary prevention of cardiovascular disease (CVD) were selected to answer the following questions: Does aspirin decrease coronary heart events, strokes, death from coronary heart events or stroke, or all-cause mortality in adults without known CVD?	aspirin	CVD	19293073	-1
-STUDY SELECTION: English-language randomized, controlled trials (RCTs); case-control studies; meta-analyses; and systematic reviews of aspirin versus control for the primary prevention of cardiovascular disease (CVD) were selected to answer the following questions: Does aspirin decrease coronary heart events, strokes, death from coronary heart events or stroke, or all-cause mortality in adults without known CVD?	aspirin	CVD	19293073	-1
-STUDY SELECTION: English-language randomized, controlled trials (RCTs); case-control studies; meta-analyses; and systematic reviews of aspirin versus control for the primary prevention of cardiovascular disease (CVD) were selected to answer the following questions: Does aspirin decrease coronary heart events, strokes, death from coronary heart events or stroke, or all-cause mortality in adults without known CVD?	aspirin	death	19293073	-1
-STUDY SELECTION: English-language randomized, controlled trials (RCTs); case-control studies; meta-analyses; and systematic reviews of aspirin versus control for the primary prevention of cardiovascular disease (CVD) were selected to answer the following questions: Does aspirin decrease coronary heart events, strokes, death from coronary heart events or stroke, or all-cause mortality in adults without known CVD?	aspirin	stroke	19293073	1
-Neuropsychiatric behaviors in the MPTP marmoset model of Parkinson's disease.	MPTP	Parkinson's disease	20169779	-1
-OBJECTIVE: Diazinon, a common organophosphate insecticide with genotoxic properties, was previously associated with lung cancer in the Agricultural Health Study (AHS) cohort, but few other epidemiological studies have examined diazinon-associated cancer risk.	Diazinon	cancer	25907210	-1
-OBJECTIVE: Diazinon, a common organophosphate insecticide with genotoxic properties, was previously associated with lung cancer in the Agricultural Health Study (AHS) cohort, but few other epidemiological studies have examined diazinon-associated cancer risk.	Diazinon	lung cancer	25907210	1
-OBJECTIVE: Diazinon, a common organophosphate insecticide with genotoxic properties, was previously associated with lung cancer in the Agricultural Health Study (AHS) cohort, but few other epidemiological studies have examined diazinon-associated cancer risk.	diazinon	cancer	25907210	-1
-OBJECTIVE: Diazinon, a common organophosphate insecticide with genotoxic properties, was previously associated with lung cancer in the Agricultural Health Study (AHS) cohort, but few other epidemiological studies have examined diazinon-associated cancer risk.	organophosphate	cancer	25907210	-1
-OBJECTIVE: Diazinon, a common organophosphate insecticide with genotoxic properties, was previously associated with lung cancer in the Agricultural Health Study (AHS) cohort, but few other epidemiological studies have examined diazinon-associated cancer risk.	organophosphate	lung cancer	25907210	-1
-CONCLUSION: In this preliminary study patients submitted to PTRA showed a lower susceptibility to renal damage induced by CM administration than PCI patients.	PTRA	renal damage	20192893	-1
-In this study population, combination therapies with VAL/HCTZ were associated with significantly greater BP reductions compared with either monotherapy, were well tolerated, and were associated with less hypokalemia than HCTZ alone.	HCTZ	hypokalemia	17379047	1
-In this study population, combination therapies with VAL/HCTZ were associated with significantly greater BP reductions compared with either monotherapy, were well tolerated, and were associated with less hypokalemia than HCTZ alone.	VAL	hypokalemia	17379047	-1
-By inhibiting the cytochrome P450 2D6, terbinafine had decreased metoprolol's clearance, leading in metoprolol accumulation which has resulted in clinically significant sinus bradycardia.	terbinafine	sinus bradycardia	24894748	-1
-By inhibiting the cytochrome P450 2D6, terbinafine had decreased metoprolol's clearance, leading in metoprolol accumulation which has resulted in clinically significant sinus bradycardia.	metoprolol's	sinus bradycardia	24894748	-1
-By inhibiting the cytochrome P450 2D6, terbinafine had decreased metoprolol's clearance, leading in metoprolol accumulation which has resulted in clinically significant sinus bradycardia.	metoprolol	sinus bradycardia	24894748	-1
-Temocapril did not attenuate proteinuria at 8 days, but it did markedly lower it from weeks 4 to 20.	Temocapril	proteinuria	11936424	-1
-The levodopa-treated MPTP-lesioned marmoset was used as a model of neuropsychiatric symptoms in PD patients.	MPTP	neuropsychiatric symptoms	20169779	-1
-The levodopa-treated MPTP-lesioned marmoset was used as a model of neuropsychiatric symptoms in PD patients.	MPTP	PD	20169779	-1
-The levodopa-treated MPTP-lesioned marmoset was used as a model of neuropsychiatric symptoms in PD patients.	levodopa	neuropsychiatric symptoms	20169779	-1
-The levodopa-treated MPTP-lesioned marmoset was used as a model of neuropsychiatric symptoms in PD patients.	levodopa	PD	20169779	-1
-OBJECTIVE: This study investigated the efficacy and tolerability of valsartan (VAL) or hydrochlorothiazide (HCTZ)-monotherapy and higher-dose combinations in patients with essential hypertension.	hydrochlorothiazide	hypertension	17379047	-1
-OBJECTIVE: This study investigated the efficacy and tolerability of valsartan (VAL) or hydrochlorothiazide (HCTZ)-monotherapy and higher-dose combinations in patients with essential hypertension.	HCTZ)-monotherapy	hypertension	17379047	-1
-OBJECTIVE: This study investigated the efficacy and tolerability of valsartan (VAL) or hydrochlorothiazide (HCTZ)-monotherapy and higher-dose combinations in patients with essential hypertension.	valsartan	hypertension	17379047	-1
-OBJECTIVE: This study investigated the efficacy and tolerability of valsartan (VAL) or hydrochlorothiazide (HCTZ)-monotherapy and higher-dose combinations in patients with essential hypertension.	VAL	hypertension	17379047	-1
-The glomerulosclerosis index (GSI) was 6.21 % at 4 weeks and respectively 25.35 % and 30.49 % at 14 and 20 weeks in the PAN group.	PAN	glomerulosclerosis	11936424	-1
-Administration of MK-801 30 or 60 min after pilocarpine, i.e., during status epilepticus, gradually reduced electrical and behavioral seizure activity and greatly enhanced the survival rate.	MK-801	status epilepticus	2553470	-1
-Administration of MK-801 30 or 60 min after pilocarpine, i.e., during status epilepticus, gradually reduced electrical and behavioral seizure activity and greatly enhanced the survival rate.	MK-801	seizure	2553470	-1
-Administration of MK-801 30 or 60 min after pilocarpine, i.e., during status epilepticus, gradually reduced electrical and behavioral seizure activity and greatly enhanced the survival rate.	pilocarpine	seizure	2553470	-1
-This dual effect of temsirolimus on tumor tissue could contribute to its recently reported efficiency in refractory MCL resistant to conventional chemotherapy.	temsirolimus	tumor	20828385	-1
-This dual effect of temsirolimus on tumor tissue could contribute to its recently reported efficiency in refractory MCL resistant to conventional chemotherapy.	temsirolimus	MCL	20828385	-1
-METHODS: Marmosets were administered 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (2.0 mg/kg s.c.) for five days, resulting in stable parkinsonism.	1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine	parkinsonism	20169779	-1
-The US FDA-recommended argatroban dose in HIT is 2 microg/kg/min (reduced in patients with hepatic impairment and in paediatric patients), adjusted to achieve activated partial thromboplastin times (aPTTs) 1.5-3 times baseline (not >100 seconds).	argatroban	HIT	19338378	-1
-The US FDA-recommended argatroban dose in HIT is 2 microg/kg/min (reduced in patients with hepatic impairment and in paediatric patients), adjusted to achieve activated partial thromboplastin times (aPTTs) 1.5-3 times baseline (not >100 seconds).	argatroban	hepatic impairment	19338378	-1
-The US FDA-recommended argatroban dose in HIT is 2 microg/kg/min (reduced in patients with hepatic impairment and in paediatric patients), adjusted to achieve activated partial thromboplastin times (aPTTs) 1.5-3 times baseline (not >100 seconds).	FDA	HIT	19338378	-1
-The US FDA-recommended argatroban dose in HIT is 2 microg/kg/min (reduced in patients with hepatic impairment and in paediatric patients), adjusted to achieve activated partial thromboplastin times (aPTTs) 1.5-3 times baseline (not >100 seconds).	FDA	hepatic impairment	19338378	-1
-We used Poisson regression to evaluate relations between two metrics of metolachlor use (lifetime days, intensity-weighted lifetime days) and cancer incidence.	metolachlor	cancer	26033014	-1
-Animals were evaluated for parkinsonian disability, dyskinesia and on-time (motor fluctuations) and neuropsychiatric-like behaviors on Day 0 (prior to levodopa) and on Days 1, 7, 13, 27 and 30 of treatment using post hoc DVD analysis by a trained rater, blind to the treatment day.	levodopa	parkinsonian disability	20169779	-1
-Animals were evaluated for parkinsonian disability, dyskinesia and on-time (motor fluctuations) and neuropsychiatric-like behaviors on Day 0 (prior to levodopa) and on Days 1, 7, 13, 27 and 30 of treatment using post hoc DVD analysis by a trained rater, blind to the treatment day.	levodopa	dyskinesia	20169779	1
-Reducing harm associated with anticoagulation: practical considerations of argatroban therapy in heparin-induced thrombocytopenia.	heparin	thrombocytopenia	19338378	-1
-Reducing harm associated with anticoagulation: practical considerations of argatroban therapy in heparin-induced thrombocytopenia.	argatroban	thrombocytopenia	19338378	-1
-The severity of pain due to etomidate injection, mean arterial pressure, heart rate, and adverse effects were also evaluated.	etomidate	pain	24535067	-1
-Argatroban is a hepatically metabolized, direct thrombin inhibitor used for prophylaxis or treatment of thrombosis in heparin-induced thrombocytopenia (HIT) and for patients with or at risk of HIT undergoing percutaneous coronary intervention (PCI).	heparin	thrombocytopenia	19338378	-1
-Argatroban is a hepatically metabolized, direct thrombin inhibitor used for prophylaxis or treatment of thrombosis in heparin-induced thrombocytopenia (HIT) and for patients with or at risk of HIT undergoing percutaneous coronary intervention (PCI).	heparin	HIT	19338378	-1
-Argatroban is a hepatically metabolized, direct thrombin inhibitor used for prophylaxis or treatment of thrombosis in heparin-induced thrombocytopenia (HIT) and for patients with or at risk of HIT undergoing percutaneous coronary intervention (PCI).	heparin	HIT	19338378	-1
-Argatroban is a hepatically metabolized, direct thrombin inhibitor used for prophylaxis or treatment of thrombosis in heparin-induced thrombocytopenia (HIT) and for patients with or at risk of HIT undergoing percutaneous coronary intervention (PCI).	heparin	thrombosis	19338378	-1
-Argatroban is a hepatically metabolized, direct thrombin inhibitor used for prophylaxis or treatment of thrombosis in heparin-induced thrombocytopenia (HIT) and for patients with or at risk of HIT undergoing percutaneous coronary intervention (PCI).	Argatroban	thrombocytopenia	19338378	-1
-Argatroban is a hepatically metabolized, direct thrombin inhibitor used for prophylaxis or treatment of thrombosis in heparin-induced thrombocytopenia (HIT) and for patients with or at risk of HIT undergoing percutaneous coronary intervention (PCI).	Argatroban	HIT	19338378	-1
-Argatroban is a hepatically metabolized, direct thrombin inhibitor used for prophylaxis or treatment of thrombosis in heparin-induced thrombocytopenia (HIT) and for patients with or at risk of HIT undergoing percutaneous coronary intervention (PCI).	Argatroban	HIT	19338378	-1
-Argatroban is a hepatically metabolized, direct thrombin inhibitor used for prophylaxis or treatment of thrombosis in heparin-induced thrombocytopenia (HIT) and for patients with or at risk of HIT undergoing percutaneous coronary intervention (PCI).	Argatroban	thrombosis	19338378	-1
-As anticipated, animals exhibited a progressive increase in levodopa-induced motor fluctuations, dyskinesia and wearing-off, that correlated with the duration of levodopa therapy.	levodopa	dyskinesia	20169779	1
-As anticipated, animals exhibited a progressive increase in levodopa-induced motor fluctuations, dyskinesia and wearing-off, that correlated with the duration of levodopa therapy.	levodopa	dyskinesia	20169779	1
-Carvedilol protects against doxorubicin-induced mitochondrial cardiomyopathy.	Carvedilol	cardiomyopathy	12498738	-1
-The objective of this review is to summarize practical considerations of argatroban therapy in HIT.	argatroban	HIT	19338378	-1
-Two cases of amisulpride overdose: a cause for prolonged QT syndrome.	amisulpride	overdose	15953230	-1
-In order to quantify the incidence of these cardiac events, we performed a meta-analysis of clinical trials comparing VNR with other chemotherapeutic agents in the treatment of various malignancies.	VNR	malignancies	14748761	-1
-Vasopressin plays a major role in the pathogenesis of DOCA-salt hypertension, since the elevation of blood pressure was not substantial in the rats with lithium-treated diabetes insipidus after DOCA-salt treatment.	Vasopressin	diabetes insipidus	6321816	-1
-Vasopressin plays a major role in the pathogenesis of DOCA-salt hypertension, since the elevation of blood pressure was not substantial in the rats with lithium-treated diabetes insipidus after DOCA-salt treatment.	Vasopressin	hypertension	6321816	-1
-Vasopressin plays a major role in the pathogenesis of DOCA-salt hypertension, since the elevation of blood pressure was not substantial in the rats with lithium-treated diabetes insipidus after DOCA-salt treatment.	lithium	diabetes insipidus	6321816	1
-Vasopressin plays a major role in the pathogenesis of DOCA-salt hypertension, since the elevation of blood pressure was not substantial in the rats with lithium-treated diabetes insipidus after DOCA-salt treatment.	lithium	hypertension	6321816	-1
-The present study aimed to explore the effect of MT induction on carmustine (BCNU)-induced hippocampal cognitive dysfunction in rats.	MT	hippocampal cognitive dysfunction	20046642	-1
-The present study aimed to explore the effect of MT induction on carmustine (BCNU)-induced hippocampal cognitive dysfunction in rats.	BCNU)-induced	hippocampal cognitive dysfunction	20046642	1
-In addition to experiencing hypercalcemic episodes with peak calcium values of 2.7 to 3.8 mmol/L (10.7 to 15.0 mg/dL), patients in the hypercalcemic group exhibited a significant increase in the mean calcium concentration obtained during 6 months before the switch, compared with the mean value obtained during the 7 months of observation after the switch (2.4 +/-	calcium	hypercalcemic episodes	2239937	-1
-In addition to experiencing hypercalcemic episodes with peak calcium values of 2.7 to 3.8 mmol/L (10.7 to 15.0 mg/dL), patients in the hypercalcemic group exhibited a significant increase in the mean calcium concentration obtained during 6 months before the switch, compared with the mean value obtained during the 7 months of observation after the switch (2.4 +/-	calcium	hypercalcemic episodes	2239937	-1
-Early paracentral visual field loss in patients taking hydroxychloroquine.	hydroxychloroquine	paracentral visual field loss	17159032	1
-Several cytopathic mechanisms have been suggested to mediate the dose-limiting cumulative and irreversible cardiomyopathy caused by doxorubicin.	doxorubicin	cardiomyopathy	12498738	1
-MK-801 augments pilocarpine-induced electrographic seizure but protects against brain damage in rats.	MK-801	seizure	9061777	1
-MK-801 augments pilocarpine-induced electrographic seizure but protects against brain damage in rats.	MK-801	brain damage	9061777	-1
-MK-801 augments pilocarpine-induced electrographic seizure but protects against brain damage in rats.	pilocarpine	brain damage	9061777	-1
-Smoking of crack cocaine as a risk factor for HIV infection among people who use injection drugs.	crack cocaine	HIV infection	19841052	-1
-Adrenaline-induced hypertension was used to destroy the BBB, which was evaluated using triphenyltetrazolium (TTC) staining of the brain slices just after giving adrenaline for 30 s.	triphenyltetrazolium	hypertension	12487093	-1
-Adrenaline-induced hypertension was used to destroy the BBB, which was evaluated using triphenyltetrazolium (TTC) staining of the brain slices just after giving adrenaline for 30 s.	TTC	hypertension	12487093	-1
-RESULTS: Anxiety was documented in both groups of PDN treated rats compared with controls.	PDN	Anxiety	11708428	1
-This suggests that bromocriptine should be further evaluated as potential therapy for neuroleptic-associated hyperprolactinemia and amenorrhea/galactorrhea.	bromocriptine	hyperprolactinemia	1359137	-1
-This suggests that bromocriptine should be further evaluated as potential therapy for neuroleptic-associated hyperprolactinemia and amenorrhea/galactorrhea.	bromocriptine	amenorrhea/galactorrhea	1359137	-1
-Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment.	testosterone	impaired the memory	24902786	-1
-Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment.	testosterone	memory impairment	24902786	-1
-Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment.	tamoxifen	impaired the memory	24902786	1
-Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment.	STZ-	impaired the memory	24902786	1
-Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment.	STZ-	memory impairment	24902786	1
-Although the oral administration of class IC drugs, including pilsicainide, is effective to terminate atrial fibrillation, careful consideration must be taken before giving these drugs to octogenarians.	pilsicainide	atrial fibrillation	24653743	-1
-Coronary vasospasm may be induced by the non-selective beta-blocking properties of sotalol.	sotalol	Coronary vasospasm	15609701	1
-An experimental model of focal segmental glomerular sclerosis (FSGS) was developed in rats by the combined administration of puromycin-aminonucleoside (AMNS) and protamine sulfate (PS).	puromycin-aminonucleoside	glomerular sclerosis	3323599	-1
-An experimental model of focal segmental glomerular sclerosis (FSGS) was developed in rats by the combined administration of puromycin-aminonucleoside (AMNS) and protamine sulfate (PS).	AMNS	glomerular sclerosis	3323599	-1
-An experimental model of focal segmental glomerular sclerosis (FSGS) was developed in rats by the combined administration of puromycin-aminonucleoside (AMNS) and protamine sulfate (PS).	protamine sulfate	glomerular sclerosis	3323599	-1
-An experimental model of focal segmental glomerular sclerosis (FSGS) was developed in rats by the combined administration of puromycin-aminonucleoside (AMNS) and protamine sulfate (PS).	PS	glomerular sclerosis	3323599	-1
-BACKGROUND: Renal dysfunction induced by iodinated contrast medium (CM) administration can minimize the benefit of the interventional procedure in patients undergoing renal angioplasty (PTRA).	PTRA	CM	20192893	-1
-BACKGROUND: Renal dysfunction induced by iodinated contrast medium (CM) administration can minimize the benefit of the interventional procedure in patients undergoing renal angioplasty (PTRA).	PTRA	Renal dysfunction	20192893	-1
-Disruption of hepatic lipid homeostasis in mice after amiodarone treatment is associated with peroxisome proliferator-activated receptor-alpha target gene activation.	amiodarone	hepatic lipid homeostasis	15265979	1
-5-Fluorouracil cardiotoxicity induced by alpha-fluoro-beta-alanine.	5-Fluorouracil	cardiotoxicity	16369751	-1
-5-Fluorouracil cardiotoxicity induced by alpha-fluoro-beta-alanine.	alpha-fluoro-beta-alanine	cardiotoxicity	16369751	-1
-However, DA response was lost if a 9-month long haloperidol-induced hyperprolactinemia was followed by a 1 1/2 month-long extremely high increase in serum PRL levels produced by implantation of MMQ cells under the kidney capsule.	DA	hyperprolactinemia	9128918	-1
-However, DA response was lost if a 9-month long haloperidol-induced hyperprolactinemia was followed by a 1 1/2 month-long extremely high increase in serum PRL levels produced by implantation of MMQ cells under the kidney capsule.	haloperidol	hyperprolactinemia	9128918	1
-Amiodarone, an efficacious and widely used antiarrhythmic agent, has been reported to cause hepatotoxicity in some patients.	Amiodarone	hepatotoxicity	15265979	1
-Cardiotoxicity is a rare complication occurring during 5-fluorouracil (5-FU) treatment for malignancies.	5-fluorouracil	malignancies	16369751	-1
-Cardiotoxicity is a rare complication occurring during 5-fluorouracil (5-FU) treatment for malignancies.	5-fluorouracil	Cardiotoxicity	16369751	-1
-Cardiotoxicity is a rare complication occurring during 5-fluorouracil (5-FU) treatment for malignancies.	5-FU	malignancies	16369751	-1
-Cardiotoxicity is a rare complication occurring during 5-fluorouracil (5-FU) treatment for malignancies.	5-FU	Cardiotoxicity	16369751	-1
-The objective of this investigation was to test the hypothesis that carvedilol, a nonselective beta-adrenergic receptor antagonist with potent antioxidant properties, protects against the cardiac and hepatic mitochondrial bioenergetic dysfunction associated with subchronic doxorubicin toxicity.	doxorubicin	toxicity	12498738	-1
-The objective of this investigation was to test the hypothesis that carvedilol, a nonselective beta-adrenergic receptor antagonist with potent antioxidant properties, protects against the cardiac and hepatic mitochondrial bioenergetic dysfunction associated with subchronic doxorubicin toxicity.	doxorubicin	hepatic mitochondrial bioenergetic dysfunction	12498738	-1
-The objective of this investigation was to test the hypothesis that carvedilol, a nonselective beta-adrenergic receptor antagonist with potent antioxidant properties, protects against the cardiac and hepatic mitochondrial bioenergetic dysfunction associated with subchronic doxorubicin toxicity.	carvedilol	toxicity	12498738	-1
-The objective of this investigation was to test the hypothesis that carvedilol, a nonselective beta-adrenergic receptor antagonist with potent antioxidant properties, protects against the cardiac and hepatic mitochondrial bioenergetic dysfunction associated with subchronic doxorubicin toxicity.	carvedilol	hepatic mitochondrial bioenergetic dysfunction	12498738	-1
-Does aspirin increase gastrointestinal bleeding or hemorrhagic strokes?	aspirin	hemorrhagic strokes	19293073	1
-Pre-treatment of bupivacaine-induced cardiovascular depression using different lipid formulations of propofol.	propofol	cardiovascular depression	24438483	-1
-Pre-treatment of bupivacaine-induced cardiovascular depression using different lipid formulations of propofol.	bupivacaine	cardiovascular depression	24438483	-1
-We used updated diazinon exposure and cancer incidence information to evaluate solid tumour risk in the AHS.	diazinon	cancer	25907210	-1
-We used updated diazinon exposure and cancer incidence information to evaluate solid tumour risk in the AHS.	diazinon	tumour	25907210	-1
-We report a case of acute renal failure after HD-MTX therapy in a patient with ileostomy, The patient was a 3-year-old boy who had received a living-related liver transplantation for congenital biliary atresia.	MTX	HD	20009434	-1
-We report a case of acute renal failure after HD-MTX therapy in a patient with ileostomy, The patient was a 3-year-old boy who had received a living-related liver transplantation for congenital biliary atresia.	MTX	acute renal failure	20009434	-1
-We report a case of acute renal failure after HD-MTX therapy in a patient with ileostomy, The patient was a 3-year-old boy who had received a living-related liver transplantation for congenital biliary atresia.	MTX	congenital biliary atresia	20009434	-1
-Toxicity of CAA was determined by protein content, cell number, LDH release, trypan blue exclusion assay and caspase-3 activity.	CAA	Toxicity	17035713	-1
-DESIGN: A prospective study to monitor indinavir-related nephrotoxicity in a cohort of 30 human immunodeficiency virus type 1-infected children treated with indinavir.	indinavir	human immunodeficiency	12165618	-1
-DESIGN: A prospective study to monitor indinavir-related nephrotoxicity in a cohort of 30 human immunodeficiency virus type 1-infected children treated with indinavir.	indinavir	nephrotoxicity	12165618	1
-DESIGN: A prospective study to monitor indinavir-related nephrotoxicity in a cohort of 30 human immunodeficiency virus type 1-infected children treated with indinavir.	indinavir	human immunodeficiency	12165618	-1
-Tacrolimus-related seizure after pediatric liver transplantation--a single-center experience.	Tacrolimus	seizure	24283660	1
-In addition to methadone dose, 15 demographic, biological, and pharmacological variables were considered as potential risk factors for QT prolongation.	methadone	QT prolongation	16801510	1
-CAA reduced hRPTEC cell number and protein, induced a loss in free intracellular thiols and an increase in necrosis markers.	CAA	necrosis	17035713	-1
-CAA reduced hRPTEC cell number and protein, induced a loss in free intracellular thiols and an increase in necrosis markers.	thiols	necrosis	17035713	-1
-RESULTS: The hyperventilation maneuver caused a decrease in spontaneous ventilation in pilocarpine-treated and control rats.	pilocarpine	hyperventilation maneuver	12752472	-1
-Possible pathophysiological mechanisms which may have been operative in this case include: a direct central nervous system (CNS) toxic effect of valproic acid; a paradoxical epileptogenic effect secondary to the drug; and an indirect CNS toxic effect mediated through valproic acid-induced hyperammonemia.	valproic acid	hyperammonemia	3084231	1
-Possible pathophysiological mechanisms which may have been operative in this case include: a direct central nervous system (CNS) toxic effect of valproic acid; a paradoxical epileptogenic effect secondary to the drug; and an indirect CNS toxic effect mediated through valproic acid-induced hyperammonemia.	valproic acid	hyperammonemia	3084231	1
-Six patients (3.6%) in the methadone group presented torsades de pointes.	methadone	torsades de pointes	16801510	-1
-Using mice derived from a classical F2 and backcross genetic design, a relationship between nicotine-induced seizures and alpha-bungarotoxin nicotinic receptor concentration was found.	nicotine	seizures	4010471	1
-Using mice derived from a classical F2 and backcross genetic design, a relationship between nicotine-induced seizures and alpha-bungarotoxin nicotinic receptor concentration was found.	alpha-bungarotoxin	seizures	4010471	-1
-contrast material to enable diagnosis of ureteric stones or obstruction in patients with HIV infection who receive indinavir therapy.	indinavir	HIV infection	9725303	-1
-contrast material to enable diagnosis of ureteric stones or obstruction in patients with HIV infection who receive indinavir therapy.	indinavir	ureteric stones or obstruction	9725303	-1
-Immunoprecipitation/Western blotting showed that Smad3 was activated by AGEs but was inhibited by SIS3 in MMECs and in STZ-induced diabetic nephropathy.	STZ	diabetic nephropathy	20682692	1
-Multivariate regression analysis allowed attribution of 31.8% of QTc variability to methadone dose, cytochrome P-450 3A4 drug-drug interactions, hypokalemia, and altered liver function.	methadone	hypokalemia	16801510	-1
-Acidification, which slowed the reaction of CAA with thiol donors, could also attenuate effects of CAA on necrosis markers, thiol depletion and cysteine protease inhibition in living cells.	CAA	necrosis	17035713	-1
-Acidification, which slowed the reaction of CAA with thiol donors, could also attenuate effects of CAA on necrosis markers, thiol depletion and cysteine protease inhibition in living cells.	CAA	necrosis	17035713	-1
-Acidification, which slowed the reaction of CAA with thiol donors, could also attenuate effects of CAA on necrosis markers, thiol depletion and cysteine protease inhibition in living cells.	thiol	necrosis	17035713	-1
-Acidification, which slowed the reaction of CAA with thiol donors, could also attenuate effects of CAA on necrosis markers, thiol depletion and cysteine protease inhibition in living cells.	thiol	necrosis	17035713	-1
-Neuroprotective effects of melatonin upon the offspring cerebellar cortex in the rat model of BCNU-induced cortical dysplasia.	melatonin	cortical dysplasia	17572393	-1
-Thus, CAA directly reacts with cellular protein and non-protein thiols, mediating its toxicity on hRPTEC.	CAA	toxicity	17035713	-1
-Thus, CAA directly reacts with cellular protein and non-protein thiols, mediating its toxicity on hRPTEC.	thiols	toxicity	17035713	-1
-Therefore, urinary acidification could be an option to prevent IFO nephropathy in patients.	IFO	nephropathy	17035713	1
-Four (5%) patients had from torsades de pointes during the initial oral treatment with d,l-sotalol.	l-sotalol	torsades de pointes	9125676	1
-A 33-year-old man presented with rhabdomyolysis and cerebral ischemic stroke after intravenous heroin.	heroin	cerebral ischemic stroke	19392810	-1
-Ethambutol and optic neuropathy.	Ethambutol	optic neuropathy	12948256	1
-We describe a 47-year-old woman with an acute myocardial infarction after administration of sumatriptan 6 mg subcutaneously for cluster headache.	sumatriptan	myocardial infarction	8096565	1
-We describe a 47-year-old woman with an acute myocardial infarction after administration of sumatriptan 6 mg subcutaneously for cluster headache.	sumatriptan	cluster headache	8096565	-1
-PURPOSE: To demonstrate the association between ethambutol and optic neuropathy.	ethambutol	optic neuropathy	12948256	1
-An electrical seizure measured with hippocampal EEG appeared in the pilocarpine-treated group.	pilocarpine	seizure	9061777	1
-It was reported that there was a case of severe malaria patient with jaundice who presented with arrhythmia (premature ventricular contraction) while getting quinine infusion was reported.	quinine	arrhythmia	17297207	-1
-It was reported that there was a case of severe malaria patient with jaundice who presented with arrhythmia (premature ventricular contraction) while getting quinine infusion was reported.	quinine	malaria	17297207	-1
-It was reported that there was a case of severe malaria patient with jaundice who presented with arrhythmia (premature ventricular contraction) while getting quinine infusion was reported.	quinine	jaundice	17297207	-1
-METHOD: Thirteen patients who developed optic neuropathy after being treated with ethambutol for tuberculosis of the lung or lymph node at Siriraj Hospital between 1997 and 2001 were retrospectively reviewed.	ethambutol	optic neuropathy	12948256	1
-METHOD: Thirteen patients who developed optic neuropathy after being treated with ethambutol for tuberculosis of the lung or lymph node at Siriraj Hospital between 1997 and 2001 were retrospectively reviewed.	ethambutol	tuberculosis	12948256	-1
-Ethambutol is known to cause optic neuropathy and, more rarely, axonal polyneuropathy.	Ethambutol	optic neuropathy	24897009	1
-Ethambutol is known to cause optic neuropathy and, more rarely, axonal polyneuropathy.	Ethambutol	axonal polyneuropathy	24897009	1
-Overall, the altered cardiac contractility and excitability characteristics, the myocardial metabolic disturbances, and the hypersensitivity of the cardiovascular system to sodium pentobarbital suggest the existence of a heretofore undescribed cardiomyopathic disorder induced by chronic barium exposure.	sodium pentobarbital	myocardial metabolic disturbances	3975902	-1
-Overall, the altered cardiac contractility and excitability characteristics, the myocardial metabolic disturbances, and the hypersensitivity of the cardiovascular system to sodium pentobarbital suggest the existence of a heretofore undescribed cardiomyopathic disorder induced by chronic barium exposure.	sodium pentobarbital	cardiomyopathic disorder	3975902	-1
-Overall, the altered cardiac contractility and excitability characteristics, the myocardial metabolic disturbances, and the hypersensitivity of the cardiovascular system to sodium pentobarbital suggest the existence of a heretofore undescribed cardiomyopathic disorder induced by chronic barium exposure.	sodium pentobarbital	hypersensitivity	3975902	-1
-Overall, the altered cardiac contractility and excitability characteristics, the myocardial metabolic disturbances, and the hypersensitivity of the cardiovascular system to sodium pentobarbital suggest the existence of a heretofore undescribed cardiomyopathic disorder induced by chronic barium exposure.	barium	myocardial metabolic disturbances	3975902	-1
-Overall, the altered cardiac contractility and excitability characteristics, the myocardial metabolic disturbances, and the hypersensitivity of the cardiovascular system to sodium pentobarbital suggest the existence of a heretofore undescribed cardiomyopathic disorder induced by chronic barium exposure.	barium	cardiomyopathic disorder	3975902	-1
-Overall, the altered cardiac contractility and excitability characteristics, the myocardial metabolic disturbances, and the hypersensitivity of the cardiovascular system to sodium pentobarbital suggest the existence of a heretofore undescribed cardiomyopathic disorder induced by chronic barium exposure.	barium	hypersensitivity	3975902	-1
-In the third patient, the MPO-ANCA titre increased to 204 U/ml and she developed a higher fever, oral ulcers and polyarthralgia, but the symptoms resolved 2 weeks after stopping PTU therapy, and the MPO-ANCA titre decreased to 20.7 U/ml by 4 months after discontinuing PTU.	PTU	fever	11380496	1
-In the third patient, the MPO-ANCA titre increased to 204 U/ml and she developed a higher fever, oral ulcers and polyarthralgia, but the symptoms resolved 2 weeks after stopping PTU therapy, and the MPO-ANCA titre decreased to 20.7 U/ml by 4 months after discontinuing PTU.	PTU	polyarthralgia	11380496	1
-In the third patient, the MPO-ANCA titre increased to 204 U/ml and she developed a higher fever, oral ulcers and polyarthralgia, but the symptoms resolved 2 weeks after stopping PTU therapy, and the MPO-ANCA titre decreased to 20.7 U/ml by 4 months after discontinuing PTU.	PTU	ulcers	11380496	-1
-In the third patient, the MPO-ANCA titre increased to 204 U/ml and she developed a higher fever, oral ulcers and polyarthralgia, but the symptoms resolved 2 weeks after stopping PTU therapy, and the MPO-ANCA titre decreased to 20.7 U/ml by 4 months after discontinuing PTU.	PTU	fever	11380496	1
-In the third patient, the MPO-ANCA titre increased to 204 U/ml and she developed a higher fever, oral ulcers and polyarthralgia, but the symptoms resolved 2 weeks after stopping PTU therapy, and the MPO-ANCA titre decreased to 20.7 U/ml by 4 months after discontinuing PTU.	PTU	ulcers	11380496	-1
-was observed in a 57-year-old woman, under treatment for angina with 80 mg propranolol daily.	propranolol	angina	6529939	-1
-RESULTS: All patients had optic neuropathy between 1 to 6 months (mean = 2.9 months) after starting ethambutol therapy at a dosage ranging from 13 to 20 mg/kg/day (mean = 17 mg/kg/day).	ethambutol	optic neuropathy	12948256	1
-We characterize the clinical, neurophysiological, and neuroimaging findings in a 72-year-old man who developed visual loss and paresthesias after 11 weeks of exposure to a supratherapeutic dose of ethambutol.	ethambutol	visual loss	24897009	1
-Amphotericin B concentrations in the kidney in NS-718-treated rats were higher than those in D-AmB-treated rats.	Amphotericin B	NS-718-treated	10933650	-1
-Amphotericin B concentrations in the kidney in NS-718-treated rats were higher than those in D-AmB-treated rats.	D-AmB	NS-718-treated	10933650	-1
-Subsequent HD-MTX therapy caused acute renal failure that required continuous hemodialysis.	MTX	HD	20009434	-1
-Subsequent HD-MTX therapy caused acute renal failure that required continuous hemodialysis.	MTX	acute renal failure	20009434	-1
-This study was designed to evaluate the alterations in offspring rat cerebellum induced by maternal exposure to carmustine-[1,3-bis (2-chloroethyl)-1-nitrosoure] (BCNU) and to investigate the effects of exogenous melatonin upon cerebellar BCNU-induced cortical dysplasia, using histological and biochemical analyses.	melatonin	cortical dysplasia	17572393	-1
-This study was designed to evaluate the alterations in offspring rat cerebellum induced by maternal exposure to carmustine-[1,3-bis (2-chloroethyl)-1-nitrosoure] (BCNU) and to investigate the effects of exogenous melatonin upon cerebellar BCNU-induced cortical dysplasia, using histological and biochemical analyses.	BCNU	cortical dysplasia	17572393	1
-This study was designed to evaluate the alterations in offspring rat cerebellum induced by maternal exposure to carmustine-[1,3-bis (2-chloroethyl)-1-nitrosoure] (BCNU) and to investigate the effects of exogenous melatonin upon cerebellar BCNU-induced cortical dysplasia, using histological and biochemical analyses.	BCNU	cortical dysplasia	17572393	1
-The authors induced myodystrophy in the rat by giving it a diet lacking in vitamin E. The pharmacological characteristics of vitamin E and the degenerative changes brought about by its deficiency, especially in the muscles, are illustrated.	vitamin E	myodystrophy	753803	1
-We conclude that previously reported hypoglycemia, hyperbilirubinemia, polycythemia, neonatal apnea, and bradycardia are not invariable and cannot be statistically correlated with chronic propranolol therapy.	propranolol	bradycardia	573555	-1
-We conclude that previously reported hypoglycemia, hyperbilirubinemia, polycythemia, neonatal apnea, and bradycardia are not invariable and cannot be statistically correlated with chronic propranolol therapy.	propranolol	polycythemia	573555	-1
-We conclude that previously reported hypoglycemia, hyperbilirubinemia, polycythemia, neonatal apnea, and bradycardia are not invariable and cannot be statistically correlated with chronic propranolol therapy.	propranolol	hypoglycemia	573555	-1
-We conclude that previously reported hypoglycemia, hyperbilirubinemia, polycythemia, neonatal apnea, and bradycardia are not invariable and cannot be statistically correlated with chronic propranolol therapy.	propranolol	apnea	573555	-1
-We conclude that previously reported hypoglycemia, hyperbilirubinemia, polycythemia, neonatal apnea, and bradycardia are not invariable and cannot be statistically correlated with chronic propranolol therapy.	propranolol	hyperbilirubinemia	573555	-1
-Scopolamine and pentobarbital blocked the pilocarpine-induced electrographic seizure, MK-801 treatment augmented the electrographic seizure induced by pilocarpine.	pentobarbital	seizure	9061777	-1
-Scopolamine and pentobarbital blocked the pilocarpine-induced electrographic seizure, MK-801 treatment augmented the electrographic seizure induced by pilocarpine.	pentobarbital	seizure	9061777	-1
-Scopolamine and pentobarbital blocked the pilocarpine-induced electrographic seizure, MK-801 treatment augmented the electrographic seizure induced by pilocarpine.	pilocarpine	seizure	9061777	1
-Scopolamine and pentobarbital blocked the pilocarpine-induced electrographic seizure, MK-801 treatment augmented the electrographic seizure induced by pilocarpine.	pilocarpine	seizure	9061777	1
-Scopolamine and pentobarbital blocked the pilocarpine-induced electrographic seizure, MK-801 treatment augmented the electrographic seizure induced by pilocarpine.	pilocarpine	seizure	9061777	1
-Scopolamine and pentobarbital blocked the pilocarpine-induced electrographic seizure, MK-801 treatment augmented the electrographic seizure induced by pilocarpine.	pilocarpine	seizure	9061777	1
-Scopolamine and pentobarbital blocked the pilocarpine-induced electrographic seizure, MK-801 treatment augmented the electrographic seizure induced by pilocarpine.	Scopolamine	seizure	9061777	-1
-Scopolamine and pentobarbital blocked the pilocarpine-induced electrographic seizure, MK-801 treatment augmented the electrographic seizure induced by pilocarpine.	Scopolamine	seizure	9061777	-1
-Five phenotypic characteristics--locomotor activity, righting ability, clonic seizure induction, stress-induced lethality, death without external stress--were scored at various caffeine doses in drug-naive animals under empirically optimized, rigidly constant experimental conditions.	caffeine	death	6728873	-1
-To quantify this population, the total number of ectopic hilar granule cells was estimated using unbiased stereology at different times after pilocarpine-induced status epilepticus.	pilocarpine	status epilepticus	17042797	1
-Aza patients had significantly more staphylococcal infections than all other transplant groups (P less than 0.005), and systemic fungal infections occurred only in the liver transplant group.	Aza	systemic fungal infections	6310832	-1
-Aza patients had significantly more staphylococcal infections than all other transplant groups (P less than 0.005), and systemic fungal infections occurred only in the liver transplant group.	Aza	staphylococcal infections	6310832	-1
-Paclitaxel and 5-fluorouracil have additive cytotoxicity in MCF-7 cell lines.	Paclitaxel	cytotoxicity	9071336	-1
-Paclitaxel and 5-fluorouracil have additive cytotoxicity in MCF-7 cell lines.	5-fluorouracil	cytotoxicity	9071336	-1
-Our in vitro and in vivo results suggest that incorporation of amphotericin B into lipid nanospheres of NS-718 attenuates the nephrotoxicity of amphotericin B.	amphotericin B	NS-718	10933650	-1
-Our in vitro and in vivo results suggest that incorporation of amphotericin B into lipid nanospheres of NS-718 attenuates the nephrotoxicity of amphotericin B.	amphotericin B	nephrotoxicity	10933650	-1
-Our in vitro and in vivo results suggest that incorporation of amphotericin B into lipid nanospheres of NS-718 attenuates the nephrotoxicity of amphotericin B.	amphotericin	NS-718	10933650	-1
-Our in vitro and in vivo results suggest that incorporation of amphotericin B into lipid nanospheres of NS-718 attenuates the nephrotoxicity of amphotericin B.	amphotericin	nephrotoxicity	10933650	-1
-In general, the dihydropyridine calcium channel blockers are usually well tolerated, with headache, facial flushing, palpitations, edema, nausea, anorexia, and dizziness being the more common adverse effects.	dihydropyridine	nausea	3323259	-1
-In general, the dihydropyridine calcium channel blockers are usually well tolerated, with headache, facial flushing, palpitations, edema, nausea, anorexia, and dizziness being the more common adverse effects.	dihydropyridine	anorexia	3323259	-1
-In general, the dihydropyridine calcium channel blockers are usually well tolerated, with headache, facial flushing, palpitations, edema, nausea, anorexia, and dizziness being the more common adverse effects.	dihydropyridine	headache	3323259	-1
-In general, the dihydropyridine calcium channel blockers are usually well tolerated, with headache, facial flushing, palpitations, edema, nausea, anorexia, and dizziness being the more common adverse effects.	dihydropyridine	edema	3323259	-1
-In general, the dihydropyridine calcium channel blockers are usually well tolerated, with headache, facial flushing, palpitations, edema, nausea, anorexia, and dizziness being the more common adverse effects.	dihydropyridine	facial flushing	3323259	-1
-In general, the dihydropyridine calcium channel blockers are usually well tolerated, with headache, facial flushing, palpitations, edema, nausea, anorexia, and dizziness being the more common adverse effects.	dihydropyridine	dizziness	3323259	-1
-In general, the dihydropyridine calcium channel blockers are usually well tolerated, with headache, facial flushing, palpitations, edema, nausea, anorexia, and dizziness being the more common adverse effects.	calcium	nausea	3323259	-1
-In general, the dihydropyridine calcium channel blockers are usually well tolerated, with headache, facial flushing, palpitations, edema, nausea, anorexia, and dizziness being the more common adverse effects.	calcium	anorexia	3323259	-1
-In general, the dihydropyridine calcium channel blockers are usually well tolerated, with headache, facial flushing, palpitations, edema, nausea, anorexia, and dizziness being the more common adverse effects.	calcium	headache	3323259	-1
-In general, the dihydropyridine calcium channel blockers are usually well tolerated, with headache, facial flushing, palpitations, edema, nausea, anorexia, and dizziness being the more common adverse effects.	calcium	edema	3323259	-1
-In general, the dihydropyridine calcium channel blockers are usually well tolerated, with headache, facial flushing, palpitations, edema, nausea, anorexia, and dizziness being the more common adverse effects.	calcium	facial flushing	3323259	-1
-In general, the dihydropyridine calcium channel blockers are usually well tolerated, with headache, facial flushing, palpitations, edema, nausea, anorexia, and dizziness being the more common adverse effects.	calcium	dizziness	3323259	-1
-Thereafter, seizures were induced by pilocarpine injections in trained and non-trained control groups.	pilocarpine	seizures	16876986	1
-Chemokine CCL2 and its receptor CCR2 are increased in the hippocampus following pilocarpine-induced status epilepticus.	Chemokine CCL2	status epilepticus	20034406	-1
-Chemokine CCL2 and its receptor CCR2 are increased in the hippocampus following pilocarpine-induced status epilepticus.	pilocarpine	status epilepticus	20034406	1
-Loss of endothelial cell-derived nitric oxide (NO) in hypertension is a hallmark of arterial dysfunction.	nitric oxide	arterial dysfunction	16810074	-1
-Loss of endothelial cell-derived nitric oxide (NO) in hypertension is a hallmark of arterial dysfunction.	NO	hypertension	16810074	1
-Loss of endothelial cell-derived nitric oxide (NO) in hypertension is a hallmark of arterial dysfunction.	NO	arterial dysfunction	16810074	-1
-The risk of clinically important idiopathic liver disease was similar for persons prescribed TMP-SMZ (5.2/100,000) and those prescribed trimethoprim alone (3.8/100,000).	trimethoprim	idiopathic liver disease	7479194	1
-There was no change in the levels of DA, norepinephrine (NE), serotonin (5-HT), or their metabolites in the arcuate nucleus (AN), medial preoptic area (MPA), caudate putamen (CP), substantia nigra (SN), and zona incerta (ZI), except for a decrease in 5-hydroxyindoleacetic acid (5-HIAA) in the AN after 6-months of hyperprolactinemia and an increase in DA concentrations in the AN after 9-months of hyperprolactinemia.	5-hydroxyindoleacetic acid	hyperprolactinemia	9128918	-1
-There was no change in the levels of DA, norepinephrine (NE), serotonin (5-HT), or their metabolites in the arcuate nucleus (AN), medial preoptic area (MPA), caudate putamen (CP), substantia nigra (SN), and zona incerta (ZI), except for a decrease in 5-hydroxyindoleacetic acid (5-HIAA) in the AN after 6-months of hyperprolactinemia and an increase in DA concentrations in the AN after 9-months of hyperprolactinemia.	5-hydroxyindoleacetic acid	hyperprolactinemia	9128918	-1
-There was no change in the levels of DA, norepinephrine (NE), serotonin (5-HT), or their metabolites in the arcuate nucleus (AN), medial preoptic area (MPA), caudate putamen (CP), substantia nigra (SN), and zona incerta (ZI), except for a decrease in 5-hydroxyindoleacetic acid (5-HIAA) in the AN after 6-months of hyperprolactinemia and an increase in DA concentrations in the AN after 9-months of hyperprolactinemia.	5-HIAA	hyperprolactinemia	9128918	-1
-There was no change in the levels of DA, norepinephrine (NE), serotonin (5-HT), or their metabolites in the arcuate nucleus (AN), medial preoptic area (MPA), caudate putamen (CP), substantia nigra (SN), and zona incerta (ZI), except for a decrease in 5-hydroxyindoleacetic acid (5-HIAA) in the AN after 6-months of hyperprolactinemia and an increase in DA concentrations in the AN after 9-months of hyperprolactinemia.	5-HIAA	hyperprolactinemia	9128918	-1
-There was no change in the levels of DA, norepinephrine (NE), serotonin (5-HT), or their metabolites in the arcuate nucleus (AN), medial preoptic area (MPA), caudate putamen (CP), substantia nigra (SN), and zona incerta (ZI), except for a decrease in 5-hydroxyindoleacetic acid (5-HIAA) in the AN after 6-months of hyperprolactinemia and an increase in DA concentrations in the AN after 9-months of hyperprolactinemia.	DA	hyperprolactinemia	9128918	-1
-There was no change in the levels of DA, norepinephrine (NE), serotonin (5-HT), or their metabolites in the arcuate nucleus (AN), medial preoptic area (MPA), caudate putamen (CP), substantia nigra (SN), and zona incerta (ZI), except for a decrease in 5-hydroxyindoleacetic acid (5-HIAA) in the AN after 6-months of hyperprolactinemia and an increase in DA concentrations in the AN after 9-months of hyperprolactinemia.	DA	hyperprolactinemia	9128918	-1
-There was no change in the levels of DA, norepinephrine (NE), serotonin (5-HT), or their metabolites in the arcuate nucleus (AN), medial preoptic area (MPA), caudate putamen (CP), substantia nigra (SN), and zona incerta (ZI), except for a decrease in 5-hydroxyindoleacetic acid (5-HIAA) in the AN after 6-months of hyperprolactinemia and an increase in DA concentrations in the AN after 9-months of hyperprolactinemia.	DA	hyperprolactinemia	9128918	-1
-There was no change in the levels of DA, norepinephrine (NE), serotonin (5-HT), or their metabolites in the arcuate nucleus (AN), medial preoptic area (MPA), caudate putamen (CP), substantia nigra (SN), and zona incerta (ZI), except for a decrease in 5-hydroxyindoleacetic acid (5-HIAA) in the AN after 6-months of hyperprolactinemia and an increase in DA concentrations in the AN after 9-months of hyperprolactinemia.	DA	hyperprolactinemia	9128918	-1
-There was no change in the levels of DA, norepinephrine (NE), serotonin (5-HT), or their metabolites in the arcuate nucleus (AN), medial preoptic area (MPA), caudate putamen (CP), substantia nigra (SN), and zona incerta (ZI), except for a decrease in 5-hydroxyindoleacetic acid (5-HIAA) in the AN after 6-months of hyperprolactinemia and an increase in DA concentrations in the AN after 9-months of hyperprolactinemia.	MPA	hyperprolactinemia	9128918	-1
-There was no change in the levels of DA, norepinephrine (NE), serotonin (5-HT), or their metabolites in the arcuate nucleus (AN), medial preoptic area (MPA), caudate putamen (CP), substantia nigra (SN), and zona incerta (ZI), except for a decrease in 5-hydroxyindoleacetic acid (5-HIAA) in the AN after 6-months of hyperprolactinemia and an increase in DA concentrations in the AN after 9-months of hyperprolactinemia.	MPA	hyperprolactinemia	9128918	-1
-There was no change in the levels of DA, norepinephrine (NE), serotonin (5-HT), or their metabolites in the arcuate nucleus (AN), medial preoptic area (MPA), caudate putamen (CP), substantia nigra (SN), and zona incerta (ZI), except for a decrease in 5-hydroxyindoleacetic acid (5-HIAA) in the AN after 6-months of hyperprolactinemia and an increase in DA concentrations in the AN after 9-months of hyperprolactinemia.	serotonin	hyperprolactinemia	9128918	-1
-There was no change in the levels of DA, norepinephrine (NE), serotonin (5-HT), or their metabolites in the arcuate nucleus (AN), medial preoptic area (MPA), caudate putamen (CP), substantia nigra (SN), and zona incerta (ZI), except for a decrease in 5-hydroxyindoleacetic acid (5-HIAA) in the AN after 6-months of hyperprolactinemia and an increase in DA concentrations in the AN after 9-months of hyperprolactinemia.	serotonin	hyperprolactinemia	9128918	-1
-There was no change in the levels of DA, norepinephrine (NE), serotonin (5-HT), or their metabolites in the arcuate nucleus (AN), medial preoptic area (MPA), caudate putamen (CP), substantia nigra (SN), and zona incerta (ZI), except for a decrease in 5-hydroxyindoleacetic acid (5-HIAA) in the AN after 6-months of hyperprolactinemia and an increase in DA concentrations in the AN after 9-months of hyperprolactinemia.	5-HT	hyperprolactinemia	9128918	-1
-There was no change in the levels of DA, norepinephrine (NE), serotonin (5-HT), or their metabolites in the arcuate nucleus (AN), medial preoptic area (MPA), caudate putamen (CP), substantia nigra (SN), and zona incerta (ZI), except for a decrease in 5-hydroxyindoleacetic acid (5-HIAA) in the AN after 6-months of hyperprolactinemia and an increase in DA concentrations in the AN after 9-months of hyperprolactinemia.	5-HT	hyperprolactinemia	9128918	-1
-There was no change in the levels of DA, norepinephrine (NE), serotonin (5-HT), or their metabolites in the arcuate nucleus (AN), medial preoptic area (MPA), caudate putamen (CP), substantia nigra (SN), and zona incerta (ZI), except for a decrease in 5-hydroxyindoleacetic acid (5-HIAA) in the AN after 6-months of hyperprolactinemia and an increase in DA concentrations in the AN after 9-months of hyperprolactinemia.	norepinephrine	hyperprolactinemia	9128918	-1
-There was no change in the levels of DA, norepinephrine (NE), serotonin (5-HT), or their metabolites in the arcuate nucleus (AN), medial preoptic area (MPA), caudate putamen (CP), substantia nigra (SN), and zona incerta (ZI), except for a decrease in 5-hydroxyindoleacetic acid (5-HIAA) in the AN after 6-months of hyperprolactinemia and an increase in DA concentrations in the AN after 9-months of hyperprolactinemia.	norepinephrine	hyperprolactinemia	9128918	-1
-There was no change in the levels of DA, norepinephrine (NE), serotonin (5-HT), or their metabolites in the arcuate nucleus (AN), medial preoptic area (MPA), caudate putamen (CP), substantia nigra (SN), and zona incerta (ZI), except for a decrease in 5-hydroxyindoleacetic acid (5-HIAA) in the AN after 6-months of hyperprolactinemia and an increase in DA concentrations in the AN after 9-months of hyperprolactinemia.	NE	hyperprolactinemia	9128918	-1
-There was no change in the levels of DA, norepinephrine (NE), serotonin (5-HT), or their metabolites in the arcuate nucleus (AN), medial preoptic area (MPA), caudate putamen (CP), substantia nigra (SN), and zona incerta (ZI), except for a decrease in 5-hydroxyindoleacetic acid (5-HIAA) in the AN after 6-months of hyperprolactinemia and an increase in DA concentrations in the AN after 9-months of hyperprolactinemia.	NE	hyperprolactinemia	9128918	-1
-Experimental hypertension created by the removal of NO, however, involves mechanisms in addition to decreased arterial vasodilator activity.	NO	hypertension	16810074	1
-Pilocarpine produced neuronal death in the hippocampus, which showed pyknotic changes.	Pilocarpine	neuronal death	9061777	1
-Treatment of compensatory gustatory hyperhidrosis with topical glycopyrrolate.	glycopyrrolate	hyperhidrosis	12950111	-1
-RESULTS: Short-term losartan treatment, besides antihypertensive effect, improved glomerular filtration rate and ameliorated glomerulosclerosis resulting in decreased proteinuria.	losartan	glomerulosclerosis	18987260	-1
-RESULTS: Short-term losartan treatment, besides antihypertensive effect, improved glomerular filtration rate and ameliorated glomerulosclerosis resulting in decreased proteinuria.	losartan	proteinuria	18987260	-1
-Prolonged treatment with losartan showed further reduction of glomerulosclerosis associated with reduced progression of tubular atrophy and interstitial fibrosis, thus preventing heavy proteinuria and chronic renal failure.	losartan	chronic renal failure	18987260	-1
-Prolonged treatment with losartan showed further reduction of glomerulosclerosis associated with reduced progression of tubular atrophy and interstitial fibrosis, thus preventing heavy proteinuria and chronic renal failure.	losartan	glomerulosclerosis	18987260	-1
-Prolonged treatment with losartan showed further reduction of glomerulosclerosis associated with reduced progression of tubular atrophy and interstitial fibrosis, thus preventing heavy proteinuria and chronic renal failure.	losartan	proteinuria	18987260	-1
-Prolonged treatment with losartan showed further reduction of glomerulosclerosis associated with reduced progression of tubular atrophy and interstitial fibrosis, thus preventing heavy proteinuria and chronic renal failure.	losartan	tubular atrophy	18987260	-1
-Prolonged treatment with losartan showed further reduction of glomerulosclerosis associated with reduced progression of tubular atrophy and interstitial fibrosis, thus preventing heavy proteinuria and chronic renal failure.	losartan	fibrosis	18987260	-1
-METHODS: Male pesticide applicators in Iowa and North Carolina reported lifetime diazinon use at enrolment (1993-1997) and follow-up (1998-2005); cancer incidence was assessed through 2010(North Carolina)/2011(Iowa).	diazinon	cancer	25907210	-1
-Aspirin does not seem to affect CVD mortality or all-cause mortality in either men or women.	Aspirin	CVD	19293073	-1
-Taken together, these results extend previous studies and demonstrate that cocaine-induced cardiac dysfunction may be due to a mitochondrial defect.	cocaine	cardiac dysfunction	20566328	1
-RESULTS: Postprocedural creatinine level decreased nonsignificantly in the PTRA group (1.46+/-0.8 vs. 1.34+/-0.5 mg/dl, P=NS) and increased significantly in the PCI group (1.44+/-0.6 vs. 1.57+/-0.7 mg/dl, P<0.02).	creatinine	NS	20192893	-1
-RESULTS: Postprocedural creatinine level decreased nonsignificantly in the PTRA group (1.46+/-0.8 vs. 1.34+/-0.5 mg/dl, P=NS) and increased significantly in the PCI group (1.44+/-0.6 vs. 1.57+/-0.7 mg/dl, P<0.02).	PTRA	NS	20192893	-1
-On admission, laboratory examination showed Plasmodium falciparum (++++), total bilirubin 8.25 mg/dL, conjugated bilirubin 4.36 mg/dL, unconjugated bilirubin 3.89 mg/dL, potassium 3.52 meq/L Patient was diagnosed as severe malaria with jaundice and got quinine infusion in dextrose 5% 500 mg/8 hour.	bilirubin	malaria	17297207	-1
-On admission, laboratory examination showed Plasmodium falciparum (++++), total bilirubin 8.25 mg/dL, conjugated bilirubin 4.36 mg/dL, unconjugated bilirubin 3.89 mg/dL, potassium 3.52 meq/L Patient was diagnosed as severe malaria with jaundice and got quinine infusion in dextrose 5% 500 mg/8 hour.	bilirubin	jaundice	17297207	-1
-On admission, laboratory examination showed Plasmodium falciparum (++++), total bilirubin 8.25 mg/dL, conjugated bilirubin 4.36 mg/dL, unconjugated bilirubin 3.89 mg/dL, potassium 3.52 meq/L Patient was diagnosed as severe malaria with jaundice and got quinine infusion in dextrose 5% 500 mg/8 hour.	bilirubin	malaria	17297207	-1
-On admission, laboratory examination showed Plasmodium falciparum (++++), total bilirubin 8.25 mg/dL, conjugated bilirubin 4.36 mg/dL, unconjugated bilirubin 3.89 mg/dL, potassium 3.52 meq/L Patient was diagnosed as severe malaria with jaundice and got quinine infusion in dextrose 5% 500 mg/8 hour.	bilirubin	jaundice	17297207	-1
-On admission, laboratory examination showed Plasmodium falciparum (++++), total bilirubin 8.25 mg/dL, conjugated bilirubin 4.36 mg/dL, unconjugated bilirubin 3.89 mg/dL, potassium 3.52 meq/L Patient was diagnosed as severe malaria with jaundice and got quinine infusion in dextrose 5% 500 mg/8 hour.	bilirubin	malaria	17297207	-1
-On admission, laboratory examination showed Plasmodium falciparum (++++), total bilirubin 8.25 mg/dL, conjugated bilirubin 4.36 mg/dL, unconjugated bilirubin 3.89 mg/dL, potassium 3.52 meq/L Patient was diagnosed as severe malaria with jaundice and got quinine infusion in dextrose 5% 500 mg/8 hour.	bilirubin	jaundice	17297207	-1
-On admission, laboratory examination showed Plasmodium falciparum (++++), total bilirubin 8.25 mg/dL, conjugated bilirubin 4.36 mg/dL, unconjugated bilirubin 3.89 mg/dL, potassium 3.52 meq/L Patient was diagnosed as severe malaria with jaundice and got quinine infusion in dextrose 5% 500 mg/8 hour.	Plasmodium falciparum	malaria	17297207	-1
-On admission, laboratory examination showed Plasmodium falciparum (++++), total bilirubin 8.25 mg/dL, conjugated bilirubin 4.36 mg/dL, unconjugated bilirubin 3.89 mg/dL, potassium 3.52 meq/L Patient was diagnosed as severe malaria with jaundice and got quinine infusion in dextrose 5% 500 mg/8 hour.	Plasmodium falciparum	jaundice	17297207	-1
-On admission, laboratory examination showed Plasmodium falciparum (++++), total bilirubin 8.25 mg/dL, conjugated bilirubin 4.36 mg/dL, unconjugated bilirubin 3.89 mg/dL, potassium 3.52 meq/L Patient was diagnosed as severe malaria with jaundice and got quinine infusion in dextrose 5% 500 mg/8 hour.	potassium	malaria	17297207	-1
-On admission, laboratory examination showed Plasmodium falciparum (++++), total bilirubin 8.25 mg/dL, conjugated bilirubin 4.36 mg/dL, unconjugated bilirubin 3.89 mg/dL, potassium 3.52 meq/L Patient was diagnosed as severe malaria with jaundice and got quinine infusion in dextrose 5% 500 mg/8 hour.	potassium	jaundice	17297207	-1
-On admission, laboratory examination showed Plasmodium falciparum (++++), total bilirubin 8.25 mg/dL, conjugated bilirubin 4.36 mg/dL, unconjugated bilirubin 3.89 mg/dL, potassium 3.52 meq/L Patient was diagnosed as severe malaria with jaundice and got quinine infusion in dextrose 5% 500 mg/8 hour.	dextrose	malaria	17297207	-1
-On admission, laboratory examination showed Plasmodium falciparum (++++), total bilirubin 8.25 mg/dL, conjugated bilirubin 4.36 mg/dL, unconjugated bilirubin 3.89 mg/dL, potassium 3.52 meq/L Patient was diagnosed as severe malaria with jaundice and got quinine infusion in dextrose 5% 500 mg/8 hour.	dextrose	jaundice	17297207	-1
-On admission, laboratory examination showed Plasmodium falciparum (++++), total bilirubin 8.25 mg/dL, conjugated bilirubin 4.36 mg/dL, unconjugated bilirubin 3.89 mg/dL, potassium 3.52 meq/L Patient was diagnosed as severe malaria with jaundice and got quinine infusion in dextrose 5% 500 mg/8 hour.	quinine	malaria	17297207	-1
-On admission, laboratory examination showed Plasmodium falciparum (++++), total bilirubin 8.25 mg/dL, conjugated bilirubin 4.36 mg/dL, unconjugated bilirubin 3.89 mg/dL, potassium 3.52 meq/L Patient was diagnosed as severe malaria with jaundice and got quinine infusion in dextrose 5% 500 mg/8 hour.	quinine	jaundice	17297207	-1
-Serological evidence for Epstein Barr Virus infection was found in 20% of 65 cyclosporine patients studied.	cyclosporine	Epstein Barr Virus infection	6310832	-1
-In contrast, haloperidol demonstrated an ability to reduce cocaine-induced seizures without significantly reducing mortality.	cocaine	seizures	2625524	1
-In contrast, haloperidol demonstrated an ability to reduce cocaine-induced seizures without significantly reducing mortality.	haloperidol	seizures	2625524	-1
-CONCLUSION: No exaggerated adrenergic response was detected when dobutamine was administered to patients with cocaine-related chest pain.	cocaine	chest pain	11423811	1
-CONCLUSION: No exaggerated adrenergic response was detected when dobutamine was administered to patients with cocaine-related chest pain.	dobutamine	chest pain	11423811	-1
-A comparison of glyceryl trinitrate with diclofenac for the treatment of primary dysmenorrhea: an open, randomized, cross-over trial.	glyceryl trinitrate	primary dysmenorrhea	11915580	-1
-A comparison of glyceryl trinitrate with diclofenac for the treatment of primary dysmenorrhea: an open, randomized, cross-over trial.	diclofenac	primary dysmenorrhea	11915580	-1
-Long-term lithium therapy leading to hyperparathyroidism: a case report.	lithium	hyperparathyroidism	19154241	1
-Increased serum soluble Fas in patients with acute liver failure due to paracetamol overdose.	paracetamol	overdose	12828076	-1
-Increased serum soluble Fas in patients with acute liver failure due to paracetamol overdose.	paracetamol	acute liver failure	12828076	1
-We conclude that: 1) administration of rhIGF-I improves growth and GFR in rats with chronic PAN nephropathy and 2) unlike rhGH, long-term use of rhIGF-I does not worsen renal functional and structural injury in this disease model.	PAN	nephropathy	8825380	1
-We conclude that: 1) administration of rhIGF-I improves growth and GFR in rats with chronic PAN nephropathy and 2) unlike rhGH, long-term use of rhIGF-I does not worsen renal functional and structural injury in this disease model.	PAN	structural injury	8825380	-1
-Primary dysmenorrhea is a syndrome characterized by painful uterine contractility caused by a hypersecretion of endometrial prostaglandins; non-steroidal anti-inflammatory drugs are the first choice for its treatment.	prostaglandins	painful	11915580	-1
-Primary dysmenorrhea is a syndrome characterized by painful uterine contractility caused by a hypersecretion of endometrial prostaglandins; non-steroidal anti-inflammatory drugs are the first choice for its treatment.	prostaglandins	Primary dysmenorrhea	11915580	-1
-Primary dysmenorrhea is a syndrome characterized by painful uterine contractility caused by a hypersecretion of endometrial prostaglandins; non-steroidal anti-inflammatory drugs are the first choice for its treatment.	prostaglandins	endometrial	11915580	-1
-Comparison of the two biopsies showed that temsirolimus inhibited tumor cell proliferation through cell cycle arrest, but did not induce any change in the number of apoptotic tumor cells.	temsirolimus	tumor	20828385	-1
-Comparison of the two biopsies showed that temsirolimus inhibited tumor cell proliferation through cell cycle arrest, but did not induce any change in the number of apoptotic tumor cells.	temsirolimus	tumor	20828385	-1
-The aim of the present study was to determine the efficacy of glyceryl trinitrate (GTN), an NO donor, in the resolution of primary dysmenorrhea in comparison with diclofenac (DCF).	glyceryl trinitrate	primary dysmenorrhea	11915580	-1
-The aim of the present study was to determine the efficacy of glyceryl trinitrate (GTN), an NO donor, in the resolution of primary dysmenorrhea in comparison with diclofenac (DCF).	GTN	primary dysmenorrhea	11915580	-1
-The aim of the present study was to determine the efficacy of glyceryl trinitrate (GTN), an NO donor, in the resolution of primary dysmenorrhea in comparison with diclofenac (DCF).	NO	primary dysmenorrhea	11915580	-1
-The aim of the present study was to determine the efficacy of glyceryl trinitrate (GTN), an NO donor, in the resolution of primary dysmenorrhea in comparison with diclofenac (DCF).	diclofenac	primary dysmenorrhea	11915580	-1
-The aim of the present study was to determine the efficacy of glyceryl trinitrate (GTN), an NO donor, in the resolution of primary dysmenorrhea in comparison with diclofenac (DCF).	DCF	primary dysmenorrhea	11915580	-1
-Since bupivacaine and epinephrine may both precipitate dysrhythmias, circulating bupivacaine during regional anesthesia could potentiate dysrhythmogenic effects of epinephrine.	epinephrine	dysrhythmias	8659767	-1
-Since bupivacaine and epinephrine may both precipitate dysrhythmias, circulating bupivacaine during regional anesthesia could potentiate dysrhythmogenic effects of epinephrine.	epinephrine	dysrhythmias	8659767	-1
-Since bupivacaine and epinephrine may both precipitate dysrhythmias, circulating bupivacaine during regional anesthesia could potentiate dysrhythmogenic effects of epinephrine.	bupivacaine	dysrhythmias	8659767	-1
-Since bupivacaine and epinephrine may both precipitate dysrhythmias, circulating bupivacaine during regional anesthesia could potentiate dysrhythmogenic effects of epinephrine.	bupivacaine	dysrhythmias	8659767	-1
-CONCLUSIONS: We conclude that pretreatment with fentanyl or combination of fentanyl and midazolam was effective in preventing etomidate-induced myoclonus.	midazolam	myoclonus	24535067	-1
-CONCLUSIONS: We conclude that pretreatment with fentanyl or combination of fentanyl and midazolam was effective in preventing etomidate-induced myoclonus.	fentanyl	myoclonus	24535067	-1
-CONCLUSIONS: We conclude that pretreatment with fentanyl or combination of fentanyl and midazolam was effective in preventing etomidate-induced myoclonus.	fentanyl	myoclonus	24535067	-1
-CONCLUSIONS: We conclude that pretreatment with fentanyl or combination of fentanyl and midazolam was effective in preventing etomidate-induced myoclonus.	etomidate	myoclonus	24535067	1
-Anticonvulsant actions of MK-801 on the lithium-pilocarpine model of status epilepticus in rats.	MK-801	status epilepticus	2553470	-1
-Anticonvulsant actions of MK-801 on the lithium-pilocarpine model of status epilepticus in rats.	pilocarpine	status epilepticus	2553470	1
-Combination of bortezomib, thalidomide, and dexamethasone (VTD) as a consolidation therapy after autologous stem cell transplantation for symptomatic multiple myeloma in Japanese patients.	bortezomib	multiple myeloma	24928523	-1
-Combination of bortezomib, thalidomide, and dexamethasone (VTD) as a consolidation therapy after autologous stem cell transplantation for symptomatic multiple myeloma in Japanese patients.	dexamethasone	multiple myeloma	24928523	-1
-Combination of bortezomib, thalidomide, and dexamethasone (VTD) as a consolidation therapy after autologous stem cell transplantation for symptomatic multiple myeloma in Japanese patients.	thalidomide	multiple myeloma	24928523	-1
-Sotalol-induced coronary spasm in a patient with dilated cardiomyopathy associated with sustained ventricular tachycardia.	Sotalol	dilated cardiomyopathy	15609701	-1
-Sotalol-induced coronary spasm in a patient with dilated cardiomyopathy associated with sustained ventricular tachycardia.	Sotalol	ventricular tachycardia	15609701	-1
-Levels were significantly greater in patients with acute liver failure due to paracetamol overdose (median, 28.7 U/mL; range, 12.8-52.7 U/mL, n = 17) than those due to non-A to E hepatitis (median, 12.5 U/mL; range, 6.9-46.0 U/mL, n = 7, P < 0.01).	paracetamol	hepatitis	12828076	-1
-Levels were significantly greater in patients with acute liver failure due to paracetamol overdose (median, 28.7 U/mL; range, 12.8-52.7 U/mL, n = 17) than those due to non-A to E hepatitis (median, 12.5 U/mL; range, 6.9-46.0 U/mL, n = 7, P < 0.01).	paracetamol	overdose	12828076	-1
-Levels were significantly greater in patients with acute liver failure due to paracetamol overdose (median, 28.7 U/mL; range, 12.8-52.7 U/mL, n = 17) than those due to non-A to E hepatitis (median, 12.5 U/mL; range, 6.9-46.0 U/mL, n = 7, P < 0.01).	paracetamol	acute liver failure	12828076	1
-Heparin-induced thrombocytopenia (HIT) remains under-recognized despite its potentially devastating outcomes.	Heparin	thrombocytopenia	20495512	1
-Salicylate nephropathy in the Gunn rat: potential role of prostaglandins.	prostaglandins	nephropathy	3864191	-1
-Salicylate nephropathy in the Gunn rat: potential role of prostaglandins.	Salicylate	nephropathy	3864191	-1
-Examination of CCL2 expression showed that it was elevated in the hippocampus following SE.	CCL2	SE	20034406	-1
-After 30 hours of quinine infusion the patient felt palpitation and electrocardiography (ECG) recording showed premature ventricular contraction (PVC) > 5 x/minute, trigemini, constant type--sinoatrial block, positive U wave.	quinine	sinoatrial block	17297207	-1
-After 30 hours of quinine infusion the patient felt palpitation and electrocardiography (ECG) recording showed premature ventricular contraction (PVC) > 5 x/minute, trigemini, constant type--sinoatrial block, positive U wave.	quinine	PVC	17297207	1
-CONCLUSION: A single 10-, 20-, or 40-micrograms/kg dose of granisetron was effective in controlling vomiting in 57% to 60% of patients who received cisplatin at doses greater than 81 mg/m2 and totally prevented vomiting in 40% to 47% of patients.	granisetron	vomiting	7931490	-1
-CONCLUSION: A single 10-, 20-, or 40-micrograms/kg dose of granisetron was effective in controlling vomiting in 57% to 60% of patients who received cisplatin at doses greater than 81 mg/m2 and totally prevented vomiting in 40% to 47% of patients.	granisetron	vomiting	7931490	-1
-CONCLUSION: A single 10-, 20-, or 40-micrograms/kg dose of granisetron was effective in controlling vomiting in 57% to 60% of patients who received cisplatin at doses greater than 81 mg/m2 and totally prevented vomiting in 40% to 47% of patients.	cisplatin	vomiting	7931490	1
-We report on rosaceiform dermatitis as a complication of treatment with tacrolimus ointment.	tacrolimus	dermatitis	15096374	-1
-It is concluded that oxidative tubular damage plays an important role in the VCM-induced nephrotoxicity and the modulation of oxidative stress with erdosteine reduces the VCM-induced kidney damage both at the biochemical and histological levels.	VCM	nephrotoxicity	16112787	1
-It is concluded that oxidative tubular damage plays an important role in the VCM-induced nephrotoxicity and the modulation of oxidative stress with erdosteine reduces the VCM-induced kidney damage both at the biochemical and histological levels.	VCM	nephrotoxicity	16112787	1
-It is concluded that oxidative tubular damage plays an important role in the VCM-induced nephrotoxicity and the modulation of oxidative stress with erdosteine reduces the VCM-induced kidney damage both at the biochemical and histological levels.	erdosteine	nephrotoxicity	16112787	-1
-It is concluded that oxidative tubular damage plays an important role in the VCM-induced nephrotoxicity and the modulation of oxidative stress with erdosteine reduces the VCM-induced kidney damage both at the biochemical and histological levels.	erdosteine	kidney damage	16112787	-1
-One female patient with stable cardiac disease had recurrent torsades de pointes after 2 years of successful treatment with d,l-sotalol.	l-sotalol	cardiac disease	9125676	-1
-One female patient with stable cardiac disease had recurrent torsades de pointes after 2 years of successful treatment with d,l-sotalol.	l-sotalol	torsades de pointes	9125676	1
-RESULTS: The bupivacaine/rofecoxib group reported significantly less pain, as assessed by a visual analog scale, compared with the other three treatment groups over the first 4 h. However, the bupivacaine/placebo group reported significantly more pain at 24 h and PGE2 levels during the first 4 h were significantly higher than the other three treatment groups.	PGE2	pain	18165598	-1
-RESULTS: The bupivacaine/rofecoxib group reported significantly less pain, as assessed by a visual analog scale, compared with the other three treatment groups over the first 4 h. However, the bupivacaine/placebo group reported significantly more pain at 24 h and PGE2 levels during the first 4 h were significantly higher than the other three treatment groups.	PGE2	pain	18165598	-1
-RESULTS: The bupivacaine/rofecoxib group reported significantly less pain, as assessed by a visual analog scale, compared with the other three treatment groups over the first 4 h. However, the bupivacaine/placebo group reported significantly more pain at 24 h and PGE2 levels during the first 4 h were significantly higher than the other three treatment groups.	rofecoxib	pain	18165598	-1
-RESULTS: The bupivacaine/rofecoxib group reported significantly less pain, as assessed by a visual analog scale, compared with the other three treatment groups over the first 4 h. However, the bupivacaine/placebo group reported significantly more pain at 24 h and PGE2 levels during the first 4 h were significantly higher than the other three treatment groups.	rofecoxib	pain	18165598	-1
-RESULTS: The bupivacaine/rofecoxib group reported significantly less pain, as assessed by a visual analog scale, compared with the other three treatment groups over the first 4 h. However, the bupivacaine/placebo group reported significantly more pain at 24 h and PGE2 levels during the first 4 h were significantly higher than the other three treatment groups.	bupivacaine	pain	18165598	-1
-RESULTS: The bupivacaine/rofecoxib group reported significantly less pain, as assessed by a visual analog scale, compared with the other three treatment groups over the first 4 h. However, the bupivacaine/placebo group reported significantly more pain at 24 h and PGE2 levels during the first 4 h were significantly higher than the other three treatment groups.	bupivacaine	pain	18165598	-1
-RESULTS: The bupivacaine/rofecoxib group reported significantly less pain, as assessed by a visual analog scale, compared with the other three treatment groups over the first 4 h. However, the bupivacaine/placebo group reported significantly more pain at 24 h and PGE2 levels during the first 4 h were significantly higher than the other three treatment groups.	bupivacaine	pain	18165598	-1
-RESULTS: The bupivacaine/rofecoxib group reported significantly less pain, as assessed by a visual analog scale, compared with the other three treatment groups over the first 4 h. However, the bupivacaine/placebo group reported significantly more pain at 24 h and PGE2 levels during the first 4 h were significantly higher than the other three treatment groups.	bupivacaine	pain	18165598	-1
-With provision of adequate oleic acid as a substrate for the isolated perfused liver, a direct relationship was observed between dose of tetracycline and both accumulation of triglyceride in the liver and depression of output of triglyceride by livers from male and female rats.	tetracycline	depression	1158089	-1
-With provision of adequate oleic acid as a substrate for the isolated perfused liver, a direct relationship was observed between dose of tetracycline and both accumulation of triglyceride in the liver and depression of output of triglyceride by livers from male and female rats.	triglyceride	depression	1158089	-1
-With provision of adequate oleic acid as a substrate for the isolated perfused liver, a direct relationship was observed between dose of tetracycline and both accumulation of triglyceride in the liver and depression of output of triglyceride by livers from male and female rats.	triglyceride	depression	1158089	-1
-The one case of toxic epidermal necrolysis occurred in a patient who took cephalexin.	cephalexin	epidermal necrolysis	7479194	1
-Randomized comparison of olanzapine versus risperidone for the treatment of first-episode schizophrenia: 4-month outcomes.	risperidone	schizophrenia	17151160	-1
-Randomized comparison of olanzapine versus risperidone for the treatment of first-episode schizophrenia: 4-month outcomes.	olanzapine	schizophrenia	17151160	-1
-OBJECTIVE: To examine the effects of dehydroepiandrosterone (DHEA) on animal models of schizophrenia.	dehydroepiandrosterone	schizophrenia	24739405	-1
-OBJECTIVE: To examine the effects of dehydroepiandrosterone (DHEA) on animal models of schizophrenia.	DHEA	schizophrenia	24739405	-1
-Scopolamine, but not methyl scopolamine (1 and 3 mg/kg), induced an amnesia as measured by latency and duration parameters.	Scopolamine	amnesia	3088653	1
-Scopolamine, but not methyl scopolamine (1 and 3 mg/kg), induced an amnesia as measured by latency and duration parameters.	methyl scopolamine	amnesia	3088653	1
-Concomitant use of oral prednisone and topical beclomethasone may increase the risk of developing hoarseness or candidiasis.	prednisone	hoarseness	3475563	-1
-Concomitant use of oral prednisone and topical beclomethasone may increase the risk of developing hoarseness or candidiasis.	prednisone	candidiasis	3475563	-1
-Concomitant use of oral prednisone and topical beclomethasone may increase the risk of developing hoarseness or candidiasis.	beclomethasone	candidiasis	3475563	-1
-Periodic monitoring of cerebruspinal fluid methotrexate levels may be predictive of the development of serious neurotoxicity.	methotrexate	neurotoxicity	946593	-1
-Antirifampicin antibodies in acute rifampicin-associated renal failure. 5 patients with acute renal failure (3 with thrombopenia and hemolysis) induced by the reintroduction of rifampicin are described.	rifampicin	acute renal failure	7121659	-1
-Antirifampicin antibodies in acute rifampicin-associated renal failure. 5 patients with acute renal failure (3 with thrombopenia and hemolysis) induced by the reintroduction of rifampicin are described.	rifampicin	thrombopenia	7121659	1
-Antirifampicin antibodies in acute rifampicin-associated renal failure. 5 patients with acute renal failure (3 with thrombopenia and hemolysis) induced by the reintroduction of rifampicin are described.	rifampicin	renal failure	7121659	-1
-Antirifampicin antibodies in acute rifampicin-associated renal failure. 5 patients with acute renal failure (3 with thrombopenia and hemolysis) induced by the reintroduction of rifampicin are described.	rifampicin	acute renal failure	7121659	-1
-Antirifampicin antibodies in acute rifampicin-associated renal failure. 5 patients with acute renal failure (3 with thrombopenia and hemolysis) induced by the reintroduction of rifampicin are described.	rifampicin	hemolysis	7121659	1
-Antirifampicin antibodies in acute rifampicin-associated renal failure. 5 patients with acute renal failure (3 with thrombopenia and hemolysis) induced by the reintroduction of rifampicin are described.	rifampicin	renal failure	7121659	-1
-However, livers from female, and especially pregnant female rats, were strikingly resistant to the effects of tetracycline on depression of output of triglyceride under these experimental conditions.	tetracycline	depression	1158089	-1
-However, livers from female, and especially pregnant female rats, were strikingly resistant to the effects of tetracycline on depression of output of triglyceride under these experimental conditions.	triglyceride	depression	1158089	-1
-It is the third urinary tract cancer reported in association with cyclophosphamide treatment for nonmalignant disease.	cyclophosphamide	cancer	7248895	-1
-Although several new anticoagulant drugs are in development, heparin remains the anticoagulant of choice to treat acute thrombotic episodes.	heparin	thrombotic	10726030	-1
-Paclitaxel, 5-fluorouracil, and folinic acid in metastatic breast cancer: BRE-26, a phase II trial.	Paclitaxel	breast cancer	9071336	-1
-Paclitaxel, 5-fluorouracil, and folinic acid in metastatic breast cancer: BRE-26, a phase II trial.	5-fluorouracil	breast cancer	9071336	-1
-Paclitaxel, 5-fluorouracil, and folinic acid in metastatic breast cancer: BRE-26, a phase II trial.	folinic acid	breast cancer	9071336	-1
-Depressed hepatic secretion of triglyceride accounted only for 30 to 50% of accumulated hepatic triglyceride, indicating that additional mechanisms must be involved in the production of the triglyceride-rich fatty liver in response to tetracycline.	tetracycline	Depressed	1158089	-1
-Depressed hepatic secretion of triglyceride accounted only for 30 to 50% of accumulated hepatic triglyceride, indicating that additional mechanisms must be involved in the production of the triglyceride-rich fatty liver in response to tetracycline.	triglyceride	Depressed	1158089	-1
-Depressed hepatic secretion of triglyceride accounted only for 30 to 50% of accumulated hepatic triglyceride, indicating that additional mechanisms must be involved in the production of the triglyceride-rich fatty liver in response to tetracycline.	triglyceride	Depressed	1158089	-1
-Depressed hepatic secretion of triglyceride accounted only for 30 to 50% of accumulated hepatic triglyceride, indicating that additional mechanisms must be involved in the production of the triglyceride-rich fatty liver in response to tetracycline.	triglyceride	Depressed	1158089	-1
-Amphetamine (3 mg/kg ip) induced hyper locomotion, apomorphine (1.5 mg/kg subcutaneously [sc]) induced climbing, and haloperidol (1.5 mg/kg sc) induced catalepsy tests were used as animal models of schizophrenia.	haloperidol	hyper locomotion	24739405	-1
-Amphetamine (3 mg/kg ip) induced hyper locomotion, apomorphine (1.5 mg/kg subcutaneously [sc]) induced climbing, and haloperidol (1.5 mg/kg sc) induced catalepsy tests were used as animal models of schizophrenia.	haloperidol	catalepsy	24739405	1
-Amphetamine (3 mg/kg ip) induced hyper locomotion, apomorphine (1.5 mg/kg subcutaneously [sc]) induced climbing, and haloperidol (1.5 mg/kg sc) induced catalepsy tests were used as animal models of schizophrenia.	haloperidol	schizophrenia	24739405	1
-Amphetamine (3 mg/kg ip) induced hyper locomotion, apomorphine (1.5 mg/kg subcutaneously [sc]) induced climbing, and haloperidol (1.5 mg/kg sc) induced catalepsy tests were used as animal models of schizophrenia.	Amphetamine	hyper locomotion	24739405	-1
-Amphetamine (3 mg/kg ip) induced hyper locomotion, apomorphine (1.5 mg/kg subcutaneously [sc]) induced climbing, and haloperidol (1.5 mg/kg sc) induced catalepsy tests were used as animal models of schizophrenia.	Amphetamine	catalepsy	24739405	-1
-Amphetamine (3 mg/kg ip) induced hyper locomotion, apomorphine (1.5 mg/kg subcutaneously [sc]) induced climbing, and haloperidol (1.5 mg/kg sc) induced catalepsy tests were used as animal models of schizophrenia.	apomorphine	hyper locomotion	24739405	-1
-Amphetamine (3 mg/kg ip) induced hyper locomotion, apomorphine (1.5 mg/kg subcutaneously [sc]) induced climbing, and haloperidol (1.5 mg/kg sc) induced catalepsy tests were used as animal models of schizophrenia.	apomorphine	catalepsy	24739405	-1
-Amphetamine (3 mg/kg ip) induced hyper locomotion, apomorphine (1.5 mg/kg subcutaneously [sc]) induced climbing, and haloperidol (1.5 mg/kg sc) induced catalepsy tests were used as animal models of schizophrenia.	apomorphine	schizophrenia	24739405	1
-GEM-P is a salvage chemotherapy with relatively high response rates, leading to successful transplantation in appropriate patients, in the treatment of relapsed or refractory HL.	GEM	HL	24158386	-1
-We performed a phase II trial of paclitaxel 175 mg/m2 over 3 hours on day I followed by folinic acid 300 mg over 1 hour before 5-fluorouracil 350 mg/m2 on days 1 to 3 every 28 days (TFL) in women with metastatic breast cancer.	paclitaxel	breast cancer	9071336	-1
-We performed a phase II trial of paclitaxel 175 mg/m2 over 3 hours on day I followed by folinic acid 300 mg over 1 hour before 5-fluorouracil 350 mg/m2 on days 1 to 3 every 28 days (TFL) in women with metastatic breast cancer.	5-fluorouracil	breast cancer	9071336	-1
-We performed a phase II trial of paclitaxel 175 mg/m2 over 3 hours on day I followed by folinic acid 300 mg over 1 hour before 5-fluorouracil 350 mg/m2 on days 1 to 3 every 28 days (TFL) in women with metastatic breast cancer.	folinic acid	breast cancer	9071336	-1
-Attenuation of nephrotoxicity by a novel lipid nanosphere (NS-718) incorporating amphotericin B. NS-718, a lipid nanosphere incorporating amphotericin B, is effective against pathogenic fungi and has low toxicity.	amphotericin B.	NS-718	10933650	-1
-Attenuation of nephrotoxicity by a novel lipid nanosphere (NS-718) incorporating amphotericin B. NS-718, a lipid nanosphere incorporating amphotericin B, is effective against pathogenic fungi and has low toxicity.	amphotericin B.	toxicity	10933650	-1
-Attenuation of nephrotoxicity by a novel lipid nanosphere (NS-718) incorporating amphotericin B. NS-718, a lipid nanosphere incorporating amphotericin B, is effective against pathogenic fungi and has low toxicity.	amphotericin B.	nephrotoxicity	10933650	-1
-Attenuation of nephrotoxicity by a novel lipid nanosphere (NS-718) incorporating amphotericin B. NS-718, a lipid nanosphere incorporating amphotericin B, is effective against pathogenic fungi and has low toxicity.	amphotericin B	NS-718	10933650	-1
-Attenuation of nephrotoxicity by a novel lipid nanosphere (NS-718) incorporating amphotericin B. NS-718, a lipid nanosphere incorporating amphotericin B, is effective against pathogenic fungi and has low toxicity.	amphotericin B	toxicity	10933650	-1
-Attenuation of nephrotoxicity by a novel lipid nanosphere (NS-718) incorporating amphotericin B. NS-718, a lipid nanosphere incorporating amphotericin B, is effective against pathogenic fungi and has low toxicity.	amphotericin B	nephrotoxicity	10933650	-1
-Recent findings in a bipolar patient receiving maintenance lithium therapy who developed hypercalcemia and severe bradyarrhythmia prompted the authors to conduct a retrospective study of bipolar patients with lithium-associated hypercalcemia.	lithium	bipolar	10770468	-1
-Recent findings in a bipolar patient receiving maintenance lithium therapy who developed hypercalcemia and severe bradyarrhythmia prompted the authors to conduct a retrospective study of bipolar patients with lithium-associated hypercalcemia.	lithium	bipolar	10770468	-1
-Recent findings in a bipolar patient receiving maintenance lithium therapy who developed hypercalcemia and severe bradyarrhythmia prompted the authors to conduct a retrospective study of bipolar patients with lithium-associated hypercalcemia.	lithium	hypercalcemia	10770468	1
-Recent findings in a bipolar patient receiving maintenance lithium therapy who developed hypercalcemia and severe bradyarrhythmia prompted the authors to conduct a retrospective study of bipolar patients with lithium-associated hypercalcemia.	lithium	hypercalcemia	10770468	1
-Recent findings in a bipolar patient receiving maintenance lithium therapy who developed hypercalcemia and severe bradyarrhythmia prompted the authors to conduct a retrospective study of bipolar patients with lithium-associated hypercalcemia.	lithium	bradyarrhythmia	10770468	-1
-Recent findings in a bipolar patient receiving maintenance lithium therapy who developed hypercalcemia and severe bradyarrhythmia prompted the authors to conduct a retrospective study of bipolar patients with lithium-associated hypercalcemia.	lithium	bipolar	10770468	-1
-Recent findings in a bipolar patient receiving maintenance lithium therapy who developed hypercalcemia and severe bradyarrhythmia prompted the authors to conduct a retrospective study of bipolar patients with lithium-associated hypercalcemia.	lithium	bipolar	10770468	-1
-Recent findings in a bipolar patient receiving maintenance lithium therapy who developed hypercalcemia and severe bradyarrhythmia prompted the authors to conduct a retrospective study of bipolar patients with lithium-associated hypercalcemia.	lithium	hypercalcemia	10770468	1
-Recent findings in a bipolar patient receiving maintenance lithium therapy who developed hypercalcemia and severe bradyarrhythmia prompted the authors to conduct a retrospective study of bipolar patients with lithium-associated hypercalcemia.	lithium	hypercalcemia	10770468	1
-Recent findings in a bipolar patient receiving maintenance lithium therapy who developed hypercalcemia and severe bradyarrhythmia prompted the authors to conduct a retrospective study of bipolar patients with lithium-associated hypercalcemia.	lithium	bradyarrhythmia	10770468	-1
-Amiodarone induced hepatomegaly, hepatocyte microvesicular lipid accumulation, and a significant decrease in serum triglycerides and glucose.	Amiodarone	hepatomegaly	15265979	1
-Amiodarone induced hepatomegaly, hepatocyte microvesicular lipid accumulation, and a significant decrease in serum triglycerides and glucose.	triglycerides	hepatomegaly	15265979	-1
-Amiodarone induced hepatomegaly, hepatocyte microvesicular lipid accumulation, and a significant decrease in serum triglycerides and glucose.	glucose	hepatomegaly	15265979	-1
-Careful attention to renal function and potassium balance in patients receiving indomethacin or other nonsteroidal anti-inflammatory agents, particularly in those patients with diabetes mellitus or preexisting renal disease, will help prevent this potentially serious complication.	indomethacin	diabetes mellitus	7411769	-1
-Careful attention to renal function and potassium balance in patients receiving indomethacin or other nonsteroidal anti-inflammatory agents, particularly in those patients with diabetes mellitus or preexisting renal disease, will help prevent this potentially serious complication.	indomethacin	renal disease	7411769	-1
-Careful attention to renal function and potassium balance in patients receiving indomethacin or other nonsteroidal anti-inflammatory agents, particularly in those patients with diabetes mellitus or preexisting renal disease, will help prevent this potentially serious complication.	potassium	diabetes mellitus	7411769	-1
-Careful attention to renal function and potassium balance in patients receiving indomethacin or other nonsteroidal anti-inflammatory agents, particularly in those patients with diabetes mellitus or preexisting renal disease, will help prevent this potentially serious complication.	potassium	renal disease	7411769	-1
-Headache was significantly increased by GTN but not by DCF.	GTN	Headache	11915580	1
-Headache was significantly increased by GTN but not by DCF.	DCF	Headache	11915580	-1
-These results demonstrate that hyperprolactinemia specifically affects TIDA neurons and these effects vary, depending on the duration and intensity of hyperprolactinemia.	TIDA	hyperprolactinemia	9128918	-1
-These results demonstrate that hyperprolactinemia specifically affects TIDA neurons and these effects vary, depending on the duration and intensity of hyperprolactinemia.	TIDA	hyperprolactinemia	9128918	-1
-Protective effect of clentiazem against epinephrine-induced cardiac injury in rats.	epinephrine	cardiac injury	8392553	-1
-Protective effect of clentiazem against epinephrine-induced cardiac injury in rats.	clentiazem	cardiac injury	8392553	-1
-There was a significant difference between groups in the haloperidol-induced catalepsy test (p<0.05).	haloperidol	catalepsy	24739405	1
-Estrogen binding sites were demonstrated by autoradiography in one transplantable and five primary diethylstilbesterol induced renal carcinomas in three hamsters.	diethylstilbesterol	renal carcinomas	2650911	-1
-METHOD: Twenty-three patients suffering from severe Parkinson's disease (Stages III-V on Hoehn and Yahr scale) and, particularly bradykinesia, rigidity, and levodopa-induced dyskinesias underwent bilateral implantation of electrodes in the STN.	levodopa	rigidity	12865514	-1
-METHOD: Twenty-three patients suffering from severe Parkinson's disease (Stages III-V on Hoehn and Yahr scale) and, particularly bradykinesia, rigidity, and levodopa-induced dyskinesias underwent bilateral implantation of electrodes in the STN.	levodopa	Parkinson's disease	12865514	-1
-METHOD: Twenty-three patients suffering from severe Parkinson's disease (Stages III-V on Hoehn and Yahr scale) and, particularly bradykinesia, rigidity, and levodopa-induced dyskinesias underwent bilateral implantation of electrodes in the STN.	levodopa	dyskinesias	12865514	1
-METHOD: Twenty-three patients suffering from severe Parkinson's disease (Stages III-V on Hoehn and Yahr scale) and, particularly bradykinesia, rigidity, and levodopa-induced dyskinesias underwent bilateral implantation of electrodes in the STN.	levodopa	bradykinesia	12865514	-1
-Torsade de pointes ventricular tachycardia during low dose intermittent dobutamine treatment in a patient with dilated cardiomyopathy and congestive heart failure.	dobutamine	dilated cardiomyopathy	10087562	-1
-Torsade de pointes ventricular tachycardia during low dose intermittent dobutamine treatment in a patient with dilated cardiomyopathy and congestive heart failure.	dobutamine	congestive heart failure	10087562	-1
-Torsade de pointes ventricular tachycardia during low dose intermittent dobutamine treatment in a patient with dilated cardiomyopathy and congestive heart failure.	dobutamine	Torsade de pointes	10087562	1
-Torsade de pointes ventricular tachycardia during low dose intermittent dobutamine treatment in a patient with dilated cardiomyopathy and congestive heart failure.	dobutamine	ventricular tachycardia	10087562	-1
-These findings indicate that GTN has a reduced efficacy and tolerability by comparison with DCF in the treatment of primary dysmenorrhea.	GTN	primary dysmenorrhea	11915580	-1
-These findings indicate that GTN has a reduced efficacy and tolerability by comparison with DCF in the treatment of primary dysmenorrhea.	DCF	primary dysmenorrhea	11915580	-1
-OBJECTIVE: This study determined the antihyperalgesic effect of CNSB002, a sodium channel blocker with antioxidant properties given alone and in combinations with morphine in rat models of inflammatory and neuropathic pain.	CNSB002	neuropathic pain	20447294	-1
-OBJECTIVE: This study determined the antihyperalgesic effect of CNSB002, a sodium channel blocker with antioxidant properties given alone and in combinations with morphine in rat models of inflammatory and neuropathic pain.	morphine	neuropathic pain	20447294	-1
-OBJECTIVE: This study determined the antihyperalgesic effect of CNSB002, a sodium channel blocker with antioxidant properties given alone and in combinations with morphine in rat models of inflammatory and neuropathic pain.	sodium	neuropathic pain	20447294	-1
-Fluoxetine, a selective serotonin reuptake inhibitor, is gaining increased acceptance in the treatment of adolescent depression.	Fluoxetine	depression	1564030	-1
-Fluoxetine, a selective serotonin reuptake inhibitor, is gaining increased acceptance in the treatment of adolescent depression.	serotonin	depression	1564030	-1
-CONCLUSION: Although the natural occurrence of YMDD motif mutants in lamivudine-untreated patients with chronic hepatitis B has been reported, these mutants were not detected in Iranian lamivudine-untreated chronic hepatitis B patients.	lamivudine	hepatitis B	17954033	-1
-CONCLUSION: Although the natural occurrence of YMDD motif mutants in lamivudine-untreated patients with chronic hepatitis B has been reported, these mutants were not detected in Iranian lamivudine-untreated chronic hepatitis B patients.	lamivudine	hepatitis B	17954033	-1
-CONCLUSION: Although the natural occurrence of YMDD motif mutants in lamivudine-untreated patients with chronic hepatitis B has been reported, these mutants were not detected in Iranian lamivudine-untreated chronic hepatitis B patients.	lamivudine	hepatitis B	17954033	-1
-CONCLUSION: Although the natural occurrence of YMDD motif mutants in lamivudine-untreated patients with chronic hepatitis B has been reported, these mutants were not detected in Iranian lamivudine-untreated chronic hepatitis B patients.	lamivudine	hepatitis B	17954033	-1
-We suggest that DHEA displays typical neuroleptic-like effects, and may be used in the treatment of schizophrenia.	DHEA	schizophrenia	24739405	-1
-Valproate-induced hyperammonemic encephalopathy is an uncommon but serious effect of valproate treatment.	Valproate	hyperammonemic encephalopathy	24665854	-1
-Valproate-induced hyperammonemic encephalopathy is an uncommon but serious effect of valproate treatment.	valproate	hyperammonemic encephalopathy	24665854	-1
-Coronary computerized tomography angiography for rapid discharge of low-risk patients with cocaine-associated chest pain.	cocaine	chest pain	19655282	1
-Lenalidomide and dexamethasone (RD) is a standard of care for relapsed/refractory multiple myeloma (RRMM), but there is limited published data on its efficacy and safety in the "real world" (RW), according to the International Society of Pharmacoeconomics and Outcomes Research definition.	dexamethasone	myeloma	23892921	-1
-Lenalidomide and dexamethasone (RD) is a standard of care for relapsed/refractory multiple myeloma (RRMM), but there is limited published data on its efficacy and safety in the "real world" (RW), according to the International Society of Pharmacoeconomics and Outcomes Research definition.	dexamethasone	RRMM	23892921	-1
-Lenalidomide and dexamethasone (RD) is a standard of care for relapsed/refractory multiple myeloma (RRMM), but there is limited published data on its efficacy and safety in the "real world" (RW), according to the International Society of Pharmacoeconomics and Outcomes Research definition.	Lenalidomide	myeloma	23892921	-1
-Lenalidomide and dexamethasone (RD) is a standard of care for relapsed/refractory multiple myeloma (RRMM), but there is limited published data on its efficacy and safety in the "real world" (RW), according to the International Society of Pharmacoeconomics and Outcomes Research definition.	Lenalidomide	RRMM	23892921	-1
-Three hours later the patient felt better, the frequency of PVC reduced to 4 - 5 x/minute and on the third day ECG was normal, potassium level was 3.34 meq/L. He was discharged on 7th day in good condition.	potassium	PVC	17297207	-1
-The results provide new insight into the potential role of ectopic hilar granule cells in the pilocarpine model of temporal lobe epilepsy.	pilocarpine	temporal lobe epilepsy	17042797	1
-In a 38-year-old male patient suffering from a severe postzosteric trigeminal neuralgia, intravenous application of 10 mg biperiden lactate led to a long-lasting paradoxical reaction characterized by considerable bradycardia, dysarthria, and dysphagia.	biperiden lactate	trigeminal neuralgia	2710809	-1
-In a 38-year-old male patient suffering from a severe postzosteric trigeminal neuralgia, intravenous application of 10 mg biperiden lactate led to a long-lasting paradoxical reaction characterized by considerable bradycardia, dysarthria, and dysphagia.	biperiden lactate	dysphagia	2710809	-1
-In a 38-year-old male patient suffering from a severe postzosteric trigeminal neuralgia, intravenous application of 10 mg biperiden lactate led to a long-lasting paradoxical reaction characterized by considerable bradycardia, dysarthria, and dysphagia.	biperiden lactate	dysarthria	2710809	-1
-In a 38-year-old male patient suffering from a severe postzosteric trigeminal neuralgia, intravenous application of 10 mg biperiden lactate led to a long-lasting paradoxical reaction characterized by considerable bradycardia, dysarthria, and dysphagia.	biperiden lactate	bradycardia	2710809	-1
-The present study aimed to evaluate the GFC effects at doses of 25, 50 or 75 mg/kg on seizure parameters to determine their anticonvulsant activity and its effects on amino acid (r-aminobutyric acid (GABA), glutamine, aspartate and glutathione) levels as well as on acetylcholinesterase (AChE) activity in mice hippocampus after seizures.	glutathione	seizure	24911645	-1
-The present study aimed to evaluate the GFC effects at doses of 25, 50 or 75 mg/kg on seizure parameters to determine their anticonvulsant activity and its effects on amino acid (r-aminobutyric acid (GABA), glutamine, aspartate and glutathione) levels as well as on acetylcholinesterase (AChE) activity in mice hippocampus after seizures.	glutathione	seizures	24911645	-1
-The present study aimed to evaluate the GFC effects at doses of 25, 50 or 75 mg/kg on seizure parameters to determine their anticonvulsant activity and its effects on amino acid (r-aminobutyric acid (GABA), glutamine, aspartate and glutathione) levels as well as on acetylcholinesterase (AChE) activity in mice hippocampus after seizures.	r-aminobutyric acid	seizure	24911645	-1
-The present study aimed to evaluate the GFC effects at doses of 25, 50 or 75 mg/kg on seizure parameters to determine their anticonvulsant activity and its effects on amino acid (r-aminobutyric acid (GABA), glutamine, aspartate and glutathione) levels as well as on acetylcholinesterase (AChE) activity in mice hippocampus after seizures.	r-aminobutyric acid	seizures	24911645	-1
-The present study aimed to evaluate the GFC effects at doses of 25, 50 or 75 mg/kg on seizure parameters to determine their anticonvulsant activity and its effects on amino acid (r-aminobutyric acid (GABA), glutamine, aspartate and glutathione) levels as well as on acetylcholinesterase (AChE) activity in mice hippocampus after seizures.	GABA	seizure	24911645	-1
-The present study aimed to evaluate the GFC effects at doses of 25, 50 or 75 mg/kg on seizure parameters to determine their anticonvulsant activity and its effects on amino acid (r-aminobutyric acid (GABA), glutamine, aspartate and glutathione) levels as well as on acetylcholinesterase (AChE) activity in mice hippocampus after seizures.	GABA	seizures	24911645	-1
-The present study aimed to evaluate the GFC effects at doses of 25, 50 or 75 mg/kg on seizure parameters to determine their anticonvulsant activity and its effects on amino acid (r-aminobutyric acid (GABA), glutamine, aspartate and glutathione) levels as well as on acetylcholinesterase (AChE) activity in mice hippocampus after seizures.	GFC	seizure	24911645	-1
-The present study aimed to evaluate the GFC effects at doses of 25, 50 or 75 mg/kg on seizure parameters to determine their anticonvulsant activity and its effects on amino acid (r-aminobutyric acid (GABA), glutamine, aspartate and glutathione) levels as well as on acetylcholinesterase (AChE) activity in mice hippocampus after seizures.	GFC	seizures	24911645	-1
-The present study aimed to evaluate the GFC effects at doses of 25, 50 or 75 mg/kg on seizure parameters to determine their anticonvulsant activity and its effects on amino acid (r-aminobutyric acid (GABA), glutamine, aspartate and glutathione) levels as well as on acetylcholinesterase (AChE) activity in mice hippocampus after seizures.	amino acid	seizure	24911645	-1
-The present study aimed to evaluate the GFC effects at doses of 25, 50 or 75 mg/kg on seizure parameters to determine their anticonvulsant activity and its effects on amino acid (r-aminobutyric acid (GABA), glutamine, aspartate and glutathione) levels as well as on acetylcholinesterase (AChE) activity in mice hippocampus after seizures.	amino acid	seizures	24911645	-1
-We report a case of a 76-year-old man with Waldenstrom macroglobulinaemia who suffered necrotising fasciitis without neutropenia after the combination treatment with bortezomib, high-dose dexamethasone and rituximab.	bortezomib	Waldenstrom macroglobulinaemia	24671324	-1
-We report a case of a 76-year-old man with Waldenstrom macroglobulinaemia who suffered necrotising fasciitis without neutropenia after the combination treatment with bortezomib, high-dose dexamethasone and rituximab.	bortezomib	neutropenia	24671324	-1
-We report a case of a 76-year-old man with Waldenstrom macroglobulinaemia who suffered necrotising fasciitis without neutropenia after the combination treatment with bortezomib, high-dose dexamethasone and rituximab.	bortezomib	necrotising fasciitis	24671324	-1
-We report a case of a 76-year-old man with Waldenstrom macroglobulinaemia who suffered necrotising fasciitis without neutropenia after the combination treatment with bortezomib, high-dose dexamethasone and rituximab.	dexamethasone	Waldenstrom macroglobulinaemia	24671324	-1
-We report a case of a 76-year-old man with Waldenstrom macroglobulinaemia who suffered necrotising fasciitis without neutropenia after the combination treatment with bortezomib, high-dose dexamethasone and rituximab.	dexamethasone	neutropenia	24671324	-1
-We report a case of a 76-year-old man with Waldenstrom macroglobulinaemia who suffered necrotising fasciitis without neutropenia after the combination treatment with bortezomib, high-dose dexamethasone and rituximab.	dexamethasone	necrotising fasciitis	24671324	-1
-Apart from this cytostatic effect, temsirolimus had an antiangiogenic effect with decrease of tumor microvessel density and of VEGF expression.	temsirolimus	tumor	20828385	-1
-Heart and liver patients had more infections than cyclosporine renal patients but fewer infections than the Aza renal patients.	cyclosporine	infections	6310832	1
-Heart and liver patients had more infections than cyclosporine renal patients but fewer infections than the Aza renal patients.	Aza	infections	6310832	1
-Levetiracetam as an adjunct to phenobarbital treatment in cats with suspected idiopathic epilepsy.	Levetiracetam	idiopathic epilepsy	18341442	-1
-Levetiracetam as an adjunct to phenobarbital treatment in cats with suspected idiopathic epilepsy.	phenobarbital	idiopathic epilepsy	18341442	-1
-CONCLUSIONS: These are the first data, to our knowledge, to show that treatment with any chelating agent can alleviate cognitive deficits due to Pb exposure.	Pb	cognitive deficits	17384765	-1
-A patient with renal disease developed Coombs-positive hemolytic anemia while receiving cephalothin therapy.	cephalothin	renal disease	816141	-1
-Amoxicillin-clavulanate stands out as the most common drug related to DILI.	Amoxicillin-clavulanate	DILI	16083708	-1
-METHODS: This is a cross-sectional study involving 95 patients with PD on uninterrupted levodopa therapy for at least 6 months.	levodopa	PD	23952588	-1
-According to Naranjo's algorithm the likelihood that our patient's agranulocytosis and thrombocytopenia occurred as a result of therapy with fluconazole is probable, with a total of six points.	fluconazole	agranulocytosis	24459006	1
-According to Naranjo's algorithm the likelihood that our patient's agranulocytosis and thrombocytopenia occurred as a result of therapy with fluconazole is probable, with a total of six points.	fluconazole	thrombocytopenia	24459006	1
-However, the oral dose of d,l-sotalol was significantly lower in patients with torsades de pointes (200 +/-	l-sotalol	torsades de pointes	9125676	1
-Administration of the dopamine precursor levodopa enhances learning in healthy subjects and stroke patients.	dopamine	stroke	16880771	-1
-Administration of the dopamine precursor levodopa enhances learning in healthy subjects and stroke patients.	levodopa	stroke	16880771	-1
-PURPOSE: Prenatal cocaine exposure has been linked with subependymal hemorrhage and the formation of cysts that are detectable on cranial sonography in neonates born at term.	cocaine	subependymal hemorrhage	11425091	-1
-We report the case of a female patient with rheumatoid arthritis who developed acute cytolytic hepatitis due to meloxicam.	meloxicam	rheumatoid arthritis	10427794	-1
-We report the case of a female patient with rheumatoid arthritis who developed acute cytolytic hepatitis due to meloxicam.	meloxicam	hepatitis	10427794	1
-CONCLUSION: The data suggest that fluocinolone acetonide implant (0.59 mg) helps to control inflammation in otherwise treatment-refractory cases of birdshot retinochoroidopathy.	fluocinolone acetonide	inflammation	24999722	-1
-CONCLUSION: The data suggest that fluocinolone acetonide implant (0.59 mg) helps to control inflammation in otherwise treatment-refractory cases of birdshot retinochoroidopathy.	fluocinolone acetonide	birdshot retinochoroidopathy	24999722	-1
-The dopamine agonist significantly impaired novel word learning compared to placebo.	dopamine	word learning	16880771	-1
-It was possible to suppress the increased ornithine decarboxylase activity with both beta-blockers in hypertrophied hearts, but there was no effect on the heart mass.	ornithine	hypertrophied	2974281	-1
-After the end of fenoterol-hydrobromide infusion, tremor amplitudes decreased significantly faster than those following ritodrin-HCl infusion.	ritodrin-HCl	tremor	689020	-1
-After the end of fenoterol-hydrobromide infusion, tremor amplitudes decreased significantly faster than those following ritodrin-HCl infusion.	fenoterol-hydrobromide	tremor	689020	1
-Our findings have implications for the provision of alcohol use interventions and psychological resources to improve the health of women with HIV.	alcohol	HIV	20024739	-1
-We report on the development of 8 serious cases of ischemic colitis in patients with migraine treated with sumatriptan.	sumatriptan	migraine	9759693	-1
-Factors associated with the development of fulminant hepatic failure were female sex (OR = 25; 95% CI: 4.1-151; P < .0001), hepatocellular damage (OR = 7.9; 95% CI: 1.6-37; P < .009), and higher baseline plasma bilirubin value (OR = 1.15; 95% CI: 1.09-1.22; P < .0001).	bilirubin	hepatocellular damage	16083708	-1
-Factors associated with the development of fulminant hepatic failure were female sex (OR = 25; 95% CI: 4.1-151; P < .0001), hepatocellular damage (OR = 7.9; 95% CI: 1.6-37; P < .009), and higher baseline plasma bilirubin value (OR = 1.15; 95% CI: 1.09-1.22; P < .0001).	bilirubin	fulminant hepatic failure	16083708	-1
-A case of acute hepatitis induced by zidovudine in a 38-year-old patient with AIDS is presented.	zidovudine	hepatitis	1556529	1
-A case of acute hepatitis induced by zidovudine in a 38-year-old patient with AIDS is presented.	zidovudine	AIDS	1556529	-1
-The association between tranexamic acid and convulsive seizures after cardiac surgery: a multivariate analysis in 11 529 patients.	tranexamic acid	convulsive seizures	24588023	1
-Simvastatin plasma concentration increased 30 times in this patient and statin induced muscle toxicity is related to the concentration of the statin in blood.	Simvastatin	muscle toxicity	24927617	-1
-Simvastatin plasma concentration increased 30 times in this patient and statin induced muscle toxicity is related to the concentration of the statin in blood.	statin	muscle toxicity	24927617	-1
-Simvastatin plasma concentration increased 30 times in this patient and statin induced muscle toxicity is related to the concentration of the statin in blood.	statin	muscle toxicity	24927617	-1
-Thus, phasic signaling seems to be the critical mechanism by which dopamine enhances associative learning in healthy subjects and stroke patients.	dopamine	stroke	16880771	-1
-Randomized clinical trials comparing VNR with other drugs in the treatment of cancer were searched in Medline, Embase, Evidence-based Medicine Reviews databases and the Cochrane library from 1987 to 2002.	VNR	cancer	14748761	-1
-Susceptibility to seizures produced by pilocarpine in rats after microinjection of isoniazid or gamma-vinyl-GABA into the substantia nigra.	gamma-vinyl-GABA	seizures	3708328	-1
-Susceptibility to seizures produced by pilocarpine in rats after microinjection of isoniazid or gamma-vinyl-GABA into the substantia nigra.	isoniazid	seizures	3708328	-1
-Susceptibility to seizures produced by pilocarpine in rats after microinjection of isoniazid or gamma-vinyl-GABA into the substantia nigra.	pilocarpine	seizures	3708328	1
-A 45-year-old male patient who was on treatment with multiple second-line anti-tuberculous drugs including linezolid and ethambutol for extensively drug-resistant tuberculosis (XDR-TB) presented to us with painless progressive loss of vision in both eyes.	XDR-TB	tuberculous	24088636	-1
-A 45-year-old male patient who was on treatment with multiple second-line anti-tuberculous drugs including linezolid and ethambutol for extensively drug-resistant tuberculosis (XDR-TB) presented to us with painless progressive loss of vision in both eyes.	XDR-TB	tuberculosis	24088636	-1
-A 45-year-old male patient who was on treatment with multiple second-line anti-tuberculous drugs including linezolid and ethambutol for extensively drug-resistant tuberculosis (XDR-TB) presented to us with painless progressive loss of vision in both eyes.	XDR-TB	painless progressive loss of vision	24088636	-1
-A 45-year-old male patient who was on treatment with multiple second-line anti-tuberculous drugs including linezolid and ethambutol for extensively drug-resistant tuberculosis (XDR-TB) presented to us with painless progressive loss of vision in both eyes.	linezolid	tuberculous	24088636	-1
-A 45-year-old male patient who was on treatment with multiple second-line anti-tuberculous drugs including linezolid and ethambutol for extensively drug-resistant tuberculosis (XDR-TB) presented to us with painless progressive loss of vision in both eyes.	linezolid	tuberculosis	24088636	-1
-A 45-year-old male patient who was on treatment with multiple second-line anti-tuberculous drugs including linezolid and ethambutol for extensively drug-resistant tuberculosis (XDR-TB) presented to us with painless progressive loss of vision in both eyes.	linezolid	painless progressive loss of vision	24088636	-1
-A 45-year-old male patient who was on treatment with multiple second-line anti-tuberculous drugs including linezolid and ethambutol for extensively drug-resistant tuberculosis (XDR-TB) presented to us with painless progressive loss of vision in both eyes.	ethambutol	tuberculous	24088636	-1
-A 45-year-old male patient who was on treatment with multiple second-line anti-tuberculous drugs including linezolid and ethambutol for extensively drug-resistant tuberculosis (XDR-TB) presented to us with painless progressive loss of vision in both eyes.	ethambutol	tuberculosis	24088636	-1
-A 45-year-old male patient who was on treatment with multiple second-line anti-tuberculous drugs including linezolid and ethambutol for extensively drug-resistant tuberculosis (XDR-TB) presented to us with painless progressive loss of vision in both eyes.	ethambutol	painless progressive loss of vision	24088636	-1
-Rats treated with 500 ppm quinacrine hydrochloride in the diet all developed a high incidence of left atrial thrombosis.	quinacrine hydrochloride	atrial thrombosis	6517710	-1
-Five cases of encephalitis during treatment of loiasis with diethylcarbamazine.	diethylcarbamazine	encephalitis	1858969	1
-Five cases of encephalitis during treatment of loiasis with diethylcarbamazine.	diethylcarbamazine	loiasis	1858969	-1
-Syncope caused by hyperkalemia during use of a combined therapy with the angiotensin-converting enzyme inhibitor and spironolactone.	angiotensin	hyperkalemia	20859899	-1
-Syncope caused by hyperkalemia during use of a combined therapy with the angiotensin-converting enzyme inhibitor and spironolactone.	angiotensin	Syncope	20859899	-1
-Syncope caused by hyperkalemia during use of a combined therapy with the angiotensin-converting enzyme inhibitor and spironolactone.	spironolactone	hyperkalemia	20859899	1
-Syncope caused by hyperkalemia during use of a combined therapy with the angiotensin-converting enzyme inhibitor and spironolactone.	spironolactone	Syncope	20859899	-1
-On the basis of the findings reported herein, a dose of 60 mg/m(2) of CCNU combined with 250 mg/m(2) of CTX (divided over 5 days) q 4 wk is tolerable in tumor-bearing dogs.	CCNU	tumor	24659727	-1
-On the basis of the findings reported herein, a dose of 60 mg/m(2) of CCNU combined with 250 mg/m(2) of CTX (divided over 5 days) q 4 wk is tolerable in tumor-bearing dogs.	CTX	tumor	24659727	-1
-The acute cytolytic hepatitis occurred rapidly after meloxicam administration and was associated with the development of antinuclear antibodies suggesting a hypersensitivity mechanism.	meloxicam	hepatitis	10427794	1
-The acute cytolytic hepatitis occurred rapidly after meloxicam administration and was associated with the development of antinuclear antibodies suggesting a hypersensitivity mechanism.	meloxicam	hypersensitivity	10427794	1
-Important untoward effects of heparin therapy including heparin-induced thrombocytopenia, heparin-associated osteoporosis, eosinophilia, skin reactions, allergic reactions other than thrombocytopenia and alopecia will be discussed in this article.	heparin	thrombocytopenia	9646784	1
-Important untoward effects of heparin therapy including heparin-induced thrombocytopenia, heparin-associated osteoporosis, eosinophilia, skin reactions, allergic reactions other than thrombocytopenia and alopecia will be discussed in this article.	heparin	osteoporosis	9646784	1
-Important untoward effects of heparin therapy including heparin-induced thrombocytopenia, heparin-associated osteoporosis, eosinophilia, skin reactions, allergic reactions other than thrombocytopenia and alopecia will be discussed in this article.	heparin	eosinophilia	9646784	1
-Important untoward effects of heparin therapy including heparin-induced thrombocytopenia, heparin-associated osteoporosis, eosinophilia, skin reactions, allergic reactions other than thrombocytopenia and alopecia will be discussed in this article.	heparin	allergic	9646784	1
-Important untoward effects of heparin therapy including heparin-induced thrombocytopenia, heparin-associated osteoporosis, eosinophilia, skin reactions, allergic reactions other than thrombocytopenia and alopecia will be discussed in this article.	heparin	alopecia	9646784	1
-Important untoward effects of heparin therapy including heparin-induced thrombocytopenia, heparin-associated osteoporosis, eosinophilia, skin reactions, allergic reactions other than thrombocytopenia and alopecia will be discussed in this article.	heparin	osteoporosis	9646784	1
-Important untoward effects of heparin therapy including heparin-induced thrombocytopenia, heparin-associated osteoporosis, eosinophilia, skin reactions, allergic reactions other than thrombocytopenia and alopecia will be discussed in this article.	heparin	thrombocytopenia	9646784	1
-Important untoward effects of heparin therapy including heparin-induced thrombocytopenia, heparin-associated osteoporosis, eosinophilia, skin reactions, allergic reactions other than thrombocytopenia and alopecia will be discussed in this article.	heparin	allergic	9646784	1
-Important untoward effects of heparin therapy including heparin-induced thrombocytopenia, heparin-associated osteoporosis, eosinophilia, skin reactions, allergic reactions other than thrombocytopenia and alopecia will be discussed in this article.	heparin	alopecia	9646784	1
-Important untoward effects of heparin therapy including heparin-induced thrombocytopenia, heparin-associated osteoporosis, eosinophilia, skin reactions, allergic reactions other than thrombocytopenia and alopecia will be discussed in this article.	heparin	eosinophilia	9646784	1
-An open-label phase II study of low-dose thalidomide in androgen-independent prostate cancer.	thalidomide	prostate cancer	12644816	-1
-Only five patients experienced blood disorders, one of whom was exposed to TMP-SMZ; of seven with erythema multiforme and Stevens-Johnson syndrome, four were exposed to TMP-SMZ.	TMP-SMZ	blood disorders	7479194	-1
-Only five patients experienced blood disorders, one of whom was exposed to TMP-SMZ; of seven with erythema multiforme and Stevens-Johnson syndrome, four were exposed to TMP-SMZ.	TMP-SMZ	erythema multiforme	7479194	-1
-Only five patients experienced blood disorders, one of whom was exposed to TMP-SMZ; of seven with erythema multiforme and Stevens-Johnson syndrome, four were exposed to TMP-SMZ.	TMP-SMZ	Stevens-Johnson syndrome	7479194	1
-Only five patients experienced blood disorders, one of whom was exposed to TMP-SMZ; of seven with erythema multiforme and Stevens-Johnson syndrome, four were exposed to TMP-SMZ.	TMP-SMZ	blood disorders	7479194	-1
-Only five patients experienced blood disorders, one of whom was exposed to TMP-SMZ; of seven with erythema multiforme and Stevens-Johnson syndrome, four were exposed to TMP-SMZ.	TMP-SMZ	erythema multiforme	7479194	-1
-The homozygous Gunn rats have unconjugated hyperbilirubinemia due to the absence of glucuronyl transferase, leading to marked bilirubin deposition in renal medulla and papilla.	glucuronyl	unconjugated hyperbilirubinemia	3864191	-1
-The homozygous Gunn rats have unconjugated hyperbilirubinemia due to the absence of glucuronyl transferase, leading to marked bilirubin deposition in renal medulla and papilla.	bilirubin	unconjugated hyperbilirubinemia	3864191	-1
-To the best of our knowledge this is the first ANCA positive carbimazole induced vasculitis case reported from India.	carbimazole	vasculitis	19263707	-1
-The antiangiogenic effects of thalidomide have been assessed in clinical trials in patients with various solid and haematological malignancies.	thalidomide	haematological malignancies	12644816	-1
-Dermal developmental toxicity of N-phenylimide herbicides in rats.	N-phenylimide herbicides	toxicity	24753331	-1
-The effects of a new inhaled antimuscarinic drug, oxitropium bromide, and of a slow-release theophylline preparation upon nocturnal asthma were compared in a placebo-controlled double-blind study.	theophylline	nocturnal asthma	3074291	-1
-The effects of a new inhaled antimuscarinic drug, oxitropium bromide, and of a slow-release theophylline preparation upon nocturnal asthma were compared in a placebo-controlled double-blind study.	oxitropium bromide	nocturnal asthma	3074291	-1
-This study prospectively evaluated the clinical efficacy, the incidence of torsades de pointes, and the presumable risk factors for torsades de pointes in patients treated with d,l-sotalol for sustained ventricular tachyarrhythmias.	l-sotalol	torsades de pointes	9125676	1
-This study prospectively evaluated the clinical efficacy, the incidence of torsades de pointes, and the presumable risk factors for torsades de pointes in patients treated with d,l-sotalol for sustained ventricular tachyarrhythmias.	l-sotalol	torsades de pointes	9125676	1
-This study prospectively evaluated the clinical efficacy, the incidence of torsades de pointes, and the presumable risk factors for torsades de pointes in patients treated with d,l-sotalol for sustained ventricular tachyarrhythmias.	l-sotalol	ventricular tachyarrhythmias	9125676	-1
-Verapamil stimulation test in hyperprolactinemia: loss of prolactin response in anatomic or functional stalk effect.	Verapamil	hyperprolactinemia	20595935	-1
-Morphological evaluation of the effect of d-ribose on adriamycin-evoked cardiotoxicity in rats.	d-ribose	cardiotoxicity	16092435	-1
-Morphological evaluation of the effect of d-ribose on adriamycin-evoked cardiotoxicity in rats.	adriamycin	cardiotoxicity	16092435	-1
-Utility of troponin I in patients with cocaine-associated chest pain.	cocaine	chest pain	12359538	-1
-The influence of d-ribose on adriamycin-induced myocardiopathy in rats was studied.	adriamycin	myocardiopathy	16092435	1
-In SHR but not in WKY administration of ANP, AVP and ANP + AVP decreased CCB during Phe-induced MAP elevation.	AVP	SHR	8188982	1
-In SHR but not in WKY administration of ANP, AVP and ANP + AVP decreased CCB during Phe-induced MAP elevation.	AVP	SHR	8188982	1
-In SHR but not in WKY administration of ANP, AVP and ANP + AVP decreased CCB during Phe-induced MAP elevation.	Phe	SHR	8188982	1
-In SHR but not in WKY administration of ANP, AVP and ANP + AVP decreased CCB during Phe-induced MAP elevation.	CCB	SHR	8188982	-1
-Adriamycin in the cumulative dose of 25 mg/kg evoked fully developed cardiac toxicity.	Adriamycin	cardiac toxicity	16092435	-1
-The average plasma lidocaine level 10 minutes after administration for patients without a myocardial infarction was significantly higher than that for patients with an acute infarction.	lidocaine	myocardial infarction	3895875	-1
-The average plasma lidocaine level 10 minutes after administration for patients without a myocardial infarction was significantly higher than that for patients with an acute infarction.	lidocaine	infarction	3895875	-1
-D-ribose in the multiple doses of 200 mg/kg did not influence ADR cardiotoxicity.	ADR	cardiotoxicity	16092435	-1
-D-ribose in the multiple doses of 200 mg/kg did not influence ADR cardiotoxicity.	D-ribose	cardiotoxicity	16092435	-1
-We examined the case of a lithium-treated patient who had recurrent hypercalcemia to better understand the disease process.	lithium	hypercalcemia	19154241	1
-On average, MA abusers had 7.8% smaller hippocampal volumes than control subjects (p < 0.01; left, p = 0.01; right, p < 0.05) and significant white-matter hypertrophy (7.0%; p < 0.01).	MA	white-matter hypertrophy	15229250	-1
-Procaterol, a new beta-2 adrenoceptor stimulant, was studied in a double-blind, placebo-controlled, cross-over trial in patients with bronchial asthma.	Procaterol	bronchial asthma	2933998	-1
-For PCI, argatroban has not been investigated in hepatically impaired patients; dose adjustment is unnecessary for adult age, sex, race/ethnicity or obesity, and lesser doses may be adequate with concurrent glycoprotein IIb/IIIa inhibition.	argatroban	obesity	19338378	-1
-Moreover, numerous patchy, well-limited fibrotic areas, compatible with post-necrotic tissue repair, were found after 6-month temsirolimus therapy.	temsirolimus	necrotic	20828385	1
-With 2-week chronic epinephrine infusion, 16 of 30 rats died within 4 days, and severe ischemic lesions and fibrosis of the left ventricles were observed.	epinephrine	ischemic lesions	8392553	-1
-With 2-week chronic epinephrine infusion, 16 of 30 rats died within 4 days, and severe ischemic lesions and fibrosis of the left ventricles were observed.	epinephrine	fibrosis	8392553	-1
-On day 8, the patient developed acute renal failure (serum creatinine 1.9 mg/dL, increased from 1.2 mg/dL the previous day and 0.8 mg/dL on admission).	creatinine	acute renal failure	20959502	-1
-Histological examination showed that losartan could prevent tubular atrophy, interstitial infiltration and fibrosis in ADR nephropathy.	ADR	tubular atrophy	18987260	-1
-Histological examination showed that losartan could prevent tubular atrophy, interstitial infiltration and fibrosis in ADR nephropathy.	ADR	fibrosis	18987260	-1
-Histological examination showed that losartan could prevent tubular atrophy, interstitial infiltration and fibrosis in ADR nephropathy.	ADR	nephropathy	18987260	-1
-Histological examination showed that losartan could prevent tubular atrophy, interstitial infiltration and fibrosis in ADR nephropathy.	losartan	tubular atrophy	18987260	-1
-Histological examination showed that losartan could prevent tubular atrophy, interstitial infiltration and fibrosis in ADR nephropathy.	losartan	fibrosis	18987260	-1
-Histological examination showed that losartan could prevent tubular atrophy, interstitial infiltration and fibrosis in ADR nephropathy.	losartan	nephropathy	18987260	-1
-One day after experimental myocardial infarction, six additional halothane-anesthetized dogs received 4 micrograms.kg-1.min-1 epinephrine until VT appeared.	epinephrine	myocardial infarction	8659767	-1
-One day after experimental myocardial infarction, six additional halothane-anesthetized dogs received 4 micrograms.kg-1.min-1 epinephrine until VT appeared.	epinephrine	VT	8659767	1
-One day after experimental myocardial infarction, six additional halothane-anesthetized dogs received 4 micrograms.kg-1.min-1 epinephrine until VT appeared.	halothane	myocardial infarction	8659767	-1
-One day after experimental myocardial infarction, six additional halothane-anesthetized dogs received 4 micrograms.kg-1.min-1 epinephrine until VT appeared.	halothane	VT	8659767	-1
-In this study, we retrospectively analyzed the safety and efficacy of combination regimen of bortezomib, thalidomide, and dexamethasone (VTD) as consolidation therapy in 24 Japanese patients with newly diagnosed MM.	bortezomib	MM	24928523	-1
-In this study, we retrospectively analyzed the safety and efficacy of combination regimen of bortezomib, thalidomide, and dexamethasone (VTD) as consolidation therapy in 24 Japanese patients with newly diagnosed MM.	dexamethasone	MM	24928523	-1
-In this study, we retrospectively analyzed the safety and efficacy of combination regimen of bortezomib, thalidomide, and dexamethasone (VTD) as consolidation therapy in 24 Japanese patients with newly diagnosed MM.	thalidomide	MM	24928523	-1
-High doses of inhaled salbutamol produce substantial improvements in airway response in patients with asthma, and are associated with dose-dependent systemic beta-adrenoceptor responses.	salbutamol	asthma	2782734	-1
-This case further supports the concern about thromboembolic complications associated with ATRA therapy in APL patients.	ATRA	thromboembolic	9158667	-1
-This case further supports the concern about thromboembolic complications associated with ATRA therapy in APL patients.	ATRA	APL	9158667	-1
-BACKGROUND: S-53482 and S-23121 are N-phenylimide herbicides and produced embryolethality, teratogenicity (mainly ventricular septal defects and wavy ribs), and growth retardation in rats in conventional oral developmental toxicity studies.	N-phenylimide herbicides	growth retardation	24753331	-1
-BACKGROUND: S-53482 and S-23121 are N-phenylimide herbicides and produced embryolethality, teratogenicity (mainly ventricular septal defects and wavy ribs), and growth retardation in rats in conventional oral developmental toxicity studies.	N-phenylimide herbicides	ventricular septal defects	24753331	-1
-BACKGROUND: S-53482 and S-23121 are N-phenylimide herbicides and produced embryolethality, teratogenicity (mainly ventricular septal defects and wavy ribs), and growth retardation in rats in conventional oral developmental toxicity studies.	N-phenylimide herbicides	toxicity	24753331	-1
-BACKGROUND: S-53482 and S-23121 are N-phenylimide herbicides and produced embryolethality, teratogenicity (mainly ventricular septal defects and wavy ribs), and growth retardation in rats in conventional oral developmental toxicity studies.	S-23121	toxicity	24753331	-1
-BACKGROUND: S-53482 and S-23121 are N-phenylimide herbicides and produced embryolethality, teratogenicity (mainly ventricular septal defects and wavy ribs), and growth retardation in rats in conventional oral developmental toxicity studies.	S-53482	growth retardation	24753331	1
-BACKGROUND: S-53482 and S-23121 are N-phenylimide herbicides and produced embryolethality, teratogenicity (mainly ventricular septal defects and wavy ribs), and growth retardation in rats in conventional oral developmental toxicity studies.	S-53482	ventricular septal defects	24753331	1
-BACKGROUND: S-53482 and S-23121 are N-phenylimide herbicides and produced embryolethality, teratogenicity (mainly ventricular septal defects and wavy ribs), and growth retardation in rats in conventional oral developmental toxicity studies.	S-53482	toxicity	24753331	-1
-Mefenamic acid-induced neutropenia and renal failure in elderly females with hypothyroidism.	Mefenamic acid	hypothyroidism	2217015	-1
-Mefenamic acid-induced neutropenia and renal failure in elderly females with hypothyroidism.	Mefenamic acid	neutropenia	2217015	1
-Mefenamic acid-induced neutropenia and renal failure in elderly females with hypothyroidism.	Mefenamic acid	renal failure	2217015	1
-Growth-associated protein 43 expression in hippocampal molecular layer of chronic epileptic rats treated with cycloheximide.	cycloheximide	epileptic	15987266	-1
-Furthermore, the pressor action of vasopressin appears to be important in the development of this model of hypertension, since the enhanced pressor responsiveness to the hormone was observed in the initial stage of hypertension.	vasopressin	hypertension	6321816	-1
-Furthermore, the pressor action of vasopressin appears to be important in the development of this model of hypertension, since the enhanced pressor responsiveness to the hormone was observed in the initial stage of hypertension.	vasopressin	hypertension	6321816	-1
-The incidence of neurotoxicity may be reduced by employing lower doses of methotrexate in the presence of central nervous system leukemia, in older children and adults, and in the presence of epidural leakage.	methotrexate	neurotoxicity	946593	-1
-The incidence of neurotoxicity may be reduced by employing lower doses of methotrexate in the presence of central nervous system leukemia, in older children and adults, and in the presence of epidural leakage.	methotrexate	leukemia	946593	-1
-Increased expression of neuronal nitric oxide synthase in bladder afferent pathways following chronic bladder irritation.	nitric oxide	bladder irritation	8808730	-1
-Oxidative stress is involved in several processes including cancer, aging and cardiovascular disease, and has been shown to potentiate the therapeutic effect of drugs such as doxorubicin.	doxorubicin	cancer	24727461	-1
-Oxidative stress is involved in several processes including cancer, aging and cardiovascular disease, and has been shown to potentiate the therapeutic effect of drugs such as doxorubicin.	doxorubicin	cardiovascular disease	24727461	-1
-Cardiovascular effects of hypotension induced by adenosine triphosphate and sodium nitroprusside on dogs with denervated hearts.	sodium	hypotension	7147232	-1
-Cardiovascular effects of hypotension induced by adenosine triphosphate and sodium nitroprusside on dogs with denervated hearts.	nitroprusside	hypotension	7147232	1
-Cardiovascular effects of hypotension induced by adenosine triphosphate and sodium nitroprusside on dogs with denervated hearts.	adenosine triphosphate	hypotension	7147232	1
-Chemical cystitis was induced by cyclophosphamide (CYP) which is metabolized to acrolein, an irritant eliminated in the urine.	CYP	cystitis	8808730	1
-Chemical cystitis was induced by cyclophosphamide (CYP) which is metabolized to acrolein, an irritant eliminated in the urine.	acrolein	cystitis	8808730	-1
-Also, BCNU administration increased serum tumor necrosis factor-alpha (TNFalpha), hippocampal MT and malondialdehyde (MDA) contents as well as caspase-3 activity in addition to histological alterations.	MT	tumor	20046642	-1
-Also, BCNU administration increased serum tumor necrosis factor-alpha (TNFalpha), hippocampal MT and malondialdehyde (MDA) contents as well as caspase-3 activity in addition to histological alterations.	MT	necrosis	20046642	-1
-Also, BCNU administration increased serum tumor necrosis factor-alpha (TNFalpha), hippocampal MT and malondialdehyde (MDA) contents as well as caspase-3 activity in addition to histological alterations.	TNFalpha	tumor	20046642	-1
-Also, BCNU administration increased serum tumor necrosis factor-alpha (TNFalpha), hippocampal MT and malondialdehyde (MDA) contents as well as caspase-3 activity in addition to histological alterations.	TNFalpha	necrosis	20046642	-1
-Also, BCNU administration increased serum tumor necrosis factor-alpha (TNFalpha), hippocampal MT and malondialdehyde (MDA) contents as well as caspase-3 activity in addition to histological alterations.	malondialdehyde	tumor	20046642	-1
-Also, BCNU administration increased serum tumor necrosis factor-alpha (TNFalpha), hippocampal MT and malondialdehyde (MDA) contents as well as caspase-3 activity in addition to histological alterations.	malondialdehyde	necrosis	20046642	-1
-Also, BCNU administration increased serum tumor necrosis factor-alpha (TNFalpha), hippocampal MT and malondialdehyde (MDA) contents as well as caspase-3 activity in addition to histological alterations.	MDA	tumor	20046642	-1
-Also, BCNU administration increased serum tumor necrosis factor-alpha (TNFalpha), hippocampal MT and malondialdehyde (MDA) contents as well as caspase-3 activity in addition to histological alterations.	MDA	necrosis	20046642	-1
-Also, BCNU administration increased serum tumor necrosis factor-alpha (TNFalpha), hippocampal MT and malondialdehyde (MDA) contents as well as caspase-3 activity in addition to histological alterations.	BCNU	tumor	20046642	-1
-Also, BCNU administration increased serum tumor necrosis factor-alpha (TNFalpha), hippocampal MT and malondialdehyde (MDA) contents as well as caspase-3 activity in addition to histological alterations.	BCNU	necrosis	20046642	-1
-Electrocardiographic changes after dipyridamole infusion (0.568 mg/kg/4 min) were studied in 41 patients with coronary artery disease and compared with those after submaximal treadmill exercise by use of the body surface mapping technique.	dipyridamole	coronary artery disease	3746148	-1
-However, it would seem prudent not to use mefenamic acid in hypothyroid patients until the hypothyroidism has been corrected.	mefenamic acid	hypothyroid	2217015	-1
-However, it would seem prudent not to use mefenamic acid in hypothyroid patients until the hypothyroidism has been corrected.	mefenamic acid	hypothyroidism	2217015	-1
-Famotidine is a histamine H2-receptor antagonist used in inpatient settings for prevention of stress ulcers and is showing increasing popularity because of its low cost.	histamine	ulcers	8701013	-1
-Famotidine is a histamine H2-receptor antagonist used in inpatient settings for prevention of stress ulcers and is showing increasing popularity because of its low cost.	Famotidine	ulcers	8701013	-1
-Three patients had acute viral myocarditis, one had a carbamazepine-induced acute eosinophilic myocarditis, and one had cardiac hemosiderosis resulting in acute cardiogenic shock.	carbamazepine	cardiac hemosiderosis	7739955	-1
-Three patients had acute viral myocarditis, one had a carbamazepine-induced acute eosinophilic myocarditis, and one had cardiac hemosiderosis resulting in acute cardiogenic shock.	carbamazepine	cardiogenic shock	7739955	-1
-Three patients had acute viral myocarditis, one had a carbamazepine-induced acute eosinophilic myocarditis, and one had cardiac hemosiderosis resulting in acute cardiogenic shock.	carbamazepine	viral myocarditis	7739955	1
-Three patients had acute viral myocarditis, one had a carbamazepine-induced acute eosinophilic myocarditis, and one had cardiac hemosiderosis resulting in acute cardiogenic shock.	carbamazepine	eosinophilic myocarditis	7739955	1
-Clinical evaluation of adverse effects during bepridil administration for atrial fibrillation and flutter.	bepridil	atrial fibrillation	16723784	-1
-Clinical evaluation of adverse effects during bepridil administration for atrial fibrillation and flutter.	bepridil	flutter	16723784	-1
-BACKGROUND: Bepridil hydrochloride (Bpd) has attracted attention as an effective drug for atrial fibrillation (AF) and atrial flutter (AFL).	Bepridil hydrochloride	atrial flutter	16723784	-1
-BACKGROUND: Bepridil hydrochloride (Bpd) has attracted attention as an effective drug for atrial fibrillation (AF) and atrial flutter (AFL).	Bepridil hydrochloride	AFL	16723784	-1
-BACKGROUND: Bepridil hydrochloride (Bpd) has attracted attention as an effective drug for atrial fibrillation (AF) and atrial flutter (AFL).	Bepridil hydrochloride	atrial fibrillation	16723784	-1
-BACKGROUND: Bepridil hydrochloride (Bpd) has attracted attention as an effective drug for atrial fibrillation (AF) and atrial flutter (AFL).	Bepridil hydrochloride	AF	16723784	-1
-BACKGROUND: Bepridil hydrochloride (Bpd) has attracted attention as an effective drug for atrial fibrillation (AF) and atrial flutter (AFL).	Bpd	atrial flutter	16723784	-1
-BACKGROUND: Bepridil hydrochloride (Bpd) has attracted attention as an effective drug for atrial fibrillation (AF) and atrial flutter (AFL).	Bpd	AFL	16723784	-1
-BACKGROUND: Bepridil hydrochloride (Bpd) has attracted attention as an effective drug for atrial fibrillation (AF) and atrial flutter (AFL).	Bpd	atrial fibrillation	16723784	-1
-BACKGROUND: Bepridil hydrochloride (Bpd) has attracted attention as an effective drug for atrial fibrillation (AF) and atrial flutter (AFL).	Bpd	AF	16723784	-1
-The age-related decrease in hypothalamic dopamine function may be associated with increases in PRL secretion.	dopamine	hypothalamic	9128918	-1
-Rhabdomyolysis in association with simvastatin and dosage increment in clarithromycin.	clarithromycin	Rhabdomyolysis	25041770	1
-CONCLUSIONS: Crocin may be considered as a novel protective agent in diazinon-induced hyperlipemia through modulating of ERK pathway and increase of LDLr expression.	diazinon	hyperlipemia	24132704	1
-CONCLUSIONS: Crocin may be considered as a novel protective agent in diazinon-induced hyperlipemia through modulating of ERK pathway and increase of LDLr expression.	Crocin	hyperlipemia	24132704	-1
-This particular case is of interest as rhabdomyolysis only occurred after an increase in the dose of clarithromycin.	clarithromycin	rhabdomyolysis	25041770	1
-Our findings showed that pubertal BPA exposure increased anxiety-like behavior, which may be associated with decreased AChE activity of the hippocampus in adult male mice.	BPA	anxiety	23871786	1
-In this work CCR2 and CCL2 expression were examined following status epilepticus (SE) induced by pilocarpine injection.	CCL2	status epilepticus	20034406	-1
-In this work CCR2 and CCL2 expression were examined following status epilepticus (SE) induced by pilocarpine injection.	CCL2	SE	20034406	-1
-Recurrent subarachnoid hemorrhage associated with aminocaproic acid therapy and acute renal artery thrombosis.	aminocaproic acid	acute renal artery thrombosis	448423	-1
-Recurrent subarachnoid hemorrhage associated with aminocaproic acid therapy and acute renal artery thrombosis.	aminocaproic acid	subarachnoid hemorrhage	448423	1
-In patients with atrial fibrillation digoxin is beneficial for ventricular rate control.	digoxin	atrial fibrillation	1449452	-1
-AIM: Verapamil stimulation test was previously investigated as a tool for differential diagnosis of hyperprolactinemia, but with conflicting results.	Verapamil	hyperprolactinemia	20595935	-1
-We recorded time to first dysrhythmia occurrence, respective times to 25% and 50% reduction of the heart rate (HR) and mean arterial pressure, and time to asystole and total amount of bupivacaine consumption.	bupivacaine	dysrhythmia	24438483	-1
-We recorded time to first dysrhythmia occurrence, respective times to 25% and 50% reduction of the heart rate (HR) and mean arterial pressure, and time to asystole and total amount of bupivacaine consumption.	bupivacaine	asystole	24438483	1
-Short CsA treatment presented slight or even absent kidney lesions and TGF-b, NF- kb, mTOR, PCNA, TP53, KIM-1, and CTGF as relevant gene and protein changes.	CsA	kidney lesions	24971338	1
-Short CsA treatment presented slight or even absent kidney lesions and TGF-b, NF- kb, mTOR, PCNA, TP53, KIM-1, and CTGF as relevant gene and protein changes.	TP53	kidney lesions	24971338	-1
-Autoradiographic evidence of estrogen binding sites in nuclei of diethylstilbesterol induced hamster renal carcinomas.	diethylstilbesterol	hamster renal carcinomas	2650911	-1
-Autoradiographic evidence of estrogen binding sites in nuclei of diethylstilbesterol induced hamster renal carcinomas.	estrogen	hamster renal carcinomas	2650911	-1
-Adenosine triphosphate (ATP) and sodium nitroprusside (SNP) are administered to patients to induce and control hypotension during anesthesia.	sodium nitroprusside	hypotension	7147232	1
-Adenosine triphosphate (ATP) and sodium nitroprusside (SNP) are administered to patients to induce and control hypotension during anesthesia.	SNP	hypotension	7147232	1
-Adenosine triphosphate (ATP) and sodium nitroprusside (SNP) are administered to patients to induce and control hypotension during anesthesia.	ATP	hypotension	7147232	1
-BACKGROUND: The purpose of this study was to compare surgical conditions, including the amount of intraoperative bleeding as well as intraoperative blood pressure, during functional endoscopic sinus surgery (FESS) using flexible reinforced laryngeal mask airway (FRLMA) versus endotracheal tube (ETT) in maintaining controlled hypotension anesthesia induced by propofol-remifentanil total i.v.	propofol-remifentanil	bleeding	19178808	-1
-Also, digoxin has undesirable effects such as increasing peripheral resistance and myocardial demands, and causing arrhythmias.	digoxin	arrhythmias	1449452	1
-Mice sensitive to the convulsant effects of nicotine had greater alpha-bungarotoxin binding in the hippocampus than seizure insensitive mice.	nicotine	seizure	4010471	1
-Mice sensitive to the convulsant effects of nicotine had greater alpha-bungarotoxin binding in the hippocampus than seizure insensitive mice.	alpha-bungarotoxin	seizure	4010471	-1
-To investigate how GAP43 expression (GAP43-ir) correlates with MFS, we assessed the intensity (densitometry) and extension (width) of GAP43-ir in the inner molecular layer of the dentate gyrus (IML) of rats subject to status epilepticus induced by pilocarpine (Pilo), previously injected or not with cycloheximide (CHX), which has been shown to inhibit MFS.	pilocarpine	status epilepticus	15987266	1
-To investigate how GAP43 expression (GAP43-ir) correlates with MFS, we assessed the intensity (densitometry) and extension (width) of GAP43-ir in the inner molecular layer of the dentate gyrus (IML) of rats subject to status epilepticus induced by pilocarpine (Pilo), previously injected or not with cycloheximide (CHX), which has been shown to inhibit MFS.	Pilo	status epilepticus	15987266	1
-To investigate how GAP43 expression (GAP43-ir) correlates with MFS, we assessed the intensity (densitometry) and extension (width) of GAP43-ir in the inner molecular layer of the dentate gyrus (IML) of rats subject to status epilepticus induced by pilocarpine (Pilo), previously injected or not with cycloheximide (CHX), which has been shown to inhibit MFS.	cycloheximide	status epilepticus	15987266	-1
-To investigate how GAP43 expression (GAP43-ir) correlates with MFS, we assessed the intensity (densitometry) and extension (width) of GAP43-ir in the inner molecular layer of the dentate gyrus (IML) of rats subject to status epilepticus induced by pilocarpine (Pilo), previously injected or not with cycloheximide (CHX), which has been shown to inhibit MFS.	CHX	status epilepticus	15987266	-1
-Bradycardia induced by biperiden is attributed to the speed of injection and to a dose-related dual effect of atropine-like drugs on muscarine receptors.	muscarine	Bradycardia	2710809	-1
-Bradycardia induced by biperiden is attributed to the speed of injection and to a dose-related dual effect of atropine-like drugs on muscarine receptors.	atropine	Bradycardia	2710809	-1
-People aged over 75 in atrial fibrillation on warfarin: the rate of major hemorrhage and stroke in more than 500 patient-years of follow-up.	warfarin	atrial fibrillation	15817013	-1
-People aged over 75 in atrial fibrillation on warfarin: the rate of major hemorrhage and stroke in more than 500 patient-years of follow-up.	warfarin	hemorrhage	15817013	1
-People aged over 75 in atrial fibrillation on warfarin: the rate of major hemorrhage and stroke in more than 500 patient-years of follow-up.	warfarin	stroke	15817013	-1
-This is the first reported patient with neuroleptic malignant syndrome probably caused by methylphenidate.	methylphenidate	neuroleptic malignant syndrome	9831002	1
-It is concluded that anticholinesterases are only partially effective in restoring neuromuscular function in succinylcholine apnoea despite muscle twitch activity typical of phase II block.	succinylcholine	apnoea	6627074	1
-Factors contributing to ribavirin-induced anemia. BACKGROUND AND AIM: Interferon and ribavirin combination therapy for chronic hepatitis C produces hemolytic anemia.	ribavirin	anemia	15482540	-1
-Factors contributing to ribavirin-induced anemia. BACKGROUND AND AIM: Interferon and ribavirin combination therapy for chronic hepatitis C produces hemolytic anemia.	ribavirin	chronic hepatitis C	15482540	-1
-Factors contributing to ribavirin-induced anemia. BACKGROUND AND AIM: Interferon and ribavirin combination therapy for chronic hepatitis C produces hemolytic anemia.	ribavirin	hemolytic anemia	15482540	1
-Factors contributing to ribavirin-induced anemia. BACKGROUND AND AIM: Interferon and ribavirin combination therapy for chronic hepatitis C produces hemolytic anemia.	ribavirin	anemia	15482540	-1
-Factors contributing to ribavirin-induced anemia. BACKGROUND AND AIM: Interferon and ribavirin combination therapy for chronic hepatitis C produces hemolytic anemia.	ribavirin	chronic hepatitis C	15482540	-1
-Factors contributing to ribavirin-induced anemia. BACKGROUND AND AIM: Interferon and ribavirin combination therapy for chronic hepatitis C produces hemolytic anemia.	Interferon	anemia	15482540	-1
-Factors contributing to ribavirin-induced anemia. BACKGROUND AND AIM: Interferon and ribavirin combination therapy for chronic hepatitis C produces hemolytic anemia.	Interferon	chronic hepatitis C	15482540	-1
-Factors contributing to ribavirin-induced anemia. BACKGROUND AND AIM: Interferon and ribavirin combination therapy for chronic hepatitis C produces hemolytic anemia.	Interferon	hemolytic anemia	15482540	-1
-CONCLUSION: Primary hyperparathyroidism is a rare but potentially life-threatening side effect of long-term lithium therapy.	lithium	Primary hyperparathyroidism	19154241	-1
-In the current study, dyskinetic patients performed better in swallowing function, which could be explained on the basis of a greater levodopa dose.	levodopa	dyskinetic	15625689	1
-Two well-documented cases of bilateral retinal artery and choriocapillaris occlusions with blindness following head and neck soft-tissue injection with methylprednisolone acetate in combination with lidocaine, epinephrine, or penicillin are reported.	penicillin	blindness	733189	-1
-Two well-documented cases of bilateral retinal artery and choriocapillaris occlusions with blindness following head and neck soft-tissue injection with methylprednisolone acetate in combination with lidocaine, epinephrine, or penicillin are reported.	penicillin	retinal artery	733189	-1
-Two well-documented cases of bilateral retinal artery and choriocapillaris occlusions with blindness following head and neck soft-tissue injection with methylprednisolone acetate in combination with lidocaine, epinephrine, or penicillin are reported.	epinephrine	blindness	733189	-1
-Two well-documented cases of bilateral retinal artery and choriocapillaris occlusions with blindness following head and neck soft-tissue injection with methylprednisolone acetate in combination with lidocaine, epinephrine, or penicillin are reported.	epinephrine	retinal artery	733189	-1
-Two well-documented cases of bilateral retinal artery and choriocapillaris occlusions with blindness following head and neck soft-tissue injection with methylprednisolone acetate in combination with lidocaine, epinephrine, or penicillin are reported.	lidocaine	blindness	733189	-1
-Two well-documented cases of bilateral retinal artery and choriocapillaris occlusions with blindness following head and neck soft-tissue injection with methylprednisolone acetate in combination with lidocaine, epinephrine, or penicillin are reported.	lidocaine	retinal artery	733189	-1
-Two well-documented cases of bilateral retinal artery and choriocapillaris occlusions with blindness following head and neck soft-tissue injection with methylprednisolone acetate in combination with lidocaine, epinephrine, or penicillin are reported.	methylprednisolone acetate	blindness	733189	-1
-To overcome the adverse effects of neutropenia, tobramycin was given by continuous infusion and combined with intermittent carbenicillin.	carbenicillin	neutropenia	256433	-1
-To overcome the adverse effects of neutropenia, tobramycin was given by continuous infusion and combined with intermittent carbenicillin.	tobramycin	neutropenia	256433	-1
-Acute treatment with metformin has a protective effect in myocardial infarction by suppression of inflammatory responses due to activation of AMP-activated protein kinase (AMPK).	metformin	myocardial infarction	24842192	-1
-Acute treatment with metformin has a protective effect in myocardial infarction by suppression of inflammatory responses due to activation of AMP-activated protein kinase (AMPK).	AMP	myocardial infarction	24842192	-1
-Acute treatment with metformin has a protective effect in myocardial infarction by suppression of inflammatory responses due to activation of AMP-activated protein kinase (AMPK).	AMPK	myocardial infarction	24842192	-1
-In ethacrynic acid-induced convulsions, these neurotransmitter systems may be differentially modulated, probably through activation of glutaminergic neurons in the brain.	ethacrynic acid	convulsions	1360900	1
-Increased anxiogenic effects of caffeine in panic disorders.	caffeine	panic disorders	2983630	-1
-Pituitary response to luteinizing hormone-releasing hormone during haloperidol-induced hyperprolactinemia.	haloperidol	hyperprolactinemia	7018927	1
-Heparin-induced thrombocytopenia, paradoxical thromboembolism, and other side effects of heparin therapy.	heparin	thrombocytopenia	9646784	1
-Heparin-induced thrombocytopenia, paradoxical thromboembolism, and other side effects of heparin therapy.	heparin	thromboembolism	9646784	1
-Animal model of mania induced by ouabain: Evidence of oxidative stress in submitochondrial particles of the rat brain.	ouabain	mania	19447152	1
-Doxorubicin causes significant cardiotoxicity characterized by marked increases in oxidative stress and mitochondrial dysfunction.	Doxorubicin	cardiotoxicity	24727461	-1
-Doxorubicin causes significant cardiotoxicity characterized by marked increases in oxidative stress and mitochondrial dysfunction.	Doxorubicin	mitochondrial dysfunction	24727461	-1
-Neurocognitive and neuroradiologic central nervous system late effects in children treated on Pediatric Oncology Group (POG) P9605 (standard risk) and P9201 (lesser risk) acute lymphoblastic leukemia protocols (ACCL0131): a methotrexate consequence?	methotrexate	acute lymphoblastic leukemia	24345882	-1
-At the end of each 14-day treatment, a dose-response curve (DRC) was performed, and airway (FEV1, FEF25-75) chronotropic (HR), tremor, and metabolic (K, Glu) responses were measured at each step (from 100 to 4,000 micrograms).	K	tremor	2782734	-1
-Despite concerns of fatal bone marrow toxicity due to carbamazepine, this is only the fourth documented and published report.	carbamazepine	bone marrow toxicity	3409843	-1
-It was hypothesized that progestins could equilibrate the effects of the estrogenic stimulation on the mammary and endometrial target tissues of women on hormonal replacement therapy.	progestins	endometrial	6305660	-1
-Encephalopathy during amitriptyline therapy: are neuroleptic malignant syndrome and serotonin syndrome spectrum disorders?	amitriptyline	Encephalopathy	8748050	1
-Encephalopathy during amitriptyline therapy: are neuroleptic malignant syndrome and serotonin syndrome spectrum disorders?	amitriptyline	neuroleptic malignant syndrome	8748050	-1
-Encephalopathy during amitriptyline therapy: are neuroleptic malignant syndrome and serotonin syndrome spectrum disorders?	amitriptyline	syndrome spectrum disorders	8748050	-1
-Encephalopathy during amitriptyline therapy: are neuroleptic malignant syndrome and serotonin syndrome spectrum disorders?	serotonin	Encephalopathy	8748050	-1
-Encephalopathy during amitriptyline therapy: are neuroleptic malignant syndrome and serotonin syndrome spectrum disorders?	serotonin	neuroleptic malignant syndrome	8748050	-1
-Encephalopathy during amitriptyline therapy: are neuroleptic malignant syndrome and serotonin syndrome spectrum disorders?	serotonin	syndrome spectrum disorders	8748050	-1
-Prevention of etomidate-induced myoclonus: which is superior: Fentanyl, midazolam, or a combination?	midazolam	myoclonus	24535067	-1
-Prevention of etomidate-induced myoclonus: which is superior: Fentanyl, midazolam, or a combination?	etomidate	myoclonus	24535067	1
-Prevention of etomidate-induced myoclonus: which is superior: Fentanyl, midazolam, or a combination?	Fentanyl	myoclonus	24535067	-1
-Both dronedarone and amiodarone significantly reduced the exercise-induced tachycardia and, at the highest dose, decreased the isoproterenol-induced tachycardia.	amiodarone	tachycardia	10975596	-1
-Both dronedarone and amiodarone significantly reduced the exercise-induced tachycardia and, at the highest dose, decreased the isoproterenol-induced tachycardia.	amiodarone	tachycardia	10975596	-1
-Both dronedarone and amiodarone significantly reduced the exercise-induced tachycardia and, at the highest dose, decreased the isoproterenol-induced tachycardia.	dronedarone	tachycardia	10975596	-1
-Both dronedarone and amiodarone significantly reduced the exercise-induced tachycardia and, at the highest dose, decreased the isoproterenol-induced tachycardia.	dronedarone	tachycardia	10975596	-1
-Both dronedarone and amiodarone significantly reduced the exercise-induced tachycardia and, at the highest dose, decreased the isoproterenol-induced tachycardia.	isoproterenol	tachycardia	10975596	1
-Here, we report a case of prolonged neuromuscular block after administration of suxamethonium leading to the discovery of a novel BCHE variant (c.695T>A, p.	suxamethonium	neuromuscular block	25054547	-1
-Therefore, the BNPP-induced reduction in APAP-induced nephrotoxicity appears to be due to inhibition of APAP deacetylation.	BNPP	nephrotoxicity	4082192	-1
-Therefore, the BNPP-induced reduction in APAP-induced nephrotoxicity appears to be due to inhibition of APAP deacetylation.	APAP	nephrotoxicity	4082192	-1
-Therefore, the BNPP-induced reduction in APAP-induced nephrotoxicity appears to be due to inhibition of APAP deacetylation.	APAP	nephrotoxicity	4082192	-1
-Lamivudine is effective in suppressing hepatitis B virus DNA in Chinese hepatitis B surface antigen carriers: a placebo-controlled trial.	Lamivudine	hepatitis B	8985298	-1
-The case of an 11-year-old boy is reported who was known to have Fanconi's anemia for 3 years and was treated with androgens, corticosteroids and transfusions.	corticosteroids	Fanconi's anemia	1655018	-1
-The case of an 11-year-old boy is reported who was known to have Fanconi's anemia for 3 years and was treated with androgens, corticosteroids and transfusions.	androgens	Fanconi's anemia	1655018	-1
-This case contributes to the previous observations that non-metastasizing hepatic neoplasms and peliosis can develop in patients with androgen- and corticosteroid-treated Fanconi's anemia.	corticosteroid	hepatic neoplasms	1655018	-1
-This case contributes to the previous observations that non-metastasizing hepatic neoplasms and peliosis can develop in patients with androgen- and corticosteroid-treated Fanconi's anemia.	corticosteroid	Fanconi's anemia	1655018	-1
-Fluoxetine improves the memory deficits caused by the chemotherapy agent 5-fluorouracil.	Fluoxetine	memory deficits	19914299	-1
-Fluoxetine improves the memory deficits caused by the chemotherapy agent 5-fluorouracil.	5-fluorouracil	memory deficits	19914299	1
-Moreover, 0.05 mg/kg of this beta-carboline reduced markedly the increase of [35S]TBPS binding and the convulsions induced by isoniazid (200 mg/kg s.c.).(ABSTRACT TRUNCATED AT 250 WORDS)	carboline	convulsions	1361574	-1
-The administration of L-arginine (600, 800 and 1000 mg/kg, i.p.) in dose-dependent manner significantly increased convulsion incidence and severity and shortened latency time to first convulsion elicited by lower lindane dose (4 mg/kg, i.p.).	lindane	convulsion	21195121	1
-METHODS: SE was induced by pilocarpine injection.	pilocarpine	SE	20034406	1
-Intradermal injections of glutamate and capsaicin are attractive to use in human experimental pain models because hyperalgesia and allodynia mimic isolated aspects of clinical pain disorders.	capsaicin	pain	24684312	-1
-Intradermal injections of glutamate and capsaicin are attractive to use in human experimental pain models because hyperalgesia and allodynia mimic isolated aspects of clinical pain disorders.	capsaicin	pain disorders	24684312	-1
-Intradermal injections of glutamate and capsaicin are attractive to use in human experimental pain models because hyperalgesia and allodynia mimic isolated aspects of clinical pain disorders.	capsaicin	hyperalgesia	24684312	1
-Intradermal injections of glutamate and capsaicin are attractive to use in human experimental pain models because hyperalgesia and allodynia mimic isolated aspects of clinical pain disorders.	capsaicin	allodynia	24684312	1
-The randomized Aza patients had more overall infections (P less than 0.05) and more nonviral infections (P less than 0.02) than the randomized cyclosporine patients.	cyclosporine	infections	6310832	1
-The randomized Aza patients had more overall infections (P less than 0.05) and more nonviral infections (P less than 0.02) than the randomized cyclosporine patients.	cyclosporine	infections	6310832	1
-The randomized Aza patients had more overall infections (P less than 0.05) and more nonviral infections (P less than 0.02) than the randomized cyclosporine patients.	Aza	infections	6310832	1
-These results support the conclusion that NO plays a role of endogenous convulsant in rat model of lindane seizures.	lindane	seizures	21195121	1
-These results support the conclusion that NO plays a role of endogenous convulsant in rat model of lindane seizures.	NO	seizures	21195121	-1
-Induction of the ventricular tachyarrhythmia was prevented by oral d,l-sotalol in 35 (43%) patients; the ventricular tachyarrhythmia remained inducible in 40 (49%) patients; and two (2.5%) patients did not tolerate even 40 mg of d,l-sotalol once daily.	l-sotalol	ventricular tachyarrhythmia	9125676	-1
-Induction of the ventricular tachyarrhythmia was prevented by oral d,l-sotalol in 35 (43%) patients; the ventricular tachyarrhythmia remained inducible in 40 (49%) patients; and two (2.5%) patients did not tolerate even 40 mg of d,l-sotalol once daily.	l-sotalol	ventricular tachyarrhythmia	9125676	-1
-Induction of the ventricular tachyarrhythmia was prevented by oral d,l-sotalol in 35 (43%) patients; the ventricular tachyarrhythmia remained inducible in 40 (49%) patients; and two (2.5%) patients did not tolerate even 40 mg of d,l-sotalol once daily.	l-sotalol	ventricular tachyarrhythmia	9125676	-1
-Induction of the ventricular tachyarrhythmia was prevented by oral d,l-sotalol in 35 (43%) patients; the ventricular tachyarrhythmia remained inducible in 40 (49%) patients; and two (2.5%) patients did not tolerate even 40 mg of d,l-sotalol once daily.	l-sotalol	ventricular tachyarrhythmia	9125676	-1
-Our findings demonstrated that ouabain at 10(-2) and 10(-3)M induced hyperlocomotion in rats, and this response remained up to 7 days following a single ICV injection.	ouabain	hyperlocomotion	19447152	-1
-The association of the tumor with preexisting hydroureteronephrosis suggests that stasis prolonged and intensified exposure of upper urinary tract epithelium to cyclophosphamide.	cyclophosphamide	tumor	7248895	-1
-BACKGROUND: The use of appetite suppressants in Europe has been associated with the development of primary pulmonary hypertension (PPH).	appetite suppressants	primary pulmonary hypertension	10713017	-1
-BACKGROUND: The use of appetite suppressants in Europe has been associated with the development of primary pulmonary hypertension (PPH).	appetite suppressants	PPH	10713017	-1
-Prolonged CsA exposure aggravated renal damage, without clear changes on the traditional markers, but with changes in serums TGF- b and IL-7, TBARs clearance, and kidney TGF-b and mTOR.	TBARs	renal damage	24971338	-1
-Our data suggested that the ginsenoside Re, but not Rg1 or Rb1, may contribute toward reversal of OIH.	Rg1	OIH	24709919	-1
-Our data suggested that the ginsenoside Re, but not Rg1 or Rb1, may contribute toward reversal of OIH.	ginsenoside Re	OIH	24709919	-1
-Oxyhemoglobin did not affect helodermin-induced hypotension, whereas it shortened the duration of acetylcholine (ACh)-produced hypotension.	ACh)-produced	hypotension	9881641	1
-Oxyhemoglobin did not affect helodermin-induced hypotension, whereas it shortened the duration of acetylcholine (ACh)-produced hypotension.	ACh)-produced	hypotension	9881641	1
-RESULTS: Trazodone at 2.5-20 mg/kg i.p. did not induce catalepsy, and did not antagonize apomorphine (1.5 and 3 mg/kg) stereotypy and apomorphine (0.05 mg/kg)-induced catalepsy.	Trazodone	catalepsy	15614572	-1
-RESULTS: Trazodone at 2.5-20 mg/kg i.p. did not induce catalepsy, and did not antagonize apomorphine (1.5 and 3 mg/kg) stereotypy and apomorphine (0.05 mg/kg)-induced catalepsy.	Trazodone	catalepsy	15614572	-1
-RESULTS: Trazodone at 2.5-20 mg/kg i.p. did not induce catalepsy, and did not antagonize apomorphine (1.5 and 3 mg/kg) stereotypy and apomorphine (0.05 mg/kg)-induced catalepsy.	apomorphine	catalepsy	15614572	1
-RESULTS: Trazodone at 2.5-20 mg/kg i.p. did not induce catalepsy, and did not antagonize apomorphine (1.5 and 3 mg/kg) stereotypy and apomorphine (0.05 mg/kg)-induced catalepsy.	apomorphine	catalepsy	15614572	1
-RESULTS: Trazodone at 2.5-20 mg/kg i.p. did not induce catalepsy, and did not antagonize apomorphine (1.5 and 3 mg/kg) stereotypy and apomorphine (0.05 mg/kg)-induced catalepsy.	apomorphine	catalepsy	15614572	1
-RESULTS: Trazodone at 2.5-20 mg/kg i.p. did not induce catalepsy, and did not antagonize apomorphine (1.5 and 3 mg/kg) stereotypy and apomorphine (0.05 mg/kg)-induced catalepsy.	apomorphine	catalepsy	15614572	1
-The binding sites from seizure sensitive and resistant mice were equally affected by treatment with dithiothreitol, trypsin or heat.	dithiothreitol	seizure	4010471	-1
-The binding sites from seizure sensitive and resistant mice were equally affected by treatment with dithiothreitol, trypsin or heat.	trypsin	seizure	4010471	-1
-Acute toxicity studies of ACC-9653 and phenytoin sodium were carried out in mice, rats, rabbits, and dogs by i.v.	ACC-9653	toxicity	2767010	-1
-Acute toxicity studies of ACC-9653 and phenytoin sodium were carried out in mice, rats, rabbits, and dogs by i.v.	phenytoin sodium	toxicity	2767010	-1
-For example, the symptoms of RLS can be dramatically improved by levodopa and dopamine agonists, whereas central dopamine D2 receptor antagonists can induce or aggravate RLS symptoms.	dopamine	RLS	16309808	-1
-For example, the symptoms of RLS can be dramatically improved by levodopa and dopamine agonists, whereas central dopamine D2 receptor antagonists can induce or aggravate RLS symptoms.	dopamine	RLS	16309808	-1
-For example, the symptoms of RLS can be dramatically improved by levodopa and dopamine agonists, whereas central dopamine D2 receptor antagonists can induce or aggravate RLS symptoms.	dopamine	RLS	16309808	-1
-For example, the symptoms of RLS can be dramatically improved by levodopa and dopamine agonists, whereas central dopamine D2 receptor antagonists can induce or aggravate RLS symptoms.	dopamine	RLS	16309808	-1
-For example, the symptoms of RLS can be dramatically improved by levodopa and dopamine agonists, whereas central dopamine D2 receptor antagonists can induce or aggravate RLS symptoms.	levodopa	RLS	16309808	-1
-For example, the symptoms of RLS can be dramatically improved by levodopa and dopamine agonists, whereas central dopamine D2 receptor antagonists can induce or aggravate RLS symptoms.	levodopa	RLS	16309808	-1
-Medical and psychiatric outcomes for patients transplanted for acetaminophen-induced acute liver failure: a case-control study.	acetaminophen	psychiatric	20408947	-1
-Medical and psychiatric outcomes for patients transplanted for acetaminophen-induced acute liver failure: a case-control study.	acetaminophen	acute liver failure	20408947	1
-Cocaine, ethanol, and cocaethylene cardiotoxity in an animal model of cocaine and ethanol abuse.	Cocaine	cocaethylene cardiotoxity	11229942	-1
-Cocaine, ethanol, and cocaethylene cardiotoxity in an animal model of cocaine and ethanol abuse.	cocaine	cocaethylene cardiotoxity	11229942	-1
-Cocaine, ethanol, and cocaethylene cardiotoxity in an animal model of cocaine and ethanol abuse.	ethanol	cocaethylene cardiotoxity	11229942	-1
-Cocaine, ethanol, and cocaethylene cardiotoxity in an animal model of cocaine and ethanol abuse.	ethanol	cocaethylene cardiotoxity	11229942	-1
-Amiodarone-related pulmonary mass and unique membranous glomerulonephritis in a patient with valvular heart disease: Diagnostic pitfall and new findings.	Amiodarone	valvular heart disease	18801087	-1
-The influence of the time interval between monoHER and doxorubicin administration on the protection against doxorubicin-induced cardiotoxicity in mice.	doxorubicin	cardiotoxicity	16565833	-1
-The influence of the time interval between monoHER and doxorubicin administration on the protection against doxorubicin-induced cardiotoxicity in mice.	doxorubicin	cardiotoxicity	16565833	-1
-Alfentanil 50 micrograms kg-1 effectively inhibits the incidence and intensity of suxamethonium-induced muscle fasciculations; moreover, intragastric pressure remains at its control value.	Alfentanil	muscle fasciculations	3125850	-1
-Alfentanil 50 micrograms kg-1 effectively inhibits the incidence and intensity of suxamethonium-induced muscle fasciculations; moreover, intragastric pressure remains at its control value.	suxamethonium	muscle fasciculations	3125850	1
-Five hundred seventy-nine patients were studied, 205 with PPH and 374 with pulmonary hypertension from other causes (secondary pulmonary hypertension [SPH]).	PPH	pulmonary hypertension	10713017	-1
-Five hundred seventy-nine patients were studied, 205 with PPH and 374 with pulmonary hypertension from other causes (secondary pulmonary hypertension [SPH]).	PPH	pulmonary hypertension	10713017	-1
-The effects of oral administration of caffeine (10 mg/kg) on behavioral ratings, somatic symptoms, blood pressure and plasma levels of 3-methoxy-4-hydroxyphenethyleneglycol (MHPG) and cortisol were determined in 17 healthy subjects and 21 patients meeting DSM-III criteria for agoraphobia with panic attacks or panic disorder.	3-methoxy-4-hydroxyphenethyleneglycol	agoraphobia	2983630	-1
-The effects of oral administration of caffeine (10 mg/kg) on behavioral ratings, somatic symptoms, blood pressure and plasma levels of 3-methoxy-4-hydroxyphenethyleneglycol (MHPG) and cortisol were determined in 17 healthy subjects and 21 patients meeting DSM-III criteria for agoraphobia with panic attacks or panic disorder.	3-methoxy-4-hydroxyphenethyleneglycol	panic attacks	2983630	-1
-The effects of oral administration of caffeine (10 mg/kg) on behavioral ratings, somatic symptoms, blood pressure and plasma levels of 3-methoxy-4-hydroxyphenethyleneglycol (MHPG) and cortisol were determined in 17 healthy subjects and 21 patients meeting DSM-III criteria for agoraphobia with panic attacks or panic disorder.	3-methoxy-4-hydroxyphenethyleneglycol	panic disorder	2983630	-1
-The effects of oral administration of caffeine (10 mg/kg) on behavioral ratings, somatic symptoms, blood pressure and plasma levels of 3-methoxy-4-hydroxyphenethyleneglycol (MHPG) and cortisol were determined in 17 healthy subjects and 21 patients meeting DSM-III criteria for agoraphobia with panic attacks or panic disorder.	MHPG	agoraphobia	2983630	-1
-The effects of oral administration of caffeine (10 mg/kg) on behavioral ratings, somatic symptoms, blood pressure and plasma levels of 3-methoxy-4-hydroxyphenethyleneglycol (MHPG) and cortisol were determined in 17 healthy subjects and 21 patients meeting DSM-III criteria for agoraphobia with panic attacks or panic disorder.	MHPG	panic attacks	2983630	-1
-The effects of oral administration of caffeine (10 mg/kg) on behavioral ratings, somatic symptoms, blood pressure and plasma levels of 3-methoxy-4-hydroxyphenethyleneglycol (MHPG) and cortisol were determined in 17 healthy subjects and 21 patients meeting DSM-III criteria for agoraphobia with panic attacks or panic disorder.	MHPG	panic disorder	2983630	-1
-The effects of oral administration of caffeine (10 mg/kg) on behavioral ratings, somatic symptoms, blood pressure and plasma levels of 3-methoxy-4-hydroxyphenethyleneglycol (MHPG) and cortisol were determined in 17 healthy subjects and 21 patients meeting DSM-III criteria for agoraphobia with panic attacks or panic disorder.	cortisol	agoraphobia	2983630	-1
-The effects of oral administration of caffeine (10 mg/kg) on behavioral ratings, somatic symptoms, blood pressure and plasma levels of 3-methoxy-4-hydroxyphenethyleneglycol (MHPG) and cortisol were determined in 17 healthy subjects and 21 patients meeting DSM-III criteria for agoraphobia with panic attacks or panic disorder.	cortisol	panic attacks	2983630	-1
-The effects of oral administration of caffeine (10 mg/kg) on behavioral ratings, somatic symptoms, blood pressure and plasma levels of 3-methoxy-4-hydroxyphenethyleneglycol (MHPG) and cortisol were determined in 17 healthy subjects and 21 patients meeting DSM-III criteria for agoraphobia with panic attacks or panic disorder.	cortisol	panic disorder	2983630	-1
-The effects of oral administration of caffeine (10 mg/kg) on behavioral ratings, somatic symptoms, blood pressure and plasma levels of 3-methoxy-4-hydroxyphenethyleneglycol (MHPG) and cortisol were determined in 17 healthy subjects and 21 patients meeting DSM-III criteria for agoraphobia with panic attacks or panic disorder.	caffeine	agoraphobia	2983630	-1
-The effects of oral administration of caffeine (10 mg/kg) on behavioral ratings, somatic symptoms, blood pressure and plasma levels of 3-methoxy-4-hydroxyphenethyleneglycol (MHPG) and cortisol were determined in 17 healthy subjects and 21 patients meeting DSM-III criteria for agoraphobia with panic attacks or panic disorder.	caffeine	panic attacks	2983630	-1
-The effects of oral administration of caffeine (10 mg/kg) on behavioral ratings, somatic symptoms, blood pressure and plasma levels of 3-methoxy-4-hydroxyphenethyleneglycol (MHPG) and cortisol were determined in 17 healthy subjects and 21 patients meeting DSM-III criteria for agoraphobia with panic attacks or panic disorder.	caffeine	panic disorder	2983630	-1
-Univariate analysis showed that the risk factors associated with seizures after pediatric LT included gender, pediatric end-stage liver disease score before surgery, Child-Pugh score before surgery, serum total bilirubin after surgery, and trough TAC level.	bilirubin	seizures	24283660	-1
-Univariate analysis showed that the risk factors associated with seizures after pediatric LT included gender, pediatric end-stage liver disease score before surgery, Child-Pugh score before surgery, serum total bilirubin after surgery, and trough TAC level.	bilirubin	end-stage liver disease	24283660	-1
-Univariate analysis showed that the risk factors associated with seizures after pediatric LT included gender, pediatric end-stage liver disease score before surgery, Child-Pugh score before surgery, serum total bilirubin after surgery, and trough TAC level.	TAC	seizures	24283660	1
-Univariate analysis showed that the risk factors associated with seizures after pediatric LT included gender, pediatric end-stage liver disease score before surgery, Child-Pugh score before surgery, serum total bilirubin after surgery, and trough TAC level.	TAC	end-stage liver disease	24283660	-1
-We report syncope and bradycardia in an 11-year-old girl following administration of intranasal dexmedetomidine for sedation for a voiding cystourethrogram.	dexmedetomidine	syncope	24571687	-1
-We report syncope and bradycardia in an 11-year-old girl following administration of intranasal dexmedetomidine for sedation for a voiding cystourethrogram.	dexmedetomidine	bradycardia	24571687	1
-Their combined cardiac toxicity may be due to independent effects of each drug; however, they may also be due to cocaethylene (CE), a cocaine metabolite formed only in the presence of ethanol.	cocaethylene	cardiac toxicity	11229942	-1
-Their combined cardiac toxicity may be due to independent effects of each drug; however, they may also be due to cocaethylene (CE), a cocaine metabolite formed only in the presence of ethanol.	CE	cardiac toxicity	11229942	-1
-Their combined cardiac toxicity may be due to independent effects of each drug; however, they may also be due to cocaethylene (CE), a cocaine metabolite formed only in the presence of ethanol.	cocaine	cardiac toxicity	11229942	-1
-Their combined cardiac toxicity may be due to independent effects of each drug; however, they may also be due to cocaethylene (CE), a cocaine metabolite formed only in the presence of ethanol.	ethanol	cardiac toxicity	11229942	-1
-1,3-Butadiene, CML and the t(9:22) translocation: A reality check.	1,3-Butadiene	CML	26002693	-1
-The purpose of this study was to delineate the role of CE in the combined cardiotoxicity of cocaine and ethanol in a model simulating their abuse.	CE	cardiotoxicity	11229942	-1
-The purpose of this study was to delineate the role of CE in the combined cardiotoxicity of cocaine and ethanol in a model simulating their abuse.	cocaine	cardiotoxicity	11229942	-1
-The purpose of this study was to delineate the role of CE in the combined cardiotoxicity of cocaine and ethanol in a model simulating their abuse.	ethanol	cardiotoxicity	11229942	-1
-A 30-year-old cocaine-dependent man who was a subject in a study evaluating the anticraving efficacy of the stimulant medication diethylpropion (DEP) became manic during his second week on the study drug.	diethylpropion	manic	9197951	1
-A 30-year-old cocaine-dependent man who was a subject in a study evaluating the anticraving efficacy of the stimulant medication diethylpropion (DEP) became manic during his second week on the study drug.	DEP	manic	9197951	1
-A 30-year-old cocaine-dependent man who was a subject in a study evaluating the anticraving efficacy of the stimulant medication diethylpropion (DEP) became manic during his second week on the study drug.	cocaine	manic	9197951	-1
-METHODS: We studied 9 patients with hypersensitivity to P and N with or without associated reactions to classic NSAIDs.	N	hypersensitivity	15859361	-1
-We undertook an open-label study using thalidomide 100 mg once daily for up to 6 months in 20 men with androgen-independent prostate cancer.	thalidomide	prostate cancer	12644816	-1
-Neurologic toxicities have been described with IT-methotrexate, IT-cytosine arabinoside and IT-TSPA.	methotrexate	Neurologic toxicities	2131034	-1
-Neurologic toxicities have been described with IT-methotrexate, IT-cytosine arabinoside and IT-TSPA.	cytosine arabinoside	Neurologic toxicities	2131034	-1
-PURPOSE: Despite its well-known cardiotoxicity, the anthracyclin doxorubicin (DOX) continues to be an effective and widely used chemotherapeutic agent.	anthracyclin doxorubicin	cardiotoxicity	16565833	-1
-PURPOSE: Despite its well-known cardiotoxicity, the anthracyclin doxorubicin (DOX) continues to be an effective and widely used chemotherapeutic agent.	DOX	cardiotoxicity	16565833	-1
-The intracerebroventricular (ICV) administration of ouabain (a Na(+)/K(+)-ATPase inhibitor) in rats has been suggested to mimic some symptoms of human bipolar mania.	ouabain	bipolar mania	19447152	1
-The intracerebroventricular (ICV) administration of ouabain (a Na(+)/K(+)-ATPase inhibitor) in rats has been suggested to mimic some symptoms of human bipolar mania.	Na(+)/K(+)-ATPase	bipolar mania	19447152	-1
-trazodone enhanced dexamphetamine stereotypy, and antagonized haloperidol catalepsy, ergometrine-induced WDS behavior and fluoxetine-induced penile erections.	trazodone	catalepsy	15614572	-1
-trazodone enhanced dexamphetamine stereotypy, and antagonized haloperidol catalepsy, ergometrine-induced WDS behavior and fluoxetine-induced penile erections.	dexamphetamine	catalepsy	15614572	-1
-trazodone enhanced dexamphetamine stereotypy, and antagonized haloperidol catalepsy, ergometrine-induced WDS behavior and fluoxetine-induced penile erections.	fluoxetine	catalepsy	15614572	-1
-trazodone enhanced dexamphetamine stereotypy, and antagonized haloperidol catalepsy, ergometrine-induced WDS behavior and fluoxetine-induced penile erections.	haloperidol	catalepsy	15614572	1
-trazodone enhanced dexamphetamine stereotypy, and antagonized haloperidol catalepsy, ergometrine-induced WDS behavior and fluoxetine-induced penile erections.	ergometrine	catalepsy	15614572	-1
-Alendronate, a biphosphonate, is effective for both the treatment and prevention of osteoporosis in postmenopausal women.	Alendronate	osteoporosis	20927253	-1
-Alendronate, a biphosphonate, is effective for both the treatment and prevention of osteoporosis in postmenopausal women.	biphosphonate	osteoporosis	20927253	-1
-Treatment with clentiazem prevented epinephrine-induced death (P < .05), and attenuated the ventricular ischemic lesions and fibrosis, in a dose-dependent manner.	epinephrine	ventricular ischemic lesions	8392553	-1
-Treatment with clentiazem prevented epinephrine-induced death (P < .05), and attenuated the ventricular ischemic lesions and fibrosis, in a dose-dependent manner.	epinephrine	death	8392553	-1
-Treatment with clentiazem prevented epinephrine-induced death (P < .05), and attenuated the ventricular ischemic lesions and fibrosis, in a dose-dependent manner.	epinephrine	fibrosis	8392553	-1
-Treatment with clentiazem prevented epinephrine-induced death (P < .05), and attenuated the ventricular ischemic lesions and fibrosis, in a dose-dependent manner.	clentiazem	ventricular ischemic lesions	8392553	-1
-Treatment with clentiazem prevented epinephrine-induced death (P < .05), and attenuated the ventricular ischemic lesions and fibrosis, in a dose-dependent manner.	clentiazem	death	8392553	-1
-Treatment with clentiazem prevented epinephrine-induced death (P < .05), and attenuated the ventricular ischemic lesions and fibrosis, in a dose-dependent manner.	clentiazem	fibrosis	8392553	-1
-This report describes a case of encephalopathy developed in the course of amitriptyline therapy, during a remission of unipolar depression.	amitriptyline	unipolar depression	8748050	-1
-A large population-based follow-up study of trimethoprim-sulfamethoxazole, trimethoprim, and cephalexin for uncommon serious drug toxicity.	trimethoprim	drug toxicity	7479194	-1
-A large population-based follow-up study of trimethoprim-sulfamethoxazole, trimethoprim, and cephalexin for uncommon serious drug toxicity.	cephalexin	drug toxicity	7479194	-1
-A large population-based follow-up study of trimethoprim-sulfamethoxazole, trimethoprim, and cephalexin for uncommon serious drug toxicity.	trimethoprim-sulfamethoxazole	drug toxicity	7479194	-1
-IMPLICATIONS: This case documents a patient who developed dizziness with downbeating nystagmus while receiving a relatively large dose of IV patient-controlled analgesia morphine.	morphine	dizziness	10960401	1
-Similarly, ganglionic blockade with hexamethonium caused a significantly greater fall in LNNA hypertensive rats (76 +/-	hexamethonium	hypertensive	16810074	-1
-OBJECTIVE: Quetiapine is a dibenzothiazepine derivative, similar to clozapine, which has the highest risk of causing blood dyscrasias, especially neutropenia.	clozapine	neutropenia	25084821	-1
-OBJECTIVE: Quetiapine is a dibenzothiazepine derivative, similar to clozapine, which has the highest risk of causing blood dyscrasias, especially neutropenia.	clozapine	blood dyscrasias	25084821	-1
-OBJECTIVE: Quetiapine is a dibenzothiazepine derivative, similar to clozapine, which has the highest risk of causing blood dyscrasias, especially neutropenia.	dibenzothiazepine	neutropenia	25084821	-1
-OBJECTIVE: Quetiapine is a dibenzothiazepine derivative, similar to clozapine, which has the highest risk of causing blood dyscrasias, especially neutropenia.	dibenzothiazepine	blood dyscrasias	25084821	-1
-OBJECTIVE: Quetiapine is a dibenzothiazepine derivative, similar to clozapine, which has the highest risk of causing blood dyscrasias, especially neutropenia.	Quetiapine	neutropenia	25084821	1
-OBJECTIVE: Quetiapine is a dibenzothiazepine derivative, similar to clozapine, which has the highest risk of causing blood dyscrasias, especially neutropenia.	Quetiapine	blood dyscrasias	25084821	-1
-He was put on aspirin following surgery and took ibuprofen for fever for nearly a week prior to presentation.	ibuprofen	fever	17879100	-1
-He was put on aspirin following surgery and took ibuprofen for fever for nearly a week prior to presentation.	aspirin	fever	17879100	-1
-This case report suggests that desvenlafaxine might cause clinically significant hyponatremia.	desvenlafaxine	hyponatremia	24234943	1
-Peak serum cocaethylene concentrations were associated with prolonged myocardial depression.	cocaethylene	myocardial depression	11229942	-1
-The authors report here a depressed patient comorbid with postprandial dyspepsia who developed RLS after mirtazapine had been added to his domperidone therapy.	domperidone	depressed	16309808	-1
-The authors report here a depressed patient comorbid with postprandial dyspepsia who developed RLS after mirtazapine had been added to his domperidone therapy.	domperidone	dyspepsia	16309808	-1
-The authors report here a depressed patient comorbid with postprandial dyspepsia who developed RLS after mirtazapine had been added to his domperidone therapy.	domperidone	RLS	16309808	-1
-The authors report here a depressed patient comorbid with postprandial dyspepsia who developed RLS after mirtazapine had been added to his domperidone therapy.	mirtazapine	depressed	16309808	-1
-The authors report here a depressed patient comorbid with postprandial dyspepsia who developed RLS after mirtazapine had been added to his domperidone therapy.	mirtazapine	dyspepsia	16309808	-1
-High-dose MP may be contraindicated in patients with known heart disease.	MP	heart disease	3798047	-1
-Bortezomib (bort)-dexamethasone (dex) is an effective therapy for relapsed/refractory (R/R) multiple myeloma (MM).	Bortezomib	multiple myeloma	23864035	-1
-Bortezomib (bort)-dexamethasone (dex) is an effective therapy for relapsed/refractory (R/R) multiple myeloma (MM).	Bortezomib	MM	23864035	-1
-Bortezomib (bort)-dexamethasone (dex) is an effective therapy for relapsed/refractory (R/R) multiple myeloma (MM).	bort)-dexamethasone	multiple myeloma	23864035	-1
-Bortezomib (bort)-dexamethasone (dex) is an effective therapy for relapsed/refractory (R/R) multiple myeloma (MM).	bort)-dexamethasone	MM	23864035	-1
-Bortezomib (bort)-dexamethasone (dex) is an effective therapy for relapsed/refractory (R/R) multiple myeloma (MM).	dex	multiple myeloma	23864035	-1
-Bortezomib (bort)-dexamethasone (dex) is an effective therapy for relapsed/refractory (R/R) multiple myeloma (MM).	dex	MM	23864035	-1
-Flurothyl ether produced hypothermia which was correlated with the duration of flurothyl exposure; however, the relationship of hypothermia to seizure induction was unclear.	Flurothyl	hypothermia	3685052	1
-Flurothyl ether produced hypothermia which was correlated with the duration of flurothyl exposure; however, the relationship of hypothermia to seizure induction was unclear.	Flurothyl	seizure	3685052	-1
-Flurothyl ether produced hypothermia which was correlated with the duration of flurothyl exposure; however, the relationship of hypothermia to seizure induction was unclear.	flurothyl	hypothermia	3685052	1
-Flurothyl ether produced hypothermia which was correlated with the duration of flurothyl exposure; however, the relationship of hypothermia to seizure induction was unclear.	flurothyl	seizure	3685052	-1
-This retrospective study investigated the combination of bort (1.3 mg/m(2) on days 1, 4, 8, and 11 every 3 weeks) and dex (20 mg on the day of and the day after bort) as salvage treatment in 85 patients with R/R MM after prior autologous stem cell transplantation or conventional chemotherapy.	bort	MM	23864035	-1
-This retrospective study investigated the combination of bort (1.3 mg/m(2) on days 1, 4, 8, and 11 every 3 weeks) and dex (20 mg on the day of and the day after bort) as salvage treatment in 85 patients with R/R MM after prior autologous stem cell transplantation or conventional chemotherapy.	bort	MM	23864035	-1
-This retrospective study investigated the combination of bort (1.3 mg/m(2) on days 1, 4, 8, and 11 every 3 weeks) and dex (20 mg on the day of and the day after bort) as salvage treatment in 85 patients with R/R MM after prior autologous stem cell transplantation or conventional chemotherapy.	dex	MM	23864035	-1
-< .01), and death, 100% (P < or = .01), compared with group 4. Group 6 received cocaine and diazepam followed by 10 mg/kg flumazenil.	diazepam	death	8135424	-1
-< .01), and death, 100% (P < or = .01), compared with group 4. Group 6 received cocaine and diazepam followed by 10 mg/kg flumazenil.	cocaine	death	8135424	-1
-< .01), and death, 100% (P < or = .01), compared with group 4. Group 6 received cocaine and diazepam followed by 10 mg/kg flumazenil.	flumazenil	death	8135424	-1
-These data suggest that while NO deficiency increases oxidative stress and sympathetic activity in both arterial and venous vessels, the impact on veins does not make a major contribution to this form of hypertension.	NO	hypertension	16810074	1
-BACKGROUND: Most patients presenting to emergency departments (EDs) with cocaine-associated chest pain are admitted for at least 12 hours and receive a "rule out acute coronary syndrome" protocol, often with noninvasive testing prior to discharge.	cocaine	acute coronary syndrome	19655282	-1
-BACKGROUND: Most patients presenting to emergency departments (EDs) with cocaine-associated chest pain are admitted for at least 12 hours and receive a "rule out acute coronary syndrome" protocol, often with noninvasive testing prior to discharge.	cocaine	chest pain	19655282	1
-Quinine, like quinidine, is a chincona alkaloid that has anti-arrhythmic property, although it also pro-arrhythmic that can cause various arrhythmias, including severe arrhythmia such as multiple PVC.	Quinine	arrhythmias	17297207	-1
-Quinine, like quinidine, is a chincona alkaloid that has anti-arrhythmic property, although it also pro-arrhythmic that can cause various arrhythmias, including severe arrhythmia such as multiple PVC.	Quinine	arrhythmia	17297207	-1
-Quinine, like quinidine, is a chincona alkaloid that has anti-arrhythmic property, although it also pro-arrhythmic that can cause various arrhythmias, including severe arrhythmia such as multiple PVC.	Quinine	PVC	17297207	1
-Quinine, like quinidine, is a chincona alkaloid that has anti-arrhythmic property, although it also pro-arrhythmic that can cause various arrhythmias, including severe arrhythmia such as multiple PVC.	quinidine	arrhythmias	17297207	-1
-Quinine, like quinidine, is a chincona alkaloid that has anti-arrhythmic property, although it also pro-arrhythmic that can cause various arrhythmias, including severe arrhythmia such as multiple PVC.	quinidine	arrhythmia	17297207	-1
-Quinine, like quinidine, is a chincona alkaloid that has anti-arrhythmic property, although it also pro-arrhythmic that can cause various arrhythmias, including severe arrhythmia such as multiple PVC.	quinidine	PVC	17297207	-1
-Our patient started to have symptoms of RLS only after he had been treated with mirtazapine, and his RLS symptoms resolved completely upon discontinuation of his mirtazapine.	mirtazapine	RLS	16309808	1
-Our patient started to have symptoms of RLS only after he had been treated with mirtazapine, and his RLS symptoms resolved completely upon discontinuation of his mirtazapine.	mirtazapine	RLS	16309808	1
-Baseline electrocardiogram abnormalities and market elevations not associated with myocardial necrosis make accurate diagnosis of myocardial infarction (MI) difficult in patients with cocaine-associated chest pain.	cocaine	myocardial necrosis	12359538	-1
-Baseline electrocardiogram abnormalities and market elevations not associated with myocardial necrosis make accurate diagnosis of myocardial infarction (MI) difficult in patients with cocaine-associated chest pain.	cocaine	myocardial infarction	12359538	1
-Baseline electrocardiogram abnormalities and market elevations not associated with myocardial necrosis make accurate diagnosis of myocardial infarction (MI) difficult in patients with cocaine-associated chest pain.	cocaine	MI	12359538	1
-Baseline electrocardiogram abnormalities and market elevations not associated with myocardial necrosis make accurate diagnosis of myocardial infarction (MI) difficult in patients with cocaine-associated chest pain.	cocaine	chest pain	12359538	-1
-Incidence of heparin-induced thrombocytopenia type II and postoperative recovery of platelet count in liver graft recipients: a retrospective cohort analysis.	heparin	thrombocytopenia	24100055	1
-Patients who are candidates for long-term cyclophosphamide treatment should be routinely evaluated for obstructive uropathy.	cyclophosphamide	obstructive uropathy	7248895	-1
-Conversion to SRL prevented CsA-induced renal damage evolution (absent/mild grade lesions), while NGAL (serum versus urine) seems to be a feasible biomarker of CsA replacement to SRL.	SRL	renal damage	24971338	-1
-Conversion to SRL prevented CsA-induced renal damage evolution (absent/mild grade lesions), while NGAL (serum versus urine) seems to be a feasible biomarker of CsA replacement to SRL.	SRL	renal damage	24971338	-1
-Conversion to SRL prevented CsA-induced renal damage evolution (absent/mild grade lesions), while NGAL (serum versus urine) seems to be a feasible biomarker of CsA replacement to SRL.	CsA	renal damage	24971338	1
-Conversion to SRL prevented CsA-induced renal damage evolution (absent/mild grade lesions), while NGAL (serum versus urine) seems to be a feasible biomarker of CsA replacement to SRL.	CsA	renal damage	24971338	1
-Radiolabelling, following the in vivo injection of 3H-17 beta estradiol, was increased only over the nuclei of tumor cells; stereologic analysis revealed a 4.5- to 6.7-times higher concentration of reduced silver grains over nuclei than cytoplasm of these cells.	silver	tumor	2650911	-1
-Radiolabelling, following the in vivo injection of 3H-17 beta estradiol, was increased only over the nuclei of tumor cells; stereologic analysis revealed a 4.5- to 6.7-times higher concentration of reduced silver grains over nuclei than cytoplasm of these cells.	3H-17 beta estradiol	tumor	2650911	-1
-BACKGROUND: Pre-treatment with lipid emulsions has been shown to increase lethal doses of bupivacaine, and the lipid content of propofol may alleviate bupivacaine-induced cardiotoxicity.	propofol	cardiotoxicity	24438483	-1
-Optochiasmatic and peripheral neuropathy due to ethambutol overtreatment.	ethambutol	peripheral neuropathy	24897009	-1
-Thus it appears that the difference between seizure sensitive and insensitive animals may be due to a difference in hippocampal nicotinic receptor concentration as measured with alpha-bungarotoxin binding.	alpha-bungarotoxin	seizure	4010471	-1
-Patients who had ARI after high-dose melphalan underwent dialysis more often (P = 0.007), and had a worse 1-year survival (P = 0.03). CONCLUSION	melphalan	ARI	15696449	1
-Lateral antebrachial cutaneous neuropathy after steroid injection at lateral epicondyle.	steroid	cutaneous neuropathy	25096313	-1
-These findings result in a model that allows the testing of protectors against doxorubicin-induced cardiotoxicity as demonstrated by the protection provided by ICRF-187.	ICRF-187	cardiotoxicity	8603459	-1
-Such a temporal relationship between the use of mirtazapine and the symptoms of RLS in our patient did not support a potentiating effect of domperione on mirtazapine-associated RLS.	mirtazapine	RLS	16309808	1
-BACKGROUND AND OBJECTIVES: This report aimed to present a case of lateral antebrachial cutaneous neuropathy (LACNP) that occurred after a steroid injection in the lateral epicondyle to treat lateral epicondylitis in a 40-year-old woman	steroid	lateral epicondylitis	25096313	-1
-BACKGROUND AND OBJECTIVES: This report aimed to present a case of lateral antebrachial cutaneous neuropathy (LACNP) that occurred after a steroid injection in the lateral epicondyle to treat lateral epicondylitis in a 40-year-old woman	steroid	cutaneous neuropathy	25096313	-1
-We report the occurrence of severe hypertension (blood pressure 190/160) in a 4-year-old girl with neuroblastoma who was given Imipramine to control a behavior disorder.	Imipramine	behavior disorder	3439580	-1
-We report the occurrence of severe hypertension (blood pressure 190/160) in a 4-year-old girl with neuroblastoma who was given Imipramine to control a behavior disorder.	Imipramine	hypertension	3439580	1
-We report the occurrence of severe hypertension (blood pressure 190/160) in a 4-year-old girl with neuroblastoma who was given Imipramine to control a behavior disorder.	Imipramine	neuroblastoma	3439580	-1
-Amiodarone is an anti-arrhythmic drug for life-threatening tachycardia, but various adverse effects have been reported.	Amiodarone	tachycardia	18801087	-1
-Continuous infusion tobramycin combined with carbenicillin for infections in cancer patients.	carbenicillin	infections	256433	-1
-Continuous infusion tobramycin combined with carbenicillin for infections in cancer patients.	carbenicillin	cancer	256433	-1
-Continuous infusion tobramycin combined with carbenicillin for infections in cancer patients.	tobramycin	infections	256433	-1
-Continuous infusion tobramycin combined with carbenicillin for infections in cancer patients.	tobramycin	cancer	256433	-1
-All-trans retinoic acid (ATRA), a component of standard therapy for acute promyelocytic leukemia (APL), is associated with potentially serious but treatable adverse effects involving numerous organ systems, including rare skeletal muscle involvement.	All-trans retinoic acid	acute promyelocytic leukemia	24658375	-1
-All-trans retinoic acid (ATRA), a component of standard therapy for acute promyelocytic leukemia (APL), is associated with potentially serious but treatable adverse effects involving numerous organ systems, including rare skeletal muscle involvement.	All-trans retinoic acid	APL	24658375	-1
-All-trans retinoic acid (ATRA), a component of standard therapy for acute promyelocytic leukemia (APL), is associated with potentially serious but treatable adverse effects involving numerous organ systems, including rare skeletal muscle involvement.	ATRA	acute promyelocytic leukemia	24658375	-1
-All-trans retinoic acid (ATRA), a component of standard therapy for acute promyelocytic leukemia (APL), is associated with potentially serious but treatable adverse effects involving numerous organ systems, including rare skeletal muscle involvement.	ATRA	APL	24658375	-1
-Temocapril, a long-acting non-SH group angiotensin converting enzyme inhibitor, modulates glomerular injury in chronic puromycin aminonucleoside nephrosis.	angiotensin	glomerular injury	11936424	-1
-Temocapril, a long-acting non-SH group angiotensin converting enzyme inhibitor, modulates glomerular injury in chronic puromycin aminonucleoside nephrosis.	angiotensin	nephrosis	11936424	-1
-Temocapril, a long-acting non-SH group angiotensin converting enzyme inhibitor, modulates glomerular injury in chronic puromycin aminonucleoside nephrosis.	puromycin aminonucleoside	glomerular injury	11936424	-1
-Temocapril, a long-acting non-SH group angiotensin converting enzyme inhibitor, modulates glomerular injury in chronic puromycin aminonucleoside nephrosis.	Temocapril	glomerular injury	11936424	-1
-Temocapril, a long-acting non-SH group angiotensin converting enzyme inhibitor, modulates glomerular injury in chronic puromycin aminonucleoside nephrosis.	Temocapril	nephrosis	11936424	-1
-Patients with the diagnosis of methamphetamine based on DSM-IV were interviewed using the Mini International Neuropsychiatric Interview (M.I.N.I.) for methamphetamine-induced psychosis and other Axis I psychiatric disorders.	methamphetamine	psychiatric disorders	23433219	-1
-Patients with the diagnosis of methamphetamine based on DSM-IV were interviewed using the Mini International Neuropsychiatric Interview (M.I.N.I.) for methamphetamine-induced psychosis and other Axis I psychiatric disorders.	methamphetamine	psychiatric disorders	23433219	-1
-CONCLUSION: We conclude that patients with osteoporosis can report pain, and bisphosphonate-related pain should also be considered before ascribing this complaint to osteoporosis.	bisphosphonate	pain	20927253	-1
-CONCLUSION: We conclude that patients with osteoporosis can report pain, and bisphosphonate-related pain should also be considered before ascribing this complaint to osteoporosis.	bisphosphonate	pain	20927253	-1
-CONCLUSION: We conclude that patients with osteoporosis can report pain, and bisphosphonate-related pain should also be considered before ascribing this complaint to osteoporosis.	bisphosphonate	osteoporosis	20927253	-1
-CONCLUSION: We conclude that patients with osteoporosis can report pain, and bisphosphonate-related pain should also be considered before ascribing this complaint to osteoporosis.	bisphosphonate	osteoporosis	20927253	-1
-The purpose of the present study was to determine whether chronic administration of temocapril, a long-acting non-SH group angiotensin converting enzyme (ACE) inhibitor, reduced proteinuria, inhibited glomerular hypertrophy and prevented glomerulosclerosis in chronic puromycin aminonucleoside (PAN) - induced nephrotic rats.	angiotensin	nephrotic	11936424	-1
-The purpose of the present study was to determine whether chronic administration of temocapril, a long-acting non-SH group angiotensin converting enzyme (ACE) inhibitor, reduced proteinuria, inhibited glomerular hypertrophy and prevented glomerulosclerosis in chronic puromycin aminonucleoside (PAN) - induced nephrotic rats.	angiotensin	glomerulosclerosis	11936424	-1
-The purpose of the present study was to determine whether chronic administration of temocapril, a long-acting non-SH group angiotensin converting enzyme (ACE) inhibitor, reduced proteinuria, inhibited glomerular hypertrophy and prevented glomerulosclerosis in chronic puromycin aminonucleoside (PAN) - induced nephrotic rats.	angiotensin	glomerular hypertrophy	11936424	-1
-The purpose of the present study was to determine whether chronic administration of temocapril, a long-acting non-SH group angiotensin converting enzyme (ACE) inhibitor, reduced proteinuria, inhibited glomerular hypertrophy and prevented glomerulosclerosis in chronic puromycin aminonucleoside (PAN) - induced nephrotic rats.	angiotensin	proteinuria	11936424	-1
-The purpose of the present study was to determine whether chronic administration of temocapril, a long-acting non-SH group angiotensin converting enzyme (ACE) inhibitor, reduced proteinuria, inhibited glomerular hypertrophy and prevented glomerulosclerosis in chronic puromycin aminonucleoside (PAN) - induced nephrotic rats.	puromycin aminonucleoside	nephrotic	11936424	-1
-The purpose of the present study was to determine whether chronic administration of temocapril, a long-acting non-SH group angiotensin converting enzyme (ACE) inhibitor, reduced proteinuria, inhibited glomerular hypertrophy and prevented glomerulosclerosis in chronic puromycin aminonucleoside (PAN) - induced nephrotic rats.	puromycin aminonucleoside	glomerulosclerosis	11936424	-1
-The purpose of the present study was to determine whether chronic administration of temocapril, a long-acting non-SH group angiotensin converting enzyme (ACE) inhibitor, reduced proteinuria, inhibited glomerular hypertrophy and prevented glomerulosclerosis in chronic puromycin aminonucleoside (PAN) - induced nephrotic rats.	puromycin aminonucleoside	glomerular hypertrophy	11936424	-1
-The purpose of the present study was to determine whether chronic administration of temocapril, a long-acting non-SH group angiotensin converting enzyme (ACE) inhibitor, reduced proteinuria, inhibited glomerular hypertrophy and prevented glomerulosclerosis in chronic puromycin aminonucleoside (PAN) - induced nephrotic rats.	puromycin aminonucleoside	proteinuria	11936424	1
-The purpose of the present study was to determine whether chronic administration of temocapril, a long-acting non-SH group angiotensin converting enzyme (ACE) inhibitor, reduced proteinuria, inhibited glomerular hypertrophy and prevented glomerulosclerosis in chronic puromycin aminonucleoside (PAN) - induced nephrotic rats.	PAN	nephrotic	11936424	-1
-The purpose of the present study was to determine whether chronic administration of temocapril, a long-acting non-SH group angiotensin converting enzyme (ACE) inhibitor, reduced proteinuria, inhibited glomerular hypertrophy and prevented glomerulosclerosis in chronic puromycin aminonucleoside (PAN) - induced nephrotic rats.	PAN	glomerulosclerosis	11936424	-1
-The purpose of the present study was to determine whether chronic administration of temocapril, a long-acting non-SH group angiotensin converting enzyme (ACE) inhibitor, reduced proteinuria, inhibited glomerular hypertrophy and prevented glomerulosclerosis in chronic puromycin aminonucleoside (PAN) - induced nephrotic rats.	PAN	glomerular hypertrophy	11936424	-1
-The purpose of the present study was to determine whether chronic administration of temocapril, a long-acting non-SH group angiotensin converting enzyme (ACE) inhibitor, reduced proteinuria, inhibited glomerular hypertrophy and prevented glomerulosclerosis in chronic puromycin aminonucleoside (PAN) - induced nephrotic rats.	PAN	proteinuria	11936424	1
-The purpose of the present study was to determine whether chronic administration of temocapril, a long-acting non-SH group angiotensin converting enzyme (ACE) inhibitor, reduced proteinuria, inhibited glomerular hypertrophy and prevented glomerulosclerosis in chronic puromycin aminonucleoside (PAN) - induced nephrotic rats.	temocapril	nephrotic	11936424	-1
-The purpose of the present study was to determine whether chronic administration of temocapril, a long-acting non-SH group angiotensin converting enzyme (ACE) inhibitor, reduced proteinuria, inhibited glomerular hypertrophy and prevented glomerulosclerosis in chronic puromycin aminonucleoside (PAN) - induced nephrotic rats.	temocapril	glomerulosclerosis	11936424	-1
-The purpose of the present study was to determine whether chronic administration of temocapril, a long-acting non-SH group angiotensin converting enzyme (ACE) inhibitor, reduced proteinuria, inhibited glomerular hypertrophy and prevented glomerulosclerosis in chronic puromycin aminonucleoside (PAN) - induced nephrotic rats.	temocapril	glomerular hypertrophy	11936424	-1
-The purpose of the present study was to determine whether chronic administration of temocapril, a long-acting non-SH group angiotensin converting enzyme (ACE) inhibitor, reduced proteinuria, inhibited glomerular hypertrophy and prevented glomerulosclerosis in chronic puromycin aminonucleoside (PAN) - induced nephrotic rats.	temocapril	proteinuria	11936424	-1
-Nephrosis was induced by injection of PAN (15mg/100g body weight) in male Sprague-Dawley (SD) rats.	PAN	Nephrosis	11936424	1
-Effect of vincristine sulfate on Pseudomonas infections in monkeys.	vincristine sulfate	infections	4631913	-1
-However, physicians should be aware of the possibility that mirtazapine can be associated with RLS in some individuals, especially those receiving concomitant dopamine D2 receptor antagonists.	dopamine	RLS	16309808	-1
-The hazard of developing CAD (95% CI) associated with initial treatment increased by 2.4-fold (1.3-4.3, P=0.004) with glibenclamide; 2-fold (0.9-4.6, P=0.099) with glipizide; 2.9-fold (1.6-5.1, P=0.000) with either, and was unchanged with metformin.	glibenclamide	CAD	18945509	1
-The hazard of developing CAD (95% CI) associated with initial treatment increased by 2.4-fold (1.3-4.3, P=0.004) with glibenclamide; 2-fold (0.9-4.6, P=0.099) with glipizide; 2.9-fold (1.6-5.1, P=0.000) with either, and was unchanged with metformin.	glipizide	CAD	18945509	-1
-The hazard of developing CAD (95% CI) associated with initial treatment increased by 2.4-fold (1.3-4.3, P=0.004) with glibenclamide; 2-fold (0.9-4.6, P=0.099) with glipizide; 2.9-fold (1.6-5.1, P=0.000) with either, and was unchanged with metformin.	metformin	CAD	18945509	-1
-We present a case where a patient developed features of encephalopathy following prolonged metronidazole intake.	metronidazole	encephalopathy	24816962	1
-Thirty-six rats bearing breast tumors induced chemically were divided into 4 groups: control, hydroxytyrosol (0.5mg/kg, 5days/week), doxorubicin (1mg/kg/week), and doxorubicin plus hydroxytyrosol.	doxorubicin	breast tumors	24727461	-1
-Thirty-six rats bearing breast tumors induced chemically were divided into 4 groups: control, hydroxytyrosol (0.5mg/kg, 5days/week), doxorubicin (1mg/kg/week), and doxorubicin plus hydroxytyrosol.	doxorubicin	breast tumors	24727461	-1
-Thirty-six rats bearing breast tumors induced chemically were divided into 4 groups: control, hydroxytyrosol (0.5mg/kg, 5days/week), doxorubicin (1mg/kg/week), and doxorubicin plus hydroxytyrosol.	hydroxytyrosol	breast tumors	24727461	-1
-Thirty-six rats bearing breast tumors induced chemically were divided into 4 groups: control, hydroxytyrosol (0.5mg/kg, 5days/week), doxorubicin (1mg/kg/week), and doxorubicin plus hydroxytyrosol.	hydroxytyrosol	breast tumors	24727461	-1
-Concerns about long-term methotrexate (MTX) neurotoxicity in the 1990s led to modifications in intrathecal (IT) therapy, leucovorin rescue, and frequency of systemic MTX administration in children with acute lymphoblastic leukemia.	methotrexate	acute lymphoblastic leukemia	24345882	-1
-Concerns about long-term methotrexate (MTX) neurotoxicity in the 1990s led to modifications in intrathecal (IT) therapy, leucovorin rescue, and frequency of systemic MTX administration in children with acute lymphoblastic leukemia.	methotrexate	neurotoxicity	24345882	-1
-Concerns about long-term methotrexate (MTX) neurotoxicity in the 1990s led to modifications in intrathecal (IT) therapy, leucovorin rescue, and frequency of systemic MTX administration in children with acute lymphoblastic leukemia.	MTX	acute lymphoblastic leukemia	24345882	-1
-Concerns about long-term methotrexate (MTX) neurotoxicity in the 1990s led to modifications in intrathecal (IT) therapy, leucovorin rescue, and frequency of systemic MTX administration in children with acute lymphoblastic leukemia.	MTX	neurotoxicity	24345882	-1
-Concerns about long-term methotrexate (MTX) neurotoxicity in the 1990s led to modifications in intrathecal (IT) therapy, leucovorin rescue, and frequency of systemic MTX administration in children with acute lymphoblastic leukemia.	MTX	acute lymphoblastic leukemia	24345882	-1
-Concerns about long-term methotrexate (MTX) neurotoxicity in the 1990s led to modifications in intrathecal (IT) therapy, leucovorin rescue, and frequency of systemic MTX administration in children with acute lymphoblastic leukemia.	MTX	neurotoxicity	24345882	-1
-Concerns about long-term methotrexate (MTX) neurotoxicity in the 1990s led to modifications in intrathecal (IT) therapy, leucovorin rescue, and frequency of systemic MTX administration in children with acute lymphoblastic leukemia.	leucovorin	acute lymphoblastic leukemia	24345882	-1
-Concerns about long-term methotrexate (MTX) neurotoxicity in the 1990s led to modifications in intrathecal (IT) therapy, leucovorin rescue, and frequency of systemic MTX administration in children with acute lymphoblastic leukemia.	leucovorin	neurotoxicity	24345882	-1
-We report a case of acute interstitial nephritis (AIN) due to nicergoline (Sermion).	nicergoline	AIN	12372954	-1
-Hypertension in neuroblastoma induced by imipramine.	imipramine	neuroblastoma	3439580	-1
-Ongoing tubular injury may be a prerequisite for renal injury by melphalan as evidenced by the active urinary sediment.	melphalan	Ongoing tubular injury	15696449	-1
-Ongoing tubular injury may be a prerequisite for renal injury by melphalan as evidenced by the active urinary sediment.	melphalan	renal injury	15696449	-1
-The results revealed that the lack of cannabinoid CB1 receptors increased the severity of motor impairment and DA lesion, and reduced L-DOPA-induced dyskinesias.	cannabinoid	dyskinesias	19419794	-1
-The results revealed that the lack of cannabinoid CB1 receptors increased the severity of motor impairment and DA lesion, and reduced L-DOPA-induced dyskinesias.	DA	dyskinesias	19419794	-1
-The results revealed that the lack of cannabinoid CB1 receptors increased the severity of motor impairment and DA lesion, and reduced L-DOPA-induced dyskinesias.	L-DOPA	dyskinesias	19419794	1
-In isolated hearts, Iso induced a significantly greater increase in left ventricular (LV) pressure and maximal contraction (+dP/dt(max)) in the TGR than in the Sprague-Dawley (SD) rats.	Iso	LV	16731636	-1
-Before admission, he had been taking nicergoline and bendazac lysine due to retinal vein occlusion at ophthalmologic department.	nicergoline	retinal vein occlusion	12372954	-1
-Before admission, he had been taking nicergoline and bendazac lysine due to retinal vein occlusion at ophthalmologic department.	bendazac lysine	retinal vein occlusion	12372954	-1
-We have previously demonstrated that endothelial-mesenchymal-transition (EndoMT) contributes to the early development of renal interstitial fibrosis independently of microalbuminuria in mice with streptozotocin (STZ)-induced diabetes.	streptozotocin	renal interstitial fibrosis independently of microalbuminuria	20682692	-1
-We have previously demonstrated that endothelial-mesenchymal-transition (EndoMT) contributes to the early development of renal interstitial fibrosis independently of microalbuminuria in mice with streptozotocin (STZ)-induced diabetes.	streptozotocin	diabetes	20682692	-1
-We have previously demonstrated that endothelial-mesenchymal-transition (EndoMT) contributes to the early development of renal interstitial fibrosis independently of microalbuminuria in mice with streptozotocin (STZ)-induced diabetes.	STZ)-induced	renal interstitial fibrosis independently of microalbuminuria	20682692	-1
-We have previously demonstrated that endothelial-mesenchymal-transition (EndoMT) contributes to the early development of renal interstitial fibrosis independently of microalbuminuria in mice with streptozotocin (STZ)-induced diabetes.	STZ)-induced	diabetes	20682692	-1
-These results suggest that activation of CB1 receptors offers neuroprotection against dopaminergic lesion and the development of L-DOPA-induced dyskinesias.	L-DOPA	dyskinesias	19419794	1
-Delayed toxicity of cyclophosphamide on the bladder of DBA/2 and C57BL/6 female mouse.	cyclophosphamide	toxicity	12059909	-1
-After 30 days of CY injection ulcerous and non-ulcerous forms of chronic cystitis appeared in 86% of DBA/2 mice but only in 4% of C57BL/6 mice.	CY	cystitis	12059909	1
-After 30 days of CY injection ulcerous and non-ulcerous forms of chronic cystitis appeared in 86% of DBA/2 mice but only in 4% of C57BL/6 mice.	CY	ulcerous	12059909	-1
-After 30 days of CY injection ulcerous and non-ulcerous forms of chronic cystitis appeared in 86% of DBA/2 mice but only in 4% of C57BL/6 mice.	CY	ulcerous	12059909	-1
-It is recommended that all cases of methamphetamine dependence should be screened for psychotic symptoms.	methamphetamine	psychotic symptoms	23433219	1
-Glomeruli with sclerosis contained significantly more CC than non-sclerotic glomeruli in the same kidneys.	CC	sclerosis	3990093	-1
-Comparison of effects of isotonic sodium chloride with diltiazem in prevention of contrast-induced nephropathy.	diltiazem	nephropathy	24341598	-1
-Comparison of effects of isotonic sodium chloride with diltiazem in prevention of contrast-induced nephropathy.	sodium chloride	nephropathy	24341598	-1
-Thirty-six nonobese subjects with schizophrenia or schizoaffective disorder, matched by body mass index and treated with either clozapine, olanzapine, or risperidone, were included in the analysis.	clozapine	schizoaffective disorder	15630069	-1
-Thirty-six nonobese subjects with schizophrenia or schizoaffective disorder, matched by body mass index and treated with either clozapine, olanzapine, or risperidone, were included in the analysis.	clozapine	schizophrenia	15630069	-1
-Thirty-six nonobese subjects with schizophrenia or schizoaffective disorder, matched by body mass index and treated with either clozapine, olanzapine, or risperidone, were included in the analysis.	risperidone	schizoaffective disorder	15630069	-1
-Thirty-six nonobese subjects with schizophrenia or schizoaffective disorder, matched by body mass index and treated with either clozapine, olanzapine, or risperidone, were included in the analysis.	risperidone	schizophrenia	15630069	-1
-Thirty-six nonobese subjects with schizophrenia or schizoaffective disorder, matched by body mass index and treated with either clozapine, olanzapine, or risperidone, were included in the analysis.	olanzapine	schizoaffective disorder	15630069	-1
-Thirty-six nonobese subjects with schizophrenia or schizoaffective disorder, matched by body mass index and treated with either clozapine, olanzapine, or risperidone, were included in the analysis.	olanzapine	schizophrenia	15630069	-1
-Acute encephalopathy and cerebral vasospasm after multiagent chemotherapy including PEG-asparaginase and intrathecal cytarabine for the treatment of acute lymphoblastic leukemia.	PEG	encephalopathy	17356399	-1
-Acute encephalopathy and cerebral vasospasm after multiagent chemotherapy including PEG-asparaginase and intrathecal cytarabine for the treatment of acute lymphoblastic leukemia.	PEG	acute lymphoblastic leukemia	17356399	-1
-Acute encephalopathy and cerebral vasospasm after multiagent chemotherapy including PEG-asparaginase and intrathecal cytarabine for the treatment of acute lymphoblastic leukemia.	PEG	cerebral vasospasm	17356399	-1
-Acute encephalopathy and cerebral vasospasm after multiagent chemotherapy including PEG-asparaginase and intrathecal cytarabine for the treatment of acute lymphoblastic leukemia.	cytarabine	encephalopathy	17356399	-1
-Acute encephalopathy and cerebral vasospasm after multiagent chemotherapy including PEG-asparaginase and intrathecal cytarabine for the treatment of acute lymphoblastic leukemia.	cytarabine	acute lymphoblastic leukemia	17356399	-1
-This study examined the frequency of atrioventricular (AV) dissociation and accelerated junctional rhythms in 59 patients receiving oral verapamil.	verapamil	atrioventricular (AV) dissociation	6695685	-1
-A case of phenytoin (DPH) encephalopathy with increasing seizures and EEG and mental changes is described.	phenytoin	encephalopathy	891494	1
-A case of phenytoin (DPH) encephalopathy with increasing seizures and EEG and mental changes is described.	phenytoin	seizures	891494	-1
-A case of phenytoin (DPH) encephalopathy with increasing seizures and EEG and mental changes is described.	DPH	seizures	891494	-1
-Pubertal exposure to Bisphenol A increases anxiety-like behavior and decreases acetylcholinesterase activity of hippocampus in adult male mice.	Bisphenol A	anxiety	23871786	1
-CONCLUSION: Those using methadone and heroin simultaneously may increase risk of rhabdomyolysis and ischemic stroke.	heroin	ischemic stroke	19392810	-1
-CONCLUSION: Those using methadone and heroin simultaneously may increase risk of rhabdomyolysis and ischemic stroke.	heroin	rhabdomyolysis	19392810	1
-CONCLUSION: Those using methadone and heroin simultaneously may increase risk of rhabdomyolysis and ischemic stroke.	methadone	ischemic stroke	19392810	-1
-CONCLUSION: Those using methadone and heroin simultaneously may increase risk of rhabdomyolysis and ischemic stroke.	methadone	rhabdomyolysis	19392810	1
-CONCLUSION: We observed that DHEA reduced locomotor activity and increased catalepsy at both doses, while it had no effect on climbing behavior.	DHEA	catalepsy	24739405	-1
-Administration of parenteral quinine must be done carefully and with good observation because of its pro-arrhythmic effect, especially in older patients who have heart diseases or patients with electrolyte disorder (hypokalemia) which frequently occurs due to vomiting and or diarrhea in malaria cases.	quinine	diarrhea	17297207	-1
-Administration of parenteral quinine must be done carefully and with good observation because of its pro-arrhythmic effect, especially in older patients who have heart diseases or patients with electrolyte disorder (hypokalemia) which frequently occurs due to vomiting and or diarrhea in malaria cases.	quinine	malaria	17297207	-1
-Administration of parenteral quinine must be done carefully and with good observation because of its pro-arrhythmic effect, especially in older patients who have heart diseases or patients with electrolyte disorder (hypokalemia) which frequently occurs due to vomiting and or diarrhea in malaria cases.	quinine	heart diseases	17297207	-1
-Administration of parenteral quinine must be done carefully and with good observation because of its pro-arrhythmic effect, especially in older patients who have heart diseases or patients with electrolyte disorder (hypokalemia) which frequently occurs due to vomiting and or diarrhea in malaria cases.	quinine	vomiting	17297207	-1
-Administration of parenteral quinine must be done carefully and with good observation because of its pro-arrhythmic effect, especially in older patients who have heart diseases or patients with electrolyte disorder (hypokalemia) which frequently occurs due to vomiting and or diarrhea in malaria cases.	quinine	hypokalemia	17297207	-1
-Lactoferrin (LF) is an iron-binding glycoprotein with antihypertensive properties.	iron	LF	24587916	-1
-Lactoferrin (LF) is an iron-binding glycoprotein with antihypertensive properties.	Lactoferrin	LF	24587916	-1
-Focal cerebral ischemia in rats: effect of phenylephrine-induced hypertension during reperfusion.	phenylephrine	cerebral ischemia	15815446	-1
-Here, the impact of p53 inhibition on acute vs. late-stage DOX cardiotoxicity was examined in a juvenile model.	DOX	cardiotoxicity	24812279	-1
-After sacrifice the hearts of doxorubicin-treated animals were enlarged and the atria were hypertrophic.	doxorubicin	hypertrophic	8603459	-1
-After 180 min of temporary middle cerebral artery occlusion in spontaneously hypertensive rats, the effect of phenylephrine-induced hypertension on ischemic brain injury and blood-brain barrier permeability was determined.	phenylephrine	ischemic brain injury	15815446	-1
-After 180 min of temporary middle cerebral artery occlusion in spontaneously hypertensive rats, the effect of phenylephrine-induced hypertension on ischemic brain injury and blood-brain barrier permeability was determined.	phenylephrine	hypertensive	15815446	1
-After 180 min of temporary middle cerebral artery occlusion in spontaneously hypertensive rats, the effect of phenylephrine-induced hypertension on ischemic brain injury and blood-brain barrier permeability was determined.	phenylephrine	middle cerebral artery occlusion	15815446	-1
-Part A, for eight rats in each group brain injury was evaluated by staining tissue using 2,3,5-triphenyltetrazolium chloride and edema was evaluated by microgravimetry.	2,3,5-triphenyltetrazolium chloride	brain injury	15815446	-1
-Part A, for eight rats in each group brain injury was evaluated by staining tissue using 2,3,5-triphenyltetrazolium chloride and edema was evaluated by microgravimetry.	2,3,5-triphenyltetrazolium chloride	edema	15815446	-1
-(P < .01) at 3 min after ISO infusion with stenosis.	ISO	stenosis	8819482	-1
-There was a significant difference among groups in glucose effectiveness (F(30) = 4.18; P = .02) (clozapine<olanzapine<risperidone) with significant differences between clozapine and risperidone (t(30) = -2.59; P = .02) and olanzapine and risperidone (t(30) = -2.34, P = .03).	clozapine	glucose effectiveness	15630069	-1
-There was a significant difference among groups in glucose effectiveness (F(30) = 4.18; P = .02) (clozapine<olanzapine<risperidone) with significant differences between clozapine and risperidone (t(30) = -2.59; P = .02) and olanzapine and risperidone (t(30) = -2.34, P = .03).	olanzapine	glucose effectiveness	15630069	-1
-There was a significant difference among groups in glucose effectiveness (F(30) = 4.18; P = .02) (clozapine<olanzapine<risperidone) with significant differences between clozapine and risperidone (t(30) = -2.59; P = .02) and olanzapine and risperidone (t(30) = -2.34, P = .03).	clozapine<olanzapine<risperidone	glucose effectiveness	15630069	-1
-There was a significant difference among groups in glucose effectiveness (F(30) = 4.18; P = .02) (clozapine<olanzapine<risperidone) with significant differences between clozapine and risperidone (t(30) = -2.59; P = .02) and olanzapine and risperidone (t(30) = -2.34, P = .03).	risperidone	glucose effectiveness	15630069	-1
-There was a significant difference among groups in glucose effectiveness (F(30) = 4.18; P = .02) (clozapine<olanzapine<risperidone) with significant differences between clozapine and risperidone (t(30) = -2.59; P = .02) and olanzapine and risperidone (t(30) = -2.34, P = .03).	risperidone	glucose effectiveness	15630069	-1
-Hyperkalemia induced by indomethacin and naproxen and reversed by fludrocortisone.	fludrocortisone	Hyperkalemia	3375885	-1
-Brain injury (percentage of the ischemic hemisphere) was less in the 15/HTN group (16 +/-	15/HTN	Brain injury	15815446	-1
-Brain injury (percentage of the ischemic hemisphere) was less in the 15/HTN group (16 +/-	15/HTN	ischemic	15815446	-1
-These data show that CD-832 improves myocardial ischemia during ISO infusion with stenosis and suggest that the negative chronotropic property of CD-832 plays a major role in the beneficial effects of CD-832.	ISO	stenosis	8819482	-1
-These data show that CD-832 improves myocardial ischemia during ISO infusion with stenosis and suggest that the negative chronotropic property of CD-832 plays a major role in the beneficial effects of CD-832.	ISO	myocardial ischemia	8819482	1
-CONCLUSIONS: Both nonobese clozapine- and olanzapine-treated groups displayed significant insulin resistance and impairment of glucose effectiveness compared with risperidone-treated subjects.	clozapine-	impairment of glucose effectiveness	15630069	-1
-CONCLUSIONS: Both nonobese clozapine- and olanzapine-treated groups displayed significant insulin resistance and impairment of glucose effectiveness compared with risperidone-treated subjects.	risperidone	impairment of glucose effectiveness	15630069	-1
-CONCLUSIONS: Both nonobese clozapine- and olanzapine-treated groups displayed significant insulin resistance and impairment of glucose effectiveness compared with risperidone-treated subjects.	olanzapine	impairment of glucose effectiveness	15630069	-1
-It is likely that preexisting renal disease predisposed this patient to type IV renal tubular acidosis with prostaglandin synthetase inhibitors.	prostaglandin	renal disease	3375885	-1
-It is likely that preexisting renal disease predisposed this patient to type IV renal tubular acidosis with prostaglandin synthetase inhibitors.	prostaglandin	type IV renal tubular acidosis	3375885	-1
-These results indicate that status epilepticus induced by pilocarpine is initiated by cholinergic overstimulation and propagated by glutamatergic transmission, the elevation of which may cause brain damage through an excitatory NMDA receptor-mediated mechanism.	pilocarpine	status epilepticus	9061777	1
-These results indicate that status epilepticus induced by pilocarpine is initiated by cholinergic overstimulation and propagated by glutamatergic transmission, the elevation of which may cause brain damage through an excitatory NMDA receptor-mediated mechanism.	pilocarpine	brain damage	9061777	-1
-Because he was unable to discontinue nonsteroidal anti-inflammatory drug therapy, fludrocortisone was added, correcting the hyperkalemia and allowing indomethacin therapy to be continued safely.	fludrocortisone	hyperkalemia	3375885	-1
-Only a handful of cases of ATRA-induced myositis in children have been reported, and none in the radiology literature.	ATRA	myositis	24658375	1
-Furthermore, Rg1 showed a tendency to aggravate OIH in the acetic acid-induced writhing test.	acetic acid	OIH	24709919	-1
-Furthermore, Rg1 showed a tendency to aggravate OIH in the acetic acid-induced writhing test.	Rg1	OIH	24709919	-1
-The data suggest that the dipyridamole-induced myocardial ischemia is caused by the inhomogenous distribution of myocardial blood flow.	dipyridamole	myocardial ischemia	3746148	1
-RESULTS: Dermal exposure of rats to S-53482 at 300 mg/kg produced patterns of developmental toxicity similar to those resulting from oral exposure.	S-53482	developmental toxicity	24753331	-1
-Fourteen of 84 (17%) patients had symptoms and signs consistent with CYA cardiotoxicity within ten days of receiving 1 to 4 doses of CYA.	CYA	cardiotoxicity	3533179	-1
-Fourteen of 84 (17%) patients had symptoms and signs consistent with CYA cardiotoxicity within ten days of receiving 1 to 4 doses of CYA.	CYA	cardiotoxicity	3533179	-1
-In this study, neurocognitive outcomes and neuroradiologic evidence of leukoencephalopathy were compared in children treated with intense central nervous system (CNS)-directed therapy (P9605) versus those receiving fewer CNS-directed treatment days during intensive consolidation (P9201).	P9605	leukoencephalopathy	24345882	-1
-We describe a case of a patient with Staphylococcal IE who developed acute renal failure secondary to a segmental necrotising glomerulonephritis while being treated with rifampicin, and review the literature regarding this complication of rifampicin therapy.	rifampicin	IE	17879217	-1
-We describe a case of a patient with Staphylococcal IE who developed acute renal failure secondary to a segmental necrotising glomerulonephritis while being treated with rifampicin, and review the literature regarding this complication of rifampicin therapy.	rifampicin	acute renal failure	17879217	1
-We describe a case of a patient with Staphylococcal IE who developed acute renal failure secondary to a segmental necrotising glomerulonephritis while being treated with rifampicin, and review the literature regarding this complication of rifampicin therapy.	rifampicin	necrotising glomerulonephritis	17879217	1
-We describe a case of a patient with Staphylococcal IE who developed acute renal failure secondary to a segmental necrotising glomerulonephritis while being treated with rifampicin, and review the literature regarding this complication of rifampicin therapy.	rifampicin	IE	17879217	-1
-We describe a case of a patient with Staphylococcal IE who developed acute renal failure secondary to a segmental necrotising glomerulonephritis while being treated with rifampicin, and review the literature regarding this complication of rifampicin therapy.	rifampicin	acute renal failure	17879217	1
-We describe a case of a patient with Staphylococcal IE who developed acute renal failure secondary to a segmental necrotising glomerulonephritis while being treated with rifampicin, and review the literature regarding this complication of rifampicin therapy.	rifampicin	necrotising glomerulonephritis	17879217	1
-Sirolimus, a mammalian target of rapamycin inhibitor, has been implicated as playing a special role in posttransplant anemia.	Sirolimus	anemia	19553912	1
-She developed leucopenia after being treated with quetiapine.	quetiapine	leucopenia	25084821	-1
-In the seven men who completed six months on thalidomide, subclinical evidence of peripheral neuropathy was found in four before treatment, but in all seven at repeat testing.	thalidomide	peripheral neuropathy	12644816	1
-CONCLUSIONS: The prevalence of levodopa-induced dyskinesia in our patients was 44%.	levodopa	dyskinesia	23952588	1
-Optimal precurarizing dose of rocuronium to decrease fasciculation and myalgia following succinylcholine administration.	succinylcholine	fasciculation	25006369	1
-Optimal precurarizing dose of rocuronium to decrease fasciculation and myalgia following succinylcholine administration.	succinylcholine	myalgia	25006369	1
-Optimal precurarizing dose of rocuronium to decrease fasciculation and myalgia following succinylcholine administration.	rocuronium	fasciculation	25006369	-1
-Optimal precurarizing dose of rocuronium to decrease fasciculation and myalgia following succinylcholine administration.	rocuronium	myalgia	25006369	-1
-CAPD is inefficient in removing piperacillin, whereas hemodialysis can rapidly terminate the piperacillin-induced encephalopathy.	piperacillin	encephalopathy	17496739	-1
-CAPD is inefficient in removing piperacillin, whereas hemodialysis can rapidly terminate the piperacillin-induced encephalopathy.	piperacillin	encephalopathy	17496739	-1
-STUDY OBJECTIVE: Chest pain in the setting of cocaine use poses a diagnostic dilemma.	cocaine	Chest pain	11423811	1
-Dobutamine stress echocardiography (DSE) is a widely available and sensitive test for evaluating cardiac ischemia. Because of the theoretical concern regarding administration of dobutamine in the setting of cocaine use, we conducted a pilot study to assess the safety of DSE in emergency department patients with cocaine-associated chest pain. METHODS: A prospective case series was conducted in the intensive diagnostic and treatment unit in the ED of an urban tertiary-care teaching hospital.	cocaine	ischemia	11423811	-1
-Dobutamine stress echocardiography (DSE) is a widely available and sensitive test for evaluating cardiac ischemia. Because of the theoretical concern regarding administration of dobutamine in the setting of cocaine use, we conducted a pilot study to assess the safety of DSE in emergency department patients with cocaine-associated chest pain. METHODS: A prospective case series was conducted in the intensive diagnostic and treatment unit in the ED of an urban tertiary-care teaching hospital.	cocaine	ischemia	11423811	-1
-Dobutamine stress echocardiography (DSE) is a widely available and sensitive test for evaluating cardiac ischemia. Because of the theoretical concern regarding administration of dobutamine in the setting of cocaine use, we conducted a pilot study to assess the safety of DSE in emergency department patients with cocaine-associated chest pain. METHODS: A prospective case series was conducted in the intensive diagnostic and treatment unit in the ED of an urban tertiary-care teaching hospital.	cocaine	chest pain	11423811	1
-Dobutamine stress echocardiography (DSE) is a widely available and sensitive test for evaluating cardiac ischemia. Because of the theoretical concern regarding administration of dobutamine in the setting of cocaine use, we conducted a pilot study to assess the safety of DSE in emergency department patients with cocaine-associated chest pain. METHODS: A prospective case series was conducted in the intensive diagnostic and treatment unit in the ED of an urban tertiary-care teaching hospital.	Dobutamine	ischemia	11423811	-1
-Dobutamine stress echocardiography (DSE) is a widely available and sensitive test for evaluating cardiac ischemia. Because of the theoretical concern regarding administration of dobutamine in the setting of cocaine use, we conducted a pilot study to assess the safety of DSE in emergency department patients with cocaine-associated chest pain. METHODS: A prospective case series was conducted in the intensive diagnostic and treatment unit in the ED of an urban tertiary-care teaching hospital.	Dobutamine	chest pain	11423811	-1
-Dobutamine stress echocardiography (DSE) is a widely available and sensitive test for evaluating cardiac ischemia. Because of the theoretical concern regarding administration of dobutamine in the setting of cocaine use, we conducted a pilot study to assess the safety of DSE in emergency department patients with cocaine-associated chest pain. METHODS: A prospective case series was conducted in the intensive diagnostic and treatment unit in the ED of an urban tertiary-care teaching hospital.	dobutamine	ischemia	11423811	-1
-Dobutamine stress echocardiography (DSE) is a widely available and sensitive test for evaluating cardiac ischemia. Because of the theoretical concern regarding administration of dobutamine in the setting of cocaine use, we conducted a pilot study to assess the safety of DSE in emergency department patients with cocaine-associated chest pain. METHODS: A prospective case series was conducted in the intensive diagnostic and treatment unit in the ED of an urban tertiary-care teaching hospital.	dobutamine	chest pain	11423811	-1
-Patients were eligible for DSE if they had used cocaine within 24 hours preceding the onset of chest pain and had a normal ECG and tropinin I level.	cocaine	chest pain	11423811	1
-Patients exhibiting signs of continuing cocaine toxicity were excluded from the study.	cocaine	toxicity	11423811	-1
-Seventy percent of rats given 250 ppm quinacrine hydrochloride and 1,000 ppm sodium nitrite simultaneously in the diet had thrombosis of the atria of the heart, while untreated control rats in this laboratory did not have atrial thrombosis.	quinacrine hydrochloride	thrombosis	6517710	-1
-Seventy percent of rats given 250 ppm quinacrine hydrochloride and 1,000 ppm sodium nitrite simultaneously in the diet had thrombosis of the atria of the heart, while untreated control rats in this laboratory did not have atrial thrombosis.	quinacrine hydrochloride	atrial thrombosis	6517710	-1
-Seventy percent of rats given 250 ppm quinacrine hydrochloride and 1,000 ppm sodium nitrite simultaneously in the diet had thrombosis of the atria of the heart, while untreated control rats in this laboratory did not have atrial thrombosis.	sodium nitrite	thrombosis	6517710	-1
-Seventy percent of rats given 250 ppm quinacrine hydrochloride and 1,000 ppm sodium nitrite simultaneously in the diet had thrombosis of the atria of the heart, while untreated control rats in this laboratory did not have atrial thrombosis.	sodium nitrite	atrial thrombosis	6517710	-1
-RESULTS: All five patients experienced symptoms of encephalopathy soon after (within 12 h-2 days) receiving ifosfamide.	ifosfamide	encephalopathy	24209900	-1
-The risk of VNR cardiac events was similar to vindesine (VDS) and other cardiotoxic drugs [fluorouracil, anthracyclines, gemcitabine (GEM) em leader ].	anthracyclines	cardiotoxic	14748761	-1
-The risk of VNR cardiac events was similar to vindesine (VDS) and other cardiotoxic drugs [fluorouracil, anthracyclines, gemcitabine (GEM) em leader ].	VNR	cardiotoxic	14748761	1
-The risk of VNR cardiac events was similar to vindesine (VDS) and other cardiotoxic drugs [fluorouracil, anthracyclines, gemcitabine (GEM) em leader ].	vindesine	cardiotoxic	14748761	-1
-The risk of VNR cardiac events was similar to vindesine (VDS) and other cardiotoxic drugs [fluorouracil, anthracyclines, gemcitabine (GEM) em leader ].	VDS	cardiotoxic	14748761	-1
-The risk of VNR cardiac events was similar to vindesine (VDS) and other cardiotoxic drugs [fluorouracil, anthracyclines, gemcitabine (GEM) em leader ].	fluorouracil	cardiotoxic	14748761	-1
-The risk of VNR cardiac events was similar to vindesine (VDS) and other cardiotoxic drugs [fluorouracil, anthracyclines, gemcitabine (GEM) em leader ].	gemcitabine	cardiotoxic	14748761	-1
-The risk of VNR cardiac events was similar to vindesine (VDS) and other cardiotoxic drugs [fluorouracil, anthracyclines, gemcitabine (GEM) em leader ].	GEM	cardiotoxic	14748761	-1
-Two cases of propylthiouracil-induced liver damage have been observed.	propylthiouracil	liver damage	6893265	1
-Chronic administration of LF strongly reduced the blood pressure and production of ROS and improved antioxidant capacity in Dex-induced hypertension, suggesting the role of inhibition of oxidative stress as another mechanism of antihypertensive action of LF.	Dex	hypertension	24587916	1
-Chronic administration of LF strongly reduced the blood pressure and production of ROS and improved antioxidant capacity in Dex-induced hypertension, suggesting the role of inhibition of oxidative stress as another mechanism of antihypertensive action of LF.	Dex	LF	24587916	-1
-Chronic administration of LF strongly reduced the blood pressure and production of ROS and improved antioxidant capacity in Dex-induced hypertension, suggesting the role of inhibition of oxidative stress as another mechanism of antihypertensive action of LF.	Dex	LF	24587916	-1
-Increasing recognition of the importance of calcium in the pathogenesis of cardiovascular disease has stimulated research into the use of calcium channel blocking agents for treatment of a variety of cardiovascular diseases.	calcium	cardiovascular disease	3323259	-1
-Increasing recognition of the importance of calcium in the pathogenesis of cardiovascular disease has stimulated research into the use of calcium channel blocking agents for treatment of a variety of cardiovascular diseases.	calcium	cardiovascular diseases	3323259	-1
-Increasing recognition of the importance of calcium in the pathogenesis of cardiovascular disease has stimulated research into the use of calcium channel blocking agents for treatment of a variety of cardiovascular diseases.	calcium	cardiovascular disease	3323259	-1
-Increasing recognition of the importance of calcium in the pathogenesis of cardiovascular disease has stimulated research into the use of calcium channel blocking agents for treatment of a variety of cardiovascular diseases.	calcium	cardiovascular diseases	3323259	-1
-Therefore, it is suggested that the administration of PS enhances the toxicity of AMNS on the glomerulus and readily produces progressive FSGS in rats resulting in the end-stage renal disease.	AMNS	toxicity	3323599	-1
-Therefore, it is suggested that the administration of PS enhances the toxicity of AMNS on the glomerulus and readily produces progressive FSGS in rats resulting in the end-stage renal disease.	AMNS	end-stage renal disease	3323599	1
-Therefore, it is suggested that the administration of PS enhances the toxicity of AMNS on the glomerulus and readily produces progressive FSGS in rats resulting in the end-stage renal disease.	PS	toxicity	3323599	-1
-Therefore, it is suggested that the administration of PS enhances the toxicity of AMNS on the glomerulus and readily produces progressive FSGS in rats resulting in the end-stage renal disease.	PS	end-stage renal disease	3323599	-1
-In some cases, a high serum concentration of citalopram (> 600 nmol/L) in elderly patients has been associated with increased somnolence and movement difficulties.	citalopram	somnolence	8312983	-1
-It is unclear whether a coronary CTA strategy would be efficacious in cocaine-associated chest pain, as coronary vasospasm may account for some of the ischemia.	cocaine	ischemia	19655282	-1
-It is unclear whether a coronary CTA strategy would be efficacious in cocaine-associated chest pain, as coronary vasospasm may account for some of the ischemia.	cocaine	chest pain	19655282	1
-It is unclear whether a coronary CTA strategy would be efficacious in cocaine-associated chest pain, as coronary vasospasm may account for some of the ischemia.	cocaine	coronary vasospasm	19655282	-1
-0.4) compared with cardiac mitochondria isolated from saline-treated rats. Mitochondrial calcium-loading capacity and the activity of NADH-dehydrogenase were also suppressed in cardiac mitochondria from doxorubicin-treated rats.	doxorubicin	cardiac mitochondria	12498738	-1
-0.4) compared with cardiac mitochondria isolated from saline-treated rats. Mitochondrial calcium-loading capacity and the activity of NADH-dehydrogenase were also suppressed in cardiac mitochondria from doxorubicin-treated rats.	doxorubicin	cardiac mitochondria	12498738	-1
-0.4) compared with cardiac mitochondria isolated from saline-treated rats. Mitochondrial calcium-loading capacity and the activity of NADH-dehydrogenase were also suppressed in cardiac mitochondria from doxorubicin-treated rats.	calcium	cardiac mitochondria	12498738	-1
-0.4) compared with cardiac mitochondria isolated from saline-treated rats. Mitochondrial calcium-loading capacity and the activity of NADH-dehydrogenase were also suppressed in cardiac mitochondria from doxorubicin-treated rats.	calcium	cardiac mitochondria	12498738	-1
-As this schedule exerted more toxicity than needed to investigate protective agents, the protection of ICRF-187 was determined using a dose schedule with lower general toxicity (6 weekly doses of 4 mg/kg doxorubicin given i.v. plus	doxorubicin	toxicity	8603459	-1
-As this schedule exerted more toxicity than needed to investigate protective agents, the protection of ICRF-187 was determined using a dose schedule with lower general toxicity (6 weekly doses of 4 mg/kg doxorubicin given i.v. plus	doxorubicin	toxicity	8603459	-1
-As this schedule exerted more toxicity than needed to investigate protective agents, the protection of ICRF-187 was determined using a dose schedule with lower general toxicity (6 weekly doses of 4 mg/kg doxorubicin given i.v. plus	ICRF-187	toxicity	8603459	-1
-As this schedule exerted more toxicity than needed to investigate protective agents, the protection of ICRF-187 was determined using a dose schedule with lower general toxicity (6 weekly doses of 4 mg/kg doxorubicin given i.v. plus	ICRF-187	toxicity	8603459	-1
-Acetaminophen (APAP) produces proximal tubular necrosis in Fischer 344 (F344) rats.	Acetaminophen	tubular necrosis	4082192	-1
-Acetaminophen (APAP) produces proximal tubular necrosis in Fischer 344 (F344) rats.	APAP	tubular necrosis	4082192	-1
-Doxorubicin treatment also caused a decrease in RCR for liver mitochondria (3.9 +/-	Doxorubicin	liver mitochondria	12498738	-1
-This is the first published report documenting the preferential in vivo binding of estrogen to nuclei of cells in estrogen induced hamster renal carcinomas.	estrogen	hamster renal carcinomas	2650911	-1
-This is the first published report documenting the preferential in vivo binding of estrogen to nuclei of cells in estrogen induced hamster renal carcinomas.	estrogen	hamster renal carcinomas	2650911	-1
-Although both dl-sotalol and azimilide rarely induced EADs in canine left ventricles, they produced frequent EADs in rabbits, in which more pronounced QT prolongation was seen.	azimilide	QT prolongation	11401944	-1
-Tolerability of lomustine in combination with cyclophosphamide in dogs with lymphoma.	cyclophosphamide	lymphoma	24659727	-1
-Tolerability of lomustine in combination with cyclophosphamide in dogs with lymphoma.	lomustine	lymphoma	24659727	-1
-Cardioprotective effect of ethanolic extract of Terminalia chebula fruits (500 mg/kg body wt) was examined in isoproterenol (200 mg/kg body wt) induced myocardial damage in rats.	isoproterenol	myocardial damage	15282950	1
-Carvedilol by itself did not affect any of the parameters measured for heart or liver mitochondria.	Carvedilol	liver mitochondria	12498738	-1
-It is concluded that this protection by carvedilol against both the structural and functional cardiac tissue damage may afford significant clinical advantage in minimizing the dose-limiting mitochondrial dysfunction and cardiomyopathy that accompanies long-term doxorubicin therapy in cancer patients.	doxorubicin	cardiomyopathy	12498738	1
-It is concluded that this protection by carvedilol against both the structural and functional cardiac tissue damage may afford significant clinical advantage in minimizing the dose-limiting mitochondrial dysfunction and cardiomyopathy that accompanies long-term doxorubicin therapy in cancer patients.	doxorubicin	cancer	12498738	-1
-It is concluded that this protection by carvedilol against both the structural and functional cardiac tissue damage may afford significant clinical advantage in minimizing the dose-limiting mitochondrial dysfunction and cardiomyopathy that accompanies long-term doxorubicin therapy in cancer patients.	doxorubicin	mitochondrial dysfunction	12498738	-1
-It is concluded that this protection by carvedilol against both the structural and functional cardiac tissue damage may afford significant clinical advantage in minimizing the dose-limiting mitochondrial dysfunction and cardiomyopathy that accompanies long-term doxorubicin therapy in cancer patients.	carvedilol	cardiomyopathy	12498738	-1
-It is concluded that this protection by carvedilol against both the structural and functional cardiac tissue damage may afford significant clinical advantage in minimizing the dose-limiting mitochondrial dysfunction and cardiomyopathy that accompanies long-term doxorubicin therapy in cancer patients.	carvedilol	cancer	12498738	-1
-It is concluded that this protection by carvedilol against both the structural and functional cardiac tissue damage may afford significant clinical advantage in minimizing the dose-limiting mitochondrial dysfunction and cardiomyopathy that accompanies long-term doxorubicin therapy in cancer patients.	carvedilol	mitochondrial dysfunction	12498738	-1
-Propranolol antagonism of phenylpropanolamine-induced hypertension.	phenylpropanolamine	hypertension	3987172	1
-Propranolol antagonism of phenylpropanolamine-induced hypertension.	Propranolol	hypertension	3987172	-1
-Studies of human subjects who have used MA chronically have revealed deficits in dopaminergic and serotonergic systems and cerebral metabolic abnormalities.	MA	deficits	15229250	-1
-Studies of human subjects who have used MA chronically have revealed deficits in dopaminergic and serotonergic systems and cerebral metabolic abnormalities.	MA	cerebral metabolic abnormalities	15229250	-1
-The results warrant clinical trials of denopamine in the treatment of cardiac failure.	denopamine	cardiac failure	3831029	-1
-Infants were assigned to the cocaine-exposed group if there was a maternal history of cocaine abuse during pregnancy or if maternal or neonatal urine toxicology results were positive at the time of delivery.	cocaine	abuse	11425091	-1
-Infants were assigned to the cocaine-exposed group if there was a maternal history of cocaine abuse during pregnancy or if maternal or neonatal urine toxicology results were positive at the time of delivery.	cocaine	abuse	11425091	-1
-RESULTS: In a pooled analysis of 1460 ICH and 3817 IS/TIA, MB were more frequent in ICH vs IS/TIA in all treatment groups, but the excess increased from 2.8 (odds ratio; range, 2.3-3.5) in nonantithrombotic users to 5.7 (range, 3.4-9.7) in antiplatelet users and 8.0 (range, 3.5-17.8) in warfarin users (P difference=0.01).	warfarin	IS	20431083	-1
-RESULTS: In a pooled analysis of 1460 ICH and 3817 IS/TIA, MB were more frequent in ICH vs IS/TIA in all treatment groups, but the excess increased from 2.8 (odds ratio; range, 2.3-3.5) in nonantithrombotic users to 5.7 (range, 3.4-9.7) in antiplatelet users and 8.0 (range, 3.5-17.8) in warfarin users (P difference=0.01).	warfarin	IS	20431083	-1
-RESULTS: In a pooled analysis of 1460 ICH and 3817 IS/TIA, MB were more frequent in ICH vs IS/TIA in all treatment groups, but the excess increased from 2.8 (odds ratio; range, 2.3-3.5) in nonantithrombotic users to 5.7 (range, 3.4-9.7) in antiplatelet users and 8.0 (range, 3.5-17.8) in warfarin users (P difference=0.01).	warfarin	TIA	20431083	-1
-RESULTS: In a pooled analysis of 1460 ICH and 3817 IS/TIA, MB were more frequent in ICH vs IS/TIA in all treatment groups, but the excess increased from 2.8 (odds ratio; range, 2.3-3.5) in nonantithrombotic users to 5.7 (range, 3.4-9.7) in antiplatelet users and 8.0 (range, 3.5-17.8) in warfarin users (P difference=0.01).	warfarin	TIA	20431083	-1
-RESULTS: In a pooled analysis of 1460 ICH and 3817 IS/TIA, MB were more frequent in ICH vs IS/TIA in all treatment groups, but the excess increased from 2.8 (odds ratio; range, 2.3-3.5) in nonantithrombotic users to 5.7 (range, 3.4-9.7) in antiplatelet users and 8.0 (range, 3.5-17.8) in warfarin users (P difference=0.01).	warfarin	ICH	20431083	1
-CONCLUSIONS: Initiating treatment of type 2 diabetes with glibenclamide or glipizide is associated with increased risk of CAD in comparison to gliclazide or glimepiride.	glibenclamide	diabetes	18945509	-1
-CONCLUSIONS: Initiating treatment of type 2 diabetes with glibenclamide or glipizide is associated with increased risk of CAD in comparison to gliclazide or glimepiride.	glipizide	CAD	18945509	-1
-CONCLUSIONS: Initiating treatment of type 2 diabetes with glibenclamide or glipizide is associated with increased risk of CAD in comparison to gliclazide or glimepiride.	glipizide	diabetes	18945509	-1
-CONCLUSIONS: Initiating treatment of type 2 diabetes with glibenclamide or glipizide is associated with increased risk of CAD in comparison to gliclazide or glimepiride.	gliclazide	CAD	18945509	-1
-CONCLUSIONS: Initiating treatment of type 2 diabetes with glibenclamide or glipizide is associated with increased risk of CAD in comparison to gliclazide or glimepiride.	gliclazide	diabetes	18945509	-1
-CONCLUSIONS: Initiating treatment of type 2 diabetes with glibenclamide or glipizide is associated with increased risk of CAD in comparison to gliclazide or glimepiride.	glimepiride	CAD	18945509	-1
-CONCLUSIONS: Initiating treatment of type 2 diabetes with glibenclamide or glipizide is associated with increased risk of CAD in comparison to gliclazide or glimepiride.	glimepiride	diabetes	18945509	-1
-Hepatic dysfunction may be one of the possible risk factors, and concomitant fever may be a diagnostic marker for adverse reaction to quetiapine.	quetiapine	Hepatic dysfunction	25084821	-1
-Hydroxytyrosol improved the cardiac disturbances enhanced by doxorubicin by significantly reducing the percentage of altered mitochondria and oxidative damage.	doxorubicin	cardiac disturbances	24727461	1
-Hydroxytyrosol improved the cardiac disturbances enhanced by doxorubicin by significantly reducing the percentage of altered mitochondria and oxidative damage.	Hydroxytyrosol	cardiac disturbances	24727461	-1
-Using magnetic resonance imaging (MRI) and new computational brain-mapping techniques, we determined the pattern of structural brain alterations associated with chronic MA abuse in human subjects and related these deficits to cognitive impairment.	MA	deficits	15229250	-1
-Using magnetic resonance imaging (MRI) and new computational brain-mapping techniques, we determined the pattern of structural brain alterations associated with chronic MA abuse in human subjects and related these deficits to cognitive impairment.	MA	cognitive impairment	15229250	-1
-AIMS: To investigate whether alterations of myocardial strain and high-sensitive cardiac troponin T (cTnT) could predict future cardiac dysfunction in patients after epirubicin exposure.	epirubicin	cardiac dysfunction	24464946	-1
-We report a case about a female with essential hypertension on drug treatment with amlodipine developed loss of taste sensation.	amlodipine	hypertension	25031906	-1
-We report a case about a female with essential hypertension on drug treatment with amlodipine developed loss of taste sensation.	amlodipine	loss of taste sensation	25031906	-1
-The present study was designed to investigate the effect of 5 non-steroidal anti-inflammatory drugs, sodium salicylate, phenylbutazone, indomethacin, ibuprofen and mefenamic acid, on seizures produced by pilocarpine.	mefenamic acid	seizures	3191389	-1
-The present study was designed to investigate the effect of 5 non-steroidal anti-inflammatory drugs, sodium salicylate, phenylbutazone, indomethacin, ibuprofen and mefenamic acid, on seizures produced by pilocarpine.	phenylbutazone	seizures	3191389	1
-The present study was designed to investigate the effect of 5 non-steroidal anti-inflammatory drugs, sodium salicylate, phenylbutazone, indomethacin, ibuprofen and mefenamic acid, on seizures produced by pilocarpine.	ibuprofen	seizures	3191389	-1
-The present study was designed to investigate the effect of 5 non-steroidal anti-inflammatory drugs, sodium salicylate, phenylbutazone, indomethacin, ibuprofen and mefenamic acid, on seizures produced by pilocarpine.	indomethacin	seizures	3191389	-1
-This review considers anemia associated with sirolimus, including its presentation, mechanisms, and management.	sirolimus	anemia	19553912	1
-There was also an excess of MB in warfarin users vs nonusers with ICH (OR, 2.7; 95% CI, 1.6-4.4; P<0.001) but none in warfarin users with IS/TIA (OR, 1.3; 95% CI, 0.9-1.7; P=0.33; P difference=0.01).	warfarin	IS	20431083	-1
-There was also an excess of MB in warfarin users vs nonusers with ICH (OR, 2.7; 95% CI, 1.6-4.4; P<0.001) but none in warfarin users with IS/TIA (OR, 1.3; 95% CI, 0.9-1.7; P=0.33; P difference=0.01).	warfarin	TIA	20431083	-1
-There was also an excess of MB in warfarin users vs nonusers with ICH (OR, 2.7; 95% CI, 1.6-4.4; P<0.001) but none in warfarin users with IS/TIA (OR, 1.3; 95% CI, 0.9-1.7; P=0.33; P difference=0.01).	warfarin	IS	20431083	-1
-There was also an excess of MB in warfarin users vs nonusers with ICH (OR, 2.7; 95% CI, 1.6-4.4; P<0.001) but none in warfarin users with IS/TIA (OR, 1.3; 95% CI, 0.9-1.7; P=0.33; P difference=0.01).	warfarin	TIA	20431083	-1
-There was also an excess of MB in warfarin users vs nonusers with ICH (OR, 2.7; 95% CI, 1.6-4.4; P<0.001) but none in warfarin users with IS/TIA (OR, 1.3; 95% CI, 0.9-1.7; P=0.33; P difference=0.01).	warfarin	ICH	20431083	1
-Acute hepatitis associated with clopidogrel: a case report and review of the literature.	clopidogrel	hepatitis	23846525	1
-Does domperidone potentiate mirtazapine-associated restless legs syndrome?	domperidone potentiate mirtazapine	restless legs syndrome	16309808	1
-Glial activation and post-synaptic neurotoxicity: the key events in Streptozotocin (ICV) induced memory impairment in rats.	Streptozotocin	memory impairment	24333387	1
-Glial activation and post-synaptic neurotoxicity: the key events in Streptozotocin (ICV) induced memory impairment in rats.	Streptozotocin	neurotoxicity	24333387	-1
-Long-term efficacy and adverse event of nifedipine sustained-release tablets for cyclosporin A-induced hypertension in patients with psoriasis.	nifedipine	hypertension	9889429	-1
-Long-term efficacy and adverse event of nifedipine sustained-release tablets for cyclosporin A-induced hypertension in patients with psoriasis.	nifedipine	psoriasis	9889429	-1
-Long-term efficacy and adverse event of nifedipine sustained-release tablets for cyclosporin A-induced hypertension in patients with psoriasis.	cyclosporin A	psoriasis	9889429	-1
-The treatment regimens are described in 74 patients with endometrial disease among 850 climacteric women receiving oestrogen therapy.	oestrogen	endometrial disease	89511	-1
-To our knowledge, there is no previous report regarding whether domperidone, a peripheral dopamine D2 receptor antagonist, can also induce or aggravate symptoms of RLS.	dopamine	RLS	16309808	-1
-To our knowledge, there is no previous report regarding whether domperidone, a peripheral dopamine D2 receptor antagonist, can also induce or aggravate symptoms of RLS.	domperidone	RLS	16309808	-1
-Left ventricular function (assessed by echocardiography) showed that PPA increased the stroke volume 30% (from 62.5 +/-	PPA	stroke	3987172	-1
-Mirtazapine, the first noradrenergic and specific serotonergic antidepressant (NaSSA), has been associated with RLS in several recent publications.	antidepressant	RLS	16309808	-1
-Mirtazapine, the first noradrenergic and specific serotonergic antidepressant (NaSSA), has been associated with RLS in several recent publications.	NaSSA	RLS	16309808	-1
-Mirtazapine, the first noradrenergic and specific serotonergic antidepressant (NaSSA), has been associated with RLS in several recent publications.	Mirtazapine	RLS	16309808	1
-For further reduction of HIT type II, the use of intravenous heparin should be avoided and the prophylactic anticoagulation should be performed with low-molecular-weight heparin after normalization of platelet count.	heparin	HIT	24100055	1
-For further reduction of HIT type II, the use of intravenous heparin should be avoided and the prophylactic anticoagulation should be performed with low-molecular-weight heparin after normalization of platelet count.	low-molecular-weight heparin	HIT	24100055	-1
-Renal failure is a rare complication associated with the use of rifampin.	rifampin	Renal failure	1522360	-1
-Intravascular hemolysis leading to acute renal failure following rifampin therapy is extremely rare.	rifampin	acute renal failure	1522360	1
-Intravascular hemolysis leading to acute renal failure following rifampin therapy is extremely rare.	rifampin	hemolysis	1522360	1
-Our analysis suggests that those patients receiving the dosing schedule of 100 mg/m(2) cisplatin every 3 weeks and those with hypertension are at the greatest risk of nephrotoxicity and would benefit from the addition of mannitol.	mannitol	hypertension	24778426	-1
-Our analysis suggests that those patients receiving the dosing schedule of 100 mg/m(2) cisplatin every 3 weeks and those with hypertension are at the greatest risk of nephrotoxicity and would benefit from the addition of mannitol.	mannitol	nephrotoxicity	24778426	-1
-Our analysis suggests that those patients receiving the dosing schedule of 100 mg/m(2) cisplatin every 3 weeks and those with hypertension are at the greatest risk of nephrotoxicity and would benefit from the addition of mannitol.	cisplatin	hypertension	24778426	-1
-Our analysis suggests that those patients receiving the dosing schedule of 100 mg/m(2) cisplatin every 3 weeks and those with hypertension are at the greatest risk of nephrotoxicity and would benefit from the addition of mannitol.	cisplatin	nephrotoxicity	24778426	-1
-Two patients with leprosy who developed hemolysis and acute renal failure following rifampin are reported.	rifampin	leprosy	1522360	-1
-Two patients with leprosy who developed hemolysis and acute renal failure following rifampin are reported.	rifampin	hemolysis	1522360	1
-A 47-year-old woman with right hydroureteronephrosis due to ureterovesical junction obstruction had gross hematuria after being treated for five years wtih cyclophosphamide for cerebral vasculitis.	cyclophosphamide	cerebral vasculitis	7248895	-1
-A 47-year-old woman with right hydroureteronephrosis due to ureterovesical junction obstruction had gross hematuria after being treated for five years wtih cyclophosphamide for cerebral vasculitis.	cyclophosphamide	right hydroureteronephrosis	7248895	-1
-A 47-year-old woman with right hydroureteronephrosis due to ureterovesical junction obstruction had gross hematuria after being treated for five years wtih cyclophosphamide for cerebral vasculitis.	cyclophosphamide	hematuria	7248895	1
-CONCLUSION: Flumazenil can unmask seizures and increase the incidence of death in a model of combined cocaine-diazepam intoxications.	cocaine-diazepam	death	8135424	-1
-CONCLUSION: Flumazenil can unmask seizures and increase the incidence of death in a model of combined cocaine-diazepam intoxications.	Flumazenil	death	8135424	-1
-Post-training administration of naloxone (3 mg/kg) as a single or as a split dose also attenuated the scopolamine-induced amnesia.	naloxone	amnesia	3088653	-1
-CONCLUSION: Only one hypersensitivity reaction to CE was documented among 9 P and N-highly NSAIDs intolerant patients.	CE	hypersensitivity	15859361	-1
-CONCLUSION: Only one hypersensitivity reaction to CE was documented among 9 P and N-highly NSAIDs intolerant patients.	N	hypersensitivity	15859361	-1
-Oxitropium proves to be a valuable alternative to theophylline in nocturnal asthma, since it is equally potent, safer and does not require the titration of dosage.	theophylline	nocturnal asthma	3074291	-1
-Oxitropium proves to be a valuable alternative to theophylline in nocturnal asthma, since it is equally potent, safer and does not require the titration of dosage.	Oxitropium	nocturnal asthma	3074291	-1
-The effectiveness of PTRA on renal function seems to be barely influenced by CM toxicity.	CM	toxicity	20192893	-1
-The effectiveness of PTRA on renal function seems to be barely influenced by CM toxicity.	PTRA	toxicity	20192893	-1
-A group of doctors in Boston warn that the protease inhibitor Viracept may cause an irregular heart beat, known as bradycardia, in people with HIV.	Viracept	bradycardia	11366874	1
-Kaliuretic effect of L-dopa treatment in parkinsonian patients.	L-dopa	parkinsonian	851038	-1
-Oral pre-treatment with PK (80 mg kg(-1) day(-1) for 15 days) significantly prevented the isoproterenol-induced myocardial infarction and maintained the rats at near normal status.	PK	myocardial infarction	11395263	-1
-We report a newborn infant with multiple congenital anomalies (anotia and Taussig-Bing malformation) due to exposure to isotretinoin within the first trimester.	isotretinoin	multiple congenital anomalies	11105626	-1
-We report a newborn infant with multiple congenital anomalies (anotia and Taussig-Bing malformation) due to exposure to isotretinoin within the first trimester.	isotretinoin	malformation	11105626	-1
-We report a newborn infant with multiple congenital anomalies (anotia and Taussig-Bing malformation) due to exposure to isotretinoin within the first trimester.	isotretinoin	anotia	11105626	1
-This case demonstrates the selective vulnerability of the anterior visual pathways and peripheral nerves to ethambutol toxicity.	ethambutol	toxicity	24897009	-1
-Structural abnormalities in the brains of human subjects who use methamphetamine.	methamphetamine	Structural abnormalities	15229250	-1
-We herein describe the case of an 81-year-old Japanese woman with neuroleptic malignant syndrome that occurred 36 days after the initiation of combination therapy with tiapride (75 mg/day) and tetrabenazine (12.5 mg/day) for Huntington's disease.	tiapride	Huntington's disease	24881749	-1
-We herein describe the case of an 81-year-old Japanese woman with neuroleptic malignant syndrome that occurred 36 days after the initiation of combination therapy with tiapride (75 mg/day) and tetrabenazine (12.5 mg/day) for Huntington's disease.	tiapride	neuroleptic malignant syndrome	24881749	1
-We herein describe the case of an 81-year-old Japanese woman with neuroleptic malignant syndrome that occurred 36 days after the initiation of combination therapy with tiapride (75 mg/day) and tetrabenazine (12.5 mg/day) for Huntington's disease.	tetrabenazine	Huntington's disease	24881749	-1
-We herein describe the case of an 81-year-old Japanese woman with neuroleptic malignant syndrome that occurred 36 days after the initiation of combination therapy with tiapride (75 mg/day) and tetrabenazine (12.5 mg/day) for Huntington's disease.	tetrabenazine	neuroleptic malignant syndrome	24881749	1
-Reversible valproic acid-induced dementia: a case report.	valproic acid	dementia	3084231	1
-Delirium during fluoxetine treatment.	fluoxetine	Delirium	8312983	1
-MATERIALS AND METHODS: We studied with a 2.5 years follow-up the changes in plasma cholesterols (C), triglycerides (TG), lipoproteins (LP), and apolipoproteins (Apo) B-100, A-I, and A-II pro fi les in 24 patients of mean age 60 years with low risk prostate cancer (stage: T1cN0M0, Gleason score: 2-5) during treatment with cyproterone acetate (CPA) without surgical management or radiation therapy.	triglycerides	prostate cancer	16323982	-1
-MATERIALS AND METHODS: We studied with a 2.5 years follow-up the changes in plasma cholesterols (C), triglycerides (TG), lipoproteins (LP), and apolipoproteins (Apo) B-100, A-I, and A-II pro fi les in 24 patients of mean age 60 years with low risk prostate cancer (stage: T1cN0M0, Gleason score: 2-5) during treatment with cyproterone acetate (CPA) without surgical management or radiation therapy.	TG	prostate cancer	16323982	-1
-MATERIALS AND METHODS: We studied with a 2.5 years follow-up the changes in plasma cholesterols (C), triglycerides (TG), lipoproteins (LP), and apolipoproteins (Apo) B-100, A-I, and A-II pro fi les in 24 patients of mean age 60 years with low risk prostate cancer (stage: T1cN0M0, Gleason score: 2-5) during treatment with cyproterone acetate (CPA) without surgical management or radiation therapy.	cyproterone acetate	prostate cancer	16323982	-1
-MATERIALS AND METHODS: We studied with a 2.5 years follow-up the changes in plasma cholesterols (C), triglycerides (TG), lipoproteins (LP), and apolipoproteins (Apo) B-100, A-I, and A-II pro fi les in 24 patients of mean age 60 years with low risk prostate cancer (stage: T1cN0M0, Gleason score: 2-5) during treatment with cyproterone acetate (CPA) without surgical management or radiation therapy.	CPA	prostate cancer	16323982	-1
-MATERIALS AND METHODS: We studied with a 2.5 years follow-up the changes in plasma cholesterols (C), triglycerides (TG), lipoproteins (LP), and apolipoproteins (Apo) B-100, A-I, and A-II pro fi les in 24 patients of mean age 60 years with low risk prostate cancer (stage: T1cN0M0, Gleason score: 2-5) during treatment with cyproterone acetate (CPA) without surgical management or radiation therapy.	cholesterols	prostate cancer	16323982	-1
-MATERIALS AND METHODS: We studied with a 2.5 years follow-up the changes in plasma cholesterols (C), triglycerides (TG), lipoproteins (LP), and apolipoproteins (Apo) B-100, A-I, and A-II pro fi les in 24 patients of mean age 60 years with low risk prostate cancer (stage: T1cN0M0, Gleason score: 2-5) during treatment with cyproterone acetate (CPA) without surgical management or radiation therapy.	C	prostate cancer	16323982	-1
-The hyperactivity induced by D-amphetamine (10 mumol/kg) was significantly reduced by DSP4 pretreatment.	D-amphetamine	hyperactivity	6687006	-1
-Blocking studies using receptor for AGE siRNA and a specific inhibitor of Smad3 (SIS3) were performed in MMECs and in STZ-induced diabetic nephropathy in Tie2-Cre;Loxp-EGFP mice.	STZ	diabetic nephropathy	20682692	1
-After a period of 2.5 years on CPA treatment, four patients out of twenty-four were found to be affected by coronary heart disease.	CPA	coronary heart disease	16323982	-1
-CONCLUSION: This report describes the case of a woman with LACNP that developed after a steroid injection for the treatment of lateral epicondylitis.	steroid	lateral epicondylitis	25096313	-1
-CONCLUSIONS: Ischaemic coronary arteriosclerosis with an incidence rate of 16.6% as caused by prolonged CPA therapy is mediated through changes in HDL cholesterol, Apo A-I and Apo A-II pro fi les, other than the well-known hyperglyceridemic effect caused by estrogen.	cholesterol	Ischaemic coronary arteriosclerosis	16323982	-1
-CONCLUSIONS: Ischaemic coronary arteriosclerosis with an incidence rate of 16.6% as caused by prolonged CPA therapy is mediated through changes in HDL cholesterol, Apo A-I and Apo A-II pro fi les, other than the well-known hyperglyceridemic effect caused by estrogen.	CPA	Ischaemic coronary arteriosclerosis	16323982	1
-CONCLUSIONS: Ischaemic coronary arteriosclerosis with an incidence rate of 16.6% as caused by prolonged CPA therapy is mediated through changes in HDL cholesterol, Apo A-I and Apo A-II pro fi les, other than the well-known hyperglyceridemic effect caused by estrogen.	estrogen	Ischaemic coronary arteriosclerosis	16323982	-1
-Cortical maps revealed severe gray-matter deficits in the cingulate, limbic, and paralimbic cortices of MA abusers (averaging 11.3% below control; p < 0.05).	MA	gray-matter deficits	15229250	-1
-In the present study, the effect of chronic pre-treatment with metformin on cardiac dysfunction and toll-like receptor 4 (TLR4) activities following myocardial infarction and their relation with AMPK were assessed.	metformin	myocardial infarction	24842192	-1
-In the present study, the effect of chronic pre-treatment with metformin on cardiac dysfunction and toll-like receptor 4 (TLR4) activities following myocardial infarction and their relation with AMPK were assessed.	metformin	cardiac dysfunction	24842192	-1
-In the present study, the effect of chronic pre-treatment with metformin on cardiac dysfunction and toll-like receptor 4 (TLR4) activities following myocardial infarction and their relation with AMPK were assessed.	AMPK	myocardial infarction	24842192	-1
-In the present study, the effect of chronic pre-treatment with metformin on cardiac dysfunction and toll-like receptor 4 (TLR4) activities following myocardial infarction and their relation with AMPK were assessed.	AMPK	cardiac dysfunction	24842192	-1
-CONCLUSIONS: The excess of MB in warfarin users with ICH compared to other groups suggests that MB increase the risk of warfarin-associated ICH.	warfarin	ICH	20431083	1
-CONCLUSIONS: The excess of MB in warfarin users with ICH compared to other groups suggests that MB increase the risk of warfarin-associated ICH.	warfarin	ICH	20431083	1
-We have studied the effects of oral treatment with eslicarbazepine acetate on a whole-animal model in which partial seizures can be elicited repeatedly on different days without changes in threshold or seizure patterns.	eslicarbazepine acetate	seizures	16920333	-1
-We have studied the effects of oral treatment with eslicarbazepine acetate on a whole-animal model in which partial seizures can be elicited repeatedly on different days without changes in threshold or seizure patterns.	eslicarbazepine acetate	seizure	16920333	-1
-Reversible valproic acid-induced dementia was documented in a 21-year-old man with epilepsy who had a 3-year history of insidious progressive decline in global cognitive abilities documented by serial neuropsychological studies.	valproic acid	dementia	3084231	1
-Reversible valproic acid-induced dementia was documented in a 21-year-old man with epilepsy who had a 3-year history of insidious progressive decline in global cognitive abilities documented by serial neuropsychological studies.	valproic acid	epilepsy	3084231	-1
-Intravenous or intratracheal inoculation of 2.0 to 2.5 mg of vincristine sulfate was followed by leukopenia in 4 to 5 days.	vincristine sulfate	leukopenia	4631913	1
-We did a cohort analysis to estimate and compare incidence of VTE in users of the main OC preparations, and a nested case-control study to calculate the odds ratios of VTE associated with use of different types of OC, after adjustment for potential confounding factors.	OC	VTE	8996419	-1
-We did a cohort analysis to estimate and compare incidence of VTE in users of the main OC preparations, and a nested case-control study to calculate the odds ratios of VTE associated with use of different types of OC, after adjustment for potential confounding factors.	OC	VTE	8996419	-1
-We did a cohort analysis to estimate and compare incidence of VTE in users of the main OC preparations, and a nested case-control study to calculate the odds ratios of VTE associated with use of different types of OC, after adjustment for potential confounding factors.	OC	VTE	8996419	-1
-We did a cohort analysis to estimate and compare incidence of VTE in users of the main OC preparations, and a nested case-control study to calculate the odds ratios of VTE associated with use of different types of OC, after adjustment for potential confounding factors.	OC	VTE	8996419	-1
-CONCLUSIONS: In CYP-induced cystitis, the expression of P2X3 and NK1 receptors increased in urothelium and/or suburothelium.	CYP	cystitis	23666265	1
-Rates of Renal Toxicity in Cancer Patients Receiving Cisplatin With and Without Mannitol.	Mannitol	Cancer	24778426	-1
-Rates of Renal Toxicity in Cancer Patients Receiving Cisplatin With and Without Mannitol.	Mannitol	Renal Toxicity	24778426	-1
-Rates of Renal Toxicity in Cancer Patients Receiving Cisplatin With and Without Mannitol.	Cisplatin	Cancer	24778426	-1
-Rates of Renal Toxicity in Cancer Patients Receiving Cisplatin With and Without Mannitol.	Cisplatin	Renal Toxicity	24778426	-1
-Since mesangial CC clearance from the mesangium did not change during chronic PAN treatment, we conclude that this preferential CC localization within the lesions is caused by an increased CC uptake shortly after injection in apparent vulnerable areas where sclerosis will develop subsequently.	PAN	sclerosis	3990093	-1
-Since mesangial CC clearance from the mesangium did not change during chronic PAN treatment, we conclude that this preferential CC localization within the lesions is caused by an increased CC uptake shortly after injection in apparent vulnerable areas where sclerosis will develop subsequently.	CC	sclerosis	3990093	-1
-Since mesangial CC clearance from the mesangium did not change during chronic PAN treatment, we conclude that this preferential CC localization within the lesions is caused by an increased CC uptake shortly after injection in apparent vulnerable areas where sclerosis will develop subsequently.	CC	sclerosis	3990093	-1
-Since mesangial CC clearance from the mesangium did not change during chronic PAN treatment, we conclude that this preferential CC localization within the lesions is caused by an increased CC uptake shortly after injection in apparent vulnerable areas where sclerosis will develop subsequently.	CC	sclerosis	3990093	-1
-Sixty patients (age-range one month to 14 years) with other types of epilepsy than infantile spasms were treated with clonazepam.	clonazepam	epilepsy	3832950	-1
-Sixty patients (age-range one month to 14 years) with other types of epilepsy than infantile spasms were treated with clonazepam.	clonazepam	spasms	3832950	-1
-These brain substrates may help account for the symptoms of MA abuse, providing therapeutic targets for drug-induced brain injury.	MA	brain injury	15229250	-1
-Two cases of downbeat nystagmus and oscillopsia associated with carbamazepine.	carbamazepine	nystagmus and oscillopsia	3812624	-1
-The effect of clonidine, naphazoline and xylometazoline on analgesia induced by morphine, codeine, fentanyl and pentazocine, and on cataleptic effect of morphine, codine and fentanyl was studied in rats.	morphine	cataleptic	35781	1
-The effect of clonidine, naphazoline and xylometazoline on analgesia induced by morphine, codeine, fentanyl and pentazocine, and on cataleptic effect of morphine, codine and fentanyl was studied in rats.	naphazoline	cataleptic	35781	1
-The effect of clonidine, naphazoline and xylometazoline on analgesia induced by morphine, codeine, fentanyl and pentazocine, and on cataleptic effect of morphine, codine and fentanyl was studied in rats.	pentazocine	cataleptic	35781	-1
-The most distinctive aspect of the barium effect was a demonstrated hypersensitivity of the cardiovascular system to sodium pentobarbital.	sodium pentobarbital	hypersensitivity	3975902	-1
-The most distinctive aspect of the barium effect was a demonstrated hypersensitivity of the cardiovascular system to sodium pentobarbital.	barium	hypersensitivity	3975902	-1
-Pure red cell aplasia, toxic dermatitis and lymphadenopathy in a patient taking diphenylhydantoin.	diphenylhydantoin	Pure red cell aplasia	146391	1
-Pure red cell aplasia, toxic dermatitis and lymphadenopathy in a patient taking diphenylhydantoin.	diphenylhydantoin	toxic dermatitis	146391	-1
-Pure red cell aplasia, toxic dermatitis and lymphadenopathy in a patient taking diphenylhydantoin.	diphenylhydantoin	lymphadenopathy	146391	1
-Recurrent myocardial infarction in a postpartum patient receiving bromocriptine.	bromocriptine	myocardial infarction	1395192	1
-In the present study the role of glial activation and post synaptic toxicity in ICV Streptozotocin (STZ) induced memory impaired rats was explored.	Streptozotocin	synaptic toxicity	24333387	-1
-In the present study the role of glial activation and post synaptic toxicity in ICV Streptozotocin (STZ) induced memory impaired rats was explored.	STZ	memory impaired	24333387	1
-In the present study the role of glial activation and post synaptic toxicity in ICV Streptozotocin (STZ) induced memory impaired rats was explored.	STZ	synaptic toxicity	24333387	-1
-Nelarabine neurotoxicity with concurrent intrathecal chemotherapy: Case report and review of literature.	Nelarabine	neurotoxicity	24664478	-1
-As TNF and PAF are thought to be involved in the development of septic shock and adult respiratory distress syndrome, we hypothesize that high-dose Ara-C may be associated with cytokine release.	Ara	TNF	8318674	-1
-As TNF and PAF are thought to be involved in the development of septic shock and adult respiratory distress syndrome, we hypothesize that high-dose Ara-C may be associated with cytokine release.	Ara	septic shock	8318674	-1
-As TNF and PAF are thought to be involved in the development of septic shock and adult respiratory distress syndrome, we hypothesize that high-dose Ara-C may be associated with cytokine release.	Ara	respiratory distress syndrome	8318674	-1
-Five cases of encephalitis following treatment with diethylcarbamazine (DEC) were observed in Congolese patients with Loa loa filariasis.	diethylcarbamazine	encephalitis	1858969	1
-Five cases of encephalitis following treatment with diethylcarbamazine (DEC) were observed in Congolese patients with Loa loa filariasis.	diethylcarbamazine	Loa loa filariasis	1858969	-1
-Five cases of encephalitis following treatment with diethylcarbamazine (DEC) were observed in Congolese patients with Loa loa filariasis.	DEC	encephalitis	1858969	1
-Five cases of encephalitis following treatment with diethylcarbamazine (DEC) were observed in Congolese patients with Loa loa filariasis.	DEC	Loa loa filariasis	1858969	-1
-A patient taking diphenylhydantoin for 3 weeks developed a generalized skin rash, lymphadenopathy and pure red cell aplasia.	diphenylhydantoin	skin rash	146391	-1
-A patient taking diphenylhydantoin for 3 weeks developed a generalized skin rash, lymphadenopathy and pure red cell aplasia.	diphenylhydantoin	pure red cell aplasia	146391	1
-A patient taking diphenylhydantoin for 3 weeks developed a generalized skin rash, lymphadenopathy and pure red cell aplasia.	diphenylhydantoin	lymphadenopathy	146391	1
-Adverse effects included a mildly dry mouth and a sore throat in 2 patients (2% glycopyrrolate), a light headache in 1 patient (1.5% glycopyrrolate).	glycopyrrolate	dry mouth	12950111	-1
-Adverse effects included a mildly dry mouth and a sore throat in 2 patients (2% glycopyrrolate), a light headache in 1 patient (1.5% glycopyrrolate).	glycopyrrolate	dry mouth	12950111	-1
-Adverse effects included a mildly dry mouth and a sore throat in 2 patients (2% glycopyrrolate), a light headache in 1 patient (1.5% glycopyrrolate).	glycopyrrolate	headache	12950111	1
-The NMS-like encephalopathy that develops in association with the use of antidepressants indicates that NMS and SS are spectrum disorders induced by drugs with both antidopaminergic and serotonergic effects.	antidepressants	encephalopathy	8748050	-1
-The NMS-like encephalopathy that develops in association with the use of antidepressants indicates that NMS and SS are spectrum disorders induced by drugs with both antidopaminergic and serotonergic effects.	antidepressants	disorders	8748050	-1
-The NMS-like encephalopathy that develops in association with the use of antidepressants indicates that NMS and SS are spectrum disorders induced by drugs with both antidopaminergic and serotonergic effects.	antidepressants	NMS	8748050	-1
-The NMS-like encephalopathy that develops in association with the use of antidepressants indicates that NMS and SS are spectrum disorders induced by drugs with both antidopaminergic and serotonergic effects.	antidepressants	NMS	8748050	-1
-The NMS-like encephalopathy that develops in association with the use of antidepressants indicates that NMS and SS are spectrum disorders induced by drugs with both antidopaminergic and serotonergic effects.	antidepressants	SS	8748050	-1
-Bpd was administered to 459 patients (361 males, 63+/-12 years old) comprising 378 AF and 81 AFL cases.	Bpd	AFL	16723784	-1
-Bpd was administered to 459 patients (361 males, 63+/-12 years old) comprising 378 AF and 81 AFL cases.	Bpd	AF	16723784	-1
-A score of 7 on the Naranjo adverse drug reaction probability scale indicates a probable relationship between the patient's sinus bradycardia and the drug interaction between metoprolol and terbinafine.	terbinafine	sinus bradycardia	24894748	-1
-A score of 7 on the Naranjo adverse drug reaction probability scale indicates a probable relationship between the patient's sinus bradycardia and the drug interaction between metoprolol and terbinafine.	metoprolol	sinus bradycardia	24894748	-1
-Late-onset scleroderma renal crisis induced by tacrolimus and prednisolone: a case report.	tacrolimus	scleroderma renal crisis	22836123	-1
-Late-onset scleroderma renal crisis induced by tacrolimus and prednisolone: a case report.	prednisolone	scleroderma renal crisis	22836123	-1
-Encephalopathy has been reported in 10-40% of patients receiving high-dose IV ifosfamide.	ifosfamide	Encephalopathy	24209900	-1
-Pulmonary infections were less common in cyclosporine-treated renal patients than in Aza-treated patients (P less than 0.05).	cyclosporine	Pulmonary infections	6310832	-1
-Pulmonary infections were less common in cyclosporine-treated renal patients than in Aza-treated patients (P less than 0.05).	Aza	Pulmonary infections	6310832	-1
-It was found that three drugs stimulating central NA receptors failed to affect the analgesic ED50 of all antinociceptive agents and they enhanced catalepsy induced by morphine and fentanyl.	morphine	catalepsy	35781	1
-It was found that three drugs stimulating central NA receptors failed to affect the analgesic ED50 of all antinociceptive agents and they enhanced catalepsy induced by morphine and fentanyl.	fentanyl	catalepsy	35781	1
-It was found that three drugs stimulating central NA receptors failed to affect the analgesic ED50 of all antinociceptive agents and they enhanced catalepsy induced by morphine and fentanyl.	NA	catalepsy	35781	-1
-METHODS: Retrospective chart review including clinical data and EEG recordings was done on five patients, admitted to MD Anderson Cancer Center between years 2009 and 2012, who developed ifosfamide related acute encephalopathy.	ifosfamide	encephalopathy	24209900	-1
-METHODS: Retrospective chart review including clinical data and EEG recordings was done on five patients, admitted to MD Anderson Cancer Center between years 2009 and 2012, who developed ifosfamide related acute encephalopathy.	ifosfamide	MD Anderson Cancer	24209900	-1
-OBJECTIVE: We describe the unique CT features of ureteric calculi in six HIV-infected patients receiving indinavir, the most commonly used HIV protease inhibitor, which is associated with an increased incidence of urolithiasis.	indinavir	HIV-infected	9725303	-1
-OBJECTIVE: We describe the unique CT features of ureteric calculi in six HIV-infected patients receiving indinavir, the most commonly used HIV protease inhibitor, which is associated with an increased incidence of urolithiasis.	indinavir	urolithiasis	9725303	-1
-Evidence for a cholinergic role in haloperidol-induced catalepsy.	haloperidol	catalepsy	3925479	1
-The lack of any consistent protective effect noted with the alkylxanthines tested in the present study indicates that adenosine plays little, if any, pathophysiological role in gentamicin-induced ARF.	gentamicin	ARF	2907577	1
-The lack of any consistent protective effect noted with the alkylxanthines tested in the present study indicates that adenosine plays little, if any, pathophysiological role in gentamicin-induced ARF.	adenosine	ARF	2907577	-1
-Safety and efficacy of fluocinolone acetonide intravitreal implant (0.59 mg) in birdshot retinochoroidopathy.	fluocinolone acetonide	birdshot retinochoroidopathy	24999722	-1
-The aim of this study is to investigate the effects of propofol in intralipid or medialipid emulsions on bupivacaine-induced cardiotoxicity.	propofol	cardiotoxicity	24438483	-1
-The aim of this study is to investigate the effects of propofol in intralipid or medialipid emulsions on bupivacaine-induced cardiotoxicity.	bupivacaine	cardiotoxicity	24438483	1
-Cyclical low-dose oestrogen therapy with 7--13 days of progestagen does not seem to increase the risk of endometrial hyperplasia or carcinoma.	progestagen	carcinoma	89511	-1
-Cyclical low-dose oestrogen therapy with 7--13 days of progestagen does not seem to increase the risk of endometrial hyperplasia or carcinoma.	progestagen	endometrial hyperplasia	89511	-1
-Cyclical low-dose oestrogen therapy with 7--13 days of progestagen does not seem to increase the risk of endometrial hyperplasia or carcinoma.	oestrogen	carcinoma	89511	-1
-Cyclical low-dose oestrogen therapy with 7--13 days of progestagen does not seem to increase the risk of endometrial hyperplasia or carcinoma.	oestrogen	endometrial hyperplasia	89511	-1
-We suggest a timely EEG evaluation for patients receiving ifosfamide who develop features of encephalopathy.	ifosfamide	encephalopathy	24209900	-1
-Skin rash is a well-known complication of diphenylhydantoin treatment as is benign and malignant lymphadenopathy.	diphenylhydantoin	Skin rash	146391	-1
-Toleration of high doses of angiotensin-converting enzyme inhibitors in patients with chronic heart failure: results from the ATLAS trial.	angiotensin	chronic heart failure	11176729	-1
-Nefiracetam (DM-9384) reverses apomorphine-induced amnesia of a passive avoidance response: delayed emergence of the memory retention effects.	Nefiracetam	amnesia	8829135	-1
-Nefiracetam (DM-9384) reverses apomorphine-induced amnesia of a passive avoidance response: delayed emergence of the memory retention effects.	DM-9384	amnesia	8829135	-1
-Nefiracetam (DM-9384) reverses apomorphine-induced amnesia of a passive avoidance response: delayed emergence of the memory retention effects.	apomorphine	amnesia	8829135	1
-Of the cyclosporine patients, 15% had symptoms related to CMV infection.	cyclosporine	CMV infection	6310832	-1
-Bromocriptine has been implicated in several previous case reports of myocardial infarction in the puerperium.	Bromocriptine	myocardial infarction	1395192	1
-OBJECTIVE: To report two cases of a possible adverse interaction between clonidine and verapamil resulting in atrioventricular (AV) block in both patients and severe hypotension in one patient.	verapamil	atrioventricular (AV) block	7949506	1
-OBJECTIVE: To report two cases of a possible adverse interaction between clonidine and verapamil resulting in atrioventricular (AV) block in both patients and severe hypotension in one patient.	clonidine	hypotension	7949506	1
-Phenytoin encephalopathy as probable idiosyncratic reaction: case report.	Phenytoin	encephalopathy	891494	1
-EDRF (endothelium-derived relaxing factor)/nitric oxide does not seem to play an important role in the peptide-produced hypotension.	factor)/nitric oxide	hypotension	9881641	-1
-In fact the concentration of free DPH was normal, the patient presented a retarded morbilliform rash during DPH treatment, the protidogram was normal, and an intradermic DPH injection had no local effect.	DPH	rash	891494	-1
-In fact the concentration of free DPH was normal, the patient presented a retarded morbilliform rash during DPH treatment, the protidogram was normal, and an intradermic DPH injection had no local effect.	DPH	rash	891494	-1
-In fact the concentration of free DPH was normal, the patient presented a retarded morbilliform rash during DPH treatment, the protidogram was normal, and an intradermic DPH injection had no local effect.	DPH	rash	891494	-1
-We studied the effect of lindane (150 mg/kg) on the GABAergic and dopaminergic systems by measuring the concentration of GABA, dopamine and its metabolites in 7 brain areas at the onset of seizures.	lindane	seizures	2453942	1
-We studied the effect of lindane (150 mg/kg) on the GABAergic and dopaminergic systems by measuring the concentration of GABA, dopamine and its metabolites in 7 brain areas at the onset of seizures.	GABA	seizures	2453942	-1
-We studied the effect of lindane (150 mg/kg) on the GABAergic and dopaminergic systems by measuring the concentration of GABA, dopamine and its metabolites in 7 brain areas at the onset of seizures.	dopamine	seizures	2453942	-1
-BACKGROUND: Treatment with angiotensin-converting enzyme (ACE) inhibitors reduces mortality and morbidity in patients with chronic heart failure (CHF), but most affected patients are not receiving these agents or are being treated with doses lower than those found to be efficacious in trials, primarily because of concerns about the safety and tolerability of these agents, especially at the recommended doses.	angiotensin	chronic heart failure	11176729	-1
-BACKGROUND: Treatment with angiotensin-converting enzyme (ACE) inhibitors reduces mortality and morbidity in patients with chronic heart failure (CHF), but most affected patients are not receiving these agents or are being treated with doses lower than those found to be efficacious in trials, primarily because of concerns about the safety and tolerability of these agents, especially at the recommended doses.	angiotensin	CHF	11176729	-1
-Patients who were using a higher dose of levodopa had a greater OPSE and a trend toward a smaller oral transit time (Pearson's correlation, P = 0.01 and 0.08, respectively).	levodopa	OPSE	15625689	-1
-Mesna significantly reduces IFO's genotoxicity, while when administered in high concentrations it acts in an inhibitory fashion on the cytostatic action of the drug.	Mesna	genotoxicity	23949582	-1
-Mesna significantly reduces IFO's genotoxicity, while when administered in high concentrations it acts in an inhibitory fashion on the cytostatic action of the drug.	IFO's	genotoxicity	23949582	-1
-High PELD and Child-Pugh scores before LT and high post-operative serum Tbil may be contributory risk factors for TAC-related seizures.	TAC	seizures	24283660	1
-In vivo evidences suggesting the role of oxidative stress in pathogenesis of vancomycin-induced nephrotoxicity: protection by erdosteine.	vancomycin	nephrotoxicity	16112787	1
-In vivo evidences suggesting the role of oxidative stress in pathogenesis of vancomycin-induced nephrotoxicity: protection by erdosteine.	erdosteine	nephrotoxicity	16112787	-1
-The aims of this study were to examine vancomycin (VCM)-induced oxidative stress that promotes production of reactive oxygen species (ROS) and to investigate the role of erdosteine, an expectorant agent, which has also antioxidant properties, on kidney tissue against the possible VCM-induced renal impairment in rats.	oxygen	renal impairment	16112787	-1
-The aims of this study were to examine vancomycin (VCM)-induced oxidative stress that promotes production of reactive oxygen species (ROS) and to investigate the role of erdosteine, an expectorant agent, which has also antioxidant properties, on kidney tissue against the possible VCM-induced renal impairment in rats.	erdosteine	renal impairment	16112787	-1
-The authors examined the anticonvulsant effects of MK-801 on the pilocarpine-induced seizure model.	MK-801	seizure	9061777	1
-The authors examined the anticonvulsant effects of MK-801 on the pilocarpine-induced seizure model.	pilocarpine	seizure	9061777	1
-This study demonstrates that hydroxytyrosol protect rat heart damage provoked by doxorubicin decreasing oxidative damage and mitochondrial alterations.	doxorubicin	heart damage	24727461	1
-This study demonstrates that hydroxytyrosol protect rat heart damage provoked by doxorubicin decreasing oxidative damage and mitochondrial alterations.	hydroxytyrosol	heart damage	24727461	-1
-Flumazenil induces seizures and death in mixed cocaine-diazepam intoxications.	cocaine-diazepam	seizures	8135424	1
-Flumazenil induces seizures and death in mixed cocaine-diazepam intoxications.	cocaine-diazepam	death	8135424	-1
-Flumazenil induces seizures and death in mixed cocaine-diazepam intoxications.	Flumazenil	seizures	8135424	1
-Flumazenil induces seizures and death in mixed cocaine-diazepam intoxications.	Flumazenil	death	8135424	-1
-Rats were divided into three groups: sham, VCM and VCM plus erdosteine.	VCM	plus	16112787	-1
-Rats were divided into three groups: sham, VCM and VCM plus erdosteine.	VCM	plus	16112787	-1
-Rats were divided into three groups: sham, VCM and VCM plus erdosteine.	erdosteine	plus	16112787	-1
-In the present study, the effects of manipulating the activity of the gamma-aminobutyric acid (GABA)-mediated synaptic inhibition within the substantia nigra on seizures produced by pilocarpine in rats, were investigated.	gamma-aminobutyric acid	seizures	3708328	-1
-In the present study, the effects of manipulating the activity of the gamma-aminobutyric acid (GABA)-mediated synaptic inhibition within the substantia nigra on seizures produced by pilocarpine in rats, were investigated.	GABA)-mediated	seizures	3708328	-1
-In the present study, the effects of manipulating the activity of the gamma-aminobutyric acid (GABA)-mediated synaptic inhibition within the substantia nigra on seizures produced by pilocarpine in rats, were investigated.	pilocarpine	seizures	3708328	1
-MK-801, a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, was tested for anticonvulsant effects in rats using two seizure models, coadministration of lithium and pilocarpine and administration of a high dose of pilocarpine alone.	MK-801	seizure	2553470	-1
-MK-801, a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, was tested for anticonvulsant effects in rats using two seizure models, coadministration of lithium and pilocarpine and administration of a high dose of pilocarpine alone.	lithium	seizure	2553470	-1
-MK-801, a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, was tested for anticonvulsant effects in rats using two seizure models, coadministration of lithium and pilocarpine and administration of a high dose of pilocarpine alone.	pilocarpine	seizure	2553470	-1
-MK-801, a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, was tested for anticonvulsant effects in rats using two seizure models, coadministration of lithium and pilocarpine and administration of a high dose of pilocarpine alone.	pilocarpine	seizure	2553470	-1
-Indomethacin, 1-10 mg/kg, and ibuprofen, 10-100 mg/kg, failed to modulate seizures produced by pilocarpine.	Indomethacin	seizures	3191389	-1
-Indomethacin, 1-10 mg/kg, and ibuprofen, 10-100 mg/kg, failed to modulate seizures produced by pilocarpine.	pilocarpine	seizures	3191389	1
-Indomethacin, 1-10 mg/kg, and ibuprofen, 10-100 mg/kg, failed to modulate seizures produced by pilocarpine.	ibuprofen	seizures	3191389	-1
-Levodopa-induced ocular dyskinesias in Parkinson's disease.	Levodopa	Parkinson's disease	11835460	-1
-Levodopa-induced ocular dyskinesias in Parkinson's disease.	Levodopa	ocular dyskinesias	11835460	-1
-VCM administration to control rats significantly increased renal malondialdehyde (MDA) and urinary N-acetyl-beta-d-glucosaminidase (NAG, a marker of renal tubular injury) excretion but decreased superoxide dismutase (SOD) and catalase (CAT) activities.	VCM	renal tubular injury	16112787	-1
-VCM administration to control rats significantly increased renal malondialdehyde (MDA) and urinary N-acetyl-beta-d-glucosaminidase (NAG, a marker of renal tubular injury) excretion but decreased superoxide dismutase (SOD) and catalase (CAT) activities.	superoxide	renal tubular injury	16112787	-1
-VCM administration to control rats significantly increased renal malondialdehyde (MDA) and urinary N-acetyl-beta-d-glucosaminidase (NAG, a marker of renal tubular injury) excretion but decreased superoxide dismutase (SOD) and catalase (CAT) activities.	malondialdehyde	renal tubular injury	16112787	-1
-VCM administration to control rats significantly increased renal malondialdehyde (MDA) and urinary N-acetyl-beta-d-glucosaminidase (NAG, a marker of renal tubular injury) excretion but decreased superoxide dismutase (SOD) and catalase (CAT) activities.	MDA	renal tubular injury	16112787	-1
-Intraoperative bradycardia and hypotension associated with timolol and pilocarpine eye drops.	timolol	Intraoperative bradycardia	6615679	-1
-Intraoperative bradycardia and hypotension associated with timolol and pilocarpine eye drops.	timolol	hypotension	6615679	1
-Intraoperative bradycardia and hypotension associated with timolol and pilocarpine eye drops.	pilocarpine	Intraoperative bradycardia	6615679	-1
-Intraoperative bradycardia and hypotension associated with timolol and pilocarpine eye drops.	pilocarpine	hypotension	6615679	1
-CIN was defined as an increase in serum creatinine (Cr) of 0.5 mg/dl or more, or elevation of Cr to 25 % over baseline.	creatinine	CIN	24220752	-1
-CIN was defined as an increase in serum creatinine (Cr) of 0.5 mg/dl or more, or elevation of Cr to 25 % over baseline.	Cr	CIN	24220752	-1
-CIN was defined as an increase in serum creatinine (Cr) of 0.5 mg/dl or more, or elevation of Cr to 25 % over baseline.	Cr	CIN	24220752	-1
-Erdosteine showed histopathological protection against VCM-induced nephrotoxicity.	Erdosteine	nephrotoxicity	16112787	-1
-Valproate-induced hyperammonemic encephalopathy in a renal transplanted patient.	Valproate	hyperammonemic encephalopathy	24665854	-1
-We recorded the eye movements of two patients with reversible downbeat nystagmus related to carbamazepine therapy.	carbamazepine	nystagmus	3812624	-1
-Animals became somnolent after diazepam and then active after flumazenil administration.	diazepam	somnolent	8135424	-1
-Animals became somnolent after diazepam and then active after flumazenil administration.	flumazenil	somnolent	8135424	-1
-The nystagmus of both patients resolved after reduction of the serum carbamazepine levels.	carbamazepine	nystagmus	3812624	-1
-In this patient the time relation between the ingestion of diphenylhydantoin and the occurrence of the skin rash, lymphadenopathy and pure red cell aplasia is very suggestive of a direct connection.	diphenylhydantoin	skin rash	146391	-1
-In this patient the time relation between the ingestion of diphenylhydantoin and the occurrence of the skin rash, lymphadenopathy and pure red cell aplasia is very suggestive of a direct connection.	diphenylhydantoin	pure red cell aplasia	146391	1
-In this patient the time relation between the ingestion of diphenylhydantoin and the occurrence of the skin rash, lymphadenopathy and pure red cell aplasia is very suggestive of a direct connection.	diphenylhydantoin	lymphadenopathy	146391	1
-The left ventricular dysfunction was significantly lower in the groups treated with 25 and 50mg/kg of metformin.	metformin	ventricular dysfunction	24842192	-1
-Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin.	telaprevir	hepatitis C virus infected	24927617	-1
-Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin.	telaprevir	Rhabdomyolysis	24927617	1
-Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin.	simvastatin	hepatitis C virus infected	24927617	-1
-Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin.	simvastatin	Rhabdomyolysis	24927617	1
-Flurothyl seizure testing proved to be a rapid and reliable technique with which to evaluate seizure susceptibility.	Flurothyl	seizure	3685052	-1
-Flurothyl seizure testing proved to be a rapid and reliable technique with which to evaluate seizure susceptibility.	Flurothyl	seizure	3685052	-1
-The results suggest that increased brain serotoninergic transmission with fluoxetine may reduce levodopa- or dopamine agonist-induced dyskinesias without aggravating parkinsonian motor disability.	fluoxetine	parkinsonian	7477981	-1
-The results suggest that increased brain serotoninergic transmission with fluoxetine may reduce levodopa- or dopamine agonist-induced dyskinesias without aggravating parkinsonian motor disability.	fluoxetine	dyskinesias	7477981	1
-The results suggest that increased brain serotoninergic transmission with fluoxetine may reduce levodopa- or dopamine agonist-induced dyskinesias without aggravating parkinsonian motor disability.	dopamine	parkinsonian	7477981	-1
-The results suggest that increased brain serotoninergic transmission with fluoxetine may reduce levodopa- or dopamine agonist-induced dyskinesias without aggravating parkinsonian motor disability.	dopamine	dyskinesias	7477981	-1
-The results suggest that increased brain serotoninergic transmission with fluoxetine may reduce levodopa- or dopamine agonist-induced dyskinesias without aggravating parkinsonian motor disability.	levodopa-	parkinsonian	7477981	-1
-The results suggest that increased brain serotoninergic transmission with fluoxetine may reduce levodopa- or dopamine agonist-induced dyskinesias without aggravating parkinsonian motor disability.	levodopa-	dyskinesias	7477981	-1
-An integrated characterization of serological, pathological, and functional events in doxorubicin-induced cardiotoxicity.	doxorubicin	cardiotoxicity	24675088	-1
-A higher cumulative incidence of persistent leukocyturia was found in children with an area under the curve >19 mg/L x h or a peak serum level of indinavir >12 mg/L. In 4 children, indinavir was discontinued because of nephrotoxicity.	indinavir	nephrotoxicity	12165618	1
-Patients with essential hypertension (mean sitting diastolic BP [MSDBP], > or =95 mm Hg and <110 mm Hg) were randomized to 1 of 8 treatment groups: VAL 160 or 320 mg; HCTZ 12.5 or 25 mg; VAL/HCTZ 160/12.5, 320/12.5, or 320/25 mg; or placebo.	HCTZ	hypertension	17379047	-1
-Patients with essential hypertension (mean sitting diastolic BP [MSDBP], > or =95 mm Hg and <110 mm Hg) were randomized to 1 of 8 treatment groups: VAL 160 or 320 mg; HCTZ 12.5 or 25 mg; VAL/HCTZ 160/12.5, 320/12.5, or 320/25 mg; or placebo.	HCTZ	hypertension	17379047	-1
-Patients with essential hypertension (mean sitting diastolic BP [MSDBP], > or =95 mm Hg and <110 mm Hg) were randomized to 1 of 8 treatment groups: VAL 160 or 320 mg; HCTZ 12.5 or 25 mg; VAL/HCTZ 160/12.5, 320/12.5, or 320/25 mg; or placebo.	VAL	hypertension	17379047	-1
-Patients with essential hypertension (mean sitting diastolic BP [MSDBP], > or =95 mm Hg and <110 mm Hg) were randomized to 1 of 8 treatment groups: VAL 160 or 320 mg; HCTZ 12.5 or 25 mg; VAL/HCTZ 160/12.5, 320/12.5, or 320/25 mg; or placebo.	VAL	hypertension	17379047	-1
-This occlusion occurred after EACA therapy in a patient with SAH and histopathological documentation of recurrent SAH.	EACA	SAH	448423	1
-This occlusion occurred after EACA therapy in a patient with SAH and histopathological documentation of recurrent SAH.	EACA	SAH	448423	1
-Our case suggests that troponin elevation could be associated with statin induced rhabdomyolysis, which may warrant further studies.	statin	rhabdomyolysis	25041770	1
-An earlier suggestion of increased lung cancer risk at high levels of metolachlor use in this cohort was not confirmed in this update.	metolachlor	lung cancer	26033014	-1
-RAD001, an oral inhibitor of the mammalian target of rapamycin (mTOR), has shown phase I efficacy in NSCLC.	rapamycin	NSCLC	19549709	-1
-RAD001, an oral inhibitor of the mammalian target of rapamycin (mTOR), has shown phase I efficacy in NSCLC.	RAD001	NSCLC	19549709	-1
-Metformin protects against seizures, learning and memory impairments and oxidative damage induced by pentylenetetrazole-induced kindling in mice.	Metformin	seizures	24802403	-1
-Metformin protects against seizures, learning and memory impairments and oxidative damage induced by pentylenetetrazole-induced kindling in mice.	Metformin	learning and memory impairments	24802403	-1
-Trimethoprim-induced immune hemolytic anemia in a pediatric oncology patient presenting as an acute hemolytic transfusion reaction.	Trimethoprim	hemolytic transfusion reaction	20589632	-1
-Trimethoprim-induced immune hemolytic anemia in a pediatric oncology patient presenting as an acute hemolytic transfusion reaction.	Trimethoprim	hemolytic anemia	20589632	1
-Bort-dex was an effective salvage treatment for MM patients, particularly for those in first relapse.	dex	MM	23864035	-1
-A total of 66 children from 16 Pediatric Oncology Group institutions with "standard-risk" acute lymphoblastic leukemia, 1.00 to 9.99 years at diagnosis, without evidence of CNS leukemia at diagnosis were enrolled on ACCL0131: 28 from P9201 and 38 from P9605.	P9605	acute lymphoblastic leukemia	24345882	-1
-A total of 66 children from 16 Pediatric Oncology Group institutions with "standard-risk" acute lymphoblastic leukemia, 1.00 to 9.99 years at diagnosis, without evidence of CNS leukemia at diagnosis were enrolled on ACCL0131: 28 from P9201 and 38 from P9605.	P9605	leukemia	24345882	-1
-Acute neurologic dysfunction after high-dose etoposide therapy for malignant glioma.	etoposide	malignant glioma	3289726	-1
-Acute neurologic dysfunction after high-dose etoposide therapy for malignant glioma.	etoposide	neurologic dysfunction	3289726	-1
-Severe polyneuropathy and motor loss after intrathecal thiotepa combination chemotherapy: description of two cases.	thiotepa	polyneuropathy	2131034	1
-Two cases of severe delayed neurologic toxicity related to the administration of intrathecal (IT) combination chemotherapy including thiotepa (TSPA) are presented.	thiotepa	neurologic toxicity	2131034	-1
-We describe a case of progressive loss of vision associated with linezolid therapy.	linezolid	loss of vision	24088636	-1
-In spite of the fact that TSPA is a useful IT agent, its combination with MTX, ara-C and radiotherapy could cause severe neurotoxicity.	MTX	neurotoxicity	2131034	-1
-In spite of the fact that TSPA is a useful IT agent, its combination with MTX, ara-C and radiotherapy could cause severe neurotoxicity.	ara	neurotoxicity	2131034	-1
-Although moderate anticonvulsant effects of S-312-d in higher doses were observed against the clonic convulsions induced by pentylenetetrazole (85 mg/kg, s.c.) or bemegride (40 mg/kg, s.c.), no effects were observed in convulsions induced by N-methyl-D-aspartate, picrotoxin, or electroshock in Slc:ddY mice.	S-312-d	convulsions	7967231	-1
-Although moderate anticonvulsant effects of S-312-d in higher doses were observed against the clonic convulsions induced by pentylenetetrazole (85 mg/kg, s.c.) or bemegride (40 mg/kg, s.c.), no effects were observed in convulsions induced by N-methyl-D-aspartate, picrotoxin, or electroshock in Slc:ddY mice.	S-312-d	convulsions	7967231	-1
-Although moderate anticonvulsant effects of S-312-d in higher doses were observed against the clonic convulsions induced by pentylenetetrazole (85 mg/kg, s.c.) or bemegride (40 mg/kg, s.c.), no effects were observed in convulsions induced by N-methyl-D-aspartate, picrotoxin, or electroshock in Slc:ddY mice.	picrotoxin	convulsions	7967231	1
-Although moderate anticonvulsant effects of S-312-d in higher doses were observed against the clonic convulsions induced by pentylenetetrazole (85 mg/kg, s.c.) or bemegride (40 mg/kg, s.c.), no effects were observed in convulsions induced by N-methyl-D-aspartate, picrotoxin, or electroshock in Slc:ddY mice.	bemegride	convulsions	7967231	1
-To the best of our knowledge, the occurrence of neuroleptic malignant syndrome due to combination therapy with tetrabenazine and tiapride has not been previously reported.	tiapride	neuroleptic malignant syndrome	24881749	1
-UNASSIGNED: Epidemiological studies of 1,3-butadiene have suggest that exposures to humans are associated with chronic myeloid leukemia (CML).	1,3-butadiene	chronic myeloid leukemia	26002693	-1
-UNASSIGNED: Epidemiological studies of 1,3-butadiene have suggest that exposures to humans are associated with chronic myeloid leukemia (CML).	1,3-butadiene	CML	26002693	-1
-Severe nelarabine neurotoxicity in a patient who received concurrent intrathecal (IT) chemotherapy is reported.	nelarabine	neurotoxicity	24664478	-1
-Improvement by denopamine (TA-064) of pentobarbital-induced cardiac failure in the dog heart-lung preparation.	denopamine	cardiac failure	3831029	-1
-Improvement by denopamine (TA-064) of pentobarbital-induced cardiac failure in the dog heart-lung preparation.	TA-064	cardiac failure	3831029	-1
-Improvement by denopamine (TA-064) of pentobarbital-induced cardiac failure in the dog heart-lung preparation.	pentobarbital	cardiac failure	3831029	1
-The efficacy of denopamine, an orally active beta 1-adrenoceptor agonist, in improving cardiac failure was assessed in dog heart-lung preparations.	denopamine	cardiac failure	3831029	-1
-Longitudinal association of alcohol use with HIV disease progression and psychological health of women with HIV.	alcohol	HIV disease	20024739	-1
-Longitudinal association of alcohol use with HIV disease progression and psychological health of women with HIV.	alcohol	HIV	20024739	-1
-Reported herein is an autopsy case of valvular heart disease, in a patient who developed a lung mass (1.5 cm in diameter) and proteinuria (2.76 g/day) after treatment with amiodarone for a long time.	amiodarone	proteinuria	18801087	-1
-Reported herein is an autopsy case of valvular heart disease, in a patient who developed a lung mass (1.5 cm in diameter) and proteinuria (2.76 g/day) after treatment with amiodarone for a long time.	amiodarone	valvular heart disease	18801087	-1
-In animals pretreated with microinjections of isoniazid, 150 micrograms, an inhibitor of activity of the GABA-synthesizing enzyme, L-glutamic acid decarboxylase, into the substantia nigra pars reticulata (SNR), bilaterally, non-convulsant doses of pilocarpine, 100 and 200 mg/kg, resulted in severe motor limbic seizures and status epilepticus.	isoniazid	status epilepticus	3708328	-1
-In animals pretreated with microinjections of isoniazid, 150 micrograms, an inhibitor of activity of the GABA-synthesizing enzyme, L-glutamic acid decarboxylase, into the substantia nigra pars reticulata (SNR), bilaterally, non-convulsant doses of pilocarpine, 100 and 200 mg/kg, resulted in severe motor limbic seizures and status epilepticus.	isoniazid	seizures	3708328	-1
-In animals pretreated with microinjections of isoniazid, 150 micrograms, an inhibitor of activity of the GABA-synthesizing enzyme, L-glutamic acid decarboxylase, into the substantia nigra pars reticulata (SNR), bilaterally, non-convulsant doses of pilocarpine, 100 and 200 mg/kg, resulted in severe motor limbic seizures and status epilepticus.	GABA	status epilepticus	3708328	-1
-In animals pretreated with microinjections of isoniazid, 150 micrograms, an inhibitor of activity of the GABA-synthesizing enzyme, L-glutamic acid decarboxylase, into the substantia nigra pars reticulata (SNR), bilaterally, non-convulsant doses of pilocarpine, 100 and 200 mg/kg, resulted in severe motor limbic seizures and status epilepticus.	GABA	seizures	3708328	-1
-In animals pretreated with microinjections of isoniazid, 150 micrograms, an inhibitor of activity of the GABA-synthesizing enzyme, L-glutamic acid decarboxylase, into the substantia nigra pars reticulata (SNR), bilaterally, non-convulsant doses of pilocarpine, 100 and 200 mg/kg, resulted in severe motor limbic seizures and status epilepticus.	pilocarpine	status epilepticus	3708328	-1
-In animals pretreated with microinjections of isoniazid, 150 micrograms, an inhibitor of activity of the GABA-synthesizing enzyme, L-glutamic acid decarboxylase, into the substantia nigra pars reticulata (SNR), bilaterally, non-convulsant doses of pilocarpine, 100 and 200 mg/kg, resulted in severe motor limbic seizures and status epilepticus.	pilocarpine	seizures	3708328	1
-UNASSIGNED: Metolachlor, a widely used herbicide, is classified as a Group C carcinogen by the U.S. Environmental Protection Agency based on increased liver neoplasms in female rats.	herbicide	liver neoplasms	26033014	-1
-During hypotension produced by SNP similar decreases were observed in mean pulmonary arterial pressure (p less than 0.01), central venous pressure (p less than 0.001), left ventricular end-diastolic pressure (p less than 0.01), total peripheral resistance (p less than 0.001), rate pressure product (p less than 0.001), and oxygen content difference between arterial and mixed venous blood (p less than 0.05), while heart rate (p less than 0.001) and cardiac output (p less than 0.05) were increased. Recoveries of heart rate and left ventricular end-diastolic pressure were not shown within 60 min after SNP had been stopped.	oxygen	hypotension	7147232	-1
-Mefenamic acid, 26 (22-30) mg/kg, prevented seizures and protected rats from seizure-related brain damage induced by pilocarpine, 380 mg/kg.	Mefenamic acid	seizures	3191389	-1
-Mefenamic acid, 26 (22-30) mg/kg, prevented seizures and protected rats from seizure-related brain damage induced by pilocarpine, 380 mg/kg.	Mefenamic acid	seizure	3191389	-1
-Mefenamic acid, 26 (22-30) mg/kg, prevented seizures and protected rats from seizure-related brain damage induced by pilocarpine, 380 mg/kg.	Mefenamic acid	brain damage	3191389	-1
-Mefenamic acid, 26 (22-30) mg/kg, prevented seizures and protected rats from seizure-related brain damage induced by pilocarpine, 380 mg/kg.	pilocarpine	seizures	3191389	1
-Mefenamic acid, 26 (22-30) mg/kg, prevented seizures and protected rats from seizure-related brain damage induced by pilocarpine, 380 mg/kg.	pilocarpine	seizure	3191389	1
-Mefenamic acid, 26 (22-30) mg/kg, prevented seizures and protected rats from seizure-related brain damage induced by pilocarpine, 380 mg/kg.	pilocarpine	brain damage	3191389	-1
-Torsades de pointes occurred early during treatment even with low doses of oral d,l-sotalol.	sotalol	Torsades de pointes	9125676	1
-In 2002, the U.S. Preventive Services Task Force (USPSTF) strongly recommended that clinicians discuss aspirin with adults who are at increased risk for coronary heart disease.	aspirin	coronary heart disease	19293073	-1
-Butyrylcholinesterase deficiency is characterized by prolonged apnea after the use of muscle relaxants (suxamethonium or mivacurium) in patients who have mutations in the BCHE gene.	suxamethonium	apnea	25054547	1
-The hemodynamic and antiadrenergic effects of dronedarone, a noniodinated compound structurally related to amiodarone, were compared with those of amiodarone after prolonged oral administration, both at rest and during sympathetic stimulation in conscious dogs with a healed myocardial infarction.	amiodarone	myocardial infarction	10975596	-1
-The hemodynamic and antiadrenergic effects of dronedarone, a noniodinated compound structurally related to amiodarone, were compared with those of amiodarone after prolonged oral administration, both at rest and during sympathetic stimulation in conscious dogs with a healed myocardial infarction.	amiodarone	myocardial infarction	10975596	-1
-The hemodynamic and antiadrenergic effects of dronedarone, a noniodinated compound structurally related to amiodarone, were compared with those of amiodarone after prolonged oral administration, both at rest and during sympathetic stimulation in conscious dogs with a healed myocardial infarction.	dronedarone	myocardial infarction	10975596	-1
-No arrhythmias were induced by these doses of denopamine.	denopamine	arrhythmias	3831029	-1
-These data indicate that adult mouse atrial and ventricular cardiomyocytes do not synthesize DNA in response to isoproterenol-induced cardiac hypertrophy.	isoproterenol	cardiac hypertrophy	8184922	1
-STZ causes increased expression of GFAP, CD11b and TNF-a indicating glial activation and neuroinflammation.	STZ	TNF	24333387	-1
-Myopathy due to lack of vitamin E and myopathy induced by certain viruses have much in common anatomically and pathologically with the human form.	vitamin E	Myopathy	753803	-1
-Myopathy due to lack of vitamin E and myopathy induced by certain viruses have much in common anatomically and pathologically with the human form.	vitamin E	myopathy	753803	-1
-OBJECTIVE: To report a case of syndrome of inappropriate anti-diuretic hormone (SIADH) secretion associated with desvenlafaxine.	desvenlafaxine	SIADH	24234943	-1
-The lung mass was highly suspected to be lung cancer on CT and positron emission tomography, but histologically the lesion was composed of lymphoplasmacytic infiltrates in alveolar walls and intra-alveolar accumulation of foamy macrophages containing characteristic myelinoid bodies, indicating that it was an amiodarone-related lesion.	amiodarone	lung cancer	18801087	-1
-In this report, we describe a patient with acute hyperkinetic delirium connected with a high serum total fluoxetine (fluoxetine plus desmethylfluoxetine) concentration.	desmethylfluoxetine	hyperkinetic delirium	8312983	-1
-In this report, we describe a patient with acute hyperkinetic delirium connected with a high serum total fluoxetine (fluoxetine plus desmethylfluoxetine) concentration.	fluoxetine	hyperkinetic delirium	8312983	1
-METHODS: Stage IIIb or IV NSCLC patients, with two or fewer prior chemotherapy regimens, one platinum based (stratum 1) or both chemotherapy and epidermal growth factor receptor tyrosine kinase inhibitors (stratum 2), received RAD001 10 mg/day until progression or unacceptable toxicity.	RAD001	toxicity	19549709	-1
-METHODS: Stage IIIb or IV NSCLC patients, with two or fewer prior chemotherapy regimens, one platinum based (stratum 1) or both chemotherapy and epidermal growth factor receptor tyrosine kinase inhibitors (stratum 2), received RAD001 10 mg/day until progression or unacceptable toxicity.	RAD001	NSCLC	19549709	-1
-METHODS: Stage IIIb or IV NSCLC patients, with two or fewer prior chemotherapy regimens, one platinum based (stratum 1) or both chemotherapy and epidermal growth factor receptor tyrosine kinase inhibitors (stratum 2), received RAD001 10 mg/day until progression or unacceptable toxicity.	platinum	toxicity	19549709	-1
-METHODS: Stage IIIb or IV NSCLC patients, with two or fewer prior chemotherapy regimens, one platinum based (stratum 1) or both chemotherapy and epidermal growth factor receptor tyrosine kinase inhibitors (stratum 2), received RAD001 10 mg/day until progression or unacceptable toxicity.	platinum	NSCLC	19549709	-1
-PURPOSE: To determine the benefits and harms of taking aspirin for the primary prevention of myocardial infarctions, strokes, and death.	aspirin	myocardial infarctions	19293073	-1
-PURPOSE: To determine the benefits and harms of taking aspirin for the primary prevention of myocardial infarctions, strokes, and death.	aspirin	death	19293073	-1
-PURPOSE: To determine the benefits and harms of taking aspirin for the primary prevention of myocardial infarctions, strokes, and death.	aspirin	strokes	19293073	1
-Metfromin markedly lowered isoproterenol-induced elevation in the levels of TLR4 mRNA, myeloid differentiation protein 88 (MyD88), tumor necrosis factor-alpha (TNF-a), and interleukin 6 (IL-6) in the heart tissues.	isoproterenol	tumor	24842192	-1
-Metfromin markedly lowered isoproterenol-induced elevation in the levels of TLR4 mRNA, myeloid differentiation protein 88 (MyD88), tumor necrosis factor-alpha (TNF-a), and interleukin 6 (IL-6) in the heart tissues.	isoproterenol	necrosis	24842192	-1
-In 1 patient, marked hypertension was induced by propranolol and the drug had to be withdrawn.	propranolol	hypertension	611664	1
-A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir.	telaprevir	chronic hepatitis C virus infection	24927617	-1
-A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir.	pegylated interferon	chronic hepatitis C virus infection	24927617	-1
-A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir.	ribavirin	chronic hepatitis C virus infection	24927617	-1
-But before this event, she was taking zolmitriptan 2-3 times daily for several days because of a persistent migraine headache.	zolmitriptan 2-3	migraine headache	24100257	-1
-The compound manifests antiarrhythmic activity in all models of experimental arrhythmia used, causing greatest inhibition on the arrhythmia induced by chloroform-adrenaline (in 90 per cent) and with BaCl2 (in 84 per cent).	chloroform-adrenaline	arrhythmia	44072	1
-The compound manifests antiarrhythmic activity in all models of experimental arrhythmia used, causing greatest inhibition on the arrhythmia induced by chloroform-adrenaline (in 90 per cent) and with BaCl2 (in 84 per cent).	BaCl2	arrhythmia	44072	1
-The case shows that prolonged jaw rigidity and myalgia may occur after suxamethonium in patients with atypical cholinesterase despite pretreatment with pancuronium.	suxamethonium	jaw rigidity	7378868	-1
-The case shows that prolonged jaw rigidity and myalgia may occur after suxamethonium in patients with atypical cholinesterase despite pretreatment with pancuronium.	pancuronium	jaw rigidity	7378868	-1
-The case shows that prolonged jaw rigidity and myalgia may occur after suxamethonium in patients with atypical cholinesterase despite pretreatment with pancuronium.	pancuronium	myalgia	7378868	-1
-The topical application of a glycopyrrolate pad appeared to be safe, efficacious, well tolerated, and a convenient method of treatment for moderate to severe symptoms of gustatory hyperhidrosis in post transthoracic endoscopic sympathectomy or sympathicotomy patients, with few side effects.	glycopyrrolate	gustatory hyperhidrosis	12950111	-1
-Delirium in a patient with toxic flecainide plasma concentrations: the role of a pharmacokinetic drug interaction with paroxetine.	paroxetine	Delirium	19531695	1
-Two cases of propylthiouracil-associated acute hepatitis, one case of fatal methimazole-associated hepatocellular necrosis and one case of propylthiouracil-associated lupus-like syndrome are described.	methimazole	hepatitis	2484903	-1
-Two cases of propylthiouracil-associated acute hepatitis, one case of fatal methimazole-associated hepatocellular necrosis and one case of propylthiouracil-associated lupus-like syndrome are described.	methimazole	hepatocellular necrosis	2484903	-1
-Two cases of propylthiouracil-associated acute hepatitis, one case of fatal methimazole-associated hepatocellular necrosis and one case of propylthiouracil-associated lupus-like syndrome are described.	methimazole	lupus-like syndrome	2484903	-1
-Two cases of propylthiouracil-associated acute hepatitis, one case of fatal methimazole-associated hepatocellular necrosis and one case of propylthiouracil-associated lupus-like syndrome are described.	propylthiouracil	hepatitis	2484903	1
-Two cases of propylthiouracil-associated acute hepatitis, one case of fatal methimazole-associated hepatocellular necrosis and one case of propylthiouracil-associated lupus-like syndrome are described.	propylthiouracil	hepatocellular necrosis	2484903	-1
-Two cases of propylthiouracil-associated acute hepatitis, one case of fatal methimazole-associated hepatocellular necrosis and one case of propylthiouracil-associated lupus-like syndrome are described.	propylthiouracil	hepatocellular necrosis	2484903	-1
-Cytomegalovirus (CMV) shedding or serological rises in antibody titer, or both occurred in 78% of cyclosporine patients and 76% of Aza patients.	cyclosporine	Cytomegalovirus	6310832	-1
-Cytomegalovirus (CMV) shedding or serological rises in antibody titer, or both occurred in 78% of cyclosporine patients and 76% of Aza patients.	cyclosporine	CMV	6310832	-1
-Cytomegalovirus (CMV) shedding or serological rises in antibody titer, or both occurred in 78% of cyclosporine patients and 76% of Aza patients.	Aza	Cytomegalovirus	6310832	-1
-Cytomegalovirus (CMV) shedding or serological rises in antibody titer, or both occurred in 78% of cyclosporine patients and 76% of Aza patients.	Aza	CMV	6310832	-1
-Morphine-induced seizures in newborn infants.	Morphine	seizures	4082466	1
-The long-term safety of danazol in women with hereditary angioedema.	danazol	hereditary angioedema	2358093	-1
-OBJECTIVE: To describe a case of flecainide-induced delirium associated with a pharmacokinetic drug interaction with paroxetine.	paroxetine	delirium	19531695	1
-OBJECTIVE: To describe a case of flecainide-induced delirium associated with a pharmacokinetic drug interaction with paroxetine.	flecainide	delirium	19531695	1
-Cocaine induced no significant change in heart rate, LV dP/dt (positive or negative), or LV end-diastolic volume, but it caused an increase in systolic and mean arterial pressures, LV end-diastolic pressure, and LV end-systolic volume, as well as a decrease in LV ejection fraction.	Cocaine	LV	9570197	1
-Cocaine induced no significant change in heart rate, LV dP/dt (positive or negative), or LV end-diastolic volume, but it caused an increase in systolic and mean arterial pressures, LV end-diastolic pressure, and LV end-systolic volume, as well as a decrease in LV ejection fraction.	Cocaine	LV	9570197	1
-Cocaine induced no significant change in heart rate, LV dP/dt (positive or negative), or LV end-diastolic volume, but it caused an increase in systolic and mean arterial pressures, LV end-diastolic pressure, and LV end-systolic volume, as well as a decrease in LV ejection fraction.	Cocaine	LV	9570197	1
-Cocaine induced no significant change in heart rate, LV dP/dt (positive or negative), or LV end-diastolic volume, but it caused an increase in systolic and mean arterial pressures, LV end-diastolic pressure, and LV end-systolic volume, as well as a decrease in LV ejection fraction.	Cocaine	LV	9570197	1
-51 patients with medically refractory Parkinson's disease underwent stereotactic posteromedial pallidotomy between August 1993 and February 1997 for treatment of bradykinesia, rigidity, and L-DOPA-induced dyskinesias.	L-DOPA	rigidity	9782254	-1
-51 patients with medically refractory Parkinson's disease underwent stereotactic posteromedial pallidotomy between August 1993 and February 1997 for treatment of bradykinesia, rigidity, and L-DOPA-induced dyskinesias.	L-DOPA	Parkinson's disease	9782254	-1
-51 patients with medically refractory Parkinson's disease underwent stereotactic posteromedial pallidotomy between August 1993 and February 1997 for treatment of bradykinesia, rigidity, and L-DOPA-induced dyskinesias.	L-DOPA	dyskinesias	9782254	1
-51 patients with medically refractory Parkinson's disease underwent stereotactic posteromedial pallidotomy between August 1993 and February 1997 for treatment of bradykinesia, rigidity, and L-DOPA-induced dyskinesias.	L-DOPA	bradykinesia	9782254	-1
-We describe a female patient with stable Parkinson's disease who has shown a marked worsening of her motor functions following therapy of menopause related symptoms with veralipride, as well as the improvement of her symptoms back to baseline after discontinuation of the drug.	veralipride	Parkinson's disease	11299446	-1
-Prevention and treatment of endometrial disease in climacteric women receiving oestrogen therapy.	oestrogen	endometrial disease	89511	-1
-SUMMARY: A 63-year-old Caucasian man with renal amyloidosis undergoing peripheral blood stem cell collection for an autologous stem cell transplant developed extensive bilateral upper-extremity deep venous thrombosis (DVT) and pulmonary embolism secondary to heparin-induced thrombocytopenia.	heparin	DVT	24733133	1
-SUMMARY: A 63-year-old Caucasian man with renal amyloidosis undergoing peripheral blood stem cell collection for an autologous stem cell transplant developed extensive bilateral upper-extremity deep venous thrombosis (DVT) and pulmonary embolism secondary to heparin-induced thrombocytopenia.	heparin	thrombocytopenia	24733133	1
-SUMMARY: A 63-year-old Caucasian man with renal amyloidosis undergoing peripheral blood stem cell collection for an autologous stem cell transplant developed extensive bilateral upper-extremity deep venous thrombosis (DVT) and pulmonary embolism secondary to heparin-induced thrombocytopenia.	heparin	renal amyloidosis	24733133	-1
-BACKGROUND: Ifosfamide is an alkylating agent useful in the treatment of a wide range of cancers including sarcomas, lymphoma, gynecologic and testicular cancers.	Ifosfamide	cancers	24209900	-1
-BACKGROUND: Ifosfamide is an alkylating agent useful in the treatment of a wide range of cancers including sarcomas, lymphoma, gynecologic and testicular cancers.	Ifosfamide	cancers	24209900	-1
-BACKGROUND: Ifosfamide is an alkylating agent useful in the treatment of a wide range of cancers including sarcomas, lymphoma, gynecologic and testicular cancers.	Ifosfamide	lymphoma	24209900	-1
-BACKGROUND: Ifosfamide is an alkylating agent useful in the treatment of a wide range of cancers including sarcomas, lymphoma, gynecologic and testicular cancers.	Ifosfamide	sarcomas	24209900	-1
-Effects of ginsenosides on opioid-induced hyperalgesia in mice.	ginsenosides	hyperalgesia	24709919	-1
-Two neonates suffered from generalized seizures during the course of intravenous morphine sulfate for post-operative analgesia.	morphine sulfate	analgesia	4082466	-1
-Pentobarbital, scopolamine and MK-801 protected the brain damage by pilocarpine, though in the MK-801-treated group, the pyramidal cells of hippocampus appeared darker than normal.	Pentobarbital	brain damage	9061777	-1
-Pentobarbital, scopolamine and MK-801 protected the brain damage by pilocarpine, though in the MK-801-treated group, the pyramidal cells of hippocampus appeared darker than normal.	MK-801	brain damage	9061777	-1
-Pentobarbital, scopolamine and MK-801 protected the brain damage by pilocarpine, though in the MK-801-treated group, the pyramidal cells of hippocampus appeared darker than normal.	MK-801-treated	brain damage	9061777	-1
-Pentobarbital, scopolamine and MK-801 protected the brain damage by pilocarpine, though in the MK-801-treated group, the pyramidal cells of hippocampus appeared darker than normal.	pilocarpine	brain damage	9061777	-1
-Pentobarbital, scopolamine and MK-801 protected the brain damage by pilocarpine, though in the MK-801-treated group, the pyramidal cells of hippocampus appeared darker than normal.	scopolamine	brain damage	9061777	-1
-OBJECTIVES: To determine the incidence of major hemorrhage and stroke in people aged 76 and older with atrial fibrillation on adjusted-dose warfarin who had been recently been admitted to hospital.	warfarin	atrial fibrillation	15817013	-1
-OBJECTIVES: To determine the incidence of major hemorrhage and stroke in people aged 76 and older with atrial fibrillation on adjusted-dose warfarin who had been recently been admitted to hospital.	warfarin	hemorrhage	15817013	1
-OBJECTIVES: To determine the incidence of major hemorrhage and stroke in people aged 76 and older with atrial fibrillation on adjusted-dose warfarin who had been recently been admitted to hospital.	warfarin	stroke	15817013	-1
-DISCUSSION: Flecainide and pharmacologically similar agents that interact with sodium channels may cause delirium in susceptible patients.	sodium	delirium	19531695	-1
-The baby showed warfarin-induced embryopathy with nasal hypoplasia and stippled epiphyses (chondrodysplasia punctata).	warfarin	nasal hypoplasia	920167	-1
-The baby showed warfarin-induced embryopathy with nasal hypoplasia and stippled epiphyses (chondrodysplasia punctata).	warfarin	embryopathy	920167	-1
-In this study, we investigated the effects of Re, Rg1, and Rb1 ginsenosides, the bioactive components of ginseng, on OIH.	Rg1	OIH	24709919	-1
-In this study, we investigated the effects of Re, Rg1, and Rb1 ginsenosides, the bioactive components of ginseng, on OIH.	Rb1 ginsenosides	OIH	24709919	-1
-Serotonin reuptake inhibitors, paranoia, and the ventral basal ganglia.	Serotonin	paranoia	1837756	-1
-A MEDLINE search (1966-January 2009) revealed one in vivo pharmacokinetic study on the interaction between flecainide, a CYP2D6 substrate, and paroxetine, a CYP2D6 inhibitor, as well as 3 case reports of flecainide-induced delirium.	flecainide	delirium	19531695	1
-A MEDLINE search (1966-January 2009) revealed one in vivo pharmacokinetic study on the interaction between flecainide, a CYP2D6 substrate, and paroxetine, a CYP2D6 inhibitor, as well as 3 case reports of flecainide-induced delirium.	flecainide	delirium	19531695	1
-Sensitivity of cardiac component of baroreflex (CCB), expressed as a slope of the regression line was determined from relationships between systolic arterial pressure (SAP) and HR period (HRp) during phenylephrine (Phe)-induced hypertension and sodium nitroprusside (SN)-induced hypotension.	sodium nitroprusside	hypertension	8188982	-1
-Sensitivity of cardiac component of baroreflex (CCB), expressed as a slope of the regression line was determined from relationships between systolic arterial pressure (SAP) and HR period (HRp) during phenylephrine (Phe)-induced hypertension and sodium nitroprusside (SN)-induced hypotension.	sodium nitroprusside	hypotension	8188982	1
-Sensitivity of cardiac component of baroreflex (CCB), expressed as a slope of the regression line was determined from relationships between systolic arterial pressure (SAP) and HR period (HRp) during phenylephrine (Phe)-induced hypertension and sodium nitroprusside (SN)-induced hypotension.	SN)-induced	hypertension	8188982	-1
-Sensitivity of cardiac component of baroreflex (CCB), expressed as a slope of the regression line was determined from relationships between systolic arterial pressure (SAP) and HR period (HRp) during phenylephrine (Phe)-induced hypertension and sodium nitroprusside (SN)-induced hypotension.	phenylephrine	hypotension	8188982	-1
-Sensitivity of cardiac component of baroreflex (CCB), expressed as a slope of the regression line was determined from relationships between systolic arterial pressure (SAP) and HR period (HRp) during phenylephrine (Phe)-induced hypertension and sodium nitroprusside (SN)-induced hypotension.	Phe)-induced	hypertension	8188982	1
-Sensitivity of cardiac component of baroreflex (CCB), expressed as a slope of the regression line was determined from relationships between systolic arterial pressure (SAP) and HR period (HRp) during phenylephrine (Phe)-induced hypertension and sodium nitroprusside (SN)-induced hypotension.	Phe)-induced	hypotension	8188982	-1
-The effects on isoproterenol tachycardia were determined before and after atropine (0.04 mg/kg IV).	atropine	tachycardia	6299641	-1
-METHODS: Seventy-five patients with non-Hodgkin lymphoma treated with epirubicin were studied.	epirubicin	non-Hodgkin lymphoma	24464946	-1
-Re (300 mg/kg) inhibited OIH in both the thermal sensitivity test and the acetic acid-induced writhing test.	acetic acid	OIH	24709919	-1
-However, the Rg1 and Rb1 ginsenosides failed to prevent OIH in either test.	Rg1	OIH	24709919	-1
-However, the Rg1 and Rb1 ginsenosides failed to prevent OIH in either test.	Rb1 ginsenosides	OIH	24709919	-1
-All 36 patients receiving lamivudine had a decrease in hepatitis B virus (HBV) DNA values of >90% (P < .001 compared with placebo).	lamivudine	hepatitis B	8985298	-1
-No subject reported side effects of oxitropium, as compared to three subjects reporting nausea, vomiting and tremors after theophylline.	theophylline	nausea	3074291	1
-No subject reported side effects of oxitropium, as compared to three subjects reporting nausea, vomiting and tremors after theophylline.	theophylline	tremors	3074291	1
-No subject reported side effects of oxitropium, as compared to three subjects reporting nausea, vomiting and tremors after theophylline.	oxitropium	nausea	3074291	-1
-No subject reported side effects of oxitropium, as compared to three subjects reporting nausea, vomiting and tremors after theophylline.	oxitropium	tremors	3074291	-1
-No subject reported side effects of oxitropium, as compared to three subjects reporting nausea, vomiting and tremors after theophylline.	oxitropium	vomiting	3074291	-1
-Cerebrospinal fluid penetration of high-dose daptomycin in suspected Staphylococcus aureus meningitis.	daptomycin	Staphylococcus aureus meningitis	20959502	-1
-One of the major complications of cisplatin use is dose-limiting nephrotoxicity.	cisplatin	nephrotoxicity	24778426	-1
-OBJECTIVE: To highlight the role of electroencephalogram (EEG) in the early detection and management of ifosfamide related encephalopathy.	ifosfamide	encephalopathy	24209900	-1
-The changes in renal prostaglandin synthesis were accompanied by evidence of renal damage in aspirin-treated jj but not jJ rats as evidenced by: increased incidence and severity of hematuria (p less than 0.01); increased serum creatinine (p less than 0.05); and increase in outer medullary histopathologic lesions (p less than 0.005 compared to either sham-treated jj or aspirin-treated jJ).	prostaglandin	renal damage	3864191	-1
-The changes in renal prostaglandin synthesis were accompanied by evidence of renal damage in aspirin-treated jj but not jJ rats as evidenced by: increased incidence and severity of hematuria (p less than 0.01); increased serum creatinine (p less than 0.05); and increase in outer medullary histopathologic lesions (p less than 0.005 compared to either sham-treated jj or aspirin-treated jJ).	prostaglandin	hematuria	3864191	-1
-The changes in renal prostaglandin synthesis were accompanied by evidence of renal damage in aspirin-treated jj but not jJ rats as evidenced by: increased incidence and severity of hematuria (p less than 0.01); increased serum creatinine (p less than 0.05); and increase in outer medullary histopathologic lesions (p less than 0.005 compared to either sham-treated jj or aspirin-treated jJ).	creatinine	renal damage	3864191	-1
-The changes in renal prostaglandin synthesis were accompanied by evidence of renal damage in aspirin-treated jj but not jJ rats as evidenced by: increased incidence and severity of hematuria (p less than 0.01); increased serum creatinine (p less than 0.05); and increase in outer medullary histopathologic lesions (p less than 0.005 compared to either sham-treated jj or aspirin-treated jJ).	creatinine	hematuria	3864191	-1
-The changes in renal prostaglandin synthesis were accompanied by evidence of renal damage in aspirin-treated jj but not jJ rats as evidenced by: increased incidence and severity of hematuria (p less than 0.01); increased serum creatinine (p less than 0.05); and increase in outer medullary histopathologic lesions (p less than 0.005 compared to either sham-treated jj or aspirin-treated jJ).	aspirin	renal damage	3864191	1
-The changes in renal prostaglandin synthesis were accompanied by evidence of renal damage in aspirin-treated jj but not jJ rats as evidenced by: increased incidence and severity of hematuria (p less than 0.01); increased serum creatinine (p less than 0.05); and increase in outer medullary histopathologic lesions (p less than 0.005 compared to either sham-treated jj or aspirin-treated jJ).	aspirin	hematuria	3864191	-1
-The changes in renal prostaglandin synthesis were accompanied by evidence of renal damage in aspirin-treated jj but not jJ rats as evidenced by: increased incidence and severity of hematuria (p less than 0.01); increased serum creatinine (p less than 0.05); and increase in outer medullary histopathologic lesions (p less than 0.005 compared to either sham-treated jj or aspirin-treated jJ).	aspirin	hematuria	3864191	-1
-There are many strategies to prevent this toxicity, including the use of mannitol as a nephroprotectant in combination with hydration.	mannitol	toxicity	24778426	-1
-Electroencephalographic and behavioral monitoring revealed a profound reduction of the threshold for pilocarpine-induced convulsions.	pilocarpine	convulsions	3708328	1
-First, pretreatment with MK-801 produced an effective and dose-dependent anticonvulsant action with the lithium-pilocarpine model but not with rats treated with pilocarpine alone, suggesting that different biochemical mechanisms control seizures in these two models.	MK-801	seizures	2553470	-1
-First, pretreatment with MK-801 produced an effective and dose-dependent anticonvulsant action with the lithium-pilocarpine model but not with rats treated with pilocarpine alone, suggesting that different biochemical mechanisms control seizures in these two models.	lithium	seizures	2553470	-1
-First, pretreatment with MK-801 produced an effective and dose-dependent anticonvulsant action with the lithium-pilocarpine model but not with rats treated with pilocarpine alone, suggesting that different biochemical mechanisms control seizures in these two models.	pilocarpine	seizures	2553470	-1
-First, pretreatment with MK-801 produced an effective and dose-dependent anticonvulsant action with the lithium-pilocarpine model but not with rats treated with pilocarpine alone, suggesting that different biochemical mechanisms control seizures in these two models.	pilocarpine	seizures	2553470	-1
-OBJECTIVE: We aimed to evaluate the rates of cisplatin-induced nephrotoxicity in cancer patients receiving single-agent cisplatin with and without mannitol.	mannitol	cancer	24778426	-1
-OBJECTIVE: We aimed to evaluate the rates of cisplatin-induced nephrotoxicity in cancer patients receiving single-agent cisplatin with and without mannitol.	mannitol	nephrotoxicity	24778426	-1
-OBJECTIVE: We aimed to evaluate the rates of cisplatin-induced nephrotoxicity in cancer patients receiving single-agent cisplatin with and without mannitol.	cisplatin	cancer	24778426	-1
-OBJECTIVE: We aimed to evaluate the rates of cisplatin-induced nephrotoxicity in cancer patients receiving single-agent cisplatin with and without mannitol.	cisplatin	nephrotoxicity	24778426	-1
-OBJECTIVE: We aimed to evaluate the rates of cisplatin-induced nephrotoxicity in cancer patients receiving single-agent cisplatin with and without mannitol.	cisplatin	cancer	24778426	-1
-OBJECTIVE: We aimed to evaluate the rates of cisplatin-induced nephrotoxicity in cancer patients receiving single-agent cisplatin with and without mannitol.	cisplatin	nephrotoxicity	24778426	-1
-These results indicate that non-steroidal anti-inflammatory drugs differentially modulate the threshold for pilocarpine-induced seizures.	pilocarpine	seizures	3191389	1
-ACC-9653 and phenytoin sodium have similar antiarrhythmic activity against ouabain-induced ventricular tachycardia in anesthetized dogs.	ACC-9653	ventricular tachycardia	2767010	-1
-ACC-9653 and phenytoin sodium have similar antiarrhythmic activity against ouabain-induced ventricular tachycardia in anesthetized dogs.	ouabain	ventricular tachycardia	2767010	1
-ACC-9653 and phenytoin sodium have similar antiarrhythmic activity against ouabain-induced ventricular tachycardia in anesthetized dogs.	phenytoin sodium	ventricular tachycardia	2767010	-1
-As a function of dose, FZP first protected against convulsions and death.	FZP	convulsions	6106951	1
-As a function of dose, FZP first protected against convulsions and death.	FZP	death	6106951	-1
-CONCLUSIONS: RAD001 10 mg/day was well tolerated, showing modest clinical activity in pretreated NSCLC.	RAD001	NSCLC	19549709	-1
-A flurothyl ether seizure screening technique was used to evaluate seizure susceptibility in adult mice that received neonatal injections of MSG (4 mg/g and 1 mg/g).	flurothyl	seizure	3685052	-1
-A flurothyl ether seizure screening technique was used to evaluate seizure susceptibility in adult mice that received neonatal injections of MSG (4 mg/g and 1 mg/g).	flurothyl	seizure	3685052	-1
-Evaluation of RAD001 plus standard therapy for metastatic NSCLC continues.	RAD001	NSCLC	19549709	-1
-D-Glucarates were effective against renal damage induced by peptide antibiotics as well as various aminoglycoside antibitocis.	aminoglycoside	renal damage	931801	-1
-The encouraging results obtained in various authoratative departments in myopathic patients by using anabolizing steroids have encouraged the authors to investigate the beneficial effects of one anabolizing agent (Dianabol, CIBA) at high doses in rats rendered myopathic by a diet deficient in vitamin E.	Dianabol	myopathic	753803	-1
-The encouraging results obtained in various authoratative departments in myopathic patients by using anabolizing steroids have encouraged the authors to investigate the beneficial effects of one anabolizing agent (Dianabol, CIBA) at high doses in rats rendered myopathic by a diet deficient in vitamin E.	Dianabol	myopathic	753803	-1
-The encouraging results obtained in various authoratative departments in myopathic patients by using anabolizing steroids have encouraged the authors to investigate the beneficial effects of one anabolizing agent (Dianabol, CIBA) at high doses in rats rendered myopathic by a diet deficient in vitamin E.	steroids	myopathic	753803	-1
-The encouraging results obtained in various authoratative departments in myopathic patients by using anabolizing steroids have encouraged the authors to investigate the beneficial effects of one anabolizing agent (Dianabol, CIBA) at high doses in rats rendered myopathic by a diet deficient in vitamin E.	steroids	myopathic	753803	-1
-The encouraging results obtained in various authoratative departments in myopathic patients by using anabolizing steroids have encouraged the authors to investigate the beneficial effects of one anabolizing agent (Dianabol, CIBA) at high doses in rats rendered myopathic by a diet deficient in vitamin E.	vitamin	myopathic	753803	-1
-The encouraging results obtained in various authoratative departments in myopathic patients by using anabolizing steroids have encouraged the authors to investigate the beneficial effects of one anabolizing agent (Dianabol, CIBA) at high doses in rats rendered myopathic by a diet deficient in vitamin E.	vitamin	myopathic	753803	-1
-After admission, the patient received a continuous intravenous infusion of 5-FU (1000 mg/day), during which precordial pain with right bundle branch block occurred concomitantly with a high serum FBAL concentration of 1955 ng/ml.	5-FU	pain	16369751	-1
-After admission, the patient received a continuous intravenous infusion of 5-FU (1000 mg/day), during which precordial pain with right bundle branch block occurred concomitantly with a high serum FBAL concentration of 1955 ng/ml.	5-FU	right bundle branch block	16369751	1
-After admission, the patient received a continuous intravenous infusion of 5-FU (1000 mg/day), during which precordial pain with right bundle branch block occurred concomitantly with a high serum FBAL concentration of 1955 ng/ml.	FBAL	pain	16369751	-1
-After admission, the patient received a continuous intravenous infusion of 5-FU (1000 mg/day), during which precordial pain with right bundle branch block occurred concomitantly with a high serum FBAL concentration of 1955 ng/ml.	FBAL	right bundle branch block	16369751	-1
-This study was conducted to identify the factors contributing to ribavirin-induced anemia.	ribavirin	anemia	15482540	-1
-Intraperitoneal injection of pilocarpine (400 mg/kg) induced tonic and clonic seizure.	pilocarpine	clonic seizure	9061777	1
-Low doses of pilocarpine caused a pronounced enhancement of the catalepsy that was induced by the dopaminergic blocker, haloperidol.	haloperidol	catalepsy	3925479	1
-The use of aspirin for primary prevention increases the risk for major bleeding events, primarily gastrointestinal bleeding events, in both men and women.	aspirin	bleeding	19293073	-1
-The use of aspirin for primary prevention increases the risk for major bleeding events, primarily gastrointestinal bleeding events, in both men and women.	aspirin	gastrointestinal bleeding	19293073	1
-CONCLUSION: Losartan reduces the rate of progression of ADR-induced focal segmental glomerulosclerosis to end-stage renal disease in SHR.	ADR	glomerulosclerosis to end-stage renal disease	18987260	-1
-CONCLUSION: Losartan reduces the rate of progression of ADR-induced focal segmental glomerulosclerosis to end-stage renal disease in SHR.	Losartan	glomerulosclerosis to end-stage renal disease	18987260	-1
-We describe three patients in whom severe, life-threatening hyperkalemia and renal insufficiency developed after treatment of acute gouty arthritis with indomethacin.	indomethacin	gouty arthritis	7411769	-1
-We describe three patients in whom severe, life-threatening hyperkalemia and renal insufficiency developed after treatment of acute gouty arthritis with indomethacin.	indomethacin	hyperkalemia	7411769	1
-OBJECTIVE: To assess outcomes based on troponin positivity in patients with cocaine chest pain admitted for exclusion of MI.	cocaine	MI	12359538	1
-OBJECTIVE: To assess outcomes based on troponin positivity in patients with cocaine chest pain admitted for exclusion of MI.	cocaine	chest pain	12359538	-1
-METHODS: Eighty-eight patients with chronic hepatitis C who received interferon-alpha-2b at a dose of 6 MU administered intramuscularly for 24 weeks in combination with ribavirin administered orally at a dose of 600 mg or 800 mg participated in the study.	ribavirin	chronic hepatitis C	15482540	-1
-METHODS: Eighty-eight patients with chronic hepatitis C who received interferon-alpha-2b at a dose of 6 MU administered intramuscularly for 24 weeks in combination with ribavirin administered orally at a dose of 600 mg or 800 mg participated in the study.	interferon-alpha-2b	chronic hepatitis C	15482540	-1
-Flecainide had been started 2 weeks prior for atrial fibrillation.	Flecainide	atrial fibrillation	19531695	-1
-In this study, we have utilized a rat model of progressive doxorubicin (DOX)-induced cardiomyopathy, applying multiple approaches, including cardiac magnetic resonance imaging (MRI), to provide the most comprehensive characterization to date of the timecourse of serological, pathological, and functional events underlying this toxicity.	doxorubicin	cardiomyopathy	24675088	1
-In this study, we have utilized a rat model of progressive doxorubicin (DOX)-induced cardiomyopathy, applying multiple approaches, including cardiac magnetic resonance imaging (MRI), to provide the most comprehensive characterization to date of the timecourse of serological, pathological, and functional events underlying this toxicity.	doxorubicin	toxicity	24675088	-1
-In this study, we have utilized a rat model of progressive doxorubicin (DOX)-induced cardiomyopathy, applying multiple approaches, including cardiac magnetic resonance imaging (MRI), to provide the most comprehensive characterization to date of the timecourse of serological, pathological, and functional events underlying this toxicity.	DOX)-induced	cardiomyopathy	24675088	1
-In this study, we have utilized a rat model of progressive doxorubicin (DOX)-induced cardiomyopathy, applying multiple approaches, including cardiac magnetic resonance imaging (MRI), to provide the most comprehensive characterization to date of the timecourse of serological, pathological, and functional events underlying this toxicity.	DOX)-induced	toxicity	24675088	-1
-Oxidative damage precedes nitrative damage in adriamycin-induced cardiac mitochondrial injury.	adriamycin	cardiac mitochondrial injury	15605432	-1
-The following factors appear to predispose to the development of this complication: abnormal cerebrospinal dynamics related to the presence of central nervous system leukemia, and epidural cerebrospinal leakage; elevated cerebrospinal fluid methothexate concentration related to abnormal cerebrospinal fluid dynamics and to inappropriately high methotrexate doses based on body surface area calculations in older children and adults; the presence of neurotoxic preservatives in commercially available methotrexate preparations and diluents; and the use of methotrexate diluents of unphysiologic pH, ionic content and osmolarity.	methotrexate	cerebrospinal leakage	946593	-1
-The following factors appear to predispose to the development of this complication: abnormal cerebrospinal dynamics related to the presence of central nervous system leukemia, and epidural cerebrospinal leakage; elevated cerebrospinal fluid methothexate concentration related to abnormal cerebrospinal fluid dynamics and to inappropriately high methotrexate doses based on body surface area calculations in older children and adults; the presence of neurotoxic preservatives in commercially available methotrexate preparations and diluents; and the use of methotrexate diluents of unphysiologic pH, ionic content and osmolarity.	methotrexate	neurotoxic	946593	-1
-The following factors appear to predispose to the development of this complication: abnormal cerebrospinal dynamics related to the presence of central nervous system leukemia, and epidural cerebrospinal leakage; elevated cerebrospinal fluid methothexate concentration related to abnormal cerebrospinal fluid dynamics and to inappropriately high methotrexate doses based on body surface area calculations in older children and adults; the presence of neurotoxic preservatives in commercially available methotrexate preparations and diluents; and the use of methotrexate diluents of unphysiologic pH, ionic content and osmolarity.	methotrexate	leukemia	946593	-1
-The following factors appear to predispose to the development of this complication: abnormal cerebrospinal dynamics related to the presence of central nervous system leukemia, and epidural cerebrospinal leakage; elevated cerebrospinal fluid methothexate concentration related to abnormal cerebrospinal fluid dynamics and to inappropriately high methotrexate doses based on body surface area calculations in older children and adults; the presence of neurotoxic preservatives in commercially available methotrexate preparations and diluents; and the use of methotrexate diluents of unphysiologic pH, ionic content and osmolarity.	methotrexate	cerebrospinal leakage	946593	-1
-The following factors appear to predispose to the development of this complication: abnormal cerebrospinal dynamics related to the presence of central nervous system leukemia, and epidural cerebrospinal leakage; elevated cerebrospinal fluid methothexate concentration related to abnormal cerebrospinal fluid dynamics and to inappropriately high methotrexate doses based on body surface area calculations in older children and adults; the presence of neurotoxic preservatives in commercially available methotrexate preparations and diluents; and the use of methotrexate diluents of unphysiologic pH, ionic content and osmolarity.	methotrexate	neurotoxic	946593	-1
-The following factors appear to predispose to the development of this complication: abnormal cerebrospinal dynamics related to the presence of central nervous system leukemia, and epidural cerebrospinal leakage; elevated cerebrospinal fluid methothexate concentration related to abnormal cerebrospinal fluid dynamics and to inappropriately high methotrexate doses based on body surface area calculations in older children and adults; the presence of neurotoxic preservatives in commercially available methotrexate preparations and diluents; and the use of methotrexate diluents of unphysiologic pH, ionic content and osmolarity.	methotrexate	leukemia	946593	-1
-The following factors appear to predispose to the development of this complication: abnormal cerebrospinal dynamics related to the presence of central nervous system leukemia, and epidural cerebrospinal leakage; elevated cerebrospinal fluid methothexate concentration related to abnormal cerebrospinal fluid dynamics and to inappropriately high methotrexate doses based on body surface area calculations in older children and adults; the presence of neurotoxic preservatives in commercially available methotrexate preparations and diluents; and the use of methotrexate diluents of unphysiologic pH, ionic content and osmolarity.	methotrexate	cerebrospinal leakage	946593	-1
-The following factors appear to predispose to the development of this complication: abnormal cerebrospinal dynamics related to the presence of central nervous system leukemia, and epidural cerebrospinal leakage; elevated cerebrospinal fluid methothexate concentration related to abnormal cerebrospinal fluid dynamics and to inappropriately high methotrexate doses based on body surface area calculations in older children and adults; the presence of neurotoxic preservatives in commercially available methotrexate preparations and diluents; and the use of methotrexate diluents of unphysiologic pH, ionic content and osmolarity.	methotrexate	neurotoxic	946593	-1
-The following factors appear to predispose to the development of this complication: abnormal cerebrospinal dynamics related to the presence of central nervous system leukemia, and epidural cerebrospinal leakage; elevated cerebrospinal fluid methothexate concentration related to abnormal cerebrospinal fluid dynamics and to inappropriately high methotrexate doses based on body surface area calculations in older children and adults; the presence of neurotoxic preservatives in commercially available methotrexate preparations and diluents; and the use of methotrexate diluents of unphysiologic pH, ionic content and osmolarity.	methotrexate	leukemia	946593	-1
-This study shows that MIP synthase inhibition does not replicate or augment the effects of lithium in the inositol sensitive pilocarpine-induced seizures model.	lithium	seizures	17828434	-1
-RESULTS: Ribavirin-induced anemia occurred in 18 (20.5%) patients during treatment.	Ribavirin	anemia	15482540	-1
-CONCLUSIONS: Aerosolized crack cocaine use can be associated with the development of corneal ulcers.	cocaine	corneal ulcers	17721298	-1
-When the total busulfan dose was taken into account, there was a significant difference in terms of neurotoxicity incidence among patients under 16 mg/kg (1 of 57, 1.7%) and patients under 600 mg/m2 (6 of 39, 15.4%) (P less than 0.02).	busulfan	neurotoxicity	2400986	-1
-In conclusion, ouabain-induced mania-like behavior may provide a useful animal model to test the hypothesis of the involvement of oxidative stress in bipolar disorder.	ouabain	mania	19447152	1
-On the other hand, nocistatin is recently isolated from the same precursor as nociceptin and blocks nociceptin-induced allodynia and hyperalgesia.	nocistatin	allodynia	10401555	-1
-On the other hand, nocistatin is recently isolated from the same precursor as nociceptin and blocks nociceptin-induced allodynia and hyperalgesia.	nocistatin	hyperalgesia	10401555	-1
-On the other hand, nocistatin is recently isolated from the same precursor as nociceptin and blocks nociceptin-induced allodynia and hyperalgesia.	nociceptin	allodynia	10401555	-1
-On the other hand, nocistatin is recently isolated from the same precursor as nociceptin and blocks nociceptin-induced allodynia and hyperalgesia.	nociceptin	hyperalgesia	10401555	-1
-On the other hand, nocistatin is recently isolated from the same precursor as nociceptin and blocks nociceptin-induced allodynia and hyperalgesia.	nociceptin	allodynia	10401555	-1
-On the other hand, nocistatin is recently isolated from the same precursor as nociceptin and blocks nociceptin-induced allodynia and hyperalgesia.	nociceptin	hyperalgesia	10401555	-1
-Cyclophosphamide cardiotoxicity: an analysis of dosing as a risk factor.	Cyclophosphamide	cardiotoxicity	3533179	-1
-Tumor regression was observed with 0.5 mg doxorubicin/kg. Complete disappearance of the tumor was induced with 1.0 mg doxorubicin/kg.	doxorubicin	Tumor	6585590	-1
-Tumor regression was observed with 0.5 mg doxorubicin/kg. Complete disappearance of the tumor was induced with 1.0 mg doxorubicin/kg.	doxorubicin	tumor	6585590	-1
-Tumor regression was observed with 0.5 mg doxorubicin/kg. Complete disappearance of the tumor was induced with 1.0 mg doxorubicin/kg.	doxorubicin	Tumor	6585590	-1
-Tumor regression was observed with 0.5 mg doxorubicin/kg. Complete disappearance of the tumor was induced with 1.0 mg doxorubicin/kg.	doxorubicin	tumor	6585590	-1
-Our data showed ADR induced 4HNE-protein adducts in mitochondria at the same time point as when mitochondrial injury initially appeared.	ADR	mitochondrial injury	15605432	1
-Significantly more P9605 patients developed leukoencephalopathy compared with P9201 patients (68%, 95% confidence interval 49%-83% vs. 22%, 95% confidence interval 5%-44%; P=0.001) identified as late as 7.7 years after the end of treatment.	P9605	leukoencephalopathy	24345882	-1
-Our results suggest a role for levodopa in the oral phase of deglutition and confirm that dysphagia is not a good predictor of deglutition alterations in PD.	levodopa	PD	15625689	-1
-Our results suggest a role for levodopa in the oral phase of deglutition and confirm that dysphagia is not a good predictor of deglutition alterations in PD.	levodopa	dysphagia	15625689	-1
-After adjustment for age, the rate ratio of VTE in users of third-generation relative to second-generation OCs was 1.68 (95% CI 1.04-2.75).	OCs	VTE	8996419	1
-OBJECTIVES: To investigate the effects of subchronic L-NOARG treatment in haloperidol-induced catalepsy and the number of NOS neurons in areas related to motor control.	haloperidol	catalepsy	10672628	1
-The improvement in GFR was not associated with enhanced glomerular hypertrophy or increased segmental glomerulosclerosis, tubulointerstitial injury, or renal cortical malondialdehyde content.	malondialdehyde	glomerulosclerosis	8825380	-1
-The improvement in GFR was not associated with enhanced glomerular hypertrophy or increased segmental glomerulosclerosis, tubulointerstitial injury, or renal cortical malondialdehyde content.	malondialdehyde	glomerular hypertrophy	8825380	-1
-A postmarketing surveillance study was conducted to determine the safety and efficacy of a fixed-ratio combination containing 10 mg of timolol maleate and 25 mg of hydrochlorothiazide, administered twice daily for one month to hypertensive patients.	hydrochlorothiazide	hypertensive	3833372	-1
-A postmarketing surveillance study was conducted to determine the safety and efficacy of a fixed-ratio combination containing 10 mg of timolol maleate and 25 mg of hydrochlorothiazide, administered twice daily for one month to hypertensive patients.	timolol maleate	hypertensive	3833372	-1
-Antidepressants have previously been associated with paranoid reactions in psychiatric patients.	Antidepressants	psychiatric	1837756	-1
-High-dose 5-fluorouracil / folinic acid in combination with three-weekly mitomycin C in the treatment of advanced gastric cancer.	5-fluorouracil	gastric cancer	12119460	-1
-High-dose 5-fluorouracil / folinic acid in combination with three-weekly mitomycin C in the treatment of advanced gastric cancer.	folinic acid	gastric cancer	12119460	-1
-High-dose 5-fluorouracil / folinic acid in combination with three-weekly mitomycin C in the treatment of advanced gastric cancer.	mitomycin C	gastric cancer	12119460	-1
-Hypotension induced by both peptides was significantly attenuated by glibenclamide, which abolished a levcromakalim-produced decrease in arterial blood pressure.	glibenclamide	Hypotension	9881641	-1
-Acute renal failure due to rifampicin.	rifampicin	Acute renal failure	2083961	1
-BACKGROUND: The 24-hour continuous infusion of 5-fluorouracil (5-FU) and folinic acid (FA) as part of several new multidrug chemotherapy regimens in advanced gastric cancer (AGC) has shown to be effective, with low toxicity.	5-fluorouracil	low toxicity	12119460	-1
-BACKGROUND: The 24-hour continuous infusion of 5-fluorouracil (5-FU) and folinic acid (FA) as part of several new multidrug chemotherapy regimens in advanced gastric cancer (AGC) has shown to be effective, with low toxicity.	5-fluorouracil	gastric cancer	12119460	-1
-BACKGROUND: The 24-hour continuous infusion of 5-fluorouracil (5-FU) and folinic acid (FA) as part of several new multidrug chemotherapy regimens in advanced gastric cancer (AGC) has shown to be effective, with low toxicity.	5-fluorouracil	AGC	12119460	-1
-BACKGROUND: The 24-hour continuous infusion of 5-fluorouracil (5-FU) and folinic acid (FA) as part of several new multidrug chemotherapy regimens in advanced gastric cancer (AGC) has shown to be effective, with low toxicity.	5-FU	low toxicity	12119460	-1
-BACKGROUND: The 24-hour continuous infusion of 5-fluorouracil (5-FU) and folinic acid (FA) as part of several new multidrug chemotherapy regimens in advanced gastric cancer (AGC) has shown to be effective, with low toxicity.	5-FU	gastric cancer	12119460	-1
-BACKGROUND: The 24-hour continuous infusion of 5-fluorouracil (5-FU) and folinic acid (FA) as part of several new multidrug chemotherapy regimens in advanced gastric cancer (AGC) has shown to be effective, with low toxicity.	5-FU	AGC	12119460	-1
-BACKGROUND: The 24-hour continuous infusion of 5-fluorouracil (5-FU) and folinic acid (FA) as part of several new multidrug chemotherapy regimens in advanced gastric cancer (AGC) has shown to be effective, with low toxicity.	folinic acid	low toxicity	12119460	-1
-BACKGROUND: The 24-hour continuous infusion of 5-fluorouracil (5-FU) and folinic acid (FA) as part of several new multidrug chemotherapy regimens in advanced gastric cancer (AGC) has shown to be effective, with low toxicity.	folinic acid	gastric cancer	12119460	-1
-BACKGROUND: The 24-hour continuous infusion of 5-fluorouracil (5-FU) and folinic acid (FA) as part of several new multidrug chemotherapy regimens in advanced gastric cancer (AGC) has shown to be effective, with low toxicity.	folinic acid	AGC	12119460	-1
-BACKGROUND: The 24-hour continuous infusion of 5-fluorouracil (5-FU) and folinic acid (FA) as part of several new multidrug chemotherapy regimens in advanced gastric cancer (AGC) has shown to be effective, with low toxicity.	FA	low toxicity	12119460	-1
-BACKGROUND: The 24-hour continuous infusion of 5-fluorouracil (5-FU) and folinic acid (FA) as part of several new multidrug chemotherapy regimens in advanced gastric cancer (AGC) has shown to be effective, with low toxicity.	FA	gastric cancer	12119460	-1
-BACKGROUND: The 24-hour continuous infusion of 5-fluorouracil (5-FU) and folinic acid (FA) as part of several new multidrug chemotherapy regimens in advanced gastric cancer (AGC) has shown to be effective, with low toxicity.	FA	AGC	12119460	-1
-Percutaneous absorption of warfarin causing coagulopathy, reported three times in the past, is a significant risk if protective measures, such as gloves, are not used.	warfarin	coagulopathy	8308951	-1
-In a previous phase II study with 3-weekly bolus 5-FU, FA and mitomycin C (MMC) we found a low toxicity rate and response rates comparable to those of regimens such as ELF, FAM or FAMTX, and a promising median overall survival.	FAMTX	toxicity	12119460	-1
-In a previous phase II study with 3-weekly bolus 5-FU, FA and mitomycin C (MMC) we found a low toxicity rate and response rates comparable to those of regimens such as ELF, FAM or FAMTX, and a promising median overall survival.	5-FU	toxicity	12119460	-1
-In a previous phase II study with 3-weekly bolus 5-FU, FA and mitomycin C (MMC) we found a low toxicity rate and response rates comparable to those of regimens such as ELF, FAM or FAMTX, and a promising median overall survival.	FAM	toxicity	12119460	-1
-In a previous phase II study with 3-weekly bolus 5-FU, FA and mitomycin C (MMC) we found a low toxicity rate and response rates comparable to those of regimens such as ELF, FAM or FAMTX, and a promising median overall survival.	FA	toxicity	12119460	-1
-In a previous phase II study with 3-weekly bolus 5-FU, FA and mitomycin C (MMC) we found a low toxicity rate and response rates comparable to those of regimens such as ELF, FAM or FAMTX, and a promising median overall survival.	mitomycin C	toxicity	12119460	-1
-In a previous phase II study with 3-weekly bolus 5-FU, FA and mitomycin C (MMC) we found a low toxicity rate and response rates comparable to those of regimens such as ELF, FAM or FAMTX, and a promising median overall survival.	MMC	toxicity	12119460	-1
-LIMITATIONS: New evidence on aspirin for the primary prevention of CVD is limited.	aspirin	CVD	19293073	-1
-Aconitine-induced Ca2+ overload causes arrhythmia and triggers apoptosis through p38 MAPK signaling pathway in rats.	Aconitine	arrhythmia	24840785	1
-Aconitine-induced Ca2+ overload causes arrhythmia and triggers apoptosis through p38 MAPK signaling pathway in rats.	Ca2	arrhythmia	24840785	-1
-Chronic hyperprolactinemia and changes in dopamine neurons.	dopamine	hyperprolactinemia	9128918	-1
-An alternate class III agent, sotalol, was also effective for the prevention of VT.	sotalol	VT	15609701	-1
-From February, 1998 to September, 2000 we recruited 33 patients with AGC to receive weekly 24-hour 5-FU 2,600 mg/m(2) preceded by 2-hour FA 500 mg/m(2) for 6 weeks, followed by a 2-week rest period.	5-FU	AGC	12119460	-1
-From February, 1998 to September, 2000 we recruited 33 patients with AGC to receive weekly 24-hour 5-FU 2,600 mg/m(2) preceded by 2-hour FA 500 mg/m(2) for 6 weeks, followed by a 2-week rest period.	FA	AGC	12119460	-1
-OBJECTIVE: To report a case of methicillin-sensitive Staphylococcus aureus (MSSA) bacteremia with suspected MSSA meningitis treated with high-dose daptomycin assessed with concurrent serum and cerebrospinal fluid (CSF) concentrations.	daptomycin	bacteremia	20959502	-1
-OBJECTIVE: To report a case of methicillin-sensitive Staphylococcus aureus (MSSA) bacteremia with suspected MSSA meningitis treated with high-dose daptomycin assessed with concurrent serum and cerebrospinal fluid (CSF) concentrations.	daptomycin	meningitis	20959502	-1
-OBJECTIVE: To report a case of methicillin-sensitive Staphylococcus aureus (MSSA) bacteremia with suspected MSSA meningitis treated with high-dose daptomycin assessed with concurrent serum and cerebrospinal fluid (CSF) concentrations.	methicillin	bacteremia	20959502	-1
-OBJECTIVE: To report a case of methicillin-sensitive Staphylococcus aureus (MSSA) bacteremia with suspected MSSA meningitis treated with high-dose daptomycin assessed with concurrent serum and cerebrospinal fluid (CSF) concentrations.	methicillin	meningitis	20959502	-1
-OBJECTIVE: To report a case of methicillin-sensitive Staphylococcus aureus (MSSA) bacteremia with suspected MSSA meningitis treated with high-dose daptomycin assessed with concurrent serum and cerebrospinal fluid (CSF) concentrations.	MSSA	bacteremia	20959502	-1
-OBJECTIVE: To report a case of methicillin-sensitive Staphylococcus aureus (MSSA) bacteremia with suspected MSSA meningitis treated with high-dose daptomycin assessed with concurrent serum and cerebrospinal fluid (CSF) concentrations.	MSSA	meningitis	20959502	-1
-OBJECTIVE: To review the natural history and ocular and systemic adverse effects of patients taking hydroxychloroquine sulfate who attended an ophthalmic screening program.	hydroxychloroquine	ocular	17159032	-1
-BACKGROUND: Four studies published since December, 1995, reported that the incidence of venous thromboembolism (VTE) was higher in women who used oral contraceptives (OCs) containing the third-generation progestagens gestodene or desogestrel than in users of OCs containing second-generation progestagens.	progestagens	venous thromboembolism	8996419	-1
-BACKGROUND: Four studies published since December, 1995, reported that the incidence of venous thromboembolism (VTE) was higher in women who used oral contraceptives (OCs) containing the third-generation progestagens gestodene or desogestrel than in users of OCs containing second-generation progestagens.	progestagens	VTE	8996419	-1
-BACKGROUND: Four studies published since December, 1995, reported that the incidence of venous thromboembolism (VTE) was higher in women who used oral contraceptives (OCs) containing the third-generation progestagens gestodene or desogestrel than in users of OCs containing second-generation progestagens.	desogestrel	venous thromboembolism	8996419	-1
-BACKGROUND: Four studies published since December, 1995, reported that the incidence of venous thromboembolism (VTE) was higher in women who used oral contraceptives (OCs) containing the third-generation progestagens gestodene or desogestrel than in users of OCs containing second-generation progestagens.	desogestrel	VTE	8996419	-1
-BACKGROUND: Four studies published since December, 1995, reported that the incidence of venous thromboembolism (VTE) was higher in women who used oral contraceptives (OCs) containing the third-generation progestagens gestodene or desogestrel than in users of OCs containing second-generation progestagens.	progestagens gestodene	venous thromboembolism	8996419	-1
-BACKGROUND: Four studies published since December, 1995, reported that the incidence of venous thromboembolism (VTE) was higher in women who used oral contraceptives (OCs) containing the third-generation progestagens gestodene or desogestrel than in users of OCs containing second-generation progestagens.	progestagens gestodene	VTE	8996419	-1
-BACKGROUND: Four studies published since December, 1995, reported that the incidence of venous thromboembolism (VTE) was higher in women who used oral contraceptives (OCs) containing the third-generation progestagens gestodene or desogestrel than in users of OCs containing second-generation progestagens.	oral contraceptives	venous thromboembolism	8996419	1
-BACKGROUND: Four studies published since December, 1995, reported that the incidence of venous thromboembolism (VTE) was higher in women who used oral contraceptives (OCs) containing the third-generation progestagens gestodene or desogestrel than in users of OCs containing second-generation progestagens.	OCs	venous thromboembolism	8996419	1
-BACKGROUND: Four studies published since December, 1995, reported that the incidence of venous thromboembolism (VTE) was higher in women who used oral contraceptives (OCs) containing the third-generation progestagens gestodene or desogestrel than in users of OCs containing second-generation progestagens.	OCs	VTE	8996419	1
-BACKGROUND: Four studies published since December, 1995, reported that the incidence of venous thromboembolism (VTE) was higher in women who used oral contraceptives (OCs) containing the third-generation progestagens gestodene or desogestrel than in users of OCs containing second-generation progestagens.	OCs	VTE	8996419	1
-Deliberate hypotension induced by labetalol with halothane, enflurane or isoflurane for middle-ear surgery.	enflurane	hypotension	2718706	1
-Deliberate hypotension induced by labetalol with halothane, enflurane or isoflurane for middle-ear surgery.	labetalol	hypotension	2718706	1
-Deliberate hypotension induced by labetalol with halothane, enflurane or isoflurane for middle-ear surgery.	isoflurane	hypotension	2718706	1
-Lindane (gamma-hexachlorocyclohexane) is an organochlorine insecticide with known neurotoxic effects.	Lindane	neurotoxic	2453942	-1
-Lindane (gamma-hexachlorocyclohexane) is an organochlorine insecticide with known neurotoxic effects.	gamma-hexachlorocyclohexane	neurotoxic	2453942	-1
-Lindane (gamma-hexachlorocyclohexane) is an organochlorine insecticide with known neurotoxic effects.	organochlorine	neurotoxic	2453942	-1
-The present study was designed to answer these questions, using a rodent model of early childhood Pb exposure and treatment with succimer, a widely used chelating agent for the treatment of Pb poisoning.	Pb	poisoning	17384765	-1
-The present study was designed to answer these questions, using a rodent model of early childhood Pb exposure and treatment with succimer, a widely used chelating agent for the treatment of Pb poisoning.	Pb	poisoning	17384765	-1
-Busulfan levels were measured by a gas chromatographic-mass spectrometry assay in the plasma and cerebrospinal fluid of 9 children without central nervous system disease under 600 mg/m2 busulfan with clonazepam:busulfan cerebrospinal fluid:plasma ratio was 1.39.	Busulfan	nervous system disease	2400986	-1
-Busulfan levels were measured by a gas chromatographic-mass spectrometry assay in the plasma and cerebrospinal fluid of 9 children without central nervous system disease under 600 mg/m2 busulfan with clonazepam:busulfan cerebrospinal fluid:plasma ratio was 1.39.	busulfan	nervous system disease	2400986	-1
-Busulfan levels were measured by a gas chromatographic-mass spectrometry assay in the plasma and cerebrospinal fluid of 9 children without central nervous system disease under 600 mg/m2 busulfan with clonazepam:busulfan cerebrospinal fluid:plasma ratio was 1.39.	busulfan	nervous system disease	2400986	-1
-Busulfan levels were measured by a gas chromatographic-mass spectrometry assay in the plasma and cerebrospinal fluid of 9 children without central nervous system disease under 600 mg/m2 busulfan with clonazepam:busulfan cerebrospinal fluid:plasma ratio was 1.39.	clonazepam	nervous system disease	2400986	-1
-During hypotension, the serum creatinine concentration rose significantly in all groups from the values before hypotension and returned postoperatively to the initial level in the other groups, except the isoflurane group.	creatinine	hypotension	2718706	-1
-During hypotension, the serum creatinine concentration rose significantly in all groups from the values before hypotension and returned postoperatively to the initial level in the other groups, except the isoflurane group.	creatinine	hypotension	2718706	-1
-During hypotension, the serum creatinine concentration rose significantly in all groups from the values before hypotension and returned postoperatively to the initial level in the other groups, except the isoflurane group.	isoflurane	hypotension	2718706	1
-The worst toxicities (%) observed were (CTC-NCI 1/2/3): leukopenia 45.5/18.2/6.1, thrombocytopenia 33.3/9.1/6.1, vomitus 24.2/9.1/0, diarrhea 36.4/6.1/3.0, stomatitis 18.2/9.1/0, hand-foot syndrome 12.1/0/0.	CTC	hand-foot syndrome	12119460	-1
-The worst toxicities (%) observed were (CTC-NCI 1/2/3): leukopenia 45.5/18.2/6.1, thrombocytopenia 33.3/9.1/6.1, vomitus 24.2/9.1/0, diarrhea 36.4/6.1/3.0, stomatitis 18.2/9.1/0, hand-foot syndrome 12.1/0/0.	CTC	thrombocytopenia	12119460	-1
-The worst toxicities (%) observed were (CTC-NCI 1/2/3): leukopenia 45.5/18.2/6.1, thrombocytopenia 33.3/9.1/6.1, vomitus 24.2/9.1/0, diarrhea 36.4/6.1/3.0, stomatitis 18.2/9.1/0, hand-foot syndrome 12.1/0/0.	CTC	toxicities	12119460	-1
-The worst toxicities (%) observed were (CTC-NCI 1/2/3): leukopenia 45.5/18.2/6.1, thrombocytopenia 33.3/9.1/6.1, vomitus 24.2/9.1/0, diarrhea 36.4/6.1/3.0, stomatitis 18.2/9.1/0, hand-foot syndrome 12.1/0/0.	CTC	stomatitis	12119460	-1
-The worst toxicities (%) observed were (CTC-NCI 1/2/3): leukopenia 45.5/18.2/6.1, thrombocytopenia 33.3/9.1/6.1, vomitus 24.2/9.1/0, diarrhea 36.4/6.1/3.0, stomatitis 18.2/9.1/0, hand-foot syndrome 12.1/0/0.	CTC	leukopenia	12119460	-1
-The worst toxicities (%) observed were (CTC-NCI 1/2/3): leukopenia 45.5/18.2/6.1, thrombocytopenia 33.3/9.1/6.1, vomitus 24.2/9.1/0, diarrhea 36.4/6.1/3.0, stomatitis 18.2/9.1/0, hand-foot syndrome 12.1/0/0.	CTC	diarrhea	12119460	-1
-CONCLUSIONS: Despite a high prevalence of psychiatric disturbance, outcomes for patients transplanted emergently for acetaminophen-induced ALF were comparable to those transplanted for non-acetaminophen-induced ALF and electively for CLD.	acetaminophen	psychiatric disturbance	20408947	-1
-CONCLUSIONS: Despite a high prevalence of psychiatric disturbance, outcomes for patients transplanted emergently for acetaminophen-induced ALF were comparable to those transplanted for non-acetaminophen-induced ALF and electively for CLD.	acetaminophen	ALF	20408947	1
-CONCLUSIONS: Despite a high prevalence of psychiatric disturbance, outcomes for patients transplanted emergently for acetaminophen-induced ALF were comparable to those transplanted for non-acetaminophen-induced ALF and electively for CLD.	acetaminophen	ALF	20408947	1
-CONCLUSIONS: Despite a high prevalence of psychiatric disturbance, outcomes for patients transplanted emergently for acetaminophen-induced ALF were comparable to those transplanted for non-acetaminophen-induced ALF and electively for CLD.	acetaminophen	CLD	20408947	-1
-CONCLUSIONS: Despite a high prevalence of psychiatric disturbance, outcomes for patients transplanted emergently for acetaminophen-induced ALF were comparable to those transplanted for non-acetaminophen-induced ALF and electively for CLD.	acetaminophen	psychiatric disturbance	20408947	-1
-CONCLUSIONS: Despite a high prevalence of psychiatric disturbance, outcomes for patients transplanted emergently for acetaminophen-induced ALF were comparable to those transplanted for non-acetaminophen-induced ALF and electively for CLD.	acetaminophen	ALF	20408947	1
-CONCLUSIONS: Despite a high prevalence of psychiatric disturbance, outcomes for patients transplanted emergently for acetaminophen-induced ALF were comparable to those transplanted for non-acetaminophen-induced ALF and electively for CLD.	acetaminophen	CLD	20408947	-1
-Thirty-five patients (13.4%) had visual field abnormalities, which were attributed to hydroxychloroquine treatment in 4 patients (1.5%).	hydroxychloroquine	visual field abnormalities	17159032	-1
-In patients with various chest pain syndromes, verapamil neither increased the frequency of junctional rhythms nor suppressed their role as escape rhythms under physiologically appropriate circumstances.	verapamil	chest pain	6695685	-1
-To our knowledge, this is the first published case report of severe neurotoxicity caused by nelarabine in a patient who received concurrent IT chemotherapy.	nelarabine	neurotoxicity	24664478	-1
-Heparin-induced thrombocytopenia: a practical review.	Heparin	thrombocytopenia	20495512	1
-Scopolamine (10 mg/kg) and pentobarbital (5 mg/kg) prevented development of pilocarpine-induced behavioral seizure but MK-801 (0.5 mg/kg) did not.	pentobarbital	seizure	9061777	-1
-Scopolamine (10 mg/kg) and pentobarbital (5 mg/kg) prevented development of pilocarpine-induced behavioral seizure but MK-801 (0.5 mg/kg) did not.	MK-801	seizure	9061777	1
-Scopolamine (10 mg/kg) and pentobarbital (5 mg/kg) prevented development of pilocarpine-induced behavioral seizure but MK-801 (0.5 mg/kg) did not.	Scopolamine	seizure	9061777	-1
-Increase in intragastric pressure during suxamethonium-induced muscle fasciculations in children: inhibition by alfentanil.	alfentanil	muscle fasciculations	3125850	-1
-Increase in intragastric pressure during suxamethonium-induced muscle fasciculations in children: inhibition by alfentanil.	suxamethonium	muscle fasciculations	3125850	1
-CONCLUSIONS: Severity of ifosfamide related encephalopathy correlates with EEG changes.	ifosfamide	encephalopathy	24209900	-1
-High-dose 5-FU/FA/MMC is an effective and well-tolerated outpatient regimen for AGC (objective response rate 54.6%).	5-FU	AGC	12119460	-1
-High-dose 5-FU/FA/MMC is an effective and well-tolerated outpatient regimen for AGC (objective response rate 54.6%).	FA	AGC	12119460	-1
-High-dose 5-FU/FA/MMC is an effective and well-tolerated outpatient regimen for AGC (objective response rate 54.6%).	MMC	AGC	12119460	-1
-Pulmonary edema and shock after high-dose aracytine-C for lymphoma; possible role of TNF-alpha and PAF.	aracytine	Pulmonary edema	8318674	1
-Pulmonary edema and shock after high-dose aracytine-C for lymphoma; possible role of TNF-alpha and PAF.	aracytine	lymphoma	8318674	-1
-The incidence of hypokalemia was lower with VAL/HCTZ combinations (1.8%-6.1%) than with HCTZ monotherapies (7.1%-13.3%).	HCTZ	hypokalemia	17379047	1
-The incidence of hypokalemia was lower with VAL/HCTZ combinations (1.8%-6.1%) than with HCTZ monotherapies (7.1%-13.3%).	VAL	hypokalemia	17379047	-1
-Topical 0.025% capsaicin in chronic post-herpetic neuralgia: efficacy, predictors of response and long-term course.	capsaicin	neuralgia	1779253	-1
-Patients with anxiety disorders may benefit by avoiding caffeine-containing foods and beverages.	caffeine	anxiety disorders	2983630	1
-We therefore investigated the long-term safety of danazol by performing a retrospective chart review of 60 female patients with hereditary angioedema treated with danazol for a continuous period of 6 months or longer.	danazol	hereditary angioedema	2358093	-1
-We therefore investigated the long-term safety of danazol by performing a retrospective chart review of 60 female patients with hereditary angioedema treated with danazol for a continuous period of 6 months or longer.	danazol	hereditary angioedema	2358093	-1
-These findings suggest that helodermin-produced hypotension is partly attributable to the activation of glibenclamide-sensitive K+ channels (K(ATP) channels), which presumably exist on arterial smooth muscle cells.	glibenclamide	hypotension	9881641	-1
-These findings suggest that helodermin-produced hypotension is partly attributable to the activation of glibenclamide-sensitive K+ channels (K(ATP) channels), which presumably exist on arterial smooth muscle cells.	K+	hypotension	9881641	-1
-These findings suggest that helodermin-produced hypotension is partly attributable to the activation of glibenclamide-sensitive K+ channels (K(ATP) channels), which presumably exist on arterial smooth muscle cells.	K(ATP	hypotension	9881641	-1
-RESULTS: Four patients with corneal ulcers associated with crack cocaine use were reviewed.	crack cocaine	corneal ulcers	17721298	1
-During the 1-hour study period, the incidence of central nervous system side effects was significantly greater in the lidocaine group, hypotension occurred in 11 patients, nine of whom had received lidocaine, and four patients died from asystole, three of whom had had lidocaine. We cannot advocate the administration of lidocaine prophylactically in the early hours of suspected myocardial infarction.	lidocaine	myocardial infarction	3895875	-1
-During the 1-hour study period, the incidence of central nervous system side effects was significantly greater in the lidocaine group, hypotension occurred in 11 patients, nine of whom had received lidocaine, and four patients died from asystole, three of whom had had lidocaine. We cannot advocate the administration of lidocaine prophylactically in the early hours of suspected myocardial infarction.	lidocaine	asystole	3895875	-1
-During the 1-hour study period, the incidence of central nervous system side effects was significantly greater in the lidocaine group, hypotension occurred in 11 patients, nine of whom had received lidocaine, and four patients died from asystole, three of whom had had lidocaine. We cannot advocate the administration of lidocaine prophylactically in the early hours of suspected myocardial infarction.	lidocaine	hypotension	3895875	1
-During the 1-hour study period, the incidence of central nervous system side effects was significantly greater in the lidocaine group, hypotension occurred in 11 patients, nine of whom had received lidocaine, and four patients died from asystole, three of whom had had lidocaine. We cannot advocate the administration of lidocaine prophylactically in the early hours of suspected myocardial infarction.	lidocaine	myocardial infarction	3895875	-1
-During the 1-hour study period, the incidence of central nervous system side effects was significantly greater in the lidocaine group, hypotension occurred in 11 patients, nine of whom had received lidocaine, and four patients died from asystole, three of whom had had lidocaine. We cannot advocate the administration of lidocaine prophylactically in the early hours of suspected myocardial infarction.	lidocaine	asystole	3895875	-1
-During the 1-hour study period, the incidence of central nervous system side effects was significantly greater in the lidocaine group, hypotension occurred in 11 patients, nine of whom had received lidocaine, and four patients died from asystole, three of whom had had lidocaine. We cannot advocate the administration of lidocaine prophylactically in the early hours of suspected myocardial infarction.	lidocaine	hypotension	3895875	1
-During the 1-hour study period, the incidence of central nervous system side effects was significantly greater in the lidocaine group, hypotension occurred in 11 patients, nine of whom had received lidocaine, and four patients died from asystole, three of whom had had lidocaine. We cannot advocate the administration of lidocaine prophylactically in the early hours of suspected myocardial infarction.	lidocaine	myocardial infarction	3895875	-1
-During the 1-hour study period, the incidence of central nervous system side effects was significantly greater in the lidocaine group, hypotension occurred in 11 patients, nine of whom had received lidocaine, and four patients died from asystole, three of whom had had lidocaine. We cannot advocate the administration of lidocaine prophylactically in the early hours of suspected myocardial infarction.	lidocaine	asystole	3895875	-1
-During the 1-hour study period, the incidence of central nervous system side effects was significantly greater in the lidocaine group, hypotension occurred in 11 patients, nine of whom had received lidocaine, and four patients died from asystole, three of whom had had lidocaine. We cannot advocate the administration of lidocaine prophylactically in the early hours of suspected myocardial infarction.	lidocaine	hypotension	3895875	1
-During the 1-hour study period, the incidence of central nervous system side effects was significantly greater in the lidocaine group, hypotension occurred in 11 patients, nine of whom had received lidocaine, and four patients died from asystole, three of whom had had lidocaine. We cannot advocate the administration of lidocaine prophylactically in the early hours of suspected myocardial infarction.	lidocaine	myocardial infarction	3895875	-1
-During the 1-hour study period, the incidence of central nervous system side effects was significantly greater in the lidocaine group, hypotension occurred in 11 patients, nine of whom had received lidocaine, and four patients died from asystole, three of whom had had lidocaine. We cannot advocate the administration of lidocaine prophylactically in the early hours of suspected myocardial infarction.	lidocaine	asystole	3895875	-1
-The differential effects of bupivacaine and lidocaine on prostaglandin E2 release, cyclooxygenase gene expression and pain in a clinical pain model.	prostaglandin E2	pain	18165598	-1
-The differential effects of bupivacaine and lidocaine on prostaglandin E2 release, cyclooxygenase gene expression and pain in a clinical pain model.	prostaglandin E2	pain	18165598	-1
-The differential effects of bupivacaine and lidocaine on prostaglandin E2 release, cyclooxygenase gene expression and pain in a clinical pain model.	lidocaine	pain	18165598	-1
-The differential effects of bupivacaine and lidocaine on prostaglandin E2 release, cyclooxygenase gene expression and pain in a clinical pain model.	lidocaine	pain	18165598	-1
-The differential effects of bupivacaine and lidocaine on prostaglandin E2 release, cyclooxygenase gene expression and pain in a clinical pain model.	bupivacaine	pain	18165598	-1
-The differential effects of bupivacaine and lidocaine on prostaglandin E2 release, cyclooxygenase gene expression and pain in a clinical pain model.	bupivacaine	pain	18165598	-1
-The reduction in the levodopa dose is useful in controlling drug-induced dyskinesias.	levodopa	dyskinesias	12865514	1
-Acute renal insufficiency after high-dose melphalan in patients with primary systemic amyloidosis during stem cell transplantation.	melphalan	Acute renal insufficiency	15696449	1
-Acute renal insufficiency after high-dose melphalan in patients with primary systemic amyloidosis during stem cell transplantation.	melphalan	amyloidosis	15696449	-1
-Other ECG parameters before the application of d,l-sotalol did not identify patients at increased risk for torsades de pointes.	l-sotalol	torsades de pointes	9125676	1
-This article presents a patient with hypoparathyroidism who was treated with calcium carbonate and calcitriol resulting in two admissions to the hospital for milk-alkali syndrome.	calcitriol	hypoparathyroidism	8667442	-1
-This article presents a patient with hypoparathyroidism who was treated with calcium carbonate and calcitriol resulting in two admissions to the hospital for milk-alkali syndrome.	calcium carbonate	hypoparathyroidism	8667442	-1
-This article presents a patient with hypoparathyroidism who was treated with calcium carbonate and calcitriol resulting in two admissions to the hospital for milk-alkali syndrome.	calcium carbonate	milk-alkali syndrome	8667442	1
-The influence of L-dopa on the renal excretion of potassium was studied in 3 patients with hypokalemia and in 5 normokalemic patients by determination of renal plasma flow, glomerular filtration rate, plasma concentration of potassium and sodium as well as urinary excretion of potassium, sodium and aldosterone.	aldosterone	hypokalemia	851038	-1
-The influence of L-dopa on the renal excretion of potassium was studied in 3 patients with hypokalemia and in 5 normokalemic patients by determination of renal plasma flow, glomerular filtration rate, plasma concentration of potassium and sodium as well as urinary excretion of potassium, sodium and aldosterone.	sodium	hypokalemia	851038	-1
-The influence of L-dopa on the renal excretion of potassium was studied in 3 patients with hypokalemia and in 5 normokalemic patients by determination of renal plasma flow, glomerular filtration rate, plasma concentration of potassium and sodium as well as urinary excretion of potassium, sodium and aldosterone.	sodium	hypokalemia	851038	-1
-The influence of L-dopa on the renal excretion of potassium was studied in 3 patients with hypokalemia and in 5 normokalemic patients by determination of renal plasma flow, glomerular filtration rate, plasma concentration of potassium and sodium as well as urinary excretion of potassium, sodium and aldosterone.	potassium	hypokalemia	851038	-1
-The influence of L-dopa on the renal excretion of potassium was studied in 3 patients with hypokalemia and in 5 normokalemic patients by determination of renal plasma flow, glomerular filtration rate, plasma concentration of potassium and sodium as well as urinary excretion of potassium, sodium and aldosterone.	potassium	hypokalemia	851038	-1
-The influence of L-dopa on the renal excretion of potassium was studied in 3 patients with hypokalemia and in 5 normokalemic patients by determination of renal plasma flow, glomerular filtration rate, plasma concentration of potassium and sodium as well as urinary excretion of potassium, sodium and aldosterone.	potassium	hypokalemia	851038	-1
-The influence of L-dopa on the renal excretion of potassium was studied in 3 patients with hypokalemia and in 5 normokalemic patients by determination of renal plasma flow, glomerular filtration rate, plasma concentration of potassium and sodium as well as urinary excretion of potassium, sodium and aldosterone.	L-dopa	hypokalemia	851038	1
-Basal functioning of the hypothalamic-pituitary-adrenal (HPA) axis and psychological distress in recreational ecstasy polydrug users.	ecstasy	hypothalamic	24190587	-1
-Basal functioning of the hypothalamic-pituitary-adrenal (HPA) axis and psychological distress in recreational ecstasy polydrug users.	HPA	hypothalamic	24190587	-1
-Although this agent does decrease the frequency of rebleeding, several reports have described thrombotic complications of EACA therapy.	EACA	thrombotic	448423	1
-Five cases of paranoid exacerbation with the serotonin reuptake inhibitors fluoxetine and amitriptyline are reported here.	amitriptyline	paranoid	1837756	1
-Five cases of paranoid exacerbation with the serotonin reuptake inhibitors fluoxetine and amitriptyline are reported here.	fluoxetine	paranoid	1837756	1
-Five cases of paranoid exacerbation with the serotonin reuptake inhibitors fluoxetine and amitriptyline are reported here.	serotonin	paranoid	1837756	-1
-A case of fatal aplastic anemia due to carbamazepine treatment in an epileptic woman is reported.	carbamazepine	aplastic anemia	3409843	1
-A case of fatal aplastic anemia due to carbamazepine treatment in an epileptic woman is reported.	carbamazepine	epileptic	3409843	-1
-CONCLUSION: The data show that CCR2 and CCL2 are up-regulated in the hippocampus after pilocarpine-induced SE.	CCL2	SE	20034406	-1
-CONCLUSION: The data show that CCR2 and CCL2 are up-regulated in the hippocampus after pilocarpine-induced SE.	pilocarpine	SE	20034406	1
-The results indicate that GFC can exert anticonvulsant activity and reduce the frequency of installation of pilocarpine-induced status epilepticus, as demonstrated by increase in latency to first seizure and decrease in mortality rate of animals.	GFC	status epilepticus	24911645	-1
-The results indicate that GFC can exert anticonvulsant activity and reduce the frequency of installation of pilocarpine-induced status epilepticus, as demonstrated by increase in latency to first seizure and decrease in mortality rate of animals.	GFC	seizure	24911645	-1
-The results indicate that GFC can exert anticonvulsant activity and reduce the frequency of installation of pilocarpine-induced status epilepticus, as demonstrated by increase in latency to first seizure and decrease in mortality rate of animals.	pilocarpine	status epilepticus	24911645	1
-The authors have noted the development of acute renal insufficiency immediately after melphalan conditioning.	melphalan	acute renal insufficiency	15696449	1
-Single dose of DOX was associated with increased cardiac disarrangement, necrosis, and DNA damage (strand breaks (SBs) and oxidized pyrimidines) and decreased TAP.	DOX	necrosis	24275640	1
-Single dose of DOX was associated with increased cardiac disarrangement, necrosis, and DNA damage (strand breaks (SBs) and oxidized pyrimidines) and decreased TAP.	pyrimidines	necrosis	24275640	-1
-Nine months of hyperprolactinemia produced a 50% increase in DA concentrations in the ME over the control group.	DA	hyperprolactinemia	9128918	-1
-Acute renal failure occurring during intravenous desferrioxamine therapy: recovery after haemodialysis.	desferrioxamine	Acute renal failure	1289188	-1
-A patient with transfusion-dependent thalassemia was undergoing home intravenous desferrioxamine (DFX) treatment by means of a totally implanted system because of his poor compliance with the nightly subcutaneous therapy.	desferrioxamine	thalassemia	1289188	-1
-A patient with transfusion-dependent thalassemia was undergoing home intravenous desferrioxamine (DFX) treatment by means of a totally implanted system because of his poor compliance with the nightly subcutaneous therapy.	DFX	thalassemia	1289188	-1
-Acute renal insufficiency (ARI) after high-dose melphalan was defined by a minimum increase of 0.5 mg/dL (44 micromol/L) in the serum creatinine level that is greater than 50% of baseline immediately after conditioning.	creatinine	Acute renal insufficiency	15696449	-1
-Acute renal insufficiency (ARI) after high-dose melphalan was defined by a minimum increase of 0.5 mg/dL (44 micromol/L) in the serum creatinine level that is greater than 50% of baseline immediately after conditioning.	creatinine	ARI	15696449	-1
-Acute renal insufficiency (ARI) after high-dose melphalan was defined by a minimum increase of 0.5 mg/dL (44 micromol/L) in the serum creatinine level that is greater than 50% of baseline immediately after conditioning.	melphalan	ARI	15696449	1
-Only phenytoin sodium displayed in vitro antiarrhythmic activity against strophanthidin-induced arrhythmias in guinea pig right atria.	phenytoin sodium	arrhythmias	2767010	-1
-Risk of transient hyperammonemic encephalopathy in cancer patients who received continuous infusion of 5-fluorouracil with the complication of dehydration and infection.	5-fluorouracil	cancer	10327032	-1
-Risk of transient hyperammonemic encephalopathy in cancer patients who received continuous infusion of 5-fluorouracil with the complication of dehydration and infection.	5-fluorouracil	infection	10327032	-1
-Risk of transient hyperammonemic encephalopathy in cancer patients who received continuous infusion of 5-fluorouracil with the complication of dehydration and infection.	5-fluorouracil	dehydration	10327032	-1
-On the 49th day of terbinafine therapy, he was brought to the emergency room for a decrease of his global health status, confusion and falls.	terbinafine	confusion	24894748	-1
-From the results obtained, haemodialysis can therefore be suggested as a useful therapy in rare cases of progressive acute renal failure caused by desferrioxamine.	desferrioxamine	acute renal failure	1289188	-1
-Univariate analysis identified age, hypoalbuminemia, heavy proteinuria, diuretic use, and urine sediment score (>3) as risk factors.	diuretic	hypoalbuminemia	15696449	-1
-Univariate analysis identified age, hypoalbuminemia, heavy proteinuria, diuretic use, and urine sediment score (>3) as risk factors.	diuretic	proteinuria	15696449	-1
-Studies were performed to examine the mechanisms for the protective effects of free radical scavengers on gentamicin (GM)-mediated nephropathy.	GM)-mediated	nephropathy	8160791	1
-levodopa were examined in parkinsonian patients with stable and fluctuating responses to levodopa.	levodopa	parkinsonian	1423336	-1
-levodopa were examined in parkinsonian patients with stable and fluctuating responses to levodopa.	levodopa	parkinsonian	1423336	-1
-The total doses of ACC-9653 or phenytoin sodium necessary to convert the arrhythmia to a normal sinus rhythm were 24 +/-	ACC-9653	arrhythmia	2767010	-1
-The total doses of ACC-9653 or phenytoin sodium necessary to convert the arrhythmia to a normal sinus rhythm were 24 +/-	phenytoin sodium	arrhythmia	2767010	-1
-Increased secretion of vasopressin from neurohypophysis also promotes the function of the hormone as a pathogenetic factor in hypertension.	vasopressin	hypertension	6321816	-1
-Increased secretion of vasopressin from neurohypophysis also promotes the function of the hormone as a pathogenetic factor in hypertension.	vasopressin	neurohypophysis	6321816	-1
-The magnitude of the hypotensive effect of levodopa was concentration dependent and was fit to an Emax model in fluctuating responders.	levodopa	hypotensive	1423336	1
-Hypokalemia, sometimes severe, was observed in some L-dopa-treated parkinsonian patients.	L-dopa	parkinsonian	851038	-1
-: The timing of renal injury strongly suggests melphalan as the causative agent.	melphalan	renal injury	15696449	-1
-Testosterone ameliorates streptozotocin-induced memory impairment in male rats.	Testosterone	memory impairment	24902786	-1
-Testosterone ameliorates streptozotocin-induced memory impairment in male rats.	streptozotocin	memory impairment	24902786	1
-Prophylactic lidocaine in the early phase of suspected myocardial infarction.	lidocaine	myocardial infarction	3895875	-1
-STZ treatment showed decrease expression of post synaptic markers CaMKIIa and PSD-95, while, expression of pre synaptic markers (synaptophysin and SNAP-25) remains unaltered indicating selective post synaptic neurotoxicity.	STZ	synaptic neurotoxicity	24333387	-1
-STZ treatment showed decrease expression of post synaptic markers CaMKIIa and PSD-95, while, expression of pre synaptic markers (synaptophysin and SNAP-25) remains unaltered indicating selective post synaptic neurotoxicity.	synaptophysin	synaptic neurotoxicity	24333387	-1
-STZ treatment showed decrease expression of post synaptic markers CaMKIIa and PSD-95, while, expression of pre synaptic markers (synaptophysin and SNAP-25) remains unaltered indicating selective post synaptic neurotoxicity.	CaMKIIa	synaptic neurotoxicity	24333387	-1
-Antitumor activity, cardiotoxicity, and nephrotoxicity induced by doxorubicin were studied in LOU/M/WSL inbred rats each bearing a transplantable solid IgM immunocytoma.	doxorubicin	cardiotoxicity	6585590	-1
-Antitumor activity, cardiotoxicity, and nephrotoxicity induced by doxorubicin were studied in LOU/M/WSL inbred rats each bearing a transplantable solid IgM immunocytoma.	doxorubicin	IgM immunocytoma	6585590	-1
-Antitumor activity, cardiotoxicity, and nephrotoxicity induced by doxorubicin were studied in LOU/M/WSL inbred rats each bearing a transplantable solid IgM immunocytoma.	doxorubicin	nephrotoxicity	6585590	-1
-Phenylalanine, a large neutral amino acid (LNAA) competing with levodopa for transport across the blood-brain barrier, reduced the hypotensive and antiparkinsonian effects of levodopa.	Phenylalanine	hypotensive	1423336	-1
-Phenylalanine, a large neutral amino acid (LNAA) competing with levodopa for transport across the blood-brain barrier, reduced the hypotensive and antiparkinsonian effects of levodopa.	LNAA	hypotensive	1423336	-1
-Phenylalanine, a large neutral amino acid (LNAA) competing with levodopa for transport across the blood-brain barrier, reduced the hypotensive and antiparkinsonian effects of levodopa.	levodopa	hypotensive	1423336	1
-Phenylalanine, a large neutral amino acid (LNAA) competing with levodopa for transport across the blood-brain barrier, reduced the hypotensive and antiparkinsonian effects of levodopa.	amino acid	hypotensive	1423336	-1
-Therefore, when prescribing statins, the possibility of hepatic damage should be taken into account.	statins	hepatic damage	24451297	-1
-Here, we describe the case of a 15-year-old girl who was on a long-term therapy with valproate due to epilepsy and revealed impaired consciousness with hyperammonemia 12 days after renal transplantation.	valproate	impaired consciousness	24665854	1
-Here, we describe the case of a 15-year-old girl who was on a long-term therapy with valproate due to epilepsy and revealed impaired consciousness with hyperammonemia 12 days after renal transplantation.	valproate	hyperammonemia	24665854	1
-Here, we describe the case of a 15-year-old girl who was on a long-term therapy with valproate due to epilepsy and revealed impaired consciousness with hyperammonemia 12 days after renal transplantation.	valproate	epilepsy	24665854	-1
-The authors conclude by affirming the undoubted efficacy of the anabolizing steroids in experimental myopathic disease, but they have reservations as to the transfer of the results into the human field, where high dosage cannot be carried out continuously because of the effects of the drug on virility; because the tissue injury too often occurs at an irreversible stage vis-a-vis the "regeneration" of the muscle tissue; and finally because the dystrophic injurious agent is certainly not the lack of vitamin E but something as yet unknown.	vitamin E	myopathic disease	753803	-1
-The authors conclude by affirming the undoubted efficacy of the anabolizing steroids in experimental myopathic disease, but they have reservations as to the transfer of the results into the human field, where high dosage cannot be carried out continuously because of the effects of the drug on virility; because the tissue injury too often occurs at an irreversible stage vis-a-vis the "regeneration" of the muscle tissue; and finally because the dystrophic injurious agent is certainly not the lack of vitamin E but something as yet unknown.	steroids	myopathic disease	753803	-1
-We conclude that levodopa has a central hypotensive action that parallels the motor effects in fluctuating patients.	levodopa	hypotensive	1423336	1
-Hepatitis and renal tubular acidosis after anesthesia with methoxyflurane.	methoxyflurane	Hepatitis	6985498	1
-A retrospective, case-controlled analysis comparing patients admitted to a medical intensive care unit with severe exacerbations of asthma who received continuously nebulized albuterol (CNA) versus intermittent albuterol (INA) treatments is reported.	albuterol	asthma	9428298	-1
-A retrospective, case-controlled analysis comparing patients admitted to a medical intensive care unit with severe exacerbations of asthma who received continuously nebulized albuterol (CNA) versus intermittent albuterol (INA) treatments is reported.	albuterol	asthma	9428298	-1
-The coronary vasodilating properties of nisoldipine have led to the investigation of this agent for use in angina.	nisoldipine	angina	3323259	-1
-Participation of a bulbospinal serotonergic pathway in the rat brain in clonidine-induced hypotension and bradycardia.	clonidine	hypotension	3423103	1
-Participation of a bulbospinal serotonergic pathway in the rat brain in clonidine-induced hypotension and bradycardia.	clonidine	bradycardia	3423103	1
-At these high doses of CYA, serious cardiotoxicity may occur, but definitive risk factors for the development of such cardiotoxicity have not been described.	CYA	cardiotoxicity	3533179	-1
-At these high doses of CYA, serious cardiotoxicity may occur, but definitive risk factors for the development of such cardiotoxicity have not been described.	CYA	cardiotoxicity	3533179	-1
-We therefore examined whether bupivacaine alters the dysrhythmogenicity of subsequent administration of epinephrine in conscious, healthy dogs and in anesthetized dogs with myocardial infarction.	epinephrine	myocardial infarction	8659767	-1
-We therefore examined whether bupivacaine alters the dysrhythmogenicity of subsequent administration of epinephrine in conscious, healthy dogs and in anesthetized dogs with myocardial infarction.	bupivacaine	myocardial infarction	8659767	-1
-This retrospective study describes toxicity associated with a protocol of lomustine (CCNU) and cyclophosphamide (CTX) in dogs with lymphoma.	cyclophosphamide	toxicity	24659727	-1
-This retrospective study describes toxicity associated with a protocol of lomustine (CCNU) and cyclophosphamide (CTX) in dogs with lymphoma.	cyclophosphamide	lymphoma	24659727	-1
-This retrospective study describes toxicity associated with a protocol of lomustine (CCNU) and cyclophosphamide (CTX) in dogs with lymphoma.	lomustine	toxicity	24659727	-1
-This retrospective study describes toxicity associated with a protocol of lomustine (CCNU) and cyclophosphamide (CTX) in dogs with lymphoma.	lomustine	lymphoma	24659727	-1
-This retrospective study describes toxicity associated with a protocol of lomustine (CCNU) and cyclophosphamide (CTX) in dogs with lymphoma.	CCNU	toxicity	24659727	-1
-This retrospective study describes toxicity associated with a protocol of lomustine (CCNU) and cyclophosphamide (CTX) in dogs with lymphoma.	CCNU	lymphoma	24659727	-1
-This retrospective study describes toxicity associated with a protocol of lomustine (CCNU) and cyclophosphamide (CTX) in dogs with lymphoma.	CTX	toxicity	24659727	-1
-This retrospective study describes toxicity associated with a protocol of lomustine (CCNU) and cyclophosphamide (CTX) in dogs with lymphoma.	CTX	lymphoma	24659727	-1
-BACKGROUND: Succinylcholine commonly produces frequent adverse effects, including muscle fasciculation and myalgia.	Succinylcholine	muscle fasciculation	25006369	1
-BACKGROUND: The aim of the study was to investigate the antihypertensive effects of angiotensin II type-1 receptor blocker, losartan, and its potential in slowing down renal disease progression in spontaneously hypertensive rats (SHR) with adriamycin (ADR) nephropathy.	adriamycin	hypertensive	18987260	-1
-BACKGROUND: The aim of the study was to investigate the antihypertensive effects of angiotensin II type-1 receptor blocker, losartan, and its potential in slowing down renal disease progression in spontaneously hypertensive rats (SHR) with adriamycin (ADR) nephropathy.	adriamycin	renal disease	18987260	-1
-BACKGROUND: The aim of the study was to investigate the antihypertensive effects of angiotensin II type-1 receptor blocker, losartan, and its potential in slowing down renal disease progression in spontaneously hypertensive rats (SHR) with adriamycin (ADR) nephropathy.	adriamycin	nephropathy	18987260	-1
-BACKGROUND: The aim of the study was to investigate the antihypertensive effects of angiotensin II type-1 receptor blocker, losartan, and its potential in slowing down renal disease progression in spontaneously hypertensive rats (SHR) with adriamycin (ADR) nephropathy.	ADR	hypertensive	18987260	-1
-BACKGROUND: The aim of the study was to investigate the antihypertensive effects of angiotensin II type-1 receptor blocker, losartan, and its potential in slowing down renal disease progression in spontaneously hypertensive rats (SHR) with adriamycin (ADR) nephropathy.	ADR	renal disease	18987260	-1
-BACKGROUND: The aim of the study was to investigate the antihypertensive effects of angiotensin II type-1 receptor blocker, losartan, and its potential in slowing down renal disease progression in spontaneously hypertensive rats (SHR) with adriamycin (ADR) nephropathy.	ADR	nephropathy	18987260	-1
-BACKGROUND: The aim of the study was to investigate the antihypertensive effects of angiotensin II type-1 receptor blocker, losartan, and its potential in slowing down renal disease progression in spontaneously hypertensive rats (SHR) with adriamycin (ADR) nephropathy.	losartan	hypertensive	18987260	-1
-BACKGROUND: The aim of the study was to investigate the antihypertensive effects of angiotensin II type-1 receptor blocker, losartan, and its potential in slowing down renal disease progression in spontaneously hypertensive rats (SHR) with adriamycin (ADR) nephropathy.	losartan	renal disease	18987260	-1
-BACKGROUND: The aim of the study was to investigate the antihypertensive effects of angiotensin II type-1 receptor blocker, losartan, and its potential in slowing down renal disease progression in spontaneously hypertensive rats (SHR) with adriamycin (ADR) nephropathy.	losartan	nephropathy	18987260	-1
-BACKGROUND: The aim of the study was to investigate the antihypertensive effects of angiotensin II type-1 receptor blocker, losartan, and its potential in slowing down renal disease progression in spontaneously hypertensive rats (SHR) with adriamycin (ADR) nephropathy.	angiotensin II	hypertensive	18987260	-1
-BACKGROUND: The aim of the study was to investigate the antihypertensive effects of angiotensin II type-1 receptor blocker, losartan, and its potential in slowing down renal disease progression in spontaneously hypertensive rats (SHR) with adriamycin (ADR) nephropathy.	angiotensin II	renal disease	18987260	-1
-BACKGROUND: The aim of the study was to investigate the antihypertensive effects of angiotensin II type-1 receptor blocker, losartan, and its potential in slowing down renal disease progression in spontaneously hypertensive rats (SHR) with adriamycin (ADR) nephropathy.	angiotensin II	nephropathy	18987260	-1
-The current study identified the optimal dose of rocuronium to prevent succinylcholine-induced fasciculation and myalgia and evaluated the influence of rocuronium on the speed of onset produced by succinylcholine.	succinylcholine	fasciculation	25006369	1
-The current study identified the optimal dose of rocuronium to prevent succinylcholine-induced fasciculation and myalgia and evaluated the influence of rocuronium on the speed of onset produced by succinylcholine.	succinylcholine	myalgia	25006369	1
-The current study identified the optimal dose of rocuronium to prevent succinylcholine-induced fasciculation and myalgia and evaluated the influence of rocuronium on the speed of onset produced by succinylcholine.	succinylcholine	fasciculation	25006369	1
-The current study identified the optimal dose of rocuronium to prevent succinylcholine-induced fasciculation and myalgia and evaluated the influence of rocuronium on the speed of onset produced by succinylcholine.	succinylcholine	myalgia	25006369	1
-The current study identified the optimal dose of rocuronium to prevent succinylcholine-induced fasciculation and myalgia and evaluated the influence of rocuronium on the speed of onset produced by succinylcholine.	rocuronium	fasciculation	25006369	-1
-The current study identified the optimal dose of rocuronium to prevent succinylcholine-induced fasciculation and myalgia and evaluated the influence of rocuronium on the speed of onset produced by succinylcholine.	rocuronium	myalgia	25006369	-1
-The current study identified the optimal dose of rocuronium to prevent succinylcholine-induced fasciculation and myalgia and evaluated the influence of rocuronium on the speed of onset produced by succinylcholine.	rocuronium	fasciculation	25006369	-1
-The current study identified the optimal dose of rocuronium to prevent succinylcholine-induced fasciculation and myalgia and evaluated the influence of rocuronium on the speed of onset produced by succinylcholine.	rocuronium	myalgia	25006369	-1
-Once or twice daily dosage possible with nitrendipine and nisoldipine offers a convenient administration schedule, which encourages patient compliance in long-term therapy of hypertension.	nisoldipine	hypertension	3323259	-1
-Once or twice daily dosage possible with nitrendipine and nisoldipine offers a convenient administration schedule, which encourages patient compliance in long-term therapy of hypertension.	nitrendipine	hypertension	3323259	-1
-Emerging evidence indicates that voltage-dependent Na(+) channels have pivotal roles in the cardiotoxicity of aconitine.	Na(+	cardiotoxicity	24840785	-1
-Dexamethasone- (Dex-) induced hypertension is associated with enhanced oxidative stress.	Dexamethasone-	hypertension	24587916	1
-Dexamethasone- (Dex-) induced hypertension is associated with enhanced oxidative stress.	Dex-	hypertension	24587916	1
-In order to evaluate the efficacy, time-course of action and predictors of response to topical capsaicin, 39 patients with chronic post-herpetic neuralgia (PHN), median duration 24 months, were treated with 0.025% capsaicin cream for 8 weeks.	capsaicin	neuralgia	1779253	-1
-In order to evaluate the efficacy, time-course of action and predictors of response to topical capsaicin, 39 patients with chronic post-herpetic neuralgia (PHN), median duration 24 months, were treated with 0.025% capsaicin cream for 8 weeks.	capsaicin cream	neuralgia	1779253	-1
-There were no infectious deaths in renal transplant patients on cyclosporine or Aza, but infection played a major role in 3 out of 6 cardiac transplant deaths and in 8 out of 9 liver transplant deaths.	cyclosporine	infection	6310832	1
-There were no infectious deaths in renal transplant patients on cyclosporine or Aza, but infection played a major role in 3 out of 6 cardiac transplant deaths and in 8 out of 9 liver transplant deaths.	cyclosporine	infectious deaths	6310832	-1
-There were no infectious deaths in renal transplant patients on cyclosporine or Aza, but infection played a major role in 3 out of 6 cardiac transplant deaths and in 8 out of 9 liver transplant deaths.	cyclosporine	deaths	6310832	-1
-There were no infectious deaths in renal transplant patients on cyclosporine or Aza, but infection played a major role in 3 out of 6 cardiac transplant deaths and in 8 out of 9 liver transplant deaths.	cyclosporine	deaths	6310832	-1
-There were no infectious deaths in renal transplant patients on cyclosporine or Aza, but infection played a major role in 3 out of 6 cardiac transplant deaths and in 8 out of 9 liver transplant deaths.	Aza	infectious deaths	6310832	-1
-There were no infectious deaths in renal transplant patients on cyclosporine or Aza, but infection played a major role in 3 out of 6 cardiac transplant deaths and in 8 out of 9 liver transplant deaths.	Aza	deaths	6310832	-1
-There were no infectious deaths in renal transplant patients on cyclosporine or Aza, but infection played a major role in 3 out of 6 cardiac transplant deaths and in 8 out of 9 liver transplant deaths.	Aza	deaths	6310832	-1
-Necrotising fasciitis after bortezomib and dexamethasone-containing regimen in an elderly patient of Waldenstrom macroglobulinaemia.	bortezomib	Waldenstrom macroglobulinaemia	24671324	-1
-Necrotising fasciitis after bortezomib and dexamethasone-containing regimen in an elderly patient of Waldenstrom macroglobulinaemia.	bortezomib	Necrotising fasciitis	24671324	-1
-Necrotising fasciitis after bortezomib and dexamethasone-containing regimen in an elderly patient of Waldenstrom macroglobulinaemia.	dexamethasone	Waldenstrom macroglobulinaemia	24671324	-1
-Necrotising fasciitis after bortezomib and dexamethasone-containing regimen in an elderly patient of Waldenstrom macroglobulinaemia.	dexamethasone	Necrotising fasciitis	24671324	-1
-BACKGROUND: Animals treated with gentamicin can show residual areas of interstitial fibrosis in the renal cortex.	gentamicin	interstitial fibrosis	15627798	-1
-analysis of the effects of other inotropic drugs shows an excess mortality and there is a possibility that digoxin may increase mortality after myocardial infarction (MI).	digoxin	myocardial infarction	1449452	-1
-analysis of the effects of other inotropic drugs shows an excess mortality and there is a possibility that digoxin may increase mortality after myocardial infarction (MI).	digoxin	MI	1449452	-1
-Bilateral intrastriatal injections of isoniazid did not augment seizures produced by pilocarpine, 200 mg/kg.	isoniazid	seizures	3708328	-1
-PURPOSE: To report the treatment outcomes of the fluocinolone acetonide intravitreal implant (0.59 mg) in patients with birdshot retinochoroidopathy whose disease is refractory or intolerant to conventional immunomodulatory therapy.	fluocinolone acetonide	birdshot retinochoroidopathy whose disease	24999722	-1
-Increased frequency and severity of angio-oedema related to long-term therapy with angiotensin-converting enzyme inhibitor in two patients.	angiotensin	angio-oedema	7671401	-1
-Our data show that ablation of PKCa preserves AQP2 and UT-A1 protein expression and localization in lithium-induced NDI, and prevents the development of the severe polyuria associated with lithium therapy.	lithium	polyuria	25006961	1
-Our data show that ablation of PKCa preserves AQP2 and UT-A1 protein expression and localization in lithium-induced NDI, and prevents the development of the severe polyuria associated with lithium therapy.	lithium	NDI	25006961	1
-Our data show that ablation of PKCa preserves AQP2 and UT-A1 protein expression and localization in lithium-induced NDI, and prevents the development of the severe polyuria associated with lithium therapy.	lithium	polyuria	25006961	1
-Kinin B2 receptor deletion and blockage ameliorates cisplatin-induced acute renal injury. Cisplatin treatment has been adopted in some chemotherapies; however, this drug can induce acute kidney injury due its ability to negatively affect renal function, augment serum levels of creatinine and urea, increase the acute tubular necrosis score and up-regulate cytokines (e.g., IL-1b and TNF-a).	creatinine	acute renal injury	24975837	-1
-Kinin B2 receptor deletion and blockage ameliorates cisplatin-induced acute renal injury. Cisplatin treatment has been adopted in some chemotherapies; however, this drug can induce acute kidney injury due its ability to negatively affect renal function, augment serum levels of creatinine and urea, increase the acute tubular necrosis score and up-regulate cytokines (e.g., IL-1b and TNF-a).	creatinine	acute kidney injury	24975837	-1
-Kinin B2 receptor deletion and blockage ameliorates cisplatin-induced acute renal injury. Cisplatin treatment has been adopted in some chemotherapies; however, this drug can induce acute kidney injury due its ability to negatively affect renal function, augment serum levels of creatinine and urea, increase the acute tubular necrosis score and up-regulate cytokines (e.g., IL-1b and TNF-a).	creatinine	increase the acute tubular necrosis	24975837	-1
-Kinin B2 receptor deletion and blockage ameliorates cisplatin-induced acute renal injury. Cisplatin treatment has been adopted in some chemotherapies; however, this drug can induce acute kidney injury due its ability to negatively affect renal function, augment serum levels of creatinine and urea, increase the acute tubular necrosis score and up-regulate cytokines (e.g., IL-1b and TNF-a).	urea	acute renal injury	24975837	-1
-Kinin B2 receptor deletion and blockage ameliorates cisplatin-induced acute renal injury. Cisplatin treatment has been adopted in some chemotherapies; however, this drug can induce acute kidney injury due its ability to negatively affect renal function, augment serum levels of creatinine and urea, increase the acute tubular necrosis score and up-regulate cytokines (e.g., IL-1b and TNF-a).	urea	acute kidney injury	24975837	-1
-Kinin B2 receptor deletion and blockage ameliorates cisplatin-induced acute renal injury. Cisplatin treatment has been adopted in some chemotherapies; however, this drug can induce acute kidney injury due its ability to negatively affect renal function, augment serum levels of creatinine and urea, increase the acute tubular necrosis score and up-regulate cytokines (e.g., IL-1b and TNF-a).	urea	increase the acute tubular necrosis	24975837	-1
-Kinin B2 receptor deletion and blockage ameliorates cisplatin-induced acute renal injury. Cisplatin treatment has been adopted in some chemotherapies; however, this drug can induce acute kidney injury due its ability to negatively affect renal function, augment serum levels of creatinine and urea, increase the acute tubular necrosis score and up-regulate cytokines (e.g., IL-1b and TNF-a).	cisplatin	acute renal injury	24975837	1
-Kinin B2 receptor deletion and blockage ameliorates cisplatin-induced acute renal injury. Cisplatin treatment has been adopted in some chemotherapies; however, this drug can induce acute kidney injury due its ability to negatively affect renal function, augment serum levels of creatinine and urea, increase the acute tubular necrosis score and up-regulate cytokines (e.g., IL-1b and TNF-a).	cisplatin	acute kidney injury	24975837	1
-Kinin B2 receptor deletion and blockage ameliorates cisplatin-induced acute renal injury. Cisplatin treatment has been adopted in some chemotherapies; however, this drug can induce acute kidney injury due its ability to negatively affect renal function, augment serum levels of creatinine and urea, increase the acute tubular necrosis score and up-regulate cytokines (e.g., IL-1b and TNF-a).	cisplatin	increase the acute tubular necrosis	24975837	1
-Kinin B2 receptor deletion and blockage ameliorates cisplatin-induced acute renal injury. Cisplatin treatment has been adopted in some chemotherapies; however, this drug can induce acute kidney injury due its ability to negatively affect renal function, augment serum levels of creatinine and urea, increase the acute tubular necrosis score and up-regulate cytokines (e.g., IL-1b and TNF-a).	Cisplatin	acute renal injury	24975837	1
-Kinin B2 receptor deletion and blockage ameliorates cisplatin-induced acute renal injury. Cisplatin treatment has been adopted in some chemotherapies; however, this drug can induce acute kidney injury due its ability to negatively affect renal function, augment serum levels of creatinine and urea, increase the acute tubular necrosis score and up-regulate cytokines (e.g., IL-1b and TNF-a).	Cisplatin	acute kidney injury	24975837	1
-METHODS AND MATERIALS: Patients with ovarian or fallopian tube cancers or primary peritoneal carcinoma with platinum/paclitaxel-refractory disease (stable or progressive disease following treatment with these agents or previous objective response <3 months in duration) were treated with liposomal doxorubicin at a dose of 40 mg/m(2) q 4 weeks.	doxorubicin	fallopian tube cancers	10985896	-1
-METHODS AND MATERIALS: Patients with ovarian or fallopian tube cancers or primary peritoneal carcinoma with platinum/paclitaxel-refractory disease (stable or progressive disease following treatment with these agents or previous objective response <3 months in duration) were treated with liposomal doxorubicin at a dose of 40 mg/m(2) q 4 weeks.	doxorubicin	carcinoma	10985896	-1
-METHODS AND MATERIALS: Patients with ovarian or fallopian tube cancers or primary peritoneal carcinoma with platinum/paclitaxel-refractory disease (stable or progressive disease following treatment with these agents or previous objective response <3 months in duration) were treated with liposomal doxorubicin at a dose of 40 mg/m(2) q 4 weeks.	doxorubicin	ovarian	10985896	-1
-METHODS AND MATERIALS: Patients with ovarian or fallopian tube cancers or primary peritoneal carcinoma with platinum/paclitaxel-refractory disease (stable or progressive disease following treatment with these agents or previous objective response <3 months in duration) were treated with liposomal doxorubicin at a dose of 40 mg/m(2) q 4 weeks.	paclitaxel	fallopian tube cancers	10985896	-1
-METHODS AND MATERIALS: Patients with ovarian or fallopian tube cancers or primary peritoneal carcinoma with platinum/paclitaxel-refractory disease (stable or progressive disease following treatment with these agents or previous objective response <3 months in duration) were treated with liposomal doxorubicin at a dose of 40 mg/m(2) q 4 weeks.	paclitaxel	carcinoma	10985896	-1
-METHODS AND MATERIALS: Patients with ovarian or fallopian tube cancers or primary peritoneal carcinoma with platinum/paclitaxel-refractory disease (stable or progressive disease following treatment with these agents or previous objective response <3 months in duration) were treated with liposomal doxorubicin at a dose of 40 mg/m(2) q 4 weeks.	paclitaxel	ovarian	10985896	-1
-METHODS AND MATERIALS: Patients with ovarian or fallopian tube cancers or primary peritoneal carcinoma with platinum/paclitaxel-refractory disease (stable or progressive disease following treatment with these agents or previous objective response <3 months in duration) were treated with liposomal doxorubicin at a dose of 40 mg/m(2) q 4 weeks.	platinum	fallopian tube cancers	10985896	-1
-METHODS AND MATERIALS: Patients with ovarian or fallopian tube cancers or primary peritoneal carcinoma with platinum/paclitaxel-refractory disease (stable or progressive disease following treatment with these agents or previous objective response <3 months in duration) were treated with liposomal doxorubicin at a dose of 40 mg/m(2) q 4 weeks.	platinum	carcinoma	10985896	-1
-METHODS AND MATERIALS: Patients with ovarian or fallopian tube cancers or primary peritoneal carcinoma with platinum/paclitaxel-refractory disease (stable or progressive disease following treatment with these agents or previous objective response <3 months in duration) were treated with liposomal doxorubicin at a dose of 40 mg/m(2) q 4 weeks.	platinum	ovarian	10985896	-1
-The cumulative bupivacaine dose given at those time points was higher in Group P. Plasma bupivacaine levels were significantly lower in Group P than in Group C. Bupivacaine levels in the brain and heart were significantly lower in Group P and Group L than in Group C. CONCLUSION: We conclude that pre-treatment with propofol in intralipid, compared with propofol in medialipid or saline, delayed the onset of bupivacaine-induced cardiotoxic effects as well as reduced plasma bupivacaine levels.	propofol	cardiotoxic	24438483	-1
-The cumulative bupivacaine dose given at those time points was higher in Group P. Plasma bupivacaine levels were significantly lower in Group P than in Group C. Bupivacaine levels in the brain and heart were significantly lower in Group P and Group L than in Group C. CONCLUSION: We conclude that pre-treatment with propofol in intralipid, compared with propofol in medialipid or saline, delayed the onset of bupivacaine-induced cardiotoxic effects as well as reduced plasma bupivacaine levels.	propofol	cardiotoxic	24438483	-1
-The cumulative bupivacaine dose given at those time points was higher in Group P. Plasma bupivacaine levels were significantly lower in Group P than in Group C. Bupivacaine levels in the brain and heart were significantly lower in Group P and Group L than in Group C. CONCLUSION: We conclude that pre-treatment with propofol in intralipid, compared with propofol in medialipid or saline, delayed the onset of bupivacaine-induced cardiotoxic effects as well as reduced plasma bupivacaine levels.	bupivacaine	cardiotoxic	24438483	1
-The cumulative bupivacaine dose given at those time points was higher in Group P. Plasma bupivacaine levels were significantly lower in Group P than in Group C. Bupivacaine levels in the brain and heart were significantly lower in Group P and Group L than in Group C. CONCLUSION: We conclude that pre-treatment with propofol in intralipid, compared with propofol in medialipid or saline, delayed the onset of bupivacaine-induced cardiotoxic effects as well as reduced plasma bupivacaine levels.	bupivacaine	cardiotoxic	24438483	1
-Protocols of conversion from cyclosporin A (CsA) to sirolimus (SRL) have been widely used in immunotherapy after transplantation to prevent CsA-induced nephropathy, but the molecular mechanisms underlying these protocols remain nuclear.	sirolimus	nephropathy	24971338	-1
-Protocols of conversion from cyclosporin A (CsA) to sirolimus (SRL) have been widely used in immunotherapy after transplantation to prevent CsA-induced nephropathy, but the molecular mechanisms underlying these protocols remain nuclear.	SRL	nephropathy	24971338	-1
-Protocols of conversion from cyclosporin A (CsA) to sirolimus (SRL) have been widely used in immunotherapy after transplantation to prevent CsA-induced nephropathy, but the molecular mechanisms underlying these protocols remain nuclear.	cyclosporin A	nephropathy	24971338	1
-Protocols of conversion from cyclosporin A (CsA) to sirolimus (SRL) have been widely used in immunotherapy after transplantation to prevent CsA-induced nephropathy, but the molecular mechanisms underlying these protocols remain nuclear.	CsA	nephropathy	24971338	1
-Posttransplant anemia: the role of sirolimus.	sirolimus	anemia	19553912	1
-The feasibility of using labetalol, an alpha- and beta-adrenergic blocking agent, as a hypotensive agent in combination with inhalation anaesthetics (halothane, enflurane or isoflurane) was studied in 23 adult patients undergoing middle-ear surgery.	halothane	hypotensive	2718706	1
-The feasibility of using labetalol, an alpha- and beta-adrenergic blocking agent, as a hypotensive agent in combination with inhalation anaesthetics (halothane, enflurane or isoflurane) was studied in 23 adult patients undergoing middle-ear surgery.	enflurane	hypotensive	2718706	1
-The feasibility of using labetalol, an alpha- and beta-adrenergic blocking agent, as a hypotensive agent in combination with inhalation anaesthetics (halothane, enflurane or isoflurane) was studied in 23 adult patients undergoing middle-ear surgery.	labetalol	hypotensive	2718706	1
-L-Dopa intake was found to cause an increased excretion of potassium, and sometimes also of sodium, in the hypokalemic but not in the normokalemic patients.	sodium	hypokalemic	851038	-1
-L-Dopa intake was found to cause an increased excretion of potassium, and sometimes also of sodium, in the hypokalemic but not in the normokalemic patients.	potassium	hypokalemic	851038	-1
-L-Dopa intake was found to cause an increased excretion of potassium, and sometimes also of sodium, in the hypokalemic but not in the normokalemic patients.	L-Dopa	hypokalemic	851038	-1
-Effect of methoxamine on maximum urethral pressure in women with genuine stress incontinence: a placebo-controlled, double-blind crossover study.	methoxamine	stress incontinence	11135381	-1
-Hepatocellular carcinoma in Fanconi's anemia treated with androgen and corticosteroid.	corticosteroid	Fanconi's anemia	1655018	-1
-Hepatocellular carcinoma in Fanconi's anemia treated with androgen and corticosteroid.	corticosteroid	Hepatocellular carcinoma	1655018	1
-This depressive-like profile induced by METH was accompanied by a marked depletion of frontostriatal dopaminergic and serotonergic neurotransmission, indicated by a reduction in the levels of dopamine, DOPAC and HVA, tyrosine hydroxylase and serotonin, observed at both 3 and 49 days post-administration.	serotonin	depressive	24072398	-1
-This depressive-like profile induced by METH was accompanied by a marked depletion of frontostriatal dopaminergic and serotonergic neurotransmission, indicated by a reduction in the levels of dopamine, DOPAC and HVA, tyrosine hydroxylase and serotonin, observed at both 3 and 49 days post-administration.	dopamine	depressive	24072398	-1
-This depressive-like profile induced by METH was accompanied by a marked depletion of frontostriatal dopaminergic and serotonergic neurotransmission, indicated by a reduction in the levels of dopamine, DOPAC and HVA, tyrosine hydroxylase and serotonin, observed at both 3 and 49 days post-administration.	DOPAC	depressive	24072398	-1
-This depressive-like profile induced by METH was accompanied by a marked depletion of frontostriatal dopaminergic and serotonergic neurotransmission, indicated by a reduction in the levels of dopamine, DOPAC and HVA, tyrosine hydroxylase and serotonin, observed at both 3 and 49 days post-administration.	METH	depressive	24072398	1
-To our knowledge, this is the first report of nicergoline-associated AIN.	nicergoline	AIN	12372954	-1
-Oxidative stress on cardiotoxicity after treatment with single and multiple doses of doxorubicin.	doxorubicin	cardiotoxicity	24275640	1
-A 69-yr-old man, who was concurrently being treated with pilocarpine nitrate and timolol maleate eye drops, developed a bradycardia and became hypotensive during halothane anaesthesia.	halothane	hypotensive	6615679	-1
-A 69-yr-old man, who was concurrently being treated with pilocarpine nitrate and timolol maleate eye drops, developed a bradycardia and became hypotensive during halothane anaesthesia.	halothane	bradycardia	6615679	-1
-A 69-yr-old man, who was concurrently being treated with pilocarpine nitrate and timolol maleate eye drops, developed a bradycardia and became hypotensive during halothane anaesthesia.	timolol	hypotensive	6615679	1
-A 69-yr-old man, who was concurrently being treated with pilocarpine nitrate and timolol maleate eye drops, developed a bradycardia and became hypotensive during halothane anaesthesia.	pilocarpine nitrate	bradycardia	6615679	1
-Rifampicin was administered thrice as one of the 3-4 drug regimen and each time he developed untoward side effects like nausea, vomiting and fever with chills and rigors.	Rifampicin	nausea	2083961	-1
-Rifampicin was administered thrice as one of the 3-4 drug regimen and each time he developed untoward side effects like nausea, vomiting and fever with chills and rigors.	Rifampicin	fever	2083961	-1
-Rifampicin was administered thrice as one of the 3-4 drug regimen and each time he developed untoward side effects like nausea, vomiting and fever with chills and rigors.	Rifampicin	vomiting	2083961	-1
-As the first dihydropyridine available for use in the United States, nifedipine controls angina and hypertension with minimal depression of cardiac function.	dihydropyridine	hypertension	3323259	-1
-As the first dihydropyridine available for use in the United States, nifedipine controls angina and hypertension with minimal depression of cardiac function.	dihydropyridine	angina	3323259	-1
-As the first dihydropyridine available for use in the United States, nifedipine controls angina and hypertension with minimal depression of cardiac function.	dihydropyridine	depression	3323259	-1
-As the first dihydropyridine available for use in the United States, nifedipine controls angina and hypertension with minimal depression of cardiac function.	nifedipine	hypertension	3323259	-1
-As the first dihydropyridine available for use in the United States, nifedipine controls angina and hypertension with minimal depression of cardiac function.	nifedipine	angina	3323259	-1
-As the first dihydropyridine available for use in the United States, nifedipine controls angina and hypertension with minimal depression of cardiac function.	nifedipine	depression	3323259	-1
-BACKGROUND: The optimal dosing regimens of lipid emulsion, epinephrine, or both are not yet determined in neonates in cases of local anaesthetic systemic toxicity (LAST). METHODS: Newborn piglets received levobupivacaine until cardiovascular collapse occurred.	levobupivacaine	toxicity	24091473	-1
-BACKGROUND: The optimal dosing regimens of lipid emulsion, epinephrine, or both are not yet determined in neonates in cases of local anaesthetic systemic toxicity (LAST). METHODS: Newborn piglets received levobupivacaine until cardiovascular collapse occurred.	epinephrine	toxicity	24091473	-1
-However, additional important untoward effects of heparin therapy include heparin-induced thrombocytopenia, heparin-associated osteoporosis, eosinophilia, skin reactions, allergic reactions other than thrombocytopenia, alopecia, transaminasemia, hyperkalemia, hypoaldosteronism, and priapism.	heparin	hyperkalemia	10726030	1
-However, additional important untoward effects of heparin therapy include heparin-induced thrombocytopenia, heparin-associated osteoporosis, eosinophilia, skin reactions, allergic reactions other than thrombocytopenia, alopecia, transaminasemia, hyperkalemia, hypoaldosteronism, and priapism.	heparin	hypoaldosteronism	10726030	1
-However, additional important untoward effects of heparin therapy include heparin-induced thrombocytopenia, heparin-associated osteoporosis, eosinophilia, skin reactions, allergic reactions other than thrombocytopenia, alopecia, transaminasemia, hyperkalemia, hypoaldosteronism, and priapism.	heparin	thrombocytopenia	10726030	1
-However, additional important untoward effects of heparin therapy include heparin-induced thrombocytopenia, heparin-associated osteoporosis, eosinophilia, skin reactions, allergic reactions other than thrombocytopenia, alopecia, transaminasemia, hyperkalemia, hypoaldosteronism, and priapism.	heparin	alopecia	10726030	1
-However, additional important untoward effects of heparin therapy include heparin-induced thrombocytopenia, heparin-associated osteoporosis, eosinophilia, skin reactions, allergic reactions other than thrombocytopenia, alopecia, transaminasemia, hyperkalemia, hypoaldosteronism, and priapism.	heparin	osteoporosis	10726030	1
-However, additional important untoward effects of heparin therapy include heparin-induced thrombocytopenia, heparin-associated osteoporosis, eosinophilia, skin reactions, allergic reactions other than thrombocytopenia, alopecia, transaminasemia, hyperkalemia, hypoaldosteronism, and priapism.	heparin	priapism	10726030	1
-However, additional important untoward effects of heparin therapy include heparin-induced thrombocytopenia, heparin-associated osteoporosis, eosinophilia, skin reactions, allergic reactions other than thrombocytopenia, alopecia, transaminasemia, hyperkalemia, hypoaldosteronism, and priapism.	heparin	hypoaldosteronism	10726030	1
-However, additional important untoward effects of heparin therapy include heparin-induced thrombocytopenia, heparin-associated osteoporosis, eosinophilia, skin reactions, allergic reactions other than thrombocytopenia, alopecia, transaminasemia, hyperkalemia, hypoaldosteronism, and priapism.	heparin	thrombocytopenia	10726030	1
-However, additional important untoward effects of heparin therapy include heparin-induced thrombocytopenia, heparin-associated osteoporosis, eosinophilia, skin reactions, allergic reactions other than thrombocytopenia, alopecia, transaminasemia, hyperkalemia, hypoaldosteronism, and priapism.	heparin	thrombocytopenia	10726030	1
-However, additional important untoward effects of heparin therapy include heparin-induced thrombocytopenia, heparin-associated osteoporosis, eosinophilia, skin reactions, allergic reactions other than thrombocytopenia, alopecia, transaminasemia, hyperkalemia, hypoaldosteronism, and priapism.	heparin	osteoporosis	10726030	1
-However, additional important untoward effects of heparin therapy include heparin-induced thrombocytopenia, heparin-associated osteoporosis, eosinophilia, skin reactions, allergic reactions other than thrombocytopenia, alopecia, transaminasemia, hyperkalemia, hypoaldosteronism, and priapism.	heparin	priapism	10726030	1
-However, additional important untoward effects of heparin therapy include heparin-induced thrombocytopenia, heparin-associated osteoporosis, eosinophilia, skin reactions, allergic reactions other than thrombocytopenia, alopecia, transaminasemia, hyperkalemia, hypoaldosteronism, and priapism.	heparin	allergic	10726030	1
-However, additional important untoward effects of heparin therapy include heparin-induced thrombocytopenia, heparin-associated osteoporosis, eosinophilia, skin reactions, allergic reactions other than thrombocytopenia, alopecia, transaminasemia, hyperkalemia, hypoaldosteronism, and priapism.	heparin	hyperkalemia	10726030	1
-However, additional important untoward effects of heparin therapy include heparin-induced thrombocytopenia, heparin-associated osteoporosis, eosinophilia, skin reactions, allergic reactions other than thrombocytopenia, alopecia, transaminasemia, hyperkalemia, hypoaldosteronism, and priapism.	heparin	thrombocytopenia	10726030	1
-However, additional important untoward effects of heparin therapy include heparin-induced thrombocytopenia, heparin-associated osteoporosis, eosinophilia, skin reactions, allergic reactions other than thrombocytopenia, alopecia, transaminasemia, hyperkalemia, hypoaldosteronism, and priapism.	heparin	thrombocytopenia	10726030	1
-However, additional important untoward effects of heparin therapy include heparin-induced thrombocytopenia, heparin-associated osteoporosis, eosinophilia, skin reactions, allergic reactions other than thrombocytopenia, alopecia, transaminasemia, hyperkalemia, hypoaldosteronism, and priapism.	heparin	osteoporosis	10726030	1
-However, additional important untoward effects of heparin therapy include heparin-induced thrombocytopenia, heparin-associated osteoporosis, eosinophilia, skin reactions, allergic reactions other than thrombocytopenia, alopecia, transaminasemia, hyperkalemia, hypoaldosteronism, and priapism.	heparin	allergic	10726030	1
-We examined the potential role of prostaglandins in the development of analgesic nephropathy in the Gunn strain of rat.	prostaglandins	nephropathy	3864191	-1
-In a series of five experiments, the modulating role of naloxone on a scopolamine-induced retention deficit in a passive avoidance paradigm was investigated in mice.	scopolamine	retention deficit	3088653	-1
-In a series of five experiments, the modulating role of naloxone on a scopolamine-induced retention deficit in a passive avoidance paradigm was investigated in mice.	naloxone	retention deficit	3088653	-1
-The role of nitric oxide in convulsions induced by lindane in rats.	nitric oxide	convulsions	21195121	-1
-Sixty normotensive American Society of Anesthesiologists I-II adult patients undergoing FESS under controlled hypotension anesthesia caused by propofol-remifentanil-TIVA were randomly assigned into two groups: group I, FRLMA; group II, ETT.	propofol-remifentanil-TIVA	hypotension	19178808	1
-The aim of our study was to re-examine the association between risk of VTE and OC use with a different study design and analysis to avoid some of the bias and confounding of the earlier studies.	OC	VTE	8996419	-1
-Vasopressin as a possible contributor to hypertension.	Vasopressin	hypertension	6321816	-1
-We recently demonstrated that recombinant hGH exacerbates renal functional and structural injury in chronic puromycin aminonucleoside (PAN) nephropathy, an experimental model of glomerular disease.	puromycin aminonucleoside	nephropathy	8825380	1
-We recently demonstrated that recombinant hGH exacerbates renal functional and structural injury in chronic puromycin aminonucleoside (PAN) nephropathy, an experimental model of glomerular disease.	puromycin aminonucleoside	structural injury	8825380	-1
-We recently demonstrated that recombinant hGH exacerbates renal functional and structural injury in chronic puromycin aminonucleoside (PAN) nephropathy, an experimental model of glomerular disease.	PAN	glomerular disease	8825380	1
-We recently demonstrated that recombinant hGH exacerbates renal functional and structural injury in chronic puromycin aminonucleoside (PAN) nephropathy, an experimental model of glomerular disease.	PAN	structural injury	8825380	-1
-Dehydrated rats regularly develop acute renal failure following single injection of aminoglycoside antibiotics combined with dextran or of antibiotics only.	dextran	acute renal failure	931801	-1
-Dehydrated rats regularly develop acute renal failure following single injection of aminoglycoside antibiotics combined with dextran or of antibiotics only.	aminoglycoside	acute renal failure	931801	1
-Maleate-induced renal injury included increase in renal vascular resistance and in the urinary excretion of total protein, glucose, sodium, neutrophil gelatinase-associated lipocalin (NGAL) and N-acetyl b-D-glucosaminidase (NAG), upregulation of kidney injury molecule (KIM)-1, decrease in renal blood flow and claudin-2 expression besides of necrosis and apoptosis of tubular cells on 24 h. Oxidative stress was determined by measuring the oxidation of lipids and proteins and diminution in renal Nrf2 levels.	glucose	necrosis	25119790	-1
-Maleate-induced renal injury included increase in renal vascular resistance and in the urinary excretion of total protein, glucose, sodium, neutrophil gelatinase-associated lipocalin (NGAL) and N-acetyl b-D-glucosaminidase (NAG), upregulation of kidney injury molecule (KIM)-1, decrease in renal blood flow and claudin-2 expression besides of necrosis and apoptosis of tubular cells on 24 h. Oxidative stress was determined by measuring the oxidation of lipids and proteins and diminution in renal Nrf2 levels.	glucose	renal injury	25119790	-1
-Maleate-induced renal injury included increase in renal vascular resistance and in the urinary excretion of total protein, glucose, sodium, neutrophil gelatinase-associated lipocalin (NGAL) and N-acetyl b-D-glucosaminidase (NAG), upregulation of kidney injury molecule (KIM)-1, decrease in renal blood flow and claudin-2 expression besides of necrosis and apoptosis of tubular cells on 24 h. Oxidative stress was determined by measuring the oxidation of lipids and proteins and diminution in renal Nrf2 levels.	glucose	kidney injury	25119790	-1
-Maleate-induced renal injury included increase in renal vascular resistance and in the urinary excretion of total protein, glucose, sodium, neutrophil gelatinase-associated lipocalin (NGAL) and N-acetyl b-D-glucosaminidase (NAG), upregulation of kidney injury molecule (KIM)-1, decrease in renal blood flow and claudin-2 expression besides of necrosis and apoptosis of tubular cells on 24 h. Oxidative stress was determined by measuring the oxidation of lipids and proteins and diminution in renal Nrf2 levels.	Maleate	necrosis	25119790	-1
-Maleate-induced renal injury included increase in renal vascular resistance and in the urinary excretion of total protein, glucose, sodium, neutrophil gelatinase-associated lipocalin (NGAL) and N-acetyl b-D-glucosaminidase (NAG), upregulation of kidney injury molecule (KIM)-1, decrease in renal blood flow and claudin-2 expression besides of necrosis and apoptosis of tubular cells on 24 h. Oxidative stress was determined by measuring the oxidation of lipids and proteins and diminution in renal Nrf2 levels.	Maleate	renal injury	25119790	-1
-Maleate-induced renal injury included increase in renal vascular resistance and in the urinary excretion of total protein, glucose, sodium, neutrophil gelatinase-associated lipocalin (NGAL) and N-acetyl b-D-glucosaminidase (NAG), upregulation of kidney injury molecule (KIM)-1, decrease in renal blood flow and claudin-2 expression besides of necrosis and apoptosis of tubular cells on 24 h. Oxidative stress was determined by measuring the oxidation of lipids and proteins and diminution in renal Nrf2 levels.	Maleate	kidney injury	25119790	-1
-Maleate-induced renal injury included increase in renal vascular resistance and in the urinary excretion of total protein, glucose, sodium, neutrophil gelatinase-associated lipocalin (NGAL) and N-acetyl b-D-glucosaminidase (NAG), upregulation of kidney injury molecule (KIM)-1, decrease in renal blood flow and claudin-2 expression besides of necrosis and apoptosis of tubular cells on 24 h. Oxidative stress was determined by measuring the oxidation of lipids and proteins and diminution in renal Nrf2 levels.	sodium	necrosis	25119790	-1
-Maleate-induced renal injury included increase in renal vascular resistance and in the urinary excretion of total protein, glucose, sodium, neutrophil gelatinase-associated lipocalin (NGAL) and N-acetyl b-D-glucosaminidase (NAG), upregulation of kidney injury molecule (KIM)-1, decrease in renal blood flow and claudin-2 expression besides of necrosis and apoptosis of tubular cells on 24 h. Oxidative stress was determined by measuring the oxidation of lipids and proteins and diminution in renal Nrf2 levels.	sodium	renal injury	25119790	-1
-Maleate-induced renal injury included increase in renal vascular resistance and in the urinary excretion of total protein, glucose, sodium, neutrophil gelatinase-associated lipocalin (NGAL) and N-acetyl b-D-glucosaminidase (NAG), upregulation of kidney injury molecule (KIM)-1, decrease in renal blood flow and claudin-2 expression besides of necrosis and apoptosis of tubular cells on 24 h. Oxidative stress was determined by measuring the oxidation of lipids and proteins and diminution in renal Nrf2 levels.	sodium	kidney injury	25119790	-1
-Conversion to sirolimus ameliorates cyclosporine-induced nephropathy in the rat: focus on serum, urine, gene, and protein renal expression biomarkers.	sirolimus	nephropathy	24971338	-1
-After the addition of clonidine 0.15 mg bid she developed complete AV block, which resolved after all therapy was stopped.	clonidine	AV block	7949506	1
-The muscarinic cholinergic agonist pilocarpine induces in rats seizures and status epilepticus followed by widespread damage to the forebrain.	pilocarpine	status epilepticus	3191389	1
-The muscarinic cholinergic agonist pilocarpine induces in rats seizures and status epilepticus followed by widespread damage to the forebrain.	pilocarpine	seizures	3191389	1
-These results may be relevant to the use of FZP in clinical situations in which there is increased neural excitability, such as epilepsy or sedative-hypnotic drug withdrawal.	FZP	epilepsy	6106951	-1
-Four hundred two patients with suspected myocardial infarction seen within 6 hours of the onset of symptoms entered a double-blind randomized trial of lidocaine vs placebo.	lidocaine	myocardial infarction	3895875	-1
-Oral treatment with Memantine (10mg/kg) and Ibuprofen (50 mg/kg) daily for 13 days attenuated STZ induced glial activation, apoptotic cell death and post synaptic neurotoxicity in rat brain.	STZ	synaptic neurotoxicity	24333387	-1
-Oral treatment with Memantine (10mg/kg) and Ibuprofen (50 mg/kg) daily for 13 days attenuated STZ induced glial activation, apoptotic cell death and post synaptic neurotoxicity in rat brain.	STZ	death	24333387	-1
-Oral treatment with Memantine (10mg/kg) and Ibuprofen (50 mg/kg) daily for 13 days attenuated STZ induced glial activation, apoptotic cell death and post synaptic neurotoxicity in rat brain.	Memantine	synaptic neurotoxicity	24333387	-1
-Oral treatment with Memantine (10mg/kg) and Ibuprofen (50 mg/kg) daily for 13 days attenuated STZ induced glial activation, apoptotic cell death and post synaptic neurotoxicity in rat brain.	Memantine	death	24333387	-1
-Oral treatment with Memantine (10mg/kg) and Ibuprofen (50 mg/kg) daily for 13 days attenuated STZ induced glial activation, apoptotic cell death and post synaptic neurotoxicity in rat brain.	Ibuprofen	synaptic neurotoxicity	24333387	-1
-Oral treatment with Memantine (10mg/kg) and Ibuprofen (50 mg/kg) daily for 13 days attenuated STZ induced glial activation, apoptotic cell death and post synaptic neurotoxicity in rat brain.	Ibuprofen	death	24333387	-1
-Cocaine-induced hyperactivity is more influenced by adenosine receptor agonists than amphetamine-induced hyperactivity.	adenosine	hyperactivity	12523489	-1
-Cocaine-induced hyperactivity is more influenced by adenosine receptor agonists than amphetamine-induced hyperactivity.	adenosine	hyperactivity	12523489	-1
-Cocaine-induced hyperactivity is more influenced by adenosine receptor agonists than amphetamine-induced hyperactivity.	Cocaine	hyperactivity	12523489	-1
-Cocaine-induced hyperactivity is more influenced by adenosine receptor agonists than amphetamine-induced hyperactivity.	Cocaine	hyperactivity	12523489	-1
-Cocaine-induced hyperactivity is more influenced by adenosine receptor agonists than amphetamine-induced hyperactivity.	amphetamine	hyperactivity	12523489	-1
-Cocaine-induced hyperactivity is more influenced by adenosine receptor agonists than amphetamine-induced hyperactivity.	amphetamine	hyperactivity	12523489	-1
-The influence of adenosine receptor agonists and antagonists on cocaine-and amphetamine-induced hyperactivity was examined in mice.	cocaine	hyperactivity	12523489	-1
-The influence of adenosine receptor agonists and antagonists on cocaine-and amphetamine-induced hyperactivity was examined in mice.	adenosine	hyperactivity	12523489	-1
-The influence of adenosine receptor agonists and antagonists on cocaine-and amphetamine-induced hyperactivity was examined in mice.	amphetamine	hyperactivity	12523489	-1
-Dose-dependent neurotoxicity of high-dose busulfan in children: a clinical and pharmacological study.	busulfan	neurotoxicity	2400986	-1
-In this study, we investigated the effect of chronic administration of LF on oxidative stress and hypertension upon Dex administration.	Dex	hypertension	24587916	1
-In this study, we investigated the effect of chronic administration of LF on oxidative stress and hypertension upon Dex administration.	LF	hypertension	24587916	-1
-Half log incremental doses of intravenous methoxamine or placebo (saline) were administered to a group of women with genuine stress incontinence while measuring maximum urethral pressure (MUP), blood pressure, heart rate, and symptomatic side effects.	methoxamine	stress incontinence	11135381	-1
-Busulfan is known to be neurotoxic in animals and humans, but its acute neurotoxicity remains poorly characterized in children.	Busulfan	neurotoxic	2400986	-1
-Busulfan is known to be neurotoxic in animals and humans, but its acute neurotoxicity remains poorly characterized in children.	Busulfan	neurotoxicity	2400986	-1
-It evokes convulsions mainly trough the blockage of GABA(A) receptors.	GABA(A	convulsions	21195121	-1
-RATIONALE: Ecstasy (MDMA) is a psychostimulant drug which is increasingly associated with psychobiological dysfunction. While some recent studies suggest acute changes in neuroendocrine function, less is known about long-term changes in HPA functionality in recreational users.	Ecstasy	psychobiological dysfunction	24190587	-1
-RATIONALE: Ecstasy (MDMA) is a psychostimulant drug which is increasingly associated with psychobiological dysfunction. While some recent studies suggest acute changes in neuroendocrine function, less is known about long-term changes in HPA functionality in recreational users.	MDMA	psychobiological dysfunction	24190587	-1
-We report here a retrospective study of 123 children (median age, 6.5 years) receiving high-dose busulfan in combined chemotherapy before bone marrow transplantation for malignant solid tumors, brain tumors excluded.	busulfan	tumors	2400986	-1
-We report here a retrospective study of 123 children (median age, 6.5 years) receiving high-dose busulfan in combined chemotherapy before bone marrow transplantation for malignant solid tumors, brain tumors excluded.	busulfan	brain tumors	2400986	-1
-The association between psychiatric co-morbidity and methamphetamine-induced psychosis was also studied.	methamphetamine	psychiatric	23433219	-1
-However, no reports are available on the role of Ca(2+) in aconitine poisoning.	aconitine	poisoning	24840785	1
-However, no reports are available on the role of Ca(2+) in aconitine poisoning.	Ca(2	poisoning	24840785	-1
-We investigated the effects of clentiazem, a 1,5-benzothiazepine calcium antagonist, on epinephrine-induced cardiomyopathy in rats.	1,5-benzothiazepine	cardiomyopathy	8392553	-1
-We investigated the effects of clentiazem, a 1,5-benzothiazepine calcium antagonist, on epinephrine-induced cardiomyopathy in rats.	epinephrine	cardiomyopathy	8392553	1
-We investigated the effects of clentiazem, a 1,5-benzothiazepine calcium antagonist, on epinephrine-induced cardiomyopathy in rats.	clentiazem	cardiomyopathy	8392553	-1
-We investigated the effects of clentiazem, a 1,5-benzothiazepine calcium antagonist, on epinephrine-induced cardiomyopathy in rats.	calcium	cardiomyopathy	8392553	-1
-CONCLUSIONS: GLS combined with cTnT may provide a reliable and non-invasive method to predict cardiac dysfunction in patients receiving anthracycline-based chemotherapy.	anthracycline	cardiac dysfunction	24464946	-1
-Renal lesions were analyzed in hematoxylin and eosin, periodic acid-Schiff, and Masson's trichrome stains.	periodic acid	Renal lesions	24971338	-1
-Since chemotherapeutic agent toxicity generally correlates with dose per body surface area, we retrospectively calculated the dose of CYA in patients transplanted at our institution to determine whether the incidence of CYA cardiotoxicity correlated with the dose per body surface area.	CYA	cardiotoxicity	3533179	-1
-Since chemotherapeutic agent toxicity generally correlates with dose per body surface area, we retrospectively calculated the dose of CYA in patients transplanted at our institution to determine whether the incidence of CYA cardiotoxicity correlated with the dose per body surface area.	CYA	toxicity	3533179	-1
-Since chemotherapeutic agent toxicity generally correlates with dose per body surface area, we retrospectively calculated the dose of CYA in patients transplanted at our institution to determine whether the incidence of CYA cardiotoxicity correlated with the dose per body surface area.	CYA	cardiotoxicity	3533179	-1
-Since chemotherapeutic agent toxicity generally correlates with dose per body surface area, we retrospectively calculated the dose of CYA in patients transplanted at our institution to determine whether the incidence of CYA cardiotoxicity correlated with the dose per body surface area.	CYA	toxicity	3533179	-1
-Application of an irreversible inhibitor of GABA transaminase, gamma-vinyl-GABA (D,L-4-amino-hex-5-enoic acid), 5 micrograms, into the SNR, bilaterally, suppressed the appearance of electrographic and behavioral seizures produced by pilocarpine, 380 mg/kg.	D,L-4-amino-hex-5-enoic acid	seizures	3708328	-1
-Application of an irreversible inhibitor of GABA transaminase, gamma-vinyl-GABA (D,L-4-amino-hex-5-enoic acid), 5 micrograms, into the SNR, bilaterally, suppressed the appearance of electrographic and behavioral seizures produced by pilocarpine, 380 mg/kg.	GABA	seizures	3708328	-1
-Application of an irreversible inhibitor of GABA transaminase, gamma-vinyl-GABA (D,L-4-amino-hex-5-enoic acid), 5 micrograms, into the SNR, bilaterally, suppressed the appearance of electrographic and behavioral seizures produced by pilocarpine, 380 mg/kg.	gamma-vinyl-GABA	seizures	3708328	-1
-Application of an irreversible inhibitor of GABA transaminase, gamma-vinyl-GABA (D,L-4-amino-hex-5-enoic acid), 5 micrograms, into the SNR, bilaterally, suppressed the appearance of electrographic and behavioral seizures produced by pilocarpine, 380 mg/kg.	pilocarpine	seizures	3708328	1
-RESULTS: L-NOARG sub-chronic administration produced tolerance of L-NOARG and of haloperidol-induced catalepsy.	haloperidol	catalepsy	10672628	1
-Nitric oxide (NO), gaseous neurotransmitter, has contradictor role in epileptogenesis due to opposite effects of L-arginine, precursor of NO syntheses (NOS), and L-NAME (NOS inhibitor) observed in different epilepsy models.	Nitric oxide	epilepsy	21195121	-1
-Nitric oxide (NO), gaseous neurotransmitter, has contradictor role in epileptogenesis due to opposite effects of L-arginine, precursor of NO syntheses (NOS), and L-NAME (NOS inhibitor) observed in different epilepsy models.	NO	epilepsy	21195121	-1
-Nitric oxide (NO), gaseous neurotransmitter, has contradictor role in epileptogenesis due to opposite effects of L-arginine, precursor of NO syntheses (NOS), and L-NAME (NOS inhibitor) observed in different epilepsy models.	NO	epilepsy	21195121	-1
-These findings are strong support for the adrenaline-hypertension hypothesis in man.	adrenaline	hypertension hypothesis	2904523	1
-Invasive carcinoma of the renal pelvis following cyclophosphamide therapy for nonmalignant disease.	cyclophosphamide	carcinoma of the renal pelvis	7248895	-1
-Bleeding is the primary untoward effect of heparin.	heparin	Bleeding	10726030	-1
-Reduced cardiotoxicity of doxorubicin given in the form of N-(2-hydroxypropyl)methacrylamide conjugates: and experimental study in the rat.	N-(2-hydroxypropyl)methacrylamide	cardiotoxicity	1760851	-1
-Atrial thrombosis involving the heart of F-344 rats ingesting quinacrine hydrochloride.	quinacrine hydrochloride	Atrial thrombosis	6517710	-1
-Etoposide (VP-16-213) has been used in the treatment of many solid tumors and hematologic malignancies.	Etoposide	tumors	3289726	-1
-Etoposide (VP-16-213) has been used in the treatment of many solid tumors and hematologic malignancies.	Etoposide	hematologic malignancies	3289726	-1
-Etoposide (VP-16-213) has been used in the treatment of many solid tumors and hematologic malignancies.	VP-16-213	tumors	3289726	-1
-Etoposide (VP-16-213) has been used in the treatment of many solid tumors and hematologic malignancies.	VP-16-213	hematologic malignancies	3289726	-1
-A rat model was used to evaluate the general acute toxicity and the late cardiotoxicity of 4 mg/kg doxorubicin (DOX) given either as free drug or in the form of three N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer conjugates.	doxorubicin	cardiotoxicity	1760851	1
-A rat model was used to evaluate the general acute toxicity and the late cardiotoxicity of 4 mg/kg doxorubicin (DOX) given either as free drug or in the form of three N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer conjugates.	doxorubicin	toxicity	1760851	-1
-A rat model was used to evaluate the general acute toxicity and the late cardiotoxicity of 4 mg/kg doxorubicin (DOX) given either as free drug or in the form of three N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer conjugates.	DOX	cardiotoxicity	1760851	1
-A rat model was used to evaluate the general acute toxicity and the late cardiotoxicity of 4 mg/kg doxorubicin (DOX) given either as free drug or in the form of three N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer conjugates.	DOX	toxicity	1760851	-1
-A rat model was used to evaluate the general acute toxicity and the late cardiotoxicity of 4 mg/kg doxorubicin (DOX) given either as free drug or in the form of three N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer conjugates.	N-(2-hydroxypropyl)methacrylamide	cardiotoxicity	1760851	-1
-A rat model was used to evaluate the general acute toxicity and the late cardiotoxicity of 4 mg/kg doxorubicin (DOX) given either as free drug or in the form of three N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer conjugates.	N-(2-hydroxypropyl)methacrylamide	toxicity	1760851	-1
-A rat model was used to evaluate the general acute toxicity and the late cardiotoxicity of 4 mg/kg doxorubicin (DOX) given either as free drug or in the form of three N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer conjugates.	HPMA	cardiotoxicity	1760851	-1
-A rat model was used to evaluate the general acute toxicity and the late cardiotoxicity of 4 mg/kg doxorubicin (DOX) given either as free drug or in the form of three N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer conjugates.	HPMA	toxicity	1760851	-1
-SRL-treated rats presented proteinuria and NGAL (serum and urinary) as the best markers of renal impairment.	SRL	renal impairment	24971338	-1
-SRL-treated rats presented proteinuria and NGAL (serum and urinary) as the best markers of renal impairment.	SRL	proteinuria	24971338	1
-Four (10.8%) patients in the conventional group and 1 (2.7%) in the unilateral group, P= 0.17 required epinephrine infusion to treat hypotension.	epinephrine	hypotension	18399341	-1
-This was further supported by results showing that nonconvulsive doses of NMDA and pilocarpine were synergistic, resulting in status epilepticus and subsequent mortality.	pilocarpine	status epilepticus	2553470	1
-It may serve as an alternative to cisplatin-containing regimens; however, it has to be considered that possibly HUS may occur.	cisplatin	HUS	12119460	-1
-The data indicate that a bulbospinal serotonergic pathway is involved in development of clonidine-induced hypotension and bradycardia.	clonidine	hypotension	3423103	1
-The data indicate that a bulbospinal serotonergic pathway is involved in development of clonidine-induced hypotension and bradycardia.	clonidine	bradycardia	3423103	1
-The aim of the current study was to determine the effects of NO on the behavioral and EEG characteristics of lindane-induced epilepsy in male Wistar albino rats.	lindane	epilepsy	21195121	-1
-The aim of the current study was to determine the effects of NO on the behavioral and EEG characteristics of lindane-induced epilepsy in male Wistar albino rats.	NO	epilepsy	21195121	-1
-Complicated depressive disorders (including atypicality of course and symptomatology, chronicity, psychosis, bipolarity, and secondary onset in the course of a primary psychosis) may present particular vulnerability to paranoid exacerbations associated with serotonin reuptake inhibitors.	serotonin	bipolarity	1837756	-1
-Complicated depressive disorders (including atypicality of course and symptomatology, chronicity, psychosis, bipolarity, and secondary onset in the course of a primary psychosis) may present particular vulnerability to paranoid exacerbations associated with serotonin reuptake inhibitors.	serotonin	depressive disorders	1837756	-1
-Complicated depressive disorders (including atypicality of course and symptomatology, chronicity, psychosis, bipolarity, and secondary onset in the course of a primary psychosis) may present particular vulnerability to paranoid exacerbations associated with serotonin reuptake inhibitors.	serotonin	paranoid	1837756	-1
-Complicated depressive disorders (including atypicality of course and symptomatology, chronicity, psychosis, bipolarity, and secondary onset in the course of a primary psychosis) may present particular vulnerability to paranoid exacerbations associated with serotonin reuptake inhibitors.	serotonin	psychosis	1837756	-1
-Complicated depressive disorders (including atypicality of course and symptomatology, chronicity, psychosis, bipolarity, and secondary onset in the course of a primary psychosis) may present particular vulnerability to paranoid exacerbations associated with serotonin reuptake inhibitors.	serotonin	psychosis	1837756	-1
-Frequency of appearance of myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) in Graves' disease patients treated with propylthiouracil and the relationship between MPO-ANCA and clinical manifestations.	propylthiouracil	Graves' disease	11380496	-1
-Vincristine was accidentally given intrathecally to a child with leukaemia, producing sensory and motor dysfunction followed by encephalopathy and death.	Vincristine	death	1280054	-1
-Vincristine was accidentally given intrathecally to a child with leukaemia, producing sensory and motor dysfunction followed by encephalopathy and death.	Vincristine	leukaemia	1280054	-1
-4 cases of endometrial carcinoma referred from elsewhere demonstrated the problems of inappropriate and unsupervised unopposed oestrogen therapy and the difficulty in distinguishing severe hyperplasia from malignancy.	oestrogen	malignancy	89511	-1
-4 cases of endometrial carcinoma referred from elsewhere demonstrated the problems of inappropriate and unsupervised unopposed oestrogen therapy and the difficulty in distinguishing severe hyperplasia from malignancy.	oestrogen	hyperplasia	89511	1
-4 cases of endometrial carcinoma referred from elsewhere demonstrated the problems of inappropriate and unsupervised unopposed oestrogen therapy and the difficulty in distinguishing severe hyperplasia from malignancy.	oestrogen	endometrial carcinoma	89511	-1
-S-312-d may be useful in the therapy of certain types of human epilepsy.	S-312-d	epilepsy	7967231	-1
-OBJECTIVE: Myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA)-positive vasculitis has been reported in patients with Graves' disease who were treated with propylthiouracil (PTU).	propylthiouracil	vasculitis	11380496	-1
-OBJECTIVE: Myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA)-positive vasculitis has been reported in patients with Graves' disease who were treated with propylthiouracil (PTU).	propylthiouracil	Graves' disease	11380496	-1
-OBJECTIVE: Myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA)-positive vasculitis has been reported in patients with Graves' disease who were treated with propylthiouracil (PTU).	PTU	vasculitis	11380496	-1
-OBJECTIVE: Myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA)-positive vasculitis has been reported in patients with Graves' disease who were treated with propylthiouracil (PTU).	PTU	Graves' disease	11380496	-1
-It is concluded that advanced pregnancy has a negligible effect on the neurotoxic response to theophylline in rats.	theophylline	neurotoxic	3339945	-1
-Thus, the investigations did not provide any evidence that the beta-receptor blockers propranolol and B 24/76 have the potency to prevent isoproterenol from producing heart hypertrophy.	isoproterenol	hypertrophy	2974281	-1
-Thus, the investigations did not provide any evidence that the beta-receptor blockers propranolol and B 24/76 have the potency to prevent isoproterenol from producing heart hypertrophy.	propranolol	hypertrophy	2974281	-1
-Nevertheless, there have been no studies on the temporal relationship between the appearance of MPO-ANCA and vasculitis during PTU therapy, or on the incidence of MPO-ANCA in untreated Graves' disease patients.	PTU	vasculitis	11380496	-1
-Nevertheless, there have been no studies on the temporal relationship between the appearance of MPO-ANCA and vasculitis during PTU therapy, or on the incidence of MPO-ANCA in untreated Graves' disease patients.	PTU	Graves' disease	11380496	-1
-Thalidomide neuropathy in patients treated for metastatic prostate cancer.	Thalidomide	prostate cancer	11439380	-1
-Thalidomide neuropathy in patients treated for metastatic prostate cancer.	Thalidomide	neuropathy	11439380	-1
-We prospectively evaluated thalidomide-induced neuropathy using electrodiagnostic studies.	thalidomide	neuropathy	11439380	-1
-PATIENTS: We investigated 102 untreated patients with hyperthyroidism due to Graves' disease for the presence of MPO-ANCA, and for the development vasculitis after starting PTU therapy.	PTU	hyperthyroidism	11380496	-1
-PATIENTS: We investigated 102 untreated patients with hyperthyroidism due to Graves' disease for the presence of MPO-ANCA, and for the development vasculitis after starting PTU therapy.	PTU	vasculitis	11380496	-1
-PATIENTS: We investigated 102 untreated patients with hyperthyroidism due to Graves' disease for the presence of MPO-ANCA, and for the development vasculitis after starting PTU therapy.	PTU	Graves' disease	11380496	-1
-Subacute effects of propranolol and B 24/76 on isoproterenol-induced rat heart hypertrophy in correlation with blood pressure.	isoproterenol	hypertrophy	2974281	-1
-Subacute effects of propranolol and B 24/76 on isoproterenol-induced rat heart hypertrophy in correlation with blood pressure.	propranolol	hypertrophy	2974281	-1
-The effects of progesterone treatment on bupivacaine arrhythmogenicity in beating rat heart myocyte cultures and on anesthetized rats were determined.	bupivacaine	arrhythmogenicity	1280707	-1
-The effects of progesterone treatment on bupivacaine arrhythmogenicity in beating rat heart myocyte cultures and on anesthetized rats were determined.	progesterone	arrhythmogenicity	1280707	-1
-The ischemia probably induced by coronary artery spasm was reversed by nitroglycerin and calcium blocking agents.	nitroglycerin	ischemia	8511251	-1
-The ischemia probably induced by coronary artery spasm was reversed by nitroglycerin and calcium blocking agents.	nitroglycerin	coronary artery spasm	8511251	-1
-The ischemia probably induced by coronary artery spasm was reversed by nitroglycerin and calcium blocking agents.	calcium	ischemia	8511251	-1
-The ischemia probably induced by coronary artery spasm was reversed by nitroglycerin and calcium blocking agents.	calcium	coronary artery spasm	8511251	-1
-The role of vasopressin as a pressor agent to the hypertensive process was examined.	vasopressin	hypertensive	6321816	-1
-After the addition of a minimal dose of clonidine (0.15 mg bid), she developed complete AV block and severe hypotension, which resolved upon cessation of all medications.	clonidine	hypotension	7949506	1
-Therefore, we examined whether recombinant human (rh) IGF-I is a safer alternative for the treatment of growth failure in rats with chronic PAN nephropathy.	PAN	growth failure	8825380	-1
-Therefore, we examined whether recombinant human (rh) IGF-I is a safer alternative for the treatment of growth failure in rats with chronic PAN nephropathy.	PAN	nephropathy	8825380	1
-We saw no association between metolachlor use and incidence of all cancers combined (n = 5,701 with a 5-year lag) or most site-specific cancers.	metolachlor	cancers	26033014	-1
-We saw no association between metolachlor use and incidence of all cancers combined (n = 5,701 with a 5-year lag) or most site-specific cancers.	metolachlor	cancers	26033014	-1
-Prolonged left ventricular dysfunction occurs in patients with coronary artery disease after both dobutamine and exercise induced myocardial ischaemia.	dobutamine	coronary artery disease	10677406	-1
-Prolonged left ventricular dysfunction occurs in patients with coronary artery disease after both dobutamine and exercise induced myocardial ischaemia.	dobutamine	myocardial ischaemia	10677406	-1
-Pronounced changes in the surface ECG (cycle length, QT, and QTc) in relation to the dose of oral d,l-sotalol might identify a subgroup of patients with an increased risk for torsades de pointes.	l-sotalol	torsades de pointes	9125676	1
-Levodopa-induced ocular dyskinesias are very uncommon.	Levodopa	ocular dyskinesias	11835460	-1
-DESIGN: A randomised crossover study of recovery time of systolic and diastolic left ventricular function after exercise and dobutamine induced ischaemia.	dobutamine	ischaemia	10677406	-1
-Convulsion following intravenous fluorescein angiography.	fluorescein	Convulsion	2765447	-1
-On the contrary, pretreatment with L-NAME (500, 700 and 900 mg/kg, i.p.) decreased convulsion incidence and severity and prolonged latency time to convulsion following injection with a convulsive dose of lindane (8 mg/kg, i.p.).	lindane	convulsion	21195121	1
-On the contrary, pretreatment with L-NAME (500, 700 and 900 mg/kg, i.p.) decreased convulsion incidence and severity and prolonged latency time to convulsion following injection with a convulsive dose of lindane (8 mg/kg, i.p.).	lindane	convulsion	21195121	1
-On the contrary, pretreatment with L-NAME (500, 700 and 900 mg/kg, i.p.) decreased convulsion incidence and severity and prolonged latency time to convulsion following injection with a convulsive dose of lindane (8 mg/kg, i.p.).	lindane	convulsive	21195121	1
-There was a significant decrease in the time to onset of arrhythmia as compared with control nonprogesterone-treated rats (6.2 +/-	control nonprogesterone	arrhythmia	1280707	-1
-Abnormalities of the pupil and visual-evoked potential in quinine amblyopia.	quinine	amblyopia	7369302	1
-Both isomers of propranolol were capable of preventing adrenaline-induced cardiac arrhythmias in cats anaesthetized with halothane, but the mean dose of (-)-propranolol was 0.09+/-0.02 mg/kg whereas that of (+)-propranolol was 4.2+/-1.2 mg/kg.	halothane	cardiac arrhythmias	19108278	1
-Both isomers of propranolol were capable of preventing adrenaline-induced cardiac arrhythmias in cats anaesthetized with halothane, but the mean dose of (-)-propranolol was 0.09+/-0.02 mg/kg whereas that of (+)-propranolol was 4.2+/-1.2 mg/kg.	propranolol	cardiac arrhythmias	19108278	-1
-Both isomers of propranolol were capable of preventing adrenaline-induced cardiac arrhythmias in cats anaesthetized with halothane, but the mean dose of (-)-propranolol was 0.09+/-0.02 mg/kg whereas that of (+)-propranolol was 4.2+/-1.2 mg/kg.	-)-propranolol	cardiac arrhythmias	19108278	-1
-Both isomers of propranolol were capable of preventing adrenaline-induced cardiac arrhythmias in cats anaesthetized with halothane, but the mean dose of (-)-propranolol was 0.09+/-0.02 mg/kg whereas that of (+)-propranolol was 4.2+/-1.2 mg/kg.	-propranolol	cardiac arrhythmias	19108278	-1
-The results of this study indicate that progesterone can potentiate bupivacaine arrhythmogenicity both in vivo and in vitro.	bupivacaine	arrhythmogenicity	1280707	-1
-The results of this study indicate that progesterone can potentiate bupivacaine arrhythmogenicity both in vivo and in vitro.	progesterone	arrhythmogenicity	1280707	-1
-As tranexamic acid is the only modifiable factor, its administration, particularly in doses exceeding 80 mg.kg(-1), should be weighed against the risk of postoperative seizures.	tranexamic acid	postoperative seizures	24588023	-1
-Neuropathy may thus be a common complication of thalidomide in older patients.	thalidomide	Neuropathy	11439380	-1
-An unexpected diagnosis in a renal-transplant patient with proteinuria treated with everolimus: AL amyloidosis.	everolimus	AL amyloidosis	24040781	-1
-Normoammonemic encephalopathy: solely valproate induced or multiple mechanisms?	valproate	encephalopathy	24614773	-1
-Hyperosmolar nonketotic coma precipitated by lithium-induced nephrogenic diabetes insipidus.	lithium	Hyperosmolar nonketotic coma	9538487	1
-Hyperosmolar nonketotic coma precipitated by lithium-induced nephrogenic diabetes insipidus.	lithium	nephrogenic diabetes insipidus	9538487	1
-The studies were performed using an experimental model of isoproterenol-induced heart hypertrophy in rats.	isoproterenol	heart hypertrophy	2974281	-1
-CONCLUSIONS: In patients with coronary artery disease, dobutamine induced ischaemia results in prolonged reversible left ventricular dysfunction, presumed to be myocardial stunning, similar to that seen after exercise.	dobutamine	ischaemia	10677406	-1
-CONCLUSIONS: In patients with coronary artery disease, dobutamine induced ischaemia results in prolonged reversible left ventricular dysfunction, presumed to be myocardial stunning, similar to that seen after exercise.	dobutamine	coronary artery disease	10677406	-1
-In conclusion, MT induction halts BCNU-induced hippocampal toxicity as it prevented GR inhibition and GSH depletion and counteracted the increased levels of TNFalpha, MDA and caspase-3 activity with subsequent preservation of cognition.	MT	toxicity	20046642	-1
-In conclusion, MT induction halts BCNU-induced hippocampal toxicity as it prevented GR inhibition and GSH depletion and counteracted the increased levels of TNFalpha, MDA and caspase-3 activity with subsequent preservation of cognition.	TNFalpha	toxicity	20046642	-1
-In conclusion, MT induction halts BCNU-induced hippocampal toxicity as it prevented GR inhibition and GSH depletion and counteracted the increased levels of TNFalpha, MDA and caspase-3 activity with subsequent preservation of cognition.	GSH	toxicity	20046642	-1
-In conclusion, MT induction halts BCNU-induced hippocampal toxicity as it prevented GR inhibition and GSH depletion and counteracted the increased levels of TNFalpha, MDA and caspase-3 activity with subsequent preservation of cognition.	MDA	toxicity	20046642	-1
-In conclusion, MT induction halts BCNU-induced hippocampal toxicity as it prevented GR inhibition and GSH depletion and counteracted the increased levels of TNFalpha, MDA and caspase-3 activity with subsequent preservation of cognition.	BCNU	toxicity	20046642	-1
-Dobutamine induced ischaemia could therefore be used to study the pathophysiology of this phenomenon further in patients with coronary artery disease.	Dobutamine	ischaemia	10677406	-1
-Dobutamine induced ischaemia could therefore be used to study the pathophysiology of this phenomenon further in patients with coronary artery disease.	Dobutamine	coronary artery disease	10677406	-1
-Asterixis induced by carbamazepine therapy.	carbamazepine	Asterixis	1420650	-1
-We report a case of hypersensitivity myocarditis secondary to administration of carbamazepine.	carbamazepine	hypersensitivity myocarditis	20129423	1
-We studied the efficacy and safety of propranolol in the treatment of PPA-induced hypertension.	propranolol	hypertension	3987172	-1
-DISCUSSION: Daptomycin was initiated in our patient secondary to possible nafcillin-induced acute interstitial nephritis and relapsing bacteremia.	Daptomycin	bacteremia	20959502	-1
-DISCUSSION: Daptomycin was initiated in our patient secondary to possible nafcillin-induced acute interstitial nephritis and relapsing bacteremia.	Daptomycin	interstitial nephritis	20959502	-1
-DISCUSSION: Daptomycin was initiated in our patient secondary to possible nafcillin-induced acute interstitial nephritis and relapsing bacteremia.	nafcillin	bacteremia	20959502	-1
-Throughout the study (20 weeks), deaths related to cardiotoxicity were observed only in animals that received either free DOX or the mixture of HPMA copolymer and free DOX; in these cases, histological investigations revealed marked changes in the heart that were consistent with DOX-induced cardiotoxicity.	DOX	cardiotoxicity	1760851	1
-Throughout the study (20 weeks), deaths related to cardiotoxicity were observed only in animals that received either free DOX or the mixture of HPMA copolymer and free DOX; in these cases, histological investigations revealed marked changes in the heart that were consistent with DOX-induced cardiotoxicity.	DOX	cardiotoxicity	1760851	1
-Throughout the study (20 weeks), deaths related to cardiotoxicity were observed only in animals that received either free DOX or the mixture of HPMA copolymer and free DOX; in these cases, histological investigations revealed marked changes in the heart that were consistent with DOX-induced cardiotoxicity.	DOX	cardiotoxicity	1760851	1
-Throughout the study (20 weeks), deaths related to cardiotoxicity were observed only in animals that received either free DOX or the mixture of HPMA copolymer and free DOX; in these cases, histological investigations revealed marked changes in the heart that were consistent with DOX-induced cardiotoxicity.	DOX	cardiotoxicity	1760851	1
-Throughout the study (20 weeks), deaths related to cardiotoxicity were observed only in animals that received either free DOX or the mixture of HPMA copolymer and free DOX; in these cases, histological investigations revealed marked changes in the heart that were consistent with DOX-induced cardiotoxicity.	HPMA	cardiotoxicity	1760851	-1
-Throughout the study (20 weeks), deaths related to cardiotoxicity were observed only in animals that received either free DOX or the mixture of HPMA copolymer and free DOX; in these cases, histological investigations revealed marked changes in the heart that were consistent with DOX-induced cardiotoxicity.	HPMA	cardiotoxicity	1760851	-1
-Prevalence of heart disease in asymptomatic chronic cocaine users.	cocaine	heart disease	11385188	-1
-We report on a patient with leftward and upward deviations of gaze during the peak effect of levodopa, and hypothesize that a severe dopaminergic denervation in the caudate nucleus is needed for the appearance of these levodopa-induce ocular dyskinesias.	levodopa	ocular dyskinesias	11835460	-1
-We report on a patient with leftward and upward deviations of gaze during the peak effect of levodopa, and hypothesize that a severe dopaminergic denervation in the caudate nucleus is needed for the appearance of these levodopa-induce ocular dyskinesias.	levodopa	ocular dyskinesias	11835460	-1
-Urinary protein excretion was unaltered by rhIGF-I treatment in rats with chronic PAN nephropathy.	PAN	nephropathy	8825380	1
-Eighty patients who were to receive CYA 50 mg/kg/d for four days as preparation for marrow grafting underwent a total of 84 transplants for aplastic anemia, Wiskott-Aldrich syndrome, or severe combined immunodeficiency syndrome.	CYA	aplastic anemia	3533179	-1
-Eighty patients who were to receive CYA 50 mg/kg/d for four days as preparation for marrow grafting underwent a total of 84 transplants for aplastic anemia, Wiskott-Aldrich syndrome, or severe combined immunodeficiency syndrome.	CYA	Wiskott-Aldrich syndrome	3533179	-1
-Eighty patients who were to receive CYA 50 mg/kg/d for four days as preparation for marrow grafting underwent a total of 84 transplants for aplastic anemia, Wiskott-Aldrich syndrome, or severe combined immunodeficiency syndrome.	CYA	immunodeficiency syndrome	3533179	-1
-To determine the prevalence of heart disease in outpatient young asymptomatic chronic cocaine users, 35 cocaine users and 32 age-matched controls underwent resting and exercise electrocardiography (ECG) and Doppler echocardiography.	cocaine	heart disease	11385188	-1
-To determine the prevalence of heart disease in outpatient young asymptomatic chronic cocaine users, 35 cocaine users and 32 age-matched controls underwent resting and exercise electrocardiography (ECG) and Doppler echocardiography.	cocaine	heart disease	11385188	-1
-High-dose methotrexate (HD-MTX) is an important treatment for Burkitt lymphoma, but can cause hepatic and renal toxicity when its clearance is delayed.	methotrexate	renal toxicity	20009434	-1
-High-dose methotrexate (HD-MTX) is an important treatment for Burkitt lymphoma, but can cause hepatic and renal toxicity when its clearance is delayed.	methotrexate	Burkitt lymphoma	20009434	-1
-High-dose methotrexate (HD-MTX) is an important treatment for Burkitt lymphoma, but can cause hepatic and renal toxicity when its clearance is delayed.	HD-MTX	renal toxicity	20009434	-1
-High-dose methotrexate (HD-MTX) is an important treatment for Burkitt lymphoma, but can cause hepatic and renal toxicity when its clearance is delayed.	HD-MTX	Burkitt lymphoma	20009434	-1
-BACKGROUND: The activity of the combination of carboplatin and liposomal doxorubicin was tested in a Phase II study of patients with recurrent cervical carcinoma.	doxorubicin	carcinoma	11745287	-1
-BACKGROUND: The activity of the combination of carboplatin and liposomal doxorubicin was tested in a Phase II study of patients with recurrent cervical carcinoma.	carboplatin	carcinoma	11745287	-1
-We have described a patient with severe rheumatoid arthritis and a history of mefenamic acid nephropathy in whom hyperkalemia and inappropriate hypoaldosteronism were caused by both indomethacin and naproxen, without major decline in renal function.	indomethacin	rheumatoid arthritis	3375885	-1
-We have described a patient with severe rheumatoid arthritis and a history of mefenamic acid nephropathy in whom hyperkalemia and inappropriate hypoaldosteronism were caused by both indomethacin and naproxen, without major decline in renal function.	indomethacin	nephropathy	3375885	-1
-We have described a patient with severe rheumatoid arthritis and a history of mefenamic acid nephropathy in whom hyperkalemia and inappropriate hypoaldosteronism were caused by both indomethacin and naproxen, without major decline in renal function.	indomethacin	inappropriate hypoaldosteronism	3375885	1
-We have described a patient with severe rheumatoid arthritis and a history of mefenamic acid nephropathy in whom hyperkalemia and inappropriate hypoaldosteronism were caused by both indomethacin and naproxen, without major decline in renal function.	naproxen	rheumatoid arthritis	3375885	-1
-We have described a patient with severe rheumatoid arthritis and a history of mefenamic acid nephropathy in whom hyperkalemia and inappropriate hypoaldosteronism were caused by both indomethacin and naproxen, without major decline in renal function.	naproxen	hyperkalemia	3375885	1
-We have described a patient with severe rheumatoid arthritis and a history of mefenamic acid nephropathy in whom hyperkalemia and inappropriate hypoaldosteronism were caused by both indomethacin and naproxen, without major decline in renal function.	naproxen	nephropathy	3375885	-1
-We have described a patient with severe rheumatoid arthritis and a history of mefenamic acid nephropathy in whom hyperkalemia and inappropriate hypoaldosteronism were caused by both indomethacin and naproxen, without major decline in renal function.	naproxen	inappropriate hypoaldosteronism	3375885	1
-We have described a patient with severe rheumatoid arthritis and a history of mefenamic acid nephropathy in whom hyperkalemia and inappropriate hypoaldosteronism were caused by both indomethacin and naproxen, without major decline in renal function.	mefenamic acid	rheumatoid arthritis	3375885	-1
-We have described a patient with severe rheumatoid arthritis and a history of mefenamic acid nephropathy in whom hyperkalemia and inappropriate hypoaldosteronism were caused by both indomethacin and naproxen, without major decline in renal function.	mefenamic acid	hyperkalemia	3375885	-1
-We have described a patient with severe rheumatoid arthritis and a history of mefenamic acid nephropathy in whom hyperkalemia and inappropriate hypoaldosteronism were caused by both indomethacin and naproxen, without major decline in renal function.	mefenamic acid	inappropriate hypoaldosteronism	3375885	-1
-Co-morbid major depressive disorder (OR=7.18, 95 CI=2.612-19.708), bipolar disorder (OR=13.807, 95 CI=5.194-36.706), antisocial personality disorder (OR=12.619, 95 CI=6.702-23.759) and heavy methamphetamine uses were significantly associated with lifetime methamphetamine-induced psychosis after adjusted for other factors.	methamphetamine	bipolar disorder	23433219	1
-Co-morbid major depressive disorder (OR=7.18, 95 CI=2.612-19.708), bipolar disorder (OR=13.807, 95 CI=5.194-36.706), antisocial personality disorder (OR=12.619, 95 CI=6.702-23.759) and heavy methamphetamine uses were significantly associated with lifetime methamphetamine-induced psychosis after adjusted for other factors.	methamphetamine	depressive disorder	23433219	-1
-Co-morbid major depressive disorder (OR=7.18, 95 CI=2.612-19.708), bipolar disorder (OR=13.807, 95 CI=5.194-36.706), antisocial personality disorder (OR=12.619, 95 CI=6.702-23.759) and heavy methamphetamine uses were significantly associated with lifetime methamphetamine-induced psychosis after adjusted for other factors.	methamphetamine	personality disorder	23433219	-1
-Co-morbid major depressive disorder (OR=7.18, 95 CI=2.612-19.708), bipolar disorder (OR=13.807, 95 CI=5.194-36.706), antisocial personality disorder (OR=12.619, 95 CI=6.702-23.759) and heavy methamphetamine uses were significantly associated with lifetime methamphetamine-induced psychosis after adjusted for other factors.	methamphetamine	psychosis	23433219	1
-Co-morbid major depressive disorder (OR=7.18, 95 CI=2.612-19.708), bipolar disorder (OR=13.807, 95 CI=5.194-36.706), antisocial personality disorder (OR=12.619, 95 CI=6.702-23.759) and heavy methamphetamine uses were significantly associated with lifetime methamphetamine-induced psychosis after adjusted for other factors.	methamphetamine	bipolar disorder	23433219	1
-Co-morbid major depressive disorder (OR=7.18, 95 CI=2.612-19.708), bipolar disorder (OR=13.807, 95 CI=5.194-36.706), antisocial personality disorder (OR=12.619, 95 CI=6.702-23.759) and heavy methamphetamine uses were significantly associated with lifetime methamphetamine-induced psychosis after adjusted for other factors.	methamphetamine	depressive disorder	23433219	-1
-Co-morbid major depressive disorder (OR=7.18, 95 CI=2.612-19.708), bipolar disorder (OR=13.807, 95 CI=5.194-36.706), antisocial personality disorder (OR=12.619, 95 CI=6.702-23.759) and heavy methamphetamine uses were significantly associated with lifetime methamphetamine-induced psychosis after adjusted for other factors.	methamphetamine	personality disorder	23433219	-1
-To examine the role of the kinin B2 receptor in cisplatin-induced acute kidney injury, kinin B2 receptor knockout mice were challenged with cisplatin.	cisplatin	acute kidney injury	24975837	1
-To examine the role of the kinin B2 receptor in cisplatin-induced acute kidney injury, kinin B2 receptor knockout mice were challenged with cisplatin.	cisplatin	acute kidney injury	24975837	1
-In the present study, we describe the proinflammatory effects of bupivacaine on local prostaglandin E2 (PGE2) production and cyclooxygenase (COX) gene expression that increases postoperative pain in human subjects.	prostaglandin E2	postoperative pain	18165598	-1
-In the present study, we describe the proinflammatory effects of bupivacaine on local prostaglandin E2 (PGE2) production and cyclooxygenase (COX) gene expression that increases postoperative pain in human subjects.	PGE2	postoperative pain	18165598	-1
-GFC produced an increased latency to first seizure, at doses 25mg/kg (20.12 + 2.20 min), 50mg/kg (20.95 + 2.21 min) or 75 mg/kg (23.43 + 1.99 min) when compared with seized mice.	GFC	seizure	24911645	-1
-We wish to draw attention to the possibility of adverse reactions to ACE inhibitors after long-term use and in patients with pre-existing angio-oedema.	ACE inhibitors	angio-oedema	7671401	-1
-Of the 83 cases of VTE associated with use of combined OCs, 43 were recorded as deep-vein thrombosis, 35 as pulmonary thrombosis, and five as venous thrombosis not otherwise specified.	OCs	vein thrombosis	8996419	-1
-Of the 83 cases of VTE associated with use of combined OCs, 43 were recorded as deep-vein thrombosis, 35 as pulmonary thrombosis, and five as venous thrombosis not otherwise specified.	OCs	venous thrombosis	8996419	-1
-Of the 83 cases of VTE associated with use of combined OCs, 43 were recorded as deep-vein thrombosis, 35 as pulmonary thrombosis, and five as venous thrombosis not otherwise specified.	OCs	VTE	8996419	1
-Of the 83 cases of VTE associated with use of combined OCs, 43 were recorded as deep-vein thrombosis, 35 as pulmonary thrombosis, and five as venous thrombosis not otherwise specified.	OCs	pulmonary thrombosis	8996419	-1
-Indomethacin resulted in histopathologic findings typical of interstitial cystitis, such as leaky bladder epithelium and mucosal mastocytosis.	Indomethacin	mastocytosis	12559315	1
-Indomethacin resulted in histopathologic findings typical of interstitial cystitis, such as leaky bladder epithelium and mucosal mastocytosis.	Indomethacin	interstitial cystitis	12559315	1
-Although the pharmacology and neurobiology of paranoia remain cryptic, several mechanisms, including 5HT3 receptor-mediated dopamine release, beta-noradrenergic receptor downregulation, or GABAB receptor upregulation acting in the vicinity of the ventral basal ganglia (possibly in lateral orbitofrontal or anterior cingulate circuits), might apply to this phenomenon.	dopamine	paranoia	1837756	-1
-Seventy-one percent of the patients reported that the behavioral effects of caffeine were similar to those experienced during panic attacks.	caffeine	panic attacks	2983630	-1
-These results demonstrated that PCE could induce dysplasia of fetal kidneys as well as glomerulosclerosis of adult offspring, and the low functional programming of renal AT2R might mediate the developmental origin of adult glomerulosclerosis.	PCE	glomerulosclerosis	25986755	-1
-These results demonstrated that PCE could induce dysplasia of fetal kidneys as well as glomerulosclerosis of adult offspring, and the low functional programming of renal AT2R might mediate the developmental origin of adult glomerulosclerosis.	PCE	glomerulosclerosis	25986755	-1
-These results demonstrated that PCE could induce dysplasia of fetal kidneys as well as glomerulosclerosis of adult offspring, and the low functional programming of renal AT2R might mediate the developmental origin of adult glomerulosclerosis.	PCE	dysplasia of fetal kidneys	25986755	1
-HIT must be acknowledged for its intense predilection for thrombosis and suspected whenever thrombosis occurs after heparin exposure.	heparin	HIT	20495512	1
-HIT must be acknowledged for its intense predilection for thrombosis and suspected whenever thrombosis occurs after heparin exposure.	heparin	thrombosis	20495512	1
-HIT must be acknowledged for its intense predilection for thrombosis and suspected whenever thrombosis occurs after heparin exposure.	heparin	thrombosis	20495512	1
-In this report we present four patients treated with a combination of different psychotropic drugs, in whom asterixis was triggered either by adding carbamazepine (CBZ) to a treatment regimen, or by increasing its dosage.	carbamazepine	asterixis	1420650	-1
-In this report we present four patients treated with a combination of different psychotropic drugs, in whom asterixis was triggered either by adding carbamazepine (CBZ) to a treatment regimen, or by increasing its dosage.	CBZ	asterixis	1420650	-1
-No necrosis was observed in cells treated with NCQ436 but NCQ344 had a biphasic effect in both cell types, inducing apoptosis at lower concentrations and necrosis at higher concentrations.	NCQ436	necrosis	10462057	-1
-No necrosis was observed in cells treated with NCQ436 but NCQ344 had a biphasic effect in both cell types, inducing apoptosis at lower concentrations and necrosis at higher concentrations.	NCQ436	necrosis	10462057	-1
-No necrosis was observed in cells treated with NCQ436 but NCQ344 had a biphasic effect in both cell types, inducing apoptosis at lower concentrations and necrosis at higher concentrations.	NCQ344	necrosis	10462057	-1
-No necrosis was observed in cells treated with NCQ436 but NCQ344 had a biphasic effect in both cell types, inducing apoptosis at lower concentrations and necrosis at higher concentrations.	NCQ344	necrosis	10462057	-1
-Chronic pulsatile levodopa therapy for Parkinson's disease (PD) leads to the development of motor fluctuations and dyskinesia.	levodopa	Parkinson's disease	23952588	-1
-Chronic pulsatile levodopa therapy for Parkinson's disease (PD) leads to the development of motor fluctuations and dyskinesia.	levodopa	PD	23952588	-1
-Chronic pulsatile levodopa therapy for Parkinson's disease (PD) leads to the development of motor fluctuations and dyskinesia.	levodopa	dyskinesia	23952588	1
-Caution is recommended in combining clonidine and verapamil therapy, even in patients who do not have sinus or AV node dysfunction.	verapamil	AV node dysfunction	7949506	-1
-Caution is recommended in combining clonidine and verapamil therapy, even in patients who do not have sinus or AV node dysfunction.	clonidine	AV node dysfunction	7949506	-1
-A 77-year-old woman with refractory multiple myeloma was treated with a 4-day continuous intravenous infusion of vincristine and doxorubicin and 4 days of oral dexamethasone.	doxorubicin	multiple myeloma	1424076	-1
-A 77-year-old woman with refractory multiple myeloma was treated with a 4-day continuous intravenous infusion of vincristine and doxorubicin and 4 days of oral dexamethasone.	vincristine	multiple myeloma	1424076	-1
-A 77-year-old woman with refractory multiple myeloma was treated with a 4-day continuous intravenous infusion of vincristine and doxorubicin and 4 days of oral dexamethasone.	dexamethasone	multiple myeloma	1424076	-1
-We herein report the case of a 70-year-old man with 5-FU-induced cardiotoxicity, in whom a high serum level of alpha-fluoro-beta-alanine (FBAL) was observed.	5-FU	cardiotoxicity	16369751	-1
-We herein report the case of a 70-year-old man with 5-FU-induced cardiotoxicity, in whom a high serum level of alpha-fluoro-beta-alanine (FBAL) was observed.	alpha-fluoro-beta-alanine	cardiotoxicity	16369751	-1
-We herein report the case of a 70-year-old man with 5-FU-induced cardiotoxicity, in whom a high serum level of alpha-fluoro-beta-alanine (FBAL) was observed.	FBAL	cardiotoxicity	16369751	-1
-Tranexamic acid overdosage-induced generalized seizure in renal failure. We report a 45-year-old lady with chronic kidney disease stage 4 due to chronic tubulointerstial disease.	Tranexamic acid	seizure	24434397	-1
-Tranexamic acid overdosage-induced generalized seizure in renal failure. We report a 45-year-old lady with chronic kidney disease stage 4 due to chronic tubulointerstial disease.	Tranexamic acid	chronic kidney disease	24434397	-1
-Tranexamic acid overdosage-induced generalized seizure in renal failure. We report a 45-year-old lady with chronic kidney disease stage 4 due to chronic tubulointerstial disease.	Tranexamic acid	renal failure	24434397	-1
-During the last 2 1/2 years, 38 patients with ovarian cancer were treated with a combination of cisplatinum (CPDD), 50 mg/m2, adriamycin, 30 mg/m2, cyclophosphamide, 300 mg/m2, on day 1; and hexamethylmelamine (HMM), 6 mg/kg daily, for 14 days.	adriamycin	ovarian cancer	6806735	-1
-During the last 2 1/2 years, 38 patients with ovarian cancer were treated with a combination of cisplatinum (CPDD), 50 mg/m2, adriamycin, 30 mg/m2, cyclophosphamide, 300 mg/m2, on day 1; and hexamethylmelamine (HMM), 6 mg/kg daily, for 14 days.	cyclophosphamide	ovarian cancer	6806735	-1
-During the last 2 1/2 years, 38 patients with ovarian cancer were treated with a combination of cisplatinum (CPDD), 50 mg/m2, adriamycin, 30 mg/m2, cyclophosphamide, 300 mg/m2, on day 1; and hexamethylmelamine (HMM), 6 mg/kg daily, for 14 days.	cisplatinum	ovarian cancer	6806735	-1
-During the last 2 1/2 years, 38 patients with ovarian cancer were treated with a combination of cisplatinum (CPDD), 50 mg/m2, adriamycin, 30 mg/m2, cyclophosphamide, 300 mg/m2, on day 1; and hexamethylmelamine (HMM), 6 mg/kg daily, for 14 days.	hexamethylmelamine	ovarian cancer	6806735	-1
-During the last 2 1/2 years, 38 patients with ovarian cancer were treated with a combination of cisplatinum (CPDD), 50 mg/m2, adriamycin, 30 mg/m2, cyclophosphamide, 300 mg/m2, on day 1; and hexamethylmelamine (HMM), 6 mg/kg daily, for 14 days.	HMM	ovarian cancer	6806735	-1
-We propose that remoxipride and benzene may induce aplastic anemia via production of similar reactive metabolites and that the ability of NCQ436 and NCQ344 to induce apoptosis in HBMP cells may contribute to the mechanism underlying acquired aplastic anemia that has been associated with remoxipride.	NCQ436	aplastic anemia	10462057	-1
-We propose that remoxipride and benzene may induce aplastic anemia via production of similar reactive metabolites and that the ability of NCQ436 and NCQ344 to induce apoptosis in HBMP cells may contribute to the mechanism underlying acquired aplastic anemia that has been associated with remoxipride.	NCQ436	aplastic anemia	10462057	-1
-We propose that remoxipride and benzene may induce aplastic anemia via production of similar reactive metabolites and that the ability of NCQ436 and NCQ344 to induce apoptosis in HBMP cells may contribute to the mechanism underlying acquired aplastic anemia that has been associated with remoxipride.	remoxipride	aplastic anemia	10462057	1
-We propose that remoxipride and benzene may induce aplastic anemia via production of similar reactive metabolites and that the ability of NCQ436 and NCQ344 to induce apoptosis in HBMP cells may contribute to the mechanism underlying acquired aplastic anemia that has been associated with remoxipride.	remoxipride	aplastic anemia	10462057	1
-We propose that remoxipride and benzene may induce aplastic anemia via production of similar reactive metabolites and that the ability of NCQ436 and NCQ344 to induce apoptosis in HBMP cells may contribute to the mechanism underlying acquired aplastic anemia that has been associated with remoxipride.	benzene	aplastic anemia	10462057	1
-We propose that remoxipride and benzene may induce aplastic anemia via production of similar reactive metabolites and that the ability of NCQ436 and NCQ344 to induce apoptosis in HBMP cells may contribute to the mechanism underlying acquired aplastic anemia that has been associated with remoxipride.	benzene	aplastic anemia	10462057	1
-We propose that remoxipride and benzene may induce aplastic anemia via production of similar reactive metabolites and that the ability of NCQ436 and NCQ344 to induce apoptosis in HBMP cells may contribute to the mechanism underlying acquired aplastic anemia that has been associated with remoxipride.	NCQ344	aplastic anemia	10462057	-1
-We propose that remoxipride and benzene may induce aplastic anemia via production of similar reactive metabolites and that the ability of NCQ436 and NCQ344 to induce apoptosis in HBMP cells may contribute to the mechanism underlying acquired aplastic anemia that has been associated with remoxipride.	NCQ344	aplastic anemia	10462057	-1
-Sixty-seven men with metastatic androgen-independent prostate cancer in an open-label trial of oral thalidomide underwent neurologic examinations and nerve conduction studies (NCS) prior to and at 3-month intervals during treatment.	thalidomide	prostate cancer	11439380	-1
-Efficacy of olanzapine in acute bipolar mania: a double-blind, placebo-controlled study.	olanzapine	bipolar mania	10986547	-1
-The participation of reactive oxygen species in aminoglycoside-induced ototoxicity has been deduced from observations that aminoglycoside-iron complexes catalyze the formation of superoxide radicals in vitro and that antioxidants attenuate ototoxicity in vivo.	iron	ototoxicity	11474137	-1
-The participation of reactive oxygen species in aminoglycoside-induced ototoxicity has been deduced from observations that aminoglycoside-iron complexes catalyze the formation of superoxide radicals in vitro and that antioxidants attenuate ototoxicity in vivo.	iron	ototoxicity	11474137	-1
-The participation of reactive oxygen species in aminoglycoside-induced ototoxicity has been deduced from observations that aminoglycoside-iron complexes catalyze the formation of superoxide radicals in vitro and that antioxidants attenuate ototoxicity in vivo.	oxygen	ototoxicity	11474137	-1
-The participation of reactive oxygen species in aminoglycoside-induced ototoxicity has been deduced from observations that aminoglycoside-iron complexes catalyze the formation of superoxide radicals in vitro and that antioxidants attenuate ototoxicity in vivo.	oxygen	ototoxicity	11474137	-1
-The participation of reactive oxygen species in aminoglycoside-induced ototoxicity has been deduced from observations that aminoglycoside-iron complexes catalyze the formation of superoxide radicals in vitro and that antioxidants attenuate ototoxicity in vivo.	aminoglycoside	ototoxicity	11474137	-1
-The participation of reactive oxygen species in aminoglycoside-induced ototoxicity has been deduced from observations that aminoglycoside-iron complexes catalyze the formation of superoxide radicals in vitro and that antioxidants attenuate ototoxicity in vivo.	aminoglycoside	ototoxicity	11474137	-1
-The participation of reactive oxygen species in aminoglycoside-induced ototoxicity has been deduced from observations that aminoglycoside-iron complexes catalyze the formation of superoxide radicals in vitro and that antioxidants attenuate ototoxicity in vivo.	aminoglycoside	ototoxicity	11474137	-1
-The participation of reactive oxygen species in aminoglycoside-induced ototoxicity has been deduced from observations that aminoglycoside-iron complexes catalyze the formation of superoxide radicals in vitro and that antioxidants attenuate ototoxicity in vivo.	aminoglycoside	ototoxicity	11474137	-1
-The participation of reactive oxygen species in aminoglycoside-induced ototoxicity has been deduced from observations that aminoglycoside-iron complexes catalyze the formation of superoxide radicals in vitro and that antioxidants attenuate ototoxicity in vivo.	superoxide	ototoxicity	11474137	-1
-The participation of reactive oxygen species in aminoglycoside-induced ototoxicity has been deduced from observations that aminoglycoside-iron complexes catalyze the formation of superoxide radicals in vitro and that antioxidants attenuate ototoxicity in vivo.	superoxide	ototoxicity	11474137	-1
-Clinical aspects of heparin-induced thrombocytopenia and thrombosis and other side effects of heparin therapy.	heparin	thrombosis	10726030	-1
-Clinical aspects of heparin-induced thrombocytopenia and thrombosis and other side effects of heparin therapy.	heparin	thrombosis	10726030	-1
-BACKGROUND: We compared the efficacy and safety of olanzapine vs placebo for the treatment of acute bipolar mania.	olanzapine	bipolar mania	10986547	-1
-Lidocaine, given in a 300 mg dose intramuscularly followed by 100 mg intravenously, did not prevent sustained ventricular tachycardia, although there was a significant reduction in the number of patients with warning arrhythmias between 15 and 45 minutes after the administration of lidocaine (p less than 0.05).	Lidocaine	arrhythmias	3895875	-1
-Lidocaine, given in a 300 mg dose intramuscularly followed by 100 mg intravenously, did not prevent sustained ventricular tachycardia, although there was a significant reduction in the number of patients with warning arrhythmias between 15 and 45 minutes after the administration of lidocaine (p less than 0.05).	Lidocaine	ventricular tachycardia	3895875	-1
-Lidocaine, given in a 300 mg dose intramuscularly followed by 100 mg intravenously, did not prevent sustained ventricular tachycardia, although there was a significant reduction in the number of patients with warning arrhythmias between 15 and 45 minutes after the administration of lidocaine (p less than 0.05).	lidocaine	arrhythmias	3895875	-1
-Lidocaine, given in a 300 mg dose intramuscularly followed by 100 mg intravenously, did not prevent sustained ventricular tachycardia, although there was a significant reduction in the number of patients with warning arrhythmias between 15 and 45 minutes after the administration of lidocaine (p less than 0.05).	lidocaine	ventricular tachycardia	3895875	-1
-The level of GFAP, CD11b, TNF-a, ROS and nitrite levels were increased.	nitrite	TNF	24333387	-1
-Heparin, first used to prevent the clotting of blood in vitro, has been clinically used to treat thrombosis for more than 50 years.	Heparin	thrombosis	10726030	-1
-We consider asterixis to be an easily overlooked sign of neurotoxicity, which may occur even at low or moderate dosage levels, if certain drugs as lithium or clozapine are used in combination with CBZ.	clozapine	neurotoxicity	1420650	-1
-We consider asterixis to be an easily overlooked sign of neurotoxicity, which may occur even at low or moderate dosage levels, if certain drugs as lithium or clozapine are used in combination with CBZ.	clozapine	asterixis	1420650	1
-We consider asterixis to be an easily overlooked sign of neurotoxicity, which may occur even at low or moderate dosage levels, if certain drugs as lithium or clozapine are used in combination with CBZ.	lithium	neurotoxicity	1420650	-1
-We consider asterixis to be an easily overlooked sign of neurotoxicity, which may occur even at low or moderate dosage levels, if certain drugs as lithium or clozapine are used in combination with CBZ.	lithium	asterixis	1420650	1
-We consider asterixis to be an easily overlooked sign of neurotoxicity, which may occur even at low or moderate dosage levels, if certain drugs as lithium or clozapine are used in combination with CBZ.	CBZ	neurotoxicity	1420650	-1
-We consider asterixis to be an easily overlooked sign of neurotoxicity, which may occur even at low or moderate dosage levels, if certain drugs as lithium or clozapine are used in combination with CBZ.	CBZ	asterixis	1420650	-1
-The diagnosis of metronidazole toxicity was made by the MRI findings and supported clinically.	metronidazole	toxicity	24816962	-1
-This complication may result from an inhibition of prostaglandin synthesis and consequent hyporeninemic hypoaidosteronism.	prostaglandin	hyporeninemic hypoaidosteronism	7411769	-1
-One month of oral galactose treatment initiated immediately after the STZ-icv administration, successfully prevented development of the STZ-icv-induced cognitive deficits.	STZ	cognitive deficits	24055495	1
-One month of oral galactose treatment initiated immediately after the STZ-icv administration, successfully prevented development of the STZ-icv-induced cognitive deficits.	galactose	cognitive deficits	24055495	1
-Neutropenia was the principal toxic effect, and the overall frequency of grade 4 neutropenia after the first treatment of CCNU/CTX was 30% (95% confidence interval, 19-43%).	CCNU	Neutropenia	24659727	1
-Neutropenia was the principal toxic effect, and the overall frequency of grade 4 neutropenia after the first treatment of CCNU/CTX was 30% (95% confidence interval, 19-43%).	CCNU	neutropenia	24659727	1
-Neutropenia was the principal toxic effect, and the overall frequency of grade 4 neutropenia after the first treatment of CCNU/CTX was 30% (95% confidence interval, 19-43%).	CTX	Neutropenia	24659727	-1
-Neutropenia was the principal toxic effect, and the overall frequency of grade 4 neutropenia after the first treatment of CCNU/CTX was 30% (95% confidence interval, 19-43%).	CTX	neutropenia	24659727	-1
-desmethylimipramine (0.3 mg), while propranolol (0.5 mg) i.v. selectively inhibited the enlargement of pulse pressure and the tachycardia following i.c.	desmethylimipramine	tachycardia	978847	-1
-desmethylimipramine (0.3 mg), while propranolol (0.5 mg) i.v. selectively inhibited the enlargement of pulse pressure and the tachycardia following i.c.	propranolol	tachycardia	978847	-1
-The protection by overexpression of superoxide dismutase supports the hypothesis that oxidant stress plays a significant role in aminoglycoside-induced ototoxicity.	aminoglycoside	ototoxicity	11474137	-1
-The protection by overexpression of superoxide dismutase supports the hypothesis that oxidant stress plays a significant role in aminoglycoside-induced ototoxicity.	superoxide	ototoxicity	11474137	-1
-Cardiotoxicity that was thought to be related to CYA occurred in 1/32 (3%) of patients in Group 1 and in 13/52 (25%) patients in Group 2 (P less than 0.025).	CYA	Cardiotoxicity	3533179	-1
-As heparin remains one of the most frequently used medications today with potential for HIT with every heparin exposure, a close vigilance of platelet counts must be practiced whenever heparin is initiated.	heparin	HIT	20495512	1
-As heparin remains one of the most frequently used medications today with potential for HIT with every heparin exposure, a close vigilance of platelet counts must be practiced whenever heparin is initiated.	heparin	HIT	20495512	1
-Niacin extended-release/lovastatin is a new combination product approved for treatment of primary hypercholesterolemia and mixed dyslipidemia.	lovastatin	primary hypercholesterolemia	15276093	-1
-Niacin extended-release/lovastatin is a new combination product approved for treatment of primary hypercholesterolemia and mixed dyslipidemia.	lovastatin	dyslipidemia	15276093	-1
-Niacin extended-release/lovastatin is a new combination product approved for treatment of primary hypercholesterolemia and mixed dyslipidemia.	Niacin	primary hypercholesterolemia	15276093	-1
-Niacin extended-release/lovastatin is a new combination product approved for treatment of primary hypercholesterolemia and mixed dyslipidemia.	Niacin	dyslipidemia	15276093	-1
-Hexabrix and Vasurix polyvidone are considered the best contrast media for hysterosalpingography and perhaps because of its low toxicity Hexabrix should be preferred.	polyvidone	toxicity	7173007	-1
-Increased vulnerability to 6-hydroxydopamine lesion and reduced development of dyskinesias in mice lacking CB1 cannabinoid receptors.	CB1 cannabinoid	dyskinesias	19419794	-1
-Increased vulnerability to 6-hydroxydopamine lesion and reduced development of dyskinesias in mice lacking CB1 cannabinoid receptors.	6-hydroxydopamine	dyskinesias	19419794	-1
-Histologic evidence of cardiotoxicity scored as grade III was only observed at a dose of 1.0 mg doxorubicin/kg.	doxorubicin	cardiotoxicity	6585590	-1
-A naloxone (5 mg/kg) challenge was also ineffective in altering the seizure thresholds of either control of MSG-treated mice.	naloxone	seizure	3685052	-1
-Patients also received dietary counseling, educational materials, and reminders to call a toll-free number that provided further education about dyslipidemia and niacin extended-release/lovastatin.	lovastatin	dyslipidemia	15276093	-1
-Patients also received dietary counseling, educational materials, and reminders to call a toll-free number that provided further education about dyslipidemia and niacin extended-release/lovastatin.	niacin	dyslipidemia	15276093	-1
-These complications have included clinical deterioration and intracranial vascular thrombosis in patients with SAH, arteriolar and capillary fibrin thrombi in patients with fibrinolytic syndromes treated with EACA, or other thromboembolic phenomena.	EACA	thromboembolic	448423	-1
-These complications have included clinical deterioration and intracranial vascular thrombosis in patients with SAH, arteriolar and capillary fibrin thrombi in patients with fibrinolytic syndromes treated with EACA, or other thromboembolic phenomena.	EACA	SAH	448423	1
-These complications have included clinical deterioration and intracranial vascular thrombosis in patients with SAH, arteriolar and capillary fibrin thrombi in patients with fibrinolytic syndromes treated with EACA, or other thromboembolic phenomena.	EACA	fibrinolytic syndromes	448423	-1
-These complications have included clinical deterioration and intracranial vascular thrombosis in patients with SAH, arteriolar and capillary fibrin thrombi in patients with fibrinolytic syndromes treated with EACA, or other thromboembolic phenomena.	EACA	intracranial vascular thrombosis	448423	1
-CONCLUSIONS: We found an increased incidence of subependymal cyst formation in preterm infants who were exposed to cocaine prenatally.	cocaine	subependymal cyst	11425091	-1
-The reduction of amphetamine hyperactivity induced by DSP4 was blocked by pretreatment with the noradrenaline-uptake blocking agent, desipramine, which prevents the neurotoxic action of DSP4.	DSP4	neurotoxic	6687006	-1
-The reduction of amphetamine hyperactivity induced by DSP4 was blocked by pretreatment with the noradrenaline-uptake blocking agent, desipramine, which prevents the neurotoxic action of DSP4.	DSP4	hyperactivity	6687006	-1
-The reduction of amphetamine hyperactivity induced by DSP4 was blocked by pretreatment with the noradrenaline-uptake blocking agent, desipramine, which prevents the neurotoxic action of DSP4.	DSP4	neurotoxic	6687006	-1
-The reduction of amphetamine hyperactivity induced by DSP4 was blocked by pretreatment with the noradrenaline-uptake blocking agent, desipramine, which prevents the neurotoxic action of DSP4.	DSP4	hyperactivity	6687006	-1
-The reduction of amphetamine hyperactivity induced by DSP4 was blocked by pretreatment with the noradrenaline-uptake blocking agent, desipramine, which prevents the neurotoxic action of DSP4.	desipramine	neurotoxic	6687006	-1
-The reduction of amphetamine hyperactivity induced by DSP4 was blocked by pretreatment with the noradrenaline-uptake blocking agent, desipramine, which prevents the neurotoxic action of DSP4.	desipramine	hyperactivity	6687006	-1
-The reduction of amphetamine hyperactivity induced by DSP4 was blocked by pretreatment with the noradrenaline-uptake blocking agent, desipramine, which prevents the neurotoxic action of DSP4.	amphetamine	neurotoxic	6687006	-1
-The reduction of amphetamine hyperactivity induced by DSP4 was blocked by pretreatment with the noradrenaline-uptake blocking agent, desipramine, which prevents the neurotoxic action of DSP4.	amphetamine	hyperactivity	6687006	-1
-The reduction of amphetamine hyperactivity induced by DSP4 was blocked by pretreatment with the noradrenaline-uptake blocking agent, desipramine, which prevents the neurotoxic action of DSP4.	noradrenaline	neurotoxic	6687006	-1
-The reduction of amphetamine hyperactivity induced by DSP4 was blocked by pretreatment with the noradrenaline-uptake blocking agent, desipramine, which prevents the neurotoxic action of DSP4.	noradrenaline	hyperactivity	6687006	-1
-These cases call attention to possible paranoid exacerbations with serotonin reuptake blockers in select patients and raise neurobiological considerations regarding paranoia.	serotonin	paranoid	1837756	-1
-These cases call attention to possible paranoid exacerbations with serotonin reuptake blockers in select patients and raise neurobiological considerations regarding paranoia.	serotonin	paranoia	1837756	-1
-Estradiol treatment also increased the arrhythmogenicity of bupivacaine in myocyte cultures, but was only one fourth as potent as progesterone.	bupivacaine	arrhythmogenicity	1280707	-1
-Estradiol treatment also increased the arrhythmogenicity of bupivacaine in myocyte cultures, but was only one fourth as potent as progesterone.	Estradiol	arrhythmogenicity	1280707	-1
-Estradiol treatment also increased the arrhythmogenicity of bupivacaine in myocyte cultures, but was only one fourth as potent as progesterone.	progesterone	arrhythmogenicity	1280707	-1
-Non-invasive detection of coronary artery disease by body surface electrocardiographic mapping after dipyridamole infusion.	dipyridamole	coronary artery disease	3746148	-1
-CONCLUSION: The magnitude of the association with PPH, the increase of association with increasing duration of use, and the specificity for fenfluramines are consistent with previous studies indicating that fenfluramines are causally related to PPH.	PPH	PPH	10713017	-1
-CONCLUSION: The magnitude of the association with PPH, the increase of association with increasing duration of use, and the specificity for fenfluramines are consistent with previous studies indicating that fenfluramines are causally related to PPH.	fenfluramines	PPH	10713017	1
-CONCLUSION: The magnitude of the association with PPH, the increase of association with increasing duration of use, and the specificity for fenfluramines are consistent with previous studies indicating that fenfluramines are causally related to PPH.	fenfluramines	PPH	10713017	1
-Acute insulin treatment normalizes the resistance to the cardiotoxic effect of isoproterenol in streptozotocin diabetic rats.	isoproterenol	cardiotoxic	3155884	-1
-Acute insulin treatment normalizes the resistance to the cardiotoxic effect of isoproterenol in streptozotocin diabetic rats.	isoproterenol	diabetic	3155884	-1
-Acute insulin treatment normalizes the resistance to the cardiotoxic effect of isoproterenol in streptozotocin diabetic rats.	streptozotocin	cardiotoxic	3155884	-1
-Acute insulin treatment normalizes the resistance to the cardiotoxic effect of isoproterenol in streptozotocin diabetic rats.	streptozotocin	diabetic	3155884	1
-OBJECTIVE: To assess whether prednisone (PDN) produces anxiety and/or cerebral glial changes in rats.	prednisone	anxiety	11708428	1
-OBJECTIVE: To assess whether prednisone (PDN) produces anxiety and/or cerebral glial changes in rats.	PDN	anxiety	11708428	1
-We studied the prevalence and predictors of levodopa-induced dyskinesia among multiethnic Malaysian patients with PD.	levodopa	PD	23952588	-1
-We studied the prevalence and predictors of levodopa-induced dyskinesia among multiethnic Malaysian patients with PD.	levodopa	dyskinesia	23952588	1
-Tranexamic acid (TNA) 1 g 8-hourly was administered to her to control bleeding per vaginum.	Tranexamic acid	bleeding	24434397	-1
-Tranexamic acid (TNA) 1 g 8-hourly was administered to her to control bleeding per vaginum.	TNA	bleeding	24434397	-1
-Further analysis of these data suggests that the duration of therapy, plasma aminoglycoside levels, liver disease, advanced age, high initial estimated creatinine clearance and, possibly, female gender all increase the risk for nephrotoxicity.	creatinine	liver disease	3538855	-1
-Further analysis of these data suggests that the duration of therapy, plasma aminoglycoside levels, liver disease, advanced age, high initial estimated creatinine clearance and, possibly, female gender all increase the risk for nephrotoxicity.	creatinine	nephrotoxicity	3538855	-1
-Further analysis of these data suggests that the duration of therapy, plasma aminoglycoside levels, liver disease, advanced age, high initial estimated creatinine clearance and, possibly, female gender all increase the risk for nephrotoxicity.	aminoglycoside	liver disease	3538855	-1
-Further analysis of these data suggests that the duration of therapy, plasma aminoglycoside levels, liver disease, advanced age, high initial estimated creatinine clearance and, possibly, female gender all increase the risk for nephrotoxicity.	aminoglycoside	nephrotoxicity	3538855	1
-Neither progesterone nor estradiol effects on bupivacaine arrhythmogenicity were potentiated by epinephrine.	epinephrine	arrhythmogenicity	1280707	-1
-Neither progesterone nor estradiol effects on bupivacaine arrhythmogenicity were potentiated by epinephrine.	bupivacaine	arrhythmogenicity	1280707	-1
-Neither progesterone nor estradiol effects on bupivacaine arrhythmogenicity were potentiated by epinephrine.	estradiol	arrhythmogenicity	1280707	-1
-Neither progesterone nor estradiol effects on bupivacaine arrhythmogenicity were potentiated by epinephrine.	progesterone	arrhythmogenicity	1280707	-1
-At admission simvastatin and all antiviral drugs were discontinued because toxicity due to a drug-drug interaction was suspected.	simvastatin	toxicity	24927617	-1
-A patient with chronic renal failure (CRF) developed neuroleptic malignant syndrome (NMS) after administration of risperidone and levomepromazine.	levomepromazine	neuroleptic malignant syndrome	12452552	1
-A patient with chronic renal failure (CRF) developed neuroleptic malignant syndrome (NMS) after administration of risperidone and levomepromazine.	levomepromazine	NMS	12452552	1
-A patient with chronic renal failure (CRF) developed neuroleptic malignant syndrome (NMS) after administration of risperidone and levomepromazine.	levomepromazine	chronic renal failure	12452552	-1
-A patient with chronic renal failure (CRF) developed neuroleptic malignant syndrome (NMS) after administration of risperidone and levomepromazine.	levomepromazine	CRF	12452552	-1
-A patient with chronic renal failure (CRF) developed neuroleptic malignant syndrome (NMS) after administration of risperidone and levomepromazine.	risperidone	neuroleptic malignant syndrome	12452552	1
-A patient with chronic renal failure (CRF) developed neuroleptic malignant syndrome (NMS) after administration of risperidone and levomepromazine.	risperidone	NMS	12452552	1
-A patient with chronic renal failure (CRF) developed neuroleptic malignant syndrome (NMS) after administration of risperidone and levomepromazine.	risperidone	chronic renal failure	12452552	-1
-A patient with chronic renal failure (CRF) developed neuroleptic malignant syndrome (NMS) after administration of risperidone and levomepromazine.	risperidone	CRF	12452552	-1
-The association between alcohol consumption and depression was significant (p<0.001).	alcohol	depression	20024739	1
-After eliminating spurious hypercalcemias or those associated with intravenous fluids, the authors identified 18 non-lithium-treated patients with hypercalcemias related to malignancies and other medical conditions (group A) and 12 patients with lithium-associated hypercalcemia (group B).	lithium	malignancies	10770468	-1
-After eliminating spurious hypercalcemias or those associated with intravenous fluids, the authors identified 18 non-lithium-treated patients with hypercalcemias related to malignancies and other medical conditions (group A) and 12 patients with lithium-associated hypercalcemia (group B).	lithium	hypercalcemias	10770468	1
-After eliminating spurious hypercalcemias or those associated with intravenous fluids, the authors identified 18 non-lithium-treated patients with hypercalcemias related to malignancies and other medical conditions (group A) and 12 patients with lithium-associated hypercalcemia (group B).	lithium	hypercalcemias	10770468	1
-After eliminating spurious hypercalcemias or those associated with intravenous fluids, the authors identified 18 non-lithium-treated patients with hypercalcemias related to malignancies and other medical conditions (group A) and 12 patients with lithium-associated hypercalcemia (group B).	lithium	malignancies	10770468	-1
-After eliminating spurious hypercalcemias or those associated with intravenous fluids, the authors identified 18 non-lithium-treated patients with hypercalcemias related to malignancies and other medical conditions (group A) and 12 patients with lithium-associated hypercalcemia (group B).	lithium	hypercalcemias	10770468	1
-After eliminating spurious hypercalcemias or those associated with intravenous fluids, the authors identified 18 non-lithium-treated patients with hypercalcemias related to malignancies and other medical conditions (group A) and 12 patients with lithium-associated hypercalcemia (group B).	lithium	hypercalcemias	10770468	1
-After eliminating spurious hypercalcemias or those associated with intravenous fluids, the authors identified 18 non-lithium-treated patients with hypercalcemias related to malignancies and other medical conditions (group A) and 12 patients with lithium-associated hypercalcemia (group B).	lithium	hypercalcemia	10770468	1
-METHODS: The combination of carboplatin (area under the concentration curve [AUC], 5) and liposomal doxorubicin (Doxil; starting dose, 40 mg/m(2)) was administered intravenously every 28 days to 37 patients with recurrent squamous cell cervical carcinoma to determine antitumor activity and toxicity profile.	doxorubicin	squamous cell cervical carcinoma	11745287	-1
-METHODS: The combination of carboplatin (area under the concentration curve [AUC], 5) and liposomal doxorubicin (Doxil; starting dose, 40 mg/m(2)) was administered intravenously every 28 days to 37 patients with recurrent squamous cell cervical carcinoma to determine antitumor activity and toxicity profile.	doxorubicin	toxicity	11745287	-1
-METHODS: The combination of carboplatin (area under the concentration curve [AUC], 5) and liposomal doxorubicin (Doxil; starting dose, 40 mg/m(2)) was administered intravenously every 28 days to 37 patients with recurrent squamous cell cervical carcinoma to determine antitumor activity and toxicity profile.	Doxil	squamous cell cervical carcinoma	11745287	-1
-METHODS: The combination of carboplatin (area under the concentration curve [AUC], 5) and liposomal doxorubicin (Doxil; starting dose, 40 mg/m(2)) was administered intravenously every 28 days to 37 patients with recurrent squamous cell cervical carcinoma to determine antitumor activity and toxicity profile.	Doxil	toxicity	11745287	-1
-METHODS: The combination of carboplatin (area under the concentration curve [AUC], 5) and liposomal doxorubicin (Doxil; starting dose, 40 mg/m(2)) was administered intravenously every 28 days to 37 patients with recurrent squamous cell cervical carcinoma to determine antitumor activity and toxicity profile.	carboplatin	squamous cell cervical carcinoma	11745287	-1
-METHODS: The combination of carboplatin (area under the concentration curve [AUC], 5) and liposomal doxorubicin (Doxil; starting dose, 40 mg/m(2)) was administered intravenously every 28 days to 37 patients with recurrent squamous cell cervical carcinoma to determine antitumor activity and toxicity profile.	carboplatin	toxicity	11745287	-1
-Carvedilol also prevented the decrease in mitochondrial Ca(2+) loading capacity and the inhibition of the respiratory complexes of heart mitochondria caused by doxorubicin.	doxorubicin	heart mitochondria	12498738	-1
-Carvedilol also prevented the decrease in mitochondrial Ca(2+) loading capacity and the inhibition of the respiratory complexes of heart mitochondria caused by doxorubicin.	Carvedilol	heart mitochondria	12498738	-1
-Carvedilol also prevented the decrease in mitochondrial Ca(2+) loading capacity and the inhibition of the respiratory complexes of heart mitochondria caused by doxorubicin.	Ca(2	heart mitochondria	12498738	-1
-Reported cases of decreased dark adaptation are under investigation. Isotretinoin is contraindicated in pregnancy because of the many reported congenital abnormalities after maternal use (including microphthalmos, orbital hypertelorism, and optic nerve hypoplasia).	Isotretinoin	orbital hypertelorism	2931989	-1
-Reported cases of decreased dark adaptation are under investigation. Isotretinoin is contraindicated in pregnancy because of the many reported congenital abnormalities after maternal use (including microphthalmos, orbital hypertelorism, and optic nerve hypoplasia).	Isotretinoin	congenital abnormalities	2931989	-1
-Reported cases of decreased dark adaptation are under investigation. Isotretinoin is contraindicated in pregnancy because of the many reported congenital abnormalities after maternal use (including microphthalmos, orbital hypertelorism, and optic nerve hypoplasia).	Isotretinoin	optic nerve hypoplasia	2931989	-1
-The purpose of the present study was to compare influence of central arginine vasopressin (AVP) and of atrial natriuretic peptide (ANP) on control of arterial blood pressure (MAP) and heart rate (HR) in normotensive (WKY) and spontaneously hypertensive (SHR) rats.	AVP	hypertensive	8188982	1
-BACKGROUND: Acetaminophen-induced hepatotoxicity is the most common cause of acute liver failure (ALF) in the UK.	Acetaminophen	hepatotoxicity	20408947	1
-BACKGROUND: Acetaminophen-induced hepatotoxicity is the most common cause of acute liver failure (ALF) in the UK.	Acetaminophen	acute liver failure	20408947	1
-BACKGROUND: Acetaminophen-induced hepatotoxicity is the most common cause of acute liver failure (ALF) in the UK.	Acetaminophen	ALF	20408947	1
-Seven of the 13 patients had exhibited a subclinical hypertensive state before cyclosporin A therapy.	cyclosporin A	hypertensive	9889429	1
-Studies of synergy between morphine and a novel sodium channel blocker, CNSB002, in rat models of inflammatory and neuropathic pain.	morphine	neuropathic pain	20447294	-1
-Studies of synergy between morphine and a novel sodium channel blocker, CNSB002, in rat models of inflammatory and neuropathic pain.	sodium	neuropathic pain	20447294	-1
-A case of nontraumatic dissecting aneurysm of the basilar artery in association with hypertension, smoke, and oral contraceptives is reported in a young female patient with a locked-in syndrome.	oral contraceptives	hypertension	6884395	-1
-A case of nontraumatic dissecting aneurysm of the basilar artery in association with hypertension, smoke, and oral contraceptives is reported in a young female patient with a locked-in syndrome.	oral contraceptives	aneurysm	6884395	-1
-Chronic progesterone pretreatment (5 mg/kg/day for 21 days) caused a significant increase in bupivacaine arrhythmogenicity in intact pentobarbital-anesthetized rats.	pentobarbital	arrhythmogenicity	1280707	-1
-Chronic progesterone pretreatment (5 mg/kg/day for 21 days) caused a significant increase in bupivacaine arrhythmogenicity in intact pentobarbital-anesthetized rats.	bupivacaine	arrhythmogenicity	1280707	-1
-Chronic progesterone pretreatment (5 mg/kg/day for 21 days) caused a significant increase in bupivacaine arrhythmogenicity in intact pentobarbital-anesthetized rats.	progesterone	arrhythmogenicity	1280707	-1
-Blockade of arrhythmias with both isomers was surmountable by increasing the dose of adrenaline.7.	adrenaline.7	arrhythmias	19108278	1
-He gave a five-year history of polyuria and polydipsia, during which time urinalysis had been negative for glucose.	glucose	polyuria	9538487	-1
-He gave a five-year history of polyuria and polydipsia, during which time urinalysis had been negative for glucose.	glucose	polydipsia	9538487	-1
-A total of 261 adverse ocular reactions occurred in 237 patients who received isotretinoin, a commonly used drug in the treatment of severe cystic acne.	isotretinoin	cystic acne	2931989	-1
-FINDINGS: 85 women met the inclusion criteria for VTE, two of whom were users of progestagen-only OCs.	progestagen	VTE	8996419	-1
-A 54-year-old woman with hyperaldosteronism was treated with verapamil 480 mg/d and spironolactone 100 mg/d.	verapamil	hyperaldosteronism	7949506	-1
-A 54-year-old woman with hyperaldosteronism was treated with verapamil 480 mg/d and spironolactone 100 mg/d.	spironolactone	hyperaldosteronism	7949506	-1
-Coronary blood flow, cardiac work and metabolism were studied in dogs under sodium nitroprusside (SNP) and trimetaphan (TMP) deliberate hypotension (20% and 40% mean pressure decrease from baseline).	sodium nitroprusside	hypotension	6673474	1
-Coronary blood flow, cardiac work and metabolism were studied in dogs under sodium nitroprusside (SNP) and trimetaphan (TMP) deliberate hypotension (20% and 40% mean pressure decrease from baseline).	SNP	hypotension	6673474	1
-Coronary blood flow, cardiac work and metabolism were studied in dogs under sodium nitroprusside (SNP) and trimetaphan (TMP) deliberate hypotension (20% and 40% mean pressure decrease from baseline).	trimetaphan	hypotension	6673474	1
-Coronary blood flow, cardiac work and metabolism were studied in dogs under sodium nitroprusside (SNP) and trimetaphan (TMP) deliberate hypotension (20% and 40% mean pressure decrease from baseline).	TMP	hypotension	6673474	1
-Long-term oral galactose treatment prevents cognitive deficits in male Wistar rats treated intracerebroventricularly with streptozotocin.	streptozotocin	cognitive deficits	24055495	1
-Long-term oral galactose treatment prevents cognitive deficits in male Wistar rats treated intracerebroventricularly with streptozotocin.	galactose	cognitive deficits	24055495	1
-In the preceding months, the patient had a number of admissions with transient unilateral hemiparesis with facial droop, and had been started on valproate for presumed hemiplegic migraine.	valproate	hemiparesis	24614773	-1
-In the preceding months, the patient had a number of admissions with transient unilateral hemiparesis with facial droop, and had been started on valproate for presumed hemiplegic migraine.	valproate	hemiplegic migraine	24614773	-1
-Pupillometric changes while on DEP, especially changes in the total power of pupillary oscillation, were dramatically different than those observed in the eight other study subjects who did not become manic.	DEP	manic	9197951	1
-Pupillometric changes while on DEP, especially changes in the total power of pupillary oscillation, were dramatically different than those observed in the eight other study subjects who did not become manic.	DEP	pupillary oscillation	9197951	-1
-These doses of FZP were lower than those that would alone cause convulsions.	FZP	convulsions	6106951	1
-Four out of 23 consecutive patients treated with high-dose Ara-C for lymphomas in our institution developed a strikingly similar syndrome during the perfusion.	Ara	lymphomas	8318674	-1
-Methyldopa-induced hemolytic anemia in a 15 year old presenting as near-syncope.	Methyldopa	hemolytic anemia	2320485	1
-Methyldopa-induced hemolytic anemia in a 15 year old presenting as near-syncope.	Methyldopa	syncope	2320485	-1
-Methyldopa causes an autoimmune hemolytic anemia in a small percentage of patients who take the drug.	Methyldopa	autoimmune hemolytic anemia	2320485	-1
-Basic and clinical research has demonstrated that dementia of sporadic Alzheimer's disease (sAD) type is associated with dysfunction of the insulin-receptor (IR) system followed by decreased glucose transport via glucose transporter GLUT4 and decreased glucose metabolism in brain cells.	glucose	dementia	24055495	-1
-Basic and clinical research has demonstrated that dementia of sporadic Alzheimer's disease (sAD) type is associated with dysfunction of the insulin-receptor (IR) system followed by decreased glucose transport via glucose transporter GLUT4 and decreased glucose metabolism in brain cells.	glucose	Alzheimer's disease	24055495	1
-Basic and clinical research has demonstrated that dementia of sporadic Alzheimer's disease (sAD) type is associated with dysfunction of the insulin-receptor (IR) system followed by decreased glucose transport via glucose transporter GLUT4 and decreased glucose metabolism in brain cells.	glucose	dementia	24055495	-1
-Basic and clinical research has demonstrated that dementia of sporadic Alzheimer's disease (sAD) type is associated with dysfunction of the insulin-receptor (IR) system followed by decreased glucose transport via glucose transporter GLUT4 and decreased glucose metabolism in brain cells.	glucose	Alzheimer's disease	24055495	1
-Basic and clinical research has demonstrated that dementia of sporadic Alzheimer's disease (sAD) type is associated with dysfunction of the insulin-receptor (IR) system followed by decreased glucose transport via glucose transporter GLUT4 and decreased glucose metabolism in brain cells.	glucose	dementia	24055495	-1
-Basic and clinical research has demonstrated that dementia of sporadic Alzheimer's disease (sAD) type is associated with dysfunction of the insulin-receptor (IR) system followed by decreased glucose transport via glucose transporter GLUT4 and decreased glucose metabolism in brain cells.	glucose	Alzheimer's disease	24055495	1
-Thirteen psoriatic patients with hypertension during the course of cyclosporin A therapy were treated for 25 months with a calcium channel blocker, sustained-release nifedipine, to study the clinical antihypertensive effects and adverse events during treatment with both drugs.	cyclosporin A	hypertension	9889429	1
-Thirteen psoriatic patients with hypertension during the course of cyclosporin A therapy were treated for 25 months with a calcium channel blocker, sustained-release nifedipine, to study the clinical antihypertensive effects and adverse events during treatment with both drugs.	nifedipine	hypertension	9889429	-1
-Thirteen psoriatic patients with hypertension during the course of cyclosporin A therapy were treated for 25 months with a calcium channel blocker, sustained-release nifedipine, to study the clinical antihypertensive effects and adverse events during treatment with both drugs.	calcium	hypertension	9889429	-1
-Isradipine treatment for hypertension in general practice in Hong Kong.	Isradipine	hypertension	1451544	-1
-Misoprostol (200 micrograms) has been shown to acutely counteract the indomethacin-induced renal dysfunction in well compensated cirrhotic patients.	Misoprostol	renal dysfunction	7661171	-1
-Similarly, all adenosine receptor agonists decreased amphetamine-induced hyperactivity, but at the higher doses than those which were active in cocaine-induced hyperactivity.	cocaine	hyperactivity	12523489	-1
-Similarly, all adenosine receptor agonists decreased amphetamine-induced hyperactivity, but at the higher doses than those which were active in cocaine-induced hyperactivity.	cocaine	hyperactivity	12523489	-1
-Similarly, all adenosine receptor agonists decreased amphetamine-induced hyperactivity, but at the higher doses than those which were active in cocaine-induced hyperactivity.	adenosine	hyperactivity	12523489	-1
-Similarly, all adenosine receptor agonists decreased amphetamine-induced hyperactivity, but at the higher doses than those which were active in cocaine-induced hyperactivity.	adenosine	hyperactivity	12523489	-1
-Similarly, all adenosine receptor agonists decreased amphetamine-induced hyperactivity, but at the higher doses than those which were active in cocaine-induced hyperactivity.	amphetamine	hyperactivity	12523489	-1
-Similarly, all adenosine receptor agonists decreased amphetamine-induced hyperactivity, but at the higher doses than those which were active in cocaine-induced hyperactivity.	amphetamine	hyperactivity	12523489	-1
-Ethambutol-induced toxic optic neuropathy was suspected and tablet ethambutol was withdrawn.	Ethambutol	optic neuropathy	24088636	-1
-Ethambutol-induced toxic optic neuropathy was suspected and tablet ethambutol was withdrawn.	ethambutol	optic neuropathy	24088636	-1
-AIMS AND METHODS: We compared the severity of pretransplant illness, psychiatric co-morbidity, medical and psychosocial outcomes of all patients who had undergone liver transplantation (LT) emergently between 1999-2004 for acetaminophen-induced ALF (n=36) with age- and sex-matched patients undergoing emergent LT for non-acetaminophen-induced ALF (n=35) and elective LT for chronic liver disease (CLD, n=34).	acetaminophen	psychiatric	20408947	-1
-AIMS AND METHODS: We compared the severity of pretransplant illness, psychiatric co-morbidity, medical and psychosocial outcomes of all patients who had undergone liver transplantation (LT) emergently between 1999-2004 for acetaminophen-induced ALF (n=36) with age- and sex-matched patients undergoing emergent LT for non-acetaminophen-induced ALF (n=35) and elective LT for chronic liver disease (CLD, n=34).	acetaminophen	ALF	20408947	1
-AIMS AND METHODS: We compared the severity of pretransplant illness, psychiatric co-morbidity, medical and psychosocial outcomes of all patients who had undergone liver transplantation (LT) emergently between 1999-2004 for acetaminophen-induced ALF (n=36) with age- and sex-matched patients undergoing emergent LT for non-acetaminophen-induced ALF (n=35) and elective LT for chronic liver disease (CLD, n=34).	acetaminophen	chronic liver disease	20408947	-1
-AIMS AND METHODS: We compared the severity of pretransplant illness, psychiatric co-morbidity, medical and psychosocial outcomes of all patients who had undergone liver transplantation (LT) emergently between 1999-2004 for acetaminophen-induced ALF (n=36) with age- and sex-matched patients undergoing emergent LT for non-acetaminophen-induced ALF (n=35) and elective LT for chronic liver disease (CLD, n=34).	acetaminophen	CLD	20408947	-1
-AIMS AND METHODS: We compared the severity of pretransplant illness, psychiatric co-morbidity, medical and psychosocial outcomes of all patients who had undergone liver transplantation (LT) emergently between 1999-2004 for acetaminophen-induced ALF (n=36) with age- and sex-matched patients undergoing emergent LT for non-acetaminophen-induced ALF (n=35) and elective LT for chronic liver disease (CLD, n=34).	acetaminophen	psychiatric	20408947	-1
-AIMS AND METHODS: We compared the severity of pretransplant illness, psychiatric co-morbidity, medical and psychosocial outcomes of all patients who had undergone liver transplantation (LT) emergently between 1999-2004 for acetaminophen-induced ALF (n=36) with age- and sex-matched patients undergoing emergent LT for non-acetaminophen-induced ALF (n=35) and elective LT for chronic liver disease (CLD, n=34).	acetaminophen	ALF	20408947	1
-AIMS AND METHODS: We compared the severity of pretransplant illness, psychiatric co-morbidity, medical and psychosocial outcomes of all patients who had undergone liver transplantation (LT) emergently between 1999-2004 for acetaminophen-induced ALF (n=36) with age- and sex-matched patients undergoing emergent LT for non-acetaminophen-induced ALF (n=35) and elective LT for chronic liver disease (CLD, n=34).	acetaminophen	ALF	20408947	1
-AIMS AND METHODS: We compared the severity of pretransplant illness, psychiatric co-morbidity, medical and psychosocial outcomes of all patients who had undergone liver transplantation (LT) emergently between 1999-2004 for acetaminophen-induced ALF (n=36) with age- and sex-matched patients undergoing emergent LT for non-acetaminophen-induced ALF (n=35) and elective LT for chronic liver disease (CLD, n=34).	acetaminophen	chronic liver disease	20408947	-1
-AIMS AND METHODS: We compared the severity of pretransplant illness, psychiatric co-morbidity, medical and psychosocial outcomes of all patients who had undergone liver transplantation (LT) emergently between 1999-2004 for acetaminophen-induced ALF (n=36) with age- and sex-matched patients undergoing emergent LT for non-acetaminophen-induced ALF (n=35) and elective LT for chronic liver disease (CLD, n=34).	acetaminophen	CLD	20408947	-1
-The plasticity of primary motor cortex (M1) in patients with Parkinson's disease (PD) and levodopa-induced dyskinesias (LIDs) is severely impaired.	levodopa	Parkinson's disease	23535177	-1
-The plasticity of primary motor cortex (M1) in patients with Parkinson's disease (PD) and levodopa-induced dyskinesias (LIDs) is severely impaired.	levodopa	PD	23535177	-1
-The plasticity of primary motor cortex (M1) in patients with Parkinson's disease (PD) and levodopa-induced dyskinesias (LIDs) is severely impaired.	levodopa	dyskinesias	23535177	1
-The plasticity of primary motor cortex (M1) in patients with Parkinson's disease (PD) and levodopa-induced dyskinesias (LIDs) is severely impaired.	levodopa	LIDs	23535177	1
-Carboplatin did not appear to add to the hematologic toxicities observed, and the paclitaxel/carboplatin combination could be dosed every 3 weeks.	paclitaxel	toxicities	7644931	-1
-Carboplatin did not appear to add to the hematologic toxicities observed, and the paclitaxel/carboplatin combination could be dosed every 3 weeks.	Carboplatin	toxicities	7644931	-1
-Carboplatin did not appear to add to the hematologic toxicities observed, and the paclitaxel/carboplatin combination could be dosed every 3 weeks.	carboplatin	toxicities	7644931	-1
-METHOD: Case-based observations from a medical intensive care unit (MICU) in a tertiary care facility in a 27-year-old female with FHF from acetaminophen and resultant cerebral edema.	acetaminophen	cerebral edema	19728177	1
-METHOD: Case-based observations from a medical intensive care unit (MICU) in a tertiary care facility in a 27-year-old female with FHF from acetaminophen and resultant cerebral edema.	acetaminophen	FHF	19728177	-1
-GEM-P chemotherapy is active in the treatment of relapsed Hodgkin lymphoma.	GEM	Hodgkin lymphoma	24158386	-1
-Data were collected on adult cancer patients receiving single-agent cisplatin as an outpatient from January 2011 to September 2012.	cisplatin	cancer	24778426	-1
-Both the precordial pain and the electrocardiographic changes disappeared spontaneously after the discontinuation of 5-FU.	5-FU	pain	16369751	-1
-Incubation with NS-718 resulted in significantly less damage of cultured human renal proximal tubular epithelial cells compared with D-AmB. Serum blood urea and creatinine concentrations increased significantly in rats given an iv infusion of D-AmB 3 mg/kg but not in those given the same dose of NS-718.	D-AmB.	NS-718	10933650	-1
-Incubation with NS-718 resulted in significantly less damage of cultured human renal proximal tubular epithelial cells compared with D-AmB. Serum blood urea and creatinine concentrations increased significantly in rats given an iv infusion of D-AmB 3 mg/kg but not in those given the same dose of NS-718.	D-AmB.	NS-718	10933650	-1
-Incubation with NS-718 resulted in significantly less damage of cultured human renal proximal tubular epithelial cells compared with D-AmB. Serum blood urea and creatinine concentrations increased significantly in rats given an iv infusion of D-AmB 3 mg/kg but not in those given the same dose of NS-718.	D-AmB	NS-718	10933650	-1
-Incubation with NS-718 resulted in significantly less damage of cultured human renal proximal tubular epithelial cells compared with D-AmB. Serum blood urea and creatinine concentrations increased significantly in rats given an iv infusion of D-AmB 3 mg/kg but not in those given the same dose of NS-718.	D-AmB	NS-718	10933650	-1
-Incubation with NS-718 resulted in significantly less damage of cultured human renal proximal tubular epithelial cells compared with D-AmB. Serum blood urea and creatinine concentrations increased significantly in rats given an iv infusion of D-AmB 3 mg/kg but not in those given the same dose of NS-718.	creatinine	NS-718	10933650	-1
-Incubation with NS-718 resulted in significantly less damage of cultured human renal proximal tubular epithelial cells compared with D-AmB. Serum blood urea and creatinine concentrations increased significantly in rats given an iv infusion of D-AmB 3 mg/kg but not in those given the same dose of NS-718.	creatinine	NS-718	10933650	-1
-Incubation with NS-718 resulted in significantly less damage of cultured human renal proximal tubular epithelial cells compared with D-AmB. Serum blood urea and creatinine concentrations increased significantly in rats given an iv infusion of D-AmB 3 mg/kg but not in those given the same dose of NS-718.	urea	NS-718	10933650	-1
-Incubation with NS-718 resulted in significantly less damage of cultured human renal proximal tubular epithelial cells compared with D-AmB. Serum blood urea and creatinine concentrations increased significantly in rats given an iv infusion of D-AmB 3 mg/kg but not in those given the same dose of NS-718.	urea	NS-718	10933650	-1
-As the precordial pain in this patient was considered to have been due to 5-FU-induced cardiotoxicity, the administration of 5-FU was abandoned.	5-FU	pain	16369751	-1
-As the precordial pain in this patient was considered to have been due to 5-FU-induced cardiotoxicity, the administration of 5-FU was abandoned.	5-FU	cardiotoxicity	16369751	-1
-As the precordial pain in this patient was considered to have been due to 5-FU-induced cardiotoxicity, the administration of 5-FU was abandoned.	5-FU	pain	16369751	-1
-As the precordial pain in this patient was considered to have been due to 5-FU-induced cardiotoxicity, the administration of 5-FU was abandoned.	5-FU	cardiotoxicity	16369751	-1
-We report three cases of severe hypoxaemia after ibuprofen administration during a randomised controlled trial of prophylactic treatment of patent ductus arteriosus with ibuprofen in premature infants born at less than 28 weeks of gestation.	ibuprofen	patent ductus arteriosus	11988250	-1
-We report three cases of severe hypoxaemia after ibuprofen administration during a randomised controlled trial of prophylactic treatment of patent ductus arteriosus with ibuprofen in premature infants born at less than 28 weeks of gestation.	ibuprofen	hypoxaemia	11988250	1
-We report three cases of severe hypoxaemia after ibuprofen administration during a randomised controlled trial of prophylactic treatment of patent ductus arteriosus with ibuprofen in premature infants born at less than 28 weeks of gestation.	ibuprofen	patent ductus arteriosus	11988250	-1
-Histopathological examination of the kidney showed tubular necrosis in D-AmB-treated rats but no change in NS-718-treated rats.	D-AmB	NS-718-treated	10933650	-1
-Histopathological examination of the kidney showed tubular necrosis in D-AmB-treated rats but no change in NS-718-treated rats.	D-AmB	necrosis	10933650	-1
-A morphometric study of isoproterenol induced myocardial fibrosis.	isoproterenol	myocardial fibrosis	3155884	-1
-Bepridil, a novel active compound for prophylactic treatment of anginal attacks, induced persistent bradycardia and a non-specific anti-tachycardial effect, the mechanisms of which were investigated in vitro and in vivo.	Bepridil	anginal attacks	6985297	-1
-Bepridil, a novel active compound for prophylactic treatment of anginal attacks, induced persistent bradycardia and a non-specific anti-tachycardial effect, the mechanisms of which were investigated in vitro and in vivo.	Bepridil	bradycardia	6985297	1
-Persistent sterile leukocyturia was frequently associated with a mild increase in the urine albumin/creatinine ratio and by microscopic hematuria.	creatinine	hematuria	12165618	-1
-Persistent sterile leukocyturia was frequently associated with a mild increase in the urine albumin/creatinine ratio and by microscopic hematuria.	creatinine	sterile leukocyturia	12165618	-1
-The authors report on six cases of famotidine-associated delirium in hospitalized patients who cleared completely upon removal of famotidine.	famotidine	delirium	8701013	1
-The authors report on six cases of famotidine-associated delirium in hospitalized patients who cleared completely upon removal of famotidine.	famotidine	delirium	8701013	1
-The experience of this case, together with a review of the literature, suggests that FBAL is related to 5-FU-induced cardiotoxicity.	5-FU	cardiotoxicity	16369751	-1
-The experience of this case, together with a review of the literature, suggests that FBAL is related to 5-FU-induced cardiotoxicity.	FBAL	cardiotoxicity	16369751	-1
-S-1 may be administered safely to patients with 5-FU-induced cardiotoxicity.	5-FU	cardiotoxicity	16369751	-1
-Neither the type of induction agent (Althesin or Thiopentone) nor the salt preparation of suxamethonium used (chloride or bromide), affected the incidence of scoline pain.	Thiopentone	pain	7176945	-1
-Neither the type of induction agent (Althesin or Thiopentone) nor the salt preparation of suxamethonium used (chloride or bromide), affected the incidence of scoline pain.	suxamethonium	pain	7176945	1
-Neither the type of induction agent (Althesin or Thiopentone) nor the salt preparation of suxamethonium used (chloride or bromide), affected the incidence of scoline pain.	bromide	pain	7176945	-1
-Neither the type of induction agent (Althesin or Thiopentone) nor the salt preparation of suxamethonium used (chloride or bromide), affected the incidence of scoline pain.	chloride	pain	7176945	-1
-Children with persistent sterile leukocyturia more frequently had serum creatinine levels of 50% above normal than those children without persistent sterile leukocyturia.	creatinine	sterile leukocyturia	12165618	-1
-Children with persistent sterile leukocyturia more frequently had serum creatinine levels of 50% above normal than those children without persistent sterile leukocyturia.	creatinine	sterile leukocyturia	12165618	-1
-Hypoxaemia resolved quickly on inhaled nitric oxide therapy.	nitric oxide	Hypoxaemia	11988250	-1
-Patterns of sulfadiazine acute nephrotoxicity.	sulfadiazine	nephrotoxicity	10939760	-1
-It is postulated that this action may have been enhanced during halothane anaesthesia with resultant bradycardia and hypotension.	halothane	hypotension	6615679	-1
-It is postulated that this action may have been enhanced during halothane anaesthesia with resultant bradycardia and hypotension.	halothane	bradycardia	6615679	-1
-Sulfadiazine acute nephrotoxicity is reviving specially because of its use in toxoplasmosis in HIV-positive patients.	Sulfadiazine	nephrotoxicity	10939760	-1
-Improved familiarity of healthcare professionals with argatroban therapy in HIT, including in special populations and during PCI, may facilitate reduction of harm associated with HIT (e.g. fewer thromboses) or its treatment (e.g. fewer argatroban medication errors).	argatroban	HIT	19338378	-1
-Improved familiarity of healthcare professionals with argatroban therapy in HIT, including in special populations and during PCI, may facilitate reduction of harm associated with HIT (e.g. fewer thromboses) or its treatment (e.g. fewer argatroban medication errors).	argatroban	HIT	19338378	-1
-Improved familiarity of healthcare professionals with argatroban therapy in HIT, including in special populations and during PCI, may facilitate reduction of harm associated with HIT (e.g. fewer thromboses) or its treatment (e.g. fewer argatroban medication errors).	argatroban	thromboses	19338378	-1
-Improved familiarity of healthcare professionals with argatroban therapy in HIT, including in special populations and during PCI, may facilitate reduction of harm associated with HIT (e.g. fewer thromboses) or its treatment (e.g. fewer argatroban medication errors).	argatroban	HIT	19338378	-1
-Improved familiarity of healthcare professionals with argatroban therapy in HIT, including in special populations and during PCI, may facilitate reduction of harm associated with HIT (e.g. fewer thromboses) or its treatment (e.g. fewer argatroban medication errors).	argatroban	HIT	19338378	-1
-Improved familiarity of healthcare professionals with argatroban therapy in HIT, including in special populations and during PCI, may facilitate reduction of harm associated with HIT (e.g. fewer thromboses) or its treatment (e.g. fewer argatroban medication errors).	argatroban	thromboses	19338378	-1
-The authors describe the case of a 56-year-old woman with chronic, severe heart failure secondary to dilated cardiomyopathy and absence of significant ventricular arrhythmias who developed QT prolongation and torsade de pointes ventricular tachycardia during one cycle of intermittent low dose (2.5 mcg/kg per min) dobutamine.	dobutamine	ventricular arrhythmias	10087562	-1
-The authors describe the case of a 56-year-old woman with chronic, severe heart failure secondary to dilated cardiomyopathy and absence of significant ventricular arrhythmias who developed QT prolongation and torsade de pointes ventricular tachycardia during one cycle of intermittent low dose (2.5 mcg/kg per min) dobutamine.	dobutamine	dilated cardiomyopathy	10087562	-1
-The authors describe the case of a 56-year-old woman with chronic, severe heart failure secondary to dilated cardiomyopathy and absence of significant ventricular arrhythmias who developed QT prolongation and torsade de pointes ventricular tachycardia during one cycle of intermittent low dose (2.5 mcg/kg per min) dobutamine.	dobutamine	ventricular tachycardia	10087562	-1
-The authors describe the case of a 56-year-old woman with chronic, severe heart failure secondary to dilated cardiomyopathy and absence of significant ventricular arrhythmias who developed QT prolongation and torsade de pointes ventricular tachycardia during one cycle of intermittent low dose (2.5 mcg/kg per min) dobutamine.	dobutamine	QT prolongation	10087562	-1
-The authors describe the case of a 56-year-old woman with chronic, severe heart failure secondary to dilated cardiomyopathy and absence of significant ventricular arrhythmias who developed QT prolongation and torsade de pointes ventricular tachycardia during one cycle of intermittent low dose (2.5 mcg/kg per min) dobutamine.	dobutamine	heart failure	10087562	-1
-We compared the effects of single doses of 50 mg atenolol (cardioselective), 40 mg propranolol (nonselective), and placebo on both exercise- and isoproterenol-induced tachycardia in two experiments involving nine normal subjects.	atenolol	tachycardia	6299641	-1
-We compared the effects of single doses of 50 mg atenolol (cardioselective), 40 mg propranolol (nonselective), and placebo on both exercise- and isoproterenol-induced tachycardia in two experiments involving nine normal subjects.	propranolol	tachycardia	6299641	-1
-Use of argatroban and catheter-directed thrombolysis with alteplase in an oncology patient with heparin-induced thrombocytopenia with thrombosis.	heparin	thrombocytopenia	24733133	1
-Use of argatroban and catheter-directed thrombolysis with alteplase in an oncology patient with heparin-induced thrombocytopenia with thrombosis.	heparin	thrombosis	24733133	-1
-Use of argatroban and catheter-directed thrombolysis with alteplase in an oncology patient with heparin-induced thrombocytopenia with thrombosis.	argatroban	thrombocytopenia	24733133	-1
-Use of argatroban and catheter-directed thrombolysis with alteplase in an oncology patient with heparin-induced thrombocytopenia with thrombosis.	argatroban	thrombosis	24733133	-1
-This report of torsade de pointes ventricular tachycardia during intermittent dobutamine supports the hypothesis that unpredictable fatal arrhythmias may occur even with low doses and in patients with no history of significant rhythm disturbances.	dobutamine	arrhythmias	10087562	-1
-This report of torsade de pointes ventricular tachycardia during intermittent dobutamine supports the hypothesis that unpredictable fatal arrhythmias may occur even with low doses and in patients with no history of significant rhythm disturbances.	dobutamine	rhythm disturbances	10087562	-1
-This report of torsade de pointes ventricular tachycardia during intermittent dobutamine supports the hypothesis that unpredictable fatal arrhythmias may occur even with low doses and in patients with no history of significant rhythm disturbances.	dobutamine	torsade de pointes	10087562	1
-This report of torsade de pointes ventricular tachycardia during intermittent dobutamine supports the hypothesis that unpredictable fatal arrhythmias may occur even with low doses and in patients with no history of significant rhythm disturbances.	dobutamine	ventricular tachycardia	10087562	-1
-AIM: To study the effects of testosterone on streptozotocin (STZ)-induced memory impairment in male rats.	testosterone	memory impairment	24902786	-1
-AIM: To study the effects of testosterone on streptozotocin (STZ)-induced memory impairment in male rats.	streptozotocin	memory impairment	24902786	1
-AIM: To study the effects of testosterone on streptozotocin (STZ)-induced memory impairment in male rats.	STZ)-induced	memory impairment	24902786	1
-Under treatment with sulfadiazine they developed oliguria, abdominal pain, renal failure and showed multiple radiolucent renal calculi in echography.	sulfadiazine	oliguria	10939760	-1
-Under treatment with sulfadiazine they developed oliguria, abdominal pain, renal failure and showed multiple radiolucent renal calculi in echography.	sulfadiazine	abdominal pain	10939760	-1
-Under treatment with sulfadiazine they developed oliguria, abdominal pain, renal failure and showed multiple radiolucent renal calculi in echography.	sulfadiazine	renal failure	10939760	-1
-Children with persistent sterile leukocyturia more frequently had an increase in serum creatinine levels of >50% above normal.	creatinine	sterile leukocyturia	12165618	-1
-A transient tonic pupillary response, denervation supersensitivity, and abnormal visual-evoked potentials in quinine toxicity, to our knowledge, have not been previously reported.	quinine	toxicity	7369302	-1
-Regarding the effects of drug-induced hypotension on coronary blood flow, aortic and coronary sinus metabolic data (pH, pO2, pCO2) we could confirm that nitroprusside hypotension could be safely used to 30% mean blood pressure decrease from control, trimetaphan hypotension to 20% mean blood pressure decrease.	nitroprusside	hypotension	6673474	1
-Regarding the effects of drug-induced hypotension on coronary blood flow, aortic and coronary sinus metabolic data (pH, pO2, pCO2) we could confirm that nitroprusside hypotension could be safely used to 30% mean blood pressure decrease from control, trimetaphan hypotension to 20% mean blood pressure decrease.	nitroprusside	hypotension	6673474	1
-Bilateral visual field constriction was observed in 59% of patients currently taking VGB, 43% of patients who previously took VGB, and 24% of patients with no exposure to VGB.	VGB	Bilateral visual field constriction	19815465	1
-Bilateral visual field constriction was observed in 59% of patients currently taking VGB, 43% of patients who previously took VGB, and 24% of patients with no exposure to VGB.	VGB	Bilateral visual field constriction	19815465	1
-Bilateral visual field constriction was observed in 59% of patients currently taking VGB, 43% of patients who previously took VGB, and 24% of patients with no exposure to VGB.	VGB	Bilateral visual field constriction	19815465	1
-This first case of meloxicam related liver toxicity demonstrates the potential of this drug to induce hepatic damage.	meloxicam	toxicity	10427794	-1
-Antioxidant effects of bovine lactoferrin on dexamethasone-induced hypertension in rat.	dexamethasone	hypertension	24587916	1
-Antioxidant effects of bovine lactoferrin on dexamethasone-induced hypertension in rat.	bovine lactoferrin	hypertension	24587916	-1
-Six stable psychiatric outpatients with hyperprolactinemia and amenorrhea/oligomenorrhea associated with their neuroleptic medications were treated with bromocriptine.	bromocriptine	psychiatric	1359137	-1
-Six stable psychiatric outpatients with hyperprolactinemia and amenorrhea/oligomenorrhea associated with their neuroleptic medications were treated with bromocriptine.	bromocriptine	hyperprolactinemia	1359137	-1
-Six stable psychiatric outpatients with hyperprolactinemia and amenorrhea/oligomenorrhea associated with their neuroleptic medications were treated with bromocriptine.	bromocriptine	oligomenorrhea	1359137	-1
-Six stable psychiatric outpatients with hyperprolactinemia and amenorrhea/oligomenorrhea associated with their neuroleptic medications were treated with bromocriptine.	bromocriptine	amenorrhea	1359137	-1
-Because toxicity may occur when flecainide is prescribed with paroxetine and other potent CYP2D6 inhibitors, flecainide plasma concentrations should be monitored closely with commencement of CYP2D6 inhibitors.	paroxetine	toxicity	19531695	-1
-Because toxicity may occur when flecainide is prescribed with paroxetine and other potent CYP2D6 inhibitors, flecainide plasma concentrations should be monitored closely with commencement of CYP2D6 inhibitors.	flecainide	toxicity	19531695	-1
-Because toxicity may occur when flecainide is prescribed with paroxetine and other potent CYP2D6 inhibitors, flecainide plasma concentrations should be monitored closely with commencement of CYP2D6 inhibitors.	flecainide	toxicity	19531695	-1
-LF lowered (P < 0.01) and dose dependently prevented (P < 0.001) Dex-induced hypertension.	Dex	hypertension	24587916	1
-LF lowered (P < 0.01) and dose dependently prevented (P < 0.001) Dex-induced hypertension.	Dex	LF	24587916	-1
-Indinavir-associated nephrotoxicity must be monitored closely, especially in children with risk factors such as persistent sterile leukocyturia, age <5.6 years, an area under the curve of indinavir >19 mg/L x h, and a C(max) >12 mg/L.	Indinavir	sterile leukocyturia	12165618	-1
-Indinavir-associated nephrotoxicity must be monitored closely, especially in children with risk factors such as persistent sterile leukocyturia, age <5.6 years, an area under the curve of indinavir >19 mg/L x h, and a C(max) >12 mg/L.	indinavir	sterile leukocyturia	12165618	-1
-Mechanisms for protective effects of free radical scavengers on gentamicin-mediated nephropathy in rats.	gentamicin	nephropathy	8160791	1
-The patient experienced relapsing MSSA bacteremia on day 9, increasing the suspicion for a central nervous system (CNS) infection.	MSSA	infection	20959502	-1
-The patient experienced relapsing MSSA bacteremia on day 9, increasing the suspicion for a central nervous system (CNS) infection.	MSSA	bacteremia	20959502	-1
-CONCLUSIONS: Children treated with indinavir have a high cumulative incidence of persistent sterile leukocyturia.	indinavir	sterile leukocyturia	12165618	-1
-We suggest that investigators involved in similar trials pay close attention to pulmonary pressure if hypoxaemia occurs after prophylactic administration of ibuprofen.	ibuprofen	pulmonary pressure if hypoxaemia	11988250	-1
-Troponin I levels positively correlated with delayed and peak gadolinium contrast enhancement, histopathological grading, and diastolic dysfunction.	gadolinium	diastolic dysfunction	24675088	-1
-The results showed that aconitine resulted in myocardial injury and reduced NRVMs viability dose-dependently.	aconitine	myocardial injury	24840785	-1
-An investigation of the pattern of kidney injury in HIV-positive persons exposed to tenofovir disoproxil fumarate: an examination of a large population database (MHRA database).	tenofovir disoproxil fumarate	kidney injury	24067251	-1
-Renal patients on cyclosporine had the fewest bacteremias.	cyclosporine	bacteremias	6310832	-1
-Ifosfamide related encephalopathy: the need for a timely EEG evaluation.	Ifosfamide	encephalopathy	24209900	-1
-Large doses of the cholinomimetic, pilocarpine, could induce catalepsy when peripheral cholinergic receptors were blocked.	pilocarpine	catalepsy	3925479	1
-However, until this apparent ability of 200 micrograms of misoprostol to prevent the adverse effects of indomethacin on renal function is confirmed with chronic frequent dosing, it would be prudent to avoid nonsteroidal anti-inflammatory therapy in patients with cirrhosis.	misoprostol	cirrhosis	7661171	-1
-However, until this apparent ability of 200 micrograms of misoprostol to prevent the adverse effects of indomethacin on renal function is confirmed with chronic frequent dosing, it would be prudent to avoid nonsteroidal anti-inflammatory therapy in patients with cirrhosis.	indomethacin	cirrhosis	7661171	-1
-BACKGROUND: Osteoporosis is caused by bone resorption in excess of bone formation, and bisphosphonates, are used to inhibit bone resorption.	bisphosphonates	Osteoporosis	20927253	-1
-Downbeat nystagmus associated with intravenous patient-controlled administration of morphine.	morphine	nystagmus	10960401	1
-The side effects of azathioprine include anemia, which has been attributed to bone marrow suppression.	azathioprine	anemia	18340638	1
-The present results demonstrate that CCK-8 attenuates the effect of morphine on hippocampal LTP through CCK2 receptors and suggest an ameliorative function of CCK-8 on morphine-induced memory impairment.	CCK-8	memory impairment	24309294	-1
-The present results demonstrate that CCK-8 attenuates the effect of morphine on hippocampal LTP through CCK2 receptors and suggest an ameliorative function of CCK-8 on morphine-induced memory impairment.	CCK-8	memory impairment	24309294	-1
-The present results demonstrate that CCK-8 attenuates the effect of morphine on hippocampal LTP through CCK2 receptors and suggest an ameliorative function of CCK-8 on morphine-induced memory impairment.	morphine	memory impairment	24309294	-1
-The present results demonstrate that CCK-8 attenuates the effect of morphine on hippocampal LTP through CCK2 receptors and suggest an ameliorative function of CCK-8 on morphine-induced memory impairment.	morphine	memory impairment	24309294	-1
-Reversal of scopolamine-induced amnesia of passive avoidance by pre- and post-training naloxone.	naloxone	amnesia	3088653	-1
-Chronic pre-treatment with metformin reduces post-myocardial infarction cardiac dysfunction and suppresses inflammatory responses, possibly through inhibition of TLR4 activities.	metformin	myocardial infarction	24842192	-1
-Chronic pre-treatment with metformin reduces post-myocardial infarction cardiac dysfunction and suppresses inflammatory responses, possibly through inhibition of TLR4 activities.	metformin	cardiac dysfunction	24842192	-1
-The acute effect of insulin treatment on the earlier reported protective effect of streptozotocin diabetes against the cardiotoxic effect of high doses of isoproterenol (ISO) was investigated in rats.	streptozotocin	cardiotoxic	3155884	-1
-The acute effect of insulin treatment on the earlier reported protective effect of streptozotocin diabetes against the cardiotoxic effect of high doses of isoproterenol (ISO) was investigated in rats.	isoproterenol	cardiotoxic	3155884	-1
-The acute effect of insulin treatment on the earlier reported protective effect of streptozotocin diabetes against the cardiotoxic effect of high doses of isoproterenol (ISO) was investigated in rats.	isoproterenol	diabetes	3155884	-1
-The acute effect of insulin treatment on the earlier reported protective effect of streptozotocin diabetes against the cardiotoxic effect of high doses of isoproterenol (ISO) was investigated in rats.	ISO	cardiotoxic	3155884	-1
-The acute effect of insulin treatment on the earlier reported protective effect of streptozotocin diabetes against the cardiotoxic effect of high doses of isoproterenol (ISO) was investigated in rats.	ISO	diabetes	3155884	-1
-Physicians should recognise the possibility of fatal bacterial infections related to bortezomib plus high-dose dexamethasone in elderly patients, and we believe this case warrants further investigation.	bortezomib	infections	24671324	-1
-Physicians should recognise the possibility of fatal bacterial infections related to bortezomib plus high-dose dexamethasone in elderly patients, and we believe this case warrants further investigation.	dexamethasone	infections	24671324	-1
-Rifampicin-associated segmental necrotizing glomerulonephritis in staphylococcal endocarditis.	Rifampicin	staphylococcal endocarditis	17879217	-1
-A 27-yr-old man developed jaundice 2 wk after exposure to thiabendazole.	thiabendazole	jaundice	3297909	-1
-Segmental necrotising glomerulonephritis has been reported as complication of rifampicin therapy in patients receiving treatment for tuberculosis.	rifampicin	Segmental necrotising glomerulonephritis	17879217	-1
-Segmental necrotising glomerulonephritis has been reported as complication of rifampicin therapy in patients receiving treatment for tuberculosis.	rifampicin	tuberculosis	17879217	-1
-Renal function was assessed by biochemical (plasma urea and creatinine), functional (urine analysis and [3H]inulin and [14C]p-aminohippuric acid clearances) and morphological (degree of necrosis) indices.	creatinine	necrosis	2907577	-1
-Renal function was assessed by biochemical (plasma urea and creatinine), functional (urine analysis and [3H]inulin and [14C]p-aminohippuric acid clearances) and morphological (degree of necrosis) indices.	urea	necrosis	2907577	-1
-Renal function was assessed by biochemical (plasma urea and creatinine), functional (urine analysis and [3H]inulin and [14C]p-aminohippuric acid clearances) and morphological (degree of necrosis) indices.	14C]p-aminohippuric acid	necrosis	2907577	-1
-Changing epidemiology of infections such as infective endocarditis (IE) has led to an increase in the use of rifampicin for Staphylococcal infections.	rifampicin	infections	17879217	-1
-Changing epidemiology of infections such as infective endocarditis (IE) has led to an increase in the use of rifampicin for Staphylococcal infections.	rifampicin	infective endocarditis	17879217	-1
-Changing epidemiology of infections such as infective endocarditis (IE) has led to an increase in the use of rifampicin for Staphylococcal infections.	rifampicin	IE	17879217	-1
-Changing epidemiology of infections such as infective endocarditis (IE) has led to an increase in the use of rifampicin for Staphylococcal infections.	rifampicin	Staphylococcal infections	17879217	-1
-METHODS AND RESULTS: In 20 patients (14 men and 6 women aged 39 to 72 years) referred for cardiac catheterization for the evaluation of chest pain, we measured heart rate, systemic arterial pressure, LV pressure and its first derivative (dP/dt), and LV volumes and ejection fraction before and during the final 2 to 3 minutes of a 15-minute intracoronary infusion of saline (n=10, control subjects) or cocaine hydrochloride 1 mg/min (n=10).	cocaine hydrochloride	LV	9570197	1
-METHODS AND RESULTS: In 20 patients (14 men and 6 women aged 39 to 72 years) referred for cardiac catheterization for the evaluation of chest pain, we measured heart rate, systemic arterial pressure, LV pressure and its first derivative (dP/dt), and LV volumes and ejection fraction before and during the final 2 to 3 minutes of a 15-minute intracoronary infusion of saline (n=10, control subjects) or cocaine hydrochloride 1 mg/min (n=10).	cocaine hydrochloride	LV	9570197	1
-METHODS AND RESULTS: In 20 patients (14 men and 6 women aged 39 to 72 years) referred for cardiac catheterization for the evaluation of chest pain, we measured heart rate, systemic arterial pressure, LV pressure and its first derivative (dP/dt), and LV volumes and ejection fraction before and during the final 2 to 3 minutes of a 15-minute intracoronary infusion of saline (n=10, control subjects) or cocaine hydrochloride 1 mg/min (n=10).	cocaine hydrochloride	chest pain	9570197	-1
-Quantitative, real-time polymerase chain reaction also demonstrated significant increases (P < or = 0.01) in p75(NTR) mRNA in DRG with intermediate and chronic CYP-induced cystitis.	CYP	cystitis	18189308	1
-Effect of alkylxanthines on gentamicin-induced acute renal failure in the rat.	gentamicin	acute renal failure	2907577	1
-Two cases of deliberate self-poisoning with 5 g and 3.6 g of amisulpride, respectively, are reported.	amisulpride	poisoning	15953230	-1
-Administration of aprotinin should be avoided in coronary artery bypass graft and high risk patients, whereas administration of tranexamic acid is not recommended in valve surgery.	tranexamic acid	coronary artery	19020118	-1
-Spontaneous pain behaviors following the administration of CYP were observed.	CYP	pain	23666265	1
-Carbimazole induced ANCA positive vasculitis.	Carbimazole	vasculitis	19263707	-1
-From 1986 to 1998, 29 cancer patients who had 32 episodes of transient hyperammonemic encephalopathy related to continuous infusion of 5-fluorouracil (5-FU) were identified.	5-fluorouracil	cancer	10327032	-1
-From 1986 to 1998, 29 cancer patients who had 32 episodes of transient hyperammonemic encephalopathy related to continuous infusion of 5-fluorouracil (5-FU) were identified.	5-fluorouracil	hyperammonemic encephalopathy	10327032	1
-From 1986 to 1998, 29 cancer patients who had 32 episodes of transient hyperammonemic encephalopathy related to continuous infusion of 5-fluorouracil (5-FU) were identified.	5-FU	cancer	10327032	-1
-Results from our behavioral phenotyping indicated that anxiety-like behavior was increased in mice exposed to BPA.	BPA	anxiety	23871786	1
-Present study clearly suggests that glial activation and post synaptic neurotoxicity are the key factors in STZ induced memory impairment and neuronal cell death.	STZ	memory impairment	24333387	1
-Present study clearly suggests that glial activation and post synaptic neurotoxicity are the key factors in STZ induced memory impairment and neuronal cell death.	STZ	synaptic neurotoxicity	24333387	-1
-Present study clearly suggests that glial activation and post synaptic neurotoxicity are the key factors in STZ induced memory impairment and neuronal cell death.	STZ	death	24333387	-1
-AChE activity was significantly decreased in the hippocampus of mice with BPA compared to control mice, whereas no difference was found in the prefrontal cortex, hypothalamus and cerebellum.	BPA	hypothalamus	23871786	-1
-Nifedipine induced bradycardia in a patient with autonomic neuropathy.	Nifedipine	autonomic neuropathy	2614930	-1
-Cardiac work was significantly reduced during SNP hypotension.	SNP	hypotension	6673474	1
-Famotidine-associated delirium.	Famotidine	delirium	8701013	1
-Gemcitabine and cisplatin have activity in HL, non-overlapping toxicity with first-line chemotherapeutics, and may be delivered in an outpatient setting.	Gemcitabine	toxicity	24158386	-1
-Gemcitabine and cisplatin have activity in HL, non-overlapping toxicity with first-line chemotherapeutics, and may be delivered in an outpatient setting.	Gemcitabine	HL	24158386	-1
-Gemcitabine and cisplatin have activity in HL, non-overlapping toxicity with first-line chemotherapeutics, and may be delivered in an outpatient setting.	cisplatin	toxicity	24158386	-1
-Gemcitabine and cisplatin have activity in HL, non-overlapping toxicity with first-line chemotherapeutics, and may be delivered in an outpatient setting.	cisplatin	HL	24158386	-1
-The purpose of this study was to determine if PAP formation is a requisite step in APAP-induced nephrotoxicity.	PAP	nephrotoxicity	4082192	-1
-The purpose of this study was to determine if PAP formation is a requisite step in APAP-induced nephrotoxicity.	APAP	nephrotoxicity	4082192	-1
-Capsaicin injection was reproducible for secondary hyperalgesia (ICC > 0.70) and allodynia (ICC > 0.71).	Capsaicin	hyperalgesia	24684312	1
-Higher plasma ammonium levels and more rapid onset of hyperammonemia were seen in 18 patients with bacterial infections (p=0.003 and 0.0006, respectively) and in nine patients receiving high daily doses (2600 or 1800 mg/m2) of 5-FU (p=0.0001 and < 0.0001, respectively).	5-FU	hyperammonemia	10327032	1
-Higher plasma ammonium levels and more rapid onset of hyperammonemia were seen in 18 patients with bacterial infections (p=0.003 and 0.0006, respectively) and in nine patients receiving high daily doses (2600 or 1800 mg/m2) of 5-FU (p=0.0001 and < 0.0001, respectively).	5-FU	infections	10327032	-1
-Higher plasma ammonium levels and more rapid onset of hyperammonemia were seen in 18 patients with bacterial infections (p=0.003 and 0.0006, respectively) and in nine patients receiving high daily doses (2600 or 1800 mg/m2) of 5-FU (p=0.0001 and < 0.0001, respectively).	ammonium	hyperammonemia	10327032	-1
-Higher plasma ammonium levels and more rapid onset of hyperammonemia were seen in 18 patients with bacterial infections (p=0.003 and 0.0006, respectively) and in nine patients receiving high daily doses (2600 or 1800 mg/m2) of 5-FU (p=0.0001 and < 0.0001, respectively).	ammonium	infections	10327032	-1
-We conclude that the CYA cardiotoxicity correlates with CYA dosage as calculated by body surface area, and that patients with aplastic anemia and immunodeficiencies can be effectively prepared for bone marrow grafting at a CYA dose of 1.55 g/m2/d for four days with a lower incidence of cardiotoxicity than patients whose CYA dosage is calculated based on weight.	CYA	aplastic anemia	3533179	-1
-We conclude that the CYA cardiotoxicity correlates with CYA dosage as calculated by body surface area, and that patients with aplastic anemia and immunodeficiencies can be effectively prepared for bone marrow grafting at a CYA dose of 1.55 g/m2/d for four days with a lower incidence of cardiotoxicity than patients whose CYA dosage is calculated based on weight.	CYA	cardiotoxicity	3533179	-1
-We conclude that the CYA cardiotoxicity correlates with CYA dosage as calculated by body surface area, and that patients with aplastic anemia and immunodeficiencies can be effectively prepared for bone marrow grafting at a CYA dose of 1.55 g/m2/d for four days with a lower incidence of cardiotoxicity than patients whose CYA dosage is calculated based on weight.	CYA	cardiotoxicity	3533179	-1
-We conclude that the CYA cardiotoxicity correlates with CYA dosage as calculated by body surface area, and that patients with aplastic anemia and immunodeficiencies can be effectively prepared for bone marrow grafting at a CYA dose of 1.55 g/m2/d for four days with a lower incidence of cardiotoxicity than patients whose CYA dosage is calculated based on weight.	CYA	immunodeficiencies	3533179	-1
-We conclude that the CYA cardiotoxicity correlates with CYA dosage as calculated by body surface area, and that patients with aplastic anemia and immunodeficiencies can be effectively prepared for bone marrow grafting at a CYA dose of 1.55 g/m2/d for four days with a lower incidence of cardiotoxicity than patients whose CYA dosage is calculated based on weight.	CYA	aplastic anemia	3533179	-1
-We conclude that the CYA cardiotoxicity correlates with CYA dosage as calculated by body surface area, and that patients with aplastic anemia and immunodeficiencies can be effectively prepared for bone marrow grafting at a CYA dose of 1.55 g/m2/d for four days with a lower incidence of cardiotoxicity than patients whose CYA dosage is calculated based on weight.	CYA	cardiotoxicity	3533179	-1
-We conclude that the CYA cardiotoxicity correlates with CYA dosage as calculated by body surface area, and that patients with aplastic anemia and immunodeficiencies can be effectively prepared for bone marrow grafting at a CYA dose of 1.55 g/m2/d for four days with a lower incidence of cardiotoxicity than patients whose CYA dosage is calculated based on weight.	CYA	cardiotoxicity	3533179	-1
-We conclude that the CYA cardiotoxicity correlates with CYA dosage as calculated by body surface area, and that patients with aplastic anemia and immunodeficiencies can be effectively prepared for bone marrow grafting at a CYA dose of 1.55 g/m2/d for four days with a lower incidence of cardiotoxicity than patients whose CYA dosage is calculated based on weight.	CYA	immunodeficiencies	3533179	-1
-We conclude that the CYA cardiotoxicity correlates with CYA dosage as calculated by body surface area, and that patients with aplastic anemia and immunodeficiencies can be effectively prepared for bone marrow grafting at a CYA dose of 1.55 g/m2/d for four days with a lower incidence of cardiotoxicity than patients whose CYA dosage is calculated based on weight.	CYA	aplastic anemia	3533179	-1
-We conclude that the CYA cardiotoxicity correlates with CYA dosage as calculated by body surface area, and that patients with aplastic anemia and immunodeficiencies can be effectively prepared for bone marrow grafting at a CYA dose of 1.55 g/m2/d for four days with a lower incidence of cardiotoxicity than patients whose CYA dosage is calculated based on weight.	CYA	cardiotoxicity	3533179	-1
-We conclude that the CYA cardiotoxicity correlates with CYA dosage as calculated by body surface area, and that patients with aplastic anemia and immunodeficiencies can be effectively prepared for bone marrow grafting at a CYA dose of 1.55 g/m2/d for four days with a lower incidence of cardiotoxicity than patients whose CYA dosage is calculated based on weight.	CYA	cardiotoxicity	3533179	-1
-We conclude that the CYA cardiotoxicity correlates with CYA dosage as calculated by body surface area, and that patients with aplastic anemia and immunodeficiencies can be effectively prepared for bone marrow grafting at a CYA dose of 1.55 g/m2/d for four days with a lower incidence of cardiotoxicity than patients whose CYA dosage is calculated based on weight.	CYA	immunodeficiencies	3533179	-1
-We conclude that the CYA cardiotoxicity correlates with CYA dosage as calculated by body surface area, and that patients with aplastic anemia and immunodeficiencies can be effectively prepared for bone marrow grafting at a CYA dose of 1.55 g/m2/d for four days with a lower incidence of cardiotoxicity than patients whose CYA dosage is calculated based on weight.	CYA	aplastic anemia	3533179	-1
-We conclude that the CYA cardiotoxicity correlates with CYA dosage as calculated by body surface area, and that patients with aplastic anemia and immunodeficiencies can be effectively prepared for bone marrow grafting at a CYA dose of 1.55 g/m2/d for four days with a lower incidence of cardiotoxicity than patients whose CYA dosage is calculated based on weight.	CYA	cardiotoxicity	3533179	-1
-We conclude that the CYA cardiotoxicity correlates with CYA dosage as calculated by body surface area, and that patients with aplastic anemia and immunodeficiencies can be effectively prepared for bone marrow grafting at a CYA dose of 1.55 g/m2/d for four days with a lower incidence of cardiotoxicity than patients whose CYA dosage is calculated based on weight.	CYA	cardiotoxicity	3533179	-1
-We conclude that the CYA cardiotoxicity correlates with CYA dosage as calculated by body surface area, and that patients with aplastic anemia and immunodeficiencies can be effectively prepared for bone marrow grafting at a CYA dose of 1.55 g/m2/d for four days with a lower incidence of cardiotoxicity than patients whose CYA dosage is calculated based on weight.	CYA	immunodeficiencies	3533179	-1
-Intravascular hemolysis and acute renal failure following intermittent rifampin therapy.	rifampin	acute renal failure	1522360	1
-Although the ability of cyclophosphamide to cause hemorrhagic cystitis and urine cytologic abnormalities indistinguishable from high grade carcinoma is well known, it is less widely appreciated that it is also associated with carcinoma of the urinary tract.	cyclophosphamide	hemorrhagic cystitis	7248895	-1
-Ethacrynic acid-induced convulsions and brain neurotransmitters in mice.	Ethacrynic acid	convulsions	1360900	1
-Widespread cognitive disorders, such as delirium, have not been previously linked with high blood levels of SSRIs.	SSRIs	delirium	8312983	-1
-Widespread cognitive disorders, such as delirium, have not been previously linked with high blood levels of SSRIs.	SSRIs	cognitive disorders	8312983	-1
-Chronic treatment with metformin suppresses toll-like receptor 4 signaling and attenuates left ventricular dysfunction following myocardial infarction.	metformin	left ventricular dysfunction	24842192	-1
-Chronic treatment with metformin suppresses toll-like receptor 4 signaling and attenuates left ventricular dysfunction following myocardial infarction.	metformin	myocardial infarction	24842192	-1
-In conclusion, hyperammonemic encephalopathy can occur in patients receiving continuous infusion of 5-FU.	5-FU	hyperammonemic encephalopathy	10327032	1
-PURPOSE: To compare the susceptibility to nephrotoxic effect of CM in patients undergoing PTRA with that of patients submitted to percutaneous coronary intervention (PCI).	PTRA	nephrotoxic	20192893	-1
-The present studies examine the expression and regulation of another receptor known to bind NGF, p75(NTR), after various durations of bladder inflammation induced by cyclophosphamide (CYP).	cyclophosphamide	bladder inflammation	18189308	-1
-The present studies examine the expression and regulation of another receptor known to bind NGF, p75(NTR), after various durations of bladder inflammation induced by cyclophosphamide (CYP).	CYP	bladder inflammation	18189308	-1
-The aim of the present study was to investigate the protective effect of the Solidago virgaurea extract on isoproterenol-induced cardiotoxicity in rats.	Solidago virgaurea extract	cardiotoxicity	23872883	-1
-It is concluded that PAP formation, in vivo, accounts, at least in part, for APAP-induced renal tubular necrosis.	PAP	renal tubular necrosis	4082192	1
-Intracerebroventricular injection of ethacrynic acid (50% convulsive dose; 50 micrograms/mouse) accelerated the synthesis/turnover of 5-hydroxytryptamine (5-HT) but suppressed the synthesis of gamma-aminobutyric acid and acetylcholine in mouse brain.	gamma-aminobutyric acid	convulsive	1360900	-1
-Intracerebroventricular injection of ethacrynic acid (50% convulsive dose; 50 micrograms/mouse) accelerated the synthesis/turnover of 5-hydroxytryptamine (5-HT) but suppressed the synthesis of gamma-aminobutyric acid and acetylcholine in mouse brain.	acetylcholine	convulsive	1360900	-1
-Intracerebroventricular injection of ethacrynic acid (50% convulsive dose; 50 micrograms/mouse) accelerated the synthesis/turnover of 5-hydroxytryptamine (5-HT) but suppressed the synthesis of gamma-aminobutyric acid and acetylcholine in mouse brain.	ethacrynic acid	convulsive	1360900	1
-Intracerebroventricular injection of ethacrynic acid (50% convulsive dose; 50 micrograms/mouse) accelerated the synthesis/turnover of 5-hydroxytryptamine (5-HT) but suppressed the synthesis of gamma-aminobutyric acid and acetylcholine in mouse brain.	5-hydroxytryptamine	convulsive	1360900	-1
-Intracerebroventricular injection of ethacrynic acid (50% convulsive dose; 50 micrograms/mouse) accelerated the synthesis/turnover of 5-hydroxytryptamine (5-HT) but suppressed the synthesis of gamma-aminobutyric acid and acetylcholine in mouse brain.	5-HT	convulsive	1360900	-1
-Thus, our data suggest that the kinin B2 receptor is involved in cisplatin-induced acute kidney injury by mediating the necrotic process and the expression of inflammatory cytokines, thus resulting in declined renal function.	cisplatin	acute kidney injury	24975837	1
-Thus, our data suggest that the kinin B2 receptor is involved in cisplatin-induced acute kidney injury by mediating the necrotic process and the expression of inflammatory cytokines, thus resulting in declined renal function.	cisplatin	necrotic	24975837	-1
-The present study was designed to investigate whether nociceptin/orphanin FQ and nocistatin could modulate impairment of learning and memory induced by scopolamine, a muscarinic cholinergic receptor antagonist, using spontaneous alternation of Y-maze and step-down type passive avoidance tasks in mice.	nocistatin	impairment of learning and memory	10401555	-1
-The present study was designed to investigate whether nociceptin/orphanin FQ and nocistatin could modulate impairment of learning and memory induced by scopolamine, a muscarinic cholinergic receptor antagonist, using spontaneous alternation of Y-maze and step-down type passive avoidance tasks in mice.	nociceptin	impairment of learning and memory	10401555	-1
-The present study was designed to investigate whether nociceptin/orphanin FQ and nocistatin could modulate impairment of learning and memory induced by scopolamine, a muscarinic cholinergic receptor antagonist, using spontaneous alternation of Y-maze and step-down type passive avoidance tasks in mice.	orphanin FQ	impairment of learning and memory	10401555	-1
-The present study was designed to investigate whether nociceptin/orphanin FQ and nocistatin could modulate impairment of learning and memory induced by scopolamine, a muscarinic cholinergic receptor antagonist, using spontaneous alternation of Y-maze and step-down type passive avoidance tasks in mice.	scopolamine	impairment of learning and memory	10401555	1
-To best of our knowledge this is the second case of fatal carbamazepine induced myocarditis reported in English literature.	carbamazepine	myocarditis	20129423	1
-CYP-induced cystitis increased (P < or = 0.001) p75(NTR) expression in the superficial lateral and medial dorsal horn in L1-L2 and L6-S1 spinal segments.	CYP	cystitis	18189308	1
-RESULTS: We evaluated 143 patients who received single-agent cisplatin; 97.2% of patients had head and neck cancer as their primary malignancy.	cisplatin	malignancy	24778426	-1
-RESULTS: We evaluated 143 patients who received single-agent cisplatin; 97.2% of patients had head and neck cancer as their primary malignancy.	cisplatin	neck cancer	24778426	-1
-These side effects are relatively rare in a given individual, but given the extremely widespread use of heparin, some are quite common, particularly HITT and osteoporosis.	heparin	osteoporosis	10726030	1
-Bradycardia occurred in a 45-year-old male patient who was Viracept in combination with other anti-HIV drugs.	Viracept	Bradycardia	11366874	1
-Oral administration of betaine (200 and 400 mg/kg) significantly reduced the level of cardiac marker enzyme in the serum and prevented left ventricular remodeling.	betaine	ventricular remodeling	25080425	-1
-Thirty to 135 min after the injection of crystalline insulin, ISO was given subcutaneously and when ISO induced fibrosis in the myocardium was morphometrically analyzed 7 days later, a highly significant correlation (r = 0.83, 2 p = 0.006) to the slope of the fall in blood glucose after insulin treatment appeared.	ISO	fibrosis	3155884	1
-Thirty to 135 min after the injection of crystalline insulin, ISO was given subcutaneously and when ISO induced fibrosis in the myocardium was morphometrically analyzed 7 days later, a highly significant correlation (r = 0.83, 2 p = 0.006) to the slope of the fall in blood glucose after insulin treatment appeared.	glucose	fibrosis	3155884	-1
-The chronic feeding of small amounts (0.3-3% of diet weight) of certain amino derivatives of caproate resulted in hyperglycemia, an elevated glucose tolerance curve and, occasionally, glucosuria.	glucose	glucosuria	1117341	-1
-The chronic feeding of small amounts (0.3-3% of diet weight) of certain amino derivatives of caproate resulted in hyperglycemia, an elevated glucose tolerance curve and, occasionally, glucosuria.	glucose	hyperglycemia	1117341	-1
-The chronic feeding of small amounts (0.3-3% of diet weight) of certain amino derivatives of caproate resulted in hyperglycemia, an elevated glucose tolerance curve and, occasionally, glucosuria.	caproate	glucosuria	1117341	-1
-The chronic feeding of small amounts (0.3-3% of diet weight) of certain amino derivatives of caproate resulted in hyperglycemia, an elevated glucose tolerance curve and, occasionally, glucosuria.	caproate	hyperglycemia	1117341	-1
-Pre-treatment with a dose of 30 mg/kg 2h before picrotoxin microperfusion prevented seizures in the 75% of the rats.	picrotoxin	seizures	16920333	1
-Thrombotic complications in acute promyelocytic leukemia during all-trans-retinoic acid therapy.	all-trans-retinoic acid	acute promyelocytic leukemia	9158667	-1
-Thrombotic complications in acute promyelocytic leukemia during all-trans-retinoic acid therapy.	all-trans-retinoic acid	Thrombotic complications	9158667	1
-The number of p75(NTR)-immunoreactive (-IR) cells in the lumbosacral dorsal root ganglia (DRG) also increased (P < or = 0.05) with CYP-induced cystitis (acute, intermediate, and chronic).	CYP	cystitis	18189308	1
-CONCLUSION: Olanzapine demonstrated greater efficacy than placebo in the treatment of acute bipolar mania and was generally well tolerated.	Olanzapine	bipolar mania	10986547	-1
-infusion of clonazepam; none had any neurological symptoms.	clonazepam	neurological symptoms	2400986	-1
-There was a direct relationship between CHP concentration and patients' ratings of pain on an analogue scale.	CHP	pain	2383364	1
-The possible aetiologies of valproate-induced encephalopathy and NMDA receptor-associated encephalitis present a diagnostic dilemma.	valproate	encephalopathy	24614773	-1
-The possible aetiologies of valproate-induced encephalopathy and NMDA receptor-associated encephalitis present a diagnostic dilemma.	valproate	encephalitis	24614773	-1
-Risk factors and predictors of levodopa-induced dyskinesia among multiethnic Malaysians with Parkinson's disease.	levodopa	Parkinson's disease	23952588	-1
-Resuscitation with lipid, epinephrine, or both in levobupivacaine-induced cardiac toxicity in newborn piglets.	levobupivacaine	cardiac toxicity	24091473	-1
-Resuscitation with lipid, epinephrine, or both in levobupivacaine-induced cardiac toxicity in newborn piglets.	epinephrine	cardiac toxicity	24091473	-1
-Lamivudine is a novel 2',3'-dideoxy cytosine analogue that has potent inhibitory effects on hepatitis B virus replication in vitro and in vivo.	Lamivudine	hepatitis B	8985298	-1
-Lamivudine is a novel 2',3'-dideoxy cytosine analogue that has potent inhibitory effects on hepatitis B virus replication in vitro and in vivo.	2',3'-dideoxy cytosine	hepatitis B	8985298	-1
-A case of branch retinal vein occlusion associated with fluoxetine-induced secondary hypertension is described.	fluoxetine	hypertension	18025637	1
-This study shows that busulfan neurotoxicity is dose-dependent in children and efficiently prevented by clonazepam.	busulfan	neurotoxicity	2400986	-1
-This study shows that busulfan neurotoxicity is dose-dependent in children and efficiently prevented by clonazepam.	clonazepam	neurotoxicity	2400986	-1
-Adenosine antagonists have been previously shown to be of benefit in some ischaemic and nephrotoxic models of acute renal failure (ARF).	Adenosine	acute renal failure	2907577	-1
-Adenosine antagonists have been previously shown to be of benefit in some ischaemic and nephrotoxic models of acute renal failure (ARF).	Adenosine	ARF	2907577	-1
-Adenosine antagonists have been previously shown to be of benefit in some ischaemic and nephrotoxic models of acute renal failure (ARF).	Adenosine	ischaemic and nephrotoxic	2907577	-1
-Quetiapine-induced neutropenia in a bipolar patient with hepatocellular carcinoma.	Quetiapine	bipolar	25084821	-1
-Quetiapine-induced neutropenia in a bipolar patient with hepatocellular carcinoma.	Quetiapine	hepatocellular carcinoma	25084821	-1
-Quetiapine-induced neutropenia in a bipolar patient with hepatocellular carcinoma.	Quetiapine	neutropenia	25084821	1
-A busulfan dose calculated on the basis of body surface area, resulting in higher doses in young children, was followed by increased neurotoxicity, close to neurotoxicity incidence observed in adults.	busulfan	neurotoxicity	2400986	-1
-A busulfan dose calculated on the basis of body surface area, resulting in higher doses in young children, was followed by increased neurotoxicity, close to neurotoxicity incidence observed in adults.	busulfan	neurotoxicity	2400986	-1
-Intraperitoneal administration of cholecystokinin octapeptide sulphate ester (CCK-8-SE) and nonsulphated cholecystokinin octapeptide (CCK-8-NS) enhanced the latency of seizures induced by picrotoxin in mice.	cholecystokinin octapeptide sulphate ester	seizures	6316193	-1
-Intraperitoneal administration of cholecystokinin octapeptide sulphate ester (CCK-8-SE) and nonsulphated cholecystokinin octapeptide (CCK-8-NS) enhanced the latency of seizures induced by picrotoxin in mice.	CCK-8-SE	seizures	6316193	-1
-Intraperitoneal administration of cholecystokinin octapeptide sulphate ester (CCK-8-SE) and nonsulphated cholecystokinin octapeptide (CCK-8-NS) enhanced the latency of seizures induced by picrotoxin in mice.	cholecystokinin octapeptide	seizures	6316193	-1
-Intraperitoneal administration of cholecystokinin octapeptide sulphate ester (CCK-8-SE) and nonsulphated cholecystokinin octapeptide (CCK-8-NS) enhanced the latency of seizures induced by picrotoxin in mice.	CCK-8-NS	seizures	6316193	-1
-This suggestion of an association between metolachlor and liver cancer among pesticide applicators is a novel finding and echoes observation of increased liver neoplasms in some animal studies.	metolachlor	liver cancer	26033014	-1
-The 0.25 per cent CHP cream was closest to AgSD in pain tolerance; however, none of the treatments differed statistically from AgSD or from each other.	AgSD	pain	2383364	-1
-The 0.25 per cent CHP cream was closest to AgSD in pain tolerance; however, none of the treatments differed statistically from AgSD or from each other.	AgSD	pain	2383364	-1
-Hydroxytyrosol ameliorates oxidative stress and mitochondrial dysfunction in doxorubicin-induced cardiotoxicity in rats with breast cancer.	doxorubicin	cardiotoxicity	24727461	-1
-Hydroxytyrosol ameliorates oxidative stress and mitochondrial dysfunction in doxorubicin-induced cardiotoxicity in rats with breast cancer.	doxorubicin	mitochondrial dysfunction	24727461	-1
-Hydroxytyrosol ameliorates oxidative stress and mitochondrial dysfunction in doxorubicin-induced cardiotoxicity in rats with breast cancer.	doxorubicin	breast cancer	24727461	-1
-Hydroxytyrosol ameliorates oxidative stress and mitochondrial dysfunction in doxorubicin-induced cardiotoxicity in rats with breast cancer.	Hydroxytyrosol	cardiotoxicity	24727461	-1
-Hydroxytyrosol ameliorates oxidative stress and mitochondrial dysfunction in doxorubicin-induced cardiotoxicity in rats with breast cancer.	Hydroxytyrosol	mitochondrial dysfunction	24727461	-1
-Hydroxytyrosol ameliorates oxidative stress and mitochondrial dysfunction in doxorubicin-induced cardiotoxicity in rats with breast cancer.	Hydroxytyrosol	breast cancer	24727461	-1
-Induction of apoptosis by remoxipride metabolites in HL60 and CD34+/CD19- human bone marrow progenitor cells: potential relevance to remoxipride-induced aplastic anemia.	remoxipride	aplastic anemia	10462057	1
-Comparison of the effect of oxitropium bromide and of slow-release theophylline on nocturnal asthma.	theophylline	nocturnal asthma	3074291	-1
-Comparison of the effect of oxitropium bromide and of slow-release theophylline on nocturnal asthma.	oxitropium bromide	nocturnal asthma	3074291	-1
-Cerebellar and oculomotor dysfunction induced by rapid infusion of pethidine.	pethidine	oculomotor dysfunction	24618873	-1
-Levodopa is the most effective symptomatic therapy for Parkinson's disease, but its chronic use could lead to chronic adverse outcomes, such as motor fluctuations, dyskinesia and visual hallucinations.	Levodopa	Parkinson's disease	24126708	-1
-Levodopa is the most effective symptomatic therapy for Parkinson's disease, but its chronic use could lead to chronic adverse outcomes, such as motor fluctuations, dyskinesia and visual hallucinations.	Levodopa	dyskinesia	24126708	1
-Levodopa is the most effective symptomatic therapy for Parkinson's disease, but its chronic use could lead to chronic adverse outcomes, such as motor fluctuations, dyskinesia and visual hallucinations.	Levodopa	visual hallucinations	24126708	1
-Pethidine is an opioid that gains its popularity for the effective pain control through acting on the opioid-receptors.	Pethidine	pain	24618873	-1
-Indications for transplantation were idiopathic cardiomyopathy (52%), congenital heart disease (35%) with and without prior repair (71% and 29%, respectively), hypertrophic cardiomyopathy (5%), valvular heart disease (3%), and doxorubicin cardiomyopathy (5%).	doxorubicin	idiopathic cardiomyopathy	8312343	-1
-Indications for transplantation were idiopathic cardiomyopathy (52%), congenital heart disease (35%) with and without prior repair (71% and 29%, respectively), hypertrophic cardiomyopathy (5%), valvular heart disease (3%), and doxorubicin cardiomyopathy (5%).	doxorubicin	cardiomyopathy	8312343	1
-Indications for transplantation were idiopathic cardiomyopathy (52%), congenital heart disease (35%) with and without prior repair (71% and 29%, respectively), hypertrophic cardiomyopathy (5%), valvular heart disease (3%), and doxorubicin cardiomyopathy (5%).	doxorubicin	congenital heart disease	8312343	-1
-Indications for transplantation were idiopathic cardiomyopathy (52%), congenital heart disease (35%) with and without prior repair (71% and 29%, respectively), hypertrophic cardiomyopathy (5%), valvular heart disease (3%), and doxorubicin cardiomyopathy (5%).	doxorubicin	hypertrophic cardiomyopathy	8312343	-1
-Indications for transplantation were idiopathic cardiomyopathy (52%), congenital heart disease (35%) with and without prior repair (71% and 29%, respectively), hypertrophic cardiomyopathy (5%), valvular heart disease (3%), and doxorubicin cardiomyopathy (5%).	doxorubicin	valvular heart disease	8312343	-1
-One woman, however, developed worsened psychiatric symptoms while taking bromocriptine, and it was discontinued.	bromocriptine	psychiatric	1359137	-1
-In this retrospective single-centre analysis, patients with relapsed or refractory HL treated with gemcitabine 1,000 mg/m(2) day (D)1, D8 and D15; methylprednisolone 1,000 mg D1-5; and cisplatin 100	methylprednisolone	HL	24158386	-1
-In this retrospective single-centre analysis, patients with relapsed or refractory HL treated with gemcitabine 1,000 mg/m(2) day (D)1, D8 and D15; methylprednisolone 1,000 mg D1-5; and cisplatin 100	gemcitabine	HL	24158386	-1
-In this retrospective single-centre analysis, patients with relapsed or refractory HL treated with gemcitabine 1,000 mg/m(2) day (D)1, D8 and D15; methylprednisolone 1,000 mg D1-5; and cisplatin 100	cisplatin	HL	24158386	-1
-In normal rats with intact kidneys, rhIGF-I administration (n = 4) did not alter weight gain, blood pressure, proteinuria, GFR, glomerular planar area, renal cortical malondialdehyde content, or glomerular or tubulointerstitial damage, compared with untreated animals (n = 4).	malondialdehyde	weight gain	8825380	-1
-In normal rats with intact kidneys, rhIGF-I administration (n = 4) did not alter weight gain, blood pressure, proteinuria, GFR, glomerular planar area, renal cortical malondialdehyde content, or glomerular or tubulointerstitial damage, compared with untreated animals (n = 4).	malondialdehyde	proteinuria	8825380	-1
-The incidence and intensity of muscle fasciculations caused by suxamethonium were significantly greater in the control than in the alfentanil group.	alfentanil	muscle fasciculations	3125850	-1
-In patients with impaired renal and liver function, and those who need long-term pain control, pethidine may cause excitatory central nervous system (CNS) effects through its neurotoxic metabolite, norpethidine, resulting in irritability and seizure attack.	norpethidine	irritability	24618873	-1
-In patients with impaired renal and liver function, and those who need long-term pain control, pethidine may cause excitatory central nervous system (CNS) effects through its neurotoxic metabolite, norpethidine, resulting in irritability and seizure attack.	norpethidine	pain	24618873	-1
-In patients with impaired renal and liver function, and those who need long-term pain control, pethidine may cause excitatory central nervous system (CNS) effects through its neurotoxic metabolite, norpethidine, resulting in irritability and seizure attack.	norpethidine	seizure	24618873	1
-In patients with impaired renal and liver function, and those who need long-term pain control, pethidine may cause excitatory central nervous system (CNS) effects through its neurotoxic metabolite, norpethidine, resulting in irritability and seizure attack.	norpethidine	neurotoxic	24618873	-1
-In patients with impaired renal and liver function, and those who need long-term pain control, pethidine may cause excitatory central nervous system (CNS) effects through its neurotoxic metabolite, norpethidine, resulting in irritability and seizure attack.	norpethidine	impaired renal and liver function	24618873	-1
-In patients with impaired renal and liver function, and those who need long-term pain control, pethidine may cause excitatory central nervous system (CNS) effects through its neurotoxic metabolite, norpethidine, resulting in irritability and seizure attack.	pethidine	irritability	24618873	-1
-In patients with impaired renal and liver function, and those who need long-term pain control, pethidine may cause excitatory central nervous system (CNS) effects through its neurotoxic metabolite, norpethidine, resulting in irritability and seizure attack.	pethidine	pain	24618873	-1
-In patients with impaired renal and liver function, and those who need long-term pain control, pethidine may cause excitatory central nervous system (CNS) effects through its neurotoxic metabolite, norpethidine, resulting in irritability and seizure attack.	pethidine	seizure	24618873	-1
-In patients with impaired renal and liver function, and those who need long-term pain control, pethidine may cause excitatory central nervous system (CNS) effects through its neurotoxic metabolite, norpethidine, resulting in irritability and seizure attack.	pethidine	neurotoxic	24618873	-1
-In patients with impaired renal and liver function, and those who need long-term pain control, pethidine may cause excitatory central nervous system (CNS) effects through its neurotoxic metabolite, norpethidine, resulting in irritability and seizure attack.	pethidine	impaired renal and liver function	24618873	-1
-Efficacy and safety of granisetron, a selective 5-hydroxytryptamine-3 receptor antagonist, in the prevention of nausea and vomiting induced by high-dose cisplatin.	cisplatin	nausea	7931490	1
-Efficacy and safety of granisetron, a selective 5-hydroxytryptamine-3 receptor antagonist, in the prevention of nausea and vomiting induced by high-dose cisplatin.	cisplatin	vomiting	7931490	1
-Efficacy and safety of granisetron, a selective 5-hydroxytryptamine-3 receptor antagonist, in the prevention of nausea and vomiting induced by high-dose cisplatin.	5-hydroxytryptamine-3	nausea	7931490	-1
-Efficacy and safety of granisetron, a selective 5-hydroxytryptamine-3 receptor antagonist, in the prevention of nausea and vomiting induced by high-dose cisplatin.	5-hydroxytryptamine-3	vomiting	7931490	-1
-The antipsychotic agent, remoxipride [(S)-(-)-3-bromo-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2,6-dimethoxybenz amide] has been associated with acquired aplastic anemia.	remoxipride [(S)-(-)-3-bromo-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2,6-dimethoxybenz amide	aplastic anemia	10462057	1
-Major azotemia (serum creatinine greater than 2.5 mg/dl or BUN greater than 50 mg/dl) occurred in only 2%.	creatinine	azotemia	256433	-1
-Bortezomib and dexamethasone as salvage therapy in patients with relapsed/refractory multiple myeloma: analysis of long-term clinical outcomes	Bortezomib	myeloma	23864035	-1
-Bortezomib and dexamethasone as salvage therapy in patients with relapsed/refractory multiple myeloma: analysis of long-term clinical outcomes	dexamethasone	myeloma	23864035	-1
-A significant reduction in urinary guanosine 3',5'-cyclic monophosphate (cGMP) excretion and a significant increase in renal cortical renin and endothelin-1 contents were also observed in GM-mediated nephropathy.	GM	nephropathy	8160791	1
-A significant reduction in urinary guanosine 3',5'-cyclic monophosphate (cGMP) excretion and a significant increase in renal cortical renin and endothelin-1 contents were also observed in GM-mediated nephropathy.	guanosine 3',5'-cyclic monophosphate	nephropathy	8160791	-1
-Structure-activity and dose-effect relationships of the antagonism of picrotoxin-induced seizures by cholecystokinin, fragments and analogues of cholecystokinin in mice.	picrotoxin	seizures	6316193	1
-The adverse events during combined therapy with cyclosporin A and nifedipine included an increase in blood urea nitrogen levels in 9 of the 13 patients and development of gingival hyperplasia in 2 of the 13 patients.	cyclosporin A	gingival hyperplasia	9889429	1
-The adverse events during combined therapy with cyclosporin A and nifedipine included an increase in blood urea nitrogen levels in 9 of the 13 patients and development of gingival hyperplasia in 2 of the 13 patients.	nifedipine	gingival hyperplasia	9889429	1
-Bortezomib and high-dose dexamethasone-containing regimens are considered to be generally tolerable with few severe bacterial infections in patients with B-cell malignancies.	Bortezomib	infections	24671324	-1
-Bortezomib and high-dose dexamethasone-containing regimens are considered to be generally tolerable with few severe bacterial infections in patients with B-cell malignancies.	Bortezomib	malignancies	24671324	-1
-Bortezomib and high-dose dexamethasone-containing regimens are considered to be generally tolerable with few severe bacterial infections in patients with B-cell malignancies.	dexamethasone	infections	24671324	-1
-Bortezomib and high-dose dexamethasone-containing regimens are considered to be generally tolerable with few severe bacterial infections in patients with B-cell malignancies.	dexamethasone	malignancies	24671324	-1
-Phenylpropanolamine (PPA) overdose can cause severe hypertension, intracerebral hemorrhage, and death.	Phenylpropanolamine	hypertension	3987172	1
-Phenylpropanolamine (PPA) overdose can cause severe hypertension, intracerebral hemorrhage, and death.	Phenylpropanolamine	overdose	3987172	-1
-Phenylpropanolamine (PPA) overdose can cause severe hypertension, intracerebral hemorrhage, and death.	Phenylpropanolamine	death	3987172	-1
-Phenylpropanolamine (PPA) overdose can cause severe hypertension, intracerebral hemorrhage, and death.	Phenylpropanolamine	intracerebral hemorrhage	3987172	-1
-Phenylpropanolamine (PPA) overdose can cause severe hypertension, intracerebral hemorrhage, and death.	PPA	hypertension	3987172	1
-Phenylpropanolamine (PPA) overdose can cause severe hypertension, intracerebral hemorrhage, and death.	PPA	overdose	3987172	-1
-Phenylpropanolamine (PPA) overdose can cause severe hypertension, intracerebral hemorrhage, and death.	PPA	death	3987172	-1
-Phenylpropanolamine (PPA) overdose can cause severe hypertension, intracerebral hemorrhage, and death.	PPA	intracerebral hemorrhage	3987172	-1
-Indomethacin induced hypotension in sodium and volume depleted rats.	Indomethacin	hypotension	439781	1
-Indomethacin induced hypotension in sodium and volume depleted rats.	sodium	hypotension	439781	-1
-Proteinuria is an expected complication in transplant patients treated with mammalian target of rapamycin inhibitors (mTOR-i).	rapamycin inhibitors	Proteinuria	24040781	-1
-Crocin reduced inhibition of ERK activation and diazinon-induced hyperlipemia and increased levels of LDLr transcript.	Crocin	hyperlipemia	24132704	-1
-At detection of reduction in sural nerve SAP amplitude, the median thalidomide cumulative dose was 21.4 g. The threshold neurotoxic dosage is lower than previously reported.	thalidomide	neurotoxic	18450790	-1
-These results highlight the kinin B2 receptor antagonist treatment in amelioration of nephrotoxicity induced by cisplatin therapy.	cisplatin	nephrotoxicity	24975837	-1
-In this case we report the unexpected diagnosis of amyloidosis in a renal-transplant patient with pre-transplant monoclonal gammapathy of undetermined significance who developed proteinuria after conversion from tacrolimus to everolimus.	tacrolimus	monoclonal gammapathy	24040781	-1
-In this case we report the unexpected diagnosis of amyloidosis in a renal-transplant patient with pre-transplant monoclonal gammapathy of undetermined significance who developed proteinuria after conversion from tacrolimus to everolimus.	tacrolimus	amyloidosis	24040781	-1
-In this case we report the unexpected diagnosis of amyloidosis in a renal-transplant patient with pre-transplant monoclonal gammapathy of undetermined significance who developed proteinuria after conversion from tacrolimus to everolimus.	tacrolimus	proteinuria	24040781	-1
-In this case we report the unexpected diagnosis of amyloidosis in a renal-transplant patient with pre-transplant monoclonal gammapathy of undetermined significance who developed proteinuria after conversion from tacrolimus to everolimus.	everolimus	monoclonal gammapathy	24040781	-1
-In this case we report the unexpected diagnosis of amyloidosis in a renal-transplant patient with pre-transplant monoclonal gammapathy of undetermined significance who developed proteinuria after conversion from tacrolimus to everolimus.	everolimus	proteinuria	24040781	1
-A 27-year-old male patient presented with a maculopapular eruption on the flexural areas and buttocks after using oral ketoconazole.	ketoconazole	maculopapular eruption	24641119	1
-A case of a patient with hepatocellular carcinoma that developed neutropenia after treatment with quetiapine is described here.	quetiapine	hepatocellular carcinoma	25084821	-1
-Given that apomorphine inhibits passive avoidance retention when given during training or in a defined 10-12h post-training period, we evaluated the ability of nefiracetam to attenuate amnesia induced by dopaminergic agonism.	nefiracetam	amnesia	8829135	-1
-Given that apomorphine inhibits passive avoidance retention when given during training or in a defined 10-12h post-training period, we evaluated the ability of nefiracetam to attenuate amnesia induced by dopaminergic agonism.	apomorphine	amnesia	8829135	1
-Patients who did not receive mannitol were more likely to develop nephrotoxicity: odds ratio [OR] = 2.646 (95% CI = 1.008, 6.944; P = 0.048).	mannitol	nephrotoxicity	24778426	-1
-This is inconsistent with the well-established finding that nifedipine induces tachycardia in normally innervated hearts.	nifedipine	tachycardia	2614930	1
-An 84-year-old male received oral pilsicainide, a pure sodium channel blocker with slow recovery kinetics, to convert his paroxysmal atrial fibrillation to a sinus rhythm; the patient developed sudden cardiac death two days later.	pilsicainide	atrial fibrillation	24653743	-1
-An 84-year-old male received oral pilsicainide, a pure sodium channel blocker with slow recovery kinetics, to convert his paroxysmal atrial fibrillation to a sinus rhythm; the patient developed sudden cardiac death two days later.	pilsicainide	sudden cardiac death	24653743	1
-An 84-year-old male received oral pilsicainide, a pure sodium channel blocker with slow recovery kinetics, to convert his paroxysmal atrial fibrillation to a sinus rhythm; the patient developed sudden cardiac death two days later.	sodium	atrial fibrillation	24653743	-1
-An 84-year-old male received oral pilsicainide, a pure sodium channel blocker with slow recovery kinetics, to convert his paroxysmal atrial fibrillation to a sinus rhythm; the patient developed sudden cardiac death two days later.	sodium	sudden cardiac death	24653743	-1
-The myocardial content of catecholamines was estimated in these 8 day diabetic rats.	catecholamines	diabetic	3155884	-1
-Penicillamine-related lichenoid dermatitis and utility of zinc acetate in a Wilson disease patient with hepatic presentation, anxiety and SPECT abnormalities.	Penicillamine	anxiety	17346443	-1
-Penicillamine-related lichenoid dermatitis and utility of zinc acetate in a Wilson disease patient with hepatic presentation, anxiety and SPECT abnormalities.	Penicillamine	Wilson disease	17346443	-1
-Penicillamine-related lichenoid dermatitis and utility of zinc acetate in a Wilson disease patient with hepatic presentation, anxiety and SPECT abnormalities.	Penicillamine	lichenoid dermatitis	17346443	1
-Penicillamine-related lichenoid dermatitis and utility of zinc acetate in a Wilson disease patient with hepatic presentation, anxiety and SPECT abnormalities.	zinc acetate	anxiety	17346443	-1
-Penicillamine-related lichenoid dermatitis and utility of zinc acetate in a Wilson disease patient with hepatic presentation, anxiety and SPECT abnormalities.	zinc acetate	Wilson disease	17346443	-1
-Penicillamine-related lichenoid dermatitis and utility of zinc acetate in a Wilson disease patient with hepatic presentation, anxiety and SPECT abnormalities.	zinc acetate	lichenoid dermatitis	17346443	-1
-Mitochondrial impairment contributes to cocaine-induced cardiac dysfunction: Prevention by the targeted antioxidant MitoQ. The goal of this study was to assess mitochondrial function and ROS production in an experimental model of cocaine-induced cardiac dysfunction.	cocaine	cardiac dysfunction	20566328	1
-Mitochondrial impairment contributes to cocaine-induced cardiac dysfunction: Prevention by the targeted antioxidant MitoQ. The goal of this study was to assess mitochondrial function and ROS production in an experimental model of cocaine-induced cardiac dysfunction.	cocaine	cardiac dysfunction	20566328	1
-Mitochondrial impairment contributes to cocaine-induced cardiac dysfunction: Prevention by the targeted antioxidant MitoQ. The goal of this study was to assess mitochondrial function and ROS production in an experimental model of cocaine-induced cardiac dysfunction.	cocaine	Mitochondrial impairment	20566328	-1
-Mitochondrial impairment contributes to cocaine-induced cardiac dysfunction: Prevention by the targeted antioxidant MitoQ. The goal of this study was to assess mitochondrial function and ROS production in an experimental model of cocaine-induced cardiac dysfunction.	cocaine	cardiac dysfunction	20566328	1
-Mitochondrial impairment contributes to cocaine-induced cardiac dysfunction: Prevention by the targeted antioxidant MitoQ. The goal of this study was to assess mitochondrial function and ROS production in an experimental model of cocaine-induced cardiac dysfunction.	cocaine	Mitochondrial impairment	20566328	-1
-RESULTS: Among 167 methadone maintenance patients, the prevalence of QTc prolongation to 0.50 second((1/2)) or longer was 16.2% compared with 0% in 80 control subjects.	methadone	QTc prolongation	16801510	1
-Sprague-Dawley rats that were 20 days pregnant and nonpregnant rats of the same age and strain received infusions of aminophylline until onset of maximal seizures which occurred after 28 and 30 minutes respectively.	aminophylline	seizures	3339945	1
-Pulmonary hypertension after ibuprofen prophylaxis in very preterm infants.	ibuprofen	Pulmonary hypertension	11988250	1
-During the follow-up of our patient, penicillamine was interrupted after the appearance of a lichenoid dermatitis, and zinc acetate permitted to continue the successful treatment of the patient without side-effects.	penicillamine	lichenoid dermatitis	17346443	1
-During the follow-up of our patient, penicillamine was interrupted after the appearance of a lichenoid dermatitis, and zinc acetate permitted to continue the successful treatment of the patient without side-effects.	zinc acetate	lichenoid dermatitis	17346443	-1
-The authors conclude that in a patient starting DPH treatment an unexpected increase in seizures, with EEG and mental changes occurring simultaneously, should alert the physician to the possible need for eliminating DPH from the therapeutic regimen, even if plasma concentrations are low.	DPH	seizures	891494	-1
-The authors conclude that in a patient starting DPH treatment an unexpected increase in seizures, with EEG and mental changes occurring simultaneously, should alert the physician to the possible need for eliminating DPH from the therapeutic regimen, even if plasma concentrations are low.	DPH	seizures	891494	-1
-Nephropathy caused by Chinese herbs has previously been reported, usually involving the use of aristolochic acids.	aristolochic acids	Nephropathy	17028363	-1
-Azathioprine-induced suicidal erythrocyte death.	Azathioprine	death	18340638	-1
-However, the role of vasopressin remains to be determined in human essential hypertension.	vasopressin	hypertension	6321816	-1
-Neuroleptic drugs such as haloperidol, which block dopamine receptors, also cause catalepsy in rodents.	dopamine	catalepsy	10672628	-1
-Neuroleptic drugs such as haloperidol, which block dopamine receptors, also cause catalepsy in rodents.	haloperidol	catalepsy	10672628	1
-We conclude that coronary artery or myocardial disease is common (38%) in young asymptomatic chronic cocaine users.	cocaine	myocardial disease	11385188	1
-We conclude that coronary artery or myocardial disease is common (38%) in young asymptomatic chronic cocaine users.	cocaine	coronary artery	11385188	1
-In the present study, the effects of three alkylxanthines with different potencies as adenosine antagonists 8-phenyltheophylline, theophylline and enprofylline, were examined in rats developing acute renal failure after 4 daily injections of gentamicin (200 mg kg-1).	gentamicin	acute renal failure	2907577	1
-In the present study, the effects of three alkylxanthines with different potencies as adenosine antagonists 8-phenyltheophylline, theophylline and enprofylline, were examined in rats developing acute renal failure after 4 daily injections of gentamicin (200 mg kg-1).	8-phenyltheophylline	acute renal failure	2907577	-1
-In the present study, the effects of three alkylxanthines with different potencies as adenosine antagonists 8-phenyltheophylline, theophylline and enprofylline, were examined in rats developing acute renal failure after 4 daily injections of gentamicin (200 mg kg-1).	enprofylline	acute renal failure	2907577	-1
-In the present study, the effects of three alkylxanthines with different potencies as adenosine antagonists 8-phenyltheophylline, theophylline and enprofylline, were examined in rats developing acute renal failure after 4 daily injections of gentamicin (200 mg kg-1).	adenosine	acute renal failure	2907577	-1
-In the present study, the effects of three alkylxanthines with different potencies as adenosine antagonists 8-phenyltheophylline, theophylline and enprofylline, were examined in rats developing acute renal failure after 4 daily injections of gentamicin (200 mg kg-1).	theophylline	acute renal failure	2907577	-1
-Our results have shown that all adenosine receptor agonists (A1 and A2) reduce cocaine- and amphetamine-induced locomotor activity and indicate that cocaine-induced hyperactivity is more influenced by adenosine receptor agonists (particularly A1 receptors) than amphetamine-induced hyperactivity.	cocaine-	hyperactivity	12523489	-1
-Our results have shown that all adenosine receptor agonists (A1 and A2) reduce cocaine- and amphetamine-induced locomotor activity and indicate that cocaine-induced hyperactivity is more influenced by adenosine receptor agonists (particularly A1 receptors) than amphetamine-induced hyperactivity.	cocaine-	hyperactivity	12523489	-1
-Our results have shown that all adenosine receptor agonists (A1 and A2) reduce cocaine- and amphetamine-induced locomotor activity and indicate that cocaine-induced hyperactivity is more influenced by adenosine receptor agonists (particularly A1 receptors) than amphetamine-induced hyperactivity.	cocaine	hyperactivity	12523489	-1
-Our results have shown that all adenosine receptor agonists (A1 and A2) reduce cocaine- and amphetamine-induced locomotor activity and indicate that cocaine-induced hyperactivity is more influenced by adenosine receptor agonists (particularly A1 receptors) than amphetamine-induced hyperactivity.	cocaine	hyperactivity	12523489	-1
-Our results have shown that all adenosine receptor agonists (A1 and A2) reduce cocaine- and amphetamine-induced locomotor activity and indicate that cocaine-induced hyperactivity is more influenced by adenosine receptor agonists (particularly A1 receptors) than amphetamine-induced hyperactivity.	adenosine	hyperactivity	12523489	-1
-Our results have shown that all adenosine receptor agonists (A1 and A2) reduce cocaine- and amphetamine-induced locomotor activity and indicate that cocaine-induced hyperactivity is more influenced by adenosine receptor agonists (particularly A1 receptors) than amphetamine-induced hyperactivity.	adenosine	hyperactivity	12523489	-1
-Our results have shown that all adenosine receptor agonists (A1 and A2) reduce cocaine- and amphetamine-induced locomotor activity and indicate that cocaine-induced hyperactivity is more influenced by adenosine receptor agonists (particularly A1 receptors) than amphetamine-induced hyperactivity.	adenosine	hyperactivity	12523489	-1
-Our results have shown that all adenosine receptor agonists (A1 and A2) reduce cocaine- and amphetamine-induced locomotor activity and indicate that cocaine-induced hyperactivity is more influenced by adenosine receptor agonists (particularly A1 receptors) than amphetamine-induced hyperactivity.	adenosine	hyperactivity	12523489	-1
-Our results have shown that all adenosine receptor agonists (A1 and A2) reduce cocaine- and amphetamine-induced locomotor activity and indicate that cocaine-induced hyperactivity is more influenced by adenosine receptor agonists (particularly A1 receptors) than amphetamine-induced hyperactivity.	amphetamine	hyperactivity	12523489	-1
-Our results have shown that all adenosine receptor agonists (A1 and A2) reduce cocaine- and amphetamine-induced locomotor activity and indicate that cocaine-induced hyperactivity is more influenced by adenosine receptor agonists (particularly A1 receptors) than amphetamine-induced hyperactivity.	amphetamine	hyperactivity	12523489	-1
-Our results have shown that all adenosine receptor agonists (A1 and A2) reduce cocaine- and amphetamine-induced locomotor activity and indicate that cocaine-induced hyperactivity is more influenced by adenosine receptor agonists (particularly A1 receptors) than amphetamine-induced hyperactivity.	amphetamine	hyperactivity	12523489	-1
-Our results have shown that all adenosine receptor agonists (A1 and A2) reduce cocaine- and amphetamine-induced locomotor activity and indicate that cocaine-induced hyperactivity is more influenced by adenosine receptor agonists (particularly A1 receptors) than amphetamine-induced hyperactivity.	amphetamine	hyperactivity	12523489	-1
-Alternatively, anemia could result from accelerated suicidal erythrocyte death or eryptosis, which is characterized by exposure of phosphatidylserine (PS) at the erythrocyte surface and by cell shrinkage.	phosphatidylserine	anemia	18340638	-1
-Alternatively, anemia could result from accelerated suicidal erythrocyte death or eryptosis, which is characterized by exposure of phosphatidylserine (PS) at the erythrocyte surface and by cell shrinkage.	phosphatidylserine	death	18340638	-1
-Alternatively, anemia could result from accelerated suicidal erythrocyte death or eryptosis, which is characterized by exposure of phosphatidylserine (PS) at the erythrocyte surface and by cell shrinkage.	PS	anemia	18340638	-1
-Alternatively, anemia could result from accelerated suicidal erythrocyte death or eryptosis, which is characterized by exposure of phosphatidylserine (PS) at the erythrocyte surface and by cell shrinkage.	PS	death	18340638	-1
-Similarly, significant disturbances in myocardial energy metabolism were detected in the barium-exposed rats which were consistent with the reduced contractile element shortening velocity.	barium	disturbances in myocardial energy metabolism	3975902	-1
-The trimethaphan-induced hypotension was accompanied by a significant bradycardia in lesioned rats (-32 +/-	trimethaphan	hypotension	1735570	1
-The trimethaphan-induced hypotension was accompanied by a significant bradycardia in lesioned rats (-32 +/-	trimethaphan	bradycardia	1735570	-1
-DESIGN: Dose response curves for nonsedating doses of morphine and CNSB002 given intraperitoneally alone and together in combinations were constructed for antihyperalgesic effect using paw withdrawal from noxious heat in two rat pain models: carrageenan-induced paw inflammation and streptozotocin (STZ)-induced diabetic neuropathy.	CNSB002	pain	20447294	-1
-DESIGN: Dose response curves for nonsedating doses of morphine and CNSB002 given intraperitoneally alone and together in combinations were constructed for antihyperalgesic effect using paw withdrawal from noxious heat in two rat pain models: carrageenan-induced paw inflammation and streptozotocin (STZ)-induced diabetic neuropathy.	CNSB002	diabetic neuropathy	20447294	-1
-DESIGN: Dose response curves for nonsedating doses of morphine and CNSB002 given intraperitoneally alone and together in combinations were constructed for antihyperalgesic effect using paw withdrawal from noxious heat in two rat pain models: carrageenan-induced paw inflammation and streptozotocin (STZ)-induced diabetic neuropathy.	CNSB002	inflammation	20447294	-1
-DESIGN: Dose response curves for nonsedating doses of morphine and CNSB002 given intraperitoneally alone and together in combinations were constructed for antihyperalgesic effect using paw withdrawal from noxious heat in two rat pain models: carrageenan-induced paw inflammation and streptozotocin (STZ)-induced diabetic neuropathy.	morphine	pain	20447294	-1
-DESIGN: Dose response curves for nonsedating doses of morphine and CNSB002 given intraperitoneally alone and together in combinations were constructed for antihyperalgesic effect using paw withdrawal from noxious heat in two rat pain models: carrageenan-induced paw inflammation and streptozotocin (STZ)-induced diabetic neuropathy.	morphine	diabetic neuropathy	20447294	-1
-DESIGN: Dose response curves for nonsedating doses of morphine and CNSB002 given intraperitoneally alone and together in combinations were constructed for antihyperalgesic effect using paw withdrawal from noxious heat in two rat pain models: carrageenan-induced paw inflammation and streptozotocin (STZ)-induced diabetic neuropathy.	morphine	inflammation	20447294	-1
-DESIGN: Dose response curves for nonsedating doses of morphine and CNSB002 given intraperitoneally alone and together in combinations were constructed for antihyperalgesic effect using paw withdrawal from noxious heat in two rat pain models: carrageenan-induced paw inflammation and streptozotocin (STZ)-induced diabetic neuropathy.	carrageenan	pain	20447294	-1
-DESIGN: Dose response curves for nonsedating doses of morphine and CNSB002 given intraperitoneally alone and together in combinations were constructed for antihyperalgesic effect using paw withdrawal from noxious heat in two rat pain models: carrageenan-induced paw inflammation and streptozotocin (STZ)-induced diabetic neuropathy.	carrageenan	diabetic neuropathy	20447294	-1
-DESIGN: Dose response curves for nonsedating doses of morphine and CNSB002 given intraperitoneally alone and together in combinations were constructed for antihyperalgesic effect using paw withdrawal from noxious heat in two rat pain models: carrageenan-induced paw inflammation and streptozotocin (STZ)-induced diabetic neuropathy.	streptozotocin	pain	20447294	-1
-DESIGN: Dose response curves for nonsedating doses of morphine and CNSB002 given intraperitoneally alone and together in combinations were constructed for antihyperalgesic effect using paw withdrawal from noxious heat in two rat pain models: carrageenan-induced paw inflammation and streptozotocin (STZ)-induced diabetic neuropathy.	streptozotocin	diabetic neuropathy	20447294	1
-DESIGN: Dose response curves for nonsedating doses of morphine and CNSB002 given intraperitoneally alone and together in combinations were constructed for antihyperalgesic effect using paw withdrawal from noxious heat in two rat pain models: carrageenan-induced paw inflammation and streptozotocin (STZ)-induced diabetic neuropathy.	streptozotocin	inflammation	20447294	-1
-DESIGN: Dose response curves for nonsedating doses of morphine and CNSB002 given intraperitoneally alone and together in combinations were constructed for antihyperalgesic effect using paw withdrawal from noxious heat in two rat pain models: carrageenan-induced paw inflammation and streptozotocin (STZ)-induced diabetic neuropathy.	STZ)-induced	pain	20447294	-1
-DESIGN: Dose response curves for nonsedating doses of morphine and CNSB002 given intraperitoneally alone and together in combinations were constructed for antihyperalgesic effect using paw withdrawal from noxious heat in two rat pain models: carrageenan-induced paw inflammation and streptozotocin (STZ)-induced diabetic neuropathy.	STZ)-induced	inflammation	20447294	-1
-The natural history of Vigabatrin associated visual field defects in patients electing to continue their medication.	Vigabatrin	visual field defects	15094729	-1
-A case of bilateral optic neuropathy in a patient on tacrolimus (FK506) therapy after liver transplantation.	tacrolimus	optic neuropathy	10764869	1
-A case of bilateral optic neuropathy in a patient on tacrolimus (FK506) therapy after liver transplantation.	FK506	optic neuropathy	10764869	1
-PURPOSE: To report a case of bilateral optic neuropathy in a patient receiving tacrolimus (FK 506, Prograf; Fujisawa USA, Inc, Deerfield, Illinois) for immunosuppression after orthotropic liver transplantation.	tacrolimus	optic neuropathy	10764869	1
-PURPOSE: To report a case of bilateral optic neuropathy in a patient receiving tacrolimus (FK 506, Prograf; Fujisawa USA, Inc, Deerfield, Illinois) for immunosuppression after orthotropic liver transplantation.	FK 506	optic neuropathy	10764869	1
-CONCLUSIONS: Azathioprine triggers suicidal erythrocyte death, an effect presumably contributing to azathioprine-induced anemia.	Azathioprine	anemia	18340638	1
-CONCLUSIONS: Azathioprine triggers suicidal erythrocyte death, an effect presumably contributing to azathioprine-induced anemia.	Azathioprine	death	18340638	-1
-CONCLUSIONS: Azathioprine triggers suicidal erythrocyte death, an effect presumably contributing to azathioprine-induced anemia.	azathioprine	death	18340638	-1
-Nasal hypoplasia with or without stippled epiphyses has now been reported in 11 infants born to mothers treated with warfarin during the first trimester, and a causal association is probable.	warfarin	Nasal hypoplasia	920167	-1
-Amiodarone and the risk of bradyarrhythmia requiring permanent pacemaker in elderly patients with atrial fibrillation and prior myocardial infarction.	Amiodarone	myocardial infarction	12535818	-1
-Amiodarone and the risk of bradyarrhythmia requiring permanent pacemaker in elderly patients with atrial fibrillation and prior myocardial infarction.	Amiodarone	atrial fibrillation	12535818	-1
-She had developed a severe acute major depression disorder almost immediately thereafter, possibly related to the use of a serotonin antagonist.	serotonin	major depression disorder	9323412	-1
-OBJECTIVES: The aim of this study was to determine whether the use of amiodarone in patients with atrial fibrillation (AF) increases the risk of bradyarrhythmia requiring a permanent pacemaker.	amiodarone	atrial fibrillation	12535818	-1
-OBJECTIVES: The aim of this study was to determine whether the use of amiodarone in patients with atrial fibrillation (AF) increases the risk of bradyarrhythmia requiring a permanent pacemaker.	amiodarone	AF	12535818	-1
-We conclude that patients may be restarted on inhaled beclomethasone when clinically indicated; however, because of the high recurrence rate, patients who develop hoarseness should not be re-challenged.	beclomethasone	hoarseness	3475563	1
-CONCLUSION: Tacrolimus and other immunosuppressive agents may be associated with optic nerve toxicity.	Tacrolimus	optic nerve toxicity	10764869	-1
-Our findings indicate that sustained-release nifedipine is useful for hypertensive psoriatic patients under long-term treatment with cyclosporin A, but that these patients should be monitored for gingival hyperplasia.	nifedipine	hypertensive psoriatic	9889429	-1
-Our findings indicate that sustained-release nifedipine is useful for hypertensive psoriatic patients under long-term treatment with cyclosporin A, but that these patients should be monitored for gingival hyperplasia.	cyclosporin A	hypertensive psoriatic	9889429	1
-BACKGROUND: Reports of severe bradyarrhythmia during amiodarone therapy are infrequent and limited to studies assessing the therapy's use in the management of patients with ventricular arrhythmias.	amiodarone	ventricular arrhythmias	12535818	-1
-BACKGROUND: Reports of severe bradyarrhythmia during amiodarone therapy are infrequent and limited to studies assessing the therapy's use in the management of patients with ventricular arrhythmias.	amiodarone	bradyarrhythmia	12535818	1
-We report a 23-year-old woman who developed acute renal failure following prolonged use of a proprietary Chinese herbal slimming pill that contained anthraquinone derivatives, extracted from Rhizoma Rhei (rhubarb).	anthraquinone	acute renal failure	17028363	-1
-The renal injury was probably aggravated by the concomitant intake of a non-steroidal anti-inflammatory drug, diclofenac.	diclofenac	renal injury	17028363	-1
-Thalidomide and sensory neurotoxicity: a neurophysiological study.	Thalidomide	neurotoxicity	18450790	-1
-The doses calculated to cause 50% reversal of hyperalgesia (ED50) were 7.54 (1.81) and 4.83 (1.54) in the carrageenan model and 44.18 (1.37) and 9.14 (1.24) in the STZ-induced neuropathy model for CNSB002 and morphine, respectively (mg/kg; mean, SEM).	CNSB002	neuropathy	20447294	-1
-The doses calculated to cause 50% reversal of hyperalgesia (ED50) were 7.54 (1.81) and 4.83 (1.54) in the carrageenan model and 44.18 (1.37) and 9.14 (1.24) in the STZ-induced neuropathy model for CNSB002 and morphine, respectively (mg/kg; mean, SEM).	CNSB002	hyperalgesia	20447294	-1
-The doses calculated to cause 50% reversal of hyperalgesia (ED50) were 7.54 (1.81) and 4.83 (1.54) in the carrageenan model and 44.18 (1.37) and 9.14 (1.24) in the STZ-induced neuropathy model for CNSB002 and morphine, respectively (mg/kg; mean, SEM).	STZ	neuropathy	20447294	-1
-The doses calculated to cause 50% reversal of hyperalgesia (ED50) were 7.54 (1.81) and 4.83 (1.54) in the carrageenan model and 44.18 (1.37) and 9.14 (1.24) in the STZ-induced neuropathy model for CNSB002 and morphine, respectively (mg/kg; mean, SEM).	carrageenan	neuropathy	20447294	-1
-The doses calculated to cause 50% reversal of hyperalgesia (ED50) were 7.54 (1.81) and 4.83 (1.54) in the carrageenan model and 44.18 (1.37) and 9.14 (1.24) in the STZ-induced neuropathy model for CNSB002 and morphine, respectively (mg/kg; mean, SEM).	carrageenan	hyperalgesia	20447294	1
-The doses calculated to cause 50% reversal of hyperalgesia (ED50) were 7.54 (1.81) and 4.83 (1.54) in the carrageenan model and 44.18 (1.37) and 9.14 (1.24) in the STZ-induced neuropathy model for CNSB002 and morphine, respectively (mg/kg; mean, SEM).	morphine	neuropathy	20447294	-1
-The doses calculated to cause 50% reversal of hyperalgesia (ED50) were 7.54 (1.81) and 4.83 (1.54) in the carrageenan model and 44.18 (1.37) and 9.14 (1.24) in the STZ-induced neuropathy model for CNSB002 and morphine, respectively (mg/kg; mean, SEM).	morphine	hyperalgesia	20447294	-1
-Association of common genetic variants of HOMER1 gene with levodopa adverse effects in Parkinson's disease patients.	levodopa	Parkinson's disease	24126708	-1
-Significantly more weight gain occurred with olanzapine than with risperidone: the increase in weight at 4 months relative to baseline weight was 17.3% (95% CI=14.2%-20.5%) with olanzapine and 11.3% (95% CI=8.4%-14.3%) with risperidone.	risperidone	weight gain	17151160	1
-Significantly more weight gain occurred with olanzapine than with risperidone: the increase in weight at 4 months relative to baseline weight was 17.3% (95% CI=14.2%-20.5%) with olanzapine and 11.3% (95% CI=8.4%-14.3%) with risperidone.	olanzapine	weight gain	17151160	1
-Although a causal relationship between the use of an anthraquinone-containing herbal agent and renal injury remains to be proven, phytotherapy-associated interstitial nephropathy should be considered in patients who present with unexplained renal failure.	anthraquinone	renal injury	17028363	-1
-Although a causal relationship between the use of an anthraquinone-containing herbal agent and renal injury remains to be proven, phytotherapy-associated interstitial nephropathy should be considered in patients who present with unexplained renal failure.	anthraquinone	interstitial nephropathy	17028363	-1
-Although a causal relationship between the use of an anthraquinone-containing herbal agent and renal injury remains to be proven, phytotherapy-associated interstitial nephropathy should be considered in patients who present with unexplained renal failure.	anthraquinone	renal failure	17028363	-1
-CONCLUSIONS: When limited quantities of mannitol are available, it should preferentially be given to patients at particularly high risk of nephrotoxicity.	mannitol	nephrotoxicity	24778426	-1
-PATIENTS AND METHODS: Clinical and electrophysiological data in 12 female patients with CLE during treatment with thalidomide and up to 47 months after discontinuation of treatment were analysed.	thalidomide	CLE	18450790	-1
-This complication appears to represent a significant new toxicity of high-dose etoposide therapy for malignant glioma.	etoposide	malignant glioma	3289726	-1
-This complication appears to represent a significant new toxicity of high-dose etoposide therapy for malignant glioma.	etoposide	toxicity	3289726	-1
-CONCLUSIONS: QT interval prolongation in methadone maintenance patients hospitalized in a tertiary care center is a frequent finding.	methadone	QT interval prolongation	16801510	1
-CONCLUSIONS: The data suggest that neuropsychiatric disorders in PD are more likely an interaction between levodopa and the disease state than a consequence of sensitisation to repeated dopaminergic therapy.	levodopa	neuropsychiatric disorders	20169779	-1
-CONCLUSIONS: The data suggest that neuropsychiatric disorders in PD are more likely an interaction between levodopa and the disease state than a consequence of sensitisation to repeated dopaminergic therapy.	levodopa	PD	20169779	-1
-This study shows that 17alpha-ethinylestradiol (EE)-induced intrahepatic cholestasis in rats is associated with selective inhibition of the neutral pathway of bile salt (BS) synthesis.	17alpha-ethinylestradiol	intrahepatic cholestasis	9869655	1
-This study shows that 17alpha-ethinylestradiol (EE)-induced intrahepatic cholestasis in rats is associated with selective inhibition of the neutral pathway of bile salt (BS) synthesis.	EE)-induced	intrahepatic cholestasis	9869655	1
-CONCLUSIONS: This study suggests that the use of amiodarone in elderly patients with AF and a previous MI increases the risk of bradyarrhythmia requiring a permanent pacemaker.	amiodarone	MI	12535818	-1
-CONCLUSIONS: This study suggests that the use of amiodarone in elderly patients with AF and a previous MI increases the risk of bradyarrhythmia requiring a permanent pacemaker.	amiodarone	AF	12535818	-1
-Clinical trials of aminoglycosides in seriously ill patients indicate that the relative risk for developing acute renal failure during therapy ranges from 8 to 10 and that the attributable risk is 70% to 80%.	aminoglycosides	acute renal failure	3538855	-1
-We describe a case of clopidogrel-related acute hepatitis.	clopidogrel	hepatitis	23846525	1
-Naloxone (0.3, 1, 3, and 10 mg/kg) injected prior to training attenuated the retention deficit with a peak of activity at 3 mg/kg.	Naloxone	retention deficit	3088653	-1
-Signs of FZP toxocity in cats included excessive salivation, extreme apprehensive behavior, retching, muscle tremors and convulsions.	FZP	convulsions	6106951	1
-Signs of FZP toxocity in cats included excessive salivation, extreme apprehensive behavior, retching, muscle tremors and convulsions.	FZP	muscle tremors	6106951	-1
-BACKGROUND: Recent studies confirmed a high incidence of sensory axonal neuropathy in patients treated with different doses of thalidomide.	thalidomide	sensory axonal neuropathy	18450790	-1
-Reports about cases of hepatotoxicity due to clopidogrel are increasing in the last few years, after the increased use of this drug.	clopidogrel	hepatotoxicity	23846525	1
-Thus, two control groups were generated: group C1, which included age- and sex-comparable lithium-treated bipolar normocalcemic patients, and group C2, which included bipolar normocalcemic patients treated with anticonvulsant mood stabilizers.	lithium	bipolar normocalcemic	10770468	-1
-Thus, two control groups were generated: group C1, which included age- and sex-comparable lithium-treated bipolar normocalcemic patients, and group C2, which included bipolar normocalcemic patients treated with anticonvulsant mood stabilizers.	lithium	bipolar normocalcemic	10770468	-1
-Drug-induced long QT syndrome in injection drug users receiving methadone: high frequency in hospitalized patients and risk factors.	methadone	long QT syndrome	16801510	1
-RESULTS: The incidence and severity of visible muscle fasciculation was significantly less with increasing the amount of precurarizing dose of rocuronium (P < 0.001).	rocuronium	muscle fasciculation	25006369	-1
-In conclusion, we believe that physicians should carefully consider the risk of drug-induced hepatic injury when clopidogrel is prescribed.	clopidogrel	hepatic injury	23846525	1
-OBJECTIVE: A multicenter, controlled trial showed that early blockade of the renin-angiotensin system in patients with type 1 diabetes and normoalbuminuria did not retard the progression of nephropathy, suggesting that other mechanism(s) are involved in the pathogenesis of early diabetic nephropathy (diabetic nephropathy).	angiotensin	diabetic nephropathy	20682692	-1
-OBJECTIVE: A multicenter, controlled trial showed that early blockade of the renin-angiotensin system in patients with type 1 diabetes and normoalbuminuria did not retard the progression of nephropathy, suggesting that other mechanism(s) are involved in the pathogenesis of early diabetic nephropathy (diabetic nephropathy).	angiotensin	diabetic nephropathy	20682692	-1
-OBJECTIVE: A multicenter, controlled trial showed that early blockade of the renin-angiotensin system in patients with type 1 diabetes and normoalbuminuria did not retard the progression of nephropathy, suggesting that other mechanism(s) are involved in the pathogenesis of early diabetic nephropathy (diabetic nephropathy).	angiotensin	diabetes	20682692	-1
-OBJECTIVE: A multicenter, controlled trial showed that early blockade of the renin-angiotensin system in patients with type 1 diabetes and normoalbuminuria did not retard the progression of nephropathy, suggesting that other mechanism(s) are involved in the pathogenesis of early diabetic nephropathy (diabetic nephropathy).	angiotensin	nephropathy	20682692	-1
-Branch retinal vein occlusion and fluoxetine.	fluoxetine	Branch retinal vein occlusion	18025637	1
-Two courses of 21 days of 5 mg norethisterone daily caused reversion to normal in all 57 cases of cystic hyperplasia and 6 of the 8 cases of atypical hyperplasia.	norethisterone	cystic hyperplasia	89511	-1
-Two courses of 21 days of 5 mg norethisterone daily caused reversion to normal in all 57 cases of cystic hyperplasia and 6 of the 8 cases of atypical hyperplasia.	norethisterone	hyperplasia	89511	-1
-Independent predictors of postoperative seizures included age, female sex, redo cardiac surgery, calcification of ascending aorta, congestive heart failure, deep hypothermic circulatory arrest, duration of aortic cross-clamp and tranexamic acid.	tranexamic acid	congestive heart failure	24588023	-1
-Independent predictors of postoperative seizures included age, female sex, redo cardiac surgery, calcification of ascending aorta, congestive heart failure, deep hypothermic circulatory arrest, duration of aortic cross-clamp and tranexamic acid.	tranexamic acid	postoperative seizures	24588023	-1
-Independent predictors of postoperative seizures included age, female sex, redo cardiac surgery, calcification of ascending aorta, congestive heart failure, deep hypothermic circulatory arrest, duration of aortic cross-clamp and tranexamic acid.	tranexamic acid	calcification	24588023	-1
-Independent predictors of postoperative seizures included age, female sex, redo cardiac surgery, calcification of ascending aorta, congestive heart failure, deep hypothermic circulatory arrest, duration of aortic cross-clamp and tranexamic acid.	tranexamic acid	deep hypothermic circulatory arrest	24588023	-1
-Methadone dose, presence of cytochrome P-450 3A4 inhibitors, potassium level, and liver function contribute to QT prolongation.	Methadone	QT prolongation	16801510	1
-Methadone dose, presence of cytochrome P-450 3A4 inhibitors, potassium level, and liver function contribute to QT prolongation.	potassium	QT prolongation	16801510	-1
-Persistent sterile leukocyturia is associated with impaired renal function in human immunodeficiency virus type 1-infected children treated with indinavir.	indinavir	human immunodeficiency virus type 1-infected	12165618	-1
-Persistent sterile leukocyturia is associated with impaired renal function in human immunodeficiency virus type 1-infected children treated with indinavir.	indinavir	sterile leukocyturia	12165618	-1
-Patients with hypercalcemia resulting from medical diseases and bipolar patients with lithium-associated hypercalcemia had significantly higher frequencies of conduction defects.	lithium	bipolar	10770468	-1
-Patients with hypercalcemia resulting from medical diseases and bipolar patients with lithium-associated hypercalcemia had significantly higher frequencies of conduction defects.	lithium	hypercalcemia	10770468	1
-Patients with hypercalcemia resulting from medical diseases and bipolar patients with lithium-associated hypercalcemia had significantly higher frequencies of conduction defects.	lithium	hypercalcemia	10770468	1
-Patients with hypercalcemia resulting from medical diseases and bipolar patients with lithium-associated hypercalcemia had significantly higher frequencies of conduction defects.	lithium	diseases	10770468	-1
-CONCLUSIONS AND CLINICAL RELEVANCE: Results suggested that levetiracetam is well tolerated in cats and may be useful as an adjunct to phenobarbital treatment in cats with idiopathic epilepsy.	levetiracetam	idiopathic epilepsy	18341442	-1
-CONCLUSIONS AND CLINICAL RELEVANCE: Results suggested that levetiracetam is well tolerated in cats and may be useful as an adjunct to phenobarbital treatment in cats with idiopathic epilepsy.	phenobarbital	idiopathic epilepsy	18341442	-1
-The study's aims were to measure variations in sural nerve sensory action potential (SAP) amplitude in patients with refractory cutaneous lupus erythematosus (CLE) treated with thalidomide and use these findings to identify the neurotoxic potential of thalidomide and the recovery capacity of sensory fibres after discontinuation of treatment.	thalidomide	neurotoxic	18450790	-1
-The study's aims were to measure variations in sural nerve sensory action potential (SAP) amplitude in patients with refractory cutaneous lupus erythematosus (CLE) treated with thalidomide and use these findings to identify the neurotoxic potential of thalidomide and the recovery capacity of sensory fibres after discontinuation of treatment.	thalidomide	cutaneous lupus erythematosus	18450790	-1
-The study's aims were to measure variations in sural nerve sensory action potential (SAP) amplitude in patients with refractory cutaneous lupus erythematosus (CLE) treated with thalidomide and use these findings to identify the neurotoxic potential of thalidomide and the recovery capacity of sensory fibres after discontinuation of treatment.	thalidomide	CLE	18450790	-1
-The study's aims were to measure variations in sural nerve sensory action potential (SAP) amplitude in patients with refractory cutaneous lupus erythematosus (CLE) treated with thalidomide and use these findings to identify the neurotoxic potential of thalidomide and the recovery capacity of sensory fibres after discontinuation of treatment.	thalidomide	neurotoxic	18450790	-1
-The study's aims were to measure variations in sural nerve sensory action potential (SAP) amplitude in patients with refractory cutaneous lupus erythematosus (CLE) treated with thalidomide and use these findings to identify the neurotoxic potential of thalidomide and the recovery capacity of sensory fibres after discontinuation of treatment.	thalidomide	cutaneous lupus erythematosus	18450790	-1
-The study's aims were to measure variations in sural nerve sensory action potential (SAP) amplitude in patients with refractory cutaneous lupus erythematosus (CLE) treated with thalidomide and use these findings to identify the neurotoxic potential of thalidomide and the recovery capacity of sensory fibres after discontinuation of treatment.	thalidomide	CLE	18450790	-1
-Milk-alkali syndrome was first described 70 years ago in the context of the treatment of peptic ulcer disease with large amounts of calcium and alkali.	calcium	peptic ulcer disease	8667442	-1
-Milk-alkali syndrome was first described 70 years ago in the context of the treatment of peptic ulcer disease with large amounts of calcium and alkali.	calcium	Milk-alkali syndrome	8667442	1
-The aim of this work is to call attention to the risk of tacrolimus use in patients with SSc.	tacrolimus	SSc	22836123	1
-We suggest that ecstasy-associated dysfunction in fronto-temporal circuitry may underlie overnight consolidation memory impairments in regular ecstasy users.	ecstasy	memory impairments	24595967	1
-OBJECTIVE: To assess pharmacokinetics, efficacy, and tolerability of oral levetiracetam administered as an adjunct to phenobarbital treatment in cats with poorly controlled suspected idiopathic epilepsy.	levetiracetam	idiopathic epilepsy	18341442	-1
-OBJECTIVE: To assess pharmacokinetics, efficacy, and tolerability of oral levetiracetam administered as an adjunct to phenobarbital treatment in cats with poorly controlled suspected idiopathic epilepsy.	phenobarbital	idiopathic epilepsy	18341442	-1
-Long QT syndrome can occur with low doses of methadone.	methadone	Long QT syndrome	16801510	1
-Procaterol and terbutaline in bronchial asthma.	terbutaline	bronchial asthma	2933998	-1
-Procaterol and terbutaline in bronchial asthma.	Procaterol	bronchial asthma	2933998	-1
-In conclusion, clentiazem attenuated epinephrine-induced cardiac injury, possibly through its effect on the adrenergic pathway.	epinephrine	cardiac injury	8392553	-1
-In conclusion, clentiazem attenuated epinephrine-induced cardiac injury, possibly through its effect on the adrenergic pathway.	clentiazem	cardiac injury	8392553	-1
-LF prevented body weight loss and significantly reduced the elevated plasma H2O2 and increased FRAP values.	H2O2	weight loss	24587916	-1
-LF prevented body weight loss and significantly reduced the elevated plasma H2O2 and increased FRAP values.	LF	weight loss	24587916	-1
-The antinociception after morphine (3.2 mg/kg) was increased by co-administration with CNSB002 from 28.0 and 31.7% to 114.6 and 56.9% reversal of hyperalgesia in the inflammatory and neuropathic models, respectively (P < 0.01; one-way analysis of variance-significantly greater than either drug given alone).	CNSB002	hyperalgesia	20447294	-1
-The antinociception after morphine (3.2 mg/kg) was increased by co-administration with CNSB002 from 28.0 and 31.7% to 114.6 and 56.9% reversal of hyperalgesia in the inflammatory and neuropathic models, respectively (P < 0.01; one-way analysis of variance-significantly greater than either drug given alone).	morphine	hyperalgesia	20447294	-1
-An increase of creatine phosphokinase to >5 times the upper limit of normal occurred in 0.24% of patients, and no cases of drug-induced myopathy were observed. Niacin extended-release/lovastatin 1,000/40 mg, dosed as initial therapy, was associated with good compliance and safety and had very low incidences of increased liver and muscle enzymes.	lovastatin	myopathy	15276093	-1
-An increase of creatine phosphokinase to >5 times the upper limit of normal occurred in 0.24% of patients, and no cases of drug-induced myopathy were observed. Niacin extended-release/lovastatin 1,000/40 mg, dosed as initial therapy, was associated with good compliance and safety and had very low incidences of increased liver and muscle enzymes.	Niacin	myopathy	15276093	-1
-An increase of creatine phosphokinase to >5 times the upper limit of normal occurred in 0.24% of patients, and no cases of drug-induced myopathy were observed. Niacin extended-release/lovastatin 1,000/40 mg, dosed as initial therapy, was associated with good compliance and safety and had very low incidences of increased liver and muscle enzymes.	creatine	myopathy	15276093	-1
-After recovery from hyperglycaemia, he remained polyuric despite normal blood glucose concentrations; water deprivation testing indicated nephrogenic diabetes insipidus, likely to be lithium-induced.	glucose	nephrogenic diabetes insipidus	9538487	-1
-In a prevention study, rats received 4 days of LF treatment followed by Dex and continued during the test period.	Dex	LF	24587916	-1
-Dexamethasone induced the transcriptional factor CHOP, a marker for chronic ER stress, in the anterior segment tissues, and Chop deletion reduced ER stress in these tissues and prevented dexamethasone-induced ocular hypertension.	Dexamethasone	ocular hypertension	24691439	1
-Dexamethasone induced the transcriptional factor CHOP, a marker for chronic ER stress, in the anterior segment tissues, and Chop deletion reduced ER stress in these tissues and prevented dexamethasone-induced ocular hypertension.	dexamethasone	ocular hypertension	24691439	1
-Theophylline neurotoxicity in pregnant rats.	Theophylline	neurotoxicity	3339945	-1
-Increases of MAP occurred after LV administration of 1, 10 and 50 ng of AVP in WKY and of 10 and 50 ng in SHR.	AVP	LV	8188982	-1
-Cardiovascular dysfunction and hypersensitivity to sodium pentobarbital induced by chronic barium chloride ingestion.	sodium pentobarbital	Cardiovascular dysfunction	3975902	-1
-Cardiovascular dysfunction and hypersensitivity to sodium pentobarbital induced by chronic barium chloride ingestion.	sodium pentobarbital	hypersensitivity	3975902	-1
-Cardiovascular dysfunction and hypersensitivity to sodium pentobarbital induced by chronic barium chloride ingestion.	barium chloride	Cardiovascular dysfunction	3975902	-1
-Cardiovascular dysfunction and hypersensitivity to sodium pentobarbital induced by chronic barium chloride ingestion.	barium chloride	hypersensitivity	3975902	-1
-Takotsubo syndrome (or apical ballooning syndrome) secondary to Zolmitriptan.	Zolmitriptan	Takotsubo syndrome	24100257	1
-Takotsubo syndrome (or apical ballooning syndrome) secondary to Zolmitriptan.	Zolmitriptan	apical ballooning syndrome	24100257	1
-In summary, our results showed that betaine pretreatment attenuated isoproterenol-induced acute myocardial ischemia via the regulation of STAT3 and apoptotic pathways.	isoproterenol	myocardial ischemia	25080425	1
-In summary, our results showed that betaine pretreatment attenuated isoproterenol-induced acute myocardial ischemia via the regulation of STAT3 and apoptotic pathways.	betaine	myocardial ischemia	25080425	-1
-The main side-effects were headache, dizziness, palpitation and flushing and these were not more frequent than reported in other studies with isradipine or with placebo.	isradipine	headache	1451544	1
-The main side-effects were headache, dizziness, palpitation and flushing and these were not more frequent than reported in other studies with isradipine or with placebo.	isradipine	flushing	1451544	1
-The main side-effects were headache, dizziness, palpitation and flushing and these were not more frequent than reported in other studies with isradipine or with placebo.	isradipine	dizziness	1451544	1
-A case of intercerebral hematoma due to warfarin-induced coagulopathy is presented.	warfarin	coagulopathy	8308951	-1
-A case of intercerebral hematoma due to warfarin-induced coagulopathy is presented.	warfarin	intercerebral hematoma	8308951	-1
-Furthermore, reduction of ER stress in the TM with sodium 4-phenylbutyrate prevented dexamethasone-induced ocular hypertension in WT mice.	dexamethasone	ocular hypertension	24691439	1
-Furthermore, reduction of ER stress in the TM with sodium 4-phenylbutyrate prevented dexamethasone-induced ocular hypertension in WT mice.	sodium 4-phenylbutyrate	ocular hypertension	24691439	-1
-Detailed history obtained retrospectively revealed that the patient took zolmitriptan sparingly only when she had migraines.	zolmitriptan	migraines	24100257	-1
-In the first, cobalt cardiomyopathy was induced in eight dogs; VIP (by radioimmunoassay) decreased from 35 +/-	cobalt	cardiomyopathy	3711722	1
-ANIMALS: 12 cats suspected to have idiopathic epilepsy that was poorly controlled with phenobarbital or that had unacceptable adverse effects when treated with phenobarbital.	phenobarbital	idiopathic epilepsy	18341442	-1
-ANIMALS: 12 cats suspected to have idiopathic epilepsy that was poorly controlled with phenobarbital or that had unacceptable adverse effects when treated with phenobarbital.	phenobarbital	idiopathic epilepsy	18341442	-1
-RESULTS: Our patient was admitted to the MICU after being found unresponsive with presumed toxicity from acetaminophen which was ingested over a 2-day period.	acetaminophen	toxicity	19728177	-1
-CONCLUSION: Testosterone administration ameliorates STZ- and castration-induced memory impairment in male Wistar rats.	Testosterone	memory impairment	24902786	-1
-Because caffeine is an adenosine receptor antagonist, these results suggest that some panic disorder patients may have abnormalities in neuronal systems involving adenosine.	adenosine	panic disorder	2983630	-1
-Because caffeine is an adenosine receptor antagonist, these results suggest that some panic disorder patients may have abnormalities in neuronal systems involving adenosine.	adenosine	panic disorder	2983630	-1
-Because caffeine is an adenosine receptor antagonist, these results suggest that some panic disorder patients may have abnormalities in neuronal systems involving adenosine.	caffeine	panic disorder	2983630	-1
-Ocular motility changes after subtenon carboplatin chemotherapy for retinoblastoma.	carboplatin	retinoblastoma	12912689	-1
-Selectivity for the cerebrovascular bed makes nimodipine potentially useful in the treatment of subarachnoid hemorrhage, migraine headache, dementia, and stroke.	nimodipine	subarachnoid hemorrhage	3323259	-1
-Selectivity for the cerebrovascular bed makes nimodipine potentially useful in the treatment of subarachnoid hemorrhage, migraine headache, dementia, and stroke.	nimodipine	migraine headache	3323259	-1
-Selectivity for the cerebrovascular bed makes nimodipine potentially useful in the treatment of subarachnoid hemorrhage, migraine headache, dementia, and stroke.	nimodipine	stroke	3323259	-1
-Selectivity for the cerebrovascular bed makes nimodipine potentially useful in the treatment of subarachnoid hemorrhage, migraine headache, dementia, and stroke.	nimodipine	dementia	3323259	-1
-The studies suggest that propranolol is a useful drug in selected patients with severe idiopathic orthostatic hypotension.	propranolol	idiopathic orthostatic hypotension	611664	-1
-BACKGROUND: Focal subtenon carboplatin injections have recently been used as a presumably toxicity-free adjunct to systemic chemotherapy for intraocular retinoblastoma. OBJECTIVE: To report our clinical experience with abnormal ocular motility in patients treated with subtenon carboplatin chemotherapy.	carboplatin	abnormal ocular motility	12912689	1
-BACKGROUND: Focal subtenon carboplatin injections have recently been used as a presumably toxicity-free adjunct to systemic chemotherapy for intraocular retinoblastoma. OBJECTIVE: To report our clinical experience with abnormal ocular motility in patients treated with subtenon carboplatin chemotherapy.	carboplatin	toxicity	12912689	-1
-BACKGROUND: Focal subtenon carboplatin injections have recently been used as a presumably toxicity-free adjunct to systemic chemotherapy for intraocular retinoblastoma. OBJECTIVE: To report our clinical experience with abnormal ocular motility in patients treated with subtenon carboplatin chemotherapy.	carboplatin	intraocular retinoblastoma	12912689	-1
-BACKGROUND: Focal subtenon carboplatin injections have recently been used as a presumably toxicity-free adjunct to systemic chemotherapy for intraocular retinoblastoma. OBJECTIVE: To report our clinical experience with abnormal ocular motility in patients treated with subtenon carboplatin chemotherapy.	carboplatin	abnormal ocular motility	12912689	1
-BACKGROUND: Focal subtenon carboplatin injections have recently been used as a presumably toxicity-free adjunct to systemic chemotherapy for intraocular retinoblastoma. OBJECTIVE: To report our clinical experience with abnormal ocular motility in patients treated with subtenon carboplatin chemotherapy.	carboplatin	toxicity	12912689	-1
-BACKGROUND: Focal subtenon carboplatin injections have recently been used as a presumably toxicity-free adjunct to systemic chemotherapy for intraocular retinoblastoma. OBJECTIVE: To report our clinical experience with abnormal ocular motility in patients treated with subtenon carboplatin chemotherapy.	carboplatin	intraocular retinoblastoma	12912689	-1
-Overexpression of copper/zinc-superoxide dismutase protects from kanamycin-induced hearing loss.	zinc-superoxide	hearing loss	11474137	-1
-Children are particularly sensitive to DOX-induced heart failure.	DOX	heart failure	24812279	1
-METHODS: We noted abnormal ocular motility in 10 consecutive patients with retinoblastoma who had received subtenon carboplatin.	carboplatin	abnormal ocular motility	12912689	1
-METHODS: We noted abnormal ocular motility in 10 consecutive patients with retinoblastoma who had received subtenon carboplatin.	carboplatin	retinoblastoma	12912689	-1
-The abolition of muscle fasciculations (by 0.075mg/kg dose of Fazadinium) did not influence the occurrence of scoline pain.	Fazadinium	muscle fasciculations	7176945	-1
-The abolition of muscle fasciculations (by 0.075mg/kg dose of Fazadinium) did not influence the occurrence of scoline pain.	Fazadinium	pain	7176945	-1
-Cotrimoxazole, metronidazole, and erythromycin were involved in 15 reported manic episodes.	erythromycin	manic	11799346	1
-Suxamethonium-induced jaw stiffness and myalgia associated with atypical cholinesterase: case report.	Suxamethonium	jaw stiffness	7378868	-1
-RESULTS: Limitation of ocular motility was detected in all 12 eyes of 10 patients treated for intraocular retinoblastoma with 1 to 6 injections of subtenon carboplatin as part of multimodality therapy.	carboplatin	ocular motility	12912689	1
-RESULTS: Limitation of ocular motility was detected in all 12 eyes of 10 patients treated for intraocular retinoblastoma with 1 to 6 injections of subtenon carboplatin as part of multimodality therapy.	carboplatin	intraocular retinoblastoma	12912689	-1
-Cases reported by the FDA showed clarithromycin and ciprofloxacin to be the most frequently associated with the development of mania.	ciprofloxacin	mania	11799346	1
-Cases reported by the FDA showed clarithromycin and ciprofloxacin to be the most frequently associated with the development of mania.	clarithromycin	mania	11799346	1
-Cases reported by the FDA showed clarithromycin and ciprofloxacin to be the most frequently associated with the development of mania.	FDA	mania	11799346	-1
-Curcumin prevents maleate-induced nephrotoxicity: relation to hemodynamic alterations, oxidative stress, mitochondrial oxygen consumption and activity of respiratory complex I. The potential protective effect of the dietary antioxidant curcumin (120 mg/Kg/day for 6 days) against the renal injury induced by maleate was evaluated.	oxygen	nephrotoxicity	25119790	-1
-Curcumin prevents maleate-induced nephrotoxicity: relation to hemodynamic alterations, oxidative stress, mitochondrial oxygen consumption and activity of respiratory complex I. The potential protective effect of the dietary antioxidant curcumin (120 mg/Kg/day for 6 days) against the renal injury induced by maleate was evaluated.	oxygen	renal injury	25119790	-1
-Curcumin prevents maleate-induced nephrotoxicity: relation to hemodynamic alterations, oxidative stress, mitochondrial oxygen consumption and activity of respiratory complex I. The potential protective effect of the dietary antioxidant curcumin (120 mg/Kg/day for 6 days) against the renal injury induced by maleate was evaluated.	maleate	nephrotoxicity	25119790	-1
-Curcumin prevents maleate-induced nephrotoxicity: relation to hemodynamic alterations, oxidative stress, mitochondrial oxygen consumption and activity of respiratory complex I. The potential protective effect of the dietary antioxidant curcumin (120 mg/Kg/day for 6 days) against the renal injury induced by maleate was evaluated.	maleate	renal injury	25119790	-1
-Curcumin prevents maleate-induced nephrotoxicity: relation to hemodynamic alterations, oxidative stress, mitochondrial oxygen consumption and activity of respiratory complex I. The potential protective effect of the dietary antioxidant curcumin (120 mg/Kg/day for 6 days) against the renal injury induced by maleate was evaluated.	maleate	nephrotoxicity	25119790	-1
-Curcumin prevents maleate-induced nephrotoxicity: relation to hemodynamic alterations, oxidative stress, mitochondrial oxygen consumption and activity of respiratory complex I. The potential protective effect of the dietary antioxidant curcumin (120 mg/Kg/day for 6 days) against the renal injury induced by maleate was evaluated.	maleate	renal injury	25119790	-1
-Curcumin prevents maleate-induced nephrotoxicity: relation to hemodynamic alterations, oxidative stress, mitochondrial oxygen consumption and activity of respiratory complex I. The potential protective effect of the dietary antioxidant curcumin (120 mg/Kg/day for 6 days) against the renal injury induced by maleate was evaluated.	Curcumin	nephrotoxicity	25119790	-1
-Curcumin prevents maleate-induced nephrotoxicity: relation to hemodynamic alterations, oxidative stress, mitochondrial oxygen consumption and activity of respiratory complex I. The potential protective effect of the dietary antioxidant curcumin (120 mg/Kg/day for 6 days) against the renal injury induced by maleate was evaluated.	Curcumin	renal injury	25119790	-1
-Curcumin prevents maleate-induced nephrotoxicity: relation to hemodynamic alterations, oxidative stress, mitochondrial oxygen consumption and activity of respiratory complex I. The potential protective effect of the dietary antioxidant curcumin (120 mg/Kg/day for 6 days) against the renal injury induced by maleate was evaluated.	curcumin	nephrotoxicity	25119790	-1
-Curcumin prevents maleate-induced nephrotoxicity: relation to hemodynamic alterations, oxidative stress, mitochondrial oxygen consumption and activity of respiratory complex I. The potential protective effect of the dietary antioxidant curcumin (120 mg/Kg/day for 6 days) against the renal injury induced by maleate was evaluated.	curcumin	renal injury	25119790	-1
-CONCLUSIONS: These results suggest that bupivacaine stimulates COX-2 gene expression after tissue injury, which is associated with higher PGE2 production and pain after the local anesthetic effect dissipates.	PGE2	pain	18165598	-1
-CONCLUSIONS: These results suggest that bupivacaine stimulates COX-2 gene expression after tissue injury, which is associated with higher PGE2 production and pain after the local anesthetic effect dissipates.	bupivacaine	pain	18165598	-1
-CONCLUSIONS: Subtenon carboplatin chemotherapy is associated with significant fibrosis of orbital soft tissues, leading to mechanical restriction of eye movements and making subsequent enucleation difficult.	carboplatin	fibrosis	12912689	1
-Subtenon carboplatin is not free of toxicity, and its use is best restricted to specific indications.	carboplatin	toxicity	12912689	-1
-A case of oral penicillin anaphylaxis is described, and the terminology, occurrence, clinical manifestations, pathogenesis, prevention, and treatment of anaphylaxis are reviewed.	penicillin	anaphylaxis	3083835	1
-A case of oral penicillin anaphylaxis is described, and the terminology, occurrence, clinical manifestations, pathogenesis, prevention, and treatment of anaphylaxis are reviewed.	penicillin	anaphylaxis	3083835	1
-Piperacillin/tazobactam-induced seizure rapidly reversed by high flux hemodialysis in a patient on peritoneal dialysis.	tazobactam	seizure	17496739	-1
-Piperacillin/tazobactam-induced seizure rapidly reversed by high flux hemodialysis in a patient on peritoneal dialysis.	Piperacillin	seizure	17496739	-1
-Compared to wild-type mice, treatment of PPARalpha-/- mice with amiodarone resulted in an increased rate and extent of total body weight loss.	amiodarone	weight loss	15265979	-1
-Compared to wild-type mice, treatment of PPARalpha-/- mice with amiodarone resulted in an increased rate and extent of total body weight loss.	PPARalpha-/-	weight loss	15265979	-1
-Low functional programming of renal AT2R mediates the developmental origin of glomerulosclerosis in adult offspring induced by prenatal caffeine exposure.	caffeine	glomerulosclerosis	25986755	-1
-Anti-thyroid drugs, like carbimazole and propylthiouracil (PTU) are commonly prescribed for the treatment of hyperthyroidism.	propylthiouracil	hyperthyroidism	19263707	-1
-Anti-thyroid drugs, like carbimazole and propylthiouracil (PTU) are commonly prescribed for the treatment of hyperthyroidism.	PTU	hyperthyroidism	19263707	-1
-Anti-thyroid drugs, like carbimazole and propylthiouracil (PTU) are commonly prescribed for the treatment of hyperthyroidism.	carbimazole	hyperthyroidism	19263707	-1
-Thus, the precipitating cause of convulsions was believed to be an overdose of TNA.	TNA	convulsions	24434397	-1
-Thus, the precipitating cause of convulsions was believed to be an overdose of TNA.	TNA	overdose	24434397	-1
-(P < .01) at 3 min after ISO infusion with stenosis.	ISO	stenosis	8819482	-1
-We therefore hypothesized that overexpression of Cu/Zn-superoxide dismutase (h-SOD1) should protect transgenic mice from ototoxicity.	Zn-superoxide	ototoxicity	11474137	-1
-Although with current ulcer therapy (H-2 blockers, omeprazole, and sucralfate), the frequency of milk-alkali syndrome has decreased significantly, the classic triad of hypercalcemia, alkalosis, and renal impairment remains the hallmark of the syndrome.	sucralfate	milk-alkali syndrome	8667442	-1
-Although with current ulcer therapy (H-2 blockers, omeprazole, and sucralfate), the frequency of milk-alkali syndrome has decreased significantly, the classic triad of hypercalcemia, alkalosis, and renal impairment remains the hallmark of the syndrome.	sucralfate	hypercalcemia	8667442	-1
-Although with current ulcer therapy (H-2 blockers, omeprazole, and sucralfate), the frequency of milk-alkali syndrome has decreased significantly, the classic triad of hypercalcemia, alkalosis, and renal impairment remains the hallmark of the syndrome.	sucralfate	alkalosis	8667442	-1
-Although with current ulcer therapy (H-2 blockers, omeprazole, and sucralfate), the frequency of milk-alkali syndrome has decreased significantly, the classic triad of hypercalcemia, alkalosis, and renal impairment remains the hallmark of the syndrome.	sucralfate	renal impairment remains the hallmark of the syndrome	8667442	-1
-Although with current ulcer therapy (H-2 blockers, omeprazole, and sucralfate), the frequency of milk-alkali syndrome has decreased significantly, the classic triad of hypercalcemia, alkalosis, and renal impairment remains the hallmark of the syndrome.	sucralfate	ulcer	8667442	-1
-Although with current ulcer therapy (H-2 blockers, omeprazole, and sucralfate), the frequency of milk-alkali syndrome has decreased significantly, the classic triad of hypercalcemia, alkalosis, and renal impairment remains the hallmark of the syndrome.	omeprazole	milk-alkali syndrome	8667442	-1
-Although with current ulcer therapy (H-2 blockers, omeprazole, and sucralfate), the frequency of milk-alkali syndrome has decreased significantly, the classic triad of hypercalcemia, alkalosis, and renal impairment remains the hallmark of the syndrome.	omeprazole	hypercalcemia	8667442	-1
-Although with current ulcer therapy (H-2 blockers, omeprazole, and sucralfate), the frequency of milk-alkali syndrome has decreased significantly, the classic triad of hypercalcemia, alkalosis, and renal impairment remains the hallmark of the syndrome.	omeprazole	alkalosis	8667442	-1
-Although with current ulcer therapy (H-2 blockers, omeprazole, and sucralfate), the frequency of milk-alkali syndrome has decreased significantly, the classic triad of hypercalcemia, alkalosis, and renal impairment remains the hallmark of the syndrome.	omeprazole	renal impairment remains the hallmark of the syndrome	8667442	-1
-Although with current ulcer therapy (H-2 blockers, omeprazole, and sucralfate), the frequency of milk-alkali syndrome has decreased significantly, the classic triad of hypercalcemia, alkalosis, and renal impairment remains the hallmark of the syndrome.	omeprazole	ulcer	8667442	-1
-We report a patient with Graves' disease who developed ANCA positive carbimazole induced vasculitis.	carbimazole	vasculitis	19263707	-1
-We report a patient with Graves' disease who developed ANCA positive carbimazole induced vasculitis.	carbimazole	Graves' disease	19263707	-1
-Although the patient's renal function was not highly impaired and the dose of pilsicainide was low, the plasma concentration of pilsicainide may have been high, which can produce torsades de pointes in the octogenarian.	pilsicainide	torsades de pointes	24653743	1
-Control experiments indicated that neither an increase in pain sensitivity (pre-training naloxone) nor an induced aversive state (post-training naloxone) appear to be responsible for the influence of naloxone on the scopolamine-induced retention deficit.	scopolamine	pain	3088653	-1
-Control experiments indicated that neither an increase in pain sensitivity (pre-training naloxone) nor an induced aversive state (post-training naloxone) appear to be responsible for the influence of naloxone on the scopolamine-induced retention deficit.	scopolamine	retention deficit	3088653	-1
-Control experiments indicated that neither an increase in pain sensitivity (pre-training naloxone) nor an induced aversive state (post-training naloxone) appear to be responsible for the influence of naloxone on the scopolamine-induced retention deficit.	naloxone	pain	3088653	-1
-Control experiments indicated that neither an increase in pain sensitivity (pre-training naloxone) nor an induced aversive state (post-training naloxone) appear to be responsible for the influence of naloxone on the scopolamine-induced retention deficit.	naloxone	retention deficit	3088653	-1
-Control experiments indicated that neither an increase in pain sensitivity (pre-training naloxone) nor an induced aversive state (post-training naloxone) appear to be responsible for the influence of naloxone on the scopolamine-induced retention deficit.	naloxone	pain	3088653	-1
-Control experiments indicated that neither an increase in pain sensitivity (pre-training naloxone) nor an induced aversive state (post-training naloxone) appear to be responsible for the influence of naloxone on the scopolamine-induced retention deficit.	naloxone	retention deficit	3088653	-1
-Control experiments indicated that neither an increase in pain sensitivity (pre-training naloxone) nor an induced aversive state (post-training naloxone) appear to be responsible for the influence of naloxone on the scopolamine-induced retention deficit.	naloxone	pain	3088653	-1
-Control experiments indicated that neither an increase in pain sensitivity (pre-training naloxone) nor an induced aversive state (post-training naloxone) appear to be responsible for the influence of naloxone on the scopolamine-induced retention deficit.	naloxone	retention deficit	3088653	-1
-Seizure frequencies before and after initiation of levetiracetam treatment were compared, and adverse effects were recorded.	levetiracetam	Seizure	18341442	-1
-After recovery of his renal function, we could safely treat the patient with HD-MTX therapy by controlling drainage from ileostoma with total parenteral nutrition.	MTX	HD	20009434	-1
-Despite popular use of piperacillin, the dire neurotoxicity associated with piperacillin still goes unrecognized, leading to a delay in appropriate management.	piperacillin	neurotoxicity	17496739	-1
-Despite popular use of piperacillin, the dire neurotoxicity associated with piperacillin still goes unrecognized, leading to a delay in appropriate management.	piperacillin	neurotoxicity	17496739	-1
-This study investigates the role of ILK in liver enlargement induced by phenobarbital (PB).	phenobarbital	liver enlargement	19920070	1
-This study investigates the role of ILK in liver enlargement induced by phenobarbital (PB).	PB	liver enlargement	19920070	1
-DATA SYNTHESIS: New evidence from 1 good-quality RCT, 1 good-quality meta-analysis, and 2 fair-quality subanalyses of RCTs demonstrates that aspirin use reduces the number of CVD events in patients without known CVD.	aspirin	CVD	19293073	-1
-DATA SYNTHESIS: New evidence from 1 good-quality RCT, 1 good-quality meta-analysis, and 2 fair-quality subanalyses of RCTs demonstrates that aspirin use reduces the number of CVD events in patients without known CVD.	aspirin	CVD	19293073	-1
-Our aim was to observe if patients with panic disorder (PD) and patients with major depression with panic attacks (MDP) (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria) respond in a similar way to the induction of panic attacks by an oral caffeine challenge test.	caffeine	Mental Disorders	17445520	-1
-Our aim was to observe if patients with panic disorder (PD) and patients with major depression with panic attacks (MDP) (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria) respond in a similar way to the induction of panic attacks by an oral caffeine challenge test.	caffeine	major depression	17445520	-1
-Our aim was to observe if patients with panic disorder (PD) and patients with major depression with panic attacks (MDP) (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria) respond in a similar way to the induction of panic attacks by an oral caffeine challenge test.	caffeine	MDP	17445520	-1
-Our aim was to observe if patients with panic disorder (PD) and patients with major depression with panic attacks (MDP) (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria) respond in a similar way to the induction of panic attacks by an oral caffeine challenge test.	caffeine	panic disorder	17445520	1
-Our aim was to observe if patients with panic disorder (PD) and patients with major depression with panic attacks (MDP) (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria) respond in a similar way to the induction of panic attacks by an oral caffeine challenge test.	caffeine	PD	17445520	1
-Our aim was to observe if patients with panic disorder (PD) and patients with major depression with panic attacks (MDP) (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria) respond in a similar way to the induction of panic attacks by an oral caffeine challenge test.	caffeine	panic attacks	17445520	1
-Our aim was to observe if patients with panic disorder (PD) and patients with major depression with panic attacks (MDP) (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria) respond in a similar way to the induction of panic attacks by an oral caffeine challenge test.	caffeine	panic attacks	17445520	1
-Initial evaluation confirmed FHF from acetaminophen and cerebral edema.	acetaminophen	cerebral edema	19728177	1
-Initial evaluation confirmed FHF from acetaminophen and cerebral edema.	acetaminophen	FHF	19728177	-1
-Genetic separation of tumor growth and hemorrhagic phenotypes in an estrogen-induced tumor.	estrogen	tumor	8755612	-1
-Genetic separation of tumor growth and hemorrhagic phenotypes in an estrogen-induced tumor.	estrogen	tumor	8755612	-1
-Genetic separation of tumor growth and hemorrhagic phenotypes in an estrogen-induced tumor.	estrogen	hemorrhagic	8755612	-1
-The ED50 values for morphine when given in combination with CNSB002 (5 mg/kg) were less than the maximum nonsedating dose: 0.56 (1.55) in the carrageenan model and 1.37 (1.23) in the neuropathy model (mg/kg; mean, SEM).	CNSB002	neuropathy	20447294	-1
-The ED50 values for morphine when given in combination with CNSB002 (5 mg/kg) were less than the maximum nonsedating dose: 0.56 (1.55) in the carrageenan model and 1.37 (1.23) in the neuropathy model (mg/kg; mean, SEM).	morphine	neuropathy	20447294	-1
-The ED50 values for morphine when given in combination with CNSB002 (5 mg/kg) were less than the maximum nonsedating dose: 0.56 (1.55) in the carrageenan model and 1.37 (1.23) in the neuropathy model (mg/kg; mean, SEM).	carrageenan	neuropathy	20447294	-1
-Rate of YMDD motif mutants in lamivudine-untreated Iranian patients with chronic hepatitis B virus infection.	lamivudine	chronic hepatitis B virus infection	17954033	-1
-0.06 mL/min/100 g of body weight in untreated PAN nephropathy animals, p < 0.05.	PAN	nephropathy	8825380	1
-Barium-supplemented Long-Evans hooded rats were characterized by a persistent hypertension that was evident after 1 month of barium (100 micrograms/ml mineral fortified water) treatment.	Barium	hypertension	3975902	-1
-Barium-supplemented Long-Evans hooded rats were characterized by a persistent hypertension that was evident after 1 month of barium (100 micrograms/ml mineral fortified water) treatment.	barium	hypertension	3975902	-1
-In order to identify risk factors associated with the development of hypercalcemia, indirect parameters of intestinal calcium reabsorption and bone turnover rate in these 14 patients were compared with results in 14 eucalcemic patients matched for age, sex, length of time on dialysis, and etiology of renal disease.	calcium	hypercalcemia	2239937	-1
-In order to identify risk factors associated with the development of hypercalcemia, indirect parameters of intestinal calcium reabsorption and bone turnover rate in these 14 patients were compared with results in 14 eucalcemic patients matched for age, sex, length of time on dialysis, and etiology of renal disease.	calcium	renal disease	2239937	-1
-We report a 57-year-old woman with end-stage renal disease receiving continuous ambulatory peritoneal dialysis (CAPD), who developed slurred speech, tremor, bizarre behavior, progressive mental confusion, and 2 episodes of generalized tonic-clonic seizure (GTCS) after 5 doses of piperacillin/tazobactam (2 g/250 mg) were given for bronchiectasis with secondary infection.	piperacillin/tazobactam	bronchiectasis	17496739	-1
-We report a 57-year-old woman with end-stage renal disease receiving continuous ambulatory peritoneal dialysis (CAPD), who developed slurred speech, tremor, bizarre behavior, progressive mental confusion, and 2 episodes of generalized tonic-clonic seizure (GTCS) after 5 doses of piperacillin/tazobactam (2 g/250 mg) were given for bronchiectasis with secondary infection.	piperacillin/tazobactam	infection	17496739	-1
-We report a 57-year-old woman with end-stage renal disease receiving continuous ambulatory peritoneal dialysis (CAPD), who developed slurred speech, tremor, bizarre behavior, progressive mental confusion, and 2 episodes of generalized tonic-clonic seizure (GTCS) after 5 doses of piperacillin/tazobactam (2 g/250 mg) were given for bronchiectasis with secondary infection.	piperacillin/tazobactam	tremor	17496739	1
-We report a 57-year-old woman with end-stage renal disease receiving continuous ambulatory peritoneal dialysis (CAPD), who developed slurred speech, tremor, bizarre behavior, progressive mental confusion, and 2 episodes of generalized tonic-clonic seizure (GTCS) after 5 doses of piperacillin/tazobactam (2 g/250 mg) were given for bronchiectasis with secondary infection.	piperacillin/tazobactam	end-stage renal disease	17496739	-1
-We report a 57-year-old woman with end-stage renal disease receiving continuous ambulatory peritoneal dialysis (CAPD), who developed slurred speech, tremor, bizarre behavior, progressive mental confusion, and 2 episodes of generalized tonic-clonic seizure (GTCS) after 5 doses of piperacillin/tazobactam (2 g/250 mg) were given for bronchiectasis with secondary infection.	piperacillin/tazobactam	tonic-clonic seizure	17496739	1
-Oral galactose exposure might have beneficial effects on learning and memory ability and could be worth investigating for improvement of cognitive deficits associated with glucose hypometabolism in AD.	galactose	AD	24055495	-1
-Oral galactose exposure might have beneficial effects on learning and memory ability and could be worth investigating for improvement of cognitive deficits associated with glucose hypometabolism in AD.	galactose	cognitive deficits	24055495	1
-Oral galactose exposure might have beneficial effects on learning and memory ability and could be worth investigating for improvement of cognitive deficits associated with glucose hypometabolism in AD.	galactose	glucose hypometabolism	24055495	-1
-A 45-year-old man, with a 10-year history of manic depression treated with lithium, was admitted with hyperosmolar, nonketotic coma.	lithium	manic depression	9538487	-1
-A 45-year-old man, with a 10-year history of manic depression treated with lithium, was admitted with hyperosmolar, nonketotic coma.	lithium	coma	9538487	-1
-OBJECTIVE: The authors compared 4-month treatment outcomes for olanzapine versus risperidone in patients with first-episode schizophrenia spectrum disorders.	risperidone	schizophrenia spectrum disorders	17151160	-1
-OBJECTIVE: The authors compared 4-month treatment outcomes for olanzapine versus risperidone in patients with first-episode schizophrenia spectrum disorders.	olanzapine	schizophrenia spectrum disorders	17151160	-1
-CONCLUSION: In patients with FHF and cerebral edema from acetaminophen overdose, prolonged therapeutic hypothermia could potentially be used as a life saving therapy and a bridge to hepatic and neurological recovery.	acetaminophen	hypothermia	19728177	-1
-CONCLUSION: In patients with FHF and cerebral edema from acetaminophen overdose, prolonged therapeutic hypothermia could potentially be used as a life saving therapy and a bridge to hepatic and neurological recovery.	acetaminophen	overdose	19728177	-1
-CONCLUSION: In patients with FHF and cerebral edema from acetaminophen overdose, prolonged therapeutic hypothermia could potentially be used as a life saving therapy and a bridge to hepatic and neurological recovery.	acetaminophen	FHF	19728177	-1
-The increases in anxiety and depression are in line with previous observations in recreational ecstasy-polydrug users. Dysregulated diurnal cortisol may be indicative of inappropriate anticipation of forthcoming demands and hypersecretion may lead to the increased psychological and physical morbidity associated with heavy recreational use of ecstasy.	ecstasy	anxiety	24190587	-1
-The increases in anxiety and depression are in line with previous observations in recreational ecstasy-polydrug users. Dysregulated diurnal cortisol may be indicative of inappropriate anticipation of forthcoming demands and hypersecretion may lead to the increased psychological and physical morbidity associated with heavy recreational use of ecstasy.	ecstasy	anxiety	24190587	-1
-The increases in anxiety and depression are in line with previous observations in recreational ecstasy-polydrug users. Dysregulated diurnal cortisol may be indicative of inappropriate anticipation of forthcoming demands and hypersecretion may lead to the increased psychological and physical morbidity associated with heavy recreational use of ecstasy.	cortisol	anxiety	24190587	-1
-The increases in anxiety and depression are in line with previous observations in recreational ecstasy-polydrug users. Dysregulated diurnal cortisol may be indicative of inappropriate anticipation of forthcoming demands and hypersecretion may lead to the increased psychological and physical morbidity associated with heavy recreational use of ecstasy.	cortisol	depression	24190587	-1
-Losartan reduced uraemia and increased urea clearance in advanced ADR nephropathy in SHR.	ADR	nephropathy	18987260	-1
-Losartan reduced uraemia and increased urea clearance in advanced ADR nephropathy in SHR.	urea	nephropathy	18987260	-1
-Losartan reduced uraemia and increased urea clearance in advanced ADR nephropathy in SHR.	Losartan	nephropathy	18987260	-1
-A total of 115 patients with a DSM-IV diagnosis of bipolar disorder, manic or mixed, were randomized to olanzapine, 5 to 20 mg/d (n = 55), or placebo (n = 60).	olanzapine	bipolar disorder	10986547	-1
-A total of 115 patients with a DSM-IV diagnosis of bipolar disorder, manic or mixed, were randomized to olanzapine, 5 to 20 mg/d (n = 55), or placebo (n = 60).	olanzapine	manic	10986547	-1
-Histamine antagonists and d-tubocurarine-induced hypotension in cardiac surgical patients.	Histamine	hypotension	2429800	-1
-Caffeine produced significantly greater increases in subject-rated anxiety, nervousness, fear, nausea, palpitations, restlessness, and tremors in the patients compared with healthy subjects.	Caffeine	anxiety	2983630	1
-Caffeine produced significantly greater increases in subject-rated anxiety, nervousness, fear, nausea, palpitations, restlessness, and tremors in the patients compared with healthy subjects.	Caffeine	nausea	2983630	1
-BACKGROUND: Lamivudine is used for the treatment of chronic hepatitis B patients.	Lamivudine	hepatitis B	17954033	-1
-We aimed to compare the risks of hospitalization for AMI and GI bleeding among elderly patients using COX-2 inhibitors, NS-NSAIDs and acetaminophen.	acetaminophen	AMI	17255138	-1
-We aimed to compare the risks of hospitalization for AMI and GI bleeding among elderly patients using COX-2 inhibitors, NS-NSAIDs and acetaminophen.	acetaminophen	GI bleeding	17255138	-1
-Anaesthesia with a propofol infusion and avoidance of serotonin antagonists provided a nausea-free postoperative course without exacerbation of the depression disorder.	propofol	nausea	9323412	-1
-Anaesthesia with a propofol infusion and avoidance of serotonin antagonists provided a nausea-free postoperative course without exacerbation of the depression disorder.	propofol	depression disorder	9323412	-1
-Anaesthesia with a propofol infusion and avoidance of serotonin antagonists provided a nausea-free postoperative course without exacerbation of the depression disorder.	serotonin	nausea	9323412	-1
-Anaesthesia with a propofol infusion and avoidance of serotonin antagonists provided a nausea-free postoperative course without exacerbation of the depression disorder.	serotonin	depression disorder	9323412	-1
-Median seizure frequency prior to treatment with levetiracetam (2.1 seizures/mo) was significantly higher than median seizure frequency after initiation of levetiracetam treatment (0.42 seizures/mo), and 7 of 10 cats were classified as having responded to levetiracetam treatment (ie, reduction in seizure frequency of >or=50%).	levetiracetam	seizure	18341442	-1
-Median seizure frequency prior to treatment with levetiracetam (2.1 seizures/mo) was significantly higher than median seizure frequency after initiation of levetiracetam treatment (0.42 seizures/mo), and 7 of 10 cats were classified as having responded to levetiracetam treatment (ie, reduction in seizure frequency of >or=50%).	levetiracetam	seizures	18341442	-1
-Median seizure frequency prior to treatment with levetiracetam (2.1 seizures/mo) was significantly higher than median seizure frequency after initiation of levetiracetam treatment (0.42 seizures/mo), and 7 of 10 cats were classified as having responded to levetiracetam treatment (ie, reduction in seizure frequency of >or=50%).	levetiracetam	seizure	18341442	-1
-Median seizure frequency prior to treatment with levetiracetam (2.1 seizures/mo) was significantly higher than median seizure frequency after initiation of levetiracetam treatment (0.42 seizures/mo), and 7 of 10 cats were classified as having responded to levetiracetam treatment (ie, reduction in seizure frequency of >or=50%).	levetiracetam	seizures	18341442	-1
-Median seizure frequency prior to treatment with levetiracetam (2.1 seizures/mo) was significantly higher than median seizure frequency after initiation of levetiracetam treatment (0.42 seizures/mo), and 7 of 10 cats were classified as having responded to levetiracetam treatment (ie, reduction in seizure frequency of >or=50%).	levetiracetam	seizure	18341442	-1
-Median seizure frequency prior to treatment with levetiracetam (2.1 seizures/mo) was significantly higher than median seizure frequency after initiation of levetiracetam treatment (0.42 seizures/mo), and 7 of 10 cats were classified as having responded to levetiracetam treatment (ie, reduction in seizure frequency of >or=50%).	levetiracetam	seizure	18341442	-1
-Median seizure frequency prior to treatment with levetiracetam (2.1 seizures/mo) was significantly higher than median seizure frequency after initiation of levetiracetam treatment (0.42 seizures/mo), and 7 of 10 cats were classified as having responded to levetiracetam treatment (ie, reduction in seizure frequency of >or=50%).	levetiracetam	seizures	18341442	-1
-Median seizure frequency prior to treatment with levetiracetam (2.1 seizures/mo) was significantly higher than median seizure frequency after initiation of levetiracetam treatment (0.42 seizures/mo), and 7 of 10 cats were classified as having responded to levetiracetam treatment (ie, reduction in seizure frequency of >or=50%).	levetiracetam	seizure	18341442	-1
-Median seizure frequency prior to treatment with levetiracetam (2.1 seizures/mo) was significantly higher than median seizure frequency after initiation of levetiracetam treatment (0.42 seizures/mo), and 7 of 10 cats were classified as having responded to levetiracetam treatment (ie, reduction in seizure frequency of >or=50%).	levetiracetam	seizures	18341442	-1
-Median seizure frequency prior to treatment with levetiracetam (2.1 seizures/mo) was significantly higher than median seizure frequency after initiation of levetiracetam treatment (0.42 seizures/mo), and 7 of 10 cats were classified as having responded to levetiracetam treatment (ie, reduction in seizure frequency of >or=50%).	levetiracetam	seizure	18341442	-1
-Median seizure frequency prior to treatment with levetiracetam (2.1 seizures/mo) was significantly higher than median seizure frequency after initiation of levetiracetam treatment (0.42 seizures/mo), and 7 of 10 cats were classified as having responded to levetiracetam treatment (ie, reduction in seizure frequency of >or=50%).	levetiracetam	seizure	18341442	-1
-Median seizure frequency prior to treatment with levetiracetam (2.1 seizures/mo) was significantly higher than median seizure frequency after initiation of levetiracetam treatment (0.42 seizures/mo), and 7 of 10 cats were classified as having responded to levetiracetam treatment (ie, reduction in seizure frequency of >or=50%).	levetiracetam	seizures	18341442	-1
-Median seizure frequency prior to treatment with levetiracetam (2.1 seizures/mo) was significantly higher than median seizure frequency after initiation of levetiracetam treatment (0.42 seizures/mo), and 7 of 10 cats were classified as having responded to levetiracetam treatment (ie, reduction in seizure frequency of >or=50%).	levetiracetam	seizure	18341442	-1
-Median seizure frequency prior to treatment with levetiracetam (2.1 seizures/mo) was significantly higher than median seizure frequency after initiation of levetiracetam treatment (0.42 seizures/mo), and 7 of 10 cats were classified as having responded to levetiracetam treatment (ie, reduction in seizure frequency of >or=50%).	levetiracetam	seizures	18341442	-1
-Median seizure frequency prior to treatment with levetiracetam (2.1 seizures/mo) was significantly higher than median seizure frequency after initiation of levetiracetam treatment (0.42 seizures/mo), and 7 of 10 cats were classified as having responded to levetiracetam treatment (ie, reduction in seizure frequency of >or=50%).	levetiracetam	seizure	18341442	-1
-The laboratory data revealed normal plasma electrolyte and ammonia levels but leukocytosis.	ammonia	leukocytosis	17496739	-1
-CONCLUSION: Despite theoretical concerns that lidocaine may enhance cocaine toxicity, the use of lidocaine in patients with cocaine-associated MI was not associated with significant cardiovascular or central nervous system toxicity.	lidocaine	MI	7492040	-1
-CONCLUSION: Despite theoretical concerns that lidocaine may enhance cocaine toxicity, the use of lidocaine in patients with cocaine-associated MI was not associated with significant cardiovascular or central nervous system toxicity.	lidocaine	toxicity	7492040	-1
-CONCLUSION: Despite theoretical concerns that lidocaine may enhance cocaine toxicity, the use of lidocaine in patients with cocaine-associated MI was not associated with significant cardiovascular or central nervous system toxicity.	lidocaine	toxicity	7492040	-1
-CONCLUSION: Despite theoretical concerns that lidocaine may enhance cocaine toxicity, the use of lidocaine in patients with cocaine-associated MI was not associated with significant cardiovascular or central nervous system toxicity.	lidocaine	MI	7492040	-1
-CONCLUSION: Despite theoretical concerns that lidocaine may enhance cocaine toxicity, the use of lidocaine in patients with cocaine-associated MI was not associated with significant cardiovascular or central nervous system toxicity.	lidocaine	toxicity	7492040	-1
-CONCLUSION: Despite theoretical concerns that lidocaine may enhance cocaine toxicity, the use of lidocaine in patients with cocaine-associated MI was not associated with significant cardiovascular or central nervous system toxicity.	lidocaine	toxicity	7492040	-1
-CONCLUSION: Despite theoretical concerns that lidocaine may enhance cocaine toxicity, the use of lidocaine in patients with cocaine-associated MI was not associated with significant cardiovascular or central nervous system toxicity.	cocaine	MI	7492040	1
-CONCLUSION: Despite theoretical concerns that lidocaine may enhance cocaine toxicity, the use of lidocaine in patients with cocaine-associated MI was not associated with significant cardiovascular or central nervous system toxicity.	cocaine	toxicity	7492040	-1
-CONCLUSION: Despite theoretical concerns that lidocaine may enhance cocaine toxicity, the use of lidocaine in patients with cocaine-associated MI was not associated with significant cardiovascular or central nervous system toxicity.	cocaine	toxicity	7492040	-1
-CONCLUSION: Despite theoretical concerns that lidocaine may enhance cocaine toxicity, the use of lidocaine in patients with cocaine-associated MI was not associated with significant cardiovascular or central nervous system toxicity.	cocaine	toxicity	7492040	-1
-CONCLUSION: Despite theoretical concerns that lidocaine may enhance cocaine toxicity, the use of lidocaine in patients with cocaine-associated MI was not associated with significant cardiovascular or central nervous system toxicity.	cocaine	toxicity	7492040	-1
-The absence of induction of these genes as well as hepatomegaly in PPARalpha knockout [PPARalpha-/-] mice indicated that the effects of amiodarone were dependent upon the presence of a functional PPARalpha gene.	PPARalpha-/-	hepatomegaly	15265979	-1
-The absence of induction of these genes as well as hepatomegaly in PPARalpha knockout [PPARalpha-/-] mice indicated that the effects of amiodarone were dependent upon the presence of a functional PPARalpha gene.	PPARalpha	hepatomegaly	15265979	-1
-Vasodilation of large and small coronary vessels and hypotension induced by cromakalim and pinacidil were not affected by prior combined beta adrenergic and muscarinic receptors blockade but drug-induced tachycardia was abolished.	cromakalim	tachycardia	2173761	1
-Vasodilation of large and small coronary vessels and hypotension induced by cromakalim and pinacidil were not affected by prior combined beta adrenergic and muscarinic receptors blockade but drug-induced tachycardia was abolished.	pinacidil	tachycardia	2173761	1
-Vasodilation of large and small coronary vessels and hypotension induced by cromakalim and pinacidil were not affected by prior combined beta adrenergic and muscarinic receptors blockade but drug-induced tachycardia was abolished.	pinacidil	hypotension	2173761	1
-Among non-users of aspirin, the adjusted hazard ratios (95% confidence interval) of hospitalization for AMI/GI vs the acetaminophen (with no aspirin) group were: rofecoxib 1.27 (1.13, 1.42), celecoxib 0.93 (0.83, 1.03), naproxen 1.59 (1.31, 1.93), diclofenac 1.17 (0.99, 1.38) and ibuprofen 1.05 (0.74, 1.51).	naproxen	GI	17255138	-1
-Among non-users of aspirin, the adjusted hazard ratios (95% confidence interval) of hospitalization for AMI/GI vs the acetaminophen (with no aspirin) group were: rofecoxib 1.27 (1.13, 1.42), celecoxib 0.93 (0.83, 1.03), naproxen 1.59 (1.31, 1.93), diclofenac 1.17 (0.99, 1.38) and ibuprofen 1.05 (0.74, 1.51).	aspirin	GI	17255138	-1
-Among non-users of aspirin, the adjusted hazard ratios (95% confidence interval) of hospitalization for AMI/GI vs the acetaminophen (with no aspirin) group were: rofecoxib 1.27 (1.13, 1.42), celecoxib 0.93 (0.83, 1.03), naproxen 1.59 (1.31, 1.93), diclofenac 1.17 (0.99, 1.38) and ibuprofen 1.05 (0.74, 1.51).	aspirin	GI	17255138	-1
-Among non-users of aspirin, the adjusted hazard ratios (95% confidence interval) of hospitalization for AMI/GI vs the acetaminophen (with no aspirin) group were: rofecoxib 1.27 (1.13, 1.42), celecoxib 0.93 (0.83, 1.03), naproxen 1.59 (1.31, 1.93), diclofenac 1.17 (0.99, 1.38) and ibuprofen 1.05 (0.74, 1.51).	acetaminophen	GI	17255138	-1
-Among non-users of aspirin, the adjusted hazard ratios (95% confidence interval) of hospitalization for AMI/GI vs the acetaminophen (with no aspirin) group were: rofecoxib 1.27 (1.13, 1.42), celecoxib 0.93 (0.83, 1.03), naproxen 1.59 (1.31, 1.93), diclofenac 1.17 (0.99, 1.38) and ibuprofen 1.05 (0.74, 1.51).	ibuprofen	GI	17255138	-1
-Among non-users of aspirin, the adjusted hazard ratios (95% confidence interval) of hospitalization for AMI/GI vs the acetaminophen (with no aspirin) group were: rofecoxib 1.27 (1.13, 1.42), celecoxib 0.93 (0.83, 1.03), naproxen 1.59 (1.31, 1.93), diclofenac 1.17 (0.99, 1.38) and ibuprofen 1.05 (0.74, 1.51).	AMI	GI	17255138	-1
-Among non-users of aspirin, the adjusted hazard ratios (95% confidence interval) of hospitalization for AMI/GI vs the acetaminophen (with no aspirin) group were: rofecoxib 1.27 (1.13, 1.42), celecoxib 0.93 (0.83, 1.03), naproxen 1.59 (1.31, 1.93), diclofenac 1.17 (0.99, 1.38) and ibuprofen 1.05 (0.74, 1.51).	diclofenac	GI	17255138	-1
-Among non-users of aspirin, the adjusted hazard ratios (95% confidence interval) of hospitalization for AMI/GI vs the acetaminophen (with no aspirin) group were: rofecoxib 1.27 (1.13, 1.42), celecoxib 0.93 (0.83, 1.03), naproxen 1.59 (1.31, 1.93), diclofenac 1.17 (0.99, 1.38) and ibuprofen 1.05 (0.74, 1.51).	celecoxib	GI	17255138	-1
-Among non-users of aspirin, the adjusted hazard ratios (95% confidence interval) of hospitalization for AMI/GI vs the acetaminophen (with no aspirin) group were: rofecoxib 1.27 (1.13, 1.42), celecoxib 0.93 (0.83, 1.03), naproxen 1.59 (1.31, 1.93), diclofenac 1.17 (0.99, 1.38) and ibuprofen 1.05 (0.74, 1.51).	rofecoxib	GI	17255138	-1
-Recent studies show that the YMDD motif mutants (resistant hepatitis B virus) occur as natural genome variability in lamivudine-untreated chronic hepatitis B patients.	lamivudine	hepatitis B	17954033	-1
-Recent studies show that the YMDD motif mutants (resistant hepatitis B virus) occur as natural genome variability in lamivudine-untreated chronic hepatitis B patients.	lamivudine	hepatitis B	17954033	-1
-Among users of aspirin, they were: rofecoxib 1.73 (1.52, 1.98), celecoxib 1.34 (1.19, 1.52), ibuprofen 1.51 (0.95, 2.41), diclofenac 1.69 (1.35, 2.10), naproxen 1.35 (0.97, 1.88) and acetaminophen 1.29 (1.17, 1.42). CONCLUSION: Among non-users of aspirin, naproxen seemed to carry the highest risk for AMI/GI bleeding.	naproxen	GI bleeding	17255138	1
-Among users of aspirin, they were: rofecoxib 1.73 (1.52, 1.98), celecoxib 1.34 (1.19, 1.52), ibuprofen 1.51 (0.95, 2.41), diclofenac 1.69 (1.35, 2.10), naproxen 1.35 (0.97, 1.88) and acetaminophen 1.29 (1.17, 1.42). CONCLUSION: Among non-users of aspirin, naproxen seemed to carry the highest risk for AMI/GI bleeding.	naproxen	AMI	17255138	1
-Among users of aspirin, they were: rofecoxib 1.73 (1.52, 1.98), celecoxib 1.34 (1.19, 1.52), ibuprofen 1.51 (0.95, 2.41), diclofenac 1.69 (1.35, 2.10), naproxen 1.35 (0.97, 1.88) and acetaminophen 1.29 (1.17, 1.42). CONCLUSION: Among non-users of aspirin, naproxen seemed to carry the highest risk for AMI/GI bleeding.	naproxen	GI bleeding	17255138	1
-Among users of aspirin, they were: rofecoxib 1.73 (1.52, 1.98), celecoxib 1.34 (1.19, 1.52), ibuprofen 1.51 (0.95, 2.41), diclofenac 1.69 (1.35, 2.10), naproxen 1.35 (0.97, 1.88) and acetaminophen 1.29 (1.17, 1.42). CONCLUSION: Among non-users of aspirin, naproxen seemed to carry the highest risk for AMI/GI bleeding.	aspirin	AMI	17255138	-1
-Among users of aspirin, they were: rofecoxib 1.73 (1.52, 1.98), celecoxib 1.34 (1.19, 1.52), ibuprofen 1.51 (0.95, 2.41), diclofenac 1.69 (1.35, 2.10), naproxen 1.35 (0.97, 1.88) and acetaminophen 1.29 (1.17, 1.42). CONCLUSION: Among non-users of aspirin, naproxen seemed to carry the highest risk for AMI/GI bleeding.	aspirin	GI bleeding	17255138	-1
-Among users of aspirin, they were: rofecoxib 1.73 (1.52, 1.98), celecoxib 1.34 (1.19, 1.52), ibuprofen 1.51 (0.95, 2.41), diclofenac 1.69 (1.35, 2.10), naproxen 1.35 (0.97, 1.88) and acetaminophen 1.29 (1.17, 1.42). CONCLUSION: Among non-users of aspirin, naproxen seemed to carry the highest risk for AMI/GI bleeding.	aspirin	AMI	17255138	-1
-Among users of aspirin, they were: rofecoxib 1.73 (1.52, 1.98), celecoxib 1.34 (1.19, 1.52), ibuprofen 1.51 (0.95, 2.41), diclofenac 1.69 (1.35, 2.10), naproxen 1.35 (0.97, 1.88) and acetaminophen 1.29 (1.17, 1.42). CONCLUSION: Among non-users of aspirin, naproxen seemed to carry the highest risk for AMI/GI bleeding.	aspirin	GI bleeding	17255138	-1
-Among users of aspirin, they were: rofecoxib 1.73 (1.52, 1.98), celecoxib 1.34 (1.19, 1.52), ibuprofen 1.51 (0.95, 2.41), diclofenac 1.69 (1.35, 2.10), naproxen 1.35 (0.97, 1.88) and acetaminophen 1.29 (1.17, 1.42). CONCLUSION: Among non-users of aspirin, naproxen seemed to carry the highest risk for AMI/GI bleeding.	acetaminophen	AMI	17255138	-1
-Among users of aspirin, they were: rofecoxib 1.73 (1.52, 1.98), celecoxib 1.34 (1.19, 1.52), ibuprofen 1.51 (0.95, 2.41), diclofenac 1.69 (1.35, 2.10), naproxen 1.35 (0.97, 1.88) and acetaminophen 1.29 (1.17, 1.42). CONCLUSION: Among non-users of aspirin, naproxen seemed to carry the highest risk for AMI/GI bleeding.	acetaminophen	GI bleeding	17255138	-1
-Among users of aspirin, they were: rofecoxib 1.73 (1.52, 1.98), celecoxib 1.34 (1.19, 1.52), ibuprofen 1.51 (0.95, 2.41), diclofenac 1.69 (1.35, 2.10), naproxen 1.35 (0.97, 1.88) and acetaminophen 1.29 (1.17, 1.42). CONCLUSION: Among non-users of aspirin, naproxen seemed to carry the highest risk for AMI/GI bleeding.	diclofenac	AMI	17255138	-1
-Among users of aspirin, they were: rofecoxib 1.73 (1.52, 1.98), celecoxib 1.34 (1.19, 1.52), ibuprofen 1.51 (0.95, 2.41), diclofenac 1.69 (1.35, 2.10), naproxen 1.35 (0.97, 1.88) and acetaminophen 1.29 (1.17, 1.42). CONCLUSION: Among non-users of aspirin, naproxen seemed to carry the highest risk for AMI/GI bleeding.	diclofenac	GI bleeding	17255138	-1
-Among users of aspirin, they were: rofecoxib 1.73 (1.52, 1.98), celecoxib 1.34 (1.19, 1.52), ibuprofen 1.51 (0.95, 2.41), diclofenac 1.69 (1.35, 2.10), naproxen 1.35 (0.97, 1.88) and acetaminophen 1.29 (1.17, 1.42). CONCLUSION: Among non-users of aspirin, naproxen seemed to carry the highest risk for AMI/GI bleeding.	ibuprofen	AMI	17255138	-1
-Among users of aspirin, they were: rofecoxib 1.73 (1.52, 1.98), celecoxib 1.34 (1.19, 1.52), ibuprofen 1.51 (0.95, 2.41), diclofenac 1.69 (1.35, 2.10), naproxen 1.35 (0.97, 1.88) and acetaminophen 1.29 (1.17, 1.42). CONCLUSION: Among non-users of aspirin, naproxen seemed to carry the highest risk for AMI/GI bleeding.	ibuprofen	GI bleeding	17255138	-1
-Among users of aspirin, they were: rofecoxib 1.73 (1.52, 1.98), celecoxib 1.34 (1.19, 1.52), ibuprofen 1.51 (0.95, 2.41), diclofenac 1.69 (1.35, 2.10), naproxen 1.35 (0.97, 1.88) and acetaminophen 1.29 (1.17, 1.42). CONCLUSION: Among non-users of aspirin, naproxen seemed to carry the highest risk for AMI/GI bleeding.	celecoxib	AMI	17255138	-1
-Among users of aspirin, they were: rofecoxib 1.73 (1.52, 1.98), celecoxib 1.34 (1.19, 1.52), ibuprofen 1.51 (0.95, 2.41), diclofenac 1.69 (1.35, 2.10), naproxen 1.35 (0.97, 1.88) and acetaminophen 1.29 (1.17, 1.42). CONCLUSION: Among non-users of aspirin, naproxen seemed to carry the highest risk for AMI/GI bleeding.	celecoxib	GI bleeding	17255138	-1
-Among users of aspirin, they were: rofecoxib 1.73 (1.52, 1.98), celecoxib 1.34 (1.19, 1.52), ibuprofen 1.51 (0.95, 2.41), diclofenac 1.69 (1.35, 2.10), naproxen 1.35 (0.97, 1.88) and acetaminophen 1.29 (1.17, 1.42). CONCLUSION: Among non-users of aspirin, naproxen seemed to carry the highest risk for AMI/GI bleeding.	rofecoxib	AMI	17255138	1
-Toxic hepatitis induced by disulfiram in a non-alcoholic.	disulfiram	Toxic hepatitis	6453500	1
-The AMI/GI toxicity of celecoxib was similar to that of acetaminophen and seemed to be better than those of rofecoxib and NS-NSAIDs.	celecoxib	AMI	17255138	-1
-The AMI/GI toxicity of celecoxib was similar to that of acetaminophen and seemed to be better than those of rofecoxib and NS-NSAIDs.	celecoxib	GI toxicity	17255138	-1
-The AMI/GI toxicity of celecoxib was similar to that of acetaminophen and seemed to be better than those of rofecoxib and NS-NSAIDs.	acetaminophen	AMI	17255138	-1
-The AMI/GI toxicity of celecoxib was similar to that of acetaminophen and seemed to be better than those of rofecoxib and NS-NSAIDs.	acetaminophen	GI toxicity	17255138	-1
-The AMI/GI toxicity of celecoxib was similar to that of acetaminophen and seemed to be better than those of rofecoxib and NS-NSAIDs.	rofecoxib	AMI	17255138	1
-The AMI/GI toxicity of celecoxib was similar to that of acetaminophen and seemed to be better than those of rofecoxib and NS-NSAIDs.	rofecoxib	GI toxicity	17255138	-1
-Cluster analysis showed a random distribution of lesions in the PAN glomeruli in concordance with the random localization of mesangial areas with dysfunction in this model.	PAN	dysfunction	3990093	-1
-Histopathologically, typical findings were observed in the cerebella from the control groups, but the findings consistent with early embryonic development were noted in BCNU-exposed cortical dysplasia group.	BCNU	cortical dysplasia	17572393	1
-In a randomized double-blind experiment performed in 2 occasions 7 days apart, 480 mg caffeine and a caffeine-free (placebo) solution were administered in a coffee form and anxiety scales were applied before and after each test.	caffeine	anxiety	17445520	-1
-In a randomized double-blind experiment performed in 2 occasions 7 days apart, 480 mg caffeine and a caffeine-free (placebo) solution were administered in a coffee form and anxiety scales were applied before and after each test.	caffeine	anxiety	17445520	-1
-BACKGROUND: Prolonged administration of indinavir is associated with the occurrence of a variety of renal complications in adults.	indinavir	renal complications	12165618	1
-Tubular proteinuria and oxidative stress were induced by a single injection of maleate (400 mg/kg) in rats.	maleate	proteinuria	25119790	-1
-In this study we aimed to determine the rate of YMDD motif mutants in lamivudine-untreated chronic hepatitis B patients in Iran.	lamivudine	hepatitis B	17954033	-1
-The nursing staff, by reviewing the patient's health history with his family, discovered a history of polydipsia and long-standing lithium use.	lithium	polydipsia	15366550	-1
-The cause of hyperkalemia was considered to be several doses of spiranolactone, an aldosterone antagonist, in addition to the long-term intake of ramipril, an ACE inhibitor.	aldosterone	hyperkalemia	20859899	-1
-The cause of hyperkalemia was considered to be several doses of spiranolactone, an aldosterone antagonist, in addition to the long-term intake of ramipril, an ACE inhibitor.	ramipril	hyperkalemia	20859899	1
-Vasovagal syncope and severe bradycardia following intranasal dexmedetomidine for pediatric procedural sedation.	dexmedetomidine	Vasovagal syncope	24571687	1
-Vasovagal syncope and severe bradycardia following intranasal dexmedetomidine for pediatric procedural sedation.	dexmedetomidine	bradycardia	24571687	1
-This electrophysiological parameter provides information about subclinical neurotoxic potential of thalidomide but is not helpful in predicting the appearance of sensory symptoms.	thalidomide	neurotoxic	18450790	-1
-Lithium is implicated in drug-induced nephrogenic DI, and because the patient had not received lithium since being admitted to the hospital, his treatment changed to focus on nephrogenic DI.	Lithium	DI	15366550	-1
-Lithium is implicated in drug-induced nephrogenic DI, and because the patient had not received lithium since being admitted to the hospital, his treatment changed to focus on nephrogenic DI.	Lithium	nephrogenic DI	15366550	1
-Lithium is implicated in drug-induced nephrogenic DI, and because the patient had not received lithium since being admitted to the hospital, his treatment changed to focus on nephrogenic DI.	lithium	DI	15366550	-1
-Lithium is implicated in drug-induced nephrogenic DI, and because the patient had not received lithium since being admitted to the hospital, his treatment changed to focus on nephrogenic DI.	lithium	nephrogenic DI	15366550	1
-Emergency physicians should be aware of oral penicillin anaphylaxis in order to prevent its occurrence by prescribing the antibiotic judiciously and knowledgeably and to offer optimal medical therapy once this life-threatening reaction has begun.	penicillin	anaphylaxis	3083835	1
-By combining information from the patient history, the physical examination, and radiologic and laboratory studies, the critical care team demonstrated that the patient had been self-treating his lithium-induced nephrogenic DI and developed neurogenic DI secondary to brain trauma.	lithium	DI	15366550	-1
-By combining information from the patient history, the physical examination, and radiologic and laboratory studies, the critical care team demonstrated that the patient had been self-treating his lithium-induced nephrogenic DI and developed neurogenic DI secondary to brain trauma.	lithium	brain trauma	15366550	-1
-By combining information from the patient history, the physical examination, and radiologic and laboratory studies, the critical care team demonstrated that the patient had been self-treating his lithium-induced nephrogenic DI and developed neurogenic DI secondary to brain trauma.	lithium	nephrogenic DI	15366550	1
-UNASSIGNED: Our previous study has indicated that prenatal caffeine exposure (PCE) could induce intrauterine growth retardation (IUGR) of offspring.	caffeine	intrauterine growth retardation	25986755	1
-Mesangial function and glomerular sclerosis in rats with aminonucleoside nephrosis.	aminonucleoside	glomerular sclerosis	3990093	-1
-Mesangial function and glomerular sclerosis in rats with aminonucleoside nephrosis.	aminonucleoside	nephrosis	3990093	-1
-Hypotheses of heroin-related rhabdomyolysis and stroke in heroin abusers are discussed.	heroin	rhabdomyolysis	19392810	1
-Hypotheses of heroin-related rhabdomyolysis and stroke in heroin abusers are discussed.	heroin	stroke	19392810	1
-Hypotheses of heroin-related rhabdomyolysis and stroke in heroin abusers are discussed.	heroin	rhabdomyolysis	19392810	1
-PATIENTS AND METHODS: A total of 77 chronic hepatitis B patients who had not been treated with lamivudine were included in the study.	lamivudine	hepatitis B	17954033	-1
-This report describes unique contrast enhancement of the white matter on T1-weighted magnetic resonance images of two patients with disseminated necrotizing leukoencephalopathy, which developed from acute lymphoblastic leukemia treated with high-dose methotrexate.	methotrexate	acute lymphoblastic leukemia	9132810	-1
-CONCLUSION: Early recognition of optic neuropathy should be considered in patients with ethambutol therapy.	ethambutol	optic neuropathy	12948256	1
-n = 12) of patients with MDP, 12.0% (n = 3) of patients with MD, and 7.1% (n= 2) of control subjects had a panic attack after the 480-mg caffeine challenge test (chi(2)(3) = 16.22, P = .001).	caffeine	MDP	17445520	-1
-n = 12) of patients with MDP, 12.0% (n = 3) of patients with MD, and 7.1% (n= 2) of control subjects had a panic attack after the 480-mg caffeine challenge test (chi(2)(3) = 16.22, P = .001).	caffeine	panic	17445520	1
-n = 12) of patients with MDP, 12.0% (n = 3) of patients with MD, and 7.1% (n= 2) of control subjects had a panic attack after the 480-mg caffeine challenge test (chi(2)(3) = 16.22, P = .001).	caffeine	MD	17445520	-1
-A case of acute renal failure, due to occlusion of renal vessels in a patient with acute promyelocytic leukemia (APL) treated with all-trans-retinoic acid (ATRA) and tranexamic acid has been described recently.	tranexamic acid	acute renal failure	9158667	-1
-A case of acute renal failure, due to occlusion of renal vessels in a patient with acute promyelocytic leukemia (APL) treated with all-trans-retinoic acid (ATRA) and tranexamic acid has been described recently.	tranexamic acid	occlusion of renal vessels	9158667	-1
-A case of acute renal failure, due to occlusion of renal vessels in a patient with acute promyelocytic leukemia (APL) treated with all-trans-retinoic acid (ATRA) and tranexamic acid has been described recently.	tranexamic acid	acute promyelocytic leukemia	9158667	-1
-A case of acute renal failure, due to occlusion of renal vessels in a patient with acute promyelocytic leukemia (APL) treated with all-trans-retinoic acid (ATRA) and tranexamic acid has been described recently.	tranexamic acid	APL	9158667	-1
-A case of acute renal failure, due to occlusion of renal vessels in a patient with acute promyelocytic leukemia (APL) treated with all-trans-retinoic acid (ATRA) and tranexamic acid has been described recently.	all-trans-retinoic acid	acute renal failure	9158667	1
-A case of acute renal failure, due to occlusion of renal vessels in a patient with acute promyelocytic leukemia (APL) treated with all-trans-retinoic acid (ATRA) and tranexamic acid has been described recently.	all-trans-retinoic acid	occlusion of renal vessels	9158667	-1
-A case of acute renal failure, due to occlusion of renal vessels in a patient with acute promyelocytic leukemia (APL) treated with all-trans-retinoic acid (ATRA) and tranexamic acid has been described recently.	all-trans-retinoic acid	acute promyelocytic leukemia	9158667	-1
-A case of acute renal failure, due to occlusion of renal vessels in a patient with acute promyelocytic leukemia (APL) treated with all-trans-retinoic acid (ATRA) and tranexamic acid has been described recently.	all-trans-retinoic acid	APL	9158667	-1
-A case of acute renal failure, due to occlusion of renal vessels in a patient with acute promyelocytic leukemia (APL) treated with all-trans-retinoic acid (ATRA) and tranexamic acid has been described recently.	ATRA	occlusion of renal vessels	9158667	-1
-A case of acute renal failure, due to occlusion of renal vessels in a patient with acute promyelocytic leukemia (APL) treated with all-trans-retinoic acid (ATRA) and tranexamic acid has been described recently.	ATRA	acute promyelocytic leukemia	9158667	-1
-A case of acute renal failure, due to occlusion of renal vessels in a patient with acute promyelocytic leukemia (APL) treated with all-trans-retinoic acid (ATRA) and tranexamic acid has been described recently.	ATRA	APL	9158667	-1
-Incidence of solid tumours among pesticide applicators exposed to the organophosphate insecticide diazinon in the Agricultural Health Study: an updated analysis.	diazinon	tumours	25907210	-1
-Incidence of solid tumours among pesticide applicators exposed to the organophosphate insecticide diazinon in the Agricultural Health Study: an updated analysis.	organophosphate	tumours	25907210	-1
-We present magnetic resonance imaging findings of a 5-year-old girl who had a rapidly installing hemolytic anemia crisis induced by trimethoprim-sulfomethoxazole, resulting in cerebral anoxia leading to permanent damage.	trimethoprim-sulfomethoxazole	cerebral anoxia	15018178	-1
-We present magnetic resonance imaging findings of a 5-year-old girl who had a rapidly installing hemolytic anemia crisis induced by trimethoprim-sulfomethoxazole, resulting in cerebral anoxia leading to permanent damage.	trimethoprim-sulfomethoxazole	hemolytic anemia	15018178	-1
-Reduced progression of adriamycin nephropathy in spontaneously hypertensive rats treated by losartan.	adriamycin	hypertensive	18987260	-1
-Reduced progression of adriamycin nephropathy in spontaneously hypertensive rats treated by losartan.	adriamycin	nephropathy	18987260	-1
-Reduced progression of adriamycin nephropathy in spontaneously hypertensive rats treated by losartan.	losartan	hypertensive	18987260	-1
-Reduced progression of adriamycin nephropathy in spontaneously hypertensive rats treated by losartan.	losartan	nephropathy	18987260	-1
-Chronic administration of estrogen to the Fischer 344 (F344) rat induces growth of large, hemorrhagic pituitary tumors.	estrogen	hemorrhagic pituitary tumors	8755612	-1
-Animal behavior, seizures (time to and incidence), death (time to and incidence), and cortical EEG tracings were recorded. INTERVENTIONS: Administration of flumazenil to animals after they had received a combination dose of cocaine and diazepam.	diazepam	death	8135424	-1
-Animal behavior, seizures (time to and incidence), death (time to and incidence), and cortical EEG tracings were recorded. INTERVENTIONS: Administration of flumazenil to animals after they had received a combination dose of cocaine and diazepam.	cocaine	seizures	8135424	1
-Animal behavior, seizures (time to and incidence), death (time to and incidence), and cortical EEG tracings were recorded. INTERVENTIONS: Administration of flumazenil to animals after they had received a combination dose of cocaine and diazepam.	cocaine	death	8135424	-1
-Animal behavior, seizures (time to and incidence), death (time to and incidence), and cortical EEG tracings were recorded. INTERVENTIONS: Administration of flumazenil to animals after they had received a combination dose of cocaine and diazepam.	flumazenil	death	8135424	-1
-In this study, we explored the importance of pathological Ca(2+) signaling in aconitine poisoning in vitro and in vivo.	Ca(2	poisoning	24840785	-1
-Chloroacetaldehyde as a sulfhydryl reagent: the role of critical thiol groups in ifosfamide nephropathy.	ifosfamide	nephropathy	17035713	1
-Chloroacetaldehyde as a sulfhydryl reagent: the role of critical thiol groups in ifosfamide nephropathy.	Chloroacetaldehyde	nephropathy	17035713	-1
-Chloroacetaldehyde as a sulfhydryl reagent: the role of critical thiol groups in ifosfamide nephropathy.	thiol	nephropathy	17035713	-1
-These findings suggest the hypothesis that the catalepsy that is produced by neuroleptics such as haloperidol is actually mediated by intrinsic central cholinergic systems.	haloperidol	catalepsy	3925479	1
-Second, the anticonvulsant effect of MK-801 in the lithium-pilocarpine model only occurred after initial periods of seizure activity.	MK-801	seizure	2553470	-1
-Second, the anticonvulsant effect of MK-801 in the lithium-pilocarpine model only occurred after initial periods of seizure activity.	lithium	seizure	2553470	-1
-Second, the anticonvulsant effect of MK-801 in the lithium-pilocarpine model only occurred after initial periods of seizure activity.	pilocarpine	seizure	2553470	-1
-CONCLUSION: Our results did not lend strong support to the view that the genetic variation of the DRD2 gene plays a major role in the individually variable adverse effect induced by chlorpromazine, at least in Chinese patients with schizophrenia.	chlorpromazine	schizophrenia	16867246	-1
-Binasal visual field defects are not specific to vigabatrin.	vigabatrin	visual field defects	19815465	-1
-Central nervous system toxicity following the administration of levobupivacaine for lumbar plexus block: A report of two cases.	levobupivacaine	Central nervous system toxicity	12677626	-1
-The inability of amiodarone to directly activate either human or mouse PPARalpha transiently expressed in human HepG2 hepatoma cells indicates that the effects of amiodarone on the function of this receptor were indirect.	amiodarone	hepatoma	15265979	-1
-The inability of amiodarone to directly activate either human or mouse PPARalpha transiently expressed in human HepG2 hepatoma cells indicates that the effects of amiodarone on the function of this receptor were indirect.	amiodarone	hepatoma	15265979	-1
-The inability of amiodarone to directly activate either human or mouse PPARalpha transiently expressed in human HepG2 hepatoma cells indicates that the effects of amiodarone on the function of this receptor were indirect.	PPARalpha	hepatoma	15265979	-1
-The patients with PD and MDP were more sensitive to caffeine than were patients with MD and healthy volunteers.	caffeine	MDP	17445520	-1
-The patients with PD and MDP were more sensitive to caffeine than were patients with MD and healthy volunteers.	caffeine	PD	17445520	1
-The patients with PD and MDP were more sensitive to caffeine than were patients with MD and healthy volunteers.	caffeine	MD	17445520	-1
-METHOD: One hundred twelve subjects (70% male; mean age=23.3 years [SD = 5.1]) with first-episode schizophrenia (75%), schizophreniform disorder (17%), or schizoaffective disorder (8%) were randomly assigned to treatment with olanzapine (2.5-20 mg/day) or risperidone (1-6 mg/day).	risperidone	schizophreniform disorder	17151160	-1
-METHOD: One hundred twelve subjects (70% male; mean age=23.3 years [SD = 5.1]) with first-episode schizophrenia (75%), schizophreniform disorder (17%), or schizoaffective disorder (8%) were randomly assigned to treatment with olanzapine (2.5-20 mg/day) or risperidone (1-6 mg/day).	risperidone	schizoaffective disorder	17151160	-1
-METHOD: One hundred twelve subjects (70% male; mean age=23.3 years [SD = 5.1]) with first-episode schizophrenia (75%), schizophreniform disorder (17%), or schizoaffective disorder (8%) were randomly assigned to treatment with olanzapine (2.5-20 mg/day) or risperidone (1-6 mg/day).	risperidone	schizophrenia	17151160	-1
-METHOD: One hundred twelve subjects (70% male; mean age=23.3 years [SD = 5.1]) with first-episode schizophrenia (75%), schizophreniform disorder (17%), or schizoaffective disorder (8%) were randomly assigned to treatment with olanzapine (2.5-20 mg/day) or risperidone (1-6 mg/day).	olanzapine	schizophreniform disorder	17151160	-1
-METHOD: One hundred twelve subjects (70% male; mean age=23.3 years [SD = 5.1]) with first-episode schizophrenia (75%), schizophreniform disorder (17%), or schizoaffective disorder (8%) were randomly assigned to treatment with olanzapine (2.5-20 mg/day) or risperidone (1-6 mg/day).	olanzapine	schizoaffective disorder	17151160	-1
-METHOD: One hundred twelve subjects (70% male; mean age=23.3 years [SD = 5.1]) with first-episode schizophrenia (75%), schizophreniform disorder (17%), or schizoaffective disorder (8%) were randomly assigned to treatment with olanzapine (2.5-20 mg/day) or risperidone (1-6 mg/day).	olanzapine	schizophrenia	17151160	-1
-There were a significant dilatation of tubular lumens, extensive epithelial cell vacuolization, atrophy, desquamation, and necrosis in VCM-treated rats more than those of the control and the erdosteine groups.	VCM	necrosis	16112787	-1
-There were a significant dilatation of tubular lumens, extensive epithelial cell vacuolization, atrophy, desquamation, and necrosis in VCM-treated rats more than those of the control and the erdosteine groups.	VCM	atrophy	16112787	-1
-There were a significant dilatation of tubular lumens, extensive epithelial cell vacuolization, atrophy, desquamation, and necrosis in VCM-treated rats more than those of the control and the erdosteine groups.	erdosteine	necrosis	16112787	-1
-There were a significant dilatation of tubular lumens, extensive epithelial cell vacuolization, atrophy, desquamation, and necrosis in VCM-treated rats more than those of the control and the erdosteine groups.	erdosteine	atrophy	16112787	-1
-We describe 2 cases of grand mal seizures following accidental intravascular injection of levobupivacaine.	levobupivacaine	seizures	12677626	-1
-induced catalepsy and antagonized apomorphine and dexamphetamine stereotypies.	dexamphetamine	catalepsy	15614572	-1
-induced catalepsy and antagonized apomorphine and dexamphetamine stereotypies.	apomorphine	catalepsy	15614572	1
-Hence, our results suggest that aconitine significantly aggravates Ca(2+) overload and causes arrhythmia and finally promotes apoptotic development via phosphorylation of P38 mitogen-activated protein kinase.	Ca(2	arrhythmia	24840785	-1
-Immediately after the administration of levobupivacaine 0.5% with epinephrine 2.5 microgram/mL, the patients developed grand mal seizures, despite negative aspiration for blood and no clinical signs of intravenous epinephrine administration.	levobupivacaine	seizures	12677626	-1
-Immediately after the administration of levobupivacaine 0.5% with epinephrine 2.5 microgram/mL, the patients developed grand mal seizures, despite negative aspiration for blood and no clinical signs of intravenous epinephrine administration.	epinephrine	seizures	12677626	-1
-Immediately after the administration of levobupivacaine 0.5% with epinephrine 2.5 microgram/mL, the patients developed grand mal seizures, despite negative aspiration for blood and no clinical signs of intravenous epinephrine administration.	epinephrine	seizures	12677626	-1
-We report a case of methyldopa-induced hemolytic anemia in a 15-year-old boy who presented to the emergency department with near-syncope.	methyldopa	hemolytic anemia	2320485	1
-We report a case of methyldopa-induced hemolytic anemia in a 15-year-old boy who presented to the emergency department with near-syncope.	methyldopa	syncope	2320485	-1
-The peptide CCK-5-8 had weak anticonvulsant activity in comparison to the octapeptides, 3.2 mumol/kg and larger doses of the reference drug, diazepam, totally prevented picrotoxin-induced seizures and mortality.	CCK-5-8	seizures	6316193	-1
-The peptide CCK-5-8 had weak anticonvulsant activity in comparison to the octapeptides, 3.2 mumol/kg and larger doses of the reference drug, diazepam, totally prevented picrotoxin-induced seizures and mortality.	diazepam	seizures	6316193	-1
-The crude rate of VTE per 10,000 woman-years was 4.10 in current users of any OC, 3.10 in users of second-generation OCs, and 4.96 in users of third-generation preparations.	OC	VTE	8996419	-1
-The seizures were successfully treated with sodium thiopental in addition to succinylcholine in 1 patient.	sodium thiopental	seizures	12677626	-1
-The seizures were successfully treated with sodium thiopental in addition to succinylcholine in 1 patient.	succinylcholine	seizures	12677626	-1
-BACKGROUND: In dogs, a large amount of intravenous cocaine causes a profound deterioration of left ventricular (LV) systolic function and an increase in LV end-diastolic pressure.	cocaine	LV	9570197	1
-BACKGROUND: In dogs, a large amount of intravenous cocaine causes a profound deterioration of left ventricular (LV) systolic function and an increase in LV end-diastolic pressure.	cocaine	LV	9570197	1
-Therefore, the effect of bis(p-nitrophenyl) phosphate (BNPP), an acylamidase inhibitor, on APAP and PAP nephrotoxicity and metabolism was determined.	bis(p	nephrotoxicity	4082192	-1
-Therefore, the effect of bis(p-nitrophenyl) phosphate (BNPP), an acylamidase inhibitor, on APAP and PAP nephrotoxicity and metabolism was determined.	APAP	nephrotoxicity	4082192	-1
-Therefore, the effect of bis(p-nitrophenyl) phosphate (BNPP), an acylamidase inhibitor, on APAP and PAP nephrotoxicity and metabolism was determined.	phosphate	nephrotoxicity	4082192	-1
-Therefore, the effect of bis(p-nitrophenyl) phosphate (BNPP), an acylamidase inhibitor, on APAP and PAP nephrotoxicity and metabolism was determined.	-nitrophenyl	nephrotoxicity	4082192	-1
-Therefore, the effect of bis(p-nitrophenyl) phosphate (BNPP), an acylamidase inhibitor, on APAP and PAP nephrotoxicity and metabolism was determined.	PAP	nephrotoxicity	4082192	-1
-. We suggest that trazodone (5, 10 and 20 mg/kg), by blocking the 5-HT 2C receptors, releases the nigrostriatal DAergic neurons from tonic inhibition caused by 5-HT, and thereby potentiates dexamphetamine stereotypy and antagonizes haloperidol catalepsy.	trazodone	catalepsy	15614572	-1
-. We suggest that trazodone (5, 10 and 20 mg/kg), by blocking the 5-HT 2C receptors, releases the nigrostriatal DAergic neurons from tonic inhibition caused by 5-HT, and thereby potentiates dexamphetamine stereotypy and antagonizes haloperidol catalepsy.	dexamphetamine	catalepsy	15614572	-1
-. We suggest that trazodone (5, 10 and 20 mg/kg), by blocking the 5-HT 2C receptors, releases the nigrostriatal DAergic neurons from tonic inhibition caused by 5-HT, and thereby potentiates dexamphetamine stereotypy and antagonizes haloperidol catalepsy.	haloperidol	catalepsy	15614572	1
-. We suggest that trazodone (5, 10 and 20 mg/kg), by blocking the 5-HT 2C receptors, releases the nigrostriatal DAergic neurons from tonic inhibition caused by 5-HT, and thereby potentiates dexamphetamine stereotypy and antagonizes haloperidol catalepsy.	5-HT	catalepsy	15614572	-1
-. We suggest that trazodone (5, 10 and 20 mg/kg), by blocking the 5-HT 2C receptors, releases the nigrostriatal DAergic neurons from tonic inhibition caused by 5-HT, and thereby potentiates dexamphetamine stereotypy and antagonizes haloperidol catalepsy.	5-HT	catalepsy	15614572	-1
-Phenytoin induced fatal hepatic injury.	Phenytoin	hepatic injury	2818777	-1
-The present study was aimed to determine whether there is an altered regulation of tubular transporters in gentamicin-induced nephropathy.	gentamicin	nephropathy	19967075	1
-CONCLUSIONS: Although levobupivacaine may have a safer cardiac toxicity profile than racemic bupivacaine, if adequate amounts of levobupivacaine reach the circulation, it will result in convulsions.	levobupivacaine	cardiac toxicity	12677626	-1
-CONCLUSIONS: Although levobupivacaine may have a safer cardiac toxicity profile than racemic bupivacaine, if adequate amounts of levobupivacaine reach the circulation, it will result in convulsions.	levobupivacaine	convulsions	12677626	-1
-CONCLUSIONS: Although levobupivacaine may have a safer cardiac toxicity profile than racemic bupivacaine, if adequate amounts of levobupivacaine reach the circulation, it will result in convulsions.	levobupivacaine	cardiac toxicity	12677626	-1
-CONCLUSIONS: Although levobupivacaine may have a safer cardiac toxicity profile than racemic bupivacaine, if adequate amounts of levobupivacaine reach the circulation, it will result in convulsions.	levobupivacaine	convulsions	12677626	-1
-CONCLUSIONS: Although levobupivacaine may have a safer cardiac toxicity profile than racemic bupivacaine, if adequate amounts of levobupivacaine reach the circulation, it will result in convulsions.	bupivacaine	cardiac toxicity	12677626	-1
-CONCLUSIONS: Although levobupivacaine may have a safer cardiac toxicity profile than racemic bupivacaine, if adequate amounts of levobupivacaine reach the circulation, it will result in convulsions.	bupivacaine	convulsions	12677626	-1
-We evaluated the association of alcohol consumption and depression, and their effects on HIV disease progression among women with HIV.	alcohol	HIV disease	20024739	-1
-We evaluated the association of alcohol consumption and depression, and their effects on HIV disease progression among women with HIV.	alcohol	HIV	20024739	-1
-We evaluated the association of alcohol consumption and depression, and their effects on HIV disease progression among women with HIV.	alcohol	depression	20024739	1
-Levodopa-induced dyskinesias are improved by fluoxetine.	fluoxetine	dyskinesias	7477981	1
-Levodopa-induced dyskinesias are improved by fluoxetine.	Levodopa	dyskinesias	7477981	-1
-Fully developed cyclophosphamide-induced cystitis is characterized by nearly complete detachment of the urothelium, severe submucosal edema owing to damage to the microvascular bed and focal muscle necroses.	cyclophosphamide	submucosal edema	3109094	-1
-Fully developed cyclophosphamide-induced cystitis is characterized by nearly complete detachment of the urothelium, severe submucosal edema owing to damage to the microvascular bed and focal muscle necroses.	cyclophosphamide	cystitis	3109094	-1
-When tested in a multivariate regression analysis, tranexamic acid was a strong independent predictor of seizures (OR 14.3, 95% CI 5.5-36.7; p < 0.001).	tranexamic acid	seizures	24588023	1
-PURPOSE: To assess the antiemetic effects and safety profile of four different doses of granisetron (Kytril; SmithKline Beecham Pharmaceuticals, Philadelphia, PA) when administered as a single intravenous (IV) dose for prophylaxis of cisplatin-induced nausea and vomiting.	granisetron	nausea	7931490	-1
-PURPOSE: To assess the antiemetic effects and safety profile of four different doses of granisetron (Kytril; SmithKline Beecham Pharmaceuticals, Philadelphia, PA) when administered as a single intravenous (IV) dose for prophylaxis of cisplatin-induced nausea and vomiting.	granisetron	vomiting	7931490	-1
-PURPOSE: To assess the antiemetic effects and safety profile of four different doses of granisetron (Kytril; SmithKline Beecham Pharmaceuticals, Philadelphia, PA) when administered as a single intravenous (IV) dose for prophylaxis of cisplatin-induced nausea and vomiting.	Kytril	nausea	7931490	-1
-PURPOSE: To assess the antiemetic effects and safety profile of four different doses of granisetron (Kytril; SmithKline Beecham Pharmaceuticals, Philadelphia, PA) when administered as a single intravenous (IV) dose for prophylaxis of cisplatin-induced nausea and vomiting.	Kytril	vomiting	7931490	-1
-PURPOSE: To assess the antiemetic effects and safety profile of four different doses of granisetron (Kytril; SmithKline Beecham Pharmaceuticals, Philadelphia, PA) when administered as a single intravenous (IV) dose for prophylaxis of cisplatin-induced nausea and vomiting.	cisplatin	nausea	7931490	1
-Gentamicin-induced nephropathy may at least in part be causally related with a decreased expression of Na(+)/K(+)-ATPase, NHE3, NBC1, AQP1 and OAT.	Gentamicin	OAT	19967075	-1
-Gentamicin-induced nephropathy may at least in part be causally related with a decreased expression of Na(+)/K(+)-ATPase, NHE3, NBC1, AQP1 and OAT.	Gentamicin	nephropathy	19967075	1
-Gentamicin-induced nephropathy may at least in part be causally related with a decreased expression of Na(+)/K(+)-ATPase, NHE3, NBC1, AQP1 and OAT.	Na(+)/K(+)-ATPase	OAT	19967075	-1
-Gentamicin-induced nephropathy may at least in part be causally related with a decreased expression of Na(+)/K(+)-ATPase, NHE3, NBC1, AQP1 and OAT.	Na(+)/K(+)-ATPase	nephropathy	19967075	-1
-However, while DES-induced pituitary growth exhibited quantitative, additive inheritance, the hemorrhagic phenotype exhibited recessive, epistatic inheritance.	DES	hemorrhagic	8755612	-1
-To report a sinus bradycardia induced by metoprolol and terbinafine drug-drug interaction and its management.	terbinafine	sinus bradycardia	24894748	-1
-To report a sinus bradycardia induced by metoprolol and terbinafine drug-drug interaction and its management.	metoprolol	sinus bradycardia	24894748	-1
-Piperacillin-induced encephalopathy should be considered in any uremic patients with unexplained neurological manifestations.	Piperacillin	encephalopathy	17496739	-1
-Piperacillin-induced encephalopathy should be considered in any uremic patients with unexplained neurological manifestations.	Piperacillin	uremic	17496739	-1
-Soon after the introduction of ACE inhibitors, acute bouts of angio-oedema were reported in association with the use of these drugs.	ACE inhibitors	angio-oedema	7671401	-1
-Pilocarpine, given intraperitoneally to rats, reproduces the neuropathological sequelae of temporal lobe epilepsy and provides a relevant animal model for studying mechanisms of buildup of convulsive activity and pathways operative in the generalization and propagation of seizures within the forebrain.	Pilocarpine	convulsive	3708328	1
-Pilocarpine, given intraperitoneally to rats, reproduces the neuropathological sequelae of temporal lobe epilepsy and provides a relevant animal model for studying mechanisms of buildup of convulsive activity and pathways operative in the generalization and propagation of seizures within the forebrain.	Pilocarpine	temporal lobe epilepsy	3708328	-1
-LV hypertrophy induced by Iso treatment was significantly higher in TGR than in SD rats (in g LV wt/100 g body wt, 0.28 +/-	Iso	LV	16731636	-1
-LV hypertrophy induced by Iso treatment was significantly higher in TGR than in SD rats (in g LV wt/100 g body wt, 0.28 +/-	Iso	LV hypertrophy	16731636	-1
-7e exhibits a high reversal of catalepsy induced by haloperidol indicating its atypical antipsychotic nature.	haloperidol	catalepsy	10510854	1
-"Real-world" data on the efficacy and safety of lenalidomide and dexamethasone in patients with relapsed/refractory multiple myeloma who were treated according to the standard clinical practice: a study of the Greek Myeloma Study Group.	dexamethasone	myeloma	23892921	-1
-"Real-world" data on the efficacy and safety of lenalidomide and dexamethasone in patients with relapsed/refractory multiple myeloma who were treated according to the standard clinical practice: a study of the Greek Myeloma Study Group.	dexamethasone	Myeloma	23892921	-1
-"Real-world" data on the efficacy and safety of lenalidomide and dexamethasone in patients with relapsed/refractory multiple myeloma who were treated according to the standard clinical practice: a study of the Greek Myeloma Study Group.	lenalidomide	myeloma	23892921	-1
-"Real-world" data on the efficacy and safety of lenalidomide and dexamethasone in patients with relapsed/refractory multiple myeloma who were treated according to the standard clinical practice: a study of the Greek Myeloma Study Group.	lenalidomide	Myeloma	23892921	-1
-Dyskinesia was present in 44% (n = 42) with median levodopa therapy of 3 years.	levodopa	Dyskinesia	23952588	1
-The authors present a case of early (within 4 days) development of torsade de pointes (TdP) associated with oral amiodarone therapy.	amiodarone	TdP	12678199	1
-mmol/L, serum osmolality was 263 mosmol/kg, urine osmolality 410 mosmol/kg and urine sodium 63 mmol/L, consistent with a diagnosis of SIADH.	sodium	SIADH	24234943	-1
-Use of propranolol in the treatment of idiopathic orthostatic hypotension.	propranolol	idiopathic orthostatic hypotension	611664	-1
-The aim of this study was to characterize the oropharyngeal dynamics in PD patients with and without levodopa-induced dyskinesia.	levodopa	PD	15625689	-1
-Consistent with other reports this case of TdP occurred in the context of multiple exacerbating factors including hypokalemia and digoxin excess.	digoxin	TdP	12678199	-1
-Consistent with other reports this case of TdP occurred in the context of multiple exacerbating factors including hypokalemia and digoxin excess.	digoxin	hypokalemia	12678199	-1
-Treatment with L-DOPA+benserazide (12 weeks) resulted in less severe dyskinesias in CB1 KO than in WT mice.	L-DOPA+benserazide	dyskinesias	19419794	-1
-Treatment with L-DOPA+benserazide (12 weeks) resulted in less severe dyskinesias in CB1 KO than in WT mice.	KO	dyskinesias	19419794	-1
-The possible relationship between mesangial dysfunction and development of glomerular sclerosis was studied in the puromycin aminonucleoside (PAN) model.	puromycin aminonucleoside	mesangial dysfunction	3990093	-1
-The possible relationship between mesangial dysfunction and development of glomerular sclerosis was studied in the puromycin aminonucleoside (PAN) model.	puromycin aminonucleoside	glomerular sclerosis	3990093	-1
-The possible relationship between mesangial dysfunction and development of glomerular sclerosis was studied in the puromycin aminonucleoside (PAN) model.	PAN	mesangial dysfunction	3990093	-1
-The possible relationship between mesangial dysfunction and development of glomerular sclerosis was studied in the puromycin aminonucleoside (PAN) model.	PAN	glomerular sclerosis	3990093	-1
-Phase II study of carboplatin and liposomal doxorubicin in patients with recurrent squamous cell carcinoma of the cervix.	doxorubicin	squamous cell carcinoma	11745287	-1
-Phase II study of carboplatin and liposomal doxorubicin in patients with recurrent squamous cell carcinoma of the cervix.	carboplatin	squamous cell carcinoma	11745287	-1
-In the absence of amiodarone therapy, a second bladder irrigation did not induce TdP despite hypokalemia and hypomagnesemia.	amiodarone	hypomagnesemia	12678199	-1
-In the absence of amiodarone therapy, a second bladder irrigation did not induce TdP despite hypokalemia and hypomagnesemia.	amiodarone	hypokalemia	12678199	-1
-These results suggest that activation of NMDA receptors plays an important role in status epilepticus and brain damage in the lithium-pilocarpine model.	lithium	brain damage	2553470	-1
-These results suggest that activation of NMDA receptors plays an important role in status epilepticus and brain damage in the lithium-pilocarpine model.	pilocarpine	brain damage	2553470	-1
-Efficacy and proarrhythmia with the use of d,l-sotalol for sustained ventricular tachyarrhythmias.	l-sotalol	ventricular tachyarrhythmias	9125676	-1
-A case of postoperative anxiety due to low dose droperidol used with patient-controlled analgesia.	droperidol	postoperative anxiety	15321332	-1
-A case of postoperative anxiety due to low dose droperidol used with patient-controlled analgesia.	droperidol	analgesia	15321332	-1
-Our findings suggest that the changes leading to an alteration of myocardial dynamic imaging with I-131 HA are not the initiating factor in doxorubicin cardiotoxicity.	doxorubicin	cardiotoxicity	6631522	1
-Chloroacetaldehyde (CAA) is a metabolite of the alkylating agent ifosfamide (IFO) and putatively responsible for renal damage following anti-tumor therapy with IFO.	ifosfamide	tumor	17035713	-1
-Chloroacetaldehyde (CAA) is a metabolite of the alkylating agent ifosfamide (IFO) and putatively responsible for renal damage following anti-tumor therapy with IFO.	IFO	tumor	17035713	-1
-Chloroacetaldehyde (CAA) is a metabolite of the alkylating agent ifosfamide (IFO) and putatively responsible for renal damage following anti-tumor therapy with IFO.	IFO	tumor	17035713	-1
-Chloroacetaldehyde (CAA) is a metabolite of the alkylating agent ifosfamide (IFO) and putatively responsible for renal damage following anti-tumor therapy with IFO.	Chloroacetaldehyde	tumor	17035713	-1
-Chloroacetaldehyde (CAA) is a metabolite of the alkylating agent ifosfamide (IFO) and putatively responsible for renal damage following anti-tumor therapy with IFO.	Chloroacetaldehyde	renal damage	17035713	-1
-Chloroacetaldehyde (CAA) is a metabolite of the alkylating agent ifosfamide (IFO) and putatively responsible for renal damage following anti-tumor therapy with IFO.	CAA	tumor	17035713	-1
-Chloroacetaldehyde (CAA) is a metabolite of the alkylating agent ifosfamide (IFO) and putatively responsible for renal damage following anti-tumor therapy with IFO.	CAA	renal damage	17035713	-1
-It is also suggested that the blockade of K(+)-channels sensitive to these blockers is not sufficient to prevent morphine-induced hypoactivity whereas morphine-induced hyperactivity seems to be connected to both quinine- and 4-aminopyridine-sensitive K(+)-channels.	4-aminopyridine	hyperactivity	10390729	-1
-It is also suggested that the blockade of K(+)-channels sensitive to these blockers is not sufficient to prevent morphine-induced hypoactivity whereas morphine-induced hyperactivity seems to be connected to both quinine- and 4-aminopyridine-sensitive K(+)-channels.	4-aminopyridine	hypoactivity	10390729	-1
-It is also suggested that the blockade of K(+)-channels sensitive to these blockers is not sufficient to prevent morphine-induced hypoactivity whereas morphine-induced hyperactivity seems to be connected to both quinine- and 4-aminopyridine-sensitive K(+)-channels.	morphine	hypoactivity	10390729	-1
-It is also suggested that the blockade of K(+)-channels sensitive to these blockers is not sufficient to prevent morphine-induced hypoactivity whereas morphine-induced hyperactivity seems to be connected to both quinine- and 4-aminopyridine-sensitive K(+)-channels.	morphine	hyperactivity	10390729	1
-It is also suggested that the blockade of K(+)-channels sensitive to these blockers is not sufficient to prevent morphine-induced hypoactivity whereas morphine-induced hyperactivity seems to be connected to both quinine- and 4-aminopyridine-sensitive K(+)-channels.	morphine	hypoactivity	10390729	-1
-It is also suggested that the blockade of K(+)-channels sensitive to these blockers is not sufficient to prevent morphine-induced hypoactivity whereas morphine-induced hyperactivity seems to be connected to both quinine- and 4-aminopyridine-sensitive K(+)-channels.	K(+)-channels	hyperactivity	10390729	-1
-It is also suggested that the blockade of K(+)-channels sensitive to these blockers is not sufficient to prevent morphine-induced hypoactivity whereas morphine-induced hyperactivity seems to be connected to both quinine- and 4-aminopyridine-sensitive K(+)-channels.	K(+)-channels	hypoactivity	10390729	-1
-It is also suggested that the blockade of K(+)-channels sensitive to these blockers is not sufficient to prevent morphine-induced hypoactivity whereas morphine-induced hyperactivity seems to be connected to both quinine- and 4-aminopyridine-sensitive K(+)-channels.	K(+)-channels	hyperactivity	10390729	-1
-It is also suggested that the blockade of K(+)-channels sensitive to these blockers is not sufficient to prevent morphine-induced hypoactivity whereas morphine-induced hyperactivity seems to be connected to both quinine- and 4-aminopyridine-sensitive K(+)-channels.	K(+)-channels	hypoactivity	10390729	-1
-It is also suggested that the blockade of K(+)-channels sensitive to these blockers is not sufficient to prevent morphine-induced hypoactivity whereas morphine-induced hyperactivity seems to be connected to both quinine- and 4-aminopyridine-sensitive K(+)-channels.	quinine-	hyperactivity	10390729	-1
-It is also suggested that the blockade of K(+)-channels sensitive to these blockers is not sufficient to prevent morphine-induced hypoactivity whereas morphine-induced hyperactivity seems to be connected to both quinine- and 4-aminopyridine-sensitive K(+)-channels.	quinine-	hypoactivity	10390729	-1
-Glucose metabolism in patients with schizophrenia treated with atypical antipsychotic agents: a frequently sampled intravenous glucose tolerance test and minimal model analysis.	glucose	schizophrenia	15630069	-1
-This study investigated the visual defects associated with the antiepileptic drug vigabatrin (VGB).	vigabatrin	visual defects	19815465	1
-This study investigated the visual defects associated with the antiepileptic drug vigabatrin (VGB).	VGB	visual defects	19815465	1
-The mean H concentration during hypotension in the inspiratory gas was 0.7 +/-	H	hypotension	2718706	1
-In this study, status epilepticus was induced by systemic injection of pilocarpine in rats.	pilocarpine	status epilepticus	1756784	1
-Apparent risk factors for the development of mania or hypomania during fluoxetine pharmacotherapy in this population were the combination of attention-deficit hyperactivity disorder and affective instability; major depression with psychotic features; a family history of affective disorder, especially bipolar disorder; and a diagnosis of bipolar disorder.	fluoxetine	bipolar disorder	1564030	1
-Apparent risk factors for the development of mania or hypomania during fluoxetine pharmacotherapy in this population were the combination of attention-deficit hyperactivity disorder and affective instability; major depression with psychotic features; a family history of affective disorder, especially bipolar disorder; and a diagnosis of bipolar disorder.	fluoxetine	bipolar disorder	1564030	1
-Apparent risk factors for the development of mania or hypomania during fluoxetine pharmacotherapy in this population were the combination of attention-deficit hyperactivity disorder and affective instability; major depression with psychotic features; a family history of affective disorder, especially bipolar disorder; and a diagnosis of bipolar disorder.	fluoxetine	depression	1564030	-1
-Apparent risk factors for the development of mania or hypomania during fluoxetine pharmacotherapy in this population were the combination of attention-deficit hyperactivity disorder and affective instability; major depression with psychotic features; a family history of affective disorder, especially bipolar disorder; and a diagnosis of bipolar disorder.	fluoxetine	attention-deficit hyperactivity disorder	1564030	-1
-Apparent risk factors for the development of mania or hypomania during fluoxetine pharmacotherapy in this population were the combination of attention-deficit hyperactivity disorder and affective instability; major depression with psychotic features; a family history of affective disorder, especially bipolar disorder; and a diagnosis of bipolar disorder.	fluoxetine	affective disorder	1564030	-1
-Apparent risk factors for the development of mania or hypomania during fluoxetine pharmacotherapy in this population were the combination of attention-deficit hyperactivity disorder and affective instability; major depression with psychotic features; a family history of affective disorder, especially bipolar disorder; and a diagnosis of bipolar disorder.	fluoxetine	psychotic	1564030	-1
-Hemodynamic and antiadrenergic effects of dronedarone and amiodarone in animals with a healed myocardial infarction.	amiodarone	myocardial infarction	10975596	-1
-Hemodynamic and antiadrenergic effects of dronedarone and amiodarone in animals with a healed myocardial infarction.	dronedarone	myocardial infarction	10975596	-1
-Bupivacaine antagonizes epinephrine dysrhythmogenicity in conscious dogs susceptible to VT and in anesthetized dogs with spontaneous postinfarct dysrhythmias.	epinephrine	dysrhythmias	8659767	-1
-Bupivacaine antagonizes epinephrine dysrhythmogenicity in conscious dogs susceptible to VT and in anesthetized dogs with spontaneous postinfarct dysrhythmias.	epinephrine	VT	8659767	1
-Bupivacaine antagonizes epinephrine dysrhythmogenicity in conscious dogs susceptible to VT and in anesthetized dogs with spontaneous postinfarct dysrhythmias.	Bupivacaine	dysrhythmias	8659767	-1
-Bupivacaine antagonizes epinephrine dysrhythmogenicity in conscious dogs susceptible to VT and in anesthetized dogs with spontaneous postinfarct dysrhythmias.	Bupivacaine	VT	8659767	-1
-Pharmacodynamics of the hypotensive effect of levodopa in parkinsonian patients.	levodopa	parkinsonian	1423336	-1
-Pharmacodynamics of the hypotensive effect of levodopa in parkinsonian patients.	levodopa	hypotensive	1423336	1
-An adverse drug interaction with piroxicam, which she took occasionally, may have exacerbated the coagulopathy.	piroxicam	coagulopathy	8308951	-1
-Toxicities were compared with a cohort of patients in a phase I trial of paclitaxel alone at identical dose levels.	paclitaxel	Toxicities	7644931	-1
-Azotemia was not related to duration of therapy or serum tobramycin concentration.	tobramycin	Azotemia	256433	1
-Peri-operative atrioventricular block as a result of chemotherapy with epirubicin and paclitaxel.	epirubicin	atrioventricular block	17223814	1
-Consequently, dronedarone might be particularly suitable for the treatment and prevention of various clinical arrhythmias, without compromising the left ventricular function.	dronedarone	arrhythmias	10975596	-1
-This study was done to assess the influence of a high intracoronary cocaine concentration on LV systolic and diastolic function in humans.	cocaine	LV	9570197	1
-Patients with dyskinesia had lower onset age ( p < 0.001), longer duration of levodopa therapy ( p < 0.001), longer disease duration ( p < 0.001), higher total daily levodopa dose ( p	levodopa	dyskinesia	23952588	1
-The present case highlights the possibility that differential diagnosis between an amiodarone-related pulmonary lesion and a neoplasm can be very difficult radiologically, and suggests that membranous glomerulonephritis might be another possible complication of amiodarone treatment.	amiodarone	membranous glomerulonephritis	18801087	1
-The present case highlights the possibility that differential diagnosis between an amiodarone-related pulmonary lesion and a neoplasm can be very difficult radiologically, and suggests that membranous glomerulonephritis might be another possible complication of amiodarone treatment.	amiodarone	pulmonary lesion	18801087	-1
-The present case highlights the possibility that differential diagnosis between an amiodarone-related pulmonary lesion and a neoplasm can be very difficult radiologically, and suggests that membranous glomerulonephritis might be another possible complication of amiodarone treatment.	amiodarone	pulmonary lesion	18801087	-1
-Nociceptin/orphanin FQ and nocistatin on learning and memory impairment induced by scopolamine in mice.	nocistatin	memory impairment	10401555	-1
-Nociceptin/orphanin FQ and nocistatin on learning and memory impairment induced by scopolamine in mice.	orphanin FQ	memory impairment	10401555	-1
-Nociceptin/orphanin FQ and nocistatin on learning and memory impairment induced by scopolamine in mice.	scopolamine	memory impairment	10401555	1
-After dipyridamole, ischemic ST-segment depression (0.05 mV or more) was observed in 84% of the non-MI group, 29% of the ANT-MI group, 63% of the INF-MI group and 61% of the total population.	dipyridamole	ischemic ST-segment depression	3746148	-1
-After dipyridamole, ischemic ST-segment depression (0.05 mV or more) was observed in 84% of the non-MI group, 29% of the ANT-MI group, 63% of the INF-MI group and 61% of the total population.	dipyridamole	MI	3746148	-1
-After dipyridamole, ischemic ST-segment depression (0.05 mV or more) was observed in 84% of the non-MI group, 29% of the ANT-MI group, 63% of the INF-MI group and 61% of the total population.	dipyridamole	MI	3746148	-1
-After dipyridamole, ischemic ST-segment depression (0.05 mV or more) was observed in 84% of the non-MI group, 29% of the ANT-MI group, 63% of the INF-MI group and 61% of the total population.	dipyridamole	MI	3746148	-1
-CONCLUSIONS: Precurarization with 0.04 mg/kg rocuronium was the optimal dose considering the reduction in the incidence and severity of fasciculation and myalgia with acceptable onset time, and the safe and effective precurarization.	rocuronium	fasciculation	25006369	-1
-CONCLUSIONS: Precurarization with 0.04 mg/kg rocuronium was the optimal dose considering the reduction in the incidence and severity of fasciculation and myalgia with acceptable onset time, and the safe and effective precurarization.	rocuronium	myalgia	25006369	-1
-Finally, the IKr blockers, Terfenadine and Citalopram, which are reported to cause Torsade de Pointes (TdP) in clinical practice, produced early afterdepolarization (EAD).	Citalopram	Torsade de Pointes	24742750	1
-Finally, the IKr blockers, Terfenadine and Citalopram, which are reported to cause Torsade de Pointes (TdP) in clinical practice, produced early afterdepolarization (EAD).	Citalopram	TdP	24742750	1
-Long-term oestrogen-only HT also significantly increased the risk of stroke and gallbladder disease.	oestrogen	gallbladder disease	16034922	1
-We evaluated the severity of motor disability and dyskinesias in seven levodopa-responsive patients with Parkinson's disease after an acute challenge with the mixed dopamine agonist, apomorphine, before and after the administration of fluoxetine (20 mg twice per day) for 11 +/-	dopamine	Parkinson's disease	7477981	-1
-We evaluated the severity of motor disability and dyskinesias in seven levodopa-responsive patients with Parkinson's disease after an acute challenge with the mixed dopamine agonist, apomorphine, before and after the administration of fluoxetine (20 mg twice per day) for 11 +/-	dopamine	dyskinesias	7477981	-1
-We evaluated the severity of motor disability and dyskinesias in seven levodopa-responsive patients with Parkinson's disease after an acute challenge with the mixed dopamine agonist, apomorphine, before and after the administration of fluoxetine (20 mg twice per day) for 11 +/-	apomorphine	Parkinson's disease	7477981	-1
-We evaluated the severity of motor disability and dyskinesias in seven levodopa-responsive patients with Parkinson's disease after an acute challenge with the mixed dopamine agonist, apomorphine, before and after the administration of fluoxetine (20 mg twice per day) for 11 +/-	apomorphine	dyskinesias	7477981	1
-We evaluated the severity of motor disability and dyskinesias in seven levodopa-responsive patients with Parkinson's disease after an acute challenge with the mixed dopamine agonist, apomorphine, before and after the administration of fluoxetine (20 mg twice per day) for 11 +/-	fluoxetine	Parkinson's disease	7477981	-1
-We evaluated the severity of motor disability and dyskinesias in seven levodopa-responsive patients with Parkinson's disease after an acute challenge with the mixed dopamine agonist, apomorphine, before and after the administration of fluoxetine (20 mg twice per day) for 11 +/-	levodopa	Parkinson's disease	7477981	-1
-We evaluated the severity of motor disability and dyskinesias in seven levodopa-responsive patients with Parkinson's disease after an acute challenge with the mixed dopamine agonist, apomorphine, before and after the administration of fluoxetine (20 mg twice per day) for 11 +/-	levodopa	dyskinesias	7477981	-1
-A 41-year-old woman with a strong history of postoperative nausea and vomiting presented for abdominal hysterectomy 3 months after a previous anaesthetic where ondansetron prophylaxis had been used.	ondansetron	postoperative nausea and vomiting	9323412	-1
-The patients, a 43-year-old man, presented all the signs and symptoms of APL and was included in a treatment protocol with ATRA.	ATRA	APL	9158667	-1
-5-Fluorouracil plus folinic acid and paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) are effective salvage therapies for metastatic breast cancer patients.	paclitaxel	breast cancer	9071336	-1
-5-Fluorouracil plus folinic acid and paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) are effective salvage therapies for metastatic breast cancer patients.	Taxol	breast cancer	9071336	-1
-5-Fluorouracil plus folinic acid and paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) are effective salvage therapies for metastatic breast cancer patients.	5-Fluorouracil	breast cancer	9071336	-1
-5-Fluorouracil plus folinic acid and paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) are effective salvage therapies for metastatic breast cancer patients.	folinic acid	breast cancer	9071336	-1
-Within the 48 h following the gradual introduction of quetiapine (up to 600 mg/day), the patient presented severe agitation without an environmental explanation, contrasting with the absence of a history of aggressiveness or personality disorder.	quetiapine	aggressiveness or personality disorder	24582773	-1
-Within the 48 h following the gradual introduction of quetiapine (up to 600 mg/day), the patient presented severe agitation without an environmental explanation, contrasting with the absence of a history of aggressiveness or personality disorder.	quetiapine	agitation	24582773	1
-Antitumor effect, cardiotoxicity, and nephrotoxicity of doxorubicin in the IgM solid immunocytoma-bearing LOU/M/WSL rat.	doxorubicin	cardiotoxicity	6585590	-1
-Antitumor effect, cardiotoxicity, and nephrotoxicity of doxorubicin in the IgM solid immunocytoma-bearing LOU/M/WSL rat.	doxorubicin	nephrotoxicity	6585590	-1
-The enhancement of aminonucleoside nephrosis by the co-administration of protamine.	aminonucleoside	nephrosis	3323599	-1
-The enhancement of aminonucleoside nephrosis by the co-administration of protamine.	protamine	nephrosis	3323599	-1
-Thrombotic events, however, could be avoided by using low-dose heparin.	heparin	Thrombotic	9158667	-1
-A 63 year-old Caucasian man on metoprolol 200 mg/day for stable coronary artery disease was prescribed a 90-day course of oral terbinafine 250 mg/day for onychomycosis.	terbinafine	coronary artery disease	24894748	-1
-A 63 year-old Caucasian man on metoprolol 200 mg/day for stable coronary artery disease was prescribed a 90-day course of oral terbinafine 250 mg/day for onychomycosis.	terbinafine	onychomycosis	24894748	-1
-A 63 year-old Caucasian man on metoprolol 200 mg/day for stable coronary artery disease was prescribed a 90-day course of oral terbinafine 250 mg/day for onychomycosis.	metoprolol	coronary artery disease	24894748	-1
-A 63 year-old Caucasian man on metoprolol 200 mg/day for stable coronary artery disease was prescribed a 90-day course of oral terbinafine 250 mg/day for onychomycosis.	metoprolol	onychomycosis	24894748	-1
-Microinjections of gamma-vinyl-GABA, 5 micrograms, into the dorsal striatum, bilaterally, failed to prevent the development of convulsions produced by pilocarpine, 380 mg/kg.	gamma-vinyl	convulsions	3708328	-1
-Microinjections of gamma-vinyl-GABA, 5 micrograms, into the dorsal striatum, bilaterally, failed to prevent the development of convulsions produced by pilocarpine, 380 mg/kg.	GABA	convulsions	3708328	-1
-Microinjections of gamma-vinyl-GABA, 5 micrograms, into the dorsal striatum, bilaterally, failed to prevent the development of convulsions produced by pilocarpine, 380 mg/kg.	pilocarpine	convulsions	3708328	1
-Neither propranolol nor B 24/76 could stop the changes in the characteristic myosin isoenzyme pattern of the hypertrophied rat heart.	propranolol	hypertrophied	2974281	-1
-Phase 2 trial of liposomal doxorubicin (40 mg/m(2)) in platinum/paclitaxel-refractory ovarian and fallopian tube cancers and primary carcinoma of the peritoneum.	doxorubicin	fallopian tube cancers	10985896	-1
-Phase 2 trial of liposomal doxorubicin (40 mg/m(2)) in platinum/paclitaxel-refractory ovarian and fallopian tube cancers and primary carcinoma of the peritoneum.	doxorubicin	carcinoma	10985896	-1
-Phase 2 trial of liposomal doxorubicin (40 mg/m(2)) in platinum/paclitaxel-refractory ovarian and fallopian tube cancers and primary carcinoma of the peritoneum.	doxorubicin	ovarian	10985896	-1
-Phase 2 trial of liposomal doxorubicin (40 mg/m(2)) in platinum/paclitaxel-refractory ovarian and fallopian tube cancers and primary carcinoma of the peritoneum.	paclitaxel	fallopian tube cancers	10985896	-1
-Phase 2 trial of liposomal doxorubicin (40 mg/m(2)) in platinum/paclitaxel-refractory ovarian and fallopian tube cancers and primary carcinoma of the peritoneum.	paclitaxel	carcinoma	10985896	-1
-Phase 2 trial of liposomal doxorubicin (40 mg/m(2)) in platinum/paclitaxel-refractory ovarian and fallopian tube cancers and primary carcinoma of the peritoneum.	paclitaxel	ovarian	10985896	-1
-Phase 2 trial of liposomal doxorubicin (40 mg/m(2)) in platinum/paclitaxel-refractory ovarian and fallopian tube cancers and primary carcinoma of the peritoneum.	platinum	fallopian tube cancers	10985896	-1
-Phase 2 trial of liposomal doxorubicin (40 mg/m(2)) in platinum/paclitaxel-refractory ovarian and fallopian tube cancers and primary carcinoma of the peritoneum.	platinum	carcinoma	10985896	-1
-Phase 2 trial of liposomal doxorubicin (40 mg/m(2)) in platinum/paclitaxel-refractory ovarian and fallopian tube cancers and primary carcinoma of the peritoneum.	platinum	ovarian	10985896	-1
-Clinicians should be alert to the possibility of hyperkalemia, especially in elderly patients using ACE/ARB in combination with potassium sparing agents and who have mild renal disturbance.	potassium	hyperkalemia	20859899	-1
-Clinicians should be alert to the possibility of hyperkalemia, especially in elderly patients using ACE/ARB in combination with potassium sparing agents and who have mild renal disturbance.	potassium	renal disturbance	20859899	-1
-DESIGN: A cross-sectional design in stable, treated patients with schizophrenia evaluated using a frequently sampled intravenous glucose tolerance test and the Bergman minimal model analysis.	glucose	schizophrenia	15630069	-1
-BACKGROUND: Several studies have demonstrated liposomal doxorubicin (Doxil) to be an active antineoplastic agent in platinum-resistant ovarian cancer, with dose limiting toxicity of the standard dosing regimen (50 mg/m(2) q 4 weeks) being severe erythrodysesthesia ("hand-foot syndrome") and stomatitis.	doxorubicin	ovarian cancer	10985896	-1
-BACKGROUND: Several studies have demonstrated liposomal doxorubicin (Doxil) to be an active antineoplastic agent in platinum-resistant ovarian cancer, with dose limiting toxicity of the standard dosing regimen (50 mg/m(2) q 4 weeks) being severe erythrodysesthesia ("hand-foot syndrome") and stomatitis.	doxorubicin	toxicity	10985896	-1
-BACKGROUND: Several studies have demonstrated liposomal doxorubicin (Doxil) to be an active antineoplastic agent in platinum-resistant ovarian cancer, with dose limiting toxicity of the standard dosing regimen (50 mg/m(2) q 4 weeks) being severe erythrodysesthesia ("hand-foot syndrome") and stomatitis.	Doxil	ovarian cancer	10985896	-1
-BACKGROUND: Several studies have demonstrated liposomal doxorubicin (Doxil) to be an active antineoplastic agent in platinum-resistant ovarian cancer, with dose limiting toxicity of the standard dosing regimen (50 mg/m(2) q 4 weeks) being severe erythrodysesthesia ("hand-foot syndrome") and stomatitis.	Doxil	hand-foot syndrome	10985896	-1
-BACKGROUND: Several studies have demonstrated liposomal doxorubicin (Doxil) to be an active antineoplastic agent in platinum-resistant ovarian cancer, with dose limiting toxicity of the standard dosing regimen (50 mg/m(2) q 4 weeks) being severe erythrodysesthesia ("hand-foot syndrome") and stomatitis.	Doxil	toxicity	10985896	-1
-BACKGROUND: Several studies have demonstrated liposomal doxorubicin (Doxil) to be an active antineoplastic agent in platinum-resistant ovarian cancer, with dose limiting toxicity of the standard dosing regimen (50 mg/m(2) q 4 weeks) being severe erythrodysesthesia ("hand-foot syndrome") and stomatitis.	Doxil	stomatitis	10985896	-1
-BACKGROUND: Several studies have demonstrated liposomal doxorubicin (Doxil) to be an active antineoplastic agent in platinum-resistant ovarian cancer, with dose limiting toxicity of the standard dosing regimen (50 mg/m(2) q 4 weeks) being severe erythrodysesthesia ("hand-foot syndrome") and stomatitis.	platinum	ovarian cancer	10985896	-1
-BACKGROUND: Several studies have demonstrated liposomal doxorubicin (Doxil) to be an active antineoplastic agent in platinum-resistant ovarian cancer, with dose limiting toxicity of the standard dosing regimen (50 mg/m(2) q 4 weeks) being severe erythrodysesthesia ("hand-foot syndrome") and stomatitis.	platinum	hand-foot syndrome	10985896	-1
-BACKGROUND: Several studies have demonstrated liposomal doxorubicin (Doxil) to be an active antineoplastic agent in platinum-resistant ovarian cancer, with dose limiting toxicity of the standard dosing regimen (50 mg/m(2) q 4 weeks) being severe erythrodysesthesia ("hand-foot syndrome") and stomatitis.	platinum	toxicity	10985896	-1
-BACKGROUND: Several studies have demonstrated liposomal doxorubicin (Doxil) to be an active antineoplastic agent in platinum-resistant ovarian cancer, with dose limiting toxicity of the standard dosing regimen (50 mg/m(2) q 4 weeks) being severe erythrodysesthesia ("hand-foot syndrome") and stomatitis.	platinum	stomatitis	10985896	-1
-OBJECTIVES: The present study investigates the effects of nicotine on anxiety induced by caffeine and another anxiogenic drug, pentylenetetrazole, in mice.	nicotine	anxiety	15991002	-1
-OBJECTIVES: The present study investigates the effects of nicotine on anxiety induced by caffeine and another anxiogenic drug, pentylenetetrazole, in mice.	caffeine	anxiety	15991002	1
-Neuroleptic malignant syndrome and methylphenidate.	methylphenidate	Neuroleptic malignant syndrome	9831002	1
-Early CY toxicity caused a typical haemorrhagic cystitis in both strains that was completely repaired in about 7-10 days.	CY	toxicity	12059909	-1
-Her medications included desvenlafaxine, and symptoms included nausea, anxiety and confusion.	desvenlafaxine	anxiety	24234943	1
-The role of p-aminophenol in acetaminophen-induced nephrotoxicity: effect of bis(p-nitrophenyl) phosphate on acetaminophen and p-aminophenol nephrotoxicity and metabolism in Fischer 344 rats.	p-aminophenol	nephrotoxicity	4082192	-1
-The role of p-aminophenol in acetaminophen-induced nephrotoxicity: effect of bis(p-nitrophenyl) phosphate on acetaminophen and p-aminophenol nephrotoxicity and metabolism in Fischer 344 rats.	p-aminophenol	nephrotoxicity	4082192	-1
-The role of p-aminophenol in acetaminophen-induced nephrotoxicity: effect of bis(p-nitrophenyl) phosphate on acetaminophen and p-aminophenol nephrotoxicity and metabolism in Fischer 344 rats.	acetaminophen	nephrotoxicity	4082192	-1
-The role of p-aminophenol in acetaminophen-induced nephrotoxicity: effect of bis(p-nitrophenyl) phosphate on acetaminophen and p-aminophenol nephrotoxicity and metabolism in Fischer 344 rats.	acetaminophen	nephrotoxicity	4082192	-1
-The role of p-aminophenol in acetaminophen-induced nephrotoxicity: effect of bis(p-nitrophenyl) phosphate on acetaminophen and p-aminophenol nephrotoxicity and metabolism in Fischer 344 rats.	acetaminophen	nephrotoxicity	4082192	-1
-The role of p-aminophenol in acetaminophen-induced nephrotoxicity: effect of bis(p-nitrophenyl) phosphate on acetaminophen and p-aminophenol nephrotoxicity and metabolism in Fischer 344 rats.	acetaminophen	nephrotoxicity	4082192	-1
-The role of p-aminophenol in acetaminophen-induced nephrotoxicity: effect of bis(p-nitrophenyl) phosphate on acetaminophen and p-aminophenol nephrotoxicity and metabolism in Fischer 344 rats.	phosphate	nephrotoxicity	4082192	-1
-The role of p-aminophenol in acetaminophen-induced nephrotoxicity: effect of bis(p-nitrophenyl) phosphate on acetaminophen and p-aminophenol nephrotoxicity and metabolism in Fischer 344 rats.	phosphate	nephrotoxicity	4082192	-1
-The role of p-aminophenol in acetaminophen-induced nephrotoxicity: effect of bis(p-nitrophenyl) phosphate on acetaminophen and p-aminophenol nephrotoxicity and metabolism in Fischer 344 rats.	bis(p-nitrophenyl	nephrotoxicity	4082192	-1
-The role of p-aminophenol in acetaminophen-induced nephrotoxicity: effect of bis(p-nitrophenyl) phosphate on acetaminophen and p-aminophenol nephrotoxicity and metabolism in Fischer 344 rats.	bis(p-nitrophenyl	nephrotoxicity	4082192	-1
-The role of p-aminophenol in acetaminophen-induced nephrotoxicity: effect of bis(p-nitrophenyl) phosphate on acetaminophen and p-aminophenol nephrotoxicity and metabolism in Fischer 344 rats.	aminophenol	nephrotoxicity	4082192	-1
-The role of p-aminophenol in acetaminophen-induced nephrotoxicity: effect of bis(p-nitrophenyl) phosphate on acetaminophen and p-aminophenol nephrotoxicity and metabolism in Fischer 344 rats.	aminophenol	nephrotoxicity	4082192	-1
-CONCLUSION: There was no significant difference between isotonic sodium chloride, sodium bicarbonate and isotonic sodium chloride with diltiazem application in prevention of CIN.	diltiazem	CIN	24341598	-1
-CONCLUSION: There was no significant difference between isotonic sodium chloride, sodium bicarbonate and isotonic sodium chloride with diltiazem application in prevention of CIN.	sodium bicarbonate	CIN	24341598	-1
-CONCLUSION: There was no significant difference between isotonic sodium chloride, sodium bicarbonate and isotonic sodium chloride with diltiazem application in prevention of CIN.	sodium chloride	CIN	24341598	-1
-CONCLUSION: There was no significant difference between isotonic sodium chloride, sodium bicarbonate and isotonic sodium chloride with diltiazem application in prevention of CIN.	sodium chloride	CIN	24341598	-1
-Nicotine (0.25 mg/kg) pretreatment blocked the caffeine- but not pentylenetetrazole-induced anxiety.	Nicotine	anxiety	15991002	-1
-In experiment set up 1: Memory deficit was found in Morris water maze test on 14-16 days after STZ (ICV; 3mg/Kg) administration.	STZ	Memory deficit	24333387	1
-The epidemiology of aminoglycoside-induced nephrotoxicity is not fully understood.	aminoglycoside	nephrotoxicity	3538855	1
-METHODS: The effect of pretreatment with trazodone on dexamphetamine- and apomorphine-induced oral stereotypies, on catalepsy induced by haloperidol and apomorphine (0.05 mg/kg, i.p.), on ergometrine-induced wet dog shake (WDS) behavior and fluoxetine-induced penile erections was studied in rats.	dexamphetamine-	catalepsy	15614572	-1
-METHODS: The effect of pretreatment with trazodone on dexamphetamine- and apomorphine-induced oral stereotypies, on catalepsy induced by haloperidol and apomorphine (0.05 mg/kg, i.p.), on ergometrine-induced wet dog shake (WDS) behavior and fluoxetine-induced penile erections was studied in rats.	haloperidol	catalepsy	15614572	1
-METHODS: The effect of pretreatment with trazodone on dexamphetamine- and apomorphine-induced oral stereotypies, on catalepsy induced by haloperidol and apomorphine (0.05 mg/kg, i.p.), on ergometrine-induced wet dog shake (WDS) behavior and fluoxetine-induced penile erections was studied in rats.	ergometrine	catalepsy	15614572	-1
-METHODS: The effect of pretreatment with trazodone on dexamphetamine- and apomorphine-induced oral stereotypies, on catalepsy induced by haloperidol and apomorphine (0.05 mg/kg, i.p.), on ergometrine-induced wet dog shake (WDS) behavior and fluoxetine-induced penile erections was studied in rats.	fluoxetine	catalepsy	15614572	-1
-METHODS: The effect of pretreatment with trazodone on dexamphetamine- and apomorphine-induced oral stereotypies, on catalepsy induced by haloperidol and apomorphine (0.05 mg/kg, i.p.), on ergometrine-induced wet dog shake (WDS) behavior and fluoxetine-induced penile erections was studied in rats.	trazodone	catalepsy	15614572	-1
-METHODS: The effect of pretreatment with trazodone on dexamphetamine- and apomorphine-induced oral stereotypies, on catalepsy induced by haloperidol and apomorphine (0.05 mg/kg, i.p.), on ergometrine-induced wet dog shake (WDS) behavior and fluoxetine-induced penile erections was studied in rats.	apomorphine	catalepsy	15614572	1
-In addition, the excitability of the cardiac conduction system was depressed preferentially in the atrioventricular nodal region of hearts from barium-exposed rats.	barium	depressed	3975902	-1
-Hypotension as a manifestation of cardiotoxicity in three patients receiving cisplatin and 5-fluorouracil.	5-fluorouracil	cardiotoxicity	3383127	-1
-Hypotension as a manifestation of cardiotoxicity in three patients receiving cisplatin and 5-fluorouracil.	5-fluorouracil	Hypotension	3383127	1
-Hypotension as a manifestation of cardiotoxicity in three patients receiving cisplatin and 5-fluorouracil.	cisplatin	cardiotoxicity	3383127	-1
-Hypotension as a manifestation of cardiotoxicity in three patients receiving cisplatin and 5-fluorouracil.	cisplatin	Hypotension	3383127	1
-CONCLUSIONS: Our results suggest that the antagonistic effect of nicotine on caffeine-induced anxiety is specific to caffeine, instead of a non-specific anxiolytic effect.	nicotine	anxiety	15991002	-1
-CONCLUSIONS: Our results suggest that the antagonistic effect of nicotine on caffeine-induced anxiety is specific to caffeine, instead of a non-specific anxiolytic effect.	caffeine	anxiety	15991002	1
-CONCLUSIONS: Our results suggest that the antagonistic effect of nicotine on caffeine-induced anxiety is specific to caffeine, instead of a non-specific anxiolytic effect.	caffeine	anxiety	15991002	1
-CONCLUSION: This modified liposomal doxorubicin regimen results in less toxicity (stomatitis, hand-foot syndrome) than the standard FDA-approved dose schedule.	doxorubicin	toxicity	10985896	-1
-CONCLUSION: This modified liposomal doxorubicin regimen results in less toxicity (stomatitis, hand-foot syndrome) than the standard FDA-approved dose schedule.	doxorubicin	hand-foot syndrome	10985896	1
-CONCLUSION: This modified liposomal doxorubicin regimen results in less toxicity (stomatitis, hand-foot syndrome) than the standard FDA-approved dose schedule.	FDA	stomatitis	10985896	-1
-CONCLUSION: This modified liposomal doxorubicin regimen results in less toxicity (stomatitis, hand-foot syndrome) than the standard FDA-approved dose schedule.	FDA	toxicity	10985896	-1
-CONCLUSION: This modified liposomal doxorubicin regimen results in less toxicity (stomatitis, hand-foot syndrome) than the standard FDA-approved dose schedule.	FDA	hand-foot syndrome	10985896	-1
-OBJECTIVE: We wanted to test whether assessment of both a central pain-related signal (chemo-somatosensory evoked potential, CSSEP) and a concomitantly recorded peripheral signal (negative mucosal potential, NMP) allows for separation of central and peripheral effects of NSAIDs.	NMP	pain	9272404	-1
-7 g/dL) was observed in 5.4% of patients (CD4, 165 cells/microL) and hepatitis (clinical jaundice with alanine aminotransferase > 5 times upper limits of normal) in 3.5% of patients (CD4, 260 cells/microL).	alanine	hepatitis	18422462	-1
-7 g/dL) was observed in 5.4% of patients (CD4, 165 cells/microL) and hepatitis (clinical jaundice with alanine aminotransferase > 5 times upper limits of normal) in 3.5% of patients (CD4, 260 cells/microL).	alanine	jaundice	18422462	-1
-Definite, although limited, antineoplastic activity is observed in patients with well-defined platinum- and paclitaxel-refractory ovarian cancer.	paclitaxel	ovarian cancer	10985896	-1
-Definite, although limited, antineoplastic activity is observed in patients with well-defined platinum- and paclitaxel-refractory ovarian cancer.	platinum-	ovarian cancer	10985896	-1
-This study aimed to demonstrate the induction to glomerulosclerosis in adult offspring by PCE and its intrauterine programming mechanisms.	PCE	glomerulosclerosis	25986755	-1
-Two hundred four people with epilepsy were grouped on the basis of antiepileptic drug therapy (current, previous, or no exposure to VGB).	VGB	epilepsy	19815465	-1
-In our case the therapy with zinc acetate represented an effective treatment for a Wilson's disease patient in which penicillamine-related side effects appeared.	penicillamine	Wilson's disease	17346443	-1
-In our case the therapy with zinc acetate represented an effective treatment for a Wilson's disease patient in which penicillamine-related side effects appeared.	zinc acetate	Wilson's disease	17346443	-1
-Direct thrombin inhibitors are appropriate, evidence-based alternatives to heparin in patients with a history of HIT, who need to undergo percutaneous coronary intervention.	heparin	HIT	20495512	1
-A single neurotoxic dose of methamphetamine induces a long-lasting depressive-like behaviour in mice.	methamphetamine	depressive	24072398	1
-A single neurotoxic dose of methamphetamine induces a long-lasting depressive-like behaviour in mice.	methamphetamine	neurotoxic	24072398	-1
-The safety of the zinc acetate allowed us to avoid other potentially toxic chelating drugs; this observation is in line with the growing evidence on the efficacy of the drug in the treatment of Wilson's disease.	zinc acetate	Wilson's disease	17346443	-1
-We have investigated the effects of continuous daily oral galactose (200 mg/kg/day) treatment on cognitive deficits in streptozotocin-induced (STZ-icv) rat model of sAD, tested by Morris Water Maze and Passive Avoidance test, respectively.	galactose	cognitive deficits	24055495	1
-Since most of Wilson's disease penicillamine-treated patients do not seem to develop this skin lesion, it could be conceivable that a specific genetic factor is involved in drug response.	penicillamine	Wilson's disease	17346443	-1
-Bilateral haemorrhagic infarction of the globus pallidus after cocaine and alcohol intoxication.	cocaine	Bilateral haemorrhagic infarction	19681452	-1
-Bilateral haemorrhagic infarction of the globus pallidus after cocaine and alcohol intoxication.	cocaine	alcohol intoxication	19681452	-1
-Although an infrequent complication of selective serotonin reuptake inhibitor therapy, it is important that ophthalmologists are aware that these agents can cause hypertension because this class of drugs is widely prescribed.	serotonin	hypertension	18025637	-1
-Cocaine is a risk factor for both ischemic and haemorrhagic stroke.	Cocaine	ischemic	19681452	-1
-Cocaine is a risk factor for both ischemic and haemorrhagic stroke.	Cocaine	haemorrhagic stroke	19681452	-1
-Effects of a new calcium antagonist, CD-832, on isoproterenol-induced myocardial ischemia in dogs with partial coronary stenosis.	isoproterenol	coronary stenosis	8819482	-1
-Effects of a new calcium antagonist, CD-832, on isoproterenol-induced myocardial ischemia in dogs with partial coronary stenosis.	isoproterenol	myocardial ischemia	8819482	1
-Effects of a new calcium antagonist, CD-832, on isoproterenol-induced myocardial ischemia in dogs with partial coronary stenosis.	calcium	coronary stenosis	8819482	-1
-Effects of a new calcium antagonist, CD-832, on isoproterenol-induced myocardial ischemia in dogs with partial coronary stenosis.	calcium	myocardial ischemia	8819482	-1
-We present the case of a 31-year-old man with bilateral ischemia of the globus pallidus after excessive alcohol and intranasal cocaine use.	cocaine	ischemia	19681452	-1
-We present the case of a 31-year-old man with bilateral ischemia of the globus pallidus after excessive alcohol and intranasal cocaine use.	alcohol	ischemia	19681452	-1
-BACKGROUND: In this retrospective comparative study, we aimed to compare the effectiveness of fentanyl, midazolam, and a combination of fentanyl and midazolam to prevent etomidate-induced myoclonus.	midazolam	myoclonus	24535067	-1
-BACKGROUND: In this retrospective comparative study, we aimed to compare the effectiveness of fentanyl, midazolam, and a combination of fentanyl and midazolam to prevent etomidate-induced myoclonus.	midazolam	myoclonus	24535067	-1
-BACKGROUND: In this retrospective comparative study, we aimed to compare the effectiveness of fentanyl, midazolam, and a combination of fentanyl and midazolam to prevent etomidate-induced myoclonus.	fentanyl	myoclonus	24535067	-1
-BACKGROUND: In this retrospective comparative study, we aimed to compare the effectiveness of fentanyl, midazolam, and a combination of fentanyl and midazolam to prevent etomidate-induced myoclonus.	fentanyl	myoclonus	24535067	-1
-BACKGROUND: In this retrospective comparative study, we aimed to compare the effectiveness of fentanyl, midazolam, and a combination of fentanyl and midazolam to prevent etomidate-induced myoclonus.	etomidate	myoclonus	24535067	1
-These results suggest that 1) both SOD and DMTU have protective effects on GM-mediated nephropathy, 2) the mechanisms for the protective effects differ for SOD and DMTU, and 3) superoxide anions play a critical role in GM-induced renal vasoconstriction.	GM	nephropathy	8160791	1
-These results suggest that 1) both SOD and DMTU have protective effects on GM-mediated nephropathy, 2) the mechanisms for the protective effects differ for SOD and DMTU, and 3) superoxide anions play a critical role in GM-induced renal vasoconstriction.	DMTU	nephropathy	8160791	-1
-These results suggest that 1) both SOD and DMTU have protective effects on GM-mediated nephropathy, 2) the mechanisms for the protective effects differ for SOD and DMTU, and 3) superoxide anions play a critical role in GM-induced renal vasoconstriction.	DMTU	nephropathy	8160791	-1
-These results suggest that 1) both SOD and DMTU have protective effects on GM-mediated nephropathy, 2) the mechanisms for the protective effects differ for SOD and DMTU, and 3) superoxide anions play a critical role in GM-induced renal vasoconstriction.	superoxide	nephropathy	8160791	-1
-Drug-related globus pallidus infarctions are most often associated with heroin.	heroin	infarctions	19681452	-1
-Pretreatment of animals with BNPP prior to APAP or PAP administration resulted in marked reduction of APAP (900 mg/kg) nephrotoxicity but not PAP nephrotoxicity.	PAP	nephrotoxicity	4082192	-1
-Pretreatment of animals with BNPP prior to APAP or PAP administration resulted in marked reduction of APAP (900 mg/kg) nephrotoxicity but not PAP nephrotoxicity.	PAP	nephrotoxicity	4082192	-1
-Pretreatment of animals with BNPP prior to APAP or PAP administration resulted in marked reduction of APAP (900 mg/kg) nephrotoxicity but not PAP nephrotoxicity.	PAP	nephrotoxicity	4082192	-1
-Pretreatment of animals with BNPP prior to APAP or PAP administration resulted in marked reduction of APAP (900 mg/kg) nephrotoxicity but not PAP nephrotoxicity.	PAP	nephrotoxicity	4082192	-1
-Pretreatment of animals with BNPP prior to APAP or PAP administration resulted in marked reduction of APAP (900 mg/kg) nephrotoxicity but not PAP nephrotoxicity.	BNPP	nephrotoxicity	4082192	-1
-Pretreatment of animals with BNPP prior to APAP or PAP administration resulted in marked reduction of APAP (900 mg/kg) nephrotoxicity but not PAP nephrotoxicity.	BNPP	nephrotoxicity	4082192	-1
-Pretreatment of animals with BNPP prior to APAP or PAP administration resulted in marked reduction of APAP (900 mg/kg) nephrotoxicity but not PAP nephrotoxicity.	APAP	nephrotoxicity	4082192	-1
-Pretreatment of animals with BNPP prior to APAP or PAP administration resulted in marked reduction of APAP (900 mg/kg) nephrotoxicity but not PAP nephrotoxicity.	APAP	nephrotoxicity	4082192	-1
-Pretreatment of animals with BNPP prior to APAP or PAP administration resulted in marked reduction of APAP (900 mg/kg) nephrotoxicity but not PAP nephrotoxicity.	APAP	nephrotoxicity	4082192	-1
-Pretreatment of animals with BNPP prior to APAP or PAP administration resulted in marked reduction of APAP (900 mg/kg) nephrotoxicity but not PAP nephrotoxicity.	APAP	nephrotoxicity	4082192	-1
-Bilateral basal ganglia infarcts after the use of cocaine, without concurrent heroin use, have never been reported.	heroin	ganglia infarcts	19681452	-1
-Bilateral basal ganglia infarcts after the use of cocaine, without concurrent heroin use, have never been reported.	cocaine	ganglia infarcts	19681452	-1
-Methamphetamine (METH) triggers a disruption of the monoaminergic system and METH abuse leads to negative emotional states including depressive symptoms during drug withdrawal.	METH	depressive symptoms	24072398	1
-Methamphetamine (METH) triggers a disruption of the monoaminergic system and METH abuse leads to negative emotional states including depressive symptoms during drug withdrawal.	METH	depressive symptoms	24072398	1
-A 62-year-old man was found to have bradycardia, hypothermia and respiratory failure 3 weeks after initiation of amiodarone therapy for atrial fibrillation.	amiodarone	hypothermia	24729111	1
-A 62-year-old man was found to have bradycardia, hypothermia and respiratory failure 3 weeks after initiation of amiodarone therapy for atrial fibrillation.	amiodarone	atrial fibrillation	24729111	-1
-In our patient, transient cardiac arrhythmia or respiratory dysfunction related to cocaine and/or ethanol use were the most likely causes of cerebral hypoperfusion.	cocaine	cardiac arrhythmia	19681452	-1
-In our patient, transient cardiac arrhythmia or respiratory dysfunction related to cocaine and/or ethanol use were the most likely causes of cerebral hypoperfusion.	cocaine	respiratory dysfunction	19681452	-1
-In our patient, transient cardiac arrhythmia or respiratory dysfunction related to cocaine and/or ethanol use were the most likely causes of cerebral hypoperfusion.	cocaine	cerebral hypoperfusion	19681452	-1
-In our patient, transient cardiac arrhythmia or respiratory dysfunction related to cocaine and/or ethanol use were the most likely causes of cerebral hypoperfusion.	ethanol	cardiac arrhythmia	19681452	-1
-In our patient, transient cardiac arrhythmia or respiratory dysfunction related to cocaine and/or ethanol use were the most likely causes of cerebral hypoperfusion.	ethanol	respiratory dysfunction	19681452	-1
-In our patient, transient cardiac arrhythmia or respiratory dysfunction related to cocaine and/or ethanol use were the most likely causes of cerebral hypoperfusion.	ethanol	cerebral hypoperfusion	19681452	-1
-Among the patients with 1 year of follow-up, NVP therapy was significantly associated with developing rash and d4T therapy with developing peripheral neuropathy (p < 0.05).	NVP	peripheral neuropathy	18422462	-1
-MAIN OUTCOME MEASURES: Fasting plasma glucose and fasting serum insulin levels, insulin sensitivity index, homeostasis model assessment of insulin resistance, and glucose effectiveness.	glucose	glucose effectiveness	15630069	-1
-Eighty-one consecutive patients (54 with coronary artery disease, and 20 with dilated cardiomyopathy) with inducible sustained ventricular tachycardia or ventricular fibrillation received oral d,l-sotalol to prevent induction of the ventricular tachyarrhythmia.	l-sotalol	dilated cardiomyopathy	9125676	-1
-Eighty-one consecutive patients (54 with coronary artery disease, and 20 with dilated cardiomyopathy) with inducible sustained ventricular tachycardia or ventricular fibrillation received oral d,l-sotalol to prevent induction of the ventricular tachyarrhythmia.	l-sotalol	ventricular fibrillation	9125676	-1
-Eighty-one consecutive patients (54 with coronary artery disease, and 20 with dilated cardiomyopathy) with inducible sustained ventricular tachycardia or ventricular fibrillation received oral d,l-sotalol to prevent induction of the ventricular tachyarrhythmia.	l-sotalol	coronary artery disease	9125676	-1
-Eighty-one consecutive patients (54 with coronary artery disease, and 20 with dilated cardiomyopathy) with inducible sustained ventricular tachycardia or ventricular fibrillation received oral d,l-sotalol to prevent induction of the ventricular tachyarrhythmia.	l-sotalol	ventricular tachycardia	9125676	-1
-Eighty-one consecutive patients (54 with coronary artery disease, and 20 with dilated cardiomyopathy) with inducible sustained ventricular tachycardia or ventricular fibrillation received oral d,l-sotalol to prevent induction of the ventricular tachyarrhythmia.	l-sotalol	ventricular tachyarrhythmia	9125676	-1
-The aim of this study is to investigate and compare the protective effects of isotonic sodium chloride with sodium bicarbonate infusion and isotonic sodium chloride infusion with diltiazem, a calcium channel blocker, in preventing CIN.	diltiazem	CIN	24341598	-1
-The aim of this study is to investigate and compare the protective effects of isotonic sodium chloride with sodium bicarbonate infusion and isotonic sodium chloride infusion with diltiazem, a calcium channel blocker, in preventing CIN.	sodium bicarbonate	CIN	24341598	-1
-The aim of this study is to investigate and compare the protective effects of isotonic sodium chloride with sodium bicarbonate infusion and isotonic sodium chloride infusion with diltiazem, a calcium channel blocker, in preventing CIN.	sodium chloride	CIN	24341598	-1
-The aim of this study is to investigate and compare the protective effects of isotonic sodium chloride with sodium bicarbonate infusion and isotonic sodium chloride infusion with diltiazem, a calcium channel blocker, in preventing CIN.	sodium chloride	CIN	24341598	-1
-The aim of this study is to investigate and compare the protective effects of isotonic sodium chloride with sodium bicarbonate infusion and isotonic sodium chloride infusion with diltiazem, a calcium channel blocker, in preventing CIN.	calcium	CIN	24341598	-1
-Three young infants, all of birth weight < 1,500 g, experienced myoclonus following the intravenous administration of lorazepam.	lorazepam	myoclonus	7727612	1
-Paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) by 3-hour infusion was combined with carboplatin in a phase I/II study directed to patients with non-small cell lung cancer.	Paclitaxel	non-small cell lung cancer	7644931	-1
-Paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) by 3-hour infusion was combined with carboplatin in a phase I/II study directed to patients with non-small cell lung cancer.	Taxol	non-small cell lung cancer	7644931	-1
-Paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) by 3-hour infusion was combined with carboplatin in a phase I/II study directed to patients with non-small cell lung cancer.	carboplatin	non-small cell lung cancer	7644931	-1
-We conclude that an H1 antagonist may be useful in preventing hypotension caused by iv cimetidine, since the vasodilating activity of cimetidine is mediated, in part, through the H1 receptor.	cimetidine	hypotension	2021990	1
-We conclude that an H1 antagonist may be useful in preventing hypotension caused by iv cimetidine, since the vasodilating activity of cimetidine is mediated, in part, through the H1 receptor.	cimetidine	hypotension	2021990	1
-Postthrombectomy continuous CDT with alteplase was commenced while argatroban was withheld, and complete patency of the SVC and central veins was achieved after three days of therapy.	argatroban	SVC	24733133	-1
-We conclude that the dipyridamole ECG test is as useful as the exercise ECG test for the assessment of coronary artery disease.	dipyridamole	coronary artery disease	3746148	-1
-The dose-dependent effect of misoprostol on indomethacin-induced renal dysfunction in well compensated cirrhosis.	misoprostol	renal dysfunction	7661171	-1
-The dose-dependent effect of misoprostol on indomethacin-induced renal dysfunction in well compensated cirrhosis.	misoprostol	cirrhosis	7661171	-1
-The dose-dependent effect of misoprostol on indomethacin-induced renal dysfunction in well compensated cirrhosis.	indomethacin	renal dysfunction	7661171	1
-The dose-dependent effect of misoprostol on indomethacin-induced renal dysfunction in well compensated cirrhosis.	indomethacin	cirrhosis	7661171	-1
-p75NTR expression in rat urinary bladder sensory neurons and spinal cord with cyclophosphamide-induced cystitis.	cyclophosphamide	cystitis	18189308	1
-Those of myalgia tend to decrease according to increasing the amount of precurarizing dose of rocuronium, but there was no significance (P = 0.072).	rocuronium	myalgia	25006369	-1
-Dermal administration of S-23121 at 800 mg/kg resulted in an increased incidence of embryonic death and ventricular septal defect, but retarded fetal growth was not observed as it was following oral exposure to S-23121.	S-23121	ventricular septal defect	24753331	1
-Dermal administration of S-23121 at 800 mg/kg resulted in an increased incidence of embryonic death and ventricular septal defect, but retarded fetal growth was not observed as it was following oral exposure to S-23121.	S-23121	embryonic death	24753331	-1
-Dermal administration of S-23121 at 800 mg/kg resulted in an increased incidence of embryonic death and ventricular septal defect, but retarded fetal growth was not observed as it was following oral exposure to S-23121.	S-23121	ventricular septal defect	24753331	1
-Dermal administration of S-23121 at 800 mg/kg resulted in an increased incidence of embryonic death and ventricular septal defect, but retarded fetal growth was not observed as it was following oral exposure to S-23121.	S-23121	embryonic death	24753331	-1
-Thus, temsirolimus reduced tumor burden through associated cytostatic and anti-angiogenic effects.	temsirolimus	tumor	20828385	-1
-Of the 407 Yellow Card records analysed, 106 satisfied criteria for TDF-related kidney disease, of which 53 (50%) had features of kidney tubular dysfunction, 35 (33%) were found to have features of glomerular dysfunction and 18 (17%) had Fanconi syndrome.	TDF	Fanconi syndrome	24067251	1
-Of the 407 Yellow Card records analysed, 106 satisfied criteria for TDF-related kidney disease, of which 53 (50%) had features of kidney tubular dysfunction, 35 (33%) were found to have features of glomerular dysfunction and 18 (17%) had Fanconi syndrome.	TDF	kidney disease	24067251	-1
-Of the 407 Yellow Card records analysed, 106 satisfied criteria for TDF-related kidney disease, of which 53 (50%) had features of kidney tubular dysfunction, 35 (33%) were found to have features of glomerular dysfunction and 18 (17%) had Fanconi syndrome.	TDF	kidney tubular dysfunction	24067251	-1
-Of the 407 Yellow Card records analysed, 106 satisfied criteria for TDF-related kidney disease, of which 53 (50%) had features of kidney tubular dysfunction, 35 (33%) were found to have features of glomerular dysfunction and 18 (17%) had Fanconi syndrome.	TDF	glomerular dysfunction	24067251	-1
-We report a case of a 40-year-old female with acetaminophen-induced fulminant liver failure with associated AKI who underwent intraoperative dialytic support during liver transplantation anticoagulated with citrate dialysate during the entire procedure.	acetaminophen	fulminant liver failure	19515070	-1
-We report a case of a 40-year-old female with acetaminophen-induced fulminant liver failure with associated AKI who underwent intraoperative dialytic support during liver transplantation anticoagulated with citrate dialysate during the entire procedure.	citrate	AKI	19515070	-1
-We report a case of a 40-year-old female with acetaminophen-induced fulminant liver failure with associated AKI who underwent intraoperative dialytic support during liver transplantation anticoagulated with citrate dialysate during the entire procedure.	citrate	fulminant liver failure	19515070	-1
-Nafcillin was discontinued and daptomycin 9 mg/kg daily was initiated for suspected meningitis and was continued until the patient's death on day 16.	daptomycin	meningitis	20959502	-1
-Nafcillin was discontinued and daptomycin 9 mg/kg daily was initiated for suspected meningitis and was continued until the patient's death on day 16.	Nafcillin	meningitis	20959502	-1
-Succimer chelation improves learning, attention, and arousal regulation in lead-exposed rats but produces lasting cognitive impairment in the absence of lead exposure.	lead	cognitive impairment	17384765	-1
-Succimer chelation improves learning, attention, and arousal regulation in lead-exposed rats but produces lasting cognitive impairment in the absence of lead exposure.	lead	cognitive impairment	17384765	-1
-The incidence of hospitalisation for TDF kidney adverse effects was high, particularly amongst patients with features of Fanconi syndrome.	TDF	Fanconi syndrome	24067251	1
-Behavioral and neurochemical studies in mice pretreated with garcinielliptone FC in pilocarpine-induced seizures. Garcinielliptone FC (GFC)	garcinielliptone FC	seizures	24911645	-1
-Behavioral and neurochemical studies in mice pretreated with garcinielliptone FC in pilocarpine-induced seizures. Garcinielliptone FC (GFC)	Garcinielliptone FC	seizures	24911645	-1
-Behavioral and neurochemical studies in mice pretreated with garcinielliptone FC in pilocarpine-induced seizures. Garcinielliptone FC (GFC)	GFC	seizures	24911645	-1
-Behavioral and neurochemical studies in mice pretreated with garcinielliptone FC in pilocarpine-induced seizures. Garcinielliptone FC (GFC)	pilocarpine	seizures	24911645	1
-Sub-chronic inhibition of nitric-oxide synthesis modifies haloperidol-induced catalepsy and the number of NADPH-diaphorase neurons in mice.	haloperidol	catalepsy	10672628	1
-Sub-chronic inhibition of nitric-oxide synthesis modifies haloperidol-induced catalepsy and the number of NADPH-diaphorase neurons in mice.	nitric-oxide	catalepsy	10672628	-1
-Sub-chronic inhibition of nitric-oxide synthesis modifies haloperidol-induced catalepsy and the number of NADPH-diaphorase neurons in mice.	NADPH	catalepsy	10672628	-1
-RATIONALE: NG-nitro-L-arginine (L-NOARG), an inhibitor of nitric-oxide synthase (NOS), induces catalepsy in mice.	nitric-oxide	catalepsy	10672628	-1
-Although all of the currently available H2-receptor antagonists have shown the propensity to cause delirium, only two previously reported cases have been associated with famotidine.	famotidine	delirium	8701013	1
-Among users of third-generation progestagens, the risk of VTE was higher in users of desogestrel with 20 g ethinyloestradiol than in users of gestodene or desogestrel with 30 g ethinyloestradiol.	progestagens	VTE	8996419	-1
-Among users of third-generation progestagens, the risk of VTE was higher in users of desogestrel with 20 g ethinyloestradiol than in users of gestodene or desogestrel with 30 g ethinyloestradiol.	desogestrel	VTE	8996419	-1
-Among users of third-generation progestagens, the risk of VTE was higher in users of desogestrel with 20 g ethinyloestradiol than in users of gestodene or desogestrel with 30 g ethinyloestradiol.	desogestrel	VTE	8996419	-1
-Among users of third-generation progestagens, the risk of VTE was higher in users of desogestrel with 20 g ethinyloestradiol than in users of gestodene or desogestrel with 30 g ethinyloestradiol.	gestodene	VTE	8996419	-1
-Among users of third-generation progestagens, the risk of VTE was higher in users of desogestrel with 20 g ethinyloestradiol than in users of gestodene or desogestrel with 30 g ethinyloestradiol.	ethinyloestradiol	VTE	8996419	-1
-Among users of third-generation progestagens, the risk of VTE was higher in users of desogestrel with 20 g ethinyloestradiol than in users of gestodene or desogestrel with 30 g ethinyloestradiol.	ethinyloestradiol	VTE	8996419	-1
-The patient tolerated the procedure well without any signs of citrate toxicity and maintained adequate anticoagulation for patency of the dialysis circuit.	citrate	toxicity	19515070	-1
-There was no change in hepatic tissue total glutathione following intestinal ischemia-reperfusion injury.	glutathione	intestinal ischemia-reperfusion injury	1943082	-1
-We also investigated whether trazodone induces catalepsy in rats.	trazodone	catalepsy	15614572	-1
-CONCLUSION: Our data suggest that Asian patients may be at increased risk of hyponatremia and/or SIADH associated with vincristine use.	vincristine	hyponatremia	12051122	1
-PURPOSE: To determine the natural history of visual field defects in a group of patients known to have Vigabatrin-associated changes who elected to continue the medication because of good seizure control.	Vigabatrin	seizure	15094729	-1
-PURPOSE: To determine the natural history of visual field defects in a group of patients known to have Vigabatrin-associated changes who elected to continue the medication because of good seizure control.	Vigabatrin	visual field defects	15094729	-1
-The use of thiopentone was significantly associated with an eight-fold-higher risk for delirium compared to propofol (57.1% vs. 7.1%, RR = 8.0, X2 = 4.256; df = 1; 0.05 < p < 0.02). CONCLUSION: In this study early postoperative delirium was found to be a very common complication after major surgery, even in a population without known risk factors.	propofol	delirium	24068571	-1
-The use of thiopentone was significantly associated with an eight-fold-higher risk for delirium compared to propofol (57.1% vs. 7.1%, RR = 8.0, X2 = 4.256; df = 1; 0.05 < p < 0.02). CONCLUSION: In this study early postoperative delirium was found to be a very common complication after major surgery, even in a population without known risk factors.	propofol	postoperative delirium	24068571	-1
-The use of thiopentone was significantly associated with an eight-fold-higher risk for delirium compared to propofol (57.1% vs. 7.1%, RR = 8.0, X2 = 4.256; df = 1; 0.05 < p < 0.02). CONCLUSION: In this study early postoperative delirium was found to be a very common complication after major surgery, even in a population without known risk factors.	thiopentone	postoperative delirium	24068571	1
-We have previously reported that CCK-8 significantly alleviated morphine-induced amnesia and reversed spine density decreases in the CA1 region of the hippocampus in morphine-treated animals.	CCK-8	amnesia	24309294	-1
-We have previously reported that CCK-8 significantly alleviated morphine-induced amnesia and reversed spine density decreases in the CA1 region of the hippocampus in morphine-treated animals.	morphine	amnesia	24309294	1
-Citrate dialysate is a safe alternative for intradialytic support of liver transplantation in fulminant liver failure.	Citrate	fulminant liver failure	19515070	-1
-Val204Asp) causes loss of activity and prolonged apnea with suxamethonium.	suxamethonium	apnea	25054547	1
-Rechallenge of patients who developed oral candidiasis or hoarseness with beclomethasone dipropionate.	beclomethasone dipropionate	oral candidiasis	3475563	1
-Clonazepam monotherapy for epilepsy in childhood.	Clonazepam	epilepsy	3832950	-1
-Co-administration of nefiracetam and apomorphine during training or 10h thereafter produced no significant anti-amnesic effect.	nefiracetam	amnesic	8829135	-1
-Co-administration of nefiracetam and apomorphine during training or 10h thereafter produced no significant anti-amnesic effect.	apomorphine	amnesic	8829135	1
-Overall, galantamine was well-tolerated, with no significant adverse effects apart from headaches in one patient.	galantamine	headaches	17069550	1
-CONCLUSION: A 63-year-old man with renal amyloidosis and SVC syndrome secondary to HITT was successfully treated with argatroban and CDT with alteplase.	argatroban	HITT	24733133	-1
-CONCLUSION: A 63-year-old man with renal amyloidosis and SVC syndrome secondary to HITT was successfully treated with argatroban and CDT with alteplase.	argatroban	SVC syndrome	24733133	-1
-CONCLUSION: A 63-year-old man with renal amyloidosis and SVC syndrome secondary to HITT was successfully treated with argatroban and CDT with alteplase.	argatroban	renal amyloidosis	24733133	-1
-The risk and associated factors of methamphetamine psychosis in methamphetamine-dependent patients in Malaysia.	methamphetamine	psychosis	23433219	1
-The risk and associated factors of methamphetamine psychosis in methamphetamine-dependent patients in Malaysia.	methamphetamine	psychosis	23433219	1
-CONCLUSION: In this open trial, galantamine was well-tolerated and appeared to be beneficial for the treatment of interfering behaviors in children with autism, particularly aggression, behavioral dyscontrol, and inattention.	galantamine	aggression	17069550	-1
-CONCLUSION: In this open trial, galantamine was well-tolerated and appeared to be beneficial for the treatment of interfering behaviors in children with autism, particularly aggression, behavioral dyscontrol, and inattention.	galantamine	autism	17069550	-1
-Decreased Expression of Na/K-ATPase, NHE3, NBC1, AQP1 and OAT in Gentamicin-induced Nephropathy.	Gentamicin	OAT	19967075	-1
-Decreased Expression of Na/K-ATPase, NHE3, NBC1, AQP1 and OAT in Gentamicin-induced Nephropathy.	K	OAT	19967075	-1
-Decreased Expression of Na/K-ATPase, NHE3, NBC1, AQP1 and OAT in Gentamicin-induced Nephropathy.	K	Nephropathy	19967075	-1
-Decreased Expression of Na/K-ATPase, NHE3, NBC1, AQP1 and OAT in Gentamicin-induced Nephropathy.	Na	OAT	19967075	-1
-Decreased Expression of Na/K-ATPase, NHE3, NBC1, AQP1 and OAT in Gentamicin-induced Nephropathy.	Na	Nephropathy	19967075	-1
-Effects of CD-832 on isoproterenol (ISO)-induced myocardial ischemia were studied in dogs with partial coronary stenosis of the left circumflex coronary artery and findings were compared with those for nifedipine or diltiazem.	diltiazem	coronary stenosis	8819482	-1
-Effects of CD-832 on isoproterenol (ISO)-induced myocardial ischemia were studied in dogs with partial coronary stenosis of the left circumflex coronary artery and findings were compared with those for nifedipine or diltiazem.	diltiazem	myocardial ischemia	8819482	-1
-Effects of CD-832 on isoproterenol (ISO)-induced myocardial ischemia were studied in dogs with partial coronary stenosis of the left circumflex coronary artery and findings were compared with those for nifedipine or diltiazem.	isoproterenol	coronary stenosis	8819482	-1
-Effects of CD-832 on isoproterenol (ISO)-induced myocardial ischemia were studied in dogs with partial coronary stenosis of the left circumflex coronary artery and findings were compared with those for nifedipine or diltiazem.	ISO)-induced	coronary stenosis	8819482	-1
-Effects of CD-832 on isoproterenol (ISO)-induced myocardial ischemia were studied in dogs with partial coronary stenosis of the left circumflex coronary artery and findings were compared with those for nifedipine or diltiazem.	ISO)-induced	myocardial ischemia	8819482	1
-Effects of CD-832 on isoproterenol (ISO)-induced myocardial ischemia were studied in dogs with partial coronary stenosis of the left circumflex coronary artery and findings were compared with those for nifedipine or diltiazem.	nifedipine	coronary stenosis	8819482	-1
-Effects of CD-832 on isoproterenol (ISO)-induced myocardial ischemia were studied in dogs with partial coronary stenosis of the left circumflex coronary artery and findings were compared with those for nifedipine or diltiazem.	nifedipine	myocardial ischemia	8819482	-1
-These results indicate that delayed toxicity of CY in female DBA/2 mice causes a bladder pathology that is not observed in C57BL/6 mice.	CY	toxicity	12059909	-1
-Caffeine challenge test in panic disorder and depression with panic attacks.	Caffeine	depression	17445520	-1
-Caffeine challenge test in panic disorder and depression with panic attacks.	Caffeine	panic disorder	17445520	1
-Clinical safety of lidocaine in patients with cocaine-associated myocardial infarction.	lidocaine	myocardial infarction	7492040	-1
-Light microscopic evidence of renal damage was seen above a dose of 0.5 mg doxorubicin/kg, which resulted in albuminuria and very low serum albumin levels.	doxorubicin	renal damage	6585590	-1
-Light microscopic evidence of renal damage was seen above a dose of 0.5 mg doxorubicin/kg, which resulted in albuminuria and very low serum albumin levels.	doxorubicin	albuminuria	6585590	1
-Major bleeding is of primary concern in patients receiving heparin therapy.	heparin	bleeding	10726030	-1
-Cytostatic and anti-angiogenic effects of temsirolimus in refractory mantle cell lymphoma.	temsirolimus	mantle cell lymphoma	20828385	-1
-Extensive literature search revealed multiple cases of coronary artery vasospasm secondary to zolmitriptan, but none of the cases were associated with TS.	zolmitriptan	TS	24100257	1
-Extensive literature search revealed multiple cases of coronary artery vasospasm secondary to zolmitriptan, but none of the cases were associated with TS.	zolmitriptan	coronary artery vasospasm	24100257	-1
-Myotonia congenita (MC) is caused by a defect in the skeletal muscle chloride channel function, which may cause sustained membrane depolarisation.	chloride	Myotonia congenita	12699527	-1
-Myotonia congenita (MC) is caused by a defect in the skeletal muscle chloride channel function, which may cause sustained membrane depolarisation.	chloride	MC	12699527	-1
-Since intravascular fibrin thrombi are often observed in patients with fibrinolytic disorders, EACA should not be implicated in the pathogenesis of fibrin thrombi in patients with disseminated intravascular coagulation or other "consumption coagulopathies."	EACA	coagulopathies	448423	-1
-Since intravascular fibrin thrombi are often observed in patients with fibrinolytic disorders, EACA should not be implicated in the pathogenesis of fibrin thrombi in patients with disseminated intravascular coagulation or other "consumption coagulopathies."	EACA	intravascular coagulation	448423	-1
-Since intravascular fibrin thrombi are often observed in patients with fibrinolytic disorders, EACA should not be implicated in the pathogenesis of fibrin thrombi in patients with disseminated intravascular coagulation or other "consumption coagulopathies."	EACA	fibrinolytic disorders	448423	-1
-Since intravascular fibrin thrombi are often observed in patients with fibrinolytic disorders, EACA should not be implicated in the pathogenesis of fibrin thrombi in patients with disseminated intravascular coagulation or other "consumption coagulopathies."	EACA	thrombi	448423	1
-The protective role of betaine on myocardial damage was further confirmed by histopathological examination.	betaine	myocardial damage	25080425	-1
-After fluoxetine treatment, there was a significant 47% improvement (p < 0.05) of apomorphine-induced dyskinesias without modification of parkinsonian motor disability.	fluoxetine	parkinsonian	7477981	-1
-After fluoxetine treatment, there was a significant 47% improvement (p < 0.05) of apomorphine-induced dyskinesias without modification of parkinsonian motor disability.	fluoxetine	dyskinesias	7477981	1
-After fluoxetine treatment, there was a significant 47% improvement (p < 0.05) of apomorphine-induced dyskinesias without modification of parkinsonian motor disability.	apomorphine	parkinsonian	7477981	-1
-We describe a previously healthy 32-year-old woman who developed a life-threatening muscle spasm and secondary ventilation difficulties following a preoperative injection of suxamethonium.	suxamethonium	muscle spasm	12699527	1
-Fatal carbamazepine induced fulminant eosinophilic (hypersensitivity) myocarditis: emphasis on anatomical and histological characteristics, mechanisms and genetics of drug hypersensitivity and differential diagnosis.	carbamazepine	hypersensitivity	20129423	1
-Fatal carbamazepine induced fulminant eosinophilic (hypersensitivity) myocarditis: emphasis on anatomical and histological characteristics, mechanisms and genetics of drug hypersensitivity and differential diagnosis.	carbamazepine	myocarditis	20129423	1
-BACKGROUND: Studies on the association between the long-term use of aspirin and other analgesic and nonsteroidal anti-inflammatory drugs (NSAIDs) and end-stage renal disease (ESRD) have given conflicting results.	aspirin	end-stage renal disease	15882284	1
-BACKGROUND: Studies on the association between the long-term use of aspirin and other analgesic and nonsteroidal anti-inflammatory drugs (NSAIDs) and end-stage renal disease (ESRD) have given conflicting results.	aspirin	ESRD	15882284	1
-This illustrates intravenous pamidronate as a valuable therapeutic tool when milk-alkali syndrome presents as hypercalcemic emergency.	pamidronate	milk-alkali syndrome	8667442	-1
-This illustrates intravenous pamidronate as a valuable therapeutic tool when milk-alkali syndrome presents as hypercalcemic emergency.	pamidronate	hypercalcemic emergency	8667442	-1
-The withdrawal and the gradual reintroduction of quetiapine 2 weeks later, which led to another severe agitation, enabled us to attribute the agitation specifically to quetiapine.	quetiapine	agitation	24582773	1
-STUDY OBJECTIVE: To evaluate the safety of lidocaine in the setting of cocaine-induced myocardial infarction (MI).	lidocaine	myocardial infarction	7492040	-1
-STUDY OBJECTIVE: To evaluate the safety of lidocaine in the setting of cocaine-induced myocardial infarction (MI).	lidocaine	MI	7492040	-1
-STUDY OBJECTIVE: To evaluate the safety of lidocaine in the setting of cocaine-induced myocardial infarction (MI).	cocaine	myocardial infarction	7492040	1
-STUDY OBJECTIVE: To evaluate the safety of lidocaine in the setting of cocaine-induced myocardial infarction (MI).	cocaine	MI	7492040	1
-Among 3,129 dobutamine stress echocardiographic studies, a hypertensive response, defined as systolic blood pressure (BP) > or = 220 mm Hg and/or diastolic BP > or = 110 mm Hg, occurred in 30 patients (1%).	3,129 dobutamine	hypertensive	9382023	1
-Treatment of ovarian cancer with a combination of cis-platinum, adriamycin, cyclophosphamide and hexamethylmelamine.	adriamycin	ovarian cancer	6806735	-1
-Treatment of ovarian cancer with a combination of cis-platinum, adriamycin, cyclophosphamide and hexamethylmelamine.	cyclophosphamide	ovarian cancer	6806735	-1
-Treatment of ovarian cancer with a combination of cis-platinum, adriamycin, cyclophosphamide and hexamethylmelamine.	cis-platinum	ovarian cancer	6806735	-1
-Treatment of ovarian cancer with a combination of cis-platinum, adriamycin, cyclophosphamide and hexamethylmelamine.	hexamethylmelamine	ovarian cancer	6806735	-1
-Haloperidol failed to prevent amphetamine-induced seizures, but did lower the mortality rate at most doses tested.	Haloperidol	seizures	2625524	-1
-Haloperidol failed to prevent amphetamine-induced seizures, but did lower the mortality rate at most doses tested.	amphetamine	seizures	2625524	1
-We hypothesized that cocaine abuse may lead to altered mitochondrial function that in turn may cause left ventricular dysfunction.	cocaine	left ventricular dysfunction	20566328	-1
-RESULTS: We observed elevated lung cancer risks (N=283) among applicators with the greatest number of LT (RR=1.60; 95% CI 1.11 to 2.31; Ptrend=0.02) and IW days of diazinon use (RR=1.41; 95% CI 0.98 to 2.04; Ptrend=0.08).	diazinon	lung cancer	25907210	1
-Our data suggest that there is an association between panic attacks, no matter if associated with PD or MDP, and hyperreactivity to an oral caffeine challenge test.	caffeine	MDP	17445520	-1
-Our data suggest that there is an association between panic attacks, no matter if associated with PD or MDP, and hyperreactivity to an oral caffeine challenge test.	caffeine	PD	17445520	1
-Indomethacin-induced hyperkalemia in three patients with gouty arthritis.	Indomethacin	gouty arthritis	7411769	-1
-CONCLUSIONS: PTU therapy may be related to the appearance of MPO-ANCA, but MPO-ANCA does not appear to be closely related to vasculitis.	PTU	vasculitis	11380496	-1
-Bradycardia after high-dose intravenous methylprednisolone therapy.	methylprednisolone	Bradycardia	3798047	1
-Liver-specific ablation of integrin-linked kinase in mice results in enhanced and prolonged cell proliferation and hepatomegaly after phenobarbital administration.	phenobarbital	hepatomegaly	19920070	1
-The risk of ESRD associated with aspirin was related to the cumulated dose and duration of use, and it was particularly high among the subset of patients with vascular nephropathy as underlying disease [2.35 (1.17-4.72)].	aspirin	vascular nephropathy	15882284	-1
-CONCLUSIONS: High-dose daptomycin may be an alternative option for MSSA bacteremia with or without a CNS source in patients who have failed or cannot tolerate standard therapy.	daptomycin	bacteremia	20959502	-1
-CONCLUSIONS: High-dose daptomycin may be an alternative option for MSSA bacteremia with or without a CNS source in patients who have failed or cannot tolerate standard therapy.	MSSA	bacteremia	20959502	-1
-A rat model of IUGR was established by PCE, male fetuses and adult offspring at the age of postnatal week 24 were euthanized.	PCE	IUGR	25986755	1
-The boy had been treated with intravenous methyldopa during a trauma admission seven weeks prior to presentation.	methyldopa	trauma	2320485	-1
-The rapid reversion after insulin treatment excludes the possibility that streptozotocin in itself causes the ISO resistance and points towards a direct insulin effect on myocardial catecholamine sensitivity in diabetic rats.	streptozotocin	diabetic	3155884	1
-The rapid reversion after insulin treatment excludes the possibility that streptozotocin in itself causes the ISO resistance and points towards a direct insulin effect on myocardial catecholamine sensitivity in diabetic rats.	catecholamine	diabetic	3155884	-1
-The rapid reversion after insulin treatment excludes the possibility that streptozotocin in itself causes the ISO resistance and points towards a direct insulin effect on myocardial catecholamine sensitivity in diabetic rats.	ISO	diabetic	3155884	-1
-Epsilon aminocaproic acid (EACA) has been used to prevent rebleeding in patients with subarachnoid hemorrhage (SAH).	Epsilon aminocaproic acid	subarachnoid hemorrhage	448423	1
-Epsilon aminocaproic acid (EACA) has been used to prevent rebleeding in patients with subarachnoid hemorrhage (SAH).	Epsilon aminocaproic acid	SAH	448423	1
-Epsilon aminocaproic acid (EACA) has been used to prevent rebleeding in patients with subarachnoid hemorrhage (SAH).	EACA	subarachnoid hemorrhage	448423	1
-Epsilon aminocaproic acid (EACA) has been used to prevent rebleeding in patients with subarachnoid hemorrhage (SAH).	EACA	SAH	448423	1
-Systemic anticoagulation is unsafe and regional citrate anticoagulation in the absence of a functional liver carries the risk of citrate toxicity.	citrate	toxicity	19515070	-1
-Systemic anticoagulation is unsafe and regional citrate anticoagulation in the absence of a functional liver carries the risk of citrate toxicity.	citrate	toxicity	19515070	-1
-A prospective, open-label trial of galantamine in autistic disorder.	galantamine	autistic disorder	17069550	-1
-Neuroleptic malignant syndrome induced by combination therapy with tetrabenazine and tiapride in a Japanese patient with Huntington's disease at the terminal stage of recurrent breast cancer.	tiapride	Huntington's disease	24881749	-1
-Neuroleptic malignant syndrome induced by combination therapy with tetrabenazine and tiapride in a Japanese patient with Huntington's disease at the terminal stage of recurrent breast cancer.	tiapride	Neuroleptic malignant syndrome	24881749	1
-Neuroleptic malignant syndrome induced by combination therapy with tetrabenazine and tiapride in a Japanese patient with Huntington's disease at the terminal stage of recurrent breast cancer.	tiapride	breast cancer	24881749	-1
-Neuroleptic malignant syndrome induced by combination therapy with tetrabenazine and tiapride in a Japanese patient with Huntington's disease at the terminal stage of recurrent breast cancer.	tetrabenazine	Huntington's disease	24881749	-1
-Neuroleptic malignant syndrome induced by combination therapy with tetrabenazine and tiapride in a Japanese patient with Huntington's disease at the terminal stage of recurrent breast cancer.	tetrabenazine	Neuroleptic malignant syndrome	24881749	1
-Neuroleptic malignant syndrome induced by combination therapy with tetrabenazine and tiapride in a Japanese patient with Huntington's disease at the terminal stage of recurrent breast cancer.	tetrabenazine	breast cancer	24881749	-1
-Rhabdomyolysis and brain ischemic stroke in a heroin-dependent male under methadone maintenance therapy.	heroin	ischemic stroke	19392810	-1
-Rhabdomyolysis and brain ischemic stroke in a heroin-dependent male under methadone maintenance therapy.	heroin	Rhabdomyolysis	19392810	1
-Rhabdomyolysis and brain ischemic stroke in a heroin-dependent male under methadone maintenance therapy.	methadone	ischemic stroke	19392810	-1
-The purpose of this study was to assess the use of galantamine, an acetylcholinesterase inhibitor and nicotinic receptor modulator, in the treatment of interfering behaviors in children with autism.	galantamine	autism	17069550	-1
-Alternating sinus rhythm and intermittent sinoatrial block induced by propranolol. Alternating sinus rhythm and intermittent sinoatrial (S-A) block	propranolol	sinoatrial block	6529939	1
-The biological properties of the optical isomers of propranolol and their effects on cardiac arrhythmias.	propranolol	cardiac arrhythmias	19108278	-1
-In the motor activity test measured with an Animex-activity meter neither of the K(+)-channel blockers affected morphine-induced hypoactivity, but both K(+)-channel blockers prevented morphine-induced secondary hyperactivity.	morphine	hyperactivity	10390729	1
-In the motor activity test measured with an Animex-activity meter neither of the K(+)-channel blockers affected morphine-induced hypoactivity, but both K(+)-channel blockers prevented morphine-induced secondary hyperactivity.	morphine	hypoactivity	10390729	-1
-In the motor activity test measured with an Animex-activity meter neither of the K(+)-channel blockers affected morphine-induced hypoactivity, but both K(+)-channel blockers prevented morphine-induced secondary hyperactivity.	morphine	hyperactivity	10390729	1
-In the motor activity test measured with an Animex-activity meter neither of the K(+)-channel blockers affected morphine-induced hypoactivity, but both K(+)-channel blockers prevented morphine-induced secondary hyperactivity.	morphine	hypoactivity	10390729	-1
-In the motor activity test measured with an Animex-activity meter neither of the K(+)-channel blockers affected morphine-induced hypoactivity, but both K(+)-channel blockers prevented morphine-induced secondary hyperactivity.	K(+)-channel	hyperactivity	10390729	-1
-In the motor activity test measured with an Animex-activity meter neither of the K(+)-channel blockers affected morphine-induced hypoactivity, but both K(+)-channel blockers prevented morphine-induced secondary hyperactivity.	K(+)-channel	hypoactivity	10390729	-1
-In the motor activity test measured with an Animex-activity meter neither of the K(+)-channel blockers affected morphine-induced hypoactivity, but both K(+)-channel blockers prevented morphine-induced secondary hyperactivity.	K(+)-channel	hyperactivity	10390729	-1
-In the motor activity test measured with an Animex-activity meter neither of the K(+)-channel blockers affected morphine-induced hypoactivity, but both K(+)-channel blockers prevented morphine-induced secondary hyperactivity.	K(+)-channel	hypoactivity	10390729	-1
-Here we had the opportunity to study a case of refractory MCL who had tumor regression two months after temsirolimus treatment, and a progression-free survival of 10 months.	temsirolimus	tumor	20828385	-1
-Here we had the opportunity to study a case of refractory MCL who had tumor regression two months after temsirolimus treatment, and a progression-free survival of 10 months.	temsirolimus	MCL	20828385	-1
-Moderate to high dose corticosteroid use is recognized as a major risk factor for SRC.	corticosteroid	SRC	22836123	-1
-However, a 38% remission rate has been recently reported in refractory MCL treated with temsirolimus, a mTOR inhibitor.	temsirolimus	MCL	20828385	-1
-CONCLUSIONS: Severe hypotension and bradycardia occur at similar prevalence in neurocritical care patients who receive dexmedetomidine or propofol.	propofol	hypotension	24717468	1
-CONCLUSIONS: Severe hypotension and bradycardia occur at similar prevalence in neurocritical care patients who receive dexmedetomidine or propofol.	dexmedetomidine	bradycardia	24717468	1