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"""
cbio.py – cBioPortal REST helper (no API-key required for public portal).
Returns variant summary rows for a gene / profile.
"""
from functools import lru_cache
import httpx, asyncio
_BASE = "https://www.cbioportal.org/api/molecular-profiles/{profile}/genes/{gene}/mutations"
_HEADERS = {"Accept": "application/json"}
@lru_cache(maxsize=256)
async def fetch_cbio(
gene: str,
profile: str = "brca_tcga_pan_can_atlas_2018_mutations",
) -> list[dict]:
if not gene:
return []
url = _BASE.format(profile=profile, gene=gene)
params = {"projection": "SUMMARY"}
async with httpx.AsyncClient(timeout=10, headers=_HEADERS) as c:
r = await c.get(url, params=params)
if r.status_code >= 400:
return [] # swallow 4xx/5xx → empty list
return r.json()
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