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---
title: Lu-177 Dosimetry Tool
emoji: ⚛️
colorFrom: indigo
colorTo: blue
sdk: gradio
sdk_version: "3.47.1"
app_file: app.py
pinned: false
---
# Lu-177 Dosimetry Tool (Two-Time-Point Fitting)
This open-source web application calculates **Time-Integrated Activity (TIA)** based on **two post-treatment SPECT/CT time points** using a **mono-exponential washout model**.
## 👨⚕️ Purpose
The tool is designed for simplified, patient-specific dosimetry of **Lutetium-177–PSMA therapy** in individuals diagnosed with **metastatic castration-resistant prostate cancer (mCRPC)**. Its goal is to enable reliable dose estimation without complex imaging protocols.
## 📈 How It Works
Users provide:
- Two SPECT imaging time points (in hours)
- Corresponding activity measurements (in MBq)
The tool automatically:
- Fits a mono-exponential time–activity curve
- Calculates:
- Washout rate (_k_)
- Initial activity (_A₀_)
- Time-Integrated Activity (_TIA = A₀ / k_)
- Displays results instantly
## 🧠 Model Used
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