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65a9db96f20341fac5cbb0ce49a1dddd53bc0d487bd4ecad7cc54aad5f1a835e.png
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complex
|
<table><tr><td></td><td colspan="3">Mean (SD)</td><td><i>P</i> value</td></tr><tr><td></td><td>1st trimester</td><td>2nd trimester</td><td>3rd trimester</td><td></td></tr><tr><td>Completion time (minutes)</td><td>21.8 (7.5)</td><td>19.2 (6.8)</td><td>16.3 (5.1)</td><td>< 0.0001</td></tr><tr><td>Reported meals (N)</td><td>5.1 (0.9)</td><td>4.8 (1.1)</td><td>5.0 (1.2)</td><td>0.13</td></tr><tr><td>Reported items (N)</td><td>20.5 (4.0)</td><td>20.3 (4.1)</td><td>19.4 (4.0)</td><td>0.025</td></tr></table>
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<table><tr><td></td><td colspan="3">Mean (SD)</td><td>P value</td></tr><tr><td></td><td>1st trimester</td><td>2nd trimester</td><td>3rd trimester</td><td></td></tr><tr><td>Completion time (minutes)</td><td>21.8 (7.5)</td><td>19.2 (6.8)</td><td>16.3 (5.1)</td><td>< 0.0001</td></tr><tr><td>Reported meals (N)</td><td>5.1 (0.9)</td><td>4.8 (1.1)</td><td>5.0 (1.2)</td><td>0.13</td></tr><tr><td>Repor</td><td>20.5 (</td><td>20.</td><td>19.</td><td>0.0</td></tr></table>
|
<table><tr><td>ted items (N)</td><td>4.0)</td><td>3 (4.1)</td><td>4 (4.0)</td><td>25</td></tr></table>
|
eda30bec147b8384215b0cb4527ae995f1ddefa464c794e2b0446416584e5ab6.png
|
complex
|
<table><tr><td rowspan="2">Complications</td><td colspan="2">Group 1</td><td colspan="2">Group 2</td></tr><tr><td>To adult</td><td>To pediatrics</td><td><i>En-bloc</i></td><td>Single</td></tr><tr><td>Renal vein thrombosis</td><td>—</td><td>1 (early nephrectomy)</td><td>—</td><td>2 (graft loss)</td></tr><tr><td>Renal arterial thrombosis</td><td>1 (graft loss)</td><td>—</td><td>—</td><td>—</td></tr><tr><td>Significant lymphocele</td><td>1 (percutaneous drainage)</td><td>—</td><td>1 (percutaneous drainage)</td><td>1</td></tr><tr><td>Ureteral fistula</td><td>1 (surgical repair)</td><td>—</td><td>—</td><td>1 (surgical repair)</td></tr><tr><td>Ureteral stenosis</td><td>1 (surgical repair)</td><td>—</td><td>—</td><td>1 (surgical repair)</td></tr></table>
|
<table><tr><td rowspan="2">Complications</td><td colspan="2">Group 1</td><td colspan="2">Group 2</td></tr><tr><td>To adult</td><td>To pediatrics</td><td>En-bloc</td><td>Single</td></tr><tr><td>Renal vein thrombosis</td><td>β</td><td>1 (early nephrectomy)</td><td>β</td><td>2 (graft loss)</td></tr><tr><td>Renal arterial thrombosis</td><td>1 (graft loss)</td><td>β</td><td>β</td><td>β</td></tr></table>
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<table><tr><td>Significant lymphocele</td><td>1 (percutaneous drainage)</td><td>β</td><td>1 (percutaneous drainage)</td><td>1</td></tr><tr><td>Ureteral fistula</td><td>1 (surgical repair)</td><td>β</td><td>β</td><td>1 (surgical repair)</td></tr><tr><td>Ureteral stenosis</td><td>1 (surgical repair)</td><td>β</td><td>β</td><td>1 (surgical repair)</td></tr></table>
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558cef7f8cbb64547304d46decd7f1ab1fdd6238399d3359872789d16e4ccc02.png
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simple
|
<table><tr><td></td><td>n of cases</td><td>IPAT</td><td>PSP</td><td>IPAT & PSP</td></tr><tr><td>CF and RP/CP</td><td>48</td><td>14 (29.2)</td><td>11 (22.9)</td><td>19 (39.6)</td></tr><tr><td>CF without pancreatitis</td><td>35</td><td>2 (5.7)</td><td>3 (8.5)</td><td>4 (11.4)</td></tr><tr><td>healthy subjects</td><td>80</td><td>3 (3.8)</td><td>8 (10)</td><td>11 (13.7)</td></tr><tr><td>Chi square and (p)</td><td></td><td>20.4 (<i>p</i> < 0.001)</td><td>4.39 (<i>p</i> = 0.11)</td><td>14.5 (<i>p</i> < 0.001)</td></tr></table>
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<table><tr><td></td><td>n of cases</td><td>IPAT</td><td>PSP</td><td>IPAT & PSP</td></tr><tr><td>CF and RP/CP</td><td>48</td><td>14 (29.2)</td><td>11 (22.9)</td><td>19 (39.6)</td></tr></table>
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<table><tr><td>CF without pancreatitis</td><td>35</td><td>2 (5.7)</td><td>3 (8.5)</td><td>4 (11.4)</td></tr><tr><td>healthy subjects</td><td>80</td><td>3 (3.8)</td><td>8 (10)</td><td>11 (13.7)</td></tr><tr><td>Chi square and (p)</td><td></td><td>20.4 (p < 0.001)</td><td>4.39 (p = 0.11)</td><td>14.5 (p < 0.001)</td></tr></table>
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6a33c34ca0c50d1a11c80976ca9821c9565e940703c5d82b19e32d7b76f4dad7.png
|
simple
|
<table><tr><td>Gene</td><td>F/R</td><td>Primer sequence</td><td>Position</td><td>Tm</td></tr><tr><td>PEPT1</td><td>Forward</td><td>CCCTGAAGTGAAGGTGTTTGAAGATA</td><td>1772–1797</td><td>60.6</td></tr><tr><td>NM_005073</td><td>Reverse</td><td>GAATTGGCCCCTGACATGAA</td><td>2168–2188</td><td>59.3</td></tr><tr><td>PEPT2</td><td>Forward</td><td>CTACCACAATATGCCCTGGTTACA</td><td>1894–1917</td><td>58.8</td></tr><tr><td>NM_001145998</td><td>Reverse</td><td>GCCACTGAACTGTGCCACAA</td><td>2045–2064</td><td>59.3</td></tr><tr><td>ALAS1</td><td>Forward</td><td>GGATTCGAAACAGCCGAGTG</td><td>1371–1390</td><td>59.3</td></tr><tr><td>NM 000688</td><td>Reverse</td><td>GAAGGTGATTGCTCCAAACTCAT</td><td>1542–1564</td><td>58.3</td></tr><tr><td>ALAD</td><td>Forward</td><td>CCTCGGTTCCAACCAACTGAT</td><td>157–177</td><td>59.8</td></tr><tr><td>NM_000031</td><td>Reverse</td><td>GATAGGCTGTATGTCATCAGGAACA</td><td>319–343</td><td>58.2</td></tr><tr><td>HMBS</td><td>Forward</td><td>CAAGGACCAGGACATCTTGGAT</td><td>835–856</td><td>58.9</td></tr><tr><td>NM_000190</td><td>Reverse</td><td>CCAGACTCCTCCAGTCAGGTACA</td><td>984–1006</td><td>59.2</td></tr><tr><td>UROS</td><td>Forward</td><td>TCAGCACTGCCTCTTCTATTTCC</td><td>668–691</td><td>58.7</td></tr><tr><td>NM_000375</td><td>Reverse</td><td>CTGGGTGTGCAACTGTCTGATAC</td><td>761–789</td><td>58.3</td></tr><tr><td>UROD</td><td>Forward</td><td>CGGGAGTGTGTGGGGAA</td><td>982–998</td><td>57.2</td></tr><tr><td>NM_000374</td><td>Reverse</td><td>AAGCAGACGTGAGTGTTTATGCA</td><td>1178–1200</td><td>58.6</td></tr><tr><td>ABCB6</td><td>Forward</td><td>CAGAAGGGCCGTATTGAGTTTG</td><td>2033–2054</td><td>59.6</td></tr><tr><td>NM_005689</td><td>Reverse</td><td>ATTGTCGGCGATGGTGTCA</td><td>2308–2326</td><td>59.5</td></tr><tr><td>CPOX</td><td>Forward</td><td>GGCGGAGATGTTGCCTAAGAC</td><td>401–421</td><td>59.7</td></tr><tr><td>NM_000097</td><td>Reverse</td><td>AATGCTCACCCCAGCCTTTT</td><td>709–728</td><td>59.5</td></tr><tr><td>PPOX</td><td>Forward</td><td>CAGGAGTCCTGGGAATCGTGTA</td><td>1251–1272</td><td>59.9</td></tr><tr><td>NM_000309</td><td>Reverse</td><td>TGCCTAGCTGACTCTAGTTTTTGC</td><td>1509–1533</td><td>58.1</td></tr><tr><td>FECH</td><td>Forward</td><td>GGAAATCCATTGTTCTCTAAGGC</td><td>1252–1274</td><td>57.0</td></tr><tr><td>NM_001012515</td><td>Reverse</td><td>CTAAATAACACCCTCTCCACATCG</td><td>1462–1485</td><td>57.8</td></tr><tr><td>ABCG2</td><td>Forward</td><td>CTAAGCAGGGACGAACAATCATC</td><td>1188–1210</td><td>58.8</td></tr><tr><td>NM_004827</td><td>Reverse</td><td>TCCTGCTTGGAAGGCTCTATG</td><td>1447–1467</td><td>58.2</td></tr><tr><td>HIF-1alpha</td><td>Forward</td><td>GGCGCGAACGACAAGAA</td><td>420–436</td><td>58.0</td></tr><tr><td>NM 001530</td><td>Reverse</td><td>CAAAACCATCCAAGGCTTTCA</td><td>682–702</td><td>58.7</td></tr><tr><td>HO-1</td><td>Forward</td><td>GCTCAAAAAGATTGCCCAGAA</td><td>518–538</td><td>58.1</td></tr><tr><td>NM_002133</td><td>Reverse</td><td>TCACATGGCATAAAGCCCTACA</td><td>926–947</td><td>59.1</td></tr></table>
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<table><tr><td>Gene</td><td>F/R</td><td>Primer sequence</td><td>Position</td><td>Tm</td></tr><tr><td>PEPT1</td><td>Forward</td><td>CCCTGAAGTGAAGGTGTTTGAAGATA</td><td>1772β1797</td><td>60.6</td></tr><tr><td>NM_005073</td><td>Reverse</td><td>GAATTGGCCCCTGACATGAA</td><td>2168β2188</td><td>59.3</td></tr><tr><td>PEPT2</td><td>Forward</td><td>CTACCACAATATGCCCTGGTTACA</td><td>1894β1917</td><td>58.8</td></tr><tr><td>NM_001145998</td><td>Reverse</td><td>GCCACTGAACTGTGCCACAA</td><td>2045β2064</td><td>59.3</td></tr><tr><td>ALAS1</td><td>Forward</td><td>GGATTCGAAACAGCCGAGTG</td><td>1371β1390</td><td>59.3</td></tr><tr><td>NM 000688</td><td>Reverse</td><td>GAAGGTGATTGCTCCAAACTCAT</td><td>1542β1564</td><td>58.3</td></tr><tr><td>ALAD</td><td>Forward</td><td>CCTCGGTTCCAACCAACTGAT</td><td>157β177</td><td>59.8</td></tr><tr><td>NM_000031</td><td>Reverse</td><td>GATAGGCTGTATGTCATCAGGAACA</td><td>319β343</td><td>58.2</td></tr><tr><td>HMBS</td><td>Forward</td><td>CAAGGACCAGGACATCTTGGAT</td><td>835β856</td><td>58.9</td></tr><tr><td>NM_000190</td><td>Reverse</td><td>CCAGACTCCTCCAGTCAGGTACA</td><td>984β1006</td><td>59.2</td></tr><tr><td>UROS</td><td>Forward</td><td>TCAGCACTGCCTCTTCTATTTCC</td><td>668β691</td><td>58.7</td></tr><tr><td>NM_000375</td><td>Reverse</td><td>CTGGGTGTGCAACTGTCTGATAC</td><td>761β789</td><td>58.3</td></tr><tr><td>UROD</td><td>Forward</td><td>CGGGAGTGTGTGGGGAA</td><td>982β998</td><td>57.2</td></tr><tr><td>NM_000374</td><td>Reverse</td><td>AAGCAGACGTGAGTGTTTATGCA</td><td>1178β1200</td><td>58.6</td></tr><tr><td>ABCB6</td><td>Forward</td><td>CAGAAGGGCCGTATTGAGTTTG</td><td>2033β2054</td><td>59.6</td></tr><tr><td>NM_005689</td><td>Reverse</td><td>ATTGTCGGCGATGGTGTCA</td><td>2308β2326</td><td>59.5</td></tr><tr><td>CPOX</td><td>Forward</td><td>GGCGGAGATGTTGCCTAAGAC</td><td>401β421</td><td>59.7</td></tr><tr><td>NM_000097</td><td>Reverse</td><td>AATGCTCACCCCAGCCTTTT</td><td>709β728</td><td>59.5</td></tr><tr><td>PPOX</td><td>Forward</td><td>CAGGAGTCCTGGGAATCGTGTA</td><td>1251β1272</td><td>59.9</td></tr><tr><td>NM_000309</td><td>Reverse</td><td>TGCCTAGCTGACTCTAGTTTTTGC</td><td>1509β1533</td><td>58.1</td></tr><tr><td>FECH</td><td>Forward</td><td>GGAAATCCATTGTTCTCTAAGGC</td><td>1252β1274</td><td>57.0</td></tr></table>
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<table><tr><td>Gene</td><td>F/R</td><td>Primer sequence</td><td>Position</td><td>Tm</td></tr><tr><td>NM_001012515</td><td>Reverse</td><td>CTAAATAACACCCTCTCCACATCG</td><td>1462β1485</td><td>57.8</td></tr><tr><td>ABCG2</td><td>Forward</td><td>CTAAGCAGGGACGAACAATCATC</td><td>1188β1210</td><td>58.8</td></tr><tr><td>NM_004827</td><td>Reverse</td><td>TCCTGCTTGGAAGGCTCTATG</td><td>1447β1467</td><td>58.2</td></tr><tr><td>HIF-1alpha</td><td>Forward</td><td>GGCGCGAACGACAAGAA</td><td>420β436</td><td>58.0</td></tr><tr><td>NM 001530</td><td>Reverse</td><td>CAAAACCATCCAAGGCTTTCA</td><td>682β702</td><td>58.7</td></tr><tr><td>HO-1</td><td>Forward</td><td>GCTCAAAAAGATTGCCCAGAA</td><td>518β538</td><td>58.1</td></tr><tr><td>NM_002133</td><td>Reverse</td><td>TCACATGGCATAAAGCCCTACA</td><td>926β947</td><td>59.1</td></tr></table>
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cc110b00e92f29f012284b5756167319ce2118f44ec1d6cdaa820b6fcdc0c107.png
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simple
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<table><tr><td></td><td>LFD</td><td>LFD+NDEA</td><td>HFD</td><td>HFD+NDEA</td><td>F-Ratio</td><td>P-Value</td></tr><tr><td>AβPP</td><td>4.392 ± 0.423</td><td>3.966 ± 0.458</td><td>3.026* ± 0.215</td><td>3.228 ± 0.299</td><td>3.099</td><td>0.039</td></tr><tr><td>Tau</td><td>3.380 ± 0.272</td><td>2.689 ± 0.255</td><td>3.310 ± 0.270</td><td>1.938*** ± 0.209</td><td>7.023</td><td>0.001</td></tr><tr><td>ChAT</td><td>0.170 ± 0.016</td><td>0.147 ± 0.026</td><td>0.164 ± 0.014</td><td>0.115<sup>§ </sup>± 0.007</td><td></td><td>0.001</td></tr><tr><td>AChE</td><td>0.824 ± 0.081</td><td>1.080 ± 0.137</td><td>0.747 ± 0.099</td><td>0.795 ± 0.048</td><td></td><td></td></tr><tr><td>IL-1β</td><td>0.047 ± 0.004</td><td>0.047 ± 0.010</td><td>0.052 ± 0.005</td><td>0.023* ± 0.003</td><td>4.627</td><td>0.008</td></tr><tr><td>IL6</td><td>0.052 ± 0.006</td><td>0.045 ± 0.006</td><td>0.050 ± 0.005</td><td>0.034 ± 0.005</td><td></td><td></td></tr><tr><td>TNF-α</td><td>0.022 ± 0.002</td><td>0.035 ± 0.005</td><td>0.034 ± 0.005</td><td>0.036 ± 0.004</td><td></td><td></td></tr></table>
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<table><tr><td></td><td>LFD</td><td>LFD+NDEA</td><td>HFD</td><td>HFD+NDEA</td><td>F-Ratio</td><td>P-Value</td></tr><tr><td>AΞ²PP</td><td>4.392 Β± 0.423</td><td>3.966 Β± 0.458</td><td>3.026* Β± 0.215</td><td>3.228 Β± 0.299</td><td>3.099</td><td>0.039</td></tr><tr><td>Tau</td><td>3.380 Β± 0.272</td><td>2.689 Β± 0.255</td><td>3.310 Β± 0.270</td><td>1.938*** Β± 0.209</td><td>7.023</td><td>0.001</td></tr><tr><td>ChAT</td><td>0.170 Β± 0.016</td><td>0.147 Β± 0.026</td><td>0.164 Β± 0.014</td><td>0.115Β§ Β± 0.007</td><td></td><td>0.001</td></tr><tr><td>AChE</td><td>0.824 Β± 0.081</td><td>1.080 Β± 0.137</td><td>0.747 Β± 0.099</td><td>0.795 Β± 0.048</td><td></td><td></td></tr><tr><td>IL-1Ξ²</td><td>0.047 Β± 0.004</td><td>0.047 Β± 0.010</td><td>0.052 Β± 0.005</td><td>0.023* Β± 0.003</td><td>4.627</td><td>0.008</td></tr></table>
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<table><tr><td></td><td>LFD</td><td>LFD+NDEA</td><td>HFD</td><td>HFD+NDEA</td><td>F-Ratio</td><td>P-Value</td></tr><tr><td>IL6</td><td>0.052 Β± 0.006</td><td>0.045 Β± 0.006</td><td>0.050 Β± 0.005</td><td>0.034 Β± 0.005</td><td></td><td></td></tr><tr><td>TNF-Ξ±</td><td>0.022 Β± 0.002</td><td>0.035 Β± 0.005</td><td>0.034 Β± 0.005</td><td>0.036 Β± 0.004</td><td></td><td></td></tr></table>
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b8a9a2b2c4bb3514a6d944043ebce68d58ca1a63f27d87395cf72d679b249b63.png
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simple
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<table><tr><td></td><td>Pain score ribs</td><td>Pain score iliac crest</td></tr><tr><td>Hospital admission, oral analgesics</td><td>5</td><td>Not applicable</td></tr><tr><td>Pre-operative, with epidural catheter</td><td>3-6</td><td>Not applicable</td></tr><tr><td>Post-operative day 3, with epidural catheter</td><td>1-2</td><td>4-5</td></tr><tr><td>Discharge home, oral analgesics</td><td>1-2</td><td>3-5</td></tr></table>
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<table><tr><td></td><td>Pain score ribs</td><td>Pain score iliac crest</td></tr><tr><td>Hospital admission, oral analgesics</td><td>5</td><td>Not applicable</td></tr></table>
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<table><tr><td></td><td>Pain score ribs</td><td>Pain score iliac crest</td></tr><tr><td>Pre-operative, with epidural catheter</td><td>3-6</td><td>Not applicable</td></tr><tr><td>Post-operative day 3, with epidural catheter</td><td>1-2</td><td>4-5</td></tr><tr><td>Discharge home, oral analgesics</td><td>1-2</td><td>3-5</td></tr></table>
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6fef4dad16957411564704d941462ecda33a0ba75e74072904aff01e3bdaf310.png
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complex
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<table><tr><td>Data set</td><td><i>n</i></td><td>MI Re</td><td>KNNI Re</td><td>SVRI Re</td><td>ELMI {Re, Ri}</td></tr><tr><td rowspan="3">Breast</td><td>3</td><td>4.79%</td><td>4.86%</td><td>4.71%</td><td>{4.52%, 3.18%}</td></tr><tr><td>5</td><td>8.23%</td><td>8.38%</td><td>5.96%</td><td>{4.90%, 3.31%}</td></tr><tr><td>7</td><td>14.75%</td><td>14.29%</td><td>12.45%</td><td>{10.42%, 5.59%}</td></tr><tr><td rowspan="3">Iris</td><td>1</td><td>23.96%</td><td>5.65%</td><td>5.13%</td><td>{4.77%, 2.09%}</td></tr><tr><td>2</td><td>43.67%</td><td>13.72%</td><td>8.07%</td><td>{8.12%, 6.52%}</td></tr><tr><td>3</td><td>65.49%</td><td>21.06%</td><td>12.89%</td><td>{12.92%, 9.23%}</td></tr><tr><td rowspan="3">Seeds</td><td>2</td><td>21.05%</td><td>12.38%</td><td>9.26%</td><td>{9.47%, 4.13%}</td></tr><tr><td>4</td><td>28.39%</td><td>13.62%</td><td>10.83%</td><td>{9.65%, 4.86%}</td></tr><tr><td>6</td><td>40.93%</td><td>27.34%</td><td>18.37%</td><td>{17.02%, 12.53%}</td></tr><tr><td rowspan="3">Wine</td><td>3</td><td>31.26%</td><td>27.18%</td><td>26.51%</td><td>{26.17%, 1.64%}</td></tr><tr><td>6</td><td>33.98%</td><td>27.93%</td><td>27.14%</td><td>{26.83%, 1.58%}</td></tr><tr><td>9</td><td>38.02%</td><td>30.36%</td><td>28.33%</td><td>{27.25%, 3.67%}</td></tr><tr><td rowspan="3">Segment</td><td>3</td><td>12.71%</td><td>10.46%</td><td>9.52%</td><td>{6.89%, 1.37%}</td></tr><tr><td>7</td><td>15.83%</td><td>12.38%</td><td>10.07%</td><td>{7.16%, 3.25%}</td></tr><tr><td>11</td><td>20.23%</td><td>17.35%</td><td>12.06%</td><td>{10.35%, 3.76%}</td></tr><tr><td rowspan="3">Satimag</td><td>7</td><td>41.28%</td><td>40.70%</td><td>33.62%</td><td>{29.63%, 12.81%}</td></tr><tr><td>9</td><td>44.75%</td><td>42.36%</td><td>36.59%</td><td>{30.87%, 18.24%}</td></tr><tr><td>19</td><td>52.96%</td><td>51.22%</td><td>47.67%</td><td>{36.92%, 22.75%}</td></tr></table>
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<table><tr><td>Data set</td><td>n</td><td>MI Re</td><td>KNNI Re</td><td>SVRI Re</td><td>ELMI {Re, Ri}</td></tr><tr><td rowspan="3">Breast</td><td>3</td><td>4.79%</td><td>4.86%</td><td>4.71%</td><td>{4.52%, 3.18%}</td></tr><tr><td>5</td><td>8.23%</td><td>8.38%</td><td>5.96%</td><td>{4.90%, 3.31%}</td></tr><tr><td>7</td><td>14.75%</td><td>14.29%</td><td>12.45%</td><td>{10.42%, 5.59%}</td></tr><tr><td rowspan="2">Iris</td><td>1</td><td>23.96%</td><td>5.65%</td><td>5.13%</td><td>{4.77%, 2.09%}</td></tr><tr><td>2</td><td>43.67%</td><td>13.72%</td><td>8.07%</td><td>{8.12%, 6.52%}</td></tr></table>
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<table><tr><td>Data set</td><td>n</td><td>MI Re</td><td>KNNI Re</td><td>SVRI Re</td><td>ELMI {Re, Ri}</td></tr><tr><td>Iris</td><td>3</td><td>65.49%</td><td>21.06%</td><td>12.89%</td><td>{12.92%, 9.23%}</td></tr><tr><td rowspan="3">Seeds</td><td>2</td><td>21.05%</td><td>12.38%</td><td>9.26%</td><td>{9.47%, 4.13%}</td></tr><tr><td>4</td><td>28.39%</td><td>13.62%</td><td>10.83%</td><td>{9.65%, 4.86%}</td></tr><tr><td>6</td><td>40.93%</td><td>27.34%</td><td>18.37%</td><td>{17.02%, 12.53%}</td></tr><tr><td rowspan="3">Wine</td><td>3</td><td>31.26%</td><td>27.18%</td><td>26.51%</td><td>{26.17%, 1.64%}</td></tr><tr><td>6</td><td>33.98%</td><td>27.93%</td><td>27.14%</td><td>{26.83%, 1.58%}</td></tr><tr><td>9</td><td>38.02%</td><td>30.36%</td><td>28.33%</td><td>{27.25%, 3.67%}</td></tr><tr><td rowspan="3">Segment</td><td>3</td><td>12.71%</td><td>10.46%</td><td>9.52%</td><td>{6.89%, 1.37%}</td></tr><tr><td>7</td><td>15.83%</td><td>12.38%</td><td>10.07%</td><td>{7.16%, 3.25%}</td></tr><tr><td>11</td><td>20.23%</td><td>17.35%</td><td>12.06%</td><td>{10.35%, 3.76%}</td></tr><tr><td rowspan="3">Satimag</td><td>7</td><td>41.28%</td><td>40.70%</td><td>33.62%</td><td>{29.63%, 12.81%}</td></tr><tr><td>9</td><td>44.75%</td><td>42.36%</td><td>36.59%</td><td>{30.87%, 18.24%}</td></tr><tr><td>19</td><td>52.96%</td><td>51.22%</td><td>47.67%</td><td>{36.92%, 22.75%}</td></tr></table>
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635cc3ba334ce88f71af9f83abf961b4d623bcfdf423de17efd679ea28cdde71.png
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simple
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<table><tr><td> </td><td>Control group</td><td>LNM group</td><td><i>P</i></td></tr><tr><td>Initial visual ID of RLN (%)</td><td>179/185 (96.8%)</td><td>152/156 (97.4%)</td><td>0.76<sup>a</sup></td></tr><tr><td>Final ID of RLN (%)</td><td>179/185 (96.8%)</td><td>156/156 (100%)</td><td>0.03<sup>a</sup></td></tr><tr><td><i>P</i></td><td>—</td><td>0.12<sup>a</sup></td><td>—</td></tr><tr><td>Initial visual ID of EBSLN (%)</td><td>73/185 (39.5%)</td><td>67/156 (42.9%)</td><td>0.51</td></tr><tr><td>Final ID of EBSLN (%)</td><td>73/185 (39.5%)</td><td>118/156 (75.6%)</td><td><0.01</td></tr><tr><td><i>P</i></td><td>—</td><td><0.01</td><td>—</td></tr></table>
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<table><tr><td></td><td>Control group</td><td>LNM group</td><td>P</td></tr><tr><td>Initial visual ID of RLN (%)</td><td>179/185 (96.8%)</td><td>152/156 (97.4%)</td><td>0.76a</td></tr><tr><td>Final ID of RLN (%)</td><td>179/185 (96.8%)</td><td>156/156 (100%)</td><td>0.03a</td></tr></table>
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<table><tr><td></td><td>Control group</td><td>LNM group</td><td>P</td></tr><tr><td>P</td><td>β</td><td>0.12a</td><td>β</td></tr><tr><td>Initial visual ID of EBSLN (%)</td><td>73/185 (39.5%)</td><td>67/156 (42.9%)</td><td>0.51</td></tr><tr><td>Final ID of EBSLN (%)</td><td>73/185 (39.5%)</td><td>118/156 (75.6%)</td><td><0.01</td></tr><tr><td>P</td><td>β</td><td><0.01</td><td>β</td></tr></table>
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8d5d00736b66b9ff93c1427013f5e86057e07b7e842871b4b61bdffb22b32e2f.png
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simple
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<table><tr><td>Algorithm</td><td><i>precision</i></td><td><i>recall</i></td><td><i>f-measure</i></td></tr><tr><td>SHC[31,32]</td><td>0.4447</td><td>0.3430</td><td>0.3873</td></tr><tr><td>SC[13]</td><td>0.3612</td><td>0.3555</td><td>0.3584</td></tr><tr><td>MCL[12]</td><td>0.3569</td><td>0.3879</td><td>0.3717</td></tr><tr><td>Newman[8]</td><td>0.4665</td><td>0.4186</td><td>0.4413</td></tr><tr><td>RNSC[9]</td><td>0.4067</td><td>0.4696</td><td>0.4359</td></tr><tr><td>ISHC</td><td>0.6624</td><td>0.3620</td><td>0.4673</td></tr></table>
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<table><tr><td>Algorithm</td><td>precision</td><td>recall</td><td>f-measure</td></tr><tr><td>SHC[31,32]</td><td>0.4447</td><td>0.3430</td><td>0.3873</td></tr><tr><td>SC[13]</td><td>0.3612</td><td>0.3555</td><td>0.3584</td></tr><tr><td>MCL[12]</td><td>0.3569</td><td>0.3879</td><td>0.3717</td></tr><tr><td>Newman[8]</td><td>0.4665</td><td>0.4186</td><td>0.4413</td></tr><tr><td>RNSC[9]</td><td>0.4067</td><td>0.4696</td><td>0.4359</td></tr></table>
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<table><tr><td>ISHC</td><td>0.6624</td><td>0.3620</td><td>0.4673</td></tr></table>
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0f3babdfcf18c2eb8150db565fa749c992de97d407bc2d1786698557ec0acb42.png
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simple
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<table><tr><td>Class</td><td><i>T. urticae</i></td><td><i>P. ulmi</i></td><td><i>P. citri</i></td></tr><tr><td>A</td><td>18</td><td>10</td><td>7</td></tr><tr><td>B</td><td>6</td><td>4</td><td>4</td></tr><tr><td>C</td><td>78</td><td>28</td><td>26</td></tr><tr><td>D</td><td>2</td><td>2</td><td>2</td></tr><tr><td>E</td><td>2</td><td>2</td><td>2</td></tr><tr><td>F</td><td>6</td><td>6</td><td>6</td></tr><tr><td>G</td><td>23</td><td>12</td><td>8</td></tr><tr><td>H</td><td>22</td><td>18</td><td>12</td></tr><tr><td>Total</td><td>157</td><td>82</td><td>67</td></tr></table>
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<table><tr><td>Class</td></tr><tr><td>A</td></tr><tr><td>B</td></tr><tr><td>C</td></tr><tr><td>D</td></tr><tr><td>E</td></tr><tr><td>F</td></tr><tr><td>G</td></tr><tr><td>H</td></tr><tr><td>Total</td></tr></table>
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<table><tr><td>T. urticae</td><td>P. ulmi</td><td>P. citri</td></tr><tr><td>18</td><td>10</td><td>7</td></tr><tr><td>6</td><td>4</td><td>4</td></tr><tr><td>78</td><td>28</td><td>26</td></tr><tr><td>2</td><td>2</td><td>2</td></tr><tr><td>2</td><td>2</td><td>2</td></tr><tr><td>6</td><td>6</td><td>6</td></tr><tr><td>23</td><td>12</td><td>8</td></tr><tr><td>22</td><td>18</td><td>12</td></tr><tr><td>157</td><td>82</td><td>67</td></tr></table>
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b906d1bbfce03cfd533b507630f9b55b745f191a54830bde640b1e9c1bf81f0a.png
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complex
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<table><tr><td rowspan="2" colspan="2"> </td><td colspan="2">Vascularization ≤ 1 point</td></tr><tr><td>No</td><td>Yes</td></tr><tr><td rowspan="2">Target IOP not reached</td><td>No</td><td>39</td><td>3</td></tr><tr><td>Yes</td><td>10</td><td>5</td></tr><tr><td>Agreement</td><td>Kappa</td><td> </td><td>.31</td></tr></table>
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<table><tr><td colspan="2"></td><td colspan="2">Vascularization β€ 1 point</td></tr></table>
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<table><tr><td colspan="2"></td><td>No</td><td>Yes</td></tr><tr><td rowspan="2">Target IOP not reached</td><td>No</td><td>39</td><td>3</td></tr><tr><td>Yes</td><td>10</td><td>5</td></tr><tr><td>Agreement</td><td>Kappa</td><td></td><td>.31</td></tr></table>
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2e41f56acb9440f27298eaade0bc1d70ab2f12ac2b1f9d1928e6f6dcc58a7e40.png
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complex
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<table><tr><td>Dependent measure</td><td>Condition</td><td colspan="3">Descriptive statistics</td><td colspan="9">Inferential statistics</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td colspan="3">Group</td><td colspan="3">Condition</td><td colspan="3">Group × condition</td></tr><tr><td></td><td></td><td>ASD (<i>n</i> = 19)</td><td>Comparison (<i>n</i> = 20)</td><td>Total</td><td><i>F</i><sub>(1, 37)</sub></td><td><i>p</i></td><td><i>r</i></td><td><i>F</i><sub>(1, 37)</sub></td><td><i>p</i></td><td><i>r</i></td><td><i>F</i><sub>(1, 37)</sub></td><td><i>p</i></td><td><i>r</i></td></tr><tr><td rowspan="4">Proportion of time in target quadrant</td><td>Visible</td><td>0.91 (0.04)</td><td>0.89 (0.07)</td><td>0.90 (0.05)</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Hidden</td><td>0.79 (0.17)</td><td>0.85 (0.08)</td><td>0.82 (0.13)</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Total</td><td>0.85 (0.13)</td><td>0.87 (0.08)</td><td>0.86 (0.11)</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td></td><td></td><td>0.61</td><td>0.439</td><td>0.13</td><td>16.16</td><td><0.001</td><td>0.55</td><td>3.72</td><td>0.062</td><td>0.30</td></tr><tr><td rowspan="4">Latency to reach target (seconds)</td><td>Visible</td><td>66.12 (13.94)</td><td>60.24 (7.52)</td><td>63.10 (11.37)</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Hidden</td><td>87.33 (26.49)</td><td>68.15 (10.83)</td><td>77.50 (22.03)</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Total</td><td>76.73 (23.49)</td><td>64.20 (10.04)</td><td>70.30 (18.86)</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td></td><td></td><td>7.61</td><td>0.009</td><td>0.41</td><td>33.62</td><td><0.001</td><td>0.69</td><td>7.01</td><td>0.012</td><td>0.40</td></tr><tr><td rowspan="4">Proportion of successful trials</td><td>Visible</td><td>0.99 (0.06)</td><td>1.00 (0.00)</td><td>0.99 (0.04)</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Hidden</td><td>0.86 (0.19)</td><td>0.96 (0.09)</td><td>0.91 (0.16)</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Total</td><td>0.92 (0.15)</td><td>0.98 (0.06)</td><td>0.95 (0.12)</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td></td><td></td><td>5.59</td><td>0.023</td><td>0.36</td><td>12.41</td><td>0.001</td><td>0.50</td><td>3.84</td><td>0.058</td><td>0.31</td></tr><tr><td rowspan="4">Velocity (virtual units/second)</td><td>Visible</td><td>7.07 (1.05)</td><td>7.51 (0.70)</td><td>7.30 (0.90)</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Hidden</td><td>7.60 (1.00)</td><td>8.02 (0.68)</td><td>7.82 (0.87)</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Total</td><td>7.33 (1.05)</td><td>7.77 (0.73)</td><td>7.56 (0.92)</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td></td><td></td><td>2.80</td><td>0.103</td><td>0.27</td><td>27.17</td><td><0.001</td><td>0.65</td><td>0.01</td><td>0.92</td><td>0.02</td></tr><tr><td rowspan="4">Path length (virtual units)</td><td>Visible</td><td>443.65 (23.32)</td><td>438.72 (34.51)</td><td>441.12 (29.31)</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Hidden</td><td>634.33 (167.05)</td><td>537.28 (79.26)</td><td>584.56 (137.02)</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Total</td><td>538.99 (152.23)</td><td>488.00 (78.31)</td><td>512.84 (122.07)</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td></td><td></td><td>4.56</td><td>0.039</td><td>0.33</td><td>61.98</td><td><0.001</td><td>0.79</td><td>6.29</td><td>0.017</td><td>0.38</td></tr><tr><td rowspan="4">Cumulative distance to target (virtual units)</td><td>Visible</td><td>30989 (7933)</td><td>28349 (4186)</td><td>29635 (6353)</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Hidden</td><td>46373 (20316)</td><td>33307 (7673)</td><td>39672 (16392)</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Total</td><td>38681 (17093)</td><td>30828 (6597)</td><td>34654 (13343)</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td></td><td></td><td>7.16</td><td>0.011</td><td>0.40</td><td>19.61</td><td><0.001</td><td>0.59</td><td>5.15</td><td>0.029</td><td>0.35</td></tr></table>
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<table><tr><td>Dependent measure</td><td>Condition</td><td colspan="3">Descriptive statistics</td></tr><tr><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td>ASD (n = 19)</td><td>Comparison (n = 20)</td><td>Total</td></tr><tr><td rowspan="4">Proportion of time in target quadrant</td><td>Visible</td><td>0.91 (0.04)</td><td>0.89 (0.07)</td><td>0.90 (0.05)</td></tr><tr><td>Hidden</td><td>0.79 (0.17)</td><td>0.85 (0.08)</td><td>0.82 (0.13)</td></tr><tr><td>Total</td><td>0.85 (0.13)</td><td>0.87 (0.08)</td><td>0.86 (0.11)</td></tr><tr><td></td><td></td><td></td><td></td></tr><tr><td rowspan="4">Latency to reach target (seconds)</td><td>Visible</td><td>66.12 (13.94)</td><td>60.24 (7.52)</td><td>63.10 (11.37)</td></tr><tr><td>Hidden</td><td>87.33 (26.49)</td><td>68.15 (10.83)</td><td>77.50 (22.03)</td></tr><tr><td>Total</td><td>76.73 (23.49)</td><td>64.20 (10.04)</td><td>70.30 (18.86)</td></tr><tr><td></td><td></td><td></td><td></td></tr><tr><td rowspan="4">Proportion of successful trials</td><td>Visible</td><td>0.99 (0.06)</td><td>1.00 (0.00)</td><td>0.99 (0.04)</td></tr><tr><td>Hidden</td><td>0.86 (0.19)</td><td>0.96 (0.09)</td><td>0.91 (0.16)</td></tr><tr><td>Total</td><td>0.92 (0.15)</td><td>0.98 (0.06)</td><td>0.95 (0.12)</td></tr><tr><td></td><td></td><td></td><td></td></tr><tr><td rowspan="4">Velocity (virtual units/second)</td><td>Visible</td><td>7.07 (1.05)</td><td>7.51 (0.70)</td><td>7.30 (0.90)</td></tr><tr><td>Hidden</td><td>7.60 (1.00)</td><td>8.02 (0.68)</td><td>7.82 (0.87)</td></tr><tr><td>Total</td><td>7.33 (1.05)</td><td>7.77 (0.73)</td><td>7.56 (0.92)</td></tr><tr><td></td><td></td><td></td><td></td></tr><tr><td rowspan="4">Path length (virtual units)</td><td>Visible</td><td>443.65 (23.32)</td><td>438.72 (34.51)</td><td>441.12 (29.31)</td></tr><tr><td>Hidden</td><td>634.33 (167.05)</td><td>537.28 (79.26)</td><td>584.56 (137.02)</td></tr><tr><td>Total</td><td>538.99 (152.23)</td><td>488.00 (78.31)</td><td>512.84 (122.07)</td></tr><tr><td></td><td></td><td></td><td></td></tr><tr><td rowspan="4">Cumulative distance to target (virtual units)</td><td>Visible</td><td>30989 (7933)</td><td>28349 (4186)</td><td>29635 (6353)</td></tr><tr><td>Hidden</td><td>46373 (20316)</td><td>33307 (7673)</td><td>39672 (16392)</td></tr><tr><td>Total</td><td>38681 (17093)</td><td>30828 (6597)</td><td>34654 (13343)</td></tr><tr><td></td><td></td><td></td><td></td></tr></table>
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<table><tr><td colspan="9">Inferential statistics</td></tr><tr><td colspan="3">Group</td><td colspan="3">Condition</td><td colspan="3">Group Γ condition</td></tr><tr><td>F(1, 37)</td><td>p</td><td>r</td><td>F(1, 37)</td><td>p</td><td>r</td><td>F(1, 37)</td><td>p</td><td>r</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>0.61</td><td>0.439</td><td>0.13</td><td>16.16</td><td><0.001</td><td>0.55</td><td>3.72</td><td>0.062</td><td>0.30</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>7.61</td><td>0.009</td><td>0.41</td><td>33.62</td><td><0.001</td><td>0.69</td><td>7.01</td><td>0.012</td><td>0.40</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>5.59</td><td>0.023</td><td>0.36</td><td>12.41</td><td>0.001</td><td>0.50</td><td>3.84</td><td>0.058</td><td>0.31</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>2.80</td><td>0.103</td><td>0.27</td><td>27.17</td><td><0.001</td><td>0.65</td><td>0.01</td><td>0.92</td><td>0.02</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>4.56</td><td>0.039</td><td>0.33</td><td>61.98</td><td><0.001</td><td>0.79</td><td>6.29</td><td>0.017</td><td>0.38</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>7.16</td><td>0.011</td><td>0.40</td><td>19.61</td><td><0.001</td><td>0.59</td><td>5.15</td><td>0.029</td><td>0.35</td></tr></table>
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968858b34f78333ba9ee1d1116ec17588e4442cc924e22e0e066d81dacfd9b78.png
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complex
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<table><tr><td></td><td></td><td colspan="3">Temperature shift</td><td colspan="3">Blood feeding</td><td colspan="2">Temperature shift + Blood feeding</td></tr><tr><td></td><td></td><td>Microarray</td><td colspan="2">RT-qPCR</td><td>Microarray</td><td colspan="2">RT-qPCR</td><td colspan="2">RT-qPCR</td></tr><tr><td>Gene ID</td><td>Annotation</td><td>Fold change (replicate 1; replicate 2)</td><td>Fold change</td><td><i>p</i>-value</td><td>Fold change (replicate 1; replicate 2)</td><td>Fold change</td><td><i>p</i>-value</td><td>Fold change</td><td><i>p</i>-value</td></tr><tr><td>A1G_00295</td><td>cell surface antigen-like protein Sca10</td><td>ND</td><td>-1.67</td><td>0.0000</td><td>-2.33 (-2.39; -2.27)</td><td>-4.76</td><td>0.0000</td><td>-8.33</td><td>0.0000</td></tr><tr><td>A1G_00515</td><td>ADP,ATP carrier protein</td><td>ND</td><td>NS</td><td></td><td>-1.96 (-1.91; -2.02)</td><td>-2.17</td><td>0.0000</td><td>-2.13</td><td>0.0000</td></tr><tr><td>A1G_00520</td><td>glycerol-3-phosphate transporter</td><td>ND</td><td>NS</td><td></td><td>-1.73 (-1.62; -1.83)</td><td>-2.70</td><td>0.0000</td><td>-2.22</td><td>0.0000</td></tr><tr><td>A1G_00680</td><td>30S ribosomal protein S2</td><td>ND</td><td>1.41</td><td>0.0018</td><td>-2.46 (-2.62; -2.29)</td><td>-4.00</td><td>0.0000</td><td>-2.86</td><td>0.0000</td></tr><tr><td>A1G_00685</td><td>elongation factor Ts</td><td>ND</td><td>NS</td><td></td><td>-1.79 (-1.79; -1.78)</td><td>-2.94</td><td>0.0000</td><td>-2.70</td><td>0.0000</td></tr><tr><td>A1G_00810</td><td>type IV secretion system protein VirB3</td><td>ND</td><td>1.45</td><td>0.0016</td><td>-1.98 (-2.07; -1.89)</td><td>-2.78</td><td>0.0000</td><td>-1.92</td><td>0.0000</td></tr><tr><td>A1G_01445</td><td>cell surface antigen-like protein Sca8</td><td>ND</td><td>1.43</td><td>0.0080</td><td>-5.41 (-5.66; -5.15)</td><td>-12.5</td><td>0.0000</td><td>-8.33</td><td>0.0000</td></tr><tr><td>A1G_01495</td><td>ferredoxin</td><td>ND</td><td>NS</td><td></td><td>2.19 (2.30; 2.09)</td><td>1.36</td><td>0.0000</td><td>1.29</td><td>0.0012</td></tr><tr><td>A1G_01525</td><td>glutaredoxin 3</td><td>ND</td><td>-1,25</td><td>0.0019</td><td>2.68 (3.12; 2.23)</td><td>1.93</td><td>0.0000</td><td>1.54</td><td>0.0000</td></tr><tr><td>A1G_02205</td><td>virB9 protein</td><td>ND</td><td>-1.27</td><td>0.0045</td><td>2.38 (2.42; 2.35)</td><td>1.56</td><td>0.0000</td><td>NS</td><td></td></tr><tr><td>A1G_02230</td><td>virB10 protein</td><td>ND</td><td>NS</td><td></td><td>1.72 (1.69; 1.76)</td><td>1.55</td><td>0.0000</td><td>1.81</td><td>0.0000</td></tr><tr><td>A1G_02235</td><td>type IV secretion system ATPase VirB11</td><td>ND</td><td>-1.35</td><td>0.0002</td><td>1.68 (1.70; 1.66)</td><td>2.00</td><td>0.0000</td><td>1.49</td><td>0.0000</td></tr><tr><td>A1G_02240</td><td>type IV secretion system component VirD4</td><td>ND</td><td>-1.19</td><td>0.0196</td><td>1.83 (1.72; 1.94)</td><td>1.64</td><td>0.0000</td><td>1.38</td><td>0.0000</td></tr><tr><td>A1G_02555</td><td>thioredoxin peroxidase 1</td><td>ND</td><td>NS</td><td></td><td>1.67 (1.59; 1.75)</td><td>1.84</td><td>0.0000</td><td>2.06</td><td>0.0000</td></tr><tr><td>A1G_02680</td><td>16S rRNA-processing protein RimM</td><td>ND</td><td>NS</td><td></td><td>-2.06 (-2.18; -1.93)</td><td>-2.78</td><td>0.0000</td><td>-2.33</td><td>0.0000</td></tr><tr><td>A1G_02785</td><td>site-specific tyrosine recombinase XerD</td><td>1.53 (1.53; 1.53)</td><td>1.86</td><td>0.0000</td><td>-2.69 (-2.52; -2.87)</td><td>-4.35</td><td>0.0000</td><td>-2.27</td><td>0.0000</td></tr><tr><td>A1G_03790</td><td>cell surface antigen</td><td>-1.79 (-1.99; -1.60)</td><td>-1.96</td><td>0.0000</td><td>ND</td><td>1.40</td><td>0.0002</td><td>0.72</td><td>0.0000</td></tr><tr><td>A1G_05315</td><td>chaperonin GroEL</td><td>ND</td><td>1.46</td><td>0.0006</td><td>-1.71 (-1.53; -1.88)</td><td>-2.27</td><td>0.0000</td><td>-1.54</td><td>0.0000</td></tr><tr><td>A1G_05630</td><td>cold shock-like protein</td><td>1.92 (1.98; 1.87)</td><td>1.36</td><td>0.0063</td><td>ND</td><td>-1.96</td><td>0.0000</td><td>-1.43</td><td>0.0002</td></tr><tr><td>A1G_05960</td><td>bicyclomycin resistance protein</td><td>1.57 (1.60; 1.53)</td><td>1.82</td><td>0.0000</td><td>ND</td><td>-5.88</td><td>0.0000</td><td>-3.33</td><td>0.0000</td></tr><tr><td>A1G_05625</td><td>ATP-dependent RNA helicase RhlE</td><td>ND</td><td>NS</td><td></td><td>-2.87 (-3.13; -2.62)</td><td>-4.76</td><td>0.0000</td><td>-3.85</td><td>0.0000</td></tr><tr><td>A1G_06265</td><td>ADP,ATP carrier protein</td><td>ND</td><td>1.47</td><td>0.0005</td><td>-2.30 (-2.20; -2.41)</td><td>-4.17</td><td>0.0000</td><td>-2.78</td><td>0.0000</td></tr><tr><td>A1G_06705</td><td>NADH dehydrogenase subunit J</td><td>ND</td><td>1.46</td><td>0.0018</td><td>-2.02 (-2.11; -1.93)</td><td>-4.17</td><td>0.0000</td><td>-2.86</td><td>0.0000</td></tr><tr><td>A1G_06710</td><td>NADH dehydrogenase subunit K</td><td>ND</td><td>NS</td><td></td><td>-4.08 (-4.59; -3.56)</td><td>-12.5</td><td>0.0000</td><td>-10.00</td><td>0.0000</td></tr><tr><td>A1G_06715</td><td>NADH dehydrogenase subunit L</td><td>ND</td><td>1.46</td><td>0.0124</td><td>-1.75 (-1.97; -1.54)</td><td>-7.14</td><td>0.0000</td><td>-5.00</td><td>0.0000</td></tr><tr><td>A1G_07470</td><td>DNA mismatch repair protein</td><td>-1.62 (-1.69; -1.54)</td><td>-1.22</td><td>0.0481</td><td>ND</td><td>1.32</td><td>0.0001</td><td>NS</td><td></td></tr><tr><td>A1G_00825</td><td>hypothetical protein A1G_00825</td><td>ND</td><td>1.62</td><td>0.0012</td><td>-1.68 (-1.77; -1.59)</td><td>-3.03</td><td>0.0000</td><td>-1.85</td><td>0.0000</td></tr><tr><td>A1G_02840</td><td>hypothetical protein A1G_02840</td><td>ND</td><td>NS</td><td></td><td>-3.03 (-3.30; -2.77)</td><td>-6.67</td><td>0.0000</td><td>-7.14</td><td>0.0000</td></tr><tr><td>A1G_06350</td><td>hypothetical protein A1G_06350</td><td>ND</td><td>NS</td><td></td><td>3.57 (4.12; 3.01)</td><td>1.76</td><td>0.0000</td><td>1.86</td><td>0.0000</td></tr><tr><td>A1G_07480</td><td>hypothetical protein A1G_07480</td><td>-2.62 (-3.02; -2.21)</td><td>-1.49</td><td>0.0001</td><td>2.51 (2.41; 2.62)</td><td>2.39</td><td>0.0000</td><td>1.59</td><td>0.0000</td></tr><tr><td>A1G_00185</td><td>hypothetical protein A1G_00185</td><td>ND</td><td>NS</td><td></td><td>2.02 (2.13; 1.92)</td><td>2.00</td><td>0.0000</td><td>1.74</td><td>0.0000</td></tr><tr><td>A1G_00820</td><td>hypothetical protein A1G_00820</td><td>ND</td><td>1.77</td><td>0.0001</td><td>-1.83 (-1.88; -1.78)</td><td>-4.00</td><td>0.0000</td><td>-2.22</td><td>0.0000</td></tr><tr><td>A1G_01380</td><td>hypothetical protein A1G_01380</td><td>ND</td><td>NS</td><td></td><td>2.71 (2.69; 2.73)</td><td>2.35</td><td>0.0000</td><td>1.96</td><td>0.0000</td></tr><tr><td>A1G_03000</td><td>hypothetical protein A1G_03000</td><td>ND</td><td>2.53</td><td>0.0000</td><td>-7.2 (-8.32; -6.07)</td><td>-7.14</td><td>0.0000</td><td>-2.78</td><td>0.0000</td></tr><tr><td>A1G_06745</td><td>hypothetical protein A1G_06745</td><td>ND</td><td>NS</td><td></td><td>2.82 (2.94; 2.69)</td><td>1.69</td><td>0.0000</td><td>1.85</td><td>0.0000</td></tr><tr><td>A1G_05315</td><td>chaperonin GroEL</td><td>ND</td><td>1.46</td><td>0.0006</td><td>-1.71 (-1.53; -1.88)</td><td>-2.27</td><td>0.0000</td><td>-1.54</td><td>0.0000</td></tr><tr><td>A1G_05630</td><td>cold shock-like protein</td><td>1.92 (1.98; 1.87)</td><td>1.36</td><td>0.0063</td><td>ND</td><td>-1.96</td><td>0.0000</td><td>-1.43</td><td>0.0002</td></tr></table>
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<table><tr><td></td><td></td><td colspan="3">Temperature shift</td><td colspan="3">Blood feeding</td><td colspan="2">Temperature shift + Blood feeding</td></tr><tr><td></td><td></td><td>Microarray</td><td colspan="2">RT-qPCR</td><td>Microarray</td><td colspan="2">RT-qPCR</td><td colspan="2">RT-qPCR</td></tr><tr><td>Gene ID</td><td>Annotation</td><td>Fold change (replicate 1; replicate 2)</td><td>Fold change</td><td>p-value</td><td>Fold change (replicate 1; replicate 2)</td><td>Fold change</td><td>p-value</td><td>Fold change</td><td>p-value</td></tr><tr><td>A1G_00295</td><td>cell surface antigen-like protein Sca10</td><td>ND</td><td>-1.67</td><td>0.0000</td><td>-2.33 (-2.39; -2.27)</td><td>-4.76</td><td>0.0000</td><td>-8.33</td><td>0.0000</td></tr><tr><td>A1G_00515</td><td>ADP,ATP carrier protein</td><td>ND</td><td>NS</td><td></td><td>-1.96 (-1.91; -2.02)</td><td>-2.17</td><td>0.0000</td><td>-2.13</td><td>0.0000</td></tr><tr><td>A1G_00520</td><td>glycerol-3-phosphate transporter</td><td>ND</td><td>NS</td><td></td><td>-1.73 (-1.62; -1.83)</td><td>-2.70</td><td>0.0000</td><td>-2.22</td><td>0.0000</td></tr><tr><td>A1G_00680</td><td>30S ribosomal protein S2</td><td>ND</td><td>1.41</td><td>0.0018</td><td>-2.46 (-2.62; -2.29)</td><td>-4.00</td><td>0.0000</td><td>-2.86</td><td>0.0000</td></tr><tr><td>A1G_00685</td><td>elongation factor Ts</td><td>ND</td><td>NS</td><td></td><td>-1.79 (-1.79; -1.78)</td><td>-2.94</td><td>0.0000</td><td>-2.70</td><td>0.0000</td></tr><tr><td>A1G_00810</td><td>type IV secretion system protein VirB3</td><td>ND</td><td>1.45</td><td>0.0016</td><td>-1.98 (-2.07; -1.89)</td><td>-2.78</td><td>0.0000</td><td>-1.92</td><td>0.0000</td></tr><tr><td>A1G_01445</td><td>cell surface antigen-like protein Sca8</td><td>ND</td><td>1.43</td><td>0.0080</td><td>-5.41 (-5.66; -5.15)</td><td>-12.5</td><td>0.0000</td><td>-8.33</td><td>0.0000</td></tr><tr><td>A1G_01495</td><td>ferredoxin</td><td>ND</td><td>NS</td><td></td><td>2.19 (2.30; 2.09)</td><td>1.36</td><td>0.0000</td><td>1.29</td><td>0.0012</td></tr><tr><td>A1G_01525</td><td>glutaredoxin 3</td><td>ND</td><td>-1,25</td><td>0.0019</td><td>2.68 (3.12; 2.23)</td><td>1.93</td><td>0.0000</td><td>1.54</td><td>0.0000</td></tr><tr><td>A1G_02205</td><td>virB9 protein</td><td>ND</td><td>-1.27</td><td>0.0045</td><td>2.38 (2.42; 2.35)</td><td>1.56</td><td>0.0000</td><td>NS</td><td></td></tr><tr><td>A1G_02230</td><td>virB10 protein</td><td>ND</td><td>NS</td><td></td><td>1.72 (1.69; 1.76)</td><td>1.55</td><td>0.0000</td><td>1.81</td><td>0.0000</td></tr><tr><td>A1G_02235</td><td>type IV secretion system ATPase VirB11</td><td>ND</td><td>-1.35</td><td>0.0002</td><td>1.68 (1.70; 1.66)</td><td>2.00</td><td>0.0000</td><td>1.49</td><td>0.0000</td></tr><tr><td>A1G_02240</td><td>type IV secretion system component VirD4</td><td>ND</td><td>-1.19</td><td>0.0196</td><td>1.83 (1.72; 1.94)</td><td>1.64</td><td>0.0000</td><td>1.38</td><td>0.0000</td></tr><tr><td>A1G_02555</td><td>thioredoxin peroxidase 1</td><td>ND</td><td>NS</td><td></td><td>1.67 (1.59; 1.75)</td><td>1.84</td><td>0.0000</td><td>2.06</td><td>0.0000</td></tr><tr><td>A1G_02680</td><td>16S rRNA-processing protein RimM</td><td>ND</td><td>NS</td><td></td><td>-2.06 (-2.18; -1.93)</td><td>-2.78</td><td>0.0000</td><td>-2.33</td><td>0.0000</td></tr></table>
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<table><tr><td>A1G_02785</td><td>site-specific tyrosine recombinase XerD</td><td>1.53 (1.53; 1.53)</td><td>1.86</td><td>0.0000</td><td>-2.69 (-2.52; -2.87)</td><td>-4.35</td><td>0.0000</td><td>-2.27</td><td>0.0000</td></tr><tr><td>A1G_03790</td><td>cell surface antigen</td><td>-1.79 (-1.99; -1.60)</td><td>-1.96</td><td>0.0000</td><td>ND</td><td>1.40</td><td>0.0002</td><td>0.72</td><td>0.0000</td></tr><tr><td>A1G_05315</td><td>chaperonin GroEL</td><td>ND</td><td>1.46</td><td>0.0006</td><td>-1.71 (-1.53; -1.88)</td><td>-2.27</td><td>0.0000</td><td>-1.54</td><td>0.0000</td></tr><tr><td>A1G_05630</td><td>cold shock-like protein</td><td>1.92 (1.98; 1.87)</td><td>1.36</td><td>0.0063</td><td>ND</td><td>-1.96</td><td>0.0000</td><td>-1.43</td><td>0.0002</td></tr><tr><td>A1G_05960</td><td>bicyclomycin resistance protein</td><td>1.57 (1.60; 1.53)</td><td>1.82</td><td>0.0000</td><td>ND</td><td>-5.88</td><td>0.0000</td><td>-3.33</td><td>0.0000</td></tr><tr><td>A1G_05625</td><td>ATP-dependent RNA helicase RhlE</td><td>ND</td><td>NS</td><td></td><td>-2.87 (-3.13; -2.62)</td><td>-4.76</td><td>0.0000</td><td>-3.85</td><td>0.0000</td></tr><tr><td>A1G_06265</td><td>ADP,ATP carrier protein</td><td>ND</td><td>1.47</td><td>0.0005</td><td>-2.30 (-2.20; -2.41)</td><td>-4.17</td><td>0.0000</td><td>-2.78</td><td>0.0000</td></tr><tr><td>A1G_06705</td><td>NADH dehydrogenase subunit J</td><td>ND</td><td>1.46</td><td>0.0018</td><td>-2.02 (-2.11; -1.93)</td><td>-4.17</td><td>0.0000</td><td>-2.86</td><td>0.0000</td></tr><tr><td>A1G_06710</td><td>NADH dehydrogenase subunit K</td><td>ND</td><td>NS</td><td></td><td>-4.08 (-4.59; -3.56)</td><td>-12.5</td><td>0.0000</td><td>-10.00</td><td>0.0000</td></tr><tr><td>A1G_06715</td><td>NADH dehydrogenase subunit L</td><td>ND</td><td>1.46</td><td>0.0124</td><td>-1.75 (-1.97; -1.54)</td><td>-7.14</td><td>0.0000</td><td>-5.00</td><td>0.0000</td></tr><tr><td>A1G_07470</td><td>DNA mismatch repair protein</td><td>-1.62 (-1.69; -1.54)</td><td>-1.22</td><td>0.0481</td><td>ND</td><td>1.32</td><td>0.0001</td><td>NS</td><td></td></tr><tr><td>A1G_00825</td><td>hypothetical protein A1G_00825</td><td>ND</td><td>1.62</td><td>0.0012</td><td>-1.68 (-1.77; -1.59)</td><td>-3.03</td><td>0.0000</td><td>-1.85</td><td>0.0000</td></tr><tr><td>A1G_02840</td><td>hypothetical protein A1G_02840</td><td>ND</td><td>NS</td><td></td><td>-3.03 (-3.30; -2.77)</td><td>-6.67</td><td>0.0000</td><td>-7.14</td><td>0.0000</td></tr><tr><td>A1G_06350</td><td>hypothetical protein A1G_06350</td><td>ND</td><td>NS</td><td></td><td>3.57 (4.12; 3.01)</td><td>1.76</td><td>0.0000</td><td>1.86</td><td>0.0000</td></tr><tr><td>A1G_07480</td><td>hypothetical protein A1G_07480</td><td>-2.62 (-3.02; -2.21)</td><td>-1.49</td><td>0.0001</td><td>2.51 (2.41; 2.62)</td><td>2.39</td><td>0.0000</td><td>1.59</td><td>0.0000</td></tr><tr><td>A1G_00185</td><td>hypothetical protein A1G_00185</td><td>ND</td><td>NS</td><td></td><td>2.02 (2.13; 1.92)</td><td>2.00</td><td>0.0000</td><td>1.74</td><td>0.0000</td></tr><tr><td>A1G_00820</td><td>hypothetical protein A1G_00820</td><td>ND</td><td>1.77</td><td>0.0001</td><td>-1.83 (-1.88; -1.78)</td><td>-4.00</td><td>0.0000</td><td>-2.22</td><td>0.0000</td></tr><tr><td>A1G_01380</td><td>hypothetical protein A1G_01380</td><td>ND</td><td>NS</td><td></td><td>2.71 (2.69; 2.73)</td><td>2.35</td><td>0.0000</td><td>1.96</td><td>0.0000</td></tr><tr><td>A1G_03000</td><td>hypothetical protein A1G_03000</td><td>ND</td><td>2.53</td><td>0.0000</td><td>-7.2 (-8.32; -6.07)</td><td>-7.14</td><td>0.0000</td><td>-2.78</td><td>0.0000</td></tr><tr><td>A1G_06745</td><td>hypothetical protein A1G_06745</td><td>ND</td><td>NS</td><td></td><td>2.82 (2.94; 2.69)</td><td>1.69</td><td>0.0000</td><td>1.85</td><td>0.0000</td></tr><tr><td>A1G_05315</td><td>chaperonin GroEL</td><td>ND</td><td>1.46</td><td>0.0006</td><td>-1.71 (-1.53; -1.88)</td><td>-2.27</td><td>0.0000</td><td>-1.54</td><td>0.0000</td></tr><tr><td>A1G_05630</td><td>cold shock-like protein</td><td>1.92 (1.98; 1.87)</td><td>1.36</td><td>0.0063</td><td>ND</td><td>-1.96</td><td>0.0000</td><td>-1.43</td><td>0.0002</td></tr></table>
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e54a466fa83106cc042334a74ffcf1c80a8da360d5b00d03707d3fc09d4ecf6d.png
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complex
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<table><tr><td>Time period 6 month intervals</td><td>Mean proportion of CVD services delivered</td><td>Difference from baseline</td><td>t-test</td><td><i>P*</i></td></tr><tr><td>Baseline</td><td>0.29</td><td>-</td><td>-</td><td>-</td></tr><tr><td>2</td><td>0.26</td><td>-0.04</td><td>-0.81</td><td>0.42</td></tr><tr><td>3</td><td>0.20</td><td>-0.09</td><td>-2.14</td><td>0.03</td></tr><tr><td>4</td><td>0.23</td><td>-0.06</td><td>-1.41</td><td>0.16</td></tr><tr><td>5</td><td>0.28</td><td>-0.01</td><td>-0.37</td><td>0.71</td></tr><tr><td>6</td><td>0.24</td><td>-0.05</td><td>-1.12</td><td>0.26</td></tr><tr><td colspan="5">AHC participation (intervention)</td></tr><tr><td>7</td><td>0.48</td><td>0.19</td><td>4.04</td><td>< 0.001</td></tr><tr><td>8</td><td>0.42</td><td>0.13</td><td>2.55</td><td>0.01</td></tr><tr><td>9</td><td>0.72</td><td>0.43</td><td>8.48</td><td>< 0.001</td></tr><tr><td>10</td><td>0.62</td><td>0.33</td><td>6.42</td><td>< 0.001</td></tr><tr><td>11</td><td>0.52</td><td>0.23</td><td>4.25</td><td>< 0.001</td></tr><tr><td>12</td><td>0.57</td><td>0.28</td><td>5.18</td><td>< 0.001</td></tr></table>
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<table><tr><td>Time period 6 month intervals</td><td>Mean proportion of CVD services delivered</td><td>Difference from baseline</td><td>t-test</td><td>P*</td></tr><tr><td>Baseline</td><td>0.29</td><td>-</td><td>-</td><td>-</td></tr><tr><td>2</td><td>0.26</td><td>-0.04</td><td>-0.81</td><td>0.42</td></tr><tr><td>3</td><td>0.20</td><td>-0.09</td><td>-2.14</td><td>0.03</td></tr><tr><td>4</td><td>0.23</td><td>-0.06</td><td>-1.41</td><td>0.16</td></tr><tr><td>5</td><td>0.28</td><td>-0.01</td><td>-0.37</td><td>0.71</td></tr><tr><td>6</td><td>0.24</td><td>-0.05</td><td>-1.12</td><td>0.26</td></tr><tr><td colspan="5">AHC participation (intervention)</td></tr><tr><td>7</td><td>0.48</td><td>0.19</td><td>4.04</td><td>< 0.001</td></tr></table>
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<table><tr><td>8</td><td>0.42</td><td>0.13</td><td>2.55</td><td>0.01</td></tr><tr><td>9</td><td>0.72</td><td>0.43</td><td>8.48</td><td>< 0.001</td></tr><tr><td>10</td><td>0.62</td><td>0.33</td><td>6.42</td><td>< 0.001</td></tr><tr><td>11</td><td>0.52</td><td>0.23</td><td>4.25</td><td>< 0.001</td></tr><tr><td>12</td><td>0.57</td><td>0.28</td><td>5.18</td><td>< 0.001</td></tr></table>
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cef9439ca8e8df66a2b7bc8de5c908cd5a974daa681878e8e0ef2a63d84f9012.png
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simple
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<table><tr><td>Assembler</td><td>Sequencing</td><td>Strains</td><td>Insert size</td><td>Read length (bp)</td><td>Number of reads</td><td>Raw read coverage</td><td>Assembled bases (Mb)</td><td>Contig coverage</td><td>Contig N50</td></tr><tr><td>FuzzyPath</td><td>Illumina</td><td>CAST/Ei</td><td>200 bp</td><td>36</td><td>173 million</td><td>65×</td><td>76.03</td><td>80.0%</td><td>2,315</td></tr><tr><td>Velvet*</td><td>Illumina</td><td>CAST/Ei</td><td>200 bp</td><td>36</td><td>173 million</td><td>65×</td><td>58.09</td><td>61.15%</td><td>391</td></tr><tr><td>ABySS</td><td>Illumina</td><td>CAST/Ei</td><td>200 bp</td><td>36</td><td>173 million</td><td>65×</td><td>72.80</td><td>76.63%</td><td>1,022</td></tr><tr><td>FuzzyPath</td><td>Illumina</td><td>A/J</td><td>200 bp</td><td>36</td><td>112 million</td><td>42×</td><td>55.87</td><td>58.8%</td><td>959</td></tr><tr><td>Phusion</td><td>Capillary</td><td>A/J</td><td>3-5 kb</td><td>400-900</td><td>357,100</td><td>2.5×</td><td>81.2</td><td>85.5%</td><td>3,377</td></tr><tr><td>FuzzyPath</td><td>Hybrid</td><td>A/J<sup>†</sup></td><td>Hybrid<sup>†</sup></td><td>Hybrid<sup>†</sup></td><td>Hybrid<sup>†</sup></td><td>Hybrid<sup>†</sup></td><td>85.54</td><td>90.0%</td><td>5,793</td></tr></table>
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<table><tr><td>Assembler</td><td>Sequencing</td><td>Strains</td><td>Insert size</td><td>Read length (bp)</td><td>Number of reads</td><td>Raw read coverage</td><td>Assembled bases (Mb)</td><td>Contig coverage</td><td>Contig N50</td></tr></table>
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<table><tr><td>FuzzyPath</td><td>Illumina</td><td>CAST/Ei</td><td>200 bp</td><td>36</td><td>173 million</td><td>65Γ</td><td>76.03</td><td>80.0%</td><td>2,315</td></tr><tr><td>Velvet*</td><td>Illumina</td><td>CAST/Ei</td><td>200 bp</td><td>36</td><td>173 million</td><td>65Γ</td><td>58.09</td><td>61.15%</td><td>391</td></tr><tr><td>ABySS</td><td>Illumina</td><td>CAST/Ei</td><td>200 bp</td><td>36</td><td>173 million</td><td>65Γ</td><td>72.80</td><td>76.63%</td><td>1,022</td></tr><tr><td>FuzzyPath</td><td>Illumina</td><td>A/J</td><td>200 bp</td><td>36</td><td>112 million</td><td>42Γ</td><td>55.87</td><td>58.8%</td><td>959</td></tr><tr><td>Phusion</td><td>Capillary</td><td>A/J</td><td>3-5 kb</td><td>400-900</td><td>357,100</td><td>2.5Γ</td><td>81.2</td><td>85.5%</td><td>3,377</td></tr><tr><td>FuzzyPath</td><td>Hybrid</td><td>A/Jβ </td><td>Hybridβ </td><td>Hybridβ </td><td>Hybridβ </td><td>Hybridβ </td><td>85.54</td><td>90.0%</td><td>5,793</td></tr></table>
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d96747221a2485d5d421c8b072f553a410c94c5d8ca21a41113d00d22f5a88c5.png
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complex
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<table><tr><td rowspan="2"></td><td colspan="2">Infant HIV exposure category</td><td rowspan="2"><i>p</i>-Value<sup>b</sup></td></tr><tr><td>HEU (<i>N</i> = 60)</td><td>HUU (<i>N</i> = 72<sup>a</sup>)</td></tr><tr><td colspan="4">Maternal characteristics</td></tr><tr><td>Mean (SD) maternal age at enrollment</td><td>28.0 (5.1)</td><td>25.9 (6.2)</td><td>0.05</td></tr><tr><td>Substance use during pregnancy, <i>N</i> (%)</td><td></td><td></td><td></td></tr><tr><td>Alcohol</td><td>13 (21.7)</td><td>8 (11.1)</td><td>0.15</td></tr><tr><td>Tobacco</td><td>16 (26.7)</td><td>10 (13.9)</td><td>0.08</td></tr><tr><td>Marijuana</td><td>4 (6.7)</td><td>0 (0.0)</td><td>0.04</td></tr><tr><td>Crack or cocaine</td><td>2 (3.3)</td><td>0 (0.0)</td><td>0.20</td></tr><tr><td>Maternal employment, <i>N</i> (%)</td><td>22 (36.7)</td><td>41 (56.9)</td><td>0.02</td></tr><tr><td>Mean (SD) years of completed education</td><td>7.6 (3.2)</td><td>9.3 (2.4)</td><td>0.001</td></tr><tr><td>Mean (SD) number of prior pregnancies</td><td>2.3 (1.9)</td><td>1.2 (1.3)</td><td><0.0001</td></tr><tr><td>Mean (SD) parity</td><td>1.8 (1.6)</td><td>1.0 (1.1)</td><td>0.001</td></tr><tr><td>Mean (SD) number of people living in the household</td><td>4.4 (2.0)</td><td>4.7 (1.7)</td><td>0.32</td></tr><tr><td>Mean (SD) CD4 count (cells/mm<sup>3</sup>) at hospital discharge</td><td>563.9 (266.7)</td><td>–</td><td>–</td></tr><tr><td>Mean (SD) CD4% at hospital discharge</td><td>32.0 (9.4)</td><td>–</td><td>–</td></tr><tr><td>Mean (SD) viral load (log<sub>10</sub> copies/mL) at hospital discharge</td><td>2.23 (0.81)</td><td>–</td><td>–</td></tr><tr><td>Viral load <400 copies/mL at hospital discharge, <i>N</i> (%)</td><td>51 (85.0)</td><td>–</td><td>–</td></tr><tr><td>ARV use during pregnancy, <i>N</i> (%)</td><td></td><td>–</td><td>–</td></tr><tr><td>Zidovudine monotherapy</td><td>25 (41.7)</td><td>–</td><td>–</td></tr><tr><td>Combination antiretrovirals</td><td>35 (58.3)</td><td></td><td></td></tr><tr><td colspan="4">Infant characteristics</td></tr><tr><td>Mean (SD) gestational age at birth (weeks)</td><td>38.7 (1.2)</td><td>39.2 (1.4)</td><td>0.01</td></tr><tr><td>Female gender, <i>N</i> (%)</td><td>25 (41.8)</td><td>36 (50.0)</td><td>0.38</td></tr><tr><td>Mean (SD) birth weight (g)</td><td>3176.4 (381.5)</td><td>3346.5 (422.7)</td><td>0.02</td></tr><tr><td>Small for gestational age (<10th percentile), <i>N</i> (%)</td><td>2 (3.3)</td><td>0 (0.0)</td><td>0.20</td></tr><tr><td>Large for gestational age (>90th percentile), <i>N</i> (%)</td><td>7 (11.7)</td><td>16 (22.2)</td><td>0.17</td></tr><tr><td>Not breastfeeding, <i>N</i> (%)</td><td>60 (100)</td><td>1 (1.4)</td><td><0.0001</td></tr></table>
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<table><tr><td rowspan="2"></td><td colspan="2">Infant HIV exposure category</td><td rowspan="2">p-Valueb</td></tr><tr><td>HEU (N = 60)</td><td>HUU (N = 72a)</td></tr><tr><td colspan="4">Maternal characteristics</td></tr><tr><td>Mean (SD) maternal age at enrollment</td><td>28.0 (5.1)</td><td>25.9 (6.2)</td><td>0.05</td></tr><tr><td>Substance use during pregnancy, N (%)</td><td></td><td></td><td></td></tr><tr><td>Alcohol</td><td>13 (21.7)</td><td>8 (11.1)</td><td>0.15</td></tr><tr><td>Tobacco</td><td>16 (26.7)</td><td>10 (13.9)</td><td>0.08</td></tr><tr><td>Marijuana</td><td>4 (6.7)</td><td>0 (0.0)</td><td>0.04</td></tr><tr><td>Crack or cocaine</td><td>2 (3.3)</td><td>0 (0.0)</td><td>0.20</td></tr><tr><td>Maternal employment, N (%)</td><td>22 (36.7)</td><td>41 (56.9)</td><td>0.02</td></tr><tr><td>Mean (SD) years of completed education</td><td>7.6 (3.2)</td><td>9.3 (2.4)</td><td>0.001</td></tr><tr><td>Mean (SD) number of prior pregnancies</td><td>2.3 (1.9)</td><td>1.2 (1.3)</td><td><0.0001</td></tr><tr><td>Mean (SD) parity</td><td>1.8 (1.6)</td><td>1.0 (1.1)</td><td>0.001</td></tr><tr><td>Mean (SD) number of people living in the household</td><td>4.4 (2.0)</td><td>4.7 (1.7)</td><td>0.32</td></tr></table>
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<table><tr><td>Mean (SD) CD4 count (cells/mm3) at hospital discharge</td><td>563.9 (266.7)</td><td>β</td><td>β</td></tr><tr><td>Mean (SD) CD4% at hospital discharge</td><td>32.0 (9.4)</td><td>β</td><td>β</td></tr><tr><td>Mean (SD) viral load (log10 copies/mL) at hospital discharge</td><td>2.23 (0.81)</td><td>β</td><td>β</td></tr><tr><td>Viral load <400 copies/mL at hospital discharge, N (%)</td><td>51 (85.0)</td><td>β</td><td>β</td></tr><tr><td>ARV use during pregnancy, N (%)</td><td></td><td>β</td><td>β</td></tr><tr><td>Zidovudine monotherapy</td><td>25 (41.7)</td><td>β</td><td>β</td></tr><tr><td>Combination antiretrovirals</td><td>35 (58.3)</td><td></td><td></td></tr><tr><td colspan="4">Infant characteristics</td></tr><tr><td>Mean (SD) gestational age at birth (weeks)</td><td>38.7 (1.2)</td><td>39.2 (1.4)</td><td>0.01</td></tr><tr><td>Female gender, N (%)</td><td>25 (41.8)</td><td>36 (50.0)</td><td>0.38</td></tr><tr><td>Mean (SD) birth weight (g)</td><td>3176.4 (381.5)</td><td>3346.5 (422.7)</td><td>0.02</td></tr><tr><td>Small for gestational age (<10th percentile), N (%)</td><td>2 (3.3)</td><td>0 (0.0)</td><td>0.20</td></tr><tr><td>Large for gestational age (>90th percentile), N (%)</td><td>7 (11.7)</td><td>16 (22.2)</td><td>0.17</td></tr><tr><td>Not breastfeeding, N (%)</td><td>60 (100)</td><td>1 (1.4)</td><td><0.0001</td></tr></table>
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a4ea613cc7faef2239f991b604f214940842d161c71c1a1012a9e7dba4c3ee44.png
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simple
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<table><tr><td>SOCIODEMOGRAPHIC AND CLINICAL CHARACTERISTICS</td><td>TREATMENT GROUP(N = 22)MEAN ± SD</td><td>WAITING LIST CONTROL GROUP (N = 24)MEAN ± SD</td><td>P</td></tr><tr><td>Age (years)</td><td>48.6 ± 11.2</td><td>53.0 ± 11.4</td><td>0.20</td></tr><tr><td>Sex (F/M)</td><td>15/7</td><td>20/4</td><td>0.27</td></tr><tr><td>BMI (kg/m<sup>2</sup>)</td><td>24.9 ± 4.0</td><td>24.1 ± 3.1</td><td>0.47</td></tr><tr><td>Pain at rest (PR)</td><td>45.5 ± 20.9</td><td>42.3 ± 18.0</td><td>0.58</td></tr><tr><td>Duration of neck pain (years)</td><td>6.3 ± 6.1</td><td>8.0 ± 7.6</td><td>0.41</td></tr><tr><td>Expected effectiveness of cupping therapy(VAS from 0 = not effective at all to 100 = highly effective)</td><td>82.8 ± 13.6</td><td>72.4 ± 21.3</td><td>0.06</td></tr></table>
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<table><tr><td>SOCIODEMOGRAPHIC AND CLINICAL CHARACTERISTICS</td><td>TREATMENT GROUP(N = 22)MEAN Β± SD</td><td>WAITING LIST CONTROL GROUP (N = 24)MEAN Β± SD</td><td>P</td></tr></table>
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<table><tr><td>Age (years)</td><td>48.6 Β± 11.2</td><td>53.0 Β± 11.4</td><td>0.20</td></tr><tr><td>Sex (F/M)</td><td>15/7</td><td>20/4</td><td>0.27</td></tr><tr><td>BMI (kg/m2)</td><td>24.9 Β± 4.0</td><td>24.1 Β± 3.1</td><td>0.47</td></tr><tr><td>Pain at rest (PR)</td><td>45.5 Β± 20.9</td><td>42.3 Β± 18.0</td><td>0.58</td></tr><tr><td>Duration of neck pain (years)</td><td>6.3 Β± 6.1</td><td>8.0 Β± 7.6</td><td>0.41</td></tr><tr><td>Expected effectiveness of cupping therapy(VAS from 0 = not effective at all to 100 = highly effective)</td><td>82.8 Β± 13.6</td><td>72.4 Β± 21.3</td><td>0.06</td></tr></table>
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c42a6d46fa87e0c776cf67d7f6b2c341fd9d9ee6fa52bebba08805c0badd578d.png
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complex
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<table><tr><td></td><td></td><td colspan="3">Formal only (n = 88)</td><td colspan="3">Formal and informal (n = 377)</td><td colspan="3">Informal only (n = 201)</td><td colspan="3">No help (n = 944)</td><td></td><td></td></tr><tr><td></td><td>N</td><td>n</td><td>%</td><td>(95% CI)</td><td>n</td><td>%</td><td>(95% CI)</td><td>n</td><td>%</td><td>(95% CI)</td><td>n</td><td>%</td><td>(95% CI)</td><td>Χ<sup>2</sup></td><td><i>p</i></td></tr><tr><td><i>Socio-demographic</i></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td><i>Gender</i></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>11.63</td><td><0.001</td></tr><tr><td>Male</td><td>702</td><td>36</td><td>5.2</td><td>(3.7-7.2)</td><td>65</td><td>8.9</td><td>(7.0-11.3)</td><td>130</td><td>17.9</td><td>(15.3-20.9</td><td>471</td><td>67.9</td><td>(64.3-71.3)</td><td></td><td></td></tr><tr><td>Female</td><td>908</td><td>52</td><td>5.8</td><td>(4.4-7.6)</td><td>136</td><td>14.7</td><td>(12.5-17.2)</td><td>247</td><td>25.9</td><td>(23.0-29.0)</td><td>473</td><td>53.6</td><td>(50.1-57.0)</td><td></td><td></td></tr><tr><td><i>Age</i></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>4.09</td><td><0.001</td></tr><tr><td>16-25</td><td>387</td><td>16</td><td>4.2</td><td>(2.6-6.7)</td><td>43</td><td>11.8</td><td>(8.7-15.8)</td><td>108</td><td>28.8</td><td>(24.3-33.6)</td><td>220</td><td>55.2</td><td>(50.1-60.2)</td><td></td><td></td></tr><tr><td>26-40</td><td>521</td><td>24</td><td>4.6</td><td>(3.1-6.9)</td><td>76</td><td>15.1</td><td>(12.2-18.7)</td><td>141</td><td>28.1</td><td>(24.2-32.4)</td><td>280</td><td>52.1</td><td>(47.5-56.6)</td><td></td><td></td></tr><tr><td>41-55</td><td>398</td><td>29</td><td>7.4</td><td>(5.1-10.4)</td><td>55</td><td>14.8</td><td>(11.5-18.9)</td><td>80</td><td>20.7</td><td>(16.9-25.1)</td><td>234</td><td>57.1</td><td>(52.0-62.1)</td><td></td><td></td></tr><tr><td>56 or older</td><td>304</td><td>19</td><td>6.2</td><td>(3.9-9.6)</td><td>27</td><td>9.4</td><td>(6.5-13.5)</td><td>48</td><td>16.5</td><td>(12.5-21.3)</td><td>210</td><td>68.0</td><td>(62.1-73.3)</td><td></td><td></td></tr><tr><td><i>Ethnic group</i></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>1.10</td><td>0.356</td></tr><tr><td>White</td><td>987</td><td>58</td><td>6.1</td><td>(4.7-7.9)</td><td>133</td><td>13.5</td><td>(11.3-15.9)</td><td>231</td><td>23.2</td><td>(20.5-26.2)</td><td>565</td><td>57.2</td><td>(53.8-60.6)</td><td></td><td></td></tr><tr><td>Black Caribbean</td><td>137</td><td>11</td><td>8.0</td><td>(4.4-14.2)</td><td>14</td><td>11.1</td><td>(6.7-17.8)</td><td>34</td><td>24.1</td><td>(17.0-32.9)</td><td>78</td><td>56.8</td><td>(47.8-65.5)</td><td></td><td></td></tr><tr><td>Black African</td><td>225</td><td>11</td><td>4.7</td><td>(2.6-8.4)</td><td>21</td><td>10.3</td><td>(6.7-15.6)</td><td>46</td><td>19.2</td><td>(14.5-25.0)</td><td>147</td><td>65.7</td><td>(58.6-72.2)</td><td></td><td></td></tr><tr><td>Asian</td><td>60</td><td>0</td><td>-</td><td></td><td>7</td><td>12.9</td><td>(6.3-24.5)</td><td>20</td><td>33.7</td><td>(21.9-48.0)</td><td>33</td><td>53.4</td><td>(40.1-66.3)</td><td></td><td></td></tr><tr><td>Other</td><td>199</td><td>8</td><td>4.0</td><td>(2.0-7.9)</td><td>25</td><td>12.8</td><td>(8.8-18.3)</td><td>45</td><td>23.8</td><td>(17.9-30.9)</td><td>121</td><td>59.4</td><td>(52.1-66.4)</td><td></td><td></td></tr><tr><td><i>Relationship status</i></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>4.48</td><td>0.004</td></tr><tr><td>Married/cohabitating</td><td>739</td><td>32</td><td>4.7</td><td>(3.3-6.7)</td><td>79</td><td>11.0</td><td>(8.8-13.6)</td><td>154</td><td>20.8</td><td>(17.9-24.0)</td><td>474</td><td>63.5</td><td>(59.6-67.2)</td><td></td><td></td></tr><tr><td>Non-married/non-cohabitating*</td><td>871</td><td>56</td><td>6.4</td><td>(4.9-8.3)</td><td>122</td><td>14.3</td><td>(12.0-17.0)</td><td>233</td><td>25.3</td><td>(22.3-28.6)</td><td>470</td><td>54.0</td><td>(50.3-57.6)</td><td></td><td></td></tr><tr><td><i>Migration status</i></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>2.07</td><td>0.102</td></tr><tr><td>Non-migrant</td><td>970</td><td>56</td><td>6.0</td><td>(4.6-7.8)</td><td>120</td><td>12.4</td><td>(10.4-14.8)</td><td>206</td><td>21.4</td><td>(18.8-24.3)</td><td>588</td><td>60.2</td><td>(56.8-63.5)</td><td></td><td></td></tr><tr><td>Migrant</td><td>633</td><td>29</td><td>4.6</td><td>(3.2-6.6)</td><td>81</td><td>13.5</td><td>(10.9-16.6)</td><td>170</td><td>26.2</td><td>(22.8-30.0)</td><td>353</td><td>55.7</td><td>(51.4-59.9)</td><td></td><td></td></tr><tr><td><i>Socio-economic</i></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td><i>Employment status</i></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>3.03</td><td>0.001</td></tr><tr><td>Employed</td><td>863</td><td>38</td><td>4.6</td><td>(3.3-6.2)</td><td>87</td><td>10.5</td><td>(8.5-12.8)</td><td>210</td><td>24.5</td><td>(21.6-27.7)</td><td>528</td><td>60.4</td><td>(56.9-63.9)</td><td></td><td></td></tr><tr><td>Unemployed</td><td>164</td><td>16</td><td>10.2</td><td>(6.2-16.2)</td><td>31</td><td>18.9</td><td>(13.5-25.7)</td><td>41</td><td>25.4</td><td>(19.0-33.1)</td><td>76</td><td>45.6</td><td>(37.8-53.5)</td><td></td><td></td></tr><tr><td>Student</td><td>239</td><td>12</td><td>4.9</td><td>(2.7-8.7)</td><td>28</td><td>12.7</td><td>(8.8-18.0)</td><td>63</td><td>26.9</td><td>(21.5-33.1)</td><td>136</td><td>55.5</td><td>(48.9-61.9)</td><td></td><td></td></tr><tr><td>Other</td><td>336</td><td>22</td><td>6.4</td><td>(4.2-9.8)</td><td>53</td><td>14.8</td><td>(11.3-19.1)</td><td>61</td><td>18.2</td><td>(14.2-23.0)</td><td>200</td><td>60.6</td><td>(54.9-65.9)</td><td></td><td></td></tr><tr><td><i>Education</i></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>1.90</td><td>0.049</td></tr><tr><td>No qualifications</td><td>230</td><td>16</td><td>6.5</td><td>(3.9-10.7)</td><td>28</td><td>12.0</td><td>(8.2-17.2)</td><td>37</td><td>15.9</td><td>(11.5-21.6)</td><td>149</td><td>65.6</td><td>(58.8-71.8)</td><td></td><td></td></tr><tr><td>GCSE</td><td>318</td><td>24</td><td>7.9</td><td>(5.2-11.7)</td><td>43</td><td>13.7</td><td>(10.2-18.2)</td><td>78</td><td>24.8</td><td>(20.2-30.0)</td><td>173</td><td>53.6</td><td>(47.9-59.3)</td><td></td><td></td></tr><tr><td>A-level</td><td>407</td><td>23</td><td>5.7</td><td>(3.8-8.6)</td><td>53</td><td>13.5</td><td>(10.2-17.6)</td><td>100</td><td>25.1</td><td>(20.9-29.8)</td><td>231</td><td>55.7</td><td>(50.6-60.7)</td><td></td><td></td></tr><tr><td>Degree or above</td><td>655</td><td>25</td><td>4.0</td><td>(2.7-5.9)</td><td>77</td><td>12.2</td><td>(9.8-15.1)</td><td>162</td><td>24.7</td><td>(21.5-28.3)</td><td>391</td><td>59.1</td><td>(55.1-63.0)</td><td></td><td></td></tr><tr><td><i>Annual household income</i></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>2.38</td><td>0.005</td></tr><tr><td>£0-5,475</td><td>133</td><td>11</td><td>7.1</td><td>(3.9-12.6)</td><td>36</td><td>27.3</td><td>(19.8-36.3)</td><td>20</td><td>16.1</td><td>(10.3-24.4)</td><td>66</td><td>49.5</td><td>(40.4-58.6)</td><td></td><td></td></tr><tr><td>£5,476-12,097</td><td>201</td><td>14</td><td>6.6</td><td>(3.8-11.2)</td><td>31</td><td>15.1</td><td>(10.7-21.1)</td><td>48</td><td>23.2</td><td>(17.7-29.9)</td><td>108</td><td>55.0</td><td>(47.7-62.1)</td><td></td><td></td></tr><tr><td>£12,098-20,753</td><td>196</td><td>7</td><td>4.0</td><td>(1.9-8.4)</td><td>23</td><td>12.2</td><td>(8.1-17.9)</td><td>49</td><td>24.5</td><td>(18.8-31.4)</td><td>117</td><td>59.3</td><td>(51.8-66.3)</td><td></td><td></td></tr><tr><td>£20,754-31,494</td><td>167</td><td>11</td><td>6.4</td><td>(3.5-11.3)</td><td>16</td><td>9.9</td><td>(6.1-15.7)</td><td>43</td><td>25.2</td><td>(18.9-32.8)</td><td>97</td><td>58.5</td><td>(50.4-66.2)</td><td></td><td></td></tr><tr><td>£31,495 or more</td><td>662</td><td>30</td><td>4.7</td><td>(3.3-6.7)</td><td>75</td><td>11.6</td><td>(9.3-14.4)</td><td>156</td><td>23.6</td><td>(20.4-27.1)</td><td>401</td><td>60.1</td><td>(56.2-63.9)</td><td></td><td></td></tr></table>
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<table><tr><td></td><td></td><td colspan="3">Formal only (n = 88)</td><td colspan="3">Formal and informal (n = 377)</td><td colspan="3">Informal only (n = 201)</td><td colspan="3">No help (n = 944)</td><td></td><td></td></tr><tr><td></td><td>N</td><td>n</td><td>%</td><td>(95% CI)</td><td>n</td><td>%</td><td>(95% CI)</td><td>n</td><td>%</td><td>(95% CI)</td><td>n</td><td>%</td><td>(95% CI)</td><td>Ξ§2</td><td>p</td></tr><tr><td>Socio-demographic</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Gender</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>11.63</td><td><0.001</td></tr><tr><td>Male</td><td>702</td><td>36</td><td>5.2</td><td>(3.7-7.2)</td><td>65</td><td>8.9</td><td>(7.0-11.3)</td><td>130</td><td>17.9</td><td>(15.3-20.9</td><td>471</td><td>67.9</td><td>(64.3-71.3)</td><td></td><td></td></tr><tr><td>Female</td><td>908</td><td>52</td><td>5.8</td><td>(4.4-7.6)</td><td>136</td><td>14.7</td><td>(12.5-17.2)</td><td>247</td><td>25.9</td><td>(23.0-29.0)</td><td>473</td><td>53.6</td><td>(50.1-57.0)</td><td></td><td></td></tr><tr><td>Age</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>4.09</td><td><0.001</td></tr><tr><td>16-25</td><td>387</td><td>16</td><td>4.2</td><td>(2.6-6.7)</td><td>43</td><td>11.8</td><td>(8.7-15.8)</td><td>108</td><td>28.8</td><td>(24.3-33.6)</td><td>220</td><td>55.2</td><td>(50.1-60.2)</td><td></td><td></td></tr><tr><td>26-40</td><td>521</td><td>24</td><td>4.6</td><td>(3.1-6.9)</td><td>76</td><td>15.1</td><td>(12.2-18.7)</td><td>141</td><td>28.1</td><td>(24.2-32.4)</td><td>280</td><td>52.1</td><td>(47.5-56.6)</td><td></td><td></td></tr><tr><td>41-55</td><td>398</td><td>29</td><td>7.4</td><td>(5.1-10.4)</td><td>55</td><td>14.8</td><td>(11.5-18.9)</td><td>80</td><td>20.7</td><td>(16.9-25.1)</td><td>234</td><td>57.1</td><td>(52.0-62.1)</td><td></td><td></td></tr><tr><td>56 or older</td><td>304</td><td>19</td><td>6.2</td><td>(3.9-9.6)</td><td>27</td><td>9.4</td><td>(6.5-13.5)</td><td>48</td><td>16.5</td><td>(12.5-21.3)</td><td>210</td><td>68.0</td><td>(62.1-73.3)</td><td></td><td></td></tr><tr><td>Ethnic group</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>1.10</td><td>0.356</td></tr><tr><td>White</td><td>987</td><td>58</td><td>6.1</td><td>(4.7-7.9)</td><td>133</td><td>13.5</td><td>(11.3-15.9)</td><td>231</td><td>23.2</td><td>(20.5-26.2)</td><td>565</td><td>57.2</td><td>(53.8-60.6)</td><td></td><td></td></tr><tr><td>Black Caribbean</td><td>137</td><td>11</td><td>8.0</td><td>(4.4-14.2)</td><td>14</td><td>11.1</td><td>(6.7-17.8)</td><td>34</td><td>24.1</td><td>(17.0-32.9)</td><td>78</td><td>56.8</td><td>(47.8-65.5)</td><td></td><td></td></tr><tr><td>Black African</td><td>225</td><td>11</td><td>4.7</td><td>(2.6-8.4)</td><td>21</td><td>10.3</td><td>(6.7-15.6)</td><td>46</td><td>19.2</td><td>(14.5-25.0)</td><td>147</td><td>65.7</td><td>(58.6-72.2)</td><td></td><td></td></tr><tr><td>Asian</td><td>60</td><td>0</td><td>-</td><td></td><td>7</td><td>12.9</td><td>(6.3-24.5)</td><td>20</td><td>33.7</td><td>(21.9-48.0)</td><td>33</td><td>53.4</td><td>(40.1-66.3)</td><td></td><td></td></tr><tr><td>Other</td><td>199</td><td>8</td><td>4.0</td><td>(2.0-7.9)</td><td>25</td><td>12.8</td><td>(8.8-18.3)</td><td>45</td><td>23.8</td><td>(17.9-30.9)</td><td>121</td><td>59.4</td><td>(52.1-66.4)</td><td></td><td></td></tr><tr><td>Relationship status</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>4.48</td><td>0.004</td></tr><tr><td>Married/cohabitating</td><td>739</td><td>32</td><td>4.7</td><td>(3.3-6.7)</td><td>79</td><td>11.0</td><td>(8.8-13.6)</td><td>154</td><td>20.8</td><td>(17.9-24.0)</td><td>474</td><td>63.5</td><td>(59.6-67.2)</td><td></td><td></td></tr><tr><td>Non-married/non-cohabitating*</td><td>871</td><td>56</td><td>6.4</td><td>(4.9-8.3)</td><td>122</td><td>14.3</td><td>(12.0-17.0)</td><td>233</td><td>25.3</td><td>(22.3-28.6)</td><td>470</td><td>54.0</td><td>(50.3-57.6)</td><td></td><td></td></tr><tr><td>Migration status</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>2.07</td><td>0.102</td></tr><tr><td>Non-migrant</td><td>970</td><td>56</td><td>6.0</td><td>(4.6-7.8)</td><td>120</td><td>12.4</td><td>(10.4-14.8)</td><td>206</td><td>21.4</td><td>(18.8-24.3)</td><td>588</td><td>60.2</td><td>(56.8-63.5)</td><td></td><td></td></tr><tr><td>Migrant</td><td>633</td><td>29</td><td>4.6</td><td>(3.2-6.6)</td><td>81</td><td>13.5</td><td>(10.9-16.6)</td><td>170</td><td>26.2</td><td>(22.8-30.0)</td><td>353</td><td>55.7</td><td>(51.4-59.9)</td><td></td><td></td></tr><tr><td>Socio-economic</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Employment status</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>3.03</td><td>0.001</td></tr><tr><td>Employed</td><td>863</td><td>38</td><td>4.6</td><td>(3.3-6.2)</td><td>87</td><td>10.5</td><td>(8.5-12.8)</td><td>210</td><td>24.5</td><td>(21.6-27.7)</td><td>528</td><td>60.4</td><td>(56.9-63.9)</td><td></td><td></td></tr><tr><td>Unemployed</td><td>164</td><td>16</td><td>10.2</td><td>(6.2-16.2)</td><td>31</td><td>18.9</td><td>(13.5-25.7)</td><td>41</td><td>25.4</td><td>(19.0-33.1)</td><td>76</td><td>45.6</td><td>(37.8-53.5)</td><td></td><td></td></tr><tr><td>Student</td><td>239</td><td>12</td><td>4.9</td><td>(2.7-8.7)</td><td>28</td><td>12.7</td><td>(8.8-18.0)</td><td>63</td><td>26.9</td><td>(21.5-33.1)</td><td>136</td><td>55.5</td><td>(48.9-61.9)</td><td></td><td></td></tr><tr><td>Other</td><td>336</td><td>22</td><td>6.4</td><td>(4.2-9.8)</td><td>53</td><td>14.8</td><td>(11.3-19.1)</td><td>61</td><td>18.2</td><td>(14.2-23.0)</td><td>200</td><td>60.6</td><td>(54.9-65.9)</td><td></td><td></td></tr><tr><td>Education</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>1.90</td><td>0.049</td></tr><tr><td>No qualifications</td><td>230</td><td>16</td><td>6.5</td><td>(3.9-10.7)</td><td>28</td><td>12.0</td><td>(8.2-17.2)</td><td>37</td><td>15.9</td><td>(11.5-21.6)</td><td>149</td><td>65.6</td><td>(58.8-71.8)</td><td></td><td></td></tr><tr><td>GCSE</td><td>318</td><td>24</td><td>7.9</td><td>(5.2-11.7)</td><td>43</td><td>13.7</td><td>(10.2-18.2)</td><td>78</td><td>24.8</td><td>(20.2-30.0)</td><td>173</td><td>53.6</td><td>(47.9-59.3)</td><td></td><td></td></tr><tr><td>A-level</td><td>407</td><td>23</td><td>5.7</td><td>(3.8-8.6)</td><td>53</td><td>13.5</td><td>(10.2-17.6)</td><td>100</td><td>25.1</td><td>(20.9-29.8)</td><td>231</td><td>55.7</td><td>(50.6-60.7)</td><td></td><td></td></tr><tr><td>Degree or above</td><td>655</td><td>25</td><td>4.0</td><td>(2.7-5.9)</td><td>77</td><td>12.2</td><td>(9.8-15.1)</td><td>162</td><td>24.7</td><td>(21.5-28.3)</td><td>391</td><td>59.1</td><td>(55.1-63.0)</td><td></td><td></td></tr><tr><td>Annual household income</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>2.38</td><td>0.005</td></tr><tr><td>Β£0-5,475</td><td>133</td><td>11</td><td>7.1</td><td>(3.9-12.6)</td><td>36</td><td>27.3</td><td>(19.8-36.3)</td><td>20</td><td>16.1</td><td>(10.3-24.4)</td><td>66</td><td>49.5</td><td>(40.4-58.6)</td><td></td><td></td></tr><tr><td>Β£5,476-12,097</td><td>201</td><td>14</td><td>6.6</td><td>(3.8-11.2)</td><td>31</td><td>15.1</td><td>(10.7-21.1)</td><td>48</td><td>23.2</td><td>(17.7-29.9)</td><td>108</td><td>55.0</td><td>(47.7-62.1)</td><td></td><td></td></tr><tr><td>Β£12,098-20,753</td><td>196</td><td>7</td><td>4.0</td><td>(1.9-8.4)</td><td>23</td><td>12.2</td><td>(8.1-17.9)</td><td>49</td><td>24.5</td><td>(18.8-31.4)</td><td>117</td><td>59.3</td><td>(51.8-66.3)</td><td></td><td></td></tr><tr><td>Β£20,754-31,494</td><td>167</td><td>11</td><td>6.4</td><td>(3.5-11.3)</td><td>16</td><td>9.9</td><td>(6.1-15.7)</td><td>43</td><td>25.2</td><td>(18.9-32.8)</td><td>97</td><td>58.5</td><td>(50.4-66.2)</td><td></td><td></td></tr></table>
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<table><tr><td></td><td></td><td colspan="3">Formal only (n = 88)</td><td colspan="3">Formal and informal (n = 377)</td><td colspan="3">Informal only (n = 201)</td><td colspan="3">No help (n = 944)</td></tr><tr><td></td><td>N</td><td>n</td><td>%</td><td>(95% CI)</td><td>n</td><td>%</td><td>(95% CI)</td><td>n</td><td>%</td><td>(95% CI)</td><td>n</td><td>%</td><td>(95% CI)</td></tr><tr><td>Β£31,495 or more</td><td>662</td><td>30</td><td>4.7</td><td>(3.3-6.7)</td><td>75</td><td>11.6</td><td>(9.3-14.4)</td><td>156</td><td>23.6</td><td>(20.4-27.1)</td><td>401</td><td>60.1</td><td>(56.2-63.9)</td></tr></table>
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26133077f83620aec1430879ceac6c0e73a3566982e4c83b78e7b53e1d2047e0.png
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complex
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<table><tr><td>Patient no. (with cartilage damage)</td><td colspan="2">Teres ligament</td><td colspan="2">Joint capsule</td></tr><tr><td> </td><td>S100</td><td>Substance P</td><td>S100</td><td>Substance P</td></tr><tr><td>1.</td><td>+</td><td>+</td><td>-</td><td>-</td></tr><tr><td>4.</td><td>-</td><td>+</td><td>+</td><td>-</td></tr><tr><td>5.</td><td>+</td><td>+</td><td>+</td><td>+</td></tr><tr><td>9.</td><td>+</td><td>+</td><td>-</td><td>-</td></tr><tr><td>11.</td><td>+</td><td>+</td><td>+</td><td>+</td></tr><tr><td>12.</td><td>+</td><td>+</td><td>-</td><td>-</td></tr><tr><td>15.</td><td>+</td><td>+</td><td>-</td><td>-</td></tr><tr><td>16.</td><td>+</td><td>+</td><td>+</td><td>-</td></tr><tr><td>17.</td><td>-</td><td>-</td><td>-</td><td>+</td></tr></table>
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<table><tr><td>Patient no. (with cartilage damage)</td><td colspan="2">Teres ligament</td><td colspan="2">Joint capsule</td></tr><tr><td></td><td>S100</td><td>Substance P</td><td>S100</td><td>Substance P</td></tr><tr><td>1.</td><td>+</td><td>+</td><td>-</td><td>-</td></tr><tr><td>4.</td><td>-</td><td>+</td><td>+</td><td>-</td></tr><tr><td>5.</td><td>+</td><td>+</td><td>+</td><td>+</td></tr><tr><td>9.</td><td>+</td><td>+</td><td>-</td><td>-</td></tr><tr><td>11.</td><td>+</td><td>+</td><td>+</td><td>+</td></tr><tr><td>12.</td><td>+</td><td>+</td><td>-</td><td>-</td></tr><tr><td>15.</td><td>+</td><td>+</td><td>-</td><td>-</td></tr><tr><td></td><td>+</td><td>+</td><td></td><td>-</td></tr></table>
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<table><tr><td>Patient no. (with cartilage damage)</td><td colspan="2">Teres ligament</td><td colspan="2">Joint capsule</td></tr><tr><td></td><td>S100</td><td>Substance P</td><td>S100</td><td>Substance P</td></tr><tr><td>16.</td><td></td><td></td><td>+</td><td></td></tr><tr><td>17.</td><td>-</td><td>-</td><td>-</td><td>+</td></tr></table>
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df8cce802700a57e4d40cf52185fc16c9aca73eeb5c8615eff2910b5dc82ce57.png
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complex
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<table><tr><td colspan="6">Extracted peatland drains</td></tr><tr><td>Linear validation dataset</td><td>Drain</td><td>No drain</td><td></td><td>Total</td><td>Producer accuracy</td></tr><tr><td>Drain</td><td>193</td><td>131</td><td></td><td>324</td><td>0.60</td></tr><tr><td>No drain</td><td>39</td><td>2637</td><td></td><td>2676</td><td>0.99</td></tr><tr><td></td><td></td><td></td><td>2830</td><td></td><td></td></tr><tr><td>Total</td><td>232</td><td>2768</td><td></td><td>3000</td><td></td></tr><tr><td>User accuracy</td><td>0.83</td><td>0.95</td><td></td><td></td><td></td></tr><tr><td>Kappa statistic</td><td>0.66</td><td></td><td></td><td>OA</td><td>0.94</td></tr></table>
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<table><tr><td colspan="6">Extracted peatland drains</td></tr><tr><td>Linear validation dataset</td><td>Drain</td><td>No drain</td><td></td><td>Total</td><td>Producer accuracy</td></tr><tr><td>Drain</td><td>193</td><td>131</td><td></td><td>324</td><td>0.60</td></tr><tr><td>No drain</td><td>39</td><td>2637</td><td></td><td>2676</td><td>0.99</td></tr></table>
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<table><tr><td></td><td></td><td></td><td>2830</td><td></td><td></td></tr><tr><td>Total</td><td>232</td><td>2768</td><td></td><td>3000</td><td></td></tr><tr><td>User accuracy</td><td>0.83</td><td>0.95</td><td></td><td></td><td></td></tr><tr><td>Kappa statistic</td><td>0.66</td><td></td><td></td><td>OA</td><td>0.94</td></tr></table>
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850199692d122819e314b0c44a1ce564d3f34b909e532bb27dcafe8515ca25aa.png
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complex
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<table><tr><td>Genes</td><td>Identity</td><td>Major function</td></tr><tr><td colspan="3">Genes that promote neuronal integrity during aging</td></tr><tr><td><i>daf-16</i></td><td>FoxO transcription factor</td><td>Upregulation of stress resistance genes</td></tr><tr><td><i>hsf-1</i></td><td>Heat shock transcription factor</td><td>Upregulation of small heat shock protein expression</td></tr><tr><td><i>mec-1</i></td><td>EGF and Kunitz domain-containing ECM protein</td><td>Mechanosensory transduction, nerve attachment</td></tr><tr><td><i>mec-2</i></td><td>Stomatin-like</td><td>Mechanosensory transduction</td></tr><tr><td><i>mec-4</i></td><td>DEG/ENaC family sodium channel</td><td>Mechanosensory transduction</td></tr><tr><td><i>mec-5</i></td><td>Atypical collagen</td><td>Mechanosensory transduction, nerve attachment</td></tr><tr><td><i>mec-6</i></td><td>Paraoxonase</td><td>Mechanosensory transduction</td></tr><tr><td><i>mec-9</i></td><td>EGF and Kunitz domain-containing ECM protein</td><td>Mechanosensory transduction, nerve attachment</td></tr><tr><td><i>mec-10</i></td><td>DEG/ENaC family sodium channel</td><td>Mechanosensory transduction</td></tr><tr><td><i>mec-12</i></td><td>α-tubulin</td><td>Mechanosensory transduction, axon transport</td></tr><tr><td><i>jkk-1</i></td><td>JNK kinase</td><td>Activation of JNK; synaptic vesicle localization</td></tr><tr><td><i>jnk-1</i></td><td>c-Jun N-terminus kinase (JNK)</td><td>Heat and stress response; locomotion</td></tr><tr><td><i>mek-1</i></td><td>Mitogen activated protein kinase (MAPK) kinase/MKK7</td><td>Stress and starvation response</td></tr><tr><td><i>lmn-1</i></td><td>Laminin</td><td>Regulation of nuclear organization and function</td></tr><tr><td><i>ptl-1</i></td><td>Tau/microtubules-associated protein</td><td>Microtubule stabilization?</td></tr><tr><td><i>unc-13</i></td><td>Munc-13</td><td>Synaptic vesicle fusion</td></tr><tr><td><i>unc-18</i></td><td>Munc-18</td><td>Synaptic vesicle docking</td></tr><tr><td colspan="3">Genes that accelerate neuronal aging</td></tr><tr><td><i>daf-2</i></td><td>Insulin-like growth factor receptor</td><td>Larval development, dauer formation, etc</td></tr><tr><td><i>dgk-1</i></td><td>Diacylglycerol kinase</td><td>Inhibition of synapse transmission</td></tr><tr><td><i>slo-1</i></td><td>BK-type potassium channel</td><td>Muscle inactivation, neuronal excitability, etc</td></tr></table>
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<table><tr><td>Genes</td><td>Identity</td><td>Major function</td></tr><tr><td colspan="3">Genes that promote neuronal integrity during aging</td></tr><tr><td>daf-16</td><td>FoxO transcription factor</td><td>Upregulation of stress resistance genes</td></tr><tr><td>hsf-1</td><td>Heat shock transcription factor</td><td>Upregulation of small heat shock protein expression</td></tr><tr><td>mec-1</td><td>EGF and Kunitz domain-containing ECM protein</td><td>Mechanosensory transduction, nerve attachment</td></tr><tr><td>mec-2</td><td>Stomatin-like</td><td>Mechanosensory transduction</td></tr><tr><td>mec-4</td><td>DEG/ENaC family sodium channel</td><td>Mechanosensory transduction</td></tr><tr><td>mec-5</td><td>Atypical collagen</td><td>Mechanosensory transduction, nerve attachment</td></tr><tr><td>mec-6</td><td>Paraoxonase</td><td>Mechanosensory transduction</td></tr></table>
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<table><tr><td>mec-9</td><td>EGF and Kunitz domain-containing ECM protein</td><td>Mechanosensory transduction, nerve attachment</td></tr><tr><td>mec-10</td><td>DEG/ENaC family sodium channel</td><td>Mechanosensory transduction</td></tr><tr><td>mec-12</td><td>Ξ±-tubulin</td><td>Mechanosensory transduction, axon transport</td></tr><tr><td>jkk-1</td><td>JNK kinase</td><td>Activation of JNK; synaptic vesicle localization</td></tr><tr><td>jnk-1</td><td>c-Jun N-terminus kinase (JNK)</td><td>Heat and stress response; locomotion</td></tr><tr><td>mek-1</td><td>Mitogen activated protein kinase (MAPK) kinase/MKK7</td><td>Stress and starvation response</td></tr><tr><td>lmn-1</td><td>Laminin</td><td>Regulation of nuclear organization and function</td></tr><tr><td>ptl-1</td><td>Tau/microtubules-associated protein</td><td>Microtubule stabilization?</td></tr><tr><td>unc-13</td><td>Munc-13</td><td>Synaptic vesicle fusion</td></tr><tr><td>unc-18</td><td>Munc-18</td><td>Synaptic vesicle docking</td></tr><tr><td colspan="3">Genes that accelerate neuronal aging</td></tr><tr><td>daf-2</td><td>Insulin-like growth factor receptor</td><td>Larval development, dauer formation, etc</td></tr><tr><td>dgk-1</td><td>Diacylglycerol kinase</td><td>Inhibition of synapse transmission</td></tr><tr><td>slo-1</td><td>BK-type potassium channel</td><td>Muscle inactivation, neuronal excitability, etc</td></tr></table>
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c6d55887588146f3974e371052a04e287ae4c5503456e3f03aa5d7ba8b20e88a.png
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simple
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<table><tr><td>Ribosomal protein gene</td><td>Chromosomal assignment in <i>C. elegans</i></td><td>Number of 5' codons omitted from analysis</td><td>Coding nucleotides used for analysis</td></tr><tr><td><i>rpl-1</i></td><td>III</td><td>3</td><td>642</td></tr><tr><td><i>rpl-2</i></td><td>V</td><td>0</td><td>783</td></tr><tr><td><i>rpl-10</i></td><td>II</td><td>5</td><td>630</td></tr><tr><td><i>rpl-14</i></td><td>I</td><td>5</td><td>402</td></tr><tr><td><i>rpl-16</i></td><td>III</td><td>5</td><td>597</td></tr><tr><td><i>rpl-23</i></td><td>III</td><td>5</td><td>408</td></tr><tr><td><i>rpl-26</i></td><td>II</td><td>3</td><td>423</td></tr><tr><td><i>rpl-27</i></td><td>I</td><td>6</td><td>393</td></tr><tr><td><i>rpl-27a</i></td><td>I</td><td>8</td><td>420</td></tr><tr><td><i>rpl-28</i></td><td>V</td><td>7</td><td>387</td></tr><tr><td><i>rpl-29</i></td><td>IV</td><td>0</td><td>189</td></tr><tr><td><i>rpl-30</i></td><td>I</td><td>4</td><td>339</td></tr><tr><td><i>rpl-31</i></td><td>I</td><td>8</td><td>345</td></tr><tr><td><i>rpl-32</i></td><td>II</td><td>8</td><td>381</td></tr><tr><td><i>rpl-34</i></td><td>IV</td><td>4</td><td>330</td></tr><tr><td><i>rpl-35</i></td><td>III</td><td>8</td><td>348</td></tr><tr><td><i>rpl-38</i></td><td>V</td><td>6</td><td>195</td></tr><tr><td><i>rpl-39</i></td><td>V</td><td>8</td><td>132</td></tr><tr><td><i>rps-1</i></td><td>III</td><td>6</td><td>762</td></tr><tr><td><i>rps-8</i></td><td>IV</td><td>3</td><td>618</td></tr><tr><td><i>rps-14</i></td><td>III</td><td>8</td><td>435</td></tr><tr><td><i>rps-20</i></td><td>I</td><td>0</td><td>357</td></tr><tr><td><i>rps-21</i></td><td>III</td><td>0</td><td>267</td></tr><tr><td><i>rps-24</i></td><td>IV</td><td>0</td><td>396</td></tr><tr><td><i>rps-25</i></td><td>IV</td><td>7</td><td>336</td></tr><tr><td><i>rps-27</i></td><td>V</td><td>0</td><td>255</td></tr><tr><td><i>rps-28</i></td><td>IV</td><td>0</td><td>201</td></tr><tr><td>Total number of nucleotides:</td><td></td><td></td><td>10,971</td></tr></table>
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<table><tr><td>Ribosomal protein gene</td><td>Chromosomal assignment in C. elegans</td><td>Number of 5' codons omitted from analysis</td><td>Coding nucleotides used for analysis</td></tr><tr><td>rpl-1</td><td>III</td><td>3</td><td>642</td></tr><tr><td>rpl-2</td><td>V</td><td>0</td><td>783</td></tr><tr><td>rpl-10</td><td>II</td><td>5</td><td>630</td></tr><tr><td>rpl-14</td><td>I</td><td>5</td><td>402</td></tr><tr><td>rpl-16</td><td>III</td><td>5</td><td>597</td></tr><tr><td>rpl-23</td><td>III</td><td>5</td><td>408</td></tr><tr><td>rpl-26</td><td>II</td><td>3</td><td>423</td></tr><tr><td>rpl-27</td><td>I</td><td>6</td><td>393</td></tr><tr><td>rpl-27a</td><td>I</td><td>8</td><td>420</td></tr><tr><td>rpl-28</td><td>V</td><td>7</td><td>387</td></tr><tr><td>rpl-29</td><td>IV</td><td>0</td><td>189</td></tr><tr><td>rpl-30</td><td>I</td><td>4</td><td>339</td></tr><tr><td>rpl-31</td><td>I</td><td>8</td><td>345</td></tr><tr><td>rpl-32</td><td>II</td><td>8</td><td>381</td></tr><tr><td>rpl-34</td><td>IV</td><td>4</td><td>330</td></tr><tr><td>rpl-35</td><td>III</td><td>8</td><td>348</td></tr><tr><td>rpl-38</td><td>V</td><td>6</td><td>195</td></tr><tr><td>rpl-39</td><td>V</td><td>8</td><td>132</td></tr><tr><td>rps-1</td><td>III</td><td>6</td><td>762</td></tr><tr><td>rps-8</td><td>IV</td><td>3</td><td>618</td></tr><tr><td>rps-14</td><td>III</td><td>8</td><td>435</td></tr><tr><td>rps-20</td><td>I</td><td>0</td><td>357</td></tr></table>
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<table><tr><td>Ribosomal protein gene</td><td>Chromosomal assignment in C. elegans</td><td>Number of 5' codons omitted from analysis</td><td>Coding nucleotides used for analysis</td></tr><tr><td>rps-21</td><td>III</td><td>0</td><td>267</td></tr><tr><td>rps-24</td><td>IV</td><td>0</td><td>396</td></tr><tr><td>rps-25</td><td>IV</td><td>7</td><td>336</td></tr><tr><td>rps-27</td><td>V</td><td>0</td><td>255</td></tr><tr><td>rps-28</td><td>IV</td><td>0</td><td>201</td></tr><tr><td>Total number of nucleotides:</td><td></td><td></td><td>10,971</td></tr></table>
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22981e8a58d212641e3bb7a9398229d837cb4be4dd3b57b9e3797877b4f41de5.png
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simple
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<table><tr><td>Primary antibody</td><td>Manufacturer</td><td>Cat. number</td><td>Dilution</td><td>Source</td></tr><tr><td>OCT4</td><td>Abcam</td><td>ab18976</td><td>1/250</td><td>Rabbit</td></tr><tr><td>NANOG</td><td>Abcam</td><td>ab21624</td><td>1/100</td><td>Rabbit</td></tr><tr><td>SSEA4</td><td>Abcam</td><td>ab16287</td><td>1/100</td><td>Mouse</td></tr><tr><td>TRA-1-81</td><td>Abcam</td><td>ab16289</td><td>1/100</td><td>Mouse</td></tr><tr><td>TRA-1-60</td><td>Abcam</td><td>ab16288</td><td>1/100</td><td>Mouse</td></tr><tr><td>SOX1</td><td>Abcam</td><td>ab87775</td><td>1/200</td><td>Rabbit</td></tr><tr><td>PAX6</td><td>DSHB</td><td>3B5</td><td>1/50</td><td>Mouse</td></tr><tr><td>OTX2</td><td>Abcam</td><td>ab21990</td><td>1/500</td><td>Rabbit</td></tr><tr><td>LHX2</td><td>Santa Cruz Biotechnology</td><td>sc-81311</td><td>1/200</td><td>Mouse</td></tr><tr><td>SIX3</td><td>Rockland</td><td>600-401-A26</td><td>1/500</td><td>Rabbit</td></tr><tr><td>MCM2</td><td>Abcam</td><td>ab4461</td><td>1/400</td><td>Rabbit</td></tr><tr><td>CHX10</td><td>Millipore</td><td>ab9016</td><td>1/200</td><td>Sheep</td></tr><tr><td>FIBRONECTIN</td><td>Abcam</td><td>ab2413</td><td>1/200</td><td>Rabbit</td></tr><tr><td>ZO-1</td><td>Thermo Fisher</td><td>33-9100</td><td>1/400</td><td>Mouse</td></tr><tr><td>BRN3</td><td>Santa Cruz Biotechnology</td><td>sc-6026</td><td>1/200</td><td>Goat</td></tr><tr><td>AP2</td><td>DSHB</td><td>3B5a</td><td>1/35</td><td>Mouse</td></tr><tr><td>PROX1</td><td>Abcam</td><td>ab101851</td><td>1/2000</td><td>Rabbit</td></tr><tr><td>PKC-<i>α</i></td><td>Abcam</td><td>ab32376</td><td>1/2000</td><td>Rabbit</td></tr><tr><td>CRALBP</td><td>Abcam</td><td>ab15051</td><td>1/500</td><td>Mouse</td></tr><tr><td>Rhodopsin</td><td>Abcam</td><td>ab3267</td><td>1/200</td><td>Mouse</td></tr><tr><td>S opsin</td><td>Gift from Dr. Jeremy Nathans</td><td>/</td><td>1/5000</td><td>Rabbit</td></tr><tr><td>L/M opsin</td><td>Gift from Dr. Jeremy Nathans</td><td>/</td><td>1/5000</td><td>Rabbit</td></tr><tr><td>Recoverin</td><td>Millipore</td><td>ab5585</td><td>1/500</td><td>Rabbit</td></tr><tr><td>PDE6<i>α</i></td><td>Abcam</td><td>ab5665</td><td>1/100</td><td>Rabbit</td></tr><tr><td>Gt<i>α</i>-1</td><td>Santa Cruz Biotechnology</td><td>sc-136143</td><td>1/2000</td><td>Mouse</td></tr></table>
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<table><tr><td>Primary antibody</td><td>Manufacturer</td><td>Cat. number</td><td>Dilution</td><td>Source</td></tr><tr><td>OCT4</td><td>Abcam</td><td>ab18976</td><td>1/250</td><td>Rabbit</td></tr><tr><td>NANOG</td><td>Abcam</td><td>ab21624</td><td>1/100</td><td>Rabbit</td></tr><tr><td>SSEA4</td><td>Abcam</td><td>ab16287</td><td>1/100</td><td>Mouse</td></tr><tr><td>TRA-1-81</td><td>Abcam</td><td>ab16289</td><td>1/100</td><td>Mouse</td></tr><tr><td>TRA-1-60</td><td>Abcam</td><td>ab16288</td><td>1/100</td><td>Mouse</td></tr><tr><td>SOX1</td><td>Abcam</td><td>ab87775</td><td>1/200</td><td>Rabbit</td></tr><tr><td>PAX6</td><td>DSHB</td><td>3B5</td><td>1/50</td><td>Mouse</td></tr><tr><td>OTX2</td><td>Abcam</td><td>ab21990</td><td>1/500</td><td>Rabbit</td></tr><tr><td>LHX2</td><td>Santa Cruz Biotechnology</td><td>sc-81311</td><td>1/200</td><td>Mouse</td></tr><tr><td>SIX3</td><td>Rockland</td><td>600-401-A26</td><td>1/500</td><td>Rabbit</td></tr><tr><td>MCM2</td><td>Abcam</td><td>ab4461</td><td>1/400</td><td>Rabbit</td></tr><tr><td>CHX10</td><td>Millipore</td><td>ab9016</td><td>1/200</td><td>Sheep</td></tr><tr><td>FIBRONECTIN</td><td>Abcam</td><td>ab2413</td><td>1/200</td><td>Rabbit</td></tr><tr><td>ZO-1</td><td>Thermo Fisher</td><td>33-9100</td><td>1/400</td><td>Mouse</td></tr><tr><td>BRN3</td><td>Santa Cruz Biotechnology</td><td>sc-6026</td><td>1/200</td><td>Goat</td></tr><tr><td>AP2</td><td>DSHB</td><td>3B5a</td><td>1/35</td><td>Mouse</td></tr><tr><td>PROX1</td><td>Abcam</td><td>ab101851</td><td>1/2000</td><td>Rabbit</td></tr><tr><td>PKC-Ξ±</td><td>Abcam</td><td>ab32376</td><td>1/2000</td><td>Rabbit</td></tr><tr><td>CRALBP</td><td>Abcam</td><td>ab15051</td><td>1/500</td><td>Mouse</td></tr></table>
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<table><tr><td>Rhodopsin</td><td>Abcam</td><td>ab3267</td><td>1/200</td><td>Mouse</td></tr><tr><td>S opsin</td><td>Gift from Dr. Jeremy Nathans</td><td>/</td><td>1/5000</td><td>Rabbit</td></tr><tr><td>L/M opsin</td><td>Gift from Dr. Jeremy Nathans</td><td>/</td><td>1/5000</td><td>Rabbit</td></tr><tr><td>Recoverin</td><td>Millipore</td><td>ab5585</td><td>1/500</td><td>Rabbit</td></tr><tr><td>PDE6Ξ±</td><td>Abcam</td><td>ab5665</td><td>1/100</td><td>Rabbit</td></tr><tr><td>GtΞ±-1</td><td>Santa Cruz Biotechnology</td><td>sc-136143</td><td>1/2000</td><td>Mouse</td></tr></table>
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605d9ca7ecbab031e591ecfdd3ee2ffcba223283200ff0549003d9c1f81c009a.png
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simple
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<table><tr><td> </td><td>Males N (%)</td><td>Females N (%)</td><td>Age in years median (Range)</td></tr><tr><td>Balochistan</td><td>52 (55%)</td><td>42 (45%)</td><td>29 (4 to 70)</td></tr><tr><td>Islamabad</td><td>62 (72%)</td><td>23 (28%)</td><td>26 (3 to 75)</td></tr><tr><td>KPK</td><td>231 (63%)</td><td>133 (37%)</td><td>22 (0.3 to 75)</td></tr><tr><td>Punjab</td><td>126 (64%)</td><td>71 (36%)</td><td>24 (0.4 to 65)</td></tr><tr><td>Sindh</td><td>38 (62%)</td><td>23 (38%)</td><td>28 (0.3 to 65)</td></tr></table>
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<table><tr><td></td><td>Males N (%)</td><td>Females N (%)</td><td>Age in years median (Range)</td></tr><tr><td>Balochistan</td><td>52 (55%)</td><td>42 (45%)</td><td>29 (4 to 70)</td></tr><tr><td>Islamabad</td><td>62 (72%)</td><td>23 (28%)</td><td>26 (3 to 75)</td></tr><tr><td>KPK</td><td>231 (63%)</td><td>133 (37%)</td><td>22 (0.3 to 75)</td></tr><tr><td>Punjab</td><td>126 (64%)</td><td>71 (36%)</td><td>24 (0.4 to 65)</td></tr></table>
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<table><tr><td></td><td>Males N (%)</td><td>Females N (%)</td><td>Age in years median (Range)</td></tr><tr><td>Sindh</td><td>38 (62%)</td><td>23 (38%)</td><td>28 (0.3 to 65)</td></tr></table>
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04f10f9ea4c368848673cb4ca003d2d9ebd5cf807ed5c0460b278f9a46953679.png
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simple
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<table><tr><td>Task</td><td>Satisfactory</td><td>Unsatisfactory</td></tr><tr><td>(1) Performs a “time-out” and places monitors on patient (pulse oximetry and NIBP).</td><td>—</td><td>—</td></tr><tr><td>(2) Verifies that spinal kit tray, nonsterile and sterile gloves (correct size), and cleansing solution are present. </td><td>—</td><td>—</td></tr><tr><td>(3) Palpates the superior aspects of the iliac crests and identifies the intersection at the L4 spinous process with nonsterile gloves on. Marks position at the L3/L4 or L4/L5 interspace.</td><td>—</td><td>—</td></tr><tr><td>(4) Cleans the overlying skin with chlorhexidine.</td><td>—</td><td>—</td></tr><tr><td>(5) Opens the spinal tray before placing sterile gloves on.</td><td>—</td><td>—</td></tr><tr><td>(6) Puts on sterile gloves with proper technique.</td><td>—</td><td>—</td></tr><tr><td>(7) Applies sterile drapes.</td><td>—</td><td>—</td></tr><tr><td>(8) Draws up lidocaine in the 3cc syringe and bupivacaine in the 5cc syringe. Administers local anesthesia in a wheal at the previously marked site.</td><td>—</td><td>—</td></tr><tr><td>(9) Injects more anesthetic in the correct location and angle.</td><td>—</td><td>—</td></tr><tr><td>(10) Inserts the introducer needle in the middle of the interspace with a slight cephalad angulation of 10 to 15 degrees. The bevel of the spinal needle should be in the sagittal plane.</td><td>—</td><td>—</td></tr><tr><td>(11) Advances spinal needle through anatomic structures until the subarachnoid space is reached. May experience a popping sensation as the ligamentum flavum is crossed.</td><td>—</td><td>—</td></tr><tr><td>(12) Withdraws the stylet each time a pop is felt to assess for CSF flow.</td><td>—</td><td>—</td></tr><tr><td>(13) Confirms CSF flow by aspiration before and after injecting anesthetic.</td><td>—</td><td>—</td></tr><tr><td>(14) Removes the spinal and introducer needle together once completed. </td><td>—</td><td>—</td></tr><tr><td>(15) Applies pressure with the provided 2 × 2 gauze and assesses good hemostasis.</td><td>—</td><td>—</td></tr><tr><td>(16) Removes the drape, lays the patient, and observes vitals. Disposes of all sharps and biohazard material appropriately. </td><td>—</td><td>—</td></tr></table>
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<table><tr><td>Task</td><td>Satisfactory</td></tr><tr><td>(1) Performs a βtime-outβ and places monitors on patient (pulse oximetry and NIBP).</td><td>β</td></tr><tr><td>(2) Verifies that spinal kit tray, nonsterile and sterile gloves (correct size), and cleansing solution are present.</td><td>β</td></tr><tr><td>(3) Palpates the superior aspects of the iliac crests and identifies the intersection at the L4 spinous process with nonsterile gloves on. Marks position at the L3/L4 or L4/L5 interspace.</td><td>β</td></tr><tr><td>(4) Cleans the overlying skin with chlorhexidine.</td><td>β</td></tr><tr><td>(5) Opens the spinal tray before placing sterile gloves on.</td><td>β</td></tr><tr><td>(6) Puts on sterile gloves with proper technique.</td><td>β</td></tr><tr><td>(7) Applies sterile drapes.</td><td>β</td></tr><tr><td>(8) Draws up lidocaine in the 3cc syringe and bupivacaine in the 5cc syringe. Administers local anesthesia in a wheal at the previously marked site.</td><td>β</td></tr><tr><td>(9) Injects more anesthetic in the correct location and angle.</td><td>β</td></tr><tr><td>(10) Inserts the introducer needle in the middle of the interspace with a slight cephalad angulation of 10 to 15 degrees. The bevel of the spinal needle should be in the sagittal plane.</td><td>β</td></tr><tr><td>(11) Advances spinal needle through anatomic structures until the subarachnoid space is reached. May experience a popping sensation as the ligamentum flavum is crossed.</td><td>β</td></tr><tr><td>(12) Withdraws the stylet each time a pop is felt to assess for CSF flow.</td><td>β</td></tr><tr><td>(13) Confirms CSF flow by aspiration before and after injecting anesthetic.</td><td>β</td></tr><tr><td>(14) Removes the spinal and introducer needle together once completed.</td><td>β</td></tr><tr><td>(15) Applies pressure with the provided 2 Γ 2 gauze and assesses good hemostasis.</td><td>β</td></tr><tr><td>(16) Removes the drape, lays the patient, and observes vitals. Disposes of all sharps and biohazard material appropriately.</td><td>β</td></tr></table>
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<table><tr><td>Unsatisfactory</td></tr><tr><td>β</td></tr><tr><td>β</td></tr><tr><td>β</td></tr><tr><td>β</td></tr><tr><td>β</td></tr><tr><td>β</td></tr><tr><td>β</td></tr><tr><td>β</td></tr><tr><td>β</td></tr><tr><td>β</td></tr><tr><td>β</td></tr><tr><td>β</td></tr><tr><td>β</td></tr><tr><td>β</td></tr><tr><td>β</td></tr><tr><td>β</td></tr></table>
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dd26bb11da1ba9c877a6035d44541a1861c21a8567461c9e9184bf968c9ee64f.png
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complex
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<table><tr><td></td><td></td><td>KEGG pathway</td><td>Count</td><td>P value</td></tr><tr><td rowspan="3">HFF1_24 h vs HFF1</td><td rowspan="3">Up-regulated gene</td><td>hsa04622: RIG-I-like receptor signaling pathway</td><td>6</td><td>9.35E-05</td></tr><tr><td>hsa04620: Toll-like receptor signaling pathway</td><td>5</td><td>0.0043</td></tr><tr><td>hsa04623: Cytosolic DNA-sensing pathway</td><td>4</td><td>0.0057</td></tr><tr><td rowspan="3">HFF1_48 h vs HFF1</td><td rowspan="2">Up-regulated gene</td><td>hsa04620: Toll-like receptor signaling pathway</td><td>6</td><td>0.0209</td></tr><tr><td>hsa04622: RIG-I-like receptor signaling pathway</td><td>5</td><td>0.0249</td></tr><tr><td>Down-regulated gene</td><td>hsa05410: Hypertrophic cardiomyopathy (HCM)</td><td>4</td><td>0.0479</td></tr><tr><td rowspan="6">HFF1_72 h vs HFF1</td><td rowspan="3">Up-regulated gene</td><td>hsa00330: Arginine and proline metabolism</td><td>6</td><td>0.0076</td></tr><tr><td>hsa00480: Glutathione metabolism</td><td>5</td><td>0.0287</td></tr><tr><td>hsa00250: Alanine, aspartate and glutamate metabolism</td><td>4</td><td>0.0349</td></tr><tr><td rowspan="3">Down-regulated gene</td><td>hsa04510: Focal adhesion</td><td>13</td><td>4.57E-05</td></tr><tr><td>hsa04810: Regulation of actin cytoskeleton</td><td>10</td><td>0.0056</td></tr><tr><td>hsa05200: Pathways in cancer</td><td>11</td><td>0.0272</td></tr><tr><td rowspan="8">ES vs HFF1</td><td rowspan="4">Up-regulated gene</td><td>hsa05217: Basal cell carcinoma</td><td>14</td><td>9.58E-06</td></tr><tr><td>hsa04310: Wnt signaling pathway</td><td>22</td><td>1.28E-04</td></tr><tr><td>hsa05200: Pathways in cancer</td><td>36</td><td>2.29E-04</td></tr><tr><td>hsa00330: Arginine and proline metabolism</td><td>10</td><td>0.0029</td></tr><tr><td rowspan="4">Down-regulated gene</td><td>hsa04510: Focal adhesion</td><td>40</td><td>8.73E-08</td></tr><tr><td>hsa00520: Amino sugar and nucleotide sugar metabolism</td><td>13</td><td>1.09E-04</td></tr><tr><td>hsa04512: ECM-receptor interaction</td><td>18</td><td>2.52E-04</td></tr><tr><td>hsa04142: Lysosome</td><td>20</td><td>0.0019</td></tr><tr><td rowspan="8">iPS vs HFF1</td><td rowspan="4">Up-regulated gene</td><td>hsa04310: Wnt signaling pathway</td><td>16</td><td>2.39E-04</td></tr><tr><td>hsa05217: Basal cell carcinoma</td><td>8</td><td>0.0029</td></tr><tr><td>hsa00250: Alanine, aspartate and glutamate metabolism</td><td>6</td><td>0.0041</td></tr><tr><td>hsa00260: Glycine, serine and threonine metabolism</td><td>6</td><td>0.0041</td></tr><tr><td rowspan="4">Down-regulated gene</td><td>hsa04510: Focal adhesion</td><td>56</td><td>1.46E-11</td></tr><tr><td>hsa04512: ECM-receptor interaction</td><td>27</td><td>3.06E-07</td></tr><tr><td>hsa00520: Amino sugar and nucleotide sugar metabolism</td><td>16</td><td>2.84E-05</td></tr><tr><td>hsa04810: Regulation of actin cytoskeleton</td><td>42</td><td>1.43E-04</td></tr></table>
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<table><tr><td></td><td></td><td>KEGG pathway</td><td>Count</td><td>P value</td></tr><tr><td rowspan="3">HFF1_24 h vs HFF1</td><td rowspan="3">Up-regulated gene</td><td>hsa04622: RIG-I-like receptor signaling pathway</td><td>6</td><td>9.35E-05</td></tr><tr><td>hsa04620: Toll-like receptor signaling pathway</td><td>5</td><td>0.0043</td></tr><tr><td>hsa04623: Cytosolic DNA-sensing pathway</td><td>4</td><td>0.0057</td></tr><tr><td rowspan="3">HFF1_48 h vs HFF1</td><td rowspan="2">Up-regulated gene</td><td>hsa04620: Toll-like receptor signaling pathway</td><td>6</td><td>0.0209</td></tr><tr><td>hsa04622: RIG-I-like receptor signaling pathway</td><td>5</td><td>0.0249</td></tr><tr><td>Down-regulated gene</td><td>hsa05410: Hypertrophic cardiomyopathy (HCM)</td><td>4</td><td>0.0479</td></tr><tr><td rowspan="2">HFF1_72 h vs HFF1</td><td rowspan="2">Up-regulated gene</td><td>hsa00330: Arginine and proline metabolism</td><td>6</td><td>0.0076</td></tr><tr><td>hsa00480: Glutathione metabolism</td><td>5</td><td>0.0287</td></tr></table>
|
<table><tr><td rowspan="4">HFF1_72 h vs HFF1</td><td>Up-regulated gene</td><td>hsa00250: Alanine, aspartate and glutamate metabolism</td><td>4</td><td>0.0349</td></tr><tr><td rowspan="3">Down-regulated gene</td><td>hsa04510: Focal adhesion</td><td>13</td><td>4.57E-05</td></tr><tr><td>hsa04810: Regulation of actin cytoskeleton</td><td>10</td><td>0.0056</td></tr><tr><td>hsa05200: Pathways in cancer</td><td>11</td><td>0.0272</td></tr><tr><td rowspan="8">ES vs HFF1</td><td rowspan="4">Up-regulated gene</td><td>hsa05217: Basal cell carcinoma</td><td>14</td><td>9.58E-06</td></tr><tr><td>hsa04310: Wnt signaling pathway</td><td>22</td><td>1.28E-04</td></tr><tr><td>hsa05200: Pathways in cancer</td><td>36</td><td>2.29E-04</td></tr><tr><td>hsa00330: Arginine and proline metabolism</td><td>10</td><td>0.0029</td></tr><tr><td rowspan="4">Down-regulated gene</td><td>hsa04510: Focal adhesion</td><td>40</td><td>8.73E-08</td></tr><tr><td>hsa00520: Amino sugar and nucleotide sugar metabolism</td><td>13</td><td>1.09E-04</td></tr><tr><td>hsa04512: ECM-receptor interaction</td><td>18</td><td>2.52E-04</td></tr><tr><td>hsa04142: Lysosome</td><td>20</td><td>0.0019</td></tr><tr><td rowspan="8">iPS vs HFF1</td><td rowspan="4">Up-regulated gene</td><td>hsa04310: Wnt signaling pathway</td><td>16</td><td>2.39E-04</td></tr><tr><td>hsa05217: Basal cell carcinoma</td><td>8</td><td>0.0029</td></tr><tr><td>hsa00250: Alanine, aspartate and glutamate metabolism</td><td>6</td><td>0.0041</td></tr><tr><td>hsa00260: Glycine, serine and threonine metabolism</td><td>6</td><td>0.0041</td></tr><tr><td rowspan="4">Down-regulated gene</td><td>hsa04510: Focal adhesion</td><td>56</td><td>1.46E-11</td></tr><tr><td>hsa04512: ECM-receptor interaction</td><td>27</td><td>3.06E-07</td></tr><tr><td>hsa00520: Amino sugar and nucleotide sugar metabolism</td><td>16</td><td>2.84E-05</td></tr><tr><td>hsa04810: Regulation of actin cytoskeleton</td><td>42</td><td>1.43E-04</td></tr></table>
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95ef2f5067c76827066ac860bed65e56562bd2ee9c5e10944aef3416bd253def.png
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simple
|
<table><tr><td>Indicator</td><td>0 mg/L</td><td>1 mg/L</td><td>5 mg/L</td><td>10 mg/L</td><td>20 mg/L</td><td>40 mg/L</td><td>80 mg/L</td></tr><tr><td>Spontaneous movements of 36 hpf (bends/30 seconds)</td><td>11.17 ± 2.32</td><td>9.50 ± 1.52</td><td>10.17 ± 1.47</td><td> 8.17 ± 2.79<sup><i>∗∗</i></sup></td><td> 6.83 ± 1.94<sup><i>∗∗</i></sup></td><td> 7.83 ± 1.17<sup><i>∗∗</i></sup></td><td> 9.17 ± 1.17</td></tr><tr><td>Heart rate of 60 hpf (bends/30 seconds)</td><td>67.00 ± 2.45</td><td>64.50 ± 2.88</td><td> 60.67 ± 4.17<sup><i>∗</i></sup></td><td> 64.00 ± 4.24</td><td>75.50 ± 3.27<sup><i>∗∗</i></sup></td><td>70.67 ± 5.74</td><td> 71.00 ± 3.58</td></tr><tr><td>Malformation rate (%)</td><td>5.00 ± 1.00</td><td> 6.67 ± 1.73</td><td> 8.33 ± 1.73</td><td>13.30 ± 1.73<sup><i>∗∗</i></sup></td><td>26.67 ± 4.58<sup><i>∗∗</i></sup></td><td>25.00 ± 3.00<sup><i>∗∗</i></sup></td><td>43.33 ± 4.58<sup><i>∗∗</i></sup></td></tr><tr><td>SV-BA (×10<sup>2</sup> <i>μ</i>m)</td><td>1.90 ± 0.19</td><td> 2.07 ± 0.27</td><td> 2.15 ± 0.28</td><td>2.70 ± 0.45<sup><i>∗∗</i></sup></td><td>3.13 ± 0.26<sup><i>∗∗</i></sup></td><td>3.05 ± 0.47<sup><i>∗∗</i></sup></td><td>3.32 ± 0.26<sup><i>∗∗</i></sup></td></tr><tr><td>Area of pericardial edema (×10<sup>4</sup> <i>μ</i>m<sup>2</sup>)</td><td>2.48 ± 0.53</td><td> 2.60 ± 0.65</td><td> 2.97 ± 0.32</td><td>4.05 ± 0.67<sup><i>∗∗</i></sup></td><td>5.43 ± 0.64<sup><i>∗∗</i></sup></td><td>5.50 ± 0.97<sup><i>∗∗</i></sup></td><td> 5.55 ± 0.75<sup><i>∗∗</i></sup></td></tr><tr><td>Area of sac-yolk edema (×10<sup>5</sup> <i>μ</i>m<sup>2</sup>)</td><td>2.44 ± 0.10</td><td> 2.56 ± 0.10</td><td> 2.42 ± 0.22</td><td>2.83 ± 0.16<sup><i>∗∗</i></sup></td><td>3.17 ± 0.23<sup><i>∗∗</i></sup></td><td>3.49 ± 0.27<sup><i>∗∗</i></sup></td><td> 3.41 ± 0.27<sup><i>∗∗</i></sup></td></tr><tr><td>Body length (mm)</td><td> 3.11 ± 0.21</td><td> 3.13 ± 0.18</td><td> 3.16 ± 0.11</td><td>3.03 ± 0.08</td><td>2.96 ± 0.14</td><td>2.82 ± 0.20<sup><i>∗∗</i></sup></td><td>2.80 ± 0.18<sup><i>∗∗</i></sup></td></tr></table>
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<table><tr><td>Indicator</td><td>0 mg/L</td><td>1 mg/L</td><td>5 mg/L</td><td>10 mg/L</td><td>20 mg/L</td><td>40 mg/L</td><td>80 mg/L</td></tr><tr><td>Spontaneous movements of 36 hpf (bends/30 seconds)</td><td>11.17 Β± 2.32</td><td>9.50 Β± 1.52</td><td>10.17 Β± 1.47</td><td>8.17 Β± 2.79ββ</td><td>6.83 Β± 1.94ββ</td><td>7.83 Β± 1.17ββ</td><td>9.17 Β± 1.17</td></tr><tr><td>Heart rate of 60 hpf (bends/30 seconds)</td><td>67.00 Β± 2.45</td><td>64.50 Β± 2.88</td><td>60.67 Β± 4.17β</td><td>64.00 Β± 4.24</td><td>75.50 Β± 3.27ββ</td><td>70.67 Β± 5.74</td><td>71.00 Β± 3.58</td></tr><tr><td>Malformation rate (%)</td><td>5.00 Β± 1.00</td><td>6.67 Β± 1.73</td><td>8.33 Β± 1.73</td><td>13.30 Β± 1.73ββ</td><td>26.67 Β± 4.58ββ</td><td>25.00 Β± 3.00ββ</td><td>43.33 Β± 4.58ββ</td></tr><tr><td>SV-BA (Γ102 ΞΌm)</td><td>1.90 Β± 0.19</td><td>2.07 Β± 0.27</td><td>2.15 Β± 0.28</td><td>2.70 Β± 0.45ββ</td><td>3.13 Β± 0.26ββ</td><td>3.05 Β± 0.47ββ</td><td>3.32 Β± 0.26ββ</td></tr></table>
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<table><tr><td>Area of pericardial edema (Γ104 ΞΌm2)</td><td>2.48 Β± 0.53</td><td>2.60 Β± 0.65</td><td>2.97 Β± 0.32</td><td>4.05 Β± 0.67ββ</td><td>5.43 Β± 0.64ββ</td><td>5.50 Β± 0.97ββ</td><td>5.55 Β± 0.75ββ</td></tr><tr><td>Area of sac-yolk edema (Γ105 ΞΌm2)</td><td>2.44 Β± 0.10</td><td>2.56 Β± 0.10</td><td>2.42 Β± 0.22</td><td>2.83 Β± 0.16ββ</td><td>3.17 Β± 0.23ββ</td><td>3.49 Β± 0.27ββ</td><td>3.41 Β± 0.27ββ</td></tr><tr><td>Body length (mm)</td><td>3.11 Β± 0.21</td><td>3.13 Β± 0.18</td><td>3.16 Β± 0.11</td><td>3.03 Β± 0.08</td><td>2.96 Β± 0.14</td><td>2.82 Β± 0.20ββ</td><td>2.80 Β± 0.18ββ</td></tr></table>
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072fa098484d6961bdeec74ff090eeddd16337b29be805ea8cad7de2e7b48b26.png
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simple
|
<table><tr><td>Author (reference number)</td><td>Gender</td><td>GA (wks)</td><td>Clinical features of LCH involvement</td><td>Outcome (survival)</td></tr><tr><td>Vade et al. [10]</td><td>F</td><td>35</td><td>Skin, hepatosplenomegaly, pulmonary failure</td><td>Died (9 days)</td></tr><tr><td>Gee et al. [11]</td><td>M</td><td>33</td><td>Skin, pulmonary failure</td><td>Died (36 hrs)</td></tr><tr><td>Aviner et al. [12]</td><td>F</td><td>32</td><td>Skin, followed by multiorgan failure</td><td>Died (26 days)</td></tr><tr><td>Lee et al. [8]</td><td>M</td><td>36</td><td>Hydrops fetalis, skin, multiorgan failure</td><td>Died (12 days)</td></tr><tr><td>Cheng et al. [9]</td><td>M</td><td>33</td><td>Hydrops fetalis, skin, pleural effusion</td><td>Died (36 hrs)</td></tr><tr><td>Herbrüggen et al. [13]</td><td>M</td><td>35</td><td>Skin, at 3 months, pulmonary and thymic mass</td><td>Alive</td></tr><tr><td>Present case</td><td>F</td><td>33</td><td>Skin, hypovolemic shock, pulmonary failure</td><td>Died (57 hrs)</td></tr></table>
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<table><tr><td>Author (reference number)</td><td>Gender</td><td>GA (wks)</td><td>Clinical features of LCH involvement</td><td>Outcome (survival)</td></tr><tr><td>Vade et al. [10]</td><td>F</td><td>35</td><td>Skin, hepatosplenomegaly, pulmonary failure</td><td>Died (9 days)</td></tr><tr><td>Gee et al. [11]</td><td>M</td><td>33</td><td>Skin, pulmonary failure</td><td>Died (36 hrs)</td></tr><tr><td>Aviner et al. [12]</td><td>F</td><td>32</td><td>Skin, followed by multiorgan failure</td><td>Died (26 days)</td></tr><tr><td>Lee </td><td>M</td><td></td><td>Hydrops fetalis, skin, multiorgan fa</td><td>Died </td></tr></table>
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<table><tr><td>et al. [8]</td><td></td><td>36</td><td>ilure</td><td>(12 days)</td></tr><tr><td>Cheng et al. [9]</td><td>M</td><td>33</td><td>Hydrops fetalis, skin, pleural effusion</td><td>Died (36 hrs)</td></tr><tr><td>HerbruΜggen et al. [13]</td><td>M</td><td>35</td><td>Skin, at 3 months, pulmonary and thymic mass</td><td>Alive</td></tr><tr><td>Present case</td><td>F</td><td>33</td><td>Skin, hypovolemic shock, pulmonary failure</td><td>Died (57 hrs)</td></tr></table>
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9aa8cdd069e78620526d8b7565ae1a67eb1a46730636b5c849d3e2411d425f48.png
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complex
|
<table><tr><td></td><td colspan="2">Ontology 8a – Regex</td><td colspan="2">Ontology 7b – Voting</td></tr><tr><td>Total number of top-level terms</td><td>662</td><td></td><td>1886</td><td></td></tr><tr><td>Number of sampled top-level terms</td><td>200</td><td>30.2% of total</td><td>200</td><td>10.6% of total</td></tr><tr><td>Number of sampled top-level terms relevant to animal behaviour</td><td>84</td><td>42% of sample</td><td>82</td><td>41% of sample</td></tr><tr><td>Proportionate number of top- level animal behaviour terms in the whole ontology</td><td>278</td><td></td><td>773</td><td></td></tr><tr><td>Number of sampled top-level an imal behaviour terms not found in the other ontology</td><td>44</td><td>22% of sample</td><td>77</td><td>38.5% of sample</td></tr><tr><td>Proportionate number of top- level animal behaviour terms in the whole ontology not found in the other ontology</td><td>145</td><td></td><td>727</td><td></td></tr></table>
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<table><tr><td></td><td>Ontology 8a β Regex</td></tr><tr><td>Total number of top-level terms</td><td>662</td></tr><tr><td>Number of sampled top-level terms</td><td>200</td></tr><tr><td>Number of sampled top-level terms relevant to animal behaviour</td><td>84</td></tr><tr><td>Proportionate number of top- level animal behaviour terms in the whole ontology</td><td>278</td></tr><tr><td>Number of sampled top-level an imal behaviour terms not found in the other ontology</td><td>44</td></tr><tr><td>Proportionate number of top- level animal behaviour terms in the whole ontology not found in the other ontology</td><td>145</td></tr></table>
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<table><tr><td>Ontology 8a β Regex</td><td colspan="2">Ontology 7b β Voting</td></tr><tr><td></td><td>1886</td><td></td></tr><tr><td>30.2% of total</td><td>200</td><td>10.6% of total</td></tr><tr><td>42% of sample</td><td>82</td><td>41% of sample</td></tr><tr><td></td><td>773</td><td></td></tr><tr><td>22% of sample</td><td>77</td><td>38.5% of sample</td></tr><tr><td></td><td>727</td><td></td></tr></table>
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efc8d3866abf9e379be9716f0a721a1430c5edc5c4ae88b220aa8b1ec814605b.png
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complex
|
<table><tr><td>Parameters</td><td colspan="3">Group</td></tr><tr><td> </td><td>Control diet</td><td>5% CL diet</td><td>10% CL diet</td></tr><tr><td>Food Intake (g/day)</td><td>2.25 ± 0.01</td><td>2.22 ± 0.04</td><td>2.24 ± 0.03</td></tr><tr><td>Initial body weight (g)</td><td>13.9 ± 0.32</td><td>13.7 ± 0.27</td><td>13.7 ± 0.28</td></tr><tr><td>Final body weight (g)</td><td>25.7 ± 0.43</td><td>24.8 ± 0.54</td><td>24.5 ± 0.40</td></tr><tr><td>Liver weight (g/100 g body weight)</td><td>4.50 ± 0.11</td><td>3.88 ± 0.17<sup>*</sup></td><td>3.67 ± 0.12<sup>**</sup></td></tr><tr><td colspan="2">White adipose tissue weight (g/100 g body weight)</td><td> </td><td> </td></tr><tr><td>Total<sup>†</sup></td><td>6.03 ± 0.47</td><td>5.75 ± 0.36</td><td>5.26 ± 0.28</td></tr><tr><td>Abdominal<sup>§</sup></td><td>4.34 ± 0.35</td><td>4.36 ± 0.31</td><td>4.00 ± 0.22</td></tr><tr><td>Epididymal</td><td>2.18 ± 0.16</td><td>2.13 ± 0.16</td><td>1.98 ± 0.11</td></tr><tr><td>Perirenal</td><td>0.81 ± 0.14</td><td>0.80 ± 0.07</td><td>0.64 ± 0.06</td></tr><tr><td>Omental</td><td>1.35 ± 0.08</td><td>1.44 ± 0.10</td><td>1.37 ± 0.08</td></tr><tr><td>Subcutaneous</td><td>1.69 ± 0.12</td><td>1.39 ± 0.06</td><td>1.26 ± 0.08**</td></tr><tr><td>Serum parameters</td><td> </td><td> </td><td> </td></tr><tr><td>Triglyceride (mg/dL)</td><td>35.0 ± 3.41</td><td>40.5 ± 3.71</td><td>32.2 ± 3.10</td></tr><tr><td>Total cholesterol (mg/dL)</td><td>107 ± 4</td><td>107 ± 4</td><td>114 ± 3</td></tr><tr><td>Non-esterified fatty acid (mEq/dL)</td><td>9.68 ± 0.89</td><td>8.41 ± 0.40</td><td>6.56 ± 0.56**</td></tr><tr><td>Glucose (mg/dL)</td><td>210 ± 11</td><td>242 ± 11</td><td>211 ± 25</td></tr><tr><td>Insulin (ng/mL)</td><td>1.70 ± 0.23</td><td>1.74 ± 0.18</td><td>1.79 ± 0.31</td></tr><tr><td>Adiponectin (ng/mL)</td><td>3.58 ± 0.11</td><td>3.51 ± 0.15</td><td>3.30 ± 0.13</td></tr></table>
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<table><tr><td>Parameters</td><td colspan="3">Group</td></tr><tr><td></td><td>Control diet</td><td>5% CL diet</td><td>10% CL diet</td></tr><tr><td>Food Intake (g/day)</td><td>2.25 Β± 0.01</td><td>2.22 Β± 0.04</td><td>2.24 Β± 0.03</td></tr><tr><td>Initial body weight (g)</td><td>13.9 Β± 0.32</td><td>13.7 Β± 0.27</td><td>13.7 Β± 0.28</td></tr><tr><td>Final body weight (g)</td><td>25.7 Β± 0.43</td><td>24.8 Β± 0.54</td><td>24.5 Β± 0.40</td></tr><tr><td>Liver weight (g/100 g body weight)</td><td>4.50 Β± 0.11</td><td>3.88 Β± 0.17*</td><td>3.67 Β± 0.12**</td></tr><tr><td colspan="2">White adipose tissue weight (g/100 g body weight)</td><td></td><td></td></tr><tr><td>Totalβ </td><td>6.03 Β± 0.47</td><td>5.75 Β± 0.36</td><td>5.26 Β± 0.28</td></tr><tr><td>AbdominalΒ§</td><td>4.34 Β± 0.35</td><td>4.36 Β± 0.31</td><td>4.00 Β± 0.22</td></tr><tr><td>Epididymal</td><td>2.18 Β± 0.16</td><td>2.13 Β± 0.16</td><td>1.98 Β± 0.11</td></tr><tr><td>Perirenal</td><td>0.81 Β± 0.14</td><td>0.80 Β± 0.07</td><td>0.64 Β± 0.06</td></tr><tr><td>Omental</td><td>1.35 Β± 0.08</td><td>1.44 Β± 0.10</td><td>1.37 Β± 0.08</td></tr><tr><td>Subcutaneous</td><td>1.69 Β± 0.12</td><td>1.39 Β± 0.06</td><td>1.26 Β± 0.08**</td></tr><tr><td>Serum parameters</td><td></td><td></td><td></td></tr><tr><td>Triglyceride (mg/dL)</td><td>35.0 Β± 3.41</td><td>40.5 Β± 3.71</td><td>32.2 Β± 3.10</td></tr><tr><td>Total cholesterol (mg/dL)</td><td>107 Β± 4</td><td>107 Β± 4</td><td>114 Β± 3</td></tr><tr><td>Non-esterified fatty acid (mEq/dL)</td><td>9.68 Β± 0.89</td><td>8.41 Β± 0.40</td><td>6.56 Β± 0.56**</td></tr><tr><td>Glucose (mg/dL)</td><td>210 Β± 11</td><td>242 Β± 11</td><td>211 Β± 25</td></tr><tr><td>Insul</td><td>1.70 Β± 0</td><td>1.74 Β± </td><td></td></tr></table>
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<table><tr><td>Parameters</td><td colspan="3">Group</td></tr><tr><td></td><td>Control diet</td><td>5% CL diet</td><td>10% CL diet</td></tr><tr><td>in (ng/mL)</td><td>.23</td><td>0.18</td><td>1.79 Β± 0.31</td></tr><tr><td>Adiponectin (ng/mL)</td><td>3.58 Β± 0.11</td><td>3.51 Β± 0.15</td><td>3.30 Β± 0.13</td></tr></table>
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5ac92705479f08eeaae67b2eef317ee38fc12ca99e28aeda058446f3d6eebb21.png
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simple
|
<table><tr><td>Variable</td><td>LBC (M, SD) (<i>n =</i> 1031)</td><td>NLBC (M, SD) (<i>n =</i> 992)</td><td><i>t</i></td><td><i>p</i></td></tr><tr><td>Total</td><td>20.98, 6.273</td><td>21.66, 5.877</td><td>2.498</td><td>0.013</td></tr><tr><td>Gender</td><td></td><td></td><td></td><td></td></tr><tr><td>Male</td><td>20.99, 6.313</td><td>21.56, 5.975</td><td>1.460</td><td>0.145</td></tr><tr><td>Female</td><td>21.05, 6.264</td><td>21.79, 5.772</td><td>1.910</td><td>0.056</td></tr><tr><td>Grade</td><td></td><td></td><td></td><td></td></tr><tr><td>Grade 4</td><td>22.14, 5.623</td><td>22.75, 5.245</td><td>0.907</td><td>0.365</td></tr><tr><td>Grade 5</td><td>22.74, 7.324</td><td>22.50, 6.235</td><td>-0.272</td><td>0.786</td></tr><tr><td>Grade 6</td><td>20.64, 6.467</td><td>21.64, 6.504</td><td>1.400</td><td>0.162</td></tr><tr><td>Grade 7</td><td>20.59, 5.993</td><td>21.51, 5.332</td><td>2.277</td><td>0.023</td></tr><tr><td>Grade 8</td><td>20.43, 5.450</td><td>21.71, 5.246</td><td>2.385</td><td>0.018</td></tr><tr><td>Grade 9</td><td>20.07, 5.990</td><td>20.67, 6.317</td><td>0.968</td><td>0.334</td></tr><tr><td>Educational level</td><td></td><td></td><td></td><td></td></tr><tr><td>Elementary school (grades 4–6)</td><td>21.77, 6.584</td><td>22.23, 6.058</td><td>1.059</td><td>0.290</td></tr><tr><td>Middle school (grades 7–9)</td><td>20.43, 5.992</td><td>21.24, 5.712</td><td>2.380</td><td>0.017</td></tr></table>
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<table><tr><td>Variable</td><td>LBC (M, SD) (n = 1031)</td><td>NLBC (M, SD) (n = 992)</td><td>t</td><td>p</td></tr><tr><td>Total</td><td>20.98, 6.273</td><td>21.66, 5.877</td><td>2.498</td><td>0.013</td></tr><tr><td>Gender</td><td></td><td></td><td></td><td></td></tr><tr><td>Male</td><td>20.99, 6.313</td><td>21.56, 5.975</td><td>1.460</td><td>0.145</td></tr></table>
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<table><tr><td>Variable</td><td>LBC (M, SD) (n = 1031)</td><td>NLBC (M, SD) (n = 992)</td><td>t</td><td>p</td></tr><tr><td>Female</td><td>21.05, 6.264</td><td>21.79, 5.772</td><td>1.910</td><td>0.056</td></tr><tr><td>Grade</td><td></td><td></td><td></td><td></td></tr><tr><td>Grade 4</td><td>22.14, 5.623</td><td>22.75, 5.245</td><td>0.907</td><td>0.365</td></tr><tr><td>Grade 5</td><td>22.74, 7.324</td><td>22.50, 6.235</td><td>-0.272</td><td>0.786</td></tr><tr><td>Grade 6</td><td>20.64, 6.467</td><td>21.64, 6.504</td><td>1.400</td><td>0.162</td></tr><tr><td>Grade 7</td><td>20.59, 5.993</td><td>21.51, 5.332</td><td>2.277</td><td>0.023</td></tr><tr><td>Grade 8</td><td>20.43, 5.450</td><td>21.71, 5.246</td><td>2.385</td><td>0.018</td></tr><tr><td>Grade 9</td><td>20.07, 5.990</td><td>20.67, 6.317</td><td>0.968</td><td>0.334</td></tr><tr><td>Educational level</td><td></td><td></td><td></td><td></td></tr><tr><td>Elementary school (grades 4β6)</td><td>21.77, 6.584</td><td>22.23, 6.058</td><td>1.059</td><td>0.290</td></tr><tr><td>Middle school (grades 7β9)</td><td>20.43, 5.992</td><td>21.24, 5.712</td><td>2.380</td><td>0.017</td></tr></table>
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f4a940e7e9d384944e163f32494f62dcf580973dfab7bd8e51159e67e0664da8.png
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complex
|
<table><tr><td rowspan="2">Variables</td><td>ALL N=383</td><td>Right hemiparesis 208 (54%)</td><td>Left hemiparesis 157 (41%)</td><td>Bilateral hemipareses 18 (5%)</td><td><i>P</i>-Value</td></tr><tr><td colspan="3">mean±SD, n (%)</td></tr><tr><td>Age in years</td><td>54.9±15.3</td><td>58.8±16.4</td><td>57.9±14.8</td><td>47.9±14.7</td><td>0.019</td></tr><tr><td><i>Gender</i></td></tr><tr><td> Male</td><td>213(56)</td><td>124(60)</td><td>82(52)</td><td>7(39)</td><td>0.13</td></tr><tr><td> Female</td><td>170(44)</td><td>84(40)</td><td>75(48)</td><td>11(61)</td></tr><tr><td><i>Discharge disposition</i></td></tr><tr><td> Home</td><td>374(98)</td><td>204(98)</td><td>153(98)</td><td>17(94)</td><td>0.61</td></tr><tr><td> Not to home</td><td>9(2)</td><td>4(2)</td><td>4(2)</td><td>1(6)</td></tr><tr><td>LOS in days</td><td>47.5±28.7</td><td>47.5±32.1</td><td>48.9±28.4</td><td>59.6±37.5</td><td>0.28</td></tr></table>
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<table><tr><td rowspan="2">Variables</td><td>ALL N=383</td><td>Right hemiparesis 208 (54%)</td><td>Left hemiparesis 157 (41%)</td><td>Bilateral hemipareses 18 (5%)</td><td>P-Value</td></tr><tr><td colspan="3">meanΒ±SD, n (%)</td><td colspan="2"></td></tr><tr><td>Age in years</td><td>54.9Β±15.3</td><td>58.8Β±16.4</td><td>57.9Β±14.8</td><td>47.9Β±14.7</td><td>0.019</td></tr><tr><td>Gender</td><td colspan="5"></td></tr><tr><td>Male</td><td>213(56)</td><td>124(60)</td><td>82(52)</td><td>7(39)</td><td>0.13</td></tr><tr><td>Female</td><td>170(44)</td><td>84(40)</td><td>75(48)</td><td>11(61)</td><td rowspan="2"></td></tr><tr><td>Discharge disposition</td><td colspan="4"></td></tr></table>
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<table><tr><td rowspan="2">Variables</td><td>ALL N=383</td><td>Right hemiparesis 208 (54%)</td><td>Left hemiparesis 157 (41%)</td><td>Bilateral hemipareses 18 (5%)</td><td>P-Value</td></tr><tr><td colspan="3">meanΒ±SD, n (%)</td><td colspan="2"></td></tr><tr><td>Home</td><td>374(98)</td><td>204(98)</td><td>153(98)</td><td>17(94)</td><td>0.61</td></tr><tr><td>Not to home</td><td>9(2)</td><td>4(2)</td><td>4(2)</td><td>1(6)</td><td></td></tr><tr><td>LOS in days</td><td>47.5Β±28.7</td><td>47.5Β±32.1</td><td>48.9Β±28.4</td><td>59.6Β±37.5</td><td>0.28</td></tr></table>
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78ff684168e62d338eebbf7e887a49dff1b1ecfab6626b8620f61c7b82b872c3.png
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simple
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<table><tr><td><i>P</i>-Value3</td><td><i>P</i>-Value2</td><td>Control Group</td><td><i>P</i>- Value1</td><td>After Treatment</td><td>Before Treatment</td><td></td></tr><tr><td>0.042**</td><td>0.002*</td><td>72.4±28.4</td><td>0.021*</td><td>58.02±15.33</td><td>51.06±17.77</td><td>TNF-α</td></tr><tr><td>0.07**</td><td>0.002*</td><td>97.54±66.04</td><td>0.056*</td><td>65.67±38.31</td><td>54.66±31.50</td><td>IL-1α</td></tr></table>
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<table><tr><td>P-Value3</td><td>P-Value2</td><td>Control Group</td><td>P- Value1</td><td>After Treatment</td><td>Before Treatment</td><td></td></tr><tr><td>0.042**</td><td>0.002*</td><td>72.4Β±28.4</td><td>0.021*</td><td>58.02Β±15.33</td><td>51.06Β±17.77</td><td>TNF-Ξ±</td></tr><tr><td>0.07*</td><td>0.</td><td></td><td>0.0</td><td>65.67Β±38.</td><td></td><td>I</td></tr></table>
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<table><tr><td>P-Value3</td><td>P-Value2</td><td>Control Group</td><td>P- Value1</td><td>After Treatment</td><td>Before Treatment</td><td></td></tr><tr><td>*</td><td>002*</td><td>97.54Β±66.04</td><td>56*</td><td>31</td><td>54.66Β±31.50</td><td>L-1Ξ±</td></tr></table>
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98baf6ac94a430cef1da20df32dc5c98af547b9c137674d4968ab35fdf87bff1.png
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complex
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<table><tr><td rowspan="2" colspan="2">Test Condition</td><td colspan="4">Filter Medium</td></tr><tr><td>System A</td><td>System B</td><td>System C</td><td>System D</td></tr><tr><td>HLR (m<sup>3</sup>/m<sup>2</sup>/d)</td><td>Inflow (mg/L)</td><td>170.7 ± 61.4</td><td>170.7 ± 61.4</td><td>203.2 ± 51.5</td><td>203.2 ± 51.5</td></tr><tr><td rowspan="2">0.5</td><td>Outflow (mg/L)</td><td>36.5 ± 9.1</td><td>51.1 ± 17.0</td><td>94.6 ± 25.1</td><td>52.8 ± 13.6</td></tr><tr><td>% removal</td><td>76.9 ± 7.3</td><td>68.8 ± 7.5</td><td>54.6 ± 2.7</td><td>73.9 ± 4.1</td></tr><tr><td rowspan="2">1.0</td><td>Outflow (mg/L)</td><td>68.3 ± 29.1</td><td>78.3 ± 24.5</td><td>130.1 ± 32.8</td><td>85.4 ± 17.3</td></tr><tr><td>% removal</td><td>65.2 ± 11.9</td><td>51.8 ± 4.1</td><td>33.9 ± 3.7</td><td>57.0 ± 2.7</td></tr><tr><td rowspan="2">2.0</td><td>Outflow (mg/L)</td><td>78.8 ± 15.6</td><td>110.6 ± 33.5</td><td>152.7 ± 35.4</td><td>111.6 ± 24.5</td></tr><tr><td>% removal</td><td>49.4 ± 14.7</td><td>33.7 ± 4.2</td><td>22.9 ± 3.3</td><td>40.6 ± 6.0</td></tr><tr><td rowspan="2">3.0</td><td>Outflow (mg/L)</td><td>113.3 ± 41.0</td><td>114.8 ± 35.6</td><td>143.9 ± 29.8</td><td>119.5 ± 29.7</td></tr><tr><td>% removal</td><td>30.5 ± 18.2</td><td>33.0 ± 8.6</td><td>26.8 ± 5.0</td><td>42.7 ± 3.1</td></tr></table>
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<table><tr><td colspan="2">Test Condition</td><td colspan="4">Filter Medium</td></tr></table>
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<table><tr><td colspan="2">Test Condition</td><td>System A</td><td>System B</td><td>System C</td><td>System D</td></tr><tr><td>HLR (m3/m2/d)</td><td>Inflow (mg/L)</td><td>170.7 Β± 61.4</td><td>170.7 Β± 61.4</td><td>203.2 Β± 51.5</td><td>203.2 Β± 51.5</td></tr><tr><td rowspan="2">0.5</td><td>Outflow (mg/L)</td><td>36.5 Β± 9.1</td><td>51.1 Β± 17.0</td><td>94.6 Β± 25.1</td><td>52.8 Β± 13.6</td></tr><tr><td>% removal</td><td>76.9 Β± 7.3</td><td>68.8 Β± 7.5</td><td>54.6 Β± 2.7</td><td>73.9 Β± 4.1</td></tr><tr><td rowspan="2">1.0</td><td>Outflow (mg/L)</td><td>68.3 Β± 29.1</td><td>78.3 Β± 24.5</td><td>130.1 Β± 32.8</td><td>85.4 Β± 17.3</td></tr><tr><td>% removal</td><td>65.2 Β± 11.9</td><td>51.8 Β± 4.1</td><td>33.9 Β± 3.7</td><td>57.0 Β± 2.7</td></tr><tr><td rowspan="2">2.0</td><td>Outflow (mg/L)</td><td>78.8 Β± 15.6</td><td>110.6 Β± 33.5</td><td>152.7 Β± 35.4</td><td>111.6 Β± 24.5</td></tr><tr><td>% removal</td><td>49.4 Β± 14.7</td><td>33.7 Β± 4.2</td><td>22.9 Β± 3.3</td><td>40.6 Β± 6.0</td></tr><tr><td rowspan="2">3.0</td><td>Outflow (mg/L)</td><td>113.3 Β± 41.0</td><td>114.8 Β± 35.6</td><td>143.9 Β± 29.8</td><td>119.5 Β± 29.7</td></tr><tr><td>% removal</td><td>30.5 Β± 18.2</td><td>33.0 Β± 8.6</td><td>26.8 Β± 5.0</td><td>42.7 Β± 3.1</td></tr></table>
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ba6da193bc93d80daae9066898589d5a20f8ffde24368bbfc7357b8a98816a5a.png
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complex
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<table><tr><td rowspan="3"></td><td>Super-obese group</td><td>Comparison</td><td rowspan="3">OR</td><td rowspan="3">AOR<sup>b</sup></td></tr><tr><td>(<i>N</i> = 370)</td><td>(<i>N</i> = 621)</td></tr><tr><td>%</td><td>%</td></tr><tr><td colspan="5">Complications during pregnancy</td></tr><tr><td> Medical problems during pregnancy</td><td>33.3</td><td>13</td><td>3.35 (2.43–4.62)</td><td>2.89 (2.64–4.11)</td></tr><tr><td> Obstetric problems during pregnancy</td><td>42</td><td>23.2</td><td>2.40 (1.81–3.17)</td><td>2.42 (1.77–3.29)</td></tr><tr><td> Gestational diabetes</td><td>15.6</td><td>7.2</td><td>2.36 (1.56–3.59)</td><td>2.52 (1.58–4.65)</td></tr><tr><td> Gestational hypertension</td><td>12.3</td><td>1.5</td><td>9.33 (4.50–19.33)</td><td>10.24 (4.67–22.44)</td></tr><tr><td> Preeclampsia</td><td>8.5</td><td>2.6</td><td>3.42 (1.85–6.35)</td><td>3.43 (1.72–6.84)</td></tr><tr><td colspan="5">Obstetric</td></tr><tr><td> Labour</td><td>65.8</td><td>77.6</td><td>0.55 (0.42–0.74)</td><td>0.49 (0.35–0.68)</td></tr><tr><td> Induction of labour</td><td>58.3</td><td>26.9</td><td>3.81 (2.75–5.28)</td><td>4.33 (3.21–6.24)</td></tr><tr><td> Caesarean section</td><td>52</td><td>31.7</td><td>2.33 (1.79–3.65)</td><td>2.73 (2.02–3.69)</td></tr><tr><td colspan="5">Perinatal outcomes (singletons only)</td></tr><tr><td> Birthweight ≥4500 g</td><td>10.1</td><td>0.8</td><td>13.44 (5.22–34.57)</td><td>19.94 (6.81–58.36)</td></tr><tr><td> Admitted to NICU</td><td>23.7</td><td>13.9</td><td>1.93 (1.38–2.71)</td><td>1.83 (1.27–2.65)</td></tr><tr><td> Need for transfer</td><td>8.5</td><td>2.7</td><td>3.39 (1.82–6.31)</td><td>3.81 (1.93–7.55)</td></tr><tr><td> Preterm birth <37 weeks</td><td>10.1</td><td>8.1</td><td>1.28 (0.81–2.00)</td><td>1.18 (0.72,1.93)</td></tr><tr><td colspan="5">Maternal outcomes</td></tr><tr><td> Admission to ICU</td><td>2.2</td><td>0.5</td><td>4.56 (1.25–17.32)</td><td>7.38 (1.52–35.87)</td></tr><tr><td> Admission to HDU</td><td>4.3</td><td>0.8</td><td>5.58 (2.43–15.37)</td><td>5.40 (1.78–16.38)</td></tr><tr><td> Admission to either ICU or HDU</td><td>6.2</td><td>1.3</td><td>5.09 (2.25–11.51)</td><td>5.67 (2.31–13.93)</td></tr></table>
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<table><tr><td rowspan="3"></td><td>Super-obese group</td><td>Comparison</td><td rowspan="3">OR</td><td rowspan="3">AORb</td></tr><tr><td>(N = 370)</td><td>(N = 621)</td></tr><tr><td>%</td><td>%</td></tr><tr><td colspan="5">Complications during pregnancy</td></tr><tr><td>Me</td><td></td><td>13</td><td>3.35 (2.43β4.62</td><td>2.89</td></tr></table>
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<table><tr><td rowspan="3"></td><td>Super-obese group</td><td>Comparison</td><td rowspan="3">OR</td><td rowspan="3">AORb</td></tr><tr><td>(N = 370)</td><td>(N = 621)</td></tr><tr><td>%</td><td>%</td></tr><tr><td>dical problems during pregnancy</td><td>33.3</td><td></td><td>)</td><td> (2.64β4.11)</td></tr><tr><td>Obstetric problems during pregnancy</td><td>42</td><td>23.2</td><td>2.40 (1.81β3.17)</td><td>2.42 (1.77β3.29)</td></tr><tr><td>Gestational diabetes</td><td>15.6</td><td>7.2</td><td>2.36 (1.56β3.59)</td><td>2.52 (1.58β4.65)</td></tr><tr><td>Gestational hypertension</td><td>12.3</td><td>1.5</td><td>9.33 (4.50β19.33)</td><td>10.24 (4.67β22.44)</td></tr><tr><td>Preeclampsia</td><td>8.5</td><td>2.6</td><td>3.42 (1.85β6.35)</td><td>3.43 (1.72β6.84)</td></tr><tr><td colspan="5">Obstetric</td></tr><tr><td>Labour</td><td>65.8</td><td>77.6</td><td>0.55 (0.42β0.74)</td><td>0.49 (0.35β0.68)</td></tr><tr><td>Induction of labour</td><td>58.3</td><td>26.9</td><td>3.81 (2.75β5.28)</td><td>4.33 (3.21β6.24)</td></tr><tr><td>Caesarean section</td><td>52</td><td>31.7</td><td>2.33 (1.79β3.65)</td><td>2.73 (2.02β3.69)</td></tr><tr><td colspan="5">Perinatal outcomes (singletons only)</td></tr><tr><td>Birthweight β₯4500 g</td><td>10.1</td><td>0.8</td><td>13.44 (5.22β34.57)</td><td>19.94 (6.81β58.36)</td></tr><tr><td>Admitted to NICU</td><td>23.7</td><td>13.9</td><td>1.93 (1.38β2.71)</td><td>1.83 (1.27β2.65)</td></tr><tr><td>Need for transfer</td><td>8.5</td><td>2.7</td><td>3.39 (1.82β6.31)</td><td>3.81 (1.93β7.55)</td></tr><tr><td>Preterm birth <37 weeks</td><td>10.1</td><td>8.1</td><td>1.28 (0.81β2.00)</td><td>1.18 (0.72,1.93)</td></tr><tr><td colspan="5">Maternal outcomes</td></tr><tr><td>Admission to ICU</td><td>2.2</td><td>0.5</td><td>4.56 (1.25β17.32)</td><td>7.38 (1.52β35.87)</td></tr><tr><td>Admission to HDU</td><td>4.3</td><td>0.8</td><td>5.58 (2.43β15.37)</td><td>5.40 (1.78β16.38)</td></tr><tr><td>Admission to either ICU or HDU</td><td>6.2</td><td>1.3</td><td>5.09 (2.25β11.51)</td><td>5.67 (2.31β13.93)</td></tr></table>
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75e6267aa200cdbd6402da92dcb5c9f2e40363f63c13c293ab6da7762b8d3ae9.png
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simple
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<table><tr><td>Composites</td><td>Relatives items</td></tr><tr><td>Parental sensitivity</td><td>Acknowledging; imitating; elaborating; parent gaze; positive affect; vocal appropriateness, clarity; appropriate range of affect; resourcefulness; praising; affectionate touch; supportive presence; infant led interaction</td></tr><tr><td>Parent intrusiveness</td><td>Forcing-physical manipulation; overriding, intrusiveness; parent negative affect, anger; parent anxiety; criticizing; parent-led interaction</td></tr><tr><td>Parent limit setting</td><td>Consistency of style; resourcefulness; appropriate structure, limit setting</td></tr><tr><td>Child compliance</td><td>Compliance to parent; reliance on parent for help; on-task persistence</td></tr><tr><td>Child withdrawal</td><td>Child negative emotionality, fussy; withdrawal; labile affect; avoidance of parent</td></tr><tr><td>Child engagement</td><td>Joint attention; child positive affect; affection to parent; alertness; fatigue; vocalizations, verbal output; initiation; competent use of the environment; creative-symbolic play; infant-led interaction</td></tr><tr><td>Dyadic joint negative state</td><td>Parent negative affect, anger; hostility; child negative emotionality, fussy; withdrawal, labile affect; fatigue; constriction; tension</td></tr><tr><td>Dyadic reciprocity</td><td>Parent gaze; positive affect; praising; affectionate touch; joint attention; child positive affect; vocalization, verbal output; initiation; dyadic reciprocity; adaptation-regulation; fluency</td></tr></table>
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<table><tr><td>Composites</td><td>Relatives items</td></tr><tr><td>Parental sensitivity</td><td>Acknowledging; imitating; elaborating; parent gaze; positive affect; vocal appropriateness, clarity; appropriate range of affect; resourcefulness; praising; affectionate touch; supportive presence; infant led interaction</td></tr><tr><td>Parent intrusiveness</td><td>Forcing-physical manipulation; overriding, intrusiveness; parent negative affect, anger; parent anxiety; criticizing; parent-led interaction</td></tr><tr><td>Parent limit setting</td><td>Consistency of style; resourcefulness; appropriate structure, limit setting</td></tr><tr><td>Child compliance</td><td>Compliance to parent; reliance on parent for help; on-task persistence</td></tr><tr><td>Child withdrawal</td><td>Child negative emotionality, fussy; withdrawal; labile affect; avoidance of parent</td></tr></table>
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<table><tr><td>Composites</td><td>Relatives items</td></tr><tr><td>Child engagement</td><td>Joint attention; child positive affect; affection to parent; alertness; fatigue; vocalizations, verbal output; initiation; competent use of the environment; creative-symbolic play; infant-led interaction</td></tr><tr><td>Dyadic joint negative state</td><td>Parent negative affect, anger; hostility; child negative emotionality, fussy; withdrawal, labile affect; fatigue; constriction; tension</td></tr><tr><td>Dyadic reciprocity</td><td>Parent gaze; positive affect; praising; affectionate touch; joint attention; child positive affect; vocalization, verbal output; initiation; dyadic reciprocity; adaptation-regulation; fluency</td></tr></table>
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a50e721275aae76d4e8d370d422a0b596980d401e6aa93cdf8cf245c9af3188e.png
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complex
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<table><tr><td colspan="3">PRISMA statement results</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td></td><td colspan="2">Yes</td><td colspan="2">Partial</td><td colspan="2">No</td></tr><tr><td>Title</td><td>1</td><td>Title</td><td>221</td><td>(93%)</td><td>13</td><td>(5%)</td><td>2</td><td>(0%)</td></tr><tr><td>Abstract</td><td>2</td><td>Structured summary</td><td>82</td><td>(35%)</td><td>147</td><td>(62%)</td><td>7</td><td>(3%)</td></tr><tr><td>Introduction</td><td>3</td><td>Rationale</td><td>233</td><td>(98%)</td><td>3</td><td>(1%)</td><td>0</td><td>(0%)</td></tr><tr><td>Methods</td><td>4</td><td>Objectives</td><td>143</td><td>(60%)</td><td>90</td><td>(38%)</td><td>3</td><td>(1%)</td></tr><tr><td></td><td>5</td><td>Protocol and registration</td><td>2</td><td>(1%)</td><td>35</td><td>(15%)</td><td>199</td><td>(84%)</td></tr><tr><td></td><td>6</td><td>Eligibility criteria</td><td>209</td><td>(88%)</td><td>27</td><td>(11%)</td><td>0</td><td>(0%)</td></tr><tr><td></td><td>7</td><td>Information sources</td><td>235</td><td>(99%)</td><td>1</td><td>(0%)</td><td>0</td><td>(0%)</td></tr><tr><td></td><td>8</td><td>Search</td><td>59</td><td>(25%)</td><td>177</td><td>(75%)</td><td>0</td><td>(0%)</td></tr><tr><td></td><td>9</td><td>Study selection</td><td>134</td><td>(57%)</td><td>30</td><td>(13%)</td><td>72</td><td>(30%)</td></tr><tr><td></td><td>10</td><td>Data collection process</td><td>149</td><td>(63%)</td><td>16</td><td>(7%)</td><td>71</td><td>(30%)</td></tr><tr><td></td><td>11</td><td>Data items</td><td>127</td><td>(54%)</td><td>64</td><td>(27%)</td><td>45</td><td>(19%)</td></tr><tr><td></td><td>12</td><td>Risk of bias in individual studies</td><td>103</td><td>(43%)</td><td>79</td><td>(33%)</td><td>54</td><td>(23%)</td></tr><tr><td></td><td>13</td><td>Summary measures</td><td>235</td><td>(99%)</td><td>0</td><td>(0%)</td><td>1</td><td>(0%)</td></tr><tr><td></td><td>14</td><td>Synthesis of results</td><td>234</td><td>(99%)</td><td>2</td><td>(1%)</td><td>0</td><td>(0%)</td></tr><tr><td></td><td>15</td><td>Risk of bias across studies</td><td>152</td><td>(64%)</td><td>30</td><td>(13%)</td><td>54</td><td>(23%)</td></tr><tr><td></td><td>16</td><td>Additional analyses</td><td>101</td><td>(43%)</td><td>12</td><td>(5%)</td><td>123</td><td>(52%)</td></tr><tr><td>Results</td><td>17</td><td>Study selection</td><td>112</td><td>(47%)</td><td>91</td><td>(38%)</td><td>33</td><td>(14%)</td></tr><tr><td></td><td>18</td><td>Study characteristics</td><td>132</td><td>(56%)</td><td>94</td><td>(40%)</td><td>10</td><td>(4%)</td></tr><tr><td></td><td>19</td><td>Risk of bias within studies</td><td>76</td><td>(32%)</td><td>84</td><td>(36%)</td><td>76</td><td>(32%)</td></tr><tr><td></td><td>20</td><td>Results of individual studies</td><td>162</td><td>(68%)</td><td>36</td><td>(15%)</td><td>39</td><td>(16%)</td></tr><tr><td></td><td>21</td><td>Synthesis of results</td><td>235</td><td>(99%)</td><td>1</td><td>(0%)</td><td>0</td><td>(0%)</td></tr><tr><td></td><td>22</td><td>Risk of bias across studies</td><td>136</td><td>(57%)</td><td>35</td><td>(15%)</td><td>65</td><td>(27%)</td></tr><tr><td></td><td>23</td><td>Additional analyses</td><td>90</td><td>(38%)</td><td>24</td><td>(10%)</td><td>122</td><td>(51%)</td></tr><tr><td>Discussion</td><td>24</td><td>Summary of evidence</td><td>232</td><td>(98%)</td><td>4</td><td>(2%)</td><td>0</td><td>(0%)</td></tr><tr><td></td><td>25</td><td>Limitations</td><td>139</td><td>(59%)</td><td>38</td><td>(16%)</td><td>59</td><td>(25%)</td></tr><tr><td></td><td>26</td><td>Conclusions</td><td>232</td><td>(98%)</td><td>4</td><td>(2%)</td><td>0</td><td>(0%)</td></tr><tr><td>Funding</td><td>27</td><td>Funding</td><td>114</td><td>(48%)</td><td>0</td><td>(0%)</td><td>122</td><td>(51%)</td></tr></table>
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<table><tr><td colspan="3">PRISMA statement results</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td></td><td colspan="2">Yes</td><td colspan="2">Partial</td><td colspan="2">No</td></tr><tr><td>Title</td><td>1</td><td>Title</td><td>221</td><td>(93%)</td><td>13</td><td>(5%)</td><td>2</td><td>(0%)</td></tr><tr><td>Abstract</td><td>2</td><td>Structured summary</td><td>82</td><td>(35%)</td><td>147</td><td>(62%)</td><td>7</td><td>(3%)</td></tr><tr><td>Introduction</td><td>3</td><td>Rationale</td><td>233</td><td>(98%)</td><td>3</td><td>(1%)</td><td>0</td><td>(0%)</td></tr><tr><td>Methods</td><td>4</td><td>Objectives</td><td>143</td><td>(60%)</td><td>90</td><td>(38%)</td><td>3</td><td>(1%)</td></tr><tr><td></td><td>5</td><td>Protocol and registration</td><td>2</td><td>(1%)</td><td>35</td><td>(15%)</td><td>199</td><td>(84%)</td></tr><tr><td></td><td>6</td><td>Eligibility criteria</td><td>209</td><td>(88%)</td><td>27</td><td>(11%)</td><td>0</td><td>(0%)</td></tr><tr><td></td><td>7</td><td>Information sources</td><td>235</td><td>(99%)</td><td>1</td><td>(0%)</td><td>0</td><td>(0%)</td></tr><tr><td></td><td></td><td>Se</td><td>59</td><td>(25%</td><td>177</td><td>(75%)</td><td>0</td><td>(0</td></tr></table>
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<table><tr><td></td><td>8</td><td>arch</td><td></td><td>)</td><td></td><td></td><td></td><td>%)</td></tr><tr><td></td><td>9</td><td>Study selection</td><td>134</td><td>(57%)</td><td>30</td><td>(13%)</td><td>72</td><td>(30%)</td></tr><tr><td></td><td>10</td><td>Data collection process</td><td>149</td><td>(63%)</td><td>16</td><td>(7%)</td><td>71</td><td>(30%)</td></tr><tr><td></td><td>11</td><td>Data items</td><td>127</td><td>(54%)</td><td>64</td><td>(27%)</td><td>45</td><td>(19%)</td></tr><tr><td></td><td>12</td><td>Risk of bias in individual studies</td><td>103</td><td>(43%)</td><td>79</td><td>(33%)</td><td>54</td><td>(23%)</td></tr><tr><td></td><td>13</td><td>Summary measures</td><td>235</td><td>(99%)</td><td>0</td><td>(0%)</td><td>1</td><td>(0%)</td></tr><tr><td></td><td>14</td><td>Synthesis of results</td><td>234</td><td>(99%)</td><td>2</td><td>(1%)</td><td>0</td><td>(0%)</td></tr><tr><td></td><td>15</td><td>Risk of bias across studies</td><td>152</td><td>(64%)</td><td>30</td><td>(13%)</td><td>54</td><td>(23%)</td></tr><tr><td></td><td>16</td><td>Additional analyses</td><td>101</td><td>(43%)</td><td>12</td><td>(5%)</td><td>123</td><td>(52%)</td></tr><tr><td>Results</td><td>17</td><td>Study selection</td><td>112</td><td>(47%)</td><td>91</td><td>(38%)</td><td>33</td><td>(14%)</td></tr><tr><td></td><td>18</td><td>Study characteristics</td><td>132</td><td>(56%)</td><td>94</td><td>(40%)</td><td>10</td><td>(4%)</td></tr><tr><td></td><td>19</td><td>Risk of bias within studies</td><td>76</td><td>(32%)</td><td>84</td><td>(36%)</td><td>76</td><td>(32%)</td></tr><tr><td></td><td>20</td><td>Results of individual studies</td><td>162</td><td>(68%)</td><td>36</td><td>(15%)</td><td>39</td><td>(16%)</td></tr><tr><td></td><td>21</td><td>Synthesis of results</td><td>235</td><td>(99%)</td><td>1</td><td>(0%)</td><td>0</td><td>(0%)</td></tr><tr><td></td><td>22</td><td>Risk of bias across studies</td><td>136</td><td>(57%)</td><td>35</td><td>(15%)</td><td>65</td><td>(27%)</td></tr><tr><td></td><td>23</td><td>Additional analyses</td><td>90</td><td>(38%)</td><td>24</td><td>(10%)</td><td>122</td><td>(51%)</td></tr><tr><td>Discussion</td><td>24</td><td>Summary of evidence</td><td>232</td><td>(98%)</td><td>4</td><td>(2%)</td><td>0</td><td>(0%)</td></tr><tr><td></td><td>25</td><td>Limitations</td><td>139</td><td>(59%)</td><td>38</td><td>(16%)</td><td>59</td><td>(25%)</td></tr><tr><td></td><td>26</td><td>Conclusions</td><td>232</td><td>(98%)</td><td>4</td><td>(2%)</td><td>0</td><td>(0%)</td></tr><tr><td>Funding</td><td>27</td><td>Funding</td><td>114</td><td>(48%)</td><td>0</td><td>(0%)</td><td>122</td><td>(51%)</td></tr></table>
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d70ab01a7cee882fa47791016870a64d2797a2c33e28deca99c7971896196a07.png
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simple
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<table><tr><td>Patients with total lipid profile</td><td>CVD + DM (n = 753)</td><td>CVD (w/o DM) (n = 280)</td><td>DM (w/o CVD) (n = 586)</td><td>SCORE ≥ 10% (n = 30)</td></tr><tr><td>LDL-C ≥ 1.8 mmol/L and LDL-reduction <50% [%]</td><td>74.4</td><td>63.9</td><td>65.4</td><td>80.0</td></tr><tr><td>Low HDL-C (<1.0 [men]/1.2 [women] mmol/L) [%]</td><td>68.4</td><td>52.9</td><td>48.3</td><td>56.7</td></tr><tr><td>Elevated TG (>1.7 mmol/L) [%]</td><td>65.1</td><td>38.2</td><td>39.1</td><td>53.3</td></tr><tr><td>All patients</td><td>(n = 829)</td><td>(n = 312)</td><td>(n = 629)</td><td>(n= 30)</td></tr><tr><td>LDL-C ≥ 1.8 mmol/L and LDL-reduction <50% [%]*</td><td>74.4</td><td>63.9</td><td>65.4</td><td>80.0</td></tr><tr><td>Low HDL-C (<1.0 [men]/1.2 [women] mmol/L) [%]†‡</td><td>69.4</td><td>54.8</td><td>50.0</td><td>56.7</td></tr><tr><td>Elevated TG (>1.7 mmol/L) [%]‡</td><td>61.1</td><td>35.3</td><td>38.7</td><td>53.3</td></tr></table>
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<table><tr><td>Patients with total lipid profile</td><td>CVD + DM (n = 753)</td><td>CVD (w/o DM) (n = 280)</td><td>DM (w/o CVD) (n = 586)</td><td>SCORE β₯ 10% (n = 30)</td></tr><tr><td>LDL-C β₯ 1.8 mmol/L and LDL-reduction <50% [%]</td><td>74.4</td><td>63.9</td><td>65.4</td><td>80.0</td></tr><tr><td>Low HDL-C (<1.0 [men]/1.2 [women] mmol/L) [%]</td><td>68.4</td><td>52.9</td><td>48.3</td><td>56.7</td></tr><tr><td>Elevated TG (>1.7 mmol/L) [%]</td><td>65.1</td><td>38.2</td><td>39.1</td><td>53.3</td></tr></table>
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<table><tr><td>Patients with total lipid profile</td><td>CVD + DM (n = 753)</td><td>CVD (w/o DM) (n = 280)</td><td>DM (w/o CVD) (n = 586)</td><td>SCORE β₯ 10% (n = 30)</td></tr><tr><td>All patients</td><td>(n = 829)</td><td>(n = 312)</td><td>(n = 629)</td><td>(n= 30)</td></tr><tr><td>LDL-C β₯ 1.8 mmol/L and LDL-reduction <50% [%]*</td><td>74.4</td><td>63.9</td><td>65.4</td><td>80.0</td></tr><tr><td>Low HDL-C (<1.0 [men]/1.2 [women] mmol/L) [%]β β‘</td><td>69.4</td><td>54.8</td><td>50.0</td><td>56.7</td></tr><tr><td>Elevated TG (>1.7 mmol/L) [%]β‘</td><td>61.1</td><td>35.3</td><td>38.7</td><td>53.3</td></tr></table>
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468f1f07b1d5df8475c46466212a0c2d4eedd729d8738718589bdeecd42c5893.png
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simple
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<table><tr><td></td><td></td><td>NorthernTanna(n = 364)</td><td>Northern TannaHighlands(n = 515)</td><td>Southern Tanna(n = 370)</td><td>Aneityum(n = 517)</td><td>Total(n = 1766)</td></tr><tr><td></td><td>Male</td><td>47.3 (172)</td><td>48.1 (245)</td><td>50.3 (186)</td><td>48.6 (251)</td><td>48.5 (854)</td></tr><tr><td>Sex</td><td>Female</td><td>52.8 (192)</td><td>51.9 (264)</td><td>49.7 (184)</td><td>51.5 (266)</td><td>51.5 (906)</td></tr><tr><td></td><td>Not recorded</td><td>0</td><td>6</td><td>0</td><td>0</td><td>6</td></tr><tr><td></td><td>0-5</td><td>18.4 (67)</td><td>23.1 (119)</td><td>14.1 (52)</td><td>17.4 (90)</td><td>18.6 (328)</td></tr><tr><td></td><td>5-20</td><td>48.4 (176)</td><td>42.9 (221)</td><td>52.7 (195)</td><td>42.4 (219)</td><td>45.9 (811)</td></tr><tr><td>Age (Years)</td><td>20-80</td><td>33.2 (121)</td><td>34.0 (175)</td><td>33.2 (123)</td><td>40.2 (208)</td><td>35.5 (627)</td></tr><tr><td></td><td>Total</td><td>100 (364)</td><td>100 (515)</td><td>100 (370)</td><td>100 (517)</td><td>100 (1766)</td></tr><tr><td></td><td>No</td><td>21.8 (79)</td><td>61.7 (269)</td><td>11.1 (41)</td><td>10.1 (52)</td><td>26.1 (441)</td></tr><tr><td>Used a bed net the night before the survey</td><td>Yes</td><td>78.2 (284)</td><td>38.3 (167)</td><td>88.9 (329)</td><td>89.9 (465)</td><td>73.8(1245)</td></tr><tr><td></td><td>Not recorded</td><td>1</td><td>79</td><td>0</td><td>0</td><td>80</td></tr></table>
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<table><tr><td></td><td></td><td>NorthernTanna(n = 364)</td><td>Northern TannaHighlands(n = 515)</td><td>Southern Tanna(n = 370)</td><td>Aneityum(n = 517)</td><td>Total(n = 1766)</td></tr><tr><td></td><td>Male</td><td>47.3 (172)</td><td>48.1 (245)</td><td>50.3 (186)</td><td>48.6 (251)</td><td>48.5 (854)</td></tr><tr><td>Sex</td><td>Female</td><td>52.8 (192)</td><td>51.9 (264)</td><td>49.7 (184)</td><td>51.5 (266)</td><td>51.5 (906)</td></tr><tr><td></td><td>Not recorded</td><td>0</td><td>6</td><td>0</td><td>0</td><td>6</td></tr><tr><td></td><td>0-5</td><td>18.4 (67)</td><td>23.1 (119)</td><td>14.1 (52)</td><td>17.4 (90)</td><td>18.6 (328)</td></tr><tr><td></td><td>5-20</td><td>48.4 (176)</td><td>42.9 (221)</td><td>52.7 (195)</td><td>42.4 (219)</td><td>45.9 (811)</td></tr><tr><td>Age (Years)</td><td>20-80</td><td>33.2 (121)</td><td>34.0 (175)</td><td>33.2 (123)</td><td>40.2 (208)</td><td>35.5 (627)</td></tr><tr><td></td><td>Total</td><td>100 (364)</td><td>100 (515)</td><td>100 (370)</td><td>100 (517)</td><td>100 (1766)</td></tr></table>
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<table><tr><td></td><td></td><td>NorthernTanna(n = 364)</td><td>Northern TannaHighlands(n = 515)</td><td>Southern Tanna(n = 370)</td><td>Aneityum(n = 517)</td><td>Total(n = 1766)</td></tr><tr><td></td><td>No</td><td>21.8 (79)</td><td>61.7 (269)</td><td>11.1 (41)</td><td>10.1 (52)</td><td>26.1 (441)</td></tr><tr><td>Used a bed net the night before the survey</td><td>Yes</td><td>78.2 (284)</td><td>38.3 (167)</td><td>88.9 (329)</td><td>89.9 (465)</td><td>73.8(1245)</td></tr><tr><td></td><td>Not recorded</td><td>1</td><td>79</td><td>0</td><td>0</td><td>80</td></tr></table>
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c9d9ac59878865d43e3cadd8398563607ed6bbb23da627a884ff2c7944ce2e50.png
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complex
|
<table><tr><td rowspan="2">Difference</td><td colspan="2">PSF + TOF vs. PSF</td><td colspan="2">3D-OSEM + TOF vs. 3D-OSEM</td></tr><tr><td>Low TBR</td><td>High TBR</td><td>Low TBR</td><td>High TBR</td></tr><tr><td></td><td>**</td><td>n.s.</td><td>**</td><td>n.s.</td></tr><tr><td>Median</td><td>10.4</td><td>1.8</td><td>8.6</td><td>−0.1</td></tr><tr><td>IQR</td><td>3.1 to 19.0</td><td>−0.8 to 5.5</td><td>3.3 to 14.8</td><td>−6.0 to 2.4</td></tr><tr><td>Range</td><td>1.0 to 27.2</td><td>−16.7 to 27.9</td><td>−5.9 to 17.5</td><td>−13.9 to 24.0</td></tr></table>
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<table><tr><td rowspan="2">Difference</td><td colspan="2">PSF + TOF vs. PSF</td><td colspan="2">3D-OSEM + TOF vs. 3D-OSEM</td></tr><tr><td>Low TBR</td><td>High TBR</td><td>Low TBR</td><td>High TBR</td></tr><tr><td></td><td>**</td><td>n.s.</td><td>**</td><td>n.s.</td></tr></table>
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<table><tr><td>Median</td><td>10.4</td><td>1.8</td><td>8.6</td><td>β0.1</td></tr><tr><td>IQR</td><td>3.1 to 19.0</td><td>β0.8 to 5.5</td><td>3.3 to 14.8</td><td>β6.0 to 2.4</td></tr><tr><td>Range</td><td>1.0 to 27.2</td><td>β16.7 to 27.9</td><td>β5.9 to 17.5</td><td>β13.9 to 24.0</td></tr></table>
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d5ebc7bfdcc301dab5bfc94681a01d0054799d39eda700f93cef47b36f1192d4.png
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simple
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<table><tr><td>Cell line</td><td>Gq mutant</td><td>G11 mutant</td><td>BRAF mutant</td></tr><tr><td>Melanocytes</td><td>WT</td><td>WT</td><td>WT</td></tr><tr><td>OCM1</td><td>WT</td><td>WT</td><td>V600E</td></tr><tr><td>OCM3</td><td>WT</td><td>WT</td><td>V600E</td></tr><tr><td>OMM1</td><td>WT</td><td>Q209L</td><td>WT</td></tr><tr><td>OMM2.3*</td><td>Q209P</td><td>WT</td><td>WT</td></tr><tr><td>Mel270*</td><td>Q209P</td><td>WT</td><td>WT</td></tr><tr><td>LOXIMVI</td><td>WT</td><td>WT</td><td>V600E</td></tr><tr><td>M14</td><td>WT</td><td>WT</td><td>V600E</td></tr><tr><td>MALME-3M</td><td>WT</td><td>WT</td><td>V600E</td></tr><tr><td>MDA-MB-435</td><td>WT</td><td>WT</td><td>V600E</td></tr><tr><td>SK-MEL-2</td><td>WT</td><td>WT</td><td>V600E</td></tr><tr><td>SK-MEL-28</td><td>WT</td><td>WT</td><td>V600E</td></tr><tr><td>SK-MEL-5</td><td>WT</td><td>WT</td><td>V600E</td></tr><tr><td>ACC-257</td><td>WT</td><td>WT</td><td>V600E</td></tr><tr><td>UACC-62</td><td>WT</td><td>WT</td><td>V600E</td></tr></table>
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<table><tr><td>Cell line</td><td>Gq mutant</td><td>G11 mutant</td></tr><tr><td>Melanocytes</td><td>WT</td><td>WT</td></tr><tr><td>OCM1</td><td>WT</td><td>WT</td></tr><tr><td>OCM3</td><td>WT</td><td>WT</td></tr><tr><td>OMM1</td><td>WT</td><td>Q209L</td></tr><tr><td>OMM2.3*</td><td>Q209P</td><td>WT</td></tr><tr><td>Mel270*</td><td>Q209P</td><td>WT</td></tr><tr><td>LOXIMVI</td><td>WT</td><td>WT</td></tr><tr><td>M14</td><td>WT</td><td>WT</td></tr><tr><td>MALME-3M</td><td>WT</td><td>WT</td></tr><tr><td>MDA-MB-435</td><td>WT</td><td>WT</td></tr><tr><td>SK-MEL-2</td><td>WT</td><td>WT</td></tr><tr><td>SK-MEL-28</td><td>WT</td><td>WT</td></tr><tr><td>SK-MEL-5</td><td>WT</td><td>WT</td></tr><tr><td>ACC-257</td><td>WT</td><td>WT</td></tr><tr><td>UACC-62</td><td>WT</td><td>WT</td></tr></table>
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<table><tr><td>BRAF mutant</td></tr><tr><td>WT</td></tr><tr><td>V600E</td></tr><tr><td>V600E</td></tr><tr><td>WT</td></tr><tr><td>WT</td></tr><tr><td>WT</td></tr><tr><td>V600E</td></tr><tr><td>V600E</td></tr><tr><td>V600E</td></tr><tr><td>V600E</td></tr><tr><td>V600E</td></tr><tr><td>V600E</td></tr><tr><td>V600E</td></tr><tr><td>V600E</td></tr><tr><td>V600E</td></tr></table>
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29da39f626a06e89d50b7395a1fb9dec5aae8157f4b3de97b96f23fac4d0d299.png
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complex
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<table><tr><td></td><td>Tolvaptan group</td><td>Conventional group</td><td><i>p</i> value</td></tr><tr><td>Number</td><td>26</td><td>180</td><td></td></tr><tr><td>Age (years)</td><td>75 ± 11</td><td>74 ± 12</td><td>0.88</td></tr><tr><td>Sex (male,%)</td><td>15 (58)</td><td>96 (53)</td><td>0.68</td></tr><tr><td>BMI (kg/m<sup>2</sup>)</td><td>23.8 ± 4.4</td><td>23.6 ± 4.4</td><td>0.77</td></tr><tr><td>Previous HF hospitalization</td><td>2.1 ± 1.7</td><td>0.5 ± 0.9</td><td><0.001</td></tr><tr><td colspan="4">Etiology of heart failure</td></tr><tr><td>Ischemic heart disease</td><td>8 (31)</td><td>68 (38)</td><td rowspan="4">0.87</td></tr><tr><td>Dilated cardiomyopathy</td><td>5 (19)</td><td>30 (17)</td></tr><tr><td>Valvular heart disease</td><td>5 (19)</td><td>26 (14)</td></tr><tr><td>Others</td><td>8 (31)</td><td>56 (31)</td></tr><tr><td colspan="4">Comorbid disease</td></tr><tr><td>Hypertension</td><td>20 (77)</td><td>136 (76)</td><td>0.88</td></tr><tr><td>Diabetes mellitus</td><td>14 (54)</td><td>81 (45)</td><td>0.40</td></tr><tr><td>Dyslipidemia</td><td>10 (38)</td><td>73 (41)</td><td>0.84</td></tr><tr><td>Atrial fibrillation</td><td>19 (73)</td><td>69 (38)</td><td><0.001</td></tr><tr><td colspan="4">Vital sign on admission</td></tr><tr><td>Heart rate (bpm)</td><td>79 ± 18</td><td>96 ± 27</td><td><0.001</td></tr><tr><td>SBP (mmHg)</td><td>123 ± 27</td><td>150 ± 38</td><td><0.001</td></tr><tr><td>DBP (mmHg)</td><td>71 ± 17</td><td>84 ± 22</td><td><0.01</td></tr><tr><td colspan="4">Blood chemistry on admission</td></tr><tr><td>Hemoglobin (g/dl)</td><td>10.3 ± 2.1</td><td>11.5 ± 2.3</td><td><0.05</td></tr><tr><td>BUN (mg/dl)</td><td>48 ± 27</td><td>28 ± 17</td><td><0.001</td></tr><tr><td>Scr (mg/dl)</td><td>2.0 ± 1.0</td><td>1.5 ± 1.4</td><td><0.001</td></tr><tr><td>eGFR (ml/min/1.73 m<sup>2</sup>)</td><td>30.7 ± 17.6</td><td>50.1 ± 27.3</td><td><0.001</td></tr><tr><td>eGFR <30 ml/min/1.73 m<sup>2</sup> (%)</td><td>15 (58)</td><td>47 (26)</td><td><0.005</td></tr><tr><td>Na (mEq/l)</td><td>137 ± 6</td><td>139 ± 4</td><td>0.22</td></tr><tr><td>K (mEq/l)</td><td>4.3 ± 1.0</td><td>4.2 ± 0.7</td><td>0.38</td></tr><tr><td>BNP (pg/ml)</td><td>746 (241–1527)</td><td>845 (465–1693)</td><td>0.23</td></tr><tr><td colspan="4">Medication on admission</td></tr><tr><td>β-blockers</td><td>18 (69)</td><td>59 (33)</td><td><0.001</td></tr><tr><td>RAS inhibitors</td><td>20 (77)</td><td>98 (54)</td><td><0.05</td></tr><tr><td>Loop diuretics</td><td>26 (100)</td><td>92 (51)</td><td><0.001</td></tr><tr><td>Thiazide diuretics</td><td>8 (26)</td><td>16 (9)</td><td><0.005</td></tr><tr><td>Aldosterone antagonists</td><td>14 (54)</td><td>32 (18)</td><td><0.05</td></tr><tr><td>Device therapy</td><td>7 (27)</td><td>28 (16)</td><td>0.15</td></tr></table>
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<table><tr><td></td><td>Tolvaptan group</td><td>Conventional group</td><td>p value</td></tr><tr><td>Number</td><td>26</td><td>180</td><td></td></tr><tr><td>Age (year</td><td>75</td><td>7</td><td>0.88</td></tr></table>
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<table><tr><td></td><td>Tolvaptan group</td><td>Conventional group</td><td>p value</td></tr><tr><td>s)</td><td> Β± 11</td><td>4 Β± 12</td><td></td></tr><tr><td>Sex (male,%)</td><td>15 (58)</td><td>96 (53)</td><td>0.68</td></tr><tr><td>BMI (kg/m2)</td><td>23.8 Β± 4.4</td><td>23.6 Β± 4.4</td><td>0.77</td></tr><tr><td>Previous HF hospitalization</td><td>2.1 Β± 1.7</td><td>0.5 Β± 0.9</td><td><0.001</td></tr><tr><td colspan="4">Etiology of heart failure</td></tr><tr><td>Ischemic heart disease</td><td>8 (31)</td><td>68 (38)</td><td rowspan="4">0.87</td></tr><tr><td>Dilated cardiomyopathy</td><td>5 (19)</td><td>30 (17)</td></tr><tr><td>Valvular heart disease</td><td>5 (19)</td><td>26 (14)</td></tr><tr><td>Others</td><td>8 (31)</td><td>56 (31)</td></tr><tr><td colspan="4">Comorbid disease</td></tr><tr><td>Hypertension</td><td>20 (77)</td><td>136 (76)</td><td>0.88</td></tr><tr><td>Diabetes mellitus</td><td>14 (54)</td><td>81 (45)</td><td>0.40</td></tr><tr><td>Dyslipidemia</td><td>10 (38)</td><td>73 (41)</td><td>0.84</td></tr><tr><td>Atrial fibrillation</td><td>19 (73)</td><td>69 (38)</td><td><0.001</td></tr><tr><td colspan="4">Vital sign on admission</td></tr><tr><td>Heart rate (bpm)</td><td>79 Β± 18</td><td>96 Β± 27</td><td><0.001</td></tr><tr><td>SBP (mmHg)</td><td>123 Β± 27</td><td>150 Β± 38</td><td><0.001</td></tr><tr><td>DBP (mmHg)</td><td>71 Β± 17</td><td>84 Β± 22</td><td><0.01</td></tr><tr><td colspan="4">Blood chemistry on admission</td></tr><tr><td>Hemoglobin (g/dl)</td><td>10.3 Β± 2.1</td><td>11.5 Β± 2.3</td><td><0.05</td></tr><tr><td>BUN (mg/dl)</td><td>48 Β± 27</td><td>28 Β± 17</td><td><0.001</td></tr><tr><td>Scr (mg/dl)</td><td>2.0 Β± 1.0</td><td>1.5 Β± 1.4</td><td><0.001</td></tr><tr><td>eGFR (ml/min/1.73 m2)</td><td>30.7 Β± 17.6</td><td>50.1 Β± 27.3</td><td><0.001</td></tr><tr><td>eGFR <30 ml/min/1.73 m2 (%)</td><td>15 (58)</td><td>47 (26)</td><td><0.005</td></tr><tr><td>Na (mEq/l)</td><td>137 Β± 6</td><td>139 Β± 4</td><td>0.22</td></tr><tr><td>K (mEq/l)</td><td>4.3 Β± 1.0</td><td>4.2 Β± 0.7</td><td>0.38</td></tr><tr><td>BNP (pg/ml)</td><td>746 (241β1527)</td><td>845 (465β1693)</td><td>0.23</td></tr><tr><td colspan="4">Medication on admission</td></tr><tr><td>Ξ²-blockers</td><td>18 (69)</td><td>59 (33)</td><td><0.001</td></tr><tr><td>RAS inhibitors</td><td>20 (77)</td><td>98 (54)</td><td><0.05</td></tr><tr><td>Loop diuretics</td><td>26 (100)</td><td>92 (51)</td><td><0.001</td></tr><tr><td>Thiazide diuretics</td><td>8 (26)</td><td>16 (9)</td><td><0.005</td></tr><tr><td>Aldosterone antagonists</td><td>14 (54)</td><td>32 (18)</td><td><0.05</td></tr><tr><td>Device therapy</td><td>7 (27)</td><td>28 (16)</td><td>0.15</td></tr></table>
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1b0dae4c6b613c953b63519367e222eda6b6746d130fc842a0d5873cfd6f60e7.png
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complex
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<table><tr><td colspan="2">Diagnosis</td><td>Diagnostic Clues</td></tr><tr><td colspan="2">Psoriasis</td><td>Usually involves extensor, palmar, plantar, nails and extensor areas. Thick plaques sharply limited with silvery white scales. Positive family history. Arthritis present in 10% of patients. Uncommon in children.</td></tr><tr><td colspan="2">Atopic Dermatitis</td><td>First appearance after 3 months of age, pruritus and restlessness are common. Frequently involves scalp, cheeks and extensor areas. Flexures involvement is more frequent in older ages. Family history of atopy such as eczema, allergic rhinitis and asthma. Self resolved by age 12.</td></tr><tr><td colspan="2">Tinea Capitis</td><td>Commonly seen in children, frequently accompanied by hair loss patches with “black dots” (broken hair). Highly contagious. KOH examination of the hair shaft and fungal culture confirm the diagnosis. Household members of patient should be examined.</td></tr><tr><td colspan="2">Rosacea</td><td>Usually targets the face. Papulopustules and telangiectasias on the malar, nose and perioral regions with slight desquamation. Recurrent edema and flushing.</td></tr><tr><td colspan="2">Systemic Lupus Erythematous (SLE)</td><td>In acute stage, butterfly rash on face that spares the nose bridge or nasolabial folds. Photosensitivity is common. Skin lesions are generally associated with other clinical signs of SLE. Histology and serologic tests such as antinuclear autoantibodies confirm the diagnosis.</td></tr><tr><td rowspan="5">Others</td><td>Pemphigus Foliaceous</td><td>Erythema, scaling and crusting that first present on the scalp and face can expand to chest and back. Histology, direct immunofluorescence with anti-desmoglein antibodies confirm diagnosis.</td></tr><tr><td>Pityriasis Rosea</td><td>Abrupt onset, appearance of herald patch and resolution within weeks.</td></tr><tr><td>Secondary syphilis</td><td>Peripheral lymph-adenopathy, mucosal lesions and palmoplantar macula-papules. Serology tests such as VDRL/ RPR, FTA-ABS* confirm diagnosis.</td></tr><tr><td>Diaper Dermatitis</td><td>Occurs on convex skin surfaces in contact with diaper, such as lower abdomen, genitalia, buttocks and upper thighs. Spares skin folds. Pustules are common.</td></tr><tr><td>Langerhans cell histiocytosis</td><td>Multisystem disease. Brown to purplish papules prone to coalesce on the scalp, retro-auricular areas, axillae and inguinal folds. Possible lytic bone lesions, liver, spleen and lung involvement. Histology confirms diagnosis.</td></tr></table>
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<table><tr><td colspan="2">Diagnosis</td><td>Diagnostic Clues</td></tr><tr><td colspan="2">Psoriasis</td><td>Usually involves extensor, palmar, plantar, nails and extensor areas. Thick plaques sharply limited with silvery white scales. Positive family history. Arthritis present in 10% of patients. Uncommon in children.</td></tr><tr><td colspan="2">Atopic Dermatitis</td><td>First appearance after 3 months of age, pruritus and restlessness are common. Frequently involves scalp, cheeks and extensor areas. Flexures involvement is more frequent in older ages. Family history of atopy such as eczema, allergic rhinitis and asthma. Self resolved by age 12.</td></tr><tr><td colspan="2">Tinea Capitis</td><td>Commonly seen in children, frequently accompanied by hair loss patches with βblack dotsβ (broken hair). Highly contagious. KOH examination of the hair shaft and fungal culture confirm the diagnosis. Household members of patient should be examined.</td></tr><tr><td colspan="2">Rosa</td><td>Usually targets the face. Papulopustules and telangiectasias on the malar, nose and perioral regions w</td></tr></table>
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<table><tr><td colspan="2">cea</td><td>ith slight desquamation. Recurrent edema and flushing.</td></tr><tr><td colspan="2">Systemic Lupus Erythematous (SLE)</td><td>In acute stage, butterfly rash on face that spares the nose bridge or nasolabial folds. Photosensitivity is common. Skin lesions are generally associated with other clinical signs of SLE. Histology and serologic tests such as antinuclear autoantibodies confirm the diagnosis.</td></tr><tr><td rowspan="5">Others</td><td>Pemphigus Foliaceous</td><td>Erythema, scaling and crusting that first present on the scalp and face can expand to chest and back. Histology, direct immunofluorescence with anti-desmoglein antibodies confirm diagnosis.</td></tr><tr><td>Pityriasis Rosea</td><td>Abrupt onset, appearance of herald patch and resolution within weeks.</td></tr><tr><td>Secondary syphilis</td><td>Peripheral lymph-adenopathy, mucosal lesions and palmoplantar macula-papules. Serology tests such as VDRL/ RPR, FTA-ABS* confirm diagnosis.</td></tr><tr><td>Diaper Dermatitis</td><td>Occurs on convex skin surfaces in contact with diaper, such as lower abdomen, genitalia, buttocks and upper thighs. Spares skin folds. Pustules are common.</td></tr><tr><td>Langerhans cell histiocytosis</td><td>Multisystem disease. Brown to purplish papules prone to coalesce on the scalp, retro-auricular areas, axillae and inguinal folds. Possible lytic bone lesions, liver, spleen and lung involvement. Histology confirms diagnosis.</td></tr></table>
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03bdd2205dab4e85fd53bf0870b42acad2f2fc56b719ff04bd7a26be9cc7ada3.png
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simple
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<table><tr><td>Assembler</td><td>Type<sup>†</sup></td><td>Splits reads*</td><td>Author</td><td>Cost</td><td>Source available</td><td>URL</td></tr><tr><td>CAP3</td><td>OLC†</td><td>No</td><td>X Huang and A Madan [38]</td><td>Free for use at non-profit organizations</td><td>No</td><td>http://seq.cs.iastate.edu/</td></tr><tr><td>CLC Assembly Cell 3.0</td><td>de Bruijn graph</td><td>Yes</td><td>CLC</td><td>Request quote or trial license</td><td>No</td><td>http://www.clcbio.com/</td></tr><tr><td>MIRA 3.0</td><td>OLC</td><td>No</td><td>Bastien Chevreux [40]</td><td>Free</td><td>Yes, GPL</td><td>http://sourceforge.net/projects/mira-assembler/</td></tr><tr><td>Newbler 2.3 and Newbler 2.5</td><td>OLC</td><td>Yes</td><td>Roche 454 [37]</td><td>Free for academic use</td><td>No</td><td>http://454.com/products-solutions/analysis-tools/gs-de-novo-assembler.asp</td></tr><tr><td>SeqMan NGen 2.1</td><td>OLC</td><td>No</td><td>DNAStar [41]</td><td>Request quote or trial license</td><td>No</td><td>http://www.dnastar.com/t-products-seqman-ngen.aspx</td></tr></table>
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<table><tr><td>Assembler</td><td>Typeβ </td><td>Splits reads*</td><td>Author</td><td>Cost</td><td>Source available</td><td>URL</td></tr><tr><td>CAP3</td><td>OLCβ </td><td>No</td><td>X Huang and A Madan [38]</td><td>Free for use at non-profit organizations</td><td>No</td><td>http://seq.cs.iastate.edu/</td></tr><tr><td>CLC Assembly Cell 3.0</td><td>de Bruijn graph</td><td>Yes</td><td>CLC</td><td>Request quote or trial license</td><td>No</td><td>http://www.clcbio.com/</td></tr></table>
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<table><tr><td>MIRA 3.0</td><td>OLC</td><td>No</td><td>Bastien Chevreux [40]</td><td>Free</td><td>Yes, GPL</td><td>http://sourceforge.net/projects/mira-assembler/</td></tr><tr><td>Newbler 2.3 and Newbler 2.5</td><td>OLC</td><td>Yes</td><td>Roche 454 [37]</td><td>Free for academic use</td><td>No</td><td>http://454.com/products-solutions/analysis-tools/gs-de-novo-assembler.asp</td></tr><tr><td>SeqMan NGen 2.1</td><td>OLC</td><td>No</td><td>DNAStar [41]</td><td>Request quote or trial license</td><td>No</td><td>http://www.dnastar.com/t-products-seqman-ngen.aspx</td></tr></table>
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cb54a0e31cbd93f8b1c945e924a4c3c8dff1d91668e2262b394bd411c643e9ce.png
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simple
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<table><tr><td>Trait</td><td><i>b</i><sub>( <i>P </i>, <i>DGV </i>)</sub></td><td><i>r</i><sub>( <i>DGV </i>, <i>P </i>)</sub></td><td>Accuracy</td></tr><tr><td>14:0</td><td>0.93</td><td>0.43</td><td>0.57</td></tr><tr><td>16:0</td><td>0.95</td><td>0.38</td><td>0.53</td></tr><tr><td>18:0</td><td>0.66</td><td>0.20</td><td>0.27</td></tr><tr><td><i>cis-</i>9 18:1</td><td>0.77</td><td>0.26</td><td>0.35</td></tr><tr><td><i>cis-</i>12 18:1</td><td>0.89</td><td>0.18</td><td>0.35</td></tr><tr><td><i>trans</i>-12 18:1</td><td>0.03</td><td>0.01</td><td>0.03</td></tr><tr><td>18:3n3</td><td>0.13</td><td>0.01</td><td>0.03</td></tr><tr><td>18:3n6</td><td>0.22</td><td>0.06</td><td>0.21</td></tr><tr><td>20:3n3</td><td>-0.47</td><td>-0.02</td><td>-0.06</td></tr><tr><td>20:3n6</td><td>-0.04</td><td>-0.01</td><td>-0.02</td></tr><tr><td>20:4</td><td>0.03</td><td>0.00</td><td>0.01</td></tr><tr><td>CLAc9t11</td><td>1.53</td><td>0.10</td><td>0.29</td></tr><tr><td>CLAt10c12</td><td>0.04</td><td>0.00</td><td>0.01</td></tr><tr><td>LCFA</td><td>0.95</td><td>0.42</td><td>0.57</td></tr><tr><td>MCFA</td><td>0.95</td><td>0.43</td><td>0.57</td></tr><tr><td>MUFA</td><td>0.87</td><td>0.26</td><td>0.38</td></tr><tr><td>PUFA</td><td>0.37</td><td>0.04</td><td>0.08</td></tr><tr><td>SFA</td><td>0.84</td><td>0.34</td><td>0.45</td></tr><tr><td>PUFA/SFA</td><td>0.45</td><td>0.06</td><td>0.12</td></tr><tr><td>(14:0+16:0)/All</td><td>0.94</td><td>0.40</td><td>0.55</td></tr><tr><td>Al</td><td>0.92</td><td>0.43</td><td>0.56</td></tr><tr><td>n3</td><td>-0.01</td><td>-0.01</td><td>-0.01</td></tr><tr><td>n6</td><td>0.18</td><td>0.02</td><td>0.07</td></tr><tr><td>n3/n6</td><td>0.00</td><td>0.00</td><td>0.00</td></tr></table>
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<table><tr><td>Trait</td><td>b( P , DGV )</td></tr><tr><td>14:0</td><td>0.93</td></tr><tr><td>16:0</td><td>0.95</td></tr><tr><td>18:0</td><td>0.66</td></tr><tr><td>cis-9 18:1</td><td>0.77</td></tr><tr><td>cis-12 18:1</td><td>0.89</td></tr><tr><td>trans-12 18:1</td><td>0.03</td></tr><tr><td>18:3n3</td><td>0.13</td></tr><tr><td>18:3n6</td><td>0.22</td></tr><tr><td>20:3n3</td><td>-0.47</td></tr><tr><td>20:3n6</td><td>-0.04</td></tr><tr><td>20:4</td><td>0.03</td></tr><tr><td>CLAc9t11</td><td>1.53</td></tr><tr><td>CLAt10c12</td><td>0.04</td></tr><tr><td>LCFA</td><td>0.95</td></tr><tr><td>MCFA</td><td>0.95</td></tr><tr><td>MUFA</td><td>0.87</td></tr><tr><td>PUFA</td><td>0.37</td></tr><tr><td>SFA</td><td>0.84</td></tr><tr><td>PUFA/SFA</td><td>0.45</td></tr><tr><td>(14:0+16:0)/All</td><td>0.94</td></tr><tr><td>Al</td><td>0.92</td></tr><tr><td>n3</td><td>-0.01</td></tr><tr><td>n6</td><td>0.18</td></tr><tr><td>n3/n6</td><td>0.00</td></tr></table>
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<table><tr><td>r( DGV , P )</td><td>Accuracy</td></tr><tr><td>0.43</td><td>0.57</td></tr><tr><td>0.38</td><td>0.53</td></tr><tr><td>0.20</td><td>0.27</td></tr><tr><td>0.26</td><td>0.35</td></tr><tr><td>0.18</td><td>0.35</td></tr><tr><td>0.01</td><td>0.03</td></tr><tr><td>0.01</td><td>0.03</td></tr><tr><td>0.06</td><td>0.21</td></tr><tr><td>-0.02</td><td>-0.06</td></tr><tr><td>-0.01</td><td>-0.02</td></tr><tr><td>0.00</td><td>0.01</td></tr><tr><td>0.10</td><td>0.29</td></tr><tr><td>0.00</td><td>0.01</td></tr><tr><td>0.42</td><td>0.57</td></tr><tr><td>0.43</td><td>0.57</td></tr><tr><td>0.26</td><td>0.38</td></tr><tr><td>0.04</td><td>0.08</td></tr><tr><td>0.34</td><td>0.45</td></tr><tr><td>0.06</td><td>0.12</td></tr><tr><td>0.40</td><td>0.55</td></tr><tr><td>0.43</td><td>0.56</td></tr><tr><td>-0.01</td><td>-0.01</td></tr><tr><td>0.02</td><td>0.07</td></tr><tr><td>0.00</td><td>0.00</td></tr></table>
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a2598b61e1bf04342679897a9c88ef0a6bc37fadb28af439bb7fb7e70013a82d.png
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complex
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<table><tr><td></td><td></td><td>MZ</td><td>DZ</td><td>Total no pairs</td></tr><tr><td rowspan="3">IBS</td><td>Concordant pairs</td><td>14</td><td>10</td><td>24</td></tr><tr><td>Discordant pairs</td><td>95</td><td>193</td><td>288</td></tr><tr><td>Probandwise concordance rate</td><td>0.23</td><td>0.09*</td><td></td></tr><tr><td rowspan="3">Depression</td><td>Concordant pairs</td><td>67</td><td>82</td><td>149</td></tr><tr><td>Discordant pairs</td><td>232</td><td>455</td><td>687</td></tr><tr><td>Probandwise concordance rate</td><td>0.22</td><td>0.15*</td><td></td></tr><tr><td rowspan="3">Anxiety</td><td>Concordant pairs</td><td>56</td><td>55</td><td>111</td></tr><tr><td>Discordant pairs</td><td>186</td><td>422</td><td>608</td></tr><tr><td>Probandwise concordance rate</td><td>0.23</td><td>0.12*</td><td></td></tr></table>
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<table><tr><td></td><td></td><td>MZ</td><td>DZ</td><td>Total no pairs</td></tr><tr><td rowspan="3">IBS</td><td>Concordant pairs</td><td>14</td><td>10</td><td>24</td></tr><tr><td>Discordant pairs</td><td>95</td><td>193</td><td>288</td></tr><tr><td>Probandwise concordance rate</td><td>0.23</td><td>0.09*</td><td></td></tr><tr><td rowspan="2">Depression</td><td>Concordant pairs</td><td>67</td><td>82</td><td>149</td></tr><tr><td>Discordant pairs</td><td>232</td><td>455</td><td>687</td></tr></table>
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<table><tr><td>Depression</td><td>Probandwise concordance rate</td><td>0.22</td><td>0.15*</td><td></td></tr><tr><td rowspan="3">Anxiety</td><td>Concordant pairs</td><td>56</td><td>55</td><td>111</td></tr><tr><td>Discordant pairs</td><td>186</td><td>422</td><td>608</td></tr><tr><td>Probandwise concordance rate</td><td>0.23</td><td>0.12*</td><td></td></tr></table>
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139d77f11bd39e31ff2279d7cc7432544d1a542d0278d7d21f3529ee1af22d09.png
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complex
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<table><tr><td> </td><td>Ashford <i>et al</i>.[46](MMSE)</td><td>Gibbons <i>et al</i>.[48]UK (MMSE)</td><td>Gibbons <i>et al.</i>[48]US (MMSE)</td><td>Mungas and Reed[1](BIMCT/MMSE)</td></tr><tr><td rowspan="2">Truncated above upper limit</td><td>Recall: tree</td><td>No ifs ands or buts</td><td rowspan="2"> </td><td rowspan="2"> </td></tr><tr><td>Recall: flag</td><td>Recall nouns</td></tr><tr><td rowspan="5">1st quartile (most difficult)</td><td>Serial sevens: subtraction 5</td><td>Orientation to date</td><td>Orientation to date</td><td>Recall ‘42’ (BIMCT)</td></tr><tr><td>Serial sevens: subtraction 3</td><td>Verbal directions</td><td>No ifs ands or buts</td><td>Recall ‘Market Street’ (BIMCT)</td></tr><tr><td>Orientation to date</td><td>Intersecting pentagons</td><td>Intersecting pentagons</td><td>Recall ‘John’ (BIMCT)</td></tr><tr><td rowspan="2">Recall: Ball</td><td rowspan="2">Serial sevens</td><td rowspan="2">Serial sevens</td><td>Recall ‘Chicago’ (BIMCT)</td></tr><tr><td>Recall ‘Brown’ (BIMCT)</td></tr><tr><td rowspan="10">2nd quartile</td><td>Serial sevens: subtraction 4</td><td>Orientation to year</td><td>Recall nouns</td><td>Orientation to year (BIMCT/MMSE)</td></tr><tr><td>Serial sevens: subtraction 2</td><td>Orientation to county/streets</td><td>Orientation to day</td><td>Orientation to month (BIMCT/MMSE)</td></tr><tr><td>Orientation to day</td><td>Orientation to day</td><td>Orientation to year</td><td rowspan="8">Age (BIMCT)</td></tr><tr><td>Orientation to county</td><td>Orientation to month</td><td>Orientation to season</td></tr><tr><td>Orientation to month</td><td> </td><td>Orientation to month</td></tr><tr><td>Serial sevens: subtraction 1</td><td rowspan="5"> </td><td rowspan="5">Orientation to county/streets</td></tr><tr><td>Orientation to year</td></tr><tr><td>Orientation to season</td></tr><tr><td>Orientation to place</td></tr><tr><td>Orientation to floor</td></tr><tr><td rowspan="7">3rd quartile</td><td>Orientation to city</td><td>Orientation to state/county</td><td>Orientation to address</td><td>Orientation to state (MMSE)</td></tr><tr><td>Intersecting pentagons</td><td>Write sentence</td><td>Verbal directions</td><td>Type of work (BIMCT)</td></tr><tr><td>Orientation to state</td><td>Orientation to</td><td>Write sentence</td><td>Count forward (BIMCT)</td></tr><tr><td>Write sentence</td><td>Season</td><td>Orientation to place</td><td rowspan="4">Name watch (MMSE)</td></tr><tr><td>No ifs ands or buts</td><td rowspan="3">Orientation to Address</td><td rowspan="3">Orientation to city</td></tr><tr><td>Name watch</td></tr><tr><td>Verbal directions: paper-on floor</td></tr><tr><td rowspan="7">4th quartile (least difficult)</td><td>Close eyes</td><td>Repeat nouns</td><td>Orientation to state</td><td>Place of birth (BIMCT)</td></tr><tr><td>Repeat: flag</td><td>Orientation to city/town/village</td><td>Close eyes</td><td>Name pencil (MMSE)</td></tr><tr><td>Name pencil</td><td rowspan="5">Orientation to room</td><td rowspan="5">Name objects</td><td rowspan="5">Name (BIMCT)</td></tr><tr><td>Repeat: ball</td></tr><tr><td>Repeat: tree</td></tr><tr><td>Verbal directions: paper-take in right hand</td></tr><tr><td>Verbal directions: paper-fold in half</td></tr><tr><td rowspan="2">Truncated below 0</td><td rowspan="2"> </td><td>Close eyes</td><td rowspan="2">Repeat nouns</td><td rowspan="2"> </td></tr><tr><td>Name objects</td></tr></table>
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<table><tr><td></td><td>Ashford et al.[46](MMSE)</td><td>Gibbons et al.[48]UK (MMSE)</td><td>Gibbons et al.[48]US (MMSE)</td><td>Mungas and Reed[1](BIMCT/MMSE)</td></tr></table>
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<table><tr><td rowspan="2">Truncated above upper limit</td><td>Recall: tree</td><td>No ifs ands or buts</td><td rowspan="2"></td><td rowspan="2"></td></tr><tr><td>Recall: flag</td><td>Recall nouns</td></tr><tr><td rowspan="5">1st quartile (most difficult)</td><td>Serial sevens: subtraction 5</td><td>Orientation to date</td><td>Orientation to date</td><td>Recall β42β (BIMCT)</td></tr><tr><td>Serial sevens: subtraction 3</td><td>Verbal directions</td><td>No ifs ands or buts</td><td>Recall βMarket Streetβ (BIMCT)</td></tr><tr><td>Orientation to date</td><td>Intersecting pentagons</td><td>Intersecting pentagons</td><td>Recall βJohnβ (BIMCT)</td></tr><tr><td rowspan="2">Recall: Ball</td><td rowspan="2">Serial sevens</td><td rowspan="2">Serial sevens</td><td>Recall βChicagoβ (BIMCT)</td></tr><tr><td>Recall βBrownβ (BIMCT)</td></tr><tr><td rowspan="10">2nd quartile</td><td>Serial sevens: subtraction 4</td><td>Orientation to year</td><td>Recall nouns</td><td>Orientation to year (BIMCT/MMSE)</td></tr><tr><td>Serial sevens: subtraction 2</td><td>Orientation to county/streets</td><td>Orientation to day</td><td>Orientation to month (BIMCT/MMSE)</td></tr><tr><td>Orientation to day</td><td>Orientation to day</td><td>Orientation to year</td><td rowspan="8">Age (BIMCT)</td></tr><tr><td>Orientation to county</td><td>Orientation to month</td><td>Orientation to season</td></tr><tr><td>Orientation to month</td><td></td><td>Orientation to month</td></tr><tr><td>Serial sevens: subtraction 1</td><td rowspan="5"></td><td rowspan="5">Orientation to county/streets</td></tr><tr><td>Orientation to year</td></tr><tr><td>Orientation to season</td></tr><tr><td>Orientation to place</td></tr><tr><td>Orientation to floor</td></tr><tr><td rowspan="7">3rd quartile</td><td>Orientation to city</td><td>Orientation to state/county</td><td>Orientation to address</td><td>Orientation to state (MMSE)</td></tr><tr><td>Intersecting pentagons</td><td>Write sentence</td><td>Verbal directions</td><td>Type of work (BIMCT)</td></tr><tr><td>Orientation to state</td><td>Orientation to</td><td>Write sentence</td><td>Count forward (BIMCT)</td></tr><tr><td>Write sentence</td><td>Season</td><td>Orientation to place</td><td rowspan="4">Name watch (MMSE)</td></tr><tr><td>No ifs ands or buts</td><td rowspan="3">Orientation to Address</td><td rowspan="3">Orientation to city</td></tr><tr><td>Name watch</td></tr><tr><td>Verbal directions: paper-on floor</td></tr><tr><td rowspan="7">4th quartile (least difficult)</td><td>Close eyes</td><td>Repeat nouns</td><td>Orientation to state</td><td>Place of birth (BIMCT)</td></tr><tr><td>Repeat: flag</td><td>Orientation to city/town/village</td><td>Close eyes</td><td>Name pencil (MMSE)</td></tr><tr><td>Name pencil</td><td rowspan="5">Orientation to room</td><td rowspan="5">Name objects</td><td rowspan="5">Name (BIMCT)</td></tr><tr><td>Repeat: ball</td></tr><tr><td>Repeat: tree</td></tr><tr><td>Verbal directions: paper-take in right hand</td></tr><tr><td>Verbal directions: paper-fold in half</td></tr><tr><td rowspan="2">Truncated below 0</td><td rowspan="2"></td><td>Close eyes</td><td rowspan="2">Repeat nouns</td><td rowspan="2"></td></tr><tr><td>Name objects</td></tr></table>
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ce858e91e6789702870f3719a49dba88b7f9f3788a6c10da8b334633ff2f2f3e.png
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complex
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<table><tr><td>Chr</td><td>GWAS QTL</td><td>Bi-parental counterpart</td><td>Bins</td><td>Marker associated with GLS resistance QTL</td><td>Source of variation<sup>a</sup></td><td>Minor allele frequency</td><td>Physical coordinate</td><td>SNP effects</td><td>Heritability of a SNP<sup>b</sup></td><td>Maximum heritability of a chromosome</td></tr><tr><td>1</td><td>DTS_1.1</td><td></td><td>1.01-1.02</td><td>GLS-SNP-5365</td><td>[T/G]</td><td>0.30</td><td>12,255,366</td><td>0.07989852</td><td>0.001049039</td><td>0.003070336</td></tr><tr><td>1</td><td>GLS1.1</td><td></td><td>1.02</td><td>GLS-SNP-1590</td><td>[<underline>T</underline>/C]</td><td>0.43</td><td>15,354,490</td><td>−0.01960145</td><td>0.003070336</td><td>0.003070336</td></tr><tr><td>1</td><td>DTS_1.2</td><td></td><td>1.02</td><td>GLS-SNP-0156</td><td>[T/C]</td><td>0.42</td><td>22,510,157</td><td>0.04407421</td><td>0.003070336</td><td>0.003070336</td></tr><tr><td>1</td><td>DTS_1.3</td><td></td><td>1.03</td><td>GLS-SNP-0538</td><td>[A/G]</td><td>0.23</td><td>35,460,539</td><td>0.04052954</td><td>0.003070336</td><td>0.003070336</td></tr><tr><td>1</td><td>DTS_1.4</td><td></td><td>1.03</td><td>PZE-101061225</td><td>[G/T]</td><td>0.12</td><td>45,115,245</td><td>−0.04252824</td><td>0.003070336</td><td>0.003070336</td></tr><tr><td>1</td><td>DTS_1.5</td><td></td><td>1.03</td><td>GLS-SNP-2651</td><td>[A/G]</td><td>0.32</td><td>48,092,652</td><td>0.41783421</td><td>0.003070336</td><td>0.003070336</td></tr><tr><td>1</td><td>DTS_1.6</td><td></td><td>1.05</td><td>GLS-SNP-2138</td><td>[T/C]</td><td>0.46</td><td>101,832,139</td><td>0.43211445</td><td>0.003070336</td><td>0.003070336</td></tr><tr><td>1</td><td>DTS_1.7</td><td></td><td>1.07</td><td>GLS-SNP-5094</td><td>[A/G]</td><td>0.49</td><td>203,245,095</td><td>−0.69856342</td><td>0.003070336</td><td>0.003070336</td></tr><tr><td>1</td><td>GLS 1.2</td><td><i>QTLGLSchr1</i></td><td>1.08</td><td>PZE-101188909</td><td>[<underline>A</underline>/G]</td><td>0.23</td><td>234,309,200</td><td>−0.01785890</td><td>0.001971469</td><td>0.003070336</td></tr><tr><td>6</td><td>GLS 6.1</td><td><i>QTLGLSchr6</i></td><td>6.04</td><td>PZE-106058730</td><td>[<underline>A</underline>/G]</td><td>0.34</td><td>107,475,955</td><td>−0.00632726</td><td>0.000293801</td><td>0.00093559</td></tr><tr><td>6</td><td>GLS 6.2</td><td></td><td>6.04</td><td>PZE-106066216</td><td>[T/<underline>C</underline>]</td><td>0.42</td><td>118,304,229</td><td>0.01101481</td><td>0.000935590</td><td>0.00093559</td></tr><tr><td>6</td><td>DTS_6.1</td><td></td><td>6.05</td><td>Mo17-10397</td><td>[T/C]</td><td>0.41</td><td>151,787,329</td><td>0.04365824</td><td>0.000243429</td><td>0.00093559</td></tr><tr><td>6</td><td>GLS 6.3</td><td></td><td>6.05</td><td>PZE-106100504</td><td>[T/<underline>C</underline>]</td><td>0.32</td><td>153,414,853</td><td>0.00639998</td><td>0.000282006</td><td>0.00093559</td></tr><tr><td>6</td><td>DTS_6.2</td><td></td><td>6.06</td><td>GLS-SNP-4138</td><td>[A/C]</td><td>0.45</td><td>155,634,139</td><td>0.06046048</td><td>0.000701479</td><td>0.00093559</td></tr><tr><td>6</td><td>GLS 6.4</td><td></td><td>6.06</td><td>MAGI_11553-2</td><td>[T/<underline>G</underline>]</td><td>0.37</td><td>156,981,627</td><td>0.00610662</td><td>0.000281211</td><td>0.00093559</td></tr><tr><td>7</td><td>DTS_7.1</td><td></td><td>7.00</td><td>PZE-107000932</td><td>[T/C]</td><td>0.50</td><td>1,121,016</td><td>−0.00193525</td><td>0.000617793</td><td>0.000660398</td></tr><tr><td>7</td><td>GLS 7.1</td><td></td><td>7.00</td><td>PZE-107004786</td><td>[T/<underline>C</underline>]</td><td>0.40</td><td>3,074,900</td><td>0.00916059</td><td>0.000660398</td><td>0.000660398</td></tr><tr><td>7</td><td>GLS 7.2</td><td><i>QTLGLSchr7</i></td><td>7.02</td><td>PZE-107020739</td><td>[<underline>G</underline>/A]</td><td>0.37</td><td>19,500,572</td><td>−0.00603602</td><td>0.000265353</td><td>0.000660398</td></tr><tr><td>7</td><td>DTS_7.2</td><td></td><td>7.02</td><td>PZE-107020739</td><td>[G/A]</td><td>0.37</td><td>19,500,572</td><td>0.00248297</td><td>0.000107170</td><td>0.000660398</td></tr><tr><td>7</td><td>DTS_7.3</td><td></td><td>7.02</td><td>PZE-107083430</td><td>[C/T]</td><td>0.23</td><td>125,687,825</td><td>0.00226143</td><td>0.000585325</td><td>0.000660398</td></tr><tr><td>7</td><td>DTS_7.4</td><td></td><td>7.03</td><td>PZE-107094672</td><td>[A/G]</td><td>0.4</td><td>144,404,803</td><td>−0.00229674</td><td>0.000599634</td><td>0.000660398</td></tr><tr><td>7</td><td>DTS_7.5</td><td></td><td>7.03</td><td>PZE-107099659</td><td>[T/C]</td><td>0.32</td><td>154,472,118</td><td>0.00345513</td><td>0.002230712</td><td>0.000660398</td></tr><tr><td>8</td><td>GLS 8.1</td><td></td><td>8.01</td><td>GLS-SNP-7688</td><td>[<underline>A</underline>/G]</td><td>0.26</td><td>6,253,558</td><td>−0.00608691</td><td>0.000242320</td><td>0.000585845</td></tr><tr><td>8</td><td rowspan="2">GLS 8.2</td><td rowspan="2"><i>QTLGLSchr8a</i></td><td>8.02</td><td>PZE-108020413</td><td>[T/<underline>C</underline>]</td><td>0.48</td><td>19,550,800</td><td>0.00468907</td><td>0.000177343</td><td>0.000585845</td></tr><tr><td>8</td><td>8.02</td><td>PZE-108022710</td><td>[T/<underline>G</underline>]</td><td>0.43</td><td>21,753,432</td><td>0.00584096</td><td>0.000269140</td><td>0.000585845</td></tr><tr><td>8</td><td rowspan="2">GLS 8.3</td><td rowspan="2"><i>QTLGLSchr8b</i></td><td>8.03</td><td>PZE-108047250</td><td>[<underline>T</underline>/C]</td><td>0.46</td><td>79,142,282</td><td>−0.00521772</td><td>0.000218764</td><td>0.000585845</td></tr><tr><td>8</td><td>8.03</td><td>PZE-108050268</td><td>[A/<underline>T</underline>]</td><td>0.10</td><td>87,682,262</td><td>0.00806870</td><td>0.000204892</td><td>0.000585845</td></tr><tr><td>8</td><td rowspan="3">GLS 8.4</td><td></td><td>8.05-8.06</td><td>GLS-SNP-1344</td><td>[<underline>A</underline>/G]</td><td>0.30</td><td>154,247,344</td><td>−0.00922446</td><td>0.000585845</td><td>0.000585845</td></tr><tr><td>8</td><td></td><td>8.05-8.06</td><td>PZE-108098666</td><td>[<underline>T</underline>/C]</td><td>0.23</td><td>155,016,277</td><td>−0.00709668</td><td>0.000296117</td><td>0.000585845</td></tr><tr><td>8</td><td></td><td>8.05-8.06</td><td>PZE-108098682</td><td>[<underline>A</underline>/G]</td><td>0.22</td><td>155,029,958</td><td>−0.00890310</td><td>0.000450864</td><td>0.000585845</td></tr><tr><td>8</td><td>GLS 8.5</td><td></td><td>8.05-8.06</td><td>PZE-108101351</td><td>[<underline>A</underline>/C]</td><td>0.13</td><td>157,169,975</td><td>−0.01000713</td><td>0.000374213</td><td>0.000585845</td></tr><tr><td>8</td><td>DTS_7.1</td><td></td><td>8.05-8.06</td><td>GLS-SNP-8600</td><td>[T/G]</td><td>0.25</td><td>145,906,568</td><td>−0.00301422</td><td>0.000131115</td><td>0.000585845</td></tr><tr><td>8</td><td>DTS_7.2</td><td></td><td>8.06</td><td>PZE-108109056</td><td>[A/C]</td><td>0.31</td><td>162,535,081</td><td>0.00382457</td><td>0.000270955</td><td>0.000585845</td></tr><tr><td>8</td><td>DTS_7.3</td><td></td><td>8.06</td><td>GLS-SNP-6472</td><td>[T/C]</td><td>0.38</td><td>162,586,473</td><td>0.00290281</td><td>0.000154292</td><td>0.000585845</td></tr><tr><td>8</td><td>DTS_7.4</td><td></td><td>8.06</td><td>GLS-SNP-8795</td><td>[T/G]</td><td>0.45</td><td>163,616,966</td><td>−0.00209331</td><td>0.000435068</td><td>0.000585845</td></tr></table>
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<table><tr><td>Chr</td><td>GWAS QTL</td><td>Bi-parental counterpart</td><td>Bins</td><td>Marker associated with GLS resistance QTL</td><td>Source of variationa</td><td>Minor allele frequency</td><td>Physical coordinate</td><td>SNP effects</td><td>Heritability of a SNPb</td><td>Maximum heritability of a chromosome</td></tr><tr><td>1</td><td>DTS_1.1</td><td></td><td>1.01-1.02</td><td>GLS-SNP-5365</td><td>[T/G]</td><td>0.30</td><td>12,255,366</td><td>0.07989852</td><td>0.001049039</td><td>0.003070336</td></tr><tr><td>1</td><td>GLS1.1</td><td></td><td>1.02</td><td>GLS-SNP-1590</td><td>[T/C]</td><td>0.43</td><td>15,354,490</td><td>β0.01960145</td><td>0.003070336</td><td>0.003070336</td></tr><tr><td>1</td><td>DTS_1.2</td><td></td><td>1.02</td><td>GLS-SNP-0156</td><td>[T/C]</td><td>0.42</td><td>22,510,157</td><td>0.04407421</td><td>0.003070336</td><td>0.003070336</td></tr><tr><td>1</td><td>DTS_1.3</td><td></td><td>1.03</td><td>GLS-SNP-0538</td><td>[A/G]</td><td>0.23</td><td>35,460,539</td><td>0.04052954</td><td>0.003070336</td><td>0.003070336</td></tr><tr><td>1</td><td>DTS_1.4</td><td></td><td>1.03</td><td>PZE-101061225</td><td>[G/T]</td><td>0.12</td><td>45,115,245</td><td>β0.04252824</td><td>0.003070336</td><td>0.003070336</td></tr><tr><td>1</td><td>DTS_1.5</td><td></td><td>1.03</td><td>GLS-SNP-2651</td><td>[A/G]</td><td>0.32</td><td>48,092,652</td><td>0.41783421</td><td>0.003070336</td><td>0.003070336</td></tr><tr><td>1</td><td>DTS_1.6</td><td></td><td>1.05</td><td>GLS-SNP-2138</td><td>[T/C]</td><td>0.46</td><td>101,832,139</td><td>0.43211445</td><td>0.003070336</td><td>0.003070336</td></tr><tr><td>1</td><td>DTS_1.7</td><td></td><td>1.07</td><td>GLS-SNP-5094</td><td>[A/G]</td><td>0.49</td><td>203,245,095</td><td>β0.69856342</td><td>0.003070336</td><td>0.003070336</td></tr><tr><td>1</td><td>GLS 1.2</td><td>QTLGLSchr1</td><td>1.08</td><td>PZE-101188909</td><td>[A/G]</td><td>0.23</td><td>234,309,200</td><td>β0.01785890</td><td>0.001971469</td><td>0.003070336</td></tr><tr><td>6</td><td>GLS 6.1</td><td>QTLGLSchr6</td><td>6.04</td><td>PZE-106058730</td><td>[A/G]</td><td>0.34</td><td>107,475,955</td><td>β0.00632726</td><td>0.000293801</td><td>0.00093559</td></tr><tr><td>6</td><td>GLS 6.2</td><td></td><td>6.04</td><td>PZE-106066216</td><td>[T/C]</td><td>0.42</td><td>118,304,229</td><td>0.01101481</td><td>0.000935590</td><td>0.00093559</td></tr><tr><td>6</td><td>DTS_6.1</td><td></td><td>6.05</td><td>Mo17-10397</td><td>[T/C]</td><td>0.41</td><td>151,787,329</td><td>0.04365824</td><td>0.000243429</td><td>0.00093559</td></tr><tr><td>6</td><td>GLS 6.3</td><td></td><td>6.05</td><td>PZE-106100504</td><td>[T/C]</td><td>0.32</td><td>153,414,853</td><td>0.00639998</td><td>0.000282006</td><td>0.00093559</td></tr><tr><td>6</td><td>DTS_6.2</td><td></td><td>6.06</td><td>GLS-SNP-4138</td><td>[A/C]</td><td>0.45</td><td>155,634,139</td><td>0.06046048</td><td>0.000701479</td><td>0.00093559</td></tr><tr><td>6</td><td>GLS 6.4</td><td></td><td>6.06</td><td>MAGI_11553-2</td><td>[T/G]</td><td>0.37</td><td>156,981,627</td><td>0.00610662</td><td>0.000281211</td><td>0.00093559</td></tr><tr><td>7</td><td>DTS_7.1</td><td></td><td>7.00</td><td>PZE-107000932</td><td>[T/C]</td><td>0.50</td><td>1,121,016</td><td>β0.00193525</td><td>0.000617793</td><td>0.000660398</td></tr><tr><td>7</td><td>GLS 7.1</td><td></td><td>7.00</td><td>PZE-107004786</td><td>[T/C]</td><td>0.40</td><td>3,074,900</td><td>0.00916059</td><td>0.000660398</td><td>0.000660398</td></tr><tr><td>7</td><td>GLS 7.2</td><td>QTLGLSchr7</td><td>7.02</td><td>PZE-107020739</td><td>[G/A]</td><td>0.37</td><td>19,500,572</td><td>β0.00603602</td><td>0.000265353</td><td>0.000660398</td></tr><tr><td>7</td><td>DTS_7.2</td><td></td><td>7.02</td><td>PZE-107020739</td><td>[G/A]</td><td>0.37</td><td>19,500,572</td><td>0.00248297</td><td>0.000107170</td><td>0.000660398</td></tr><tr><td>7</td><td>DTS_7.3</td><td></td><td>7.02</td><td>PZE-107083430</td><td>[C/T]</td><td>0.23</td><td>125,687,825</td><td>0.00226143</td><td>0.000585325</td><td>0.000660398</td></tr><tr><td>7</td><td>DTS_7.4</td><td></td><td>7.03</td><td>PZE-107094672</td><td>[A/G]</td><td>0.4</td><td>144,404,803</td><td>β0.00229674</td><td>0.000599634</td><td>0.000660398</td></tr><tr><td>7</td><td>DTS_7.5</td><td></td><td>7.03</td><td>PZE-107099659</td><td>[T/C]</td><td>0.32</td><td>154,472,118</td><td>0.00345513</td><td>0.002230712</td><td>0.000660398</td></tr><tr><td>8</td><td>GLS 8.1</td><td></td><td>8.01</td><td>GLS-SNP-7688</td><td>[A/G]</td><td>0.26</td><td>6,253,558</td><td>β0.00608691</td><td>0.000242320</td><td>0.000585845</td></tr></table>
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<table><tr><td>8</td><td rowspan="2">GLS 8.2</td><td rowspan="2">QTLGLSchr8a</td><td>8.02</td><td>PZE-108020413</td><td>[T/C]</td><td>0.48</td><td>19,550,800</td><td>0.00468907</td><td>0.000177343</td><td>0.000585845</td></tr><tr><td>8</td><td>8.02</td><td>PZE-108022710</td><td>[T/G]</td><td>0.43</td><td>21,753,432</td><td>0.00584096</td><td>0.000269140</td><td>0.000585845</td></tr><tr><td>8</td><td rowspan="2">GLS 8.3</td><td rowspan="2">QTLGLSchr8b</td><td>8.03</td><td>PZE-108047250</td><td>[T/C]</td><td>0.46</td><td>79,142,282</td><td>β0.00521772</td><td>0.000218764</td><td>0.000585845</td></tr><tr><td>8</td><td>8.03</td><td>PZE-108050268</td><td>[A/T]</td><td>0.10</td><td>87,682,262</td><td>0.00806870</td><td>0.000204892</td><td>0.000585845</td></tr><tr><td>8</td><td rowspan="3">GLS 8.4</td><td></td><td>8.05-8.06</td><td>GLS-SNP-1344</td><td>[A/G]</td><td>0.30</td><td>154,247,344</td><td>β0.00922446</td><td>0.000585845</td><td>0.000585845</td></tr><tr><td>8</td><td></td><td>8.05-8.06</td><td>PZE-108098666</td><td>[T/C]</td><td>0.23</td><td>155,016,277</td><td>β0.00709668</td><td>0.000296117</td><td>0.000585845</td></tr><tr><td>8</td><td></td><td>8.05-8.06</td><td>PZE-108098682</td><td>[A/G]</td><td>0.22</td><td>155,029,958</td><td>β0.00890310</td><td>0.000450864</td><td>0.000585845</td></tr><tr><td>8</td><td>GLS 8.5</td><td></td><td>8.05-8.06</td><td>PZE-108101351</td><td>[A/C]</td><td>0.13</td><td>157,169,975</td><td>β0.01000713</td><td>0.000374213</td><td>0.000585845</td></tr><tr><td>8</td><td>DTS_7.1</td><td></td><td>8.05-8.06</td><td>GLS-SNP-8600</td><td>[T/G]</td><td>0.25</td><td>145,906,568</td><td>β0.00301422</td><td>0.000131115</td><td>0.000585845</td></tr><tr><td>8</td><td>DTS_7.2</td><td></td><td>8.06</td><td>PZE-108109056</td><td>[A/C]</td><td>0.31</td><td>162,535,081</td><td>0.00382457</td><td>0.000270955</td><td>0.000585845</td></tr><tr><td>8</td><td>DTS_7.3</td><td></td><td>8.06</td><td>GLS-SNP-6472</td><td>[T/C]</td><td>0.38</td><td>162,586,473</td><td>0.00290281</td><td>0.000154292</td><td>0.000585845</td></tr><tr><td>8</td><td>DTS_7.4</td><td></td><td>8.06</td><td>GLS-SNP-8795</td><td>[T/G]</td><td>0.45</td><td>163,616,966</td><td>β0.00209331</td><td>0.000435068</td><td>0.000585845</td></tr></table>
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a9a5f88d618fb06aebc274745c2c590b121c06ca30ca2811e6cf508230c370e8.png
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simple
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<table><tr><td>Definition</td><td>Grade</td><td>Ki-67%</td><td>Mitotic index</td></tr><tr><td>NET - neuroendocrine tumour, low grade</td><td>G1</td><td>≤2</td><td><2</td></tr><tr><td>NET - neuroendocrine tumour, intermediate grade</td><td>G2</td><td>3 to 20</td><td>2 to 20</td></tr><tr><td>NET - neuroendocrine carcinoma, high grade</td><td>G3</td><td>>20</td><td>>20</td></tr></table>
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<table><tr><td>Definition</td><td>Grade</td><td>Ki-67%</td><td>Mitotic index</td></tr></table>
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<table><tr><td>NET - neuroendocrine tumour, low grade</td><td>G1</td><td>β€2</td><td><2</td></tr><tr><td>NET - neuroendocrine tumour, intermediate grade</td><td>G2</td><td>3 to 20</td><td>2 to 20</td></tr><tr><td>NET - neuroendocrine carcinoma, high grade</td><td>G3</td><td>>20</td><td>>20</td></tr></table>
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01c87d38848f661f633d7b0d55366e347455f002e2bd7ab97af6bddf995b11ab.png
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complex
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<table><tr><td></td><td colspan="2">Ectopic pregnancy<sup>a</sup></td><td colspan="2">Preterm delivery among live-born infants<sup>b</sup></td></tr><tr><td></td><td><i>n </i>(prevalence %)</td><td>Adjusted odds ratio (95% confidence interval)</td><td><i>n </i>(prevalence %)</td><td>Adjusted odds ratio (95% confidence interval)</td></tr><tr><td>Mother not diagnosed with SLE</td><td>5 (0.7%)</td><td>1.0 (-)</td><td>26 (4.7%)</td><td>1.0 (-)</td></tr><tr><td>Mother diagnosed with SLE</td><td>5 (1.4%)</td><td>3.6 (0.7–18.7)</td><td>19 (7.3%)</td><td>1.5 (0.7–3.2)</td></tr><tr><td>Pregnancy conceived prior to SLE diagnosis</td><td>3 (0.8%)</td><td>3.1(0.5–17.9)</td><td>12 (4.7%)</td><td>1.2(0.5–2.8)</td></tr><tr><td>Pregnancy conceived after SLE diagnosis</td><td>2 (0.6%)</td><td>7.5 (0.9–62.5)</td><td>7 (2.7%)</td><td>3.4 (1.2–10.0)</td></tr></table>
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<table><tr><td></td><td colspan="2">Ectopic pregnancya</td><td colspan="2">Preterm delivery among live-born infantsb</td></tr><tr><td></td><td>n (prevalence %)</td><td>Adjusted odds ratio (95% confidence interval)</td><td>n (prevalence %)</td><td>Adjusted odds ratio (95% confidence interval)</td></tr><tr><td>Mother not diagnosed with SLE</td><td>5 (0.7%)</td><td>1.0 (-)</td><td>26 (4.7%)</td><td>1.0 (-)</td></tr><tr><td>Mother diagnosed with SLE</td><td>5 (1.4%)</td><td>3.6 (0.7β18.7)</td><td>19 (7.3%)</td><td>1.5 (0.7β3.2)</td></tr></table>
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<table><tr><td></td><td colspan="2">Ectopic pregnancya</td><td colspan="2">Preterm delivery among live-born infantsb</td></tr><tr><td></td><td>n (prevalence %)</td><td>Adjusted odds ratio (95% confidence interval)</td><td>n (prevalence %)</td><td>Adjusted odds ratio (95% confidence interval)</td></tr><tr><td>Pregnancy conceived prior to SLE diagnosis</td><td>3 (0.8%)</td><td>3.1(0.5β17.9)</td><td>12 (4.7%)</td><td>1.2(0.5β2.8)</td></tr><tr><td>Pregnancy conceived after SLE diagnosis</td><td>2 (0.6%)</td><td>7.5 (0.9β62.5)</td><td>7 (2.7%)</td><td>3.4 (1.2β10.0)</td></tr></table>
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df61ecd24a6c7dcb04ddfb49db89770c1086f88b269e31f9b20e48357ccf5436.png
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simple
|
<table><tr><td>Block 1 set</td><td>Block 2 set</td><td>Block 3set</td><td>Block 4 set</td><td>Block 5 set</td><td>Block 6 set</td><td>Block 7 set</td><td>Block 8 set</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td></tr><tr><td>NT</td><td>NT</td><td>OG1</td><td>NT</td><td>NT</td><td>OG2</td><td>NT</td><td>NT</td></tr><tr><td>NT</td><td>NT</td><td>OG1</td><td>NT</td><td>NT</td><td>OG2</td><td>NT</td><td>NT</td></tr><tr><td>NT</td><td>OG2</td><td>OG1</td><td>NT</td><td>NT</td><td>OG2</td><td>OG1</td><td>NT</td></tr><tr><td>NT</td><td>OG2</td><td>NT</td><td>T(probe)</td><td>T(probe)</td><td>NT</td><td>OG1</td><td>NT</td></tr><tr><td>NT</td><td>OG2</td><td>T(probe)</td><td>NT</td><td>NT</td><td>T(probe)</td><td>OG1</td><td>NT</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td></tr><tr><td>NT</td><td>T(probe)</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT(probe)</td><td>NT</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td></tr><tr><td>PG1</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>PG2</td></tr><tr><td>PG1</td><td>T</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>T</td><td>PG2</td></tr><tr><td>PG1</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>PG2</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td></tr><tr><td>T(probe)</td><td>NT</td><td>T</td><td>NT</td><td>NT</td><td>T</td><td>NT</td><td>T(probe)</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td></tr><tr><td>NT</td><td>T</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>T</td><td>NT</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>PG2</td><td>PG1</td><td>NT</td><td>NT</td><td>NT</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>PG2</td><td>PG1</td><td>NT</td><td>NT</td><td>NT</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>PG2</td><td>PG1</td><td>NT</td><td>NT</td><td>NT</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>T(probe)</td><td>T(probe)</td><td>NT</td><td>NT</td><td>NT</td></tr><tr><td>T</td><td>NT</td><td>PG1</td><td>NT</td><td>NT</td><td>PG2</td><td>NT</td><td>T</td></tr><tr><td>NT</td><td>NT</td><td>PG1</td><td>NT</td><td>NT</td><td>PG2</td><td>NT</td><td>NT</td></tr><tr><td>NT</td><td>NT</td><td>PG1</td><td>NT</td><td>NT</td><td>PG2</td><td>NT</td><td>NT</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td></tr><tr><td>NT</td><td>NT</td><td>T(probe)</td><td>NT</td><td>NT</td><td>T(probe)</td><td>NT</td><td>NT</td></tr><tr><td>T(probe)</td><td>PG2</td><td>NT</td><td>OG2</td><td>OG1</td><td>NT</td><td>PG1</td><td>T(probe)</td></tr><tr><td>NT</td><td>PG2</td><td>NT</td><td>OG2</td><td>OG1</td><td>NT</td><td>PG1</td><td>NT</td></tr><tr><td>NT</td><td>PG2</td><td>NT</td><td>OG2</td><td>OG1</td><td>NT</td><td>PG1</td><td>NT</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td></tr><tr><td>NT</td><td>T(probe)</td><td>NT</td><td>T(probe)</td><td>T(probe)</td><td>NT</td><td>T(probe)</td><td>NT</td></tr><tr><td>OG1</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>OG2</td></tr><tr><td>OG1</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>OG2</td></tr><tr><td>OG1</td><td>NT</td><td>T</td><td>T</td><td>T</td><td>T</td><td>NT</td><td>OG2</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td></tr><tr><td>T(probe)</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>T(probe)</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td></tr><tr><td>NT</td><td>T(probe)</td><td>T(probe)</td><td>NT</td><td>NT</td><td>T(probe)</td><td>T(probe)</td><td>NT</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>T</td><td>T</td><td>NT</td><td>NT</td><td>NT</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td></tr><tr><td>T</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>T</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td></tr></table>
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<table><tr><td>Block 1 set</td><td>Block 2 set</td><td>Block 3set</td><td>Block 4 set</td><td>Block 5 set</td><td>Block 6 set</td><td>Block 7 set</td><td>Block 8 set</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td></tr><tr><td>NT</td><td>NT</td><td>OG1</td><td>NT</td><td>NT</td><td>OG2</td><td>NT</td><td>NT</td></tr><tr><td>NT</td><td>NT</td><td>OG1</td><td>NT</td><td>NT</td><td>OG2</td><td>NT</td><td>NT</td></tr><tr><td>NT</td><td>OG2</td><td>OG1</td><td>NT</td><td>NT</td><td>OG2</td><td>OG1</td><td>NT</td></tr><tr><td>NT</td><td>OG2</td><td>NT</td><td>T(probe)</td><td>T(probe)</td><td>NT</td><td>OG1</td><td>NT</td></tr><tr><td>NT</td><td>OG2</td><td>T(probe)</td><td>NT</td><td>NT</td><td>T(probe)</td><td>OG1</td><td>NT</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td></tr><tr><td>NT</td><td>T(probe)</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT(probe)</td><td>NT</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td></tr><tr><td>PG1</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>PG2</td></tr><tr><td>PG1</td><td>T</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>T</td><td>PG2</td></tr><tr><td>PG1</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>PG2</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td></tr><tr><td>T(probe)</td><td>NT</td><td>T</td><td>NT</td><td>NT</td><td>T</td><td>NT</td><td>T(probe)</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td></tr><tr><td>NT</td><td>T</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>T</td><td>NT</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>PG2</td><td>PG1</td><td>NT</td><td>NT</td><td>NT</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>PG2</td><td>PG1</td><td>NT</td><td>NT</td><td>NT</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>PG2</td><td>PG1</td><td>NT</td><td>NT</td><td>NT</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>T(probe)</td><td>T(probe)</td><td>NT</td><td>NT</td><td>NT</td></tr><tr><td>T</td><td>NT</td><td>PG1</td><td>NT</td><td>NT</td><td>PG2</td><td>NT</td><td>T</td></tr><tr><td>NT</td><td>NT</td><td>PG1</td><td>NT</td><td>NT</td><td>PG2</td><td>NT</td><td>NT</td></tr><tr><td>NT</td><td>NT</td><td>PG1</td><td>NT</td><td>NT</td><td>PG2</td><td>NT</td><td>NT</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td></tr><tr><td>NT</td><td>NT</td><td>T(probe)</td><td>NT</td><td>NT</td><td>T(probe)</td><td>NT</td><td>NT</td></tr><tr><td>T(probe)</td><td>PG2</td><td>NT</td><td>OG2</td><td>OG1</td><td>NT</td><td>PG1</td><td>T(probe)</td></tr><tr><td>NT</td><td>PG2</td><td>NT</td><td>OG2</td><td>OG1</td><td>NT</td><td>PG1</td><td>NT</td></tr><tr><td>NT</td><td>PG2</td><td>NT</td><td>OG2</td><td>OG1</td><td>NT</td><td>PG1</td><td>NT</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td></tr><tr><td>NT</td><td>T(probe)</td><td>NT</td><td>T(probe)</td><td>T(probe)</td><td>NT</td><td>T(probe)</td><td>NT</td></tr><tr><td>OG1</td><td>N</td><td>N</td><td>NT</td><td></td><td>NT</td><td>N</td><td></td></tr></table>
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<table><tr><td></td><td>T</td><td>T</td><td></td><td>NT</td><td></td><td>T</td><td>OG2</td></tr><tr><td>OG1</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>OG2</td></tr><tr><td>OG1</td><td>NT</td><td>T</td><td>T</td><td>T</td><td>T</td><td>NT</td><td>OG2</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td></tr><tr><td>T(probe)</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>T(probe)</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td></tr><tr><td>NT</td><td>T(probe)</td><td>T(probe)</td><td>NT</td><td>NT</td><td>T(probe)</td><td>T(probe)</td><td>NT</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>T</td><td>T</td><td>NT</td><td>NT</td><td>NT</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td></tr><tr><td>T</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>T</td></tr><tr><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td><td>NT</td></tr></table>
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894f0898d8fbe075d114ca40498977ed8095a69208b634eaa745284691cba930.png
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simple
|
<table><tr><td>Institutions</td><td>Key informant interview</td><td>Group Interview</td><td>Focus Group Discussion</td></tr><tr><td>National Level</td><td> </td><td> </td><td> </td></tr><tr><td><i>MoH</i></td><td>10</td><td>0</td><td>0</td></tr><tr><td><i>PMU and CCM</i></td><td>6</td><td>0</td><td>1</td></tr><tr><td><i>WHO</i></td><td>3</td><td>0</td><td>0</td></tr><tr><td><i>SRs</i></td><td>10</td><td>0</td><td>0</td></tr><tr><td><i>TAIS</i></td><td>1</td><td>0</td><td>0</td></tr><tr><td><i>CARE International</i></td><td>1</td><td>0</td><td>0</td></tr><tr><td>Districts and CHCs</td><td>8</td><td>5</td><td>6</td></tr><tr><td>Health cadres and teachers</td><td>5</td><td>1</td><td>0</td></tr><tr><td>Local Authority</td><td>5</td><td>0</td><td>0</td></tr><tr><td>Community members</td><td>0</td><td>0</td><td>9</td></tr><tr><td>SR field officers</td><td>6</td><td>2</td><td>0</td></tr><tr><td>Donors</td><td>3</td><td> </td><td> </td></tr><tr><td>Total</td><td>58</td><td>8</td><td>16</td></tr></table>
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<table><tr><td>Institutions</td><td>Key informant interview</td><td>Group Interview</td><td>Focus Group Discussion</td></tr><tr><td>National Level</td><td></td><td></td><td></td></tr><tr><td>MoH</td><td>10</td><td>0</td><td>0</td></tr><tr><td>PMU and CCM</td><td>6</td><td>0</td><td>1</td></tr><tr><td>WHO</td><td>3</td><td>0</td><td>0</td></tr><tr><td>SRs</td><td>10</td><td>0</td><td>0</td></tr><tr><td>T</td><td></td><td>0</td><td></td></tr></table>
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<table><tr><td>Institutions</td><td>Key informant interview</td><td>Group Interview</td><td>Focus Group Discussion</td></tr><tr><td>AIS</td><td>1</td><td></td><td>0</td></tr><tr><td>CARE International</td><td>1</td><td>0</td><td>0</td></tr><tr><td>Districts and CHCs</td><td>8</td><td>5</td><td>6</td></tr><tr><td>Health cadres and teachers</td><td>5</td><td>1</td><td>0</td></tr><tr><td>Local Authority</td><td>5</td><td>0</td><td>0</td></tr><tr><td>Community members</td><td>0</td><td>0</td><td>9</td></tr><tr><td>SR field officers</td><td>6</td><td>2</td><td>0</td></tr><tr><td>Donors</td><td>3</td><td></td><td></td></tr><tr><td>Total</td><td>58</td><td>8</td><td>16</td></tr></table>
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7d04e740f34fff82df1c9fcab582d43cc14969ad1e2936867ae777319d0b4fcd.png
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complex
|
<table><tr><td></td><td></td><td colspan="3">Age at infection</td><td colspan="3">Serotype<sup>a</sup></td><td colspan="3">Serologic response<sup>b</sup></td><td colspan="3">Clinical category<sup>c</sup></td></tr><tr><td></td><td>Infection order</td><td>1</td><td>2</td><td>3</td><td>1</td><td>2</td><td>3</td><td>1</td><td>2</td><td>3</td><td>1</td><td>2</td><td>3</td></tr><tr><td>Indiv.</td><td>Titers > 10<sup>d</sup></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>1</td><td>0</td><td>8.7</td><td>12.8</td><td>14.9</td><td>ND</td><td>NEG</td><td>DEN4</td><td>ND</td><td>S</td><td>S</td><td>SubC/nhDF</td><td>DHF</td><td>DHF</td></tr><tr><td>2</td><td>0</td><td>8.9</td><td>10.9</td><td>12.2</td><td>ND</td><td>ND</td><td>ND</td><td>ND</td><td>ND</td><td>ND</td><td>SubC</td><td>SubC</td><td>SubC</td></tr><tr><td>3</td><td>ND</td><td>10.5</td><td>10.8</td><td>10.9</td><td>NEG</td><td>DEN1</td><td>NEG</td><td>S</td><td>S</td><td>S</td><td>nhDF/hDF</td><td>hDF</td><td>hDF</td></tr><tr><td>4</td><td>0</td><td>7.7</td><td>8.7</td><td>11.0</td><td>ND</td><td>ND</td><td>DEN2</td><td>ND</td><td>ND</td><td>S</td><td>SubC/nhDF</td><td>SubC/nhDF</td><td>nhDF</td></tr><tr><td>5</td><td>4</td><td>7.5</td><td>8.5</td><td>10.5</td><td>ND</td><td>ND</td><td>ND</td><td>ND</td><td>ND</td><td>ND</td><td>SubC</td><td>SubC</td><td>SubC</td></tr><tr><td>6</td><td>0</td><td>7.9</td><td>9.2</td><td>12.2</td><td>ND</td><td>ND</td><td>ND</td><td>ND</td><td>ND</td><td>ND</td><td>SubC/nhDF</td><td>SubC</td><td>SubC</td></tr><tr><td>7</td><td>0</td><td>7.9</td><td>9.4</td><td>12.8</td><td>DEN1</td><td>NEG</td><td>ND</td><td>S</td><td>S</td><td>ND</td><td>DHF</td><td>nhDF</td><td>SubC</td></tr><tr><td>8</td><td>4</td><td>9.0</td><td>12.3</td><td>12.9</td><td>ND</td><td>ND</td><td>DEN2</td><td>ND</td><td>ND</td><td>S</td><td>SubC</td><td>SubC</td><td>DHF</td></tr><tr><td>9</td><td>ND</td><td>5.9</td><td>9.3</td><td>10.2</td><td>NEG</td><td>ND</td><td>ND</td><td>S</td><td>ND</td><td>ND</td><td>DHF</td><td>SubC</td><td>SubC</td></tr><tr><td>10</td><td>4</td><td>7.8</td><td>9.0</td><td>10.3</td><td>ND</td><td>ND</td><td>ND</td><td>ND</td><td>ND</td><td>ND</td><td>SubC/nhDF</td><td>SubC</td><td>SubC</td></tr><tr><td>11</td><td>ND</td><td>9.1</td><td>11.1</td><td>11.8</td><td>DEN1</td><td>DEN3</td><td>ND</td><td>S</td><td>S</td><td>ND</td><td>hDF</td><td>nhDF</td><td>SubC/nhDF</td></tr><tr><td>12</td><td>0</td><td>7.8</td><td>10.8</td><td>12.3</td><td>ND</td><td>ND</td><td>ND</td><td>ND</td><td>ND</td><td>ND</td><td>SubC/nhDF</td><td>SubC/nhDF</td><td>SubC</td></tr><tr><td>13</td><td>0</td><td>7.8</td><td>8.8</td><td>10.1</td><td>ND</td><td>ND</td><td>DEN2</td><td>ND</td><td>ND</td><td>S</td><td>SubC/nhDF</td><td>SubC/nhDF</td><td>nhDF</td></tr><tr><td>14</td><td>ND</td><td>5.3</td><td>8.7</td><td>9.8</td><td>NEG</td><td>DEN2</td><td>ND</td><td>S</td><td>S</td><td>ND</td><td>DHF</td><td>nhDF</td><td>SubC</td></tr></table>
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<table><tr><td></td><td></td><td colspan="2">Age at infection</td></tr><tr><td></td><td>Infection order</td><td>1</td><td>2</td></tr><tr><td>Indiv.</td><td>Titers > 10d</td><td></td><td></td></tr><tr><td>1</td><td>0</td><td>8.7</td><td>12.8</td></tr><tr><td>2</td><td>0</td><td>8.9</td><td>10.9</td></tr><tr><td>3</td><td>ND</td><td>10.5</td><td>10.8</td></tr><tr><td>4</td><td>0</td><td>7.7</td><td>8.7</td></tr><tr><td>5</td><td>4</td><td>7.5</td><td>8.5</td></tr><tr><td>6</td><td>0</td><td>7.9</td><td>9.2</td></tr><tr><td>7</td><td>0</td><td>7.9</td><td>9.4</td></tr><tr><td>8</td><td>4</td><td>9.0</td><td>12.3</td></tr><tr><td>9</td><td>ND</td><td>5.9</td><td>9.3</td></tr><tr><td>10</td><td>4</td><td>7.8</td><td>9.0</td></tr><tr><td>11</td><td>ND</td><td>9.1</td><td>11.1</td></tr><tr><td>12</td><td>0</td><td>7.8</td><td>10.8</td></tr><tr><td>13</td><td>0</td><td>7.8</td><td>8.8</td></tr><tr><td>14</td><td>ND</td><td>5.3</td><td>8.7</td></tr></table>
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<table><tr><td>Age at infection</td><td colspan="3">Serotypea</td><td colspan="3">Serologic responseb</td><td colspan="3">Clinical categoryc</td></tr><tr><td>3</td><td>1</td><td>2</td><td>3</td><td>1</td><td>2</td><td>3</td><td>1</td><td>2</td><td>3</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>14.9</td><td>ND</td><td>NEG</td><td>DEN4</td><td>ND</td><td>S</td><td>S</td><td>SubC/nhDF</td><td>DHF</td><td>DHF</td></tr><tr><td>12.2</td><td>ND</td><td>ND</td><td>ND</td><td>ND</td><td>ND</td><td>ND</td><td>SubC</td><td>SubC</td><td>SubC</td></tr><tr><td>10.9</td><td>NEG</td><td>DEN1</td><td>NEG</td><td>S</td><td>S</td><td>S</td><td>nhDF/hDF</td><td>hDF</td><td>hDF</td></tr><tr><td>11.0</td><td>ND</td><td>ND</td><td>DEN2</td><td>ND</td><td>ND</td><td>S</td><td>SubC/nhDF</td><td>SubC/nhDF</td><td>nhDF</td></tr><tr><td>10.5</td><td>ND</td><td>ND</td><td>ND</td><td>ND</td><td>ND</td><td>ND</td><td>SubC</td><td>SubC</td><td>SubC</td></tr><tr><td>12.2</td><td>ND</td><td>ND</td><td>ND</td><td>ND</td><td>ND</td><td>ND</td><td>SubC/nhDF</td><td>SubC</td><td>SubC</td></tr><tr><td>12.8</td><td>DEN1</td><td>NEG</td><td>ND</td><td>S</td><td>S</td><td>ND</td><td>DHF</td><td>nhDF</td><td>SubC</td></tr><tr><td>12.9</td><td>ND</td><td>ND</td><td>DEN2</td><td>ND</td><td>ND</td><td>S</td><td>SubC</td><td>SubC</td><td>DHF</td></tr><tr><td>10.2</td><td>NEG</td><td>ND</td><td>ND</td><td>S</td><td>ND</td><td>ND</td><td>DHF</td><td>SubC</td><td>SubC</td></tr><tr><td>10.3</td><td>ND</td><td>ND</td><td>ND</td><td>ND</td><td>ND</td><td>ND</td><td>SubC/nhDF</td><td>SubC</td><td>SubC</td></tr><tr><td>11.8</td><td>DEN1</td><td>DEN3</td><td>ND</td><td>S</td><td>S</td><td>ND</td><td>hDF</td><td>nhDF</td><td>SubC/nhDF</td></tr><tr><td>12.3</td><td>ND</td><td>ND</td><td>ND</td><td>ND</td><td>ND</td><td>ND</td><td>SubC/nhDF</td><td>SubC/nhDF</td><td>SubC</td></tr><tr><td>10.1</td><td>ND</td><td>ND</td><td>DEN2</td><td>ND</td><td>ND</td><td>S</td><td>SubC/nhDF</td><td>SubC/nhDF</td><td>nhDF</td></tr><tr><td>9.8</td><td>NEG</td><td>DEN2</td><td>ND</td><td>S</td><td>S</td><td>ND</td><td>DHF</td><td>nhDF</td><td>SubC</td></tr></table>
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b1379060f093b13678d63225a2b26d0a31fabf0c748bbf8728040cb896e75305.png
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complex
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<table><tr><td>Targeted Viruses</td><td>Name</td><td>Sequence of Oligonucleotide (5'–3')</td><td>Location</td><td>Amplicon Length</td></tr><tr><td rowspan="3">Hepatitis A Virus</td><td>Forward primer</td><td>GGT AGG CTA CGG GTG AAA C</td><td>393~411 <sup>a</sup></td><td rowspan="3">116 nt</td></tr><tr><td>Reverse primer</td><td>CCT CCG GCG TTG AAT GGT TT</td><td>489~508 <sup>a</sup></td></tr><tr><td>Probe</td><td>FAM-ACA GCG GCG GAT ATT GGT GAG TTG TTA AGA-BHQ</td><td>456~485 <sup>a</sup></td></tr><tr><td rowspan="3">Hepatitis E Virus</td><td>Forward primer</td><td>GGT GGT TTC TGG GGT GAC</td><td>5261~5278 <sup>b</sup></td><td rowspan="3">70 nt</td></tr><tr><td>Reverse primer</td><td>AGG GGT TGG TTG GAT GAA</td><td>5313~5330 <sup>b</sup></td></tr><tr><td>Probe</td><td>Cy5-TGA TTC TCA GCC CTT CGC-BHQ</td><td>5284~5301 <sup>b</sup></td></tr></table>
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<table><tr><td>Targeted Viruses</td><td>Name</td><td>Sequence of Oligonucleotide (5'β3')</td><td>Location</td><td>Amplicon Length</td></tr><tr><td rowspan="3">Hepatitis A Virus</td><td>Forward primer</td><td>GGT AGG CTA CGG GTG AAA C</td><td>393~411 a</td><td rowspan="3">116 nt</td></tr><tr><td>Reverse primer</td><td>CCT CCG GCG TTG AAT GGT TT</td><td>489~508 a</td></tr><tr><td>Probe</td><td>FAM-ACA GCG GCG GAT ATT GGT GAG TTG TTA AGA-BHQ</td><td>456~485 a</td></tr><tr><td rowspan="2">Hepatitis E Virus</td><td>Forward primer</td><td>GGT GGT TTC TGG GGT GAC</td><td>5261~5278 b</td><td rowspan="2">70 nt</td></tr><tr><td>Reverse primer</td><td>AGG GGT TGG TTG GAT GAA</td><td>5313~5330 b</td></tr></table>
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<table><tr><td>Hepatitis E Virus</td><td>Probe</td><td>Cy5-TGA TTC TCA GCC CTT CGC-BHQ</td><td>5284~5301 b</td><td>70 nt</td></tr></table>
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cfda2b2544476c726d8d04779f2d882df05e22c964d48eaeb151c863be613a64.png
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complex
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<table><tr><td>Variables</td><td>Group I (%)</td><td>Group II (%)</td><td><i>p</i>-value</td></tr><tr><td>Mean cardiopulmonary bypass time (minutes)</td><td>104 ± 41</td><td>98 ± 53</td><td>0.34</td></tr><tr><td>Mean aortic cross-clamping time (minutes)</td><td>82 ± 32</td><td>78 ± 37</td><td>0.41</td></tr><tr><td>Annulus enlargement</td><td>36 (13.6 %)</td><td>4 (6.9 %)</td><td>0.24</td></tr><tr><td>Mitral valve replacement</td><td>31 (11.7 %)</td><td>4 (6.9 %)</td><td>0.41</td></tr><tr><td>Coronary artery bypass grafting</td><td>37 (14 %)</td><td>7 (12 %)</td><td>0.87</td></tr><tr><td> Total grafts</td><td>66 (25 %)</td><td>12 (20.7 %)</td><td></td></tr><tr><td>Associated carotid endarterectomy</td><td>4 (1.5 %)</td><td>0</td><td>0.78</td></tr><tr><td>Tricuspid valve repair</td><td>8 (3 %)</td><td>4 (6.9 %)</td><td>0.30</td></tr><tr><td colspan="4">Postoperative outcome</td></tr><tr><td>Mean mechanical ventilation (hours)</td><td>9.8 ± 9.5</td><td>12.3 ± 14</td><td>0.10</td></tr><tr><td>Mean Intensive Care Unit stay (days)</td><td>3 ± 6.4</td><td>2.7 ± 2.6</td><td>0.73</td></tr><tr><td>Readmitted in Intensive Care Unit</td><td>8 (3 %)</td><td>3 (5.2 %)</td><td>0.68</td></tr><tr><td>Postoperative complications</td><td>52 (19.6 %)</td><td>14 (24 %)</td><td>0.55</td></tr><tr><td>Low cardiac output</td><td>39 (14.7 %)</td><td>9 (15.5 %)</td><td>0.96</td></tr><tr><td>Myocardial infarction</td><td>10 (3.8 %)</td><td>2 (3.5 %)</td><td>0.79</td></tr><tr><td>Ventricular arrhythmias</td><td>27 (10 %)</td><td>5 (8.6 %)</td><td>0.91</td></tr><tr><td>Heart Block</td><td>4 (1.5 %)</td><td>1 (1.7 %)</td><td>0.64</td></tr><tr><td>Reoperation for bleeding</td><td>15 (5.7 %)</td><td>3 (5.2 %)</td><td>0.87</td></tr><tr><td>Blood used</td><td>126 (47.6 %)</td><td>30 (52 %)</td><td>0.67</td></tr><tr><td>Pulmonary complications</td><td>17 (6.4 %)</td><td>5(8.6 %)</td><td>0.75</td></tr><tr><td> ARDS</td><td>3 (1.1 %)</td><td>1 (1.7 %)</td><td>0.78</td></tr><tr><td> Pneumonia</td><td>9 (3.4 %)</td><td>2 (3.5 %)</td><td>0.71</td></tr><tr><td>Reintubation</td><td>12 (4.5 %)</td><td>3 (5.2 %)</td><td>0.90</td></tr><tr><td>Neurological complications</td><td>9 (3.4 %)</td><td>0.33</td><td></td></tr><tr><td>Stroke</td><td>2 (0.75 %)</td><td>0</td><td>0.80</td></tr><tr><td>Infectious complications</td><td>14 (5.3 %)</td><td>4 (6.9 %)</td><td>0.87</td></tr><tr><td> Septicemia</td><td>5 (2 %)</td><td>1 (1.7 %)</td><td>0.65</td></tr><tr><td> Deep sternal wound infection</td><td>4 (1.5 %)</td><td>2 (3.5 %)</td><td>0.64</td></tr><tr><td> Superficial sternal wound infection</td><td>5 (2 %)</td><td>1 (1.7 %)</td><td>0.65</td></tr><tr><td>Renal complications</td><td>19 (7.2 %)</td><td>9 (15.5 %)</td><td>0.08</td></tr><tr><td>Hemodialysis</td><td>7 (2.6 %)</td><td>3 (5.2 %)</td><td>0.56</td></tr><tr><td>Multi organ failure</td><td>5 (2 %)</td><td>1 (1.7 %)</td><td>0.65</td></tr><tr><td>Coagulopathy</td><td>5 (2 %)</td><td>1 (1.7 %)</td><td>0.65</td></tr><tr><td>Hospital death</td><td>14 (5.3 %)</td><td>4 (6.9 %)</td><td>0.87</td></tr><tr><td> Hospital death in reoperated patients</td><td>6 (2.3 %)</td><td>2 (3.5 %)</td><td>0.22</td></tr><tr><td>Causes of hospital death</td><td></td><td></td><td></td></tr><tr><td> Cardiac</td><td>8 (3 %)</td><td>3 (5.2 %)</td><td>1.0</td></tr><tr><td> Septicemia</td><td>1 (0.4 %)</td><td>0</td><td>1.0</td></tr><tr><td> Intestinal infarction</td><td>1 (0.4 %)</td><td>0</td><td>1.0</td></tr><tr><td> Multi organ failure</td><td>3 (1.1 %)</td><td>1 (1.7 %)</td><td>1.0</td></tr><tr><td> Aortic dissection</td><td>1(0.4 %)</td><td>0</td><td>1.0</td></tr></table>
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<table><tr><td>Variables</td><td>Group I (%)</td><td>Group II (%)</td><td>p-value</td></tr><tr><td>Mean cardiopulmonary bypass time (minutes)</td><td>104 Β± 41</td><td>98 Β± 53</td><td>0.34</td></tr><tr><td>Mean aortic cross-clamping time (minutes)</td><td>82 Β± 32</td><td>78 Β± 37</td><td>0.41</td></tr><tr><td>Annulus enlargement</td><td>36 (13.6 %)</td><td>4 (6.9 %)</td><td>0.24</td></tr><tr><td>Mitral valve replacement</td><td>31 (11.7 %)</td><td>4 (6.9 %)</td><td>0.41</td></tr><tr><td>Coronary artery bypass grafting</td><td>37 (14 %)</td><td>7 (12 %)</td><td>0.87</td></tr><tr><td>Total grafts</td><td>66 (25 %)</td><td>12 (20.7 %)</td><td></td></tr><tr><td>Associated carotid endarterectomy</td><td>4 (1.5 %)</td><td>0</td><td>0.78</td></tr><tr><td>Tricuspid valve repair</td><td>8 (3 %)</td><td>4 (6.9 %)</td><td>0.30</td></tr><tr><td colspan="4">Postoperative outcome</td></tr><tr><td>Mean mechanical ventilation (hours)</td><td>9.8 Β± 9.5</td><td>12.3 Β± 14</td><td>0.10</td></tr><tr><td>Mean Intensive Care Unit stay (days)</td><td>3 Β± 6.4</td><td>2.7 Β± 2.6</td><td>0.73</td></tr><tr><td>Readmitted in Intensive Care Unit</td><td>8 (3 %)</td><td>3 (5.2 %)</td><td>0.68</td></tr><tr><td>Postoperative complications</td><td>52 (19.6 %)</td><td>14 (24 %)</td><td>0.55</td></tr><tr><td>Low cardiac output</td><td>39 (14.7 %)</td><td>9 (15.5 %)</td><td>0.96</td></tr><tr><td>Myocardial infarction</td><td>10 (3.8 %)</td><td>2 (3.5 %)</td><td>0.79</td></tr><tr><td>Ventricular arrhythmias</td><td>27 (10 %)</td><td>5 (8.6 %)</td><td>0.91</td></tr><tr><td>Heart Block</td><td>4 (1.5 %)</td><td>1 (1.7 %)</td><td>0.64</td></tr><tr><td>Reoperation for bleeding</td><td>15 (5.7 %)</td><td>3 (5.2 %)</td><td>0.87</td></tr><tr><td>Blood used</td><td>126 (47.6 %)</td><td>30 (52 %)</td><td>0.67</td></tr><tr><td>Pulmonary complications</td><td>17 (6.4 %)</td><td>5(8.6 %)</td><td>0.75</td></tr><tr><td>ARDS</td><td>3 (1.1 %)</td><td>1 (1.7 %)</td><td>0.78</td></tr><tr><td>Pneumonia</td><td>9 (3.4 %)</td><td>2 (3.5 %)</td><td>0.71</td></tr><tr><td>Reintubation</td><td>12 (4.5 %)</td><td>3 (5.2 %)</td><td>0.90</td></tr><tr><td>Neurological complications</td><td>9 (3.4 %)</td><td>0.33</td><td></td></tr><tr><td>Stroke</td><td>2 (0.75 %)</td><td>0</td><td>0.80</td></tr><tr><td>Infectious complications</td><td>14 (5.3 %)</td><td>4 (6.9 %)</td><td>0.87</td></tr><tr><td>Septicemia</td><td>5 (2 %)</td><td>1 (1.7 %)</td><td>0.65</td></tr><tr><td>Deep sternal wound infection</td><td>4 (1.5 %)</td><td>2 (3.5 %)</td><td>0.64</td></tr><tr><td>Superficial sternal wound infection</td><td>5 (2 %)</td><td>1 (1.7 %)</td><td>0.65</td></tr><tr><td>Renal complications</td><td>19 (7.2 %)</td><td>9 (15.5 %)</td><td>0.08</td></tr><tr><td>Hemodialysis</td><td>7 (2.6 %)</td><td>3 (5.2 %)</td><td>0.56</td></tr><tr><td>Multi organ failure</td><td>5 (2 %)</td><td>1 (1.7 %)</td><td>0.65</td></tr><tr><td>Coagulopathy</td><td>5 (2 %)</td><td>1 (1.7 %)</td><td>0.65</td></tr><tr><td>Hospital death</td><td>14 (5.3 %)</td><td>4 (6.9 %)</td><td>0.87</td></tr><tr><td>Hospital death in reoperated patients</td><td>6 (2.3 %)</td><td>2 (3.5 %)</td><td>0.22</td></tr><tr><td>Causes of hospital death</td><td></td><td></td><td></td></tr><tr><td>Cardiac</td><td>8 (3 %)</td><td>3 (5.2 %)</td><td>1.0</td></tr><tr><td>Septicemia</td><td>1 (0.4 %)</td><td>0</td><td>1.0</td></tr></table>
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<table><tr><td>Variables</td><td>Group I (%)</td><td>Group II (%)</td><td>p-value</td></tr><tr><td>Intestinal infarction</td><td>1 (0.4 %)</td><td>0</td><td>1.0</td></tr><tr><td>Multi organ failure</td><td>3 (1.1 %)</td><td>1 (1.7 %)</td><td>1.0</td></tr><tr><td>Aortic dissection</td><td>1(0.4 %)</td><td>0</td><td>1.0</td></tr></table>
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8b59e710408f8e698a7a2bd422725d0ed83efb2ae9d8928562c546929d214065.png
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complex
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<table><tr><td>SDQ Variables</td><td>CBCL Variables</td><td>r<sub>s</sub></td><td>p-value</td></tr><tr><td rowspan="6">Emotional symptoms</td><td>Anxiety/depression</td><td>0.480</td><td>0.002</td></tr><tr><td>Total internalizing problems</td><td>0.503</td><td>0.001</td></tr><tr><td>Attention/hyperactivity</td><td>0.412</td><td>0.008</td></tr><tr><td>Stress problem</td><td>0.546</td><td><0.001</td></tr><tr><td>Total of EB problems</td><td>0.437</td><td>0.005</td></tr><tr><td>Anxiety/depression</td><td>0.437</td><td>0.005</td></tr><tr><td rowspan="6">Conduct problems</td><td>Total internalizing problems</td><td>0.501</td><td>0.001</td></tr><tr><td>Aggressive behavior</td><td>0.600</td><td><0.001</td></tr><tr><td>Attention/hyperactivity</td><td>0.489</td><td>0.001</td></tr><tr><td>Total externalizing problems</td><td>0.675</td><td><0.001</td></tr><tr><td>Stress problem</td><td>0.637</td><td><0.001</td></tr><tr><td>Total of EB problems</td><td>0.664</td><td><0.001</td></tr><tr><td rowspan="3">Hyperactivity problem</td><td>Attention/hyperactivity</td><td>0.586</td><td><0.001</td></tr><tr><td>Stress problem</td><td>0.466</td><td>0.002</td></tr><tr><td>Total of probelms</td><td>0.401</td><td>0.010</td></tr><tr><td rowspan="4">Peer relationship problem</td><td>Anxiety/depression</td><td>0.468</td><td>0.002</td></tr><tr><td>Emotionally reactive </td><td>0.422</td><td>0.007</td></tr><tr><td>Total internalizing problems</td><td>0.474</td><td>0.002</td></tr><tr><td>Total of EB problems</td><td>0.440</td><td>0.004</td></tr><tr><td rowspan="2">Prosocial behavior</td><td>Aggressive behavior</td><td>-0.340</td><td>0.030</td></tr><tr><td>Withdrawal</td><td>-0.330</td><td>0.036</td></tr><tr><td rowspan="8">Total of difficulty</td><td>Attention/hyperactivity</td><td>0.606</td><td><0.001</td></tr><tr><td>Aggressive behavior</td><td>0.486</td><td>0.001</td></tr><tr><td>Total externalizing problems</td><td>0.595</td><td><0.001</td></tr><tr><td>Anxiety/depression</td><td>0.579</td><td>0.001</td></tr><tr><td>Emotionally reactive </td><td>0.486</td><td>0.002</td></tr><tr><td>Total internalizing problems</td><td>0.596</td><td><0.001</td></tr><tr><td>Stress problem</td><td>0.669</td><td><0.001</td></tr><tr><td>Total of EB problems</td><td>0.641</td><td>0.001</td></tr><tr><td rowspan="3">Impact of the difficulty</td><td>Aggressive behavior</td><td>0.540</td><td><0.001</td></tr><tr><td>Total externalizing EB problems</td><td>0.522</td><td><0.001</td></tr><tr><td>Total of problems</td><td>0.467</td><td>0.003</td></tr></table>
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<table><tr><td>SDQ Variables</td><td>CBCL Variables</td><td>rs</td><td>p-value</td></tr><tr><td rowspan="6">Emotional symptoms</td><td>Anxiety/depression</td><td>0.480</td><td>0.002</td></tr><tr><td>Total internalizing problems</td><td>0.503</td><td>0.001</td></tr><tr><td>Attention/hyperactivity</td><td>0.412</td><td>0.008</td></tr><tr><td>Stress problem</td><td>0.546</td><td><0.001</td></tr><tr><td>Total of EB problems</td><td>0.437</td><td>0.005</td></tr><tr><td>Anxiety/depression</td><td>0.437</td><td>0.005</td></tr><tr><td rowspan="4">Co</td><td>Total internalizing problems</td><td>0.501</td><td>0.001</td></tr><tr><td>Aggressive behavior</td><td>0.600</td><td><0.001</td></tr><tr><td>Attention/hyperactivity</td><td>0.489</td><td>0.001</td></tr><tr><td>Total externa</td><td>0.</td><td><</td></tr></table>
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<table><tr><td rowspan="3">nduct problems</td><td>lizing problems</td><td>675</td><td>0.001</td></tr><tr><td>Stress problem</td><td>0.637</td><td><0.001</td></tr><tr><td>Total of EB problems</td><td>0.664</td><td><0.001</td></tr><tr><td rowspan="3">Hyperactivity problem</td><td>Attention/hyperactivity</td><td>0.586</td><td><0.001</td></tr><tr><td>Stress problem</td><td>0.466</td><td>0.002</td></tr><tr><td>Total of probelms</td><td>0.401</td><td>0.010</td></tr><tr><td rowspan="4">Peer relationship problem</td><td>Anxiety/depression</td><td>0.468</td><td>0.002</td></tr><tr><td>Emotionally reactive</td><td>0.422</td><td>0.007</td></tr><tr><td>Total internalizing problems</td><td>0.474</td><td>0.002</td></tr><tr><td>Total of EB problems</td><td>0.440</td><td>0.004</td></tr><tr><td rowspan="2">Prosocial behavior</td><td>Aggressive behavior</td><td>-0.340</td><td>0.030</td></tr><tr><td>Withdrawal</td><td>-0.330</td><td>0.036</td></tr><tr><td rowspan="8">Total of difficulty</td><td>Attention/hyperactivity</td><td>0.606</td><td><0.001</td></tr><tr><td>Aggressive behavior</td><td>0.486</td><td>0.001</td></tr><tr><td>Total externalizing problems</td><td>0.595</td><td><0.001</td></tr><tr><td>Anxiety/depression</td><td>0.579</td><td>0.001</td></tr><tr><td>Emotionally reactive</td><td>0.486</td><td>0.002</td></tr><tr><td>Total internalizing problems</td><td>0.596</td><td><0.001</td></tr><tr><td>Stress problem</td><td>0.669</td><td><0.001</td></tr><tr><td>Total of EB problems</td><td>0.641</td><td>0.001</td></tr><tr><td rowspan="3">Impact of the difficulty</td><td>Aggressive behavior</td><td>0.540</td><td><0.001</td></tr><tr><td>Total externalizing EB problems</td><td>0.522</td><td><0.001</td></tr><tr><td>Total of problems</td><td>0.467</td><td>0.003</td></tr></table>
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624370a548427f892b708e0957a4b2178c020a26235c670f7d2c6d8578c541d7.png
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complex
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<table><tr><td rowspan="2">Clinicopathological parameters</td><td rowspan="2"><i>n</i><sup>a</sup></td><td colspan="2">ENAH expression</td><td rowspan="2">χ<sup>2</sup></td><td rowspan="2"><i>P</i> value</td></tr><tr><td>High</td><td>Low</td></tr><tr><td>All</td><td>238</td><td>136</td><td>102</td><td></td><td></td></tr><tr><td>Age (years)</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> <55</td><td>116</td><td>65</td><td>51</td><td>0.114</td><td>0.736</td></tr><tr><td> ≥55</td><td>122</td><td>71</td><td>51</td><td></td><td></td></tr><tr><td>Gender</td><td></td><td></td><td></td><td>1.021</td><td>0.312</td></tr><tr><td> Male</td><td>87</td><td>46</td><td>41</td><td></td><td></td></tr><tr><td> Female</td><td>151</td><td>90</td><td>61</td><td></td><td></td></tr><tr><td>Tumor size</td><td></td><td></td><td></td><td>15.025</td><td><0.001*</td></tr><tr><td> <3 cm</td><td>51</td><td>17</td><td>34</td><td></td><td></td></tr><tr><td> ≥3 cm</td><td>187</td><td>119</td><td>68</td><td></td><td></td></tr><tr><td>Tumor infiltration</td><td></td><td></td><td></td><td>39.028</td><td><0.001*</td></tr><tr><td> T1</td><td>41</td><td>10</td><td>31</td><td></td><td></td></tr><tr><td> T2</td><td>37</td><td>13</td><td>24</td><td></td><td></td></tr><tr><td> T3</td><td>4</td><td>2</td><td>2</td><td></td><td></td></tr><tr><td> T4a</td><td>111</td><td>82</td><td>29</td><td></td><td></td></tr><tr><td> T4b</td><td>45</td><td>29</td><td>16</td><td></td><td></td></tr><tr><td>Local lymph node metastasis</td><td></td><td></td><td></td><td>16.250</td><td>0.001*</td></tr><tr><td> N0</td><td>84</td><td>36</td><td>48</td><td></td><td></td></tr><tr><td> N1</td><td>44</td><td>23</td><td>21</td><td></td><td></td></tr><tr><td> N2</td><td>37</td><td>23</td><td>14</td><td></td><td></td></tr><tr><td> N3</td><td>73</td><td>54</td><td>19</td><td></td><td></td></tr><tr><td>Distant metastasis</td><td></td><td></td><td></td><td>0.015</td><td>0.903</td></tr><tr><td> M0</td><td>213</td><td>122</td><td>91</td><td></td><td></td></tr><tr><td> M1</td><td>25</td><td>14</td><td>11</td><td></td><td></td></tr><tr><td>TNM staging</td><td></td><td></td><td></td><td>40.926</td><td><0.001*</td></tr><tr><td> 1</td><td>48</td><td>9</td><td>39</td><td></td><td></td></tr><tr><td> 2</td><td>96</td><td>61</td><td>35</td><td></td><td></td></tr><tr><td> 3</td><td>65</td><td>50</td><td>15</td><td></td><td></td></tr><tr><td> 4</td><td>29</td><td>16</td><td>13</td><td></td><td></td></tr></table>
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<table><tr><td rowspan="2">Clinicopathological parameters</td><td rowspan="2">na</td><td colspan="2">ENAH expression</td><td rowspan="2">Ο2</td><td rowspan="2">P value</td></tr><tr><td>High</td><td>Low</td></tr><tr><td>All</td><td>238</td><td>136</td><td>102</td><td></td><td></td></tr><tr><td>Age (years)</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td><55</td><td>116</td><td>65</td><td>51</td><td>0.114</td><td>0.736</td></tr><tr><td>β₯55</td><td>122</td><td>71</td><td>51</td><td></td><td></td></tr><tr><td>Gender</td><td></td><td></td><td></td><td>1.021</td><td>0.312</td></tr><tr><td>Male</td><td>87</td><td>46</td><td>41</td><td></td><td></td></tr><tr><td>Female</td><td>151</td><td>90</td><td>61</td><td></td><td></td></tr><tr><td>Tumor size</td><td></td><td></td><td></td><td>15.025</td><td><0.001*</td></tr><tr><td><3 cm</td><td>51</td><td>17</td><td>34</td><td></td><td></td></tr><tr><td>β₯3 cm</td><td>187</td><td>119</td><td>68</td><td></td><td></td></tr><tr><td>Tumor infiltration</td><td></td><td></td><td></td><td>39.028</td><td><0.001*</td></tr><tr><td>T1</td><td>41</td><td>10</td><td>31</td><td></td><td></td></tr><tr><td>T2</td><td>37</td><td>13</td><td>24</td><td></td><td></td></tr><tr><td>T3</td><td>4</td><td>2</td><td>2</td><td></td><td></td></tr><tr><td>T4a</td><td>111</td><td>82</td><td>29</td><td></td><td></td></tr><tr><td>T4b</td><td>45</td><td>29</td><td>16</td><td></td><td></td></tr><tr><td>Local lymph node metastasis</td><td></td><td></td><td></td><td>16.250</td><td>0.001*</td></tr></table>
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<table><tr><td>N0</td><td>84</td><td>36</td><td>48</td><td></td><td></td></tr><tr><td>N1</td><td>44</td><td>23</td><td>21</td><td></td><td></td></tr><tr><td>N2</td><td>37</td><td>23</td><td>14</td><td></td><td></td></tr><tr><td>N3</td><td>73</td><td>54</td><td>19</td><td></td><td></td></tr><tr><td>Distant metastasis</td><td></td><td></td><td></td><td>0.015</td><td>0.903</td></tr><tr><td>M0</td><td>213</td><td>122</td><td>91</td><td></td><td></td></tr><tr><td>M1</td><td>25</td><td>14</td><td>11</td><td></td><td></td></tr><tr><td>TNM staging</td><td></td><td></td><td></td><td>40.926</td><td><0.001*</td></tr><tr><td>1</td><td>48</td><td>9</td><td>39</td><td></td><td></td></tr><tr><td>2</td><td>96</td><td>61</td><td>35</td><td></td><td></td></tr><tr><td>3</td><td>65</td><td>50</td><td>15</td><td></td><td></td></tr><tr><td>4</td><td>29</td><td>16</td><td>13</td><td></td><td></td></tr></table>
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36982b2e904dcb977e86b856b576311a00648f3b8b1abbff14fb0552ea62ffb3.png
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simple
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<table><tr><td>Domains</td><td>Amino acid Positions</td></tr><tr><td>PWWP1</td><td>323–388</td></tr><tr><td>NLS1</td><td>512–529</td></tr><tr><td>NLS2</td><td>1157–1174</td></tr><tr><td>NLS3</td><td>1471–1488</td></tr><tr><td>PHD1</td><td>1543–1589</td></tr><tr><td>PHD2</td><td>1590–1639</td></tr><tr><td>PHD3</td><td>1640–1693</td></tr><tr><td>PHD4</td><td>1707–1751</td></tr><tr><td>PWWP2</td><td>1756–1818</td></tr><tr><td>AWS</td><td>1890–1940</td></tr><tr><td>SET</td><td>1942–2065</td></tr><tr><td>Post-SET</td><td>2066–2082</td></tr><tr><td>PHD5</td><td>2120–2160</td></tr></table>
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<table><tr><td>Domains</td><td>Amino acid Positions</td></tr><tr><td>PWWP1</td><td>323β388</td></tr><tr><td></td><td></td></tr></table>
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<table><tr><td>Domains</td><td>Amino acid Positions</td></tr><tr><td>NLS1</td><td>512β529</td></tr><tr><td>NLS2</td><td>1157β1174</td></tr><tr><td>NLS3</td><td>1471β1488</td></tr><tr><td>PHD1</td><td>1543β1589</td></tr><tr><td>PHD2</td><td>1590β1639</td></tr><tr><td>PHD3</td><td>1640β1693</td></tr><tr><td>PHD4</td><td>1707β1751</td></tr><tr><td>PWWP2</td><td>1756β1818</td></tr><tr><td>AWS</td><td>1890β1940</td></tr><tr><td>SET</td><td>1942β2065</td></tr><tr><td>Post-SET</td><td>2066β2082</td></tr><tr><td>PHD5</td><td>2120β2160</td></tr></table>
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701c4577bccdebbb1cd2824bbac79fe4a8af8ca0da0a496f92dcb4bfe05bf46a.png
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complex
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<table><tr><td> </td><td colspan="4">Intervention departments</td><td colspan="4">Control departments</td><td>Significance tests</td></tr><tr><td> </td><td colspan="2">Baseline</td><td colspan="2">Follow-up</td><td colspan="2">Baseline</td><td colspan="2">Follow-up</td><td>Group x Time</td></tr><tr><td> </td><td colspan="2">N = 410</td><td colspan="2">N = 604</td><td colspan="2">N = 286</td><td colspan="2">N = 281</td><td>(ANOVA)</td></tr><tr><td>Indicators of patient care quality</td><td>M</td><td>SD</td><td>M</td><td>SD</td><td>M</td><td>SD</td><td>M</td><td>SD</td><td>F(df = 1); p</td></tr><tr><td>1 Organization of physicians’ care</td><td>4.20</td><td>.82</td><td>4.23</td><td>.75</td><td>4.13</td><td>.76</td><td>4.01</td><td>.84</td><td>3.67; .056†</td></tr><tr><td>2 Quality of information from physicians</td><td>4.08</td><td>.83</td><td>4.16</td><td>.77</td><td>3.88</td><td>.88</td><td>3.93</td><td>.81</td><td>0.14; n. s.</td></tr></table>
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<table><tr><td></td><td colspan="4">Intervention departments</td><td colspan="4">Control departments</td><td>Significance tests</td></tr><tr><td></td><td colspan="2">Baseline</td><td colspan="2">Follow-up</td><td colspan="2">Baseline</td><td colspan="2">Follow-up</td><td>Group x Time</td></tr><tr><td></td><td colspan="2">N = 410</td><td colspan="2">N = 604</td><td colspan="2">N = 286</td><td colspan="2">N = 281</td><td>(ANOVA)</td></tr></table>
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<table><tr><td>Indicators of patient care quality</td><td>M</td><td>SD</td><td>M</td><td>SD</td><td>M</td><td>SD</td><td>M</td><td>SD</td><td>F(df = 1); p</td></tr><tr><td>1 Organization of physiciansβ care</td><td>4.20</td><td>.82</td><td>4.23</td><td>.75</td><td>4.13</td><td>.76</td><td>4.01</td><td>.84</td><td>3.67; .056β </td></tr><tr><td>2 Quality of information from physicians</td><td>4.08</td><td>.83</td><td>4.16</td><td>.77</td><td>3.88</td><td>.88</td><td>3.93</td><td>.81</td><td>0.14; n. s.</td></tr></table>
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c8b2b6b544def33064a251b97c6a231e446e5866f4daee6521b24f9c56a61239.png
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complex
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<table><tr><td colspan="2">AEROBIC</td></tr><tr><td>Frequency:</td><td>20-60 min/day - 3-5 days/week</td></tr><tr><td>Intensity:</td><td>Light (< 40% HRR or VO2R); Moderate (40-60% HRR or VO2R); Hard (> 60% HRR or VO2R)</td></tr><tr><td>Type:</td><td>Walk or Cicle</td></tr><tr><td colspan="2">RESISTANCE</td></tr><tr><td>Frequency:</td><td>2-3x/week</td></tr><tr><td>Intensity:</td><td>Light (40-50% 1MR); Moderate (60-80% 1MR); Hard (>80% 1MR)</td></tr><tr><td>Type:</td><td>Progressive (2-4 sets; 8-15 reps; Large Muscle Groups)</td></tr><tr><td colspan="2">FLEXIBILITY</td></tr><tr><td>Frequency:</td><td>2-3x/week</td></tr><tr><td>Intensity:</td><td>10-30 sec (to the point of discomfort)</td></tr><tr><td>Type:</td><td>Static Stretching, Dynamic, and PNF, with Emphasis on Spine and Trunk</td></tr><tr><td colspan="2">BALANCE</td></tr><tr><td>Frequency:</td><td>10-15 min - 2-3x/week</td></tr><tr><td>Intensity:</td><td>There is no Evidence of the Intensity</td></tr><tr><td>Type:</td><td>Exercises Involving Motor Skills (Balance, Agility, Coordination, Gait, and Proprioception)</td></tr></table>
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<table><tr><td colspan="2">AEROBIC</td></tr><tr><td>Frequency:</td><td>20-60 min/day - 3-5 days/week</td></tr><tr><td>Intensity:</td><td>Light (< 40% HRR or VO2R); Moderate (40-60% HRR or VO2R); Hard (> 60% HRR or VO2R)</td></tr><tr><td>Type:</td><td>Walk or Cicle</td></tr></table>
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<table><tr><td colspan="2">AEROBIC</td></tr><tr><td colspan="2">RESISTANCE</td></tr><tr><td>Frequency:</td><td>2-3x/week</td></tr><tr><td>Intensity:</td><td>Light (40-50% 1MR); Moderate (60-80% 1MR); Hard (>80% 1MR)</td></tr><tr><td>Type:</td><td>Progressive (2-4 sets; 8-15 reps; Large Muscle Groups)</td></tr><tr><td colspan="2">FLEXIBILITY</td></tr><tr><td>Frequency:</td><td>2-3x/week</td></tr><tr><td>Intensity:</td><td>10-30 sec (to the point of discomfort)</td></tr><tr><td>Type:</td><td>Static Stretching, Dynamic, and PNF, with Emphasis on Spine and Trunk</td></tr><tr><td colspan="2">BALANCE</td></tr><tr><td>Frequency:</td><td>10-15 min - 2-3x/week</td></tr><tr><td>Intensity:</td><td>There is no Evidence of the Intensity</td></tr><tr><td>Type:</td><td>Exercises Involving Motor Skills (Balance, Agility, Coordination, Gait, and Proprioception)</td></tr></table>
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eab68463a0b5f05b867436882e529c5055e8d4a647e9e236f2d2b4a68e78beeb.png
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complex
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<table><tr><td> Groups</td><td colspan="2">Lung</td><td colspan="2">Lymph node</td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td> </td><td> </td><td> </td><td> </td><td> </td><td>Liver</td><td>Spleen</td><td>Kidney</td><td>Stomach</td><td>Intestine</td><td>Heart</td></tr><tr><td> </td><td>++*</td><td>+</td><td>++</td><td>+</td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>Group A</td><td>0/5</td><td>0/5</td><td>0/5</td><td>0/5</td><td>0/5</td><td>0/5</td><td>0/5</td><td>0/5</td><td>0/5</td><td>0/5</td></tr><tr><td>Group B</td><td>2/5</td><td>3/5</td><td>5/5</td><td>0/5</td><td>3/5</td><td>2/5</td><td>2/5</td><td>3/5</td><td>2/5</td><td>2/5</td></tr><tr><td>Group C</td><td>4/5</td><td>1/5</td><td>4/5</td><td>1/5</td><td>0/5</td><td>1/5</td><td>3/5</td><td>0/5</td><td>3/5</td><td>2/5</td></tr><tr><td>Group D<sup>†</sup></td><td>0/5</td><td>5/5</td><td>0/5</td><td>3/5</td><td>1/5</td><td>0/5</td><td>0/5</td><td>0/5</td><td>1/5</td><td>1/5</td></tr><tr><td>Group E</td><td>5/5</td><td>0/5</td><td>5/5</td><td>0/5</td><td>2/5</td><td>4/5</td><td>4/5</td><td>0/5</td><td>4/5</td><td>3/5</td></tr></table>
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<table><tr><td>Groups</td></tr><tr><td></td></tr><tr><td></td></tr><tr><td>Group A</td></tr><tr><td>Group B</td></tr><tr><td>Group C</td></tr><tr><td>Group Dβ </td></tr><tr><td>Group E</td></tr></table>
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<table><tr><td colspan="2">Lung</td><td colspan="2">Lymph node</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td></td><td></td><td>Liver</td><td>Spleen</td><td>Kidney</td><td>Stomach</td><td>Intestine</td><td>Heart</td></tr><tr><td>++*</td><td>+</td><td>++</td><td>+</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>0/5</td><td>0/5</td><td>0/5</td><td>0/5</td><td>0/5</td><td>0/5</td><td>0/5</td><td>0/5</td><td>0/5</td><td>0/5</td></tr><tr><td>2/5</td><td>3/5</td><td>5/5</td><td>0/5</td><td>3/5</td><td>2/5</td><td>2/5</td><td>3/5</td><td>2/5</td><td>2/5</td></tr><tr><td>4/5</td><td>1/5</td><td>4/5</td><td>1/5</td><td>0/5</td><td>1/5</td><td>3/5</td><td>0/5</td><td>3/5</td><td>2/5</td></tr><tr><td>0/5</td><td>5/5</td><td>0/5</td><td>3/5</td><td>1/5</td><td>0/5</td><td>0/5</td><td>0/5</td><td>1/5</td><td>1/5</td></tr><tr><td>5/5</td><td>0/5</td><td>5/5</td><td>0/5</td><td>2/5</td><td>4/5</td><td>4/5</td><td>0/5</td><td>4/5</td><td>3/5</td></tr></table>
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a7963892cebaca30ad24ae39dfdfcf0475a4bfd56c38f33418f330f673f1f63f.png
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complex
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<table><tr><td>Haplotype<sup>a</sup></td><td>Controls (%)</td><td colspan="3">Lung cancer</td><td colspan="3">NSCLC</td><td colspan="3">Adenocarcinoma</td></tr><tr><td></td><td></td><td>N (%)</td><td>OR (95%CI)</td><td><i>P</i></td><td>N (%)</td><td>OR (95%CI)</td><td><i>P</i></td><td>N (%)</td><td>OR (95%CI)</td><td><i>P</i></td></tr><tr><td>CC</td><td>71(7.8)</td><td>37(4.0)</td><td>0.495(0.329-0.744)</td><td><0.001<sup>*</sup></td><td>33(4.1)</td><td>0.510(0.334-0.780)</td><td>0.001<sup>*</sup></td><td>32(5.0)</td><td>0.627(0.408-0.963)</td><td>0.032<sup>*</sup></td></tr><tr><td>CT</td><td>396(43.5)</td><td>399(42.6)</td><td>0.975(0.811-1.172)</td><td>0.787</td><td>342(42.5)</td><td>0.971(0.801-1.176)</td><td>0.762</td><td>259(40.2)</td><td>0.883(0.719-1.084)</td><td>0.234</td></tr><tr><td>TC</td><td>0(--)</td><td>7(0.7)</td><td>--</td><td>--</td><td>5(0.6)</td><td>--</td><td>--</td><td>5(0.7)</td><td>--</td><td>--</td></tr><tr><td>TT</td><td>443(48.7)</td><td>493(52.7)</td><td>1.193(0.993-1.432)</td><td>0.059</td><td>424(52.7)</td><td>1.192(0.986-1.442)</td><td>0.070</td><td>348(54.1)</td><td>1.261(1.030-1.545)</td><td>0.025<sup>*</sup></td></tr></table>
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<table><tr><td>Haplotypea</td><td>Controls (%)</td><td colspan="3">Lung cancer</td><td colspan="3">NSCLC</td><td colspan="3">Adenocarcinoma</td></tr><tr><td></td><td></td><td>N (%)</td><td>OR (95%CI)</td><td>P</td><td>N (%)</td><td>OR (95%CI)</td><td>P</td><td>N (%)</td><td>OR (95%CI)</td><td>P</td></tr><tr><td>CC</td><td>71(7.8)</td><td>37(4.0)</td><td>0.495(0.329-0.744)</td><td><0.001*</td><td>33(4.1)</td><td>0.510(0.334-0.780)</td><td>0.001*</td><td>32(5.0)</td><td>0.627(0.408-0.963)</td><td>0.032*</td></tr><tr><td>CT</td><td>396(43.5)</td><td>399(42.6)</td><td>0.975(0.811-1.172)</td><td>0.787</td><td>342(42.5)</td><td>0.971(0.801-1.176)</td><td>0.762</td><td>259(40.2)</td><td>0.883(0.719-1.084)</td><td>0.234</td></tr></table>
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<table><tr><td>Haplotypea</td><td>Controls (%)</td><td colspan="3">Lung cancer</td><td colspan="3">NSCLC</td><td colspan="3">Adenocarcinoma</td></tr><tr><td></td><td></td><td>N (%)</td><td>OR (95%CI)</td><td>P</td><td>N (%)</td><td>OR (95%CI)</td><td>P</td><td>N (%)</td><td>OR (95%CI)</td><td>P</td></tr><tr><td>TC</td><td>0(--)</td><td>7(0.7)</td><td>--</td><td>--</td><td>5(0.6)</td><td>--</td><td>--</td><td>5(0.7)</td><td>--</td><td>--</td></tr><tr><td>TT</td><td>443(48.7)</td><td>493(52.7)</td><td>1.193(0.993-1.432)</td><td>0.059</td><td>424(52.7)</td><td>1.192(0.986-1.442)</td><td>0.070</td><td>348(54.1)</td><td>1.261(1.030-1.545)</td><td>0.025*</td></tr></table>
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a411a26014323c8d1c1cc4adb4e3ebb5116cf7fa9d7a2085f71e33b89ec56e90.png
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complex
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<table><tr><td>DATASET</td><td>ALL</td><td>GA-FS</td><td>H-MTL</td><td>GA-MTL</td><td>GA-MTL-IR</td><td>e-GA-MTL</td></tr><tr><td colspan="7"><i>M</i> = 2 for ANN</td></tr><tr><td>Breast</td><td>53.1(9.5)</td><td>56.3(8.4)</td><td>59.3(8.8)</td><td>71.9(8.9)</td><td>68.8(8.1)</td><td>71.9(8.6)</td></tr><tr><td>Colon</td><td>57.1(7.8)</td><td>61.9(7.3)</td><td>66.6(7.1)</td><td>80.9(6.3)</td><td>85.7(6.4)</td><td>80.9(6.4)</td></tr><tr><td>Leukemia</td><td>57.7(9.3)</td><td>53.8(9.0)</td><td>61.5(9.5)</td><td>76.9(8.4)</td><td>76.9(9.1)</td><td>80.7(8.9)</td></tr><tr><td>Ovarian</td><td>57.1(6.4)</td><td>67.9(7.4)</td><td>75.0(5.4)</td><td>78.6(5.9)</td><td>79.8(5.1)</td><td>82.1(5.8)</td></tr><tr><td>Average</td><td>56.3(8.3)</td><td>60.0(8.0)</td><td>65.6(7.7)</td><td>77.1(7.4)</td><td>77.8(7.2)</td><td>78.9(7.4)</td></tr><tr><td colspan="7"><i>M</i> = 10 for ANN</td></tr><tr><td>Breast</td><td>64.3(8.5)</td><td>67.3(8.7)</td><td>65.7(8.3)</td><td>75.4(8.3)</td><td>71.8(7.5)</td><td>75.8(8.0)</td></tr><tr><td>Colon</td><td>62.0(7.5)</td><td>71.2(7.2)</td><td>75.2(6.5)</td><td>85.1(6.7)</td><td>82.9(6.1)</td><td>83.9(6.3)</td></tr><tr><td>Leukemia</td><td>65.3(8.8)</td><td>69.2(8.4)</td><td>76.3(8.8)</td><td>84.6(8.9)</td><td>83.1(8.1)</td><td>85.6(8.3)</td></tr><tr><td>Ovarian</td><td>61.9(7.5)</td><td>65.4(7.7)</td><td>78.6(6.4)</td><td>80.9(6.8)</td><td>82.1(6.4)</td><td>83.3(6.8)</td></tr><tr><td>Average</td><td>63.4(8.1)</td><td>68.3(8.0)</td><td>74.0(7.5)</td><td>81.5(7.7)</td><td>80.0(7.0)</td><td>82.2(7.4)</td></tr></table>
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<table><tr><td>DATASET</td><td>ALL</td><td>GA-FS</td><td>H-MTL</td><td>GA-MTL</td><td>GA-MTL-IR</td><td>e-GA-MTL</td></tr><tr><td colspan="7">M = 2 for ANN</td></tr><tr><td>Breast</td><td>53.1(9.5)</td><td>56.3(8.4)</td><td>59.3(8.8)</td><td>71.9(8.9)</td><td>68.8(8.1)</td><td>71.9(8.6)</td></tr><tr><td>Colon</td><td>57.1(7.8)</td><td>61.9(7.3)</td><td>66.6(7.1)</td><td>80.9(6.3)</td><td>85.7(6.4)</td><td>80.9(6.4)</td></tr><tr><td>Le</td><td>57.7(9.</td><td>53.8(</td><td>61.5(9.5</td><td>76.9(</td><td>76.9(9.</td><td>8</td></tr></table>
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<table><tr><td>DATASET</td><td>ALL</td><td>GA-FS</td><td>H-MTL</td><td>GA-MTL</td><td>GA-MTL-IR</td><td>e-GA-MTL</td></tr><tr><td>ukemia</td><td>3)</td><td>9.0)</td><td>)</td><td>8.4)</td><td>1)</td><td>0.7(8.9)</td></tr><tr><td>Ovarian</td><td>57.1(6.4)</td><td>67.9(7.4)</td><td>75.0(5.4)</td><td>78.6(5.9)</td><td>79.8(5.1)</td><td>82.1(5.8)</td></tr><tr><td>Average</td><td>56.3(8.3)</td><td>60.0(8.0)</td><td>65.6(7.7)</td><td>77.1(7.4)</td><td>77.8(7.2)</td><td>78.9(7.4)</td></tr><tr><td colspan="7">M = 10 for ANN</td></tr><tr><td>Breast</td><td>64.3(8.5)</td><td>67.3(8.7)</td><td>65.7(8.3)</td><td>75.4(8.3)</td><td>71.8(7.5)</td><td>75.8(8.0)</td></tr><tr><td>Colon</td><td>62.0(7.5)</td><td>71.2(7.2)</td><td>75.2(6.5)</td><td>85.1(6.7)</td><td>82.9(6.1)</td><td>83.9(6.3)</td></tr><tr><td>Leukemia</td><td>65.3(8.8)</td><td>69.2(8.4)</td><td>76.3(8.8)</td><td>84.6(8.9)</td><td>83.1(8.1)</td><td>85.6(8.3)</td></tr><tr><td>Ovarian</td><td>61.9(7.5)</td><td>65.4(7.7)</td><td>78.6(6.4)</td><td>80.9(6.8)</td><td>82.1(6.4)</td><td>83.3(6.8)</td></tr><tr><td>Average</td><td>63.4(8.1)</td><td>68.3(8.0)</td><td>74.0(7.5)</td><td>81.5(7.7)</td><td>80.0(7.0)</td><td>82.2(7.4)</td></tr></table>
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e5efffba4e91bddc1255c0c61c9089d62f84250d02c954465a1edc39f4d20f2b.png
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complex
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<table><tr><td></td><td colspan="4">Transplanted organ (n)</td><td colspan="5">EAS characteristics and outcomes</td></tr><tr><td>Authors, Year</td><td>Liver</td><td>Heart</td><td>Lung</td><td>Kidney</td><td>Patients undergoing EAS (n)</td><td>EAS Rate (%)</td><td>Surgical procedures (n)</td><td>Morbidity [n (%)]</td><td>Mortality [n (%)]</td></tr><tr><td>Cruz RJ Jr et al., 2012 [26]</td><td>5677</td><td></td><td></td><td></td><td>7</td><td>0,12</td><td>BR (7)</td><td>n/a</td><td>2 (28.6)</td></tr><tr><td>Lahon B et al., 2011 [13]</td><td></td><td></td><td>351</td><td></td><td>3</td><td>0.85</td><td>BR (3)</td><td>n/a</td><td>0 (0)</td></tr><tr><td>Paul S et al., 2009 [4]</td><td></td><td></td><td>208</td><td></td><td>14</td><td>6.73</td><td>LA (14)</td><td>n/a</td><td>1 (7.1)</td></tr><tr><td>Miller CB et al., 2006 [41]</td><td></td><td></td><td>229</td><td></td><td>2</td><td>0.87</td><td>BR (1), LA (1)</td><td>n/a</td><td>1 (50)</td></tr><tr><td>Karakayali H et al., 2002 [32]</td><td></td><td></td><td></td><td>1038</td><td>1</td><td>0.10</td><td>BR (1)</td><td>n/a</td><td>0 (0)</td></tr><tr><td>Andreoni KA et al., 1999 [33]</td><td></td><td></td><td></td><td>1417</td><td>4</td><td>0.28</td><td>BR (4)</td><td>n/a</td><td>1 (25)</td></tr><tr><td>Bhatia DS et al., 1997 [21]</td><td></td><td>349</td><td></td><td></td><td>5</td><td>1.43</td><td>BR (5)</td><td>1 (20)</td><td>0</td></tr><tr><td>Total</td><td>5677</td><td>349</td><td>788</td><td>2455</td><td>36</td><td>0.39</td><td>BR (21), LA (15)</td><td>n/a</td><td>5 (13.9)</td></tr></table>
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<table><tr><td></td><td colspan="4">Transplanted organ (n)</td><td colspan="5">EAS characteristics and outcomes</td></tr><tr><td>Authors, Year</td><td>Liver</td><td>Heart</td><td>Lung</td><td>Kidney</td><td>Patients undergoing EAS (n)</td><td>EAS Rate (%)</td><td>Surgical procedures (n)</td><td>Morbidity [n (%)]</td><td>Mortality [n (%)]</td></tr><tr><td>Cruz RJ Jr et al., 2012 [26]</td><td>5677</td><td></td><td></td><td></td><td>7</td><td>0,12</td><td>BR (7)</td><td>n/a</td><td>2 (28.6)</td></tr><tr><td>Lahon B et al., 2011 [13]</td><td></td><td></td><td>351</td><td></td><td>3</td><td>0.85</td><td>BR (3)</td><td>n/a</td><td>0 (0)</td></tr><tr><td>Paul S </td><td></td><td></td><td>20</td><td></td><td></td><td></td><td></td><td>n</td><td></td></tr></table>
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<table><tr><td></td><td colspan="4">Transplanted organ (n)</td><td colspan="5">EAS characteristics and outcomes</td></tr><tr><td>Authors, Year</td><td>Liver</td><td>Heart</td><td>Lung</td><td>Kidney</td><td>Patients undergoing EAS (n)</td><td>EAS Rate (%)</td><td>Surgical procedures (n)</td><td>Morbidity [n (%)]</td><td>Mortality [n (%)]</td></tr><tr><td>et al., 2009 [4]</td><td></td><td></td><td>8</td><td></td><td>14</td><td>6.73</td><td>LA (14)</td><td>/a</td><td>1 (7.1)</td></tr><tr><td>Miller CB et al., 2006 [41]</td><td></td><td></td><td>229</td><td></td><td>2</td><td>0.87</td><td>BR (1), LA (1)</td><td>n/a</td><td>1 (50)</td></tr><tr><td>Karakayali H et al., 2002 [32]</td><td></td><td></td><td></td><td>1038</td><td>1</td><td>0.10</td><td>BR (1)</td><td>n/a</td><td>0 (0)</td></tr><tr><td>Andreoni KA et al., 1999 [33]</td><td></td><td></td><td></td><td>1417</td><td>4</td><td>0.28</td><td>BR (4)</td><td>n/a</td><td>1 (25)</td></tr><tr><td>Bhatia DS et al., 1997 [21]</td><td></td><td>349</td><td></td><td></td><td>5</td><td>1.43</td><td>BR (5)</td><td>1 (20)</td><td>0</td></tr><tr><td>Total</td><td>5677</td><td>349</td><td>788</td><td>2455</td><td>36</td><td>0.39</td><td>BR (21), LA (15)</td><td>n/a</td><td>5 (13.9)</td></tr></table>
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d9d92c6a1827de3c7d24b3a933e888952e763a1fd2cd1557150699be1425a965.png
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simple
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<table><tr><td> </td><td>Women</td><td> </td><td>Test for group difference</td><td>Sign.</td><td>Effect size</td><td>Men</td><td> </td><td>Test for group difference</td><td>Sign.</td><td>Effect size</td></tr><tr><td>Subscale</td><td><i>n</i></td><td><i>M(SD)</i></td><td><i>t</i></td><td><i>p</i></td><td><i>d</i></td><td><i>n</i></td><td><i>M(SD)</i></td><td><i>t</i></td><td><i>p</i></td><td><i>d</i></td></tr><tr><td>Sexual desire/frequency</td><td> </td><td> </td><td>21.28</td><td><0.001</td><td>1.403</td><td> </td><td> </td><td>8.73</td><td><0.001</td><td>1.388</td></tr><tr><td> Before cancer</td><td>520</td><td>6.85 (1.64)</td><td> </td><td> </td><td> </td><td>117</td><td>7.40 (1.33)</td><td> </td><td> </td><td> </td></tr><tr><td> After cancer</td><td>520</td><td>4.92 (1.86)</td><td> </td><td> </td><td> </td><td>117</td><td>5.86 (1.97)</td><td> </td><td> </td><td> </td></tr><tr><td>Sexual desire/interest</td><td> </td><td> </td><td>16.63</td><td><0.001</td><td>1.228</td><td> </td><td> </td><td>6.75</td><td><0.001</td><td>1.285</td></tr><tr><td> Before cancer</td><td>516</td><td>8.82 (2.51)</td><td> </td><td> </td><td> </td><td>115</td><td>10.74 (2.12)</td><td> </td><td> </td><td> </td></tr><tr><td> After cancer</td><td>516</td><td>6.77 (2.62)</td><td> </td><td> </td><td> </td><td>115</td><td>9.17 (2.44)</td><td> </td><td> </td><td> </td></tr><tr><td>Sexual arousal</td><td> </td><td> </td><td>21.01</td><td><0.001</td><td>1.459</td><td> </td><td> </td><td>16.96</td><td><0.001</td><td>1.807</td></tr><tr><td> Before cancer</td><td>509</td><td>11.17 (3.01)</td><td> </td><td> </td><td> </td><td>114</td><td>13.69 (1.42)</td><td> </td><td> </td><td> </td></tr><tr><td> After cancer</td><td>509</td><td>7.27 (3.12)</td><td> </td><td> </td><td> </td><td>114</td><td>9.26 (2.52)</td><td> </td><td> </td><td> </td></tr><tr><td>Sexual orgasm</td><td> </td><td> </td><td>18.13</td><td><0.001</td><td>1.342</td><td> </td><td> </td><td>16.32</td><td><0.001</td><td>1.924</td></tr><tr><td> Before cancer</td><td>504</td><td>12.04 (2.95)</td><td> </td><td> </td><td> </td><td>109</td><td>12.29 (1.90)</td><td> </td><td> </td><td> </td></tr><tr><td> After cancer</td><td>504</td><td>8.72 (3.97)</td><td> </td><td> </td><td> </td><td>109</td><td>6.88 (3.32)</td><td> </td><td> </td><td> </td></tr><tr><td>Total sexual functioning</td><td> </td><td> </td><td>13.67</td><td><0.001</td><td>1.359</td><td> </td><td> </td><td>10.49</td><td><0.001</td><td>1.547</td></tr><tr><td> Before cancer</td><td>446</td><td>42.22 (7.37)</td><td> </td><td> </td><td> </td><td>104</td><td>46.55 (5.36)</td><td> </td><td> </td><td> </td></tr><tr><td> After cancer</td><td>446</td><td>34.73(10.45)</td><td> </td><td> </td><td> </td><td>104</td><td>36.48 (9.30)</td><td> </td><td> </td><td> </td></tr></table>
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<table><tr><td></td><td>Women</td><td></td><td>Test for group difference</td><td>Sign.</td><td>Effect size</td><td>Men</td><td></td><td>Test for group difference</td><td>Sign.</td><td>Effect size</td></tr><tr><td>Subscale</td><td>n</td><td>M(SD)</td><td>t</td><td>p</td><td>d</td><td>n</td><td>M(SD)</td><td>t</td><td>p</td><td>d</td></tr><tr><td>Sexual desire/frequency</td><td></td><td></td><td>21.28</td><td><0.001</td><td>1.403</td><td></td><td></td><td>8.73</td><td><0.001</td><td>1.388</td></tr><tr><td>Before cancer</td><td>520</td><td>6.85 (1.64)</td><td></td><td></td><td></td><td>117</td><td>7.40 (1.33)</td><td></td><td></td><td></td></tr><tr><td>After cancer</td><td>520</td><td>4.92 (1.86)</td><td></td><td></td><td></td><td>117</td><td>5.86 (1.97)</td><td></td><td></td><td></td></tr><tr><td>Sexual desire/interest</td><td></td><td></td><td>16.63</td><td><0.001</td><td>1.228</td><td></td><td></td><td>6.75</td><td><0.001</td><td>1.285</td></tr><tr><td>Before cancer</td><td>516</td><td>8.82 (2.51)</td><td></td><td></td><td></td><td>115</td><td>10.74 (2.12)</td><td></td><td></td><td></td></tr><tr><td>After cancer</td><td>516</td><td>6.77 (2.62)</td><td></td><td></td><td></td><td>115</td><td>9.17 (2.44)</td><td></td><td></td><td></td></tr></table>
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<table><tr><td>Sexual arousal</td><td></td><td></td><td>21.01</td><td><0.001</td><td>1.459</td><td></td><td></td><td>16.96</td><td><0.001</td><td>1.807</td></tr><tr><td>Before cancer</td><td>509</td><td>11.17 (3.01)</td><td></td><td></td><td></td><td>114</td><td>13.69 (1.42)</td><td></td><td></td><td></td></tr><tr><td>After cancer</td><td>509</td><td>7.27 (3.12)</td><td></td><td></td><td></td><td>114</td><td>9.26 (2.52)</td><td></td><td></td><td></td></tr><tr><td>Sexual orgasm</td><td></td><td></td><td>18.13</td><td><0.001</td><td>1.342</td><td></td><td></td><td>16.32</td><td><0.001</td><td>1.924</td></tr><tr><td>Before cancer</td><td>504</td><td>12.04 (2.95)</td><td></td><td></td><td></td><td>109</td><td>12.29 (1.90)</td><td></td><td></td><td></td></tr><tr><td>After cancer</td><td>504</td><td>8.72 (3.97)</td><td></td><td></td><td></td><td>109</td><td>6.88 (3.32)</td><td></td><td></td><td></td></tr><tr><td>Total sexual functioning</td><td></td><td></td><td>13.67</td><td><0.001</td><td>1.359</td><td></td><td></td><td>10.49</td><td><0.001</td><td>1.547</td></tr><tr><td>Before cancer</td><td>446</td><td>42.22 (7.37)</td><td></td><td></td><td></td><td>104</td><td>46.55 (5.36)</td><td></td><td></td><td></td></tr><tr><td>After cancer</td><td>446</td><td>34.73(10.45)</td><td></td><td></td><td></td><td>104</td><td>36.48 (9.30)</td><td></td><td></td><td></td></tr></table>
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c8b7127c98749d4b03378d1f949d306da2ba62a69b369543752c155e221074cd.png
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simple
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<table><tr><td>ABC subfamily</td><td><i>Bombyx mori</i></td><td><i>Drosophila melanogaster</i></td><td><i>Anopheles gambiae</i></td><td><i>Tribilium castaneum</i></td><td><i>Apis mellifera</i></td><td><i>Homo sapiens</i></td></tr><tr><td>A</td><td>6</td><td>10</td><td>9</td><td>9</td><td>3</td><td>13</td></tr><tr><td>B</td><td>8</td><td>8</td><td>5</td><td>6</td><td>7</td><td>11</td></tr><tr><td>C</td><td>15</td><td>14</td><td>13</td><td>31</td><td>9</td><td>12</td></tr><tr><td>D</td><td>2</td><td>2</td><td>2</td><td>2</td><td>2</td><td>4</td></tr><tr><td>E</td><td>1</td><td>1</td><td>1</td><td>1</td><td>1</td><td>1</td></tr><tr><td>F</td><td>3</td><td>3</td><td>3</td><td>3</td><td>3</td><td>3</td></tr><tr><td>G</td><td>13</td><td>15</td><td>16</td><td>13</td><td>15</td><td>5</td></tr><tr><td>H</td><td>3</td><td>3</td><td>3</td><td>3</td><td>3</td><td>0</td></tr><tr><td>Total</td><td>51</td><td>56</td><td>52</td><td>68</td><td>43</td><td>48</td></tr></table>
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<table><tr><td>ABC subfamily</td><td>Bombyx mori</td><td>Drosophila melanogaster</td><td>Anopheles gambiae</td><td>Tribilium castaneum</td><td>Apis mellifera</td><td>Homo sapiens</td></tr><tr><td>A</td><td>6</td><td>10</td><td>9</td><td>9</td><td>3</td><td>13</td></tr><tr><td>B</td><td>8</td><td>8</td><td>5</td><td>6</td><td>7</td><td>11</td></tr><tr><td>C</td><td>15</td><td>14</td><td>13</td><td>31</td><td>9</td><td>12</td></tr><tr><td>D</td><td>2</td><td></td><td></td><td>2</td><td></td><td></td></tr></table>
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<table><tr><td>ABC subfamily</td><td>Bombyx mori</td><td>Drosophila melanogaster</td><td>Anopheles gambiae</td><td>Tribilium castaneum</td><td>Apis mellifera</td><td>Homo sapiens</td></tr><tr><td></td><td></td><td>2</td><td>2</td><td></td><td>2</td><td>4</td></tr><tr><td>E</td><td>1</td><td>1</td><td>1</td><td>1</td><td>1</td><td>1</td></tr><tr><td>F</td><td>3</td><td>3</td><td>3</td><td>3</td><td>3</td><td>3</td></tr><tr><td>G</td><td>13</td><td>15</td><td>16</td><td>13</td><td>15</td><td>5</td></tr><tr><td>H</td><td>3</td><td>3</td><td>3</td><td>3</td><td>3</td><td>0</td></tr><tr><td>Total</td><td>51</td><td>56</td><td>52</td><td>68</td><td>43</td><td>48</td></tr></table>
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57899e88750309d97d02d38983f83c16d06fb479d72bed5e64f558782c1960c4.png
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complex
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<table><tr><td></td><td colspan="5">Intervention villages</td><td>Control village</td></tr><tr><td></td><td> Village 12</td><td>Village13</td><td>Village 14</td><td>Village15</td><td>Total</td><td>Chikore</td></tr><tr><td><i>S. haematobium</i></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> Number positive</td><td>5</td><td>5</td><td>4</td><td>8</td><td>22</td><td>10</td></tr><tr><td> Number negative</td><td>98</td><td>58</td><td>42</td><td>57</td><td>255</td><td>69</td></tr><tr><td> Prevalence</td><td>4.9%</td><td>7.9%</td><td>8.7%</td><td>12.3</td><td>7.9%</td><td>12.7%</td></tr><tr><td><i>S. mansoni</i></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> Number positive</td><td>0</td><td>3</td><td>3</td><td>3</td><td>9</td><td>No data</td></tr><tr><td> Number negative</td><td>103</td><td>60</td><td>43</td><td>62</td><td>268</td><td>No data</td></tr><tr><td> Prevalence</td><td>0</td><td>4.8</td><td>6.5</td><td>4.6</td><td>3.4%</td><td>No data</td></tr></table>
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<table><tr><td></td><td colspan="5">Intervention villages</td><td>Control village</td></tr><tr><td></td><td>Village 12</td><td>Village13</td><td>Village 14</td><td>Village15</td><td>Total</td><td>Chikore</td></tr><tr><td>S. haematobium</td><td></td><td></td><td></td><td></td><td></td><td></td></tr></table>
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<table><tr><td>Number positive</td><td>5</td><td>5</td><td>4</td><td>8</td><td>22</td><td>10</td></tr><tr><td>Number negative</td><td>98</td><td>58</td><td>42</td><td>57</td><td>255</td><td>69</td></tr><tr><td>Prevalence</td><td>4.9%</td><td>7.9%</td><td>8.7%</td><td>12.3</td><td>7.9%</td><td>12.7%</td></tr><tr><td>S. mansoni</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Number positive</td><td>0</td><td>3</td><td>3</td><td>3</td><td>9</td><td>No data</td></tr><tr><td>Number negative</td><td>103</td><td>60</td><td>43</td><td>62</td><td>268</td><td>No data</td></tr><tr><td>Prevalence</td><td>0</td><td>4.8</td><td>6.5</td><td>4.6</td><td>3.4%</td><td>No data</td></tr></table>
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d9706a2c893b6d695cdd96b79dc8cb35cea52d73e9ac8cf7e81083e1c5716c85.png
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simple
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<table><tr><td>Strategy</td><td>Cost</td><td>Incremental cost</td><td>Live births</td><td>Cost per live birth</td><td>ICER vs. eS ET</td><td>ICER vs Embry Dx SET</td></tr><tr><td>eSET</td><td>€14,896</td><td>-</td><td>0.314</td><td> €47,439</td><td></td><td></td></tr><tr><td>Embryo-Dx SET</td><td>€16,687</td><td>€1,791</td><td>0.43</td><td> €38,807</td><td>€15,439</td><td></td></tr><tr><td>DET</td><td>€18,952</td><td>€2,265</td><td>0.473</td><td> €40,068</td><td>€25,509</td><td>€52,674</td></tr><tr><td></td><td></td><td><i>€4,056‡</i></td><td></td><td></td><td></td><td></td></tr></table>
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<table><tr><td>Strategy</td><td>Cost</td><td>Incremental cost</td><td>Live births</td><td>Cost per live birth</td><td>ICER vs. eS ET</td><td>ICER vs Embry Dx SET</td></tr></table>
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<table><tr><td>eSET</td><td>β¬14,896</td><td>-</td><td>0.314</td><td>β¬47,439</td><td></td><td></td></tr><tr><td>Embryo-Dx SET</td><td>β¬16,687</td><td>β¬1,791</td><td>0.43</td><td>β¬38,807</td><td>β¬15,439</td><td></td></tr><tr><td>DET</td><td>β¬18,952</td><td>β¬2,265</td><td>0.473</td><td>β¬40,068</td><td>β¬25,509</td><td>β¬52,674</td></tr><tr><td></td><td></td><td>β¬4,056β‘</td><td></td><td></td><td></td><td></td></tr></table>
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621f19f6c33a9dd815b6a85337c140feb6356ebef8d286cea86668486dcc6e5a.png
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complex
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<table><tr><td>Dataset</td><td>SNVSniffer(M1)</td><td>VarScan2</td><td>SomaticSniper</td><td>JSM2</td><td>MuTect</td></tr><tr><td colspan="4">Sensitivity (%)</td><td colspan="2"></td></tr><tr><td>T1</td><td>66.86</td><td>38.29</td><td>61.148</td><td>0.001</td><td>91.43</td></tr><tr><td>T2</td><td>82.35</td><td>35.29</td><td>63.73</td><td>0.00</td><td>93.14</td></tr><tr><td>T3</td><td>72.36</td><td>59.35</td><td>75.61</td><td>0.00</td><td>95.93</td></tr><tr><td>T4</td><td>93.55</td><td>83.87</td><td>87.10</td><td>0.00</td><td>96.77</td></tr><tr><td>T5</td><td>75.00</td><td>43.75</td><td>68.75</td><td>0.00</td><td>97.92</td></tr><tr><td colspan="4">Time (h)</td><td colspan="2"></td></tr><tr><td>T1</td><td>2.67</td><td>5.75</td><td>1.58</td><td>10.41</td><td>22.87</td></tr><tr><td>T2</td><td>2.56</td><td>4.73</td><td>1.33</td><td>9.48</td><td>19.37</td></tr><tr><td>T3</td><td>2.41</td><td>4.30</td><td>1.34</td><td>7.39</td><td>19.27</td></tr><tr><td>T4</td><td>2.91</td><td>5.26</td><td>1.39</td><td>10.00</td><td>24.16</td></tr><tr><td>T5</td><td>2.87</td><td>4.75</td><td>1.55</td><td>8.11</td><td>20.50</td></tr></table>
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<table><tr><td>Dataset</td><td>SNVSniffer(M1)</td><td>VarScan2</td><td>SomaticSniper</td><td>JSM2</td><td>MuTect</td></tr><tr><td colspan="4">Sensitivity (%)</td><td colspan="2"></td></tr><tr><td>T1</td><td>66.86</td><td>38.29</td><td>61.148</td><td>0.001</td><td>91.43</td></tr><tr><td>T2</td><td>82.35</td><td>35.29</td><td>63.73</td><td>0.00</td><td>93.14</td></tr><tr><td>T3</td><td>72.36</td><td>59.35</td><td>75.61</td><td>0.00</td><td>95.93</td></tr><tr><td>T4</td><td>93.55</td><td>83.87</td><td>87.10</td><td>0.00</td><td>96.77</td></tr><tr><td>T5</td><td>75.00</td><td>43.75</td><td>68.75</td><td>0.00</td><td>97.92</td></tr><tr><td colspan="4">Time (h)</td><td colspan="2"></td></tr><tr><td>T1</td><td>2.67</td><td>5.75</td><td>1.58</td><td>10.41</td><td>22.87</td></tr><tr><td>T2</td><td>2.56</td><td>4.73</td><td>1.33</td><td>9.48</td><td>19.37</td></tr></table>
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<table><tr><td>Dataset</td><td>SNVSniffer(M1)</td><td>VarScan2</td><td>SomaticSniper</td><td>JSM2</td><td>MuTect</td></tr><tr><td>T3</td><td>2.41</td><td>4.30</td><td>1.34</td><td>7.39</td><td>19.27</td></tr><tr><td>T4</td><td>2.91</td><td>5.26</td><td>1.39</td><td>10.00</td><td>24.16</td></tr><tr><td>T5</td><td>2.87</td><td>4.75</td><td>1.55</td><td>8.11</td><td>20.50</td></tr></table>
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1eab9e608dce0b02c2d5a5cf63c35c98f4295d3b30f93113aee6d8b706b90b56.png
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simple
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<table><tr><td>Maternal Characteristics</td><td><i>n</i> Without Missing Information</td><td>Adolescents <i>n</i> (%)</td><td>Adult Women <i>n</i> (%)</td><td><i>p</i>-Value *</td></tr><tr><td>Late antenatal visit</td><td>42,855</td><td>614 (30.7)</td><td>5148 (12.6)</td><td><0.001</td></tr><tr><td>BMI, kg/m<sup>2</sup></td><td>42,751</td><td></td><td></td><td><0.001</td></tr><tr><td><18.5</td><td></td><td>219 (11.0)</td><td>2604 (6.4)</td><td></td></tr><tr><td>18.5–24.9</td><td></td><td>1465 (73.3)</td><td>25,985 (63.8)</td><td></td></tr><tr><td>≥25</td><td></td><td>314 (15.7)</td><td>12,164 (29.8)</td><td></td></tr><tr><td>Smoking</td><td>39,888</td><td>604 (31.6)</td><td>5875 (15.5)</td><td><0.001</td></tr><tr><td>Evidence of alcohol abuse</td><td>43,318</td><td>7 (0.3)</td><td>171 (0.4)</td><td>0.631</td></tr><tr><td>Evidence of drug abuse</td><td>43,320</td><td>0 (0.0)</td><td>14 (0.0)</td><td>0.406</td></tr><tr><td>Folic acid intake</td><td>43,191</td><td>866 (42.9)</td><td>22,117 (53.7)</td><td><0.001</td></tr><tr><td>Multivitamin intake</td><td>43,192</td><td>961 (47.6)</td><td>22,332 (54.2)</td><td><0.001</td></tr><tr><td>Infections of kidney in pregnancy <sup>1</sup></td><td>43,327</td><td>762 (37.5)</td><td>13,980 (33.9)</td><td>0.001</td></tr><tr><td>Infections of the genital tract in pregnancy <sup>2</sup></td><td>43,327</td><td>495 (24.3)</td><td>6600 (16.0)</td><td><0.001</td></tr><tr><td>Parity (para)</td><td>39,249</td><td>160 (8.9)</td><td>21,553 (57.6)</td><td><0.001</td></tr></table>
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<table><tr><td>Maternal Characteristics</td><td>n Without Missing Information</td><td>Adolescents n (%)</td><td>Adult Women n (%)</td><td>p-Value *</td></tr><tr><td>Late antenatal visit</td><td>42,855</td><td>614 (30.7)</td><td>5148 (12.6)</td><td><0.001</td></tr><tr><td>BMI, kg/m2</td><td>42,751</td><td></td><td></td><td><0.001</td></tr><tr><td><18.5</td><td></td><td>219 (11.0)</td><td>2604 (6.4)</td><td></td></tr><tr><td>18.5β24.9</td><td></td><td>1465 (73.3)</td><td>25,985 (63.8)</td><td></td></tr><tr><td>β₯25</td><td></td><td>314 (15.7)</td><td>12,164 (29.8)</td><td></td></tr><tr><td>Smoking</td><td>39,888</td><td>604 (31.6)</td><td>5875 (15.5)</td><td><0.001</td></tr><tr><td>Evidence of alcohol abuse</td><td>43,318</td><td>7 (0.3)</td><td>171 (0.4)</td><td>0.631</td></tr><tr><td>Evidence of drug abuse</td><td>43,320</td><td>0 (0.0)</td><td>14 (0.0)</td><td>0.406</td></tr></table>
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<table><tr><td>Folic acid intake</td><td>43,191</td><td>866 (42.9)</td><td>22,117 (53.7)</td><td><0.001</td></tr><tr><td>Multivitamin intake</td><td>43,192</td><td>961 (47.6)</td><td>22,332 (54.2)</td><td><0.001</td></tr><tr><td>Infections of kidney in pregnancy 1</td><td>43,327</td><td>762 (37.5)</td><td>13,980 (33.9)</td><td>0.001</td></tr><tr><td>Infections of the genital tract in pregnancy 2</td><td>43,327</td><td>495 (24.3)</td><td>6600 (16.0)</td><td><0.001</td></tr><tr><td>Parity (para)</td><td>39,249</td><td>160 (8.9)</td><td>21,553 (57.6)</td><td><0.001</td></tr></table>
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e8cd4bc773850339c158d62191422823380150d6eb96030e1b38c0b6271e51ef.png
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complex
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<table><tr><td>Characteristics</td><td><i>n</i> (%)</td></tr><tr><td>Maternal age (years) </td></tr><tr><td><20</td><td>40 (9.1)</td></tr><tr><td>20–24</td><td>163 (36.9)</td></tr><tr><td>25–29</td><td>144 (32.6)</td></tr><tr><td>30–34</td><td>66 (14.9)</td></tr><tr><td>≥35</td><td>29 (6.6)</td></tr><tr><td>Parity</td></tr><tr><td>0</td><td>139 (31.5)</td></tr><tr><td>≥1</td><td>303 (68.6)</td></tr><tr><td>Race/ethnicity</td></tr><tr><td>Latina</td><td>426 (96.4)</td></tr><tr><td>Non-Latina, white</td><td>7 (1.6)</td></tr><tr><td>Other</td><td>9 (2.0)</td></tr><tr><td>Marital status</td></tr><tr><td>Married or living as married</td><td>356 (80.5)</td></tr><tr><td>Unmarried</td><td>86 (19.5)</td></tr><tr><td>Maternal education</td></tr><tr><td>≤6th grade</td><td>188 (42.5)</td></tr><tr><td>Some high school</td><td>158 (35.8)</td></tr><tr><td>High school graduate</td><td>96 (21.7)</td></tr><tr><td>Family income</td></tr><tr><td>≤ Poverty</td><td>272 (61.5)</td></tr><tr><td>Poverty–200%</td><td>154 (34.8)</td></tr><tr><td>>200%</td><td>16 (3.6)</td></tr><tr><td>Country of birth</td></tr><tr><td>United States</td><td>59 (13.4)</td></tr><tr><td>Mexico</td><td>374 (84.6)</td></tr><tr><td>Other</td><td>9 (2.0)</td></tr><tr><td>Years of residence in the United States</td></tr><tr><td>≤5 years</td><td>230 (52.0)</td></tr><tr><td>6–10 years</td><td>99 (22.4)</td></tr><tr><td>≥11 years</td><td>63 (14.3)</td></tr><tr><td>Entire life</td><td>50 (11.3)</td></tr><tr><td>Work status during pregnancy</td></tr><tr><td>Did not work</td><td>172 (38.9)</td></tr><tr><td>Some field or agricultural work</td><td>181 (41.0)</td></tr><tr><td>Other work</td><td>89 (20.1)</td></tr><tr><td>Prepregnancy body mass index (kg/m<sup>2</sup>)</td></tr><tr><td>Underweight (<18.5)</td><td>2 (0.5)</td></tr><tr><td>Normal (18.5–24.9)</td><td>170 (38.5)</td></tr><tr><td>Overweight (25–29.9)</td><td>175 (39.6)</td></tr><tr><td>Obese (>30)</td><td>95 (21.5)</td></tr><tr><td>Smoked during pregnancy</td></tr><tr><td>Yes</td><td>26 (5.9)</td></tr><tr><td>No</td><td>416 (94.1)</td></tr><tr><td>Any moves during pregnancy</td></tr><tr><td>Yes</td><td>182 (41.2)</td></tr><tr><td>No</td><td>260 (58.8)</td></tr><tr><td>Low birth weight<sup><i>a</i></sup> infant</td></tr><tr><td>Yes</td><td>17 (3.9)</td></tr><tr><td>No</td><td>425 (96.2)</td></tr><tr><td>Preterm<sup><i>b</i></sup> infant</td></tr><tr><td>Yes</td><td>30 (6.8)</td></tr><tr><td>No</td><td>412 (93.2)</td></tr><tr><td colspan="2"><sup><i>a</i></sup>Low birth weight is defined as <2,500g.<sup><i>b</i></sup>Preterm birth is defined as <37 weeks gestation.</td></tr></table>
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<table><tr><td>Characteristics</td><td>n (%)</td></tr><tr><td>Maternal age (years)</td><td></td></tr></table>
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<table><tr><td><20</td><td>40 (9.1)</td></tr><tr><td>20β24</td><td>163 (36.9)</td></tr><tr><td>25β29</td><td>144 (32.6)</td></tr><tr><td>30β34</td><td>66 (14.9)</td></tr><tr><td>β₯35</td><td>29 (6.6)</td></tr><tr><td>Parity</td><td></td></tr><tr><td>0</td><td>139 (31.5)</td></tr><tr><td>β₯1</td><td>303 (68.6)</td></tr><tr><td>Race/ethnicity</td><td></td></tr><tr><td>Latina</td><td>426 (96.4)</td></tr><tr><td>Non-Latina, white</td><td>7 (1.6)</td></tr><tr><td>Other</td><td>9 (2.0)</td></tr><tr><td>Marital status</td><td></td></tr><tr><td>Married or living as married</td><td>356 (80.5)</td></tr><tr><td>Unmarried</td><td>86 (19.5)</td></tr><tr><td>Maternal education</td><td></td></tr><tr><td>β€6th grade</td><td>188 (42.5)</td></tr><tr><td>Some high school</td><td>158 (35.8)</td></tr><tr><td>High school graduate</td><td>96 (21.7)</td></tr><tr><td>Family income</td><td></td></tr><tr><td>β€ Poverty</td><td>272 (61.5)</td></tr><tr><td>Povertyβ200%</td><td>154 (34.8)</td></tr><tr><td>>200%</td><td>16 (3.6)</td></tr><tr><td>Country of birth</td><td></td></tr><tr><td>United States</td><td>59 (13.4)</td></tr><tr><td>Mexico</td><td>374 (84.6)</td></tr><tr><td>Other</td><td>9 (2.0)</td></tr><tr><td>Years of residence in the United States</td><td></td></tr><tr><td>β€5 years</td><td>230 (52.0)</td></tr><tr><td>6β10 years</td><td>99 (22.4)</td></tr><tr><td>β₯11 years</td><td>63 (14.3)</td></tr><tr><td>Entire life</td><td>50 (11.3)</td></tr><tr><td>Work status during pregnancy</td><td></td></tr><tr><td>Did not work</td><td>172 (38.9)</td></tr><tr><td>Some field or agricultural work</td><td>181 (41.0)</td></tr><tr><td>Other work</td><td>89 (20.1)</td></tr><tr><td>Prepregnancy body mass index (kg/m2)</td><td></td></tr><tr><td>Underweight (<18.5)</td><td>2 (0.5)</td></tr><tr><td>Normal (18.5β24.9)</td><td>170 (38.5)</td></tr><tr><td>Overweight (25β29.9)</td><td>175 (39.6)</td></tr><tr><td>Obese (>30)</td><td>95 (21.5)</td></tr><tr><td>Smoked during pregnancy</td><td></td></tr><tr><td>Yes</td><td>26 (5.9)</td></tr><tr><td>No</td><td>416 (94.1)</td></tr><tr><td>Any moves during pregnancy</td><td></td></tr><tr><td>Yes</td><td>182 (41.2)</td></tr><tr><td>No</td><td>260 (58.8)</td></tr><tr><td>Low birth weighta infant</td><td></td></tr><tr><td>Yes</td><td>17 (3.9)</td></tr><tr><td>No</td><td>425 (96.2)</td></tr><tr><td>Pretermb infant</td><td></td></tr><tr><td>Yes</td><td>30 (6.8)</td></tr><tr><td>No</td><td>412 (93.2)</td></tr><tr><td colspan="2">aLow birth weight is defined as <2,500g.bPreterm birth is defined as <37 weeks gestation.</td></tr></table>
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1849e8499ae7489bfd59b19718d21be2a5c6228fc7758bf246553c3c88c1b57c.png
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complex
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<table><tr><td colspan="2">Intake scenarios</td><td colspan="5">Exposure for different ethyl carbamate concentration scenarios in spirits [ng/kg bw/day]</td></tr><tr><td>Drinks per day</td><td>Volume of spirit consumed [mL]</td><td>Mean</td><td>Median</td><td>90th percentile</td><td>95th percentile</td><td>99th percentile</td></tr><tr><td>1</td><td>25</td><td>21</td><td>17</td><td>42</td><td>58</td><td>92</td></tr><tr><td>2</td><td>50</td><td>42</td><td>33</td><td>83</td><td>117</td><td>183</td></tr><tr><td>3</td><td>75</td><td>63</td><td>50</td><td>125</td><td>175</td><td>275</td></tr><tr><td>4</td><td>100</td><td>83</td><td>67</td><td>167</td><td>233</td><td>367</td></tr><tr><td>5</td><td>125</td><td>104</td><td>83</td><td>208</td><td>292</td><td>458</td></tr></table>
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<table><tr><td colspan="2">Intake scenarios</td><td colspan="5">Exposure for different ethyl carbamate concentration scenarios in spirits [ng/kg bw/day]</td></tr><tr><td>Drinks per day</td><td>Volume of spirit consumed [mL]</td><td>Mean</td><td>Median</td><td>90th percentile</td><td>95th percentile</td><td>99th percentile</td></tr><tr><td>1</td><td>25</td><td>21</td><td>17</td><td>42</td><td>58</td><td>92</td></tr><tr><td>2</td><td>50</td><td>42</td><td>33</td><td>83</td><td>117</td><td>183</td></tr><tr><td>3</td><td>75</td><td>63</td><td>50</td><td>125</td><td>175</td><td>275</td></tr><tr><td></td><td>10</td><td>83</td><td>6</td><td>167</td><td>23</td><td>367</td></tr></table>
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<table><tr><td>4</td><td>0</td><td></td><td>7</td><td></td><td>3</td><td></td></tr><tr><td>5</td><td>125</td><td>104</td><td>83</td><td>208</td><td>292</td><td>458</td></tr></table>
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fff127fbe8e9d30b2888e45fcf0928f67d2f7f9a23ebdede492fa2e98fac9603.png
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complex
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<table><tr><td rowspan="2"></td><td colspan="2">ELISA titer anti-STn</td><td>ELISA titer anti-modified-STn</td></tr><tr><td>IgG</td><td>IgM</td><td>IgG</td></tr><tr><td>KLH</td><td>< 100</td><td>< 100</td><td>------</td></tr><tr><td>1-KLH</td><td>15309</td><td>< 100</td><td>15309</td></tr><tr><td>2-KLH</td><td>293812</td><td>< 100</td><td>588662</td></tr><tr><td>3-KLH</td><td>7384</td><td>< 100</td><td>14794</td></tr><tr><td>4-KLH</td><td>555186</td><td>< 100</td><td>1061530</td></tr></table>
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<table><tr><td rowspan="2"></td><td>ELISA titer anti-STn</td></tr><tr><td>IgG</td></tr><tr><td>KLH</td><td>< 100</td></tr><tr><td>1-KLH</td><td>15309</td></tr><tr><td>2-KLH</td><td>293812</td></tr><tr><td>3-KLH</td><td>7384</td></tr><tr><td>4-KLH</td><td>555186</td></tr></table>
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<table><tr><td>ELISA titer anti-STn</td><td>ELISA titer anti-modified-STn</td></tr><tr><td>IgM</td><td>IgG</td></tr><tr><td>< 100</td><td>------</td></tr><tr><td>< 100</td><td>15309</td></tr><tr><td>< 100</td><td>588662</td></tr><tr><td>< 100</td><td>14794</td></tr><tr><td>< 100</td><td>1061530</td></tr></table>
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5a9c0511b4a8bf030065bfb824ce89c2767088426c2e3d0852b3da1f43dfbc46.png
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simple
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<table><tr><td>Complication</td><td>Total vivax</td><td>Total patients with severity sign</td><td>Pooled prevalence, %</td><td>95% CI, %</td></tr><tr><td>Death</td><td>46411</td><td>353</td><td>0.3</td><td>0.1–0.4</td></tr><tr><td>Cerebral malaria</td><td>45845</td><td>532</td><td>0.8</td><td>0.5–1.1</td></tr><tr><td>Multiple convulsions</td><td>46386</td><td>88</td><td>0.2</td><td>0–0.5</td></tr><tr><td>Renal dysfunction</td><td>46341</td><td>244</td><td>1.1</td><td>0.3–1.9</td></tr><tr><td>Respiratory dysfunction</td><td>46411</td><td>144</td><td>0.3</td><td>0.1–0.5</td></tr><tr><td>Hepatic dysfunction</td><td>46536</td><td>727</td><td>4.2</td><td>3.2–5.2</td></tr><tr><td>Abnormal bleeding/DIC</td><td>46346</td><td>206</td><td>0.6</td><td>0.2–1</td></tr><tr><td>Haemoglobinuria</td><td>46411</td><td>93</td><td>0.1</td><td>0–0.4</td></tr><tr><td>Hypoglycaemia</td><td>46381</td><td>44</td><td>1.8</td><td>0.9–2.7</td></tr><tr><td>Metabolic acidosis</td><td>46341</td><td>138</td><td>1</td><td>0–2.3</td></tr><tr><td>Circulatory collapse/Shock</td><td>46411</td><td>67</td><td>5.1</td><td>2.5–7.7</td></tr><tr><td>Severe anaemia</td><td>46411</td><td>2276</td><td>4</td><td>2.9–5.1</td></tr><tr><td>Severe thrombocytopenia</td><td>45775</td><td>888</td><td>8.6</td><td>5.4–11.8</td></tr></table>
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<table><tr><td>Complication</td><td>Total vivax</td><td>Total patients with severity sign</td><td>Pooled prevalence, %</td><td>95% CI, %</td></tr><tr><td>Death</td><td>46411</td><td>353</td><td>0.3</td><td>0.1β0.4</td></tr><tr><td>Cerebral malaria</td><td>45845</td><td>532</td><td>0.8</td><td>0.5β1.1</td></tr><tr><td>Multiple convulsions</td><td>46386</td><td>88</td><td>0.2</td><td>0β0.5</td></tr><tr><td>Renal dysfunction</td><td>46341</td><td>244</td><td>1.1</td><td>0.3β1.9</td></tr><tr><td>Respiratory dysfunction</td><td>46411</td><td>144</td><td>0.3</td><td>0.1β0.5</td></tr><tr><td>Hepatic dysfunction</td><td>46536</td><td>727</td><td>4.2</td><td>3.2β5.2</td></tr><tr><td>Abnormal bleeding/DIC</td><td>46346</td><td>206</td><td>0.6</td><td>0.2β1</td></tr><tr><td>Haemoglobinuria</td><td>46411</td><td>93</td><td>0.1</td><td>0β0.4</td></tr><tr><td>Hypoglycaemia</td><td>46381</td><td>44</td><td>1.8</td><td>0.9β2.7</td></tr><tr><td>Metabolic acidosis</td><td>46341</td><td>138</td><td>1</td><td>0β2.3</td></tr></table>
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<table><tr><td>Circulatory collapse/Shock</td><td>46411</td><td>67</td><td>5.1</td><td>2.5β7.7</td></tr><tr><td>Severe anaemia</td><td>46411</td><td>2276</td><td>4</td><td>2.9β5.1</td></tr><tr><td>Severe thrombocytopenia</td><td>45775</td><td>888</td><td>8.6</td><td>5.4β11.8</td></tr></table>
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c0815c039c9f660efd8e2c6c8ad5a509e3dbc6287e6a5a8fa2a126cf738b05c5.png
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simple
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<table><tr><td>Phase</td><td>Start-up</td><td>Adaptation</td><td>HRT 24</td><td>HRT 18</td><td>HRT 12</td></tr><tr><td>Days (d)</td><td>1–58 d (58 d)</td><td>59–151 d (93 d)</td><td>152–185 d (34 d)</td><td>186–240 d (55 d)</td><td>241–297 d (57)</td></tr><tr><td>Benzothiazole (mg/L)</td><td>0</td><td>1–50</td><td>50</td><td>50</td><td>50</td></tr><tr><td>HRT (h)</td><td>24</td><td>24</td><td>24</td><td>18</td><td>12</td></tr><tr><td>Temperature (°C)</td><td>35</td><td>35</td><td>35</td><td>35</td><td>35</td></tr><tr><td>OLR (kg COD/m<sup>3</sup>·d)</td><td>3.33</td><td>3.26</td><td>3.13</td><td>4.64</td><td>6.36</td></tr></table>
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<table><tr><td>Phase</td><td>Start-up</td><td>Adaptation</td><td>HRT 24</td><td>HRT 18</td><td>HRT 12</td></tr><tr><td>Days (d)</td><td>1β58 d (58 d)</td><td>59β151 d (93 d)</td><td>152β185 d (34 d)</td><td>186β240 d (55 d)</td><td>241β297 d (57)</td></tr><tr><td>Benzothiazole (mg/L)</td><td>0</td><td>1β50</td><td>50</td><td>50</td><td>50</td></tr></table>
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<table><tr><td>HRT (h)</td><td>24</td><td>24</td><td>24</td><td>18</td><td>12</td></tr><tr><td>Temperature (Β°C)</td><td>35</td><td>35</td><td>35</td><td>35</td><td>35</td></tr><tr><td>OLR (kg COD/m3Β·d)</td><td>3.33</td><td>3.26</td><td>3.13</td><td>4.64</td><td>6.36</td></tr></table>
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16589b27e34b1710df15f988de060854c0717aed3c1c05af12916a413a98c18a.png
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complex
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<table><tr><td> </td><td colspan="5"><i>K</i><sub>A</sub> (μM)<sup>a</sup></td></tr><tr><td>Comp.H</td><td>hCA I</td><td>hCA II</td><td>hCA IV</td><td>hCA VII</td><td>hCA IX</td></tr><tr><td>1</td><td>18.4</td><td>54.2</td><td>47.1</td><td>20.6</td><td>31.4</td></tr><tr><td>2</td><td>1.60</td><td>21.7</td><td>0.0018</td><td>21.9</td><td>7.81</td></tr><tr><td>3</td><td>0.85</td><td>36.8</td><td>1.24</td><td>0.81</td><td>15.8</td></tr><tr><td>4</td><td>0.24</td><td>37.9</td><td>1.03</td><td>0.052</td><td>39.9</td></tr><tr><td>5</td><td>1.17</td><td>34.2</td><td>2.15</td><td>0.061</td><td>26.4</td></tr><tr><td>6</td><td>1.02</td><td>25.8</td><td>1.70</td><td>0.012</td><td>41.7</td></tr><tr><td>7</td><td>0.94</td><td>14.5</td><td>1.86</td><td>0.038</td><td>20.5</td></tr><tr><td>8</td><td>0.80</td><td>8.62</td><td>0.93</td><td>0.006</td><td>31.8</td></tr><tr><td>9</td><td>2.83</td><td>9.27</td><td>0.96</td><td>0.012</td><td>30.0</td></tr><tr><td>10</td><td>4.14</td><td>10.4</td><td>1.51</td><td>0.007</td><td>62.6</td></tr><tr><td>11</td><td>10.7</td><td>21.9</td><td>36.8</td><td>12.6</td><td>65.4</td></tr><tr><td>12</td><td>8.52</td><td>11.2</td><td>18.9</td><td>24.6</td><td>47.9</td></tr><tr><td>13</td><td>11.2</td><td>24.3</td><td>25.7</td><td>7.13</td><td>48.1</td></tr><tr><td>14</td><td>12.7</td><td>21.2</td><td>33.5</td><td>11.4</td><td>51.2</td></tr><tr><td>15</td><td>20.4</td><td>45.2</td><td>29.1</td><td>8.23</td><td>49.0</td></tr><tr><td>16</td><td>24.3</td><td>30.7</td><td>20.0</td><td>7.16</td><td>47.9</td></tr><tr><td>17</td><td>14.1</td><td>58.9</td><td>24.1</td><td>6.26</td><td>31.6</td></tr><tr><td>18</td><td>9.64</td><td>63.4</td><td>28.3</td><td>9.51</td><td>47.9</td></tr><tr><td>19</td><td>17.8</td><td>44.5</td><td>29.0</td><td>8.44</td><td>58.2</td></tr><tr><td>20</td><td>10.4</td><td>41.8</td><td>30.5</td><td>0.78</td><td>57.6</td></tr><tr><td>HST</td><td>2.10</td><td>125</td><td>4.03</td><td>37.6</td><td>35.2</td></tr></table>
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<table><tr><td></td><td colspan="5">KA (ΞΌM)a</td></tr><tr><td>Comp.H</td><td>hCA I</td><td>hCA II</td><td>hCA IV</td><td>hCA VII</td><td>hCA IX</td></tr><tr><td>1</td><td>18.4</td><td>54.2</td><td>47.1</td><td>20.6</td><td>31.4</td></tr><tr><td>2</td><td>1.60</td><td>21.7</td><td>0.0018</td><td>21.9</td><td>7.81</td></tr><tr><td>3</td><td>0.</td><td>3</td><td>1.</td><td>0</td><td>1</td></tr></table>
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<table><tr><td></td><td colspan="5">KA (ΞΌM)a</td></tr><tr><td>Comp.H</td><td>hCA I</td><td>hCA II</td><td>hCA IV</td><td>hCA VII</td><td>hCA IX</td></tr><tr><td></td><td>85</td><td>6.8</td><td>24</td><td>.81</td><td>5.8</td></tr><tr><td>4</td><td>0.24</td><td>37.9</td><td>1.03</td><td>0.052</td><td>39.9</td></tr><tr><td>5</td><td>1.17</td><td>34.2</td><td>2.15</td><td>0.061</td><td>26.4</td></tr><tr><td>6</td><td>1.02</td><td>25.8</td><td>1.70</td><td>0.012</td><td>41.7</td></tr><tr><td>7</td><td>0.94</td><td>14.5</td><td>1.86</td><td>0.038</td><td>20.5</td></tr><tr><td>8</td><td>0.80</td><td>8.62</td><td>0.93</td><td>0.006</td><td>31.8</td></tr><tr><td>9</td><td>2.83</td><td>9.27</td><td>0.96</td><td>0.012</td><td>30.0</td></tr><tr><td>10</td><td>4.14</td><td>10.4</td><td>1.51</td><td>0.007</td><td>62.6</td></tr><tr><td>11</td><td>10.7</td><td>21.9</td><td>36.8</td><td>12.6</td><td>65.4</td></tr><tr><td>12</td><td>8.52</td><td>11.2</td><td>18.9</td><td>24.6</td><td>47.9</td></tr><tr><td>13</td><td>11.2</td><td>24.3</td><td>25.7</td><td>7.13</td><td>48.1</td></tr><tr><td>14</td><td>12.7</td><td>21.2</td><td>33.5</td><td>11.4</td><td>51.2</td></tr><tr><td>15</td><td>20.4</td><td>45.2</td><td>29.1</td><td>8.23</td><td>49.0</td></tr><tr><td>16</td><td>24.3</td><td>30.7</td><td>20.0</td><td>7.16</td><td>47.9</td></tr><tr><td>17</td><td>14.1</td><td>58.9</td><td>24.1</td><td>6.26</td><td>31.6</td></tr><tr><td>18</td><td>9.64</td><td>63.4</td><td>28.3</td><td>9.51</td><td>47.9</td></tr><tr><td>19</td><td>17.8</td><td>44.5</td><td>29.0</td><td>8.44</td><td>58.2</td></tr><tr><td>20</td><td>10.4</td><td>41.8</td><td>30.5</td><td>0.78</td><td>57.6</td></tr><tr><td>HST</td><td>2.10</td><td>125</td><td>4.03</td><td>37.6</td><td>35.2</td></tr></table>
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6b70079b6001d8b301542cf047572b7c53ca445856d2ef79221634f267a4e60f.png
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complex
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<table><tr><td> </td><td>Recovered (N = 20)</td><td>Non-recovered (N = 21)</td><td>p-value</td></tr><tr><td>Age (years)</td><td>62.0 (51.8 - 79.8)</td><td>67 (56.4 - 75.5)</td><td>0.860</td></tr><tr><td>Creatinine at admission (mg/dL)</td><td>1.0 (0.8 - 1.4)</td><td>1.0 (0.8 - 1.4)</td><td>0.860</td></tr><tr><td>Glomerular filtration rate, MDRD (mL/min)</td><td>69.5 (46.0 - 99.5)</td><td>72.0 (42.5 - 89.5)</td><td>0.835</td></tr><tr><td>T0 urea (mg/dL)</td><td>134 (78.5 - 146.0)</td><td>140 (90 - 166)</td><td>0.630</td></tr><tr><td>T0 creatinine (mg/dL)</td><td>2.8 (2.2 - 5.0)</td><td>2.1 (1.8 - 3.4)</td><td>0.650</td></tr><tr><td>T0 Systolic blood pressure (mmHg)</td><td>93 (91.5 - 103.2)</td><td>97 (89 - 100)</td><td>0.630</td></tr><tr><td>T0 Diastolic blood pressure (mmHg)</td><td>48.5 (42 - 54.2)</td><td>45 (42 - 50.0)</td><td>0.162</td></tr><tr><td>T0 Central venous pressure (mmHg)</td><td>12.5 (10.2 - 14.0)</td><td>12 (9.0 - 14.5)</td><td>0.885</td></tr><tr><td>T0 albumin (g/L)</td><td>24.5 (20.0 - 27.0)</td><td>24 (18.5 - 25.5)</td><td>0.278</td></tr><tr><td>T0 lactate (mmol/L)</td><td>2.5 (1.6 - 5.6)</td><td>3.5 (1.7 - 4.8)</td><td>0.873</td></tr><tr><td>T0 Hb (g/dL)</td><td>11.3 (10.2 - 12.4)</td><td>10.2 (8.6 - 12.0)</td><td>0.440</td></tr><tr><td>T0 pH</td><td>7.32 (7.18 - 7.38)</td><td>7.29 (7.24 - 7.38)</td><td>0.642</td></tr><tr><td colspan="4">RIFLE</td></tr><tr><td>R</td><td>3 (15.0)</td><td>2 (9.5)</td><td>0.406</td></tr><tr><td>I</td><td>9 (45.0)</td><td>8 (38.1)</td><td> </td></tr><tr><td>F</td><td>8 (40.0)</td><td>11 (52.4)</td><td> </td></tr><tr><td>T0 PaO<sub>2</sub>/FiO<sub>2</sub> ratio</td><td>210 (160 - 280)</td><td>200 (95 - 225)</td><td>0.425</td></tr><tr><td>Pre-ICU days</td><td>0 (0 - 1.5)</td><td>2 (0.0 - 9.5)</td><td>0.140</td></tr><tr><td>ICU stay days</td><td>15 (8 - 25)</td><td>5 (2.5 - 12.5)</td><td>0.086</td></tr><tr><td>Cumulative fluid balance (mL)</td><td>3850 (1425 - 8025)</td><td>11500 (6625 - 16275)</td><td>0.004</td></tr><tr><td>ICU/initiation of renal replacement therapy</td><td>1.0 (0.0 - 2.0)</td><td>1.0 (0.0 - 1.5)</td><td>0.925</td></tr><tr><td>Hospital admission/initiation of renal replacement therapy</td><td>1.0 (0.0 - 4.0)</td><td>4.0 (1.0 - 15.0)</td><td>0.158</td></tr><tr><td>SAPS II</td><td>51 (45.8 - 56.2)</td><td>73 (54 - 84)</td><td>0.005</td></tr><tr><td>Congestive heart failure</td><td>4</td><td>5</td><td>0.77</td></tr><tr><td>Cirrhosis</td><td>0</td><td>5</td><td>0.020</td></tr></table>
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<table><tr><td></td><td>Recovered (N = 20)</td><td>Non-recovered (N = 21)</td><td>p-value</td></tr><tr><td>Age (ye</td><td>62.0 </td><td>67 (</td><td>0.860</td></tr></table>
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<table><tr><td>ars)</td><td>(51.8 - 79.8)</td><td>56.4 - 75.5)</td><td></td></tr><tr><td>Creatinine at admission (mg/dL)</td><td>1.0 (0.8 - 1.4)</td><td>1.0 (0.8 - 1.4)</td><td>0.860</td></tr><tr><td>Glomerular filtration rate, MDRD (mL/min)</td><td>69.5 (46.0 - 99.5)</td><td>72.0 (42.5 - 89.5)</td><td>0.835</td></tr><tr><td>T0 urea (mg/dL)</td><td>134 (78.5 - 146.0)</td><td>140 (90 - 166)</td><td>0.630</td></tr><tr><td>T0 creatinine (mg/dL)</td><td>2.8 (2.2 - 5.0)</td><td>2.1 (1.8 - 3.4)</td><td>0.650</td></tr><tr><td>T0 Systolic blood pressure (mmHg)</td><td>93 (91.5 - 103.2)</td><td>97 (89 - 100)</td><td>0.630</td></tr><tr><td>T0 Diastolic blood pressure (mmHg)</td><td>48.5 (42 - 54.2)</td><td>45 (42 - 50.0)</td><td>0.162</td></tr><tr><td>T0 Central venous pressure (mmHg)</td><td>12.5 (10.2 - 14.0)</td><td>12 (9.0 - 14.5)</td><td>0.885</td></tr><tr><td>T0 albumin (g/L)</td><td>24.5 (20.0 - 27.0)</td><td>24 (18.5 - 25.5)</td><td>0.278</td></tr><tr><td>T0 lactate (mmol/L)</td><td>2.5 (1.6 - 5.6)</td><td>3.5 (1.7 - 4.8)</td><td>0.873</td></tr><tr><td>T0 Hb (g/dL)</td><td>11.3 (10.2 - 12.4)</td><td>10.2 (8.6 - 12.0)</td><td>0.440</td></tr><tr><td>T0 pH</td><td>7.32 (7.18 - 7.38)</td><td>7.29 (7.24 - 7.38)</td><td>0.642</td></tr><tr><td colspan="4">RIFLE</td></tr><tr><td>R</td><td>3 (15.0)</td><td>2 (9.5)</td><td>0.406</td></tr><tr><td>I</td><td>9 (45.0)</td><td>8 (38.1)</td><td></td></tr><tr><td>F</td><td>8 (40.0)</td><td>11 (52.4)</td><td></td></tr><tr><td>T0 PaO2/FiO2 ratio</td><td>210 (160 - 280)</td><td>200 (95 - 225)</td><td>0.425</td></tr><tr><td>Pre-ICU days</td><td>0 (0 - 1.5)</td><td>2 (0.0 - 9.5)</td><td>0.140</td></tr><tr><td>ICU stay days</td><td>15 (8 - 25)</td><td>5 (2.5 - 12.5)</td><td>0.086</td></tr><tr><td>Cumulative fluid balance (mL)</td><td>3850 (1425 - 8025)</td><td>11500 (6625 - 16275)</td><td>0.004</td></tr><tr><td>ICU/initiation of renal replacement therapy</td><td>1.0 (0.0 - 2.0)</td><td>1.0 (0.0 - 1.5)</td><td>0.925</td></tr><tr><td>Hospital admission/initiation of renal replacement therapy</td><td>1.0 (0.0 - 4.0)</td><td>4.0 (1.0 - 15.0)</td><td>0.158</td></tr><tr><td>SAPS II</td><td>51 (45.8 - 56.2)</td><td>73 (54 - 84)</td><td>0.005</td></tr><tr><td>Congestive heart failure</td><td>4</td><td>5</td><td>0.77</td></tr><tr><td>Cirrhosis</td><td>0</td><td>5</td><td>0.020</td></tr></table>
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5e90d685572ee5d37754105dbfc5f9407a94d61cebb642817817a61127b6e80e.png
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complex
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<table><tr><td rowspan="2">Approach</td><td colspan="3">Accuracy (%)</td></tr><tr><td>Precision</td><td>Recall</td><td>F1 Score</td></tr><tr><td>Hierarchical MEMM [39]</td><td>67.9</td><td>55.5</td><td>61.08</td></tr><tr><td>3D SMoSIFT [1]</td><td>74.8</td><td>65.8</td><td>70.01</td></tr><tr><td>Ni et al., 2013 [46]</td><td>75.9</td><td>69.5</td><td>72.56</td></tr><tr><td>Guptal et al., 2013 [47]</td><td>78.1</td><td>75.4</td><td>76.73</td></tr><tr><td>Zhang and Tian 2012 [48]</td><td>86.0</td><td>84.0</td><td>84.99</td></tr><tr><td>MFSK 2016 [9]</td><td>87.1</td><td>83.8</td><td>85.42</td></tr><tr><td>Zhu et al., 2014 [43]</td><td>93.2</td><td>84.6</td><td>88.69</td></tr><tr><td>Parisi et al., 2015 [44]</td><td>91.9</td><td>90.2</td><td>91.47</td></tr><tr><td>DBMM [45]</td><td>91.1</td><td>91.9</td><td>91.50</td></tr><tr><td>Proposed feature (ALSTF)</td><td>89.7</td><td>86.1</td><td>87.86</td></tr></table>
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<table><tr><td rowspan="2">Approach</td><td colspan="3">Accuracy (%)</td></tr><tr><td>Precision</td><td>Recall</td><td>F1 Score</td></tr><tr><td>Hierarchical MEMM [39]</td><td>67.9</td><td>55.5</td><td>61.08</td></tr><tr><td>3D SMoSIFT [1]</td><td>74.8</td><td>65.8</td><td>70.01</td></tr><tr><td>Ni et al., 2013 [46]</td><td>75.9</td><td>69.5</td><td>72.56</td></tr><tr><td>Guptal et al., 2013 [47]</td><td>78.1</td><td>75.4</td><td>76.73</td></tr><tr><td>Zhang and Tian 2012 [48]</td><td>86.0</td><td>84.0</td><td>84.99</td></tr><tr><td>MFSK 2016 [9]</td><td>87.1</td><td>83.8</td><td>85.42</td></tr><tr><td>Zhu et al., 2014 </td><td>93</td><td>84.6</td><td>88.6</td></tr></table>
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<table><tr><td>[43]</td><td>.2</td><td></td><td>9</td></tr><tr><td>Parisi et al., 2015 [44]</td><td>91.9</td><td>90.2</td><td>91.47</td></tr><tr><td>DBMM [45]</td><td>91.1</td><td>91.9</td><td>91.50</td></tr><tr><td>Proposed feature (ALSTF)</td><td>89.7</td><td>86.1</td><td>87.86</td></tr></table>
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2b43c689f54d73d6c97b55e63bfeee5b480a069140df4324d268c3d2be3a1cfe.png
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simple
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<table><tr><td>Methods</td><td>Our algorithm</td><td>Traditional method</td></tr><tr><td>Computation time (s)</td><td>163</td><td>217</td></tr><tr><td>MSE</td><td>4.39 × 10<sup>-4</sup></td><td>4.79 × 10<sup>-4</sup></td></tr></table>
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<table><tr><td>Methods</td><td>Our algorithm</td><td>Traditional method</td></tr><tr><td>Computation time (s)</td><td>163</td><td>217</td></tr></table>
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<table><tr><td>MSE</td><td>4.39 Γ 10-4</td><td>4.79 Γ 10-4</td></tr></table>
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13f7d122d9c42939e168f9544a9741cdf735654a7aaea5d38b0bcc303470fa1c.png
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simple
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<table><tr><td></td><td>Three weeks before treatment</td><td>Penultimate treatment day</td><td>Last treatment day</td><td>Reference data (n = 74 *)</td></tr><tr><td>Treated</td><td>2.72</td><td>2.67</td><td>2.99</td><td>2.43 ± 0.56 </td></tr><tr><td>Control</td><td>3.09</td><td>2.09</td><td>2.69</td><td>2.43 ± 0.56</td></tr></table>
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<table><tr><td></td><td>Three weeks before treatment</td><td>Penultimate treatment day</td><td>Last treatment day</td><td>Reference data (n = 74 *)</td></tr></table>
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<table><tr><td>Treated</td><td>2.72</td><td>2.67</td><td>2.99</td><td>2.43 Β± 0.56</td></tr><tr><td>Control</td><td>3.09</td><td>2.09</td><td>2.69</td><td>2.43 Β± 0.56</td></tr></table>
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96c8768f9aa828cd3dce307c28a3ec8f8b1cf85663b2bc9dedb417bf6cb1b662.png
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simple
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<table><tr><td>FP</td><td>Metrics</td><td>BCF R<sup>2</sup></td><td>BCF RMSE</td><td>LogP R<sup>2</sup></td><td>LogP RMSE</td><td>DES</td><td>UTI</td></tr><tr><td>Extended</td><td>37</td><td>0.546</td><td>0.917</td><td>0.775</td><td>0.872</td><td>0.970</td><td>0.971</td></tr><tr><td>Extended</td><td>34</td><td>0.546</td><td>0.919</td><td>0.776</td><td>0.870</td><td>0.970</td><td>0.970</td></tr><tr><td>Extended</td><td>18</td><td>0.542</td><td>0.922</td><td>0.777</td><td>0.869</td><td>0.965</td><td>0.965</td></tr><tr><td>Pubchem</td><td>28</td><td>0.541</td><td>0.906</td><td>0.772</td><td>0.870</td><td>0.963</td><td>0.963</td></tr><tr><td>Extended</td><td>42</td><td>0.534</td><td>0.919</td><td>0.780</td><td>0.858</td><td>0.961</td><td>0.962</td></tr><tr><td>Default</td><td>18</td><td>0.549</td><td>0.913</td><td>0.766</td><td>0.890</td><td>0.954</td><td>0.955</td></tr><tr><td>Extended</td><td>13</td><td>0.541</td><td>0.913</td><td>0.770</td><td>0.875</td><td>0.954</td><td>0.954</td></tr><tr><td>Default</td><td>34</td><td>0.549</td><td>0.913</td><td>0.765</td><td>0.891</td><td>0.953</td><td>0.953</td></tr><tr><td>Extended</td><td>1</td><td>0.540</td><td>0.917</td><td>0.770</td><td>0.876</td><td>0.950</td><td>0.950</td></tr><tr><td>Default</td><td>37</td><td>0.549</td><td>0.913</td><td>0.764</td><td>0.893</td><td>0.950</td><td>0.950</td></tr></table>
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<table><tr><td>FP</td><td>Metrics</td><td>BCF R2</td><td>BCF RMSE</td><td>LogP R2</td><td>LogP RMSE</td><td>DES</td><td>UTI</td></tr><tr><td>Extended</td><td>37</td><td>0.546</td><td>0.917</td><td>0.775</td><td>0.872</td><td>0.970</td><td>0.971</td></tr><tr><td>Extended</td><td>34</td><td>0.546</td><td>0.919</td><td>0.776</td><td>0.870</td><td>0.970</td><td>0.970</td></tr><tr><td>Extended</td><td>1</td><td>0.54</td><td>0.922</td><td>0.7</td><td>0.</td><td>0.9</td><td>0.</td></tr></table>
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<table><tr><td>FP</td><td>Metrics</td><td>BCF R2</td><td>BCF RMSE</td><td>LogP R2</td><td>LogP RMSE</td><td>DES</td><td>UTI</td></tr><tr><td></td><td>8</td><td>2</td><td></td><td>77</td><td>869</td><td>65</td><td>965</td></tr><tr><td>Pubchem</td><td>28</td><td>0.541</td><td>0.906</td><td>0.772</td><td>0.870</td><td>0.963</td><td>0.963</td></tr><tr><td>Extended</td><td>42</td><td>0.534</td><td>0.919</td><td>0.780</td><td>0.858</td><td>0.961</td><td>0.962</td></tr><tr><td>Default</td><td>18</td><td>0.549</td><td>0.913</td><td>0.766</td><td>0.890</td><td>0.954</td><td>0.955</td></tr><tr><td>Extended</td><td>13</td><td>0.541</td><td>0.913</td><td>0.770</td><td>0.875</td><td>0.954</td><td>0.954</td></tr><tr><td>Default</td><td>34</td><td>0.549</td><td>0.913</td><td>0.765</td><td>0.891</td><td>0.953</td><td>0.953</td></tr><tr><td>Extended</td><td>1</td><td>0.540</td><td>0.917</td><td>0.770</td><td>0.876</td><td>0.950</td><td>0.950</td></tr><tr><td>Default</td><td>37</td><td>0.549</td><td>0.913</td><td>0.764</td><td>0.893</td><td>0.950</td><td>0.950</td></tr></table>
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1b50ec1207b76d9f0835cdab0c43138d624a01309f9ab9ef8f7596b09a1f0bc6.png
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simple
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<table><tr><td>Diseases</td><td>BBB proteins and affected mechanisms</td></tr><tr><td>Alzheimer's disease</td><td>BBB disruption and permit peripheral IgG to brain. Decrease P-gp and accumulate amyloid-<i>β</i> in brain [67].</td></tr><tr><td>Parkinson's disease</td><td>BBB disruption increases therapeutic agent concentration and reduces efficacy of Pgp [6].</td></tr><tr><td>Stroke</td><td>Astrocytes secrete TGF<i>β</i> that downregulates tissue plasminogen activator (tPA) and anticoagulant thrombomodulin (TM) [68]. </td></tr><tr><td>Epilepsy</td><td>Transient BBB opening and upregulation of multiple drug resistance (MRD1) Pgp [69].</td></tr><tr><td>Trauma</td><td>Opening of BBB, release of IL-6 from astrocytes, and neuroinflammation [70].</td></tr><tr><td>HIV</td><td>BBB TJ disruption. Loss of glycoproteins and apoptosis of endothelial cell lead to increase diameter of cortical vessels [71]. </td></tr><tr><td>Infectious processes</td><td>Increase CSF/serum albumin ratio. Bacterial lipopolysaccharides affect BBB TJ [72].</td></tr><tr><td>Brain tumours</td><td>Breakdown of BBB TJ, overexpress folate, insulin, and transferrin receptor, and downregulation of claudin 1/3 [73].</td></tr><tr><td>Ischaemic brain oedema</td><td>BBB breakdown due to MMP9 release by neutrophils and degradation of occludin, claudins, and JAM [74].</td></tr></table>
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<table><tr><td>Diseases</td><td>BBB proteins and affected mechanisms</td></tr></table>
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<table><tr><td>Alzheimer's disease</td><td>BBB disruption and permit peripheral IgG to brain. Decrease P-gp and accumulate amyloid-Ξ² in brain [67].</td></tr><tr><td>Parkinson's disease</td><td>BBB disruption increases therapeutic agent concentration and reduces efficacy of Pgp [6].</td></tr><tr><td>Stroke</td><td>Astrocytes secrete TGFΞ² that downregulates tissue plasminogen activator (tPA) and anticoagulant thrombomodulin (TM) [68].</td></tr><tr><td>Epilepsy</td><td>Transient BBB opening and upregulation of multiple drug resistance (MRD1) Pgp [69].</td></tr><tr><td>Trauma</td><td>Opening of BBB, release of IL-6 from astrocytes, and neuroinflammation [70].</td></tr><tr><td>HIV</td><td>BBB TJ disruption. Loss of glycoproteins and apoptosis of endothelial cell lead to increase diameter of cortical vessels [71].</td></tr><tr><td>Infectious processes</td><td>Increase CSF/serum albumin ratio. Bacterial lipopolysaccharides affect BBB TJ [72].</td></tr><tr><td>Brain tumours</td><td>Breakdown of BBB TJ, overexpress folate, insulin, and transferrin receptor, and downregulation of claudin 1/3 [73].</td></tr><tr><td>Ischaemic brain oedema</td><td>BBB breakdown due to MMP9 release by neutrophils and degradation of occludin, claudins, and JAM [74].</td></tr></table>
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bf0a1fa52e90ecafdfa2e450683e7703c67955c6fdf4745bdaf3fb0091594a97.png
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complex
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<table><tr><td></td><td colspan="6">MOI</td></tr><tr><td></td><td>1</td><td>10</td><td>50</td><td>100</td><td>500</td><td>1000</td></tr><tr><td>Infection rates</td><td>0.47 ± 0.04</td><td>5.83 ± 0.07</td><td>10.65 ± 0.11</td><td>16.19 ± 0.31</td><td>20.27 ± 0.52</td><td>30.42 ± 2.31</td></tr><tr><td>Survivil rates</td><td>90.33 ± 1.21</td><td>85.27 ± 1.37</td><td>82.11 ± 1.63</td><td>81 ± 1.42</td><td>62.23 ± 2.15</td><td>40.25 ± 2.13</td></tr></table>
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<table><tr><td></td><td colspan="6">MOI</td></tr><tr><td></td><td>1</td><td>10</td><td>50</td><td>100</td><td>500</td><td>1000</td></tr></table>
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<table><tr><td>Infection rates</td><td>0.47 Β± 0.04</td><td>5.83 Β± 0.07</td><td>10.65 Β± 0.11</td><td>16.19 Β± 0.31</td><td>20.27 Β± 0.52</td><td>30.42 Β± 2.31</td></tr><tr><td>Survivil rates</td><td>90.33 Β± 1.21</td><td>85.27 Β± 1.37</td><td>82.11 Β± 1.63</td><td>81 Β± 1.42</td><td>62.23 Β± 2.15</td><td>40.25 Β± 2.13</td></tr></table>
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1c552b104123fef0671a82759342d9893fb265a94867ef72fd32dbec4793bf72.png
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simple
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<table><tr><td>Combinations</td><td>Sensitivity(%)</td><td>Specificity(%)</td><td>PPV(%)</td><td>NPV(%)</td></tr><tr><td>YKL-40</td><td>70.21</td><td>84.13</td><td>62.26</td><td>88.33</td></tr><tr><td>CEA</td><td>10.64</td><td>96.80</td><td>55.56</td><td>74.23</td></tr><tr><td>CYFRA21-1</td><td>40.43</td><td>92.06</td><td>65.52</td><td>80.56</td></tr><tr><td>YKL-40 or CEA</td><td>70.21</td><td>83.20</td><td>61.11</td><td>88.14</td></tr><tr><td>YKL-40 or CYFRA21-1</td><td>78.72</td><td>77.78</td><td>56.92</td><td>90.74</td></tr><tr><td>CEA or CYFRA21-1</td><td>46.80</td><td>89.60</td><td>62.86</td><td>81.75</td></tr><tr><td>YKL-40 or CEA or CYFRA21-1</td><td>78.72</td><td>76.80</td><td>56.06</td><td>90.57</td></tr></table>
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<table><tr><td>Combinations</td><td>Sensitivity(%)</td><td>Specificity(%)</td><td>PPV(%)</td></tr><tr><td>YKL-40</td><td>70.21</td><td>84.13</td><td>62.26</td></tr><tr><td>CEA</td><td>10.64</td><td>96.80</td><td>55.56</td></tr><tr><td>CYFRA21-1</td><td>40.43</td><td>92.06</td><td>65.52</td></tr><tr><td>YKL-40 or CEA</td><td>70.21</td><td>83.20</td><td>61.11</td></tr><tr><td>YKL-40 or CYFRA21-1</td><td>78.72</td><td>77.78</td><td>56.92</td></tr><tr><td>CEA or CYFRA21-1</td><td>46.80</td><td>89.60</td><td>62.86</td></tr><tr><td>YKL-40 or CEA or CYFRA21-1</td><td>78.72</td><td>76.80</td><td>56.06</td></tr></table>
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<table><tr><td>NPV(%)</td></tr><tr><td>88.33</td></tr><tr><td>74.23</td></tr><tr><td>80.56</td></tr><tr><td>88.14</td></tr><tr><td>90.74</td></tr><tr><td>81.75</td></tr><tr><td>90.57</td></tr></table>
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c356b3a7e0f37ef648a40cd87e0926b48d8935abf444f4882b5c2a848b8f616f.png
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simple
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<table><tr><td>Variables</td><td>Characteristics</td><td>All (N = 1179)</td><td>Females (N = 486)</td><td>Males (N = 693)</td><td>Chi-square</td></tr><tr><td> </td><td> </td><td>n (%)</td><td>n (%)</td><td>n (%)</td><td>(p-value)</td></tr><tr><td>Age</td><td>Younger (≤ 22 years)</td><td>608 (51.6)</td><td>215 (44.0)</td><td>393 (56.9)</td><td><.001</td></tr><tr><td> </td><td>Older (> 22 years)</td><td>571 (48.4)</td><td>271 (56.0)</td><td>300 (43.1)</td><td> </td></tr><tr><td>Role of religion while growing up</td><td>Major role of religion while growing up</td><td>736 (62.5)</td><td>334 (68.5)</td><td>402 (58.2)</td><td><.001</td></tr><tr><td> </td><td>Minor role of religion while growing up</td><td>443 (37.5)</td><td>154 (31.5)</td><td>289 (41.8)</td><td> </td></tr><tr><td>Area of growing up</td><td>Urban</td><td>610 (51.7)</td><td>272 (56.0)</td><td>338 (48.8)</td><td>.009</td></tr><tr><td> </td><td>Rural</td><td>569 (48.3)</td><td>214 (44.0)</td><td>355 (51.2)</td><td> </td></tr><tr><td>Alcohol use in the last 12 months</td><td>Abstainers of alcohol</td><td>520 (46.8)</td><td>240 (54.3)</td><td>280 (41.9)</td><td><.001</td></tr><tr><td> </td><td>Seldom users of alcohol in last 12 months</td><td>450 (40.5)</td><td>163 (36.9)</td><td>287 (43)</td><td> </td></tr><tr><td> </td><td>Frequent users of alcohol in last 12 months</td><td>140 (12.6)</td><td>39 (8.8)</td><td>101 (15.1)</td><td> </td></tr><tr><td> </td><td>Missing</td><td>69</td><td>44</td><td>25</td><td> </td></tr><tr><td>Alcohol use in relation to sexual activity*</td><td>Non-Use of alcohol in relation to sexual activity</td><td>391 (79)</td><td>146 (83.4)</td><td>245 (76.6)</td><td>.002</td></tr><tr><td> </td><td>Use of alcohol in relation to sexual activity</td><td>104 (21)</td><td>29 (16.6)</td><td>75 (23.4)</td><td> </td></tr><tr><td> </td><td>Missing</td><td>95</td><td>27</td><td>68</td><td> </td></tr><tr><td>Alcohol use at latest occasion of sexual intercourse*</td><td>Non-Use of alcohol at latest occasion of sexual intercourse</td><td>360 (72.9)</td><td>133 (76.9)</td><td>227 (70.7)</td><td>.001</td></tr><tr><td> </td><td>Use of alcohol at latest occasion of sexual intercourse</td><td>134 (27.1)</td><td>40 (23.1)</td><td>94 (29.3)</td><td> </td></tr><tr><td> </td><td>Missing</td><td>96</td><td>29</td><td>67</td><td> </td></tr><tr><td>Condom use with new partner</td><td>Consistent use of condom with new partner</td><td>603 (57.8)</td><td>216 (50.8)</td><td>387 (62.6)</td><td><.001</td></tr><tr><td> </td><td>Inconsistent condom use with new partner</td><td>440 (42.2)</td><td>209 (49.2)</td><td>231 (37.4)</td><td> </td></tr><tr><td> </td><td>Missing</td><td>136</td><td>61</td><td>75</td><td> </td></tr><tr><td>Number of sexual partners in past 12 months</td><td>0-1 sexual partner in last 12 months</td><td>680 (66.4)</td><td>324 (77.5)</td><td>356 (58.5)</td><td><.001</td></tr><tr><td> </td><td>2 or more sexual partners in last 12 months</td><td>344 (33.6)</td><td>94 (22.4)</td><td>250 (41.3)</td><td> </td></tr><tr><td> </td><td>Missing</td><td>155</td><td>68</td><td>87</td><td> </td></tr></table>
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<table><tr><td>Variables</td><td>Characteristics</td><td>All (N = 1179)</td><td>Females (N = 486)</td></tr><tr><td></td><td></td><td>n (%)</td><td>n (%)</td></tr><tr><td>Age</td><td>Younger (β€ 22 years)</td><td>608 (51.6)</td><td>215 (44.0)</td></tr><tr><td></td><td>Older (> 22 years)</td><td>571 (48.4)</td><td>271 (56.0)</td></tr><tr><td>Role of religion while growing up</td><td>Major role of religion while growing up</td><td>736 (62.5)</td><td>334 (68.5)</td></tr><tr><td></td><td>Minor role of religion while growing up</td><td>443 (37.5)</td><td>154 (31.5)</td></tr><tr><td>Area of growing up</td><td>Urban</td><td>610 (51.7)</td><td>272 (56.0)</td></tr><tr><td></td><td>Rural</td><td>569 (48.3)</td><td>214 (44.0)</td></tr><tr><td>Alcohol use in the last 12 months</td><td>Abstainers of alcohol</td><td>520 (46.8)</td><td>240 (54.3)</td></tr><tr><td></td><td>Seldom users of alcohol in last 12 months</td><td>450 (40.5)</td><td>163 (36.9)</td></tr><tr><td></td><td>Frequent users of alcohol in last 12 months</td><td>140 (12.6)</td><td>39 (8.8)</td></tr><tr><td></td><td>Missing</td><td>69</td><td>44</td></tr><tr><td>Alcohol use in relation to sexual activity*</td><td>Non-Use of alcohol in relation to sexual activity</td><td>391 (79)</td><td>146 (83.4)</td></tr><tr><td></td><td>Use of alcohol in relation to sexual activity</td><td>104 (21)</td><td>29 (16.6)</td></tr><tr><td></td><td>Missing</td><td>95</td><td>27</td></tr><tr><td>Alcohol use at latest occasion of sexual intercourse*</td><td>Non-Use of alcohol at latest occasion of sexual intercourse</td><td>360 (72.9)</td><td>133 (76.9)</td></tr><tr><td></td><td>Use of alcohol at latest occasion of sexual intercourse</td><td>134 (27.1)</td><td>40 (23.1)</td></tr><tr><td></td><td>Missing</td><td>96</td><td>29</td></tr><tr><td>Condom use with new partner</td><td>Consistent use of condom with new partner</td><td>603 (57.8)</td><td>216 (50.8)</td></tr><tr><td></td><td>Inconsistent condom use with new partner</td><td>440 (42.2)</td><td>209 (49.2)</td></tr><tr><td></td><td>Missing</td><td>136</td><td>61</td></tr><tr><td>Number of sexual partners in past 12 months</td><td>0-1 sexual partner in last 12 months</td><td>680 (66.4)</td><td>324 (77.5)</td></tr><tr><td></td><td>2 or more sexual partners in last 12 months</td><td>344 (33.6)</td><td>94 (22.4)</td></tr><tr><td></td><td>Missing</td><td>155</td><td>68</td></tr></table>
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<table><tr><td>Males (N = 693)</td><td>Chi-square</td></tr><tr><td>n (%)</td><td>(p-value)</td></tr><tr><td>393 (56.9)</td><td><.001</td></tr><tr><td>300 (43.1)</td><td></td></tr><tr><td>402 (58.2)</td><td><.001</td></tr><tr><td>289 (41.8)</td><td></td></tr><tr><td>338 (48.8)</td><td>.009</td></tr><tr><td>355 (51.2)</td><td></td></tr><tr><td>280 (41.9)</td><td><.001</td></tr><tr><td>287 (43)</td><td></td></tr><tr><td>101 (15.1)</td><td></td></tr><tr><td>25</td><td></td></tr><tr><td>245 (76.6)</td><td>.002</td></tr><tr><td>75 (23.4)</td><td></td></tr><tr><td>68</td><td></td></tr><tr><td>227 (70.7)</td><td>.001</td></tr><tr><td>94 (29.3)</td><td></td></tr><tr><td>67</td><td></td></tr><tr><td>387 (62.6)</td><td><.001</td></tr><tr><td>231 (37.4)</td><td></td></tr><tr><td>75</td><td></td></tr><tr><td>356 (58.5)</td><td><.001</td></tr><tr><td>250 (41.3)</td><td></td></tr><tr><td>87</td><td></td></tr></table>
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494f9a4a5c64f061fe0b03c4c13b43f65054923babb036937bb55ff79dba0d93.png
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complex
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<table><tr><td rowspan="2">PYD Measure</td><td>Before</td><td>After</td><td rowspan="2">Change</td><td rowspan="2">95% CI</td><td rowspan="2"><i>t (p)</i></td></tr><tr><td>Mean (SD)</td><td>Mean (SD)</td></tr><tr><td>Caring</td><td>69.99 (16.67)</td><td>71.49 (18.55)</td><td>1.51</td><td>−7.71, 10.73</td><td>0.34 (0.74)</td></tr><tr><td>Character</td><td>77.30 (15.96)</td><td>75.33 (9.70 )</td><td>- 1.97</td><td>−9.75, 5.81</td><td>−0.53 (0.60)</td></tr><tr><td>Competence</td><td>69.73 (16.24)</td><td>69.27 (9.87)</td><td>- 0.46</td><td>- 6.79, 5.86</td><td>−0.15 (0.88)</td></tr><tr><td>Connection</td><td>78.24 (11.00)</td><td>77.67 (9.94)</td><td>- 0.57</td><td>−6.44, 5.31</td><td>−0.20 (0.84)</td></tr><tr><td>Confidence</td><td>82.58 (12.87)</td><td>74.69 (12.79)</td><td>−7.89</td><td>−16.09, 0.30</td><td>−2.02 (0.06)</td></tr></table>
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<table><tr><td rowspan="2">PYD Measure</td><td>Before</td><td>After</td><td rowspan="2">Change</td><td rowspan="2">95% CI</td><td rowspan="2">t (p)</td></tr><tr><td>Mean (SD)</td><td>Mean (SD)</td></tr><tr><td>Caring</td><td>69.99 (16.67)</td><td>71.49 (18.55)</td><td>1.51</td><td>β7.71, 10.73</td><td>0.34 (0.74)</td></tr><tr><td>Character</td><td>77.30 (15.96)</td><td>75.33 (9.70 )</td><td>- 1.97</td><td>β9.75, 5.81</td><td>β0.53 (0.60)</td></tr><tr><td>Competence</td><td>69.73 (16.24)</td><td>69.27 (9.87)</td><td>- 0.46</td><td>- 6.79, 5.86</td><td>β0.15 (0.88)</td></tr></table>
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<table><tr><td>Connection</td><td>78.24 (11.00)</td><td>77.67 (9.94)</td><td>- 0.57</td><td>β6.44, 5.31</td><td>β0.20 (0.84)</td></tr><tr><td>Confidence</td><td>82.58 (12.87)</td><td>74.69 (12.79)</td><td>β7.89</td><td>β16.09, 0.30</td><td>β2.02 (0.06)</td></tr></table>
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5be2e0c1fdaae6cd62d675dbf1c7056cfb1c86d60375d9460c854683bf958820.png
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complex
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<table><tr><td></td><td colspan="2">Control group (<i>N</i> = 23)</td><td colspan="2">CBT group (<i>N</i> = 25)</td><td colspan="2">CBT with drink group (<i>N</i> = 24)</td><td></td></tr><tr><td></td><td>Mean</td><td>SD</td><td>Mean</td><td>SD</td><td>Mean</td><td>SD</td><td>F-values</td></tr><tr><td>POMS-TA</td><td>10.09</td><td>5.23</td><td>14.84</td><td>8.76</td><td>13.83</td><td>7.23</td><td>2.81<sup>†</sup></td></tr><tr><td>POMS-D</td><td>7.09</td><td>8.49</td><td>11.96</td><td>12.32</td><td>12.04</td><td>11.55</td><td>1.57</td></tr><tr><td>POMS-F</td><td>5.35a</td><td>4.09</td><td>9.84b</td><td>7.00</td><td>12.54c</td><td>7.01</td><td>7.99** a < b*, a < c**</td></tr><tr><td>SSAS</td><td>26.26</td><td>6.74</td><td>27.00</td><td>7.22</td><td>29.46</td><td>5.29</td><td>1.59</td></tr><tr><td>MSCL</td><td>1.78</td><td>2.04</td><td>1.92</td><td>2.27</td><td>3.17</td><td>2.35</td><td>2.79<sup>†</sup></td></tr><tr><td>GSES</td><td>9.87</td><td>3.44</td><td>7.84</td><td>4.45</td><td>8.67</td><td>4.21</td><td>1.50</td></tr></table>
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<table><tr><td></td><td colspan="2">Control group (N = 23)</td><td colspan="2">CBT group (N = 25)</td><td colspan="2">CBT with drink group (N = 24)</td><td></td></tr><tr><td></td><td>Mea</td><td>S</td><td>Me</td><td>SD</td><td>M</td><td>SD</td><td>F-values</td></tr></table>
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<table><tr><td></td><td>n</td><td>D</td><td>an</td><td></td><td>ean</td><td></td><td></td></tr><tr><td>POMS-TA</td><td>10.09</td><td>5.23</td><td>14.84</td><td>8.76</td><td>13.83</td><td>7.23</td><td>2.81β </td></tr><tr><td>POMS-D</td><td>7.09</td><td>8.49</td><td>11.96</td><td>12.32</td><td>12.04</td><td>11.55</td><td>1.57</td></tr><tr><td>POMS-F</td><td>5.35a</td><td>4.09</td><td>9.84b</td><td>7.00</td><td>12.54c</td><td>7.01</td><td>7.99** a < b*, a < c**</td></tr><tr><td>SSAS</td><td>26.26</td><td>6.74</td><td>27.00</td><td>7.22</td><td>29.46</td><td>5.29</td><td>1.59</td></tr><tr><td>MSCL</td><td>1.78</td><td>2.04</td><td>1.92</td><td>2.27</td><td>3.17</td><td>2.35</td><td>2.79β </td></tr><tr><td>GSES</td><td>9.87</td><td>3.44</td><td>7.84</td><td>4.45</td><td>8.67</td><td>4.21</td><td>1.50</td></tr></table>
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1c7434855d73824a0d8f239a3b644b0eba8207a1901e1f8289fff86e2ba45cad.png
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simple
|
<table><tr><td></td><td>All patients (<i>n</i> = 121)</td><td>mRS = 0–1 (<i>n</i> = 75)</td><td>mRS = 2–6 (<i>n</i> = 46)</td><td><i>P</i>-value</td></tr><tr><td>Age (mean ± SD)</td><td>63.4 ± 11.3</td><td>63.2 ± 10.5</td><td>63.8 ± 12.6</td><td>0.769</td></tr><tr><td>Sex, <i>n</i>(%)</td><td></td><td></td><td></td><td>0.490</td></tr><tr><td> Men</td><td>85(70.2)</td><td>51(68)</td><td>34(73.9)</td><td></td></tr><tr><td> Female</td><td>36(29.8)</td><td>24(32)</td><td>12(26.1)</td><td></td></tr><tr><td>Risk factor, n(%)</td><td></td><td></td><td></td><td></td></tr><tr><td> Hypertension</td><td>61(50.8)</td><td>36(48.6)</td><td>25(54.3)</td><td>0.544</td></tr><tr><td> Diabetes</td><td>33(27.3)</td><td>14(18.7)</td><td>19(41.3)</td><td>0.007</td></tr><tr><td> Hyperlipidemia</td><td>17(14)</td><td>7(9.3)</td><td>10(21.7)</td><td>0.057</td></tr><tr><td> Atrial fibrillation</td><td>22(18.2)</td><td>16(21.3)</td><td>6(13)</td><td>0.251</td></tr><tr><td> Current smoking</td><td>31(25.6)</td><td>20(26.7)</td><td>11(23.9)</td><td>0.736</td></tr><tr><td> Previous coronary artery disease</td><td>14(11.6)</td><td>10(13.3)</td><td>4(8.7)</td><td>0.564</td></tr><tr><td> Previous stroke or TIA</td><td>11(9.1)</td><td>6(8.0)</td><td>5(10.9)</td><td>0.746</td></tr><tr><td>NIHSS on admission, (med, IQR)</td><td>4[3–5]</td><td>4[2–4]</td><td>4[3–5]</td><td>0.003</td></tr><tr><td>(mean ± SD)</td><td>3.6 ± 1.2</td><td>3.4 ± 1.2</td><td>4.0 ± 1.1</td><td>0.004</td></tr><tr><td>Onset to rt-PA time, (mean± SD)</td><td>143.1 ± 61.4</td><td>141.6 ± 57.9</td><td>145.6 ± 67.2</td><td>0.728</td></tr><tr><td>Blood glucose on admission, mg/dL</td><td>143.4 ± 52.6</td><td>134.7 ± 44.9</td><td>157.6 ± 61.0</td><td>0.019</td></tr><tr><td>Initial systolic blood pressure, mmHg</td><td>145.6 ± 26.3</td><td>145.4 ± 27.9</td><td>145.8 ± 23.5</td><td>0.924</td></tr><tr><td>Etiologic stroke subtypes, <i>n</i>(%)</td><td></td><td></td><td></td><td>0.302</td></tr><tr><td> Small vessel disease</td><td>25(20.7)</td><td>13(17.3)</td><td>12(26.1)</td><td>0.248</td></tr><tr><td> Large artery disease</td><td>36(29.8)</td><td>22(29.3)</td><td>14(30.4)</td><td>0.298</td></tr><tr><td> Cardiac embolism</td><td>34(28.1)</td><td>26(34.7)</td><td>8(17.4)</td><td>0.040</td></tr><tr><td> Undetermined etiology</td><td>26(21.5)</td><td>14(18.7)</td><td>12(26.1)</td><td>0.335</td></tr><tr><td>Lesions on pretreatment DWI, <i>n</i>(%)</td><td></td><td></td><td></td><td>0.317</td></tr><tr><td> Acute infarcts (+)</td><td>110(91.7)</td><td>67(89.3)</td><td>43(95.6)</td><td></td></tr><tr><td> No lesions</td><td>10(8.3)</td><td>8(10.7)</td><td>2(4.4)</td><td></td></tr><tr><td>Lesion patterns on DWI, <i>n</i>(%)</td><td></td><td></td><td></td><td></td></tr><tr><td> Perforating artery infarcts</td><td>27(22.3)</td><td>12(16)</td><td>15(32.6)</td><td>0.033</td></tr><tr><td> Pial infarcts</td><td>51(42.1)</td><td>40(53.3)</td><td>11(23.9)</td><td>0.001</td></tr><tr><td> Borderzone infarcts</td><td>6(5)</td><td>5(6.7)</td><td>1(2.2)</td><td>0.406</td></tr><tr><td> Territorial infarcts</td><td>17(14)</td><td>10(13.3)</td><td>7(15.2)</td><td>0.772</td></tr><tr><td> Perforating artery infarcts plus</td><td>20(16.5)</td><td>8(10.7)</td><td>12(26.1)</td><td>0.027</td></tr><tr><td>Deep MCA infarcts (PAI + PAI plus)</td><td>47(38.8)</td><td>20(26.7)</td><td>27(58.7)</td><td>< 0.001</td></tr><tr><td>Angiographic findings of relevant artery, <i>n</i>(%)</td><td></td><td></td><td></td><td>0.383</td></tr><tr><td> No stenosis or occlusion</td><td>62(51.2)</td><td>42(56)</td><td>20(43.5)</td><td></td></tr><tr><td> Stenosis (> 50%)</td><td>19(15.7)</td><td>10(13.3)</td><td>9(19.6)</td><td></td></tr><tr><td> Occlusion</td><td>40(33.1)</td><td>23(30.7)</td><td>17(37)</td><td></td></tr><tr><td>Steno-occlusive disease, <i>n</i>(%)</td><td>59(48.8)</td><td>33(44)</td><td>26(56.5)</td><td>0.181</td></tr><tr><td>END, <i>n</i>(%)</td><td>14(11.6)</td><td>3(4)</td><td>11(23.9)</td><td>0.002</td></tr><tr><td>Symptomatic ICH, <i>n</i>(%)</td><td>2(1.7)</td><td>1(1.3)</td><td>1(2.2)</td><td>1.000</td></tr></table>
|
<table><tr><td></td><td>All patients (n = 121)</td><td>mRS = 0β1 (n = 75)</td><td>mRS = 2β6 (n = 46)</td><td>P-value</td></tr><tr><td>Age (mean Β± SD)</td><td>63.4 Β± 11.3</td><td>63.2 Β± 10.5</td><td>63.8 Β± 12.6</td><td>0.769</td></tr><tr><td>Sex, n(%)</td><td></td><td></td><td></td><td>0.490</td></tr><tr><td>Men</td><td>85(70.2)</td><td>51(68)</td><td>34(73.9)</td><td></td></tr><tr><td>Female</td><td>36(29.8)</td><td>24(32)</td><td>12(26.1)</td><td></td></tr><tr><td>Risk factor, n(%)</td><td></td><td></td><td></td><td></td></tr><tr><td>Hypertension</td><td>61(50.8)</td><td>36(48.6)</td><td>25(54.3)</td><td>0.544</td></tr><tr><td>Diabetes</td><td>33(27.3)</td><td>14(18.7)</td><td>19(41.3)</td><td>0.007</td></tr><tr><td>Hyperlipidemia</td><td>17(14)</td><td>7(9.3)</td><td>10(21.7)</td><td>0.057</td></tr><tr><td>Atrial fibrillation</td><td>22(18.2)</td><td>16(21.3)</td><td>6(13)</td><td>0.251</td></tr><tr><td>Current smoking</td><td>31(25.6)</td><td>20(26.7)</td><td>11(23.9)</td><td>0.736</td></tr><tr><td>Previous coronary artery disease</td><td>14(11.6)</td><td>10(13.3)</td><td>4(8.7)</td><td>0.564</td></tr><tr><td>Previous stroke or TIA</td><td>11(9.1)</td><td>6(8.0)</td><td>5(10.9)</td><td>0.746</td></tr><tr><td>NIHSS on admission, (med, IQR)</td><td>4[3β5]</td><td>4[2β4]</td><td>4[3β5]</td><td>0.003</td></tr><tr><td>(mean Β± SD)</td><td>3.6 Β± 1.2</td><td>3.4 Β± 1.2</td><td>4.0 Β± 1.1</td><td>0.004</td></tr><tr><td>Onset to rt-PA time, (meanΒ± SD)</td><td>143.1 Β± 61.4</td><td>141.6 Β± 57.9</td><td>145.6 Β± 67.2</td><td>0.728</td></tr><tr><td>Blood glucose on admission, mg/dL</td><td>143.4 Β± 52.6</td><td>134.7 Β± 44.9</td><td>157.6 Β± 61.0</td><td>0.019</td></tr><tr><td>Initial systolic blood pressure, mmHg</td><td>145.6 Β± 26.3</td><td>145.4 Β± 27.9</td><td>145.8 Β± 23.5</td><td>0.924</td></tr><tr><td>Etiologic stroke subtypes, n(%)</td><td></td><td></td><td></td><td>0.302</td></tr><tr><td>Small vessel disease</td><td>25(20.7)</td><td>13(17.3)</td><td>12(26.1)</td><td>0.248</td></tr><tr><td>Large artery disease</td><td>36(29.8)</td><td>22(29.3)</td><td>14(30.4)</td><td>0.298</td></tr><tr><td>Cardiac embolism</td><td>34(28.1)</td><td>26(34.7)</td><td>8(17.4)</td><td>0.040</td></tr><tr><td>Undetermined etiology</td><td>26(21.5)</td><td>14(18.7)</td><td>12(26.1)</td><td>0.335</td></tr><tr><td>Lesions on pretreatment DWI, n(%)</td><td></td><td></td><td></td><td>0.317</td></tr><tr><td>Acute infarcts (+)</td><td>110(91.7)</td><td>67(89.3)</td><td>43(95.6)</td><td></td></tr><tr><td>No lesions</td><td>10(8.3)</td><td>8(10.7)</td><td>2(4.4)</td><td></td></tr><tr><td>Lesion patterns on DWI, n(%)</td><td></td><td></td><td></td><td></td></tr><tr><td>Perforating artery infarcts</td><td>27(22.3)</td><td>12(16)</td><td>15(32.6)</td><td>0.033</td></tr><tr><td>Pial</td><td>51(4</td><td>40(53</td><td>11</td><td></td></tr></table>
|
<table><tr><td> infarcts</td><td>2.1)</td><td>.3)</td><td>(23.9)</td><td>0.001</td></tr><tr><td>Borderzone infarcts</td><td>6(5)</td><td>5(6.7)</td><td>1(2.2)</td><td>0.406</td></tr><tr><td>Territorial infarcts</td><td>17(14)</td><td>10(13.3)</td><td>7(15.2)</td><td>0.772</td></tr><tr><td>Perforating artery infarcts plus</td><td>20(16.5)</td><td>8(10.7)</td><td>12(26.1)</td><td>0.027</td></tr><tr><td>Deep MCA infarcts (PAI + PAI plus)</td><td>47(38.8)</td><td>20(26.7)</td><td>27(58.7)</td><td>< 0.001</td></tr><tr><td>Angiographic findings of relevant artery, n(%)</td><td></td><td></td><td></td><td>0.383</td></tr><tr><td>No stenosis or occlusion</td><td>62(51.2)</td><td>42(56)</td><td>20(43.5)</td><td></td></tr><tr><td>Stenosis (> 50%)</td><td>19(15.7)</td><td>10(13.3)</td><td>9(19.6)</td><td></td></tr><tr><td>Occlusion</td><td>40(33.1)</td><td>23(30.7)</td><td>17(37)</td><td></td></tr><tr><td>Steno-occlusive disease, n(%)</td><td>59(48.8)</td><td>33(44)</td><td>26(56.5)</td><td>0.181</td></tr><tr><td>END, n(%)</td><td>14(11.6)</td><td>3(4)</td><td>11(23.9)</td><td>0.002</td></tr><tr><td>Symptomatic ICH, n(%)</td><td>2(1.7)</td><td>1(1.3)</td><td>1(2.2)</td><td>1.000</td></tr></table>
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9c80594295453e726f84a3b6f249c279e93a2df436a5b7b24feb763c5c71eb89.png
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simple
|
<table><tr><td>Device</td><td>Magnitude (%)</td><td>Phase (min)</td></tr><tr><td>Inductive voltage divider</td><td>0.0002</td><td>0.069</td></tr><tr><td>Shunt</td><td>0.01</td><td>0.3</td></tr><tr><td>DMM</td><td>0.01</td><td>0.583</td></tr></table>
|
<table><tr><td>Device</td><td>Magnitude (%)</td><td>Phase (min)</td></tr></table>
|
<table><tr><td>Inductive voltage divider</td><td>0.0002</td><td>0.069</td></tr><tr><td>Shunt</td><td>0.01</td><td>0.3</td></tr><tr><td>DMM</td><td>0.01</td><td>0.583</td></tr></table>
|
0f09d194f8c059fed4cc943896aa5649c87cfb5dc41f440d607839d63f3dc8d4.png
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simple
|
<table><tr><td></td><td>Moroccan N = 14,490</td><td>Turkish N = 10,316</td><td>Surinamese N = 8,619</td><td>Moluccan N = 1,064</td><td>Dutch N = 33,725</td><td><i>p</i>-value</td></tr><tr><td>Total costs (mean, SE)</td><td>3049.8 (67.3)<sup>4</sup></td><td>3149.4 (79.6)<sup>4</sup></td><td>3843.4 (87.2)<sup>4</sup></td><td>2300.0 (247.9)<sup>4</sup></td><td>3473.3 (44.0)</td><td><0.0001</td></tr><tr><td>GP services (mean, SE)<sup>5</sup></td><td>56.8 (0.5)<sup>4</sup></td><td>58.7 (0.6)<sup>4</sup></td><td>60.8 (0.6)<sup>4</sup></td><td>42.0 (1.8)<sup>4</sup></td><td>48.7 (0.3)</td><td><0.0001</td></tr><tr><td>Receipt of prescriptions (mean, SE)<sup>6</sup></td><td>819.4 (15.8)<sup>4</sup></td><td>855.8 (18.7)<sup>4</sup></td><td>871.2 (20.5)<sup>4</sup></td><td>545.9 (58.3)<sup>4</sup></td><td>727.2 (10.4)</td><td><0.0001</td></tr><tr><td>Physical therapy (mean, SE)<sup>7</sup></td><td>141.3 (3.4)<sup>4</sup></td><td>139.3 (4.1)<sup>4</sup></td><td>186.4 (4.5)</td><td>122.5 (12.7)<sup>4</sup></td><td>176.7 (2.3)</td><td><0.0001</td></tr><tr><td>Hospital services (mean, SE)<sup>8</sup></td><td>1854.3 (59.6)<sup>4</sup></td><td>1922.7 (70.5)<sup>4</sup></td><td>2478.0 (77.2)</td><td>1472.1 (219.5)<sup>4</sup></td><td>2303.6 (39.0)</td><td><0.0001</td></tr><tr><td>Medical aids (mean, SE)<sup>9</sup></td><td>178.1 (6.5)<sup>4</sup></td><td>172.9 (7.7)<sup>4</sup></td><td>247.0 (8.4)<sup>4</sup></td><td>117.4 (24.0)<sup>4</sup></td><td>217.2 (4.3)</td><td><0.0001</td></tr></table>
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<table><tr><td></td><td>Moroccan N = 14,490</td><td>Turkish N = 10,316</td><td>Surinamese N = 8,619</td><td>Moluccan N = 1,064</td><td>Dutch N = 33,725</td><td>p-value</td></tr><tr><td>Total costs (mean, SE)</td><td>3049.8 (67.3)4</td><td>3149.4 (79.6)4</td><td>3843.4 (87.2)4</td><td>2300.0 (247.9)4</td><td>3473.3 (44.0)</td><td><0.0001</td></tr><tr><td>GP services (mean, SE)5</td><td>56.8 (0.5)4</td><td>58.7 (0.6)4</td><td>60.8 (0.6)4</td><td>42.0 (1.8)4</td><td>48.7 (0.3)</td><td><0.0001</td></tr><tr><td>Receipt of prescriptions (mean, SE)6</td><td>819.4 (15.8)4</td><td>855.8 (18.7)4</td><td>871.2 (20.5)4</td><td>545.9 (58.3)4</td><td>727.2 (10.4)</td><td><0.0001</td></tr></table>
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<table><tr><td>Physical therapy (mean, SE)7</td><td>141.3 (3.4)4</td><td>139.3 (4.1)4</td><td>186.4 (4.5)</td><td>122.5 (12.7)4</td><td>176.7 (2.3)</td><td><0.0001</td></tr><tr><td>Hospital services (mean, SE)8</td><td>1854.3 (59.6)4</td><td>1922.7 (70.5)4</td><td>2478.0 (77.2)</td><td>1472.1 (219.5)4</td><td>2303.6 (39.0)</td><td><0.0001</td></tr><tr><td>Medical aids (mean, SE)9</td><td>178.1 (6.5)4</td><td>172.9 (7.7)4</td><td>247.0 (8.4)4</td><td>117.4 (24.0)4</td><td>217.2 (4.3)</td><td><0.0001</td></tr></table>
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1b4a8482710ba607e4a44e169222b2936370709368d1e050a0137a7def668088.png
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complex
|
<table><tr><td rowspan="2">Year</td><td colspan="5">Host age</td></tr><tr><td>Site</td><td><i>N</i></td><td>1</td><td>2</td><td>3</td></tr><tr><td rowspan="3">2002</td><td>Urwitałt</td><td>64</td><td>0.0 (0.0–23.8)</td><td>0.0 (0.0–13.4)</td><td>0.0 (0.0–13.4)</td></tr><tr><td>Tałty</td><td>70</td><td>4.5 (0.2–22.2)</td><td>6.5 (1.9–17.4)</td><td>17.6 (5.0–41.7)</td></tr><tr><td>Pilchy</td><td>69</td><td>0.0 (0.0–17.6)</td><td>11.5 (3.2–30.4)</td><td>8.3 (1.5–26.7)</td></tr><tr><td>Overall by year</td><td></td><td>203</td><td></td><td></td><td>5.4 (3.7–7.8)</td></tr><tr><td rowspan="3">2006</td><td>Urwitałt</td><td>95</td><td>7.7 (1.4–24.6)</td><td>4.5 (0.7–17.7)</td><td>4.0 (0.2–19.6)</td></tr><tr><td>Tałty</td><td>65</td><td>7.7 (1.4–24.6)</td><td>0.0 (0.0–22.2)</td><td>12.5 (3.5–31.0)</td></tr><tr><td>Pilchy</td><td>67</td><td>24.1 (11.5–43.0)</td><td>38.5 (16.6–65.8)</td><td>76.0 (56.1–89.0)</td></tr><tr><td>Overall by year</td><td></td><td>227</td><td></td><td></td><td>18.1 (14.7–21.9)</td></tr><tr><td rowspan="3">2010</td><td>Urwitałt</td><td>86</td><td>0.0 (0.0–20.8)</td><td>25.0 (12.9–41.9)</td><td>11.5 (3.2–30.4)</td></tr><tr><td>Tałty</td><td>96</td><td>11.5 (3.2–30.4)</td><td>13.0 (3.7–32.4)</td><td>19.1 (8.8–36.6)</td></tr><tr><td>Pilchy</td><td>56</td><td>11.8 (2.1–35.0)</td><td>50.0 (24.3–75.7)</td><td>32.1 (23.2–42.6)</td></tr><tr><td>Overall by year</td><td></td><td>238</td><td></td><td></td><td>19.7 (16.2–23.8)</td></tr><tr><td>Overall by age</td><td></td><td></td><td>8.7 (4.4–16.0)</td><td>13.7 (10.8–17.3)</td><td>20.8 (17.2–24.9)</td></tr><tr><td>Overall</td><td></td><td>668</td><td></td><td></td><td>14.8 (12.5–17.5)</td></tr></table>
|
<table><tr><td rowspan="2">Year</td><td colspan="3">Host age</td></tr><tr><td>Site</td><td>N</td><td>1</td></tr><tr><td rowspan="3">2002</td><td>UrwitaΕt</td><td>64</td><td>0.0 (0.0β23.8)</td></tr><tr><td>TaΕty</td><td>70</td><td>4.5 (0.2β22.2)</td></tr><tr><td>Pilchy</td><td>69</td><td>0.0 (0.0β17.6)</td></tr><tr><td>Overall by year</td><td></td><td>203</td><td></td></tr><tr><td rowspan="3">2006</td><td>UrwitaΕt</td><td>95</td><td>7.7 (1.4β24.6)</td></tr><tr><td>TaΕty</td><td>65</td><td>7.7 (1.4β24.6)</td></tr><tr><td>Pilchy</td><td>67</td><td>24.1 (11.5β43.0)</td></tr><tr><td>Overall by year</td><td></td><td>227</td><td></td></tr><tr><td rowspan="3">2010</td><td>UrwitaΕt</td><td>86</td><td>0.0 (0.0β20.8)</td></tr><tr><td>TaΕty</td><td>96</td><td>11.5 (3.2β30.4)</td></tr><tr><td>Pilchy</td><td>56</td><td>11.8 (2.1β35.0)</td></tr><tr><td>Overall by year</td><td></td><td>238</td><td></td></tr><tr><td>Overall by age</td><td></td><td></td><td>8.7 (4.4β16.0)</td></tr><tr><td>Overall</td><td></td><td>668</td><td></td></tr></table>
|
<table><tr><td colspan="2">Host age</td></tr><tr><td>2</td><td>3</td></tr><tr><td>0.0 (0.0β13.4)</td><td>0.0 (0.0β13.4)</td></tr><tr><td>6.5 (1.9β17.4)</td><td>17.6 (5.0β41.7)</td></tr><tr><td>11.5 (3.2β30.4)</td><td>8.3 (1.5β26.7)</td></tr><tr><td></td><td>5.4 (3.7β7.8)</td></tr><tr><td>4.5 (0.7β17.7)</td><td>4.0 (0.2β19.6)</td></tr><tr><td>0.0 (0.0β22.2)</td><td>12.5 (3.5β31.0)</td></tr><tr><td>38.5 (16.6β65.8)</td><td>76.0 (56.1β89.0)</td></tr><tr><td></td><td>18.1 (14.7β21.9)</td></tr><tr><td>25.0 (12.9β41.9)</td><td>11.5 (3.2β30.4)</td></tr><tr><td>13.0 (3.7β32.4)</td><td>19.1 (8.8β36.6)</td></tr><tr><td>50.0 (24.3β75.7)</td><td>32.1 (23.2β42.6)</td></tr><tr><td></td><td>19.7 (16.2β23.8)</td></tr><tr><td>13.7 (10.8β17.3)</td><td>20.8 (17.2β24.9)</td></tr><tr><td></td><td>14.8 (12.5β17.5)</td></tr></table>
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3cbc413231e9d16ec0a3c8bdcab4b0727ffb2710f2344d16329af1d91a54081e.png
|
simple
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<table><tr><td></td><td></td><td>Cases(n)</td><td>Ref(n)</td><td>Odds ratio*</td><td>Confidence interval (95%)</td></tr><tr><td>Household economy</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Non-poor</td><td>Close</td><td>68</td><td>317</td><td>Ref</td><td></td></tr><tr><td></td><td>Remote</td><td>48</td><td>159</td><td>1.40</td><td>0.92 - 2.13</td></tr><tr><td>Poor</td><td>Close</td><td>10</td><td>41</td><td>Ref</td><td></td></tr><tr><td></td><td>Remote</td><td>54</td><td>80</td><td>2.84</td><td>1.30 - 6.21</td></tr><tr><td>Mother's ethnicity</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Kinh</td><td>Close</td><td>45</td><td>226</td><td>Ref</td><td></td></tr><tr><td></td><td>Remote</td><td>23</td><td>104</td><td>1.30</td><td>0.75 - 2.28</td></tr><tr><td>Minority</td><td>Close</td><td>33</td><td>92</td><td>Ref</td><td></td></tr><tr><td></td><td>Remote</td><td>79</td><td>135</td><td>1.61</td><td>0.99 - 2.62</td></tr><tr><td>Maternal education</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Completed1° school (≥5 y)</td><td>Close</td><td>68</td><td>325</td><td>Ref</td><td></td></tr><tr><td></td><td>Remote</td><td>46</td><td>165</td><td>0.84</td><td>0.86 - 2.01</td></tr><tr><td>Not completed1° school (<5 y)</td><td>Close</td><td>10</td><td>33</td><td>Ref</td><td></td></tr><tr><td></td><td>Remote</td><td>54</td><td>73</td><td>2.59</td><td>1.16 - 5.82</td></tr></table>
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<table><tr><td></td><td></td><td>Cases(n)</td><td>Ref(n)</td></tr><tr><td>Household economy</td><td></td><td></td><td></td></tr><tr><td>Non-poor</td><td>Close</td><td>68</td><td>317</td></tr><tr><td></td><td>Remote</td><td>48</td><td>159</td></tr><tr><td>Poor</td><td>Close</td><td>10</td><td>41</td></tr><tr><td></td><td>Remote</td><td>54</td><td>80</td></tr><tr><td>Mother's ethnicity</td><td></td><td></td><td></td></tr><tr><td>Kinh</td><td>Close</td><td>45</td><td>226</td></tr><tr><td></td><td>Remote</td><td>23</td><td>104</td></tr><tr><td>Minority</td><td>Close</td><td>33</td><td>92</td></tr><tr><td></td><td>Remote</td><td>79</td><td>135</td></tr><tr><td>Maternal education</td><td></td><td></td><td></td></tr><tr><td>Completed1Β° school (β₯5 y)</td><td>Close</td><td>68</td><td>325</td></tr><tr><td></td><td>Remote</td><td>46</td><td>165</td></tr><tr><td>Not completed1Β° school (<5 y)</td><td>Close</td><td>10</td><td>33</td></tr><tr><td></td><td>Remote</td><td>54</td><td>73</td></tr></table>
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<table><tr><td>Odds ratio*</td><td>Confidence interval (95%)</td></tr><tr><td></td><td></td></tr><tr><td>Ref</td><td></td></tr><tr><td>1.40</td><td>0.92 - 2.13</td></tr><tr><td>Ref</td><td></td></tr><tr><td>2.84</td><td>1.30 - 6.21</td></tr><tr><td></td><td></td></tr><tr><td>Ref</td><td></td></tr><tr><td>1.30</td><td>0.75 - 2.28</td></tr><tr><td>Ref</td><td></td></tr><tr><td>1.61</td><td>0.99 - 2.62</td></tr><tr><td></td><td></td></tr><tr><td>Ref</td><td></td></tr><tr><td>0.84</td><td>0.86 - 2.01</td></tr><tr><td>Ref</td><td></td></tr><tr><td>2.59</td><td>1.16 - 5.82</td></tr></table>
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72bb8858d46f3ecaa1ccb8e7bd4950c549d153e4b0de35a78547cd9ea4c960ae.png
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complex
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<table><tr><td></td><td></td><td colspan="4">Men</td><td colspan="4">Women</td></tr><tr><td></td><td></td><td colspan="2">IHD mortality</td><td colspan="2">Stroke mortality</td><td colspan="2">IHD mortality</td><td colspan="2">Stroke mortality</td></tr><tr><td></td><td>Median</td><td>Age-adjusted HR</td><td>Multivariate HRa</td><td>Age-adjusted HR</td><td>Multivariate HRa</td><td>Age-adjusted HR</td><td>Multivariate HRa</td><td>Age-adjusted HR</td><td>Multivariate HRa</td></tr><tr><td>Cases (<i>n</i>)</td><td></td><td>1,308</td><td>1,142</td><td>454</td><td>370</td><td>596</td><td>500</td><td>317</td><td>261</td></tr><tr><td>Person-years subcohort (<i>n</i>)</td><td></td><td>17,057</td><td>15,017</td><td>17,426</td><td>15,017</td><td>20,512</td><td>18,241</td><td>20,512</td><td>18,241</td></tr><tr><td colspan="10">Tap water characteristics</td></tr><tr><td colspan="10">Total water hardness (mmol/L)</td></tr><tr><td> ≤ 1.5 (soft)</td><td>1.1</td><td>1.00 (reference)</td><td>1.00 (reference)</td><td>1.00 (reference)</td><td>1.00 (reference)</td><td>1.00 (reference)</td><td>1.00 (reference)</td><td>1.00 (reference)</td><td>1.00 (reference)</td></tr><tr><td> 1.6–2 (medium hard)</td><td>1.7</td><td>1.07 (0.89–1.29)</td><td>0.96 (0.76–1.20)</td><td>0.89 (0.68–1.17)</td><td>0.81 (0.59–1.14)</td><td>1.16 (0.91–1.47)</td><td>1.24 (0.93–1.66)</td><td>0.81 (0.60–1.12)</td><td>0.92 (0.64–1.32)</td></tr><tr><td> > 2 (hard)</td><td>2.4</td><td>1.08 (0.91–1.29)</td><td>1.04 (0.85–1.28)</td><td>0.93 (0.73–1.19)</td><td>0.90 (0.66–1.21)</td><td>0.99 (0.79–1.23)</td><td>0.93 (0.71–1.21)</td><td>0.84 (0.64–1.11)</td><td>0.86 (0.62–1.20)</td></tr><tr><td> <i>p</i> for trend</td><td></td><td>0.34</td><td>0.69</td><td>0.58</td><td>0.46</td><td>0.90</td><td>0.58</td><td>0.22</td><td>0.37</td></tr><tr><td colspan="10">Calcium concentration (mg/L) </td></tr><tr><td colspan="10">Quintiles</td></tr><tr><td> 15–40</td><td>34.0</td><td>1.00 (reference)</td><td>1.00 (reference)</td><td>1.00 (reference)</td><td>1.00 (reference)</td><td>1.00 (reference)</td><td>1.00 (reference)</td><td>1.00 (reference)</td><td>1.00 (reference)</td></tr><tr><td> > 40–51</td><td>47.6</td><td>0.92 (0.74–1.14)</td><td>0.79 (0.59–1.06)</td><td>0.77 (0.57–1.06)</td><td>0.67 (0.44–1.03)</td><td>1.02 (0.78–1.34)</td><td>1.11 (0.77–1.61)</td><td>0.83 (0.59–1.16)</td><td>0.98 (0.62–1.55)</td></tr><tr><td> 53–64</td><td>57.5</td><td>1.05 (0.81–1.38)</td><td>0.87 (0.59–1.27)</td><td>1.03 (0.71–1.51)</td><td>1.14 (0.67–1.97)</td><td>1.31 (0.94–1.82)</td><td>1.49 (0.91–2.43)</td><td>0.91 (0.60–1.41)</td><td>1.12 (0.61–2.07)</td></tr><tr><td> > 64–81</td><td>80.0</td><td>1.05 (0.85–1.29)</td><td>0.91 (0.65–1.28)</td><td>0.81 (0.60–1.10)</td><td>0.80 (0.49–1.31)</td><td>1.01 (0.77–1.32)</td><td>1.15 (0.73–1.80)</td><td>0.73 (0.52–1.03)</td><td>0.86 (0.48–1.52)</td></tr><tr><td> 82–157</td><td>107.0</td><td>1.14 (0.87–1.47)</td><td>0.91 (0.60–1.38)</td><td>0.95 (0.65–1.38)</td><td>1.18 (0.62–2.22)</td><td>1.03 (0.74–1.43)</td><td>1.11 (0.59–2.07)</td><td>0.87 (0.57–1.31)</td><td>1.01 (0.47–2.19)</td></tr><tr><td> <i>p</i> for trend</td><td></td><td>0.19</td><td>0.88</td><td>0.69</td><td>0.66</td><td>0.85</td><td>0.75</td><td>0.22</td><td>0.71</td></tr><tr><td colspan="10">Magnesium concentration (mg/L) </td></tr><tr><td colspan="10">Quintiles</td></tr><tr><td> 1.7–3.8</td><td>3.4</td><td>1.00 (reference)</td><td>1.00 (reference)</td><td>1.00 (reference)</td><td>1.00 (reference)</td><td>1.00 (reference)</td><td>1.00 (reference)</td><td>1.00 (reference)</td><td>1.00 (reference)</td></tr><tr><td> 4.2–6.0</td><td>4.9</td><td>1.06 (0.84–1.34)</td><td>1.04 (0.76–1.42)</td><td>0.88 (0.64–1.23)</td><td>0.82 (0.53–1.29)</td><td>1.14 (0.85–1.53)</td><td>1.08 (0.73–1.58)</td><td>0.85 (0.58–1.24)</td><td>0.84 (0.52–1.35)</td></tr><tr><td> 6.0–8.0</td><td>7.3</td><td>1.10 (0.87–1.39)</td><td>1.21 (0.87–1.71)</td><td>0.70 (0.50–1.00)</td><td>0.80 (0.48–1.33)</td><td>0.87 (0.64–1.17)</td><td>0.75 (0.49–1.18)</td><td>0.86 (0.59–1.23)</td><td>0.84 (0.49–1.43)</td></tr><tr><td> > 8.0–8.2</td><td>8.1</td><td>0.97 (0.78–1.22)</td><td>0.95 (0.67–1.33)</td><td>0.84 (0.62–1.16)</td><td>0.87 (0.53–1.44)</td><td>1.14 (0.86–1.52)</td><td>0.97 (0.62–1.53)</td><td>1.02 (0.72–1.44)</td><td>1.10 (0.62–1.96)</td></tr><tr><td> 8.5–26.2</td><td>10.6</td><td>1.19 (0.93–1.53)</td><td>1.23 (0.82–1.86)</td><td>0.84 (0.59–1.20)</td><td>0.69 (0.37–1.31)</td><td>1.10 (0.81–1.50)</td><td>0.89 (0.50–1.59)</td><td>0.82 (0.55–1.23)</td><td>0.77 (0.38–1.57)</td></tr><tr><td> <i>p</i> for trend</td><td></td><td>0.43</td><td>0.71</td><td>0.29</td><td>0.44</td><td>0.55</td><td>0.66</td><td>0.70</td><td>0.97</td></tr></table>
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<table><tr><td></td><td></td><td colspan="4">Men</td><td colspan="4">Women</td></tr><tr><td></td><td></td><td colspan="2">IHD mortality</td><td colspan="2">Stroke mortality</td><td colspan="2">IHD mortality</td><td colspan="2">Stroke mortality</td></tr><tr><td></td><td>Median</td><td>Age-adjusted HR</td><td>Multivariate HRa</td><td>Age-adjusted HR</td><td>Multivariate HRa</td><td>Age-adjusted HR</td><td>Multivariate HRa</td><td>Age-adjusted HR</td><td>Multivariate HRa</td></tr><tr><td>Cases (n)</td><td></td><td>1,308</td><td>1,142</td><td>454</td><td>370</td><td>596</td><td>500</td><td>317</td><td>261</td></tr><tr><td>Person-years subcohort (n)</td><td></td><td>17,057</td><td>15,017</td><td>17,426</td><td>15,017</td><td>20,512</td><td>18,241</td><td>20,512</td><td>18,241</td></tr><tr><td colspan="10">Tap water characteristics</td></tr></table>
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<table><tr><td></td><td></td><td colspan="4">Men</td><td colspan="4">Women</td></tr><tr><td></td><td></td><td colspan="2">IHD mortality</td><td colspan="2">Stroke mortality</td><td colspan="2">IHD mortality</td><td colspan="2">Stroke mortality</td></tr><tr><td></td><td>Median</td><td>Age-adjusted HR</td><td>Multivariate HRa</td><td>Age-adjusted HR</td><td>Multivariate HRa</td><td>Age-adjusted HR</td><td>Multivariate HRa</td><td>Age-adjusted HR</td><td>Multivariate HRa</td></tr><tr><td colspan="10">Total water hardness (mmol/L)</td></tr><tr><td>β€ 1.5 (soft)</td><td>1.1</td><td>1.00 (reference)</td><td>1.00 (reference)</td><td>1.00 (reference)</td><td>1.00 (reference)</td><td>1.00 (reference)</td><td>1.00 (reference)</td><td>1.00 (reference)</td><td>1.00 (reference)</td></tr><tr><td>1.6β2 (medium hard)</td><td>1.7</td><td>1.07 (0.89β1.29)</td><td>0.96 (0.76β1.20)</td><td>0.89 (0.68β1.17)</td><td>0.81 (0.59β1.14)</td><td>1.16 (0.91β1.47)</td><td>1.24 (0.93β1.66)</td><td>0.81 (0.60β1.12)</td><td>0.92 (0.64β1.32)</td></tr><tr><td>> 2 (hard)</td><td>2.4</td><td>1.08 (0.91β1.29)</td><td>1.04 (0.85β1.28)</td><td>0.93 (0.73β1.19)</td><td>0.90 (0.66β1.21)</td><td>0.99 (0.79β1.23)</td><td>0.93 (0.71β1.21)</td><td>0.84 (0.64β1.11)</td><td>0.86 (0.62β1.20)</td></tr><tr><td>p for trend</td><td></td><td>0.34</td><td>0.69</td><td>0.58</td><td>0.46</td><td>0.90</td><td>0.58</td><td>0.22</td><td>0.37</td></tr><tr><td colspan="10">Calcium concentration (mg/L)</td></tr><tr><td colspan="10">Quintiles</td></tr><tr><td>15β40</td><td>34.0</td><td>1.00 (reference)</td><td>1.00 (reference)</td><td>1.00 (reference)</td><td>1.00 (reference)</td><td>1.00 (reference)</td><td>1.00 (reference)</td><td>1.00 (reference)</td><td>1.00 (reference)</td></tr><tr><td>> 40β51</td><td>47.6</td><td>0.92 (0.74β1.14)</td><td>0.79 (0.59β1.06)</td><td>0.77 (0.57β1.06)</td><td>0.67 (0.44β1.03)</td><td>1.02 (0.78β1.34)</td><td>1.11 (0.77β1.61)</td><td>0.83 (0.59β1.16)</td><td>0.98 (0.62β1.55)</td></tr><tr><td>53β64</td><td>57.5</td><td>1.05 (0.81β1.38)</td><td>0.87 (0.59β1.27)</td><td>1.03 (0.71β1.51)</td><td>1.14 (0.67β1.97)</td><td>1.31 (0.94β1.82)</td><td>1.49 (0.91β2.43)</td><td>0.91 (0.60β1.41)</td><td>1.12 (0.61β2.07)</td></tr><tr><td>> 64β81</td><td>80.0</td><td>1.05 (0.85β1.29)</td><td>0.91 (0.65β1.28)</td><td>0.81 (0.60β1.10)</td><td>0.80 (0.49β1.31)</td><td>1.01 (0.77β1.32)</td><td>1.15 (0.73β1.80)</td><td>0.73 (0.52β1.03)</td><td>0.86 (0.48β1.52)</td></tr><tr><td>82β157</td><td>107.0</td><td>1.14 (0.87β1.47)</td><td>0.91 (0.60β1.38)</td><td>0.95 (0.65β1.38)</td><td>1.18 (0.62β2.22)</td><td>1.03 (0.74β1.43)</td><td>1.11 (0.59β2.07)</td><td>0.87 (0.57β1.31)</td><td>1.01 (0.47β2.19)</td></tr><tr><td>p for trend</td><td></td><td>0.19</td><td>0.88</td><td>0.69</td><td>0.66</td><td>0.85</td><td>0.75</td><td>0.22</td><td>0.71</td></tr><tr><td colspan="10">Magnesium concentration (mg/L)</td></tr><tr><td colspan="10">Quintiles</td></tr><tr><td>1.7β3.8</td><td>3.4</td><td>1.00 (reference)</td><td>1.00 (reference)</td><td>1.00 (reference)</td><td>1.00 (reference)</td><td>1.00 (reference)</td><td>1.00 (reference)</td><td>1.00 (reference)</td><td>1.00 (reference)</td></tr><tr><td>4.2β6.0</td><td>4.9</td><td>1.06 (0.84β1.34)</td><td>1.04 (0.76β1.42)</td><td>0.88 (0.64β1.23)</td><td>0.82 (0.53β1.29)</td><td>1.14 (0.85β1.53)</td><td>1.08 (0.73β1.58)</td><td>0.85 (0.58β1.24)</td><td>0.84 (0.52β1.35)</td></tr><tr><td>6.0β8.0</td><td>7.3</td><td>1.10 (0.87β1.39)</td><td>1.21 (0.87β1.71)</td><td>0.70 (0.50β1.00)</td><td>0.80 (0.48β1.33)</td><td>0.87 (0.64β1.17)</td><td>0.75 (0.49β1.18)</td><td>0.86 (0.59β1.23)</td><td>0.84 (0.49β1.43)</td></tr><tr><td>> 8.0β8.2</td><td>8.1</td><td>0.97 (0.78β1.22)</td><td>0.95 (0.67β1.33)</td><td>0.84 (0.62β1.16)</td><td>0.87 (0.53β1.44)</td><td>1.14 (0.86β1.52)</td><td>0.97 (0.62β1.53)</td><td>1.02 (0.72β1.44)</td><td>1.10 (0.62β1.96)</td></tr><tr><td>8.5β26.2</td><td>10.6</td><td>1.19 (0.93β1.53)</td><td>1.23 (0.82β1.86)</td><td>0.84 (0.59β1.20)</td><td>0.69 (0.37β1.31)</td><td>1.10 (0.81β1.50)</td><td>0.89 (0.50β1.59)</td><td>0.82 (0.55β1.23)</td><td>0.77 (0.38β1.57)</td></tr><tr><td>p for trend</td><td></td><td>0.43</td><td>0.71</td><td>0.29</td><td>0.44</td><td>0.55</td><td>0.66</td><td>0.70</td><td>0.97</td></tr></table>
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386aae8b0ca942e879975a030f948934022d46fc2c0ff77f83b045ef09b016ca.png
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simple
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<table><tr><td></td><td><i>n</i></td><td>Mean (SD) or %</td></tr><tr><td>Age</td><td>5052</td><td>46.0 (9.0)</td></tr><tr><td>Job seniority</td><td>4979</td><td>8.6 (7.1)</td></tr><tr><td>BMI</td><td></td><td></td></tr><tr><td> Normal</td><td>2842</td><td>58.8%</td></tr><tr><td> Overweight</td><td>1415</td><td>29.3%</td></tr><tr><td> Obese</td><td>577</td><td>11.9%</td></tr><tr><td>Smoking</td><td>1776</td><td>35.5%</td></tr><tr><td>Physical workloada</td><td>4917</td><td>19.4 (9.7)</td></tr><tr><td>Leisure physical activity</td><td></td><td></td></tr><tr><td> Sedentary</td><td>183</td><td>3.7%</td></tr><tr><td> Light physical activity</td><td>2039</td><td>41.0%</td></tr><tr><td> Moderate physical activity</td><td>2535</td><td>50.9%</td></tr><tr><td> Vigorous physical activity</td><td>220</td><td>4.4%</td></tr><tr><td>Psychosocial work environmentb</td><td></td><td></td></tr><tr><td> Emotional demands</td><td>5011</td><td>46.9 (17.9)</td></tr><tr><td> Influence at work</td><td>5010</td><td>45.6 (20.0)</td></tr><tr><td> Role clarity</td><td>5011</td><td>74.3 (14.2)</td></tr><tr><td> Leadership quality</td><td>4931</td><td>57.2 (21.5)</td></tr><tr><td>Low back pain</td><td></td><td></td></tr><tr><td> No pain</td><td>1558</td><td>31.2%</td></tr><tr><td> Subchronic pain</td><td>2327</td><td>46.6%</td></tr><tr><td> Chronic pain</td><td>1113</td><td>22.3%</td></tr><tr><td>Neck and shoulder pain</td><td></td><td></td></tr><tr><td> No pain</td><td>1470</td><td>29.4%</td></tr><tr><td> Subchronic pain</td><td>2113</td><td>42.2%</td></tr><tr><td> Chronic pain</td><td>1423</td><td>28.4%</td></tr><tr><td>Knee pain</td><td></td><td></td></tr><tr><td> No pain</td><td>3215</td><td>64.5%</td></tr><tr><td> Subchronic pain</td><td>1166</td><td>23.4%</td></tr><tr><td> Chronic pain</td><td>601</td><td>12.1%</td></tr></table>
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<table><tr><td></td><td>n</td><td>Mean (SD) or %</td></tr><tr><td>Age</td><td>5052</td><td>46.0 (9.0)</td></tr></table>
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<table><tr><td>Job seniority</td><td>4979</td><td>8.6 (7.1)</td></tr><tr><td>BMI</td><td></td><td></td></tr><tr><td>Normal</td><td>2842</td><td>58.8%</td></tr><tr><td>Overweight</td><td>1415</td><td>29.3%</td></tr><tr><td>Obese</td><td>577</td><td>11.9%</td></tr><tr><td>Smoking</td><td>1776</td><td>35.5%</td></tr><tr><td>Physical workloada</td><td>4917</td><td>19.4 (9.7)</td></tr><tr><td>Leisure physical activity</td><td></td><td></td></tr><tr><td>Sedentary</td><td>183</td><td>3.7%</td></tr><tr><td>Light physical activity</td><td>2039</td><td>41.0%</td></tr><tr><td>Moderate physical activity</td><td>2535</td><td>50.9%</td></tr><tr><td>Vigorous physical activity</td><td>220</td><td>4.4%</td></tr><tr><td>Psychosocial work environmentb</td><td></td><td></td></tr><tr><td>Emotional demands</td><td>5011</td><td>46.9 (17.9)</td></tr><tr><td>Influence at work</td><td>5010</td><td>45.6 (20.0)</td></tr><tr><td>Role clarity</td><td>5011</td><td>74.3 (14.2)</td></tr><tr><td>Leadership quality</td><td>4931</td><td>57.2 (21.5)</td></tr><tr><td>Low back pain</td><td></td><td></td></tr><tr><td>No pain</td><td>1558</td><td>31.2%</td></tr><tr><td>Subchronic pain</td><td>2327</td><td>46.6%</td></tr><tr><td>Chronic pain</td><td>1113</td><td>22.3%</td></tr><tr><td>Neck and shoulder pain</td><td></td><td></td></tr><tr><td>No pain</td><td>1470</td><td>29.4%</td></tr><tr><td>Subchronic pain</td><td>2113</td><td>42.2%</td></tr><tr><td>Chronic pain</td><td>1423</td><td>28.4%</td></tr><tr><td>Knee pain</td><td></td><td></td></tr><tr><td>No pain</td><td>3215</td><td>64.5%</td></tr><tr><td>Subchronic pain</td><td>1166</td><td>23.4%</td></tr><tr><td>Chronic pain</td><td>601</td><td>12.1%</td></tr></table>
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741a2452573d32e054af768c11c44b90e0e5d8f99d893dc6389c015a53afb7b5.png
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complex
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<table><tr><td colspan="4"> </td><td>Astrocytoma</td><td>Medulloblastoma</td><td>Craniopharyngioma</td><td>Germ cell tumors</td><td>Ependymal tumours</td></tr><tr><td>Country</td><td>Author</td><td>Period</td><td>Age(yrs)</td><td colspan="5"> </td></tr><tr><td>China</td><td> </td><td>1990-2009</td><td>0-19</td><td>29.2%</td><td>13.1%</td><td>12.3%</td><td>8.1%</td><td>6.2%</td></tr><tr><td>Taipei</td><td>Wong et al. [11]</td><td>1975-2004</td><td>0-18</td><td>36.9%</td><td>15.8%</td><td>9.8</td><td>12.7%</td><td>6.8%</td></tr><tr><td>Japan</td><td>Makino et al. [12]</td><td>1989-2008</td><td>0-15</td><td>38.6%</td><td>13.1%</td><td>13.7</td><td>14.4%</td><td>5.2%</td></tr><tr><td>India</td><td>Asirvatham et al. [8]</td><td>1990-2004</td><td>0-18</td><td>49.7%</td><td>12.0%</td><td>10.3%</td><td>3.0%</td><td>5.2%</td></tr><tr><td>France</td><td>Bauchet et al. [9]</td><td>2004-2006</td><td>0-19</td><td>32.9%</td><td>13.1%</td><td>5.4%</td><td>3.6%</td><td>8.6%</td></tr><tr><td>Brazil</td><td>Pinho et al. [10]</td><td>1989-2009</td><td>0-21</td><td>37.7%</td><td>16.3%</td><td>12.5%</td><td>7.0%</td><td>8.1%</td></tr><tr><td>US</td><td>CBTRUS [6]</td><td>2004-2007</td><td>0-19</td><td>33.1%</td><td>12.0%</td><td>3.6%</td><td>4.8%</td><td>6.7%</td></tr></table>
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<table><tr><td colspan="4"></td><td>Astrocytoma</td><td>Medulloblastoma</td><td>Craniopharyngioma</td><td>Germ cell tumors</td><td>Ependymal tumours</td></tr><tr><td>Country</td><td>Author</td><td>Period</td><td>Age(yrs)</td><td colspan="5"></td></tr><tr><td>China</td><td></td><td>1990-2009</td><td>0-19</td><td>29.2%</td><td>13.1%</td><td>12.3%</td><td>8.1%</td><td>6.2%</td></tr><tr><td>Taipei</td><td>Wong et al. [11]</td><td>1975-2004</td><td>0-18</td><td>36.9%</td><td>15.8%</td><td>9.8</td><td>12.7%</td><td>6.8%</td></tr><tr><td>Japan</td><td>Makino et al. [12]</td><td>1989-2008</td><td>0-15</td><td>38.6%</td><td>13.1%</td><td>13.7</td><td>14.4%</td><td>5.2%</td></tr></table>
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<table><tr><td>India</td><td>Asirvatham et al. [8]</td><td>1990-2004</td><td>0-18</td><td>49.7%</td><td>12.0%</td><td>10.3%</td><td>3.0%</td><td>5.2%</td></tr><tr><td>France</td><td>Bauchet et al. [9]</td><td>2004-2006</td><td>0-19</td><td>32.9%</td><td>13.1%</td><td>5.4%</td><td>3.6%</td><td>8.6%</td></tr><tr><td>Brazil</td><td>Pinho et al. [10]</td><td>1989-2009</td><td>0-21</td><td>37.7%</td><td>16.3%</td><td>12.5%</td><td>7.0%</td><td>8.1%</td></tr><tr><td>US</td><td>CBTRUS [6]</td><td>2004-2007</td><td>0-19</td><td>33.1%</td><td>12.0%</td><td>3.6%</td><td>4.8%</td><td>6.7%</td></tr></table>
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9adc8fe99bef9703d87a66b7c9341f500489640d155272da8913e664b34d8d35.png
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complex
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<table><tr><td></td><td>Tiotropium</td><td>Control</td><td>Hazard ratio(tiotropium versus control)*(95% CI)</td></tr><tr><td colspan="4">Time to first exacerbation, median month</td></tr><tr><td>Q1</td><td>19.4</td><td>14.6</td><td>0.80 (0.70 to 0.92)</td></tr><tr><td>Q2</td><td>22.4</td><td>13.6</td><td>0.83 (0.73 to 0.94)</td></tr><tr><td>Q3</td><td>16.6</td><td>16.3</td><td>0.97 (0.86 to 1.11)</td></tr><tr><td>Q4</td><td>14.9</td><td>12.7</td><td>0.88 (0.78 to 1.01)</td></tr><tr><td colspan="4">Time to first exacerbation leading to hospitalization (first quartile), month</td></tr><tr><td>Q1</td><td>NA</td><td>39.9</td><td>0.72 (0.57 to 0.91)</td></tr><tr><td>Q2</td><td>47.2</td><td>32.5</td><td>0.73 (0.59 to 0.90)</td></tr><tr><td>Q3</td><td>37.0</td><td>40.2</td><td>1.05 (0.86 to 1.30)</td></tr><tr><td>Q4</td><td>28.5</td><td>26.0</td><td>0.98 (0.81 to 1.18)</td></tr></table>
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<table><tr><td></td><td>Tiotropium</td><td>Control</td><td>Hazard ratio(tiotropium versus control)*(95% CI)</td></tr><tr><td colspan="4">Time to first exacerbation, median month</td></tr><tr><td>Q1</td><td>19.4</td><td>14.6</td><td>0.80 (0.70 to 0.92)</td></tr><tr><td>Q2</td><td>22.4</td><td>13.6</td><td>0.83 (0.73 to 0.94)</td></tr><tr><td>Q3</td><td>16.6</td><td>16.3</td><td>0.97 (0.86 to 1.11)</td></tr><tr><td>Q4</td><td>14.9</td><td>12.7</td><td>0.88 (0.78 to 1.01)</td></tr><tr><td colspan="4">Time t</td></tr></table>
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<table><tr><td colspan="4">o first exacerbation leading to hospitalization (first quartile), month</td></tr><tr><td>Q1</td><td>NA</td><td>39.9</td><td>0.72 (0.57 to 0.91)</td></tr><tr><td>Q2</td><td>47.2</td><td>32.5</td><td>0.73 (0.59 to 0.90)</td></tr><tr><td>Q3</td><td>37.0</td><td>40.2</td><td>1.05 (0.86 to 1.30)</td></tr><tr><td>Q4</td><td>28.5</td><td>26.0</td><td>0.98 (0.81 to 1.18)</td></tr></table>
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19d864d3f194e059d0556a35301f79dd377cf010faaa56e1fc8788105f7777c0.png
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simple
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<table><tr><td>Node name</td><td>Links</td><td>Links in background</td><td>Links to seed</td><td>Links in subnetwork</td><td><i>z</i>-score</td></tr><tr><td>FUT4</td><td>3</td><td>11429</td><td>2</td><td>29</td><td>22.86</td></tr><tr><td>ICAM5</td><td>4</td><td>11429</td><td>2</td><td>29</td><td>19.77</td></tr><tr><td>PRTN3</td><td>9</td><td>11429</td><td>2</td><td>29</td><td>13.10</td></tr><tr><td>IL2RA</td><td>22</td><td>11429</td><td>3</td><td>29</td><td>12.47</td></tr><tr><td>ICAM3</td><td>10</td><td>11429</td><td>2</td><td>29</td><td>12.41</td></tr><tr><td>VIL2</td><td>32</td><td>11429</td><td>3</td><td>29</td><td>10.25</td></tr><tr><td>ITGAM</td><td>15</td><td>11429</td><td>2</td><td>29</td><td>10.06</td></tr><tr><td>EZR</td><td>34</td><td>11429</td><td>3</td><td>29</td><td>9.93</td></tr><tr><td>KNG1</td><td>22</td><td>11429</td><td>2</td><td>29</td><td>8.23</td></tr><tr><td>RANBP9</td><td>22</td><td>11429</td><td>2</td><td>29</td><td>8.23</td></tr><tr><td>A2M</td><td>24</td><td>11429</td><td>2</td><td>29</td><td>7.86</td></tr><tr><td>PTPRC</td><td>35</td><td>11429</td><td>2</td><td>29</td><td>6.42</td></tr><tr><td>GRB2</td><td>196</td><td>11429</td><td>2</td><td>29</td><td>2.13</td></tr></table>
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<table><tr><td>Node name</td><td>Links</td><td>Links in background</td><td>Links to seed</td><td>Links in subnetwork</td></tr><tr><td>FUT4</td><td>3</td><td>11429</td><td>2</td><td>29</td></tr><tr><td>ICAM5</td><td>4</td><td>11429</td><td>2</td><td>29</td></tr><tr><td>PRTN3</td><td>9</td><td>11429</td><td>2</td><td>29</td></tr><tr><td>IL2RA</td><td>22</td><td>11429</td><td>3</td><td>29</td></tr><tr><td>ICAM3</td><td>10</td><td>11429</td><td>2</td><td>29</td></tr><tr><td>VIL2</td><td>32</td><td>11429</td><td>3</td><td>29</td></tr><tr><td>ITGAM</td><td>15</td><td>11429</td><td>2</td><td>29</td></tr><tr><td>EZR</td><td>34</td><td>11429</td><td>3</td><td>29</td></tr><tr><td>KNG1</td><td>22</td><td>11429</td><td>2</td><td>29</td></tr><tr><td>RANBP9</td><td>22</td><td>11429</td><td>2</td><td>29</td></tr><tr><td>A2M</td><td>24</td><td>11429</td><td>2</td><td>29</td></tr><tr><td>PTPRC</td><td>35</td><td>11429</td><td>2</td><td>29</td></tr><tr><td>GRB2</td><td>196</td><td>11429</td><td>2</td><td>29</td></tr></table>
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<table><tr><td>z-score</td></tr><tr><td>22.86</td></tr><tr><td>19.77</td></tr><tr><td>13.10</td></tr><tr><td>12.47</td></tr><tr><td>12.41</td></tr><tr><td>10.25</td></tr><tr><td>10.06</td></tr><tr><td>9.93</td></tr><tr><td>8.23</td></tr><tr><td>8.23</td></tr><tr><td>7.86</td></tr><tr><td>6.42</td></tr><tr><td>2.13</td></tr></table>
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ff6136a38cf0d0e9c85135b4bb6e8bd9511ee20d1adf035299b47bfa5fdaab29.png
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complex
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<table><tr><td colspan="3">Simulated Data</td><td colspan="3">Mediated SEM</td><td colspan="3">Mixed Model without Mediator</td></tr><tr><td>Effect Size</td><td>Effect Distribution</td><td>Effect</td><td>Bias (%)</td><td>Coverage Probability (%)</td><td>Power (%)</td><td>Bias (%)</td><td>Coverage Probability (%)</td><td>Power (%)</td></tr><tr><td>Large</td><td>Equal</td><td>Total</td><td>-0.8</td><td>94</td><td>100</td><td>-0.8</td><td>94</td><td>100</td></tr><tr><td></td><td>Direct</td><td>Total</td><td>-0.8</td><td>94</td><td>100</td><td>-0.8</td><td>93</td><td>100</td></tr><tr><td></td><td>Indirect</td><td>Total</td><td>0.9</td><td>94</td><td>100</td><td>-0.6</td><td>94</td><td>100</td></tr><tr><td>Medium</td><td>Equal</td><td>Total</td><td>-1.5</td><td>94</td><td>95</td><td>-1.5</td><td>93</td><td>94</td></tr><tr><td></td><td>Direct</td><td>Total</td><td>-1.5</td><td>94</td><td>97</td><td>-1.5</td><td>93</td><td>96</td></tr><tr><td></td><td>Indirect</td><td>Total</td><td>-1.3</td><td>94</td><td>93</td><td>-1.3</td><td>93</td><td>92</td></tr><tr><td>Medium-Small</td><td>Equal</td><td>Total</td><td>-2.0</td><td>94</td><td>80</td><td>-2.0</td><td>93</td><td>80</td></tr><tr><td></td><td>Direct</td><td>Total</td><td>-0.9</td><td>94</td><td>84</td><td>-0.9</td><td>93</td><td>83</td></tr><tr><td></td><td>Indirect</td><td>Total</td><td>-1.8</td><td>94</td><td>80</td><td>-1.8</td><td>93</td><td>79</td></tr><tr><td>Small</td><td>Equal</td><td>Total</td><td>-3.7</td><td>94</td><td>32</td><td>-3.7</td><td>93</td><td>32</td></tr><tr><td></td><td>Direct</td><td>Total</td><td>-3.9</td><td>94</td><td>36</td><td>-4.0</td><td>93</td><td>35</td></tr><tr><td></td><td>Indirect</td><td>Total</td><td>-3.7</td><td>94</td><td>34</td><td>-3.7</td><td>93</td><td>33</td></tr></table>
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<table><tr><td colspan="3">Simulated Data</td><td colspan="3">Mediated SEM</td><td colspan="3">Mixed Model without Mediator</td></tr><tr><td>Effect Size</td><td>Effect Distribution</td><td>Effect</td><td>Bias (%)</td><td>Coverage Probability (%)</td><td>Power (%)</td><td>Bias (%)</td><td>Coverage Probability (%)</td><td>Power (%)</td></tr><tr><td>Large</td><td>Equal</td><td>Total</td><td>-0.8</td><td>94</td><td>100</td><td>-0.8</td><td>94</td><td>100</td></tr><tr><td></td><td>Direct</td><td>Total</td><td>-0.8</td><td>94</td><td>100</td><td>-0.8</td><td>93</td><td>100</td></tr></table>
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<table><tr><td colspan="3">Simulated Data</td><td colspan="3">Mediated SEM</td><td colspan="3">Mixed Model without Mediator</td></tr><tr><td></td><td>Indirect</td><td>Total</td><td>0.9</td><td>94</td><td>100</td><td>-0.6</td><td>94</td><td>100</td></tr><tr><td>Medium</td><td>Equal</td><td>Total</td><td>-1.5</td><td>94</td><td>95</td><td>-1.5</td><td>93</td><td>94</td></tr><tr><td></td><td>Direct</td><td>Total</td><td>-1.5</td><td>94</td><td>97</td><td>-1.5</td><td>93</td><td>96</td></tr><tr><td></td><td>Indirect</td><td>Total</td><td>-1.3</td><td>94</td><td>93</td><td>-1.3</td><td>93</td><td>92</td></tr><tr><td>Medium-Small</td><td>Equal</td><td>Total</td><td>-2.0</td><td>94</td><td>80</td><td>-2.0</td><td>93</td><td>80</td></tr><tr><td></td><td>Direct</td><td>Total</td><td>-0.9</td><td>94</td><td>84</td><td>-0.9</td><td>93</td><td>83</td></tr><tr><td></td><td>Indirect</td><td>Total</td><td>-1.8</td><td>94</td><td>80</td><td>-1.8</td><td>93</td><td>79</td></tr><tr><td>Small</td><td>Equal</td><td>Total</td><td>-3.7</td><td>94</td><td>32</td><td>-3.7</td><td>93</td><td>32</td></tr><tr><td></td><td>Direct</td><td>Total</td><td>-3.9</td><td>94</td><td>36</td><td>-4.0</td><td>93</td><td>35</td></tr><tr><td></td><td>Indirect</td><td>Total</td><td>-3.7</td><td>94</td><td>34</td><td>-3.7</td><td>93</td><td>33</td></tr></table>
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538a583877c54c54b73f21ba9c65a3a2286c9f2a0ec35367254e92b0875b6ead.png
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simple
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<table><tr><td>Clinical parameter</td><td>Vehicle</td><td>SMI 6877002</td><td>Statistics</td></tr><tr><td>Incidence (%)</td><td>100</td><td>100</td><td></td></tr><tr><td>Survival (%)</td><td>100</td><td>100</td><td></td></tr><tr><td>AUC</td><td>10.6</td><td>8.7</td><td><i>P</i> = 0.0804</td></tr><tr><td>Mean clinical score (day 13)</td><td>2.9</td><td>2.0</td><td><i>P</i> = 0.1160</td></tr><tr><td>Mean day of onset</td><td>11.1</td><td>11.5</td><td><i>P</i> = 0.4740</td></tr><tr><td>Mean peak disease severity</td><td>3.4</td><td>2.9</td><td><i>P</i> = 0.0184</td></tr><tr><td>% Body weight loss (day 12 compared to day 0)</td><td>5.4</td><td>4.7</td><td><i>P</i> = 0.2636</td></tr></table>
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<table><tr><td>Clinical parameter</td><td>Vehicle</td><td>SMI 6877002</td><td>Statistics</td></tr><tr><td>Incidence (%)</td><td>100</td><td>100</td><td></td></tr><tr><td>Survival (%)</td><td>100</td><td>100</td><td></td></tr></table>
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<table><tr><td>Clinical parameter</td><td>Vehicle</td><td>SMI 6877002</td><td>Statistics</td></tr><tr><td>AUC</td><td>10.6</td><td>8.7</td><td>P = 0.0804</td></tr><tr><td>Mean clinical score (day 13)</td><td>2.9</td><td>2.0</td><td>P = 0.1160</td></tr><tr><td>Mean day of onset</td><td>11.1</td><td>11.5</td><td>P = 0.4740</td></tr><tr><td>Mean peak disease severity</td><td>3.4</td><td>2.9</td><td>P = 0.0184</td></tr><tr><td>% Body weight loss (day 12 compared to day 0)</td><td>5.4</td><td>4.7</td><td>P = 0.2636</td></tr></table>
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db98073afb7f28494ac0e673502bb222e3c7e88dd0d0532a44b9d75596f6877d.png
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complex
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<table><tr><td rowspan="2">Industry (type of animal)</td><td colspan="2">No. (%)</td></tr><tr><td>Campylobacteriosis</td><td>Cryptosporidiosis</td></tr><tr><td>Total</td><td>557 (100.0)</td><td>93 (100.0)</td></tr><tr><td>Animal production</td><td>380 (68.2)</td><td>73 (78.5)</td></tr><tr><td>(Cattle and other bovines)</td><td>271 (71.3)</td><td>63 (86.3)</td></tr><tr><td>(Chicken and other poultry)</td><td>35 (9.2)</td><td>0 (—)</td></tr><tr><td>(Swine)</td><td>21 (5.5)</td><td>0 (—)</td></tr><tr><td>(Other/Multiple farm animals)</td><td>53 (14.0)</td><td>10 (13.7)</td></tr><tr><td>Animal slaughtering and processing</td><td>91 (16.3)</td><td>5 (5.4)</td></tr><tr><td>(Beef cattle processing)</td><td>52 (57.1)</td><td>2 (40.0)</td></tr><tr><td>(Poultry processing)</td><td>13 (14.3)</td><td>0 (—)</td></tr><tr><td>(Swine processing)</td><td>10 (11.0)</td><td>2 (40.0)</td></tr><tr><td>(Multiple animals/Unspecified)</td><td>16 (17.6)</td><td>1 (20.0)</td></tr><tr><td>Veterinary services</td><td>24 (4.3)</td><td>7 (7.5)</td></tr><tr><td>Other (shelter, rescue, pet store)</td><td>62 (11.1)</td><td>8 (8.6)</td></tr></table>
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<table><tr><td rowspan="2">Industry (type of animal)</td><td colspan="2">No. (%)</td></tr><tr><td>Campylobacteriosis</td><td>Cryptosporidiosis</td></tr><tr><td>Total</td><td>557 (100.0)</td><td>93 (100.0)</td></tr><tr><td>Animal production</td><td>380 (68.2)</td><td>73 (78.5)</td></tr><tr><td>(Cattle and other bovines)</td><td>271 (71.3)</td><td>63 (86.3)</td></tr><tr><td>(Chicken and other poultry)</td><td>35 (9.2)</td><td>0 (β)</td></tr><tr><td>(Swine)</td><td>21 (5.5)</td><td>0 (β)</td></tr><tr><td>(Other/Multiple farm animals)</td><td>53 (14.0)</td><td>10 (13.7)</td></tr><tr><td>Animal slaughtering and processing</td><td>91 (16.3)</td><td>5 (5.4)</td></tr></table>
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<table><tr><td>(Beef cattle processing)</td><td>52 (57.1)</td><td>2 (40.0)</td></tr><tr><td>(Poultry processing)</td><td>13 (14.3)</td><td>0 (β)</td></tr><tr><td>(Swine processing)</td><td>10 (11.0)</td><td>2 (40.0)</td></tr><tr><td>(Multiple animals/Unspecified)</td><td>16 (17.6)</td><td>1 (20.0)</td></tr><tr><td>Veterinary services</td><td>24 (4.3)</td><td>7 (7.5)</td></tr><tr><td>Other (shelter, rescue, pet store)</td><td>62 (11.1)</td><td>8 (8.6)</td></tr></table>
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