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f6932a61a9eb2bb3827729e1a37c40f56b48f49a53ba40f6b651872648b9e215.png
simple
<table><tr><td>Subject</td><td>Age enrollment(years)</td><td>GMFCS level at enrollment</td><td>GMFM-66 change over 2 years</td><td>Abnormalmovements</td><td>Typography</td></tr><tr><td>1</td><td>1.7</td><td>IV</td><td>4</td><td>Spasticity with dystonia</td><td>Q</td></tr><tr><td>2</td><td>2.4</td><td>II</td><td>8</td><td>Spasticity</td><td>D</td></tr><tr><td>3</td><td>5.1</td><td>I</td><td>19</td><td>Spasticity with dystonia</td><td>H (Lh)</td></tr><tr><td>4</td><td>1.2</td><td>IV</td><td>4</td><td>Spasticity with dystonia</td><td>Q</td></tr><tr><td>5</td><td>4.0</td><td>II</td><td>2</td><td>Spasticity with dystonia</td><td>H (Lh)</td></tr><tr><td>6</td><td>4.4</td><td>III</td><td>4</td><td>Spasticity</td><td>D</td></tr><tr><td>7</td><td>2.3</td><td>II</td><td>11</td><td>Spasticity</td><td>H (Rh)</td></tr><tr><td>8</td><td>1.4</td><td>II</td><td>17</td><td>Spasticity</td><td>H (Lh)</td></tr><tr><td>9</td><td>1.1</td><td>I</td><td>16</td><td>Spasticity with dystonia</td><td>H (Rh)</td></tr><tr><td>10</td><td>3.7</td><td>II</td><td>11</td><td>Spasticity</td><td>H (Rh)</td></tr><tr><td>11</td><td>1.5</td><td>IV</td><td>2</td><td>Spasticity with dystonia</td><td>Q</td></tr><tr><td>12</td><td>3.8</td><td>IV</td><td>5</td><td>Spasticity with dystonia</td><td>Q</td></tr><tr><td>13</td><td>2.1</td><td>II</td><td>15</td><td>Spasticity</td><td>D</td></tr><tr><td>14</td><td>2.8</td><td>II</td><td>13</td><td>Spasticity with dystonia</td><td>H (Lh)</td></tr><tr><td>15</td><td>2.8</td><td>II</td><td>5</td><td>Spasticity</td><td>D</td></tr><tr><td>16</td><td>1.4</td><td>IV</td><td>6</td><td>Spasticity predominant, mixed with dystonia</td><td>Q</td></tr><tr><td>17</td><td>3.0</td><td>III</td><td>22</td><td>Spasticity predominant, mixed with spasticity</td><td>T (LUE)</td></tr></table>
<table><tr><td>Subject</td><td>Age enrollment(years)</td><td>GMFCS level at enrollment</td><td>GMFM-66 change over 2 years</td><td>Abnormalmovements</td><td>Typography</td></tr><tr><td>1</td><td>1.7</td><td>IV</td><td>4</td><td>Spasticity with dystonia</td><td>Q</td></tr><tr><td>2</td><td>2.4</td><td>II</td><td>8</td><td>Spasticity</td><td>D</td></tr><tr><td>3</td><td>5.1</td><td>I</td><td>19</td><td>Spasticity with dystonia</td><td>H (Lh)</td></tr><tr><td>4</td><td>1.2</td><td>IV</td><td>4</td><td>Spasticity with dystonia</td><td>Q</td></tr><tr><td>5</td><td>4.0</td><td>II</td><td>2</td><td>Spasticity with dystonia</td><td>H (Lh)</td></tr><tr><td>6</td><td>4.4</td><td>III</td><td>4</td><td>Spasticity</td><td>D</td></tr><tr><td>7</td><td>2.3</td><td>II</td><td>11</td><td>Spasticity</td><td>H (Rh)</td></tr><tr><td>8</td><td>1.4</td><td>II</td><td>17</td><td>Spasticity</td><td>H (Lh)</td></tr><tr><td>9</td><td>1.1</td><td>I</td><td>16</td><td>Spasticity with dystonia</td><td>H (Rh)</td></tr><tr><td>10</td><td>3.7</td><td>II</td><td>11</td><td>Spasticity</td><td>H (Rh)</td></tr><tr><td>11</td><td>1.5</td><td>IV</td><td>2</td><td>Spasticity with dystonia</td><td>Q</td></tr><tr><td>12</td><td>3.8</td><td>IV</td><td>5</td><td>Spasticity with dystonia</td><td>Q</td></tr><tr><td>13</td><td>2.1</td><td>II</td><td>15</td><td>Spasticity</td><td>D</td></tr><tr><td>14</td><td>2.8</td><td>II</td><td>13</td><td>Spasticity with dystonia</td><td>H (Lh)</td></tr><tr><td>15</td><td></td><td>I</td><td></td><td></td><td></td></tr></table>
<table><tr><td>Subject</td><td>Age enrollment(years)</td><td>GMFCS level at enrollment</td><td>GMFM-66 change over 2 years</td><td>Abnormalmovements</td><td>Typography</td></tr><tr><td></td><td>2.8</td><td>I</td><td>5</td><td>Spasticity</td><td>D</td></tr><tr><td>16</td><td>1.4</td><td>IV</td><td>6</td><td>Spasticity predominant, mixed with dystonia</td><td>Q</td></tr><tr><td>17</td><td>3.0</td><td>III</td><td>22</td><td>Spasticity predominant, mixed with spasticity</td><td>T (LUE)</td></tr></table>
4a68a79ca884e97e0145ac007ade81d0ac82f4826916408115d006f6e7ae75f6.png
complex
<table><tr><td>Compound</td><td>Class</td><td>PIM inhibition selectivity</td><td>Development</td><td>Disease</td></tr><tr><td>SGI-1776</td><td>imadizaopyridazine</td><td>IC50: 7 nM PIM1, 363 nM PIM2, 69 nM PIM3, 44 nM FLT-3 and 34 nM Haspin [107].</td><td>Failure in phase I clinical trials by cardiotoxicity</td><td>Non-Hodgkin lymphoma</td></tr><tr><td rowspan="2">SMI4a</td><td rowspan="2">benzylidene-thiazolidene-2,4-dione</td><td>IC50: 21 nM PIM1, 100 nM PIM2 [113].</td><td rowspan="2">Preclinical</td><td rowspan="2">Acute myeloid leukemia</td></tr><tr><td>Selective vs. 56 kinases [114].</td></tr><tr><td>LGB321</td><td>3-(S)-amino-piperidine pyridyl carboxamide</td><td>IC50: 0.001 nM PIM1, 0.0021 nM PIM2, and 0.0008 nM PIM3 [106].</td><td>Recruiting patients for clinical trials</td><td>Multiple myeloma</td></tr><tr><td>AZD1897</td><td></td><td>IC50: 3 nM PIM1,2 and 3 [115].</td><td>Preclinical</td><td>Acute myeloid leukemia</td></tr><tr><td>SEL24-B58</td><td>Benzoimidazol</td><td>IC50: 31 nM PIM1, 154 nM PIM2, 152 nM PIM3. Selective in a panel of 299 kinases with the exception of haspin, HIPK and CLK kinases [117].</td><td>Preclinical</td><td>Leukemic monocyte lymphoma</td></tr><tr><td>AZD1208</td><td>thiazolidene</td><td>IC50: Pim-1 0.4 nM, Pim-2 5.0 nM and Pim-3 1.9 nM [115].</td><td>Recruiting patients for clinical trials</td><td>Acute myeloid leukemia</td></tr></table>
<table><tr><td>Compound</td><td>Class</td><td>PIM inhibition selectivity</td><td>Development</td><td>Disease</td></tr><tr><td></td><td>imadizaopyridazine</td><td>IC5</td><td>Failure in phase I clinical trials by cardiotoxicity</td><td>Non-Hodgkin lymph</td></tr></table>
<table><tr><td>SGI-1776</td><td></td><td>0: 7 nM PIM1, 363 nM PIM2, 69 nM PIM3, 44 nM FLT-3 and 34 nM Haspin [107].</td><td></td><td>oma</td></tr><tr><td rowspan="2">SMI4a</td><td rowspan="2">benzylidene-thiazolidene-2,4-dione</td><td>IC50: 21 nM PIM1, 100 nM PIM2 [113].</td><td rowspan="2">Preclinical</td><td rowspan="2">Acute myeloid leukemia</td></tr><tr><td>Selective vs. 56 kinases [114].</td></tr><tr><td>LGB321</td><td>3-(S)-amino-piperidine pyridyl carboxamide</td><td>IC50: 0.001 nM PIM1, 0.0021 nM PIM2, and 0.0008 nM PIM3 [106].</td><td>Recruiting patients for clinical trials</td><td>Multiple myeloma</td></tr><tr><td>AZD1897</td><td></td><td>IC50: 3 nM PIM1,2 and 3 [115].</td><td>Preclinical</td><td>Acute myeloid leukemia</td></tr><tr><td>SEL24-B58</td><td>Benzoimidazol</td><td>IC50: 31 nM PIM1, 154 nM PIM2, 152 nM PIM3. Selective in a panel of 299 kinases with the exception of haspin, HIPK and CLK kinases [117].</td><td>Preclinical</td><td>Leukemic monocyte lymphoma</td></tr><tr><td>AZD1208</td><td>thiazolidene</td><td>IC50: Pim-1 0.4 nM, Pim-2 5.0 nM and Pim-3 1.9 nM [115].</td><td>Recruiting patients for clinical trials</td><td>Acute myeloid leukemia</td></tr></table>
45bfab0c6797de9df93cdb7f6a305144030852fc9c257052e5ebcbe560c4f36f.png
simple
<table><tr><td>Upper Asymptote</td><td>Lower Asymptote</td><td>Sig Diff</td><td>Point of Inflection</td><td>Slope</td><td>Fit</td></tr><tr><td>0.99</td><td>0.48</td><td>&lt; 0.05</td><td>3.36</td><td>&#8722;1.75</td><td>0.15</td></tr></table>
<table><tr><td>Upper Asymptote</td><td>Lower Asymptote</td><td>Sig Diff</td><td>Point of Inflection</td><td>Slope</td><td>Fit</td></tr></table>
<table><tr><td>0.99</td><td>0.48</td><td>< 0.05</td><td>3.36</td><td>−1.75</td><td>0.15</td></tr></table>
79ba4391658af54caff5da965aef829cbdfae8ec9082370a7fc60e0a9d2b1260.png
simple
<table><tr><td>Age stratum</td><td>(%)</td></tr><tr><td> 39 years or younger</td><td>41</td></tr><tr><td> 40&#8211;49 years</td><td>42</td></tr><tr><td> 50 years or older</td><td>15</td></tr><tr><td> Missing data</td><td>2</td></tr><tr><td>Sex</td><td></td></tr><tr><td> Female</td><td>15</td></tr><tr><td> male</td><td>85</td></tr><tr><td>Fields of practice</td><td></td></tr><tr><td> Pediatrics</td><td>2</td></tr><tr><td> Family practice</td><td>11</td></tr><tr><td> General internal medicine</td><td>44</td></tr><tr><td> Specialty internal medicine</td><td>21</td></tr><tr><td> Surgery-related</td><td>7</td></tr><tr><td> Emergency medicine</td><td>9</td></tr><tr><td> The other fields</td><td>7</td></tr><tr><td>Size of employing facilities</td><td></td></tr><tr><td> Office-based clinic</td><td>24</td></tr><tr><td> 1&#8211;100 beds</td><td>13</td></tr><tr><td> 101&#8211;250 beds</td><td>17</td></tr><tr><td> 251&#8211;500 beds</td><td>17</td></tr><tr><td> 501 or more beds</td><td>28</td></tr></table>
<table><tr><td>Age stratum</td><td>(%)</td></tr></table>
<table><tr><td>39 years or younger</td><td>41</td></tr><tr><td>40–49 years</td><td>42</td></tr><tr><td>50 years or older</td><td>15</td></tr><tr><td>Missing data</td><td>2</td></tr><tr><td>Sex</td><td></td></tr><tr><td>Female</td><td>15</td></tr><tr><td>male</td><td>85</td></tr><tr><td>Fields of practice</td><td></td></tr><tr><td>Pediatrics</td><td>2</td></tr><tr><td>Family practice</td><td>11</td></tr><tr><td>General internal medicine</td><td>44</td></tr><tr><td>Specialty internal medicine</td><td>21</td></tr><tr><td>Surgery-related</td><td>7</td></tr><tr><td>Emergency medicine</td><td>9</td></tr><tr><td>The other fields</td><td>7</td></tr><tr><td>Size of employing facilities</td><td></td></tr><tr><td>Office-based clinic</td><td>24</td></tr><tr><td>1–100 beds</td><td>13</td></tr><tr><td>101–250 beds</td><td>17</td></tr><tr><td>251–500 beds</td><td>17</td></tr><tr><td>501 or more beds</td><td>28</td></tr></table>
4f8f531c60af67927a5f4b746a1ea2e3e24d461d1a684359f2d193f06b44a58e.png
complex
<table><tr><td rowspan="2">Characteristics</td><td rowspan="2">PTCL-NOS</td><td rowspan="2">NKT</td><td rowspan="2">AITL</td><td colspan="2">ALCL</td><td rowspan="2">Total</td></tr><tr><td>ALK+</td><td>ALK&#8722;</td></tr><tr><td>Age &gt; 60</td><td>20/60 (33.3)</td><td>2/18 (11.1)</td><td>6/11 (54.5)</td><td>0/4 (0.0)</td><td>1/4 (25.0)</td><td>29/109 (26.6)</td></tr><tr><td>Gender, male</td><td>38/60 (63.3)</td><td>13/18 (72.2)</td><td>9/11 (81.8)</td><td>3/4 (75.0)</td><td>3/4 (75.0)</td><td>75/109 (68.8)</td></tr><tr><td>B symptoms</td><td>47/58 (81.0)</td><td>16/18 (88.9)</td><td>11/11 (100.0)</td><td>4/4 (100.0)</td><td>2/4 (50.0)</td><td>90/107 (84.1)</td></tr><tr><td>LDH &gt; normal</td><td>36/58 (62.1)</td><td>10/17 (58.8)</td><td>10/11 (90.9)</td><td>4/4 (100.0)</td><td>2/4 (50.0)</td><td>68/105 (64.8)</td></tr><tr><td>Ann Arbor stage III/IV</td><td>52/58 (89.7)</td><td>15/16 (93.8)</td><td>11/11 (100.0)</td><td>4/4 (100.0)</td><td>3/4 (75.0)</td><td>80/109 (73.4)</td></tr><tr><td>ECOG &gt; 1</td><td>30/58 (51.7)</td><td>4/17 (23.5)</td><td>5/11 (45.5)</td><td>3/4 (75.0)</td><td>1/4 (25.0)</td><td>50/106 (47.2)</td></tr><tr><td>&gt; 1 extranodal site</td><td>29/57 (50.9)</td><td>11/17 (64.7)</td><td>4/11 (36.4)</td><td>4/4 (100.0)</td><td>2/4 (50.0)</td><td>57/104 (54.8)</td></tr><tr><td>BM involvement</td><td>16/55 (29.1)</td><td>3/17 (17.6)</td><td>1/11 (9.1)</td><td>1/4 (25.0)</td><td>1/4 (25.0)</td><td>25/101 (24.8)</td></tr><tr><td>IPI &gt; 2</td><td>35/57 (61.4)</td><td>10/18 (55.6)</td><td>7/11 (63.6)</td><td>4/4 (100.0)</td><td>3/4 (75.0)</td><td>65/105 (61.9)</td></tr><tr><td>Treatment with CHOP</td><td>26/60 (43.3)</td><td>3/18 (16.7)</td><td>5/11 (45.5)</td><td>3/4 (75.0)</td><td>1/4 (25.0)</td><td>42/109 (38.5)</td></tr></table>
<table><tr><td rowspan="2">Characteristics</td><td rowspan="2">PTCL-NOS</td><td rowspan="2">NKT</td><td rowspan="2">AITL</td><td colspan="2">ALCL</td><td rowspan="2">Total</td></tr><tr><td>ALK+</td><td>ALK−</td></tr><tr><td>Age > </td><td>2</td><td>2/18 (1</td><td>6/11 (54.5</td><td>0/4 (0.0)</td><td></td><td>29/109 (26.6)</td></tr></table>
<table><tr><td>60</td><td>0/60 (33.3)</td><td>1.1)</td><td>)</td><td></td><td>1/4 (25.0)</td><td></td></tr><tr><td>Gender, male</td><td>38/60 (63.3)</td><td>13/18 (72.2)</td><td>9/11 (81.8)</td><td>3/4 (75.0)</td><td>3/4 (75.0)</td><td>75/109 (68.8)</td></tr><tr><td>B symptoms</td><td>47/58 (81.0)</td><td>16/18 (88.9)</td><td>11/11 (100.0)</td><td>4/4 (100.0)</td><td>2/4 (50.0)</td><td>90/107 (84.1)</td></tr><tr><td>LDH > normal</td><td>36/58 (62.1)</td><td>10/17 (58.8)</td><td>10/11 (90.9)</td><td>4/4 (100.0)</td><td>2/4 (50.0)</td><td>68/105 (64.8)</td></tr><tr><td>Ann Arbor stage III/IV</td><td>52/58 (89.7)</td><td>15/16 (93.8)</td><td>11/11 (100.0)</td><td>4/4 (100.0)</td><td>3/4 (75.0)</td><td>80/109 (73.4)</td></tr><tr><td>ECOG > 1</td><td>30/58 (51.7)</td><td>4/17 (23.5)</td><td>5/11 (45.5)</td><td>3/4 (75.0)</td><td>1/4 (25.0)</td><td>50/106 (47.2)</td></tr><tr><td>> 1 extranodal site</td><td>29/57 (50.9)</td><td>11/17 (64.7)</td><td>4/11 (36.4)</td><td>4/4 (100.0)</td><td>2/4 (50.0)</td><td>57/104 (54.8)</td></tr><tr><td>BM involvement</td><td>16/55 (29.1)</td><td>3/17 (17.6)</td><td>1/11 (9.1)</td><td>1/4 (25.0)</td><td>1/4 (25.0)</td><td>25/101 (24.8)</td></tr><tr><td>IPI > 2</td><td>35/57 (61.4)</td><td>10/18 (55.6)</td><td>7/11 (63.6)</td><td>4/4 (100.0)</td><td>3/4 (75.0)</td><td>65/105 (61.9)</td></tr><tr><td>Treatment with CHOP</td><td>26/60 (43.3)</td><td>3/18 (16.7)</td><td>5/11 (45.5)</td><td>3/4 (75.0)</td><td>1/4 (25.0)</td><td>42/109 (38.5)</td></tr></table>
225fb17c2e2469bbfddd23ebb56f7717adedb85d1d001ca2e64cdb0c4d9c1b2a.png
complex
<table><tr><td>Genotypes<sup>a</sup></td><td>Number of seedlings tested</td><td>Average resistance score</td><td>Significance<sup>b</sup></td></tr><tr><td colspan="4">Reaction to BPH biotype 4 (2009&#8211;2014)</td></tr><tr><td> CR2711&#8211;76</td><td>201</td><td>2.33</td><td>a</td></tr><tr><td> Jaya</td><td>207</td><td>7.99</td><td>b</td></tr><tr><td> F<sub>1</sub> (Jaya/CR2711&#8211;76)</td><td>52</td><td>1.33</td><td>a</td></tr><tr><td> PTB-33</td><td>206</td><td>4.03</td><td>a</td></tr><tr><td colspan="4">Reaction to Laguna BPH colony (2013&#8211;2015)</td></tr><tr><td> CR2711&#8211;76</td><td>199</td><td>3.87</td><td>b</td></tr><tr><td> Jaya</td><td>176</td><td>8.91</td><td>a</td></tr><tr><td> F<sub>1</sub> (Jaya/CR2711&#8211;76)</td><td>24</td><td>2.88</td><td>b</td></tr><tr><td> Rathu Heenati</td><td>210</td><td>3.11</td><td>b</td></tr><tr><td> TN-1</td><td>272</td><td>9.01</td><td>a</td></tr></table>
<table><tr><td>Genotypesa</td><td>Number of seedlings tested</td><td>Average resistance score</td><td>Significanceb</td></tr><tr><td colspan="4">Reaction to BPH biotype 4 (2009–2014)</td></tr><tr><td>CR2711–76</td><td>201</td><td>2.33</td><td>a</td></tr><tr><td>Jaya</td><td>207</td><td>7.99</td><td>b</td></tr><tr><td>F1 (Jaya/CR2711–76)</td><td>52</td><td>1.33</td><td>a</td></tr><tr><td>PTB-33</td><td>206</td><td>4.03</td><td>a</td></tr><tr><td colspan="4">Reaction to Laguna BPH colony (2013–2015)</td></tr><tr><td>CR2711–76</td><td>199</td><td>3.87</td><td>b</td></tr><tr><td>Jaya</td><td>176</td><td>8.91</td><td>a</td></tr><tr><td>F1 (Jaya/CR2711–76)</td><td>24</td><td>2.88</td><td>b</td></tr></table>
<table><tr><td>Genotypesa</td><td>Number of seedlings tested</td><td>Average resistance score</td><td>Significanceb</td></tr><tr><td>Rathu Heenati</td><td>210</td><td>3.11</td><td>b</td></tr><tr><td>TN-1</td><td>272</td><td>9.01</td><td>a</td></tr></table>
c813414656358da80060b059c87e4d7bcc1dc98f3fc2845f02186e5d97773143.png
simple
<table><tr><td>Chromosomal region</td><td>Fragile site (FS)</td><td>FS type<sup>a</sup></td><td>BAC-probe</td><td>Co-localization of FA breakpoints and FS</td></tr><tr><td>1p13.3</td><td>FRA1N</td><td>Aphidicolin<sup>b</sup></td><td>RP11-242D10</td><td>+</td></tr><tr><td>1q21.2</td><td>FRA1F</td><td>Aphidicolin</td><td>RP11-301 M17</td><td>+</td></tr><tr><td>1q42.2</td><td>Near FRA1H</td><td>Azacytidin</td><td>RP11-109G24</td><td>&#8722;</td></tr><tr><td>2q35</td><td>FRA2U</td><td>Aphidicolin</td><td>RP11-316O14</td><td>+</td></tr><tr><td>3p14.2</td><td>FRA3B</td><td>Aphidicolin</td><td>RP11-129 K20</td><td>+</td></tr><tr><td>3p21.31</td><td>FRA3H</td><td>New nomenclature<sup>c</sup></td><td>RP11-787O14RP11-159A17</td><td>+</td></tr><tr><td>3q27.1</td><td>FRA3C</td><td>Aphidicolin</td><td>RP11-110C15</td><td>+</td></tr><tr><td>5q13.2</td><td>FRA5K</td><td>New nomenclature<sup>d</sup></td><td>RP11-497H16</td><td>+</td></tr><tr><td>5q33.2</td><td>FRA5O</td><td>New nomenclature<sup>d</sup></td><td>RP11-265I24RP11-494C5</td><td>+</td></tr><tr><td>7q22.3</td><td>FRA7F</td><td>Aphidicolin</td><td>CTB-20D2</td><td>+</td></tr><tr><td>7q32.3</td><td>FRA7H</td><td>Aphidicolin</td><td>RP11-138A9RP11-36B6</td><td>+</td></tr><tr><td>11q13</td><td>FRA11H</td><td>Aphidicolin</td><td>RP11-449G14</td><td>+</td></tr><tr><td>14q24.3</td><td>FRA14G</td><td>Aphidicolin<sup>b</sup></td><td>RP3-414A15</td><td>+</td></tr><tr><td>16q22.1</td><td>FRA16C, FRA16B</td><td>Aphidicolin</td><td>RP11-106 J23</td><td>+</td></tr><tr><td>16q23</td><td>FRA16D</td><td>Aphidicolin</td><td>RP11-358 L22</td><td>+</td></tr><tr><td>18q21.3</td><td>FRA18B</td><td>Aphidicolin</td><td>RP11-15C15</td><td>+</td></tr></table>
<table><tr><td>Chromosomal region</td><td>Fragile site (FS)</td><td>FS typea</td><td>BAC-probe</td><td>Co-localization of FA breakpoints and FS</td></tr><tr><td>1p13.3</td><td>FRA1N</td><td>Aphidicolinb</td><td>RP11-242D10</td><td>+</td></tr><tr><td>1q21.2</td><td>FRA1F</td><td>Aphidicolin</td><td>RP11-301 M17</td><td>+</td></tr></table>
<table><tr><td>1q42.2</td><td>Near FRA1H</td><td>Azacytidin</td><td>RP11-109G24</td><td>−</td></tr><tr><td>2q35</td><td>FRA2U</td><td>Aphidicolin</td><td>RP11-316O14</td><td>+</td></tr><tr><td>3p14.2</td><td>FRA3B</td><td>Aphidicolin</td><td>RP11-129 K20</td><td>+</td></tr><tr><td>3p21.31</td><td>FRA3H</td><td>New nomenclaturec</td><td>RP11-787O14RP11-159A17</td><td>+</td></tr><tr><td>3q27.1</td><td>FRA3C</td><td>Aphidicolin</td><td>RP11-110C15</td><td>+</td></tr><tr><td>5q13.2</td><td>FRA5K</td><td>New nomenclatured</td><td>RP11-497H16</td><td>+</td></tr><tr><td>5q33.2</td><td>FRA5O</td><td>New nomenclatured</td><td>RP11-265I24RP11-494C5</td><td>+</td></tr><tr><td>7q22.3</td><td>FRA7F</td><td>Aphidicolin</td><td>CTB-20D2</td><td>+</td></tr><tr><td>7q32.3</td><td>FRA7H</td><td>Aphidicolin</td><td>RP11-138A9RP11-36B6</td><td>+</td></tr><tr><td>11q13</td><td>FRA11H</td><td>Aphidicolin</td><td>RP11-449G14</td><td>+</td></tr><tr><td>14q24.3</td><td>FRA14G</td><td>Aphidicolinb</td><td>RP3-414A15</td><td>+</td></tr><tr><td>16q22.1</td><td>FRA16C, FRA16B</td><td>Aphidicolin</td><td>RP11-106 J23</td><td>+</td></tr><tr><td>16q23</td><td>FRA16D</td><td>Aphidicolin</td><td>RP11-358 L22</td><td>+</td></tr><tr><td>18q21.3</td><td>FRA18B</td><td>Aphidicolin</td><td>RP11-15C15</td><td>+</td></tr></table>
b45b9536e49eecde86701c22ba47eb0509443d7debe9386b06731fa1fc80d48d.png
complex
<table><tr><td>Stage of prostate cancer</td><td>Hormonal agent</td><td>Function</td><td>Year of FDA approval</td><td>Reference</td></tr><tr><td rowspan="8">Advanced, hormone nai&#776;ve</td><td>Goserelin acetate</td><td>GnRH agonist</td><td>1989</td><td>[27, 28]</td></tr><tr><td>Leuprolide acetate</td><td>GnRH agonist</td><td>1989</td><td>[27, 29]</td></tr><tr><td>Histrelin acetate</td><td>GnRH agonist</td><td>1991</td><td>[27, 30]</td></tr><tr><td>Triptorelin pamoate</td><td>GnRH agonist</td><td>2000</td><td>[27, 31]</td></tr><tr><td>Abarelix</td><td>GnRH antagonist</td><td>2003</td><td>[27, 48]</td></tr><tr><td>Degarelix</td><td>GnRH antagonist</td><td>2008</td><td>[27, 49]</td></tr><tr><td>Bicalutamide</td><td>AR antagonist</td><td>1995</td><td>[27, 126]</td></tr><tr><td>Flutamide</td><td>AR antagonist</td><td>1989</td><td>[27, 127]</td></tr><tr><td rowspan="4">Castrate-resistant</td><td rowspan="2">Abiraterone acetate</td><td rowspan="2">CYP17 inhibitor</td><td>2011<sup>b</sup></td><td>[27, 94]</td></tr><tr><td>2012<sup>a</sup></td><td>[96, 99]</td></tr><tr><td rowspan="2">Enzalutamide</td><td rowspan="2">AR antagonist</td><td>2012<sup>b</sup></td><td>[27, 101]</td></tr><tr><td>2014<sup>a</sup></td><td>[102, 128]</td></tr></table>
<table><tr><td>Stage of prostate cancer</td><td>Hormonal agent</td><td>Function</td><td>Year of FDA approval</td><td>Reference</td></tr><tr><td>Advanced, hormone naïve</td><td>Goserelin acetate</td><td>GnRH agonist</td><td>1989</td><td>[27, 28]</td></tr></table>
<table><tr><td>Stage of prostate cancer</td><td>Hormonal agent</td><td>Function</td><td>Year of FDA approval</td><td>Reference</td></tr><tr><td rowspan="7">Advanced, hormone naïve</td><td>Leuprolide acetate</td><td>GnRH agonist</td><td>1989</td><td>[27, 29]</td></tr><tr><td>Histrelin acetate</td><td>GnRH agonist</td><td>1991</td><td>[27, 30]</td></tr><tr><td>Triptorelin pamoate</td><td>GnRH agonist</td><td>2000</td><td>[27, 31]</td></tr><tr><td>Abarelix</td><td>GnRH antagonist</td><td>2003</td><td>[27, 48]</td></tr><tr><td>Degarelix</td><td>GnRH antagonist</td><td>2008</td><td>[27, 49]</td></tr><tr><td>Bicalutamide</td><td>AR antagonist</td><td>1995</td><td>[27, 126]</td></tr><tr><td>Flutamide</td><td>AR antagonist</td><td>1989</td><td>[27, 127]</td></tr><tr><td rowspan="4">Castrate-resistant</td><td rowspan="2">Abiraterone acetate</td><td rowspan="2">CYP17 inhibitor</td><td>2011b</td><td>[27, 94]</td></tr><tr><td>2012a</td><td>[96, 99]</td></tr><tr><td rowspan="2">Enzalutamide</td><td rowspan="2">AR antagonist</td><td>2012b</td><td>[27, 101]</td></tr><tr><td>2014a</td><td>[102, 128]</td></tr></table>
fb3cdef3033cdf7d4af2ca114a1f4c8cbe3eb5c8b6a6db7451c30eedcffc0e54.png
simple
<table><tr><td>MIGS ID</td><td>Property</td><td>Term</td><td>Evidence code<sup>a</sup></td></tr><tr><td></td><td>Classification</td><td>Domain <i>Bacteria</i></td><td>TAS [38]</td></tr><tr><td></td><td></td><td>Phylum &#8220;<i>Nitrospirae</i>&#8221;</td><td>TAS [38]</td></tr><tr><td></td><td></td><td>Class &#8220;<i>Nitrospira</i>&#8221;</td><td>TAS [38]</td></tr><tr><td></td><td></td><td>Order &#8220;<i>Nitrospirales</i>&#8221;</td><td>TAS [38]</td></tr><tr><td></td><td></td><td>Family &#8220;<i>Nitrospiraceae</i>&#8221;</td><td>TAS [1, 38]</td></tr><tr><td></td><td></td><td>Genus <i>Leptospirillum</i></td><td>TAS [39]</td></tr><tr><td></td><td></td><td>Species <i>Leptospirillum ferriphilum</i></td><td>TAS [5]</td></tr><tr><td></td><td></td><td>Strain Sp-Cl</td><td>TAS [5]</td></tr><tr><td></td><td>Gram stain</td><td>Negative</td><td>TAS [5]</td></tr><tr><td></td><td>Cell shape</td><td>Curved rod</td><td>IDA</td></tr><tr><td></td><td>Motility</td><td>Motile</td><td>TAS [5]</td></tr><tr><td></td><td>Sporulation</td><td>Non-spore forming</td><td>TAS [5]</td></tr><tr><td></td><td>Temperature range</td><td>25&#176; to 45 &#176;C</td><td>NAS</td></tr><tr><td></td><td>Optimum temperature</td><td>30&#176; to 37 &#176;C</td><td>NAS</td></tr><tr><td></td><td>pH range, optimum</td><td>1.3 to 2.0; NA</td><td>IDA</td></tr><tr><td></td><td>Carbon source</td><td>CO<sub>2</sub></td><td>IDA</td></tr><tr><td>MIGS-6</td><td>Habitat</td><td>chloride, metal-rich and acidic environment</td><td>IDA</td></tr><tr><td>MIGS-6.3</td><td>Salinity</td><td>0-12 g/L Cl-</td><td>IDA</td></tr><tr><td>MIGS-22</td><td>Oxygen requirement</td><td>Aerobic</td><td>TAS [5]</td></tr><tr><td>MIGS-15</td><td>Biotic relationship</td><td>Free-living</td><td>IDA</td></tr><tr><td>MIGS-14</td><td>Pathogenicity</td><td>None</td><td>TAS [5, 22]</td></tr><tr><td>MIGS-4</td><td>Geographic location</td><td>Spence mine, Atacama Desert, Chile</td><td>IDA</td></tr><tr><td>MIGS-5</td><td>Sample collection</td><td>2007</td><td>IDA</td></tr><tr><td>MIGS-4.1</td><td>Latitude</td><td>22&#176;.81 S</td><td>IDA</td></tr><tr><td>MIGS-4.2</td><td>Longitude</td><td>69&#176;.26 W</td><td>IDA</td></tr><tr><td>MIGS-4.4</td><td>Altitude</td><td>1700</td><td>IDA</td></tr></table>
<table><tr><td>MIGS ID</td><td>Property</td><td>Term</td><td>Evidence codea</td></tr><tr><td></td><td>Classification</td><td>Domain Bacteria</td><td>TAS [38]</td></tr><tr><td></td><td></td><td>Phylum “Nitrospirae”</td><td>TAS [38]</td></tr><tr><td></td><td></td><td>Class “Nitrospira”</td><td>TAS [38]</td></tr><tr><td></td><td></td><td>Order “Nitrospirales”</td><td>TAS [38]</td></tr><tr><td></td><td></td><td>Family “Nitrospiraceae”</td><td>TAS [1, 38]</td></tr><tr><td></td><td></td><td>Genus Leptospirillum</td><td>TAS [39]</td></tr><tr><td></td><td></td><td>Species Leptospirillum ferriphilum</td><td>TAS [5]</td></tr><tr><td></td><td></td><td>Strain Sp-Cl</td><td>TAS [5]</td></tr><tr><td></td><td>Gram stain</td><td>Negative</td><td>TAS [5]</td></tr><tr><td></td><td>Cell shape</td><td>Curved rod</td><td>IDA</td></tr></table>
<table><tr><td>MIGS ID</td><td>Property</td><td>Term</td><td>Evidence codea</td></tr><tr><td></td><td>Motility</td><td>Motile</td><td>TAS [5]</td></tr><tr><td></td><td>Sporulation</td><td>Non-spore forming</td><td>TAS [5]</td></tr><tr><td></td><td>Temperature range</td><td>25° to 45 °C</td><td>NAS</td></tr><tr><td></td><td>Optimum temperature</td><td>30° to 37 °C</td><td>NAS</td></tr><tr><td></td><td>pH range, optimum</td><td>1.3 to 2.0; NA</td><td>IDA</td></tr><tr><td></td><td>Carbon source</td><td>CO2</td><td>IDA</td></tr><tr><td>MIGS-6</td><td>Habitat</td><td>chloride, metal-rich and acidic environment</td><td>IDA</td></tr><tr><td>MIGS-6.3</td><td>Salinity</td><td>0-12 g/L Cl-</td><td>IDA</td></tr><tr><td>MIGS-22</td><td>Oxygen requirement</td><td>Aerobic</td><td>TAS [5]</td></tr><tr><td>MIGS-15</td><td>Biotic relationship</td><td>Free-living</td><td>IDA</td></tr><tr><td>MIGS-14</td><td>Pathogenicity</td><td>None</td><td>TAS [5, 22]</td></tr><tr><td>MIGS-4</td><td>Geographic location</td><td>Spence mine, Atacama Desert, Chile</td><td>IDA</td></tr><tr><td>MIGS-5</td><td>Sample collection</td><td>2007</td><td>IDA</td></tr><tr><td>MIGS-4.1</td><td>Latitude</td><td>22°.81 S</td><td>IDA</td></tr><tr><td>MIGS-4.2</td><td>Longitude</td><td>69°.26 W</td><td>IDA</td></tr><tr><td>MIGS-4.4</td><td>Altitude</td><td>1700</td><td>IDA</td></tr></table>
d0ce01b781f40bc01905cf62b71906cdae51a1554fdf818970f4820d5fe8b94e.png
simple
<table><tr><td>Dataset</td><td>Oct 2006</td><td>Oct 2008</td><td>2008&#8211;2006</td><td>2008&#8211;2006[%]</td><td>Filtration2008</td></tr><tr><td>GVKBIO</td><td>1488288</td><td>2054151</td><td>565863</td><td>38%</td><td>-8%</td></tr><tr><td>GVKBIO Journals</td><td>542858</td><td>658198</td><td>115340</td><td>21%</td><td>-8%</td></tr><tr><td>GVKBIO patents</td><td>1034548</td><td>1484218</td><td>449670</td><td>43%</td><td>-7%</td></tr><tr><td>GVKBIO DD</td><td>1933</td><td>3675</td><td>1742</td><td>90%</td><td>-4%</td></tr><tr><td>GVKBIO CCD</td><td>n/a</td><td>8864</td><td>n/a</td><td>n/a</td><td>-1%</td></tr><tr><td>GVKBIO BACE1</td><td>n/a</td><td>5228</td><td>n/a</td><td>n/a</td><td>-11%</td></tr><tr><td>GVKBIO BACE1 journals</td><td>n/a</td><td>389</td><td>n/a</td><td>n/a</td><td>-6%</td></tr><tr><td>GVKBIO BACE1 patents</td><td>n/a</td><td>4901</td><td>n/a</td><td>n/a</td><td>-11%</td></tr><tr><td>WOMBAT</td><td>128120</td><td>180856</td><td>52736</td><td>41%</td><td>-18%</td></tr><tr><td>PubChem</td><td>7268193</td><td>14965539</td><td>7697346</td><td>106%</td><td>-23%</td></tr><tr><td>PubChem Prous</td><td>3318</td><td>4652</td><td>1334</td><td>40%</td><td>-2%</td></tr><tr><td>PubChem PDB</td><td>5626</td><td>5706</td><td>n/a</td><td>n/a</td><td>-8%</td></tr><tr><td>PubChem actives</td><td>35671</td><td>7472</td><td>n/a</td><td>n/a</td><td>-3%</td></tr><tr><td>PubChem pharmacol</td><td>6070</td><td>5311</td><td>n/a</td><td>n/a</td><td>-63%</td></tr><tr><td>PubChem MLSMR</td><td>n/a</td><td>233284</td><td>n/a</td><td>n/a</td><td>-1%</td></tr><tr><td>PubChem BindingDB</td><td>n/a</td><td>24203</td><td>n/a</td><td>n/a</td><td>-4%</td></tr><tr><td>PubChem ChEBI</td><td>n/a</td><td>7428</td><td>n/a</td><td>n/a</td><td>-31%</td></tr><tr><td>DrugBank</td><td>3723</td><td>4545</td><td>822</td><td>22%</td><td>-7%</td></tr><tr><td>DrugBank approved</td><td>1018</td><td>1341</td><td>323</td><td>32%</td><td>-3%</td></tr><tr><td>DrugBank experimental</td><td>1737</td><td>2999</td><td>1262</td><td>73%</td><td>-6%</td></tr><tr><td>DNP</td><td>131831</td><td>144383</td><td>12552</td><td>10%</td><td>-26%</td></tr><tr><td>MDDR</td><td>159867</td><td>176600</td><td>16733</td><td>10%</td><td>-4%</td></tr><tr><td>MDDR launched</td><td>1118</td><td>1435</td><td>317</td><td>28%</td><td>-5%</td></tr></table>
<table><tr><td>Dataset</td><td>Oct 2006</td><td>Oct 2008</td><td>2008–2006</td><td>2008–2006[%]</td><td>Filtration2008</td></tr><tr><td>GVKBIO</td><td>1488288</td><td>2054151</td><td>565863</td><td>38%</td><td>-8%</td></tr><tr><td>GVKBIO Journals</td><td>542858</td><td>658198</td><td>115340</td><td>21%</td><td>-8%</td></tr><tr><td>GVKBIO patents</td><td>1034548</td><td>1484218</td><td>449670</td><td>43%</td><td>-7%</td></tr><tr><td>GVKBIO DD</td><td>1933</td><td>3675</td><td>1742</td><td>90%</td><td>-4%</td></tr><tr><td>GVKBIO CCD</td><td>n/a</td><td>8864</td><td>n/a</td><td>n/a</td><td>-1%</td></tr><tr><td>GVKBIO BACE1</td><td>n/a</td><td>5228</td><td>n/a</td><td>n/a</td><td>-11%</td></tr><tr><td>GVKBIO BACE1 journals</td><td>n/a</td><td>389</td><td>n/a</td><td>n/a</td><td>-6%</td></tr></table>
<table><tr><td>GVKBIO BACE1 patents</td><td>n/a</td><td>4901</td><td>n/a</td><td>n/a</td><td>-11%</td></tr><tr><td>WOMBAT</td><td>128120</td><td>180856</td><td>52736</td><td>41%</td><td>-18%</td></tr><tr><td>PubChem</td><td>7268193</td><td>14965539</td><td>7697346</td><td>106%</td><td>-23%</td></tr><tr><td>PubChem Prous</td><td>3318</td><td>4652</td><td>1334</td><td>40%</td><td>-2%</td></tr><tr><td>PubChem PDB</td><td>5626</td><td>5706</td><td>n/a</td><td>n/a</td><td>-8%</td></tr><tr><td>PubChem actives</td><td>35671</td><td>7472</td><td>n/a</td><td>n/a</td><td>-3%</td></tr><tr><td>PubChem pharmacol</td><td>6070</td><td>5311</td><td>n/a</td><td>n/a</td><td>-63%</td></tr><tr><td>PubChem MLSMR</td><td>n/a</td><td>233284</td><td>n/a</td><td>n/a</td><td>-1%</td></tr><tr><td>PubChem BindingDB</td><td>n/a</td><td>24203</td><td>n/a</td><td>n/a</td><td>-4%</td></tr><tr><td>PubChem ChEBI</td><td>n/a</td><td>7428</td><td>n/a</td><td>n/a</td><td>-31%</td></tr><tr><td>DrugBank</td><td>3723</td><td>4545</td><td>822</td><td>22%</td><td>-7%</td></tr><tr><td>DrugBank approved</td><td>1018</td><td>1341</td><td>323</td><td>32%</td><td>-3%</td></tr><tr><td>DrugBank experimental</td><td>1737</td><td>2999</td><td>1262</td><td>73%</td><td>-6%</td></tr><tr><td>DNP</td><td>131831</td><td>144383</td><td>12552</td><td>10%</td><td>-26%</td></tr><tr><td>MDDR</td><td>159867</td><td>176600</td><td>16733</td><td>10%</td><td>-4%</td></tr><tr><td>MDDR launched</td><td>1118</td><td>1435</td><td>317</td><td>28%</td><td>-5%</td></tr></table>
68534b758430aaa1cc9526de3afc33cf6bf875d0f380cd0334744cb80ebb62f3.png
complex
<table><tr><td>SNPs</td><td>Allele</td><td>&#945;-helix</td><td>Extended strand</td><td>&#946;-turn</td><td>Random coil</td></tr><tr><td rowspan="2">c.271C &gt; T</td><td>C</td><td>32.92</td><td>13.04</td><td>4.35</td><td>49.69</td></tr><tr><td>T</td><td>32.3</td><td>13.04</td><td>5.59</td><td>49.07</td></tr></table>
<table><tr><td>SNPs</td><td>Allele</td><td>α-helix</td><td>Extended strand</td><td>β-turn</td><td>Random coil</td></tr><tr><td>c.271</td><td></td><td>32</td><td>13.0</td><td>4.3</td><td>49.6</td></tr></table>
<table><tr><td rowspan="2">C > T</td><td>C</td><td>.92</td><td>4</td><td>5</td><td>9</td></tr><tr><td>T</td><td>32.3</td><td>13.04</td><td>5.59</td><td>49.07</td></tr></table>
1cea78f04b9c70587473fc65b3b5f90ee0b6c73a8db973303cf9e4f64a82419a.png
simple
<table><tr><td>Health Behaviour</td><td>Total number</td><td>No. aimed at general population</td><td>No. aimed at community, school or work places</td><td>No. aimed at targeted populations or individuals</td></tr><tr><td>Smoking</td><td>48</td><td>5</td><td>6</td><td>Young people (11)Smokers (26)</td></tr><tr><td>Physical Activity</td><td>24</td><td>4</td><td>1</td><td>Young people (6)Older people (2)Adults over 18 years(8)</td></tr><tr><td>Alcohol</td><td>15</td><td>4</td><td>0</td><td>Young people (2)Pregnant women (1)Drink drivers (3)Problem drinkers (4)</td></tr><tr><td>Healthy eating</td><td>13</td><td>0</td><td>3</td><td>Young people (4)Older people (1)Pregnant women (1)Non specific (6)</td></tr><tr><td>Illicit drug use in young people</td><td>4</td><td>0</td><td>4</td><td>0</td></tr><tr><td>Sexual risk taking in young people</td><td>8</td><td>0</td><td>8</td><td>0</td></tr></table>
<table><tr><td>Health Behaviour</td><td>Total number</td><td>No. aimed at general population</td><td>No. aimed at community, school or work places</td><td>No. aimed at targeted populations or individuals</td></tr><tr><td>Smoking</td><td>48</td><td>5</td><td>6</td><td>Young people (11)Smokers (26)</td></tr><tr><td>Physical Activity</td><td>2</td><td>4</td><td>1</td><td>Young people (6)Older people (2)Adults over 18</td></tr></table>
<table><tr><td></td><td>4</td><td></td><td></td><td> years(8)</td></tr><tr><td>Alcohol</td><td>15</td><td>4</td><td>0</td><td>Young people (2)Pregnant women (1)Drink drivers (3)Problem drinkers (4)</td></tr><tr><td>Healthy eating</td><td>13</td><td>0</td><td>3</td><td>Young people (4)Older people (1)Pregnant women (1)Non specific (6)</td></tr><tr><td>Illicit drug use in young people</td><td>4</td><td>0</td><td>4</td><td>0</td></tr><tr><td>Sexual risk taking in young people</td><td>8</td><td>0</td><td>8</td><td>0</td></tr></table>
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<table><tr><td></td><td>Alfalfa</td><td>High nitrate-containing barley</td><td>Low nitrate-containing barley</td><td>NPA-containing milkvetch</td><td>NPOH-containing milkvetch</td></tr><tr><td>Crude protein (%)</td><td>17.3</td><td>13.8</td><td>6.4</td><td>10.0</td><td>9.6</td></tr><tr><td>Digestible crude protein (%)</td><td>12.6</td><td>9.4</td><td>2.5</td><td>5.8</td><td>5.4</td></tr><tr><td>Acid detergent fiber (%)</td><td>35.5</td><td>35.4</td><td>31.4</td><td>32.4</td><td>34.8</td></tr><tr><td>Neutral detergent fiber (%)</td><td>38.8</td><td>45.0</td><td>46.9</td><td>38.3</td><td>37.8</td></tr><tr><td>Total digestible nutrients (%)</td><td>60.2</td><td>59.1</td><td>59.5</td><td>60.0</td><td>58.1</td></tr><tr><td>Net energy lactation (Mcal/kg)</td><td>1.36</td><td>1.32</td><td>1.34</td><td>1.34</td><td>1.30</td></tr><tr><td>Net energy maintenance (Mcal/kg)</td><td>1.45</td><td>1.43</td><td>1.43</td><td>1.45</td><td>1.39</td></tr><tr><td>Net energy gain (Mcal/kg)</td><td>0.73</td><td>0.70</td><td>0.70</td><td>0.73</td><td>0.68</td></tr><tr><td><i>In vitro</i> true digestibility (%)</td><td>75.7</td><td>80.4</td><td>68.5</td><td>85.3</td><td>82.3</td></tr><tr><td>Ash (%)</td><td>10.2</td><td>9.3</td><td>5.4</td><td>7.4</td><td>7.9</td></tr><tr><td>Relative feed value</td><td>146.7</td><td>126.8</td><td>127.7</td><td>154.7</td><td>152.0</td></tr><tr><td>Nitrate<sup>a</sup> (%)</td><td>0.16</td><td>1.69</td><td>0.23</td><td>0.15</td><td>0.03</td></tr><tr><td colspan="6">Mineral analysis (NIR)</td></tr><tr><td>Calcium</td><td>1.22</td><td>0.69</td><td>0.48</td><td>0.72</td><td>0.77</td></tr><tr><td>Magnesium</td><td>0.29</td><td>0.15</td><td>0.04</td><td>0.11</td><td>0.11</td></tr><tr><td>Phosphorus</td><td>0.39</td><td>0.29</td><td>0.16</td><td>0.25</td><td>0.23</td></tr><tr><td>Potassium</td><td>2.92</td><td>2.23</td><td>1.52</td><td>1.64</td><td>1.50</td></tr></table>
<table><tr><td></td><td>Alfalfa</td><td>High nitrate-containing barley</td><td>Low nitrate-containing barley</td><td>NPA-containing milkvetch</td><td>NPOH-containing milkvetch</td></tr><tr><td>Crude protein (%)</td><td>17.3</td><td>13.8</td><td>6.4</td><td>10.0</td><td>9.6</td></tr><tr><td>Digestible crude protein (%)</td><td>12.6</td><td>9.4</td><td>2.5</td><td>5.8</td><td>5.4</td></tr><tr><td>Acid detergent fiber (%)</td><td>35.5</td><td>35.4</td><td>31.4</td><td>32.4</td><td>34.8</td></tr><tr><td>Neutral detergent fiber (%)</td><td>38.8</td><td>45.0</td><td>46.9</td><td>38.3</td><td>37.8</td></tr><tr><td>Total digestible nutrients (%)</td><td>60.2</td><td>59.1</td><td>59.5</td><td>60.0</td><td>58.1</td></tr><tr><td>Net energy lactation (Mcal/kg)</td><td>1.36</td><td>1.32</td><td>1.34</td><td>1.34</td><td>1.30</td></tr><tr><td>Net energy maintenance (Mcal/kg)</td><td>1.45</td><td>1.43</td><td>1.43</td><td>1.45</td><td>1.39</td></tr><tr><td>Net energy gain (Mcal/kg)</td><td>0.73</td><td>0.70</td><td>0.70</td><td>0.73</td><td>0.68</td></tr><tr><td>In vitro true digestibility (%)</td><td>75.7</td><td>80.4</td><td>68.5</td><td>85.3</td><td>82.3</td></tr></table>
<table><tr><td>Ash (%)</td><td>10.2</td><td>9.3</td><td>5.4</td><td>7.4</td><td>7.9</td></tr><tr><td>Relative feed value</td><td>146.7</td><td>126.8</td><td>127.7</td><td>154.7</td><td>152.0</td></tr><tr><td>Nitratea (%)</td><td>0.16</td><td>1.69</td><td>0.23</td><td>0.15</td><td>0.03</td></tr><tr><td colspan="6">Mineral analysis (NIR)</td></tr><tr><td>Calcium</td><td>1.22</td><td>0.69</td><td>0.48</td><td>0.72</td><td>0.77</td></tr><tr><td>Magnesium</td><td>0.29</td><td>0.15</td><td>0.04</td><td>0.11</td><td>0.11</td></tr><tr><td>Phosphorus</td><td>0.39</td><td>0.29</td><td>0.16</td><td>0.25</td><td>0.23</td></tr><tr><td>Potassium</td><td>2.92</td><td>2.23</td><td>1.52</td><td>1.64</td><td>1.50</td></tr></table>
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<table><tr><td>Strain</td><td></td></tr><tr><td><i>Bifidobacterium adolescentis</i> DSM 20083<sup>T</sup></td><td></td></tr><tr><td><i>Bifidobacterium adolescentis</i> DSM 20086</td><td></td></tr><tr><td><i>Bifidobacterium adolescentis</i> DSM 20087</td><td></td></tr><tr><td><i>Bifidobacterium animalis</i>subsp. <i>lactis</i> NRRL B-41405</td><td></td></tr><tr><td><i>Bifidobacterium animalis</i>subps. <i>animalis</i> NRRL B-41406<sup>T</sup></td><td></td></tr><tr><td><i>Bifidobacterium bifidum</i> DSM 20456<sup>T</sup></td><td></td></tr><tr><td><i>Bifidobacterium breve</i> DSM 20091</td><td></td></tr><tr><td><i>Bifidobacterium breve</i> NRRL B-41408<sup>T</sup></td><td></td></tr><tr><td><i>Bifidobacterium catenulatum</i> DSM 20224</td><td></td></tr><tr><td><i>Bifidobacterium longum</i>subsp. <i>infantis</i> ATCC 15697<sup>T</sup></td><td></td></tr><tr><td><i>Bifidobacterium longum</i>subsp. <i>longum</i> NRRL B-41409<sup>T</sup></td><td></td></tr><tr><td><i>Bifidobacterium longum</i>subsp. <i>suis</i> NRRL B-41407<sup>T</sup></td><td></td></tr><tr><td><i>Bifidobacterium pseudocatenulatum</i> DSM 20439</td><td></td></tr><tr><td><i>Bifidobacterium pseudolongum</i>subsp. <i>globosum</i> DSM 20092<sup>T</sup></td><td></td></tr><tr><td><i>Bifidobacterium pseudolongum</i>subsp. <i>pseudolongum</i> DSM 20094</td><td></td></tr><tr><td><i>Bifidobacterium pseudolongum</i>subsp. <i>pseudolongum</i> DSM 20095</td><td></td></tr><tr><td><i>Bifidobacterium pseudolongum</i>subsp. <i>pseudolongum</i> DSM 20099<sup>T</sup></td><td></td></tr></table>
<table><tr><td>Strain</td><td></td></tr><tr><td>Bifidobacterium adolescentis DSM 20083T</td><td></td></tr><tr><td>Bifidobacterium adolescentis DSM 20086</td><td></td></tr></table>
<table><tr><td>Strain</td><td></td></tr><tr><td>Bifidobacterium adolescentis DSM 20087</td><td></td></tr><tr><td>Bifidobacterium animalissubsp. lactis NRRL B-41405</td><td></td></tr><tr><td>Bifidobacterium animalissubps. animalis NRRL B-41406T</td><td></td></tr><tr><td>Bifidobacterium bifidum DSM 20456T</td><td></td></tr><tr><td>Bifidobacterium breve DSM 20091</td><td></td></tr><tr><td>Bifidobacterium breve NRRL B-41408T</td><td></td></tr><tr><td>Bifidobacterium catenulatum DSM 20224</td><td></td></tr><tr><td>Bifidobacterium longumsubsp. infantis ATCC 15697T</td><td></td></tr><tr><td>Bifidobacterium longumsubsp. longum NRRL B-41409T</td><td></td></tr><tr><td>Bifidobacterium longumsubsp. suis NRRL B-41407T</td><td></td></tr><tr><td>Bifidobacterium pseudocatenulatum DSM 20439</td><td></td></tr><tr><td>Bifidobacterium pseudolongumsubsp. globosum DSM 20092T</td><td></td></tr><tr><td>Bifidobacterium pseudolongumsubsp. pseudolongum DSM 20094</td><td></td></tr><tr><td>Bifidobacterium pseudolongumsubsp. pseudolongum DSM 20095</td><td></td></tr><tr><td>Bifidobacterium pseudolongumsubsp. pseudolongum DSM 20099T</td><td></td></tr></table>
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<table><tr><td>University &amp; Library</td><td>Responded to phase 2</td></tr><tr><td>1. Charles Drew University of Medicine &amp; Science, Health Sciences Library</td><td>&#10003;</td></tr><tr><td>2. Loma Linda University Medical Center, Jesse Medical Library &amp; Information Center</td><td> </td></tr><tr><td>3. Oregon Health and Science University, Library</td><td>&#10003;</td></tr><tr><td>4. Stanford University Medical Center, Lane Medical Library</td><td> </td></tr><tr><td>5. University of Arizona (Tucson Campus), Arizona Health Sciences Library</td><td>&#10003;</td></tr><tr><td colspan="2">(University of Arizona (Phoenix Campus) Partnership of U of A &amp; ASU medical school dissolved mid-project. ASU counted as part of U of A)</td></tr><tr><td>6. University of California, Davis, Carlson Health Sciences Library</td><td> </td></tr><tr><td>7. University of California, Irvine, Science Library</td><td>&#10003;</td></tr><tr><td>8. University of California, Los Angeles, Biomedical Library</td><td>&#10003;</td></tr><tr><td colspan="2">(University of California, Riverside program is developing, with most services provided by UCLA and therefore, counted under UCLA)</td></tr><tr><td>9. University of California San Diego, Biomedical Library</td><td>&#10003;</td></tr><tr><td>10. University of California, San Francisco, Library</td><td>&#10003;</td></tr><tr><td>11. University of Colorado, Health Sciences Library</td><td>&#10003;</td></tr><tr><td>12. University of Hawaii at Manoa, Health Sciences Library</td><td> </td></tr><tr><td>13. University of Nevada Reno, Savitt Medical Library</td><td>&#10003;</td></tr><tr><td>14. University of New Mexico School of Medicine, Health Sciences Library and Informatics</td><td>&#10003;</td></tr><tr><td>15. University of Southern California, Norris Medical Library</td><td>&#10003;</td></tr><tr><td>16. University of Utah, Eccles Health Sciences Library</td><td>&#10003;</td></tr><tr><td>17. University of Washington, Health Sciences Library</td><td>&#10003;</td></tr></table>
<table><tr><td>University & Library</td><td>Responded to phase 2</td></tr><tr><td>1. Charles Drew University of Medicine & Science, Health Sciences Library</td><td>✓</td></tr><tr><td>2. Loma Linda University Medical Center, Jesse Medical Library & Information Center</td><td></td></tr><tr><td>3. Oregon Health and Science University, Library</td><td>✓</td></tr><tr><td>4. Stanford University Medical Center, Lane Medical Library</td><td></td></tr><tr><td>5. University of Arizona (Tucson Campus), Arizona Health Sciences Library</td><td>✓</td></tr><tr><td colspan="2">(University of Arizona (Phoenix Campus) Partnership of U of A & ASU medical school dissolved mid-project. ASU counted as part of U of A)</td></tr><tr><td>6. University of California, Davis, Carlson Health Sciences Library</td><td></td></tr><tr><td>7. University of California, Irvine, Science Library</td><td>✓</td></tr><tr><td>8. University of California, Los Angeles, Biomedical Library</td><td>✓</td></tr><tr><td colspan="2">(University of California, Riverside program is developing, with most services provided by UCLA and therefore, counted under UCLA)</td></tr><tr><td>9. University of California San Diego, Biomedical Library</td><td>✓</td></tr><tr><td>10. University of California, San Francisco, Library</td><td>✓</td></tr><tr><td>11. University of Colorado, Health Sciences Library</td><td>✓</td></tr><tr><td>12. University of Hawaii at Manoa, Health Sciences Library</td><td></td></tr><tr><td>13. University of Nevada Reno, Savitt Medical Library</td><td>✓</td></tr><tr><td>14. University of New Mexico School of Medicine, Health Sciences Library and Informatics</td><td>✓</td></tr><tr><td>15. University of Southern California, Norris Medical Library</td><td>✓</td></tr></table>
<table><tr><td>16. University of Utah, Eccles Health Sciences Library</td><td>✓</td></tr><tr><td>17. University of Washington, Health Sciences Library</td><td>✓</td></tr></table>
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<table><tr><td></td><td>Distribution between categories</td><td>Assumed hospitalization rate</td></tr><tr><td>No-test scenario</td><td></td><td>44.6%</td></tr><tr><td colspan="3">Test scenario</td></tr><tr><td> sFlt-1/PlGF ratio &#8805; 85 at weeks 20 + 0&#8211;33 + 6, or &#8805; 110 from week 34 onwards</td><td>19.60%</td><td>70.0%</td></tr><tr><td> sFlt-1/PlGF ratio &gt; 38 &#8722; &lt; 85 at weeks 20 + 0&#8211;33 + 6, or &gt; 38 &#8722; &lt; 110 from week 34 onwards</td><td>16.20%</td><td>57.6%</td></tr><tr><td> sFlt-1/PlGF ratio &#8804; 38</td><td>64.20%</td><td>1.5%</td></tr></table>
<table><tr><td></td><td>Distribution between categories</td><td>Assumed hospitalization rate</td></tr></table>
<table><tr><td>No-test scenario</td><td></td><td>44.6%</td></tr><tr><td colspan="3">Test scenario</td></tr><tr><td>sFlt-1/PlGF ratio ≥ 85 at weeks 20 + 0–33 + 6, or ≥ 110 from week 34 onwards</td><td>19.60%</td><td>70.0%</td></tr><tr><td>sFlt-1/PlGF ratio > 38 − < 85 at weeks 20 + 0–33 + 6, or > 38 − < 110 from week 34 onwards</td><td>16.20%</td><td>57.6%</td></tr><tr><td>sFlt-1/PlGF ratio ≤ 38</td><td>64.20%</td><td>1.5%</td></tr></table>
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<table><tr><td></td><td></td><td colspan="4">Fish or krill Oil: 1.3 g/d</td><td></td></tr><tr><td>Parameter</td><td></td><td>Overall (N = 66)</td><td>Treatment A Ethyl Ester (N = 22)</td><td>Treatment B Triglycerides (N = 22)</td><td>Treatment C krill Oil (N = 22)</td><td>p-value*</td></tr><tr><td>Gender</td><td>Female</td><td>48 (72.7 %)</td><td>17 (77.3 %)</td><td>13 (59.1 %)</td><td>18 (81.8 %)</td><td>0.2011</td></tr><tr><td></td><td>Male</td><td>18 (27.3 %)</td><td>5 (22.7 %)</td><td>9 (40.9 %)</td><td>4 (18.2 %)</td><td></td></tr><tr><td>Age (years)</td><td>N</td><td>66</td><td>22</td><td>22</td><td>22</td><td>0.4523</td></tr><tr><td></td><td>Mean (SEM)</td><td>35.45 (1.44)</td><td>37.41 (2.69)</td><td>35.95 (2.39)</td><td>33.00 (2.42)</td><td></td></tr><tr><td></td><td>Std Dev</td><td>11.72</td><td>12.64</td><td>11.21</td><td>11.37</td><td></td></tr><tr><td></td><td>Min, Max</td><td>19.00, 57.00</td><td>19.00, 57.00</td><td>19.00, 52.00</td><td>19.00, 55.00</td><td></td></tr><tr><td>Ethnicity</td><td>Not Hispanic or Latino</td><td>27 (40.9 %)</td><td>10 (45.5 %)</td><td>9 (40.9 %)</td><td>8 (36.4 %)</td><td>0.8286</td></tr><tr><td></td><td>Hispanic or Latino</td><td>39 (59.1 %)</td><td>12 (54.5 %)</td><td>13 (59.1 %)</td><td>14 (63.6 %)</td><td></td></tr><tr><td>Race</td><td>Asian</td><td>1 (1.5 %)</td><td>1 (4.5 %)</td><td>0 (0.0 %)</td><td>0 (0.0 %)</td><td>0.6239</td></tr><tr><td></td><td>Black or African American</td><td>7 (10.6 %)</td><td>2 (9.1 %)</td><td>3 (13.6 %)</td><td>2 (9.1 %)</td><td></td></tr><tr><td></td><td>White</td><td>57 (86.4 %)</td><td>19 (86.4 %)</td><td>18 (81.8 %)</td><td>20 (90.9 %)</td><td></td></tr><tr><td></td><td>Mixed: White, Black or African American</td><td>1 (1.5 %)</td><td>0 (0.0 %)</td><td>1 (4.5 %)</td><td>0 (0.0 %)</td><td></td></tr><tr><td>Weight (kg)</td><td>N</td><td>66</td><td>22</td><td>22</td><td>22</td><td>0.3480</td></tr><tr><td></td><td>Mean (SEM)</td><td>68.72 (1.43)</td><td>69.06 (2.83)</td><td>71.10 (2.55)</td><td>66.01 (1.96)</td><td></td></tr><tr><td></td><td>Std Dev</td><td>11.59</td><td>13.25</td><td>11.94</td><td>9.17</td><td></td></tr><tr><td></td><td>Min, Max</td><td>50.90, 111.20</td><td>50.90, 111.20</td><td>51.00, 89.00</td><td>52.80, 84.60</td><td></td></tr><tr><td>Height (cm)</td><td>N</td><td>66</td><td>22</td><td>22</td><td>22</td><td>0.2408</td></tr><tr><td></td><td>Mean (SEM)</td><td>164.35 (1.16)</td><td>164.98 (2.47)</td><td>166.39 (1.80)</td><td>161.68 (1.63)</td><td></td></tr><tr><td></td><td>Std Dev</td><td>9.45</td><td>11.59</td><td>8.44</td><td>7.66</td><td></td></tr><tr><td></td><td>Min, Max</td><td>149.50, 194.00</td><td>149.50, 194.00</td><td>153.00, 179.50</td><td>149.50, 181.00</td><td></td></tr><tr><td>BMI (kg/m^2)</td><td>N</td><td>66</td><td>22</td><td>22</td><td>22</td><td>0.9056</td></tr><tr><td></td><td>Mean (SEM)</td><td>25.32 (0.32)</td><td>25.22 (0.56)</td><td>25.53 (0.54)</td><td>25.22 (0.59)</td><td></td></tr><tr><td></td><td>Std Dev</td><td>2.60</td><td>2.62</td><td>2.54</td><td>2.75</td><td></td></tr><tr><td></td><td>Min, Max</td><td>19.80, 29.50</td><td>20.90, 29.50</td><td>20.80, 29.50</td><td>19.80, 29.20</td><td></td></tr></table>
<table><tr><td></td><td></td><td colspan="4">Fish or krill Oil: 1.3 g/d</td><td></td></tr><tr><td>Parameter</td><td></td><td>Overall (N = 66)</td><td>Treatment A Ethyl Ester (N = 22)</td><td>Treatment B Triglycerides (N = 22)</td><td>Treatment C krill Oil (N = 22)</td><td>p-value*</td></tr><tr><td>Gender</td><td>Female</td><td>48 (72.7 %)</td><td>17 (77.3 %)</td><td>13 (59.1 %)</td><td>18 (81.8 %)</td><td>0.2011</td></tr><tr><td></td><td>Male</td><td>18 (27.3 %)</td><td>5 (22.7 %)</td><td>9 (40.9 %)</td><td>4 (18.2 %)</td><td></td></tr><tr><td>Age (years)</td><td>N</td><td>66</td><td>22</td><td>22</td><td>22</td><td>0.4523</td></tr><tr><td></td><td>Mean (SEM)</td><td>35.45 (1.44)</td><td>37.41 (2.69)</td><td>35.95 (2.39)</td><td>33.00 (2.42)</td><td></td></tr><tr><td></td><td>Std Dev</td><td>11.72</td><td>12.64</td><td>11.21</td><td>11.37</td><td></td></tr><tr><td></td><td>Min, Max</td><td>19.00, 57.00</td><td>19.00, 57.00</td><td>19.00, 52.00</td><td>19.00, 55.00</td><td></td></tr></table>
<table><tr><td></td><td></td><td colspan="4">Fish or krill Oil: 1.3 g/d</td><td></td></tr><tr><td>Parameter</td><td></td><td>Overall (N = 66)</td><td>Treatment A Ethyl Ester (N = 22)</td><td>Treatment B Triglycerides (N = 22)</td><td>Treatment C krill Oil (N = 22)</td><td>p-value*</td></tr><tr><td>Ethnicity</td><td>Not Hispanic or Latino</td><td>27 (40.9 %)</td><td>10 (45.5 %)</td><td>9 (40.9 %)</td><td>8 (36.4 %)</td><td>0.8286</td></tr><tr><td></td><td>Hispanic or Latino</td><td>39 (59.1 %)</td><td>12 (54.5 %)</td><td>13 (59.1 %)</td><td>14 (63.6 %)</td><td></td></tr><tr><td>Race</td><td>Asian</td><td>1 (1.5 %)</td><td>1 (4.5 %)</td><td>0 (0.0 %)</td><td>0 (0.0 %)</td><td>0.6239</td></tr><tr><td></td><td>Black or African American</td><td>7 (10.6 %)</td><td>2 (9.1 %)</td><td>3 (13.6 %)</td><td>2 (9.1 %)</td><td></td></tr><tr><td></td><td>White</td><td>57 (86.4 %)</td><td>19 (86.4 %)</td><td>18 (81.8 %)</td><td>20 (90.9 %)</td><td></td></tr><tr><td></td><td>Mixed: White, Black or African American</td><td>1 (1.5 %)</td><td>0 (0.0 %)</td><td>1 (4.5 %)</td><td>0 (0.0 %)</td><td></td></tr><tr><td>Weight (kg)</td><td>N</td><td>66</td><td>22</td><td>22</td><td>22</td><td>0.3480</td></tr><tr><td></td><td>Mean (SEM)</td><td>68.72 (1.43)</td><td>69.06 (2.83)</td><td>71.10 (2.55)</td><td>66.01 (1.96)</td><td></td></tr><tr><td></td><td>Std Dev</td><td>11.59</td><td>13.25</td><td>11.94</td><td>9.17</td><td></td></tr><tr><td></td><td>Min, Max</td><td>50.90, 111.20</td><td>50.90, 111.20</td><td>51.00, 89.00</td><td>52.80, 84.60</td><td></td></tr><tr><td>Height (cm)</td><td>N</td><td>66</td><td>22</td><td>22</td><td>22</td><td>0.2408</td></tr><tr><td></td><td>Mean (SEM)</td><td>164.35 (1.16)</td><td>164.98 (2.47)</td><td>166.39 (1.80)</td><td>161.68 (1.63)</td><td></td></tr><tr><td></td><td>Std Dev</td><td>9.45</td><td>11.59</td><td>8.44</td><td>7.66</td><td></td></tr><tr><td></td><td>Min, Max</td><td>149.50, 194.00</td><td>149.50, 194.00</td><td>153.00, 179.50</td><td>149.50, 181.00</td><td></td></tr><tr><td>BMI (kg/m^2)</td><td>N</td><td>66</td><td>22</td><td>22</td><td>22</td><td>0.9056</td></tr><tr><td></td><td>Mean (SEM)</td><td>25.32 (0.32)</td><td>25.22 (0.56)</td><td>25.53 (0.54)</td><td>25.22 (0.59)</td><td></td></tr><tr><td></td><td>Std Dev</td><td>2.60</td><td>2.62</td><td>2.54</td><td>2.75</td><td></td></tr><tr><td></td><td>Min, Max</td><td>19.80, 29.50</td><td>20.90, 29.50</td><td>20.80, 29.50</td><td>19.80, 29.20</td><td></td></tr></table>
1b3351605843f4f237375795250c6268c7c6958a19ee667d12c5bef2a1921c76.png
complex
<table><tr><td> </td><td colspan="3">Preterm</td><td colspan="3">Term</td><td colspan="2">Preterm &amp; term compared</td></tr><tr><td colspan="9">Fat (g/dL)&#9830;</td></tr><tr><td>Time frame:</td><td>mean</td><td>SD</td><td>n</td><td>mean</td><td>SD</td><td>n</td><td>% difference</td><td>p-value</td></tr><tr><td>d 1-3</td><td>2.2</td><td>0.9</td><td>76</td><td>1.8</td><td>0.7</td><td>74</td><td>23</td><td>0.002</td></tr><tr><td>d 4-7</td><td>3.0</td><td>1.2</td><td>111</td><td>2.6</td><td>0.8</td><td>136</td><td>16</td><td>0.002</td></tr><tr><td>week 2</td><td>3.5</td><td>1.1</td><td>158</td><td>3.0</td><td>0.9</td><td>48</td><td>15</td><td>0.01</td></tr><tr><td>week 3-4</td><td>3.5</td><td>1.0</td><td>180</td><td>3.4</td><td>0.8</td><td>127</td><td>5</td><td>0.12</td></tr><tr><td>week 5-6</td><td>3.2</td><td>0.8</td><td>95</td><td>3.6</td><td>1.1</td><td>20</td><td>&#8722;11</td><td>0.07</td></tr><tr><td>week 7-9</td><td>3.3</td><td>0.9</td><td>120</td><td>3.4</td><td>0.8</td><td>83</td><td>&#8722;3</td><td>0.38</td></tr><tr><td>week 10-12</td><td>3.7</td><td>1.5</td><td>22</td><td>3.4</td><td>0.9</td><td>95</td><td>7</td><td>0.31</td></tr><tr><td colspan="9">Fat meta-analysis was limited to 24 hour collections.</td></tr><tr><td colspan="9">&#9830; References: [6,11,12,18,19,22,121-123,125,127,142,144,146]</td></tr><tr><td colspan="9">Lactose (kcal/dL)&#9830;&#9830;</td></tr><tr><td>Time frame:</td><td>mean</td><td>SD</td><td>n</td><td>mean</td><td>SD</td><td>n</td><td>% difference</td><td>p-value</td></tr><tr><td>d 1-3</td><td>5.1</td><td>0.7</td><td>95</td><td>5.6</td><td>0.6</td><td>59</td><td>&#8722;9</td><td>&lt; 0.00001*</td></tr><tr><td>d 4-7</td><td>6.3</td><td>1.1</td><td>114</td><td>6.0</td><td>1.0</td><td>281</td><td>4</td><td>0.009</td></tr><tr><td>week 2</td><td>5.7</td><td>0.8</td><td>231</td><td>6.2</td><td>0.6</td><td>100</td><td>&#8722;8</td><td>&lt; 0.00001*</td></tr><tr><td>week 3-4</td><td>6.0</td><td>0.5</td><td>225</td><td>6.7</td><td>0.7</td><td>193</td><td>&#8722;10</td><td>&lt; 0.00001*</td></tr><tr><td>week 5-6</td><td>5.8</td><td>0.6</td><td>104</td><td>6.1</td><td>1.0</td><td>22</td><td>&#8722;6</td><td>0.06</td></tr><tr><td>week 7-9</td><td>6.3</td><td>0.4</td><td>123</td><td>6.5</td><td>0.5</td><td>646</td><td>&#8722;2</td><td>&lt; 0.00001*</td></tr><tr><td>week 10-12</td><td>6.8</td><td>0.3</td><td>28</td><td>6.7</td><td>0.7</td><td>58</td><td>2</td><td>0.47</td></tr><tr><td colspan="9">&#9830;&#9830;References: [6,11,12,19,21-23,121,123,129-131,135,140,143,146,147]</td></tr><tr><td colspan="5">Oligosaccharides (g/dL) &#9830;&#9830;&#9830;</td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>Time frame:</td><td>mean</td><td>SD</td><td>n</td><td>mean</td><td>SD</td><td>n</td><td>% difference</td><td>p-value</td></tr><tr><td>d 1-3</td><td>-</td><td>-</td><td>-</td><td>1.6</td><td>0.2</td><td>9</td><td>-</td><td>-</td></tr><tr><td>days 4-7</td><td>2.1</td><td>0.4</td><td>89</td><td>1.9</td><td>0.4</td><td>93</td><td>12</td><td>0.0009</td></tr><tr><td>week 2 (days 7&#8211;14)</td><td>2.1</td><td>0.5</td><td>89</td><td>1.9</td><td>0.4</td><td>54</td><td>7</td><td>0.004</td></tr><tr><td>week 3&#8211;4 (days 15&#8211;30)</td><td>1.7</td><td>0.3</td><td>152</td><td>1.6</td><td>0.3</td><td>46</td><td>12</td><td>0.27</td></tr><tr><td>week 5-6</td><td>-</td><td>-</td><td>-</td><td>1.4</td><td>0.3</td><td>46</td><td>-</td><td>-</td></tr><tr><td>week 7-9</td><td>-</td><td>-</td><td>-</td><td>1.3</td><td>0.3</td><td>46</td><td>-</td><td>-</td></tr><tr><td>week 10-12</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td colspan="9">&#9830;&#9830;&#9830;References: [140,141,143,147].</td></tr></table>
<table><tr><td></td><td colspan="3">Preterm</td><td colspan="2">Term</td></tr><tr><td colspan="6">Fat (g/dL)♦</td></tr><tr><td>Time frame:</td><td>mean</td><td>SD</td><td>n</td><td>mean</td><td>SD</td></tr><tr><td>d 1-3</td><td>2.2</td><td>0.9</td><td>76</td><td>1.8</td><td>0.7</td></tr><tr><td>d 4-7</td><td>3.0</td><td>1.2</td><td>111</td><td>2.6</td><td>0.8</td></tr><tr><td>week 2</td><td>3.5</td><td>1.1</td><td>158</td><td>3.0</td><td>0.9</td></tr><tr><td>week 3-4</td><td>3.5</td><td>1.0</td><td>180</td><td>3.4</td><td>0.8</td></tr><tr><td>week 5-6</td><td>3.2</td><td>0.8</td><td>95</td><td>3.6</td><td>1.1</td></tr><tr><td>week 7-9</td><td>3.3</td><td>0.9</td><td>120</td><td>3.4</td><td>0.8</td></tr><tr><td>week 10-12</td><td>3.7</td><td>1.5</td><td>22</td><td>3.4</td><td>0.9</td></tr><tr><td colspan="6">Fat meta-analysis was limited to 24 hour collections.</td></tr><tr><td colspan="6">♦ References: [6,11,12,18,19,22,121-123,125,127,142,144,146]</td></tr><tr><td colspan="6">Lactose (kcal/dL)♦♦</td></tr><tr><td>Time frame:</td><td>mean</td><td>SD</td><td>n</td><td>mean</td><td>SD</td></tr><tr><td>d 1-3</td><td>5.1</td><td>0.7</td><td>95</td><td>5.6</td><td>0.6</td></tr><tr><td>d 4-7</td><td>6.3</td><td>1.1</td><td>114</td><td>6.0</td><td>1.0</td></tr><tr><td>week 2</td><td>5.7</td><td>0.8</td><td>231</td><td>6.2</td><td>0.6</td></tr><tr><td>week 3-4</td><td>6.0</td><td>0.5</td><td>225</td><td>6.7</td><td>0.7</td></tr><tr><td>week 5-6</td><td>5.8</td><td>0.6</td><td>104</td><td>6.1</td><td>1.0</td></tr><tr><td>week 7-9</td><td>6.3</td><td>0.4</td><td>123</td><td>6.5</td><td>0.5</td></tr><tr><td>week 10-12</td><td>6.8</td><td>0.3</td><td>28</td><td>6.7</td><td>0.7</td></tr><tr><td colspan="6">♦♦References: [6,11,12,19,21-23,121,123,129-131,135,140,143,146,147]</td></tr><tr><td colspan="5">Oligosaccharides (g/dL) ♦♦♦</td><td></td></tr><tr><td>Time frame:</td><td>mean</td><td>SD</td><td>n</td><td>mean</td><td>SD</td></tr><tr><td>d 1-3</td><td>-</td><td>-</td><td>-</td><td>1.6</td><td>0.2</td></tr><tr><td>days 4-7</td><td>2.1</td><td>0.4</td><td>89</td><td>1.9</td><td>0.4</td></tr><tr><td>week 2 (days 7–14)</td><td>2.1</td><td>0.5</td><td>89</td><td>1.9</td><td>0.4</td></tr><tr><td>week 3–4 (days 15–30)</td><td>1.7</td><td>0.3</td><td>152</td><td>1.6</td><td>0.3</td></tr><tr><td>week 5-6</td><td>-</td><td>-</td><td>-</td><td>1.4</td><td>0.3</td></tr><tr><td>week 7-9</td><td>-</td><td>-</td><td>-</td><td>1.3</td><td>0.3</td></tr><tr><td>week 10-12</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td colspan="6">♦♦♦References: [140,141,143,147].</td></tr></table>
<table><tr><td>Term</td><td colspan="2">Preterm & term compared</td></tr><tr><td colspan="3">Fat (g/dL)♦</td></tr><tr><td>n</td><td>% difference</td><td>p-value</td></tr><tr><td>74</td><td>23</td><td>0.002</td></tr><tr><td>136</td><td>16</td><td>0.002</td></tr><tr><td>48</td><td>15</td><td>0.01</td></tr><tr><td>127</td><td>5</td><td>0.12</td></tr><tr><td>20</td><td>−11</td><td>0.07</td></tr><tr><td>83</td><td>−3</td><td>0.38</td></tr><tr><td>95</td><td>7</td><td>0.31</td></tr><tr><td colspan="3">Fat meta-analysis was limited to 24 hour collections.</td></tr><tr><td colspan="3">♦ References: [6,11,12,18,19,22,121-123,125,127,142,144,146]</td></tr><tr><td colspan="3">Lactose (kcal/dL)♦♦</td></tr><tr><td>n</td><td>% difference</td><td>p-value</td></tr><tr><td>59</td><td>−9</td><td>< 0.00001*</td></tr><tr><td>281</td><td>4</td><td>0.009</td></tr><tr><td>100</td><td>−8</td><td>< 0.00001*</td></tr><tr><td>193</td><td>−10</td><td>< 0.00001*</td></tr><tr><td>22</td><td>−6</td><td>0.06</td></tr><tr><td>646</td><td>−2</td><td>< 0.00001*</td></tr><tr><td>58</td><td>2</td><td>0.47</td></tr><tr><td colspan="3">♦♦References: [6,11,12,19,21-23,121,123,129-131,135,140,143,146,147]</td></tr><tr><td></td><td></td><td></td></tr><tr><td>n</td><td>% difference</td><td>p-value</td></tr><tr><td>9</td><td>-</td><td>-</td></tr><tr><td>93</td><td>12</td><td>0.0009</td></tr><tr><td>54</td><td>7</td><td>0.004</td></tr><tr><td>46</td><td>12</td><td>0.27</td></tr><tr><td>46</td><td>-</td><td>-</td></tr><tr><td>46</td><td>-</td><td>-</td></tr><tr><td>-</td><td>-</td><td>-</td></tr><tr><td colspan="3">♦♦♦References: [140,141,143,147].</td></tr></table>
5a7bc6f302926549eef460dd87f34cbaff2844a02257c6a50e36153e102c229c.png
simple
<table><tr><td>Library</td><td>Restriction enzyme</td><td>BAC vector</td><td>No. clones</td><td>Average insert size (kb)</td><td>Insert range (kb)</td><td>Genome coverage*</td><td>HICF fragments (avg)</td><td>Control clones</td><td>Successful fingerprints</td></tr><tr><td>TC_Bba</td><td>HindIII</td><td>pIndigoBAC536</td><td>36864</td><td>145</td><td>90-185</td><td>10&#215;</td><td>120.2</td><td>768</td><td>31864</td></tr><tr><td>TC_BBb</td><td>EcoRI</td><td>pIndigoBAC536</td><td>36864</td><td>120</td><td>40-160</td><td>10&#215;</td><td>102.1</td><td>768</td><td>32218</td></tr><tr><td>TC_BBc</td><td>MboI</td><td>pIndigoBAC536</td><td>36864</td><td>140</td><td>80-180</td><td>10&#215;</td><td>120.4</td><td>768</td><td>31304</td></tr></table>
<table><tr><td>Library</td><td>Restriction enzyme</td><td>BAC vector</td><td>No. clones</td><td>Average insert size (kb)</td><td>Insert range (kb)</td><td>Genome coverage*</td><td>HICF fragments (avg)</td></tr><tr><td>TC_Bba</td><td>HindIII</td><td>pIndigoBAC536</td><td>36864</td><td>145</td><td>90-185</td><td>10×</td><td>120.2</td></tr><tr><td>TC_BBb</td><td>EcoRI</td><td>pIndigoBAC536</td><td>36864</td><td>120</td><td>40-160</td><td>10×</td><td>102.1</td></tr><tr><td>TC_BBc</td><td>MboI</td><td>pIndigoBAC536</td><td>36864</td><td>140</td><td>80-180</td><td>10×</td><td>120.4</td></tr></table>
<table><tr><td>Control clones</td><td>Successful fingerprints</td></tr><tr><td>768</td><td>31864</td></tr><tr><td>768</td><td>32218</td></tr><tr><td>768</td><td>31304</td></tr></table>
5abafd2fa161e4ce9a054d3c931f087fb593c9cf0cf338720dfb550954a6c1a6.png
simple
<table><tr><td>Parameter</td><td>Value</td></tr><tr><td>Self-inductance</td><td><i>L</i> = 6 [mH]</td></tr><tr><td>Rated current</td><td><i>I</i> = 8 [A] (AC, 50/60 Hz, sinus wave)</td></tr><tr><td>Current density</td><td><i>J</i> &lt; 3 [A/mm<sup>2</sup>]</td></tr><tr><td>Ambient temperature</td><td><i>&#952;</i><sub>a</sub> = +40 [&#176;C]</td></tr><tr><td>Self-resonance frequency range</td><td><i>f</i><sub>crit</sub> = 80 &#247; 140 [kHz]</td></tr></table>
<table><tr><td>Parameter</td><td>Value</td></tr></table>
<table><tr><td>Self-inductance</td><td>L = 6 [mH]</td></tr><tr><td>Rated current</td><td>I = 8 [A] (AC, 50/60 Hz, sinus wave)</td></tr><tr><td>Current density</td><td>J < 3 [A/mm2]</td></tr><tr><td>Ambient temperature</td><td>θa = +40 [°C]</td></tr><tr><td>Self-resonance frequency range</td><td>fcrit = 80 ÷ 140 [kHz]</td></tr></table>
a841029d5381d0f065c42ee370d7bd0d613b2363bd2bfb17df96154f01506dc8.png
complex
<table><tr><td>Variable</td><td>OR</td><td>95 % CI</td><td><i>P</i>-value</td></tr><tr><td colspan="4">Clinical history</td></tr><tr><td> No recent history of UTI</td><td>3.8</td><td>1.3&#8211;11.4</td><td>0.02</td></tr><tr><td colspan="4">Clinical symptoms</td></tr><tr><td> Nausea/vomiting</td><td>0.4</td><td>0.1&#8211;1.4</td><td>0.14</td></tr><tr><td colspan="4">Type of UTI, symptoms</td></tr><tr><td> Cystitis, no other non-urinary symptoms</td><td>1</td><td></td><td></td></tr><tr><td> Cystitis, with back or adnominal pain symptoms only</td><td>11.4</td><td>2.1&#8211;63.0</td><td>0.01</td></tr><tr><td> Cystitis, with vaginal discharge</td><td>12.1</td><td>1.1&#8211;137.5</td><td>0.05</td></tr><tr><td> Cystitis, with other combinations of non-urinary symptoms</td><td>0.1</td><td>0.0&#8211;1.1</td><td>0.06</td></tr><tr><td> Pyelonephritis (fever or flank pain present)</td><td>2.7</td><td>0.8&#8211;9.3</td><td>0.12</td></tr></table>
<table><tr><td>Variable</td><td>OR</td><td>95 % CI</td><td>P-value</td></tr><tr><td colspan="4">Clinical history</td></tr><tr><td>No recent history of UTI</td><td>3.8</td><td>1.3–11.4</td><td>0.02</td></tr><tr><td colspan="4">Clinical symptoms</td></tr></table>
<table><tr><td>Variable</td><td>OR</td><td>95 % CI</td><td>P-value</td></tr><tr><td>Nausea/vomiting</td><td>0.4</td><td>0.1–1.4</td><td>0.14</td></tr><tr><td colspan="4">Type of UTI, symptoms</td></tr><tr><td>Cystitis, no other non-urinary symptoms</td><td>1</td><td></td><td></td></tr><tr><td>Cystitis, with back or adnominal pain symptoms only</td><td>11.4</td><td>2.1–63.0</td><td>0.01</td></tr><tr><td>Cystitis, with vaginal discharge</td><td>12.1</td><td>1.1–137.5</td><td>0.05</td></tr><tr><td>Cystitis, with other combinations of non-urinary symptoms</td><td>0.1</td><td>0.0–1.1</td><td>0.06</td></tr><tr><td>Pyelonephritis (fever or flank pain present)</td><td>2.7</td><td>0.8–9.3</td><td>0.12</td></tr></table>
f9da33b661cacb5aafb5e057630e408d8d14fdb35047ed7d16a365ae334c7ed3.png
simple
<table><tr><td>Characteristics</td><td>n (%)</td></tr><tr><td>Knowledge of modifiable risk factors</td><td></td></tr><tr><td> Don't know any risk factor</td><td>27 (3.8)</td></tr><tr><td> Only one risk factor</td><td>89 (12.4)</td></tr><tr><td> A total of two risk factors</td><td>302 (41.9)</td></tr><tr><td> Good level of knowledge*</td><td>302 (41.9)</td></tr><tr><td>Knowledge of symptoms of heart attack</td><td></td></tr><tr><td> Don't Know</td><td>586 (81.4)</td></tr><tr><td> List 1 symptom</td><td>93 (12.9)</td></tr><tr><td> List at least 2 symptoms</td><td>41 (5.7)</td></tr></table>
<table><tr><td>Characteristics</td><td>n (%)</td></tr><tr><td>Knowledge of modifiable risk factors</td><td></td></tr><tr><td>Don't know any risk factor</td><td>27 (3.8)</td></tr><tr><td>Only one risk factor</td><td>89 (12.4)</td></tr><tr><td>A total of two risk factors</td><td>302 (41.9)</td></tr></table>
<table><tr><td>Good level of knowledge*</td><td>302 (41.9)</td></tr><tr><td>Knowledge of symptoms of heart attack</td><td></td></tr><tr><td>Don't Know</td><td>586 (81.4)</td></tr><tr><td>List 1 symptom</td><td>93 (12.9)</td></tr><tr><td>List at least 2 symptoms</td><td>41 (5.7)</td></tr></table>
46a3a6d1eeabef9df20071538a6b54a0ecf486641e964510dbb586c036984517.png
simple
<table><tr><td><i>&#955;</i></td><td>0.0</td><td>0.1</td><td>0.2</td><td>0.3</td><td>0.4</td><td>0.5</td></tr><tr><td>AUC</td><td>0.916</td><td>0.919</td><td>0.920</td><td>0.922</td><td>0.919</td><td>0.918</td></tr></table>
<table><tr><td>λ</td><td>0.0</td><td>0.1</td></tr><tr><td>AUC</td><td>0.916</td><td>0.919</td></tr></table>
<table><tr><td>0.2</td><td>0.3</td><td>0.4</td><td>0.5</td></tr><tr><td>0.920</td><td>0.922</td><td>0.919</td><td>0.918</td></tr></table>
4675037257ce8cdf546f60fb1ecf741b628f1cfa2ce249a6b406ab60aeac585c.png
complex
<table><tr><td> </td><td> </td><td colspan="2">Univariate analysis</td><td colspan="3">Multivariate analysis</td></tr><tr><td>Variable</td><td>Threshold</td><td>Unadjusted OR</td><td>CI</td><td>Adjusted OR</td><td>CI</td><td><i>P </i>value</td></tr><tr><td>Glucose variability (SD)</td><td>NA</td><td>5.9</td><td>0.9 to 37</td><td>10.4</td><td>1.3 to 86</td><td>.03</td></tr><tr><td>GCS</td><td>Every 1 point</td><td>1.1</td><td>0.8 to 1.4</td><td>0.5</td><td>0.2 to 0.99</td><td>.04</td></tr></table>
<table><tr><td></td><td></td><td colspan="2">Univariate analysis</td><td colspan="2">Multivariate analysis</td></tr><tr><td>Variable</td><td>Threshold</td><td>Unadjusted OR</td><td>CI</td><td>Adjusted OR</td><td>CI</td></tr><tr><td>Glucose variability (SD)</td><td>NA</td><td>5.9</td><td>0.9 to 37</td><td>10.4</td><td>1.3 to 86</td></tr><tr><td>GCS</td><td>Every 1 point</td><td>1.1</td><td>0.8 to 1.4</td><td>0.5</td><td>0.2 to 0.99</td></tr></table>
<table><tr><td>Multivariate analysis</td></tr><tr><td>P value</td></tr><tr><td>.03</td></tr><tr><td>.04</td></tr></table>
b90366b98a85360301989d2ba2feadd9b76366afdcfd8e817458f281678b3802.png
simple
<table><tr><td>Group</td><td>n</td><td>Clinical pregnancy (case), %</td><td>Abortion (case)</td><td>Multiple pregnancy (case)</td><td>Average treatment cycle</td></tr><tr><td>LE group</td><td>52</td><td>16 (30.8%)</td><td>2</td><td>2</td><td>4.1&#177;0.5</td></tr><tr><td>CC group</td><td>52</td><td>17 (32.1%)</td><td>3</td><td>3</td><td>3.9&#177;0.2</td></tr><tr><td>LE + HMG group</td><td>52</td><td>29 (55.7%)<sup>a</sup></td><td>2</td><td>5</td><td>2.9 &#177; 0.3<sup>b</sup></td></tr><tr><td>&#967;<sup>2</sup>/F</td><td>-</td><td>-</td><td>-</td><td>-</td><td>17.241</td></tr><tr><td>P</td><td>-</td><td>-</td><td>-</td><td>-</td><td>&lt;0.001</td></tr></table>
<table><tr><td>Group</td><td>n</td><td>Clinical pregnancy (case), %</td><td>Abortion (case)</td><td>Multiple pregnancy (case)</td><td>Average treatment cycle</td></tr><tr><td>LE group</td><td>52</td><td>16 (30.8%)</td><td>2</td><td>2</td><td>4.1±0.5</td></tr><tr><td>CC group</td><td>52</td><td>17 (32.1%)</td><td>3</td><td>3</td><td>3.9±0.2</td></tr></table>
<table><tr><td>Group</td><td>n</td><td>Clinical pregnancy (case), %</td><td>Abortion (case)</td><td>Multiple pregnancy (case)</td><td>Average treatment cycle</td></tr><tr><td>LE + HMG group</td><td>52</td><td>29 (55.7%)a</td><td>2</td><td>5</td><td>2.9 ± 0.3b</td></tr><tr><td>χ2/F</td><td>-</td><td>-</td><td>-</td><td>-</td><td>17.241</td></tr><tr><td>P</td><td>-</td><td>-</td><td>-</td><td>-</td><td><0.001</td></tr></table>
a936a76f282dc09eda107f2d27f8de4f7a531276a73e79c05971362c3461aa22.png
complex
<table><tr><td></td><td colspan="2">Data sources</td><td colspan="2">Health care organization characteristics</td></tr><tr><td>Country</td><td>Revenue/income</td><td>Practice costs</td><td>Remuneration system</td><td>Gate-keeping</td></tr><tr><td>Belgium</td><td>Interest group</td><td>Interest group</td><td>Fee-for-service</td><td>No</td></tr><tr><td>Denmark</td><td>Interest group and government agency</td><td>Interest group and government agency</td><td>Fee-for-service</td><td>Yes</td></tr><tr><td>Finland</td><td>WHO (2000) and independent organization</td><td>-</td><td>Mainly salary, some additional fee-for-service and capitation fee</td><td>Yes</td></tr><tr><td>France</td><td>Government agency</td><td>Tax office</td><td>Fee-for-service</td><td>No</td></tr><tr><td>Germany</td><td>Independent organization</td><td>Independent organization</td><td>Fee-for-service</td><td>No</td></tr><tr><td>Netherlands</td><td>Interest group</td><td>National statistics office (based on tax data)</td><td>Capitation and fee-for-service<sup>1)</sup></td><td>Yes</td></tr><tr><td>Sweden</td><td>Interest group</td><td>-</td><td>Salary</td><td>No</td></tr><tr><td>U.K.</td><td>Independent organization (1995, 2000), government agency (2005)</td><td>Independent organization (1995, 2000), government agency (2005)</td><td>Capitation, since 2004 additional quality related payments</td><td>Yes</td></tr></table>
<table><tr><td></td><td colspan="2">Data sources</td><td colspan="2">Health care organization characteristics</td></tr><tr><td>Coun</td><td>Revenue/income</td><td>Pr</td><td>Remuneratio</td><td>Gate-</td></tr></table>
<table><tr><td>try</td><td></td><td>actice costs</td><td>n system</td><td>keeping</td></tr><tr><td>Belgium</td><td>Interest group</td><td>Interest group</td><td>Fee-for-service</td><td>No</td></tr><tr><td>Denmark</td><td>Interest group and government agency</td><td>Interest group and government agency</td><td>Fee-for-service</td><td>Yes</td></tr><tr><td>Finland</td><td>WHO (2000) and independent organization</td><td>-</td><td>Mainly salary, some additional fee-for-service and capitation fee</td><td>Yes</td></tr><tr><td>France</td><td>Government agency</td><td>Tax office</td><td>Fee-for-service</td><td>No</td></tr><tr><td>Germany</td><td>Independent organization</td><td>Independent organization</td><td>Fee-for-service</td><td>No</td></tr><tr><td>Netherlands</td><td>Interest group</td><td>National statistics office (based on tax data)</td><td>Capitation and fee-for-service1)</td><td>Yes</td></tr><tr><td>Sweden</td><td>Interest group</td><td>-</td><td>Salary</td><td>No</td></tr><tr><td>U.K.</td><td>Independent organization (1995, 2000), government agency (2005)</td><td>Independent organization (1995, 2000), government agency (2005)</td><td>Capitation, since 2004 additional quality related payments</td><td>Yes</td></tr></table>
1915a971b0c8d44abeba0341d8b3559046ba0cd1fb46f65e5e5dafd4ea177510.png
complex
<table><tr><td>PatID</td><td colspan="2">MWRT (sec; average + std)</td><td colspan="2">Percentage of 6-s time windows with difference in MWRT:</td></tr><tr><td> </td><td>Signal 1</td><td>Signal 2</td><td><underline>&gt;</underline>0.1 s</td><td><underline>&gt;</underline>0.2 s</td></tr><tr><td colspan="5">Category A</td></tr><tr><td>1</td><td>0.27 + 0.04</td><td>0.27 + 0.04</td><td>-</td><td>-</td></tr><tr><td>2</td><td>0.21 + 0.02</td><td>0.21 + 0.02</td><td>-</td><td>-</td></tr><tr><td>3</td><td>0.14 + 0.04</td><td>0.14 + 0.03</td><td>1</td><td>-</td></tr><tr><td>4</td><td>0.18 + 0.05</td><td>0.18 + 0.05</td><td>-</td><td>-</td></tr><tr><td>5</td><td>0.28 + 0.06</td><td>0.28 + 0.05</td><td>-</td><td>-</td></tr><tr><td colspan="5">Category B</td></tr><tr><td>6</td><td>0.29 + 0.04</td><td>0.24 + 0.04</td><td>13</td><td>-</td></tr><tr><td>7</td><td>0.25 + 0.02</td><td>0.25 + 0.04</td><td>2</td><td>-</td></tr><tr><td>8</td><td>0.23 + 0.02</td><td>0.21 + 0.03</td><td>2</td><td>-</td></tr><tr><td>9</td><td>0.14 + 0.04</td><td>0.14 + 0.04</td><td>3</td><td>1</td></tr><tr><td>10</td><td>0.28 + 0.03</td><td>0.24 + 0.06</td><td>14</td><td>-</td></tr><tr><td colspan="5">Category C</td></tr><tr><td>11</td><td>0.26 + 0.05</td><td>0.28 + 0.02</td><td>9</td><td>-</td></tr><tr><td>12</td><td>0.33 + 0.13</td><td>0.23 + 0.09</td><td>45</td><td>17</td></tr><tr><td>13</td><td>0.36 + 0.06</td><td>0.45 + 0.12</td><td>50</td><td>20</td></tr><tr><td>14</td><td>0.33 + 0.09</td><td>0.39 + 0.10</td><td>25</td><td>7</td></tr><tr><td>15</td><td>0.22 + 14.3</td><td>0.22 + 14.3</td><td>8</td><td>1</td></tr><tr><td>16</td><td>0.12 + 0.01</td><td>0.12 + 0.01</td><td>-</td><td>-</td></tr><tr><td>17</td><td>0.24 + 0.05</td><td>0.25 + 0.03</td><td>7</td><td>-</td></tr></table>
<table><tr><td>PatID</td><td colspan="2">MWRT (sec; average + std)</td><td colspan="2">Percentage of 6-s time windows with difference in MWRT:</td></tr><tr><td></td><td>Signal 1</td><td>Signal 2</td><td>>0.1 s</td><td>>0.2 s</td></tr><tr><td colspan="5">Category A</td></tr></table>
<table><tr><td>1</td><td>0.27 + 0.04</td><td>0.27 + 0.04</td><td>-</td><td>-</td></tr><tr><td>2</td><td>0.21 + 0.02</td><td>0.21 + 0.02</td><td>-</td><td>-</td></tr><tr><td>3</td><td>0.14 + 0.04</td><td>0.14 + 0.03</td><td>1</td><td>-</td></tr><tr><td>4</td><td>0.18 + 0.05</td><td>0.18 + 0.05</td><td>-</td><td>-</td></tr><tr><td>5</td><td>0.28 + 0.06</td><td>0.28 + 0.05</td><td>-</td><td>-</td></tr><tr><td colspan="5">Category B</td></tr><tr><td>6</td><td>0.29 + 0.04</td><td>0.24 + 0.04</td><td>13</td><td>-</td></tr><tr><td>7</td><td>0.25 + 0.02</td><td>0.25 + 0.04</td><td>2</td><td>-</td></tr><tr><td>8</td><td>0.23 + 0.02</td><td>0.21 + 0.03</td><td>2</td><td>-</td></tr><tr><td>9</td><td>0.14 + 0.04</td><td>0.14 + 0.04</td><td>3</td><td>1</td></tr><tr><td>10</td><td>0.28 + 0.03</td><td>0.24 + 0.06</td><td>14</td><td>-</td></tr><tr><td colspan="5">Category C</td></tr><tr><td>11</td><td>0.26 + 0.05</td><td>0.28 + 0.02</td><td>9</td><td>-</td></tr><tr><td>12</td><td>0.33 + 0.13</td><td>0.23 + 0.09</td><td>45</td><td>17</td></tr><tr><td>13</td><td>0.36 + 0.06</td><td>0.45 + 0.12</td><td>50</td><td>20</td></tr><tr><td>14</td><td>0.33 + 0.09</td><td>0.39 + 0.10</td><td>25</td><td>7</td></tr><tr><td>15</td><td>0.22 + 14.3</td><td>0.22 + 14.3</td><td>8</td><td>1</td></tr><tr><td>16</td><td>0.12 + 0.01</td><td>0.12 + 0.01</td><td>-</td><td>-</td></tr><tr><td>17</td><td>0.24 + 0.05</td><td>0.25 + 0.03</td><td>7</td><td>-</td></tr></table>
683338bcb742b0722e770aff8a266adcb9a62815d2aa7a124304c960ba40fd3d.png
complex
<table><tr><td></td><td colspan="3">COPD</td><td colspan="3">Non-COPD</td></tr><tr><td>Variable</td><td>Effect</td><td>CI 95 %</td><td><i>p</i></td><td>Effect</td><td>CI 95 %</td><td><i>p</i></td></tr><tr><td>Time trends (years)</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> 2000&#8211;2005</td><td>0.56</td><td>&#8722;0.11; 1.23</td><td>0.102</td><td>0.35</td><td>0.25; 0.46</td><td>&lt;0.001</td></tr><tr><td> 2005&#8211;2010</td><td>0.62</td><td>&#8722;0.22; 1.26</td><td>0.059</td><td>0.39</td><td>0.29; 0.49</td><td>&lt;0.001</td></tr><tr><td> 2000&#8211;2010</td><td>1.18</td><td>0.52; 1.84</td><td>&lt;0.001</td><td>0.74</td><td>0.63; 0.86</td><td>&lt;0.001</td></tr><tr><td> Age (years)</td><td>&#8722;0.06</td><td>&#8722;0.08; &#8722;0.04</td><td>&lt;0.001</td><td>0.01</td><td>0.004; 0.01</td><td>&lt;0.001</td></tr><tr><td> Current smoker</td><td>&#8722;1.87</td><td>&#8722;2.42; &#8722;1.32</td><td>&lt;0.001</td><td>&#8722;0.98</td><td>&#8722;1.08; &#8722;0.88</td><td>&lt;0.001</td></tr><tr><td> Exceeding alcohol limits</td><td>0.04</td><td>&#8722;0.69; 0.77</td><td>0.919</td><td>0.00</td><td>&#8722;0.13; 0.14</td><td>0.969</td></tr><tr><td> Physical activity</td><td>0.93</td><td>0.34;1.53</td><td>0.002</td><td>0.98</td><td>0.85;1.11</td><td>&lt;0.001</td></tr><tr><td> Married/living with a partner</td><td>0.13</td><td>&#8722;0.44; 0.69</td><td>0.661</td><td>0.34</td><td>0,23; 0.44</td><td>&lt;0.001</td></tr><tr><td> Gender (male)</td><td>1.68</td><td>1.13; 2.23</td><td>&lt;0.001</td><td>1.38</td><td>1.29; 1.47</td><td>&lt;0.001</td></tr><tr><td colspan="7">Education (years)</td></tr><tr><td>&lt; 10 vs. 10-12</td><td>0.72</td><td>0.14; 1.31</td><td>0.015</td><td>0.72</td><td>0.60; 0.84</td><td>&lt;0.001</td></tr><tr><td>&lt; 10 vs. +13</td><td>0.99</td><td>0.09; 1.88</td><td>0.030</td><td>1.63</td><td>1.49; 1.77</td><td>&lt;0.001</td></tr><tr><td> 10-12 vs. +13</td><td>0.27</td><td>&#8722;0.58; 1.11</td><td>0.536</td><td>0.92</td><td>0.81; 1.02</td><td>&lt;0.001</td></tr></table>
<table><tr><td></td><td colspan="3">COPD</td><td colspan="3">Non-COPD</td></tr><tr><td>Variable</td><td>Effect</td><td>CI 95 %</td><td>p</td><td>Effect</td><td>CI 95 %</td><td>p</td></tr><tr><td>Time trends (years)</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>2000–2005</td><td>0.56</td><td>−0.11; 1.23</td><td>0.102</td><td>0.35</td><td>0.25; 0.46</td><td><0.001</td></tr><tr><td>2005–2010</td><td>0.62</td><td>−0.22; 1.26</td><td>0.059</td><td>0.39</td><td>0.29; 0.49</td><td><0.001</td></tr><tr><td>2000–2010</td><td>1.18</td><td>0.52; 1.84</td><td><0.001</td><td>0.74</td><td>0.63; 0.86</td><td><0.001</td></tr><tr><td>Age (years)</td><td>−0.06</td><td>−0.08; −0.04</td><td><0.001</td><td>0.01</td><td>0.004; 0.01</td><td><0.001</td></tr><tr><td>Current smoker</td><td>−1.87</td><td>−2.42; −1.32</td><td><0.001</td><td>−0.98</td><td>−1.08; −0.88</td><td><0.001</td></tr><tr><td>Exceeding alcohol limits</td><td>0.04</td><td>−0.69; 0.77</td><td>0.919</td><td>0.00</td><td>−0.13; 0.14</td><td>0.969</td></tr><tr><td>Physical activity</td><td>0.93</td><td>0.34;1.53</td><td>0.002</td><td>0.98</td><td>0.85;1.11</td><td><0.001</td></tr><tr><td>Married/living with a partner</td><td>0.13</td><td>−0.44; 0.69</td><td>0.661</td><td>0.34</td><td>0,23; 0.44</td><td><0.001</td></tr><tr><td>Gender (male)</td><td>1.68</td><td>1.13; 2.23</td><td><0.001</td><td>1.38</td><td>1.29; 1.47</td><td><0.001</td></tr></table>
<table><tr><td colspan="7">Education (years)</td></tr><tr><td>< 10 vs. 10-12</td><td>0.72</td><td>0.14; 1.31</td><td>0.015</td><td>0.72</td><td>0.60; 0.84</td><td><0.001</td></tr><tr><td>< 10 vs. +13</td><td>0.99</td><td>0.09; 1.88</td><td>0.030</td><td>1.63</td><td>1.49; 1.77</td><td><0.001</td></tr><tr><td>10-12 vs. +13</td><td>0.27</td><td>−0.58; 1.11</td><td>0.536</td><td>0.92</td><td>0.81; 1.02</td><td><0.001</td></tr></table>
65159075745d8e1105966ab37de7593ea65da00a897391ffb67f695216571924.png
complex
<table><tr><td></td><td colspan="2">WOMEN</td><td colspan="2">MEN</td></tr><tr><td></td><td>Core</td><td>Boost</td><td>Core</td><td>Boost</td></tr><tr><td></td><td>%</td><td>%</td><td>%</td><td>%</td></tr><tr><td>Self-assessed general health</td><td></td><td></td><td></td><td></td></tr><tr><td>Very good</td><td>33</td><td>21</td><td>36</td><td>24</td></tr><tr><td>Good</td><td>45</td><td>51</td><td>44</td><td>48</td></tr><tr><td>Fair</td><td>14</td><td>23</td><td>14</td><td>24</td></tr><tr><td>Bad</td><td>6</td><td>4</td><td>5</td><td>3</td></tr><tr><td>Very bad</td><td>2</td><td>1</td><td>1</td><td>1</td></tr><tr><td><i>P-value</i></td><td></td><td><i><underline>0.000</underline></i></td><td></td><td><i><underline>0.000</underline></i></td></tr><tr><td>Very good/good</td><td>78</td><td>72</td><td>79</td><td>72</td></tr><tr><td>Fair/bad/very bad</td><td>22</td><td>28</td><td>21</td><td>28</td></tr><tr><td><i>P-value</i></td><td></td><td><i><underline>0.000</underline></i></td><td></td><td><i><underline>0.000</underline></i></td></tr><tr><td>N</td><td>833</td><td>2701</td><td>736</td><td>2181</td></tr><tr><td>Portions of fruit and vegetables</td><td></td><td></td><td></td><td></td></tr><tr><td> Less than 1</td><td>5</td><td>4</td><td>8</td><td>6</td></tr><tr><td> 1 to 2</td><td>26</td><td>15</td><td>26</td><td>17</td></tr><tr><td> 3 to 4</td><td>27</td><td>27</td><td>28</td><td>24</td></tr><tr><td> 5 or more</td><td>42</td><td>55</td><td>38</td><td>54</td></tr><tr><td><i>P-value</i></td><td></td><td><i><underline>0.000</underline></i></td><td></td><td><i><underline>0.000</underline></i></td></tr><tr><td>N</td><td>833</td><td>2647</td><td>735</td><td>2133</td></tr></table>
<table><tr><td></td><td colspan="2">WOMEN</td></tr><tr><td></td><td>Core</td><td>Boost</td></tr><tr><td></td><td>%</td><td>%</td></tr><tr><td>Self-assessed general health</td><td></td><td></td></tr><tr><td>Very good</td><td>33</td><td>21</td></tr><tr><td>Good</td><td>45</td><td>51</td></tr><tr><td>Fair</td><td>14</td><td>23</td></tr><tr><td>Bad</td><td>6</td><td>4</td></tr><tr><td>Very bad</td><td>2</td><td>1</td></tr><tr><td>P-value</td><td></td><td>0.000</td></tr><tr><td>Very good/good</td><td>78</td><td>72</td></tr><tr><td>Fair/bad/very bad</td><td>22</td><td>28</td></tr><tr><td>P-value</td><td></td><td>0.000</td></tr><tr><td>N</td><td>833</td><td>2701</td></tr><tr><td>Portions of fruit and vegetables</td><td></td><td></td></tr><tr><td>Less than 1</td><td>5</td><td>4</td></tr><tr><td>1 to 2</td><td>26</td><td>15</td></tr><tr><td>3 to 4</td><td>27</td><td>27</td></tr><tr><td>5 or more</td><td>42</td><td>55</td></tr><tr><td>P-value</td><td></td><td>0.000</td></tr><tr><td>N</td><td>833</td><td>2647</td></tr></table>
<table><tr><td colspan="2">MEN</td></tr><tr><td>Core</td><td>Boost</td></tr><tr><td>%</td><td>%</td></tr><tr><td></td><td></td></tr><tr><td>36</td><td>24</td></tr><tr><td>44</td><td>48</td></tr><tr><td>14</td><td>24</td></tr><tr><td>5</td><td>3</td></tr><tr><td>1</td><td>1</td></tr><tr><td></td><td>0.000</td></tr><tr><td>79</td><td>72</td></tr><tr><td>21</td><td>28</td></tr><tr><td></td><td>0.000</td></tr><tr><td>736</td><td>2181</td></tr><tr><td></td><td></td></tr><tr><td>8</td><td>6</td></tr><tr><td>26</td><td>17</td></tr><tr><td>28</td><td>24</td></tr><tr><td>38</td><td>54</td></tr><tr><td></td><td>0.000</td></tr><tr><td>735</td><td>2133</td></tr></table>
7986af567fbfcd50bb4d709fb38c9e639c52ae281954a984562a976539614133.png
simple
<table><tr><td>Tissue</td><td>RNA expression</td><td>Tissue</td><td>RNA expression</td></tr><tr><td>Whole brain</td><td>&#8226;</td><td>Lung</td><td>&#8226;</td></tr><tr><td>Cerebral cortex</td><td>&#8226;&#8226;&#8226;</td><td>Placenta</td><td>&#8226;</td></tr><tr><td>Frontal lobe</td><td>&#8226;&#8226;</td><td>Bladder</td><td>&#8226;&#8226;</td></tr><tr><td>Parietal lobe</td><td>&#8226;&#8226;</td><td>Uterus</td><td>&#8226;&#8226;</td></tr><tr><td>Occipital lobe</td><td>&#8226;</td><td>Prostate</td><td>&#8226;</td></tr><tr><td>Temporal lobe</td><td>&#8226;</td><td>Testis</td><td>&#8226;</td></tr><tr><td>Postcentral gyrus</td><td>&#8226;</td><td>Ovary</td><td>&#8226;</td></tr><tr><td>of cerebral cortex</td><td></td><td>Liver</td><td>&#8226;</td></tr><tr><td>Pons</td><td>&#8226;</td><td>Pancreas</td><td>&#8226;&#8226;&#8226;</td></tr><tr><td>Cerebellum left</td><td>&#8226;</td><td>Adrenal gland</td><td>&#8226;&#8226;&#8226;</td></tr><tr><td>Cerebellum right</td><td>&#8226;&#8226;</td><td>Thyroid gland</td><td>&#8226;&#8226;</td></tr><tr><td>Corpus callosum</td><td>&#8226;&#8226;&#8226;</td><td>Salivary gland</td><td>&#8226;&#8226;&#8226;&#8226;</td></tr><tr><td>Amygdala</td><td>&#8226;&#8226;</td><td>Mammary gland</td><td>&#8226;</td></tr><tr><td>Caudate nucleus</td><td>&#8226;</td><td>Esophagus</td><td>&#8226;</td></tr><tr><td>Hippocampus</td><td>&#8226;</td><td>Stomach</td><td>&#8226;</td></tr><tr><td>Medulla</td><td>&#8226;</td><td>Duodenum</td><td>&#8226;&#8226;</td></tr><tr><td>oblongata</td><td></td><td>Jejunum</td><td>&#8226;&#8226;&#8226;</td></tr><tr><td>Putamen</td><td>&#8226;</td><td>Ileum</td><td>&#8226;&#8226;</td></tr><tr><td>Substantia nigra</td><td>&#8226;</td><td>Ileocecum</td><td>&#8226;</td></tr><tr><td>Accumbens</td><td>&#8226;&#8226;</td><td>Appendix</td><td>-</td></tr><tr><td>nucleus</td><td></td><td>Colon, ascending</td><td>&#8226;</td></tr><tr><td>Thalamus</td><td>&#8226;&#8226;</td><td>Colon, transverse</td><td>&#8226;</td></tr><tr><td>Pituary gland</td><td>&#8226;</td><td>Colon, descending</td><td>&#8226;</td></tr><tr><td>Spinal cord</td><td>&#8226;</td><td>Rectum</td><td>&#8226;</td></tr><tr><td>Heart</td><td>&#8226;&#8226;</td><td>Fetal brain</td><td>&#8226;</td></tr><tr><td>Aorta</td><td>&#8226;</td><td>Fetal heart</td><td>&#8226;&#8226;</td></tr><tr><td>Artrium left</td><td>&#8226;&#8226;</td><td>Fetal kidney</td><td>&#8226;&#8226;&#8226;</td></tr><tr><td>Artrium right</td><td>&#8226;&#8226;</td><td>Fetal liver</td><td>&#8226;&#8226;&#8226;</td></tr><tr><td>Ventricle left</td><td>&#8226;&#8226;&#8226;&#8226;</td><td>Fetal spleen</td><td>&#8226;</td></tr><tr><td>Ventricle right</td><td>&#8226;&#8226;</td><td>Fetal thymus</td><td>&#8226;</td></tr><tr><td>Interventricular</td><td>&#8226;&#8226;</td><td>Fetal lung</td><td>&#8226;</td></tr><tr><td>septum</td><td></td><td>Promyelocytic leukaemia,</td><td>&#8226;</td></tr><tr><td>Apex of the heart</td><td>&#8226;&#8226;&#8226;&#8226;</td><td>HL-60</td><td></td></tr><tr><td>Kidney</td><td>&#8226;</td><td>Hela S3</td><td>&#8226;</td></tr><tr><td>Skeletal muscle</td><td>&#8226;</td><td>Chronic myelogenous</td><td>&#8226;&#8226;</td></tr><tr><td>Spleen</td><td>&#8226;</td><td>leukaemia, K-562</td><td></td></tr><tr><td>Thymus</td><td>&#8226;&#8226;</td><td>Lymphoblastic leukaemia,</td><td>&#8226;&#8226;</td></tr><tr><td>Peripheral blood</td><td>&#8226;</td><td>MOLT-4</td><td></td></tr><tr><td>leukocyte</td><td></td><td>Burkitt's lymphoma, Raji</td><td>&#8226;</td></tr><tr><td>Lymph node</td><td>&#8226;</td><td>Burkitt's lymphoma, Daudi</td><td>&#8226;</td></tr><tr><td>Trachea</td><td>&#8226;</td><td></td><td></td></tr></table>
<table><tr><td>Tissue</td><td>RNA expression</td></tr><tr><td>Whole brain</td><td>•</td></tr><tr><td>Cerebral cortex</td><td>•••</td></tr><tr><td>Frontal lobe</td><td>••</td></tr><tr><td>Parietal lobe</td><td>••</td></tr><tr><td>Occipital lobe</td><td>•</td></tr><tr><td>Temporal lobe</td><td>•</td></tr><tr><td>Postcentral gyrus</td><td>•</td></tr><tr><td>of cerebral cortex</td><td></td></tr><tr><td>Pons</td><td>•</td></tr><tr><td>Cerebellum left</td><td>•</td></tr><tr><td>Cerebellum right</td><td>••</td></tr><tr><td>Corpus callosum</td><td>•••</td></tr><tr><td>Amygdala</td><td>••</td></tr><tr><td>Caudate nucleus</td><td>•</td></tr><tr><td>Hippocampus</td><td>•</td></tr><tr><td>Medulla</td><td>•</td></tr><tr><td>oblongata</td><td></td></tr><tr><td>Putamen</td><td>•</td></tr><tr><td>Substantia nigra</td><td>•</td></tr><tr><td>Accumbens</td><td>••</td></tr><tr><td>nucleus</td><td></td></tr><tr><td>Thalamus</td><td>••</td></tr><tr><td>Pituary gland</td><td>•</td></tr><tr><td>Spinal cord</td><td>•</td></tr><tr><td>Heart</td><td>••</td></tr><tr><td>Aorta</td><td>•</td></tr><tr><td>Artrium left</td><td>••</td></tr><tr><td>Artrium right</td><td>••</td></tr><tr><td>Ventricle left</td><td>••••</td></tr><tr><td>Ventricle right</td><td>••</td></tr><tr><td>Interventricular</td><td>••</td></tr><tr><td>septum</td><td></td></tr><tr><td>Apex of the heart</td><td>••••</td></tr><tr><td>Kidney</td><td>•</td></tr><tr><td>Skeletal muscle</td><td>•</td></tr><tr><td>Spleen</td><td>•</td></tr><tr><td>Thymus</td><td>••</td></tr><tr><td>Peripheral blood</td><td>•</td></tr><tr><td>leukocyte</td><td></td></tr><tr><td>Lymph node</td><td>•</td></tr><tr><td>Trachea</td><td>•</td></tr></table>
<table><tr><td>Tissue</td><td>RNA expression</td></tr><tr><td>Lung</td><td>•</td></tr><tr><td>Placenta</td><td>•</td></tr><tr><td>Bladder</td><td>••</td></tr><tr><td>Uterus</td><td>••</td></tr><tr><td>Prostate</td><td>•</td></tr><tr><td>Testis</td><td>•</td></tr><tr><td>Ovary</td><td>•</td></tr><tr><td>Liver</td><td>•</td></tr><tr><td>Pancreas</td><td>•••</td></tr><tr><td>Adrenal gland</td><td>•••</td></tr><tr><td>Thyroid gland</td><td>••</td></tr><tr><td>Salivary gland</td><td>••••</td></tr><tr><td>Mammary gland</td><td>•</td></tr><tr><td>Esophagus</td><td>•</td></tr><tr><td>Stomach</td><td>•</td></tr><tr><td>Duodenum</td><td>••</td></tr><tr><td>Jejunum</td><td>•••</td></tr><tr><td>Ileum</td><td>••</td></tr><tr><td>Ileocecum</td><td>•</td></tr><tr><td>Appendix</td><td>-</td></tr><tr><td>Colon, ascending</td><td>•</td></tr><tr><td>Colon, transverse</td><td>•</td></tr><tr><td>Colon, descending</td><td>•</td></tr><tr><td>Rectum</td><td>•</td></tr><tr><td>Fetal brain</td><td>•</td></tr><tr><td>Fetal heart</td><td>••</td></tr><tr><td>Fetal kidney</td><td>•••</td></tr><tr><td>Fetal liver</td><td>•••</td></tr><tr><td>Fetal spleen</td><td>•</td></tr><tr><td>Fetal thymus</td><td>•</td></tr><tr><td>Fetal lung</td><td>•</td></tr><tr><td>Promyelocytic leukaemia,</td><td>•</td></tr><tr><td>HL-60</td><td></td></tr><tr><td>Hela S3</td><td>•</td></tr><tr><td>Chronic myelogenous</td><td>••</td></tr><tr><td>leukaemia, K-562</td><td></td></tr><tr><td>Lymphoblastic leukaemia,</td><td>••</td></tr><tr><td>MOLT-4</td><td></td></tr><tr><td>Burkitt's lymphoma, Raji</td><td>•</td></tr><tr><td>Burkitt's lymphoma, Daudi</td><td>•</td></tr><tr><td></td><td></td></tr></table>
d3d0346aeb93b1a2b4b309a0e0e15142153ba1f07cd23954422c19a3ec899496.png
complex
<table><tr><td></td><td colspan="4">Rank of correct class</td></tr><tr><td></td><td>1</td><td>2</td><td>3</td><td>4</td></tr><tr><td>Single-localized only</td><td>88.8<sup>a</sup></td><td>92.2</td><td>94.5</td><td>96.3</td></tr><tr><td>CYT-NUC: 1 correct</td><td>88.2<sup>a</sup></td><td>96.1</td><td>99.5</td><td>100.0</td></tr><tr><td>CYT-NUC: both correct</td><td></td><td>66.5<sup>a</sup></td><td>82.9</td><td>96.3</td></tr><tr><td>All multi-localized: 1 correct</td><td>81.9<sup>a</sup></td><td>92.0</td><td>96.1</td><td>97.4</td></tr><tr><td>All multi-localized: both correct</td><td></td><td>59.7<sup>a</sup></td><td>73.8</td><td>83.2</td></tr></table>
<table><tr><td></td><td colspan="4">Rank of correct class</td></tr><tr><td></td><td>1</td><td>2</td><td>3</td><td>4</td></tr><tr><td>Single-localized only</td><td>88.8a</td><td>92.2</td><td>94.5</td><td>96.3</td></tr><tr><td>CYT-NUC: 1 correct</td><td>88.2a</td><td>96.1</td><td>99.5</td><td>100.0</td></tr><tr><td>CYT-NUC: both correct</td><td></td><td>66.5a</td><td>82.9</td><td>96.3</td></tr><tr><td>All multi-localized: 1 correct</td><td>81.9a</td><td>92.0</td><td>96.1</td><td>97.4</td></tr></table>
<table><tr><td></td><td colspan="4">Rank of correct class</td></tr><tr><td></td><td>1</td><td>2</td><td>3</td><td>4</td></tr><tr><td>All multi-localized: both correct</td><td></td><td>59.7a</td><td>73.8</td><td>83.2</td></tr></table>
4ab8628329ad41b367b11f464023b0d21f9959867da1510f7b14c3b65a7e8c6d.png
complex
<table><tr><td>Group</td><td>Patient number</td><td>Age</td><td>Sex</td><td>CRP (mg/dl)</td><td>ESR (mm)</td><td colspan="3">Medicine</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td>PSL (mg/day)</td><td>DMARDs other than biologics</td><td>Biologics</td></tr><tr><td rowspan="8">RA</td><td>#1</td><td>62</td><td>F</td><td>0.05</td><td>46</td><td></td><td>MTX</td><td>ADA</td></tr><tr><td>#2</td><td>67</td><td>F</td><td>0.49</td><td>29</td><td></td><td>MTX</td><td></td></tr><tr><td>#3</td><td>43</td><td>F</td><td>0.2</td><td>26</td><td>2</td><td>MTX</td><td></td></tr><tr><td>#4</td><td>48</td><td>F</td><td>0.06</td><td>39</td><td></td><td></td><td></td></tr><tr><td>#5</td><td>42</td><td>F</td><td>0.3</td><td>15</td><td>16</td><td>MTX</td><td>GLM</td></tr><tr><td>#6</td><td>80</td><td>F</td><td>4.2</td><td>71</td><td></td><td>TCR, SASP, BUC</td><td></td></tr><tr><td>#7</td><td>76</td><td>M</td><td>5.9</td><td>111</td><td></td><td>MTX</td><td></td></tr><tr><td>#8</td><td>62</td><td>F</td><td>0.5</td><td>38</td><td></td><td></td><td></td></tr><tr><td rowspan="8">OA</td><td>#9</td><td>66</td><td>F</td><td>0.02</td><td>10</td><td colspan="3"></td></tr><tr><td>#10</td><td>72</td><td>F</td><td>0.42</td><td>28</td><td colspan="3"></td></tr><tr><td>#11</td><td>75</td><td>F</td><td>0.07</td><td>14</td><td colspan="3"></td></tr><tr><td>#12</td><td>74</td><td>F</td><td>0.1</td><td>40</td><td colspan="3"></td></tr><tr><td>#13</td><td>74</td><td>F</td><td>0.03</td><td>9</td><td colspan="3"></td></tr><tr><td>#14</td><td>71</td><td>F</td><td>0.02</td><td>14</td><td colspan="3"></td></tr><tr><td>#15</td><td>78</td><td>F</td><td>0.12</td><td>18</td><td colspan="3"></td></tr><tr><td>#16</td><td>81</td><td>F</td><td>0.03</td><td>18</td><td colspan="3"></td></tr></table>
<table><tr><td>Group</td><td>Patient number</td><td>Age</td><td>Sex</td><td>CRP (mg/dl)</td><td>ESR (mm)</td><td colspan="3">Medicine</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td>PSL (mg/day)</td><td>DMARDs other than biologics</td><td>Biologics</td></tr><tr><td rowspan="4">RA</td><td>#1</td><td>62</td><td>F</td><td>0.05</td><td>46</td><td></td><td>MTX</td><td>ADA</td></tr><tr><td>#2</td><td>67</td><td>F</td><td>0.49</td><td>29</td><td></td><td>MTX</td><td></td></tr><tr><td>#3</td><td>43</td><td>F</td><td>0.2</td><td>26</td><td>2</td><td>MTX</td><td></td></tr><tr><td>#4</td><td>4</td><td></td><td></td><td>39</td><td></td><td></td><td></td></tr></table>
<table><tr><td rowspan="5"></td><td></td><td>8</td><td>F</td><td>0.06</td><td></td><td></td><td></td><td></td></tr><tr><td>#5</td><td>42</td><td>F</td><td>0.3</td><td>15</td><td>16</td><td>MTX</td><td>GLM</td></tr><tr><td>#6</td><td>80</td><td>F</td><td>4.2</td><td>71</td><td></td><td>TCR, SASP, BUC</td><td></td></tr><tr><td>#7</td><td>76</td><td>M</td><td>5.9</td><td>111</td><td></td><td>MTX</td><td></td></tr><tr><td>#8</td><td>62</td><td>F</td><td>0.5</td><td>38</td><td></td><td></td><td></td></tr><tr><td rowspan="8">OA</td><td>#9</td><td>66</td><td>F</td><td>0.02</td><td>10</td><td colspan="3"></td></tr><tr><td>#10</td><td>72</td><td>F</td><td>0.42</td><td>28</td><td colspan="3"></td></tr><tr><td>#11</td><td>75</td><td>F</td><td>0.07</td><td>14</td><td colspan="3"></td></tr><tr><td>#12</td><td>74</td><td>F</td><td>0.1</td><td>40</td><td colspan="3"></td></tr><tr><td>#13</td><td>74</td><td>F</td><td>0.03</td><td>9</td><td colspan="3"></td></tr><tr><td>#14</td><td>71</td><td>F</td><td>0.02</td><td>14</td><td colspan="3"></td></tr><tr><td>#15</td><td>78</td><td>F</td><td>0.12</td><td>18</td><td colspan="3"></td></tr><tr><td>#16</td><td>81</td><td>F</td><td>0.03</td><td>18</td><td colspan="3"></td></tr></table>
13b189d0d0ef755d837260b58f0ff70259a1930777de8759c877ae148d46abcc.png
complex
<table><tr><td>Characteristics</td><td colspan="2">Matrilineal</td><td colspan="2">Patrilineal</td></tr><tr><td>Age (years)</td><td>M</td><td>F</td><td>M</td><td>F</td></tr><tr><td> Mean</td><td>41</td><td>31</td><td>40</td><td>29</td></tr><tr><td> 20&#8211;29</td><td>0</td><td>2</td><td>0</td><td>3</td></tr><tr><td> 30&#8211;39</td><td>3</td><td>5</td><td>3</td><td>4</td></tr><tr><td> 40&#8211;49</td><td>4</td><td>0</td><td>4</td><td>0</td></tr><tr><td colspan="5">Years living with HIV</td></tr><tr><td> 1&#8211;5</td><td>2</td><td>2</td><td>7</td><td>7</td></tr><tr><td> 6&#8211;10</td><td>5</td><td>5</td><td>0</td><td>0</td></tr><tr><td>Average number of children couples had after an HIV diagnosis</td><td colspan="2">2</td><td colspan="2">1</td></tr><tr><td>Average number of children couples have in their households</td><td colspan="2">4</td><td colspan="2">4</td></tr><tr><td>Couples with HIV+ children</td><td colspan="2">2</td><td colspan="2">0</td></tr></table>
<table><tr><td>Characteristics</td><td colspan="2">Matrilineal</td><td colspan="2">Patrilineal</td></tr><tr><td>Age (years)</td><td>M</td><td>F</td><td>M</td><td>F</td></tr><tr><td>Mean</td><td>41</td><td>31</td><td>40</td><td>29</td></tr><tr><td>20–29</td><td>0</td><td>2</td><td>0</td><td>3</td></tr><tr><td>30–39</td><td>3</td><td>5</td><td>3</td><td>4</td></tr><tr><td>40–49</td><td>4</td><td>0</td><td>4</td><td>0</td></tr><tr><td colspan="5">Years living with HIV</td></tr><tr><td>1–5</td><td>2</td><td>2</td><td>7</td><td>7</td></tr><tr><td>6–10</td><td>5</td><td>5</td><td>0</td><td>0</td></tr><tr><td>Average number of children couples had after an HIV diagnosis</td><td colspan="2">2</td><td colspan="2">1</td></tr><tr><td>Average number of children couples have in their households</td><td colspan="2">4</td><td colspan="2">4</td></tr></table>
<table><tr><td>Characteristics</td><td colspan="2">Matrilineal</td><td colspan="2">Patrilineal</td></tr><tr><td>Couples with HIV+ children</td><td colspan="2">2</td><td colspan="2">0</td></tr></table>
3b146e448969395df83ed958dc73f78d39e943d22f71bf766aca94266e2f1180.png
simple
<table><tr><td>Category</td><td></td></tr><tr><td>Total number of reads</td><td>1,366,749</td></tr><tr><td>Total length of reads (bp)</td><td>625,825,203</td></tr><tr><td>Total number of reads cleaned</td><td>1,361,424</td></tr><tr><td>Total length of reads cleaned (bp)</td><td>598,655,879</td></tr><tr><td>Number of reads placed</td><td>1,302,023</td></tr><tr><td>Number of singletons</td><td>10,992</td></tr><tr><td>Total length of singletons (bp)</td><td>3,714,066</td></tr><tr><td>Average length of singletons (bp)</td><td>337</td></tr><tr><td>Largest singleton (bp)</td><td>692</td></tr><tr><td>Number of contigs</td><td>39,088</td></tr><tr><td>Total length of contigs (bp)</td><td>22,806,009</td></tr><tr><td>Average length of contigs (bp)</td><td>583</td></tr><tr><td>Largest contig (bp)</td><td>6,401</td></tr><tr><td>Average read coverage of contigs</td><td>24</td></tr></table>
<table><tr><td>Category</td><td></td></tr><tr><td>Total number of reads</td><td>1,366,749</td></tr><tr><td>Total length of reads (bp)</td><td>625,825,203</td></tr></table>
<table><tr><td>Total number of reads cleaned</td><td>1,361,424</td></tr><tr><td>Total length of reads cleaned (bp)</td><td>598,655,879</td></tr><tr><td>Number of reads placed</td><td>1,302,023</td></tr><tr><td>Number of singletons</td><td>10,992</td></tr><tr><td>Total length of singletons (bp)</td><td>3,714,066</td></tr><tr><td>Average length of singletons (bp)</td><td>337</td></tr><tr><td>Largest singleton (bp)</td><td>692</td></tr><tr><td>Number of contigs</td><td>39,088</td></tr><tr><td>Total length of contigs (bp)</td><td>22,806,009</td></tr><tr><td>Average length of contigs (bp)</td><td>583</td></tr><tr><td>Largest contig (bp)</td><td>6,401</td></tr><tr><td>Average read coverage of contigs</td><td>24</td></tr></table>
b896478b66008eabf87841b5d1dbea0a753a0c490afed1837f70318007d6c025.png
simple
<table><tr><td>control</td><td>condition</td><td>YKO<sub>aux</sub></td><td>BC<sub>prot</sub></td><td>PB<sub>prot</sub></td></tr><tr><td>SC</td><td>control</td><td>3</td><td>3</td><td>3</td></tr><tr><td>SC</td><td>ADE&#8211;</td><td>3</td><td>3</td><td>3</td></tr><tr><td>SC</td><td>ARG&#8211;</td><td>3</td><td>3</td><td>3</td></tr><tr><td>SC</td><td>HIS&#8211;</td><td>0</td><td>3</td><td>3</td></tr><tr><td>SC</td><td>LEU&#8211;</td><td>0</td><td>3</td><td>3</td></tr><tr><td>SC</td><td>LYS&#8211;</td><td>3</td><td>2</td><td>3</td></tr><tr><td>SC</td><td>MET&#8211;</td><td>3</td><td>3</td><td>3</td></tr><tr><td>SC</td><td>SER&#8211;</td><td>3</td><td>2</td><td>3</td></tr><tr><td>SC</td><td>THR&#8211;</td><td>3</td><td>2</td><td>3</td></tr><tr><td>SC</td><td>TRP&#8211;</td><td>3</td><td>3</td><td>3</td></tr><tr><td>SC</td><td>URA&#8211;</td><td>0</td><td>3</td><td>3</td></tr><tr><td>SC</td><td>MM*</td><td>3</td><td>4</td><td>5</td></tr><tr><td>SC</td><td>MM + URA</td><td>0</td><td>1</td><td>1</td></tr><tr><td>YPD</td><td>control</td><td>11</td><td>14</td><td>12</td></tr><tr><td>YPD</td><td>cisplatin, DNA cross-linking agent</td><td>3</td><td>4</td><td>3</td></tr><tr><td>YPD</td><td>CCCP, protonophore inhibitor of oxidative phosphorylation</td><td>3</td><td>3</td><td>3</td></tr><tr><td>YPD</td><td>FCCP, protonophore inhibitor of oxidative phosphorylation</td><td>3</td><td>3</td><td>3</td></tr><tr><td>YPD</td><td>PYRQ, novel quinolone compound, PCID 16001701</td><td>4</td><td>4</td><td>4</td></tr><tr><td>YPD</td><td>YPG, obligate respiratory</td><td>2</td><td>4</td><td>4</td></tr></table>
<table><tr><td>control</td><td>condition</td><td>YKOaux</td><td>BCprot</td><td>PBprot</td></tr><tr><td>SC</td><td>control</td><td>3</td><td>3</td><td>3</td></tr><tr><td>SC</td><td>ADE–</td><td>3</td><td>3</td><td>3</td></tr><tr><td>SC</td><td>ARG–</td><td>3</td><td>3</td><td>3</td></tr><tr><td>SC</td><td>HIS–</td><td>0</td><td>3</td><td>3</td></tr><tr><td>SC</td><td>LEU–</td><td>0</td><td>3</td><td>3</td></tr><tr><td>SC</td><td>LYS–</td><td>3</td><td>2</td><td>3</td></tr><tr><td>SC</td><td>MET–</td><td>3</td><td>3</td><td>3</td></tr><tr><td>SC</td><td>SER–</td><td>3</td><td>2</td><td>3</td></tr><tr><td>SC</td><td>T</td><td>3</td><td>2</td><td></td></tr></table>
<table><tr><td></td><td>HR–</td><td></td><td></td><td>3</td></tr><tr><td>SC</td><td>TRP–</td><td>3</td><td>3</td><td>3</td></tr><tr><td>SC</td><td>URA–</td><td>0</td><td>3</td><td>3</td></tr><tr><td>SC</td><td>MM*</td><td>3</td><td>4</td><td>5</td></tr><tr><td>SC</td><td>MM + URA</td><td>0</td><td>1</td><td>1</td></tr><tr><td>YPD</td><td>control</td><td>11</td><td>14</td><td>12</td></tr><tr><td>YPD</td><td>cisplatin, DNA cross-linking agent</td><td>3</td><td>4</td><td>3</td></tr><tr><td>YPD</td><td>CCCP, protonophore inhibitor of oxidative phosphorylation</td><td>3</td><td>3</td><td>3</td></tr><tr><td>YPD</td><td>FCCP, protonophore inhibitor of oxidative phosphorylation</td><td>3</td><td>3</td><td>3</td></tr><tr><td>YPD</td><td>PYRQ, novel quinolone compound, PCID 16001701</td><td>4</td><td>4</td><td>4</td></tr><tr><td>YPD</td><td>YPG, obligate respiratory</td><td>2</td><td>4</td><td>4</td></tr></table>
64534b602493a86c761d7459331d12cec7edd1563cee4921774cb5a84c11a36d.png
simple
<table><tr><td></td><td>Healthy non-smoker</td><td>Smokers without COPD</td><td>Smokers with COPD</td><td></td></tr><tr><td>IL-8 (pg/ml)</td><td>307 (225-558)</td><td>262 (208-407)</td><td>360 (165-474)</td><td>P = 0.512</td></tr><tr><td>MMP-9 (ng/ml)</td><td>338 (105-679)</td><td>170 (62-465)</td><td>217 (101-351)</td><td>P = 0.437</td></tr><tr><td>TIMP-1 (ng/ml)</td><td>449 (225-814)</td><td>354 (221-535)</td><td>360 (241-469)</td><td>P = 0.556</td></tr><tr><td>MMP-9/TIMP-1</td><td>0.54 (0.29-1.16)</td><td>0.37 (0.23-1.10)</td><td>0.38 (0.27-0.96)</td><td>P = 0.789</td></tr><tr><td>TNF-&#945; (pg/ml)</td><td>2.04 (1.19-3.82)</td><td>0.529*** (&lt;0.5-1.25)</td><td>0.704*** (&lt;0.5-1.23)</td><td>P &lt; 0.001</td></tr></table>
<table><tr><td></td><td>Healthy non-smoker</td><td>Smokers without COPD</td><td>Smokers with COPD</td><td></td></tr><tr><td>IL-8 (pg/ml)</td><td>307 (225-558)</td><td>262 (208-407)</td><td>360 (165-474)</td><td>P = 0.512</td></tr></table>
<table><tr><td></td><td>Healthy non-smoker</td><td>Smokers without COPD</td><td>Smokers with COPD</td><td></td></tr><tr><td>MMP-9 (ng/ml)</td><td>338 (105-679)</td><td>170 (62-465)</td><td>217 (101-351)</td><td>P = 0.437</td></tr><tr><td>TIMP-1 (ng/ml)</td><td>449 (225-814)</td><td>354 (221-535)</td><td>360 (241-469)</td><td>P = 0.556</td></tr><tr><td>MMP-9/TIMP-1</td><td>0.54 (0.29-1.16)</td><td>0.37 (0.23-1.10)</td><td>0.38 (0.27-0.96)</td><td>P = 0.789</td></tr><tr><td>TNF-α (pg/ml)</td><td>2.04 (1.19-3.82)</td><td>0.529*** (<0.5-1.25)</td><td>0.704*** (<0.5-1.23)</td><td>P < 0.001</td></tr></table>
0ed8e3f798a0429ecc33dcba0f23369f181f24be217b3cd9dd53c7d1d29169c1.png
complex
<table><tr><td></td><td colspan="3">Evaluation method: strict</td><td colspan="3">Evaluation method: average</td></tr><tr><td>Entity type</td><td>OG</td><td>OG+NN</td><td>OG+CRF</td><td>OG</td><td>OG+NN</td><td>OG+CRF</td></tr><tr><td>All</td><td>0.62</td><td>0.70</td><td>0.58</td><td>0.65</td><td>0.72</td><td>0.67</td></tr><tr><td>Chemicals</td><td>0.55</td><td>0.77</td><td>0.34</td><td>0.56</td><td>0.77</td><td>0.35</td></tr><tr><td>Cells</td><td>0.80</td><td>0.76</td><td>0.91</td><td>0.84</td><td>0.81</td><td>0.92</td></tr><tr><td>Biological processes/molecular functions</td><td>0.30</td><td>0.35</td><td>0.54</td><td>0.35</td><td>0.39</td><td>0.58</td></tr><tr><td>Cellular components</td><td>0.55</td><td>0.70</td><td>0.75</td><td>0.56</td><td>0.71</td><td>0.78</td></tr><tr><td>Organisms</td><td>0.44</td><td>0.94</td><td>0.87</td><td>0.45</td><td>0.94</td><td>0.88</td></tr><tr><td>Proteins</td><td>0.62</td><td>0.80</td><td>0.70</td><td>0.63</td><td>0.80</td><td>0.76</td></tr><tr><td>Sequences</td><td>0.54</td><td>0.75</td><td>0.12</td><td>0.57</td><td>0.76</td><td>0.13</td></tr></table>
<table><tr><td></td><td colspan="3">Evaluation method: strict</td><td colspan="2">Evaluation method: average</td></tr><tr><td>Entity type</td><td>OG</td><td>OG+NN</td><td>OG+CRF</td><td>OG</td><td>OG+NN</td></tr><tr><td>All</td><td>0.62</td><td>0.70</td><td>0.58</td><td>0.65</td><td>0.72</td></tr><tr><td>Chemicals</td><td>0.55</td><td>0.77</td><td>0.34</td><td>0.56</td><td>0.77</td></tr><tr><td>Cells</td><td>0.80</td><td>0.76</td><td>0.91</td><td>0.84</td><td>0.81</td></tr><tr><td>Biological processes/molecular functions</td><td>0.30</td><td>0.35</td><td>0.54</td><td>0.35</td><td>0.39</td></tr><tr><td>Cellular components</td><td>0.55</td><td>0.70</td><td>0.75</td><td>0.56</td><td>0.71</td></tr><tr><td>Organisms</td><td>0.44</td><td>0.94</td><td>0.87</td><td>0.45</td><td>0.94</td></tr><tr><td>Proteins</td><td>0.62</td><td>0.80</td><td>0.70</td><td>0.63</td><td>0.80</td></tr><tr><td>Sequences</td><td>0.54</td><td>0.75</td><td>0.12</td><td>0.57</td><td>0.76</td></tr></table>
<table><tr><td>Evaluation method: average</td></tr><tr><td>OG+CRF</td></tr><tr><td>0.67</td></tr><tr><td>0.35</td></tr><tr><td>0.92</td></tr><tr><td>0.58</td></tr><tr><td>0.78</td></tr><tr><td>0.88</td></tr><tr><td>0.76</td></tr><tr><td>0.13</td></tr></table>
43b68d39274509ab3e3b2408ea8030297f53aca95d0879612e4555d7637aba30.png
complex
<table><tr><td>uORF homology group</td><td>uORF length (amino acids)</td><td colspan="5">Conserved sequence features</td></tr><tr><td></td><td></td><td>Length conserved at N- and C-Termini</td><td>N-terminus (amino acids)</td><td>Middle (amino acids)</td><td>C-terminus (amino acids)</td><td>Overall</td></tr><tr><td colspan="7">uORF features conserved between Arabidopsis and rice</td></tr><tr><td>1</td><td>25&#8211;43</td><td>C-terminus</td><td></td><td></td><td>SY-rich: 5/14</td><td>20&#8211;39% STY</td></tr><tr><td>2</td><td>34&#8211;39</td><td>C-terminus</td><td></td><td></td><td>KR-rich: 5&#8211;6/20</td><td>18&#8211;24% KR</td></tr><tr><td>3</td><td>50&#8211;54</td><td>N- and C-termini</td><td>K-rich: 4/9</td><td>S-rich: 5&#8211;6/6</td><td>KR-rich: 4&#8211;5/16, SY-rich: 4&#8211;5/12</td><td>17&#8211;23% KR. 22&#8211;29% SY</td></tr><tr><td>4</td><td>52&#8211;55</td><td>N- and C-termini</td><td></td><td></td><td>SY-rich: 7/30</td><td>21&#8211;23% STY</td></tr><tr><td>5</td><td>38&#8211;41</td><td>N- and C-termini</td><td></td><td></td><td></td><td></td></tr><tr><td>6</td><td>55&#8211;68</td><td>N-terminus</td><td></td><td></td><td></td><td></td></tr><tr><td>7</td><td>57&#8211;105</td><td>N-terminus</td><td>STY-rich: 6&#8211;7/22</td><td>KR-rich: 4/5&#8211;8</td><td></td><td></td></tr><tr><td>8</td><td>61&#8211;62</td><td>N- and C-termini</td><td></td><td></td><td></td><td>CHCH domain, 17% KR</td></tr><tr><td>9</td><td>17&#8211;33</td><td>N-terminus</td><td></td><td></td><td></td><td></td></tr><tr><td>10.1</td><td>41</td><td>N- and C-termini</td><td></td><td></td><td></td><td></td></tr><tr><td>11</td><td>24&#8211;44</td><td>C-terminus</td><td></td><td></td><td>KR-rich: 5&#8211;6/15</td><td>25% KR</td></tr><tr><td>12</td><td>39&#8211;51</td><td>N- and C-termini</td><td></td><td></td><td></td><td></td></tr><tr><td>13</td><td>25</td><td>N- and C-termini</td><td></td><td>RS-rich: 10&#8211;12/18</td><td></td><td>40&#8211;48% RS</td></tr><tr><td>14</td><td>29</td><td>N-terminus</td><td></td><td>ST-rich: 4&#8211;6/10</td><td></td><td>14&#8211;32% STY</td></tr><tr><td>15.1</td><td>18&#8211;27</td><td>N- and C-termini</td><td></td><td></td><td>8/9 hydrophobic</td><td></td></tr><tr><td>15.3</td><td>43&#8211;54</td><td>N- and C-termini</td><td></td><td></td><td>13/14 completely conserved</td><td></td></tr><tr><td>16</td><td>40&#8211;62</td><td>C-terminus</td><td></td><td></td><td></td><td></td></tr><tr><td>17</td><td>36&#8211;45</td><td>C-terminus</td><td></td><td></td><td></td><td></td></tr><tr><td>18</td><td>36&#8211;38</td><td>Neither</td><td></td><td></td><td></td><td></td></tr><tr><td>19</td><td>30&#8211;34</td><td>N-terminus</td><td></td><td></td><td></td><td>29% ST</td></tr><tr><td colspan="7">uORF features conserved between Arabidopsis paralogs</td></tr><tr><td>20</td><td>41&#8211;43</td><td>N- and C-termini</td><td>STY-rich: 8&#8211;9/27</td><td></td><td></td><td>23% STY</td></tr><tr><td>21</td><td>87&#8211;90</td><td>N- and C-termini</td><td></td><td>ST-rich: 11&#8211;12/17&#8211;22</td><td></td><td>22&#8211;25% ST</td></tr><tr><td>22</td><td>25</td><td>N- and C-termini</td><td></td><td></td><td></td><td></td></tr><tr><td>23</td><td>69&#8211;71</td><td>Neither</td><td></td><td></td><td></td><td></td></tr><tr><td>24</td><td>31&#8211;34</td><td>N- and C-termini</td><td></td><td></td><td></td><td></td></tr><tr><td>25</td><td>25</td><td>N- and C-termini</td><td></td><td></td><td></td><td></td></tr><tr><td>26</td><td>22</td><td>N-terminus</td><td></td><td></td><td></td><td></td></tr></table>
<table><tr><td>uORF homology group</td><td>uORF length (amino acids)</td><td colspan="5">Conserved sequence features</td></tr><tr><td></td><td></td><td>Length conserved at N- and C-Termini</td><td>N-terminus (amino acids)</td><td>Middle (amino acids)</td><td>C-terminus (amino acids)</td><td>Overall</td></tr><tr><td colspan="7">uORF features conserved between Arabidopsis and rice</td></tr><tr><td>1</td><td>25–43</td><td>C-terminus</td><td></td><td></td><td>SY-rich: 5/14</td><td>20–39% STY</td></tr><tr><td>2</td><td>34–39</td><td>C-terminus</td><td></td><td></td><td>KR-rich: 5–6/20</td><td>18–24% KR</td></tr><tr><td>3</td><td>50–54</td><td>N- and C-termini</td><td>K-rich: 4/9</td><td>S-rich: 5–6/6</td><td>KR-rich: 4–5/16, SY-rich: 4–5/12</td><td>17–23% KR. 22–29% SY</td></tr><tr><td>4</td><td>52–55</td><td>N- and C-termini</td><td></td><td></td><td>SY-rich: 7/30</td><td>21–23% STY</td></tr><tr><td>5</td><td>38–41</td><td>N- and C-termini</td><td></td><td></td><td></td><td></td></tr><tr><td>6</td><td>55–68</td><td>N-terminus</td><td></td><td></td><td></td><td></td></tr><tr><td>7</td><td>57–105</td><td>N-terminus</td><td>STY-rich: 6–7/22</td><td>KR-rich: 4/5–8</td><td></td><td></td></tr><tr><td>8</td><td>61–62</td><td>N- and C-termini</td><td></td><td></td><td></td><td>CHCH domain, 17% KR</td></tr><tr><td>9</td><td>17–33</td><td>N-terminus</td><td></td><td></td><td></td><td></td></tr><tr><td>10.1</td><td>41</td><td>N- and C-termini</td><td></td><td></td><td></td><td></td></tr><tr><td>11</td><td>24–44</td><td>C-terminus</td><td></td><td></td><td>KR-rich: 5–6/15</td><td>25% KR</td></tr><tr><td>12</td><td>39–51</td><td>N- and C-termini</td><td></td><td></td><td></td><td></td></tr><tr><td>13</td><td>25</td><td>N- and C-termini</td><td></td><td>RS-rich: 10–12/18</td><td></td><td>40–48% RS</td></tr><tr><td>14</td><td>29</td><td>N-terminus</td><td></td><td>ST-rich: 4–6/10</td><td></td><td>14–32% STY</td></tr><tr><td>15.1</td><td>18–27</td><td>N- and C-termini</td><td></td><td></td><td>8/9 hydrophobic</td><td></td></tr><tr><td>15.3</td><td>43–54</td><td>N- and C-termini</td><td></td><td></td><td>13/14 completely conserved</td><td></td></tr><tr><td>16</td><td>40–62</td><td>C-terminus</td><td></td><td></td><td></td><td></td></tr><tr><td>17</td><td>36–45</td><td>C-terminus</td><td></td><td></td><td></td><td></td></tr><tr><td>18</td><td>36–38</td><td>Neither</td><td></td><td></td><td></td><td></td></tr><tr><td>19</td><td>30–34</td><td>N-terminus</td><td></td><td></td><td></td><td>29% ST</td></tr><tr><td colspan="7">uORF features conserved between Arabidopsis paralogs</td></tr><tr><td>20</td><td>41–43</td><td>N- and C-termini</td><td>STY-rich: 8–9/27</td><td></td><td></td><td>23% STY</td></tr></table>
<table><tr><td>21</td><td>87–90</td><td>N- and C-termini</td><td></td><td>ST-rich: 11–12/17–22</td><td></td><td>22–25% ST</td></tr><tr><td>22</td><td>25</td><td>N- and C-termini</td><td></td><td></td><td></td><td></td></tr><tr><td>23</td><td>69–71</td><td>Neither</td><td></td><td></td><td></td><td></td></tr><tr><td>24</td><td>31–34</td><td>N- and C-termini</td><td></td><td></td><td></td><td></td></tr><tr><td>25</td><td>25</td><td>N- and C-termini</td><td></td><td></td><td></td><td></td></tr><tr><td>26</td><td>22</td><td>N-terminus</td><td></td><td></td><td></td><td></td></tr></table>
f437eb68db2897acd74ac124986fb187e0c446c64d1a9db561984c3ea8607787.png
simple
<table><tr><td>Assay</td><td>Cyclohexane extract</td><td>Ethanolic extract</td><td>Water extract</td></tr><tr><td>ORAC-PYR (mTE/g)</td><td>1.5 &#177; 0.4</td><td>28.1 &#177; 2.5</td><td>13.7 &#177; 1.3</td></tr><tr><td>DPPH (mTE/g)</td><td>0.20 &#177; 0.03</td><td>2.25 &#177; 0.07</td><td>1.01 &#177; 0.07</td></tr><tr><td>DPPH (IC<sub>50</sub> &#956;g/mL)</td><td>95.0 &#177; 0.2</td><td>24.2 &#177; 0.5</td><td>24.5 &#177; 0.8</td></tr><tr><td>TEAC (mTE/g)</td><td>0.64 &#177; 0.09</td><td>7.22 &#177; 0.08</td><td>5.32 &#177; 0.02</td></tr><tr><td>TEAC (IC<sub>50</sub> mg/mL)</td><td>0.800 &#177; 0.132</td><td>0.071 &#177; 0.009</td><td>0.089 &#177; 0.002</td></tr><tr><td>FRAP (mTE/g)</td><td>0.27 &#177; 0.01</td><td>6.70 &#177; 0.03</td><td>6.69 &#177; 0.09</td></tr><tr><td>FRAP (mmol Fe<sup>II</sup>/g)</td><td>1.20 &#177; 0.01</td><td>22.5 &#177; 0.1</td><td>20.9 &#177; 0.1</td></tr><tr><td>Total phenolics (mGAE/g)</td><td>1.22 &#177; 0.12</td><td>7.82 &#177; 0.01</td><td>4.32 &#177; 0.05</td></tr><tr><td>Total flavonoids (mCE/g)</td><td>0.18 &#177; 0.01</td><td>0.63 &#177; 0.01</td><td>0.69 &#177; 0.02</td></tr><tr><td>Total anthocyanin (mg cyanidin 3-<i>O</i>-glucoside/g)</td><td>n.d.</td><td>n.d.</td><td>n.d.</td></tr></table>
<table><tr><td>Assay</td><td>Cyclohexane extract</td><td>Ethanolic extract</td></tr><tr><td>ORAC-PYR (mTE/g)</td><td>1.5 ± 0.4</td><td>28.1 ± 2.5</td></tr><tr><td>DPPH (mTE/g)</td><td>0.20 ± 0.03</td><td>2.25 ± 0.07</td></tr><tr><td>DPPH (IC50 μg/mL)</td><td>95.0 ± 0.2</td><td>24.2 ± 0.5</td></tr><tr><td>TEAC (mTE/g)</td><td>0.64 ± 0.09</td><td>7.22 ± 0.08</td></tr><tr><td>TEAC (IC50 mg/mL)</td><td>0.800 ± 0.132</td><td>0.071 ± 0.009</td></tr><tr><td>FRAP (mTE/g)</td><td>0.27 ± 0.01</td><td>6.70 ± 0.03</td></tr><tr><td>FRAP (mmol FeII/g)</td><td>1.20 ± 0.01</td><td>22.5 ± 0.1</td></tr><tr><td>Total phenolics (mGAE/g)</td><td>1.22 ± 0.12</td><td>7.82 ± 0.01</td></tr><tr><td>Total flavonoids (mCE/g)</td><td>0.18 ± 0.01</td><td>0.63 ± 0.01</td></tr><tr><td>Total anthocyanin (mg cyanidin 3-O-glucoside/g)</td><td>n.d.</td><td>n.d.</td></tr></table>
<table><tr><td>Water extract</td></tr><tr><td>13.7 ± 1.3</td></tr><tr><td>1.01 ± 0.07</td></tr><tr><td>24.5 ± 0.8</td></tr><tr><td>5.32 ± 0.02</td></tr><tr><td>0.089 ± 0.002</td></tr><tr><td>6.69 ± 0.09</td></tr><tr><td>20.9 ± 0.1</td></tr><tr><td>4.32 ± 0.05</td></tr><tr><td>0.69 ± 0.02</td></tr><tr><td>n.d.</td></tr></table>
1640a49de9d2d9952992914412f49cd8d6fec928b229e642f7aaa2e338f647f3.png
simple
<table><tr><td>Population</td><td>mu (empirical)</td><td>C.I. for mu (empirical)</td><td>C.I. for simulations</td><td>C.I. bootstrapped data</td></tr><tr><td>BKL</td><td>5.6178e-05</td><td>&#8722;1.1812e-04 to 2.3048e-04</td><td>&#8722;1.2157e-07 to 1.1975e-07</td><td>&#8722;1.0721e-05 to 1.2234e-04</td></tr><tr><td>MHX</td><td>4.1704e-04</td><td>1.5234e-05 to 8.1885e-04</td><td>&#8722;3.9497e-06 to 3.9043e-06</td><td>1.3536e-04 to 5.3538e-04</td></tr></table>
<table><tr><td>Population</td><td>mu (empirical)</td><td>C.I. for mu (empirical)</td><td>C.I. for simulations</td><td>C.I. bootstrapped data</td></tr><tr><td>BKL</td><td>5.6178e-05</td><td>−1.1812e-04 to 2.3048e-04</td><td>−1.2157e-07 to 1.1975e-07</td><td>−1.0721e-05 to 1.2234e-04</td></tr></table>
<table><tr><td>MHX</td><td>4.1704e-04</td><td>1.5234e-05 to 8.1885e-04</td><td>−3.9497e-06 to 3.9043e-06</td><td>1.3536e-04 to 5.3538e-04</td></tr></table>
192768529d7d610b1ee7acb08e56825539e9d3fc34df55571e5b4a9bfb406704.png
complex
<table><tr><td></td><td>Baseline</td><td>6-month</td><td></td></tr><tr><td></td><td>Mean (SD)</td><td>Mean (SD)</td><td><i>P</i> value</td></tr><tr><td colspan="4">Knowledge</td></tr><tr><td> General knowledge on health and tobacco use (range: 0&#8211;7)</td><td>4.5 &#177; 1.0</td><td>5.2 &#177; 0.7</td><td>0.02</td></tr><tr><td> Specific knowledge on smoking-related diseases (range: 0&#8211;10)</td><td>7.6 &#177; 2</td><td>7.7 &#177; 1.6</td><td>0.8</td></tr><tr><td colspan="4">Attitudes <sup>a</sup></td></tr><tr><td> Banning all tobacco advertisement</td><td>3.4 &#177; 0.5</td><td>3.3 &#177; 0.6</td><td>0.14</td></tr><tr><td> Recognition of own &amp; professional role in smoking cessation counseling</td><td>3.3 &#177; 0.4</td><td>3.2 &#177; 0.3</td><td>0.17</td></tr><tr><td> Bad image of woman smokers</td><td>2.97 &#177; 0.3</td><td>3.2 &#177; 0.3</td><td>0.001</td></tr><tr><td>Practice in smoking cessation counseling</td><td>n (%)</td><td>n (%)</td><td></td></tr><tr><td> Had practiced</td><td>15 (62.5)</td><td>12 (55.0)</td><td>-</td></tr><tr><td> Among those who had practiced <sup>b</sup></td><td></td><td></td><td></td></tr><tr><td> Ask</td><td>0.83 (1.0)</td><td>0.92 (0.9)</td><td></td></tr><tr><td> Advise</td><td>1.38 (1.1)</td><td>1.38 (0.8)</td><td></td></tr><tr><td> Assess</td><td>0.92 (1.0)</td><td>0.92 (0.9)</td><td></td></tr><tr><td> Assist</td><td>1.00 (1.1)</td><td>1.15 (0.9)</td><td></td></tr><tr><td> Arrange</td><td>0.42 (0.9)</td><td>0.17 (0.4)</td><td></td></tr></table>
<table><tr><td></td><td>Baseline</td><td>6-month</td><td></td></tr><tr><td></td><td>Mean (SD)</td><td>Mean (SD)</td><td>P value</td></tr><tr><td colspan="4">Knowledge</td></tr><tr><td>General knowledge on health and tobacco use (range: 0–7)</td><td>4.5 ± 1.0</td><td>5.2 ± 0.7</td><td>0.02</td></tr><tr><td>Specific knowledge on smoking-related diseases (range: 0–10)</td><td>7.6 ± 2</td><td>7.7 ± 1.6</td><td>0.8</td></tr><tr><td colspan="4">Attitudes a</td></tr><tr><td>Banning all tobacco advertisement</td><td>3.4 ± 0.5</td><td>3.3 ± 0.6</td><td>0.14</td></tr><tr><td>Recognition of own & professional role in smoking cessation counseling</td><td>3.3 ± 0.4</td><td>3.2 ± 0.3</td><td>0.17</td></tr><tr><td>Bad image of woman smokers</td><td>2.97 ± 0.3</td><td>3.2 ± 0.3</td><td>0.001</td></tr><tr><td>Practice in smoking cessation counseling</td><td>n (%)</td><td>n (%)</td><td></td></tr><tr><td>Had practiced</td><td>15 (62.5)</td><td>12 (55.0)</td><td>-</td></tr><tr><td>Among those who had practiced b</td><td></td><td></td><td></td></tr></table>
<table><tr><td>Ask</td><td>0.83 (1.0)</td><td>0.92 (0.9)</td></tr><tr><td>Advise</td><td>1.38 (1.1)</td><td>1.38 (0.8)</td></tr><tr><td>Assess</td><td>0.92 (1.0)</td><td>0.92 (0.9)</td></tr><tr><td>Assist</td><td>1.00 (1.1)</td><td>1.15 (0.9)</td></tr><tr><td>Arrange</td><td>0.42 (0.9)</td><td>0.17 (0.4)</td></tr></table>
fe3e3acc8c5c43159caaf6d2568849e7ee423d2d7c84408802674ff0ef759134.png
simple
<table><tr><td> Parameter</td><td> Step size <i>&#945;</i></td><td> Nr. epochs</td><td> Decay constant <i>&#955;</i></td></tr><tr><td></td><td> 0.3</td><td> 10</td><td><i>N</i>/4</td></tr></table>
<table><tr><td>Parameter</td><td>Step size α</td><td>Nr. epochs</td><td>Decay constant λ</td></tr></table>
<table><tr><td></td><td>0.3</td><td>10</td><td>N/4</td></tr></table>
2b5d101760949a68abc390c8169708d2e1ce4399cd58e40ad12b99a5d3901a9a.png
complex
<table><tr><td>Research procedure</td><td colspan="2">Responder</td><td>Definitely Yes (%)</td><td>Probably Yes (%)</td><td>Probably No (%)</td><td>Definitely No (%)</td></tr><tr><td rowspan="5">&#8220;Drawing 1 extra vial of blood for research purposes when other blood is being obtained for clinical purposes. (Would not require an extra blood draw.)&#8221;</td><td rowspan="4">Parent by Infant Status</td><td>NICU &#8804; 31 wks</td><td>50</td><td>22</td><td>15</td><td>13</td></tr><tr><td>NICU 34-36 wks</td><td>45</td><td>38</td><td>3</td><td>13</td></tr><tr><td>NICU Term with hypoglycemia</td><td>45</td><td>45</td><td>8</td><td>3</td></tr><tr><td>Well-Baby Nursery/Mother-Baby Unit (37-42 weeks)</td><td>45</td><td>43</td><td>10</td><td>3</td></tr><tr><td colspan="2">Healthcare Provider</td><td>66</td><td>32</td><td>2</td><td>0</td></tr><tr><td rowspan="5">&#8220;Drawing 1 extra vial of blood for research purposes only. (Would require an extra blood draw.)&#8221;</td><td rowspan="4">Parent by Infant Status</td><td>NICU &#8804; 31 wks</td><td>12</td><td>32</td><td>37</td><td>20</td></tr><tr><td>NICU 34-36 wks</td><td>28</td><td>42</td><td>15</td><td>15</td></tr><tr><td>NICU Term with hypoglycemia</td><td>18</td><td>33</td><td>33</td><td>15</td></tr><tr><td>Well-Baby Nursery/Mother-Baby Unit (37-42 weeks)</td><td>32</td><td>33</td><td>33</td><td>15</td></tr><tr><td colspan="2">Healthcare Provider</td><td>22</td><td>41</td><td>28</td><td>10</td></tr><tr><td rowspan="5">&#8220;2 Echocardiograms (heart ultrasound). These are not associated with any pain, but occasionally some infants can feel slight discomfort&#8221;</td><td rowspan="4">Parent by Infant Status</td><td>NICU &#8804; 31 wks</td><td>33</td><td>55</td><td>12</td><td>5</td></tr><tr><td>NICU 34-36 wks</td><td>22</td><td>52</td><td>12</td><td>14</td></tr><tr><td>NICU Term with hypoglycemia</td><td>18</td><td>56</td><td>25</td><td>0</td></tr><tr><td>Well-Baby Nursery/Mother-Baby Unit (37-42 weeks)</td><td>30</td><td>43</td><td>23</td><td>3</td></tr><tr><td colspan="2">Healthcare Provider</td><td>50</td><td>48</td><td>2</td><td>0</td></tr><tr><td rowspan="5">&#8220;MRI brain without sedation&#8221;</td><td rowspan="4">Parent by Infant Status</td><td>NICU &#8804; 31 wks</td><td>20</td><td>40</td><td>20</td><td>20</td></tr><tr><td>NICU 34-36 wks</td><td>20</td><td>25</td><td>27</td><td>28</td></tr><tr><td>NICU Term with hypoglycemia</td><td>7</td><td>27</td><td>40</td><td>20</td></tr><tr><td>Well-Baby Nursery/Mother-Baby Unit (37-42 weeks)</td><td>12</td><td>22</td><td>42</td><td>23</td></tr><tr><td colspan="2">Healthcare Provider</td><td>28</td><td>38</td><td>24</td><td>11</td></tr><tr><td rowspan="5">&#8220;MRI brain with sedation&#8221;</td><td rowspan="4">Parent by Infant Status</td><td>NICU &#8804; 31 wks</td><td>15</td><td>38</td><td>27</td><td>30</td></tr><tr><td>NICU 34-36 wks</td><td>12</td><td>18</td><td>37</td><td>33</td></tr><tr><td>NICU Term with hypoglycemia</td><td>5</td><td>21</td><td>20</td><td>54</td></tr><tr><td>Well-Baby Nursery/Mother-Baby Unit (37-42 weeks)</td><td>5</td><td>20</td><td>39</td><td>36</td></tr><tr><td colspan="2">Healthcare Provider</td><td>3</td><td>16</td><td>48</td><td>33</td></tr></table>
<table><tr><td>Research procedure</td><td>Responder</td></tr><tr><td rowspan="5">“Drawing 1 extra vial of blood for research purposes when other blood is being obtained for clinical purposes. (Would not require an extra blood draw.)”</td><td rowspan="4">Parent by Infant Status</td></tr><tr></tr><tr></tr><tr></tr><tr><td>Healthcare Provider</td></tr><tr><td rowspan="5">“Drawing 1 extra vial of blood for research purposes only. (Would require an extra blood draw.)”</td><td rowspan="4">Parent by Infant Status</td></tr><tr></tr><tr></tr><tr></tr><tr><td>Healthcare Provider</td></tr><tr><td rowspan="5">“2 Echocardiograms (heart ultrasound). These are not associated with any pain, but occasionally some infants can feel slight discomfort”</td><td rowspan="4">Parent by Infant Status</td></tr><tr></tr><tr></tr><tr></tr><tr><td>Healthcare Provider</td></tr><tr><td rowspan="5">“MRI brain without sedation”</td><td rowspan="4">Parent by Infant Status</td></tr><tr></tr><tr></tr><tr></tr><tr><td>Healthcare Provider</td></tr><tr><td rowspan="5">“MRI brain with sedation”</td><td rowspan="4">Parent by Infant Status</td></tr><tr></tr><tr></tr><tr></tr><tr><td>Healthcare Provider</td></tr></table>
<table><tr><td>Responder</td><td>Definitely Yes (%)</td><td>Probably Yes (%)</td><td>Probably No (%)</td><td>Definitely No (%)</td></tr><tr><td>NICU ≤ 31 wks</td><td>50</td><td>22</td><td>15</td><td>13</td></tr><tr><td>NICU 34-36 wks</td><td>45</td><td>38</td><td>3</td><td>13</td></tr><tr><td>NICU Term with hypoglycemia</td><td>45</td><td>45</td><td>8</td><td>3</td></tr><tr><td>Well-Baby Nursery/Mother-Baby Unit (37-42 weeks)</td><td>45</td><td>43</td><td>10</td><td>3</td></tr><tr><td>Healthcare Provider</td><td>66</td><td>32</td><td>2</td><td>0</td></tr><tr><td>NICU ≤ 31 wks</td><td>12</td><td>32</td><td>37</td><td>20</td></tr><tr><td>NICU 34-36 wks</td><td>28</td><td>42</td><td>15</td><td>15</td></tr><tr><td>NICU Term with hypoglycemia</td><td>18</td><td>33</td><td>33</td><td>15</td></tr><tr><td>Well-Baby Nursery/Mother-Baby Unit (37-42 weeks)</td><td>32</td><td>33</td><td>33</td><td>15</td></tr><tr><td>Healthcare Provider</td><td>22</td><td>41</td><td>28</td><td>10</td></tr><tr><td>NICU ≤ 31 wks</td><td>33</td><td>55</td><td>12</td><td>5</td></tr><tr><td>NICU 34-36 wks</td><td>22</td><td>52</td><td>12</td><td>14</td></tr><tr><td>NICU Term with hypoglycemia</td><td>18</td><td>56</td><td>25</td><td>0</td></tr><tr><td>Well-Baby Nursery/Mother-Baby Unit (37-42 weeks)</td><td>30</td><td>43</td><td>23</td><td>3</td></tr><tr><td>Healthcare Provider</td><td>50</td><td>48</td><td>2</td><td>0</td></tr><tr><td>NICU ≤ 31 wks</td><td>20</td><td>40</td><td>20</td><td>20</td></tr><tr><td>NICU 34-36 wks</td><td>20</td><td>25</td><td>27</td><td>28</td></tr><tr><td>NICU Term with hypoglycemia</td><td>7</td><td>27</td><td>40</td><td>20</td></tr><tr><td>Well-Baby Nursery/Mother-Baby Unit (37-42 weeks)</td><td>12</td><td>22</td><td>42</td><td>23</td></tr><tr><td>Healthcare Provider</td><td>28</td><td>38</td><td>24</td><td>11</td></tr><tr><td>NICU ≤ 31 wks</td><td>15</td><td>38</td><td>27</td><td>30</td></tr><tr><td>NICU 34-36 wks</td><td>12</td><td>18</td><td>37</td><td>33</td></tr><tr><td>NICU Term with hypoglycemia</td><td>5</td><td>21</td><td>20</td><td>54</td></tr><tr><td>Well-Baby Nursery/Mother-Baby Unit (37-42 weeks)</td><td>5</td><td>20</td><td>39</td><td>36</td></tr><tr><td>Healthcare Provider</td><td>3</td><td>16</td><td>48</td><td>33</td></tr></table>
9e1f4f5d361c777a43149c64dbe4b69f1259847bba6a1e4550f68a6433a19e88.png
simple
<table><tr><td>Ethical view</td><td>Emic view (relative frequency) n = 65</td><td>Possibilities</td></tr><tr><td><i>Finning</i>[100]</td><td>&#8220;Fishing that only takes shark fins (63,4%)</td><td>&#8220;Best monitor&#8221;; &#8220;Give high fine&#8221;</td></tr><tr><td>Immature Capture [101]</td><td>Fish small sharks (61,9%)</td><td>&#8220;drop the baby sharks&#8221;, put closure, &#8220;increase the mesh of the nets&#8221;</td></tr><tr><td><i>Bycatch</i> Capture [102]</td><td>&#8220;Fishing with trawlnet&#8221;, &#8220;fishnet excess&#8221;, &#8220;stuck with longline hook in steel&#8221; (46,8%)</td><td>&#8220;forbid trawling&#8221;, &#8220;control gillnets use&#8221;, &#8220;forbid longline hooks stuck with Spiral wire Rope use&#8221;</td></tr><tr><td>Females Capture [70]</td><td>&#8220;female fishing&#8221;; &#8220;fish a female carrying a baby shark in the belly&#8221; (15,1%)</td><td>&#8220;Drop females&#8221;; &#8220;make closure&#8221;</td></tr></table>
<table><tr><td>Ethical view</td><td>Emic view (relative frequency) n = 65</td><td>Possibilities</td></tr><tr><td>Finn</td><td>“Fishing that </td><td>“Best monitor”; “Give high f</td></tr></table>
<table><tr><td>ing[100]</td><td>only takes shark fins (63,4%)</td><td>ine”</td></tr><tr><td>Immature Capture [101]</td><td>Fish small sharks (61,9%)</td><td>“drop the baby sharks”, put closure, “increase the mesh of the nets”</td></tr><tr><td>Bycatch Capture [102]</td><td>“Fishing with trawlnet”, “fishnet excess”, “stuck with longline hook in steel” (46,8%)</td><td>“forbid trawling”, “control gillnets use”, “forbid longline hooks stuck with Spiral wire Rope use”</td></tr><tr><td>Females Capture [70]</td><td>“female fishing”; “fish a female carrying a baby shark in the belly” (15,1%)</td><td>“Drop females”; “make closure”</td></tr></table>
70a991ddb58389002b14624d37c5d85d97cedc26702404a1113304b809c467bc.png
complex
<table><tr><td rowspan="2">Measures</td><td colspan="4">MBCT, <i>n</i> (%)</td><td colspan="4">Self-help, <i>n</i> (%)</td></tr><tr><td>Recovered</td><td>Improved</td><td>Same</td><td>Deteriorated</td><td>Recovered</td><td>Improved</td><td>Same</td><td>Deteriorated</td></tr><tr><td colspan="9">Post-treatment</td></tr><tr><td colspan="9"> (MBCT = 28; Self-help = 32)</td></tr><tr><td>Concern over mistakes*</td><td>6 (21)</td><td>12 (43)</td><td>10 (36)</td><td>0 (0)</td><td>4 (13)</td><td>8 (25)</td><td>20 (63)</td><td>0 (0)</td></tr><tr><td>Clinical perfectionism</td><td>8 (29)</td><td>0 (0)</td><td>20 (71)</td><td>0 (0)</td><td>4 (13)</td><td>0 (0)</td><td>28 (88)</td><td>0 (0)</td></tr><tr><td>DASS depression*</td><td>10 (36)</td><td>4 (14)</td><td>11 (39)</td><td>3 (11)</td><td>3 (9)</td><td>5 (16)</td><td>22 (69)</td><td>2 (6)</td></tr><tr><td>DASS anxiety</td><td>3 (11)</td><td>3 (11)</td><td>22 (79)</td><td>0 (0)</td><td>3 (9)</td><td>2 (6)</td><td>26 (81)</td><td>1 (3)</td></tr><tr><td>DASS stress*</td><td>5 (18)</td><td>10 (36)</td><td>10 (36)</td><td>3 (11)</td><td>3 (9)</td><td>3 (9)</td><td>24 (75)</td><td>2 (6)</td></tr><tr><td colspan="9"> 10-week follow-up</td></tr><tr><td>Concern over mistakes</td><td>5 (18)</td><td>11 (39)</td><td>12 (43)</td><td>0 (0)</td><td>1 (3)</td><td>0 (0)</td><td>18 (56)</td><td>4 (13)</td></tr><tr><td>Clinical perfectionism*</td><td>10 (36)</td><td>0 (0)</td><td>18 (64)</td><td>0 (0)</td><td>4 (13)</td><td>0 (0)</td><td>27 (84)</td><td>1 (3)</td></tr><tr><td>DASS depression</td><td>7 (25)</td><td>5 (18)</td><td>12 (43)</td><td>4 (14)</td><td>6 (19)</td><td>3 (9)</td><td>18 (56)</td><td>5 (16)</td></tr><tr><td>DASS anxiety</td><td>3 (11)</td><td>5 (18)</td><td>18 (64)</td><td>2 (7)</td><td>3 (9)</td><td>4 (13)</td><td>22 (69)</td><td>3 (9)</td></tr><tr><td>DASS stress*</td><td>3 (11)</td><td>9 (32)</td><td>14 (50)</td><td>2 (7)</td><td>0 (0)</td><td>6 (19)</td><td>22 (69)</td><td>4 (13)</td></tr></table>
<table><tr><td rowspan="2">Measures</td><td colspan="4">MBCT, n (%)</td><td colspan="4">Self-help, n (%)</td></tr><tr><td>Recovered</td><td>Improved</td><td>Same</td><td>Deteriorated</td><td>Recovered</td><td>Improved</td><td>Same</td><td>Deteriorated</td></tr><tr><td colspan="9">Post-treatment</td></tr><tr><td colspan="9">(MBCT = 28; Self-help = 32)</td></tr><tr><td>Concern over mistakes*</td><td>6 (21)</td><td>12 (43)</td><td>10 (36)</td><td>0 (0)</td><td>4 (13)</td><td>8 (25)</td><td>20 (63)</td><td>0 (0)</td></tr><tr><td>Clinical perfectionism</td><td>8 (29)</td><td>0 (0)</td><td>20 (71)</td><td>0 (0)</td><td>4 (13)</td><td>0 (0)</td><td>28 (88)</td><td>0 (0)</td></tr></table>
<table><tr><td rowspan="2">Measures</td><td colspan="4">MBCT, n (%)</td><td colspan="4">Self-help, n (%)</td></tr><tr><td>Recovered</td><td>Improved</td><td>Same</td><td>Deteriorated</td><td>Recovered</td><td>Improved</td><td>Same</td><td>Deteriorated</td></tr><tr><td>DASS depression*</td><td>10 (36)</td><td>4 (14)</td><td>11 (39)</td><td>3 (11)</td><td>3 (9)</td><td>5 (16)</td><td>22 (69)</td><td>2 (6)</td></tr><tr><td>DASS anxiety</td><td>3 (11)</td><td>3 (11)</td><td>22 (79)</td><td>0 (0)</td><td>3 (9)</td><td>2 (6)</td><td>26 (81)</td><td>1 (3)</td></tr><tr><td>DASS stress*</td><td>5 (18)</td><td>10 (36)</td><td>10 (36)</td><td>3 (11)</td><td>3 (9)</td><td>3 (9)</td><td>24 (75)</td><td>2 (6)</td></tr><tr><td colspan="9">10-week follow-up</td></tr><tr><td>Concern over mistakes</td><td>5 (18)</td><td>11 (39)</td><td>12 (43)</td><td>0 (0)</td><td>1 (3)</td><td>0 (0)</td><td>18 (56)</td><td>4 (13)</td></tr><tr><td>Clinical perfectionism*</td><td>10 (36)</td><td>0 (0)</td><td>18 (64)</td><td>0 (0)</td><td>4 (13)</td><td>0 (0)</td><td>27 (84)</td><td>1 (3)</td></tr><tr><td>DASS depression</td><td>7 (25)</td><td>5 (18)</td><td>12 (43)</td><td>4 (14)</td><td>6 (19)</td><td>3 (9)</td><td>18 (56)</td><td>5 (16)</td></tr><tr><td>DASS anxiety</td><td>3 (11)</td><td>5 (18)</td><td>18 (64)</td><td>2 (7)</td><td>3 (9)</td><td>4 (13)</td><td>22 (69)</td><td>3 (9)</td></tr><tr><td>DASS stress*</td><td>3 (11)</td><td>9 (32)</td><td>14 (50)</td><td>2 (7)</td><td>0 (0)</td><td>6 (19)</td><td>22 (69)</td><td>4 (13)</td></tr></table>
1d461809df972c427fa7f0edac4e403be66d99f49642a1f0f0ffa583ae6d6afc.png
complex
<table><tr><td></td><td colspan="3">Dietary Group 2</td><td></td></tr><tr><td>Index</td><td>C</td><td>LP</td><td>R</td><td>SEM</td></tr><tr><td colspan="5">Day 3</td></tr><tr><td>Initial body weight (g/mouse)</td><td>8.5</td><td>8.4</td><td>8.6</td><td>0.10</td></tr><tr><td>Final body weight (g/mouse)</td><td>10.4 <sup>X</sup></td><td>7.2 <sup>Y</sup></td><td>7.4 <sup>Y</sup></td><td>0.10</td></tr><tr><td>Food intake (g/mouse &#183; 3d) 3</td><td>7.8 <sup>X</sup></td><td>4.5 <sup>Y</sup></td><td>3.6 <sup>Y</sup></td><td>0.20</td></tr><tr><td>Food intake (g/g body weight &#183; d)3</td><td>0.19 <sup>X</sup></td><td>0.13 <sup>Y</sup></td><td>0.09 <sup>Z</sup></td><td>0.001</td></tr><tr><td>Carcass dry matter (g/100g wet weight)</td><td>30.3 <sup>X</sup></td><td>28.3 <sup>Y</sup></td><td>27.9 <sup>Y</sup></td><td>0.30</td></tr><tr><td>Carcass lipid (g/100g wet weight)4</td><td>9.2 <sup>X</sup></td><td>5.9 <sup>Y</sup></td><td>3.4 <sup>Z</sup></td><td>0.03</td></tr><tr><td colspan="5">Day 14</td></tr><tr><td>Initial body weight (g/mouse)</td><td>8.3</td><td>8.5</td><td>8.6</td><td>0.08</td></tr><tr><td>Final body weight (g/mouse) 4</td><td>17.5 <sup>X</sup></td><td>6.1 <sup>Y</sup></td><td>6.0 <sup>Y</sup></td><td>0.02</td></tr><tr><td>Food intake (g/mouse &#183; 14d) 5</td><td>60.6 <sup>X</sup></td><td>18.2 <sup>Y</sup></td><td>12.6 <sup>Z</sup></td><td>0.01</td></tr><tr><td>Food intake (g/g body weight &#183; d)</td><td>0.20 <sup>X</sup></td><td>0.11 <sup>Y</sup></td><td>0.08 <sup>Z</sup></td><td>0.002</td></tr><tr><td>Carcass dry matter (g/100g wet weight)</td><td>32.1 <sup>X</sup></td><td>28.1 <sup>Y</sup></td><td>26.5 <sup>Z</sup></td><td>0.26</td></tr><tr><td>Carcass lipid (g/100g wet weight)</td><td>10.4 <sup>X</sup></td><td>4.5 <sup>Y</sup></td><td>2.7 <sup>Z</sup></td><td>0.34</td></tr></table>
<table><tr><td></td><td colspan="3">Dietary Group 2</td><td></td></tr><tr><td>Index</td><td>C</td><td>LP</td><td>R</td><td>SEM</td></tr></table>
<table><tr><td colspan="5">Day 3</td></tr><tr><td>Initial body weight (g/mouse)</td><td>8.5</td><td>8.4</td><td>8.6</td><td>0.10</td></tr><tr><td>Final body weight (g/mouse)</td><td>10.4 X</td><td>7.2 Y</td><td>7.4 Y</td><td>0.10</td></tr><tr><td>Food intake (g/mouse · 3d) 3</td><td>7.8 X</td><td>4.5 Y</td><td>3.6 Y</td><td>0.20</td></tr><tr><td>Food intake (g/g body weight · d)3</td><td>0.19 X</td><td>0.13 Y</td><td>0.09 Z</td><td>0.001</td></tr><tr><td>Carcass dry matter (g/100g wet weight)</td><td>30.3 X</td><td>28.3 Y</td><td>27.9 Y</td><td>0.30</td></tr><tr><td>Carcass lipid (g/100g wet weight)4</td><td>9.2 X</td><td>5.9 Y</td><td>3.4 Z</td><td>0.03</td></tr><tr><td colspan="5">Day 14</td></tr><tr><td>Initial body weight (g/mouse)</td><td>8.3</td><td>8.5</td><td>8.6</td><td>0.08</td></tr><tr><td>Final body weight (g/mouse) 4</td><td>17.5 X</td><td>6.1 Y</td><td>6.0 Y</td><td>0.02</td></tr><tr><td>Food intake (g/mouse · 14d) 5</td><td>60.6 X</td><td>18.2 Y</td><td>12.6 Z</td><td>0.01</td></tr><tr><td>Food intake (g/g body weight · d)</td><td>0.20 X</td><td>0.11 Y</td><td>0.08 Z</td><td>0.002</td></tr><tr><td>Carcass dry matter (g/100g wet weight)</td><td>32.1 X</td><td>28.1 Y</td><td>26.5 Z</td><td>0.26</td></tr><tr><td>Carcass lipid (g/100g wet weight)</td><td>10.4 X</td><td>4.5 Y</td><td>2.7 Z</td><td>0.34</td></tr></table>
15f57f23637b95ce6f170f04a1151bb7ec13ebfd54517432a8b6630d8c9506cc.png
complex
<table><tr><td></td><td colspan="3">rs3782886</td><td><i>p</i> for trend</td><td>Minor allele frequencies</td></tr><tr><td></td><td colspan="2">Non-minor homo</td><td>Minor homo</td><td></td><td></td></tr><tr><td></td><td>Major homo (A/A)</td><td>Hetero (A/G)</td><td>(G/G)</td><td></td><td></td></tr><tr><td colspan="6">Short stature</td></tr><tr><td colspan="6"> Total participants (BMI &lt; 25 kg/m<sup>2</sup>)</td></tr><tr><td>No. at risk</td><td>232</td><td>123</td><td>17</td><td></td><td></td></tr><tr><td>No. of cases (percentage)</td><td>56 (24.1)</td><td>30 (24.4)</td><td>9 (52.9)</td><td></td><td></td></tr><tr><td rowspan="2">Model 1</td><td>1.00</td><td>0.96 (0.55, 1.68)</td><td>4.18 (1.37, 12.75)</td><td>0.127</td><td>1.39 (0.91, 2.13)</td></tr><tr><td colspan="2">1.00</td><td>4.23 (1.41, 12.72)</td><td>0.010</td><td></td></tr><tr><td rowspan="2">Model 2</td><td>1.00</td><td>1.03 (0.57, 1.86)</td><td>4.25 (1.35, 13.39)</td><td>0.092</td><td>1.47 (0.94, 2.31)</td></tr><tr><td colspan="2">1.00</td><td>4.21 (1.36, 12.98)</td><td>0.012</td><td></td></tr><tr><td colspan="6">Reduced maximum voluntary tongue pressure against the palate (MTP)</td></tr><tr><td colspan="6"> Total participants (BMI &lt; 25 kg/m<sup>2</sup>)</td></tr><tr><td>No. at risk</td><td>232</td><td>123</td><td>17</td><td></td><td></td></tr><tr><td>No. of cases (percentage)</td><td>82 (35.3)</td><td>44 (35.8)</td><td>11 (64.7)</td><td></td><td></td></tr><tr><td rowspan="2">Model 1</td><td>1.00</td><td>1.00 (0.62, 1.61)</td><td>3.56 (1.21, 10.53)</td><td>0.149</td><td>1.32 (0.91, 1.92)</td></tr><tr><td colspan="2">1.00</td><td>3.57 (1.22, 10.43)</td><td>0.020</td><td></td></tr><tr><td rowspan="2">Model 2</td><td>1.00</td><td>1.11 (0.66, 1.86)</td><td>4.49 (1.45, 13.92)</td><td>0.054</td><td>1.49 (0.99, 2.24)</td></tr><tr><td colspan="2">1.00</td><td>4.31 (1.41, 13.11)</td><td>0.010</td><td></td></tr></table>
<table><tr><td></td><td colspan="2">rs3782886</td></tr><tr><td></td><td colspan="2">Non-minor homo</td></tr><tr><td></td><td>Major homo (A/A)</td><td>Hetero (A/G)</td></tr><tr><td colspan="3">Short stature</td></tr><tr><td colspan="3">Total participants (BMI < 25 kg/m2)</td></tr><tr><td>No. at risk</td><td>232</td><td>123</td></tr><tr><td>No. of cases (percentage)</td><td>56 (24.1)</td><td>30 (24.4)</td></tr><tr><td rowspan="2">Model 1</td><td>1.00</td><td>0.96 (0.55, 1.68)</td></tr><tr><td colspan="2">1.00</td></tr><tr><td rowspan="2">Model 2</td><td>1.00</td><td>1.03 (0.57, 1.86)</td></tr><tr><td colspan="2">1.00</td></tr><tr><td colspan="3">Reduced maximum voluntary tongue pressure against the palate (MTP)</td></tr><tr><td colspan="3">Total participants (BMI < 25 kg/m2)</td></tr><tr><td>No. at risk</td><td>232</td><td>123</td></tr><tr><td>No. of cases (percentage)</td><td>82 (35.3)</td><td>44 (35.8)</td></tr><tr><td rowspan="2">Model 1</td><td>1.00</td><td>1.00 (0.62, 1.61)</td></tr><tr><td colspan="2">1.00</td></tr><tr><td rowspan="2">Model 2</td><td>1.00</td><td>1.11 (0.66, 1.86)</td></tr><tr><td colspan="2">1.00</td></tr></table>
<table><tr><td>rs3782886</td><td>p for trend</td><td>Minor allele frequencies</td></tr><tr><td>Minor homo</td><td></td><td></td></tr><tr><td>(G/G)</td><td></td><td></td></tr><tr><td colspan="3">Short stature</td></tr><tr><td colspan="3">Total participants (BMI < 25 kg/m2)</td></tr><tr><td>17</td><td></td><td></td></tr><tr><td>9 (52.9)</td><td></td><td></td></tr><tr><td>4.18 (1.37, 12.75)</td><td>0.127</td><td>1.39 (0.91, 2.13)</td></tr><tr><td>4.23 (1.41, 12.72)</td><td>0.010</td><td></td></tr><tr><td>4.25 (1.35, 13.39)</td><td>0.092</td><td>1.47 (0.94, 2.31)</td></tr><tr><td>4.21 (1.36, 12.98)</td><td>0.012</td><td></td></tr><tr><td colspan="3">Reduced maximum voluntary tongue pressure against the palate (MTP)</td></tr><tr><td colspan="3">Total participants (BMI < 25 kg/m2)</td></tr><tr><td>17</td><td></td><td></td></tr><tr><td>11 (64.7)</td><td></td><td></td></tr><tr><td>3.56 (1.21, 10.53)</td><td>0.149</td><td>1.32 (0.91, 1.92)</td></tr><tr><td>3.57 (1.22, 10.43)</td><td>0.020</td><td></td></tr><tr><td>4.49 (1.45, 13.92)</td><td>0.054</td><td>1.49 (0.99, 2.24)</td></tr><tr><td>4.31 (1.41, 13.11)</td><td>0.010</td><td></td></tr></table>
304580be39634358a70ebd056a07b7cde7c361ba3cde80c94c632540ba68126e.png
simple
<table><tr><td>Case</td><td>Fusion</td><td>mit.</td><td>CD34</td><td>CD99</td><td>EMA</td><td>SMA</td><td>S100</td><td>BCL2</td><td>STAT6</td><td>EGR1</td><td>Others</td></tr><tr><td>1</td><td>Ex4-Ex3</td><td>8/10</td><td>+</td><td>+</td><td>-</td><td>-</td><td>-</td><td>+</td><td>+</td><td>1</td><td>desmine -</td></tr><tr><td>2</td><td>Positive</td><td>3/10</td><td>+</td><td>+</td><td></td><td>+</td><td>+</td><td>+</td><td>+</td><td>3</td><td>desmine -, CK-pan -</td></tr><tr><td>3</td><td>Ex4-Ex3</td><td>3/10</td><td>+</td><td></td><td></td><td>-</td><td></td><td>+</td><td>+</td><td>1</td><td>desmine -</td></tr><tr><td>4</td><td>Negative</td><td>0/10</td><td>-</td><td>+</td><td>-</td><td>+</td><td>-</td><td>+</td><td>+</td><td>1</td><td>desmine -</td></tr><tr><td>5</td><td>Ex4-Ex3</td><td>0/10</td><td>+</td><td>+</td><td></td><td>-</td><td>-</td><td>+</td><td>+</td><td>1</td><td>desmine -, CK-pan -</td></tr><tr><td>6</td><td>Ex4-Ex3</td><td>4/10</td><td>+</td><td>w+</td><td></td><td></td><td>-</td><td>+</td><td>+</td><td>2</td><td>CK-pan +</td></tr><tr><td>7</td><td>Negative</td><td>1/10</td><td>+</td><td>+</td><td>-</td><td>-</td><td>-</td><td>+</td><td>+</td><td>5</td><td>CK-pan -</td></tr><tr><td>8</td><td>Positive</td><td>0/10</td><td>+</td><td>+</td><td></td><td>-</td><td></td><td>+</td><td>+</td><td>2</td><td>CK-pan -</td></tr><tr><td>9</td><td>Ex7-Ex3</td><td>0/10</td><td>+</td><td>+</td><td></td><td></td><td></td><td>+</td><td>+</td><td>2</td><td>CK-pan -</td></tr><tr><td>10</td><td>Negative</td><td>1/10</td><td>+</td><td>+</td><td>-</td><td>-</td><td>-</td><td>+</td><td>+</td><td>3</td><td>desmine -, CK-pan -</td></tr><tr><td>11</td><td>Negative</td><td>0/10</td><td>+</td><td>+</td><td></td><td>-</td><td>-</td><td>+</td><td>+</td><td>2</td><td>desmine -, CK-pan -</td></tr><tr><td>12</td><td>Ex4-Ex3</td><td>1/10</td><td>+</td><td></td><td></td><td></td><td></td><td>+</td><td>+</td><td>4</td><td>desmine -</td></tr><tr><td>13</td><td>Negative</td><td>0/10</td><td>+</td><td>+</td><td>f+</td><td>-</td><td>-</td><td>+</td><td>+</td><td>3</td><td>desmine -</td></tr><tr><td>14</td><td>Ex4-Ex3</td><td>0/10</td><td>+</td><td>+</td><td></td><td></td><td></td><td>+</td><td>+</td><td>1</td><td></td></tr><tr><td>15</td><td>Ex4-Ex3</td><td>0/10</td><td>+</td><td>+</td><td></td><td>-</td><td>-</td><td>w+</td><td>+</td><td>NA</td><td></td></tr><tr><td>16</td><td>Ex6-Ex17</td><td>30/10</td><td>+</td><td>+</td><td></td><td></td><td></td><td>+</td><td>+</td><td>3</td><td>desmine -</td></tr><tr><td>17</td><td>Ex6-Ex18</td><td>13/10</td><td>+</td><td>+</td><td>-</td><td></td><td>-</td><td>+</td><td>+</td><td>1</td><td>desmine -, CK-pan -</td></tr><tr><td>18</td><td>Ex4-Ex3</td><td>0/10</td><td>+</td><td></td><td></td><td>-</td><td>-</td><td>+</td><td>+</td><td>2</td><td>desmine f+, CK-pan -</td></tr><tr><td>19</td><td>Ex4-Ex3</td><td>0/10</td><td>+</td><td></td><td></td><td>-</td><td>-</td><td></td><td>+</td><td>1</td><td>desmine -</td></tr><tr><td>20</td><td>Negative</td><td>1/10</td><td>+</td><td></td><td></td><td>-</td><td>-</td><td></td><td>+</td><td>1</td><td>desmine -, CK-pan -</td></tr><tr><td>21</td><td>Ex6-Ex18</td><td>0/10</td><td>+</td><td></td><td></td><td></td><td></td><td>+</td><td>+</td><td>1</td><td></td></tr><tr><td>22</td><td>Ex6-Ex3</td><td>0/10</td><td>+</td><td></td><td></td><td>w+</td><td>-</td><td></td><td>+</td><td>1</td><td>desmine -</td></tr><tr><td>23</td><td>Ex4-Ex3</td><td>8/10</td><td>+</td><td>+</td><td></td><td>-</td><td>-</td><td>+</td><td>+</td><td>1</td><td>desmine -</td></tr><tr><td>24</td><td>Negative</td><td>1/10</td><td>+</td><td>+</td><td></td><td></td><td></td><td>+</td><td>+</td><td>3</td><td>desmine -, CK-pan -</td></tr><tr><td>25</td><td>Ex4-Ex3</td><td>1/10</td><td>+</td><td></td><td></td><td></td><td></td><td></td><td>+</td><td>1</td><td></td></tr><tr><td>26</td><td>NA</td><td>0/10</td><td>+</td><td></td><td></td><td></td><td></td><td></td><td>+</td><td>5</td><td></td></tr><tr><td>27</td><td>Ex6-Ex18</td><td>0/10</td><td>+</td><td></td><td></td><td></td><td></td><td></td><td>+</td><td>2</td><td></td></tr><tr><td>28</td><td>NA</td><td>6/10</td><td>+</td><td>-</td><td></td><td></td><td>-</td><td></td><td>+</td><td>5</td><td>desmine -, CK-pan -</td></tr></table>
<table><tr><td>Case</td><td>Fusion</td><td>mit.</td><td>CD34</td><td>CD99</td><td>EMA</td><td>SMA</td><td>S100</td><td>BCL2</td><td>STAT6</td><td>EGR1</td><td>Others</td></tr><tr><td>1</td><td>Ex4-Ex3</td><td>8/10</td><td>+</td><td>+</td><td>-</td><td>-</td><td>-</td><td>+</td><td>+</td><td>1</td><td>desmine -</td></tr><tr><td>2</td><td>Positive</td><td>3/10</td><td>+</td><td>+</td><td></td><td>+</td><td>+</td><td>+</td><td>+</td><td>3</td><td>desmine -, CK-pan -</td></tr><tr><td>3</td><td>Ex4-Ex3</td><td>3/10</td><td>+</td><td></td><td></td><td>-</td><td></td><td>+</td><td>+</td><td>1</td><td>desmine -</td></tr><tr><td>4</td><td>N</td><td>0/</td><td></td><td></td><td>-</td><td>+</td><td></td><td></td><td>+</td><td>1</td><td>des</td></tr></table>
<table><tr><td></td><td>egative</td><td>10</td><td>-</td><td>+</td><td></td><td></td><td>-</td><td>+</td><td></td><td></td><td>mine -</td></tr><tr><td>5</td><td>Ex4-Ex3</td><td>0/10</td><td>+</td><td>+</td><td></td><td>-</td><td>-</td><td>+</td><td>+</td><td>1</td><td>desmine -, CK-pan -</td></tr><tr><td>6</td><td>Ex4-Ex3</td><td>4/10</td><td>+</td><td>w+</td><td></td><td></td><td>-</td><td>+</td><td>+</td><td>2</td><td>CK-pan +</td></tr><tr><td>7</td><td>Negative</td><td>1/10</td><td>+</td><td>+</td><td>-</td><td>-</td><td>-</td><td>+</td><td>+</td><td>5</td><td>CK-pan -</td></tr><tr><td>8</td><td>Positive</td><td>0/10</td><td>+</td><td>+</td><td></td><td>-</td><td></td><td>+</td><td>+</td><td>2</td><td>CK-pan -</td></tr><tr><td>9</td><td>Ex7-Ex3</td><td>0/10</td><td>+</td><td>+</td><td></td><td></td><td></td><td>+</td><td>+</td><td>2</td><td>CK-pan -</td></tr><tr><td>10</td><td>Negative</td><td>1/10</td><td>+</td><td>+</td><td>-</td><td>-</td><td>-</td><td>+</td><td>+</td><td>3</td><td>desmine -, CK-pan -</td></tr><tr><td>11</td><td>Negative</td><td>0/10</td><td>+</td><td>+</td><td></td><td>-</td><td>-</td><td>+</td><td>+</td><td>2</td><td>desmine -, CK-pan -</td></tr><tr><td>12</td><td>Ex4-Ex3</td><td>1/10</td><td>+</td><td></td><td></td><td></td><td></td><td>+</td><td>+</td><td>4</td><td>desmine -</td></tr><tr><td>13</td><td>Negative</td><td>0/10</td><td>+</td><td>+</td><td>f+</td><td>-</td><td>-</td><td>+</td><td>+</td><td>3</td><td>desmine -</td></tr><tr><td>14</td><td>Ex4-Ex3</td><td>0/10</td><td>+</td><td>+</td><td></td><td></td><td></td><td>+</td><td>+</td><td>1</td><td></td></tr><tr><td>15</td><td>Ex4-Ex3</td><td>0/10</td><td>+</td><td>+</td><td></td><td>-</td><td>-</td><td>w+</td><td>+</td><td>NA</td><td></td></tr><tr><td>16</td><td>Ex6-Ex17</td><td>30/10</td><td>+</td><td>+</td><td></td><td></td><td></td><td>+</td><td>+</td><td>3</td><td>desmine -</td></tr><tr><td>17</td><td>Ex6-Ex18</td><td>13/10</td><td>+</td><td>+</td><td>-</td><td></td><td>-</td><td>+</td><td>+</td><td>1</td><td>desmine -, CK-pan -</td></tr><tr><td>18</td><td>Ex4-Ex3</td><td>0/10</td><td>+</td><td></td><td></td><td>-</td><td>-</td><td>+</td><td>+</td><td>2</td><td>desmine f+, CK-pan -</td></tr><tr><td>19</td><td>Ex4-Ex3</td><td>0/10</td><td>+</td><td></td><td></td><td>-</td><td>-</td><td></td><td>+</td><td>1</td><td>desmine -</td></tr><tr><td>20</td><td>Negative</td><td>1/10</td><td>+</td><td></td><td></td><td>-</td><td>-</td><td></td><td>+</td><td>1</td><td>desmine -, CK-pan -</td></tr><tr><td>21</td><td>Ex6-Ex18</td><td>0/10</td><td>+</td><td></td><td></td><td></td><td></td><td>+</td><td>+</td><td>1</td><td></td></tr><tr><td>22</td><td>Ex6-Ex3</td><td>0/10</td><td>+</td><td></td><td></td><td>w+</td><td>-</td><td></td><td>+</td><td>1</td><td>desmine -</td></tr><tr><td>23</td><td>Ex4-Ex3</td><td>8/10</td><td>+</td><td>+</td><td></td><td>-</td><td>-</td><td>+</td><td>+</td><td>1</td><td>desmine -</td></tr><tr><td>24</td><td>Negative</td><td>1/10</td><td>+</td><td>+</td><td></td><td></td><td></td><td>+</td><td>+</td><td>3</td><td>desmine -, CK-pan -</td></tr><tr><td>25</td><td>Ex4-Ex3</td><td>1/10</td><td>+</td><td></td><td></td><td></td><td></td><td></td><td>+</td><td>1</td><td></td></tr><tr><td>26</td><td>NA</td><td>0/10</td><td>+</td><td></td><td></td><td></td><td></td><td></td><td>+</td><td>5</td><td></td></tr><tr><td>27</td><td>Ex6-Ex18</td><td>0/10</td><td>+</td><td></td><td></td><td></td><td></td><td></td><td>+</td><td>2</td><td></td></tr><tr><td>28</td><td>NA</td><td>6/10</td><td>+</td><td>-</td><td></td><td></td><td>-</td><td></td><td>+</td><td>5</td><td>desmine -, CK-pan -</td></tr></table>
84c3dde9ea208d29e248de6679377716a65e2024b34e05605c3901a70c2fb69f.png
simple
<table><tr><td>Study (Year)Location<i>Review article cited</i></td><td>Nature of Practice</td><td>Amount of Practice</td><td>Study Results, Attributes and Limitations </td></tr><tr><td>IWAO et al. (1999) [51]Japan/Kyoto<i>uncontrolled observational study</i></td><td>Qigong walking = mild and slow walking using all muscles in body Conventional walking = normal walking</td><td>Evaluated 90 min post lunch on 3 different days Qigong walking (30&#8211;40 min)Conventional walking (30 min)</td><td>Plasma glucose decreased in both exercise groups Conventional = 228 to 205 mg/dL; Qigong = 223 to 216 mg/dLCompared with no exercise, 229 mg/dL (<i>p</i> &lt; 0.025)<i>Very short-duration study where subjects served as their own controls. Little information known about subjects.</i></td></tr><tr><td>LIU et al. (2010) [52]Australia/Queensland<i>Pre-post feasibility trial uncontrolled observational study</i></td><td>Kai/Mai Tai Chi/Qigong style - defines qigong as "mind-body movement therapy...most involve combined training of movement, breathing, and mind, with a strong focus on the mind&#8220;</td><td>12 weeks1&#8211;1.5 h 3&#215;/wk with Tai Chi/Qigong instructor; also encouraged to practice at home</td><td>Good adherence and high acceptability; Significant reductions with BMI, HbA1c and IR<i>No subjects were taking medications. Combination of group and individual practice.</i></td></tr><tr><td>HUANG et al. (2012) [53]Taiwan/Kaohsiung<i>quasi-experimental</i></td><td>Defines qigong as breathing training. Qi meaning breath and gong meaning to train. Five Element Gymnastics (FEG) consolidates Qigong, Xiang Gong &amp; Martial Arts with Gymnastics.</td><td>16 weeksFEG practiced following DVD 2 &#215;/day for 20 min each session for 16 weeks with 2 sessions in first week taught by certified fitness instructor and group education sessions at weeks 3, 7, 11 and 14; Control group maintained usual activities</td><td>HbA1C change -6.77 (<i>p</i> &lt; 0.01)<i>Included insulin-dependent subjects; however, medications remained same. Combination of instructor led group practice and DVD led at home individual practice.</i></td></tr></table>
<table><tr><td>Study (Year)LocationReview article cited</td><td>Nature of Practice</td></tr><tr><td>IWAO et al. (1999) [51]Japan/Kyotouncontrolled observational study</td><td>Qigong walking = mild and slow walking using all muscles in body Conventional walking = normal walking</td></tr><tr><td>LIU et al. (2010) [52]Australia/QueenslandPre-post feasibility trial uncontrolled observational study</td><td>Kai/Mai Tai Chi/Qigong style - defines qigong as "mind-body movement therapy...most involve combined training of movement, breathing, and mind, with a strong focus on the mind“</td></tr><tr><td>HUANG et al. (2012) [53]Taiwan/Kaohsiungquasi-experimental</td><td>Defines qigong as breathing training. Qi meaning breath and gong meaning to train. Five Element Gymnastics (FEG) consolidates Qigong, Xiang Gong & Martial Arts with Gymnastics.</td></tr></table>
<table><tr><td>Amount of Practice</td><td>Study Results, Attributes and Limitations</td></tr><tr><td>Evaluated 90 min post lunch on 3 different days Qigong walking (30–40 min)Conventional walking (30 min)</td><td>Plasma glucose decreased in both exercise groups Conventional = 228 to 205 mg/dL; Qigong = 223 to 216 mg/dLCompared with no exercise, 229 mg/dL (p < 0.025)Very short-duration study where subjects served as their own controls. Little information known about subjects.</td></tr><tr><td>12 weeks1–1.5 h 3×/wk with Tai Chi/Qigong instructor; also encouraged to practice at home</td><td>Good adherence and high acceptability; Significant reductions with BMI, HbA1c and IRNo subjects were taking medications. Combination of group and individual practice.</td></tr><tr><td>16 weeksFEG practiced following DVD 2 ×/day for 20 min each session for 16 weeks with 2 sessions in first week taught by certified fitness instructor and group education sessions at weeks 3, 7, 11 and 14; Control group maintained usual activities</td><td>HbA1C change -6.77 (p < 0.01)Included insulin-dependent subjects; however, medications remained same. Combination of instructor led group practice and DVD led at home individual practice.</td></tr></table>
a43f1797aa4c2a10c854132f836d493d5ae42878f3318d592dcc03346ec3680e.png
complex
<table><tr><td></td><td colspan="6">Categories of Alcohol Consumption</td><td></td></tr><tr><td></td><td>Never(n = 248)</td><td><i>Former</i>(<i>n </i>= 208)</td><td>0.1-10.0 g/d(n = 638)</td><td>10.1-20.0 g/d(n = 152)</td><td>20.1-40.0g/d (n = 114)</td><td>&gt; 40.0 g/d(n = 132)</td><td><i>p</i>&#182;</td></tr><tr><td>CCA-IMT, mm</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> Age-adjusted</td><td>0.805 &#177; 0.009</td><td><i>0.778 &#177; 0.010*</i></td><td>0.775 &#177; 0.006**</td><td>0.773 &#177; 0.012*</td><td>0.770 &#177; 0.014*</td><td>0.769 &#177; 0.013*</td><td>0.028</td></tr><tr><td> Multivariate-adjusted&#8224;</td><td>0.814 &#177; 0.009</td><td><i>0.782 &#177; 0.010*</i></td><td>0.776 &#177; 0.006**</td><td>0.767 &#177; 0.012**</td><td>0.756 &#177; 0.013**</td><td>0.758 &#177; 0.013**</td><td>&lt; 0.001</td></tr><tr><td> Multivariate-adjusted+HDL&#8225;</td><td>0.811 &#177; 0.009</td><td><i>0.778 &#177; 0.010*</i></td><td>0.775 &#177; 0.006**</td><td>0.769 &#177; 0.012**</td><td>0.762 &#177; 0.013**</td><td>0.769 &#177; 0.013**</td><td>0.009</td></tr><tr><td>CB-IMT, mm</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> Age-adjusted</td><td>0.868 &#177; 0.008</td><td><i>0.848 &#177; 0.009</i></td><td>0.843 &#177; 0.005**</td><td>0.842 &#177; 0.011*</td><td>0.850 &#177; 0.012</td><td>0.827 &#177; 0.011**</td><td>0.018</td></tr><tr><td> Multivariate-adjusted&#8224;</td><td>0.874 &#177; 0.008</td><td><i>0.852 &#177; 0.009</i></td><td>0.843 &#177; 0.005**</td><td>0.839 &#177; 0.010**</td><td>0.841 &#177; 0.012*</td><td>0.821 &#177; 0.011**</td><td>0.001</td></tr><tr><td> Multivariate-adjusted+HDL&#8225;</td><td>0.871 &#177; 0.008</td><td><i>0.848 &#177; 0.009</i></td><td>0.842 &#177; 0.005**</td><td>0.841 &#177; 0.010*</td><td>0.847 &#177; 0.012</td><td>0.832 &#177; 0.012**</td><td>0.038</td></tr><tr><td>Higher CCA-IMT&#167;</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> Prevalence, %</td><td>27.8</td><td>24.5</td><td>19.1</td><td>17.1</td><td>16.7</td><td>12.1</td><td>&lt; 0.001</td></tr><tr><td> Age-adjusted</td><td>1</td><td>0.83 (<i>0.54-1.28</i>)</td><td>0.72 (0.51-1.03)</td><td>0.64 (0.38-1.08)</td><td>0.64 (0.36-1.14)</td><td>0.47 (0.26-0.85)*</td><td>0.007</td></tr><tr><td> Multivariate-adjusted&#8224;</td><td>1</td><td>0.78 (<i>0.50-1.22</i>)</td><td>0.68 (0.47-0.98)*</td><td>0.56 (0.32-0.95)*</td><td>0.50 (0.28-0.92)*</td><td>0.38 (0.20-0.71)*</td><td>0.001</td></tr><tr><td> Multivariate-adjusted+HDL&#8225;</td><td>1</td><td>0.78 (<i>0.49-1.22</i>)</td><td>0.68 (0.47-0.99)*</td><td>0.57 (0.33-0.98)*</td><td>0.53 (0.29-0.98)*</td><td>0.41 (0.21-0.78)*</td><td>0.004</td></tr></table>
<table><tr><td></td></tr><tr><td></td></tr><tr><td>CCA-IMT, mm</td></tr><tr><td>Age-adjusted</td></tr><tr><td>Multivariate-adjusted†</td></tr><tr><td>Multivariate-adjusted+HDL‡</td></tr><tr><td>CB-IMT, mm</td></tr><tr><td>Age-adjusted</td></tr><tr><td>Multivariate-adjusted†</td></tr><tr><td>Multivariate-adjusted+HDL‡</td></tr><tr><td>Higher CCA-IMT§</td></tr><tr><td>Prevalence, %</td></tr><tr><td>Age-adjusted</td></tr><tr><td>Multivariate-adjusted†</td></tr><tr><td>Multivariate-adjusted+HDL‡</td></tr></table>
<table><tr><td colspan="6">Categories of Alcohol Consumption</td><td></td></tr><tr><td>Never(n = 248)</td><td>Former(n = 208)</td><td>0.1-10.0 g/d(n = 638)</td><td>10.1-20.0 g/d(n = 152)</td><td>20.1-40.0g/d (n = 114)</td><td>> 40.0 g/d(n = 132)</td><td>p¶</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>0.805 ± 0.009</td><td>0.778 ± 0.010*</td><td>0.775 ± 0.006**</td><td>0.773 ± 0.012*</td><td>0.770 ± 0.014*</td><td>0.769 ± 0.013*</td><td>0.028</td></tr><tr><td>0.814 ± 0.009</td><td>0.782 ± 0.010*</td><td>0.776 ± 0.006**</td><td>0.767 ± 0.012**</td><td>0.756 ± 0.013**</td><td>0.758 ± 0.013**</td><td>< 0.001</td></tr><tr><td>0.811 ± 0.009</td><td>0.778 ± 0.010*</td><td>0.775 ± 0.006**</td><td>0.769 ± 0.012**</td><td>0.762 ± 0.013**</td><td>0.769 ± 0.013**</td><td>0.009</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>0.868 ± 0.008</td><td>0.848 ± 0.009</td><td>0.843 ± 0.005**</td><td>0.842 ± 0.011*</td><td>0.850 ± 0.012</td><td>0.827 ± 0.011**</td><td>0.018</td></tr><tr><td>0.874 ± 0.008</td><td>0.852 ± 0.009</td><td>0.843 ± 0.005**</td><td>0.839 ± 0.010**</td><td>0.841 ± 0.012*</td><td>0.821 ± 0.011**</td><td>0.001</td></tr><tr><td>0.871 ± 0.008</td><td>0.848 ± 0.009</td><td>0.842 ± 0.005**</td><td>0.841 ± 0.010*</td><td>0.847 ± 0.012</td><td>0.832 ± 0.012**</td><td>0.038</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>27.8</td><td>24.5</td><td>19.1</td><td>17.1</td><td>16.7</td><td>12.1</td><td>< 0.001</td></tr><tr><td>1</td><td>0.83 (0.54-1.28)</td><td>0.72 (0.51-1.03)</td><td>0.64 (0.38-1.08)</td><td>0.64 (0.36-1.14)</td><td>0.47 (0.26-0.85)*</td><td>0.007</td></tr><tr><td>1</td><td>0.78 (0.50-1.22)</td><td>0.68 (0.47-0.98)*</td><td>0.56 (0.32-0.95)*</td><td>0.50 (0.28-0.92)*</td><td>0.38 (0.20-0.71)*</td><td>0.001</td></tr><tr><td>1</td><td>0.78 (0.49-1.22)</td><td>0.68 (0.47-0.99)*</td><td>0.57 (0.33-0.98)*</td><td>0.53 (0.29-0.98)*</td><td>0.41 (0.21-0.78)*</td><td>0.004</td></tr></table>
0c7c370ae9c0e83c567dac66b89b4e3e258cd628939c48a6a58724677671e61e.png
simple
<table><tr><td>Name</td><td>Expression plasmids</td><td>Properties</td></tr><tr><td>YJ0</td><td>pBS01A</td><td>Empty vector</td></tr><tr><td>YJ-G01</td><td>pYJ-G01</td><td><i>TcGPAT1</i> expression</td></tr><tr><td>YJ-G02</td><td>pYJ-G02</td><td><i>TcGPAT2</i> expression</td></tr><tr><td>YJ-L01</td><td>pYJ-L01</td><td><i>TcLPAT1</i> expression</td></tr><tr><td>YJ-L02</td><td>pYJ-L02</td><td><i>TcLPAT2</i> expression</td></tr><tr><td>YJ-D01</td><td>pYJ-D01</td><td><i>TcDGAT1</i> expression</td></tr><tr><td>YJ-D02</td><td>pYJ-D02</td><td><i>TcDGAT2</i> expression</td></tr><tr><td>YJ-111</td><td>pYJ-111</td><td><i>TcGPAT1</i>, <i>TcLPAT1</i> and <i>TcDGAT1</i> gene combination expression</td></tr><tr><td>YJ-112</td><td>pYJ-112</td><td><i>TcGPAT1</i>, <i>TcLPAT1</i> and <i>TcDGAT2</i> gene combination expression</td></tr><tr><td>YJ-121</td><td>pYJ-121</td><td><i>TcGPAT1</i>, <i>TcLPAT2</i> and <i>TcDGAT1</i> gene combination expression</td></tr><tr><td>YJ-122</td><td>pYJ-122</td><td><i>TcGPAT1</i>, <i>TcLPAT2</i> and <i>TcDGAT2</i> gene combination expression</td></tr><tr><td>YJ-211</td><td>pYJ-211</td><td><i>TcGPAT2</i>, <i>TcLPAT1</i> and <i>TcDGAT1</i> gene combination expression</td></tr><tr><td>YJ-212</td><td>pYJ-212</td><td><i>TcGPAT2</i>, <i>TcLPAT1</i> and <i>TcDGAT2</i> gene combination expression</td></tr><tr><td>YJ-221</td><td>pYJ-221</td><td><i>TcGPAT2</i>, <i>TcLPAT2</i> and <i>TcDGAT1</i> gene combination expression</td></tr><tr><td>YJ-222</td><td>pYJ-222</td><td><i>TcGPAT2</i>, <i>TcLPAT2</i> and <i>TcDGAT2</i> gene combination expression</td></tr></table>
<table><tr><td>Name</td><td>Expression plasmids</td><td>Properties</td></tr><tr><td>YJ0</td><td>pBS01A</td><td>Empty vector</td></tr><tr><td>YJ-G01</td><td>pYJ-G01</td><td>TcGPAT1 expression</td></tr><tr><td>YJ-G02</td><td>pYJ-G02</td><td>TcGPAT2 expression</td></tr><tr><td>YJ-L01</td><td>pYJ-L01</td><td>TcLPAT1 expression</td></tr><tr><td>YJ-L02</td><td>pYJ-L02</td><td>TcLPAT2 expression</td></tr><tr><td>YJ-D01</td><td>pYJ-D01</td><td>TcDGAT1 expression</td></tr><tr><td>YJ-D02</td><td>pYJ-D02</td><td>TcDGAT2 expression</td></tr><tr><td>YJ-111</td><td>pYJ-111</td><td>TcGPAT1, TcLPAT1 and TcDGAT1 gene combination expression</td></tr><tr><td>YJ-112</td><td>pYJ-112</td><td>TcGPAT1, TcLPAT1 and TcDGAT2 gene combination expression</td></tr><tr><td>YJ-121</td><td>pYJ-121</td><td>TcGPAT1, TcLPAT2 and TcDGAT1 gene combination expression</td></tr></table>
<table><tr><td>Name</td><td>Expression plasmids</td><td>Properties</td></tr><tr><td>YJ-122</td><td>pYJ-122</td><td>TcGPAT1, TcLPAT2 and TcDGAT2 gene combination expression</td></tr><tr><td>YJ-211</td><td>pYJ-211</td><td>TcGPAT2, TcLPAT1 and TcDGAT1 gene combination expression</td></tr><tr><td>YJ-212</td><td>pYJ-212</td><td>TcGPAT2, TcLPAT1 and TcDGAT2 gene combination expression</td></tr><tr><td>YJ-221</td><td>pYJ-221</td><td>TcGPAT2, TcLPAT2 and TcDGAT1 gene combination expression</td></tr><tr><td>YJ-222</td><td>pYJ-222</td><td>TcGPAT2, TcLPAT2 and TcDGAT2 gene combination expression</td></tr></table>
348d126b89143c70ce3e8cf36ba743213d5fc5371476e6c8b2f2e6f2fdaa2f4c.png
simple
<table><tr><td>Variable</td><td>Sensitivity</td><td>Specificity</td><td>Positive predictive value</td><td>Negative predictive value</td></tr><tr><td>B3 criterion</td><td>0.44</td><td>0.91</td><td>0.13</td><td>0.87</td></tr><tr><td>MSI histology</td><td>0.79</td><td>0.85</td><td>0.20</td><td>0.80</td></tr><tr><td>MsPath score*</td><td>0.86</td><td>0.85</td><td>0.18</td><td>0.82</td></tr><tr><td>Tumor infiltrating lymphocytes</td><td>0.52</td><td>0.65</td><td>0.37</td><td>0.63</td></tr><tr><td>Any mucinous differentiation</td><td>0.63</td><td>0.69</td><td>0.34</td><td>0.65</td></tr><tr><td>Poor differentiation</td><td>0.27</td><td>0.89</td><td>0.13</td><td>0.88</td></tr><tr><td>Family history of cancers (B4.B5)</td><td>0.64</td><td>0.92</td><td>0.13</td><td>0.87</td></tr><tr><td>Revised Bethesda guidelines</td><td>0.78</td><td>0.77</td><td>0.3</td><td>0.7</td></tr><tr><td>Revised Bethesda guidelines (modified B1, age limit &lt;45 y)</td><td>0.78</td><td>0.89</td><td>0.19</td><td>0.80</td></tr></table>
<table><tr><td>Variable</td><td>Sensitivity</td><td>Specificity</td><td>Positive predictive value</td><td>Negative predictive value</td></tr><tr><td>B3 criterion</td><td>0.44</td><td>0.91</td><td>0.13</td><td>0.87</td></tr><tr><td>MSI histology</td><td>0.79</td><td>0.85</td><td>0.20</td><td>0.80</td></tr><tr><td>MsPath score*</td><td>0.86</td><td>0.85</td><td>0.18</td><td>0.82</td></tr><tr><td>Tumor infiltrating lymphocytes</td><td>0.52</td><td>0.65</td><td>0.37</td><td>0.63</td></tr><tr><td>Any mucinous differentiation</td><td>0.63</td><td>0.69</td><td>0.34</td><td>0.65</td></tr><tr><td>Poor differentiation</td><td>0.27</td><td>0.89</td><td>0.13</td><td>0.88</td></tr><tr><td>Family history of cancers (B4.B5)</td><td>0.64</td><td>0.92</td><td>0.13</td><td>0.87</td></tr><tr><td>Revised Bethesda guidelines</td><td>0.78</td><td>0.77</td><td>0.3</td><td>0.7</td></tr></table>
<table><tr><td>Variable</td><td>Sensitivity</td><td>Specificity</td><td>Positive predictive value</td><td>Negative predictive value</td></tr><tr><td>Revised Bethesda guidelines (modified B1, age limit <45 y)</td><td>0.78</td><td>0.89</td><td>0.19</td><td>0.80</td></tr></table>
1e2cf5ad2fd4fd011fe73dd3ebc05b74b3c104a98c61c0e3aef8d02fbc3f2e9b.png
complex
<table><tr><td rowspan="5"> </td><td colspan="4">Men</td><td colspan="4">Women</td></tr><tr><td colspan="3">Household income</td><td rowspan="3"><i>P</i></td><td colspan="3">Household income</td><td rowspan="3"><i>P</i></td></tr><tr><td>Low</td><td>Middle</td><td>High</td><td>Low</td><td>Middle</td><td>High</td></tr><tr><td colspan="9">Total energy intake, kcal/day</td></tr><tr><td> Model 1</td><td>1,968 (39)</td><td>2,061 (21)</td><td>1,958 (36)</td><td>0.012</td><td>1,701 (27)</td><td>1,710 (16)</td><td>1,757 (27)</td><td>0.259</td></tr><tr><td> Model 2</td><td>1,969 (39)</td><td>2,062 (21)</td><td>1,953 (36)</td><td>0.009</td><td>1,703 (27)</td><td>1,710 (16)</td><td>1,754 (27)</td><td>0.336</td></tr><tr><td> Model 3</td><td>1,978 (40)</td><td>2,061 (21)</td><td>1,948 (37)</td><td>0.010</td><td>1,711 (28)</td><td>1,710 (16)</td><td>1,748 (28)</td><td>0.474</td></tr><tr><td colspan="9">Protein, % energy</td></tr><tr><td> Model 1</td><td>15.3 (0.2)</td><td>15.3 (0.1)</td><td>15.5 (0.2)</td><td>0.718</td><td>15.1 (0.2)</td><td>15.5 (0.1)</td><td>15.8 (0.2)</td><td>0.037</td></tr><tr><td> Model 2</td><td>15.3 (0.2)</td><td>15.3 (0.1)</td><td>15.5 (0.2)</td><td>0.748</td><td>15.0 (0.2)</td><td>15.5 (0.1)</td><td>15.9 (0.2)</td><td>0.016</td></tr><tr><td> Model 3</td><td>15.5 (0.3)</td><td>15.3 (0.1)</td><td>15.4 (0.2)</td><td>0.742</td><td>15.2 (0.2)</td><td>15.5 (0.1)</td><td>15.7 (0.2)</td><td>0.378</td></tr><tr><td colspan="9">Fat, % energy</td></tr><tr><td> Model 1</td><td>22.3 (0.5)</td><td>25.0 (0.3)</td><td>26.1 (0.5)</td><td>&lt;0.001</td><td>24.6 (0.4)</td><td>26.2 (0.3)</td><td>27.6 (0.4)</td><td>&lt;0.001</td></tr><tr><td> Model 2</td><td>23.2 (0.5)</td><td>25.0 (0.3)</td><td>25.9 (0.5)</td><td>0.001</td><td>24.7 (0.4)</td><td>26.2 (0.3)</td><td>27.5 (0.4)</td><td>&lt;0.001</td></tr><tr><td> Model 3</td><td>23.2 (0.5)</td><td>25.0 (0.3)</td><td>25.9 (0.5)</td><td>0.001</td><td>24.9 (0.5)</td><td>26.1 (0.3)</td><td>27.3 (0.5)</td><td>0.003</td></tr><tr><td colspan="9">Carbohydrate, % energy</td></tr><tr><td> Model 1</td><td>61.5 (0.6)</td><td>59.5 (0.3)</td><td>58.2 (0.6)</td><td>0.001</td><td>60.2 (0.5)</td><td>58.2 (0.3)</td><td>56.5 (0.5)</td><td>&lt;0.001</td></tr><tr><td> Model 2</td><td>61.3 (0.6)</td><td>59.5 (0.3)</td><td>58.4 (0.6)</td><td>0.003</td><td>60.1 (0.5)</td><td>58.2 (0.3)</td><td>56.5 (0.5)</td><td>&lt;0.001</td></tr><tr><td> Model 3</td><td>61.1 (0.6)</td><td>59.5 (0.3)</td><td>58.6 (0.6)</td><td>0.015</td><td>59.7 (0.5)</td><td>58.3 (0.3)</td><td>56.8 (0.5)</td><td>0.002</td></tr></table>
<table><tr><td rowspan="5"></td><td colspan="4">Men</td><td colspan="4">Women</td></tr><tr><td colspan="3">Household income</td><td rowspan="3">P</td><td colspan="3">Household income</td><td rowspan="3">P</td></tr><tr><td>Low</td><td>Middle</td><td>High</td><td>Low</td><td>Middle</td><td>High</td></tr><tr><td rowspan="2" colspan="3"></td><td rowspan="2" colspan="3"></td></tr><tr><td></td><td></td></tr><tr><td colspan="9">Total energy intake, kcal/day</td></tr><tr><td>Model 1</td><td>1,968 (39)</td><td>2,061 (21)</td><td>1,958 (36)</td><td>0.012</td><td>1,701 (27)</td><td>1,710 (16)</td><td>1,757 (27)</td><td>0.259</td></tr><tr><td>Model 2</td><td>1,969 (39)</td><td>2,062 (21)</td><td>1,953 (36)</td><td>0.009</td><td>1,703 (27)</td><td>1,710 (16)</td><td>1,754 (27)</td><td>0.336</td></tr><tr><td>Model 3</td><td>1,978 (40)</td><td>2,061 (21)</td><td>1,948 (37)</td><td>0.010</td><td>1,711 (28)</td><td>1,710 (16)</td><td>1,748 (28)</td><td>0.474</td></tr><tr><td colspan="9">Protein, % energy</td></tr><tr><td>Model 1</td><td>15.3 (0.2)</td><td>15.3 (0.1)</td><td>15.5 (0.2)</td><td>0.718</td><td>15.1 (0.2)</td><td>15.5 (0.1)</td><td>15.8 (0.2)</td><td>0.037</td></tr><tr><td>Model 2</td><td>15.3 (0.2)</td><td>15.3 (0.1)</td><td>15.5 (0.2)</td><td>0.748</td><td>15.0 (0.2)</td><td>15.5 (0.1)</td><td>15.9 (0.2)</td><td>0.016</td></tr><tr><td>Model 3</td><td>15.5 (0.3)</td><td>15.3 (0.1)</td><td>15.4 (0.2)</td><td>0.742</td><td>15.2 (0.2)</td><td>15.5 (0.1)</td><td>15.7 (0.2)</td><td>0.378</td></tr></table>
<table><tr><td rowspan="5"></td><td colspan="4">Men</td><td colspan="4">Women</td></tr><tr><td colspan="3">Household income</td><td rowspan="3">P</td><td colspan="3">Household income</td><td rowspan="3">P</td></tr><tr><td>Low</td><td>Middle</td><td>High</td><td>Low</td><td>Middle</td><td>High</td></tr><tr><td rowspan="2" colspan="3"></td><td rowspan="2" colspan="3"></td></tr><tr><td></td><td></td></tr><tr><td colspan="9">Fat, % energy</td></tr><tr><td>Model 1</td><td>22.3 (0.5)</td><td>25.0 (0.3)</td><td>26.1 (0.5)</td><td><0.001</td><td>24.6 (0.4)</td><td>26.2 (0.3)</td><td>27.6 (0.4)</td><td><0.001</td></tr><tr><td>Model 2</td><td>23.2 (0.5)</td><td>25.0 (0.3)</td><td>25.9 (0.5)</td><td>0.001</td><td>24.7 (0.4)</td><td>26.2 (0.3)</td><td>27.5 (0.4)</td><td><0.001</td></tr><tr><td>Model 3</td><td>23.2 (0.5)</td><td>25.0 (0.3)</td><td>25.9 (0.5)</td><td>0.001</td><td>24.9 (0.5)</td><td>26.1 (0.3)</td><td>27.3 (0.5)</td><td>0.003</td></tr><tr><td colspan="9">Carbohydrate, % energy</td></tr><tr><td>Model 1</td><td>61.5 (0.6)</td><td>59.5 (0.3)</td><td>58.2 (0.6)</td><td>0.001</td><td>60.2 (0.5)</td><td>58.2 (0.3)</td><td>56.5 (0.5)</td><td><0.001</td></tr><tr><td>Model 2</td><td>61.3 (0.6)</td><td>59.5 (0.3)</td><td>58.4 (0.6)</td><td>0.003</td><td>60.1 (0.5)</td><td>58.2 (0.3)</td><td>56.5 (0.5)</td><td><0.001</td></tr><tr><td>Model 3</td><td>61.1 (0.6)</td><td>59.5 (0.3)</td><td>58.6 (0.6)</td><td>0.015</td><td>59.7 (0.5)</td><td>58.3 (0.3)</td><td>56.8 (0.5)</td><td>0.002</td></tr></table>
31613bf1e0177154617a71e732264e9e0a6a435f3c9e182eabf9aecf36a6d3b0.png
complex
<table><tr><td>Words</td><td>Mean</td><td>SD</td></tr><tr><td colspan="3">Arousal</td></tr><tr><td>Negative</td><td>5.24</td><td>1.49</td></tr><tr><td>Positive</td><td>4.68</td><td>1.47</td></tr><tr><td>Neutral</td><td>2.77</td><td>1.32</td></tr><tr><td colspan="3">Valence</td></tr><tr><td>Negative</td><td>2.58</td><td>0.79</td></tr><tr><td>Positive</td><td>7.62</td><td>0.55</td></tr><tr><td>Neutral</td><td>5.00</td><td>0.34</td></tr></table>
<table><tr><td>Words</td><td>Mean</td><td>SD</td></tr><tr><td colspan="3">Arousal</td></tr><tr><td>Negative</td><td>5.24</td><td>1.49</td></tr><tr><td>Positive</td><td>4.68</td><td>1.47</td></tr><tr><td>Neutral</td><td>2.77</td><td>1.32</td></tr><tr><td colspan="3">Valence</td></tr><tr><td>Negative</td><td>2.58</td><td>0.79</td></tr></table>
<table><tr><td>Words</td><td>Mean</td><td>SD</td></tr><tr><td>Positive</td><td>7.62</td><td>0.55</td></tr><tr><td>Neutral</td><td>5.00</td><td>0.34</td></tr></table>
916b953f011baa1a6505dd0c6318c56ecf5fbc7dbd8be2021b8ddb4bdb4ade7d.png
complex
<table><tr><td>Characteristics</td><td>Survivors (<i>n</i> = 64)</td><td>Non-survivors (<i>n</i> = 46)</td><td><i>P</i></td></tr><tr><td colspan="4">At ICU admission</td></tr><tr><td> Age (years old)</td><td>60 [45&#8211;69]</td><td>63 [57&#8211;73]</td><td>0.03</td></tr><tr><td> Male sex</td><td>49 (76.6)</td><td>29 (63)</td><td>0.12</td></tr><tr><td> Weight (kg)</td><td>70 [60&#8211;80]</td><td>70 [58&#8211;79]</td><td>0.84</td></tr><tr><td> Body mass index (kg/m<sup>2</sup>)</td><td>24.6 [20.7&#8211;27.8]</td><td>24.4 [20.7&#8211;28]</td><td>0.58</td></tr><tr><td> APACHE II</td><td>21 [17&#8211;25]</td><td>26 [22&#8211;29]</td><td>0.0007</td></tr><tr><td> Simplified Acute Physiology Score 2</td><td>52 [41&#8211;60]</td><td>57 [45&#8211;73]</td><td>0.05</td></tr><tr><td> History of congestive heart failure</td><td>6 (9.4)</td><td>6 (13)</td><td>0.54</td></tr><tr><td> Liver cirrhosis</td><td>0</td><td>4 (8.7)</td><td>0.03</td></tr><tr><td> Chronic obstructive pulmonary disease</td><td>15 (23.4)</td><td>11 (23.9)</td><td>0.96</td></tr><tr><td> Chronic kidney disease requiring dialysis</td><td>4 (6.3)</td><td>5 (10.9)</td><td>0.38</td></tr><tr><td> Cancer (&lt;3 months) </td><td>11 (17.2)</td><td>5 (10.9)</td><td>0.35</td></tr><tr><td> Diabetes mellitus</td><td>15 (23.4)</td><td>24 (52.2)</td><td>0.002</td></tr><tr><td> Immunodepression</td><td>16 (25)</td><td>8 (17.4)</td><td>0.34</td></tr><tr><td colspan="4">At the day of aminoglycoside administration</td></tr><tr><td> Day since admission</td><td>1 [0&#8211;5]</td><td>2 [0&#8211;7]</td><td>0.32</td></tr><tr><td> Emergent surgery</td><td>17 (26.6)</td><td>8 (17.4)</td><td>0.26</td></tr><tr><td> Sequential Organ Failure Assessment score</td><td>9 [7&#8211;10]</td><td>10 [9&#8211;13]</td><td>0.004</td></tr><tr><td> Weight (kg)</td><td>70 [60&#8211;81]</td><td>70.5 [60&#8211;80]</td><td>0.92</td></tr><tr><td> Weight gain since ICU admission (kg)</td><td>0 [0&#8211;2]</td><td>0 [0&#8211;3]</td><td>0.62</td></tr><tr><td> Extracorporeal membrane oxygenation</td><td>7 (10.9)</td><td>8 (17.4)</td><td>0.33</td></tr><tr><td> Catecholamines</td><td>49 (76.6)</td><td>40 (87)</td><td>0.17</td></tr><tr><td> Norepinephrine (&#956;g/kg/min)</td><td>0.26 [0.04&#8211;0.61]</td><td>0.83 [0.41&#8211;1.65]</td><td>0.0002</td></tr><tr><td> PaO<sub>2</sub>/FiO<sub>2</sub> ratio</td><td>200 [140&#8211;280]</td><td>147 [103&#8211;259]</td><td>0.06</td></tr><tr><td> Renal replacement therapy</td><td>19 (29.7)</td><td>21 (45.7)</td><td>0.09</td></tr><tr><td> Glomerular filtration rate (mL/min)</td><td>53.5 [29.7&#8211;90.4]</td><td>29.8 [0&#8211;65.9]</td><td>0.008</td></tr><tr><td> Lactate level (mmol/L)</td><td>1.7 [1.2&#8211;3.1]</td><td>3.2 [1.4&#8211;7]</td><td>0.01</td></tr><tr><td> Platelet count (G/L)</td><td>205 [105&#8211;339]</td><td>201 [86&#8211;270]</td><td>0.47</td></tr><tr><td> Hematocrit level (%)</td><td>29.2 [26&#8211;31.3]</td><td>29.7 [26&#8211;32.4]</td><td>0.54</td></tr><tr><td> Leucocyte count (G/L)</td><td>15.6 [9.4&#8211;22.3]</td><td>13.4 [7.8&#8211;18.7]</td><td>0.22</td></tr><tr><td> Glasgow Coma Scale score</td><td>15 [14, 15]</td><td>15 [12&#8211;15]</td><td>0.23</td></tr><tr><td> Bilirubin level (mg/dL)</td><td>12 [8&#8211;17]</td><td>145 [9&#8211;26]</td><td>0.22</td></tr><tr><td> Prothrombin time (%)</td><td>72 [57&#8211;81]</td><td>60 [47&#8211;75]</td><td>0.01</td></tr><tr><td> Proteinemia (g/L)</td><td>58 [49&#8211;64]</td><td>52 [46&#8211;62]</td><td>0.1</td></tr><tr><td> Amikacin <i>C</i><sub>max</sub> between 60 and 80 mg/L</td><td>34 (53.1)</td><td>13 (28.3)</td><td>0.009</td></tr></table>
<table><tr><td>Characteristics</td><td>Survivors (n = 64)</td><td>Non-survivors (n = 46)</td><td>P</td></tr><tr><td colspan="4">At ICU admission</td></tr><tr><td>Age (years old)</td><td>60 [45–69]</td><td>63 [57–73]</td><td>0.03</td></tr><tr><td>Male sex</td><td>49 (76.6)</td><td>29 (63)</td><td>0.12</td></tr><tr><td>Weight (kg)</td><td>70 [60–80]</td><td>70 [58–79]</td><td>0.84</td></tr><tr><td>Body mass index (kg/m2)</td><td>24.6 [20.7–27.8]</td><td>24.4 [20.7–28]</td><td>0.58</td></tr><tr><td>APACHE II</td><td>21 [17–25]</td><td>26 [22–29]</td><td>0.0007</td></tr><tr><td>Simplified Acute Physiology Score 2</td><td>52 [41–60]</td><td>57 [45–73]</td><td>0.05</td></tr><tr><td>History of congestive heart failure</td><td>6 (9.4)</td><td>6 (13)</td><td>0.54</td></tr><tr><td>Liver cirrhosis</td><td>0</td><td>4 (8.7)</td><td>0.03</td></tr><tr><td>Chronic obstructive pulmonary disease</td><td>15 (23.4)</td><td>11 (23.9)</td><td>0.96</td></tr><tr><td>Chronic kidney disease requiring dialysis</td><td>4 (6.3)</td><td>5 (10.9)</td><td>0.38</td></tr><tr><td>Cancer (<3 months)</td><td>11 (17.2)</td><td>5 (10.9)</td><td>0.35</td></tr><tr><td>Diabetes mellitus</td><td>15 (23.4)</td><td>24 (52.2)</td><td>0.002</td></tr><tr><td>Immunodepression</td><td>16 (25)</td><td>8 (17.4)</td><td>0.34</td></tr><tr><td colspan="4">At the day of aminoglycoside administration</td></tr><tr><td>Day since admission</td><td>1 [0–5]</td><td>2 [0–7]</td><td>0.32</td></tr><tr><td>Emergent surgery</td><td>17 (26.6)</td><td>8 (17.4)</td><td>0.26</td></tr><tr><td>Sequential Organ Failure Assessment score</td><td>9 [7–10]</td><td>10 [9–13]</td><td>0.004</td></tr><tr><td>Weight (kg)</td><td>70 [60–81]</td><td>70.5 [60–80]</td><td>0.92</td></tr></table>
<table><tr><td>Characteristics</td><td>Survivors (n = 64)</td><td>Non-survivors (n = 46)</td><td>P</td></tr><tr><td>Weight gain since ICU admission (kg)</td><td>0 [0–2]</td><td>0 [0–3]</td><td>0.62</td></tr><tr><td>Extracorporeal membrane oxygenation</td><td>7 (10.9)</td><td>8 (17.4)</td><td>0.33</td></tr><tr><td>Catecholamines</td><td>49 (76.6)</td><td>40 (87)</td><td>0.17</td></tr><tr><td>Norepinephrine (μg/kg/min)</td><td>0.26 [0.04–0.61]</td><td>0.83 [0.41–1.65]</td><td>0.0002</td></tr><tr><td>PaO2/FiO2 ratio</td><td>200 [140–280]</td><td>147 [103–259]</td><td>0.06</td></tr><tr><td>Renal replacement therapy</td><td>19 (29.7)</td><td>21 (45.7)</td><td>0.09</td></tr><tr><td>Glomerular filtration rate (mL/min)</td><td>53.5 [29.7–90.4]</td><td>29.8 [0–65.9]</td><td>0.008</td></tr><tr><td>Lactate level (mmol/L)</td><td>1.7 [1.2–3.1]</td><td>3.2 [1.4–7]</td><td>0.01</td></tr><tr><td>Platelet count (G/L)</td><td>205 [105–339]</td><td>201 [86–270]</td><td>0.47</td></tr><tr><td>Hematocrit level (%)</td><td>29.2 [26–31.3]</td><td>29.7 [26–32.4]</td><td>0.54</td></tr><tr><td>Leucocyte count (G/L)</td><td>15.6 [9.4–22.3]</td><td>13.4 [7.8–18.7]</td><td>0.22</td></tr><tr><td>Glasgow Coma Scale score</td><td>15 [14, 15]</td><td>15 [12–15]</td><td>0.23</td></tr><tr><td>Bilirubin level (mg/dL)</td><td>12 [8–17]</td><td>145 [9–26]</td><td>0.22</td></tr><tr><td>Prothrombin time (%)</td><td>72 [57–81]</td><td>60 [47–75]</td><td>0.01</td></tr><tr><td>Proteinemia (g/L)</td><td>58 [49–64]</td><td>52 [46–62]</td><td>0.1</td></tr><tr><td>Amikacin Cmax between 60 and 80 mg/L</td><td>34 (53.1)</td><td>13 (28.3)</td><td>0.009</td></tr></table>
d3f803d92a1351dde0d469096c7178cb95f8a5bcec9d7b132783ecf959630b4c.png
complex
<table><tr><td><i>Dependent variables</i></td><td>Adjusted R<sup>2</sup></td><td>Independent variables (partial regression coefficient) <sup>b</sup></td></tr><tr><td rowspan="2"><i>Tension</i></td><td rowspan="2">0.214***</td><td>SOC (&#8722;0.408***)</td></tr><tr><td>Job demand (quantity) (&#8722;0.193**)</td></tr><tr><td rowspan="2"><i>Fatigue</i></td><td rowspan="2">0.306**</td><td>SOC (&#8722;0.390***)</td></tr><tr><td>Job demand (quantity) (&#8722;0.357***)</td></tr><tr><td rowspan="3"><i>Anxiety</i></td><td rowspan="3">0.313***</td><td>SOC (&#8722;0.352***)</td></tr><tr><td>Job demand (quality) (&#8722;0.349***)</td></tr><tr><td>Low support from supervisor (0.187*)</td></tr><tr><td rowspan="4"><i>Depression</i></td><td rowspan="4">0.335***</td><td>SOC (&#8722;0.411***)</td></tr><tr><td>Low support from supervisor (0.197**)</td></tr><tr><td>Married (&#8722;0.195**)</td></tr><tr><td>Job demand (quantity) (&#8722;0.158*)</td></tr><tr><td><i>Subjective symptoms</i></td><td>0.092***</td><td>SOC (&#8722;0.314***)</td></tr><tr><td rowspan="3"><i>Vigor</i></td><td rowspan="3">0.395***</td><td>SOC (0.275**)</td></tr><tr><td>Low job aptitude (&#8722;0.206**)</td></tr><tr><td>Low support from supervisor (&#8722;0.254***)</td></tr><tr><td rowspan="3"><i>Self-rated health</i></td><td rowspan="3">0.018*</td><td>Physical job load (&#8722;0.183**)</td></tr><tr><td>Work duration (0.182*)</td></tr><tr><td>Low support from colleagues (&#8722;0.157*)</td></tr></table>
<table><tr><td>Dependent variables</td><td>Adjusted R2</td><td>Independent variables (partial regression coefficient) b</td></tr><tr><td rowspan="2">Tension</td><td rowspan="2">0.214***</td><td>SOC (−0.408***)</td></tr><tr><td>Job demand (quantity) (−0.193**)</td></tr><tr><td rowspan="2">Fatigue</td><td rowspan="2">0.306**</td><td>SOC (−0.390***)</td></tr><tr><td>Job demand (quantity) (−0.357***)</td></tr><tr><td rowspan="3">Anxiety</td><td rowspan="3">0.313***</td><td>SOC (−0.352***)</td></tr><tr><td>Job demand (quality) (−0.349***)</td></tr><tr><td>Low support from supervisor (0.187*)</td></tr><tr><td rowspan="4">Depression</td><td rowspan="4">0.335***</td><td>SOC (−0.411***)</td></tr><tr><td>Low support from supervisor (0.197**)</td></tr><tr><td>Married (−0.195**)</td></tr><tr><td>Job demand (quantity) (−0.158*)</td></tr></table>
<table><tr><td>Dependent variables</td><td>Adjusted R2</td><td>Independent variables (partial regression coefficient) b</td></tr><tr><td>Subjective symptoms</td><td>0.092***</td><td>SOC (−0.314***)</td></tr><tr><td rowspan="3">Vigor</td><td rowspan="3">0.395***</td><td>SOC (0.275**)</td></tr><tr><td>Low job aptitude (−0.206**)</td></tr><tr><td>Low support from supervisor (−0.254***)</td></tr><tr><td rowspan="3">Self-rated health</td><td rowspan="3">0.018*</td><td>Physical job load (−0.183**)</td></tr><tr><td>Work duration (0.182*)</td></tr><tr><td>Low support from colleagues (−0.157*)</td></tr></table>
60f2afb11a051dd9afd4b954950d75cdc41487417ddfc8e07859b0531ba6e727.png
complex
<table><tr><td colspan="2">Signs and symptoms of Flammer syndrome</td><td>Patient 1</td><td>Patient 2</td><td>Patient 3</td><td>Patient 4</td></tr><tr><td>1</td><td>Do you suffer from cold hands or feet even in summer time?</td><td>+</td><td>+</td><td>+</td><td>+</td></tr><tr><td>2</td><td>Do you have a low blood pressure?</td><td>+</td><td>&#8211;</td><td>+</td><td>&#8211;</td></tr><tr><td>3</td><td>Are you less thirsty than others?</td><td>+</td><td>+</td><td>&#8211;</td><td>&#8211;</td></tr><tr><td>4</td><td>If you have to take medications, do you have the feeling that you react strongly to them?</td><td>+</td><td>Not known</td><td>Not known</td><td>+</td></tr><tr><td>5</td><td>Do you suffer from migraines?</td><td>+</td><td>Not reported</td><td>&#8211;</td><td>Not reported</td></tr><tr><td>6</td><td>Do you suffer from tinnitus (ringing in your ears)?</td><td>Not reported</td><td>+</td><td>+</td><td>+</td></tr><tr><td>7</td><td>Do you often feel cold when you are not moving for sometime?</td><td>+</td><td>+</td><td>+</td><td>+</td></tr><tr><td>8</td><td>Do you need a relatively long time to fall asleep, especially when you are cold?</td><td>+</td><td>+</td><td>+</td><td>+</td></tr><tr><td>9</td><td>Do you identify smells better than others?</td><td>+</td><td>Not reported</td><td>+</td><td>Not known</td></tr><tr><td>10</td><td>Have you noticed reversible skin blotches (white or red) when you were excited or angry?</td><td>+</td><td>+</td><td>+</td><td>+</td></tr></table>
<table><tr><td colspan="2">Signs and symptoms of Flammer syndrome</td><td>Patient 1</td><td>Patient 2</td><td>Patient 3</td><td>Patient 4</td></tr><tr><td>1</td><td>Do you suffer from cold hands or feet even in summer time?</td><td>+</td><td>+</td><td>+</td><td>+</td></tr><tr><td>2</td><td>Do you have a low blood pressure?</td><td>+</td><td>–</td><td>+</td><td>–</td></tr><tr><td>3</td><td>Are you less thirsty than others?</td><td>+</td><td>+</td><td>–</td><td>–</td></tr><tr><td>4</td><td>If you have to take medications, do you have the feeling that you react strongly to them?</td><td>+</td><td>Not known</td><td>Not known</td><td>+</td></tr></table>
<table><tr><td colspan="2">Signs and symptoms of Flammer syndrome</td><td>Patient 1</td><td>Patient 2</td><td>Patient 3</td><td>Patient 4</td></tr><tr><td>5</td><td>Do you suffer from migraines?</td><td>+</td><td>Not reported</td><td>–</td><td>Not reported</td></tr><tr><td>6</td><td>Do you suffer from tinnitus (ringing in your ears)?</td><td>Not reported</td><td>+</td><td>+</td><td>+</td></tr><tr><td>7</td><td>Do you often feel cold when you are not moving for sometime?</td><td>+</td><td>+</td><td>+</td><td>+</td></tr><tr><td>8</td><td>Do you need a relatively long time to fall asleep, especially when you are cold?</td><td>+</td><td>+</td><td>+</td><td>+</td></tr><tr><td>9</td><td>Do you identify smells better than others?</td><td>+</td><td>Not reported</td><td>+</td><td>Not known</td></tr><tr><td>10</td><td>Have you noticed reversible skin blotches (white or red) when you were excited or angry?</td><td>+</td><td>+</td><td>+</td><td>+</td></tr></table>
16be8c61095e525e4b08f0d3f94bccf9206b3786d182656f81a06d5f38b4e180.png
complex
<table><tr><td>Group</td><td>Type</td><td>Model</td><td>AUC</td><td>Specificity</td><td>Sensitivity</td></tr><tr><td rowspan="3">Early</td><td>Parenclitic</td><td>-7.44 (Alpha-centrality)</td><td>0.624</td><td>1</td><td>0.189 &#177; 0.124</td></tr><tr><td></td><td>-0.16 (Pill use)</td><td></td><td></td><td></td></tr><tr><td>RDLG</td><td>-2.09 (GPC1)</td><td>0.663</td><td>1</td><td>0.163 &#177; 0.087</td></tr><tr><td rowspan="2">Late</td><td>Parenclitic</td><td>0.07 (Connections to MUC16)</td><td>0.904</td><td>1</td><td>0.803 &#177; 0.077</td></tr><tr><td>RDLG</td><td>2.14 (MUC16)</td><td>0.904</td><td>1</td><td>0.767 &#177; 0.082</td></tr></table>
<table><tr><td>Group</td><td>Type</td><td>Model</td><td>AUC</td><td>Specificity</td><td>Sensitivity</td></tr><tr><td rowspan="3">Early</td><td>Parenclitic</td><td>-7.44 (Alpha-centrality)</td><td>0.624</td><td>1</td><td>0.189 ± 0.124</td></tr><tr><td></td><td>-0.16 (Pill use)</td><td></td><td></td><td></td></tr><tr><td>RDLG</td><td>-2.09 (GPC1)</td><td>0.663</td><td>1</td><td>0.163 ± 0.087</td></tr></table>
<table><tr><td rowspan="2">Late</td><td>Parenclitic</td><td>0.07 (Connections to MUC16)</td><td>0.904</td><td>1</td><td>0.803 ± 0.077</td></tr><tr><td>RDLG</td><td>2.14 (MUC16)</td><td>0.904</td><td>1</td><td>0.767 ± 0.082</td></tr></table>
836a512021c0b2b93f6bb3a79667e15853c79e3fcf8ea699adf959c325cc510e.png
simple
<table><tr><td> </td><td>N = 90</td></tr><tr><td>None</td><td> </td></tr><tr><td>No contraceptive use (includes abstinence, withdrawal, celibacy)</td><td>49</td></tr><tr><td>Pregnant or trying to get pregnant</td><td>5</td></tr><tr><td>Permanent methods</td><td> </td></tr><tr><td>Tubal ligation, partner vasectomy</td><td>6</td></tr><tr><td>Long-acting methods</td><td> </td></tr><tr><td>Implanon</td><td>6</td></tr><tr><td>Depo</td><td>5</td></tr><tr><td>IUD</td><td>1</td></tr><tr><td>Reversible methods</td><td> </td></tr><tr><td>The pill</td><td>4</td></tr><tr><td>Condoms</td><td>17*</td></tr><tr><td>Diaphragm</td><td>0</td></tr></table>
<table><tr><td></td></tr><tr><td>None</td></tr><tr><td>No contraceptive use (includes abstinence, withdrawal, celibacy)</td></tr><tr><td>Pregnant or trying to get pregnant</td></tr><tr><td>Permanent methods</td></tr><tr><td>Tubal ligation, partner vasectomy</td></tr><tr><td>Long-acting methods</td></tr><tr><td>Implanon</td></tr><tr><td>Depo</td></tr><tr><td>IUD</td></tr><tr><td>Reversible methods</td></tr><tr><td>The pill</td></tr><tr><td>Condoms</td></tr><tr><td>Diaphragm</td></tr></table>
<table><tr><td>N = 90</td></tr><tr><td></td></tr><tr><td>49</td></tr><tr><td>5</td></tr><tr><td></td></tr><tr><td>6</td></tr><tr><td></td></tr><tr><td>6</td></tr><tr><td>5</td></tr><tr><td>1</td></tr><tr><td></td></tr><tr><td>4</td></tr><tr><td>17*</td></tr><tr><td>0</td></tr></table>
75cf02081633bbc7649ad26d18c447785cc3b950d09c340aa970bb209b4268dc.png
complex
<table><tr><td rowspan="2">Brain region</td><td rowspan="2">Group</td><td colspan="5">Content (ng/mg protein)</td></tr><tr><td>DA</td><td>DOPAC</td><td>HVA</td><td>NA</td><td>5-HT </td></tr><tr><td rowspan="2">Striatum</td><td>6-OHDA</td><td>1364 &#177; 337.2</td><td>1266 &#177; 223</td><td>777.2 &#177; 107.8</td><td>131 &#177; 19.5</td><td>227.9 &#177; 15.7</td></tr><tr><td>6-OHDA + SR</td><td>2099 &#177; 759.9</td><td>1190 &#177; 61.8</td><td>828.4 &#177; 74.4</td><td>125.7 &#177; 6.5</td><td>248.1 &#177; 32.2</td></tr><tr><td rowspan="2">Prefrontal cortex</td><td>6-OHDA</td><td>16.8 &#177; 4.1</td><td>20.2 &#177; 11.7</td><td>35.1 &#177; 7.5</td><td>104.9 &#177; 29</td><td>198.4 &#177; 107.1</td></tr><tr><td>6-OHDA + SR</td><td>17.1 &#177; 4.7</td><td>12.3 &#177; 5.4</td><td>42.5 &#177; 5.3</td><td>208.7 &#177; 16.6*</td><td>467.3 &#177; 24.9*</td></tr><tr><td rowspan="2">Hippocampus</td><td>6-OHDA</td><td>23.4 &#177; 7.8</td><td>17.6 &#177; 2.8</td><td>53.9 &#177; 14.2</td><td>195.9 &#177; 44.4</td><td>116.4 &#177; 59.6</td></tr><tr><td>6-OHDA + SR</td><td>28 &#177; 4.4</td><td>20.3 &#177; 2.5</td><td>32.8 &#177; 8.5</td><td>297.5 &#177; 28.2</td><td>165.6 &#177; 41.6</td></tr></table>
<table><tr><td rowspan="2">Brain</td><td rowspan="2">Grou</td><td colspan="5">Content (ng/mg protein)</td></tr><tr><td></td><td>D</td><td></td><td></td><td>5-HT</td></tr></table>
<table><tr><td> region</td><td>p</td><td>DA</td><td>OPAC</td><td>HVA</td><td>NA</td><td></td></tr><tr><td rowspan="2">Striatum</td><td>6-OHDA</td><td>1364 ± 337.2</td><td>1266 ± 223</td><td>777.2 ± 107.8</td><td>131 ± 19.5</td><td>227.9 ± 15.7</td></tr><tr><td>6-OHDA + SR</td><td>2099 ± 759.9</td><td>1190 ± 61.8</td><td>828.4 ± 74.4</td><td>125.7 ± 6.5</td><td>248.1 ± 32.2</td></tr><tr><td rowspan="2">Prefrontal cortex</td><td>6-OHDA</td><td>16.8 ± 4.1</td><td>20.2 ± 11.7</td><td>35.1 ± 7.5</td><td>104.9 ± 29</td><td>198.4 ± 107.1</td></tr><tr><td>6-OHDA + SR</td><td>17.1 ± 4.7</td><td>12.3 ± 5.4</td><td>42.5 ± 5.3</td><td>208.7 ± 16.6*</td><td>467.3 ± 24.9*</td></tr><tr><td rowspan="2">Hippocampus</td><td>6-OHDA</td><td>23.4 ± 7.8</td><td>17.6 ± 2.8</td><td>53.9 ± 14.2</td><td>195.9 ± 44.4</td><td>116.4 ± 59.6</td></tr><tr><td>6-OHDA + SR</td><td>28 ± 4.4</td><td>20.3 ± 2.5</td><td>32.8 ± 8.5</td><td>297.5 ± 28.2</td><td>165.6 ± 41.6</td></tr></table>
172c796ac1b773861fa1dfa5ce395539db69ed7a6de7fc96e704933ea0605530.png
complex
<table><tr><td></td><td></td><td colspan="3">Bone densities (HU)</td></tr><tr><td></td><td>Number of implant sites</td><td>Inside (SD)</td><td>Outside (SD)</td><td>Combination of inside and outside (SD) </td></tr><tr><td>Jaw section</td><td></td><td></td><td></td><td></td></tr><tr><td> Maxilla</td><td>31</td><td>523.8 (267.5)</td><td>558.1 (202.2)<sup>a</sup></td><td>540.9 (201.9)<sup>b</sup></td></tr><tr><td> Mandible</td><td>73</td><td>567.6 (228.7)</td><td>712.4 (222.3)<sup>a</sup></td><td>640.0 (214.9)<sup>b</sup></td></tr><tr><td>Region</td><td></td><td></td><td></td><td></td></tr><tr><td>Anterior</td><td>15</td><td>659.6 (270.1)</td><td>730.4 (279.1)</td><td>695.0 (206.0)</td></tr><tr><td>Posterior</td><td>89</td><td>536.9 (232.1)</td><td>655.6 (216.9)</td><td>596.2 (214.3)</td></tr><tr><td>Procedure</td><td></td><td></td><td></td><td></td></tr><tr><td>1-stage</td><td>66</td><td>571.5 (233.8)</td><td>690.1 (235.6)</td><td>630.8 (223.1)</td></tr><tr><td>2-stage</td><td>38</td><td>525.1 (251.9)</td><td>625.2 (207.6)</td><td>575.2 (198.1)</td></tr></table>
<table><tr><td></td><td></td><td>Bone densities (HU)</td></tr><tr><td></td><td>Number of implant sites</td><td>Inside (SD)</td></tr><tr><td>Jaw section</td><td></td><td></td></tr><tr><td>Maxilla</td><td>31</td><td>523.8 (267.5)</td></tr><tr><td>Mandible</td><td>73</td><td>567.6 (228.7)</td></tr><tr><td>Region</td><td></td><td></td></tr><tr><td>Anterior</td><td>15</td><td>659.6 (270.1)</td></tr><tr><td>Posterior</td><td>89</td><td>536.9 (232.1)</td></tr><tr><td>Procedure</td><td></td><td></td></tr><tr><td>1-stage</td><td>66</td><td>571.5 (233.8)</td></tr><tr><td>2-stage</td><td>38</td><td>525.1 (251.9)</td></tr></table>
<table><tr><td colspan="2">Bone densities (HU)</td></tr><tr><td>Outside (SD)</td><td>Combination of inside and outside (SD)</td></tr><tr><td></td><td></td></tr><tr><td>558.1 (202.2)a</td><td>540.9 (201.9)b</td></tr><tr><td>712.4 (222.3)a</td><td>640.0 (214.9)b</td></tr><tr><td></td><td></td></tr><tr><td>730.4 (279.1)</td><td>695.0 (206.0)</td></tr><tr><td>655.6 (216.9)</td><td>596.2 (214.3)</td></tr><tr><td></td><td></td></tr><tr><td>690.1 (235.6)</td><td>630.8 (223.1)</td></tr><tr><td>625.2 (207.6)</td><td>575.2 (198.1)</td></tr></table>
c6b41ea714040ea6e6985d9b8b8a04cccc77124e1fc1a88b7ca1bf6997cc1f4c.png
complex
<table><tr><td></td><td>Total patients</td><td>NLR &lt;3</td><td>NLR &#8805;3</td><td>p-value</td></tr><tr><td></td><td>(n =632)</td><td>(n =376)</td><td>(n =256)</td><td></td></tr><tr><td>Age, years</td><td>55.18 (13 &#8211; 91)</td><td>53.48 (17 &#8211; 91)</td><td>57.68 (13 &#8211; 89)</td><td>0.001</td></tr><tr><td>Sex</td><td></td><td></td><td></td><td>0.001</td></tr><tr><td>Men</td><td>297 (47.0)</td><td>156 (41.5)</td><td>141 (55.1)</td><td rowspan="2"></td></tr><tr><td>Women</td><td>335 (53.0)</td><td>220 (58.5)</td><td>115 (44.9)</td></tr><tr><td>Body-mass index</td><td>24.51 &#177; 3.81</td><td>24.59 &#177; 3.86</td><td>24.35 &#177; 3.72</td><td>0.445</td></tr><tr><td>Previous abdominal surgery (%)</td><td>140 (22.2)</td><td>89 (23.7)</td><td>51 (19.9)</td><td>0.284</td></tr><tr><td>Severity of cholecystitis</td><td></td><td></td><td></td><td>&lt; 0.001</td></tr><tr><td>Simple cholecystitis</td><td>503 (79.6)</td><td>342 (91.0)</td><td>161 (62.9)</td><td rowspan="2"></td></tr><tr><td>Severe cholecystitis*</td><td>129 (20.4)</td><td>34 (9.0)</td><td>95 (37.1)</td></tr><tr><td>Content in the gallbladder</td><td></td><td></td><td></td><td>0.122</td></tr><tr><td>No</td><td>121 (19.1)</td><td>64 (17.0)</td><td>57 (22.3)</td><td rowspan="2"></td></tr><tr><td>Stone(s)</td><td>511 (80.9)</td><td>312 (83.0)</td><td>199 (77.7)</td></tr><tr><td>Serum leukocyte count</td><td>7700</td><td>6200</td><td>11300</td><td>&lt; 0.001</td></tr><tr><td></td><td>(1500 &#8211; 39300)</td><td>(2700 &#8211; 16500)</td><td>(1500 &#8211; 39300)</td><td></td></tr><tr><td>Presence of symptom</td><td></td><td></td><td></td><td>0.038</td></tr><tr><td>Abdominal pain</td><td>586 (92.7)</td><td>342 (91.0)</td><td>244 (95.3)</td><td rowspan="4"></td></tr><tr><td>Indigestion (discomfort)</td><td>25 (4.0)</td><td>19 (5.1)</td><td>6 (2.3)</td></tr><tr><td>Fever/Chill</td><td>7 (1.1)</td><td>3 (0.8)</td><td>4 (1.6)</td></tr><tr><td>Others</td><td>14 (2.2)</td><td>12 (3.2)</td><td>2 (0.8)</td></tr><tr><td>Admission route</td><td></td><td></td><td></td><td>&lt; 0.001</td></tr><tr><td>ED</td><td>280 (44.3)</td><td>120 (31.9)</td><td>160 (62.5)</td><td rowspan="2"></td></tr><tr><td>Outpatient clinic</td><td>352 (55.7)</td><td>256 (68.1)</td><td>96 (37.5)</td></tr><tr><td>Time to incision</td><td></td><td></td><td></td><td>0.497</td></tr><tr><td>Mean &#177; SD</td><td>35.1 &#177; 27.0</td><td>34.5 &#177; 26.9</td><td>36.0 &#177; 27.2</td><td rowspan="2"></td></tr><tr><td>Median (range)</td><td>23.0 (1 &#8211; 120)</td><td>22.0 (1 &#8211; 120)</td><td>24.0 (2 &#8211; 119)</td></tr></table>
<table><tr><td></td><td>Total patients</td><td>NLR <3</td></tr><tr><td></td><td>(n =632)</td><td>(n =376)</td></tr><tr><td>Age, years</td><td>55.18 (13 – 91)</td><td>53.48 (17 – 91)</td></tr><tr><td>Sex</td><td></td><td></td></tr><tr><td>Men</td><td>297 (47.0)</td><td>156 (41.5)</td></tr><tr><td>Women</td><td>335 (53.0)</td><td>220 (58.5)</td></tr><tr><td>Body-mass index</td><td>24.51 ± 3.81</td><td>24.59 ± 3.86</td></tr><tr><td>Previous abdominal surgery (%)</td><td>140 (22.2)</td><td>89 (23.7)</td></tr><tr><td>Severity of cholecystitis</td><td></td><td></td></tr><tr><td>Simple cholecystitis</td><td>503 (79.6)</td><td>342 (91.0)</td></tr><tr><td>Severe cholecystitis*</td><td>129 (20.4)</td><td>34 (9.0)</td></tr><tr><td>Content in the gallbladder</td><td></td><td></td></tr><tr><td>No</td><td>121 (19.1)</td><td>64 (17.0)</td></tr><tr><td>Stone(s)</td><td>511 (80.9)</td><td>312 (83.0)</td></tr><tr><td>Serum leukocyte count</td><td>7700</td><td>6200</td></tr><tr><td></td><td>(1500 – 39300)</td><td>(2700 – 16500)</td></tr><tr><td>Presence of symptom</td><td></td><td></td></tr><tr><td>Abdominal pain</td><td>586 (92.7)</td><td>342 (91.0)</td></tr><tr><td>Indigestion (discomfort)</td><td>25 (4.0)</td><td>19 (5.1)</td></tr><tr><td>Fever/Chill</td><td>7 (1.1)</td><td>3 (0.8)</td></tr><tr><td>Others</td><td>14 (2.2)</td><td>12 (3.2)</td></tr><tr><td>Admission route</td><td></td><td></td></tr><tr><td>ED</td><td>280 (44.3)</td><td>120 (31.9)</td></tr><tr><td>Outpatient clinic</td><td>352 (55.7)</td><td>256 (68.1)</td></tr><tr><td>Time to incision</td><td></td><td></td></tr><tr><td>Mean ± SD</td><td>35.1 ± 27.0</td><td>34.5 ± 26.9</td></tr><tr><td>Median (range)</td><td>23.0 (1 – 120)</td><td>22.0 (1 – 120)</td></tr></table>
<table><tr><td>NLR ≥3</td><td>p-value</td></tr><tr><td>(n =256)</td><td></td></tr><tr><td>57.68 (13 – 89)</td><td>0.001</td></tr><tr><td></td><td>0.001</td></tr><tr><td>141 (55.1)</td><td rowspan="2"></td></tr><tr><td>115 (44.9)</td></tr><tr><td>24.35 ± 3.72</td><td>0.445</td></tr><tr><td>51 (19.9)</td><td>0.284</td></tr><tr><td></td><td>< 0.001</td></tr><tr><td>161 (62.9)</td><td rowspan="2"></td></tr><tr><td>95 (37.1)</td></tr><tr><td></td><td>0.122</td></tr><tr><td>57 (22.3)</td><td rowspan="2"></td></tr><tr><td>199 (77.7)</td></tr><tr><td>11300</td><td>< 0.001</td></tr><tr><td>(1500 – 39300)</td><td></td></tr><tr><td></td><td>0.038</td></tr><tr><td>244 (95.3)</td><td rowspan="4"></td></tr><tr><td>6 (2.3)</td></tr><tr><td>4 (1.6)</td></tr><tr><td>2 (0.8)</td></tr><tr><td></td><td>< 0.001</td></tr><tr><td>160 (62.5)</td><td rowspan="2"></td></tr><tr><td>96 (37.5)</td></tr><tr><td></td><td>0.497</td></tr><tr><td>36.0 ± 27.2</td><td rowspan="2"></td></tr><tr><td>24.0 (2 – 119)</td></tr></table>
706078c1903fb3f986d894880c484caaca9a0fe9adadbbe571d7931743dc7a0a.png
simple
<table><tr><td>Layer</td><td>Type</td><td>Input</td><td>Kernel</td><td>Output</td></tr><tr><td>1</td><td>Convolution</td><td>28 &#215; 28 &#215; 1</td><td>5 &#215; 5</td><td>24 &#215; 24 &#215; 32</td></tr><tr><td>2</td><td>Max pooling</td><td>24 &#215; 24 &#215; 32</td><td>2 &#215; 2</td><td>12 &#215; 12 &#215; 64</td></tr><tr><td>3</td><td>Convolution</td><td>12 &#215; 12 &#215; 64</td><td>5 &#215; 5</td><td>8 &#215; 8 &#215; 64</td></tr><tr><td>4</td><td>Max pooling</td><td>8 &#215; 8 &#215; 64</td><td>2 &#215; 2</td><td>4 &#215; 4 &#215; 64</td></tr><tr><td>5</td><td>Fully connected</td><td>4 &#215; 4 &#215; 64</td><td>4 &#215; 4</td><td>512 &#215; 1</td></tr><tr><td>6</td><td>Fully connected</td><td>512 &#215; 1</td><td>1 &#215; 1</td><td>2 &#215; 1</td></tr><tr><td>7</td><td>Softmax</td><td>2 &#215; 1</td><td>N/A</td><td>Result</td></tr></table>
<table><tr><td>Layer</td><td>Type</td><td>Input</td><td>Kernel</td><td>Output</td></tr></table>
<table><tr><td>1</td><td>Convolution</td><td>28 × 28 × 1</td><td>5 × 5</td><td>24 × 24 × 32</td></tr><tr><td>2</td><td>Max pooling</td><td>24 × 24 × 32</td><td>2 × 2</td><td>12 × 12 × 64</td></tr><tr><td>3</td><td>Convolution</td><td>12 × 12 × 64</td><td>5 × 5</td><td>8 × 8 × 64</td></tr><tr><td>4</td><td>Max pooling</td><td>8 × 8 × 64</td><td>2 × 2</td><td>4 × 4 × 64</td></tr><tr><td>5</td><td>Fully connected</td><td>4 × 4 × 64</td><td>4 × 4</td><td>512 × 1</td></tr><tr><td>6</td><td>Fully connected</td><td>512 × 1</td><td>1 × 1</td><td>2 × 1</td></tr><tr><td>7</td><td>Softmax</td><td>2 × 1</td><td>N/A</td><td>Result</td></tr></table>
0d76571c2c0ed8877a27dae24f29659d4e2799a30b8b03449e1e8d0e6a300333.png
simple
<table><tr><td>Group</td><td>Age</td><td>Optical density</td><td>Standard deviation</td></tr><tr><td>A</td><td>&lt;10</td><td>0.7840</td><td>0.0044</td></tr><tr><td>B</td><td>11-20</td><td>0.6974</td><td>0.0435</td></tr><tr><td>C</td><td>21-30</td><td>0.7028</td><td>0.0300</td></tr><tr><td>D</td><td>31-40</td><td>0.7730</td><td>0.0375</td></tr><tr><td>E</td><td>41-50</td><td>0.7270</td><td>0.0347</td></tr><tr><td>F</td><td>51-60</td><td>0.8272</td><td>0.0379</td></tr><tr><td>G</td><td>61-70</td><td>0.7953</td><td>0.0253</td></tr><tr><td>H</td><td>71-80</td><td>0.8435</td><td>0.0264</td></tr><tr><td>I</td><td>80&gt;</td><td>0.8166</td><td>0.0409</td></tr></table>
<table><tr><td>Group</td><td>Age</td><td>Optical density</td><td>Standard deviation</td></tr><tr><td>A</td><td><10</td><td>0.7840</td><td>0.0044</td></tr><tr><td>B</td><td>11-20</td><td>0.6974</td><td>0.0435</td></tr><tr><td>C</td><td>21-30</td><td>0.7028</td><td>0.0300</td></tr><tr><td>D</td><td>31-40</td><td>0.7730</td><td>0.0375</td></tr><tr><td>E</td><td>41-50</td><td>0.7270</td><td>0.0347</td></tr></table>
<table><tr><td>F</td><td>51-60</td><td>0.8272</td><td>0.0379</td></tr><tr><td>G</td><td>61-70</td><td>0.7953</td><td>0.0253</td></tr><tr><td>H</td><td>71-80</td><td>0.8435</td><td>0.0264</td></tr><tr><td>I</td><td>80></td><td>0.8166</td><td>0.0409</td></tr></table>
196980b397241b5f2cd2f117b5b5defca0b5dd52853cb9028408421701bbf93f.png
simple
<table><tr><td>Home visits to recipients of programme ITNs</td><td>N = 13</td><td>95% Conf. Int.</td></tr><tr><td># of household ITNs found matched self-report</td><td>13/13 (100%)</td><td>-</td></tr><tr><td>Total # of ITNs found in all visited households</td><td>32</td><td>-</td></tr><tr><td>Mean ITNs per household</td><td>32/13 = 2.5</td><td>-</td></tr><tr><td> ITNs in working order and mounted</td><td>28/32 (88%)</td><td>(72 &#8211; 95)</td></tr><tr><td> ITNs torn and not mounted</td><td>1/32 (3%)</td><td>-</td></tr><tr><td> ITNs torn and still mounted</td><td>3/32 (9%)</td><td>-</td></tr><tr><td>Households in which none of ITNs were mounted</td><td>3/13 (33%)</td><td>(8 &#8211; 50)</td></tr></table>
<table><tr><td>Home visits to recipients of programme ITNs</td><td>N = 13</td><td>95% Conf. Int.</td></tr><tr><td># of </td><td>13</td><td>-</td></tr></table>
<table><tr><td>Home visits to recipients of programme ITNs</td><td>N = 13</td><td>95% Conf. Int.</td></tr><tr><td>household ITNs found matched self-report</td><td>/13 (100%)</td><td></td></tr><tr><td>Total # of ITNs found in all visited households</td><td>32</td><td>-</td></tr><tr><td>Mean ITNs per household</td><td>32/13 = 2.5</td><td>-</td></tr><tr><td>ITNs in working order and mounted</td><td>28/32 (88%)</td><td>(72 – 95)</td></tr><tr><td>ITNs torn and not mounted</td><td>1/32 (3%)</td><td>-</td></tr><tr><td>ITNs torn and still mounted</td><td>3/32 (9%)</td><td>-</td></tr><tr><td>Households in which none of ITNs were mounted</td><td>3/13 (33%)</td><td>(8 – 50)</td></tr></table>
be4d96754dc01293931365dd9b07fe0aa51d8aa4357d8ed3a8268261c9287af5.png
simple
<table><tr><td>Variables</td><td>Food-Secure Household (<i>n</i> = 5413)</td><td>Food-Insecure Household without Hunger (<i>n</i> = 381)</td><td>Food-Insecure Household with Hunger (<i>n</i> = 68)</td><td><i>p</i>-Value</td></tr><tr><td>Energy <sup>1</sup></td><td>28.1 &#177; 0.8</td><td>31.7 &#177; 3.1</td><td>43.7 &#177; 6.1</td><td>0.029</td></tr><tr><td>Protein <sup>2</sup></td><td>9.60 &#177; 0.5</td><td>8.70 &#177; 1.8</td><td>8.40 &#177; 4.5</td><td>0.868</td></tr><tr><td>Protein <sup>3</sup></td><td>18.3 &#177; 0.7</td><td>23.1 &#177; 2.7</td><td>34.7 &#177; 6.6</td><td>0.003</td></tr><tr><td>Fiber <sup>3</sup></td><td>97.6 &#177; 0.3</td><td>98.3 &#177; 0.7</td><td>98.9 &#177; 1.1</td><td>0.567</td></tr><tr><td>Calcium <sup>3</sup></td><td>66.1 &#177; 0.8</td><td>70.7 &#177; 2.9</td><td>86.4 &#177; 3.4</td><td>0.002</td></tr><tr><td>Phosphorous <sup>3</sup></td><td>7.80 &#177; 0.4</td><td>13.1 &#177; 2.1</td><td>24.5 &#177; 6.6</td><td>&lt;0.001</td></tr><tr><td>Iron <sup>3</sup></td><td>19.6 &#177; 0.7</td><td>24.9 &#177; 2.7</td><td>29.9 &#177; 6.1</td><td>0.018</td></tr><tr><td>Sodium <sup>4</sup></td><td>6.5 &#177; 0.4</td><td>8.60 &#177; 1.8</td><td>13.0 &#177; 4.2</td><td>0.072</td></tr><tr><td>Potassium <sup>4</sup></td><td>66.0 &#177; 0.8</td><td>67.9 &#177; 2.9</td><td>84.7 &#177; 4.6</td><td>0.017</td></tr><tr><td>Vitamin A <sup>3</sup></td><td>39.6 &#177; 0.8</td><td>46.7 &#177; 3.2</td><td>55.9 &#177; 7.1</td><td>0.006</td></tr><tr><td>Vitamin B1 <sup>3</sup></td><td>17.1 &#177; 0.7</td><td>25.4 &#177; 3.2</td><td>23.8 &#177; 5.5</td><td>0.003</td></tr><tr><td>Vitamin B2 <sup>3</sup></td><td>41.3 &#177; 0.8</td><td>45.7 &#177; 3.3</td><td>60.2 &#177; 7.3</td><td>0.023</td></tr><tr><td>Niacin <sup>3</sup></td><td>24.5 &#177; 0.7</td><td>37.2 &#177; 3.4</td><td>46.1 &#177; 7.7</td><td>&lt;0.001</td></tr><tr><td>Vitamin C <sup>3</sup></td><td>47.5 &#177; 1.0</td><td>59.8 &#177; 2.9</td><td>68.6 &#177; 6.4</td><td>&lt;0.001</td></tr></table>
<table><tr><td>Variables</td><td>Food-Secure Household (n = 5413)</td><td>Food-Insecure Household without Hunger (n = 381)</td><td>Food-Insecure Household with Hunger (n = 68)</td><td>p-Value</td></tr><tr><td>Energy 1</td><td>28.1 ± 0.8</td><td>31.7 ± 3.1</td><td>43.7 ± 6.1</td><td>0.029</td></tr><tr><td>Protein 2</td><td>9.60 ± 0.5</td><td>8.70 ± 1.8</td><td>8.40 ± 4.5</td><td>0.868</td></tr><tr><td>Protein 3</td><td>18.3 ± 0.7</td><td>23.1 ± 2.7</td><td>34.7 ± 6.6</td><td>0.003</td></tr><tr><td>Fiber 3</td><td>97.6 ± 0.3</td><td>98.3 ± 0.7</td><td>98.9 ± 1.1</td><td>0.567</td></tr><tr><td>Calcium 3</td><td>66.1 ± 0.8</td><td>70.7 ± 2.9</td><td>86.4 ± 3.4</td><td>0.002</td></tr><tr><td>Phosphorous 3</td><td>7.80 ± 0.4</td><td>13.1 ± 2.1</td><td>24.5 ± 6.6</td><td><0.001</td></tr><tr><td>Iron 3</td><td>19.6 ± 0.7</td><td>24.9 ± 2.7</td><td>29.9 ± 6.1</td><td>0.018</td></tr><tr><td>Sodium 4</td><td>6.5 ± 0.4</td><td>8.60 ± 1.8</td><td>13.0 ± 4.2</td><td>0.072</td></tr><tr><td>Potassium 4</td><td>66.0 ± 0.8</td><td>67.9 ± 2.9</td><td>84.7 ± 4.6</td><td>0.017</td></tr></table>
<table><tr><td>Variables</td><td>Food-Secure Household (n = 5413)</td><td>Food-Insecure Household without Hunger (n = 381)</td><td>Food-Insecure Household with Hunger (n = 68)</td><td>p-Value</td></tr><tr><td>Vitamin A 3</td><td>39.6 ± 0.8</td><td>46.7 ± 3.2</td><td>55.9 ± 7.1</td><td>0.006</td></tr><tr><td>Vitamin B1 3</td><td>17.1 ± 0.7</td><td>25.4 ± 3.2</td><td>23.8 ± 5.5</td><td>0.003</td></tr><tr><td>Vitamin B2 3</td><td>41.3 ± 0.8</td><td>45.7 ± 3.3</td><td>60.2 ± 7.3</td><td>0.023</td></tr><tr><td>Niacin 3</td><td>24.5 ± 0.7</td><td>37.2 ± 3.4</td><td>46.1 ± 7.7</td><td><0.001</td></tr><tr><td>Vitamin C 3</td><td>47.5 ± 1.0</td><td>59.8 ± 2.9</td><td>68.6 ± 6.4</td><td><0.001</td></tr></table>
2bb25fa0c65446a71fdddbaa5a36928f5bf318ace21ce7696b56517c34f58ab6.png
simple
<table><tr><td>Step</td><td>covariate removed</td><td>no. of variables</td><td>log-l</td><td>AIC</td><td>cvlog-l</td></tr><tr><td>0</td><td>all (null model)</td><td>0</td><td>-675.7</td><td>-675.7</td><td>-846.8</td></tr><tr><td>1</td><td>none (final model)</td><td>6</td><td>-502.1</td><td>-509.1</td><td>-743.1</td></tr><tr><td>2</td><td>&#946;<sub>2</sub>M</td><td>5</td><td>-504.6</td><td>-510.6</td><td>-738.8</td></tr><tr><td>3</td><td>&#946;<sub>2</sub>M and sex</td><td>4</td><td>-618.9</td><td>-623.9</td><td>-738.8</td></tr></table>
<table><tr><td>Step</td><td>covariate removed</td><td>no. of variables</td><td>log-l</td><td>AIC</td><td>cvlog-l</td></tr><tr><td>0</td><td>all (null model)</td><td>0</td><td>-675.7</td><td>-675.7</td><td>-846.8</td></tr><tr><td>1</td><td>none (final model)</td><td>6</td><td>-502.1</td><td>-509.1</td><td>-743.1</td></tr></table>
<table><tr><td>2</td><td>β2M</td><td>5</td><td>-504.6</td><td>-510.6</td><td>-738.8</td></tr><tr><td>3</td><td>β2M and sex</td><td>4</td><td>-618.9</td><td>-623.9</td><td>-738.8</td></tr></table>
c13baef647c125ab47d4b16c70460e13cbf7a8c62dc22501271f080a2a003679.png
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<table><tr><td>Centrality measures (<i>M</i><sub>i</sub>)</td><td><i>|PeC </i>&#8745; <i>M</i><sub>i</sub>|</td><td>|<i>M<sub>i </sub></i>- <i>PeC</i>|</td><td>Non-essential proteins in {<i>M<sub>i </sub></i>- <i>PeC</i>}</td><td>Percentage of non-essential proteins in {<i>M<sub>i </sub></i>- <i>PeC</i>} with low PeC</td></tr><tr><td>Degree Centrality (DC)</td><td>18</td><td>82</td><td>44</td><td>54.5%</td></tr><tr><td>Betweenness Centrality (BC)</td><td>16</td><td>84</td><td>47</td><td>51.1%</td></tr><tr><td>Closeness Centrality (CC)</td><td>16</td><td>84</td><td>51</td><td>56.9%</td></tr><tr><td>Subgraph Centrality(SC)</td><td>11</td><td>89</td><td>59</td><td>64.4%</td></tr><tr><td>Eigenvector Centrality(EC)</td><td>11</td><td>89</td><td>59</td><td>64.4%</td></tr><tr><td>Information Centrality(IC)</td><td>17</td><td>83</td><td>47</td><td>55.3%</td></tr><tr><td>Bottle Neck (BN)</td><td>16</td><td>84</td><td>53</td><td>45.3%</td></tr><tr><td>Density of Maximum Neighborhood Component (DMNC)</td><td>12</td><td>88</td><td>42</td><td>42.9%</td></tr><tr><td>Local Average Connectivity-based method (LAC)</td><td>34</td><td>66</td><td>37</td><td>59.5%</td></tr><tr><td>Sum of ECC (SoECC)</td><td>37</td><td>63</td><td>31</td><td>54.8%</td></tr><tr><td>Range-Limited Centrality (RL)</td><td>17</td><td>83</td><td>42</td><td>54.8%</td></tr><tr><td>L-index (LI)</td><td>13</td><td>87</td><td>55</td><td>58.2%</td></tr><tr><td>Leader Rank(LR)</td><td>16</td><td>84</td><td>46</td><td>52.2%</td></tr><tr><td>Normalized <i>&#945;</i>-Centrality (NC)</td><td>11</td><td>89</td><td>59</td><td>64.4%</td></tr><tr><td>Moduland-Centrality(MC)</td><td>11</td><td>89</td><td>57</td><td>66.7%</td></tr></table>
<table><tr><td>Centrality measures (Mi)</td><td>|PeC ∩ Mi|</td><td>|Mi - PeC|</td><td>Non-essential proteins in {Mi - PeC}</td><td>Percentage of non-essential proteins in {Mi - PeC} with low PeC</td></tr><tr><td>Degree Centrality (DC)</td><td>18</td><td>82</td><td>44</td><td>54.5%</td></tr><tr><td>Betweenness Centrality (BC)</td><td>16</td><td>84</td><td>47</td><td>51.1%</td></tr><tr><td>Closeness Centrality (CC)</td><td>16</td><td>84</td><td>51</td><td>56.9%</td></tr><tr><td>Subgraph Centrality(SC)</td><td>11</td><td>89</td><td>59</td><td>64.4%</td></tr><tr><td>Eigenvector Centrality(EC)</td><td>11</td><td>89</td><td>59</td><td>64.4%</td></tr><tr><td>Information Centrality(IC)</td><td>17</td><td>83</td><td>47</td><td>55.3%</td></tr><tr><td>Bottle Neck (BN)</td><td>16</td><td>84</td><td>53</td><td>45.3%</td></tr><tr><td>Density of Maximum Neighborhood Component (DMNC)</td><td>12</td><td>88</td><td>42</td><td>42.9%</td></tr><tr><td>Local Average Connectivity-based method (LAC)</td><td>34</td><td>66</td><td>37</td><td>59.5%</td></tr><tr><td>Sum of ECC (SoECC)</td><td>37</td><td>63</td><td>31</td><td>54.8%</td></tr></table>
<table><tr><td>Centrality measures (Mi)</td><td>|PeC ∩ Mi|</td><td>|Mi - PeC|</td><td>Non-essential proteins in {Mi - PeC}</td><td>Percentage of non-essential proteins in {Mi - PeC} with low PeC</td></tr><tr><td>Range-Limited Centrality (RL)</td><td>17</td><td>83</td><td>42</td><td>54.8%</td></tr><tr><td>L-index (LI)</td><td>13</td><td>87</td><td>55</td><td>58.2%</td></tr><tr><td>Leader Rank(LR)</td><td>16</td><td>84</td><td>46</td><td>52.2%</td></tr><tr><td>Normalized α-Centrality (NC)</td><td>11</td><td>89</td><td>59</td><td>64.4%</td></tr><tr><td>Moduland-Centrality(MC)</td><td>11</td><td>89</td><td>57</td><td>66.7%</td></tr></table>
918a74b09c7c40d48d10233bf10ed6b6592c6bfc8e776ab0651a4995aa527624.png
simple
<table><tr><td>Target of deletion</td><td>Animal model</td><td>Results of immunization</td><td>Reference</td></tr><tr><td>Biopterin transporter, LdBT1<sup>&#8722;/&#8722;</sup></td><td>Balb/C</td><td>Protective immunity, antigen-specific IFN-&#947; secretion</td><td>Papadopoulou et al. (53)</td></tr><tr><td>Centrin 1, LdCen<sup>&#8722;/&#8722;</sup></td><td>Balb/C mice, hamsters, dogs</td><td>Protective immunity against <i>L. donovani</i> and <i>L. braziliensis</i> challenge. Increased IFN&#947;, IL-2, and TNF producing cells and IFN&#947;/IL-10 ratio, presence of multifunctional cells</td><td>Selvapandiyan et al. (48), Fiuza et al. (58)</td></tr><tr><td>Silent information regulatory two single allele deletion, LiSIR2&#177;</td><td>Balb/C</td><td>Protective immunity, increased antigen-specific IFN&#947;/IL-10 ratio</td><td>Silvestre et al. (55)</td></tr><tr><td>Cytochrome <i>c</i> oxidase complex component p27, Ldp27<sup>&#8722;/&#8722;</sup></td><td>Balb/C</td><td>12-Week survival in host, protective immunity against <i>L. donovani</i>, <i>L. braziliensis</i>, and <i>L. major</i> challenge. Increased IFN&#947;, IL-2, and TNF producing cells and IFN&#947;/IL-10 ratio</td><td>Dey et al. (49)</td></tr><tr><td>Heat shock protein 70, LiHsp70<sup>&#8722;/&#8722;</sup></td><td>Balb/C</td><td>Cross protection against <i>L. major</i>, high IgG2a relative to IgG1</td><td>Carrion et al. (56)</td></tr></table>
<table><tr><td>Target of deletion</td><td>Animal model</td><td>Results of immunization</td><td>Reference</td></tr></table>
<table><tr><td>Biopterin transporter, LdBT1−/−</td><td>Balb/C</td><td>Protective immunity, antigen-specific IFN-γ secretion</td><td>Papadopoulou et al. (53)</td></tr><tr><td>Centrin 1, LdCen−/−</td><td>Balb/C mice, hamsters, dogs</td><td>Protective immunity against L. donovani and L. braziliensis challenge. Increased IFNγ, IL-2, and TNF producing cells and IFNγ/IL-10 ratio, presence of multifunctional cells</td><td>Selvapandiyan et al. (48), Fiuza et al. (58)</td></tr><tr><td>Silent information regulatory two single allele deletion, LiSIR2±</td><td>Balb/C</td><td>Protective immunity, increased antigen-specific IFNγ/IL-10 ratio</td><td>Silvestre et al. (55)</td></tr><tr><td>Cytochrome c oxidase complex component p27, Ldp27−/−</td><td>Balb/C</td><td>12-Week survival in host, protective immunity against L. donovani, L. braziliensis, and L. major challenge. Increased IFNγ, IL-2, and TNF producing cells and IFNγ/IL-10 ratio</td><td>Dey et al. (49)</td></tr><tr><td>Heat shock protein 70, LiHsp70−/−</td><td>Balb/C</td><td>Cross protection against L. major, high IgG2a relative to IgG1</td><td>Carrion et al. (56)</td></tr></table>
4b8276331c0cd3b530f1e652e34c1865a5ec5cf57a1df3d76b4f53b58780a537.png
complex
<table><tr><td rowspan="2">Metric variables</td><td rowspan="2">Virginity status</td><td colspan="2">Gender</td></tr><tr><td>Females<sup>a</sup></td><td>Males<sup>b</sup></td></tr><tr><td><i>Age at death (wk)</i></td><td><i>Virgin</i></td><td>99.2 &#177; 2.4<sup>c</sup> (7, 141)<sup>d</sup></td><td>85.2 &#177; 3.4<sup>e</sup> (1, 133)</td></tr><tr><td><i>Age at death (wk)</i></td><td><i>Mated</i></td><td>88.3 &#177; 5.2 (35, 138)</td><td>104.0 &#177; 3.8 (61, 149)</td></tr><tr><td><i>Total number of litters produced by a dam/stud</i></td><td></td><td>8.9 &#177; 0.7 (2, 16)</td><td>10.5 &#177; 1.1 (1, 19)</td></tr><tr><td><i>Total number of pups at birth produced by a dam/stud</i></td><td></td><td>56.8 &#177; 5.2 (4, 92)</td><td>97.2 &#177; 10.7<sup>f</sup> (1, 169)</td></tr><tr><td><i>Total number of pups at weaning produced by a dam/stud</i></td><td></td><td>52.4 &#177; 5.0 (3, 88)</td><td>92.2 &#177; 10.1<sup>f</sup> (1, 162)</td></tr><tr><td><i>Age at last litter (wk)</i></td><td></td><td>51.9 &#177; 2.8 (31, 80)</td><td>92.2 &#177; 4.3<sup>g</sup> (54, 130)</td></tr><tr><td><i>Time interval between mating &amp; last litter (wk)</i></td><td></td><td>34.1 &#177; 2.8 (6, 55)</td><td>40.2 &#177; 4.3 (2, 78)</td></tr><tr><td><i>Time interval between litters (wk)</i></td><td></td><td>3.8 &#177; 0.1 (3, 5.4)</td><td>3.7 &#177; 0.2 (2, 5.6)</td></tr><tr><td><i>Time interval between last litter &amp; death (wk)</i></td><td></td><td>29.2 &#177; 4.7 (0, 88)</td><td>11.8 &#177; 4.2<sup>h</sup> (0, 94)</td></tr></table>
<table><tr><td rowspan="2">Metric variables</td><td rowspan="2">Virginity status</td><td colspan="2">Gender</td></tr><tr><td>Femalesa</td><td>Malesb</td></tr><tr><td>Age at death (wk)</td><td>Virgin</td><td>99.2 ± 2.4c (7, 141)d</td><td>85.2 ± 3.4e (1, 133)</td></tr><tr><td>Age at death (wk)</td><td>Mated</td><td>88.3 ± 5.2 (35, 138)</td><td>104.0 ± 3.8 (61, 149)</td></tr><tr><td>Total number of litters produced by a dam/stud</td><td></td><td>8.9 ± 0.7 (2, 16)</td><td>10.5 ± 1.1 (1, 19)</td></tr><tr><td>Total number of pups at birth produced by a dam/stud</td><td></td><td>56.8 ± 5.2 (4, 92)</td><td>97.2 ± 10.7f (1, 169)</td></tr><tr><td>Total number of pups at weaning produced by a dam/stud</td><td></td><td>52.4 ± 5.0 (3, 88)</td><td>92.2 ± 10.1f (1, 162)</td></tr><tr><td>Age at last litter (wk)</td><td></td><td>51.9 ± 2.8 (31, 80)</td><td>92.2 ± 4.3g (54, 130)</td></tr></table>
<table><tr><td>Time interval between mating & last litter (wk)</td><td></td><td>34.1 ± 2.8 (6, 55)</td><td>40.2 ± 4.3 (2, 78)</td></tr><tr><td>Time interval between litters (wk)</td><td></td><td>3.8 ± 0.1 (3, 5.4)</td><td>3.7 ± 0.2 (2, 5.6)</td></tr><tr><td>Time interval between last litter & death (wk)</td><td></td><td>29.2 ± 4.7 (0, 88)</td><td>11.8 ± 4.2h (0, 94)</td></tr></table>
bcc71ea287a579cdc967f35daf5e5baa47be1255f00008a4cb3320af8c0c3794.png
complex
<table><tr><td rowspan="2"></td><td colspan="2">Survival to hospital discharge</td><td colspan="2">Good neurological recovery</td></tr><tr><td>OR (95% CI)</td><td><i>p</i> Value</td><td>OR (95% CI)</td><td><i>p</i> Value</td></tr><tr><td>Male sex</td><td>1.536 (1.121&#8211;2.104)</td><td>0.008</td><td></td><td></td></tr><tr><td>Age, years</td><td>0.990 (0.982&#8211;0.999)</td><td>0.032</td><td>0.961 (0.946&#8211;0.977)</td><td>&lt; 0.001</td></tr><tr><td>Call-to-hospital arrival time</td><td>0.979 (0.965&#8211;0.993)</td><td>0.003</td><td>0.950 (0.921&#8211;0.980)</td><td>0.001</td></tr><tr><td>ACLS time</td><td>0.952 (0.938&#8211;0.966)</td><td>&lt; 0.001</td><td>0.956 (0.929&#8211;0.982)</td><td>0.001</td></tr><tr><td>Witnessed arrest</td><td></td><td></td><td>2.814 (1.406&#8211;5.632)</td><td>0.003</td></tr><tr><td>Shockable rhythm in ED</td><td>1.829 (1.194&#8211;2.802)</td><td>0.006</td><td>8.111 (4.632&#8211;14.203)</td><td>&lt; 0.001</td></tr><tr><td>TTM</td><td>5.860 (4.332&#8211;7.928)</td><td>&lt; 0.0001</td><td>7.546 (4.406&#8211;12.924)</td><td>&lt; 0.001</td></tr><tr><td>E-PCI</td><td></td><td></td><td>4.442 (1.940&#8211;10.170)</td><td>&lt; 0.001</td></tr><tr><td>E-CAG</td><td>2.316 (1.345&#8211;3.988)</td><td>0.002</td><td></td><td></td></tr><tr><td>pH</td><td>6.287 (2.601&#8211;15.197)</td><td>&lt; 0.001</td><td>15.395 (3.439&#8211;68.911)</td><td>&lt; 0.001</td></tr><tr><td>Potassium</td><td>0.888 (0.821&#8211;0.962)</td><td>0.003</td><td></td><td></td></tr></table>
<table><tr><td rowspan="2"></td><td colspan="2">Survival to hospital discharge</td><td colspan="2">Good neurological recovery</td></tr><tr><td>OR (95% CI)</td><td>p Value</td><td>OR (95% CI)</td><td>p Value</td></tr><tr><td>Male sex</td><td>1.536 (1.121–2.104)</td><td>0.008</td><td></td><td></td></tr><tr><td>Age, years</td><td>0.990 (0.982–0.999)</td><td>0.032</td><td>0.961 (0.946–0.977)</td><td>< 0.001</td></tr><tr><td>Call-to-hospital arrival time</td><td>0.979 (0.965–0.993)</td><td>0.003</td><td>0.950 (0.921–0.980)</td><td>0.001</td></tr></table>
<table><tr><td>ACLS time</td><td>0.952 (0.938–0.966)</td><td>< 0.001</td><td>0.956 (0.929–0.982)</td><td>0.001</td></tr><tr><td>Witnessed arrest</td><td></td><td></td><td>2.814 (1.406–5.632)</td><td>0.003</td></tr><tr><td>Shockable rhythm in ED</td><td>1.829 (1.194–2.802)</td><td>0.006</td><td>8.111 (4.632–14.203)</td><td>< 0.001</td></tr><tr><td>TTM</td><td>5.860 (4.332–7.928)</td><td>< 0.0001</td><td>7.546 (4.406–12.924)</td><td>< 0.001</td></tr><tr><td>E-PCI</td><td></td><td></td><td>4.442 (1.940–10.170)</td><td>< 0.001</td></tr><tr><td>E-CAG</td><td>2.316 (1.345–3.988)</td><td>0.002</td><td></td><td></td></tr><tr><td>pH</td><td>6.287 (2.601–15.197)</td><td>< 0.001</td><td>15.395 (3.439–68.911)</td><td>< 0.001</td></tr><tr><td>Potassium</td><td>0.888 (0.821–0.962)</td><td>0.003</td><td></td><td></td></tr></table>
d6e029ace420e2632c3a36d1edfd3d6b7bd07407a697a77fb3f31fd0ddfa25bc.png
complex
<table><tr><td></td><td colspan="5">Wealth quintiles</td><td></td></tr><tr><td>State</td><td>Lowest</td><td>Lower</td><td>Middle</td><td>Higher</td><td>Highest</td><td>N</td></tr><tr><td>Yobe</td><td>65.9</td><td>24.9</td><td>3.9</td><td>3.2</td><td>2.2</td><td>539</td></tr><tr><td>Zamfara</td><td>56.3</td><td>31.0</td><td>7.4</td><td>3.3</td><td>1.9</td><td>931</td></tr><tr><td>Sokoto</td><td>49.9</td><td>20.8</td><td>12.7</td><td>9.4</td><td>7.1</td><td>897</td></tr><tr><td>Borno</td><td>49.3</td><td>34.2</td><td>11.2</td><td>4.2</td><td>1.2</td><td>816</td></tr><tr><td>Kebbi</td><td>48.8</td><td>26.5</td><td>11.0</td><td>6.8</td><td>6.8</td><td>952</td></tr><tr><td>Jigawa</td><td>46.8</td><td>31.2</td><td>12.6</td><td>6.4</td><td>3.0</td><td>897</td></tr><tr><td>Taraba</td><td>45.9</td><td>28.6</td><td>12.0</td><td>6.2</td><td>7.3</td><td>936</td></tr><tr><td>Katsina</td><td>40.8</td><td>30.8</td><td>16.3</td><td>7.0</td><td>5.2</td><td>892</td></tr><tr><td>Gombe</td><td>36.7</td><td>27.9</td><td>15.6</td><td>11.2</td><td>8.6</td><td>795</td></tr><tr><td>Bauchi</td><td>34.6</td><td>26.9</td><td>18.9</td><td>11.9</td><td>7.6</td><td>866</td></tr><tr><td>Kano</td><td>31.3</td><td>23.2</td><td>18.3</td><td>12.5</td><td>14.7</td><td>672</td></tr><tr><td>Ebonyi</td><td>28.2</td><td>34.7</td><td>24.1</td><td>8.1</td><td>5.0</td><td>877</td></tr><tr><td>Benue</td><td>27.1</td><td>23.8</td><td>19.0</td><td>16.9</td><td>13.3</td><td>728</td></tr><tr><td>Adamawa</td><td>23.7</td><td>32.2</td><td>18.2</td><td>13.2</td><td>12.8</td><td>721</td></tr><tr><td>Nasarawa</td><td>23.4</td><td>37.0</td><td>25.8</td><td>8.2</td><td>5.6</td><td>765</td></tr><tr><td>Plateau</td><td>22.9</td><td>33.0</td><td>19.1</td><td>8.6</td><td>16.4</td><td>864</td></tr><tr><td>Niger</td><td>21.3</td><td>27.7</td><td>21.4</td><td>15.4</td><td>14.2</td><td>855</td></tr><tr><td>Kwara</td><td>12.3</td><td>10.2</td><td>18.8</td><td>31.1</td><td>27.5</td><td>861</td></tr><tr><td>Oyo</td><td>11.1</td><td>19.7</td><td>18.8</td><td>25.1</td><td>25.2</td><td>903</td></tr><tr><td>Kaduna</td><td>10.4</td><td>29.0</td><td>24.7</td><td>17.7</td><td>18.1</td><td>938</td></tr><tr><td>Bayelsa</td><td>8.4</td><td>19.5</td><td>26.2</td><td>25.1</td><td>20.8</td><td>821</td></tr><tr><td>Cross River</td><td>7.8</td><td>19.2</td><td>29.7</td><td>22.2</td><td>21.1</td><td>871</td></tr><tr><td>AkwaIbom</td><td>6.0</td><td>16.0</td><td>30.8</td><td>26.7</td><td>20.6</td><td>938</td></tr><tr><td>Rivers</td><td>5.9</td><td>8.7</td><td>19.7</td><td>29.0</td><td>36.7</td><td>645</td></tr><tr><td>Ondo</td><td>5.8</td><td>16.8</td><td>22.6</td><td>27.9</td><td>26.8</td><td>619</td></tr><tr><td>Kogi</td><td>4.2</td><td>15.0</td><td>30.3</td><td>27.2</td><td>23.3</td><td>838</td></tr><tr><td>Delta</td><td>4.0</td><td>7.4</td><td>24.2</td><td>28.0</td><td>36.3</td><td>900</td></tr><tr><td>Ogun</td><td>3.8</td><td>14.6</td><td>21.4</td><td>32.8</td><td>27.5</td><td>899</td></tr><tr><td>Ekiti</td><td>3.5</td><td>17.6</td><td>25.4</td><td>29.1</td><td>24.3</td><td>879</td></tr><tr><td>Enugu</td><td>3.3</td><td>16.4</td><td>29.9</td><td>22.7</td><td>27.7</td><td>669</td></tr><tr><td>Osun</td><td>2.4</td><td>4.3</td><td>21.2</td><td>42.1</td><td>30.0</td><td>921</td></tr><tr><td>Anambra</td><td>1.6</td><td>7.1</td><td>23.5</td><td>33.1</td><td>34.6</td><td>910</td></tr><tr><td>Edo</td><td>1.3</td><td>7.7</td><td>23.0</td><td>34.6</td><td>33.5</td><td>819</td></tr><tr><td>Abia</td><td>.8</td><td>6.9</td><td>26.7</td><td>31.6</td><td>34.2</td><td>919</td></tr><tr><td>FCT</td><td>.7</td><td>4.8</td><td>14.1</td><td>25.3</td><td>55.1</td><td>724</td></tr><tr><td>Imo</td><td>.4</td><td>3.5</td><td>27.6</td><td>40.5</td><td>28.0</td><td>926</td></tr><tr><td>Lagos</td><td>.0</td><td>1.6</td><td>10.0</td><td>30.3</td><td>58.1</td><td>852</td></tr></table>
<table><tr><td></td><td colspan="5">Wealth quintiles</td><td></td></tr><tr><td>State</td><td>Lowest</td><td>Lower</td><td>Middle</td><td>Higher</td><td>Highest</td><td>N</td></tr><tr><td>Yobe</td><td>65.9</td><td>24.9</td><td>3.9</td><td>3.2</td><td>2.2</td><td>539</td></tr></table>
<table><tr><td>Zamfara</td><td>56.3</td><td>31.0</td><td>7.4</td><td>3.3</td><td>1.9</td><td>931</td></tr><tr><td>Sokoto</td><td>49.9</td><td>20.8</td><td>12.7</td><td>9.4</td><td>7.1</td><td>897</td></tr><tr><td>Borno</td><td>49.3</td><td>34.2</td><td>11.2</td><td>4.2</td><td>1.2</td><td>816</td></tr><tr><td>Kebbi</td><td>48.8</td><td>26.5</td><td>11.0</td><td>6.8</td><td>6.8</td><td>952</td></tr><tr><td>Jigawa</td><td>46.8</td><td>31.2</td><td>12.6</td><td>6.4</td><td>3.0</td><td>897</td></tr><tr><td>Taraba</td><td>45.9</td><td>28.6</td><td>12.0</td><td>6.2</td><td>7.3</td><td>936</td></tr><tr><td>Katsina</td><td>40.8</td><td>30.8</td><td>16.3</td><td>7.0</td><td>5.2</td><td>892</td></tr><tr><td>Gombe</td><td>36.7</td><td>27.9</td><td>15.6</td><td>11.2</td><td>8.6</td><td>795</td></tr><tr><td>Bauchi</td><td>34.6</td><td>26.9</td><td>18.9</td><td>11.9</td><td>7.6</td><td>866</td></tr><tr><td>Kano</td><td>31.3</td><td>23.2</td><td>18.3</td><td>12.5</td><td>14.7</td><td>672</td></tr><tr><td>Ebonyi</td><td>28.2</td><td>34.7</td><td>24.1</td><td>8.1</td><td>5.0</td><td>877</td></tr><tr><td>Benue</td><td>27.1</td><td>23.8</td><td>19.0</td><td>16.9</td><td>13.3</td><td>728</td></tr><tr><td>Adamawa</td><td>23.7</td><td>32.2</td><td>18.2</td><td>13.2</td><td>12.8</td><td>721</td></tr><tr><td>Nasarawa</td><td>23.4</td><td>37.0</td><td>25.8</td><td>8.2</td><td>5.6</td><td>765</td></tr><tr><td>Plateau</td><td>22.9</td><td>33.0</td><td>19.1</td><td>8.6</td><td>16.4</td><td>864</td></tr><tr><td>Niger</td><td>21.3</td><td>27.7</td><td>21.4</td><td>15.4</td><td>14.2</td><td>855</td></tr><tr><td>Kwara</td><td>12.3</td><td>10.2</td><td>18.8</td><td>31.1</td><td>27.5</td><td>861</td></tr><tr><td>Oyo</td><td>11.1</td><td>19.7</td><td>18.8</td><td>25.1</td><td>25.2</td><td>903</td></tr><tr><td>Kaduna</td><td>10.4</td><td>29.0</td><td>24.7</td><td>17.7</td><td>18.1</td><td>938</td></tr><tr><td>Bayelsa</td><td>8.4</td><td>19.5</td><td>26.2</td><td>25.1</td><td>20.8</td><td>821</td></tr><tr><td>Cross River</td><td>7.8</td><td>19.2</td><td>29.7</td><td>22.2</td><td>21.1</td><td>871</td></tr><tr><td>AkwaIbom</td><td>6.0</td><td>16.0</td><td>30.8</td><td>26.7</td><td>20.6</td><td>938</td></tr><tr><td>Rivers</td><td>5.9</td><td>8.7</td><td>19.7</td><td>29.0</td><td>36.7</td><td>645</td></tr><tr><td>Ondo</td><td>5.8</td><td>16.8</td><td>22.6</td><td>27.9</td><td>26.8</td><td>619</td></tr><tr><td>Kogi</td><td>4.2</td><td>15.0</td><td>30.3</td><td>27.2</td><td>23.3</td><td>838</td></tr><tr><td>Delta</td><td>4.0</td><td>7.4</td><td>24.2</td><td>28.0</td><td>36.3</td><td>900</td></tr><tr><td>Ogun</td><td>3.8</td><td>14.6</td><td>21.4</td><td>32.8</td><td>27.5</td><td>899</td></tr><tr><td>Ekiti</td><td>3.5</td><td>17.6</td><td>25.4</td><td>29.1</td><td>24.3</td><td>879</td></tr><tr><td>Enugu</td><td>3.3</td><td>16.4</td><td>29.9</td><td>22.7</td><td>27.7</td><td>669</td></tr><tr><td>Osun</td><td>2.4</td><td>4.3</td><td>21.2</td><td>42.1</td><td>30.0</td><td>921</td></tr><tr><td>Anambra</td><td>1.6</td><td>7.1</td><td>23.5</td><td>33.1</td><td>34.6</td><td>910</td></tr><tr><td>Edo</td><td>1.3</td><td>7.7</td><td>23.0</td><td>34.6</td><td>33.5</td><td>819</td></tr><tr><td>Abia</td><td>.8</td><td>6.9</td><td>26.7</td><td>31.6</td><td>34.2</td><td>919</td></tr><tr><td>FCT</td><td>.7</td><td>4.8</td><td>14.1</td><td>25.3</td><td>55.1</td><td>724</td></tr><tr><td>Imo</td><td>.4</td><td>3.5</td><td>27.6</td><td>40.5</td><td>28.0</td><td>926</td></tr><tr><td>Lagos</td><td>.0</td><td>1.6</td><td>10.0</td><td>30.3</td><td>58.1</td><td>852</td></tr></table>
f552ef3ec3cc627948433b2196e8e9276243f011a9300294f7ef398133107d4e.png
simple
<table><tr><td>Declaration of minimodel</td><td>Explanation</td></tr><tr><td>&lt;SimulaDerivative name=&#8220;rootGrowthRate&#8221; function=&#8220;usePath&#8221; unit=&#8220;cm/day&#8221;&gt;</td><td>Declaration of a minimodel named rootGrowthRate which uses the plugin &#8220;usePath&#8221; to simulate a growth rate with the unit cm d<sup>&#8722;1</sup></td></tr><tr><td>&lt;SimulaConstant name=&#8220;path&#8221; type=&#8220;string&#8221;&gt; rootGrowth &lt;/SimulaConstant&gt;</td><td>Declaration of a minimodel named &#8220;path&#8221; which contains a string of the path to which &#8220;rootGrowthRate&#8221; needs to be coupled</td></tr><tr><td>&lt;SimulaConstant name=&#8220;multiplier&#8221;&gt; 0.1 &lt; /SimulaConstant&gt;</td><td>Declaration of a minimodel named &#8220;multiplier&#8221; which is a simple constant with which the result of minimodel named by &#8220;path&#8221; should be multiplied</td></tr><tr><td>&lt;/SimulaDerivative&gt;</td><td>Closing of the declaration of minimodel &#8220;rootGrowthRate&#8221;, so it is clear that &#8220;path&#8221; and &#8220;multiplier&#8221; are owned by it</td></tr><tr><td>&lt;SimulaVariable name=&#8220;rootGrowth&#8221; function=&#8220;useName+Rate&#8221; integrationFunction=&#8220;RungeKutta4&#8221; unit=&#8220;cm&#8221; &gt; 1. &lt;/SimulaVariable&gt;</td><td>Declaration of a minimodel named rootGrowth, which will use function &#8220;useName+Rate&#8221; to retrieve data and will integrate that data with the default integration function, RungeKutta4. Start value is 1</td></tr></table>
<table><tr><td>Declaration of minimodel</td></tr><tr><td><SimulaDerivative name=“rootGrowthRate” function=“usePath” unit=“cm/day”></td></tr><tr><td><SimulaConstant name=“path” type=“string”> rootGrowth </SimulaConstant></td></tr><tr><td><SimulaConstant name=“multiplier”> 0.1 < /SimulaConstant></td></tr><tr><td></SimulaDerivative></td></tr><tr><td><SimulaVariable name=“rootGrowth” function=“useName+Rate” integrationFunction=“RungeKutta4” unit=“cm” > 1. </SimulaVariable></td></tr></table>
<table><tr><td>Explanation</td></tr><tr><td>Declaration of a minimodel named rootGrowthRate which uses the plugin “usePath” to simulate a growth rate with the unit cm d−1</td></tr><tr><td>Declaration of a minimodel named “path” which contains a string of the path to which “rootGrowthRate” needs to be coupled</td></tr><tr><td>Declaration of a minimodel named “multiplier” which is a simple constant with which the result of minimodel named by “path” should be multiplied</td></tr><tr><td>Closing of the declaration of minimodel “rootGrowthRate”, so it is clear that “path” and “multiplier” are owned by it</td></tr><tr><td>Declaration of a minimodel named rootGrowth, which will use function “useName+Rate” to retrieve data and will integrate that data with the default integration function, RungeKutta4. Start value is 1</td></tr></table>
e430b38856c48bc250b2f9bb47195a6495729fee0360a684d2d2b7e92545c951.png
simple
<table><tr><td>Variables</td><td>Univariate analysis</td><td>Multivariate analysis</td></tr><tr><td> </td><td><i>p</i>value</td><td><i>p</i>value [OR]</td></tr><tr><td>Chemotherapy</td><td>0.443</td><td>0.752</td></tr><tr><td>Hypertension</td><td>0.805</td><td>0.782</td></tr><tr><td>Age</td><td>0.200</td><td>0.373</td></tr><tr><td>Breast volume</td><td>0.696</td><td>= 0.01504 [OR 1.00612 (0.99659 &#8211; 1.01588)]</td></tr><tr><td>Diabetes</td><td>0.149</td><td>0.568</td></tr><tr><td>Surgical deficits</td><td>0.107</td><td>= 0.00383 [OR 3.4577 (1.4914 &#8211; 8.0161)]</td></tr><tr><td>Boost administration</td><td>= 0.0001156</td><td>= 0.00543 [OR 0.9909 (0.98363 &#8211; 0.9982)]</td></tr><tr><td>V &gt; 100%</td><td>-</td><td>0.608</td></tr><tr><td>V &gt; 104%</td><td>-</td><td>0.323</td></tr><tr><td>V &gt; 107%</td><td>-</td><td>0.279</td></tr><tr><td>Boost V &gt; 100%</td><td>-</td><td>0.997</td></tr><tr><td>Boost V &gt; 104%</td><td>-</td><td>0.997</td></tr><tr><td>Boost V &gt; 107%</td><td>-</td><td>0.546</td></tr></table>
<table><tr><td>Variables</td><td>Univariate analysis</td><td>Multivariate analysis</td></tr><tr><td></td><td>pvalue</td><td>pvalue [OR]</td></tr><tr><td>Chemotherapy</td><td>0.443</td><td>0.752</td></tr><tr><td>Hypertension</td><td>0.805</td><td>0.782</td></tr><tr><td>Age</td><td>0.200</td><td>0.373</td></tr><tr><td>Breast volume</td><td>0.696</td><td>= 0.01504 [OR 1.00612 (0.99659 – 1.01588)]</td></tr><tr><td>Diabetes</td><td>0.149</td><td>0.568</td></tr><tr><td>Surgical deficits</td><td>0.107</td><td>= 0.00383 [OR 3.4577 (1.4914 – 8.0161)]</td></tr><tr><td>Boost administration</td><td>= 0.0001156</td><td>= 0.00543 [OR 0.9909 (0.98363 – 0.9982)]</td></tr></table>
<table><tr><td>V > 100%</td><td>-</td><td>0.608</td></tr><tr><td>V > 104%</td><td>-</td><td>0.323</td></tr><tr><td>V > 107%</td><td>-</td><td>0.279</td></tr><tr><td>Boost V > 100%</td><td>-</td><td>0.997</td></tr><tr><td>Boost V > 104%</td><td>-</td><td>0.997</td></tr><tr><td>Boost V > 107%</td><td>-</td><td>0.546</td></tr></table>
3f47eed305de66ead470b9d29ee46f9eaa01dc179a6aa8b97b0322cd201e097e.png
complex
<table><tr><td> Variable</td><td>TST + <i>N</i> (%)</td><td>TST &#8722; <i>N</i> (%)</td><td><i>P</i></td></tr><tr><td>Gender</td><td></td><td></td><td></td></tr><tr><td> Male</td><td>102 (50)</td><td>102 (50)</td><td rowspan="2"> 0.006</td></tr><tr><td> Female</td><td>16 (29.1)</td><td>39 (70.9)</td></tr><tr><td>Age (years)</td><td></td><td></td><td></td></tr><tr><td> &lt;60</td><td>99 (43.8)</td><td>127 (56.2)</td><td rowspan="2"> 0.135</td></tr><tr><td> &#8805;60</td><td>18 (58.1)</td><td>13 (41.9)</td></tr><tr><td>Marital status</td><td></td><td></td><td></td></tr><tr><td> Single</td><td>49 (40.2%)</td><td>73 (59.8%)</td><td></td></tr><tr><td> Married</td><td>38 (55.9%)</td><td>30 (44.1%)</td><td>0.158</td></tr><tr><td> Divorced or separated</td><td>22 (43.1%)</td><td>29 (56.9%)</td><td></td></tr><tr><td> Widowers</td><td>9 (56.2%)</td><td>7 (43.8%)</td><td></td></tr><tr><td>Immigrant</td><td></td><td></td><td></td></tr><tr><td> Yes</td><td>85 (49.7%)</td><td>86 (50.3%)</td><td rowspan="2"> 0.062</td></tr><tr><td> No</td><td>33 (37.5%)</td><td>55 (62.5%)</td></tr><tr><td>Italian National Health Service</td><td></td><td></td><td></td></tr><tr><td> No</td><td>59 (46.5%)</td><td>68 (53.5%)</td><td></td></tr><tr><td> Yes</td><td>47 (43.5%)</td><td>61 (56.5%)</td><td>0.831</td></tr><tr><td> Unknown</td><td>1 (33.3%)</td><td>2 (66.7%)</td><td></td></tr><tr><td>Temporary Present Foreigners</td><td></td><td></td><td></td></tr><tr><td> No</td><td>31 (49.2)</td><td>32 (50.8)</td><td></td></tr><tr><td> Yes</td><td>7 (41.2)</td><td>10 (58.8)</td><td>0.473</td></tr><tr><td> Not Known</td><td>3 (75)</td><td>1 (25)</td><td></td></tr><tr><td>Educational level</td><td></td><td></td><td></td></tr><tr><td> No instruction title</td><td>5 (38.5)</td><td>8 (61.5)</td><td></td></tr><tr><td> Primary school</td><td>54 (43.5)</td><td>70 (56.5)</td><td>0.585</td></tr><tr><td> Secondary school</td><td>51 (50)</td><td>51 (50)</td><td></td></tr><tr><td> Degree</td><td>5 (33.3)</td><td>7 (66.7)</td><td></td></tr><tr><td>Employment</td><td></td><td></td><td></td></tr><tr><td> No</td><td>86 (44.6)</td><td>107 (55.4)</td><td rowspan="2"> 0.661</td></tr><tr><td> Yes</td><td>31 (47.7)</td><td>34 (52.3)</td></tr><tr><td>Previous TBC diagnosis</td><td></td><td></td><td></td></tr><tr><td> No</td><td>114 (46.2)</td><td>133 (53.8)</td><td rowspan="2"> 0.115</td></tr><tr><td> Yes</td><td>3 (75)</td><td>1 (25)</td></tr><tr><td>Smoking habit</td><td></td><td></td><td></td></tr><tr><td> No smoker</td><td>42 (42.4)</td><td>57 (57.6)</td><td></td></tr><tr><td> Smoker</td><td>72 (49)</td><td>75 (51)</td><td>0.328</td></tr><tr><td> Former smoker</td><td>4 (30.8)</td><td>9 (69.2)</td><td></td></tr><tr><td>Alcohol abuse</td><td></td><td></td><td></td></tr><tr><td> No</td><td>98 (44.3)</td><td>123 (55.7)</td><td></td></tr><tr><td> Yes</td><td>11 (52.4)</td><td>10 (47.6)</td><td>0.743</td></tr><tr><td> Exalcohol abuser</td><td>5 (50)</td><td>5 (50)</td><td></td></tr><tr><td>Illicit drug use</td><td></td><td></td><td></td></tr><tr><td> No</td><td>105 (45.5)</td><td>126 (54.5)</td><td></td></tr><tr><td> Yes</td><td>1 (33.3)</td><td>2 (66.7)</td><td>0.833</td></tr><tr><td> Former drug user</td><td>3 (37.5)</td><td>5 (62.5)</td><td></td></tr><tr><td>Obesity</td><td></td><td></td><td></td></tr><tr><td> No</td><td>87 (42.9)</td><td>116 (57.1)</td><td rowspan="2"> 0.096</td></tr><tr><td> Yes</td><td>30 (55.6)</td><td>24 (44.4)</td></tr></table>
<table><tr><td>Variable</td><td>TST + N (%)</td><td>TST − N (%)</td><td>P</td></tr><tr><td>Gender</td><td></td><td></td><td></td></tr><tr><td>Male</td><td>102 (50)</td><td>102 (50)</td><td rowspan="2">0.006</td></tr><tr><td>Female</td><td>16 (29.1)</td><td>39 (70.9)</td></tr><tr><td>Age (years)</td><td></td><td></td><td></td></tr><tr><td><60</td><td>99 (43.8)</td><td>127 (56.2)</td><td rowspan="2">0.135</td></tr><tr><td>≥60</td><td>18 (58.1)</td><td>13 (41.9)</td></tr><tr><td>Marital status</td><td></td><td></td><td></td></tr></table>
<table><tr><td>Single</td><td>49 (40.2%)</td><td>73 (59.8%)</td><td></td></tr><tr><td>Married</td><td>38 (55.9%)</td><td>30 (44.1%)</td><td>0.158</td></tr><tr><td>Divorced or separated</td><td>22 (43.1%)</td><td>29 (56.9%)</td><td></td></tr><tr><td>Widowers</td><td>9 (56.2%)</td><td>7 (43.8%)</td><td></td></tr><tr><td>Immigrant</td><td></td><td></td><td></td></tr><tr><td>Yes</td><td>85 (49.7%)</td><td>86 (50.3%)</td><td rowspan="2">0.062</td></tr><tr><td>No</td><td>33 (37.5%)</td><td>55 (62.5%)</td></tr><tr><td>Italian National Health Service</td><td></td><td></td><td></td></tr><tr><td>No</td><td>59 (46.5%)</td><td>68 (53.5%)</td><td></td></tr><tr><td>Yes</td><td>47 (43.5%)</td><td>61 (56.5%)</td><td>0.831</td></tr><tr><td>Unknown</td><td>1 (33.3%)</td><td>2 (66.7%)</td><td></td></tr><tr><td>Temporary Present Foreigners</td><td></td><td></td><td></td></tr><tr><td>No</td><td>31 (49.2)</td><td>32 (50.8)</td><td></td></tr><tr><td>Yes</td><td>7 (41.2)</td><td>10 (58.8)</td><td>0.473</td></tr><tr><td>Not Known</td><td>3 (75)</td><td>1 (25)</td><td></td></tr><tr><td>Educational level</td><td></td><td></td><td></td></tr><tr><td>No instruction title</td><td>5 (38.5)</td><td>8 (61.5)</td><td></td></tr><tr><td>Primary school</td><td>54 (43.5)</td><td>70 (56.5)</td><td>0.585</td></tr><tr><td>Secondary school</td><td>51 (50)</td><td>51 (50)</td><td></td></tr><tr><td>Degree</td><td>5 (33.3)</td><td>7 (66.7)</td><td></td></tr><tr><td>Employment</td><td></td><td></td><td></td></tr><tr><td>No</td><td>86 (44.6)</td><td>107 (55.4)</td><td rowspan="2">0.661</td></tr><tr><td>Yes</td><td>31 (47.7)</td><td>34 (52.3)</td></tr><tr><td>Previous TBC diagnosis</td><td></td><td></td><td></td></tr><tr><td>No</td><td>114 (46.2)</td><td>133 (53.8)</td><td rowspan="2">0.115</td></tr><tr><td>Yes</td><td>3 (75)</td><td>1 (25)</td></tr><tr><td>Smoking habit</td><td></td><td></td><td></td></tr><tr><td>No smoker</td><td>42 (42.4)</td><td>57 (57.6)</td><td></td></tr><tr><td>Smoker</td><td>72 (49)</td><td>75 (51)</td><td>0.328</td></tr><tr><td>Former smoker</td><td>4 (30.8)</td><td>9 (69.2)</td><td></td></tr><tr><td>Alcohol abuse</td><td></td><td></td><td></td></tr><tr><td>No</td><td>98 (44.3)</td><td>123 (55.7)</td><td></td></tr><tr><td>Yes</td><td>11 (52.4)</td><td>10 (47.6)</td><td>0.743</td></tr><tr><td>Exalcohol abuser</td><td>5 (50)</td><td>5 (50)</td><td></td></tr><tr><td>Illicit drug use</td><td></td><td></td><td></td></tr><tr><td>No</td><td>105 (45.5)</td><td>126 (54.5)</td><td></td></tr><tr><td>Yes</td><td>1 (33.3)</td><td>2 (66.7)</td><td>0.833</td></tr><tr><td>Former drug user</td><td>3 (37.5)</td><td>5 (62.5)</td><td></td></tr><tr><td>Obesity</td><td></td><td></td><td></td></tr><tr><td>No</td><td>87 (42.9)</td><td>116 (57.1)</td><td rowspan="2">0.096</td></tr><tr><td>Yes</td><td>30 (55.6)</td><td>24 (44.4)</td></tr></table>
b55240e5bc687a8c2e7c2c3c13537871e1bb0b49c2a117065c7e035c3509cfa4.png
complex
<table><tr><td>Variable</td><td>Intervention</td><td>Sham</td><td><i>p</i><sup>*</sup></td></tr><tr><td>N</td><td>24</td><td>10</td><td>&#8211;</td></tr><tr><td>Age [years]</td><td>57 (12)</td><td>65 (12)</td><td>0.079</td></tr><tr><td>Gender M/F (%)</td><td>67/33%</td><td>70/30%</td><td>0.999</td></tr><tr><td>Education [years]</td><td>10 (4)</td><td>10 (4)</td><td>0.869</td></tr><tr><td>Affected hemisphere R/L (%)</td><td>50/50%</td><td>40/60%</td><td>0.715</td></tr><tr><td>Etiopathogenesis (%)</td><td></td><td></td><td>0.999</td></tr><tr><td>Ischemic</td><td>71%</td><td>70%</td><td></td></tr><tr><td>Hemorrhagic</td><td>29%</td><td>30%</td><td></td></tr><tr><td>Previous stroke events (%)</td><td>21%</td><td>30%</td><td>0.666</td></tr><tr><td>Lesion localization (%)</td><td></td><td></td><td>0.735</td></tr><tr><td>Cortical</td><td>25%</td><td>10%</td><td></td></tr><tr><td>Subcortical</td><td>62%</td><td>80%</td><td></td></tr><tr><td>Both</td><td>13%</td><td>10%</td><td></td></tr><tr><td>Time from stroke [mos]</td><td>41 (39)</td><td>37 (32)</td><td>0.797</td></tr><tr><td>Smoke (%)</td><td>25%</td><td>10%</td><td>0.644</td></tr><tr><td>Hypertension (%)</td><td>72%</td><td>70%</td><td>0.999</td></tr><tr><td>Diabetes (%)</td><td>8%</td><td>30%</td><td>0.138</td></tr><tr><td>Dyslipidemia (%)</td><td>38%</td><td>40%</td><td>0.999</td></tr><tr><td>Stroke familiar history (%)</td><td>21%</td><td>30%</td><td>0.666</td></tr><tr><td colspan="4">THERAPY</td></tr><tr><td>Antidepressant</td><td>71%</td><td>40%</td><td>0.130</td></tr><tr><td>Antihypertensive</td><td>58%</td><td>60%</td><td>0.999</td></tr><tr><td>Antiplatelet</td><td>79%</td><td>70%</td><td>0.666</td></tr><tr><td colspan="4">NIBS SEQUENCE</td></tr><tr><td>TMS-tDCS</td><td>8</td><td>&#8211;</td><td>&#8211;</td></tr><tr><td>tDCS-TMS</td><td>16</td><td></td><td></td></tr><tr><td colspan="4">SIDE EFFECTS IN 10 SESSIONS<sup>**</sup></td></tr><tr><td>TMS</td><td>4</td><td></td><td>&#8211;</td></tr><tr><td>tDCS</td><td>6</td><td>3</td><td></td></tr><tr><td>Drop outs (%)</td><td>24%</td><td>0%</td><td>&#8211;</td></tr></table>
<table><tr><td>Variable</td><td>Intervention</td><td>Sham</td><td>p*</td></tr><tr><td>N</td><td>24</td><td>10</td><td>–</td></tr><tr><td>Age [years]</td><td>57 (12)</td><td>65 (12)</td><td>0.079</td></tr><tr><td>Gender M/F (%)</td><td>67/33%</td><td>70/30%</td><td>0.999</td></tr><tr><td>Education [years]</td><td>10 (4)</td><td>10 (4)</td><td>0.869</td></tr><tr><td>Affected hemisphere R/L (%)</td><td>50/50%</td><td>40/60%</td><td>0.715</td></tr><tr><td>Etiopathogenesis (%)</td><td></td><td></td><td>0.999</td></tr><tr><td>Ischemic</td><td>71%</td><td>70%</td><td></td></tr><tr><td>Hemorrhagic</td><td>29%</td><td>30%</td><td></td></tr><tr><td>Previous stroke events (%)</td><td>21%</td><td>30%</td><td>0.666</td></tr><tr><td>Lesion localization (%)</td><td></td><td></td><td>0.735</td></tr><tr><td>Cortical</td><td>25%</td><td>10%</td><td></td></tr><tr><td>Subcortical</td><td>62%</td><td>80%</td><td></td></tr><tr><td>Both</td><td>13%</td><td>10%</td><td></td></tr><tr><td>Time from stroke [mos]</td><td>41 (39)</td><td>37 (32)</td><td>0.797</td></tr><tr><td>Smoke (%)</td><td>25%</td><td>10%</td><td>0.644</td></tr><tr><td>Hypertension (%)</td><td>72%</td><td>70%</td><td>0.999</td></tr><tr><td>Diabetes (%)</td><td>8%</td><td>30%</td><td>0.138</td></tr><tr><td>Dyslipidemia (%)</td><td>38%</td><td>40%</td><td>0.999</td></tr></table>
<table><tr><td>Stroke familiar history (%)</td><td>21%</td><td>30%</td><td>0.666</td></tr><tr><td colspan="4">THERAPY</td></tr><tr><td>Antidepressant</td><td>71%</td><td>40%</td><td>0.130</td></tr><tr><td>Antihypertensive</td><td>58%</td><td>60%</td><td>0.999</td></tr><tr><td>Antiplatelet</td><td>79%</td><td>70%</td><td>0.666</td></tr><tr><td colspan="4">NIBS SEQUENCE</td></tr><tr><td>TMS-tDCS</td><td>8</td><td>–</td><td>–</td></tr><tr><td>tDCS-TMS</td><td>16</td><td></td><td></td></tr><tr><td colspan="4">SIDE EFFECTS IN 10 SESSIONS**</td></tr><tr><td>TMS</td><td>4</td><td></td><td>–</td></tr><tr><td>tDCS</td><td>6</td><td>3</td><td></td></tr><tr><td>Drop outs (%)</td><td>24%</td><td>0%</td><td>–</td></tr></table>
bd9d058772ee0f2072bff5d564f74e3cef6ef39706ea2a131df34b52c0dd00fa.png
complex
<table><tr><td rowspan="2"></td><td colspan="3">Total cohort</td><td colspan="3">Matched cohort</td></tr><tr><td>LAP (<i>n</i> = 85)</td><td>OP (<i>n</i> = 195)</td><td><i>P</i></td><td>LAP (<i>n</i> = 71)</td><td>OP (<i>n</i> = 71)</td><td><i>P</i></td></tr><tr><td colspan="7">Age (years)</td></tr><tr><td>Median (IQR)</td><td>82.0 (80&#8211;84)</td><td>82.0 (81&#8211;85)</td><td>0.055</td><td>82.0 (81&#8211;84)</td><td>82.0 (81&#8211;84)</td><td>0.711</td></tr><tr><td>Sex</td><td></td><td></td><td>0.552</td><td></td><td></td><td>1.000</td></tr><tr><td>Male</td><td>46 (54.1)</td><td>98 (50.3)</td><td></td><td>40 (56.3)</td><td>40 (56.3)</td><td></td></tr><tr><td>Female</td><td>39 (45.9)</td><td>97 (49.7)</td><td></td><td>31 (43.7)</td><td>31 (43.7)</td><td></td></tr><tr><td colspan="7">BMI (kg/m<sup>2</sup>)</td></tr><tr><td>Median (IQR)</td><td>22.2 (20.6&#8211;24.1)</td><td>21.6 (19.5&#8211;23.6)</td><td>0.093</td><td>21.9 (20.4&#8211;24.2)</td><td>22.0 (20.6&#8211;24.5)</td><td>0.901</td></tr><tr><td>ASA score</td><td></td><td></td><td>0.882</td><td></td><td></td><td>0.396</td></tr><tr><td>1</td><td>13 (15.3)</td><td>35 (17.9)</td><td></td><td>12 (16.9)</td><td>16 (22.5)</td><td></td></tr><tr><td>2</td><td>56 (65.9)</td><td>120 (61.5)</td><td></td><td>45 (63.4)</td><td>37 (52.1)</td><td></td></tr><tr><td>3</td><td>16 (18.8)</td><td>38 (19.5)</td><td></td><td>14 (19.7)</td><td>18 (25.4)</td><td></td></tr><tr><td>4</td><td>0 (0.0)</td><td>2 (1.0)</td><td></td><td></td><td></td><td></td></tr><tr><td>Comorbidity</td><td>55 (64.7)</td><td>108 (55.4)</td><td>0.146</td><td>44 (62.0)</td><td>40 (56.3)</td><td>0.495</td></tr><tr><td>Hypertension</td><td>49 (57.6)</td><td>90 (46.2)</td><td></td><td>40 (56.3)</td><td>34 (47.9)</td><td></td></tr><tr><td>Diabetes mellitus</td><td>10 (11.8)</td><td>26 (13.3)</td><td></td><td>10 (14.1)</td><td>10 (14.1)</td><td></td></tr><tr><td>Cardiovascular disease</td><td>8 (9.4)</td><td>10 (5.1)</td><td></td><td>4 (5.6)</td><td>3 (4.2)</td><td></td></tr><tr><td>Cerebrovascular disease</td><td>4 (4.7)</td><td>7 (3.6)</td><td></td><td>2 (2.8)</td><td>5 (7.0)</td><td></td></tr><tr><td>Pulmonary disease</td><td>3 (3.5)</td><td>4 (2.1)</td><td></td><td>2 (2.8)</td><td>0 (0.0)</td><td></td></tr><tr><td>TNM Stage</td><td></td><td></td><td>0.002</td><td></td><td></td><td>0.978</td></tr><tr><td>I</td><td>26 (30.6)</td><td>25 (12.8)</td><td></td><td>19 (26.8)</td><td>18 (25.4)</td><td></td></tr><tr><td>II</td><td>28 (32.9)</td><td>77 (39.5)</td><td></td><td>24 (33.8)</td><td>24 (33.8)</td><td></td></tr><tr><td>III</td><td>31 (36.5)</td><td>93 (47.7)</td><td></td><td>28 (39.4)</td><td>29 (40.8)</td><td></td></tr><tr><td>Tumor location</td><td></td><td></td><td>0.007</td><td></td><td></td><td>0.913</td></tr><tr><td>Right colon</td><td>19 (22.4)</td><td>61 (31.3)</td><td></td><td>17 (23.9)</td><td>15 (21.1)</td><td></td></tr><tr><td>Left colon</td><td>44 (51.8)</td><td>62 (31.8)</td><td></td><td>34 (47.9)</td><td>36 (50.7)</td><td></td></tr><tr><td>Rectum</td><td>22 (25.9)</td><td>72 (36.9)</td><td></td><td>20 (28.2)</td><td>20 (28.2)</td><td></td></tr><tr><td>Preoperative CEA (ng/mL)</td><td></td><td></td><td>0.179</td><td></td><td></td><td>0.579</td></tr><tr><td>&#8804;5</td><td>59 (75.6)</td><td>117 (67.2)</td><td></td><td>52 (73.2)</td><td>49 (69.0)</td><td></td></tr><tr><td>&gt;5</td><td>19 (24.4)</td><td>57 (32.8)</td><td></td><td>19 (26.8)</td><td>22 (31.0)</td><td></td></tr></table>
<table><tr><td rowspan="2"></td><td colspan="3">Total cohort</td><td>Matched cohort</td></tr><tr><td>LAP (n = 85)</td><td>OP (n = 195)</td><td>P</td><td>LAP (n = 71)</td></tr><tr><td colspan="5">Age (years)</td></tr><tr><td>Median (IQR)</td><td>82.0 (80–84)</td><td>82.0 (81–85)</td><td>0.055</td><td>82.0 (81–84)</td></tr><tr><td>Sex</td><td></td><td></td><td>0.552</td><td></td></tr><tr><td>Male</td><td>46 (54.1)</td><td>98 (50.3)</td><td></td><td>40 (56.3)</td></tr><tr><td>Female</td><td>39 (45.9)</td><td>97 (49.7)</td><td></td><td>31 (43.7)</td></tr><tr><td colspan="5">BMI (kg/m2)</td></tr><tr><td>Median (IQR)</td><td>22.2 (20.6–24.1)</td><td>21.6 (19.5–23.6)</td><td>0.093</td><td>21.9 (20.4–24.2)</td></tr><tr><td>ASA score</td><td></td><td></td><td>0.882</td><td></td></tr><tr><td>1</td><td>13 (15.3)</td><td>35 (17.9)</td><td></td><td>12 (16.9)</td></tr><tr><td>2</td><td>56 (65.9)</td><td>120 (61.5)</td><td></td><td>45 (63.4)</td></tr><tr><td>3</td><td>16 (18.8)</td><td>38 (19.5)</td><td></td><td>14 (19.7)</td></tr><tr><td>4</td><td>0 (0.0)</td><td>2 (1.0)</td><td></td><td></td></tr><tr><td>Comorbidity</td><td>55 (64.7)</td><td>108 (55.4)</td><td>0.146</td><td>44 (62.0)</td></tr><tr><td>Hypertension</td><td>49 (57.6)</td><td>90 (46.2)</td><td></td><td>40 (56.3)</td></tr><tr><td>Diabetes mellitus</td><td>10 (11.8)</td><td>26 (13.3)</td><td></td><td>10 (14.1)</td></tr><tr><td>Cardiovascular disease</td><td>8 (9.4)</td><td>10 (5.1)</td><td></td><td>4 (5.6)</td></tr><tr><td>Cerebrovascular disease</td><td>4 (4.7)</td><td>7 (3.6)</td><td></td><td>2 (2.8)</td></tr><tr><td>Pulmonary disease</td><td>3 (3.5)</td><td>4 (2.1)</td><td></td><td>2 (2.8)</td></tr><tr><td>TNM Stage</td><td></td><td></td><td>0.002</td><td></td></tr><tr><td>I</td><td>26 (30.6)</td><td>25 (12.8)</td><td></td><td>19 (26.8)</td></tr><tr><td>II</td><td>28 (32.9)</td><td>77 (39.5)</td><td></td><td>24 (33.8)</td></tr><tr><td>III</td><td>31 (36.5)</td><td>93 (47.7)</td><td></td><td>28 (39.4)</td></tr><tr><td>Tumor location</td><td></td><td></td><td>0.007</td><td></td></tr><tr><td>Right colon</td><td>19 (22.4)</td><td>61 (31.3)</td><td></td><td>17 (23.9)</td></tr><tr><td>Left colon</td><td>44 (51.8)</td><td>62 (31.8)</td><td></td><td>34 (47.9)</td></tr><tr><td>Rectum</td><td>22 (25.9)</td><td>72 (36.9)</td><td></td><td>20 (28.2)</td></tr><tr><td>Preoperative CEA (ng/mL)</td><td></td><td></td><td>0.179</td><td></td></tr><tr><td>≤5</td><td>59 (75.6)</td><td>117 (67.2)</td><td></td><td>52 (73.2)</td></tr><tr><td>>5</td><td>19 (24.4)</td><td>57 (32.8)</td><td></td><td>19 (26.8)</td></tr></table>
<table><tr><td colspan="2">Matched cohort</td></tr><tr><td>OP (n = 71)</td><td>P</td></tr><tr><td colspan="2">Age (years)</td></tr><tr><td>82.0 (81–84)</td><td>0.711</td></tr><tr><td></td><td>1.000</td></tr><tr><td>40 (56.3)</td><td></td></tr><tr><td>31 (43.7)</td><td></td></tr><tr><td colspan="2">BMI (kg/m2)</td></tr><tr><td>22.0 (20.6–24.5)</td><td>0.901</td></tr><tr><td></td><td>0.396</td></tr><tr><td>16 (22.5)</td><td></td></tr><tr><td>37 (52.1)</td><td></td></tr><tr><td>18 (25.4)</td><td></td></tr><tr><td></td><td></td></tr><tr><td>40 (56.3)</td><td>0.495</td></tr><tr><td>34 (47.9)</td><td></td></tr><tr><td>10 (14.1)</td><td></td></tr><tr><td>3 (4.2)</td><td></td></tr><tr><td>5 (7.0)</td><td></td></tr><tr><td>0 (0.0)</td><td></td></tr><tr><td></td><td>0.978</td></tr><tr><td>18 (25.4)</td><td></td></tr><tr><td>24 (33.8)</td><td></td></tr><tr><td>29 (40.8)</td><td></td></tr><tr><td></td><td>0.913</td></tr><tr><td>15 (21.1)</td><td></td></tr><tr><td>36 (50.7)</td><td></td></tr><tr><td>20 (28.2)</td><td></td></tr><tr><td></td><td>0.579</td></tr><tr><td>49 (69.0)</td><td></td></tr><tr><td>22 (31.0)</td><td></td></tr></table>
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simple
<table><tr><td>Interaction</td><td>Notes</td><td>Reference</td></tr><tr><td>IL-1&#945; and IL-1&#946; induce autophagy</td><td>Induction of autophagy by IL-1 family cytokines suggests a potential negative feedback loop for the control of inflammation by autophagy, as well as a possible anti-microbial response mediated by inflammatory cytokines</td><td>Shi and Kehrl (2010)</td></tr><tr><td>Inhibition of autophagy increases IL-1&#945;, IL-1&#946;, and IL-18 secretion</td><td>Inhibition of (or deficiency in) autophagy leads to increased secretion of IL-1 family cytokines in response to TLR ligands and <i>Mycobacterium tuberculosis</i>. This is dependent on TRIF (in mice), reactive oxygen species, and mitochondrial DNA. These results suggest that autophagy normally regulates endogenous factors that would otherwise induce inflammasome assembly, caspase-1 activation, and subsequent processing and secretion of IL-1&#946; and IL-18. In humans, regulation of IL-1&#946; by autophagy occurs at the transcriptional level</td><td>Saitoh et al. (2008), Crisan et al. (2011), Harris et al. (2011), Kleinnijenhuis et al. (2011), Nakahira et al. (2011), Zhou et al. (2011a)</td></tr><tr><td>Induction of autophagy reduces IL-1&#946; secretion <i>in vitro</i> and <i>in vivo</i></td><td>Induction of autophagy with drugs (e.g., rapamycin) or starvation reduces secretion of IL-1&#946; by macrophages and dendritic cells in response to LPS with alum or ATP or in response to <i>Mycobacterium tuberculosis</i>. Induction of autophagy also decreases intracellular levels of pro-IL-1&#946;. In a mouse model of LPS-induced sepsis, rapamycin decreases serum levels of IL-1&#946;.</td><td>Crisan et al. (2011), Harris et al. (2011), Shi et al. (2012)</td></tr><tr><td>Autophagosomes sequester and degrade IL-1&#946; and inflammasome components</td><td>In macrophages stimulated with TLR ligands, autophagosomes sequester IL-1&#946;. The inflammasome component ASC is ubiquitinated in response to inflammasome activation and delivered to autophagosomes. NLRP3 and AIM2 are also sequestered by autophagosomes</td><td>Harris et al. (2011), Shi et al. (2012)</td></tr><tr><td>Activation of the NLRP3 and AIM2 inflammasomes induces autophagosome formation</td><td>Induction of the AIM2 inflammasome by transfection of macrophages with poly(dA:dT) or the NLRP3 inflammasome with uric acid crystals or nigericin leads to an increase in autophagosome formation</td><td>Shi et al. (2012)</td></tr><tr><td>Autophagy can act as secretory pathway for the release of IL-1&#946;</td><td>Induction of inflammasome activation in parallel with autophagy induction can lead to an increase in IL-1&#946; secretion. This novel secretory pathway is dependent on inflammasome assembly, Atg5, Rab8a, and GRASP55 (GORASP2; a mammalian Golgi reassembly stacking protein paralog)</td><td>Dupont et al. (2011)</td></tr></table>
<table><tr><td>Interaction</td></tr><tr><td>IL-1α and IL-1β induce autophagy</td></tr><tr><td>Inhibition of autophagy increases IL-1α, IL-1β, and IL-18 secretion</td></tr><tr><td>Induction of autophagy reduces IL-1β secretion in vitro and in vivo</td></tr><tr><td>Autophagosomes sequester and degrade IL-1β and inflammasome components</td></tr><tr><td>Activation of the NLRP3 and AIM2 inflammasomes induces autophagosome formation</td></tr><tr><td>Autophagy can act as secretory pathway for the release of IL-1β</td></tr></table>
<table><tr><td>Notes</td><td>Reference</td></tr><tr><td>Induction of autophagy by IL-1 family cytokines suggests a potential negative feedback loop for the control of inflammation by autophagy, as well as a possible anti-microbial response mediated by inflammatory cytokines</td><td>Shi and Kehrl (2010)</td></tr><tr><td>Inhibition of (or deficiency in) autophagy leads to increased secretion of IL-1 family cytokines in response to TLR ligands and Mycobacterium tuberculosis. This is dependent on TRIF (in mice), reactive oxygen species, and mitochondrial DNA. These results suggest that autophagy normally regulates endogenous factors that would otherwise induce inflammasome assembly, caspase-1 activation, and subsequent processing and secretion of IL-1β and IL-18. In humans, regulation of IL-1β by autophagy occurs at the transcriptional level</td><td>Saitoh et al. (2008), Crisan et al. (2011), Harris et al. (2011), Kleinnijenhuis et al. (2011), Nakahira et al. (2011), Zhou et al. (2011a)</td></tr><tr><td>Induction of autophagy with drugs (e.g., rapamycin) or starvation reduces secretion of IL-1β by macrophages and dendritic cells in response to LPS with alum or ATP or in response to Mycobacterium tuberculosis. Induction of autophagy also decreases intracellular levels of pro-IL-1β. In a mouse model of LPS-induced sepsis, rapamycin decreases serum levels of IL-1β.</td><td>Crisan et al. (2011), Harris et al. (2011), Shi et al. (2012)</td></tr><tr><td>In macrophages stimulated with TLR ligands, autophagosomes sequester IL-1β. The inflammasome component ASC is ubiquitinated in response to inflammasome activation and delivered to autophagosomes. NLRP3 and AIM2 are also sequestered by autophagosomes</td><td>Harris et al. (2011), Shi et al. (2012)</td></tr><tr><td>Induction of the AIM2 inflammasome by transfection of macrophages with poly(dA:dT) or the NLRP3 inflammasome with uric acid crystals or nigericin leads to an increase in autophagosome formation</td><td>Shi et al. (2012)</td></tr><tr><td>Induction of inflammasome activation in parallel with autophagy induction can lead to an increase in IL-1β secretion. This novel secretory pathway is dependent on inflammasome assembly, Atg5, Rab8a, and GRASP55 (GORASP2; a mammalian Golgi reassembly stacking protein paralog)</td><td>Dupont et al. (2011)</td></tr></table>
b5f61f5b2e286bb06eed4cd8014823672748836a74483b38bf0b2ba5e6d7368c.png
simple
<table><tr><td>First Author Year (Ref)</td><td>Study Years</td><td>AA, <i>n </i></td><td>Caucasian, <i>n </i></td><td>Age, yrs</td><td>Population</td><td>Study design</td><td>Enrollment states</td></tr><tr><td>Marcus et al. 2010 [7]</td><td>1989-1999</td><td>804</td><td>4,543</td><td>&gt;65</td><td>Older population</td><td>Cohort</td><td>15 U.S. states**, Washington D.C.</td></tr><tr><td>Go et al. 2001 [16]</td><td>1996-1997</td><td>39,579</td><td>519,714</td><td>&gt;50*</td><td>General population</td><td>Cross-sectional</td><td>California</td></tr><tr><td>Alonso et al. 2009 [17]</td><td>1987&#8211;2004</td><td>4,115</td><td>11,292</td><td>&gt;55*</td><td>General population</td><td>Cohort</td><td>Maryland,</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>Minnesota,</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>Mississippi,</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>N. Carolina</td></tr><tr><td>Afzal et al. 1999 [18]</td><td>1996</td><td>113</td><td>50</td><td>&gt;35*</td><td>Heart failure</td><td>Cohort</td><td>Michigan</td></tr><tr><td>Ruo et al. 2004 [19]</td><td>1999-2000</td><td>223</td><td>1,150</td><td>&gt;35*</td><td>Heart failure</td><td>Cohort</td><td>California</td></tr><tr><td>Winkelmayer et al. 2011 [20]</td><td>1992&#8211;2006</td><td>90,217</td><td>121,698</td><td>&gt;30*</td><td>Hemodialysis</td><td>Cohort</td><td>United States</td></tr><tr><td>Upshaw Jr. 2002 [21]</td><td>1996&#8211;1998</td><td>922</td><td>1,201</td><td>&gt;20</td><td>Hospitalized patients</td><td>Cohort</td><td>Georgia</td></tr><tr><td>Shen et al. 2010 [22]</td><td>2008</td><td>40,293</td><td>191,860</td><td>&gt;60</td><td>Older population</td><td>Cross-sectional</td><td>California</td></tr><tr><td>Smith et al. 2006 [23]</td><td>1993&#8211;2005</td><td>644</td><td>1,932</td><td>&gt;25*</td><td>Post-CABG</td><td>Case control</td><td>Ohio</td></tr><tr><td>Lahiri et al. 2011 [24]</td><td>2004&#8211;2008</td><td>270</td><td>731</td><td>&gt;25*</td><td>Post-CABG</td><td>Cohort</td><td>Michigan</td></tr></table>
<table><tr><td>First Author Year (Ref)</td><td>Study Years</td><td>AA, n</td><td>Caucasian, n</td><td>Age, yrs</td><td>Population</td><td>Study design</td><td>Enrollment states</td></tr><tr><td>Marcus et al. 2010 [7]</td><td>1989-1999</td><td>804</td><td>4,543</td><td>>65</td><td>Older population</td><td>Cohort</td><td>15 U.S. states**, Washington D.C.</td></tr><tr><td>Go et al. 2001 [16]</td><td>1996-1997</td><td>39,579</td><td>519,714</td><td>>50*</td><td>General population</td><td>Cross-sectional</td><td>California</td></tr><tr><td>Alonso et al. 2009 [17]</td><td>1987–2004</td><td>4,115</td><td>11,292</td><td>>55*</td><td>General population</td><td>Cohort</td><td>Maryland,</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>Minnesota,</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>Mississippi,</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>N. Carolina</td></tr><tr><td>Afzal et al. 1999 [18]</td><td>1996</td><td>113</td><td>50</td><td>>35*</td><td>Heart failure</td><td>Cohort</td><td>Michigan</td></tr><tr><td>Ruo et al. 2004 [19]</td><td>1999-2000</td><td>223</td><td>1,150</td><td>>35*</td><td>Heart failure</td><td>Cohort</td><td>California</td></tr></table>
<table><tr><td>First Author Year (Ref)</td><td>Study Years</td><td>AA, n</td><td>Caucasian, n</td><td>Age, yrs</td><td>Population</td><td>Study design</td><td>Enrollment states</td></tr><tr><td>Winkelmayer et al. 2011 [20]</td><td>1992–2006</td><td>90,217</td><td>121,698</td><td>>30*</td><td>Hemodialysis</td><td>Cohort</td><td>United States</td></tr><tr><td>Upshaw Jr. 2002 [21]</td><td>1996–1998</td><td>922</td><td>1,201</td><td>>20</td><td>Hospitalized patients</td><td>Cohort</td><td>Georgia</td></tr><tr><td>Shen et al. 2010 [22]</td><td>2008</td><td>40,293</td><td>191,860</td><td>>60</td><td>Older population</td><td>Cross-sectional</td><td>California</td></tr><tr><td>Smith et al. 2006 [23]</td><td>1993–2005</td><td>644</td><td>1,932</td><td>>25*</td><td>Post-CABG</td><td>Case control</td><td>Ohio</td></tr><tr><td>Lahiri et al. 2011 [24]</td><td>2004–2008</td><td>270</td><td>731</td><td>>25*</td><td>Post-CABG</td><td>Cohort</td><td>Michigan</td></tr></table>
dc1722707572d72d32fc93569fa908700983b34c28fc02e11e4b22cc4a46dc5d.png
complex
<table><tr><td>Characteristic</td><td>%</td><td>Crude <sup>1</sup></td><td>OR (95% CI)</td><td>Adj.<sup>2</sup></td><td>OR (95% CI)</td><td>Adj.<sup>3</sup></td><td>OR (95% CI)</td></tr><tr><td></td><td></td><td></td><td></td><td colspan="2">Model 1</td><td colspan="2">Model 2</td></tr><tr><td>Age-Race/ethnicity</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Interaction<sup>4</sup></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> &lt;60, Non-Black</td><td></td><td>1.00</td><td>(referent)</td><td>1.00</td><td>(referent)</td><td></td><td></td></tr><tr><td> &lt;60, NH Black</td><td></td><td>2.98</td><td>(1.77 - 4.96)</td><td>2.62</td><td>(1.50 - 4.52)</td><td></td><td></td></tr><tr><td> 60-64, Non-Black</td><td></td><td>2.01</td><td>(1.42 - 2.88)</td><td>1.95</td><td>(1.36 - 2.83)</td><td></td><td></td></tr><tr><td> 60-64, NH Black</td><td></td><td>2.80</td><td>(1.52 - 5.03)</td><td>2.53</td><td>(1.32 - 4.72)</td><td></td><td></td></tr><tr><td> 65-74, Non-Black</td><td></td><td>7.20</td><td>(5.38 - 9.79)</td><td>7.55</td><td>(5.57 - 10.40)</td><td></td><td></td></tr><tr><td> 65-74, NH Black</td><td></td><td>5.14</td><td>(3.24 - 8.18)</td><td>5.19</td><td>(3.15 - 8.59)</td><td></td><td></td></tr><tr><td> &gt;= 75, Non-Black</td><td></td><td>68.08</td><td>(41.57 - 116.45)</td><td>69.73</td><td>(41.94 - 120.93)</td><td></td><td></td></tr><tr><td> &gt;= 75, NH Black</td><td></td><td>41.09</td><td>(13.58 - 178.13)</td><td>43.31</td><td>(13.28 - 196.39)</td><td></td><td></td></tr><tr><td>Age at diagnosis</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> &lt;60</td><td>17.20</td><td>1.00</td><td>(referent)</td><td></td><td></td><td>1.00</td><td>(referent)</td></tr><tr><td> 60-64</td><td>25.54</td><td>1.65</td><td>(1.22 - 2.25)</td><td></td><td></td><td>1.63</td><td>(1.18 - 2.26)</td></tr><tr><td> 65-69</td><td>39.76</td><td>3.18</td><td>(2.41 - 4.22)</td><td></td><td></td><td>3.37</td><td>(2.52 - 4.54)</td></tr><tr><td> 70-74</td><td>69.25</td><td>10.84</td><td>(8.08 - 14.66)</td><td></td><td></td><td>12.22</td><td>(8.94 - 16.86)</td></tr><tr><td> &gt;= 75</td><td>91.32</td><td>50.63</td><td>(32.27 - 82.56)</td><td></td><td></td><td>54.47</td><td>(34.11 - 90.27)</td></tr><tr><td>Marital status</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> Married</td><td>42.30</td><td>1.00</td><td>(referent)</td><td>1.00</td><td>(referent)</td><td>1.00</td><td>(referent)</td></tr><tr><td> Not Married</td><td>49.18</td><td>1.32</td><td>(1.05 - 1.65)</td><td>1.44</td><td>(1.10 - 1.88)</td><td>1.51</td><td>(1.15 - 1.98)</td></tr><tr><td> Unknown</td><td>60.58</td><td>2.10</td><td>(1.41 - 3.16)</td><td>2.20</td><td>(1.36 - 3.58)</td><td>2.22</td><td>(1.36 - 3.65)</td></tr><tr><td>Registry</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> California</td><td>36.60</td><td>1.00</td><td>(referent)</td><td>1.00</td><td>(referent)</td><td>1.00</td><td>(referent)</td></tr><tr><td> Colorado</td><td>39.30</td><td>1.12</td><td>(0.83 - 1.52)</td><td>1.57</td><td>(1.10 - 2.25)</td><td>1.60</td><td>(1.11 - 2.31)</td></tr><tr><td> Illinois</td><td>46.46</td><td>1.50</td><td>(1.11 - 2.04)</td><td>1.57</td><td>(1.09 - 2.27)</td><td>1.71</td><td>(1.17 - 2.49)</td></tr><tr><td> Louisiana</td><td>38.36</td><td>1.08</td><td>(0.80 - 1.46)</td><td>1.06</td><td>(0.73 - 1.53)</td><td>1.07</td><td>(0.74 - 1.56)</td></tr><tr><td> New York</td><td>53.80</td><td>2.02</td><td>(1.49 - 2.75)</td><td>2.40</td><td>(1.66 - 3.49)</td><td>2.78</td><td>(1.91 - 4.06)</td></tr><tr><td> Rhode Island</td><td>49.39</td><td>1.69</td><td>(1.24 - 2.30)</td><td>2.00</td><td>(1.39 - 2.90)</td><td>1.98</td><td>(1.36 - 2.89)</td></tr><tr><td> South Carolina</td><td>47.66</td><td>1.58</td><td>(1.14 - 2.19)</td><td>2.12</td><td>(1.43 - 3.14)</td><td>2.35</td><td>(1.58 - 3.51)</td></tr><tr><td>DRE results</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> Normal</td><td>40.28</td><td>1.00</td><td>(referent)</td><td>1.00</td><td>(referent)</td><td>1.00</td><td>(referent)</td></tr><tr><td> Abnormal</td><td>50.67</td><td>1.52</td><td>(1.26 - 1.84)</td><td>1.19</td><td>(0.95 - 1.50)</td><td>1.17</td><td>(0.93 - 1.48)</td></tr><tr><td> Equivocal/unknown</td><td>41.33</td><td>1.05</td><td>(0.85 - 1.29)</td><td>0.78</td><td>(0.60 - 1.02)</td><td>0.77</td><td>(0.59 - 1.00)</td></tr><tr><td>PSA value</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> 0-4</td><td>39.52</td><td>1.00</td><td>(referent)</td><td>1.00</td><td>(referent)</td><td>1.00</td><td>(referent)</td></tr><tr><td> &gt;4-10</td><td>41.56</td><td>1.09</td><td>(0.81 - 1.47)</td><td>1.01</td><td>(0.71 - 1.44)</td><td>1.06</td><td>(0.74 - 1.53)</td></tr><tr><td> &gt;10-20</td><td>53.88</td><td>1.79</td><td>(1.28 - 2.50)</td><td>1.57</td><td>(1.06 - 2.34)</td><td>1.64</td><td>(1.09 - 2.46)</td></tr><tr><td> 20+</td><td>61.00</td><td>2.40</td><td>(1.61 - 3.58)</td><td>2.14</td><td>(1.34 - 3.45)</td><td>2.17</td><td>(1.35 - 3.52)</td></tr><tr><td> Unknown</td><td>29.91</td><td>0.65</td><td>(0.44 - 0.97)</td><td>0.45</td><td>(0.27 - 0.73)</td><td>0.46</td><td>(0.28 - 0.75)</td></tr><tr><td>Gleason score</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> 2-4</td><td>43.01</td><td>1.00</td><td>(referent)</td><td>1.00</td><td>(referent)</td><td>1.00</td><td>(referent)</td></tr><tr><td> 5-7</td><td>40.92</td><td>0.92</td><td>(0.68 - 1.24)</td><td>0.76</td><td>(0.54 - 1.09)</td><td>0.76</td><td>(0.53 - 1.09)</td></tr><tr><td> 8-10</td><td>61.05</td><td>2.08</td><td>(1.39 - 3.13)</td><td>1.53</td><td>(0.94 - 2.48)</td><td>1.59</td><td>(0.97 - 2.62)</td></tr><tr><td> Unknown</td><td>72.48</td><td>3.49</td><td>(2.12 - 5.86)</td><td>5.59</td><td>(3.09 - 10.34)</td><td>5.64</td><td>(3.08 - 10.52)</td></tr></table>
<table><tr><td>Characteristic</td><td>%</td><td>Crude 1</td><td>OR (95% CI)</td><td>Adj.2</td><td>OR (95% CI)</td><td>Adj.3</td><td>OR (95% CI)</td></tr><tr><td></td><td></td><td></td><td></td><td colspan="2">Model 1</td><td colspan="2">Model 2</td></tr><tr><td>Age-Race/ethnicity</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Interaction4</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td><60, Non-Black</td><td></td><td>1.00</td><td>(referent)</td><td>1.00</td><td>(referent)</td><td></td><td></td></tr><tr><td><60, NH Black</td><td></td><td>2.98</td><td>(1.77 - 4.96)</td><td>2.62</td><td>(1.50 - 4.52)</td><td></td><td></td></tr><tr><td>60-64, Non-Black</td><td></td><td>2.01</td><td>(1.42 - 2.88)</td><td>1.95</td><td>(1.36 - 2.83)</td><td></td><td></td></tr><tr><td>60-64, NH Black</td><td></td><td>2.80</td><td>(1.52 - 5.03)</td><td>2.53</td><td>(1.32 - 4.72)</td><td></td><td></td></tr><tr><td>65-74, Non-Black</td><td></td><td>7.20</td><td>(5.38 - 9.79)</td><td>7.55</td><td>(5.57 - 10.40)</td><td></td><td></td></tr><tr><td>65-74, NH Black</td><td></td><td>5.14</td><td>(3.24 - 8.18)</td><td>5.19</td><td>(3.15 - 8.59)</td><td></td><td></td></tr><tr><td>>= 75, Non-Black</td><td></td><td>68.08</td><td>(41.57 - 116.45)</td><td>69.73</td><td>(41.94 - 120.93)</td><td></td><td></td></tr><tr><td>>= 75, NH Black</td><td></td><td>41.09</td><td>(13.58 - 178.13)</td><td>43.31</td><td>(13.28 - 196.39)</td><td></td><td></td></tr><tr><td>Age at diagnosis</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td><60</td><td>17.20</td><td>1.00</td><td>(referent)</td><td></td><td></td><td>1.00</td><td>(referent)</td></tr><tr><td>60-64</td><td>25.54</td><td>1.65</td><td>(1.22 - 2.25)</td><td></td><td></td><td>1.63</td><td>(1.18 - 2.26)</td></tr><tr><td>65-69</td><td>39.76</td><td>3.18</td><td>(2.41 - 4.22)</td><td></td><td></td><td>3.37</td><td>(2.52 - 4.54)</td></tr><tr><td>70-74</td><td>69.25</td><td>10.84</td><td>(8.08 - 14.66)</td><td></td><td></td><td>12.22</td><td>(8.94 - 16.86)</td></tr><tr><td>>= 75</td><td>91.32</td><td>50.63</td><td>(32.27 - 82.56)</td><td></td><td></td><td>54.47</td><td>(34.11 - 90.27)</td></tr><tr><td>Marital status</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Married</td><td>42.30</td><td>1.00</td><td>(referent)</td><td>1.00</td><td>(referent)</td><td>1.00</td><td>(referent)</td></tr><tr><td>Not Married</td><td>49.18</td><td>1.32</td><td>(1.05 - 1.65)</td><td>1.44</td><td>(1.10 - 1.88)</td><td>1.51</td><td>(1.15 - 1.98)</td></tr><tr><td>Unknown</td><td>60.58</td><td>2.10</td><td>(1.41 - 3.16)</td><td>2.20</td><td>(1.36 - 3.58)</td><td>2.22</td><td>(1.36 - 3.65)</td></tr><tr><td>Registry</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>California</td><td>36.60</td><td>1.00</td><td>(referent)</td><td>1.00</td><td>(referent)</td><td>1.00</td><td>(referent)</td></tr><tr><td>Colorado</td><td>39.30</td><td>1.12</td><td>(0.83 - 1.52)</td><td>1.57</td><td>(1.10 - 2.25)</td><td>1.60</td><td>(1.11 - 2.31)</td></tr><tr><td>Illinois</td><td>46.46</td><td>1.50</td><td>(1.11 - 2.04)</td><td>1.57</td><td>(1.09 - 2.27)</td><td>1.71</td><td>(1.17 - 2.49)</td></tr><tr><td>Louisiana</td><td>38.36</td><td>1.08</td><td>(0.80 - 1.46)</td><td>1.06</td><td>(0.73 - 1.53)</td><td>1.07</td><td>(0.74 - 1.56)</td></tr><tr><td>New York</td><td>53.80</td><td>2.02</td><td>(1.49 - 2.75)</td><td>2.40</td><td>(1.66 - 3.49)</td><td>2.78</td><td>(1.91 - 4.06)</td></tr><tr><td>Rhode Island</td><td>49.39</td><td>1.69</td><td>(1.24 - 2.30)</td><td>2.00</td><td>(1.39 - 2.90)</td><td>1.98</td><td>(1.36 - 2.89)</td></tr><tr><td>South Carolina</td><td>47.66</td><td>1.58</td><td>(1.14 - 2.19)</td><td>2.12</td><td>(1.43 - 3.14)</td><td>2.35</td><td>(1.58 - 3.51)</td></tr><tr><td>DRE results</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Normal</td><td>40.28</td><td>1.00</td><td>(referent)</td><td>1.00</td><td>(referent)</td><td>1.00</td><td>(referent)</td></tr><tr><td>Abnormal</td><td>50.67</td><td>1.52</td><td>(1.26 - 1.84)</td><td>1.19</td><td>(0.95 - 1.50)</td><td>1.17</td><td>(0.93 - 1.48)</td></tr><tr><td>Equivocal/unknown</td><td>41.33</td><td>1.05</td><td>(0.85 - 1.29)</td><td>0.78</td><td>(0.60 - 1.02)</td><td>0.77</td><td>(0.59 - 1.00)</td></tr><tr><td>PSA value</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>0-4</td><td>39.52</td><td>1.00</td><td>(referent)</td><td>1.00</td><td>(referent)</td><td>1.00</td><td>(referent)</td></tr><tr><td>>4-10</td><td>41.56</td><td>1.09</td><td>(0.81 - 1.47)</td><td>1.01</td><td>(0.71 - 1.44)</td><td>1.06</td><td>(0.74 - 1.53)</td></tr><tr><td>>10-20</td><td>53.88</td><td>1.79</td><td>(1.28 - 2.50)</td><td>1.57</td><td>(1.06 - 2.34)</td><td>1.64</td><td>(1.09 - 2.46)</td></tr><tr><td>20+</td><td>61.00</td><td>2.40</td><td>(1.61 - 3.58)</td><td>2.14</td><td>(1.34 - 3.45)</td><td>2.17</td><td>(1.35 - 3.52)</td></tr><tr><td>Unknown</td><td>29.91</td><td>0.65</td><td>(0.44 - 0.97)</td><td>0.45</td><td>(0.27 - 0.73)</td><td>0.46</td><td>(0.28 - 0.75)</td></tr><tr><td>G</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr></table>
<table><tr><td>leason score</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>2-4</td><td>43.01</td><td>1.00</td><td>(referent)</td><td>1.00</td><td>(referent)</td><td>1.00</td><td>(referent)</td></tr><tr><td>5-7</td><td>40.92</td><td>0.92</td><td>(0.68 - 1.24)</td><td>0.76</td><td>(0.54 - 1.09)</td><td>0.76</td><td>(0.53 - 1.09)</td></tr><tr><td>8-10</td><td>61.05</td><td>2.08</td><td>(1.39 - 3.13)</td><td>1.53</td><td>(0.94 - 2.48)</td><td>1.59</td><td>(0.97 - 2.62)</td></tr><tr><td>Unknown</td><td>72.48</td><td>3.49</td><td>(2.12 - 5.86)</td><td>5.59</td><td>(3.09 - 10.34)</td><td>5.64</td><td>(3.08 - 10.52)</td></tr></table>
1b952e2df871cc07fae0d10a4b25ceda75de29a1c6c6912d7e586fef540b54c6.png
simple
<table><tr><td>Indicators</td><td>Prevalence per 10,000 (n/N)*</td><td>95 % CI</td></tr><tr><td>Prevalence of congenital defects</td><td>52.0 (142/27201)</td><td>44.0&#8211;61.0</td></tr><tr><td>Prevalence of selected NTDs only</td><td>4.0 (11/27201)</td><td>2.0&#8211;7.0</td></tr><tr><td>Prevalence of other congenital defects except NTDs</td><td>48.0 (131/27201)</td><td>40.0&#8211;57.0</td></tr><tr><td>Prevalence of congenital defects in Mountain</td><td>16.0 (5/3079)</td><td>7.0&#8211;38.0</td></tr><tr><td>Prevalence of congenital defects in Hill</td><td>56.0 (85/15156)</td><td>45.0&#8211;69.0</td></tr><tr><td>Prevalence of congenital defects in Terai</td><td>58.0 (52/8966)</td><td>44.0&#8211;76.0</td></tr></table>
<table><tr><td>Indicators</td><td>Prevalence per 10,000 (n/N)*</td><td>95 % CI</td></tr><tr><td>Prevalence of congenita</td><td>52.0 (</td><td>44.0–61</td></tr></table>
<table><tr><td>l defects</td><td>142/27201)</td><td>.0</td></tr><tr><td>Prevalence of selected NTDs only</td><td>4.0 (11/27201)</td><td>2.0–7.0</td></tr><tr><td>Prevalence of other congenital defects except NTDs</td><td>48.0 (131/27201)</td><td>40.0–57.0</td></tr><tr><td>Prevalence of congenital defects in Mountain</td><td>16.0 (5/3079)</td><td>7.0–38.0</td></tr><tr><td>Prevalence of congenital defects in Hill</td><td>56.0 (85/15156)</td><td>45.0–69.0</td></tr><tr><td>Prevalence of congenital defects in Terai</td><td>58.0 (52/8966)</td><td>44.0–76.0</td></tr></table>
c05ae63e7893afc6da824460d15616d250d722bab227a55740d6a9273ec5ab03.png
simple
<table><tr><td>Variable</td><td>Frequency</td><td>%</td></tr><tr><td><i>Age (mean = 36.8 &#177; 14.0 yrs)</i></td><td> </td><td> </td></tr><tr><td>&lt; 50 years</td><td>554</td><td>80</td></tr><tr><td>&#8805; 50 years</td><td>139</td><td>20</td></tr><tr><td><i>Gender</i></td><td> </td><td> </td></tr><tr><td>Male</td><td>374</td><td>54</td></tr><tr><td>Female</td><td>319</td><td>46</td></tr><tr><td><i>Religion</i></td><td> </td><td> </td></tr><tr><td>Christian</td><td>554</td><td>80</td></tr><tr><td>Moslem</td><td>111</td><td>16</td></tr><tr><td>Traditional religion</td><td>21</td><td>3</td></tr><tr><td>Other</td><td>7</td><td>1</td></tr><tr><td><i>Marital status</i></td><td> </td><td> </td></tr><tr><td>Married</td><td>267</td><td>38</td></tr><tr><td>Single</td><td>281</td><td>41</td></tr><tr><td>Widowed</td><td>68</td><td>10</td></tr><tr><td>Separated</td><td>50</td><td>7</td></tr><tr><td>Divorced</td><td>27</td><td>4</td></tr><tr><td><i>Highest education attained</i></td><td> </td><td> </td></tr><tr><td>Illiterate</td><td>97</td><td>14</td></tr><tr><td>Primary</td><td>104</td><td>15</td></tr><tr><td>Secondary</td><td>360</td><td>52</td></tr><tr><td>Tertiary</td><td>132</td><td>19</td></tr><tr><td><i>Monthly income (Cedis)</i></td><td> </td><td> </td></tr><tr><td>&lt; 100</td><td>180</td><td>26</td></tr><tr><td>100-999</td><td>270</td><td>39</td></tr><tr><td>1000-1999</td><td>21</td><td>3</td></tr><tr><td>2000-2999</td><td>14</td><td>2</td></tr><tr><td>&#8805; 3000</td><td>14</td><td>2</td></tr><tr><td>Unemployed</td><td>194</td><td>28</td></tr><tr><td><i>Stroke risk factors</i></td><td> </td><td> </td></tr><tr><td>Alcohol intake</td><td>118</td><td>17</td></tr><tr><td>Hypertension</td><td>76</td><td>11</td></tr><tr><td>Smoking</td><td>47</td><td>7</td></tr><tr><td>Previous stroke</td><td>43</td><td>6</td></tr><tr><td>High cholesterol</td><td>25</td><td>4</td></tr><tr><td>Heart disease</td><td>19</td><td>3</td></tr><tr><td>Diabetes</td><td>17</td><td>2</td></tr><tr><td>At least one stroke risk factor</td><td>274</td><td>40</td></tr></table>
<table><tr><td>Variable</td><td>Frequency</td><td>%</td></tr><tr><td>Age (mean = 36.8 ± 14.0 yrs)</td><td></td><td></td></tr><tr><td>< 50 years</td><td>554</td><td>80</td></tr><tr><td>≥ 50 years</td><td>139</td><td>20</td></tr><tr><td>Gender</td><td></td><td></td></tr></table>
<table><tr><td>Male</td><td>374</td><td>54</td></tr><tr><td>Female</td><td>319</td><td>46</td></tr><tr><td>Religion</td><td></td><td></td></tr><tr><td>Christian</td><td>554</td><td>80</td></tr><tr><td>Moslem</td><td>111</td><td>16</td></tr><tr><td>Traditional religion</td><td>21</td><td>3</td></tr><tr><td>Other</td><td>7</td><td>1</td></tr><tr><td>Marital status</td><td></td><td></td></tr><tr><td>Married</td><td>267</td><td>38</td></tr><tr><td>Single</td><td>281</td><td>41</td></tr><tr><td>Widowed</td><td>68</td><td>10</td></tr><tr><td>Separated</td><td>50</td><td>7</td></tr><tr><td>Divorced</td><td>27</td><td>4</td></tr><tr><td>Highest education attained</td><td></td><td></td></tr><tr><td>Illiterate</td><td>97</td><td>14</td></tr><tr><td>Primary</td><td>104</td><td>15</td></tr><tr><td>Secondary</td><td>360</td><td>52</td></tr><tr><td>Tertiary</td><td>132</td><td>19</td></tr><tr><td>Monthly income (Cedis)</td><td></td><td></td></tr><tr><td>< 100</td><td>180</td><td>26</td></tr><tr><td>100-999</td><td>270</td><td>39</td></tr><tr><td>1000-1999</td><td>21</td><td>3</td></tr><tr><td>2000-2999</td><td>14</td><td>2</td></tr><tr><td>≥ 3000</td><td>14</td><td>2</td></tr><tr><td>Unemployed</td><td>194</td><td>28</td></tr><tr><td>Stroke risk factors</td><td></td><td></td></tr><tr><td>Alcohol intake</td><td>118</td><td>17</td></tr><tr><td>Hypertension</td><td>76</td><td>11</td></tr><tr><td>Smoking</td><td>47</td><td>7</td></tr><tr><td>Previous stroke</td><td>43</td><td>6</td></tr><tr><td>High cholesterol</td><td>25</td><td>4</td></tr><tr><td>Heart disease</td><td>19</td><td>3</td></tr><tr><td>Diabetes</td><td>17</td><td>2</td></tr><tr><td>At least one stroke risk factor</td><td>274</td><td>40</td></tr></table>
74b887676d2a3a2719293f1f7896ea9177a66a80cd417d69f4b377e700e074c5.png
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<table><tr><td>Method</td><td>Detection range</td><td>Reference</td></tr><tr><td>Colorimetric</td><td>0.05&#8211;50 ng/mL</td><td>Luan et al., 2015</td></tr><tr><td>Surface plasmon resonance</td><td>0&#8211;10 ng/mL</td><td>Zhu et al., 2015</td></tr><tr><td>Colorimetric</td><td>0.5&#8211;100 ng/mL</td><td>Wang et al., 2016a</td></tr><tr><td>Colorimetric</td><td>0.0316&#8211;316 ng/mL</td><td>Our work</td></tr></table>
<table><tr><td>Method</td><td>Detection range</td><td>Reference</td></tr><tr><td>Colorimetric</td><td>0.05–50 ng/mL</td><td>Luan et al., 2015</td></tr><tr><td>Surface plasmon resonance</td><td>0–10 ng/mL</td><td>Zhu et al., 2015</td></tr></table>
<table><tr><td>Colorimetric</td><td>0.5–100 ng/mL</td><td>Wang et al., 2016a</td></tr><tr><td>Colorimetric</td><td>0.0316–316 ng/mL</td><td>Our work</td></tr></table>
82cd874052d087c00f52efa4e4aec2f9205c4f0c561ac8430902f30f12492ca1.png
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<table><tr><td>Variable</td><td>De Hoogte(<i>n</i> = 90)</td><td>Corpus-Noord(<i>n</i> = 133)</td><td><i>F</i></td><td><i>p</i></td><td><i>&#951;<sub>p</sub></i><sup>2</sup></td></tr><tr><td>Neighborhood Satisfaction (1&#8211;5)</td><td>3.39 (0.07)</td><td>3.88 (0.07)</td><td>26.12</td><td>&lt;0.001</td><td>0.11</td></tr><tr><td>Well-Being (Happiness; 0&#8211;10)</td><td>7.24 (0.14)</td><td>7.34 (0.11)</td><td>0.34</td><td>0.563</td><td>0.00</td></tr><tr><td>Green Space Quality (1&#8211;5; average score)</td><td>3.21 (0.07)</td><td>3.61 (0.06)</td><td>20.04</td><td>&lt;0.001</td><td>0.08</td></tr><tr><td><i>Green spaces in my neighborhood</i></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>1. contain enough recreational facilities (e.g., play equipment, hard court, grass pitches for football).</td><td>3.10 (0.11)</td><td>3.39 (0.09)</td><td>4.13</td><td>0.043</td><td>0.02</td></tr><tr><td>2. provide amenities for sitting, picnic table, litter bins, signs and lighting in the night.</td><td>2.74 (0.11)</td><td>3.37 (0.09)</td><td>18.16</td><td>&lt;0.001</td><td>0.08</td></tr><tr><td>3. have good natural features such as grass, trees and flower beds.</td><td>3.37 (0.09)</td><td>3.87 (0.07)</td><td>17.71</td><td>&lt;0.001</td><td>0.08</td></tr><tr><td>4. are absent of incivilities (e.g., general litter, graffiti, dog mess, evidence of alcohol, drug use, broken glass and noise).</td><td>2.95 (0.11)</td><td>3.40 (0.09)</td><td>10.15</td><td>0.002</td><td>0.04</td></tr><tr><td>5. are easily accessed, there are many access points and enough walking paths, and roads around are not busy.</td><td>3.64 (0.08)</td><td>3.91 (0.06)</td><td>7.36</td><td>0.007</td><td>0.03</td></tr><tr><td>6. are well maintained.</td><td>3.47 (0.11)</td><td>3.73 (0.09)</td><td>3.46</td><td>0.06</td><td>0.02</td></tr><tr><td>Beneficial Affordances of Green Space (1&#8211;5; average score)</td><td>4.00 (0.08)</td><td>3.98 (0.06)</td><td>0.05</td><td>0.824</td><td>0.00</td></tr><tr><td><i>Green spaces in my neighborhood</i></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>1. promote the quality of life.</td><td>4.12 (0.08)</td><td>4.16 (0.07)</td><td>0.08</td><td>0.779</td><td>0.00</td></tr><tr><td>2. promote health.</td><td>4.12 (0.08)</td><td>4.06 (0.07)</td><td>0.37</td><td>0.544</td><td>0.00</td></tr><tr><td>3. promote recreational use.</td><td>3.90 (0.10)</td><td>4.01 (0.08)</td><td>0.68</td><td>0.411</td><td>0.00</td></tr><tr><td>4. promote social interaction.</td><td>3.86 (0.10)</td><td>3.69 (0.08)</td><td>1.55</td><td>0.214</td><td>0.01</td></tr></table>
<table><tr><td>Variable</td><td>De Hoogte(n = 90)</td><td>Corpus-Noord(n = 133)</td><td>F</td><td>p</td><td>ηp2</td></tr><tr><td>Neighborhood Satisfaction (1–5)</td><td>3.39 (0.07)</td><td>3.88 (0.07)</td><td>26.12</td><td><0.001</td><td>0.11</td></tr><tr><td>Well-Being (Happiness; 0–10)</td><td>7.24 (0.14)</td><td>7.34 (0.11)</td><td>0.34</td><td>0.563</td><td>0.00</td></tr><tr><td>Green Space Quality (1–5; average score)</td><td>3.21 (0.07)</td><td>3.61 (0.06)</td><td>20.04</td><td><0.001</td><td>0.08</td></tr><tr><td>Green spaces in my neighborhood</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>1. contain enough recreational facilities (e.g., play equipment, hard court, grass pitches for football).</td><td>3.10 (0.11)</td><td>3.39 (0.09)</td><td>4.13</td><td>0.043</td><td>0.02</td></tr><tr><td>2. provide amenities for sitting, picnic table, litter bins, signs and lighting in the night.</td><td>2.74 (0.11)</td><td>3.37 (0.09)</td><td>18.16</td><td><0.001</td><td>0.08</td></tr><tr><td>3. have good natural features such as grass, trees and flower beds.</td><td>3.37 (0.09)</td><td>3.87 (0.07)</td><td>17.71</td><td><0.001</td><td>0.08</td></tr></table>
<table><tr><td>4. are absent of incivilities (e.g., general litter, graffiti, dog mess, evidence of alcohol, drug use, broken glass and noise).</td><td>2.95 (0.11)</td><td>3.40 (0.09)</td><td>10.15</td><td>0.002</td><td>0.04</td></tr><tr><td>5. are easily accessed, there are many access points and enough walking paths, and roads around are not busy.</td><td>3.64 (0.08)</td><td>3.91 (0.06)</td><td>7.36</td><td>0.007</td><td>0.03</td></tr><tr><td>6. are well maintained.</td><td>3.47 (0.11)</td><td>3.73 (0.09)</td><td>3.46</td><td>0.06</td><td>0.02</td></tr><tr><td>Beneficial Affordances of Green Space (1–5; average score)</td><td>4.00 (0.08)</td><td>3.98 (0.06)</td><td>0.05</td><td>0.824</td><td>0.00</td></tr><tr><td>Green spaces in my neighborhood</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>1. promote the quality of life.</td><td>4.12 (0.08)</td><td>4.16 (0.07)</td><td>0.08</td><td>0.779</td><td>0.00</td></tr><tr><td>2. promote health.</td><td>4.12 (0.08)</td><td>4.06 (0.07)</td><td>0.37</td><td>0.544</td><td>0.00</td></tr><tr><td>3. promote recreational use.</td><td>3.90 (0.10)</td><td>4.01 (0.08)</td><td>0.68</td><td>0.411</td><td>0.00</td></tr><tr><td>4. promote social interaction.</td><td>3.86 (0.10)</td><td>3.69 (0.08)</td><td>1.55</td><td>0.214</td><td>0.01</td></tr></table>
df83d613c0df6ddc93edfdf320771d2aef072f335932c178fb8a9cc8cf8f184b.png
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<table><tr><td>TLD placement</td><td colspan="2">Cumulative mSv</td><td colspan="2">mSv per screw</td><td>% Reduction</td></tr><tr><td></td><td>Robot-Guided (154 screws)</td><td>Fluoro-Guided (140 screws)</td><td>Robot-guided</td><td>Fluoro-guided</td><td></td></tr><tr><td>Outside of thyroid protector</td><td>1.24</td><td>3.15</td><td>0.0082</td><td>0.0225</td><td>63.7%</td></tr><tr><td>Inside of thyroid protector</td><td>0.91</td><td>1.95</td><td>0.0060</td><td>0.0139</td><td>56.9%</td></tr><tr><td>Outside of trunk protector</td><td>1.37</td><td>3.35</td><td>0.0090</td><td>0.0239</td><td>62.3%</td></tr><tr><td>Inside of trunk protector</td><td>0.84</td><td>1.84</td><td>0.0055</td><td>0.0131</td><td>57.8%</td></tr><tr><td>Eye dosimeter</td><td>0.71</td><td>2.31</td><td>0.0047</td><td>0.0165</td><td>71.6%</td></tr></table>
<table><tr><td>TLD placement</td><td>Cumulative mSv</td></tr><tr><td></td><td>Robot-Guided (154 screws)</td></tr><tr><td>Outside of thyroid protector</td><td>1.24</td></tr><tr><td>Inside of thyroid protector</td><td>0.91</td></tr><tr><td>Outside of trunk protector</td><td>1.37</td></tr><tr><td>Inside of trunk protector</td><td>0.84</td></tr><tr><td>Eye dosimeter</td><td>0.71</td></tr></table>
<table><tr><td>Cumulative mSv</td><td colspan="2">mSv per screw</td><td>% Reduction</td></tr><tr><td>Fluoro-Guided (140 screws)</td><td>Robot-guided</td><td>Fluoro-guided</td><td></td></tr><tr><td>3.15</td><td>0.0082</td><td>0.0225</td><td>63.7%</td></tr><tr><td>1.95</td><td>0.0060</td><td>0.0139</td><td>56.9%</td></tr><tr><td>3.35</td><td>0.0090</td><td>0.0239</td><td>62.3%</td></tr><tr><td>1.84</td><td>0.0055</td><td>0.0131</td><td>57.8%</td></tr><tr><td>2.31</td><td>0.0047</td><td>0.0165</td><td>71.6%</td></tr></table>
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<table><tr><td colspan="2">Identification criteria</td></tr><tr><td>Cardiovascular dysfunction</td><td>&#8226; Shock</td></tr><tr><td></td><td>&#8226; Use of continuous vasoactive drugs</td></tr><tr><td></td><td>&#8226; Cardiac arrest</td></tr><tr><td></td><td>&#8226; Cardio-pulmonary resuscitation</td></tr><tr><td></td><td>&#8226; Severe hypoperfusion (lactate &gt; 5 mmol/L or &gt; 45 mg/dL)</td></tr><tr><td></td><td>&#8226; Severe acidosis (pH &lt; 7.1)</td></tr><tr><td>Respiratory dysfunction</td><td>&#8226; Acute cyanosis</td></tr><tr><td></td><td>&#8226; Gasping</td></tr><tr><td></td><td>&#8226; Severe tachypnea (respiratory rate &gt; 40 bpm)</td></tr><tr><td></td><td>&#8226; Severe bradypnea (respiratory rate &lt; 6 bpm)</td></tr><tr><td></td><td>&#8226; Severe hypoxemia (PAO2/FiO2 &lt; 200 or O2 saturation &lt; 90 % for &#8805;60 min)</td></tr><tr><td></td><td>&#8226; Intubation and ventilation not related to anesthesia</td></tr><tr><td>Renal dysfunction</td><td>&#8226; Oliguria non responsive to fluids/diuretics</td></tr><tr><td></td><td>&#8226; Dialysis for acute renal failure</td></tr><tr><td></td><td>&#8226; Severe acute azotemia (creatinine &#8805; 300 umol/ml or &#8805; 3.5 mg/dL)</td></tr><tr><td>Coagulation/hematologic dysfunction</td><td>&#8226; Failure to form clots</td></tr><tr><td></td><td>&#8226; Massive transfusion of blood or red cells (&#8805;5 units)</td></tr><tr><td></td><td>&#8226; Severe acute thrombocytopenia (&lt;50,000 platelets/ml)</td></tr><tr><td>Hepatic dysfunction</td><td>&#8226; Jaundice in the presence of pre-eclampsia</td></tr><tr><td></td><td>&#8226; Severe acute hyperbilirubinemia (bilirubin &gt; 100 umol/L or &gt; 6.0 mg/dL)</td></tr><tr><td>Neurologic dysfunction</td><td>&#8226; Prolonged unconsciousness (lasting &#8805; 12 hours)/coma (including metabolic coma)</td></tr><tr><td></td><td>&#8226; Stroke</td></tr><tr><td></td><td>&#8226; Status epilepticus/uncontrollable fits</td></tr><tr><td></td><td>&#8226; Total paralysis</td></tr><tr><td>Uterine dysfunction</td><td>&#8226; Hemorrhage or infection leading to hysterectomy</td></tr></table>
<table><tr><td colspan="2">Identification criteria</td></tr><tr><td>Cardiovascular dysfunction</td><td>• Shock</td></tr><tr><td></td><td>• Use of continuous vasoactive drugs</td></tr><tr><td></td><td>• Cardiac ar</td></tr></table>
<table><tr><td colspan="2">Identification criteria</td></tr><tr><td></td><td>rest</td></tr><tr><td></td><td>• Cardio-pulmonary resuscitation</td></tr><tr><td></td><td>• Severe hypoperfusion (lactate > 5 mmol/L or > 45 mg/dL)</td></tr><tr><td></td><td>• Severe acidosis (pH < 7.1)</td></tr><tr><td>Respiratory dysfunction</td><td>• Acute cyanosis</td></tr><tr><td></td><td>• Gasping</td></tr><tr><td></td><td>• Severe tachypnea (respiratory rate > 40 bpm)</td></tr><tr><td></td><td>• Severe bradypnea (respiratory rate < 6 bpm)</td></tr><tr><td></td><td>• Severe hypoxemia (PAO2/FiO2 < 200 or O2 saturation < 90 % for ≥60 min)</td></tr><tr><td></td><td>• Intubation and ventilation not related to anesthesia</td></tr><tr><td>Renal dysfunction</td><td>• Oliguria non responsive to fluids/diuretics</td></tr><tr><td></td><td>• Dialysis for acute renal failure</td></tr><tr><td></td><td>• Severe acute azotemia (creatinine ≥ 300 umol/ml or ≥ 3.5 mg/dL)</td></tr><tr><td>Coagulation/hematologic dysfunction</td><td>• Failure to form clots</td></tr><tr><td></td><td>• Massive transfusion of blood or red cells (≥5 units)</td></tr><tr><td></td><td>• Severe acute thrombocytopenia (<50,000 platelets/ml)</td></tr><tr><td>Hepatic dysfunction</td><td>• Jaundice in the presence of pre-eclampsia</td></tr><tr><td></td><td>• Severe acute hyperbilirubinemia (bilirubin > 100 umol/L or > 6.0 mg/dL)</td></tr><tr><td>Neurologic dysfunction</td><td>• Prolonged unconsciousness (lasting ≥ 12 hours)/coma (including metabolic coma)</td></tr><tr><td></td><td>• Stroke</td></tr><tr><td></td><td>• Status epilepticus/uncontrollable fits</td></tr><tr><td></td><td>• Total paralysis</td></tr><tr><td>Uterine dysfunction</td><td>• Hemorrhage or infection leading to hysterectomy</td></tr></table>
6f0ecaffba7b5bd2ec4e8b9419b2c06c628812633fa1c398a2ef4892d82aaab8.png
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<table><tr><td></td><td>Duration</td><td>ARBs</td><td>ACEi</td><td>CCBs</td><td>BBs</td><td>Diuretics</td></tr><tr><td>Bloom [15]</td><td>12</td><td>64%</td><td>58%***</td><td>50%</td><td>43%</td><td>38%</td></tr><tr><td>Conlin [18]</td><td>48</td><td>50.9%</td><td>46.5%</td><td>40.7%**</td><td>34.7%**</td><td>16.4%**</td></tr><tr><td>Hasford [36]</td><td>12</td><td>51.3%</td><td>42.0%</td><td>43.6%</td><td>49.7%</td><td>34.4%</td></tr><tr><td>Degli-Esposti [23]</td><td>12</td><td>41.7%</td><td>32.2%</td><td>26.7%</td><td>36.9%</td><td>25.9%</td></tr><tr><td>Erkens [37]</td><td>12</td><td>62.0%</td><td>59.7%</td><td>34.7%</td><td>35.0%</td><td>33.0%</td></tr><tr><td>Veronesi [19]</td><td>24</td><td>68.5%</td><td>64.5%</td><td>51.6%**</td><td>44.8%**</td><td>34.4%*</td></tr><tr><td>Hasford [17]</td><td>12</td><td>26.4%</td><td>28.2%</td><td>25.9%</td><td>25.8%</td><td>21.9%</td></tr><tr><td>Patel [16]</td><td>12</td><td>51.9%</td><td>48.0%</td><td>38.3%</td><td>40.3%</td><td>29.9%</td></tr></table>
<table><tr><td></td><td>Duration</td><td>ARBs</td><td>ACEi</td><td>CCBs</td><td>BBs</td><td>Diuretics</td></tr><tr><td>Bloom [15]</td><td>12</td><td>64%</td><td>58%***</td><td>50%</td><td>43%</td><td>38%</td></tr></table>
<table><tr><td>Conlin [18]</td><td>48</td><td>50.9%</td><td>46.5%</td><td>40.7%**</td><td>34.7%**</td><td>16.4%**</td></tr><tr><td>Hasford [36]</td><td>12</td><td>51.3%</td><td>42.0%</td><td>43.6%</td><td>49.7%</td><td>34.4%</td></tr><tr><td>Degli-Esposti [23]</td><td>12</td><td>41.7%</td><td>32.2%</td><td>26.7%</td><td>36.9%</td><td>25.9%</td></tr><tr><td>Erkens [37]</td><td>12</td><td>62.0%</td><td>59.7%</td><td>34.7%</td><td>35.0%</td><td>33.0%</td></tr><tr><td>Veronesi [19]</td><td>24</td><td>68.5%</td><td>64.5%</td><td>51.6%**</td><td>44.8%**</td><td>34.4%*</td></tr><tr><td>Hasford [17]</td><td>12</td><td>26.4%</td><td>28.2%</td><td>25.9%</td><td>25.8%</td><td>21.9%</td></tr><tr><td>Patel [16]</td><td>12</td><td>51.9%</td><td>48.0%</td><td>38.3%</td><td>40.3%</td><td>29.9%</td></tr></table>
f6bd3352c3201bde2ba0c8ee71ea7d7d6e478a85e7800ab62cd4db64ce48f76a.png
complex
<table><tr><td>Main Geographic Region</td><td>Populations (ID)</td><td>Individuals</td><td colspan="2">HWE</td><td colspan="2">(%) allele frequencies LCE3 C_LCE3B-del</td><td colspan="3">SNP genotype frequencies (%)</td><td>LD</td></tr><tr><td> </td><td> </td><td> </td><td>x<sup>2</sup></td><td>p-value</td><td>+</td><td>&#8722;</td><td>AA</td><td>AG</td><td>GG</td><td>r<sup>2</sup></td></tr><tr><td>Sub-Saharan Africans</td><td>Pygmies* (PYG)</td><td>44</td><td>0.93</td><td>0.33</td><td>64.77</td><td>35.23</td><td>0</td><td>13.64</td><td>86.36</td><td>0.013</td></tr><tr><td> </td><td>Mandenka (MAN)</td><td>17</td><td>0.78</td><td>0.56</td><td>58.82</td><td>41.18</td><td>4.55</td><td>22.73</td><td>72.73</td><td>0.121</td></tr><tr><td> </td><td>Yoruba (YRI)</td><td>22</td><td>2.18</td><td>0.14</td><td>65.91</td><td>34.09</td><td>0</td><td>28.57</td><td>71.43</td><td>0.089</td></tr><tr><td> </td><td>Bantu (BAN)</td><td>18</td><td>2.66</td><td>0.10</td><td>72.22</td><td>27.78</td><td>0</td><td>50.00</td><td>50.00</td><td>0</td></tr><tr><td>North-African/Middle East</td><td>Mozabite* (ALG)</td><td>26</td><td>0.04</td><td>0.84</td><td>32.69</td><td>67.31</td><td>0</td><td>21.43</td><td>78.57</td><td>0.256</td></tr><tr><td> </td><td>Bedouin* (BED)</td><td>36</td><td>0.47</td><td>0.49</td><td>47.22</td><td>52.78</td><td>14.63</td><td>53.66</td><td>31.71</td><td>0.772</td></tr><tr><td> </td><td>Druze* (DRU)</td><td>37</td><td>1.87</td><td>0.17</td><td>36.49</td><td>63.51</td><td>9.09</td><td>56.82</td><td>34.09</td><td>1</td></tr><tr><td> </td><td>Palestinian (PAL)</td><td>40</td><td>0.44</td><td>0.50</td><td>31.25</td><td>68.75</td><td>4.44</td><td>44.44</td><td>51.11</td><td>0.936</td></tr><tr><td>European</td><td>French (FRA)</td><td>27</td><td>1.47</td><td>0.23</td><td>40.74</td><td>59.26</td><td>16.67</td><td>41.67</td><td>41.67</td><td>1</td></tr><tr><td> </td><td>French Basque* (BASQ)</td><td>21</td><td>1.70</td><td>0.19</td><td>40.48</td><td>59.52</td><td>9.09</td><td>54.55</td><td>36.36</td><td>0.91</td></tr><tr><td> </td><td>Sardinian* (SARD)</td><td>24</td><td>0</td><td>0.97</td><td>29.17</td><td>70.83</td><td>13.04</td><td>47.83</td><td>39.13</td><td>1</td></tr><tr><td> </td><td>Italian (ITL)</td><td>17</td><td>0.28</td><td>0.60</td><td>31.76</td><td>38.24</td><td>35.00</td><td>40.00</td><td>25.00</td><td>1</td></tr><tr><td> </td><td>Orcadian* (ORC)</td><td>16</td><td>2.80</td><td>0.09</td><td>31.25</td><td>68.75</td><td>23.08</td><td>23.08</td><td>53.85</td><td>1</td></tr><tr><td> </td><td>Russian (RUS)</td><td>23</td><td>0.18</td><td>0.68</td><td>39.13</td><td>60.87</td><td>14.29</td><td>42.86</td><td>42.86</td><td>0.897</td></tr><tr><td>Central-South Asians</td><td>Brahui (BRA)</td><td>22</td><td>0.61</td><td>0.44</td><td>43.18</td><td>56.82</td><td>21.74</td><td>43.48</td><td>34.78</td><td>1</td></tr><tr><td> </td><td>Balochi (BAL)</td><td>18</td><td>0.21</td><td>0.65</td><td>27.78</td><td>72.22</td><td>5.00</td><td>40.00</td><td>55.00</td><td>0.852</td></tr><tr><td> </td><td>Makrani (MAK)</td><td>24</td><td>0.67</td><td>0.41</td><td>50.00</td><td>50.00</td><td>23.81</td><td>42.86</td><td>33.33</td><td>0.55</td></tr><tr><td> </td><td>Sindhi (SIN)</td><td>21</td><td>1.71</td><td>0.19</td><td>33.33</td><td>66.67</td><td>0</td><td>50.00</td><td>50.00</td><td>0.905</td></tr><tr><td> </td><td>Kalash* (KAL)</td><td>24</td><td>1.53</td><td>0.22</td><td>47.92</td><td>52.08</td><td>16.67</td><td>55.56</td><td>27.78</td><td>0.861</td></tr><tr><td> </td><td>Burusho (BUR)</td><td>23</td><td>3.19</td><td>0.07</td><td>41.30</td><td>58.70</td><td>27.27</td><td>31.82</td><td>40.91</td><td>1</td></tr><tr><td> </td><td>Hazara ( HAZ)</td><td>17</td><td>1.14</td><td>0.29</td><td>79.41</td><td>20.59</td><td>43.75</td><td>56.25</td><td>0</td><td>0.904</td></tr><tr><td>Eastern Asians</td><td>Han (CHB)</td><td>34</td><td>0</td><td>0.98</td><td>38.24</td><td>61.76</td><td>0</td><td>52.17</td><td>47.83</td><td>0.468</td></tr><tr><td> </td><td>Japanese (JPN)</td><td>26</td><td>2.45</td><td>0.12</td><td>48.08</td><td>51.92</td><td>50.00</td><td>37.93</td><td>37.93</td><td>0.837</td></tr><tr><td> </td><td>Yaut* (YAK)</td><td>11</td><td>0.55</td><td>0.46</td><td>77.27</td><td>22.73</td><td>50.00</td><td>31.82</td><td>18.18</td><td>1</td></tr><tr><td> </td><td>NEA</td><td>34</td><td>0.54</td><td>0.46</td><td>45.59</td><td>54.41</td><td>20.59</td><td>52.94</td><td>26.47</td><td>0.852</td></tr><tr><td> </td><td>SEA</td><td>36</td><td>0.73</td><td>0.40</td><td>29.17</td><td>70.83</td><td>5.88</td><td>50.00</td><td>44.12</td><td>0.537</td></tr><tr><td>Oceania</td><td>Papuan-Melasian (OCE)</td><td>35</td><td>2.31</td><td>0.13</td><td>50.00</td><td>50.00</td><td>26.47</td><td>41.18</td><td>32.35</td><td>0.935</td></tr><tr><td>Americans</td><td>PIMA</td><td>22</td><td>0.51</td><td>0.48</td><td>25.00</td><td>75.00</td><td>9.09</td><td>36.36</td><td>54.55</td><td>0.804</td></tr><tr><td> </td><td>MAYA</td><td>21</td><td>0.94</td><td>0.33</td><td>38.10</td><td>61.90</td><td>7.14</td><td>57.14</td><td>35.71</td><td>1</td></tr><tr><td> </td><td>Karitiana (KAR)</td><td>17</td><td>0.02</td><td>0.90</td><td>97.06</td><td>2.94</td><td>90.48</td><td>4.76</td><td>4.76</td><td>1</td></tr><tr><td> </td><td>Surui* (SUR)</td><td>15</td><td>1.52</td><td>0.22</td><td>26.67</td><td>73.33</td><td>10.53</td><td>26.31</td><td>63.16</td><td>1</td></tr></table>
<table><tr><td>Main Geographic Region</td></tr><tr><td></td></tr><tr><td>Sub-Saharan Africans</td></tr><tr><td></td></tr><tr><td></td></tr><tr><td></td></tr><tr><td>North-African/Middle East</td></tr><tr><td></td></tr><tr><td></td></tr><tr><td></td></tr><tr><td>European</td></tr><tr><td></td></tr><tr><td></td></tr><tr><td></td></tr><tr><td></td></tr><tr><td></td></tr><tr><td>Central-South Asians</td></tr><tr><td></td></tr><tr><td></td></tr><tr><td></td></tr><tr><td></td></tr><tr><td></td></tr><tr><td></td></tr><tr><td>Eastern Asians</td></tr><tr><td></td></tr><tr><td></td></tr><tr><td></td></tr><tr><td></td></tr><tr><td>Oceania</td></tr><tr><td>Americans</td></tr><tr><td></td></tr><tr><td></td></tr><tr><td></td></tr></table>
<table><tr><td>Populations (ID)</td><td>Individuals</td><td colspan="2">HWE</td><td colspan="2">(%) allele frequencies LCE3 C_LCE3B-del</td><td colspan="3">SNP genotype frequencies (%)</td><td>LD</td></tr><tr><td></td><td></td><td>x2</td><td>p-value</td><td>+</td><td>−</td><td>AA</td><td>AG</td><td>GG</td><td>r2</td></tr><tr><td>Pygmies* (PYG)</td><td>44</td><td>0.93</td><td>0.33</td><td>64.77</td><td>35.23</td><td>0</td><td>13.64</td><td>86.36</td><td>0.013</td></tr><tr><td>Mandenka (MAN)</td><td>17</td><td>0.78</td><td>0.56</td><td>58.82</td><td>41.18</td><td>4.55</td><td>22.73</td><td>72.73</td><td>0.121</td></tr><tr><td>Yoruba (YRI)</td><td>22</td><td>2.18</td><td>0.14</td><td>65.91</td><td>34.09</td><td>0</td><td>28.57</td><td>71.43</td><td>0.089</td></tr><tr><td>Bantu (BAN)</td><td>18</td><td>2.66</td><td>0.10</td><td>72.22</td><td>27.78</td><td>0</td><td>50.00</td><td>50.00</td><td>0</td></tr><tr><td>Mozabite* (ALG)</td><td>26</td><td>0.04</td><td>0.84</td><td>32.69</td><td>67.31</td><td>0</td><td>21.43</td><td>78.57</td><td>0.256</td></tr><tr><td>Bedouin* (BED)</td><td>36</td><td>0.47</td><td>0.49</td><td>47.22</td><td>52.78</td><td>14.63</td><td>53.66</td><td>31.71</td><td>0.772</td></tr><tr><td>Druze* (DRU)</td><td>37</td><td>1.87</td><td>0.17</td><td>36.49</td><td>63.51</td><td>9.09</td><td>56.82</td><td>34.09</td><td>1</td></tr><tr><td>Palestinian (PAL)</td><td>40</td><td>0.44</td><td>0.50</td><td>31.25</td><td>68.75</td><td>4.44</td><td>44.44</td><td>51.11</td><td>0.936</td></tr><tr><td>French (FRA)</td><td>27</td><td>1.47</td><td>0.23</td><td>40.74</td><td>59.26</td><td>16.67</td><td>41.67</td><td>41.67</td><td>1</td></tr><tr><td>French Basque* (BASQ)</td><td>21</td><td>1.70</td><td>0.19</td><td>40.48</td><td>59.52</td><td>9.09</td><td>54.55</td><td>36.36</td><td>0.91</td></tr><tr><td>Sardinian* (SARD)</td><td>24</td><td>0</td><td>0.97</td><td>29.17</td><td>70.83</td><td>13.04</td><td>47.83</td><td>39.13</td><td>1</td></tr><tr><td>Italian (ITL)</td><td>17</td><td>0.28</td><td>0.60</td><td>31.76</td><td>38.24</td><td>35.00</td><td>40.00</td><td>25.00</td><td>1</td></tr><tr><td>Orcadian* (ORC)</td><td>16</td><td>2.80</td><td>0.09</td><td>31.25</td><td>68.75</td><td>23.08</td><td>23.08</td><td>53.85</td><td>1</td></tr><tr><td>Russian (RUS)</td><td>23</td><td>0.18</td><td>0.68</td><td>39.13</td><td>60.87</td><td>14.29</td><td>42.86</td><td>42.86</td><td>0.897</td></tr><tr><td>Brahui (BRA)</td><td>22</td><td>0.61</td><td>0.44</td><td>43.18</td><td>56.82</td><td>21.74</td><td>43.48</td><td>34.78</td><td>1</td></tr><tr><td>Balochi (BAL)</td><td>18</td><td>0.21</td><td>0.65</td><td>27.78</td><td>72.22</td><td>5.00</td><td>40.00</td><td>55.00</td><td>0.852</td></tr><tr><td>Makrani (MAK)</td><td>24</td><td>0.67</td><td>0.41</td><td>50.00</td><td>50.00</td><td>23.81</td><td>42.86</td><td>33.33</td><td>0.55</td></tr><tr><td>Sindhi (SIN)</td><td>21</td><td>1.71</td><td>0.19</td><td>33.33</td><td>66.67</td><td>0</td><td>50.00</td><td>50.00</td><td>0.905</td></tr><tr><td>Kalash* (KAL)</td><td>24</td><td>1.53</td><td>0.22</td><td>47.92</td><td>52.08</td><td>16.67</td><td>55.56</td><td>27.78</td><td>0.861</td></tr><tr><td>Burusho (BUR)</td><td>23</td><td>3.19</td><td>0.07</td><td>41.30</td><td>58.70</td><td>27.27</td><td>31.82</td><td>40.91</td><td>1</td></tr><tr><td>Hazara ( HAZ)</td><td>17</td><td>1.14</td><td>0.29</td><td>79.41</td><td>20.59</td><td>43.75</td><td>56.25</td><td>0</td><td>0.904</td></tr><tr><td>Han (CHB)</td><td>34</td><td>0</td><td>0.98</td><td>38.24</td><td>61.76</td><td>0</td><td>52.17</td><td>47.83</td><td>0.468</td></tr><tr><td>Japanese (JPN)</td><td>26</td><td>2.45</td><td>0.12</td><td>48.08</td><td>51.92</td><td>50.00</td><td>37.93</td><td>37.93</td><td>0.837</td></tr><tr><td>Yaut* (YAK)</td><td>11</td><td>0.55</td><td>0.46</td><td>77.27</td><td>22.73</td><td>50.00</td><td>31.82</td><td>18.18</td><td>1</td></tr><tr><td>NEA</td><td>34</td><td>0.54</td><td>0.46</td><td>45.59</td><td>54.41</td><td>20.59</td><td>52.94</td><td>26.47</td><td>0.852</td></tr><tr><td>SEA</td><td>36</td><td>0.73</td><td>0.40</td><td>29.17</td><td>70.83</td><td>5.88</td><td>50.00</td><td>44.12</td><td>0.537</td></tr><tr><td>Papuan-Melasian (OCE)</td><td>35</td><td>2.31</td><td>0.13</td><td>50.00</td><td>50.00</td><td>26.47</td><td>41.18</td><td>32.35</td><td>0.935</td></tr><tr><td>PIMA</td><td>22</td><td>0.51</td><td>0.48</td><td>25.00</td><td>75.00</td><td>9.09</td><td>36.36</td><td>54.55</td><td>0.804</td></tr><tr><td>MAYA</td><td>21</td><td>0.94</td><td>0.33</td><td>38.10</td><td>61.90</td><td>7.14</td><td>57.14</td><td>35.71</td><td>1</td></tr><tr><td>Karitiana (KAR)</td><td>17</td><td>0.02</td><td>0.90</td><td>97.06</td><td>2.94</td><td>90.48</td><td>4.76</td><td>4.76</td><td>1</td></tr><tr><td>Surui* (SUR)</td><td>15</td><td>1.52</td><td>0.22</td><td>26.67</td><td>73.33</td><td>10.53</td><td>26.31</td><td>63.16</td><td>1</td></tr></table>
708c12bae4b8e365ad594b2caa095875a8fe0c114521e3739df66148293187ba.png
complex
<table><tr><td rowspan="2"></td><td colspan="4">OR or &#946;*&#8224; (95% CI)</td></tr><tr><td>Iron score</td><td>Ferritin score</td><td>Transferrin score</td><td>Transferrin saturation score</td></tr><tr><td>Atopy (n=2208)</td><td></td><td></td><td></td><td></td></tr><tr><td> Per SD increase</td><td>1.08 (0.97 to 1.19)</td><td>1.06 (0.95 to 1.17)</td><td>0.97 (0.88 to 1.07)</td><td>1.05 (0.95 to 1.17)</td></tr><tr><td> P for trend</td><td>0.15</td><td>0.28</td><td>0.56</td><td>0.31</td></tr><tr><td>Asthma (n=2787)</td><td></td><td></td><td></td><td></td></tr><tr><td> Per SD increase</td><td>1.09 (0.97 to 1.22)</td><td>0.98 (0.88 to 1.10)</td><td>1.00 (0.90 to 1.12)</td><td>1.08 (0.96 to 1.21)</td></tr><tr><td> P for trend</td><td>0.15</td><td>0.75</td><td>0.95</td><td>0.20</td></tr><tr><td>FEV<sub>1</sub> (n=2300)</td><td></td><td></td><td></td><td></td></tr><tr><td> Per SD increase</td><td>&#8722;0.04 (&#8722;0.08 to 0.00)</td><td>&#8722;0.02 (&#8722;0.06 to 0.02)</td><td>&#8722;0.03 (&#8722;0.07 to 0.01)</td><td>&#8722;0.05 (&#8722;0.09 to &#8722;0.01)</td></tr><tr><td> P for trend</td><td>0.07</td><td>0.38</td><td>0.13</td><td>0.03</td></tr><tr><td>FVC (n=2336)</td><td></td><td></td><td></td><td></td></tr><tr><td> Per SD increase</td><td>&#8722;0.03 (&#8722;0.07 to 0.01)</td><td>&#8722;0.01 (&#8722;0.05 to 0.03)</td><td>&#8722;0.03 (&#8722;0.07 to 0.01)</td><td>&#8722;0.04 (&#8722;0.08 to 0.00)</td></tr><tr><td> P for trend</td><td>0.12</td><td>0.72</td><td>0.14</td><td>0.04</td></tr><tr><td>FEF<sub>25-75</sub> (n=2336)</td><td></td><td></td><td></td><td></td></tr><tr><td> Per SD increase</td><td>&#8722;0.02 (&#8722;0.06 to 0.02)</td><td>&#8722;0.02 (&#8722;0.06 to 0.02)</td><td>&#8722;0.02 (&#8722;0.06 to 0.02)</td><td>&#8722;0.02 (&#8722;0.06 to 0.02)</td></tr><tr><td> P for trend</td><td>0.35</td><td>0.39</td><td>0.36</td><td>0.28</td></tr></table>
<table><tr><td rowspan="2"></td><td colspan="4">OR or β*† (95% CI)</td></tr><tr><td>Iron score</td><td>Ferritin score</td><td>Transferrin score</td><td>Transferrin saturation score</td></tr><tr><td>Atopy (n=2208)</td><td></td><td></td><td></td><td></td></tr><tr><td>Per SD increase</td><td>1.08 (0.97 to 1.19)</td><td>1.06 (0.95 to 1.17)</td><td>0.97 (0.88 to 1.07)</td><td>1.05 (0.95 to 1.17)</td></tr><tr><td>P for trend</td><td>0.15</td><td>0.28</td><td>0.56</td><td>0.31</td></tr><tr><td>Asthma (n=2787)</td><td></td><td></td><td></td><td></td></tr><tr><td>Per SD increase</td><td>1.09 (0.97 to 1.22)</td><td>0.98 (0.88 to 1.10)</td><td>1.00 (0.90 to 1.12)</td><td>1.08 (0.96 to 1.21)</td></tr><tr><td>P for trend</td><td>0.15</td><td>0.75</td><td>0.95</td><td>0.20</td></tr><tr><td>FEV1 (n=2300)</td><td></td><td></td><td></td><td></td></tr><tr><td>Per SD increase</td><td>−0.04 (−0.08 to 0.00)</td><td>−0.02 (−0.06 to 0.02)</td><td>−0.03 (−0.07 to 0.01)</td><td>−0.05 (−0.09 to −0.01)</td></tr></table>
<table><tr><td>P for trend</td><td>0.07</td><td>0.38</td><td>0.13</td><td>0.03</td></tr><tr><td>FVC (n=2336)</td><td></td><td></td><td></td><td></td></tr><tr><td>Per SD increase</td><td>−0.03 (−0.07 to 0.01)</td><td>−0.01 (−0.05 to 0.03)</td><td>−0.03 (−0.07 to 0.01)</td><td>−0.04 (−0.08 to 0.00)</td></tr><tr><td>P for trend</td><td>0.12</td><td>0.72</td><td>0.14</td><td>0.04</td></tr><tr><td>FEF25-75 (n=2336)</td><td></td><td></td><td></td><td></td></tr><tr><td>Per SD increase</td><td>−0.02 (−0.06 to 0.02)</td><td>−0.02 (−0.06 to 0.02)</td><td>−0.02 (−0.06 to 0.02)</td><td>−0.02 (−0.06 to 0.02)</td></tr><tr><td>P for trend</td><td>0.35</td><td>0.39</td><td>0.36</td><td>0.28</td></tr></table>
46e608d3d6319199388e33619fc01cd7e828455e5e1a33e68d53bc4f745fe59b.png
simple
<table><tr><td>Patient</td><td>Sex</td><td>Age (years)</td><td>Time from implantation until removal (months)</td><td>Implant Material</td><td>Location</td><td>Reason for removal</td><td>Broken Screws?</td></tr><tr><td>1</td><td>Female</td><td>48</td><td>11</td><td>Ti</td><td>PU</td><td>Nonunion</td><td>No</td></tr><tr><td>2</td><td>Female</td><td>27</td><td>23</td><td>Ti</td><td>DH</td><td>Symptoms</td><td>Yes</td></tr><tr><td>3</td><td>Female</td><td>34</td><td>5</td><td>Ti</td><td>PU</td><td>Infection</td><td>No</td></tr><tr><td>4</td><td>Male</td><td>40</td><td>48</td><td>SS</td><td>DH</td><td>Contracture</td><td>No</td></tr><tr><td>5</td><td>Male</td><td>30</td><td>74</td><td>SS</td><td>PU</td><td>Infection</td><td>No</td></tr><tr><td>6</td><td>Female</td><td>25</td><td>38</td><td>Ti</td><td>Both</td><td>Nonunion</td><td>No</td></tr><tr><td>7</td><td>Male</td><td>44</td><td>2</td><td>Ti</td><td>Both</td><td>Infection</td><td>No</td></tr><tr><td>8</td><td>Female</td><td>43</td><td>5</td><td>SS</td><td>PU</td><td>Symptoms</td><td>No</td></tr><tr><td>9</td><td>Female</td><td>30</td><td>12</td><td>Ti</td><td>PU</td><td>Symptoms</td><td>No</td></tr><tr><td>10</td><td>Female</td><td>57</td><td>9</td><td>Ti</td><td>PU</td><td>Symptoms</td><td>No</td></tr><tr><td>11</td><td>Female</td><td>46</td><td>33</td><td>SS</td><td>Both</td><td>Nonunion</td><td>No</td></tr><tr><td>12</td><td>Male</td><td>24</td><td>8</td><td>SS</td><td>PU</td><td>Infection</td><td>No</td></tr><tr><td>13</td><td>Male</td><td>47</td><td>4</td><td>Ti</td><td>DH</td><td>Infection</td><td>No</td></tr><tr><td>14</td><td>Female</td><td>40</td><td>9</td><td>SS</td><td>Both*</td><td>Symptoms</td><td>Yes</td></tr><tr><td>15</td><td>Male</td><td>17</td><td>53</td><td>Ti</td><td>Both*</td><td>Nonunion</td><td>Yes</td></tr><tr><td>16</td><td>Male</td><td>56</td><td>25</td><td>Ti</td><td>DH</td><td>Symptoms</td><td>Yes</td></tr><tr><td>17</td><td>Female</td><td>35</td><td>64</td><td>Ti</td><td>DH</td><td>Infection</td><td>Yes</td></tr><tr><td>18</td><td>Female</td><td>48</td><td>12</td><td>Ti</td><td>PU</td><td>Symptoms</td><td>No</td></tr><tr><td>19</td><td>Male</td><td>27</td><td>8</td><td>SS</td><td>DH</td><td>Infection</td><td>No</td></tr><tr><td>20</td><td>Male</td><td>66</td><td>16</td><td>Ti</td><td>PU</td><td>Nonunion</td><td>Yes</td></tr><tr><td>21</td><td>Male</td><td>28</td><td>7</td><td>Ti</td><td>Both</td><td>Nonunion</td><td>No</td></tr></table>
<table><tr><td>Patient</td><td>Sex</td><td>Age (years)</td><td>Time from implantation until removal (months)</td><td>Implant Material</td><td>Location</td><td>Reason for removal</td><td>Broken Screws?</td></tr><tr><td>1</td><td>Female</td><td>48</td><td>11</td><td>Ti</td><td>PU</td><td>Nonunion</td><td>No</td></tr><tr><td>2</td><td>Female</td><td>27</td><td>23</td><td>Ti</td><td>DH</td><td>Symptoms</td><td>Yes</td></tr><tr><td>3</td><td>Female</td><td>34</td><td>5</td><td>Ti</td><td>PU</td><td>Infection</td><td>No</td></tr><tr><td>4</td><td>Male</td><td>40</td><td>48</td><td>SS</td><td>DH</td><td>Contracture</td><td>No</td></tr><tr><td>5</td><td>Male</td><td>30</td><td>74</td><td>SS</td><td>PU</td><td>Infection</td><td>No</td></tr><tr><td>6</td><td>Female</td><td>25</td><td>38</td><td>Ti</td><td>Both</td><td>Nonunion</td><td>No</td></tr><tr><td>7</td><td>Male</td><td>44</td><td>2</td><td>Ti</td><td>Both</td><td>Infection</td><td>No</td></tr><tr><td>8</td><td>Female</td><td>43</td><td>5</td><td>SS</td><td>PU</td><td>Symptoms</td><td>No</td></tr><tr><td>9</td><td>Female</td><td>30</td><td>12</td><td>Ti</td><td>PU</td><td>Symptoms</td><td>No</td></tr><tr><td>10</td><td>Female</td><td>57</td><td>9</td><td>Ti</td><td>PU</td><td>Symptoms</td><td>No</td></tr><tr><td>11</td><td>Female</td><td>46</td><td>33</td><td>SS</td><td>Both</td><td>Nonunion</td><td>No</td></tr><tr><td>12</td><td>Male</td><td>24</td><td>8</td><td>SS</td><td>PU</td><td>Infection</td><td>No</td></tr><tr><td>13</td><td>Male</td><td>47</td><td>4</td><td>Ti</td><td>DH</td><td>Infection</td><td>No</td></tr></table>
<table><tr><td>Patient</td><td>Sex</td><td>Age (years)</td><td>Time from implantation until removal (months)</td><td>Implant Material</td><td>Location</td><td>Reason for removal</td><td>Broken Screws?</td></tr><tr><td>14</td><td>Female</td><td>40</td><td>9</td><td>SS</td><td>Both*</td><td>Symptoms</td><td>Yes</td></tr><tr><td>15</td><td>Male</td><td>17</td><td>53</td><td>Ti</td><td>Both*</td><td>Nonunion</td><td>Yes</td></tr><tr><td>16</td><td>Male</td><td>56</td><td>25</td><td>Ti</td><td>DH</td><td>Symptoms</td><td>Yes</td></tr><tr><td>17</td><td>Female</td><td>35</td><td>64</td><td>Ti</td><td>DH</td><td>Infection</td><td>Yes</td></tr><tr><td>18</td><td>Female</td><td>48</td><td>12</td><td>Ti</td><td>PU</td><td>Symptoms</td><td>No</td></tr><tr><td>19</td><td>Male</td><td>27</td><td>8</td><td>SS</td><td>DH</td><td>Infection</td><td>No</td></tr><tr><td>20</td><td>Male</td><td>66</td><td>16</td><td>Ti</td><td>PU</td><td>Nonunion</td><td>Yes</td></tr><tr><td>21</td><td>Male</td><td>28</td><td>7</td><td>Ti</td><td>Both</td><td>Nonunion</td><td>No</td></tr></table>
38a22e8c863722ce6570e14dbc334510472d136eb6d8346ebcf30ceee1a0f58f.png
complex
<table><tr><td rowspan="2">Genotype</td><td>Control</td><td colspan="3">RPC*</td><td colspan="3">UC*</td><td colspan="3">Total UTUC</td></tr><tr><td>N (%)</td><td>N (%)</td><td>Odds ratio (95% CI*)</td><td>P</td><td>N (%)</td><td>Odds ratio (95% CI*)</td><td>P</td><td>N (%)</td><td>Odds ratio (95% CI*)</td><td>P</td></tr><tr><td><i>rs2736100 (N/%)</i></td><td>289</td><td>92</td><td></td><td></td><td>120</td><td></td><td></td><td>212</td><td></td><td></td></tr><tr><td>AA</td><td>86 (29.8)</td><td>34 (37.0)</td><td>1.0 (ref.)</td><td></td><td>49 (40.8)</td><td>1.0 (ref.)</td><td></td><td>83 (39.2)</td><td>1.0 (ref.)</td><td></td></tr><tr><td>AC</td><td>144 (49.8)</td><td>32 (34.8)</td><td>0.562 (0.324 - 0.976)</td><td>0.055</td><td>49 (40.8)</td><td>0.597 (0.370 - 0.963)</td><td>0.045</td><td>81 (38.2)</td><td>0.583 (0.388 - 0.875)</td><td>0.012</td></tr><tr><td>CC</td><td>59 (20.4)</td><td>26 (28.2)</td><td>1.115 (0.606 - 2.049)</td><td>0.846</td><td>22 (18.4)</td><td>0.714 (0.396 - 1.288)</td><td>0.330</td><td>48 (22.6)</td><td>0.878 (0.542 - 1.423)</td><td>0.685</td></tr><tr><td>AA + CC</td><td>145 (50)</td><td>60 (65)</td><td>1.0 (ref.*)</td><td></td><td>71 (59.2)</td><td>1.0 (ref.)</td><td></td><td>133(62.1)</td><td>1.0 (ref.)</td><td></td></tr><tr><td>AC</td><td>144 (49.8)</td><td>32 (35)</td><td>0.537 (0.330 - 0.874)</td><td>0.016</td><td>49 (40.8)</td><td>0.695 (0.452 - 1.069)</td><td>0.121</td><td>81 (37.9)</td><td>0.613 (0.428 - 0.879)</td><td>0.010</td></tr></table>
<table><tr><td rowspan="2">Genotype</td><td>Control</td><td colspan="3">RPC*</td><td>UC*</td></tr><tr><td>N (%)</td><td>N (%)</td><td>Odds ratio (95% CI*)</td><td>P</td><td>N (%)</td></tr><tr><td>rs2736100 (N/%)</td><td>289</td><td>92</td><td></td><td></td><td>120</td></tr><tr><td>AA</td><td>86 (29.8)</td><td>34 (37.0)</td><td>1.0 (ref.)</td><td></td><td>49 (40.8)</td></tr><tr><td>AC</td><td>144 (49.8)</td><td>32 (34.8)</td><td>0.562 (0.324 - 0.976)</td><td>0.055</td><td>49 (40.8)</td></tr><tr><td>CC</td><td>59 (20.4)</td><td>26 (28.2)</td><td>1.115 (0.606 - 2.049)</td><td>0.846</td><td>22 (18.4)</td></tr><tr><td>AA + CC</td><td>145 (50)</td><td>60 (65)</td><td>1.0 (ref.*)</td><td></td><td>71 (59.2)</td></tr><tr><td>AC</td><td>144 (49.8)</td><td>32 (35)</td><td>0.537 (0.330 - 0.874)</td><td>0.016</td><td>49 (40.8)</td></tr></table>
<table><tr><td colspan="2">UC*</td><td colspan="3">Total UTUC</td></tr><tr><td>Odds ratio (95% CI*)</td><td>P</td><td>N (%)</td><td>Odds ratio (95% CI*)</td><td>P</td></tr><tr><td></td><td></td><td>212</td><td></td><td></td></tr><tr><td>1.0 (ref.)</td><td></td><td>83 (39.2)</td><td>1.0 (ref.)</td><td></td></tr><tr><td>0.597 (0.370 - 0.963)</td><td>0.045</td><td>81 (38.2)</td><td>0.583 (0.388 - 0.875)</td><td>0.012</td></tr><tr><td>0.714 (0.396 - 1.288)</td><td>0.330</td><td>48 (22.6)</td><td>0.878 (0.542 - 1.423)</td><td>0.685</td></tr><tr><td>1.0 (ref.)</td><td></td><td>133(62.1)</td><td>1.0 (ref.)</td><td></td></tr><tr><td>0.695 (0.452 - 1.069)</td><td>0.121</td><td>81 (37.9)</td><td>0.613 (0.428 - 0.879)</td><td>0.010</td></tr></table>
46f49bf5d5cd11baa846aeb10385b53f976dca13bf0c369147d491ed749503c2.png
simple
<table><tr><td>Isolate no.</td><td>A<sub>600</sub></td><td>Residual Cr(VI)<sup>a </sup>(mM)</td><td>% Cr(VI) reduced</td><td>Cr(VI) transformed per A<sub>600 </sub>of growth</td></tr><tr><td>TSB-1</td><td>0.56</td><td>0</td><td>100</td><td>1.79</td></tr><tr><td>TSB-2</td><td>0.65</td><td>0</td><td>100</td><td>1.54</td></tr><tr><td>TSB-3</td><td>0.3</td><td>0.4</td><td>60</td><td>2.00</td></tr><tr><td>TSB-4</td><td>0.251</td><td>0.6</td><td>40</td><td>1.59</td></tr><tr><td>TSB-5</td><td>0.690</td><td>0</td><td>100</td><td>1.45</td></tr><tr><td>TSB-7</td><td>0.325</td><td>0.65</td><td>35</td><td>1.08</td></tr><tr><td>TSB-8</td><td>0.202</td><td>0.68</td><td>32</td><td>1.58</td></tr><tr><td>TSB-9</td><td>0.0.596</td><td>0</td><td>100</td><td>1.68</td></tr><tr><td>TSB-10</td><td>0.42</td><td>0.66</td><td>34</td><td>0.81</td></tr><tr><td>TSB-11</td><td>0.695</td><td>0</td><td>100</td><td>1.44</td></tr></table>
<table><tr><td>Isolate no.</td><td>A600</td><td>Residual Cr(VI)a (mM)</td><td>% Cr(VI) reduced</td><td>Cr(VI) transformed per A600 of growth</td></tr><tr><td>TSB-1</td><td>0.56</td><td>0</td><td>100</td><td>1.79</td></tr></table>
<table><tr><td>TSB-2</td><td>0.65</td><td>0</td><td>100</td><td>1.54</td></tr><tr><td>TSB-3</td><td>0.3</td><td>0.4</td><td>60</td><td>2.00</td></tr><tr><td>TSB-4</td><td>0.251</td><td>0.6</td><td>40</td><td>1.59</td></tr><tr><td>TSB-5</td><td>0.690</td><td>0</td><td>100</td><td>1.45</td></tr><tr><td>TSB-7</td><td>0.325</td><td>0.65</td><td>35</td><td>1.08</td></tr><tr><td>TSB-8</td><td>0.202</td><td>0.68</td><td>32</td><td>1.58</td></tr><tr><td>TSB-9</td><td>0.0.596</td><td>0</td><td>100</td><td>1.68</td></tr><tr><td>TSB-10</td><td>0.42</td><td>0.66</td><td>34</td><td>0.81</td></tr><tr><td>TSB-11</td><td>0.695</td><td>0</td><td>100</td><td>1.44</td></tr></table>
da0dc623a8cccee86574b5e79df5b88f1f2b474b5320ecc34ffc822bfd49f78d.png
simple
<table><tr><td>Lesion [sources]</td><td>HPV prevalence</td><td>HPV 6/11/16/18 attributable fraction among HPV+ cases</td><td>HPV 6/11/16/18/31/33/45/52/58 attributable fraction among HPV+ cases</td><td>HPV 31/33/45/52/58 absolute (relative) attributable fraction among HPV+ cases</td></tr><tr><td>Genital warts [2]</td><td>100%</td><td>90%</td><td>90%</td><td>0% (0%)</td></tr><tr><td>CIN 2/3 [2]</td><td>100%</td><td>45.5%</td><td>82.3%</td><td>36.8% (80.9%)</td></tr><tr><td>VIN2/3 [8]</td><td>86.9%</td><td>80.9%</td><td>93.9%</td><td>13.0% (16.1%)</td></tr><tr><td>VaIN 2/3 [9]</td><td>98.0%</td><td>65.7%</td><td>79.0%</td><td>13.3% (20.2%)</td></tr><tr><td>AIN 2/3 [22]</td><td>95.7%</td><td>80.5%</td><td>87.8%</td><td>7.3% (9.1%)</td></tr><tr><td>PIN 2/3 [10]</td><td>89.1%</td><td>81.0%</td><td>91.9%</td><td>10.9% (13.4%)</td></tr><tr><td>Cervical cancer [21]</td><td>100%</td><td>72.4%(a)</td><td>88.3%(a)</td><td>15.9% (21.9%)(a)</td></tr><tr><td>Vulvar cancer [8]</td><td>18.3% (b)</td><td>78.0%</td><td>91.6%</td><td>13.6% (17.4%)</td></tr><tr><td>Vaginal cancer [9]</td><td>71.0%</td><td>64.0%(a)</td><td>84.2%(a)</td><td>20.2% (31.6%)(a)</td></tr><tr><td>Anal cancer [22]</td><td>87.6%</td><td>84.3%(a)</td><td>92.3%(a)</td><td>8.0% (9.5%)(a)</td></tr><tr><td>Penile cancer [10]</td><td>32.2%</td><td>70.2%(a)</td><td>79.4%(a)</td><td>9.2% (13.1%)(a)</td></tr><tr><td>Oral cavity [23]</td><td>7.4%</td><td>72.0%(a)</td><td>80.6%(a)</td><td>8.6% (11.9%)(a)</td></tr><tr><td>Nasopharynx [23]</td><td>7,9%</td><td>75.0%(a)</td><td>87.5%(a)</td><td>12.5% (16.7%)(a)</td></tr><tr><td>Oropharynx cancer [23]</td><td>24.9%</td><td>85.2%(a)</td><td>89.7%(a)</td><td>4.5% (5.3%)(a)</td></tr><tr><td>Hypopharynx cancer [23]</td><td>3.9%</td><td>80.0%(a)</td><td>100%(a)</td><td>20.0% (25.0%)(a)</td></tr><tr><td>Pharynx cancer [23]</td><td>21.4%</td><td>66.7%(a)</td><td>66.7%(a)</td><td>0% (0%)(a)</td></tr><tr><td>Larynx cancer [23]</td><td>5.7%</td><td>57.6%(a)</td><td>74.6%(a)</td><td>17.0% (29.5%)(a)</td></tr></table>
<table><tr><td>Lesion [sources]</td><td>HPV prevalence</td><td>HPV 6/11/16/18 attributable fraction among HPV+ cases</td><td>HPV 6/11/16/18/31/33/45/52/58 attributable fraction among HPV+ cases</td><td>HPV 31/33/45/52/58 absolute (relative) attributable fraction among HPV+ cases</td></tr><tr><td>Genital warts [2]</td><td>100%</td><td>90%</td><td>90%</td><td>0% (0%)</td></tr><tr><td>CIN 2/3 [2]</td><td>100%</td><td>45.5%</td><td>82.3%</td><td>36.8% (80.9%)</td></tr><tr><td>VIN2/3 [8]</td><td>86.9%</td><td>80.9%</td><td>93.9%</td><td>13.0% (16.1%)</td></tr></table>
<table><tr><td>VaIN 2/3 [9]</td><td>98.0%</td><td>65.7%</td><td>79.0%</td><td>13.3% (20.2%)</td></tr><tr><td>AIN 2/3 [22]</td><td>95.7%</td><td>80.5%</td><td>87.8%</td><td>7.3% (9.1%)</td></tr><tr><td>PIN 2/3 [10]</td><td>89.1%</td><td>81.0%</td><td>91.9%</td><td>10.9% (13.4%)</td></tr><tr><td>Cervical cancer [21]</td><td>100%</td><td>72.4%(a)</td><td>88.3%(a)</td><td>15.9% (21.9%)(a)</td></tr><tr><td>Vulvar cancer [8]</td><td>18.3% (b)</td><td>78.0%</td><td>91.6%</td><td>13.6% (17.4%)</td></tr><tr><td>Vaginal cancer [9]</td><td>71.0%</td><td>64.0%(a)</td><td>84.2%(a)</td><td>20.2% (31.6%)(a)</td></tr><tr><td>Anal cancer [22]</td><td>87.6%</td><td>84.3%(a)</td><td>92.3%(a)</td><td>8.0% (9.5%)(a)</td></tr><tr><td>Penile cancer [10]</td><td>32.2%</td><td>70.2%(a)</td><td>79.4%(a)</td><td>9.2% (13.1%)(a)</td></tr><tr><td>Oral cavity [23]</td><td>7.4%</td><td>72.0%(a)</td><td>80.6%(a)</td><td>8.6% (11.9%)(a)</td></tr><tr><td>Nasopharynx [23]</td><td>7,9%</td><td>75.0%(a)</td><td>87.5%(a)</td><td>12.5% (16.7%)(a)</td></tr><tr><td>Oropharynx cancer [23]</td><td>24.9%</td><td>85.2%(a)</td><td>89.7%(a)</td><td>4.5% (5.3%)(a)</td></tr><tr><td>Hypopharynx cancer [23]</td><td>3.9%</td><td>80.0%(a)</td><td>100%(a)</td><td>20.0% (25.0%)(a)</td></tr><tr><td>Pharynx cancer [23]</td><td>21.4%</td><td>66.7%(a)</td><td>66.7%(a)</td><td>0% (0%)(a)</td></tr><tr><td>Larynx cancer [23]</td><td>5.7%</td><td>57.6%(a)</td><td>74.6%(a)</td><td>17.0% (29.5%)(a)</td></tr></table>
20fbfc952daa3d18d3c0730e35422464b67f932dd5cd4ca1d5f0620e3e7e72db.png
simple
<table><tr><td>Concrete resistivity &#961; (k&#937;cm)</td><td>Probable corrosion rate</td></tr><tr><td>&gt;20</td><td>Despicable</td></tr><tr><td>Between 10 and 20</td><td>Low</td></tr><tr><td>Between 5 and 10</td><td>High</td></tr><tr><td>&lt;5</td><td>Very high</td></tr></table>
<table><tr><td>Concrete resistivity ρ (kΩcm)</td><td>Probable corrosion rate</td></tr><tr><td>>20</td><td>Despicable</td></tr><tr><td>Between 10 and 20</td><td>Low</td></tr></table>
<table><tr><td>Between 5 and 10</td><td>High</td></tr><tr><td><5</td><td>Very high</td></tr></table>
457846dddce6e49f084634b61164fe80fec9245800951158d9059efb26991266.png
complex
<table><tr><td>Target viruses<sup>a</sup></td><td>Target genes<sup>b</sup></td><td>Primer sequence, 5&#8242;&#8211;3<sup>&#8242;c</sup></td><td>Size (bp)</td><td>Source or reference</td></tr><tr><td>PToV</td><td>S</td><td>F: ACCCCTGCCTGAGGTTTCYTTR: AGCACGACGTTGTCTRCGTGT</td><td>451</td><td>Established by our own laboratory</td></tr><tr><td>PEDV</td><td>S</td><td>F: TTCTGAGTCACGAACAGCCAR: CATATGCAGCCTGCTCTGAA</td><td>651</td><td>Kim et al. (2001) [11]</td></tr><tr><td>PKBV</td><td>3D</td><td>F: TGGATTACAAGTGTTTTGATGCR: TGTCGTAGAACTCCTTGATGAA</td><td>313</td><td>Established by our own laboratory</td></tr><tr><td rowspan="2"> PRV A</td><td rowspan="2"> VP6</td><td>F: AAAGATGCTAGGGACAAAATTGR: TTCAGATTGTGGAGCTATTCCA</td><td>308</td><td rowspan="2"> Elschner et al. (2002) [12]</td></tr><tr><td>nF: GACAAAATTGTCGAAGGCACATTATAnR: TCGGTAGATTACCAATTCCTCCAG</td><td>121</td></tr><tr><td>PRV B</td><td>NSP2</td><td>F: CTATTCAGTGTGTCGTGAGAGG R: GCAGACAAGCTAGCCCGCTTCG</td><td>434</td><td>Gouvea et al. (1991) [13]</td></tr><tr><td rowspan="2"> PRV C</td><td rowspan="2">VP6</td><td>F: CTCGATGCTACTACAGAATCAGR: AGCCACATAGTTCACATTTCATCC</td><td>366</td><td rowspan="2"> Gouvea et al. (1991) [13]</td></tr><tr><td>nF: CTCGATGCTACTACAGAATCAGnR: GGGATCATCCACGTCATGCGT</td><td>328</td></tr><tr><td rowspan="2">TGEV</td><td>ORF1b</td><td rowspan="2">F: GGGTAAGTTGCTCATTAGAAATAATGGR: CTTCTTCAAAGCTAGGGACTG</td><td rowspan="2">1006</td><td rowspan="2">Kim et al. (2010) [14]</td></tr><tr><td>S</td></tr><tr><td>AV</td><td>RdRp</td><td>F11: GARTTYGATTGGRCKCGKTAYGAF12: GARTTYGATTGGRCKAGGTAYGAF21: CGKTAYGATGGKACKATHCF22: AGGTAYGATGGKACKATHCR1: GGYTTKACCCACATICCRAA</td><td>422</td><td>Chu et al. (2008) [15]</td></tr><tr><td rowspan="2"> MRV</td><td rowspan="2">L1</td><td>F: GCATCCATTGTAAATGACGAGTCTGR: CTTGAGATTAGCTCTAGCATCTTCTG</td><td>416</td><td rowspan="2"> Decaro et al. (2005) [16]</td></tr><tr><td>nF: GCTAGGCCGATATCGGGAATGCAGnR: GTCTCACTATTCACCTTACCAGCAG</td><td>344</td></tr><tr><td>PSaV and PNoV</td><td>RdRp</td><td>F: GATTACTCCAAGTGGGACTCCACR: TGACAATGTAATATCACCATA</td><td>319</td><td>Kim et al. (2010) [14]</td></tr></table>
<table><tr><td>Target virusesa</td><td>Target genesb</td><td>Primer sequence, 5′–3′c</td><td>Size (bp)</td><td>Source or reference</td></tr></table>
<table><tr><td>PToV</td><td>S</td><td>F: ACCCCTGCCTGAGGTTTCYTTR: AGCACGACGTTGTCTRCGTGT</td><td>451</td><td>Established by our own laboratory</td></tr><tr><td>PEDV</td><td>S</td><td>F: TTCTGAGTCACGAACAGCCAR: CATATGCAGCCTGCTCTGAA</td><td>651</td><td>Kim et al. (2001) [11]</td></tr><tr><td>PKBV</td><td>3D</td><td>F: TGGATTACAAGTGTTTTGATGCR: TGTCGTAGAACTCCTTGATGAA</td><td>313</td><td>Established by our own laboratory</td></tr><tr><td rowspan="2">PRV A</td><td rowspan="2">VP6</td><td>F: AAAGATGCTAGGGACAAAATTGR: TTCAGATTGTGGAGCTATTCCA</td><td>308</td><td rowspan="2">Elschner et al. (2002) [12]</td></tr><tr><td>nF: GACAAAATTGTCGAAGGCACATTATAnR: TCGGTAGATTACCAATTCCTCCAG</td><td>121</td></tr><tr><td>PRV B</td><td>NSP2</td><td>F: CTATTCAGTGTGTCGTGAGAGG R: GCAGACAAGCTAGCCCGCTTCG</td><td>434</td><td>Gouvea et al. (1991) [13]</td></tr><tr><td rowspan="2">PRV C</td><td rowspan="2">VP6</td><td>F: CTCGATGCTACTACAGAATCAGR: AGCCACATAGTTCACATTTCATCC</td><td>366</td><td rowspan="2">Gouvea et al. (1991) [13]</td></tr><tr><td>nF: CTCGATGCTACTACAGAATCAGnR: GGGATCATCCACGTCATGCGT</td><td>328</td></tr><tr><td rowspan="2">TGEV</td><td>ORF1b</td><td rowspan="2">F: GGGTAAGTTGCTCATTAGAAATAATGGR: CTTCTTCAAAGCTAGGGACTG</td><td rowspan="2">1006</td><td rowspan="2">Kim et al. (2010) [14]</td></tr><tr><td>S</td></tr><tr><td>AV</td><td>RdRp</td><td>F11: GARTTYGATTGGRCKCGKTAYGAF12: GARTTYGATTGGRCKAGGTAYGAF21: CGKTAYGATGGKACKATHCF22: AGGTAYGATGGKACKATHCR1: GGYTTKACCCACATICCRAA</td><td>422</td><td>Chu et al. (2008) [15]</td></tr><tr><td rowspan="2">MRV</td><td rowspan="2">L1</td><td>F: GCATCCATTGTAAATGACGAGTCTGR: CTTGAGATTAGCTCTAGCATCTTCTG</td><td>416</td><td rowspan="2">Decaro et al. (2005) [16]</td></tr><tr><td>nF: GCTAGGCCGATATCGGGAATGCAGnR: GTCTCACTATTCACCTTACCAGCAG</td><td>344</td></tr><tr><td>PSaV and PNoV</td><td>RdRp</td><td>F: GATTACTCCAAGTGGGACTCCACR: TGACAATGTAATATCACCATA</td><td>319</td><td>Kim et al. (2010) [14]</td></tr></table>
a9cf2b64aefdf410ccdd6a55a875815091acbbeea331bb950c7f70504a44db2f.png
simple
<table><tr><td>Correlation between IGF-I/IGFBP-3 molar ratio and:</td><td>Total group (GHD and controls)</td><td>GHD group</td></tr><tr><td>Height SDS</td><td>+0.01</td><td>+0.16</td></tr><tr><td>BMI SDS for HA</td><td>+0.26</td><td>+0.24</td></tr><tr><td>Ghrelin</td><td>&#8722;0.35<sup>&#8727;</sup></td><td>&#8722;0.34<sup>&#8727;</sup></td></tr><tr><td>Leptin</td><td>+0.29</td><td>+0.34</td></tr><tr><td>Adiponectin</td><td>&#8722;0.15</td><td>&#8722;0.41<sup>&#8727;</sup></td></tr><tr><td>Resistin</td><td>&#8722;0.24</td><td>0.0</td></tr><tr><td>Triglycerides</td><td>+0.4<sup>&#8727;</sup></td><td>+0.59<sup>&#8727;</sup></td></tr><tr><td>Cholesterol</td><td>+0.22</td><td>+0.05</td></tr><tr><td>LDL-cholesterol</td><td>+0.16</td><td>+0.08</td></tr><tr><td>HDL-cholesterol</td><td>&#8722;0.04</td><td>&#8722;0.59<sup>&#8727;</sup></td></tr><tr><td>Glucose</td><td>+0.18</td><td>+0.2</td></tr><tr><td>Insulin</td><td>+0.41<sup>&#8727;</sup></td><td>+0.48<sup>&#8727;</sup></td></tr><tr><td>IRI HOMA</td><td>+0.36<sup>&#8727;</sup></td><td>+0.41<sup>&#8727;</sup></td></tr></table>
<table><tr><td>Correlation between IGF-I/IGFBP-3 molar ratio and:</td><td>Total group (GHD and controls)</td><td>GHD group</td></tr><tr><td>Height SDS</td><td>+0.01</td><td>+0.16</td></tr><tr><td>BMI SDS for HA</td><td>+0.26</td><td>+0.24</td></tr><tr><td>Ghrelin</td><td>−0.35∗</td><td>−0.34∗</td></tr><tr><td>Leptin</td><td>+0.29</td><td>+0.34</td></tr><tr><td>Adiponectin</td><td>−0.15</td><td>−0.41∗</td></tr><tr><td>Resistin</td><td>−0.24</td><td>0.0</td></tr><tr><td>Triglycerides</td><td>+0.4∗</td><td>+0.59∗</td></tr><tr><td>Cholesterol</td><td>+0.22</td><td>+0.05</td></tr><tr><td>LDL-cholesterol</td><td>+0.16</td><td>+0.08</td></tr><tr><td>HDL-cholesterol</td><td>−0.04</td><td>−0.59∗</td></tr></table>
<table><tr><td>Glucose</td><td>+0.18</td><td>+0.2</td></tr><tr><td>Insulin</td><td>+0.41∗</td><td>+0.48∗</td></tr><tr><td>IRI HOMA</td><td>+0.36∗</td><td>+0.41∗</td></tr></table>
0e79d2b3ee14fa9f4130671b5ed9ded36395ea80d7f5478dd485eb16b7f3815a.png
complex
<table><tr><td></td><td colspan="2">A2780</td><td colspan="2">A2780/CDDP</td><td colspan="2">SKOV3</td></tr><tr><td></td><td>control</td><td>BRCA1 si</td><td>control</td><td>BRCA1 si</td><td>control</td><td>BRCA1 si</td></tr><tr><td>G1</td><td>52.57&#177;5.11%</td><td>50.03&#177;4.88%</td><td>48.87&#177;4.76%</td><td>44.77&#177;5.71%</td><td>45.07&#177;4.1%</td><td>43.03&#177;2.71%</td></tr><tr><td>S</td><td>16.43&#177;3.18%</td><td>19.33&#177;2.81%</td><td>10.89&#177;2.18%</td><td>10.40&#177;3.23%</td><td>9.43&#177;5.18%</td><td>9.39&#177;1.86%</td></tr><tr><td>G2/M</td><td>19.73&#177;2.50%</td><td>21.37&#177;2.76%</td><td>28.83&#177;2.44%</td><td>29.39&#177;3.50%</td><td>23.03&#177;1.50%</td><td>23.99&#177;2.90%</td></tr></table>
<table><tr><td></td><td>A2780</td></tr><tr><td></td><td>control</td></tr><tr><td>G1</td><td>52.57±5.11%</td></tr><tr><td>S</td><td>16.43±3.18%</td></tr><tr><td>G2/M</td><td>19.73±2.50%</td></tr></table>
<table><tr><td>A2780</td><td colspan="2">A2780/CDDP</td><td colspan="2">SKOV3</td></tr><tr><td>BRCA1 si</td><td>control</td><td>BRCA1 si</td><td>control</td><td>BRCA1 si</td></tr><tr><td>50.03±4.88%</td><td>48.87±4.76%</td><td>44.77±5.71%</td><td>45.07±4.1%</td><td>43.03±2.71%</td></tr><tr><td>19.33±2.81%</td><td>10.89±2.18%</td><td>10.40±3.23%</td><td>9.43±5.18%</td><td>9.39±1.86%</td></tr><tr><td>21.37±2.76%</td><td>28.83±2.44%</td><td>29.39±3.50%</td><td>23.03±1.50%</td><td>23.99±2.90%</td></tr></table>
358657581c54a5b3bb6bf0f4d026893ac181d48f7b2b7644008f07a1ae54961b.png
complex
<table><tr><td rowspan="2">Epidemiological strata</td><td rowspan="2" colspan="3">Study sites</td><td colspan="3">Age (months)</td><td rowspan="2">Total</td></tr><tr><td>&lt; 60</td><td>60&#8211;119</td><td>120+</td></tr><tr><td rowspan="3">HWP</td><td rowspan="3">Bamenda</td><td rowspan="2">Gender</td><td>F</td><td>70 (40.5)</td><td>29 (16.8)</td><td>74 (42.8)</td><td>173 (54.4)</td></tr><tr><td>M</td><td>58 (40.0)</td><td>38 (26.2)</td><td>49 (33.8)</td><td>145 (45.6)</td></tr><tr><td colspan="2">Total</td><td>128 (40.3)</td><td>67 (21.1)</td><td>123 (38.7)</td><td>318</td></tr><tr><td rowspan="3">C</td><td rowspan="3">Limbe</td><td rowspan="2">Gender</td><td>F</td><td>75 (50.3)</td><td>39 (26.2)</td><td>35 (23.5)</td><td>149 (46.9)</td></tr><tr><td>M</td><td>103 (61.0)</td><td>39 (23.1)</td><td>27 (15.9)</td><td>169 (53.1)</td></tr><tr><td colspan="2">Total</td><td>178 (56.0)</td><td>78 (24.5)</td><td>62 (19.5)</td><td>318</td></tr><tr><td rowspan="3">SCEF</td><td rowspan="3">Yaounde</td><td rowspan="2">Gender</td><td>F</td><td>61 (40.7)</td><td>32 (21.3)</td><td>57 (38.0)</td><td>150 (44.0)</td></tr><tr><td>M</td><td>100 (52.4)</td><td>46 (24.1)</td><td>45 (23.6)</td><td>191 (56.0)</td></tr><tr><td colspan="2">Total</td><td>161 (47.2)</td><td>78 (22.9)</td><td>102 (29.9)</td><td>341</td></tr><tr><td rowspan="3">SS</td><td rowspan="3">Maroua</td><td rowspan="2">Gender</td><td>F</td><td>122 (74.4)</td><td>27 (16.5)</td><td>15 (9.1)</td><td>164 (52.1)</td></tr><tr><td>M</td><td>111 (73.5)</td><td>27 (17.9)</td><td>13 (8.6)</td><td>151 (47.9)</td></tr><tr><td colspan="2">Total</td><td>233 (74.0)</td><td>54 (17.1)</td><td>28 (8.9)</td><td>315</td></tr><tr><td rowspan="3">HIP</td><td rowspan="3">Ngaoundere</td><td rowspan="2">Gender</td><td>F</td><td>94 (65.7)</td><td>32 (22.4)</td><td>17 (11.9)</td><td>143 (45.1)</td></tr><tr><td>M</td><td>116 (66.7)</td><td>34 (19.5)</td><td>24 (13.8)</td><td>174 (54.9)</td></tr><tr><td colspan="2">Total</td><td>210 (66.3)</td><td>66 (20.8)</td><td>41 (12.9)</td><td>317</td></tr><tr><td rowspan="3" colspan="2">Total</td><td rowspan="2">Gender</td><td>F</td><td>422 (54.2)</td><td>159 (20.4)</td><td>198 (25.4)</td><td>779 (48.4)</td></tr><tr><td>M</td><td>488 (58.8)</td><td>184 (22.2)</td><td>158 (19.0)</td><td>830 (51.6)</td></tr><tr><td colspan="2">Total</td><td>910 (56.6)</td><td>343 (21.3)</td><td>356 (22.1)</td><td>1609</td></tr></table>
<table><tr><td rowspan="2">Epidemiological strata</td><td rowspan="2" colspan="3">Study sites</td><td colspan="3">Age (months)</td><td rowspan="2">Total</td></tr><tr><td>< 60</td><td>60–119</td><td>120+</td></tr><tr><td rowspan="3">HWP</td><td rowspan="3">Bamenda</td><td rowspan="2">Gender</td><td>F</td><td>70 (40.5)</td><td>29 (16.8)</td><td>74 (42.8)</td><td>173 (54.4)</td></tr><tr><td>M</td><td>58 (40.0)</td><td>38 (26.2)</td><td>49 (33.8)</td><td>145 (45.6)</td></tr><tr><td colspan="2">Total</td><td>128 (40.3)</td><td>67 (21.1)</td><td>123 (38.7)</td><td>318</td></tr><tr><td rowspan="3">C</td><td rowspan="3">Limbe</td><td rowspan="2">Gender</td><td>F</td><td>75 (50.3)</td><td>39 (26.2)</td><td>35 (23.5)</td><td>149 (46.9)</td></tr><tr><td>M</td><td>103 (61.0)</td><td>39 (23.1)</td><td>27 (15.9)</td><td>169 (53.1)</td></tr><tr><td colspan="2">Total</td><td>178 (56.0)</td><td>78 (24.5)</td><td>62 (19.5)</td><td>318</td></tr><tr><td rowspan="3">SCEF</td><td rowspan="3">Yaounde</td><td rowspan="2">Gender</td><td>F</td><td>61 (40.7)</td><td>32 (21.3)</td><td>57 (38.0)</td><td>150 (44.0)</td></tr><tr><td>M</td><td>100 (52.4)</td><td>46 (24.1)</td><td>45 (23.6)</td><td>191 (56.0)</td></tr><tr><td colspan="2">Total</td><td>161 (47.2)</td><td>78 (22.9)</td><td>102 (29.9)</td><td>341</td></tr><tr><td rowspan="3">SS</td><td rowspan="3">Maroua</td><td rowspan="2">Gender</td><td>F</td><td>122 (74.4)</td><td>27 (16.5)</td><td>15 (9.1)</td><td>164 (52.1)</td></tr><tr><td>M</td><td>111 (73.5)</td><td>27 (17.9)</td><td>13 (8.6)</td><td>151 (47.9)</td></tr><tr><td colspan="2">Total</td><td>233 (74.0)</td><td>54 (17.1)</td><td>28 (8.9)</td><td>315</td></tr><tr><td rowspan="2">HIP</td><td rowspan="2">Ngaoundere</td><td rowspan="2">Gender</td><td>F</td><td>94 (65.7)</td><td>32 (22.4)</td><td>17 (11.9)</td><td>143 (45.1)</td></tr><tr><td>M</td><td>116 (66.7)</td><td>34 (19.5)</td><td>24 (13.8)</td><td>174 (54.9)</td></tr></table>
<table><tr><td rowspan="2">Epidemiological strata</td><td rowspan="2" colspan="3">Study sites</td><td colspan="3">Age (months)</td><td rowspan="2">Total</td></tr><tr><td>< 60</td><td>60–119</td><td>120+</td></tr><tr><td>HIP</td><td>Ngaoundere</td><td colspan="2">Total</td><td>210 (66.3)</td><td>66 (20.8)</td><td>41 (12.9)</td><td>317</td></tr><tr><td rowspan="3" colspan="2">Total</td><td rowspan="2">Gender</td><td>F</td><td>422 (54.2)</td><td>159 (20.4)</td><td>198 (25.4)</td><td>779 (48.4)</td></tr><tr><td>M</td><td>488 (58.8)</td><td>184 (22.2)</td><td>158 (19.0)</td><td>830 (51.6)</td></tr><tr><td colspan="2">Total</td><td>910 (56.6)</td><td>343 (21.3)</td><td>356 (22.1)</td><td>1609</td></tr></table>
ea1acb08fac05707e02814ec3c2f6105f812fbf7827e01359955c64cf011cfb4.png
complex
<table><tr><td></td><td colspan="8">Animal ID</td><td>Total tRFs</td><td>tRFs/cow</td></tr><tr><td>tRF3</td><td>1141</td><td>1143</td><td>2919</td><td>2927</td><td>2931</td><td>2938</td><td>2939</td><td>2942</td><td></td><td></td></tr><tr><td>tRF3-Ala</td><td>1</td><td>0</td><td>1</td><td>2</td><td>1</td><td>0</td><td>0</td><td>0</td><td>5</td><td>0.625</td></tr><tr><td>tRF3-Arg</td><td>1</td><td>4</td><td>4</td><td>10</td><td>1</td><td>7</td><td>2</td><td>4</td><td>33</td><td>4.125</td></tr><tr><td>tRF3-Asn</td><td>13</td><td>6</td><td>18</td><td>8</td><td>3</td><td>6</td><td>14</td><td>6</td><td>74</td><td>9.250</td></tr><tr><td>tRF3-Asp</td><td>6</td><td>3</td><td>9</td><td>6</td><td>3</td><td>3</td><td>6</td><td>4</td><td>40</td><td>5</td></tr><tr><td>tRF3-Cys</td><td>0</td><td>1</td><td>0</td><td>3</td><td>0</td><td>0</td><td>0</td><td>0</td><td>4</td><td>0.500</td></tr><tr><td>tRF3-Gln</td><td>2</td><td>1</td><td>1</td><td>2</td><td>1</td><td>1</td><td>0</td><td>1</td><td>9</td><td>1.125</td></tr><tr><td>tRF3-Glu</td><td>34</td><td>16</td><td>41</td><td>43</td><td>25</td><td>26</td><td>24</td><td>46</td><td>255</td><td>31.875</td></tr><tr><td>tRF3-Gly</td><td>0</td><td>0</td><td>1</td><td>4</td><td>0</td><td>1</td><td>2</td><td>0</td><td>8</td><td>1</td></tr><tr><td>tRF3-His</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td></tr><tr><td>tRF3-Ile</td><td>0</td><td>1</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>1</td><td>0.125</td></tr><tr><td>tRF3-Leu</td><td>1</td><td>0</td><td>0</td><td>0</td><td>1</td><td>0</td><td>2</td><td>2</td><td>6</td><td>0.750</td></tr><tr><td>tRF3-Lys</td><td>4</td><td>2</td><td>7</td><td>2</td><td>0</td><td>5</td><td>4</td><td>12</td><td>36</td><td>4.500</td></tr><tr><td>tRF3-Met</td><td>3</td><td>2</td><td>1</td><td>1</td><td>1</td><td>1</td><td>0</td><td>0</td><td>9</td><td>1.125</td></tr><tr><td>tRF3-Phe</td><td>0</td><td>1</td><td>0</td><td>0</td><td>0</td><td>0</td><td>1</td><td>0</td><td>2</td><td>0.25</td></tr><tr><td>tRF3-Pro</td><td>0</td><td>1</td><td>1</td><td>3</td><td>0</td><td>0</td><td>0</td><td>0</td><td>5</td><td>0.625</td></tr><tr><td>tRF3-Ser</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td></tr><tr><td>tRF3-Stop</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td></tr><tr><td>tRF3-Thr</td><td>1</td><td>0</td><td>3</td><td>7</td><td>1</td><td>3</td><td>2</td><td>1</td><td>18</td><td>2.250</td></tr><tr><td>tRF3-Trp</td><td>2</td><td>0</td><td>1</td><td>0</td><td>1</td><td>0</td><td>1</td><td>0</td><td>5</td><td>0.625</td></tr><tr><td>tRF3-Tyr</td><td>0</td><td>1</td><td>2</td><td>0</td><td>0</td><td>1</td><td>1</td><td>0</td><td>5</td><td>0.625</td></tr><tr><td>tRF3-Val</td><td>6</td><td>2</td><td>5</td><td>16</td><td>3</td><td>7</td><td>2</td><td>6</td><td>47</td><td>5.875</td></tr><tr><td>Total tRF3</td><td>47</td><td>41</td><td>95</td><td>107</td><td>41</td><td>61</td><td>61</td><td>82</td><td>562</td><td></td></tr></table>
<table><tr><td></td><td colspan="8">Animal ID</td><td>Total tRFs</td><td>tRFs/cow</td></tr><tr><td>tRF3</td><td>1141</td><td>1143</td><td>2919</td><td>2927</td><td>2931</td><td>2938</td><td>2939</td><td>2942</td><td></td><td></td></tr><tr><td>tRF3-Ala</td><td>1</td><td>0</td><td>1</td><td>2</td><td>1</td><td>0</td><td>0</td><td>0</td><td>5</td><td>0.625</td></tr><tr><td>tRF3-Arg</td><td>1</td><td>4</td><td>4</td><td>10</td><td>1</td><td>7</td><td>2</td><td>4</td><td>33</td><td>4.125</td></tr><tr><td>tRF3-Asn</td><td>13</td><td>6</td><td>18</td><td>8</td><td>3</td><td>6</td><td>14</td><td>6</td><td>74</td><td>9.250</td></tr><tr><td>tRF3-Asp</td><td>6</td><td>3</td><td>9</td><td>6</td><td>3</td><td>3</td><td>6</td><td>4</td><td>40</td><td>5</td></tr><tr><td>tRF3-Cys</td><td>0</td><td>1</td><td>0</td><td>3</td><td>0</td><td>0</td><td>0</td><td>0</td><td>4</td><td>0.500</td></tr><tr><td>tRF3-Gln</td><td>2</td><td>1</td><td>1</td><td>2</td><td>1</td><td>1</td><td>0</td><td>1</td><td>9</td><td>1.125</td></tr><tr><td>tRF3-Glu</td><td>34</td><td>16</td><td>41</td><td>43</td><td>25</td><td>26</td><td>24</td><td>46</td><td>255</td><td>31.875</td></tr><tr><td>tRF3</td><td></td><td>0</td><td>1</td><td>4</td><td>0</td><td></td><td>2</td><td></td><td>8</td><td></td></tr></table>
<table><tr><td></td><td colspan="8">Animal ID</td><td>Total tRFs</td><td>tRFs/cow</td></tr><tr><td>tRF3</td><td>1141</td><td>1143</td><td>2919</td><td>2927</td><td>2931</td><td>2938</td><td>2939</td><td>2942</td><td></td><td></td></tr><tr><td>-Gly</td><td>0</td><td></td><td></td><td></td><td></td><td>1</td><td></td><td>0</td><td></td><td>1</td></tr><tr><td>tRF3-His</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td></tr><tr><td>tRF3-Ile</td><td>0</td><td>1</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>1</td><td>0.125</td></tr><tr><td>tRF3-Leu</td><td>1</td><td>0</td><td>0</td><td>0</td><td>1</td><td>0</td><td>2</td><td>2</td><td>6</td><td>0.750</td></tr><tr><td>tRF3-Lys</td><td>4</td><td>2</td><td>7</td><td>2</td><td>0</td><td>5</td><td>4</td><td>12</td><td>36</td><td>4.500</td></tr><tr><td>tRF3-Met</td><td>3</td><td>2</td><td>1</td><td>1</td><td>1</td><td>1</td><td>0</td><td>0</td><td>9</td><td>1.125</td></tr><tr><td>tRF3-Phe</td><td>0</td><td>1</td><td>0</td><td>0</td><td>0</td><td>0</td><td>1</td><td>0</td><td>2</td><td>0.25</td></tr><tr><td>tRF3-Pro</td><td>0</td><td>1</td><td>1</td><td>3</td><td>0</td><td>0</td><td>0</td><td>0</td><td>5</td><td>0.625</td></tr><tr><td>tRF3-Ser</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td></tr><tr><td>tRF3-Stop</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td></tr><tr><td>tRF3-Thr</td><td>1</td><td>0</td><td>3</td><td>7</td><td>1</td><td>3</td><td>2</td><td>1</td><td>18</td><td>2.250</td></tr><tr><td>tRF3-Trp</td><td>2</td><td>0</td><td>1</td><td>0</td><td>1</td><td>0</td><td>1</td><td>0</td><td>5</td><td>0.625</td></tr><tr><td>tRF3-Tyr</td><td>0</td><td>1</td><td>2</td><td>0</td><td>0</td><td>1</td><td>1</td><td>0</td><td>5</td><td>0.625</td></tr><tr><td>tRF3-Val</td><td>6</td><td>2</td><td>5</td><td>16</td><td>3</td><td>7</td><td>2</td><td>6</td><td>47</td><td>5.875</td></tr><tr><td>Total tRF3</td><td>47</td><td>41</td><td>95</td><td>107</td><td>41</td><td>61</td><td>61</td><td>82</td><td>562</td><td></td></tr></table>
c54d167d3be89224493bf3c0904bfbdcb5d058455481708dc7e73fc387e5ca8e.png
complex
<table><tr><td rowspan="2">Characteristics</td><td colspan="2">Value</td></tr><tr><td>No.</td><td>%</td></tr><tr><td>Material surrounding the base</td><td></td><td></td></tr><tr><td>Mud</td><td>10</td><td>40</td></tr><tr><td>Brick</td><td>2</td><td>8</td></tr><tr><td>Small amount of cement</td><td>2</td><td>8</td></tr><tr><td>Large cement platform</td><td>11</td><td>44</td></tr><tr><td>Tubewell colour</td><td></td><td></td></tr><tr><td>Natural</td><td>21</td><td>84</td></tr><tr><td>Green</td><td>3</td><td>12</td></tr><tr><td>Red</td><td>1</td><td>4</td></tr><tr><td>Sediment in water</td><td></td><td></td></tr><tr><td>Iron</td><td>0</td><td>0</td></tr><tr><td>Sand</td><td>1</td><td>4</td></tr><tr><td>Iron and sand</td><td>3</td><td>13</td></tr><tr><td>None</td><td>21</td><td>84</td></tr><tr><td>Arsenic present&#8727;</td><td></td><td></td></tr><tr><td>No (&lt;50 &#956;g/L)</td><td>2</td><td>8</td></tr><tr><td>Yes (&#8805;50 &#956;g/L)</td><td>2</td><td>8</td></tr><tr><td>Never tested</td><td>21</td><td>84</td></tr><tr><td></td><td colspan="2">Mean (SD) and range</td></tr><tr><td>Temperature (&#176;C)</td><td colspan="2">26.8 (0.5)</td></tr><tr><td></td><td colspan="2">25.8-28.6</td></tr><tr><td>pH</td><td colspan="2">7.3 (0.3)</td></tr><tr><td></td><td colspan="2">6.5-7.8</td></tr><tr><td></td><td colspan="2">Median (IQR) and range</td></tr><tr><td>Total iron concentration (mg/L)</td><td></td><td></td></tr><tr><td>AAS</td><td colspan="2">11.4 (8.4-15.8)</td></tr><tr><td></td><td colspan="2">0.2-28.0</td></tr><tr><td>Test-kit</td><td colspan="2">12.8 (10.8-18.8)</td></tr><tr><td></td><td colspan="2">0.6-32.0</td></tr><tr><td>Colorimeter</td><td colspan="2">13.60 (9.60-17.60)</td></tr><tr><td></td><td colspan="2">0.50-49.20</td></tr><tr><td>Ferrous iron by colorimeter (mg/L)</td><td colspan="2">6.32 (3.10-10.50)</td></tr><tr><td></td><td colspan="2">0.02-28.60</td></tr></table>
<table><tr><td rowspan="2">Characteristics</td><td colspan="2">Value</td></tr><tr><td>No.</td><td>%</td></tr><tr><td>Material surrounding the base</td><td></td><td></td></tr><tr><td>Mud</td><td>10</td><td>40</td></tr><tr><td>Brick</td><td>2</td><td>8</td></tr><tr><td>Small amount of cement</td><td>2</td><td>8</td></tr><tr><td>Large cement platform</td><td>11</td><td>44</td></tr><tr><td>Tubewell colour</td><td></td><td></td></tr><tr><td>Natural</td><td>21</td><td>84</td></tr><tr><td>Green</td><td>3</td><td>12</td></tr><tr><td>Red</td><td>1</td><td>4</td></tr><tr><td>Sediment in water</td><td></td><td></td></tr><tr><td>Iron</td><td>0</td><td>0</td></tr><tr><td>Sand</td><td>1</td><td>4</td></tr><tr><td>Iron and sand</td><td>3</td><td>13</td></tr><tr><td>None</td><td>21</td><td>84</td></tr><tr><td>Arsenic present∗</td><td></td><td></td></tr><tr><td>No (<50 μg/L)</td><td>2</td><td>8</td></tr><tr><td>Yes (≥50 μg/L)</td><td>2</td><td>8</td></tr><tr><td>Never tested</td><td>21</td><td>84</td></tr><tr><td></td><td colspan="2">Mean (SD) and range</td></tr><tr><td>Temperature (°C)</td><td colspan="2">26.8 (0.5)</td></tr><tr><td></td><td colspan="2">25.8-28.6</td></tr><tr><td>pH</td><td colspan="2">7.3 (0.3)</td></tr><tr><td></td><td colspan="2">6.5-7.8</td></tr><tr><td></td><td colspan="2">Median (IQR) and range</td></tr><tr><td>Total iron concentration (mg/L)</td><td></td><td></td></tr></table>
<table><tr><td rowspan="2">Characteristics</td><td colspan="2">Value</td></tr><tr><td>No.</td><td>%</td></tr><tr><td>AAS</td><td colspan="2">11.4 (8.4-15.8)</td></tr><tr><td></td><td colspan="2">0.2-28.0</td></tr><tr><td>Test-kit</td><td colspan="2">12.8 (10.8-18.8)</td></tr><tr><td></td><td colspan="2">0.6-32.0</td></tr><tr><td>Colorimeter</td><td colspan="2">13.60 (9.60-17.60)</td></tr><tr><td></td><td colspan="2">0.50-49.20</td></tr><tr><td>Ferrous iron by colorimeter (mg/L)</td><td colspan="2">6.32 (3.10-10.50)</td></tr><tr><td></td><td colspan="2">0.02-28.60</td></tr></table>