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image_name stringlengths 68 68	type stringclasses 2 values	gt_table stringlengths 116 12.6k	table_fragment_1 stringlengths 43 8.42k	table_fragment_2 stringlengths 39 8.21k
a5eedfbfa8eb069fd2e0fcdb947decbd313f6affe3b3b04fcd8c402e2459b884.png	complex	<table><tr><td rowspan="2">Urea Concentration (M)</td><td colspan="7">Mn Content (%)</td></tr><tr><td>5</td><td>10</td><td>20</td><td>40</td><td>60</td><td>80</td><td>100</td></tr><tr><td>0.5</td><td>4.59</td><td>1.66</td><td>3.386</td><td>0.896</td><td>3.808</td><td>3.585</td><td>2.488</td></tr><tr><td>1.0</td><td>3.089</td><td>0.685</td><td>2.964</td><td>0.136</td><td>2.739</td><td>1.973</td><td>2.385</td></tr><tr><td>2.0</td><td>2.732</td><td>2.439</td><td>2.135</td><td>0.085</td><td>2.256</td><td>2.244</td><td>2.403</td></tr></table>	<table><tr><td rowspan="2">Urea Concentration (M)</td><td colspan="3">Mn Content (%)</td></tr><tr><td>5</td><td>10</td><td>20</td></tr><tr><td>0.5</td><td>4.59</td><td>1.66</td><td>3.386</td></tr><tr><td>1.0</td><td>3.089</td><td>0.685</td><td>2.964</td></tr><tr><td>2.0</td><td>2.732</td><td>2.439</td><td>2.135</td></tr></table>	<table><tr><td colspan="4">Mn Content (%)</td></tr><tr><td>40</td><td>60</td><td>80</td><td>100</td></tr><tr><td>0.896</td><td>3.808</td><td>3.585</td><td>2.488</td></tr><tr><td>0.136</td><td>2.739</td><td>1.973</td><td>2.385</td></tr><tr><td>0.085</td><td>2.256</td><td>2.244</td><td>2.403</td></tr></table>
ffbaff2cfee3c3bc840fdae42cf3396502ec0136d0c1f835a83051a6603f277b.png	complex	<table><tr><td>Clinical Features</td><td colspan="2">MBD5-specific mutation<sup>20,22–24</sup></td><td colspan="2">2q23.1 Deletion<sup>20,22–24</sup></td><td>Case in this study</td></tr><tr><td> </td><td>Number</td><td>Percentage</td><td>Number</td><td>Percentage</td><td>+, present; - absent</td></tr><tr><td>Neurological</td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td> Development delay</td><td>20/21</td><td>95%</td><td>53/55</td><td>96%</td><td>+</td></tr><tr><td> Language impairment</td><td>12/21</td><td>57%</td><td>38/55</td><td>69%</td><td>+</td></tr><tr><td> Seizure</td><td>11/21</td><td>52%</td><td>32/55</td><td>58%</td><td>+</td></tr><tr><td> Infantile spasms</td><td>0/21</td><td>0</td><td>0/55</td><td>0</td><td>+</td></tr><tr><td> Infantile hypotonia</td><td>4/21</td><td>19%</td><td>23/55</td><td>41%</td><td>+</td></tr><tr><td>Growth/Endocrine</td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td> Short stature</td><td>5/21</td><td>24%</td><td>25/55</td><td>45%</td><td>-</td></tr><tr><td> Local hirsutism</td><td>0/21</td><td>0</td><td>4/55</td><td>7%</td><td>-</td></tr><tr><td>Craniofacial abnormalities</td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td> Coarse face</td><td>0/21</td><td>0</td><td>3/55</td><td>5%</td><td>+</td></tr><tr><td> Broad forehead</td><td>3/21</td><td>14%</td><td>4/55</td><td>7%</td><td>+</td></tr><tr><td> Microcephaly</td><td>1/21</td><td>5%</td><td>26/55</td><td>47%</td><td>+(<2SD)</td></tr><tr><td> Synophrys</td><td>2/21</td><td>9%</td><td>10/55</td><td>18%</td><td>+mild</td></tr><tr><td> Nasal abnormalities</td><td>7/21</td><td>33%</td><td>35/55</td><td>64%</td><td>+</td></tr><tr><td> Open mouth</td><td>3/21</td><td>14%</td><td>23/55</td><td>42%</td><td>+</td></tr><tr><td> Downturned corners of the mouth</td><td>3/21</td><td>14%</td><td>17/55</td><td>31%</td><td>+</td></tr><tr><td> Macroglossia or protruding tongue</td><td>2/21</td><td>9%</td><td>6/55</td><td>11%</td><td>-</td></tr><tr><td> Dental abnormalities</td><td>4/21</td><td>19%</td><td>13/55</td><td>24%</td><td> </td></tr><tr><td>Skeletal abnormalities</td><td> </td><td> </td><td> </td><td> </td><td>+</td></tr><tr><td> Small hands and feet</td><td>1/21</td><td>5%</td><td>23/55</td><td>42%</td><td>+</td></tr><tr><td> Clinodactyly, 5th finger</td><td>2/21</td><td>9%</td><td>22/55</td><td>40%</td><td>+</td></tr><tr><td> Brachydactyly</td><td>0/21</td><td>0</td><td>13/55</td><td>24%</td><td>+</td></tr><tr><td> Short fifth digit of hands/feet</td><td>1/21</td><td>5%</td><td>14/55</td><td>25%</td><td>+</td></tr><tr><td> Absent hallux</td><td>0/21</td><td>0</td><td>0/55</td><td>0</td><td>+</td></tr><tr><td>Behaviors</td><td> </td><td> </td><td> </td><td> </td><td>-</td></tr><tr><td> Autistic feature</td><td>13/21</td><td>62%</td><td>44/55</td><td>80%</td><td>+</td></tr><tr><td> Sleep disturbance</td><td>5/21</td><td>24%</td><td>17/55</td><td>31%</td><td>ND</td></tr><tr><td> Self-injurious behavior</td><td>2/21</td><td>9%</td><td>17/55</td><td>31%</td><td>+</td></tr><tr><td>Other</td><td> </td><td> </td><td> </td><td> </td><td>-</td></tr><tr><td> Cardiovascular abnormalities</td><td>1/21</td><td>5%</td><td>4/55</td><td>7%</td><td>-</td></tr><tr><td> Urogenital abnormalities</td><td>1/21</td><td>45%</td><td>1/55</td><td>2%</td><td>-</td></tr></table>	<table><tr><td>Clinical Features</td><td colspan="2">MBD5-specific mutation20,22–24</td><td colspan="2">2q23.1 Deletion20,22–24</td><td>Case in this study</td></tr><tr><td></td><td>Number</td><td>Percentage</td><td>Number</td><td>Percentage</td><td>+, present; - absent</td></tr><tr><td>Neurological</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Development delay</td><td>20/21</td><td>95%</td><td>53/55</td><td>96%</td><td>+</td></tr><tr><td>Language impairment</td><td>12/21</td><td>57%</td><td>38/55</td><td>69%</td><td>+</td></tr><tr><td>Seizure</td><td>11/21</td><td>52%</td><td>32/55</td><td>58%</td><td>+</td></tr><tr><td>Infantile spasms</td><td>0/21</td><td>0</td><td>0/55</td><td>0</td><td>+</td></tr><tr><td>Infantile hypotonia</td><td>4/21</td><td>19%</td><td>23/55</td><td>41%</td><td>+</td></tr><tr><td>Growth/Endocrine</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Short stature</td><td>5/21</td><td>24%</td><td>25/55</td><td>45%</td><td>-</td></tr><tr><td>Local hirsutism</td><td>0/21</td><td>0</td><td>4/55</td><td>7%</td><td>-</td></tr><tr><td>Craniofacial abnormalities</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Coarse face</td><td>0/21</td><td>0</td><td>3/55</td><td>5%</td><td>+</td></tr><tr><td>Broad forehead</td><td>3/21</td><td>14%</td><td>4/55</td><td>7%</td><td>+</td></tr><tr><td>Microcephaly</td><td>1/21</td><td>5%</td><td>26/55</td><td>47%</td><td>+(<2SD)</td></tr><tr><td>Synophrys</td><td>2/21</td><td>9%</td><td>10/55</td><td>18%</td><td>+mild</td></tr><tr><td>Nasal abnormalities</td><td>7/21</td><td>33%</td><td>35/55</td><td>64%</td><td>+</td></tr><tr><td>Open mouth</td><td>3/21</td><td>14%</td><td>23/55</td><td>42%</td><td>+</td></tr><tr><td>Downturned corners of the mouth</td><td>3/21</td><td>14%</td><td>17/55</td><td>31%</td><td>+</td></tr><tr><td>Macroglossia or protruding tongue</td><td>2/21</td><td>9%</td><td>6/55</td><td>11%</td><td>-</td></tr><tr><td>Dental abnormalities</td><td>4/21</td><td>19%</td><td>13/55</td><td>24%</td><td></td></tr><tr><td>Skeletal abnormalities</td><td></td><td></td><td></td><td></td><td>+</td></tr><tr><td>Small hands and feet</td><td>1/21</td><td>5%</td><td>23/55</td><td>42%</td><td>+</td></tr></table>	<table><tr><td>Clinical Features</td><td colspan="2">MBD5-specific mutation20,22–24</td><td colspan="2">2q23.1 Deletion20,22–24</td><td>Case in this study</td></tr><tr><td></td><td>Number</td><td>Percentage</td><td>Number</td><td>Percentage</td><td>+, present; - absent</td></tr><tr><td>Clinodactyly, 5th finger</td><td>2/21</td><td>9%</td><td>22/55</td><td>40%</td><td>+</td></tr><tr><td>Brachydactyly</td><td>0/21</td><td>0</td><td>13/55</td><td>24%</td><td>+</td></tr><tr><td>Short fifth digit of hands/feet</td><td>1/21</td><td>5%</td><td>14/55</td><td>25%</td><td>+</td></tr><tr><td>Absent hallux</td><td>0/21</td><td>0</td><td>0/55</td><td>0</td><td>+</td></tr><tr><td>Behaviors</td><td></td><td></td><td></td><td></td><td>-</td></tr><tr><td>Autistic feature</td><td>13/21</td><td>62%</td><td>44/55</td><td>80%</td><td>+</td></tr><tr><td>Sleep disturbance</td><td>5/21</td><td>24%</td><td>17/55</td><td>31%</td><td>ND</td></tr><tr><td>Self-injurious behavior</td><td>2/21</td><td>9%</td><td>17/55</td><td>31%</td><td>+</td></tr><tr><td>Other</td><td></td><td></td><td></td><td></td><td>-</td></tr><tr><td>Cardiovascular abnormalities</td><td>1/21</td><td>5%</td><td>4/55</td><td>7%</td><td>-</td></tr><tr><td>Urogenital abnormalities</td><td>1/21</td><td>45%</td><td>1/55</td><td>2%</td><td>-</td></tr></table>
679f06a83ff804a214dbbba312728a1730063003fc58b59cb2f4e7cbb2d4a71d.png	complex	<table><tr><td></td><td colspan="3">Dementia can be cured through divine healing, such as through prayer</td><td colspan="3">People with dementia should be placed in ‘homes’</td></tr><tr><td></td><td><i>B</i></td><td>β</td><td><i>t</i></td><td><i>B</i></td><td>β</td><td><i>t</i></td></tr><tr><td>Age</td><td>0.013</td><td>0.013</td><td>0.333</td><td>0.134</td><td>0.141</td><td>3.495*</td></tr><tr><td>Gender</td><td>−0.029</td><td>−0.012</td><td>−0.377</td><td>−0.024</td><td>−0.011</td><td>−0.328</td></tr><tr><td>Ethnic</td><td>0.069</td><td>0.051</td><td>1.546</td><td>0.022</td><td>0.018</td><td>0.520</td></tr><tr><td>Religion</td><td>−0.057</td><td>−0.286</td><td>−8.938</td><td>−0.002</td><td>−0.012</td><td>−0.377</td></tr><tr><td>Education</td><td>0.034</td><td>0.063</td><td>1.610</td><td>−0.029</td><td>−0.058</td><td>−1.427</td></tr><tr><td></td><td colspan="2">Multiple R=0.301</td><td></td><td colspan="2">Multiple R=0.186</td><td></td></tr><tr><td></td><td colspan="2">R<sup>2</sup>=0.091</td><td></td><td colspan="2">R<sup>2</sup>=0.034</td><td></td></tr><tr><td></td><td colspan="3">Adjusted R square=0.086</td><td colspan="3">Adjusted R square=0.029</td></tr><tr><td></td><td colspan="2">F=18.810</td><td></td><td colspan="2">F=6.730*</td><td></td></tr></table>	<table><tr><td></td><td colspan="3">Dementia can be cured through divine healing, such as through prayer</td><td colspan="3">People with dementia should be placed in ‘homes’</td></tr><tr><td></td><td>B</td><td>β</td><td>t</td><td>B</td><td>β</td><td>t</td></tr><tr><td>Age</td><td>0.013</td><td>0.013</td><td>0.333</td><td>0.134</td><td>0.141</td><td>3.495*</td></tr><tr><td>Gender</td><td>−0.029</td><td>−0.012</td><td>−0.377</td><td>−0.024</td><td>−0.011</td><td>−0.328</td></tr><tr><td>Ethnic</td><td>0.069</td><td>0.051</td><td>1.546</td><td>0.022</td><td>0.018</td><td>0.520</td></tr><tr><td>Religion</td><td>−0.057</td><td>−0.286</td><td>−8.938*</td><td>−0.002</td><td>−0.012</td><td>−0.377</td></tr><tr><td>Education</td><td>0.034</td><td>0.063</td><td>1.610</td><td>−0.029</td><td>−0.058</td><td>−1.427</td></tr><tr><td></td><td colspan="2">Multiple R=0.301</td><td></td><td colspan="2">Multiple R=0.186</td><td></td></tr></table>	<table><tr><td></td><td colspan="2">R2=0.091</td><td></td><td colspan="2">R2=0.034</td><td></td></tr><tr><td></td><td colspan="3">Adjusted R square=0.086</td><td colspan="3">Adjusted R square=0.029</td></tr><tr><td></td><td colspan="2">F=18.810*</td><td></td><td colspan="2">F=6.730*</td><td></td></tr></table>
09b3ace1d198fa113b5a51f8ad5b06ae2576c63fc9c692ab09fb2bcbef7032e9.png	complex	<table><tr><td></td><td colspan="5">Domains of quality of life <sup>d</sup></td></tr><tr><td>Characteristics</td><td>Physical Mean (SD)</td><td>Psychological Mean (SD)</td><td>Social Mean (SD)</td><td>Environmental Mean (SD)</td><td>Global Mean (SD)</td></tr><tr><td>Diagnosis</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> Stroke</td><td>41.26 (15.49)*</td><td>40.47 (15.31)</td><td>51.04 (17.37)</td><td>46.04 (17.41)</td><td>45.2 (23.14)</td></tr><tr><td> Non-stroke</td><td>67.45 (15.69)</td><td>64.76 (17.19)</td><td>71.25 (15.03)</td><td>61.71 (15.26)</td><td>65.46 (18.58)</td></tr><tr><td>Gender</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> Male</td><td>61.99 (19.38)</td><td>61.09 (19.97)</td><td>68.15 (17.98)</td><td>60.35 (17.86)</td><td>62.36 (21.51)</td></tr><tr><td> Female</td><td>55.25 (19.95)</td><td>51.9 (19.28)</td><td>60.59 (18.25)</td><td>52.33 (16.41)</td><td>54.78 (22.60)</td></tr><tr><td>Education <sup>a</sup></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> Low</td><td>54.84 (19.31)</td><td>53.24 (18.50)</td><td>61.87 (17.66)</td><td>52.59 (16.18)</td><td>55.45 (21.83)</td></tr><tr><td> High</td><td>68.93 (17.83)</td><td>65.59 (21.56)</td><td>71.42 (18.85)</td><td>66.63 (17.25)</td><td>67.20 (21.49)</td></tr><tr><td>Income <sup>b</sup></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> Low</td><td>54.46 (18.45)</td><td>51.15 (19.01)</td><td>61.41 (17.61)</td><td>51.20 (16.43)</td><td>54.78 (22.02)</td></tr><tr><td> High</td><td>62.15 (20.42)</td><td>61.05 (19.98)</td><td>66.98 (18.82)</td><td>60.69 (17.43)</td><td>61.83 (22.14)</td></tr><tr><td>Psychological stress <sup>c</sup></td><td>-0.339 </td><td>-0.247 </td><td>-0.231 </td><td>-0.245 </td><td>-0.284 **</td></tr></table>	<table><tr><td></td><td colspan="5">Domains of quality of life d</td></tr><tr><td>Characteristics</td><td>Physical Mean (SD)</td><td>Psychological Mean (SD)</td><td>Social Mean (SD)</td><td>Environmental Mean (SD)</td><td>Global Mean (SD)</td></tr><tr><td>Diagnosis</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Stroke</td><td>41.26 (15.49)*</td><td>40.47 (15.31)</td><td>51.04 (17.37)</td><td>46.04 (17.41)</td><td>45.2 (23.14)</td></tr><tr><td>Non-stroke</td><td>67.45 (15.69)</td><td>64.76 (17.19)</td><td>71.25 (15.03)</td><td>61.71 (15.26)</td><td>65.46 (18.58)</td></tr><tr><td>Gender</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Male</td><td>61.99 (19.38)</td><td>61.09 (19.97)</td><td>68.15 (17.98)</td><td>60.35 (17.86)</td><td>62.36 (21.51)*</td></tr></table>	<table><tr><td>Female</td><td>55.25 (19.95)</td><td>51.9 (19.28)</td><td>60.59 (18.25)</td><td>52.33 (16.41)</td><td>54.78 (22.60)</td></tr><tr><td>Education a</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Low</td><td>54.84 (19.31)*</td><td>53.24 (18.50)</td><td>61.87 (17.66)</td><td>52.59 (16.18)</td><td>55.45 (21.83)</td></tr><tr><td>High</td><td>68.93 (17.83)</td><td>65.59 (21.56)</td><td>71.42 (18.85)</td><td>66.63 (17.25)</td><td>67.20 (21.49)</td></tr><tr><td>Income b</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Low</td><td>54.46 (18.45)</td><td>51.15 (19.01)</td><td>61.41 (17.61)</td><td>51.20 (16.43)</td><td>54.78 (22.02)</td></tr><tr><td>High</td><td>62.15 (20.42)</td><td>61.05 (19.98)</td><td>66.98 (18.82)</td><td>60.69 (17.43)</td><td>61.83 (22.14)</td></tr><tr><td>Psychological stress c</td><td>-0.339 </td><td>-0.247 </td><td>-0.231 </td><td>-0.245 </td><td>-0.284 **</td></tr></table>
f3964f6a2426fcfc2472ed4a0d3ba993082709aa88fa388f3f8fbed4c5b126ba.png	simple	<table><tr><td></td><td>No cancer</td><td>Cancer</td><td>Total</td></tr><tr><td>Mammogram (+)</td><td>20</td><td>10</td><td>32</td></tr><tr><td>Mammogram (−)</td><td>21</td><td>1</td><td>21</td></tr><tr><td>Total</td><td>41</td><td>11</td><td>52</td></tr><tr><td>Measure</td><td>Sn = 91 %</td><td>Sp = 51 %</td><td></td></tr></table>	<table><tr><td></td><td>No cancer</td><td>Cancer</td><td>Total</td></tr><tr><td>Mammogram (+)</td><td>20</td><td>10</td><td>32</td></tr><tr><td>Mammogram (−)</td><td>21</td><td>1</td><td>21</td></tr></table>	<table><tr><td>Total</td><td>41</td><td>11</td><td>52</td></tr><tr><td>Measure</td><td>Sn = 91 %</td><td>Sp = 51 %</td><td></td></tr></table>
068d59979b22ae62902570af3c8c6b3edac99fc0d20bdd3dd8c558651b8482ea.png	complex	<table><tr><td colspan="8">HtMM</td></tr><tr><td colspan="8">Normalized jerk</td></tr><tr><td colspan="4">Dominant</td><td colspan="4">Nondominant</td></tr><tr><td>Young adults</td><td>Middle aged</td><td>Senior</td><td>All</td><td>Young adults</td><td>Middle aged</td><td>Senior</td><td>All</td></tr><tr><td><i>R</i> = 0.75<i>p</i> < 10<sup>–6</sup></td><td><i>R</i> = 0.84<i>p</i> < 10<sup>–5</sup></td><td><i>R</i> = 0.79<i>p</i> < 10<sup>–5</sup></td><td><i>R</i> = 0.80<i>p</i> < 10<sup>–17</sup></td><td><i>R</i> = 0.75<i>p</i> < 10<sup>–6</sup></td><td><i>R</i> = 0.65<i>p</i> = 0.002</td><td><i>R</i> = 0.67<i>p</i> < 10<sup>–3</sup></td><td><i>R</i> = 0.71<i>p</i> < 10<sup>–12</sup></td></tr><tr><td colspan="8">Acceleration coefficient of periodicity</td></tr><tr><td colspan="4">Dominant</td><td colspan="4">Nondominant</td></tr><tr><td>Young adults</td><td>Middle aged</td><td>Senior</td><td>All</td><td>Young adults</td><td>Middle aged</td><td>Senior</td><td>All</td></tr><tr><td><i>R</i> = −0.43<i>p</i> = 0.010</td><td><i>R</i> = −0.63<i>p</i> = 0.004</td><td><i>R</i> = −0.66<i>p</i> < 10<sup>–3</sup></td><td><i>R</i> = −0.61<i>p</i> < 10<sup>–8</sup></td><td><i>R</i> = −0.61<i>p</i> < 10<sup>–3</sup></td><td><i>R</i> = −0.36<i>p</i> = 0.135</td><td><i>R</i> = −0.47<i>p</i> = 0.022</td><td><i>R</i> = −0.51<i>p</i> < 10<sup>–5</sup></td></tr></table>	<table><tr><td colspan="8">HtMM</td></tr><tr><td colspan="8">Normalized jerk</td></tr><tr><td colspan="4">Dominant</td><td colspan="4">Nondominant</td></tr><tr><td>Young adults</td><td>Middle aged</td><td>Senior</td><td>All</td><td>Young adults</td><td>Middle aged</td><td>Senior</td><td>All</td></tr><tr><td>R = 0.75p < 10–6</td><td>R = 0.84p < 10–5</td><td>R = 0.79p < 10–5</td><td>R = 0.80p < 10–17</td><td>R = 0.75p < 10–6</td><td>R = 0.65p = 0.002</td><td>R = 0.67p < 10–3</td><td>R = 0.71p < 10–12</td></tr><tr><td colspan="8">Acceleration coefficient of periodicity</td></tr></table>	<table><tr><td colspan="8">HtMM</td></tr><tr><td colspan="4">Dominant</td><td colspan="4">Nondominant</td></tr><tr><td>Young adults</td><td>Middle aged</td><td>Senior</td><td>All</td><td>Young adults</td><td>Middle aged</td><td>Senior</td><td>All</td></tr><tr><td>R = −0.43p = 0.010</td><td>R = −0.63p = 0.004</td><td>R = −0.66p < 10–3</td><td>R = −0.61p < 10–8</td><td>R = −0.61p < 10–3</td><td>R = −0.36p = 0.135</td><td>R = −0.47p = 0.022</td><td>R = −0.51p < 10–5</td></tr></table>
afc89447d928941bfeee5482cecbf3f03e949cdb4abc00b7b9660b8f5580223a.png	complex	<table><tr><td>Group</td><td>Ace genotype</td><td>Presence</td><td>Absence</td><td>Total</td><td>X<sup>2</sup></td><td>p</td><td>X<sup>2</sup></td><td>p</td><td>OR (CI 5-95%)</td></tr><tr><td rowspan="3">Without taking <i>CFTR</i> mutation into account</td><td>I/I</td><td>8</td><td>64</td><td>72</td><td rowspan="3">8.654</td><td rowspan="3">0.013</td><td>0.468</td><td>0.498</td><td>0.699 (0.319 – 1.534)</td></tr><tr><td>I/D</td><td>9</td><td>74</td><td>82</td><td>0.814</td><td>0.182</td><td>0.651 (0.304 – 1.394)</td></tr><tr><td>D/D</td><td>8</td><td>16</td><td>24</td><td>8,653</td><td>0.003</td><td>4.509 (1.513 – 10.89)</td></tr><tr><td rowspan="3">No identified <i>CFTR</i> mutation</td><td>I/I</td><td>3</td><td>18</td><td>21</td><td rowspan="3">0.530</td><td rowspan="3">0.767</td><td>0.003</td><td>1.29</td><td>1.056 (0.188 - 5.925)</td></tr><tr><td>I/D</td><td>2</td><td>16</td><td>18</td><td>0.204</td><td>1.00</td><td>0.656 (0.107 - 4.041)</td></tr><tr><td>D/D</td><td>1</td><td>3</td><td>4</td><td>0.438</td><td>0.93</td><td>2.267 (0.196 - 26.27)</td></tr><tr><td rowspan="3">One <i>CFTR</i> mutation identified class I, II or III</td><td>I/I</td><td>2</td><td>20</td><td>22</td><td rowspan="3">5.539</td><td rowspan="3">0.063</td><td>1.248</td><td>0.466</td><td>0.383 (0.069 - 2.117)</td></tr><tr><td>I/D</td><td>2</td><td>18</td><td>20</td><td>0.787</td><td>0.629</td><td>0.463 (0.084 - 2.562)</td></tr><tr><td>D/D</td><td>4</td><td>5</td><td>9</td><td>6.834</td><td>0.027</td><td>7.6 (1.43 - 40.38)</td></tr><tr><td rowspan="3">Two <i>CFTR</i> mutation identified class I, II or III</td><td>I/I</td><td>3</td><td>26</td><td>29</td><td rowspan="3">0.511</td><td rowspan="3">0.774</td><td>0.084</td><td>1.07</td><td>0.8077 (0.193 - 3.387)</td></tr><tr><td>I/D</td><td>5</td><td>40</td><td>45</td><td>0.039</td><td>1.10</td><td>0.875 (0.234 - 3.275)</td></tr><tr><td>D/D</td><td>2</td><td>9</td><td>11</td><td>0.495</td><td>0.764</td><td>1.833 (0.335 - 10.02)</td></tr></table>	<table><tr><td>Group</td><td>Ace genotype</td><td>Presence</td><td>Absence</td><td>Total</td><td>X2</td><td>p</td><td>X2</td><td>p</td><td>OR (CI 5-95%)</td></tr><tr><td rowspan="3">Without taking CFTR mutation into account</td><td>I/I</td><td>8</td><td>64</td><td>72</td><td rowspan="3">8.654</td><td rowspan="3">0.013</td><td>0.468</td><td>0.498</td><td>0.699 (0.319 – 1.534)</td></tr><tr><td>I/D</td><td>9</td><td>74</td><td>82</td><td>0.814</td><td>0.182</td><td>0.651 (0.304 – 1.394)</td></tr><tr><td>D/D</td><td>8</td><td>16</td><td>24</td><td>8,653</td><td>0.003</td><td>4.509 (1.513 – 10.89)</td></tr><tr><td>No identified CFTR mutation</td><td>I/I</td><td>3</td><td>18</td><td>21</td><td>0.530</td><td>0.767</td><td>0.003</td><td>1.29</td><td>1.056 (0.188 - 5.925)</td></tr></table>	<table><tr><td rowspan="2">No identified CFTR mutation</td><td>I/D</td><td>2</td><td>16</td><td>18</td><td rowspan="2">0.530</td><td rowspan="2">0.767</td><td>0.204</td><td>1.00</td><td>0.656 (0.107 - 4.041)</td></tr><tr><td>D/D</td><td>1</td><td>3</td><td>4</td><td>0.438</td><td>0.93</td><td>2.267 (0.196 - 26.27)</td></tr><tr><td rowspan="3">One CFTR mutation identified class I, II or III</td><td>I/I</td><td>2</td><td>20</td><td>22</td><td rowspan="3">5.539</td><td rowspan="3">0.063</td><td>1.248</td><td>0.466</td><td>0.383 (0.069 - 2.117)</td></tr><tr><td>I/D</td><td>2</td><td>18</td><td>20</td><td>0.787</td><td>0.629</td><td>0.463 (0.084 - 2.562)</td></tr><tr><td>D/D</td><td>4</td><td>5</td><td>9</td><td>6.834</td><td>0.027</td><td>7.6 (1.43 - 40.38)</td></tr><tr><td rowspan="3">Two CFTR mutation identified class I, II or III</td><td>I/I</td><td>3</td><td>26</td><td>29</td><td rowspan="3">0.511</td><td rowspan="3">0.774</td><td>0.084</td><td>1.07</td><td>0.8077 (0.193 - 3.387)</td></tr><tr><td>I/D</td><td>5</td><td>40</td><td>45</td><td>0.039</td><td>1.10</td><td>0.875 (0.234 - 3.275)</td></tr><tr><td>D/D</td><td>2</td><td>9</td><td>11</td><td>0.495</td><td>0.764</td><td>1.833 (0.335 - 10.02)</td></tr></table>
7ba2d83e38f75961abc498dd6749224fd2512970b2db0fb9325481698ff5817f.png	complex	<table><tr><td rowspan="2"><i>Diabetes</i></td><td rowspan="2"><i>Gender</i></td><td rowspan="2"><i>n</i></td><td colspan="3"><i>Box-counting FD (GrayScale)</i></td></tr><tr><td>Mean FD</td><td>95% CI</td><td><i>p</i><sup>†</sup></td></tr><tr><td rowspan="2">No</td><td>Female</td><td>71</td><td>2.4203</td><td>2.4164 - 2.4242</td><td rowspan="4">0.052</td></tr><tr><td>Male</td><td>95</td><td>2.4251</td><td>2.4217 - 2.4284</td></tr><tr><td rowspan="2">Yes</td><td>Female</td><td>12</td><td>2.4308</td><td>2.4214 - 2.4402</td></tr><tr><td>Male</td><td>11</td><td>2.4499</td><td>2.4401 - 2.4598</td></tr></table>	<table><tr><td rowspan="2">Diabetes</td><td rowspan="2">Gender</td><td rowspan="2">n</td><td colspan="3">Box-counting FD (GrayScale)</td></tr><tr><td>Mean FD</td><td>95% CI</td><td>p†</td></tr><tr><td rowspan="2"></td><td>Female</td><td>71</td><td>2.4203</td><td>2.4164 - 2.4242</td><td rowspan="2"></td></tr><tr><td>M</td><td>9</td><td></td><td>2.</td></tr></table>	<table><tr><td>No</td><td>ale</td><td>5</td><td>2.4251</td><td>4217 - 2.4284</td><td rowspan="3">0.052</td></tr><tr><td rowspan="2">Yes</td><td>Female</td><td>12</td><td>2.4308</td><td>2.4214 - 2.4402</td></tr><tr><td>Male</td><td>11</td><td>2.4499</td><td>2.4401 - 2.4598</td></tr></table>
f352d392710200946c50e1af4e88caf6158786301e0171e21b391e297aa66e22.png	simple	<table><tr><td> </td><td>CHD group (<i>n</i> = 45)</td><td>Healthy group (<i>n</i> = 15)</td><td><i>P</i> value</td></tr><tr><td>Age</td><td>59.24 ± 7.87</td><td>57.53 ± 4.47</td><td>0.304</td></tr><tr><td>Gender (male/female)</td><td>33/12</td><td>7/8</td><td>0.058</td></tr></table>	<table><tr><td></td><td>CHD group (n = 45)</td><td>Healthy group (n = 15)</td><td>P value</td></tr></table>	<table><tr><td>Age</td><td>59.24 ± 7.87</td><td>57.53 ± 4.47</td><td>0.304</td></tr><tr><td>Gender (male/female)</td><td>33/12</td><td>7/8</td><td>0.058</td></tr></table>
1303fff38894a702373f96796dec19b28af722ab59ff59afe9532cc4719ee88f.png	complex	<table><tr><td>Predictor</td><td colspan="4">Digit span backward</td><td colspan="4">Letter-number sequencing</td></tr><tr><td></td><td>Df</td><td><i>F</i>-value</td><td><i>p</i>-value</td><td>η<sup>2</sup><sub><i>p</i></sub></td><td>Df</td><td><i>F</i>-value</td><td><i>p</i>-value</td><td>η<sup>2</sup><sub><i>p</i></sub></td></tr><tr><td>Group</td><td>1</td><td>0.56</td><td>0.46</td><td>0.11</td><td>1</td><td>0.64</td><td>0.43</td><td>0.10</td></tr><tr><td>Score</td><td>1</td><td>3.45</td><td>0.07</td><td>0.15</td><td>1</td><td>7.55</td><td>0.01</td><td>0.04</td></tr><tr><td>Group X Score</td><td>1</td><td>0.10</td><td>0.75</td><td>0.00</td><td>1</td><td>0.82</td><td>0.37</td><td>0.00</td></tr><tr><td>Residuals</td><td>33</td><td></td><td></td><td></td><td>33</td><td></td><td></td><td></td></tr></table>	<table><tr><td>Predictor</td><td colspan="4">Digit span backward</td><td colspan="4">Letter-number sequencing</td></tr><tr><td></td><td></td><td>F-</td><td>p-value</td><td>η</td><td>D</td><td>F-va</td><td>p</td><td>η2p</td></tr></table>	<table><tr><td></td><td>Df</td><td>value</td><td></td><td>2p</td><td>f</td><td>lue</td><td>-value</td><td></td></tr><tr><td>Group</td><td>1</td><td>0.56</td><td>0.46</td><td>0.11</td><td>1</td><td>0.64</td><td>0.43</td><td>0.10</td></tr><tr><td>Score</td><td>1</td><td>3.45</td><td>0.07</td><td>0.15</td><td>1</td><td>7.55</td><td>0.01</td><td>0.04</td></tr><tr><td>Group X Score</td><td>1</td><td>0.10</td><td>0.75</td><td>0.00</td><td>1</td><td>0.82</td><td>0.37</td><td>0.00</td></tr><tr><td>Residuals</td><td>33</td><td></td><td></td><td></td><td>33</td><td></td><td></td><td></td></tr></table>
f30ae562cf6fb8777c4018602d19e224fbf0e38fedfbed4757a3564ccf429a66.png	complex	<table><tr><td></td><td colspan="3">No FamPlex</td><td colspan="3">With FamPlex</td></tr><tr><td>Rank</td><td>Entity Text</td><td>Count</td><td>% of Total</td><td>Entity Text</td><td>Count</td><td>% of Total</td></tr><tr><td>1</td><td>NF-kappaB</td><td>18,381</td><td>3.78</td><td>PKCzeta</td><td>222</td><td>0.24</td></tr><tr><td>2</td><td>ERK1/2</td><td>6137</td><td>1.26</td><td>RANTES</td><td>176</td><td>0.19</td></tr><tr><td>3</td><td>mTORC1</td><td>2753</td><td>0.57</td><td>DC</td><td>169</td><td>0.18</td></tr><tr><td>4</td><td>NFkappaB</td><td>2425</td><td>0.50</td><td>LDL</td><td>168</td><td>0.18</td></tr><tr><td>5</td><td>c-Jun</td><td>2369</td><td>0.49</td><td>IgE</td><td>152</td><td>0.17</td></tr><tr><td>6</td><td>antigen</td><td>1724</td><td>0.35</td><td>SDF-1-alpha</td><td>141</td><td>0.15</td></tr><tr><td>7</td><td>PDGF</td><td>1626</td><td>0.33</td><td>receptor</td><td>128</td><td>0.14</td></tr><tr><td>8</td><td>IKK</td><td>1542</td><td>0.32</td><td>beta1 integrin</td><td>127</td><td>0.14</td></tr><tr><td>9</td><td>c-Src</td><td>1362</td><td>0.28</td><td>p38alpha</td><td>126</td><td>0.14</td></tr><tr><td>10</td><td>histone H3</td><td>1347</td><td>0.28</td><td>CD4+</td><td>124</td><td>0.14</td></tr></table>	<table><tr><td></td><td colspan="3">No FamPlex</td><td colspan="3">With FamPlex</td></tr><tr><td>Rank</td><td>Entity Text</td><td>Count</td><td>% of Total</td><td>Entity Text</td><td>Count</td><td>% of Total</td></tr><tr><td>1</td><td>NF-kappaB</td><td>18,381</td><td>3.78</td><td>PKCzeta</td><td>222</td><td>0.24</td></tr><tr><td>2</td><td>ERK1/2</td><td>6137</td><td>1.26</td><td>RANTES</td><td>176</td><td>0.19</td></tr><tr><td>3</td><td>mTORC1</td><td>2753</td><td>0.57</td><td>DC</td><td>169</td><td>0.18</td></tr><tr><td>4</td><td>NFkappaB</td><td>2425</td><td>0.50</td><td>LDL</td><td>168</td><td>0.18</td></tr><tr><td>5</td><td>c-Jun</td><td>2369</td><td>0.49</td><td>IgE</td><td>152</td><td>0.17</td></tr><tr><td>6</td><td>antigen</td><td>1724</td><td>0.35</td><td>SDF-1-alpha</td><td>141</td><td>0.15</td></tr><tr><td>7</td><td>PDGF</td><td>1626</td><td>0.33</td><td>receptor</td><td>128</td><td>0.14</td></tr><tr><td></td><td>IKK</td><td>15</td><td>0</td><td>beta1 </td><td>12</td><td>0.</td></tr></table>	<table><tr><td>8</td><td></td><td>42</td><td>.32</td><td>integrin</td><td>7</td><td>14</td></tr><tr><td>9</td><td>c-Src</td><td>1362</td><td>0.28</td><td>p38alpha</td><td>126</td><td>0.14</td></tr><tr><td>10</td><td>histone H3</td><td>1347</td><td>0.28</td><td>CD4+</td><td>124</td><td>0.14</td></tr></table>
9419fe23ddc68d08038a8c9124b9c5c473d5c714f2d0f69e9f2d40472c9b05a7.png	complex	<table><tr><td> </td><td colspan="3"><i>2008</i></td><td colspan="3"><i>2009</i></td><td colspan="3"><i>2010</i></td><td colspan="3"><i>2011</i></td></tr><tr><td><i>Province</i></td><td><i>Cattle</i></td><td><i>Goats</i></td><td><i>Sheep</i></td><td><i>Cattle</i></td><td><i>Goats</i></td><td><i>Sheep</i></td><td><i>Cattle</i></td><td><i>Goats</i></td><td><i>Sheep</i></td><td><i>Cattle</i></td><td><i>Goats</i></td><td><i>Sheep</i></td></tr><tr><td>Limpopo</td><td>2.33</td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td>0.02</td><td> </td><td> </td><td> </td></tr><tr><td>Gauteng</td><td>12.60</td><td>91.97</td><td> </td><td> </td><td> </td><td> </td><td>0.38</td><td> </td><td>8.56</td><td> </td><td> </td><td> </td></tr><tr><td>Mpumalanga</td><td>23.89</td><td>1.98</td><td> </td><td> </td><td> </td><td>3.38</td><td> </td><td> </td><td>11.77</td><td> </td><td> </td><td> </td></tr><tr><td>Kwazulu-Natal</td><td> </td><td> </td><td> </td><td>7.22</td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>Northwest</td><td>4.54</td><td> </td><td>1.45</td><td> </td><td> </td><td> </td><td>0.68</td><td> </td><td>24.11</td><td> </td><td> </td><td> </td></tr><tr><td>Free State</td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td>17.22</td><td>29.38</td><td>187.97</td><td> </td><td> </td><td> </td></tr><tr><td>Eastern Cape</td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td>1.16</td><td>0.99</td><td>6.50</td><td>1.58</td><td>3.81</td><td>26.67</td></tr><tr><td>Northern Cape</td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td>5.07</td><td>8.22</td><td>344.18</td><td>0.06</td><td> </td><td>120.99</td></tr><tr><td>Western Cape</td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td>38.69</td><td>15.49</td><td>12.54</td><td>2.16</td><td>108.18</td><td>25.45</td></tr></table>	<table><tr><td></td><td colspan="3">2008</td><td colspan="3">2009</td><td colspan="3">2010</td><td colspan="3">2011</td></tr></table>	<table><tr><td>Province</td><td>Cattle</td><td>Goats</td><td>Sheep</td><td>Cattle</td><td>Goats</td><td>Sheep</td><td>Cattle</td><td>Goats</td><td>Sheep</td><td>Cattle</td><td>Goats</td><td>Sheep</td></tr><tr><td>Limpopo</td><td>2.33</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>0.02</td><td></td><td></td><td></td></tr><tr><td>Gauteng</td><td>12.60</td><td>91.97</td><td></td><td></td><td></td><td></td><td>0.38</td><td></td><td>8.56</td><td></td><td></td><td></td></tr><tr><td>Mpumalanga</td><td>23.89</td><td>1.98</td><td></td><td></td><td></td><td>3.38</td><td></td><td></td><td>11.77</td><td></td><td></td><td></td></tr><tr><td>Kwazulu-Natal</td><td></td><td></td><td></td><td>7.22</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Northwest</td><td>4.54</td><td></td><td>1.45</td><td></td><td></td><td></td><td>0.68</td><td></td><td>24.11</td><td></td><td></td><td></td></tr><tr><td>Free State</td><td></td><td></td><td></td><td></td><td></td><td></td><td>17.22</td><td>29.38</td><td>187.97</td><td></td><td></td><td></td></tr><tr><td>Eastern Cape</td><td></td><td></td><td></td><td></td><td></td><td></td><td>1.16</td><td>0.99</td><td>6.50</td><td>1.58</td><td>3.81</td><td>26.67</td></tr><tr><td>Northern Cape</td><td></td><td></td><td></td><td></td><td></td><td></td><td>5.07</td><td>8.22</td><td>344.18</td><td>0.06</td><td></td><td>120.99</td></tr><tr><td>Western Cape</td><td></td><td></td><td></td><td></td><td></td><td></td><td>38.69</td><td>15.49</td><td>12.54</td><td>2.16</td><td>108.18</td><td>25.45</td></tr></table>
079715311bda10ed1cea9dcc55a6cb3a6ece45122cb4e2ec8504931c923d96a4.png	simple	<table><tr><td><i>Gene</i></td><td><i>Disease</i></td><td><i>Mode of </i><i>inheritance</i></td><td><i>Stroke mechanism</i></td></tr><tr><td><i>GAL</i></td><td><i>Fabry's disease</i></td><td><i>X-linked</i></td><td><i>Large-artery disease and small-vessel disease</i></td></tr><tr><td><i>NOTCH3</i></td><td><i>CADASIL</i></td><td><i>AD</i></td><td><i>Small-vassel disease</i></td></tr><tr><td><i>HBB</i></td><td><i>Sickle-cell disease</i></td><td><i>AR</i></td><td><i>Large-artery disease, small-vessel disease, haemodynamic insufficiency</i></td></tr><tr><td><i>CBS and others</i></td><td><i>Homocystinuria</i></td><td><i>AR</i></td><td><i>Large-artery disease, cardioembolism, small-vessel disease, arterial dissection</i></td></tr><tr><td><i>mtDNA</i></td><td><i>MELAS</i></td><td><i>Maternal</i></td><td><i>Complex (microvascular and neuronal factors)</i></td></tr><tr><td><i>FBN1</i></td><td><i>Marfan syndrome</i></td><td><i>AD</i></td><td><i>Cardioembolism and arterial dissection</i></td></tr><tr><td><i>COL3A1</i></td><td><i>Ehlers-Danlos syndrome type IV</i></td><td><i>AD</i></td><td><i>Arterial dissection</i></td></tr><tr><td><i>ABCC6</i></td><td><i>Pseudoxanthoma elasticum</i></td><td><i>AR</i></td><td><i>Large-artery disease and small-vessel disease</i></td></tr></table>	<table><tr><td>Gene</td><td>Disease</td></tr><tr><td>GAL</td><td>Fabry's disease</td></tr><tr><td>NOTCH3</td><td>CADASIL</td></tr><tr><td>HBB</td><td>Sickle-cell disease</td></tr><tr><td>CBS and others</td><td>Homocystinuria</td></tr><tr><td>mtDNA</td><td>MELAS</td></tr><tr><td>FBN1</td><td>Marfan syndrome</td></tr><tr><td>COL3A1</td><td>Ehlers-Danlos syndrome type IV</td></tr><tr><td>ABCC6</td><td>Pseudoxanthoma elasticum</td></tr></table>	<table><tr><td>Mode of inheritance</td><td>Stroke mechanism</td></tr><tr><td>X-linked</td><td>Large-artery disease and small-vessel disease</td></tr><tr><td>AD</td><td>Small-vassel disease</td></tr><tr><td>AR</td><td>Large-artery disease, small-vessel disease, haemodynamic insufficiency</td></tr><tr><td>AR</td><td>Large-artery disease, cardioembolism, small-vessel disease, arterial dissection</td></tr><tr><td>Maternal</td><td>Complex (microvascular and neuronal factors)</td></tr><tr><td>AD</td><td>Cardioembolism and arterial dissection</td></tr><tr><td>AD</td><td>Arterial dissection</td></tr><tr><td>AR</td><td>Large-artery disease and small-vessel disease</td></tr></table>
2e9f15b9b04f3c98581f4c57a001a8f1fa4519d2e71d1341e1e4b59a69a9a5ff.png	complex	<table><tr><td rowspan="2">Fungi</td><td colspan="8">Minimum fungicidal concentrations of ethanol extract of <i>Cleome gynandra</i> in mg/ml</td><td colspan="2">Controls</td></tr><tr><td>0.5</td><td>0.25</td><td>0.125</td><td>0.0625</td><td>0.0313</td><td>0.0156</td><td>0.00781</td><td>0.00391</td><td>−ve ctrl</td><td>+ ctrl</td></tr><tr><td>Mc</td><td>Nfgo</td><td>Fgo</td><td>Fgo</td><td>Fgo</td><td>Fgo</td><td>Fgo</td><td>Fgo</td><td>Fgo</td><td>Fgo</td><td>Nfgo</td></tr><tr><td>Tm</td><td>Nfgo</td><td>Fgo</td><td>Fgo</td><td>Fgo</td><td>Fgo</td><td>Fgo</td><td>Fgo</td><td>Fgo</td><td>Fgo</td><td>Nfgo</td></tr><tr><td>Tr</td><td>Nfgo</td><td>Nfgo</td><td>Nfgo</td><td>Fgo</td><td>Fgo</td><td>Fgo</td><td>Fgo</td><td>Fgo</td><td>Fgo</td><td>Nfgo</td></tr></table>	<table><tr><td rowspan="2">Fungi</td><td colspan="5">Minimum fungicidal concentrations of ethanol extract of Cleome gynandra in mg/ml</td></tr><tr><td>0.5</td><td>0.25</td><td>0.125</td><td>0.0625</td><td>0.0313</td></tr><tr><td>Mc</td><td>Nfgo</td><td>Fgo</td><td>Fgo</td><td>Fgo</td><td>Fgo</td></tr><tr><td>Tm</td><td>Nfgo</td><td>Fgo</td><td>Fgo</td><td>Fgo</td><td>Fgo</td></tr><tr><td>Tr</td><td>Nfgo</td><td>Nfgo</td><td>Nfgo</td><td>Fgo</td><td>Fgo</td></tr></table>	<table><tr><td colspan="3">Minimum fungicidal concentrations of ethanol extract of Cleome gynandra in mg/ml</td><td colspan="2">Controls</td></tr><tr><td>0.0156</td><td>0.00781</td><td>0.00391</td><td>−ve ctrl</td><td>+ ctrl</td></tr><tr><td>Fgo</td><td>Fgo</td><td>Fgo</td><td>Fgo</td><td>Nfgo</td></tr><tr><td>Fgo</td><td>Fgo</td><td>Fgo</td><td>Fgo</td><td>Nfgo</td></tr><tr><td>Fgo</td><td>Fgo</td><td>Fgo</td><td>Fgo</td><td>Nfgo</td></tr></table>
88091677bd29de7e8fd88b58e0eb1ed257493997ae57f50df166c358d225364d.png	simple	<table><tr><td>Testing completed</td><td><i>N</i> (%)</td></tr><tr><td>Actionable</td><td>92 (65%)</td></tr><tr><td>Not actionable or informative</td><td>35 (25%)</td></tr><tr><td>Informative</td><td>11 (8%)</td></tr><tr><td>No reportable results</td><td>2 (1%)</td></tr><tr><td>Test failed</td><td>1 (< 1%)</td></tr></table>	<table><tr><td>Testing completed</td></tr><tr><td>Actionable</td></tr><tr><td>Not actionable or informative</td></tr><tr><td>Informative</td></tr><tr><td>No reportable results</td></tr><tr><td>Test failed</td></tr></table>	<table><tr><td>N (%)</td></tr><tr><td>92 (65%)</td></tr><tr><td>35 (25%)</td></tr><tr><td>11 (8%)</td></tr><tr><td>2 (1%)</td></tr><tr><td>1 (< 1%)</td></tr></table>
764844cfbb1981fa3274cac0dff6391c03e174de7f1a2bd1a3aaf6202a7d35cf.png	complex	<table><tr><td colspan="2">Escala de risco de sangramento RIETE modificada</td></tr><tr><td>Variável</td><td>Pontos</td></tr><tr><td>Hemorragia maior recente (< 1 mês)</td><td>2</td></tr><tr><td>Creatinina > 1,2 mg/dL</td><td>1,5</td></tr><tr><td>Anemia</td><td>1,5</td></tr><tr><td>Câncer</td><td>1</td></tr><tr><td>Idade > 75 anos</td><td>5</td></tr><tr><td colspan="2">Risco baixo: 0; Risco intermediário: 1-4; Risco alto: > 4</td></tr></table>	<table><tr><td>Escala de risco de sangramento RIETE modificada</td></tr><tr><td>Variável</td></tr><tr><td>Hemorragia maior recente (< 1 mês)</td></tr><tr><td>Creatinina > 1,2 mg/dL</td></tr><tr><td>Anemia</td></tr><tr><td>Câncer</td></tr><tr><td>Idade > 75 anos</td></tr><tr><td>Risco baixo: 0; Risco intermediário: 1-4; Risco alto: > 4</td></tr></table>	<table><tr><td>Escala de risco de sangramento RIETE modificada</td></tr><tr><td>Pontos</td></tr><tr><td>2</td></tr><tr><td>1,5</td></tr><tr><td>1,5</td></tr><tr><td>1</td></tr><tr><td>5</td></tr><tr><td>Risco baixo: 0; Risco intermediário: 1-4; Risco alto: > 4</td></tr></table>
3fc65e06ca6c36f2c9f1dd26f3ab6fd9382af047a2d83d2a59f06fcf35cac3fa.png	complex	<table><tr><td></td><td colspan="3">Percentage reporting ‘never’ undertaking measure for reducing risk of violence</td><td></td></tr><tr><td></td><td>M</td><td>F</td><td>N</td><td>Significance χ<sup>2</sup></td></tr><tr><td>Check patient notes in advance</td><td>52</td><td>37</td><td>620</td><td>p<.001</td></tr><tr><td>Leave door ajar when seeing certain patients</td><td>80</td><td>67</td><td>604</td><td>p<.001</td></tr><tr><td>Accompanied when seeing certain patients</td><td>70</td><td>64</td><td>610</td><td>p<.05</td></tr><tr><td>Accompanied on visits to certain patients</td><td>77</td><td>65</td><td>610</td><td>p<.005</td></tr><tr><td>Leaving visit schedule with someone</td><td>48</td><td>25</td><td>618</td><td>p<.001</td></tr><tr><td>Carry personal alarm</td><td>95</td><td>77</td><td>583</td><td>p<.001</td></tr><tr><td>Attended self‐defence course</td><td>94</td><td>85</td><td>590</td><td>p<.005</td></tr></table>	<table><tr><td></td><td colspan="3">Percentage reporting ‘never’ undertaking measure for reducing risk of violence</td><td></td></tr><tr><td></td><td>M</td><td>F</td><td>N</td><td>Significance χ2</td></tr><tr><td>Check patient notes in advance</td><td>52</td><td>37</td><td>620</td><td>p<.001</td></tr><tr><td>Leave door ajar when seeing certain patients</td><td>80</td><td>67</td><td>604</td><td>p<.001</td></tr><tr><td>Accompanied when seeing certain patients</td><td>70</td><td>64</td><td>610</td><td>p<.05</td></tr><tr><td>Acc</td><td>7</td><td>65</td><td>610</td><td>p<</td></tr></table>	<table><tr><td></td><td colspan="3">Percentage reporting ‘never’ undertaking measure for reducing risk of violence</td><td></td></tr><tr><td></td><td>M</td><td>F</td><td>N</td><td>Significance χ2</td></tr><tr><td>ompanied on visits to certain patients</td><td>7</td><td></td><td></td><td>.005</td></tr><tr><td>Leaving visit schedule with someone</td><td>48</td><td>25</td><td>618</td><td>p<.001</td></tr><tr><td>Carry personal alarm</td><td>95</td><td>77</td><td>583</td><td>p<.001</td></tr><tr><td>Attended self‐defence course</td><td>94</td><td>85</td><td>590</td><td>p<.005</td></tr></table>
b8303fb9f5d52cac87ac16d9512c0a608f7076e87f0c92d333b19f7f97743dce.png	complex	<table><tr><td>Pt</td><td>Chromosome</td><td>Probes/libraries</td><td>Band localization</td><td>Genomic Localization (bp) (hg19)</td></tr><tr><td>1</td><td>8</td><td>AML1/ETO<sup>a</sup>WCP 1<sup>b</sup></td><td>designed for t(8;21)Whole chromosome paint library</td><td>–</td></tr><tr><td rowspan="2">2</td><td>2</td><td>WCP 2<sup>b</sup>CTD-2314L14<sup>c</sup>CTD-2599D22<sup>c</sup>ALK<sup>d</sup>CTD-3028D11 <sup>c</sup>CTD-2232H14<sup>c</sup>CTD-2566H13<sup>c</sup>CTD-2532N8<sup>c</sup>CTD-2371H10<sup>c</sup>CTD-2382F21<sup>c</sup>CTD-2052G24<sup>c</sup>CTD-3058K15<sup>c</sup></td><td>Whole chromosome paint library2p23.32p23.22p23.2–23.12p23.12p22.22p22.2–22.12p21.32p21.12p16.32p152p15–14</td><td>27,436,476–27,577,216 bp29,678,603–29,819,833 bp-31,532,615–31,667,611 bp36,717,490–36,828,693 bp38,563,970–38,725,504 bp42,157,290–42,301,116 bp46,582,036–46,715,607 bp48,326,711–48,434,143 bp61,463,234–61,600,608 bp64,034,477–64,232,972 bp</td></tr><tr><td>8</td><td>WCP 8<sup>b</sup>AML1/ETO<sup>a</sup>CTD-2341G19<sup>c</sup>CTD-2246G22<sup>c</sup>CTD-3245G9<sup>c</sup>CTD-2330N9<sup>c</sup></td><td>Whole chromosome paint library designed for t(8;21)8q21.138q21.38q21.38q21.3</td><td>-83,886,651–83,982,215 bp87,885,140–87,980,460 bp91,740,722–91,959,017 bp92,778,106–92,922,619 bp</td></tr></table>	<table><tr><td>Pt</td><td>Chromosome</td><td>Probes/libraries</td><td>Band localization</td><td>Genomic Localization (bp) (hg19)</td></tr><tr><td>1</td><td>8</td><td>AML1/ETOaWCP 1b</td><td>designed for t(8;21)Whole chromosome paint library</td><td>–</td></tr></table>	<table><tr><td>Pt</td><td>Chromosome</td><td>Probes/libraries</td><td>Band localization</td><td>Genomic Localization (bp) (hg19)</td></tr><tr><td rowspan="2">2</td><td>2</td><td>WCP 2bCTD-2314L14cCTD-2599D22cALKdCTD-3028D11 cCTD-2232H14cCTD-2566H13cCTD-2532N8cCTD-2371H10cCTD-2382F21cCTD-2052G24cCTD-3058K15c</td><td>Whole chromosome paint library2p23.32p23.22p23.2–23.12p23.12p22.22p22.2–22.12p21.32p21.12p16.32p152p15–14</td><td>27,436,476–27,577,216 bp29,678,603–29,819,833 bp-31,532,615–31,667,611 bp36,717,490–36,828,693 bp38,563,970–38,725,504 bp42,157,290–42,301,116 bp46,582,036–46,715,607 bp48,326,711–48,434,143 bp61,463,234–61,600,608 bp64,034,477–64,232,972 bp</td></tr><tr><td>8</td><td>WCP 8bAML1/ETOaCTD-2341G19cCTD-2246G22cCTD-3245G9cCTD-2330N9c</td><td>Whole chromosome paint library designed for t(8;21)8q21.138q21.38q21.38q21.3</td><td>-83,886,651–83,982,215 bp87,885,140–87,980,460 bp91,740,722–91,959,017 bp92,778,106–92,922,619 bp</td></tr></table>
06e59ca022e490995b3744620905645031b87bcf76f076b54f513d84a7729a00.png	simple	<table><tr><td>FIRST GENE (REFSEQ ACCESSION NUMBER)</td><td>FIRST GENE (AHR BINDING SITES)</td><td>FIRST GENE (BINDING SITES OF OTHER TFS)</td><td>SECOND GENE (REFSEQ ACCESSION NUMBER)</td><td>SECOND GENE (AHR BINDING SITES)</td><td>SECOND GENE (BINDING SITES OF OTHER TFS)</td></tr><tr><td>NM_003928</td><td>-</td><td>-</td><td>NM_015582</td><td>n.d.</td><td>n.d.</td></tr><tr><td>NM_005334</td><td>-</td><td>NFKB</td><td>NM_003492</td><td>1</td><td>ATF3, SP2</td></tr><tr><td>NM_001643</td><td>-</td><td>PPARG2</td><td>NM_032174</td><td>1</td><td>-</td></tr><tr><td>NM_021642</td><td>1</td><td>-</td><td>NM_002155</td><td>-</td><td>NFKB</td></tr><tr><td>NM_005807</td><td>-</td><td>-</td><td>NM_003292</td><td>-</td><td>SP2</td></tr><tr><td>NM_006623</td><td>-</td><td>-</td><td>NM_005518</td><td>-</td><td>PPARG2</td></tr><tr><td>NM_002061</td><td>1</td><td>SP2</td><td>NM_000350</td><td>-</td><td>-</td></tr><tr><td>NM_144631</td><td>2</td><td>RFXANK</td><td>NM_002707</td><td>1</td><td>PPARG2</td></tr><tr><td>NM_005911</td><td>-</td><td>SP2, PPARG2</td><td>NM_000821</td><td>1</td><td>PPARG2</td></tr><tr><td>NM_016467</td><td>-</td><td>PPARG2</td><td>NM_000534</td><td>-</td><td>NFKB</td></tr><tr><td>NM_022173</td><td>1</td><td>-</td><td>NM_016297</td><td>1</td><td>RFXANK, SP2</td></tr><tr><td>NM_006590</td><td>1</td><td>-</td><td>NM_000542</td><td>-</td><td>NRF1, PPARG2</td></tr><tr><td>NM_005141</td><td>-</td><td>-</td><td>NM_000508</td><td>-</td><td>-</td></tr><tr><td>NM_000508</td><td>-</td><td>-</td><td>NM_000509</td><td>-</td><td>-</td></tr><tr><td>NM_007104</td><td>-</td><td>-</td><td>NM_003214</td><td>1</td><td>SP2</td></tr><tr><td>NM_138446</td><td>1</td><td>-</td><td>NM_006547</td><td>-</td><td>BHLHB2</td></tr><tr><td>NM_003235</td><td>-</td><td>-</td><td>NM_006748</td><td>-</td><td>-</td></tr><tr><td>NM_001261</td><td>-</td><td>NFKB</td><td>NM_004957</td><td>-</td><td>PBX1, SP2</td></tr><tr><td>NM_005564</td><td>-</td><td>NFKB</td><td>NM_024112</td><td>-</td><td>SP2</td></tr><tr><td>NM_005489</td><td>-</td><td>SP2</td><td>NM_001261</td><td>-</td><td>-</td></tr><tr><td>NM_004376</td><td>-</td><td>NFKB</td><td>NM_015960</td><td>-</td><td>PPARG2</td></tr><tr><td>NM_005271</td><td>5</td><td>BHLHB2</td><td>NM_019054</td><td>3</td><td>-</td></tr><tr><td>NM_001572</td><td>-</td><td>SP2, NFKB</td><td>NM_021924</td><td>1</td><td>SP2</td></tr><tr><td>NM_052854</td><td>-</td><td>SP2</td><td>NM_003646</td><td>-</td><td>SP2, PPARG2</td></tr><tr><td>NM_006169</td><td>-</td><td>RFXANK</td><td>NM_019021</td><td>1</td><td>PPARG2</td></tr><tr><td>NM_021640</td><td>-</td><td>-</td><td>NM_015665</td><td>-</td><td>NFKB</td></tr><tr><td>NM_003348</td><td>1</td><td>-</td><td>NM_014050</td><td>-</td><td>-</td></tr><tr><td>NM_002937</td><td>-</td><td>PPARG2</td><td>NM_001145</td><td>-</td><td>-</td></tr><tr><td>NM_006599</td><td>-</td><td>NFKB, BHLHB2</td><td>NM_000903</td><td>1</td><td>NRF1</td></tr><tr><td>NM_003562</td><td>1</td><td>RFXANK</td><td>NM_015528</td><td>1</td><td>NFKB, RFXANK</td></tr><tr><td>NM_002544</td><td>1</td><td>-</td><td>NM_006495</td><td>-</td><td>-</td></tr><tr><td>NM_018952</td><td>-</td><td>NFKB, RFXANK</td><td>NM_004502</td><td>2</td><td>RFXANK, BHLHB2</td></tr><tr><td>NM_007292</td><td>2</td><td>NFKB, BHLHB2</td><td>NM_001258</td><td>-</td><td>PPARG2</td></tr><tr><td>NM_005359</td><td>-</td><td>-</td><td>NM_016626</td><td>1</td><td>SP2</td></tr><tr><td>NM_032377</td><td>-</td><td>RFXANK</td><td>NM_001611</td><td>2</td><td>BHLHB2, PPARG2</td></tr><tr><td>NM_018270</td><td>2</td><td>-</td><td>NM_007346</td><td>-</td><td>RFXANK, BHLHB2</td></tr><tr><td>NM_002626</td><td>2</td><td>SP2</td><td>NM_004928</td><td>1</td><td>SP2</td></tr></table>	<table><tr><td>FIRST GENE (REFSEQ ACCESSION NUMBER)</td><td>FIRST GENE (AHR BINDING SITES)</td><td>FIRST GENE (BINDING SITES OF OTHER TFS)</td><td>SECOND GENE (REFSEQ ACCESSION NUMBER)</td><td>SECOND GENE (AHR BINDING SITES)</td><td>SECOND GENE (BINDING SITES OF OTHER TFS)</td></tr><tr><td>NM_003928</td><td>-</td><td>-</td><td>NM_015582</td><td>n.d.</td><td>n.d.</td></tr><tr><td>NM_005334</td><td>-</td><td>NFKB</td><td>NM_003492</td><td>1</td><td>ATF3, SP2</td></tr><tr><td>NM_001643</td><td>-</td><td>PPARG2</td><td>NM_032174</td><td>1</td><td>-</td></tr><tr><td>NM_021642</td><td>1</td><td>-</td><td>NM_002155</td><td>-</td><td>NFKB</td></tr><tr><td>NM_005807</td><td>-</td><td>-</td><td>NM_003292</td><td>-</td><td>SP2</td></tr><tr><td>NM_006623</td><td>-</td><td>-</td><td>NM_005518</td><td>-</td><td>PPARG2</td></tr><tr><td>NM_002061</td><td>1</td><td>SP2</td><td>NM_000350</td><td>-</td><td>-</td></tr><tr><td>NM_144631</td><td>2</td><td>RFXANK</td><td>NM_002707</td><td>1</td><td>PPARG2</td></tr><tr><td>NM_005911</td><td>-</td><td>SP2, PPARG2</td><td>NM_000821</td><td>1</td><td>PPARG2</td></tr><tr><td>NM_016467</td><td>-</td><td>PPARG2</td><td>NM_000534</td><td>-</td><td>NFKB</td></tr><tr><td>NM_022173</td><td>1</td><td>-</td><td>NM_016297</td><td>1</td><td>RFXANK, SP2</td></tr><tr><td>NM_006590</td><td>1</td><td>-</td><td>NM_000542</td><td>-</td><td>NRF1, PPARG2</td></tr><tr><td>NM_005141</td><td>-</td><td>-</td><td>NM_000508</td><td>-</td><td>-</td></tr><tr><td>NM_000508</td><td>-</td><td>-</td><td>NM_000509</td><td>-</td><td>-</td></tr><tr><td>NM_007104</td><td>-</td><td>-</td><td>NM_003214</td><td>1</td><td>SP2</td></tr></table>	<table><tr><td>FIRST GENE (REFSEQ ACCESSION NUMBER)</td><td>FIRST GENE (AHR BINDING SITES)</td><td>FIRST GENE (BINDING SITES OF OTHER TFS)</td><td>SECOND GENE (REFSEQ ACCESSION NUMBER)</td><td>SECOND GENE (AHR BINDING SITES)</td><td>SECOND GENE (BINDING SITES OF OTHER TFS)</td></tr><tr><td>NM_138446</td><td>1</td><td>-</td><td>NM_006547</td><td>-</td><td>BHLHB2</td></tr><tr><td>NM_003235</td><td>-</td><td>-</td><td>NM_006748</td><td>-</td><td>-</td></tr><tr><td>NM_001261</td><td>-</td><td>NFKB</td><td>NM_004957</td><td>-</td><td>PBX1, SP2</td></tr><tr><td>NM_005564</td><td>-</td><td>NFKB</td><td>NM_024112</td><td>-</td><td>SP2</td></tr><tr><td>NM_005489</td><td>-</td><td>SP2</td><td>NM_001261</td><td>-</td><td>-</td></tr><tr><td>NM_004376</td><td>-</td><td>NFKB</td><td>NM_015960</td><td>-</td><td>PPARG2</td></tr><tr><td>NM_005271</td><td>5</td><td>BHLHB2</td><td>NM_019054</td><td>3</td><td>-</td></tr><tr><td>NM_001572</td><td>-</td><td>SP2, NFKB</td><td>NM_021924</td><td>1</td><td>SP2</td></tr><tr><td>NM_052854</td><td>-</td><td>SP2</td><td>NM_003646</td><td>-</td><td>SP2, PPARG2</td></tr><tr><td>NM_006169</td><td>-</td><td>RFXANK</td><td>NM_019021</td><td>1</td><td>PPARG2</td></tr><tr><td>NM_021640</td><td>-</td><td>-</td><td>NM_015665</td><td>-</td><td>NFKB</td></tr><tr><td>NM_003348</td><td>1</td><td>-</td><td>NM_014050</td><td>-</td><td>-</td></tr><tr><td>NM_002937</td><td>-</td><td>PPARG2</td><td>NM_001145</td><td>-</td><td>-</td></tr><tr><td>NM_006599</td><td>-</td><td>NFKB, BHLHB2</td><td>NM_000903</td><td>1</td><td>NRF1</td></tr><tr><td>NM_003562</td><td>1</td><td>RFXANK</td><td>NM_015528</td><td>1</td><td>NFKB, RFXANK</td></tr><tr><td>NM_002544</td><td>1</td><td>-</td><td>NM_006495</td><td>-</td><td>-</td></tr><tr><td>NM_018952</td><td>-</td><td>NFKB, RFXANK</td><td>NM_004502</td><td>2</td><td>RFXANK, BHLHB2</td></tr><tr><td>NM_007292</td><td>2</td><td>NFKB, BHLHB2</td><td>NM_001258</td><td>-</td><td>PPARG2</td></tr><tr><td>NM_005359</td><td>-</td><td>-</td><td>NM_016626</td><td>1</td><td>SP2</td></tr><tr><td>NM_032377</td><td>-</td><td>RFXANK</td><td>NM_001611</td><td>2</td><td>BHLHB2, PPARG2</td></tr><tr><td>NM_018270</td><td>2</td><td>-</td><td>NM_007346</td><td>-</td><td>RFXANK, BHLHB2</td></tr><tr><td>NM_002626</td><td>2</td><td>SP2</td><td>NM_004928</td><td>1</td><td>SP2</td></tr></table>
2009d6ddd858d4051f6b3588c8295ec3e123c01400fc1c40703930ffe5d77978.png	simple	<table><tr><td>Plant Part</td><td>Subject of Study</td><td>Effect</td><td>Reference</td></tr><tr><td>ethyl acetate extract of the leaves</td><td>lung A549 cancer cells</td><td>mitochondrial-mediated apoptosis, cell cycle arrest at G<sub>1</sub> phase</td><td>[83]</td></tr><tr><td>ethyl acetate extract of the leaves</td><td>colon HT-29 and HCT-116 cancer cells</td><td>mitochondrial-mediated apoptosis, cell cycle arrest at G<sub>1</sub> phase, suppression of migration and invasion</td><td>[84]</td></tr><tr><td>water extract of the leaves</td><td>rat’s prostate</td><td>reduction of prostate size</td><td>[86]</td></tr><tr><td>ethanolic extract of the leaves</td><td>breast tissues of mice</td><td>prevention of DMBA-induced DNA damage</td><td>[87]</td></tr><tr><td>ethanolic extract of the leaves</td><td>DMBA/croton oil induced mice skin papillomagenesis</td><td>suppression of tumor initiation and promotion</td><td>[88]</td></tr><tr><td>ethanolic extract of the leaves</td><td>DMH induced colon cancer</td><td>reduction of ACF formation</td><td>[89]</td></tr><tr><td>ethanolic extract of the leaves</td><td>K562 chronic myeloid leukemia cells</td><td>induction of apoptosis</td><td>[85]</td></tr><tr><td>leaves boiled in water</td><td>metastatic breast cancer</td><td>stabilization of disease</td><td>[90]</td></tr><tr><td>ethyl acetate of the leaves</td><td>azoxymethane induced colon cancer</td><td>reduction of ACF formation</td><td>[91]</td></tr><tr><td>ethyl acetate of the leaves</td><td>colon HT-29 cancer cells</td><td>bioassay-guided isolation of annomuricin E and its apoptosis inducing effect</td><td>[91]</td></tr></table>	<table><tr><td>Plant Part</td><td>Subject of Study</td></tr><tr><td>ethyl acetate extract of the leaves</td><td>lung A549 cancer cells</td></tr><tr><td>ethyl acetate extract of the leaves</td><td>colon HT-29 and HCT-116 cancer cells</td></tr><tr><td>water extract of the leaves</td><td>rat’s prostate</td></tr><tr><td>ethanolic extract of the leaves</td><td>breast tissues of mice</td></tr><tr><td>ethanolic extract of the leaves</td><td>DMBA/croton oil induced mice skin papillomagenesis</td></tr><tr><td>ethanolic extract of the leaves</td><td>DMH induced colon cancer</td></tr><tr><td>ethanolic extract of the leaves</td><td>K562 chronic myeloid leukemia cells</td></tr><tr><td>leaves boiled in water</td><td>metastatic breast cancer</td></tr><tr><td>ethyl acetate of the leaves</td><td>azoxymethane induced colon cancer</td></tr><tr><td>ethyl acetate of the leaves</td><td>colon HT-29 cancer cells</td></tr></table>	<table><tr><td>Effect</td><td>Reference</td></tr><tr><td>mitochondrial-mediated apoptosis, cell cycle arrest at G1 phase</td><td>[83]</td></tr><tr><td>mitochondrial-mediated apoptosis, cell cycle arrest at G1 phase, suppression of migration and invasion</td><td>[84]</td></tr><tr><td>reduction of prostate size</td><td>[86]</td></tr><tr><td>prevention of DMBA-induced DNA damage</td><td>[87]</td></tr><tr><td>suppression of tumor initiation and promotion</td><td>[88]</td></tr><tr><td>reduction of ACF formation</td><td>[89]</td></tr><tr><td>induction of apoptosis</td><td>[85]</td></tr><tr><td>stabilization of disease</td><td>[90]</td></tr><tr><td>reduction of ACF formation</td><td>[91]</td></tr><tr><td>bioassay-guided isolation of annomuricin E and its apoptosis inducing effect</td><td>[91]</td></tr></table>
86ce7f81a64b2bc71f48f0e8750b87f2ea25657acc9b0b0ac1670ad7aae27c86.png	simple	<table><tr><td>Number</td><td>Gender</td><td>Age</td><td>Treatment</td><td>Diagnosis of infection</td><td>Bacterial etiology</td><td>Days of infection detected after TACE and/or RFA</td><td>PCT on day of fever</td><td>Peak PCT within 7 days</td><td>Outcome of infection</td></tr><tr><td>1</td><td>M</td><td>57</td><td>TACE</td><td>Cholecystitis</td><td>Bile, <i>E. hirae</i></td><td>4</td><td>2.58</td><td>2.58</td><td>Cured</td></tr><tr><td>2</td><td>M</td><td>83</td><td>TACE</td><td>Pneumonia</td><td>—</td><td>5</td><td>0.72</td><td>0.72</td><td>Cured</td></tr><tr><td>3</td><td>M</td><td>55</td><td>TACE</td><td>UTI</td><td>—</td><td>4</td><td>0.23</td><td>2.40</td><td>Cured</td></tr><tr><td>4</td><td>M</td><td>75</td><td>TACE</td><td>Bacteremia, primary</td><td>Blood, <i>E. coli</i></td><td>2</td><td>1.55</td><td>1.70</td><td>Cured</td></tr><tr><td>5</td><td>M</td><td>79</td><td>TACE</td><td>UTI</td><td>—</td><td>3</td><td>1.19</td><td>1.19</td><td>Cured</td></tr><tr><td>6</td><td>M</td><td>73</td><td>TACE</td><td>Pneumonia</td><td>Sputum, <i>E. coli</i></td><td>7</td><td>0.21</td><td>0.24</td><td>Cured</td></tr><tr><td>7</td><td>F</td><td>77</td><td>Sequential TACE/RFA</td><td>Liver abscess</td><td>Blood, <i>E. casseliflavus</i></td><td>7</td><td>0.16</td><td>0.59</td><td>Transferred to another hospital</td></tr><tr><td>8</td><td>M</td><td>71</td><td>TACE</td><td>Bacteremia, cholangitis</td><td>Blood, <i>E. gallinarum</i></td><td>1</td><td>0.15</td><td>0.55</td><td>Cured</td></tr><tr><td>9</td><td>F</td><td>65</td><td>RFA</td><td>Bacteremia, RFA site cutaneous abscess</td><td>Blood, <i>S. aureus</i></td><td>1</td><td>0.08</td><td>0.17</td><td>Cured</td></tr></table>	<table><tr><td>Number</td><td>Gender</td><td>Age</td><td>Treatment</td><td>Diagnosis of infection</td><td>Bacterial etiology</td><td>Days of infection detected after TACE and/or RFA</td><td>PCT on day of fever</td><td>Peak PCT within 7 days</td><td>Outcome of infection</td></tr><tr><td>1</td><td>M</td><td>57</td><td>TACE</td><td>Cholecystitis</td><td>Bile, E. hirae</td><td>4</td><td>2.58</td><td>2.58</td><td>Cured</td></tr><tr><td>2</td><td>M</td><td>83</td><td>TACE</td><td>Pneumonia</td><td>—</td><td>5</td><td>0.72</td><td>0.72</td><td>Cured</td></tr><tr><td>3</td><td>M</td><td>55</td><td>TACE</td><td>UTI</td><td>—</td><td>4</td><td>0.23</td><td>2.40</td><td>Cured</td></tr><tr><td>4</td><td>M</td><td>75</td><td>TACE</td><td>Bacteremia, primary</td><td>Blood, E. coli</td><td>2</td><td>1.55</td><td>1.70</td><td>Cured</td></tr><tr><td>5</td><td>M</td><td>79</td><td>TACE</td><td>UTI</td><td>—</td><td>3</td><td>1.19</td><td>1.19</td><td>Cured</td></tr></table>	<table><tr><td>Number</td><td>Gender</td><td>Age</td><td>Treatment</td><td>Diagnosis of infection</td><td>Bacterial etiology</td><td>Days of infection detected after TACE and/or RFA</td><td>PCT on day of fever</td><td>Peak PCT within 7 days</td><td>Outcome of infection</td></tr><tr><td>6</td><td>M</td><td>73</td><td>TACE</td><td>Pneumonia</td><td>Sputum, E. coli</td><td>7</td><td>0.21</td><td>0.24</td><td>Cured</td></tr><tr><td>7</td><td>F</td><td>77</td><td>Sequential TACE/RFA</td><td>Liver abscess</td><td>Blood, E. casseliflavus</td><td>7</td><td>0.16</td><td>0.59</td><td>Transferred to another hospital</td></tr><tr><td>8</td><td>M</td><td>71</td><td>TACE</td><td>Bacteremia, cholangitis</td><td>Blood, E. gallinarum</td><td>1</td><td>0.15</td><td>0.55</td><td>Cured</td></tr><tr><td>9</td><td>F</td><td>65</td><td>RFA</td><td>Bacteremia, RFA site cutaneous abscess</td><td>Blood, S. aureus</td><td>1</td><td>0.08</td><td>0.17</td><td>Cured</td></tr></table>
0480358c0e4b42e5ba9948a191c8ed18d9525fedcd35ee8e66fccaf1b5516435.png	simple	<table><tr><td>Type of Gholonj</td><td>Traditional term</td><td>Type of obstruction</td><td>Pathology</td></tr><tr><td>Inflammatory Gholonj</td><td>Gholonj-e-varami</td><td>Non mechanical</td><td>Inflammation in the intestinal wall or surrounding organs</td></tr><tr><td>Secretory Gholonj</td><td>Gholonj-e-balghami</td><td>Non mechanical</td><td>Accumulation of mucoid Phlegm in lumen of intestine</td></tr><tr><td>Flatulency Gholonj</td><td>Gholonj-e-reehi</td><td>Non mechanical</td><td>High gas accumulation in the lumen of intestine</td></tr><tr><td>Fecal Gholonj</td><td>Gholonj-e-sofli</td><td>Mechanical</td><td>Accumulation of fecal masses</td></tr><tr><td>Parasitic Gholonj</td><td>Gholonj-e-doodi</td><td>Mechanical</td><td>Aggregation of worms in the lumen of intestine</td></tr><tr><td>Torsion Gholonj</td><td>Gholonj-e-eltevaee</td><td>Mechanical</td><td>Intestinal torsion or bowel herniation</td></tr></table>	<table><tr><td>Type of Gholonj</td><td>Traditional term</td><td>Type of obstruction</td><td>Pathology</td></tr><tr><td>Inflammatory Gholonj</td><td>Gholonj-e-varami</td><td>Non mechanical</td><td>Inflammation in the intestinal wall or surrounding organs</td></tr><tr><td>Secretory Gholonj</td><td>Gholonj-e-balghami</td><td>Non mechanical</td><td>Accumulation of mucoid Phlegm in lumen of intestine</td></tr><tr><td>Flatulency Gholonj</td><td>Gholonj-e-reehi</td><td>Non mechanical</td><td>High gas accumulation in the lumen of intestine</td></tr><tr><td>Fecal Gholonj</td><td>Gholonj-e-sofli</td><td>Mechanical</td><td>Accumulation of fecal masses</td></tr><tr><td>Parasitic Gholonj</td><td>Gholonj-e-doodi</td><td>Mechanical</td><td>Aggregation of worms in the lumen of intestine</td></tr></table>	<table><tr><td>Type of Gholonj</td><td>Traditional term</td><td>Type of obstruction</td><td>Pathology</td></tr><tr><td>Torsion Gholonj</td><td>Gholonj-e-eltevaee</td><td>Mechanical</td><td>Intestinal torsion or bowel herniation</td></tr></table>
cd381abe4a4c5d0e9cee93798a4b514d4b0d330038c02c5bbe2a62f07e57d996.png	complex	<table><tr><td></td><td colspan="3">TGF-β1 Release</td><td></td><td colspan="3">BDNF Release</td><td></td></tr><tr><td>LPS</td><td><i>E. coli</i></td><td></td><td><i>V. vulnificus</i></td><td></td><td><i>E. coli</i></td><td></td><td><i>V. vulnificus</i></td><td></td></tr><tr><td>(ng/mL)</td><td>(pg/mL)</td><td><i>n</i><sup>1</sup></td><td>(pg/mL)</td><td><i>n</i><sup>1</sup></td><td>(pg/mL)</td><td><i>n</i><sup>1</sup></td><td>(pg/mL)</td><td><i>n</i><sup>1</sup></td></tr><tr><td>0</td><td>319.7 ± 50.1</td><td>3</td><td>319.7 ± 50.1</td><td>3</td><td>0</td><td>2</td><td>0</td><td>2</td></tr><tr><td>0.1</td><td>424.3 ± 40.3</td><td>3</td><td>386 ± 16.0</td><td>2</td><td>5.1 ± 4.4</td><td>2</td><td>1.4 ± 0.8</td><td>2</td></tr><tr><td>1</td><td>363.3 ± 36</td><td>3</td><td>419 ± 66.9</td><td>3</td><td>18.4 ± 14.9</td><td>2</td><td>10.2 ± 6.2</td><td>2</td></tr><tr><td>10</td><td>318.7 ± 73.2</td><td>3</td><td>358 ± 50.1</td><td>3</td><td>6.9 ± 3.9</td><td>2</td><td>6.5 ± 5.5</td><td>2</td></tr><tr><td>100</td><td>333.3 ± 58.6</td><td>3</td><td>310 ± 51.6</td><td>3</td><td>6.6 ± 3.0</td><td>2</td><td>9.1 ± 4.7</td><td>2</td></tr><tr><td>1000</td><td>ND</td><td></td><td>352 ± 55.5</td><td>3</td><td>ND</td><td></td><td>7.5 ± 7.5</td><td>2</td></tr><tr><td>10,000</td><td>ND</td><td></td><td>613 ± 58.7</td><td>3</td><td>ND</td><td></td><td>0 ± 0</td><td>2</td></tr><tr><td>100,000</td><td>ND</td><td></td><td>973.5 ± 264.5 *</td><td>2</td><td>ND</td><td></td><td>2.05 ± 2.05</td><td>2</td></tr></table>	<table><tr><td></td><td colspan="3">TGF-β1 Release</td><td></td><td colspan="3">BDNF Release</td><td></td></tr><tr><td>LPS</td><td>E. coli</td><td></td><td>V. vulnificus</td><td></td><td>E. coli</td><td></td><td>V. vulnificus</td><td></td></tr><tr><td>(ng/mL)</td><td>(pg/mL)</td><td>n1</td><td>(pg/mL)</td><td>n1</td><td>(pg/mL)</td><td>n1</td><td>(pg/mL)</td><td>n1</td></tr></table>	<table><tr><td>0</td><td>319.7 ± 50.1</td><td>3</td><td>319.7 ± 50.1</td><td>3</td><td>0</td><td>2</td><td>0</td><td>2</td></tr><tr><td>0.1</td><td>424.3 ± 40.3</td><td>3</td><td>386 ± 16.0</td><td>2</td><td>5.1 ± 4.4</td><td>2</td><td>1.4 ± 0.8</td><td>2</td></tr><tr><td>1</td><td>363.3 ± 36</td><td>3</td><td>419 ± 66.9</td><td>3</td><td>18.4 ± 14.9</td><td>2</td><td>10.2 ± 6.2</td><td>2</td></tr><tr><td>10</td><td>318.7 ± 73.2</td><td>3</td><td>358 ± 50.1</td><td>3</td><td>6.9 ± 3.9</td><td>2</td><td>6.5 ± 5.5</td><td>2</td></tr><tr><td>100</td><td>333.3 ± 58.6</td><td>3</td><td>310 ± 51.6</td><td>3</td><td>6.6 ± 3.0</td><td>2</td><td>9.1 ± 4.7</td><td>2</td></tr><tr><td>1000</td><td>ND</td><td></td><td>352 ± 55.5</td><td>3</td><td>ND</td><td></td><td>7.5 ± 7.5</td><td>2</td></tr><tr><td>10,000</td><td>ND</td><td></td><td>613 ± 58.7</td><td>3</td><td>ND</td><td></td><td>0 ± 0</td><td>2</td></tr><tr><td>100,000</td><td>ND</td><td></td><td>973.5 ± 264.5 *</td><td>2</td><td>ND</td><td></td><td>2.05 ± 2.05</td><td>2</td></tr></table>
a4387ae8e2afc2cb28086db0dbf096f8f595102fd891db733a30fc458297968e.png	complex	<table><tr><td colspan="2">Characteristics</td><td>Orifice involved (n=138)</td><td>Non-Orifice involved (n=1221)</td><td>Total (n=1359)</td><td>P</td></tr><tr><td colspan="2">Age (Mean ± SD)</td><td>65.1±10.5</td><td>63.4±11.7</td><td>63.5±11.6</td><td>0.087</td></tr><tr><td colspan="2">Follow-up, months (mean ± IQR)</td><td>45.5 (9–68)</td><td>47.1 (9–70)</td><td>46.9 (9–69)</td><td>0.721</td></tr><tr><td colspan="2">No. Gender (%)</td><td></td><td></td><td></td><td></td></tr><tr><td></td><td>M</td><td>119 (86.2)</td><td>1095 (89.7)</td><td>1214 (89.3)</td><td rowspan="2">0.214</td></tr><tr><td></td><td>F</td><td>19 (13.8)</td><td>126 (10.3)</td><td>145 (10.7)</td></tr><tr><td colspan="2">No.TCC tumor grade (%)</td><td></td><td></td><td></td><td></td></tr><tr><td></td><td>G1</td><td>47 (34.1)</td><td>493 (40.4)</td><td>540 (39.7)</td><td></td></tr><tr><td></td><td>G2</td><td>36 (26.1)</td><td>286 (23.4)</td><td>322 (23.7)</td><td rowspan="2">0.067</td></tr><tr><td></td><td>G3</td><td>40 (29.0)</td><td>248 (20.3)</td><td>288 (21.2)</td></tr><tr><td></td><td>Unspecified</td><td>15 (10.8)</td><td>194 (15.9)</td><td>209 (15.4)</td><td></td></tr><tr><td colspan="2">No.TCC Tumor stage (%)</td><td></td><td></td><td></td><td></td></tr><tr><td></td><td>Ta</td><td>47 (34.1)</td><td>349 (28.6)</td><td>396 (29.1)</td><td></td></tr><tr><td></td><td>T1</td><td>59 (42.8)</td><td>520 (42.6)</td><td>579 (42.6)</td><td rowspan="2">0.565</td></tr><tr><td></td><td>≥T2</td><td>32 (23.2)</td><td>302 (24.7)</td><td>334 (24.6)</td></tr><tr><td></td><td>Unspecified</td><td>–</td><td>50 (4.1)</td><td>50 (3.7)</td><td></td></tr><tr><td colspan="2">Carsinoma in situ (CIS)(%)</td><td></td><td></td><td></td><td></td></tr><tr><td></td><td>CIS at initial diagnosis</td><td>6 (4.3)</td><td>42 (3.4)</td><td>48 (3.5)</td><td>0.584</td></tr><tr><td></td><td>CIS progression</td><td>3 (2.2)</td><td>22 (1.8)</td><td>25 (1.8)</td><td>0.758</td></tr><tr><td></td><td>Total CIS</td><td>9 (6.5)</td><td>64 (5.2)</td><td>73 (5.3)</td><td></td></tr><tr><td colspan="2">No. Tumor size (%)</td><td></td><td></td><td></td><td></td></tr><tr><td></td><td>Tumor < 3 cm</td><td>35 (25.4)</td><td>348 (28.5)</td><td>383 (28.2)</td><td></td></tr><tr><td></td><td>Tumor ≥ 3 cm</td><td>94 (68.1)</td><td>755 (61.8)</td><td>849 (62.5)</td><td>0.305</td></tr><tr><td></td><td>Unspecified</td><td>9 (6.5)</td><td>118 (9.7)</td><td>127 (9.3)</td><td></td></tr><tr><td colspan="2">No. Tumor number (%)</td><td></td><td></td><td></td><td></td></tr><tr><td></td><td>Solitary</td><td>99 (71.7)</td><td>728 (59.6)</td><td>827 (60.9)</td><td></td></tr><tr><td></td><td>Multiple</td><td>36 (26.1)</td><td>479 (39.2)</td><td>515 (37.9)</td><td>0.003</td></tr><tr><td></td><td>Unspecified</td><td>3 (2.2)</td><td>14 (1.1)</td><td>17 (1.2)</td><td></td></tr><tr><td colspan="2">Hydronephrosis (initial diagnosis)(%)</td><td></td><td></td><td></td><td></td></tr><tr><td></td><td>Hydronephrosis±Atrophic kidney</td><td>46 (33.3)</td><td>170 (13.9)</td><td>216 (15.9)</td><td>0.0001</td></tr><tr><td colspan="2">Presence of UTUC (%)</td><td></td><td></td><td></td><td></td></tr><tr><td></td><td>Synchronous</td><td>14 (10.1)</td><td>8 (0.7)</td><td>22 (1.6)</td><td rowspan="2">0.0001</td></tr><tr><td></td><td>Metachronous</td><td>7 (5.3)</td><td>11 (0.9)</td><td>18 (1.4)</td></tr></table>	<table><tr><td colspan="2">Characteristics</td><td>Orifice involved (n=138)</td><td>Non-Orifice involved (n=1221)</td><td>Total (n=1359)</td></tr><tr><td colspan="2">Age (Mean ± SD)</td><td>65.1±10.5</td><td>63.4±11.7</td><td>63.5±11.6</td></tr><tr><td colspan="2">Follow-up, months (mean ± IQR)</td><td>45.5 (9–68)</td><td>47.1 (9–70)</td><td>46.9 (9–69)</td></tr><tr><td colspan="2">No. Gender (%)</td><td></td><td></td><td></td></tr><tr><td></td><td>M</td><td>119 (86.2)</td><td>1095 (89.7)</td><td>1214 (89.3)</td></tr><tr><td></td><td>F</td><td>19 (13.8)</td><td>126 (10.3)</td><td>145 (10.7)</td></tr><tr><td colspan="2">No.TCC tumor grade (%)</td><td></td><td></td><td></td></tr><tr><td></td><td>G1</td><td>47 (34.1)</td><td>493 (40.4)</td><td>540 (39.7)</td></tr><tr><td></td><td>G2</td><td>36 (26.1)</td><td>286 (23.4)</td><td>322 (23.7)</td></tr><tr><td></td><td>G3</td><td>40 (29.0)</td><td>248 (20.3)</td><td>288 (21.2)</td></tr><tr><td></td><td>Unspecified</td><td>15 (10.8)</td><td>194 (15.9)</td><td>209 (15.4)</td></tr><tr><td colspan="2">No.TCC Tumor stage (%)</td><td></td><td></td><td></td></tr><tr><td></td><td>Ta</td><td>47 (34.1)</td><td>349 (28.6)</td><td>396 (29.1)</td></tr><tr><td></td><td>T1</td><td>59 (42.8)</td><td>520 (42.6)</td><td>579 (42.6)</td></tr><tr><td></td><td>≥T2</td><td>32 (23.2)</td><td>302 (24.7)</td><td>334 (24.6)</td></tr><tr><td></td><td>Unspecified</td><td>–</td><td>50 (4.1)</td><td>50 (3.7)</td></tr><tr><td colspan="2">Carsinoma in situ (CIS)(%)</td><td></td><td></td><td></td></tr><tr><td></td><td>CIS at initial diagnosis</td><td>6 (4.3)</td><td>42 (3.4)</td><td>48 (3.5)</td></tr><tr><td></td><td>CIS progression</td><td>3 (2.2)</td><td>22 (1.8)</td><td>25 (1.8)</td></tr><tr><td></td><td>Total CIS</td><td>9 (6.5)</td><td>64 (5.2)</td><td>73 (5.3)</td></tr><tr><td colspan="2">No. Tumor size (%)</td><td></td><td></td><td></td></tr><tr><td></td><td>Tumor < 3 cm</td><td>35 (25.4)</td><td>348 (28.5)</td><td>383 (28.2)</td></tr><tr><td></td><td>Tumor ≥ 3 cm</td><td>94 (68.1)</td><td>755 (61.8)</td><td>849 (62.5)</td></tr><tr><td></td><td>Unspecified</td><td>9 (6.5)</td><td>118 (9.7)</td><td>127 (9.3)</td></tr><tr><td colspan="2">No. Tumor number (%)</td><td></td><td></td><td></td></tr><tr><td></td><td>Solitary</td><td>99 (71.7)</td><td>728 (59.6)</td><td>827 (60.9)</td></tr><tr><td></td><td>Multiple</td><td>36 (26.1)</td><td>479 (39.2)</td><td>515 (37.9)</td></tr><tr><td></td><td>Unspecified</td><td>3 (2.2)</td><td>14 (1.1)</td><td>17 (1.2)</td></tr><tr><td colspan="2">Hydronephrosis (initial diagnosis)(%)</td><td></td><td></td><td></td></tr><tr><td></td><td>Hydronephrosis±Atrophic kidney</td><td>46 (33.3)</td><td>170 (13.9)</td><td>216 (15.9)</td></tr><tr><td colspan="2">Presence of UTUC (%)</td><td></td><td></td><td></td></tr><tr><td></td><td>Synchronous</td><td>14 (10.1)</td><td>8 (0.7)</td><td>22 (1.6)</td></tr><tr><td></td><td>Metachronous</td><td>7 (5.3)</td><td>11 (0.9)</td><td>18 (1.4)</td></tr></table>	<table><tr><td>P</td></tr><tr><td>0.087</td></tr><tr><td>0.721</td></tr><tr><td></td></tr><tr><td rowspan="2">0.214</td></tr><tr></tr><tr><td></td></tr><tr><td></td></tr><tr><td rowspan="2">0.067</td></tr><tr></tr><tr><td></td></tr><tr><td></td></tr><tr><td></td></tr><tr><td rowspan="2">0.565</td></tr><tr></tr><tr><td></td></tr><tr><td></td></tr><tr><td>0.584</td></tr><tr><td>0.758</td></tr><tr><td></td></tr><tr><td></td></tr><tr><td></td></tr><tr><td>0.305</td></tr><tr><td></td></tr><tr><td></td></tr><tr><td></td></tr><tr><td>0.003</td></tr><tr><td></td></tr><tr><td></td></tr><tr><td>0.0001</td></tr><tr><td></td></tr><tr><td rowspan="2">0.0001</td></tr><tr></tr></table>
f6a1a42693b8d2c2a6159b0b9ff1852998db81a535a2c8fa272df325a3f59322.png	simple	<table><tr><td></td><td><i>E</i>/MPa</td><td><i>μ</i></td><td><i>α</i></td><td><i>K</i>/MPa</td></tr><tr><td>Theory values</td><td>2157</td><td>0.2</td><td>0.165872</td><td>0.875726</td></tr><tr><td>Identified values by GA</td><td>2135</td><td>0.182</td><td>0.171365</td><td>0.853471</td></tr><tr><td>Relative error of computing results for GA (%)</td><td>1.02</td><td>9</td><td>3.31</td><td>2.54</td></tr><tr><td>Identified values by FGA</td><td>2140</td><td>0.182</td><td>0.168442</td><td>0.853532</td></tr><tr><td>Relative error of computing results for FGA (%)</td><td>0.79</td><td>9</td><td>1.55</td><td>2.54</td></tr><tr><td>Identified values by IGA</td><td>2143</td><td>0.188</td><td>0.167812</td><td>0.854621</td></tr><tr><td>Relative error of computing results for IGA (%)</td><td>0.65</td><td>6</td><td>1.17</td><td>2.41</td></tr></table>	<table><tr><td></td><td>E/MPa</td><td>μ</td><td>α</td><td>K/MPa</td></tr><tr><td>Theory values</td><td>2157</td><td>0.2</td><td>0.165872</td><td>0.875726</td></tr><tr><td>Identified values by GA</td><td>2135</td><td>0.182</td><td>0.171365</td><td>0.853471</td></tr><tr><td>Relative error of computing results for GA (%)</td><td>1.02</td><td>9</td><td>3.31</td><td>2.54</td></tr><tr><td>Identified values by FGA</td><td>2140</td><td>0.182</td><td>0.168442</td><td>0.853532</td></tr><tr><td>Relative error of computing results for FGA (%)</td><td>0.79</td><td>9</td><td>1.55</td><td>2.54</td></tr><tr><td>Identified values by IGA</td><td>2143</td><td>0.188</td><td>0.167812</td><td>0.854621</td></tr></table>	<table><tr><td></td><td>E/MPa</td><td>μ</td><td>α</td><td>K/MPa</td></tr><tr><td>Relative error of computing results for IGA (%)</td><td>0.65</td><td>6</td><td>1.17</td><td>2.41</td></tr></table>
084c7534c7cd4e5cabc9061a5dddba6c51f1ccf289662293bb6764b32cd8543e.png	complex	<table><tr><td>TOOL</td><td colspan="6">COHORT CHARACTERISTICS</td></tr><tr><td> </td><td>Disease</td><td>Number</td><td>Age (years)</td><td>Time since diagnosis/transplant</td><td>Race & gender</td><td>Country of validation</td></tr><tr><td>TRAQ [4]</td><td>Chronic diseases</td><td>192</td><td>16-26 (mean: 19.7)</td><td>NR</td><td>64% white, 56% female</td><td>USA</td></tr><tr><td>UNCTRxANSITION [17]</td><td>Chronic diseases</td><td>NR</td><td>12-22</td><td>NR</td><td>NR</td><td>USA</td></tr><tr><td>Self-management skills assessment guide [16]</td><td>Chronic diseases</td><td>49</td><td>11-19 (mean: 15.6)</td><td>NR</td><td>86% Caucasian</td><td>Canada</td></tr><tr><td>SCIS [8]</td><td>CF (with pancreatic insufficiency)</td><td>76 patients, 70 parents</td><td>4-17 (mean: 11.2)</td><td>NR</td><td>94% white</td><td>USA</td></tr><tr><td>Readiness questionnaire [9]</td><td>CF</td><td>36</td><td>NR</td><td>NR</td><td>NR</td><td>Canada</td></tr><tr><td>RTQ [10]</td><td>Renal transplant</td><td>48 patients, 32 parents</td><td>15-21 (mean: 18.6)</td><td>5.73 y</td><td>58% white, 29% black, 10% Hispanic</td><td>USA</td></tr><tr><td>TRS [2]</td><td>Liver transplant</td><td>71 patients, 58 parents</td><td>11-20 (mean: 15.6)</td><td>1-19 y (mean: 9.4 y)</td><td>56% female</td><td>USA</td></tr><tr><td>RCBRS [13]</td><td>T1DM</td><td>69</td><td>12-17 (mean: 14.2)</td><td>>6 months (mean: 5.49)</td><td>87% Caucasian</td><td>USA</td></tr><tr><td>McPherson et al. [14]</td><td>Sickle cell disease</td><td>69</td><td>14-21</td><td>NR</td><td>43% female</td><td>USA</td></tr><tr><td>TRQ [15]</td><td>HIV</td><td>65</td><td>9-25 (mean: 15.8)</td><td>1-17 years (mean: 10.5)</td><td>44% female, 45% Caucasian</td><td>USA</td></tr></table>	<table><tr><td>TOOL</td><td colspan="6">COHORT CHARACTERISTICS</td></tr></table>	<table><tr><td></td><td>Disease</td><td>Number</td><td>Age (years)</td><td>Time since diagnosis/transplant</td><td>Race & gender</td><td>Country of validation</td></tr><tr><td>TRAQ [4]</td><td>Chronic diseases</td><td>192</td><td>16-26 (mean: 19.7)</td><td>NR</td><td>64% white, 56% female</td><td>USA</td></tr><tr><td>UNCTRxANSITION [17]</td><td>Chronic diseases</td><td>NR</td><td>12-22</td><td>NR</td><td>NR</td><td>USA</td></tr><tr><td>Self-management skills assessment guide [16]</td><td>Chronic diseases</td><td>49</td><td>11-19 (mean: 15.6)</td><td>NR</td><td>86% Caucasian</td><td>Canada</td></tr><tr><td>SCIS [8]</td><td>CF (with pancreatic insufficiency)</td><td>76 patients, 70 parents</td><td>4-17 (mean: 11.2)</td><td>NR</td><td>94% white</td><td>USA</td></tr><tr><td>Readiness questionnaire [9]</td><td>CF</td><td>36</td><td>NR</td><td>NR</td><td>NR</td><td>Canada</td></tr><tr><td>RTQ [10]</td><td>Renal transplant</td><td>48 patients, 32 parents</td><td>15-21 (mean: 18.6)</td><td>5.73 y</td><td>58% white, 29% black, 10% Hispanic</td><td>USA</td></tr><tr><td>TRS [2]</td><td>Liver transplant</td><td>71 patients, 58 parents</td><td>11-20 (mean: 15.6)</td><td>1-19 y (mean: 9.4 y)</td><td>56% female</td><td>USA</td></tr><tr><td>RCBRS [13]</td><td>T1DM</td><td>69</td><td>12-17 (mean: 14.2)</td><td>>6 months (mean: 5.49)</td><td>87% Caucasian</td><td>USA</td></tr><tr><td>McPherson et al. [14]</td><td>Sickle cell disease</td><td>69</td><td>14-21</td><td>NR</td><td>43% female</td><td>USA</td></tr><tr><td>TRQ [15]</td><td>HIV</td><td>65</td><td>9-25 (mean: 15.8)</td><td>1-17 years (mean: 10.5)</td><td>44% female, 45% Caucasian</td><td>USA</td></tr></table>
fbcbde448d680a7d68352ef2dd7c6bec922a4fbdb6249c4998571a1c7c0fd98a.png	complex	<table><tr><td colspan="10">Phase II study</td></tr><tr><td rowspan="2">Patient</td><td rowspan="2">Treatment group</td><td colspan="8">Visit</td></tr><tr><td>BL</td><td>C2D1</td><td>C3D1</td><td>C4D1</td><td>D85</td><td>D180</td><td>D360</td><td>ET</td></tr><tr><td><i>1</i></td><td><i>Lipegfilgrastim</i></td><td><i>Neg</i></td><td><i>Neg</i></td><td><i>Neg</i></td><td><i>Neg</i></td><td><i>Pos</i></td><td><i>NA</i></td><td><i>NA</i></td><td><i>NA</i></td></tr><tr><td><i>2</i></td><td><i>Lipegfilgrastim</i></td><td><i>NA</i></td><td><i>NA</i></td><td><i>NA</i></td><td><i>NA</i></td><td><i>NA</i></td><td><i>NA</i></td><td><i>Pos</i></td><td><i>NA</i></td></tr><tr><td>3</td><td>Lipegfilgrastim</td><td>Pos</td><td>Pos</td><td>Pos</td><td>Pos</td><td>Pos</td><td>Pos</td><td>Pos</td><td>NA</td></tr><tr><td>4</td><td>Lipegfilgrastim</td><td>Pos</td><td>Pos</td><td>Pos</td><td>Pos</td><td>Pos</td><td>Pos</td><td>Neg</td><td>NA</td></tr><tr><td>5</td><td>Lipegfilgrastim</td><td>Pos</td><td>Pos</td><td>NA</td><td>NA</td><td>NA</td><td>Pos</td><td>Pos</td><td>Neg</td></tr><tr><td>6</td><td>Lipegfilgrastim</td><td>Pos</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td></tr><tr><td>7</td><td>Lipegfilgrastim</td><td>Pos</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td></tr><tr><td>8</td><td>Lipegfilgrastim</td><td>Pos</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>Neg</td><td>NA</td></tr><tr><td>9</td><td>Lipegfilgrastim</td><td>Pos</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td></tr><tr><td><i>10</i></td><td><i>Pegfilgrastim</i></td><td><i>NA</i></td><td><i>NA</i></td><td><i>NA</i></td><td><i>NA</i></td><td><i>Pos</i></td><td><i>NA</i></td><td><i>NA</i></td><td><i>NA</i></td></tr><tr><td>11</td><td>Pegfilgrastim</td><td>Pos</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td></tr><tr><td>12</td><td>Pegfilgrastim</td><td>Pos</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td></tr><tr><td colspan="10">Phase III study</td></tr><tr><td rowspan="2">Patient</td><td rowspan="2">Treatment group</td><td colspan="8">Visit</td></tr><tr><td>S</td><td>BL</td><td>C2D1</td><td>C3D1</td><td>C4D1</td><td>D85</td><td>D180</td><td>D360</td></tr><tr><td><i>13</i></td><td><i>Lipegfilgrastim</i></td><td><i>NA</i></td><td><i>NA</i></td><td><i>NA</i></td><td><i>NA</i></td><td><i>NA</i></td><td><i>NA</i></td><td><i>Pos</i></td><td><i>Pos</i></td></tr><tr><td>14</td><td>Lipegfilgrastim</td><td>NA</td><td>Pos</td><td>Pos</td><td>Pos</td><td>Pos</td><td>Neg</td><td>Neg</td><td>Neg</td></tr><tr><td>15</td><td>Lipegfilgrastim</td><td>NA</td><td>Pos</td><td>Pos</td><td>Neg</td><td>Neg</td><td>Neg</td><td>Neg</td><td>Neg</td></tr><tr><td>16</td><td>Lipegfilgrastim</td><td>NA</td><td>Pos</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td></tr><tr><td><i>17</i></td><td><i>Pegfilgrastim</i></td><td><i>NA</i></td><td><i>NA</i></td><td><i>NA</i></td><td><i>NA</i></td><td><i>NA</i></td><td><i>NA</i></td><td><i>NA</i></td><td><i>Pos</i></td></tr><tr><td>18</td><td>Pegfilgrastim</td><td>NA</td><td>Pos</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td></tr><tr><td>19</td><td>Pegfilgrastim</td><td>Pos</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td></tr><tr><td>20</td><td>Pegfilgrastim</td><td>NA</td><td>Pos</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td></tr><tr><td>21</td><td>Pegfilgrastim</td><td>NA</td><td>Pos</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td></tr><tr><td>22</td><td>Pegfilgrastim</td><td>NA</td><td>Pos</td><td>Neg</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td></tr><tr><td>23</td><td>Pegfilgrastim</td><td>NA</td><td>Pos</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td></tr></table>	<table><tr><td colspan="10">Phase II study</td></tr><tr><td rowspan="2">Patient</td><td rowspan="2">Treatment group</td><td colspan="8">Visit</td></tr><tr><td>BL</td><td>C2D1</td><td>C3D1</td><td>C4D1</td><td>D85</td><td>D180</td><td>D360</td><td>ET</td></tr><tr><td>1</td><td>Lipegfilgrastim</td><td>Neg</td><td>Neg</td><td>Neg</td><td>Neg</td><td>Pos</td><td>NA</td><td>NA</td><td>NA</td></tr><tr><td>2</td><td>Lipegfilgrastim</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>Pos</td><td>NA</td></tr><tr><td>3</td><td>Lipegfilgrastim</td><td>Pos</td><td>Pos</td><td>Pos</td><td>Pos</td><td>Pos</td><td>Pos</td><td>Pos</td><td>NA</td></tr><tr><td>4</td><td>Lipegfilgrastim</td><td>Pos</td><td>Pos</td><td>Pos</td><td>Pos</td><td>Pos</td><td>Pos</td><td>Neg</td><td>NA</td></tr><tr><td>5</td><td>Lipegfilgrastim</td><td>Pos</td><td>Pos</td><td>NA</td><td>NA</td><td>NA</td><td>Pos</td><td>Pos</td><td>Neg</td></tr><tr><td>6</td><td>Lipegfilgrastim</td><td>Pos</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td></tr><tr><td>7</td><td>Lipegfilgrastim</td><td>Pos</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td></tr><tr><td>8</td><td>Lipegfilgrastim</td><td>Pos</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>Neg</td><td>NA</td></tr><tr><td>9</td><td>Lipegfilgrastim</td><td>Pos</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td></tr><tr><td>10</td><td>Pegfilgrastim</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>Pos</td><td>NA</td><td>NA</td><td>NA</td></tr><tr><td>11</td><td>Pegfilgrastim</td><td>Pos</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td></tr><tr><td>12</td><td>Pegfilgrastim</td><td>Pos</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td></tr><tr><td colspan="10">Phase III study</td></tr><tr><td rowspan="2">Patient</td><td rowspan="2">Treatment group</td><td colspan="8">Visit</td></tr><tr><td>S</td><td>BL</td><td>C2D1</td><td>C3D1</td><td>C4D1</td><td>D85</td><td>D180</td><td>D360</td></tr><tr><td>13</td><td>Lipegfilgrastim</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>Pos</td><td>Pos</td></tr><tr><td>14</td><td>Lipegfilgrastim</td><td>NA</td><td>Pos</td><td>Pos</td><td>Pos</td><td>Pos</td><td>Neg</td><td>Neg</td><td>Neg</td></tr><tr><td>15</td><td>Lipegfilgrastim</td><td>NA</td><td>Pos</td><td>Pos</td><td>Neg</td><td>Neg</td><td>Neg</td><td>Neg</td><td>Neg</td></tr><tr><td>16</td><td>Lipegfilgrastim</td><td>NA</td><td>Pos</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td></tr><tr><td>17</td><td>Pegfilgrastim</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>Pos</td></tr></table>	<table><tr><td colspan="10">Phase II study</td></tr><tr><td rowspan="2">Patient</td><td rowspan="2">Treatment group</td><td colspan="8">Visit</td></tr><tr><td>BL</td><td>C2D1</td><td>C3D1</td><td>C4D1</td><td>D85</td><td>D180</td><td>D360</td><td>ET</td></tr><tr><td>18</td><td>Pegfilgrastim</td><td>NA</td><td>Pos</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td></tr><tr><td>19</td><td>Pegfilgrastim</td><td>Pos</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td></tr><tr><td>20</td><td>Pegfilgrastim</td><td>NA</td><td>Pos</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td></tr><tr><td>21</td><td>Pegfilgrastim</td><td>NA</td><td>Pos</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td></tr><tr><td>22</td><td>Pegfilgrastim</td><td>NA</td><td>Pos</td><td>Neg</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td></tr><tr><td>23</td><td>Pegfilgrastim</td><td>NA</td><td>Pos</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td><td>NA</td></tr></table>
6bdd9b5e161bbf04a34227f1215b45d2b05308acae181ec60c1c56fe7152a32b.png	complex	<table><tr><td rowspan="3">Birth Weight for Gestational Age</td><td colspan="6">Dietary Pattern</td></tr><tr><td>Cereals, Eggs, and Cantonese Soups</td><td>Dairy</td><td>Fruits, Nuts, and Cantonese Desserts</td><td>Meats</td><td>Vegetables</td><td>Varied</td></tr><tr><td>(<i>n</i> = 1026)</td><td>(<i>n</i> = 1020)</td><td>(<i>n</i> = 799)</td><td>(<i>n</i> = 1066)</td><td>(<i>n</i> = 1383)</td><td>(<i>n</i> = 1160)</td></tr><tr><td>SGA (n, %)</td><td>89 (8.7)</td><td>80 (7.8)</td><td>54 (6.8)</td><td>86 (8.1)</td><td>94 (6.8)</td><td>102 (6.1)</td></tr><tr><td> Crude OR (95% CI)</td><td>1.00 (Reference)</td><td>0.90 (0.65-1.23)</td><td>0.76 (0.54-1.08)</td><td>0.92 (0.68-1.26)</td><td>0.77 (0.57-1.04)</td><td>0.69 (0.51-0.93) </td></tr><tr><td> Adjusted OR (95% CI) <sup>1</sup></td><td>1.00 (Reference)</td><td>0.89 (0.65-1.22)</td><td>0.80 (0.56-1.14)</td><td>0.94 (0.69-1.28)</td><td>0.78 (0.58-1.06)</td><td>0.75 (0.56-1.01) </td></tr><tr><td> Adjusted OR (95% CI) <sup>2</sup></td><td>1.00 (Reference)</td><td>0.90 (0.66-1.23)</td><td>0.77 (0.54-1.09)</td><td>0.92 (0.68-1.26)</td><td>0.77 (0.57-1.04)</td><td>0.69 (0.51-0.93) </td></tr><tr><td> Adjusted OR (95% CI) <sup>3</sup></td><td>1.00 (Reference)</td><td>0.89 (0.65-1.23)</td><td>0.72 (0.50-1.03)</td><td>0.94 (0.69-1.29)</td><td>0.76 (0.56-1.04)</td><td>0.70 (0.52-0.95) *</td></tr><tr><td> Adjusted OR (95% CI) <sup>4</sup></td><td>1.00 (Reference)</td><td>0.87 (0.63-1.21)</td><td>0.76 (0.53-1.10)</td><td>0.95 (0.69-1.30)</td><td>0.77 (0.56-1.05)</td><td>0.77 (0.57-1.04)</td></tr><tr><td>LGA (n, %)</td><td>103 (10.0)</td><td>106 (10.4)</td><td>96 (12.0)</td><td>87 (8.2)</td><td>147 (10.6)</td><td>194 (11.7)</td></tr><tr><td> Crude OR (95% CI)</td><td>1.00 (Reference)</td><td>1.04 (0.78-1.38)</td><td>1.22 (0.91-1.64)</td><td>0.80 (0.59-1.07)</td><td>1.07 (0.82-1.39)</td><td>1.19 (0.92-1.53)</td></tr><tr><td> Adjusted OR (95% CI) <sup>1</sup></td><td>1.00 (Reference)</td><td>1.03 (0.78-1.38)</td><td>1.17 (0.87-1.57)</td><td>0.78 (0.58-1.06)</td><td>1.04 (0.80-1.36)</td><td>1.11 (0.86-1.43)</td></tr><tr><td> Adjusted OR (95% CI) <sup>2</sup></td><td>1.00 (Reference)</td><td>1.03 (0.77-1.37)</td><td>1.21 (0.90-1.62)</td><td>0.79 (0.59-1.07)</td><td>1.08 (0.82-1.41)</td><td>1.19 (0.93-1.54)</td></tr><tr><td> Adjusted OR (95% CI) <sup>3</sup></td><td>1.00 (Reference)</td><td>1.04 (0.77-1.36)</td><td>1.22 (0.90-1.64)</td><td>0.77 (0.57-1.04)</td><td>1.06 (0.81-1.38)</td><td>1.17 (0.91-1.51)</td></tr><tr><td> Adjusted OR (95% CI) <sup>4</sup></td><td>1.00 (Reference)</td><td>1.01 (0.75-1.35)</td><td>1.14 (0.84-1.54)</td><td>0.75 (0.56-1.02) </td><td>1.03 (0.79-1.36)</td><td>1.10 (0.85-1.42)</td></tr></table>	<table><tr><td rowspan="3">Birth Weight for Gestational Age</td><td colspan="6">Dietary Pattern</td></tr><tr><td>Cereals, Eggs, and Cantonese Soups</td><td>Dairy</td><td>Fruits, Nuts, and Cantonese Desserts</td><td>Meats</td><td>Vegetables</td><td>Varied</td></tr><tr><td>(n = 1026)</td><td>(n = 1020)</td><td>(n = 799)</td><td>(n = 1066)</td><td>(n = 1383)</td><td>(n = 1160)</td></tr><tr><td>SGA (n, %)</td><td>89 (8.7)</td><td>80 (7.8)</td><td>54 (6.8)</td><td>86 (8.1)</td><td>94 (6.8)</td><td>102 (6.1)</td></tr><tr><td>Crude OR (95% CI)</td><td>1.00 (Reference)</td><td>0.90 (0.65-1.23)</td><td>0.76 (0.54-1.08)</td><td>0.92 (0.68-1.26)</td><td>0.77 (0.57-1.04)</td><td>0.69 (0.51-0.93) *</td></tr></table>	<table><tr><td rowspan="3">Birth Weight for Gestational Age</td><td colspan="6">Dietary Pattern</td></tr><tr><td>Cereals, Eggs, and Cantonese Soups</td><td>Dairy</td><td>Fruits, Nuts, and Cantonese Desserts</td><td>Meats</td><td>Vegetables</td><td>Varied</td></tr><tr><td>(n = 1026)</td><td>(n = 1020)</td><td>(n = 799)</td><td>(n = 1066)</td><td>(n = 1383)</td><td>(n = 1160)</td></tr><tr><td>Adjusted OR (95% CI) 1</td><td>1.00 (Reference)</td><td>0.89 (0.65-1.22)</td><td>0.80 (0.56-1.14)</td><td>0.94 (0.69-1.28)</td><td>0.78 (0.58-1.06)</td><td>0.75 (0.56-1.01)</td></tr><tr><td>Adjusted OR (95% CI) 2</td><td>1.00 (Reference)</td><td>0.90 (0.66-1.23)</td><td>0.77 (0.54-1.09)</td><td>0.92 (0.68-1.26)</td><td>0.77 (0.57-1.04)</td><td>0.69 (0.51-0.93) </td></tr><tr><td>Adjusted OR (95% CI) 3</td><td>1.00 (Reference)</td><td>0.89 (0.65-1.23)</td><td>0.72 (0.50-1.03)</td><td>0.94 (0.69-1.29)</td><td>0.76 (0.56-1.04)</td><td>0.70 (0.52-0.95) </td></tr><tr><td>Adjusted OR (95% CI) 4</td><td>1.00 (Reference)</td><td>0.87 (0.63-1.21)</td><td>0.76 (0.53-1.10)</td><td>0.95 (0.69-1.30)</td><td>0.77 (0.56-1.05)</td><td>0.77 (0.57-1.04)</td></tr><tr><td>LGA (n, %)</td><td>103 (10.0)</td><td>106 (10.4)</td><td>96 (12.0)</td><td>87 (8.2)</td><td>147 (10.6)</td><td>194 (11.7)</td></tr><tr><td>Crude OR (95% CI)</td><td>1.00 (Reference)</td><td>1.04 (0.78-1.38)</td><td>1.22 (0.91-1.64)</td><td>0.80 (0.59-1.07)</td><td>1.07 (0.82-1.39)</td><td>1.19 (0.92-1.53)</td></tr><tr><td>Adjusted OR (95% CI) 1</td><td>1.00 (Reference)</td><td>1.03 (0.78-1.38)</td><td>1.17 (0.87-1.57)</td><td>0.78 (0.58-1.06)</td><td>1.04 (0.80-1.36)</td><td>1.11 (0.86-1.43)</td></tr><tr><td>Adjusted OR (95% CI) 2</td><td>1.00 (Reference)</td><td>1.03 (0.77-1.37)</td><td>1.21 (0.90-1.62)</td><td>0.79 (0.59-1.07)</td><td>1.08 (0.82-1.41)</td><td>1.19 (0.93-1.54)</td></tr><tr><td>Adjusted OR (95% CI) 3</td><td>1.00 (Reference)</td><td>1.04 (0.77-1.36)</td><td>1.22 (0.90-1.64)</td><td>0.77 (0.57-1.04)</td><td>1.06 (0.81-1.38)</td><td>1.17 (0.91-1.51)</td></tr><tr><td>Adjusted OR (95% CI) 4</td><td>1.00 (Reference)</td><td>1.01 (0.75-1.35)</td><td>1.14 (0.84-1.54)</td><td>0.75 (0.56-1.02)</td><td>1.03 (0.79-1.36)</td><td>1.10 (0.85-1.42)</td></tr></table>
f19782f1f8947e4c27ab993149e238697b050b5c8f4d61d51354213a55008b3e.png	complex	<table><tr><td rowspan="2">mRNA co-expression MET vs.</td><td colspan="2">ALL Stage</td><td colspan="2">Stage I-II</td><td colspan="2">Stage III-IV</td></tr><tr><td>Pearson's Correlation</td><td><i>p</i>-value</td><td>Pearson's Correlation</td><td><i>p</i>-value</td><td>Pearson's Correlation</td><td><i>p</i>-value</td></tr><tr><td><i>ALDH1A1</i></td><td>0.06</td><td>0.008</td><td>0.05</td><td>0.058</td><td>-0.03</td><td>0.736</td></tr><tr><td><i>ALDH1A3</i></td><td>0.22</td><td><0.001</td><td>0.21</td><td><0.001</td><td>0.40</td><td><0.001</td></tr><tr><td><i>CD44</i></td><td>0.02</td><td>0.381</td><td>0.01</td><td>0.857</td><td>0.04</td><td>0.637</td></tr><tr><td><i>CD133</i></td><td>0.30</td><td><0.001</td><td>0.31</td><td><0.001</td><td>0.40</td><td><0.001</td></tr><tr><td><i>KLF4</i></td><td>0.10</td><td><0.001</td><td>0.11</td><td><0.001</td><td>0.12</td><td>0.181</td></tr><tr><td><i>MYC</i></td><td>0.14</td><td><0.001</td><td>0.15</td><td><0.001</td><td>0.17</td><td>0.055</td></tr><tr><td><i>NANOG</i></td><td>-0.04</td><td>0.064</td><td>-0.02</td><td>0.560</td><td>0.01</td><td>0.895</td></tr><tr><td><i>NOTCH1</i></td><td>0.17</td><td><0.001</td><td>0.16</td><td><0.001</td><td>0.43</td><td><0.001</td></tr><tr><td><i>NOTCH3</i></td><td>0.06</td><td>0.010</td><td>0.02</td><td>0.449</td><td>0.22</td><td>0.017</td></tr><tr><td><i>OCT4</i></td><td>0.02</td><td>0.325</td><td>0.00</td><td>0.888</td><td>0.35</td><td><0.001</td></tr><tr><td><i>SOX2</i></td><td>0.00</td><td>0.882</td><td>0.01</td><td>0.730</td><td>-0.05</td><td>0.609</td></tr><tr><td><i>STAT3</i></td><td>-0.03</td><td>0.156</td><td>-0.05</td><td>0.078</td><td>-0.05</td><td>0.558</td></tr><tr><td><i>BMI1</i></td><td>-0.16</td><td><0.001</td><td>-0.17</td><td><0.001</td><td>-0.20</td><td>0.023</td></tr></table>	<table><tr><td rowspan="2">mRNA co-expression MET vs.</td><td colspan="2">ALL Stage</td><td colspan="2">Stage I-II</td><td colspan="2">Stage III-IV</td></tr><tr><td>Pearson's Correlation</td><td>p-value</td><td>Pearson's Correlation</td><td>p-value</td><td>Pearson's Correlation</td><td>p-value</td></tr><tr><td>ALDH1A1</td><td>0.06</td><td>0.008</td><td>0.05</td><td>0.058</td><td>-0.03</td><td>0.736</td></tr><tr><td>ALDH1A3</td><td>0.22</td><td><0.001</td><td>0.21</td><td><0.001</td><td>0.40</td><td><0.001</td></tr><tr><td>CD44</td><td>0.02</td><td>0.381</td><td>0.01</td><td>0.857</td><td>0.04</td><td>0.637</td></tr></table>	<table><tr><td>CD133</td><td>0.30</td><td><0.001</td><td>0.31</td><td><0.001</td><td>0.40</td><td><0.001</td></tr><tr><td>KLF4</td><td>0.10</td><td><0.001</td><td>0.11</td><td><0.001</td><td>0.12</td><td>0.181</td></tr><tr><td>MYC</td><td>0.14</td><td><0.001</td><td>0.15</td><td><0.001</td><td>0.17</td><td>0.055</td></tr><tr><td>NANOG</td><td>-0.04</td><td>0.064</td><td>-0.02</td><td>0.560</td><td>0.01</td><td>0.895</td></tr><tr><td>NOTCH1</td><td>0.17</td><td><0.001</td><td>0.16</td><td><0.001</td><td>0.43</td><td><0.001</td></tr><tr><td>NOTCH3</td><td>0.06</td><td>0.010</td><td>0.02</td><td>0.449</td><td>0.22</td><td>0.017</td></tr><tr><td>OCT4</td><td>0.02</td><td>0.325</td><td>0.00</td><td>0.888</td><td>0.35</td><td><0.001</td></tr><tr><td>SOX2</td><td>0.00</td><td>0.882</td><td>0.01</td><td>0.730</td><td>-0.05</td><td>0.609</td></tr><tr><td>STAT3</td><td>-0.03</td><td>0.156</td><td>-0.05</td><td>0.078</td><td>-0.05</td><td>0.558</td></tr><tr><td>BMI1</td><td>-0.16</td><td><0.001</td><td>-0.17</td><td><0.001</td><td>-0.20</td><td>0.023</td></tr></table>
f2c045feb4c0d601e6c9d8050f1ff9426cc921916c0c7812a586600fcf67c8b8.png	simple	<table><tr><td>Main objectives of participating in the training</td><td>n</td><td>%</td></tr><tr><td>To learn about psychosomatic medicine/biopsychosocial models</td><td>28</td><td>25%</td></tr><tr><td>To learn didactical teaching methods (such as interactive learning and presenting lectures)</td><td>23</td><td>20%</td></tr><tr><td>To acquire practical skills for daily clinical practice (such as communication, role playing, patient interviewing, family interviewing, and creating genograms)</td><td>18</td><td>16%</td></tr><tr><td>To learn about doctor-patient communication skills</td><td>12</td><td>11%</td></tr><tr><td>To improve patient management</td><td>9</td><td>8%</td></tr><tr><td>To learn about the diagnosis and treatment of specific psychosomatic disorders</td><td>8</td><td>6%</td></tr><tr><td>To address administrative and sustainability issues in the curriculum</td><td>5</td><td>4%</td></tr><tr><td>To learn how to use Balint group methods</td><td>5</td><td>4%</td></tr><tr><td>To share experiences with other doctors/acquire more self-experience</td><td>4</td><td>3%</td></tr><tr><td>Other</td><td>2</td><td>2%</td></tr></table>	<table><tr><td>Main objectives of participating in the training</td><td>n</td><td>%</td></tr><tr><td>To learn about psychosomatic medicine/biopsychosocial models</td><td>28</td><td>25%</td></tr><tr><td>To learn didactical teaching methods (such as interactive learning and presenting lectures)</td><td>23</td><td>20%</td></tr><tr><td>To acquire practical skills for daily clinical practice (such as communication, role playing, patient interviewing, family interviewing, and creating genograms)</td><td>18</td><td>16%</td></tr><tr><td>To learn about doctor-patient communication skills</td><td>12</td><td>11%</td></tr><tr><td>To improve patient management</td><td>9</td><td>8%</td></tr></table>	<table><tr><td>Main objectives of participating in the training</td><td>n</td><td>%</td></tr><tr><td>To learn about the diagnosis and treatment of specific psychosomatic disorders</td><td>8</td><td>6%</td></tr><tr><td>To address administrative and sustainability issues in the curriculum</td><td>5</td><td>4%</td></tr><tr><td>To learn how to use Balint group methods</td><td>5</td><td>4%</td></tr><tr><td>To share experiences with other doctors/acquire more self-experience</td><td>4</td><td>3%</td></tr><tr><td>Other</td><td>2</td><td>2%</td></tr></table>
0be0175547bca70f32887bc3e8d2b2b1cfbaaf899818fed20c0ccb93d24ac648.png	complex	<table><tr><td></td><td colspan="2">Intervention, n = 114</td><td colspan="2">Comparison, n = 60</td></tr><tr><td>IPV status</td><td>n</td><td>%</td><td>n</td><td>%</td></tr><tr><td>0</td><td>9</td><td><i>8</i></td><td>6</td><td><i>10</i></td></tr><tr><td>3–6</td><td>11</td><td><i>10</i></td><td>2</td><td><i>3</i></td></tr><tr><td>≥ 7</td><td>93</td><td><i>82</i></td><td>48</td><td><i>80</i></td></tr><tr><td>Missing</td><td>1</td><td><i>1</i></td><td>4</td><td><i>7</i></td></tr><tr><td>When partner last inflicted abuse</td><td></td><td></td><td></td><td></td></tr><tr><td> <i>Abused in last 12 months</i><i>(n = 121)</i></td><td></td><td></td><td></td><td></td></tr><tr><td>0</td><td>1</td><td><i>1</i></td><td>0</td><td><i>0</i></td></tr><tr><td>3–6</td><td>3</td><td><i>4</i></td><td>1</td><td><i>2</i></td></tr><tr><td>≥ 7</td><td>76</td><td><i>95</i></td><td>39</td><td><i>95</i></td></tr><tr><td>Missing</td><td>0</td><td><i>0</i></td><td>1</td><td><i>2</i></td></tr><tr><td> <i>Abused>12 months ago </i><i>(n = 33)</i></td><td></td><td></td><td></td><td></td></tr><tr><td>0</td><td>4</td><td><i>20</i></td><td>3</td><td><i>23</i></td></tr><tr><td>3–6</td><td><i>3</i></td><td><i>15</i></td><td>0</td><td><i>0</i></td></tr><tr><td>≥ 7</td><td>13</td><td><i>65</i></td><td>8</td><td><i>62</i></td></tr><tr><td>Missing</td><td><i>0</i></td><td><i>0</i></td><td>2</td><td><i>15</i></td></tr><tr><td> <i>A partner has never abused me</i><i>(n = 15)</i></td><td></td><td></td><td></td><td></td></tr><tr><td>0</td><td>4</td><td><i>36</i></td><td>2</td><td><i>50</i></td></tr><tr><td>3–6</td><td>2</td><td><i>18</i></td><td>1</td><td><i>25</i></td></tr><tr><td>≥ 7</td><td>4</td><td><i>36</i></td><td>0</td><td><i>0</i></td></tr><tr><td>Missing</td><td>1</td><td><i>9</i></td><td>1</td><td><i>25</i></td></tr><tr><td>Depressed (EPDS ≥ 13)</td><td></td><td></td><td></td><td></td></tr><tr><td>No</td><td>32</td><td><i>28</i></td><td>26</td><td><i>43</i></td></tr><tr><td>Yes</td><td>81</td><td><i>71</i></td><td>33</td><td><i>55</i></td></tr><tr><td>Missing</td><td>1</td><td></td><td>1</td><td></td></tr></table>	<table><tr><td></td><td colspan="2">Intervention, n = 114</td><td colspan="2">Comparison, n = 60</td></tr><tr><td>IPV status</td><td>n</td><td>%</td><td>n</td><td>%</td></tr><tr><td>0</td><td>9</td><td>8</td><td>6</td><td>10</td></tr><tr><td>3–6</td><td>11</td><td>10</td><td>2</td><td>3</td></tr><tr><td>≥ 7</td><td>93</td><td>82</td><td>48</td><td>80</td></tr><tr><td>Missing</td><td>1</td><td>1</td><td>4</td><td>7</td></tr><tr><td>When partner last inflicted abuse</td><td></td><td></td><td></td><td></td></tr><tr><td>Abused in last 12 months(n = 121)</td><td></td><td></td><td></td><td></td></tr><tr><td>0</td><td>1</td><td>1</td><td>0</td><td>0</td></tr><tr><td>3–6</td><td>3</td><td>4</td><td>1</td><td>2</td></tr></table>	<table><tr><td>≥ 7</td><td>76</td><td>95</td><td>39</td><td>95</td></tr><tr><td>Missing</td><td>0</td><td>0</td><td>1</td><td>2</td></tr><tr><td>Abused>12 months ago (n = 33)</td><td></td><td></td><td></td><td></td></tr><tr><td>0</td><td>4</td><td>20</td><td>3</td><td>23</td></tr><tr><td>3–6</td><td>3</td><td>15</td><td>0</td><td>0</td></tr><tr><td>≥ 7</td><td>13</td><td>65</td><td>8</td><td>62</td></tr><tr><td>Missing</td><td>0</td><td>0</td><td>2</td><td>15</td></tr><tr><td>A partner has never abused me(n = 15)</td><td></td><td></td><td></td><td></td></tr><tr><td>0</td><td>4</td><td>36</td><td>2</td><td>50</td></tr><tr><td>3–6</td><td>2</td><td>18</td><td>1</td><td>25</td></tr><tr><td>≥ 7</td><td>4</td><td>36</td><td>0</td><td>0</td></tr><tr><td>Missing</td><td>1</td><td>9</td><td>1</td><td>25</td></tr><tr><td>Depressed (EPDS ≥ 13)</td><td></td><td></td><td></td><td></td></tr><tr><td>No</td><td>32</td><td>28</td><td>26</td><td>43</td></tr><tr><td>Yes</td><td>81</td><td>71</td><td>33</td><td>55</td></tr><tr><td>Missing</td><td>1</td><td></td><td>1</td><td></td></tr></table>
331ec58ea2cdbe6921286757898d95b08b09570b1432d5ed4fc1f3b4600f3db5.png	complex	<table><tr><td>Item</td><td colspan="3">Patient Ratings</td><td colspan="3">Clinician Ratings</td></tr><tr><td></td><td>Localized</td><td>Metastatic</td><td>Total</td><td>Nurse</td><td>Physician</td><td>Total</td></tr><tr><td>PAIN</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> I have pain</td><td>2.4</td><td>1.8</td><td>2.1</td><td>3.8</td><td>4.0</td><td>3.9</td></tr><tr><td> Pain interfered with my daily activities</td><td>2.0</td><td>1.8</td><td>1.9</td><td>3.8</td><td>3.2</td><td>3.5</td></tr><tr><td> I have pain in my back</td><td>2.0</td><td>1.1</td><td>1.5</td><td>2.4</td><td>2.6</td><td>2.5</td></tr><tr><td> I have discomfort or pain in my stomach area</td><td>1.7</td><td>1.8</td><td>1.8</td><td>2.6</td><td>1.8</td><td>2.2</td></tr><tr><td>BREATHING</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> I have been short of breath</td><td>0.7</td><td>2.5</td><td>1.7</td><td>3.8</td><td>3.0</td><td>3.3</td></tr><tr><td>WEAKNESS</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> I have felt weak</td><td>2.2</td><td>2.8</td><td>2.5</td><td>4.0</td><td>3.6</td><td>3.8</td></tr><tr><td>MOOD</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> I worry that my condition will get worse</td><td>3.0</td><td>3.1</td><td>3.1</td><td>3.6</td><td>2.4</td><td>3.0</td></tr><tr><td> I have emotional ups and downs</td><td>2.6</td><td>2.2</td><td>2.4</td><td>3.6</td><td>1.6</td><td>2.6</td></tr><tr><td> I feel depressed</td><td>2.6</td><td>2.0</td><td>2.3</td><td>3.6</td><td>1.8</td><td>2.7</td></tr><tr><td> I am able to enjoy life<sup>2</sup></td><td>2.2</td><td>2.8</td><td>2.5</td><td>3.8</td><td>3.0</td><td>3.4</td></tr><tr><td>SLEEP</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> I have had trouble sleeping</td><td>2.5</td><td>2.1</td><td>2.3</td><td>3.6</td><td>2.4</td><td>3.0</td></tr><tr><td>WEIGHT LOSS</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> I am losing weight</td><td>1.4</td><td>2.0</td><td>1.7</td><td>3.5</td><td>3.6</td><td>3.6</td></tr><tr><td>COGNITIVE</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> I have difficulty remembering things</td><td>1.6</td><td>1.6</td><td>1.6</td><td>3.5</td><td>2.0</td><td>2.7</td></tr><tr><td> I have trouble concentrating</td><td>1.7</td><td>2.1</td><td>1.9</td><td>3.5</td><td>2.0</td><td>2.7</td></tr><tr><td>FATIGUE</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> I feel fatigued</td><td>2.3</td><td>2.0</td><td>2.2</td><td>3.8</td><td>3.8</td><td>3.8</td></tr><tr><td> I have a lack of energy</td><td>2.4</td><td>2.5</td><td>2.5</td><td>3.8</td><td>3.2</td><td>3.4</td></tr><tr><td> I feel tired</td><td>2.3</td><td>2.1</td><td>2.2</td><td>3.8</td><td>3.0</td><td>3.3</td></tr><tr><td> I have trouble starting things because I am tired</td><td>1.7</td><td>2.1</td><td>1.9</td><td>3.0</td><td>2.0</td><td>2.5</td></tr><tr><td> I have trouble finishing things because I am tired</td><td>1.9</td><td>2.4</td><td>2.2</td><td>3.0</td><td>2.0</td><td>2.5</td></tr><tr><td>APPETITE</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> I have lacked appetite</td><td>1.5</td><td>1.9</td><td>1.7</td><td>3.6</td><td>3.6</td><td>3.6</td></tr><tr><td> I have a good appetite<sup>3</sup></td><td>2.5</td><td>3.1</td><td>2.8</td><td>3.0</td><td>3.4</td><td>3.2</td></tr><tr><td>INCONTINENCE (BOWEL OR BLADDER)</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> I have control of my bowels<sup>4</sup></td><td>2.4</td><td>2.5</td><td>2.5</td><td>2.2</td><td>1.6</td><td>1.9</td></tr><tr><td> I have trouble moving my bowels</td><td>1.6</td><td>1.3</td><td>1.5</td><td>3.6</td><td>2.2</td><td>2.9</td></tr><tr><td> I urinate more frequently than usual<sup>5</sup></td><td>1.7</td><td>1.7</td><td>1.7</td><td>2.2</td><td>1.6</td><td>1.9</td></tr><tr><td> I have difficulty urinating</td><td>1.6</td><td>1.2</td><td>1.4</td><td>2.4</td><td>1.6</td><td>2.0</td></tr><tr><td>OTHER SYMPTOMS</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> I have had chills</td><td>1.4</td><td>1.8</td><td>1.6</td><td>3.4</td><td>2.6</td><td>3.0</td></tr><tr><td> I have had fevers</td><td>1.3</td><td>1.5</td><td>1.4</td><td>3.8</td><td>3.0</td><td>3.4</td></tr><tr><td> I have had sweats<sup>6</sup></td><td>1.2</td><td>1.1</td><td>1.1</td><td>3.8</td><td>3.2</td><td>3.5</td></tr><tr><td> I feel lightheaded</td><td>1.6</td><td>1.7</td><td>1.6</td><td>2.8</td><td>2.6</td><td>2.7</td></tr><tr><td> I am bothered by blood in my urine<sup>7</sup></td><td>n/a</td><td>n/a</td><td>n/a</td><td>2.0</td><td>2.8</td><td>2.4</td></tr></table>	<table><tr><td>Item</td><td colspan="3">Patient Ratings</td><td colspan="3">Clinician Ratings</td></tr><tr><td></td><td>Localized</td><td>Metastatic</td><td>Total</td><td>Nurse</td><td>Physician</td><td>Total</td></tr><tr><td>PAIN</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>I have pain</td><td>2.4</td><td>1.8</td><td>2.1</td><td>3.8</td><td>4.0</td><td>3.9</td></tr><tr><td>Pain interfered with my daily activities</td><td>2.0</td><td>1.8</td><td>1.9</td><td>3.8</td><td>3.2</td><td>3.5</td></tr><tr><td>I have pain in my back</td><td>2.0</td><td>1.1</td><td>1.5</td><td>2.4</td><td>2.6</td><td>2.5</td></tr><tr><td>I have discomfort or pain in my stomach area</td><td>1.7</td><td>1.8</td><td>1.8</td><td>2.6</td><td>1.8</td><td>2.2</td></tr><tr><td>BREATHING</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>I have been short of breath</td><td>0.7</td><td>2.5</td><td>1.7</td><td>3.8</td><td>3.0</td><td>3.3</td></tr><tr><td>WEAKNESS</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>I have felt weak</td><td>2.2</td><td>2.8</td><td>2.5</td><td>4.0</td><td>3.6</td><td>3.8</td></tr><tr><td>MOOD</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>I worry that my condition will get worse</td><td>3.0</td><td>3.1</td><td>3.1</td><td>3.6</td><td>2.4</td><td>3.0</td></tr><tr><td>I have emotional ups and downs</td><td>2.6</td><td>2.2</td><td>2.4</td><td>3.6</td><td>1.6</td><td>2.6</td></tr><tr><td>I feel depressed</td><td>2.6</td><td>2.0</td><td>2.3</td><td>3.6</td><td>1.8</td><td>2.7</td></tr><tr><td>I am able to enjoy life2</td><td>2.2</td><td>2.8</td><td>2.5</td><td>3.8</td><td>3.0</td><td>3.4</td></tr><tr><td>SLEEP</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>I have had trouble sleeping</td><td>2.5</td><td>2.1</td><td>2.3</td><td>3.6</td><td>2.4</td><td>3.0</td></tr><tr><td>WEIGHT LOSS</td><td></td><td></td><td></td><td></td><td></td><td></td></tr></table>	<table><tr><td>I am losing weight</td><td>1.4</td><td>2.0</td><td>1.7</td><td>3.5</td><td>3.6</td><td>3.6</td></tr><tr><td>COGNITIVE</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>I have difficulty remembering things</td><td>1.6</td><td>1.6</td><td>1.6</td><td>3.5</td><td>2.0</td><td>2.7</td></tr><tr><td>I have trouble concentrating</td><td>1.7</td><td>2.1</td><td>1.9</td><td>3.5</td><td>2.0</td><td>2.7</td></tr><tr><td>FATIGUE</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>I feel fatigued</td><td>2.3</td><td>2.0</td><td>2.2</td><td>3.8</td><td>3.8</td><td>3.8</td></tr><tr><td>I have a lack of energy</td><td>2.4</td><td>2.5</td><td>2.5</td><td>3.8</td><td>3.2</td><td>3.4</td></tr><tr><td>I feel tired</td><td>2.3</td><td>2.1</td><td>2.2</td><td>3.8</td><td>3.0</td><td>3.3</td></tr><tr><td>I have trouble starting things because I am tired</td><td>1.7</td><td>2.1</td><td>1.9</td><td>3.0</td><td>2.0</td><td>2.5</td></tr><tr><td>I have trouble finishing things because I am tired</td><td>1.9</td><td>2.4</td><td>2.2</td><td>3.0</td><td>2.0</td><td>2.5</td></tr><tr><td>APPETITE</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>I have lacked appetite</td><td>1.5</td><td>1.9</td><td>1.7</td><td>3.6</td><td>3.6</td><td>3.6</td></tr><tr><td>I have a good appetite3</td><td>2.5</td><td>3.1</td><td>2.8</td><td>3.0</td><td>3.4</td><td>3.2</td></tr><tr><td>INCONTINENCE (BOWEL OR BLADDER)</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>I have control of my bowels4</td><td>2.4</td><td>2.5</td><td>2.5</td><td>2.2</td><td>1.6</td><td>1.9</td></tr><tr><td>I have trouble moving my bowels</td><td>1.6</td><td>1.3</td><td>1.5</td><td>3.6</td><td>2.2</td><td>2.9</td></tr><tr><td>I urinate more frequently than usual5</td><td>1.7</td><td>1.7</td><td>1.7</td><td>2.2</td><td>1.6</td><td>1.9</td></tr><tr><td>I have difficulty urinating</td><td>1.6</td><td>1.2</td><td>1.4</td><td>2.4</td><td>1.6</td><td>2.0</td></tr><tr><td>OTHER SYMPTOMS</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>I have had chills</td><td>1.4</td><td>1.8</td><td>1.6</td><td>3.4</td><td>2.6</td><td>3.0</td></tr><tr><td>I have had fevers</td><td>1.3</td><td>1.5</td><td>1.4</td><td>3.8</td><td>3.0</td><td>3.4</td></tr><tr><td>I have had sweats6</td><td>1.2</td><td>1.1</td><td>1.1</td><td>3.8</td><td>3.2</td><td>3.5</td></tr><tr><td>I feel lightheaded</td><td>1.6</td><td>1.7</td><td>1.6</td><td>2.8</td><td>2.6</td><td>2.7</td></tr><tr><td>I am bothered by blood in my urine7</td><td>n/a</td><td>n/a</td><td>n/a</td><td>2.0</td><td>2.8</td><td>2.4</td></tr></table>
5e2d89443dfd3f10d94c97c629203b3367a12136f0d392c9e89f3a2b8a3e1e02.png	simple	<table><tr><td>Target genes</td><td>Primers</td></tr><tr><td>MMP1</td><td>Forward primer: 5′-aagccatcacttaccttgcact-3′</td></tr><tr><td></td><td>Reverse primer: 5′-tcagagaccttggtgaatgtca-3′</td></tr><tr><td>MMP9</td><td>Forward primer: 5′-ctggagacctgagaaccaa-3′</td></tr><tr><td></td><td>Reverse primer: 5′-actgctcaaagcctccacaaga-3′</td></tr><tr><td>β-Actin</td><td>Forward primer: 5′-ctccatcctggcctcgctgt-3′</td></tr><tr><td></td><td>Reverse primer: 5′-gctgtcaccttcaccgttcc-3′</td></tr></table>	<table><tr><td>Target genes</td><td>Primers</td></tr><tr><td>MMP1</td><td>Forward primer: 5′-aagccatcacttaccttgcact-3′</td></tr></table>	<table><tr><td>Target genes</td><td>Primers</td></tr><tr><td></td><td>Reverse primer: 5′-tcagagaccttggtgaatgtca-3′</td></tr><tr><td>MMP9</td><td>Forward primer: 5′-ctggagacctgagaaccaa-3′</td></tr><tr><td></td><td>Reverse primer: 5′-actgctcaaagcctccacaaga-3′</td></tr><tr><td>β-Actin</td><td>Forward primer: 5′-ctccatcctggcctcgctgt-3′</td></tr><tr><td></td><td>Reverse primer: 5′-gctgtcaccttcaccgttcc-3′</td></tr></table>
0648fcfbd71405fb94fb090228756acf8dfcbd4342a0319a766b44f2cb11eaf0.png	complex	<table><tr><td rowspan="2">Metal</td><td colspan="2">SQGs (mg/kg)-Freshwater Sediment (Upstream)</td><td colspan="3">Percentage of Samples Exceeding SQGs (%)</td></tr><tr><td>TEL</td><td>PEL</td><td><TEL</td><td>TEL-PEL</td><td>>PEL</td></tr><tr><td>Cu</td><td>35.7</td><td>197</td><td>80.0</td><td>16.0</td><td>4.00</td></tr><tr><td>Zn</td><td>123</td><td>315</td><td>80.0</td><td>8.00</td><td>12.0</td></tr><tr><td>Cr</td><td>37.3</td><td>90.0</td><td>32.0</td><td>44.0</td><td>24.0</td></tr><tr><td>Ni</td><td>18.0</td><td>35.9</td><td>16.0</td><td>68.0</td><td>16.0</td></tr><tr><td>Pb</td><td>35.0</td><td>91.3</td><td>96.0</td><td>4.0</td><td>0.00</td></tr><tr><td>Cd</td><td>0.60</td><td>3.53</td><td>96.0</td><td>4.00</td><td>0.00</td></tr><tr><td rowspan="2">Metal</td><td colspan="2">SQGs (mg/kg)-Marine Sediment (Downstream)</td><td colspan="3">Percentage of Samples Exceeding SQGs (%)</td></tr><tr><td>TEL</td><td>PEL</td><td><TEL</td><td>TEL-PEL</td><td>>PEL</td></tr><tr><td>Cu</td><td>18.7</td><td>108</td><td>73.3</td><td>20.0</td><td>6.67</td></tr><tr><td>Zn</td><td>124</td><td>271</td><td>93.3</td><td>0.00</td><td>6.67</td></tr><tr><td>Cr</td><td>52.3</td><td>160</td><td>73.3</td><td>26.7</td><td>0.00</td></tr><tr><td>Ni</td><td>15.9</td><td>42.8</td><td>46.7</td><td>53.3</td><td>0.00</td></tr><tr><td>Pb</td><td>30.2</td><td>112</td><td>86.7</td><td>13.3</td><td>0.00</td></tr><tr><td>Cd</td><td>0.68</td><td>4.21</td><td>93.3</td><td>6.67</td><td>0.00</td></tr></table>	<table><tr><td rowspan="2">Metal</td><td colspan="2">SQGs (mg/kg)-Freshwater Sediment (Upstream)</td><td colspan="3">Percentage of Samples Exceeding SQGs (%)</td></tr><tr><td>TEL</td><td>PEL</td><td><TEL</td><td>TEL-PEL</td><td>>PEL</td></tr></table>	<table><tr><td>Cu</td><td>35.7</td><td>197</td><td>80.0</td><td>16.0</td><td>4.00</td></tr><tr><td>Zn</td><td>123</td><td>315</td><td>80.0</td><td>8.00</td><td>12.0</td></tr><tr><td>Cr</td><td>37.3</td><td>90.0</td><td>32.0</td><td>44.0</td><td>24.0</td></tr><tr><td>Ni</td><td>18.0</td><td>35.9</td><td>16.0</td><td>68.0</td><td>16.0</td></tr><tr><td>Pb</td><td>35.0</td><td>91.3</td><td>96.0</td><td>4.0</td><td>0.00</td></tr><tr><td>Cd</td><td>0.60</td><td>3.53</td><td>96.0</td><td>4.00</td><td>0.00</td></tr><tr><td rowspan="2">Metal</td><td colspan="2">SQGs (mg/kg)-Marine Sediment (Downstream)</td><td colspan="3">Percentage of Samples Exceeding SQGs (%)</td></tr><tr><td>TEL</td><td>PEL</td><td><TEL</td><td>TEL-PEL</td><td>>PEL</td></tr><tr><td>Cu</td><td>18.7</td><td>108</td><td>73.3</td><td>20.0</td><td>6.67</td></tr><tr><td>Zn</td><td>124</td><td>271</td><td>93.3</td><td>0.00</td><td>6.67</td></tr><tr><td>Cr</td><td>52.3</td><td>160</td><td>73.3</td><td>26.7</td><td>0.00</td></tr><tr><td>Ni</td><td>15.9</td><td>42.8</td><td>46.7</td><td>53.3</td><td>0.00</td></tr><tr><td>Pb</td><td>30.2</td><td>112</td><td>86.7</td><td>13.3</td><td>0.00</td></tr><tr><td>Cd</td><td>0.68</td><td>4.21</td><td>93.3</td><td>6.67</td><td>0.00</td></tr></table>
3cf5cd8592533f8a4de912f0e011fac32465a9bbeedbb9eb5c3185796e6a935f.png	complex	<table><tr><td></td><td>Hue</td><td>Saturation</td><td>Value</td><td>Red</td><td>Green</td><td>Blue</td><td>Grey</td></tr><tr><td colspan="8">Low Resolution Normalised Images</td></tr><tr><td>Expert 1</td><td>90.8%</td><td>82.5%</td><td>85.8%</td><td>85.8%</td><td>87.0%</td><td>87.0%</td><td>90.8%</td></tr><tr><td>Expert 2</td><td>91.0%</td><td>82.8%</td><td>84.5%</td><td>84.5%</td><td>86.3%</td><td>86.3%</td><td>90.0%</td></tr><tr><td>Expert 3</td><td>91.0%</td><td>80.3%</td><td>87.5%</td><td>87.5%</td><td>89.3%</td><td>88.8%</td><td>92.5%</td></tr><tr><td>Expert 4</td><td>91.8%</td><td>84.0%</td><td>84.3%</td><td>84.3%</td><td>86.0%</td><td>86.0%</td><td>89.8%</td></tr><tr><td colspan="8">High Resolution Normalised Images</td></tr><tr><td>Expert 1</td><td>83.3%</td><td>75.0% </td><td>85.8%</td><td>87.8%</td><td>87.3%</td><td>87.5%</td><td>87.3%</td></tr><tr><td>Expert 2</td><td>84.5%</td><td>74.8% </td><td>86.0%</td><td>87.5%</td><td>87.5%</td><td>86.3%</td><td>87.5%</td></tr><tr><td>Expert 3</td><td>85.0%</td><td>75.3% </td><td>87.5%</td><td>88.5%</td><td>89.5%</td><td>87.8%</td><td>89.5%</td></tr><tr><td>Expert 4</td><td>82.3%</td><td>74.0% </td><td>83.8%</td><td>85.8%</td><td>85.3%</td><td>86.0%</td><td>85.3%</td></tr></table>	<table><tr><td></td><td>Hue</td><td>Saturation</td><td>Value</td><td>Red</td><td>Green</td><td>Blue</td><td>Grey</td></tr><tr><td colspan="8">Low Resolution Normalised Images</td></tr><tr><td>Expert 1</td><td>90.8%</td><td>82.5%</td><td>85.8%</td><td>85.8%</td><td>87.0%</td><td>87.0%</td><td>90.8%</td></tr><tr><td>Expert 2</td><td>91.0%</td><td>82.8%</td><td>84.5%</td><td>84.5%</td><td>86.3%</td><td>86.3%</td><td>90.0%</td></tr><tr><td>E</td><td>91.0%</td><td>8</td><td>8</td><td>87.</td><td>89.3%</td><td></td><td>92.5</td></tr></table>	<table><tr><td></td><td>Hue</td><td>Saturation</td><td>Value</td><td>Red</td><td>Green</td><td>Blue</td><td>Grey</td></tr><tr><td>xpert 3</td><td></td><td>0.3%</td><td>7.5%</td><td>5%</td><td></td><td>88.8%</td><td>%</td></tr><tr><td>Expert 4</td><td>91.8%</td><td>84.0%</td><td>84.3%</td><td>84.3%</td><td>86.0%</td><td>86.0%</td><td>89.8%</td></tr><tr><td colspan="8">High Resolution Normalised Images</td></tr><tr><td>Expert 1</td><td>83.3%</td><td>75.0% </td><td>85.8%</td><td>87.8%</td><td>87.3%</td><td>87.5%</td><td>87.3%</td></tr><tr><td>Expert 2</td><td>84.5%</td><td>74.8% </td><td>86.0%</td><td>87.5%</td><td>87.5%</td><td>86.3%</td><td>87.5%</td></tr><tr><td>Expert 3</td><td>85.0%</td><td>75.3% </td><td>87.5%</td><td>88.5%</td><td>89.5%</td><td>87.8%</td><td>89.5%</td></tr><tr><td>Expert 4</td><td>82.3%</td><td>74.0% </td><td>83.8%</td><td>85.8%</td><td>85.3%</td><td>86.0%</td><td>85.3%</td></tr></table>
f8b0cbeb92fcfb014be783b3f8984cde54540e9019be0cf9ca7ebbb293f384c9.png	simple	<table><tr><td>Factor</td><td>Cronbach’s α</td><td>Item-to-subscale correlation</td><td>Subscale-to-total correlation</td></tr><tr><td>1 Psychological expression</td><td>0.92</td><td>0.58–0.75</td><td>0.92</td></tr><tr><td>2 Changes in self and family</td><td>0.82</td><td>0.49–0.62</td><td>0.73</td></tr><tr><td>3 Physical symptoms</td><td>0.81</td><td>0.31–0.64</td><td>0.80</td></tr><tr><td>4 Social and family connectedness</td><td>0.73</td><td>0.30–0.73</td><td>0.39</td></tr><tr><td>5 Fatalism</td><td>0.88</td><td>0.67–0.84</td><td>0.39</td></tr><tr><td>6 Religion and faith</td><td>0.64</td><td>0.17–0.66</td><td>0.02</td></tr><tr><td>7 Self-query</td><td>0.62</td><td>0.27–0.47</td><td>0.59</td></tr><tr><td>8 Coping style</td><td>0.59</td><td>0.34–0.50</td><td>0.12</td></tr></table>	<table><tr><td>Factor</td><td>Cronbach’s α</td><td>Item-to-subscale correlation</td><td>Subscale-to-total correlation</td></tr></table>	<table><tr><td>1 Psychological expression</td><td>0.92</td><td>0.58–0.75</td><td>0.92</td></tr><tr><td>2 Changes in self and family</td><td>0.82</td><td>0.49–0.62</td><td>0.73</td></tr><tr><td>3 Physical symptoms</td><td>0.81</td><td>0.31–0.64</td><td>0.80</td></tr><tr><td>4 Social and family connectedness</td><td>0.73</td><td>0.30–0.73</td><td>0.39</td></tr><tr><td>5 Fatalism</td><td>0.88</td><td>0.67–0.84</td><td>0.39</td></tr><tr><td>6 Religion and faith</td><td>0.64</td><td>0.17–0.66</td><td>0.02</td></tr><tr><td>7 Self-query</td><td>0.62</td><td>0.27–0.47</td><td>0.59</td></tr><tr><td>8 Coping style</td><td>0.59</td><td>0.34–0.50</td><td>0.12</td></tr></table>
4e142f104ccfcfe908ba373cf59582dcba11c1b26ebdfade27cf918580132b90.png	simple	<table><tr><td></td><td>Transobturator Sling</td><td>Single-Incision Sling</td><td>p value</td></tr><tr><td>Preoperative daily pads usage (mean)</td><td>4.45±0.82 (3-6)</td><td>4.25±0.78 (3-6)</td><td>p=0.495</td></tr><tr><td>Postoperative daily pads usage (mean)</td><td>0.30±0.57 (0-2)</td><td>0.55±0,68 (0-2)</td><td>p=0.192</td></tr><tr><td>Postoperatively, the number of patients with</td><td>15 / 20</td><td>11 / 20</td><td>p=0.190</td></tr><tr><td>no pad usage (n / all patients)</td><td></td><td></td><td></td></tr><tr><td>Subjective cure rates</td><td>75%</td><td>55%</td><td>p=0.190</td></tr></table>	<table><tr><td></td><td>Transobturator Sling</td><td>Single-Incision Sling</td><td>p value</td></tr></table>	<table><tr><td>Preoperative daily pads usage (mean)</td><td>4.45±0.82 (3-6)</td><td>4.25±0.78 (3-6)</td><td>p=0.495</td></tr><tr><td>Postoperative daily pads usage (mean)</td><td>0.30±0.57 (0-2)</td><td>0.55±0,68 (0-2)</td><td>p=0.192</td></tr><tr><td>Postoperatively, the number of patients with</td><td>15 / 20</td><td>11 / 20</td><td>p=0.190</td></tr><tr><td>no pad usage (n / all patients)</td><td></td><td></td><td></td></tr><tr><td>Subjective cure rates</td><td>75%</td><td>55%</td><td>p=0.190</td></tr></table>
87273a619111f411ae5d5e41cb8b31f0fc06c8deaaad76a175281122a4c7d793.png	simple	<table><tr><td>Treatment options</td><td>Mean cost per child in A$2010-2011 (95%CI)</td><td>Mean number of QALYs (95%CI)</td><td>Mean incremental number of QALYs vs no treatment</td><td>ICER</td></tr><tr><td>No treatment</td><td>0</td><td>11.57</td><td>-</td><td>-</td></tr><tr><td></td><td></td><td>(10.24; 13.06)</td><td></td><td></td></tr><tr><td>Non-directive counselling</td><td>2125</td><td>12.59</td><td>1.02</td><td>2083</td></tr><tr><td></td><td>(1927; 2335)</td><td>(11.62; 13.57)</td><td></td><td></td></tr><tr><td>TF-CBT only</td><td>2097</td><td>12.85</td><td>1.28</td><td>1638</td></tr><tr><td></td><td>(1904; 2302)</td><td>(11.98; 13.74)</td><td></td><td></td></tr><tr><td>TF-CBT + SSRI (sertraline)</td><td>2271</td><td>12.92</td><td>1.35</td><td>1682</td></tr><tr><td></td><td>(2070; 2478)</td><td>(12.01; 13.78)</td><td></td><td></td></tr></table>	<table><tr><td>Treatment options</td><td>Mean cost per child in A$2010-2011 (95%CI)</td><td>Mean number of QALYs (95%CI)</td><td>Mean incremental number of QALYs vs no treatment</td><td>ICER</td></tr><tr><td>No treatment</td><td>0</td><td>11.57</td><td>-</td><td>-</td></tr><tr><td></td><td></td><td>(10.24; 13.06)</td><td></td><td></td></tr><tr><td>Non-directive </td><td>21</td><td>12.59</td><td></td><td>20</td></tr></table>	<table><tr><td>counselling</td><td>25</td><td></td><td>1.02</td><td>83</td></tr><tr><td></td><td>(1927; 2335)</td><td>(11.62; 13.57)</td><td></td><td></td></tr><tr><td>TF-CBT only</td><td>2097</td><td>12.85</td><td>1.28</td><td>1638</td></tr><tr><td></td><td>(1904; 2302)</td><td>(11.98; 13.74)</td><td></td><td></td></tr><tr><td>TF-CBT + SSRI (sertraline)</td><td>2271</td><td>12.92</td><td>1.35</td><td>1682</td></tr><tr><td></td><td>(2070; 2478)</td><td>(12.01; 13.78)</td><td></td><td></td></tr></table>
f4f6864fac6d96462493e472b370f217a78fae6350edad5a76a932c07b32370f.png	complex	<table><tr><td></td><td>Total dust</td><td>Respirable crystalline silica dust</td></tr><tr><td colspan="3">Long-term average exposure (mg/m<sup>3</sup>)</td></tr><tr><td>Mean (SD)</td><td>6.1 (4.8)</td><td>0.27 (0.19)</td></tr><tr><td>Median (min.–max.)</td><td>4.8 (0–36.7)</td><td>0.22 (0–1.16)</td></tr><tr><td colspan="3">Highest exposure ever* (mg/m<sup>3</sup>)</td></tr><tr><td>Mean (SD)</td><td>23.5 (11.6)</td><td>0.73 (0.34)</td></tr><tr><td>Median (min.–max.)</td><td>23.8 (0–65.8)</td><td>0.74 (0–1.95)</td></tr><tr><td colspan="3">Cumulative exposure (mg/m<sup>3</sup>-year)</td></tr><tr><td>Mean (SD)</td><td>226.4 (171.0)</td><td>7.32 (5.22)</td></tr><tr><td>Median (min.–max.)</td><td>183.7 (0–861.7)</td><td>6.20 (0–26.6)</td></tr><tr><td colspan="3">Exposure duration (years)</td></tr><tr><td>Mean (SD)</td><td colspan="2">27.8 (7.4)</td></tr><tr><td>Median (min.–max.)</td><td colspan="2">27.8 (1.1–46.4)</td></tr></table>	<table><tr><td></td><td>Total dust</td><td>Respirable crystalline silica dust</td></tr><tr><td colspan="3">Long-term average exposure (mg/m3)</td></tr><tr><td>Mean (SD)</td><td>6.1 (4.8)</td><td>0.27 (0.19)</td></tr><tr><td>Median (min.–max.)</td><td>4.8 (0–36.7)</td><td>0.22 (0–1.16)</td></tr></table>	<table><tr><td></td><td>Total dust</td><td>Respirable crystalline silica dust</td></tr><tr><td colspan="3">Highest exposure ever* (mg/m3)</td></tr><tr><td>Mean (SD)</td><td>23.5 (11.6)</td><td>0.73 (0.34)</td></tr><tr><td>Median (min.–max.)</td><td>23.8 (0–65.8)</td><td>0.74 (0–1.95)</td></tr><tr><td colspan="3">Cumulative exposure (mg/m3-year)</td></tr><tr><td>Mean (SD)</td><td>226.4 (171.0)</td><td>7.32 (5.22)</td></tr><tr><td>Median (min.–max.)</td><td>183.7 (0–861.7)</td><td>6.20 (0–26.6)</td></tr><tr><td colspan="3">Exposure duration (years)</td></tr><tr><td>Mean (SD)</td><td colspan="2">27.8 (7.4)</td></tr><tr><td>Median (min.–max.)</td><td colspan="2">27.8 (1.1–46.4)</td></tr></table>
86a7497e5e02f10f56feb2b03a8cc5ca57c480ae3ac1b3b75ff0c9924c79d6eb.png	simple	<table><tr><td> </td><td>Qigong</td><td>Exercise therapy</td><td>Study population</td></tr><tr><td> </td><td>Mean (±SD)</td><td>Mean (±SD)</td><td>Mean (±SD)</td></tr><tr><td> </td><td><i>N</i> = 10 8 female, 2 male</td><td><i>N</i> = 10 8 female, 2 male</td><td><i>N</i> = 122 107 female, 25 male</td></tr><tr><td>Age (years)</td><td>40.6 (±10.3)</td><td>44.6 (±9.3)</td><td>45.6 (±10.7)</td></tr><tr><td>VAS baseline (mm)</td><td>60.1 (±13.1)</td><td>56.5(±12.2)</td><td>56.2 (±14.1)</td></tr><tr><td>Pain duration (years)</td><td>3.9 (±1.2)</td><td>3.1 (±1.6)</td><td>3.2 (±1.6)</td></tr></table>	<table><tr><td></td><td>Qigong</td><td>Exercise therapy</td></tr><tr><td></td><td>Mean (±SD)</td><td>Mean (±SD)</td></tr><tr><td></td><td>N = 10 8 female, 2 male</td><td>N = 10 8 female, 2 male</td></tr><tr><td>Age (years)</td><td>40.6 (±10.3)</td><td>44.6 (±9.3)</td></tr><tr><td>VAS baseline (mm)</td><td>60.1 (±13.1)</td><td>56.5(±12.2)</td></tr><tr><td>Pain duration (years)</td><td>3.9 (±1.2)</td><td>3.1 (±1.6)</td></tr></table>	<table><tr><td>Study population</td></tr><tr><td>Mean (±SD)</td></tr><tr><td>N = 122 107 female, 25 male</td></tr><tr><td>45.6 (±10.7)</td></tr><tr><td>56.2 (±14.1)</td></tr><tr><td>3.2 (±1.6)</td></tr></table>