Datasets:
ChatDOC
/
OCRFlux-pubtabnet-cross

Dataset card Data Studio Files Community
1
image_name
stringlengths
68
68
type
stringclasses
2 values
gt_table
stringlengths
116
12.6k
table_fragment_1
stringlengths
43
8.42k
table_fragment_2
stringlengths
39
8.21k
098fead86afa584c45f4f9018cd4c025dfe0f1856d901d5866075062eacc8720.png
simple
<table><tr><td></td><td>Intervention Group: FFS Beneficiaries (n=317)</td><td>Control Group: Non-FFS Participants (n=254)</td><td>Difference Between Groups</td><td><i>P</i> Value</td></tr><tr><td>Household Dietary Diversity Score<sup>a</sup></td><td></td><td></td><td></td><td></td></tr><tr><td>Baseline, mean (SD)</td><td>3.4 (1.4)</td><td>3.4 (1.5)</td><td>&#8211;</td><td>&#8211;</td></tr><tr><td>Endline, mean (SD)</td><td>5.6 (2.1)</td><td>4.8 (2.1)</td><td>&#8211;</td><td>&#8211;</td></tr><tr><td>Change over time,<sup>b</sup> adjusted<sup>c</sup> mean (CI)</td><td>2.1 (1.9 to 2.4)</td><td>1.4 (1.0 to 1.7)</td><td>0.9 (0.5 to 1.3)</td><td>&lt;.001</td></tr><tr><td>Achieved target at endline,<sup>c</sup> % (CI)</td><td>69.7 (63.6 to 75.9)</td><td>48.0 (40.6 to 55.3)</td><td>21.7 (12.3 to 31.1)</td><td>&lt;.001</td></tr><tr><td>Household Food Insecurity Access Scale</td><td></td><td></td><td></td><td></td></tr><tr><td>Baseline, mean (SD)</td><td>14.4 (4.6)</td><td>14.8 (5.3)</td><td>&#8211;</td><td>&#8211;</td></tr><tr><td>Endline, mean (SD)</td><td>5.7 (5.1)</td><td>10.1 (6.1)</td><td>&#8211;</td><td>&#8211;</td></tr><tr><td>Change over time,<sup>b</sup> adjusted<sup>c</sup> mean (CI)</td><td>&#8722;8.6 (&#8722;9.4 to &#8722;7.9)</td><td>&#8722;4.7 (&#8722;5.7 to &#8722;3.7)</td><td>&#8722;4.6 (&#8722;5.0 to &#8722;4.2)</td><td>&lt;.001</td></tr><tr><td>Improved a category<sup>c</sup> (baseline to endline), % (CI)</td><td>55.3 (48.8 to 61.9)</td><td>32.4 (24.6 to 40.3)</td><td>22.9 (12.7 to 33.1)</td><td>&lt;.001</td></tr></table>
<table><tr><td></td><td>Intervention Group: FFS Beneficiaries (n=317)</td><td>Control Group: Non-FFS Participants (n=254)</td><td>Difference Between Groups</td><td>P Value</td></tr><tr><td>Household Dietary Diversity Scorea</td><td></td><td></td><td></td><td></td></tr><tr><td>Baseline, mean (SD)</td><td>3.4 (1.4)</td><td>3.4 (1.5)</td><td>–</td><td>–</td></tr><tr><td>Endline, mean (SD)</td><td>5.6 (2.1)</td><td>4.8 (2.1)</td><td>–</td><td>–</td></tr><tr><td>Change over time,b adjustedc mean (CI)</td><td>2.1 (1.9 to 2.4)</td><td>1.4 (1.0 to 1.7)</td><td>0.9 (0.5 to 1.3)</td><td><.001</td></tr></table>
<table><tr><td></td><td>Intervention Group: FFS Beneficiaries (n=317)</td><td>Control Group: Non-FFS Participants (n=254)</td><td>Difference Between Groups</td><td>P Value</td></tr><tr><td>Achieved target at endline,c % (CI)</td><td>69.7 (63.6 to 75.9)</td><td>48.0 (40.6 to 55.3)</td><td>21.7 (12.3 to 31.1)</td><td><.001</td></tr><tr><td>Household Food Insecurity Access Scale</td><td></td><td></td><td></td><td></td></tr><tr><td>Baseline, mean (SD)</td><td>14.4 (4.6)</td><td>14.8 (5.3)</td><td>–</td><td>–</td></tr><tr><td>Endline, mean (SD)</td><td>5.7 (5.1)</td><td>10.1 (6.1)</td><td>–</td><td>–</td></tr><tr><td>Change over time,b adjustedc mean (CI)</td><td>βˆ’8.6 (βˆ’9.4 to βˆ’7.9)</td><td>βˆ’4.7 (βˆ’5.7 to βˆ’3.7)</td><td>βˆ’4.6 (βˆ’5.0 to βˆ’4.2)</td><td><.001</td></tr><tr><td>Improved a categoryc (baseline to endline), % (CI)</td><td>55.3 (48.8 to 61.9)</td><td>32.4 (24.6 to 40.3)</td><td>22.9 (12.7 to 33.1)</td><td><.001</td></tr></table>
f42a13e89a7204f7d90e8a14fe17fbb9fd8313a54d2cbe3b535a397a9c3a32fa.png
complex
<table><tr><td></td><td></td><td></td><td colspan="6">Risk of malnutrition</td></tr><tr><td></td><td></td><td></td><td colspan="3">Low <i>n</i> = 159</td><td colspan="3">High <i>n</i> = 65</td></tr><tr><td></td><td></td><td></td><td>Admission</td><td>In-hospital follow up</td><td>P</td><td>Admission</td><td>In-hospital follow up</td><td>P</td></tr><tr><td>HGS, kg</td><td>&#9794;</td><td>101</td><td>26.4 (9.64)</td><td>27.5 (9.63)</td><td>0.082</td><td>24.0 (9.34)</td><td>24.8 (8.69)</td><td>0.223</td></tr><tr><td></td><td>&#9792;</td><td>120</td><td>15.2 (5.44)</td><td>15.9 (5.24)</td><td>0.069</td><td>13.0 (4.65)</td><td>14.2 (4.94)</td><td>0.115</td></tr><tr><td>SMM, kg</td><td></td><td>179</td><td>25.7 (5.36)</td><td>25.6 (5.47)</td><td>0.455</td><td>24.5 (5.75)</td><td>24.8 (5.60)</td><td>0.270</td></tr><tr><td>ALM, kg</td><td></td><td>179</td><td>19.6 (4.77)</td><td>20.0 (4.87)</td><td>0.030</td><td>18.7 (5.19)</td><td>19.5 (5.30)</td><td>0.007</td></tr><tr><td>FFM, kg</td><td></td><td>179</td><td>48.1 (9.20)</td><td>48.2 (9.43)</td><td>0.678</td><td>46.2 (10.0)</td><td>47.1 (9.96)</td><td>0.088</td></tr><tr><td>SMI, kg/m<sup>2</sup></td><td>&#9794;</td><td>78</td><td>9.90 (1.21)</td><td>9.83 (1.23)</td><td>0.404</td><td>9.00 (1.65)</td><td>9.09 (1.65)</td><td>0.470</td></tr><tr><td></td><td>&#9792;</td><td>101</td><td>8.67 (1.18)</td><td>8.62 (1.33)</td><td>0.683</td><td>8.46 (1.27)</td><td>8.58 (1.07)</td><td>0.411</td></tr><tr><td>Relative SMM, %</td><td></td><td>179</td><td>36.6 (5.59)</td><td>36.3 (5.62)</td><td>0.380</td><td>36.8 (6.73)</td><td>37.4 (7.24)</td><td>0.128</td></tr><tr><td>Relative ALM, %</td><td></td><td>179</td><td>27.6 (4.37)</td><td>28.2 (4.82)</td><td>0.027</td><td>27.9 (5.54)</td><td>29.3 (6.81)</td><td>0.002</td></tr><tr><td>Relative FFM, %</td><td></td><td>179</td><td>68.5 (10.1)</td><td>68.6 (10.3)</td><td>0.800</td><td>69.7 (12.6)</td><td>71.3 (13.8)</td><td>0.038</td></tr></table>
<table><tr><td></td><td></td><td></td><td colspan="6">Risk of malnutrition</td></tr><tr><td></td><td></td><td></td><td colspan="3">Low n = 159</td><td colspan="3">High n = 65</td></tr><tr><td></td><td></td><td></td><td>Admission</td><td>In-hospital follow up</td><td>P</td><td>Admission</td><td>In-hospital follow up</td><td>P</td></tr><tr><td>HGS, kg</td><td>β™‚</td><td>101</td><td>26.4 (9.64)</td><td>27.5 (9.63)</td><td>0.082</td><td>24.0 (9.34)</td><td>24.8 (8.69)</td><td>0.223</td></tr><tr><td></td><td>♀</td><td>120</td><td>15.2 (5.44)</td><td>15.9 (5.24)</td><td>0.069</td><td>13.0 (4.65)</td><td>14.2 (4.94)</td><td>0.115</td></tr></table>
<table><tr><td></td><td></td><td></td><td colspan="6">Risk of malnutrition</td></tr><tr><td>SMM, kg</td><td></td><td>179</td><td>25.7 (5.36)</td><td>25.6 (5.47)</td><td>0.455</td><td>24.5 (5.75)</td><td>24.8 (5.60)</td><td>0.270</td></tr><tr><td>ALM, kg</td><td></td><td>179</td><td>19.6 (4.77)</td><td>20.0 (4.87)</td><td>0.030</td><td>18.7 (5.19)</td><td>19.5 (5.30)</td><td>0.007</td></tr><tr><td>FFM, kg</td><td></td><td>179</td><td>48.1 (9.20)</td><td>48.2 (9.43)</td><td>0.678</td><td>46.2 (10.0)</td><td>47.1 (9.96)</td><td>0.088</td></tr><tr><td>SMI, kg/m2</td><td>β™‚</td><td>78</td><td>9.90 (1.21)</td><td>9.83 (1.23)</td><td>0.404</td><td>9.00 (1.65)</td><td>9.09 (1.65)</td><td>0.470</td></tr><tr><td></td><td>♀</td><td>101</td><td>8.67 (1.18)</td><td>8.62 (1.33)</td><td>0.683</td><td>8.46 (1.27)</td><td>8.58 (1.07)</td><td>0.411</td></tr><tr><td>Relative SMM, %</td><td></td><td>179</td><td>36.6 (5.59)</td><td>36.3 (5.62)</td><td>0.380</td><td>36.8 (6.73)</td><td>37.4 (7.24)</td><td>0.128</td></tr><tr><td>Relative ALM, %</td><td></td><td>179</td><td>27.6 (4.37)</td><td>28.2 (4.82)</td><td>0.027</td><td>27.9 (5.54)</td><td>29.3 (6.81)</td><td>0.002</td></tr><tr><td>Relative FFM, %</td><td></td><td>179</td><td>68.5 (10.1)</td><td>68.6 (10.3)</td><td>0.800</td><td>69.7 (12.6)</td><td>71.3 (13.8)</td><td>0.038</td></tr></table>
50729b7881163654368954f8d66a99e2333ae5893fa86f877d73c91a8f6dfab1.png
complex
<table><tr><td> </td><td colspan="2">All (n = 198)</td><td colspan="2">Boys (n = 101)</td><td colspan="2">Girls (n = 97)</td></tr><tr><td>Symptoms presence</td><td>No (n = 148)</td><td>Yes (n = 50)</td><td>No (n = 82)</td><td>Yes (n = 19)</td><td>No (n = 66)</td><td>Yes (n = 31)</td></tr><tr><td>IgE (mg/dL)</td><td>127 &#177; 273</td><td>258 &#177; 483*</td><td>168 &#177; 319</td><td>321 &#177; 595*</td><td>75 &#177; 190</td><td>220 &#177; 405&#176;</td></tr><tr><td>Leptin (pg/mL)</td><td>7043 &#177; 6196</td><td>10280 &#177; 8184*</td><td>4595 &#177; 4902</td><td>4602 &#177; 5682</td><td>10084 &#177; 6317</td><td>13761 &#177; 7555*</td></tr><tr><td>Eosinophils (%)</td><td>2.9 &#177; 2.8</td><td>3.0 &#177; 1.7</td><td>3.6 &#177; 3.6</td><td>4.1 &#177; 1.9</td><td>2.2 &#177; 1.0</td><td>2.4 &#177; 1.2</td></tr><tr><td>Interleukin-2 (pg/mL)</td><td>12.7 &#177; 22.3</td><td>15.7 &#177; 28.4</td><td>9.5 &#177; 13.1</td><td>18.5 &#177; 42.7</td><td>16.7 &#177; 29.6</td><td>14.1 &#177; 14.7</td></tr><tr><td>Interleukin-4 (pg/mL)</td><td>185 &#177; 280</td><td>170 &#177; 237</td><td>204 &#177; 305</td><td>208 &#177; 254</td><td>159 &#177; 243</td><td>141 &#177; 225</td></tr><tr><td>Interleukin -5 (pg/mL)</td><td>3.2 &#177; 21.8</td><td>1.6 &#177; 1.5</td><td>1.2 &#177; 1.5</td><td>1.4 &#177; 1.2</td><td>5.5 &#177; 32.5</td><td>1.6 &#177; 1.8</td></tr><tr><td>Interleukin &#8722;10 (pg/mL)</td><td>65 &#177; 181</td><td>50 &#177; 89</td><td>32 &#177; 33</td><td>46 &#177; 61</td><td>108 &#177; 264</td><td>52 &#177; 103</td></tr></table>
<table><tr><td></td><td colspan="2">All (n = 198)</td><td colspan="2">Boys (n = 101)</td><td colspan="2">Girls (n = 97)</td></tr><tr><td>Symptoms presence</td><td>No (n = 148)</td><td>Yes (n = 50)</td><td>No (n = 82)</td><td>Yes (n = 19)</td><td>No (n = 66)</td><td>Yes (n = 31)</td></tr><tr><td>IgE (mg/dL)</td><td>127 Β± 273</td><td>258 Β± 483*</td><td>168 Β± 319</td><td>321 Β± 595*</td><td>75 Β± 190</td><td>220 Β± 405Β°</td></tr><tr><td>Leptin (pg/mL)</td><td>7043 Β± 6196</td><td>10280 Β± 8184*</td><td>4595 Β± 4902</td><td>4602 Β± 5682</td><td>10084 Β± 6317</td><td>13761 Β± 7555*</td></tr><tr><td>Eosinophils (%)</td><td>2.9 Β± 2.8</td><td>3.0 Β± 1.7</td><td>3.6 Β± 3.6</td><td>4.1 Β± 1.9</td><td>2.2 Β± 1.0</td><td>2.4 Β± 1.2</td></tr><tr><td>Interleukin-2 (pg/mL)</td><td>12.7 Β± 22.3</td><td>15.7 Β± 28.4</td><td>9.5 Β± 13.1</td><td>18.5 Β± 42.7</td><td>16.7 Β± 29.6</td><td>14.1 Β± 14.7</td></tr><tr><td>Interleukin-4 (pg/mL)</td><td>185 Β± 280</td><td>170 Β± 237</td><td>204 Β± 305</td><td>208 Β± 254</td><td>159 Β± 243</td><td>141 Β± 225</td></tr><tr><td>Interleukin -5 (pg/mL)</td><td>3.2 Β± 21.8</td><td>1.6 Β± 1.5</td><td>1.2 Β± 1.5</td><td>1.4 Β± 1.2</td><td>5.5 Β± 32.5</td><td>1.6 Β± 1.8</td></tr></table>
<table><tr><td></td><td colspan="2">All (n = 198)</td><td colspan="2">Boys (n = 101)</td><td colspan="2">Girls (n = 97)</td></tr><tr><td>Symptoms presence</td><td>No (n = 148)</td><td>Yes (n = 50)</td><td>No (n = 82)</td><td>Yes (n = 19)</td><td>No (n = 66)</td><td>Yes (n = 31)</td></tr><tr><td>Interleukin βˆ’10 (pg/mL)</td><td>65 Β± 181</td><td>50 Β± 89</td><td>32 Β± 33</td><td>46 Β± 61</td><td>108 Β± 264</td><td>52 Β± 103</td></tr></table>
2defc968fb40fa75239ed6840237d1ec99fd7b7ce0347238fe596381da96db79.png
complex
<table><tr><td></td><td colspan="6">Weighted percentage (95% CI)<sup>2</sup></td></tr><tr><td></td><td>1993</td><td>1995</td><td>1997</td><td>1999</td><td>2001</td><td>2003</td></tr><tr><td>All</td><td>15.7 (14.6 to 16.8)</td><td>16.0 (13.8 to 18.5)</td><td>17.6 (15.9 to 19.4)</td><td>16.0 (14.5 to 17.7)</td><td>15.8 (14.7 to 16.9)</td><td>18.3 (16.2 to 20.7)</td></tr><tr><td colspan="7">Gender</td></tr><tr><td> Girls</td><td>20.8 (19.1 to 22.6)</td><td>22.0 (18.2 to 26.4)</td><td>24.2 (21.2 to 27.6)</td><td>20.8 (18.3 to 23.4)</td><td>20.0 (18.2 to 21.9)</td><td>22.2 (19.3 to 25.3)</td></tr><tr><td> Boys</td><td>10.9 (9.8 to 12.0)</td><td>10.5 (9.2 to 11.8)</td><td>12.1 (11.1 to 13.2)</td><td>11.4 (9.4 to 13.7)</td><td>11.3 (10.3 to 12.4)</td><td>14.7 (12.7 to 16.8)</td></tr><tr><td colspan="7">School Grade</td></tr><tr><td> 9</td><td>9.5 (8.3 to 10.8)</td><td>12.3 (9.8 to 15.3)</td><td>13.3 (11.5 to 15.3)</td><td>12.0 (9.6 to 15.0)</td><td>11.2 (9.9 to 12.6)</td><td>14.6 (12.2 to 17.4)</td></tr><tr><td> 10</td><td>13.4 (11.8 to 15.3)</td><td>12.1 (9.8 to 14.8)</td><td>16.7 (14.7 to 18.9)</td><td>15.2 (12.1 to 18.9)</td><td>14.1 (12.5 to 15.8)</td><td>17.0 (14.8 to 19.4)</td></tr><tr><td> 11</td><td>17.2 (15.5 to 19.0)</td><td>18.7 (14.5 to 23.8)</td><td>17.9 (15.3 to 20.8)</td><td>19.3 (16.5 to 22.4)</td><td>18.9 (17.3 to 20.7)</td><td>20.2 (17.3 to 23.3)</td></tr><tr><td> 12</td><td>21.6 (19.2 to 24.2)</td><td>20.4 (16.9 to 24.4)</td><td>21.8 (17.8 to 26.3)</td><td>19.0 (15.2 to 22.2)</td><td>20.6 (18.2 to 23.3)</td><td>22.9 (19.6 to 26.7)</td></tr><tr><td colspan="7">Race</td></tr><tr><td> NHW<sup>3</sup></td><td>14.2 (13.0 to 15.6)</td><td>13.3 (11.3 to 15.7)</td><td>15.2 (13.0 to 17.7)</td><td>14.3 (13.0 to 15.8)</td><td>14.4 (13.1 to 15.9)</td><td>16.7 (13.9 to 20.0)</td></tr><tr><td> Black<sup>4</sup></td><td>22.3 (20.2 to 24.6)</td><td>25.1 (22.0 to 28.4)</td><td>26.0 (22.7 to 29.6)</td><td>24.5 (19.3 to 30.5)</td><td>19.8 (17.5 to 22.3)</td><td>23.8 (21.2 to 26.6)</td></tr><tr><td> HW<sup>5</sup></td><td>17.1 (15.2 to 19.1)</td><td>20.5 (16.6 to 25.0)</td><td>17.3 (14.5 to 20.6)</td><td>17.8 (14.7 to 21.4)</td><td>18.1 (16.4 to 19.9)</td><td>20.1 (17.8 to 22.6)</td></tr><tr><td> Other</td><td>15.2 (12.5 to 18.4)</td><td>16.5 (11.0 to 23.9)</td><td>20.8 (16.6 to 25.7)</td><td>14.9 (11.5 to 19.0)</td><td>17.8 (15.4 to 20.4)</td><td>18.5 (15.6 to 21.8)</td></tr></table>
<table><tr><td></td><td colspan="2">Weighted percentage (95% CI)2</td></tr><tr><td></td><td>1993</td><td>1995</td></tr><tr><td>All</td><td>15.7 (14.6 to 16.8)</td><td>16.0 (13.8 to 18.5)</td></tr><tr><td colspan="3">Gender</td></tr><tr><td>Girls</td><td>20.8 (19.1 to 22.6)</td><td>22.0 (18.2 to 26.4)</td></tr><tr><td>Boys</td><td>10.9 (9.8 to 12.0)</td><td>10.5 (9.2 to 11.8)</td></tr><tr><td colspan="3">School Grade</td></tr><tr><td>9</td><td>9.5 (8.3 to 10.8)</td><td>12.3 (9.8 to 15.3)</td></tr><tr><td>10</td><td>13.4 (11.8 to 15.3)</td><td>12.1 (9.8 to 14.8)</td></tr><tr><td>11</td><td>17.2 (15.5 to 19.0)</td><td>18.7 (14.5 to 23.8)</td></tr><tr><td>12</td><td>21.6 (19.2 to 24.2)</td><td>20.4 (16.9 to 24.4)</td></tr><tr><td colspan="3">Race</td></tr><tr><td>NHW3</td><td>14.2 (13.0 to 15.6)</td><td>13.3 (11.3 to 15.7)</td></tr><tr><td>Black4</td><td>22.3 (20.2 to 24.6)</td><td>25.1 (22.0 to 28.4)</td></tr><tr><td>HW5</td><td>17.1 (15.2 to 19.1)</td><td>20.5 (16.6 to 25.0)</td></tr><tr><td>Other</td><td>15.2 (12.5 to 18.4)</td><td>16.5 (11.0 to 23.9)</td></tr></table>
<table><tr><td colspan="4">Weighted percentage (95% CI)2</td></tr><tr><td>1997</td><td>1999</td><td>2001</td><td>2003</td></tr><tr><td>17.6 (15.9 to 19.4)</td><td>16.0 (14.5 to 17.7)</td><td>15.8 (14.7 to 16.9)</td><td>18.3 (16.2 to 20.7)</td></tr><tr><td colspan="4">Gender</td></tr><tr><td>24.2 (21.2 to 27.6)</td><td>20.8 (18.3 to 23.4)</td><td>20.0 (18.2 to 21.9)</td><td>22.2 (19.3 to 25.3)</td></tr><tr><td>12.1 (11.1 to 13.2)</td><td>11.4 (9.4 to 13.7)</td><td>11.3 (10.3 to 12.4)</td><td>14.7 (12.7 to 16.8)</td></tr><tr><td colspan="4">School Grade</td></tr><tr><td>13.3 (11.5 to 15.3)</td><td>12.0 (9.6 to 15.0)</td><td>11.2 (9.9 to 12.6)</td><td>14.6 (12.2 to 17.4)</td></tr><tr><td>16.7 (14.7 to 18.9)</td><td>15.2 (12.1 to 18.9)</td><td>14.1 (12.5 to 15.8)</td><td>17.0 (14.8 to 19.4)</td></tr><tr><td>17.9 (15.3 to 20.8)</td><td>19.3 (16.5 to 22.4)</td><td>18.9 (17.3 to 20.7)</td><td>20.2 (17.3 to 23.3)</td></tr><tr><td>21.8 (17.8 to 26.3)</td><td>19.0 (15.2 to 22.2)</td><td>20.6 (18.2 to 23.3)</td><td>22.9 (19.6 to 26.7)</td></tr><tr><td colspan="4">Race</td></tr><tr><td>15.2 (13.0 to 17.7)</td><td>14.3 (13.0 to 15.8)</td><td>14.4 (13.1 to 15.9)</td><td>16.7 (13.9 to 20.0)</td></tr><tr><td>26.0 (22.7 to 29.6)</td><td>24.5 (19.3 to 30.5)</td><td>19.8 (17.5 to 22.3)</td><td>23.8 (21.2 to 26.6)</td></tr><tr><td>17.3 (14.5 to 20.6)</td><td>17.8 (14.7 to 21.4)</td><td>18.1 (16.4 to 19.9)</td><td>20.1 (17.8 to 22.6)</td></tr><tr><td>20.8 (16.6 to 25.7)</td><td>14.9 (11.5 to 19.0)</td><td>17.8 (15.4 to 20.4)</td><td>18.5 (15.6 to 21.8)</td></tr></table>
a5d09237aec64fb54d7949ec9b35ce990de93a26f7acf7fe89d41e1a4f6014a0.png
simple
<table><tr><td> </td><td>Group 1</td><td>Group 2</td><td>Group 3</td><td><i>p</i> value</td></tr><tr><td>M<sub>2</sub> oocyte counts</td><td>1.7 &#177; 0.9</td><td>1.7 &#177; 0.8</td><td>1.9 &#177; 1.0</td><td>0.461 </td></tr><tr><td>Fertilization rates (%)</td><td>82.3 &#177; 32.2</td><td>79.6 &#177; 33.4</td><td>64.4 &#177; 34.4<sup>a,b</sup></td><td>0.04</td></tr><tr><td>Embryo counts</td><td>1.5 &#177; 1.0</td><td>1.3 &#177; 0.8</td><td>1.5 &#177; 1.0</td><td>0.685 </td></tr><tr><td>Stimulation duration (days)</td><td>8.5 &#177; 2.5</td><td>8.6 &#177; 2.0</td><td>8.6 &#177; 3.1</td><td>0.977</td></tr><tr><td>Gonadotropin dose (units)</td><td>2993 &#177; 1212</td><td>2772 &#177; 844</td><td>2752.8 &#177; 1003</td><td>0.546</td></tr><tr><td>Clinical pregnancy rates (%)</td><td>33.3</td><td>25</td><td>15<sup>c</sup></td><td>0.02</td></tr><tr><td>Cycle cancellation rates (%)</td><td>16.6</td><td>17.3</td><td>20</td><td>0.732</td></tr></table>
<table><tr><td></td><td>Group 1</td><td>Group 2</td><td>Group 3</td><td>p value</td></tr><tr><td>M2 oocyte counts</td><td>1.7 Β± 0.9</td><td>1.7 Β± 0.8</td><td>1.9 Β± 1.0</td><td>0.461</td></tr><tr><td>Fertilization rates (%)</td><td>82.3 Β± 32.2</td><td>79.6 Β± 33.4</td><td>64.4 Β± 34.4a,b</td><td>0.04</td></tr><tr><td>Embryo counts</td><td>1.5 Β± 1.0</td><td>1.3 Β± 0.8</td><td>1.5 Β± 1.0</td><td>0.685</td></tr><tr><td>Stimulation duration (days)</td><td>8.5 Β± 2.5</td><td>8.6 Β± 2.0</td><td>8.6 Β± 3.1</td><td>0.977</td></tr><tr><td>Gonadotropin dose (units)</td><td>2993 Β± 1212</td><td>2772 Β± 844</td><td>2752.8 Β± 1003</td><td>0.546</td></tr></table>
<table><tr><td></td><td>Group 1</td><td>Group 2</td><td>Group 3</td><td>p value</td></tr><tr><td>Clinical pregnancy rates (%)</td><td>33.3</td><td>25</td><td>15c</td><td>0.02</td></tr><tr><td>Cycle cancellation rates (%)</td><td>16.6</td><td>17.3</td><td>20</td><td>0.732</td></tr></table>
fa2f45dd708eb27a141f66cda17651d4af989d09c515f19734e7ea40ae5209b4.png
complex
<table><tr><td colspan="8">Dose Intensity Rates (DSI) in percentage</td></tr><tr><td colspan="3">GEM Group (<i>n</i> = 9)</td><td colspan="5">CIS/GEM Group (<i>n</i> = 21)</td></tr><tr><td colspan="3"></td><td></td><td colspan="2">CIS</td><td colspan="2">GEM</td></tr><tr><td>Cycles</td><td>Median</td><td>IQR</td><td>Cycles</td><td>Median</td><td>IQR</td><td>Median</td><td>IQR</td></tr><tr><td>C1</td><td>100</td><td>(91.7&#8211;100)</td><td>C1</td><td>100</td><td>(100&#8211;100)</td><td>100</td><td>(100&#8211;100)</td></tr><tr><td>C2</td><td>100</td><td>(95&#8211;100)</td><td>C2</td><td>100</td><td>(100&#8211;100)</td><td>100</td><td>(100&#8211;100)</td></tr><tr><td>C3</td><td>100</td><td>(90.9&#8211;100)</td><td>C3</td><td>100</td><td>(70&#8211;100)</td><td>100</td><td>(76.4&#8211;100)</td></tr><tr><td>C4</td><td>100</td><td>(86.7&#8211;100)</td><td>C4</td><td>80</td><td>(50&#8211;100)</td><td>100</td><td>(77.5&#8211;100)</td></tr><tr><td>C5</td><td>100</td><td>(95&#8211;100)</td><td>C5</td><td>80</td><td>(50&#8211;100)</td><td>100</td><td>(70&#8211;100)</td></tr><tr><td>C6</td><td>100</td><td>(88.9&#8211;100)</td><td>C6</td><td>80</td><td>(25&#8211;100)</td><td>94.1</td><td>(70&#8211;100)</td></tr><tr><td></td><td></td><td></td><td>C7</td><td>50</td><td>(0&#8211;100)</td><td>88.9</td><td>(56.3&#8211;100)</td></tr><tr><td></td><td></td><td></td><td>C8</td><td>50</td><td>(0&#8211;90)</td><td>75</td><td>(50&#8211;100)</td></tr><tr><td>Overall DSI</td><td>100</td><td>(91&#8211;100)</td><td></td><td>100</td><td>(50&#8211;100)</td><td>100</td><td>(75&#8211;100)</td></tr></table>
<table><tr><td colspan="8">Dose Intensity Rates (DSI) in percentage</td></tr><tr><td colspan="3">GEM Group (n = 9)</td><td colspan="5">CIS/GEM Group (n = 21)</td></tr><tr><td colspan="3"></td><td></td><td colspan="2">CIS</td><td colspan="2">GEM</td></tr><tr><td>Cycles</td><td>Median</td><td>IQR</td><td>Cycles</td><td>Median</td><td>IQR</td><td>Median</td><td>IQR</td></tr><tr><td>C1</td><td>100</td><td>(91.7–100)</td><td>C1</td><td>100</td><td>(100–100)</td><td>100</td><td>(100–100)</td></tr><tr><td>C2</td><td>100</td><td>(95–100)</td><td>C2</td><td>100</td><td>(100–100)</td><td>100</td><td>(100–100)</td></tr></table>
<table><tr><td colspan="8">Dose Intensity Rates (DSI) in percentage</td></tr><tr><td colspan="3">GEM Group (n = 9)</td><td colspan="5">CIS/GEM Group (n = 21)</td></tr><tr><td colspan="3"></td><td></td><td colspan="2">CIS</td><td colspan="2">GEM</td></tr><tr><td>Cycles</td><td>Median</td><td>IQR</td><td>Cycles</td><td>Median</td><td>IQR</td><td>Median</td><td>IQR</td></tr><tr><td>C3</td><td>100</td><td>(90.9–100)</td><td>C3</td><td>100</td><td>(70–100)</td><td>100</td><td>(76.4–100)</td></tr><tr><td>C4</td><td>100</td><td>(86.7–100)</td><td>C4</td><td>80</td><td>(50–100)</td><td>100</td><td>(77.5–100)</td></tr><tr><td>C5</td><td>100</td><td>(95–100)</td><td>C5</td><td>80</td><td>(50–100)</td><td>100</td><td>(70–100)</td></tr><tr><td>C6</td><td>100</td><td>(88.9–100)</td><td>C6</td><td>80</td><td>(25–100)</td><td>94.1</td><td>(70–100)</td></tr><tr><td></td><td></td><td></td><td>C7</td><td>50</td><td>(0–100)</td><td>88.9</td><td>(56.3–100)</td></tr><tr><td></td><td></td><td></td><td>C8</td><td>50</td><td>(0–90)</td><td>75</td><td>(50–100)</td></tr><tr><td>Overall DSI</td><td>100</td><td>(91–100)</td><td></td><td>100</td><td>(50–100)</td><td>100</td><td>(75–100)</td></tr></table>
c651a3aab586906f4a6fec046062f4fe15e4eee59c9014bf3a62d2cc09c2222e.png
complex
<table><tr><td>Trait</td><td>Rationale</td><td>Categories</td><td>Codes</td></tr><tr><td rowspan="7">Potential size (mm)</td><td rowspan="7">The predator may prefer a particular size range because prey size is a trade&#8208;off among costs and benefits of foraging</td><td>&#8804;2.5</td><td>&lt;2.5</td></tr><tr><td>2.5&#8211;5</td><td>2.5&#8211;5</td></tr><tr><td>5&#8211;10</td><td>5&#8211;10</td></tr><tr><td>10&#8211;20</td><td>10&#8211;20</td></tr><tr><td>20&#8211;40</td><td>20&#8211;40</td></tr><tr><td>40&#8211;80</td><td>40&#8211;80</td></tr><tr><td>&gt;80</td><td>&gt;80</td></tr><tr><td rowspan="4">Body shape (including cases/tubes)</td><td rowspan="4">Body shape can affect handling efficiency</td><td>Cylindrical</td><td>cyl</td></tr><tr><td>Spherical</td><td>sph</td></tr><tr><td>Conical</td><td>con</td></tr><tr><td>Flattened</td><td>flat</td></tr><tr><td rowspan="3">Body flexibility (including cases/tubes)</td><td rowspan="3">Higher body flexibility may be preferred because it compromises lower handling time</td><td>None</td><td>f.no</td></tr><tr><td>Weak</td><td>f.weak</td></tr><tr><td>High</td><td>f.high</td></tr><tr><td rowspan="5">Concealment</td><td rowspan="5">Prey concealment (colored patterns, accessories) may reduce vulnerability to predation</td><td>Fixed accessory (nets, retreats)</td><td>net</td></tr><tr><td>Movable accessory (cases, tubes)</td><td>case</td></tr><tr><td>Solidly colored</td><td>c.sol</td></tr><tr><td>Variable</td><td>c.var</td></tr><tr><td>Patterned</td><td>c.patt</td></tr><tr><td rowspan="2">Morphological defenses</td><td rowspan="2">Morphological defenses may reduce vulnerability to predation</td><td>Cerci, silk, spine</td><td>def.sp</td></tr><tr><td>None</td><td>def.no</td></tr><tr><td rowspan="6">Locomotion and substrate relation</td><td rowspan="6">Crawlers, burrowers and attached organisms may be more vulnerable to predation because the fish foraging preferences (benthic)</td><td>Surface swimmer</td><td>surf.s</td></tr><tr><td>Full water swimmer</td><td>wat.s</td></tr><tr><td>Crawler</td><td>craw</td></tr><tr><td>Burrower</td><td>burw</td></tr><tr><td>Interstitial</td><td>int</td></tr><tr><td>Attached</td><td>att</td></tr><tr><td rowspan="4">Tendency to drift in the water column</td><td rowspan="4">Drift tendency may increase vulnerability to predation</td><td>None</td><td>d.no</td></tr><tr><td>Weak</td><td>d.weak</td></tr><tr><td>Medium</td><td>d.med</td></tr><tr><td>High</td><td>d.high</td></tr><tr><td rowspan="5">Diel drift behavior</td><td rowspan="5">Nocturnal drift may reduce vulnerability to predation because foraging efficiency can decrease with a decrease in luminosity</td><td>None</td><td>none</td></tr><tr><td>Nocturnal</td><td>noct</td></tr><tr><td>Dawn</td><td>dawn</td></tr><tr><td>Daylight</td><td>d.light</td></tr><tr><td>Twilight</td><td>t.light</td></tr><tr><td rowspan="3">Agility</td><td rowspan="3">High agility may increase encounter rate with the predator, increasing prey vulnerability to predation</td><td>None (sluggish)</td><td>a.no</td></tr><tr><td>Weak</td><td>a.weak</td></tr><tr><td>High</td><td>a.high</td></tr><tr><td rowspan="2">Movement frequency</td><td rowspan="2">Continuous movement may increase vulnerability to predation because it may reduce hunting time</td><td>Continuous</td><td>cont</td></tr><tr><td>Discontinuous</td><td>disc</td></tr><tr><td rowspan="4">Trajectory on the bottom substratum or in the drift</td><td rowspan="4">Random trajectory may reduce vulnerability to predation because it may increase hunting time</td><td>None</td><td>t.no</td></tr><tr><td>Linear</td><td>t.lin</td></tr><tr><td>By random</td><td>t.rand</td></tr><tr><td>Oscillatory</td><td>t.oscil</td></tr><tr><td rowspan="2">Aggregation tendency</td><td rowspan="2">Aggregation may increase vulnerability trough increasing conspicuous to predators, but may be also an antipredator strategy</td><td>Weak</td><td>ag.weak</td></tr><tr><td>High</td><td>ag.high</td></tr><tr><td rowspan="8">Feeding habits</td><td rowspan="8">Habitat use by the predatory fish may affect differently to the potential prey depending on prey feeding habits</td><td>Absorber</td><td>abs</td></tr><tr><td>Deposit feeder</td><td>dpfd</td></tr><tr><td>Shredder</td><td>shrd</td></tr><tr><td>Scraper</td><td>scrp</td></tr><tr><td>Filter&#8208;feeder</td><td>filt</td></tr><tr><td>Piercer</td><td>pier</td></tr><tr><td>Predator</td><td>pred</td></tr><tr><td>Parasite</td><td>par</td></tr></table>
<table><tr><td>Trait</td><td>Rationale</td><td>Categories</td><td>Codes</td></tr><tr><td rowspan="7">Potential size (mm)</td><td rowspan="7">The predator may prefer a particular size range because prey size is a trade‐off among costs and benefits of foraging</td><td>≀2.5</td><td><2.5</td></tr><tr><td>2.5–5</td><td>2.5–5</td></tr><tr><td>5–10</td><td>5–10</td></tr><tr><td>10–20</td><td>10–20</td></tr><tr><td>20–40</td><td>20–40</td></tr><tr><td>40–80</td><td>40–80</td></tr><tr><td>>80</td><td>>80</td></tr><tr><td rowspan="4">Body shape (including cases/tubes)</td><td rowspan="4">Body shape can affect handling efficiency</td><td>Cylindrical</td><td>cyl</td></tr><tr><td>Spherical</td><td>sph</td></tr><tr><td>Conical</td><td>con</td></tr><tr><td>Flattened</td><td>flat</td></tr><tr><td rowspan="3">Body flexibility (including cases/tubes)</td><td rowspan="3">Higher body flexibility may be preferred because it compromises lower handling time</td><td>None</td><td>f.no</td></tr><tr><td>Weak</td><td>f.weak</td></tr><tr><td>High</td><td>f.high</td></tr><tr><td rowspan="5">Concealment</td><td rowspan="5">Prey concealment (colored patterns, accessories) may reduce vulnerability to predation</td><td>Fixed accessory (nets, retreats)</td><td>net</td></tr><tr><td>Movable accessory (cases, tubes)</td><td>case</td></tr><tr><td>Solidly colored</td><td>c.sol</td></tr><tr><td>Variable</td><td>c.var</td></tr><tr><td>Patterned</td><td>c.patt</td></tr><tr><td rowspan="2">Morphological defenses</td><td rowspan="2">Morphological defenses may reduce vulnerability to predation</td><td>Cerci, silk, spine</td><td>def.sp</td></tr><tr><td>None</td><td>def.no</td></tr><tr><td rowspan="6">Locomotion and substrate relation</td><td rowspan="6">Crawlers, burrowers and attached organisms may be more vulnerable to predation because the fish foraging preferences (benthic)</td><td>Surface swimmer</td><td>surf.s</td></tr><tr><td>Full water swimmer</td><td>wat.s</td></tr><tr><td>Crawler</td><td>craw</td></tr><tr><td>Burrower</td><td>burw</td></tr><tr><td>Interstitial</td><td>int</td></tr><tr><td>Attached</td><td>att</td></tr><tr><td rowspan="4">Tendency to drift in the water column</td><td rowspan="4">Drift tendency may increase vulnerability to predation</td><td>None</td><td>d.no</td></tr><tr><td>Weak</td><td>d.weak</td></tr><tr><td>Medium</td><td>d.med</td></tr><tr><td>High</td><td>d.high</td></tr><tr><td rowspan="5">Diel drift behavior</td><td rowspan="5">Nocturnal drift may reduce vulnerability to predation because foraging efficiency can decrease with a decrease in luminosity</td><td>None</td><td>none</td></tr><tr><td>Nocturnal</td><td>noct</td></tr><tr><td>Dawn</td><td>dawn</td></tr><tr><td>Daylight</td><td>d.light</td></tr><tr><td>Twilight</td><td>t.light</td></tr><tr><td rowspan="2">Agility</td><td rowspan="2">High agility may increase encounter rate with the predator, increasing prey vulnerability to predation</td><td>None (sluggish)</td><td>a.no</td></tr><tr><td>Weak</td><td>a.weak</td></tr></table>
<table><tr><td>Agility</td><td>High agility may increase encounter rate with the predator, increasing prey vulnerability to predation</td><td>High</td><td>a.high</td></tr><tr><td rowspan="2">Movement frequency</td><td rowspan="2">Continuous movement may increase vulnerability to predation because it may reduce hunting time</td><td>Continuous</td><td>cont</td></tr><tr><td>Discontinuous</td><td>disc</td></tr><tr><td rowspan="4">Trajectory on the bottom substratum or in the drift</td><td rowspan="4">Random trajectory may reduce vulnerability to predation because it may increase hunting time</td><td>None</td><td>t.no</td></tr><tr><td>Linear</td><td>t.lin</td></tr><tr><td>By random</td><td>t.rand</td></tr><tr><td>Oscillatory</td><td>t.oscil</td></tr><tr><td rowspan="2">Aggregation tendency</td><td rowspan="2">Aggregation may increase vulnerability trough increasing conspicuous to predators, but may be also an antipredator strategy</td><td>Weak</td><td>ag.weak</td></tr><tr><td>High</td><td>ag.high</td></tr><tr><td rowspan="8">Feeding habits</td><td rowspan="8">Habitat use by the predatory fish may affect differently to the potential prey depending on prey feeding habits</td><td>Absorber</td><td>abs</td></tr><tr><td>Deposit feeder</td><td>dpfd</td></tr><tr><td>Shredder</td><td>shrd</td></tr><tr><td>Scraper</td><td>scrp</td></tr><tr><td>Filter‐feeder</td><td>filt</td></tr><tr><td>Piercer</td><td>pier</td></tr><tr><td>Predator</td><td>pred</td></tr><tr><td>Parasite</td><td>par</td></tr></table>
2c341b83d76e2e408679113d71962597fd8187c2e0ffd9aec2b59e22b8c5e71e.png
simple
<table><tr><td>Author</td><td>Study design</td><td>Aim of the study</td><td>Sample size</td><td>Conclusion</td></tr><tr><td>Dunn M, et al<sup>32</sup>Michigan,USA 2007</td><td>. Case control</td><td>Assessment of OPG in regulatingmechanically induced bone modeling in a rat model of orthodontic toothmovement.</td><td>39 male Sprague-Dawley rats &#187; 9rats without appliances: (3 rats without injections, 3 rats with vehicleand 3 rats with high-dose OPG) &#187; 30 rats with orthodontic forces: (10rats with 0.5 mg/Kg OPG-Fc, 10 rats with 5.0 mg/Kg OPG-Fc and 10 ratswith vehicle)</td><td>Local delivery of OPG-Fc inhibitsosteoclastogenesis and tooth movement at targeted dental sites.</td></tr><tr><td>Keles A, et al<sup>31</sup>BostonUSA 2007</td><td>Case control</td><td>Evaluation of the efficacy ofpamidronate<i>versus</i> osteoprotegerin (OPG) in theinhibition of bone resorption and tooth movement.</td><td>18 C57Bl/6 male mice into 3 groupsof 6 mice: &#187; Control group (vehicle) &#187; 5 mg/kg-1 pamidronate &#187; 10 mg/kg-1OPG</td><td>OPG results in a more powerfulinhibitor of osteoclast recruitment and activity than pamidronate, with areduction of osteoclasts number of 95% and tooth movement of 77%.</td></tr></table>
<table><tr><td>Author</td></tr><tr><td>Dunn M, et al32Michigan,USA 2007</td></tr><tr><td>Keles A, et al31BostonUSA 2007</td></tr></table>
<table><tr><td>Study design</td><td>Aim of the study</td><td>Sample size</td><td>Conclusion</td></tr><tr><td>. Case control</td><td>Assessment of OPG in regulatingmechanically induced bone modeling in a rat model of orthodontic toothmovement.</td><td>39 male Sprague-Dawley rats Β» 9rats without appliances: (3 rats without injections, 3 rats with vehicleand 3 rats with high-dose OPG) Β» 30 rats with orthodontic forces: (10rats with 0.5 mg/Kg OPG-Fc, 10 rats with 5.0 mg/Kg OPG-Fc and 10 ratswith vehicle)</td><td>Local delivery of OPG-Fc inhibitsosteoclastogenesis and tooth movement at targeted dental sites.</td></tr><tr><td>Case control</td><td>Evaluation of the efficacy ofpamidronateversus osteoprotegerin (OPG) in theinhibition of bone resorption and tooth movement.</td><td>18 C57Bl/6 male mice into 3 groupsof 6 mice: Β» Control group (vehicle) Β» 5 mg/kg-1 pamidronate Β» 10 mg/kg-1OPG</td><td>OPG results in a more powerfulinhibitor of osteoclast recruitment and activity than pamidronate, with areduction of osteoclasts number of 95% and tooth movement of 77%.</td></tr></table>
721f9e0f982277474b8c1b92cb5016b915f41dfe838a260d0934f610a035906b.png
simple
<table><tr><td></td><td>UBS time A</td><td>BBS time A</td><td>UBS time B</td><td>BBS time B</td><td>UBS time C</td><td>BBS time C</td><td>UBS time D</td><td>BBS time D</td></tr><tr><td>UBS time A</td><td></td><td>0.43</td><td>0.54</td><td>-</td><td>0.56</td><td>-</td><td>0.55</td><td>-</td></tr><tr><td>BBS time A</td><td>0.43</td><td></td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>0.48</td></tr><tr><td>UBS time B</td><td>0.54</td><td>-</td><td></td><td>0.54</td><td>0.64</td><td>-</td><td>0.56</td><td>-</td></tr><tr><td>BBS time B</td><td>-</td><td>-</td><td>0.54</td><td></td><td>0.42</td><td>0.63</td><td>0.41</td><td>0.50</td></tr><tr><td>UBS time C</td><td>0.56</td><td>-</td><td>0.64</td><td>0.42</td><td></td><td>0.53</td><td>0.69</td><td>-</td></tr><tr><td>BBS time C</td><td>-</td><td>-</td><td>-</td><td>0.63</td><td>0.53</td><td></td><td>0.46</td><td>0.57</td></tr><tr><td>UBS time D</td><td>0.55</td><td>-</td><td>0.56</td><td>0.41</td><td>0.69</td><td>0.46</td><td></td><td>0.54</td></tr><tr><td>BBS time D</td><td>-</td><td>0.48</td><td>-</td><td>0.50</td><td>-</td><td>0.57</td><td>0.54</td><td></td></tr></table>
<table><tr><td></td><td>UBS time A</td><td>BBS time A</td><td>UBS time B</td><td>BBS time B</td><td>UBS time C</td><td>BBS time C</td><td>UBS time D</td><td>BBS time D</td></tr></table>
<table><tr><td>UBS time A</td><td></td><td>0.43</td><td>0.54</td><td>-</td><td>0.56</td><td>-</td><td>0.55</td><td>-</td></tr><tr><td>BBS time A</td><td>0.43</td><td></td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>0.48</td></tr><tr><td>UBS time B</td><td>0.54</td><td>-</td><td></td><td>0.54</td><td>0.64</td><td>-</td><td>0.56</td><td>-</td></tr><tr><td>BBS time B</td><td>-</td><td>-</td><td>0.54</td><td></td><td>0.42</td><td>0.63</td><td>0.41</td><td>0.50</td></tr><tr><td>UBS time C</td><td>0.56</td><td>-</td><td>0.64</td><td>0.42</td><td></td><td>0.53</td><td>0.69</td><td>-</td></tr><tr><td>BBS time C</td><td>-</td><td>-</td><td>-</td><td>0.63</td><td>0.53</td><td></td><td>0.46</td><td>0.57</td></tr><tr><td>UBS time D</td><td>0.55</td><td>-</td><td>0.56</td><td>0.41</td><td>0.69</td><td>0.46</td><td></td><td>0.54</td></tr><tr><td>BBS time D</td><td>-</td><td>0.48</td><td>-</td><td>0.50</td><td>-</td><td>0.57</td><td>0.54</td><td></td></tr></table>
f564c31d8ff5d5ffa45accb3e47f7e940ec0aee7a511713458b7d5c7379fd6d3.png
simple
<table><tr><td>Pattern</td><td>PT (s)</td><td>APTT (s)</td><td>FIB (g/L)</td><td>D-D (ug/ml)</td></tr><tr><td>Dampness-heat accumulation</td><td>12.25 &#177; 1.08</td><td>39.38 &#177; 6.33</td><td>3.65 &#177; 1.08</td><td>2.30 &#177; 0.46<sup><i>&#8727;&#8727;</i></sup></td></tr><tr><td>Liver-kidney yin deficiency</td><td>14.34 &#177; 0.56</td><td>40.81 &#177; 4.75</td><td>2.98 &#177; 0.35</td><td>0.65 &#177; 0.13<sup><i>&#8727;</i></sup></td></tr><tr><td>Qi and yin deficiency</td><td>12.58 &#177; 0.64</td><td>42.13 &#177; 5.05</td><td>3.41 &#177; 0.85</td><td>0.53 &#177; 0.27<sup><i>&#8727;</i></sup></td></tr><tr><td>Blood-heat bleeding</td><td>13.17 &#177; 0.78</td><td>39.13 &#177; 1.96</td><td>3.56 &#177; 0.48</td><td>2.28 &#177; 0.76<sup><i>&#8727;&#8727;</i></sup></td></tr></table>
<table><tr><td>Pattern</td></tr><tr><td>Dampness-heat accumulation</td></tr><tr><td>Liver-kidney yin deficiency</td></tr><tr><td>Qi and yin deficiency</td></tr><tr><td>Blood-heat bleeding</td></tr></table>
<table><tr><td>PT (s)</td><td>APTT (s)</td><td>FIB (g/L)</td><td>D-D (ug/ml)</td></tr><tr><td>12.25 Β± 1.08</td><td>39.38 Β± 6.33</td><td>3.65 Β± 1.08</td><td>2.30 Β± 0.46βˆ—βˆ—</td></tr><tr><td>14.34 Β± 0.56</td><td>40.81 Β± 4.75</td><td>2.98 Β± 0.35</td><td>0.65 Β± 0.13βˆ—</td></tr><tr><td>12.58 Β± 0.64</td><td>42.13 Β± 5.05</td><td>3.41 Β± 0.85</td><td>0.53 Β± 0.27βˆ—</td></tr><tr><td>13.17 Β± 0.78</td><td>39.13 Β± 1.96</td><td>3.56 Β± 0.48</td><td>2.28 Β± 0.76βˆ—βˆ—</td></tr></table>
b5d134b8166feed9f8df2d4c02d2927709a260d28f5619bcf25b937d53c504fa.png
complex
<table><tr><td></td><td colspan="3">Where did you go for the first consultation during the past 30 days</td></tr><tr><td></td><td>Categories</td><td>Frequency</td><td>Percent (%)</td></tr><tr><td>Did not access healthcare (1&#8211;5)</td><td>1 = Drugs at Home</td><td>32</td><td>2.4</td></tr><tr><td rowspan="4"></td><td>2 = Neighbor/Friend</td><td>5</td><td>0.4</td></tr><tr><td>3 = Community health worker</td><td>12</td><td>0.9</td></tr><tr><td>4 = Homapak drug distributor</td><td>1</td><td>0.1</td></tr><tr><td>5 = Ordinary shop</td><td>13</td><td>1.0</td></tr><tr><td rowspan="6">Accessed healthcare (6&#8211;11)</td><td>6 = Drug shop/Pharmacy</td><td>134</td><td>10.1</td></tr><tr><td>7 = Private clinic</td><td>408</td><td>30.9</td></tr><tr><td>8 = Health unit government</td><td>414</td><td>31.3</td></tr><tr><td>9 = Health unit NGO</td><td>48</td><td>3.6</td></tr><tr><td>10 = Hospital government</td><td>160</td><td>12.1</td></tr><tr><td>11 = Hospital NGO</td><td>54</td><td>4.1</td></tr><tr><td rowspan="2">Did not access healthcare (12, 96)</td><td>12 = Traditional healer</td><td>25</td><td>1.9</td></tr><tr><td>96 = Other (specify)</td><td>15</td><td>1.1</td></tr><tr><td></td><td>Total</td><td>1,321</td><td>100</td></tr></table>
<table><tr><td></td><td colspan="3">Where did you go for the first consultation during the pas</td></tr></table>
<table><tr><td></td><td colspan="3">t 30 days</td></tr><tr><td></td><td>Categories</td><td>Frequency</td><td>Percent (%)</td></tr><tr><td>Did not access healthcare (1–5)</td><td>1 = Drugs at Home</td><td>32</td><td>2.4</td></tr><tr><td rowspan="4"></td><td>2 = Neighbor/Friend</td><td>5</td><td>0.4</td></tr><tr><td>3 = Community health worker</td><td>12</td><td>0.9</td></tr><tr><td>4 = Homapak drug distributor</td><td>1</td><td>0.1</td></tr><tr><td>5 = Ordinary shop</td><td>13</td><td>1.0</td></tr><tr><td rowspan="6">Accessed healthcare (6–11)</td><td>6 = Drug shop/Pharmacy</td><td>134</td><td>10.1</td></tr><tr><td>7 = Private clinic</td><td>408</td><td>30.9</td></tr><tr><td>8 = Health unit government</td><td>414</td><td>31.3</td></tr><tr><td>9 = Health unit NGO</td><td>48</td><td>3.6</td></tr><tr><td>10 = Hospital government</td><td>160</td><td>12.1</td></tr><tr><td>11 = Hospital NGO</td><td>54</td><td>4.1</td></tr><tr><td rowspan="2">Did not access healthcare (12, 96)</td><td>12 = Traditional healer</td><td>25</td><td>1.9</td></tr><tr><td>96 = Other (specify)</td><td>15</td><td>1.1</td></tr><tr><td></td><td>Total</td><td>1,321</td><td>100</td></tr></table>
2c2557265d74370ed3ed068fceca7abe7443d03919f7d89c96a86a9c64d01993.png
complex
<table><tr><td>Sample</td><td>Sample</td><td>Library prep/</td><td>Seq</td><td colspan="6"><i>Anabaena</i> sp. genome</td></tr><tr><td></td><td>date</td><td>Seq platform</td><td>output</td><td colspan="6"></td></tr><tr><td></td><td></td><td></td><td>(Gbp)</td><td colspan="6"></td></tr><tr><td></td><td></td><td></td><td></td><td>N50</td><td>Mean</td><td>No.</td><td>Max</td><td>Total</td><td>Unique</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td>cov.</td><td>contigs</td><td>contig</td><td>length</td><td>core</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>(nt)</td><td>(nt)</td><td>genes</td></tr><tr><td><i>Anabaena</i></td><td>Dec</td><td>Blue</td><td colspan="7"></td></tr><tr><td>sp. WA102</td><td>2014</td><td>Pippin/</td><td>1.13</td><td>5,715,573</td><td>50x</td><td>3*</td><td>5,705,437</td><td>5,807,452</td><td>104</td></tr><tr><td>culture</td><td></td><td>PacBio</td><td colspan="7"></td></tr><tr><td>est. from</td><td>Dec</td><td>TruSeq/</td><td colspan="7"></td></tr><tr><td>Anderson</td><td>2013</td><td>HiSeq2000</td><td>3.83</td><td>15,892</td><td>129x</td><td>819</td><td>66,878</td><td>5,698,213</td><td>105</td></tr><tr><td>Lake</td><td></td><td>100bp PE</td><td colspan="7"></td></tr><tr><td>May 2013</td><td colspan="9"></td></tr><tr><td>WA25</td><td>July</td><td>TruSeq/</td><td></td><td>Shotgun</td><td></td><td></td><td colspan="3"></td></tr><tr><td></td><td>2012/</td><td>HiSeq2000</td><td>30.1</td><td>metagenome</td><td colspan="5"></td></tr><tr><td></td><td>Anderson</td><td>100bp PE</td><td></td><td>of surface</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td></td><td>Lake</td><td></td><td></td><td>lake water</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td><i>Anabaena</i></td><td colspan="9"></td></tr><tr><td>sp. AL93</td><td colspan="9"></td></tr><tr><td>culture</td><td>Jan</td><td>Nextera/</td><td colspan="7"></td></tr><tr><td>est. from</td><td>2013</td><td>MiSeq</td><td>1.36</td><td>46,264</td><td>149x</td><td>314</td><td>133,848</td><td>5,757,055</td><td>105</td></tr><tr><td>American</td><td></td><td>250bp PE</td><td colspan="7"></td></tr><tr><td>Lake</td><td colspan="9"></td></tr><tr><td>1993</td><td></td><td></td><td></td><td colspan="6"></td></tr></table>
<table><tr><td>Sample</td><td>Sample</td><td>Library prep/</td><td>Seq</td><td colspan="4">Anabaena sp. genome</td></tr><tr><td></td><td>date</td><td>Seq platform</td><td>output</td><td colspan="4"></td></tr><tr><td></td><td></td><td></td><td>(Gbp)</td><td colspan="4"></td></tr><tr><td></td><td></td><td></td><td></td><td>N50</td><td>Mean</td><td>No.</td><td>Max</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td>cov.</td><td>contigs</td><td>contig</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>(nt)</td></tr><tr><td>Anabaena</td><td>Dec</td><td>Blue</td><td colspan="5"></td></tr><tr><td>sp. WA102</td><td>2014</td><td>Pippin/</td><td>1.13</td><td>5,715,573</td><td>50x</td><td>3*</td><td>5,705,437</td></tr><tr><td>culture</td><td></td><td>PacBio</td><td colspan="5"></td></tr><tr><td>est. from</td><td>Dec</td><td>TruSeq/</td><td colspan="5"></td></tr><tr><td>Anderson</td><td>2013</td><td>HiSeq2000</td><td>3.83</td><td>15,892</td><td>129x</td><td>819</td><td>66,878</td></tr><tr><td>Lake</td><td></td><td>100bp PE</td><td colspan="5"></td></tr><tr><td>May 2013</td><td colspan="7"></td></tr><tr><td>WA25</td><td>July</td><td>TruSeq/</td><td></td><td>Shotgun</td><td></td><td></td><td></td></tr><tr><td></td><td>2012/</td><td>HiSeq2000</td><td>30.1</td><td>metagenome</td><td colspan="3"></td></tr><tr><td></td><td>Anderson</td><td>100bp PE</td><td></td><td>of surface</td><td>-</td><td>-</td><td>-</td></tr><tr><td></td><td>Lake</td><td></td><td></td><td>lake water</td><td></td><td></td><td></td></tr><tr><td>Anabaena</td><td colspan="7"></td></tr><tr><td>sp. AL93</td><td colspan="7"></td></tr><tr><td>culture</td><td>Jan</td><td>Nextera/</td><td colspan="5"></td></tr><tr><td>est. from</td><td>2013</td><td>MiSeq</td><td>1.36</td><td>46,264</td><td>149x</td><td>314</td><td>133,848</td></tr><tr><td>American</td><td></td><td>250bp PE</td><td colspan="5"></td></tr><tr><td>Lake</td><td colspan="7"></td></tr><tr><td>1993</td><td></td><td></td><td></td><td colspan="4"></td></tr></table>
<table><tr><td colspan="2">Anabaena sp. genome</td></tr><tr><td colspan="2"></td></tr><tr><td colspan="2"></td></tr><tr><td>Total</td><td>Unique</td></tr><tr><td>length</td><td>core</td></tr><tr><td>(nt)</td><td>genes</td></tr><tr><td colspan="2"></td></tr><tr><td>5,807,452</td><td>104</td></tr><tr><td colspan="2"></td></tr><tr><td colspan="2"></td></tr><tr><td>5,698,213</td><td>105</td></tr><tr><td colspan="2"></td></tr><tr><td colspan="2"></td></tr><tr><td colspan="2"></td></tr><tr><td colspan="2"></td></tr><tr><td>-</td><td>-</td></tr><tr><td></td><td></td></tr><tr><td colspan="2"></td></tr><tr><td colspan="2"></td></tr><tr><td colspan="2"></td></tr><tr><td>5,757,055</td><td>105</td></tr><tr><td colspan="2"></td></tr><tr><td colspan="2"></td></tr><tr><td colspan="2"></td></tr></table>
c2e419a14b5bac158d301681bb4cc721feb036643bec43212e43b6f45c42ef0e.png
simple
<table><tr><td>Variables</td><td>Adjusted R<sup>2</sup></td><td>Beta</td></tr><tr><td><underline>Block 1: Demographic Variables</underline></td><td>0.07</td><td></td></tr><tr><td>Age</td><td></td><td>0.19***</td></tr><tr><td>Gender (1 = female, 2 = male)</td><td></td><td>-0.08</td></tr><tr><td>Employment status (1 = employed, 2 = unemployed)</td><td></td><td>0.19***</td></tr><tr><td>Source (1 = internet, 2 = paper)</td><td></td><td>0.01</td></tr><tr><td><underline>Block 2: Theory of Planned Behaviour Variables</underline></td><td>0.51</td><td></td></tr><tr><td>Attitude</td><td></td><td>-0.47****</td></tr><tr><td>Subjective norm</td><td></td><td>-0.22****</td></tr><tr><td>Perceived control</td><td></td><td>-0.19***</td></tr><tr><td>Self-efficacy</td><td></td><td>-0.06</td></tr><tr><td><underline>Block 3: Extended Theory of Planned Behaviour Variables</underline></td><td>0.56</td><td></td></tr><tr><td>Anticipated regret</td><td></td><td>-0.19***</td></tr><tr><td>Last year, did you have a vaccination for ordinary seasonal flu?, (1 = yes)</td><td></td><td>-0.04</td></tr><tr><td>Do you intend to have a vaccination for ordinary seasonal flu this year? (1 = yes)</td><td></td><td>-0.14*</td></tr><tr><td>Knowledge</td><td></td><td>0.02</td></tr><tr><td><underline>Block 4: Health Belief Model Variables</underline></td><td>0.60</td><td></td></tr><tr><td>Perceived susceptibility</td><td></td><td>0.01</td></tr><tr><td>Perceived severity</td><td></td><td>-0.06</td></tr><tr><td><i>Perceived benefits:</i></td><td></td><td></td></tr><tr><td>Vaccination is a good idea because I feel less worried about catching swine flu</td><td></td><td>0.07</td></tr><tr><td>Vaccination decreases my chance of getting swine flu or its complications</td><td></td><td>-0.24***</td></tr><tr><td>If I get vaccinated for swine fu, I will decrease the frequency of having to consult my doctor</td><td></td><td>-0.12**</td></tr><tr><td><i>Perceived barriers:</i></td><td></td><td></td></tr><tr><td>The side-effects of swine flu vaccination interfere with my usual activities</td><td></td><td>-0.04</td></tr><tr><td>I am scared of needles</td><td></td><td>0.05</td></tr><tr><td>I cannot be bothered to get a swine flu vaccination</td><td></td><td>0.13***</td></tr></table>
<table><tr><td>Variables</td><td>Adjusted R2</td><td>Beta</td></tr><tr><td>Block 1: Demographic Variables</td><td>0.07</td><td></td></tr><tr><td>Age</td><td></td><td>0.19***</td></tr><tr><td>Gender (1 = female, 2 = male)</td><td></td><td>-0.08</td></tr><tr><td>Employment status (1 = employed, 2 = unemployed)</td><td></td><td>0.19***</td></tr><tr><td>Source (1 = internet, 2 = paper)</td><td></td><td>0.01</td></tr><tr><td>Block 2: Theory of Planned Behaviour Variables</td><td>0.51</td><td></td></tr><tr><td>Attitude</td><td></td><td>-0.47****</td></tr><tr><td>Subjective norm</td><td></td><td>-0.22****</td></tr><tr><td>Perceived control</td><td></td><td>-0.19***</td></tr><tr><td>Self-efficacy</td><td></td><td>-0.06</td></tr><tr><td>Block 3: Extended Theory of Planned Behaviour Variables</td><td>0.56</td><td></td></tr><tr><td>Anticipated regret</td><td></td><td>-0.19***</td></tr><tr><td>Last year, did you have a vaccination for ordinary seasonal flu?, (1 = yes)</td><td></td><td>-0.04</td></tr><tr><td>Do you intend to have a vaccination for ordinary seasonal flu this year? (1 = yes)</td><td></td><td>-0.14*</td></tr><tr><td>Knowledge</td><td></td><td>0.02</td></tr><tr><td>Block 4: Health Belief Model Variables</td><td>0.60</td><td></td></tr><tr><td>Perceived susceptibility</td><td></td><td>0.01</td></tr><tr><td>Perceived severity</td><td></td><td>-0.06</td></tr><tr><td>Perceived benefits:</td><td></td><td></td></tr><tr><td>Vaccination is a good idea because I feel less worried about catching swine flu</td><td></td><td>0.07</td></tr><tr><td>Vaccination decreases my chance of getting swine flu or its complications</td><td></td><td>-0.24***</td></tr><tr><td>If I get vaccinated for swine fu, I will decrease the frequency of having to consult my doctor</td><td></td><td>-0.12**</td></tr><tr><td>Perceived barriers:</td><td></td><td></td></tr><tr><td>The side-effects of swine flu vaccination interfere with my usual activities</td><td></td><td>-0.04</td></tr><tr><td>I am</td><td></td><td></td></tr></table>
<table><tr><td>Variables</td><td>Adjusted R2</td><td>Beta</td></tr><tr><td> scared of needles</td><td></td><td>0.05</td></tr><tr><td>I cannot be bothered to get a swine flu vaccination</td><td></td><td>0.13***</td></tr></table>
7cedc65effdc3d7d06bad09371fd6f11bfb03aa7265bcac38353aba09de25a14.png
complex
<table><tr><td rowspan="2">Radiographs &amp; event forms</td><td colspan="3">Pre-surgery</td><td>Surgery</td><td colspan="9">Post-surgery</td></tr><tr><td>Screening</td><td>Enrolment</td><td>Baseline</td><td>(Day 0)</td><td>&#8804; 48 hrs Post surgery</td><td>D/C</td><td>1 wk (24 hrs-10 ds)</td><td>10 wk (8-12 wks)</td><td>6 mo (5-7 mos)</td><td>9 mo (8-10 mos)</td><td>12 mo (11-13 mos)</td><td>18 mo (17-19 mos)</td><td>24 mo (&#8805;24 mos)</td></tr><tr><td>Radiographs</td><td> </td><td> </td><td>&#9679;</td><td> </td><td>&#9679;</td><td> </td><td> </td><td>&#9679;</td><td> </td><td> </td><td>&#9679;</td><td> </td><td>&#9679;</td></tr><tr><td>Screening</td><td>&#9679;</td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>Informed consent</td><td> </td><td>&#9679;</td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>Randomization</td><td> </td><td>&#9679;</td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>Baseline</td><td> </td><td> </td><td>&#9679;</td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>Patient contact</td><td> </td><td>&#9679;</td><td> </td><td> </td><td>&#9679;</td><td>&#9679;</td><td>&#9679;</td><td>&#9679;</td><td>&#9679;</td><td>&#9679;</td><td>&#9679;</td><td>&#9679;</td><td>&#9679;</td></tr><tr><td>Pre-Op care</td><td> </td><td> </td><td>&#9679;</td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>Fracture characteristics</td><td> </td><td> </td><td>&#9679;</td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>Surgical report</td><td> </td><td> </td><td> </td><td>&#9679;</td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>Post-Op care</td><td> </td><td> </td><td> </td><td> </td><td>&#9679;</td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>Clinic or telephone follow-up</td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td>&#9679;</td><td>&#9679;</td><td>&#9679;</td><td>&#9679;</td><td>&#9679;</td><td>&#9679;</td><td>&#9679;</td></tr><tr><td>RS</td><td> </td><td> </td><td> </td><td> </td><td>*</td><td> </td><td>*</td><td>*</td><td>*</td><td>*</td><td>*</td><td>*</td><td>*</td></tr><tr><td>AE</td><td> </td><td> </td><td> </td><td>*</td><td>*</td><td> </td><td>*</td><td>*</td><td>*</td><td>*</td><td>*</td><td>*</td><td>*</td></tr><tr><td>Hospital D/C</td><td> </td><td> </td><td> </td><td> </td><td> </td><td>&#9679;</td><td>*</td><td>*</td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>Missed</td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>Follow-up</td><td> </td><td> </td><td> </td><td> </td><td> </td><td>*</td><td>*</td><td>*</td><td>*</td><td>*</td><td>*</td><td>*</td><td> </td></tr><tr><td>Early W/D</td><td> </td><td> </td><td> </td><td> </td><td> </td><td>*</td><td>*</td><td>*</td><td>*</td><td>*</td><td>*</td><td>*</td><td>*</td></tr></table>
<table><tr><td rowspan="2">Radiographs & event forms</td><td colspan="2">Pre-surgery</td></tr><tr><td>Screening</td><td>Enrolment</td></tr><tr><td>Radiographs</td><td></td><td></td></tr><tr><td>Screening</td><td>●</td><td></td></tr><tr><td>Informed consent</td><td></td><td>●</td></tr><tr><td>Randomization</td><td></td><td>●</td></tr><tr><td>Baseline</td><td></td><td></td></tr><tr><td>Patient contact</td><td></td><td>●</td></tr><tr><td>Pre-Op care</td><td></td><td></td></tr><tr><td>Fracture characteristics</td><td></td><td></td></tr><tr><td>Surgical report</td><td></td><td></td></tr><tr><td>Post-Op care</td><td></td><td></td></tr><tr><td>Clinic or telephone follow-up</td><td></td><td></td></tr><tr><td>RS</td><td></td><td></td></tr><tr><td>AE</td><td></td><td></td></tr><tr><td>Hospital D/C</td><td></td><td></td></tr><tr><td>Missed</td><td></td><td></td></tr><tr><td>Follow-up</td><td></td><td></td></tr><tr><td>Early W/D</td><td></td><td></td></tr></table>
<table><tr><td>Pre-surgery</td><td>Surgery</td><td colspan="9">Post-surgery</td></tr><tr><td>Baseline</td><td>(Day 0)</td><td>≀ 48 hrs Post surgery</td><td>D/C</td><td>1 wk (24 hrs-10 ds)</td><td>10 wk (8-12 wks)</td><td>6 mo (5-7 mos)</td><td>9 mo (8-10 mos)</td><td>12 mo (11-13 mos)</td><td>18 mo (17-19 mos)</td><td>24 mo (β‰₯24 mos)</td></tr><tr><td>●</td><td></td><td>●</td><td></td><td></td><td>●</td><td></td><td></td><td>●</td><td></td><td>●</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>●</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td>●</td><td>●</td><td>●</td><td>●</td><td>●</td><td>●</td><td>●</td><td>●</td><td>●</td></tr><tr><td>●</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>●</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td>●</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td>●</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td></td><td></td><td>●</td><td>●</td><td>●</td><td>●</td><td>●</td><td>●</td><td>●</td></tr><tr><td></td><td></td><td>*</td><td></td><td>*</td><td>*</td><td>*</td><td>*</td><td>*</td><td>*</td><td>*</td></tr><tr><td></td><td>*</td><td>*</td><td></td><td>*</td><td>*</td><td>*</td><td>*</td><td>*</td><td>*</td><td>*</td></tr><tr><td></td><td></td><td></td><td>●</td><td>*</td><td>*</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td></td><td>*</td><td>*</td><td>*</td><td>*</td><td>*</td><td>*</td><td>*</td><td></td></tr><tr><td></td><td></td><td></td><td>*</td><td>*</td><td>*</td><td>*</td><td>*</td><td>*</td><td>*</td><td>*</td></tr></table>
9baaa740657a6c2dcc0dedf4de91cbb0310631a76da1e31a4f53c7bafb4cfba9.png
simple
<table><tr><td>Gene</td><td>Forward Primer</td><td>Reverse Primer</td><td>Product Size (bp)</td></tr><tr><td>AFP</td><td>CACTGCTGCAACTCTTCGTA</td><td>CTTTGGACCCTCTTCTGTGA</td><td>300</td></tr><tr><td>Alb</td><td>GACAAGGAAAGCTGCCTGAC</td><td>TTCTGCAAAGTCAGCATTGG</td><td>174</td></tr><tr><td>Trf</td><td>ACCATGTTGTGGTCTCACGA</td><td>ACAGAAGGTCCTTGGTGGTG</td><td>135</td></tr><tr><td>CPS</td><td>AGGATGTCAAGGTGTTTGGC</td><td>GCTTAACTAGCAGGCGGATG</td><td> 93</td></tr><tr><td>&#946;-actin</td><td>GACCTCTATGCCAACACAGT</td><td>AGTACTTGCGCTCAGGAGGA</td><td>139</td></tr></table>
<table><tr><td>Gene</td><td>Forward Primer</td><td>Reverse Primer</td></tr><tr><td>AFP</td><td>CACTGCTGCAACTCTTCGTA</td><td>CTTTGGACCCTCTTCTGTGA</td></tr><tr><td>Alb</td><td>GACAAGGAAAGCTGCCTGAC</td><td>TTCTGCAAAGTCAGCATTGG</td></tr><tr><td>Trf</td><td>ACCATGTTGTGGTCTCACGA</td><td>ACAGAAGGTCCTTGGTGGTG</td></tr><tr><td>CPS</td><td>AGGATGTCAAGGTGTTTGGC</td><td>GCTTAACTAGCAGGCGGATG</td></tr><tr><td>Ξ²-actin</td><td>GACCTCTATGCCAACACAGT</td><td>AGTACTTGCGCTCAGGAGGA</td></tr></table>
<table><tr><td>Product Size (bp)</td></tr><tr><td>300</td></tr><tr><td>174</td></tr><tr><td>135</td></tr><tr><td>93</td></tr><tr><td>139</td></tr></table>
68d79680d34265a478554dd5d10192e58b9e2d0e224325269752b2da480153d1.png
complex
<table><tr><td>Predictor</td><td><i>B</i></td><td><i>OR [95% CI]</i></td><td><i>p</i></td></tr><tr><td>Detect (DL and DnL)</td><td colspan="3"></td></tr><tr><td colspan="4"> Response time</td></tr><tr><td>Accuracy</td><td>0.13</td><td>1.14 [1.10, 1.18]</td><td>&lt;0.001</td></tr><tr><td><i>d'</i></td><td>&#8722;0.01</td><td>0.99 [0.98, 1.01]</td><td>0.40</td></tr><tr><td><i>c</i></td><td>0.004</td><td>1.00 [0.99, 1.01]</td><td>0.42</td></tr><tr><td colspan="4"> General belief about percentage of images manipulated = High (71&#8211;100%)</td></tr><tr><td>Accuracy</td><td>0.16</td><td>1.18 [1.02, 1.36]</td><td>0.03</td></tr><tr><td><i>d'</i></td><td>0.09</td><td>1.09 [0.97, 1.23]</td><td>0.14</td></tr><tr><td><i>c</i></td><td>&#8722;0.04</td><td>0.96 [0.90, 1.03]</td><td>0.25</td></tr><tr><td colspan="4"> Gender = Female</td></tr><tr><td>Accuracy</td><td>&#8722;0.01</td><td>0.99 [0.86, 1.15]</td><td>0.92</td></tr><tr><td><i>d'</i></td><td>&#8722;0.03</td><td>0.97 [0.86, 1.09]</td><td>0.60</td></tr><tr><td><i>c</i></td><td>&#8722;0.01</td><td>0.99 [0.93, 1.06]</td><td>0.82</td></tr><tr><td colspan="4"> Interest in photography = Interested</td></tr><tr><td>Accuracy</td><td>0.17</td><td>1.19 [1.02, 1.39]</td><td>0.03</td></tr><tr><td><i>d'</i></td><td>0.04</td><td>1.04 [0.92, 1.18]</td><td>0.56</td></tr><tr><td><i>c</i></td><td>&#8722;0.05</td><td>0.95 [0.89, 1.02]</td><td>0.18</td></tr><tr><td colspan="4"> Frequency of taking photos = Daily/weekly</td></tr><tr><td>Accuracy</td><td>&#8722;0.01</td><td>0.99 [0.84, 1.17]</td><td>0.91</td></tr><tr><td><i>d'</i></td><td>&#8722;0.07</td><td>0.93 [0.82, 1.07]</td><td>0.31</td></tr><tr><td><i>c</i></td><td>&#8722;0.05</td><td>0.95 [0.88, 1.02]</td><td>0.18</td></tr><tr><td>Locate (DL and nDL)</td><td colspan="3"></td></tr><tr><td> Response time</td><td>0.10</td><td>1.11 [1.08, 1.14]</td><td>&lt;0.001</td></tr><tr><td> General belief about percentage of images manipulated = High (71&#8211;100%)</td><td>&#8722;0.01</td><td>0.99 [0.87, 1.12]</td><td>0.84</td></tr><tr><td> Gender = Female</td><td>&#8722;0.10</td><td>0.91 [0.80, 1.03]</td><td>0.14</td></tr><tr><td> Interest in photography = Interested</td><td>0.16</td><td>1.17 [1.02, 1.34]</td><td>0.02</td></tr><tr><td> Frequency of taking photos = Daily/weekly</td><td>&#8722;0.08</td><td>0.92 [0.80, 1.06]</td><td>0.27</td></tr><tr><td>Detect and locate (DL)</td><td colspan="3"></td></tr><tr><td> Response time: detect</td><td>0.17</td><td>1.19 [1.15, 1.23]</td><td>&lt;0.001</td></tr><tr><td> Response time: locate</td><td>0.13</td><td>1.14 [1.11, 1.18]</td><td>&lt;0.001</td></tr><tr><td> General belief about percentage of images manipulated = High (71&#8211;100%)</td><td>0.05</td><td>1.05 [0.91, 1.20]</td><td>0.51</td></tr><tr><td> Gender = Female</td><td>&#8722;0.13</td><td>0.88 [0.77, 1.01]</td><td>0.07</td></tr><tr><td> Interest in photography = Interested</td><td>0.20</td><td>1.22 [1.06, 1.41]</td><td>0.01</td></tr><tr><td> Frequency of taking photos = Daily/weekly</td><td>&#8722;0.09</td><td>0.92 [0.78, 1.07]</td><td>0.28</td></tr></table>
<table><tr><td>Predictor</td><td>B</td><td>OR [95% CI]</td><td>p</td></tr><tr><td>Detect (DL and DnL)</td><td colspan="3"></td></tr><tr><td colspan="4">Response time</td></tr><tr><td>Accuracy</td><td>0.13</td><td>1.14 [1.10, 1.18]</td><td><0.001</td></tr><tr><td>d'</td><td>βˆ’0.01</td><td>0.99 [0.98, 1.01]</td><td>0.40</td></tr><tr><td>c</td><td>0.004</td><td>1.00 [0.99, 1.01]</td><td>0.42</td></tr><tr><td colspan="4">General belief about percentage of images manipulated = High (71–100%)</td></tr><tr><td>Accuracy</td><td>0.16</td><td>1.18 [1.02, 1.36]</td><td>0.03</td></tr><tr><td>d'</td><td>0.09</td><td>1.09 [0.97, 1.23]</td><td>0.14</td></tr></table>
<table><tr><td>Predictor</td><td>B</td><td>OR [95% CI]</td><td>p</td></tr><tr><td>c</td><td>βˆ’0.04</td><td>0.96 [0.90, 1.03]</td><td>0.25</td></tr><tr><td colspan="4">Gender = Female</td></tr><tr><td>Accuracy</td><td>βˆ’0.01</td><td>0.99 [0.86, 1.15]</td><td>0.92</td></tr><tr><td>d'</td><td>βˆ’0.03</td><td>0.97 [0.86, 1.09]</td><td>0.60</td></tr><tr><td>c</td><td>βˆ’0.01</td><td>0.99 [0.93, 1.06]</td><td>0.82</td></tr><tr><td colspan="4">Interest in photography = Interested</td></tr><tr><td>Accuracy</td><td>0.17</td><td>1.19 [1.02, 1.39]</td><td>0.03</td></tr><tr><td>d'</td><td>0.04</td><td>1.04 [0.92, 1.18]</td><td>0.56</td></tr><tr><td>c</td><td>βˆ’0.05</td><td>0.95 [0.89, 1.02]</td><td>0.18</td></tr><tr><td colspan="4">Frequency of taking photos = Daily/weekly</td></tr><tr><td>Accuracy</td><td>βˆ’0.01</td><td>0.99 [0.84, 1.17]</td><td>0.91</td></tr><tr><td>d'</td><td>βˆ’0.07</td><td>0.93 [0.82, 1.07]</td><td>0.31</td></tr><tr><td>c</td><td>βˆ’0.05</td><td>0.95 [0.88, 1.02]</td><td>0.18</td></tr><tr><td>Locate (DL and nDL)</td><td colspan="3"></td></tr><tr><td>Response time</td><td>0.10</td><td>1.11 [1.08, 1.14]</td><td><0.001</td></tr><tr><td>General belief about percentage of images manipulated = High (71–100%)</td><td>βˆ’0.01</td><td>0.99 [0.87, 1.12]</td><td>0.84</td></tr><tr><td>Gender = Female</td><td>βˆ’0.10</td><td>0.91 [0.80, 1.03]</td><td>0.14</td></tr><tr><td>Interest in photography = Interested</td><td>0.16</td><td>1.17 [1.02, 1.34]</td><td>0.02</td></tr><tr><td>Frequency of taking photos = Daily/weekly</td><td>βˆ’0.08</td><td>0.92 [0.80, 1.06]</td><td>0.27</td></tr><tr><td>Detect and locate (DL)</td><td colspan="3"></td></tr><tr><td>Response time: detect</td><td>0.17</td><td>1.19 [1.15, 1.23]</td><td><0.001</td></tr><tr><td>Response time: locate</td><td>0.13</td><td>1.14 [1.11, 1.18]</td><td><0.001</td></tr><tr><td>General belief about percentage of images manipulated = High (71–100%)</td><td>0.05</td><td>1.05 [0.91, 1.20]</td><td>0.51</td></tr><tr><td>Gender = Female</td><td>βˆ’0.13</td><td>0.88 [0.77, 1.01]</td><td>0.07</td></tr><tr><td>Interest in photography = Interested</td><td>0.20</td><td>1.22 [1.06, 1.41]</td><td>0.01</td></tr><tr><td>Frequency of taking photos = Daily/weekly</td><td>βˆ’0.09</td><td>0.92 [0.78, 1.07]</td><td>0.28</td></tr></table>
b41af71b2e3acd219a5298c06ecb20bc635ed83972c3765e5d402efc4f179b84.png
complex
<table><tr><td> </td><td>Male</td><td>Female</td><td>P-value</td></tr><tr><td>Number of patients</td><td>110</td><td>51</td><td> </td></tr><tr><td>Age (mean, SD)</td><td>36 (10.3)</td><td>40 (10.0)</td><td>0.013</td></tr><tr><td>Age of onset (median, range)</td><td>20 (12&#8211;39)</td><td>25 (13&#8211;48)</td><td>0.057</td></tr><tr><td>Psychiatric hospital admissions (median, range)</td><td>6 (1&#8211;24)</td><td>4 (0&#8211;20)</td><td>0.091</td></tr><tr><td>Suicide attempts (median, range)</td><td>0 (0&#8211;6)</td><td>0 (0&#8211;5)</td><td>0.674</td></tr><tr><td>Years of evolution of disease (median, range)</td><td>13 (0&#8211;45)</td><td>11 (0&#8211;49)</td><td>0.578</td></tr><tr><td>Marital status (N, percentage)</td><td> </td><td> </td><td> </td></tr><tr><td> Single</td><td>95 (87%)</td><td>32 (62%)</td><td rowspan="4">0.002</td></tr><tr><td> Married or paired</td><td>7 (6%)</td><td>12 (23%)</td></tr><tr><td> Separated or divorced</td><td>8 (7%)</td><td>5 (11%)</td></tr><tr><td> Widowed</td><td>0 (0%)</td><td>2 (4%)</td></tr><tr><td>Drug abuse (N, percentage)</td><td>81 (74%)</td><td>33 (65%)</td><td>0.246</td></tr></table>
<table><tr><td></td><td>Male</td><td>Female</td><td>P-value</td></tr><tr><td>Number of patients</td><td>110</td><td>51</td><td></td></tr><tr><td>Age (mean, SD)</td><td>36 (10.3)</td><td>40 (10.0)</td><td>0.013</td></tr><tr><td>Age of onset (median, range)</td><td>20 (12–39)</td><td>25 (13–48)</td><td>0.057</td></tr><tr><td>Psychiatric hospital admissions (median, range)</td><td>6 (1–24)</td><td>4 (0–20)</td><td>0.091</td></tr><tr><td>Suicide attempts (median, range)</td><td>0 (0–6)</td><td>0 (0–5)</td><td>0.674</td></tr><tr><td>Years of evolution of disease (median, range)</td><td>13 (0–45)</td><td>11 (0–49)</td><td>0.578</td></tr><tr><td>Marital status (N, percentage)</td><td></td><td></td><td></td></tr></table>
<table><tr><td></td><td>Male</td><td>Female</td><td>P-value</td></tr><tr><td>Single</td><td>95 (87%)</td><td>32 (62%)</td><td rowspan="4">0.002</td></tr><tr><td>Married or paired</td><td>7 (6%)</td><td>12 (23%)</td></tr><tr><td>Separated or divorced</td><td>8 (7%)</td><td>5 (11%)</td></tr><tr><td>Widowed</td><td>0 (0%)</td><td>2 (4%)</td></tr><tr><td>Drug abuse (N, percentage)</td><td>81 (74%)</td><td>33 (65%)</td><td>0.246</td></tr></table>
a2f237e7281196ae401e6533e55b8ca535101d6994c80123ac042f1ce890c88f.png
complex
<table><tr><td> </td><td colspan="7">Red clade</td><td colspan="7">Green clade</td><td colspan="7">Black clade</td><td> </td></tr><tr><td> </td><td>CabpIAP</td><td>IAP31</td><td>IAP44</td><td>IAP51</td><td>IAP77</td><td>IAP90</td><td>IAP110</td><td>IAP176</td><td>IAP182</td><td>IAP186</td><td>IAP195</td><td>IAP236</td><td>*IAP281Y</td><td>IAP268</td><td>IAP506</td><td>IAP655</td><td>IAP1112</td><td>IAP1248</td><td>IAP1252</td><td>IAP1259</td><td>IAP1334</td><td>Average</td></tr><tr><td>Mouse 1</td><td>74</td><td>52</td><td>70</td><td>77</td><td>60</td><td>80</td><td>71</td><td>69</td><td>70</td><td>61</td><td>70</td><td>62</td><td> </td><td>77</td><td>77</td><td>76</td><td>66</td><td>LOD</td><td>83</td><td>82</td><td>88</td><td>72</td></tr><tr><td>Mouse 2</td><td>77</td><td>60</td><td>77</td><td>75</td><td>60</td><td>71</td><td>72</td><td>60</td><td>71</td><td>68</td><td>76</td><td>68</td><td> </td><td>84</td><td>86</td><td>70</td><td>69</td><td>83</td><td>77</td><td>78</td><td>86</td><td>73</td></tr><tr><td>Mouse 3</td><td>81</td><td>57</td><td>77</td><td>78</td><td>66</td><td>76</td><td>72</td><td>66</td><td>74</td><td>55</td><td>73</td><td>67</td><td> </td><td>76</td><td>71</td><td>76</td><td>68</td><td>84</td><td>78</td><td>84</td><td>LOD</td><td>72</td></tr><tr><td>Mouse 4</td><td>72</td><td>61</td><td>80</td><td>77</td><td>65</td><td>68</td><td>69</td><td>56</td><td>77</td><td>56</td><td>54</td><td>65</td><td> </td><td>73</td><td>82</td><td>70</td><td>60</td><td>89</td><td>80</td><td>81</td><td>86</td><td>71</td></tr><tr><td>Mouse 5</td><td>74</td><td>59</td><td>71</td><td>78</td><td>61</td><td>80</td><td>75</td><td>65</td><td>70</td><td>69</td><td>69</td><td>63</td><td> </td><td>80</td><td>81</td><td>70</td><td>LOD</td><td>76</td><td>78</td><td>82</td><td>90</td><td>73</td></tr><tr><td>Mouse 6</td><td>76</td><td>57</td><td>78</td><td>74</td><td>65</td><td>73</td><td>71</td><td>63</td><td>64</td><td>67</td><td>76</td><td>58</td><td>64</td><td>77</td><td>94</td><td>76</td><td>63</td><td>78</td><td>LOD</td><td>85</td><td>86</td><td>72</td></tr><tr><td>Mouse 7</td><td>66</td><td>62</td><td>80</td><td>75</td><td>61</td><td>73</td><td>78</td><td>54</td><td>67</td><td>65</td><td>64</td><td>66</td><td> </td><td>75</td><td>75</td><td>74</td><td>60</td><td>85</td><td>78</td><td>82</td><td>86</td><td>71</td></tr><tr><td>Mouse 8</td><td>76</td><td>60</td><td>75</td><td>78</td><td>62</td><td>72</td><td>64</td><td>63</td><td>71</td><td>65</td><td>73</td><td>60</td><td> </td><td>78</td><td>93</td><td>70</td><td>62</td><td>81</td><td>79</td><td>84</td><td>LOD</td><td>72</td></tr><tr><td>Mouse 9</td><td>67</td><td>62</td><td>83</td><td>73</td><td>64</td><td>70</td><td>67</td><td>69</td><td>75</td><td>69</td><td>74</td><td>63</td><td>67</td><td>76</td><td>76</td><td>74</td><td>68</td><td>87</td><td>83</td><td>86</td><td>86</td><td>73</td></tr><tr><td>Mouse 10</td><td>82</td><td>62</td><td>80</td><td>47</td><td>68</td><td>69</td><td>57</td><td>57</td><td>78</td><td>73</td><td>65</td><td>58</td><td> </td><td>82</td><td>92</td><td>79</td><td>60</td><td>84</td><td>82</td><td>81</td><td>91</td><td>72</td></tr><tr><td>Mouse 11</td><td>70</td><td>60</td><td>87</td><td>69</td><td>65</td><td>71</td><td>73</td><td>65</td><td>70</td><td>68</td><td>72</td><td>54</td><td>64</td><td>80</td><td>76</td><td>73</td><td>63</td><td>87</td><td>87</td><td>84</td><td>90</td><td>73</td></tr><tr><td>Mouse 12</td><td>48</td><td>61</td><td>77</td><td>70</td><td>66</td><td>71</td><td>57</td><td>63</td><td>74</td><td>71</td><td>76</td><td>64</td><td>61</td><td>84</td><td>94</td><td>75</td><td>64</td><td>81</td><td>82</td><td>81</td><td>89</td><td>72</td></tr><tr><td>Mouse 13</td><td>79</td><td>64</td><td>81</td><td>73</td><td>64</td><td>69</td><td>66</td><td>67</td><td>69</td><td>68</td><td>75</td><td>62</td><td>64</td><td>80</td><td>81</td><td>72</td><td>66</td><td>LOD</td><td>77</td><td>84</td><td>86</td><td>72</td></tr><tr><td>Mouse 14</td><td>79</td><td>58</td><td>79</td><td>72</td><td>68</td><td>76</td><td>57</td><td>63</td><td>69</td><td>68</td><td>78</td><td>71</td><td> </td><td>79</td><td>82</td><td>77</td><td>69</td><td>84</td><td>84</td><td>84</td><td>90</td><td>74</td></tr><tr><td>Mouse 15</td><td>74</td><td>55</td><td>80</td><td>75</td><td>68</td><td>74</td><td>71</td><td>60</td><td>72</td><td>66</td><td>71</td><td>60</td><td> </td><td>81</td><td>80</td><td>71</td><td>64</td><td>83</td><td>84</td><td>85</td><td>89</td><td>73</td></tr><tr><td>Mouse 16</td><td>73</td><td>56</td><td>81</td><td>71</td><td>70</td><td>69</td><td>48</td><td>60</td><td>83</td><td>71</td><td>75</td><td>67</td><td>57</td><td>83</td><td>74</td><td>73</td><td>66</td><td>82</td><td>79</td><td>85</td><td>88</td><td>72</td></tr><tr><td>Mouse 17</td><td>76</td><td>59</td><td>71</td><td>78</td><td>62</td><td>78</td><td>72</td><td>66</td><td>66</td><td>67</td><td>68</td><td>65</td><td>65</td><td>78</td><td>LOD</td><td>77</td><td>65</td><td>82</td><td>79</td><td>83</td><td>91</td><td>72</td></tr><tr><td>mean</td><td>73</td><td>59</td><td>78</td><td>73</td><td>64</td><td>73</td><td>67</td><td>63</td><td>72</td><td>66</td><td>71</td><td>63</td><td>63</td><td>79</td><td>82</td><td>74</td><td>65</td><td>83</td><td>81</td><td>83</td><td>88</td><td>72</td></tr><tr><td>median</td><td>74</td><td>60</td><td>79</td><td>75</td><td>65</td><td>72</td><td>71</td><td>63</td><td>71</td><td>68</td><td>73</td><td>63</td><td>64</td><td>79</td><td>81</td><td>74</td><td>65</td><td>83</td><td>80</td><td>84</td><td>88</td><td>72</td></tr><tr><td>stdev</td><td>8</td><td>3</td><td>4</td><td>7</td><td>3</td><td>4</td><td>8</td><td>4</td><td>5</td><td>5</td><td>6</td><td>4</td><td>3</td><td>3</td><td>8</td><td>3</td><td>3</td><td>3</td><td>3</td><td>2</td><td>2</td><td>1</td></tr><tr><td>min</td><td>48</td><td>52</td><td>70</td><td>47</td><td>60</td><td>68</td><td>48</td><td>54</td><td>64</td><td>55</td><td>54</td><td>54</td><td>57</td><td>73</td><td>71</td><td>70</td><td>60</td><td>76</td><td>77</td><td>78</td><td>86</td><td>71</td></tr><tr><td>max</td><td>82</td><td>64</td><td>87</td><td>78</td><td>70</td><td>80</td><td>78</td><td>69</td><td>83</td><td>73</td><td>78</td><td>71</td><td>67</td><td>84</td><td>94</td><td>79</td><td>69</td><td>89</td><td>87</td><td>86</td><td>91</td><td>74</td></tr><tr><td>range</td><td>34</td><td>12</td><td>17</td><td>31</td><td>10</td><td>12</td><td>30</td><td>15</td><td>19</td><td>18</td><td>25</td><td>18</td><td>11</td><td>11</td><td>24</td><td>9</td><td>10</td><td>13</td><td>10</td><td>8</td><td>5</td><td>3</td></tr></table>
<table><tr><td></td><td colspan="7">Red clade</td><td colspan="7">Green clade</td><td colspan="7">Black clade</td><td></td></tr><tr><td></td><td>CabpIAP</td><td>IAP31</td><td>IAP44</td><td>IAP51</td><td>IAP77</td><td>IAP90</td><td>IAP110</td><td>IAP176</td><td>IAP182</td><td>IAP186</td><td>IAP195</td><td>IAP236</td><td>*IAP281Y</td><td>IAP268</td><td>IAP506</td><td>IAP655</td><td>IAP1112</td><td>IAP1248</td><td>IAP1252</td><td>IAP1259</td><td>IAP1334</td><td>Average</td></tr><tr><td>Mouse 1</td><td>74</td><td>52</td><td>70</td><td>77</td><td>60</td><td>80</td><td>71</td><td>69</td><td>70</td><td>61</td><td>70</td><td>62</td><td></td><td>77</td><td>77</td><td>76</td><td>66</td><td>LOD</td><td>83</td><td>82</td><td>88</td><td>72</td></tr><tr><td>Mouse 2</td><td>77</td><td>60</td><td>77</td><td>75</td><td>60</td><td>71</td><td>72</td><td>60</td><td>71</td><td>68</td><td>76</td><td>68</td><td></td><td>84</td><td>86</td><td>70</td><td>69</td><td>83</td><td>77</td><td>78</td><td>86</td><td>73</td></tr><tr><td>Mouse 3</td><td>81</td><td>57</td><td>77</td><td>78</td><td>66</td><td>76</td><td>72</td><td>66</td><td>74</td><td>55</td><td>73</td><td>67</td><td></td><td>76</td><td>71</td><td>76</td><td>68</td><td>84</td><td>78</td><td>84</td><td>LOD</td><td>72</td></tr><tr><td>Mouse 4</td><td>72</td><td>61</td><td>80</td><td>77</td><td>65</td><td>68</td><td>69</td><td>56</td><td>77</td><td>56</td><td>54</td><td>65</td><td></td><td>73</td><td>82</td><td>70</td><td>60</td><td>89</td><td>80</td><td>81</td><td>86</td><td>71</td></tr><tr><td>Mouse 5</td><td>74</td><td>59</td><td>71</td><td>78</td><td>61</td><td>80</td><td>75</td><td>65</td><td>70</td><td>69</td><td>69</td><td>63</td><td></td><td>80</td><td>81</td><td>70</td><td>LOD</td><td>76</td><td>78</td><td>82</td><td>90</td><td>73</td></tr><tr><td>Mouse 6</td><td>76</td><td>57</td><td>78</td><td>74</td><td>65</td><td>73</td><td>71</td><td>63</td><td>64</td><td>67</td><td>76</td><td>58</td><td>64</td><td>77</td><td>94</td><td>76</td><td>63</td><td>78</td><td>LOD</td><td>85</td><td>86</td><td>72</td></tr><tr><td>Mouse 7</td><td>66</td><td>62</td><td>80</td><td>75</td><td>61</td><td>73</td><td>78</td><td>54</td><td>67</td><td>65</td><td>64</td><td>66</td><td></td><td>75</td><td>75</td><td>74</td><td>60</td><td>85</td><td>78</td><td>82</td><td>86</td><td>71</td></tr><tr><td>Mouse 8</td><td>76</td><td>60</td><td>75</td><td>78</td><td>62</td><td>72</td><td>64</td><td>63</td><td>71</td><td>65</td><td>73</td><td>60</td><td></td><td>78</td><td>93</td><td>70</td><td>62</td><td>81</td><td>79</td><td>84</td><td>LOD</td><td>72</td></tr><tr><td>Mouse 9</td><td>67</td><td>62</td><td>83</td><td>73</td><td>64</td><td>70</td><td>67</td><td>69</td><td>75</td><td>69</td><td>74</td><td>63</td><td>67</td><td>76</td><td>76</td><td>74</td><td>68</td><td>87</td><td>83</td><td>86</td><td>86</td><td>73</td></tr><tr><td>Mouse 10</td><td>82</td><td>62</td><td>80</td><td>47</td><td>68</td><td>69</td><td>57</td><td>57</td><td>78</td><td>73</td><td>65</td><td>58</td><td></td><td>82</td><td>92</td><td>79</td><td>60</td><td>84</td><td>82</td><td>81</td><td>91</td><td>72</td></tr><tr><td>Mouse 11</td><td>70</td><td>60</td><td>87</td><td>69</td><td>65</td><td>71</td><td>73</td><td>65</td><td>70</td><td>68</td><td>72</td><td>54</td><td>64</td><td>80</td><td>76</td><td>73</td><td>63</td><td>87</td><td>87</td><td>84</td><td>90</td><td>73</td></tr><tr><td>Mouse 12</td><td>48</td><td>61</td><td>77</td><td>70</td><td>66</td><td>71</td><td>57</td><td>63</td><td>74</td><td>71</td><td>76</td><td>64</td><td>61</td><td>84</td><td>94</td><td>75</td><td>64</td><td>81</td><td>82</td><td>81</td><td>89</td><td>72</td></tr><tr><td>Mouse 13</td><td>79</td><td>64</td><td>81</td><td>73</td><td>64</td><td>69</td><td>66</td><td>67</td><td>69</td><td>68</td><td>75</td><td>62</td><td>64</td><td>80</td><td>81</td><td>72</td><td>66</td><td>LOD</td><td>77</td><td>84</td><td>86</td><td>72</td></tr><tr><td>Mouse 14</td><td>79</td><td>58</td><td>79</td><td>72</td><td>68</td><td>76</td><td>57</td><td>63</td><td>69</td><td>68</td><td>78</td><td>71</td><td></td><td>79</td><td>82</td><td>77</td><td>69</td><td>84</td><td>84</td><td>84</td><td>90</td><td>74</td></tr><tr><td>Mouse 15</td><td>74</td><td>55</td><td>80</td><td>75</td><td>68</td><td>74</td><td>71</td><td>60</td><td>72</td><td>66</td><td>71</td><td>60</td><td></td><td>81</td><td>80</td><td>71</td><td>64</td><td>83</td><td>84</td><td>85</td><td>89</td><td>73</td></tr><tr><td>Mouse 16</td><td>73</td><td>56</td><td>81</td><td>71</td><td>70</td><td>69</td><td>48</td><td>60</td><td>83</td><td>71</td><td>75</td><td>67</td><td>57</td><td>83</td><td>74</td><td>73</td><td>66</td><td>82</td><td>79</td><td>85</td><td>88</td><td>72</td></tr><tr><td>Mouse 17</td><td>76</td><td>59</td><td>71</td><td>78</td><td>62</td><td>78</td><td>72</td><td>66</td><td>66</td><td>67</td><td>68</td><td>65</td><td>65</td><td>78</td><td>LOD</td><td>77</td><td>65</td><td>82</td><td>79</td><td>83</td><td>91</td><td>72</td></tr><tr><td>mean</td><td>73</td><td>59</td><td>78</td><td>73</td><td>64</td><td>73</td><td>67</td><td>63</td><td>72</td><td>66</td><td>71</td><td>63</td><td>63</td><td>79</td><td>82</td><td>74</td><td>65</td><td>83</td><td>81</td><td>83</td><td>88</td><td>72</td></tr><tr><td>median</td><td>74</td><td>60</td><td>79</td><td>75</td><td>65</td><td>72</td><td>71</td><td>63</td><td>71</td><td>68</td><td>73</td><td>63</td><td>64</td><td>79</td><td>81</td><td>74</td><td>65</td><td>83</td><td>80</td><td>84</td><td>88</td><td>72</td></tr><tr><td>stdev</td><td>8</td><td>3</td><td>4</td><td>7</td><td>3</td><td>4</td><td>8</td><td>4</td><td>5</td><td>5</td><td>6</td><td>4</td><td>3</td><td>3</td><td>8</td><td>3</td><td>3</td><td>3</td><td>3</td><td>2</td><td>2</td><td>1</td></tr></table>
<table><tr><td></td><td colspan="7">Red clade</td><td colspan="7">Green clade</td><td colspan="7">Black clade</td><td></td></tr><tr><td></td><td>CabpIAP</td><td>IAP31</td><td>IAP44</td><td>IAP51</td><td>IAP77</td><td>IAP90</td><td>IAP110</td><td>IAP176</td><td>IAP182</td><td>IAP186</td><td>IAP195</td><td>IAP236</td><td>*IAP281Y</td><td>IAP268</td><td>IAP506</td><td>IAP655</td><td>IAP1112</td><td>IAP1248</td><td>IAP1252</td><td>IAP1259</td><td>IAP1334</td><td>Average</td></tr><tr><td>min</td><td>48</td><td>52</td><td>70</td><td>47</td><td>60</td><td>68</td><td>48</td><td>54</td><td>64</td><td>55</td><td>54</td><td>54</td><td>57</td><td>73</td><td>71</td><td>70</td><td>60</td><td>76</td><td>77</td><td>78</td><td>86</td><td>71</td></tr><tr><td>max</td><td>82</td><td>64</td><td>87</td><td>78</td><td>70</td><td>80</td><td>78</td><td>69</td><td>83</td><td>73</td><td>78</td><td>71</td><td>67</td><td>84</td><td>94</td><td>79</td><td>69</td><td>89</td><td>87</td><td>86</td><td>91</td><td>74</td></tr><tr><td>range</td><td>34</td><td>12</td><td>17</td><td>31</td><td>10</td><td>12</td><td>30</td><td>15</td><td>19</td><td>18</td><td>25</td><td>18</td><td>11</td><td>11</td><td>24</td><td>9</td><td>10</td><td>13</td><td>10</td><td>8</td><td>5</td><td>3</td></tr></table>
0cad36fe1c1bba851eaafc777e95686b15bbcf6ba00ac641ae2726478c3e1d14.png
simple
<table><tr><td>Algorithm</td><td>Average Error (&#176;)</td><td>Average Time (s)</td></tr><tr><td>Radon transform</td><td>0.17</td><td>8.61</td></tr><tr><td>MBR correction</td><td>0.16</td><td>1.13</td></tr></table>
<table><tr><td>Algorithm</td><td>Average Error (Β°)</td><td>Average Time (s)</td></tr><tr><td>Radon transform</td><td>0.17</td><td>8.61</td></tr></table>
<table><tr><td>Algorithm</td><td>Average Error (Β°)</td><td>Average Time (s)</td></tr><tr><td>MBR correction</td><td>0.16</td><td>1.13</td></tr></table>
66ebdb56b4f8e896dce2b1eaef16163fca67ac65d598d4918d9e1760cf8f84a6.png
simple
<table><tr><td></td><td>Normal range</td><td>Patient 1</td><td>Patient 2</td><td>Patient 3</td></tr><tr><td>Haemoglobin (g/L)</td><td>110&#8211;165</td><td>206</td><td>201</td><td></td></tr><tr><td>Total white cells (&#215;10<sup>9</sup> cells/L)</td><td>3 &#183; 5&#8211;10 &#183; 0</td><td>8 &#183; 9</td><td>58</td><td></td></tr><tr><td>Neutrophils (&#215;10<sup>9</sup> cells/L)</td><td>1 &#183; 2&#8211;6 &#183; 8</td><td>5 &#183; 79</td><td>41 &#183; 8</td><td></td></tr><tr><td>Lymphocytes (&#215;10<sup>9</sup> cells/L)</td><td>1 &#183; 2&#8211;3 &#183; 2</td><td>2 &#183; 76</td><td>10 &#183; 9</td><td></td></tr><tr><td>Platelets (&#215;10<sup>9</sup> cells/L)</td><td>150&#8211;390</td><td>18</td><td>162</td><td></td></tr><tr><td>Prothrombin time (s)</td><td>12&#8211;14</td><td>24 &#183; 8</td><td>15 &#183; 9</td><td></td></tr><tr><td>Activated partial thromboplastin time (s)</td><td>25&#8211;37</td><td>53 &#183; 1</td><td>67 &#183; 3</td><td></td></tr><tr><td>INR</td><td>0 &#183; 8&#8211;1 &#183; 5</td><td>2 &#183; 52</td><td>1 &#183; 43</td><td></td></tr><tr><td>D-dimer (mg/L)</td><td>&lt;0 &#183; 3</td><td>0 &#183; 2</td><td>0 &#183; 2</td><td></td></tr><tr><td>Urea (mmol/L)</td><td>2 &#183; 5&#8211;7 &#183; 5</td><td>7 &#183; 9</td><td>14 &#183; 8</td><td></td></tr><tr><td>Creatinine (&#956;mol/L)</td><td>44&#8211;135</td><td>161</td><td>253</td><td></td></tr><tr><td>Bilirubin (&#956;mol/L)</td><td>3 &#183; 42&#8211;20.5</td><td>17 &#183; 4</td><td>61 &#183; 8</td><td></td></tr><tr><td>Total protein (g/L)</td><td>60&#8211;80</td><td>30</td><td>60</td><td></td></tr><tr><td>Albumin (g/L)</td><td>35&#8211;50</td><td>23</td><td>35</td><td></td></tr><tr><td>Globulin (g/L)</td><td>25&#8211;35</td><td>7</td><td>25</td><td></td></tr><tr><td>Alanine aminotransferase (U/L)</td><td>0&#8211;40</td><td>35 &#183; 4</td><td>68</td><td></td></tr><tr><td>Aspartate aminotransferase (U/L)</td><td>0&#8211;37</td><td>67</td><td>479 &#183; 8</td><td></td></tr><tr><td>Lactate dehydrogenase (U/L)</td><td>109&#8211;245</td><td>127</td><td>585</td><td></td></tr><tr><td>Creatinine kinase (U/L)</td><td>24&#8211;195</td><td>146</td><td>9868</td><td></td></tr><tr><td>C-reactive protein (mg/L)</td><td>0&#8211;10</td><td>73</td><td>150</td><td></td></tr><tr><td>Glucose (mmol/L)</td><td>3 &#183; 9&#8211;6 &#183; 1</td><td>19</td><td>5 &#183; 1</td><td></td></tr><tr><td>Ka (mmol/L)</td><td>3 &#183; 5&#8211;5 &#183; 1</td><td>2 &#183; 6</td><td>3 &#183; 03</td><td></td></tr><tr><td>Na (mmol/L)</td><td>135&#8211;147</td><td>60</td><td>114</td><td></td></tr><tr><td>Cl (mmol/L)</td><td>95&#8211;106</td><td>40</td><td>80</td><td></td></tr><tr><td>Ca (mmol/L)</td><td>2 &#183; 25&#8211;2 &#183; 75</td><td>1 &#183; 62</td><td>2 &#183; 09</td><td></td></tr><tr><td>Urinalysis</td><td></td><td></td><td></td><td></td></tr><tr><td> PH value</td><td>5 &#183; 0&#8211;7 &#183; 0</td><td>5 &#183; 5</td><td>5 &#183; 0</td><td></td></tr><tr><td> Protein (mg/dl)</td><td></td><td>100</td><td>100</td><td></td></tr><tr><td> Ketone (mg/dl)</td><td></td><td>15</td><td>Neg</td><td></td></tr><tr><td> Bilirubin (mg/dl)</td><td></td><td>0 &#183; 5</td><td>0 &#183; 5</td><td></td></tr><tr><td> Urobilinogen (mg/dl)</td><td></td><td>8</td><td>4</td><td></td></tr><tr><td> Blood (mg/dl)</td><td></td><td>Neg</td><td>1</td><td></td></tr><tr><td> Leu (leu/ul)</td><td></td><td>75</td><td>Neg</td><td></td></tr><tr><td>Bacterial Diagnostic test</td><td></td><td></td><td></td><td></td></tr><tr><td> Microscopy</td><td>-</td><td>+</td><td>+</td><td>+</td></tr><tr><td> RT-PCR</td><td>-</td><td>+</td><td>+</td><td>+</td></tr><tr><td> IHA</td><td>-</td><td>1:40 (serum)</td><td>1:2560 (serum) 1:160 (tissue fluid)</td><td>1:800 (serum)</td></tr><tr><td> rIHA</td><td>-</td><td>1:6400 (nasopharyngeal swab) 1:12800 (sputum)</td><td>1:1024 (serum)</td><td>1:5120 (serum)</td></tr></table>
<table><tr><td></td><td>Normal range</td><td>Patient 1</td><td>Patient 2</td><td>Patient 3</td></tr><tr><td>Haemoglobin (g/L)</td><td>110–165</td><td>206</td><td>201</td><td></td></tr><tr><td>Total white cells (Γ—109 cells/L)</td><td>3 Β· 5–10 Β· 0</td><td>8 Β· 9</td><td>58</td><td></td></tr><tr><td>Neutrophils (Γ—109 cells/L)</td><td>1 Β· 2–6 Β· 8</td><td>5 Β· 79</td><td>41 Β· 8</td><td></td></tr><tr><td>Lymphocytes (Γ—109 cells/L)</td><td>1 Β· 2–3 Β· 2</td><td>2 Β· 76</td><td>10 Β· 9</td><td></td></tr><tr><td>Platelets (Γ—109 cells/L)</td><td>150–390</td><td>18</td><td>162</td><td></td></tr><tr><td>Prothrombin time (s)</td><td>12–14</td><td>24 Β· 8</td><td>15 Β· 9</td><td></td></tr><tr><td>Activated partial thromboplastin time (s)</td><td>25–37</td><td>53 Β· 1</td><td>67 Β· 3</td><td></td></tr><tr><td>INR</td><td>0 Β· 8–1 Β· 5</td><td>2 Β· 52</td><td>1 Β· 43</td><td></td></tr><tr><td>D-dimer (mg/L)</td><td><0 Β· 3</td><td>0 Β· 2</td><td>0 Β· 2</td><td></td></tr><tr><td>Urea (mmol/L)</td><td>2 Β· 5–7 Β· 5</td><td>7 Β· 9</td><td>14 Β· 8</td><td></td></tr><tr><td>Creatinine (ΞΌmol/L)</td><td>44–135</td><td>161</td><td>253</td><td></td></tr><tr><td>Bilirubin (ΞΌmol/L)</td><td>3 Β· 42–20.5</td><td>17 Β· 4</td><td>61 Β· 8</td><td></td></tr><tr><td>Total protein (g/L)</td><td>60–80</td><td>30</td><td>60</td><td></td></tr><tr><td>Albumin (g/L)</td><td>35–50</td><td>23</td><td>35</td><td></td></tr><tr><td>Globulin (g/L)</td><td>25–35</td><td>7</td><td>25</td><td></td></tr><tr><td>Alanine aminotransferase (U/L)</td><td>0–40</td><td>35 Β· 4</td><td>68</td><td></td></tr><tr><td>Aspartate aminotransferase (U/L)</td><td>0–37</td><td>67</td><td>479 Β· 8</td><td></td></tr><tr><td>Lactate dehydrogenase (U/L)</td><td>109–245</td><td>127</td><td>585</td><td></td></tr><tr><td>Creatinine kinase (U/L)</td><td>24–195</td><td>146</td><td>9868</td><td></td></tr><tr><td>C-reactive protein (mg/L)</td><td>0–10</td><td>73</td><td>150</td><td></td></tr><tr><td>Glucose (mmol/L)</td><td>3 Β· 9–6 Β· 1</td><td>19</td><td>5 Β· 1</td><td></td></tr><tr><td>Ka (mmol/L)</td><td>3 Β· 5–5 Β· 1</td><td>2 Β· 6</td><td>3 Β· 03</td><td></td></tr><tr><td>Na (mmol/L)</td><td>135–147</td><td>60</td><td>114</td><td></td></tr><tr><td>Cl (mmol/L)</td><td>95–106</td><td>40</td><td>80</td><td></td></tr><tr><td>Ca (mmol/L)</td><td>2 Β· 25–2 Β· 75</td><td>1 Β· 62</td><td>2 Β· 09</td><td></td></tr></table>
<table><tr><td>Urinalysis</td><td></td><td></td><td></td><td></td></tr><tr><td>PH value</td><td>5 Β· 0–7 Β· 0</td><td>5 Β· 5</td><td>5 Β· 0</td><td></td></tr><tr><td>Protein (mg/dl)</td><td></td><td>100</td><td>100</td><td></td></tr><tr><td>Ketone (mg/dl)</td><td></td><td>15</td><td>Neg</td><td></td></tr><tr><td>Bilirubin (mg/dl)</td><td></td><td>0 Β· 5</td><td>0 Β· 5</td><td></td></tr><tr><td>Urobilinogen (mg/dl)</td><td></td><td>8</td><td>4</td><td></td></tr><tr><td>Blood (mg/dl)</td><td></td><td>Neg</td><td>1</td><td></td></tr><tr><td>Leu (leu/ul)</td><td></td><td>75</td><td>Neg</td><td></td></tr><tr><td>Bacterial Diagnostic test</td><td></td><td></td><td></td><td></td></tr><tr><td>Microscopy</td><td>-</td><td>+</td><td>+</td><td>+</td></tr><tr><td>RT-PCR</td><td>-</td><td>+</td><td>+</td><td>+</td></tr><tr><td>IHA</td><td>-</td><td>1:40 (serum)</td><td>1:2560 (serum) 1:160 (tissue fluid)</td><td>1:800 (serum)</td></tr><tr><td>rIHA</td><td>-</td><td>1:6400 (nasopharyngeal swab) 1:12800 (sputum)</td><td>1:1024 (serum)</td><td>1:5120 (serum)</td></tr></table>
86c4f3d64716b749c9f1740386504895476c307949448d624aaba8db71b59662.png
simple
<table><tr><td></td><td>2009</td><td>2010</td><td>2011</td><td>2012</td><td>2013</td></tr><tr><td>Percent (+) of all tests run</td><td>12.22%</td><td>15.45%</td><td>12.30%</td><td>13.70%</td><td>13.70%</td></tr><tr><td>NEW (+) as % of all tests run</td><td>5.90%</td><td>7.86%</td><td>5.60%</td><td>7.01%</td><td>6.10%</td></tr><tr><td>Profile of a NEW (+) out of ALL new (+)&#8217;s</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Incomplete-vaccination</td><td>86.59% (71/82)</td><td>89.52% (94/105)</td><td>85.92% (61/71)</td><td>86.08% (68/79)</td><td>95.45% (63/66)</td></tr><tr><td>Full-vaccination</td><td>13.41% (11/82)</td><td>10.48% (11/105)</td><td>14.08% (10/71)</td><td>13.92% (11/79)</td><td>4.55% (3/66)</td></tr><tr><td>Infection rate (IR) based on vaccine status*:</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>ALL incomplete-vaccination</td><td>16.86% (71/421)</td><td>32.08% (94/293)</td><td>18.32% (61/333)</td><td>23.13% (68/294)</td><td>20.32% (63/310)</td></tr><tr><td>Complete-vaccination</td><td>1.13% (11/970)</td><td>1.04% (11/1053)</td><td>1.07% (10/933)</td><td>1.32% (11/833)</td><td>0.39% (3/762)</td></tr><tr><td>Negative infection rate based on vaccine status</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>ALL incomplete-vaccination</td><td>83.14% (350/421)</td><td>67.92% (199/293)</td><td>81.68% (272/333)</td><td>76.87% (226/294)</td><td>79.68% (247/310)</td></tr><tr><td>Complete-vaccination</td><td>98.87% (959/970)</td><td>98.96% (1042/1053)</td><td>98.93% (923/933)</td><td>98.68% (822/833)</td><td>99.61% (759/762)</td></tr><tr><td>Chi-square test statistic</td><td>130.95</td><td>307.01</td><td>137.89</td><td>158.56</td><td>151.47</td></tr><tr><td>P-value</td><td>&lt;0.0001</td><td>&lt;0.0001</td><td>&lt;0.0001</td><td>&lt;0.0001</td><td>&lt;0.0001</td></tr><tr><td>Preventative fraction (PF) against infection**</td><td>93.29%</td><td>96.76%</td><td>94.16%</td><td>94.29%</td><td>98.08%</td></tr><tr><td>Risk ratio (RR)***</td><td>14.92</td><td>30.85</td><td>17.12</td><td>17.52</td><td>52.10</td></tr></table>
<table><tr><td></td><td>2009</td><td>2010</td><td>2011</td><td>2012</td><td>2013</td></tr></table>
<table><tr><td>Percent (+) of all tests run</td><td>12.22%</td><td>15.45%</td><td>12.30%</td><td>13.70%</td><td>13.70%</td></tr><tr><td>NEW (+) as % of all tests run</td><td>5.90%</td><td>7.86%</td><td>5.60%</td><td>7.01%</td><td>6.10%</td></tr><tr><td>Profile of a NEW (+) out of ALL new (+)’s</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Incomplete-vaccination</td><td>86.59% (71/82)</td><td>89.52% (94/105)</td><td>85.92% (61/71)</td><td>86.08% (68/79)</td><td>95.45% (63/66)</td></tr><tr><td>Full-vaccination</td><td>13.41% (11/82)</td><td>10.48% (11/105)</td><td>14.08% (10/71)</td><td>13.92% (11/79)</td><td>4.55% (3/66)</td></tr><tr><td>Infection rate (IR) based on vaccine status*:</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>ALL incomplete-vaccination</td><td>16.86% (71/421)</td><td>32.08% (94/293)</td><td>18.32% (61/333)</td><td>23.13% (68/294)</td><td>20.32% (63/310)</td></tr><tr><td>Complete-vaccination</td><td>1.13% (11/970)</td><td>1.04% (11/1053)</td><td>1.07% (10/933)</td><td>1.32% (11/833)</td><td>0.39% (3/762)</td></tr><tr><td>Negative infection rate based on vaccine status</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>ALL incomplete-vaccination</td><td>83.14% (350/421)</td><td>67.92% (199/293)</td><td>81.68% (272/333)</td><td>76.87% (226/294)</td><td>79.68% (247/310)</td></tr><tr><td>Complete-vaccination</td><td>98.87% (959/970)</td><td>98.96% (1042/1053)</td><td>98.93% (923/933)</td><td>98.68% (822/833)</td><td>99.61% (759/762)</td></tr><tr><td>Chi-square test statistic</td><td>130.95</td><td>307.01</td><td>137.89</td><td>158.56</td><td>151.47</td></tr><tr><td>P-value</td><td><0.0001</td><td><0.0001</td><td><0.0001</td><td><0.0001</td><td><0.0001</td></tr><tr><td>Preventative fraction (PF) against infection**</td><td>93.29%</td><td>96.76%</td><td>94.16%</td><td>94.29%</td><td>98.08%</td></tr><tr><td>Risk ratio (RR)***</td><td>14.92</td><td>30.85</td><td>17.12</td><td>17.52</td><td>52.10</td></tr></table>
1f31943bfc014919c02c50f0842b9f197b3f989f9a897b3582b101b8ae1ddec5.png
simple
<table><tr><td>Compound number</td><td>Alkyl substitute</td><td>MIC <i>M. tuberculosis</i> (ng/ml)</td><td>log<i>P</i>*</td></tr><tr><td>10926013</td><td>Methyl</td><td>250</td><td>1.31</td></tr><tr><td>10926021</td><td>Ethyl</td><td>62</td><td>1.64</td></tr><tr><td>10926027</td><td>Propyl</td><td>3.7</td><td>2.11</td></tr><tr><td>10926172</td><td>Butyl</td><td>1.9</td><td>2.51</td></tr><tr><td>11026100</td><td>Isobutyl</td><td>1.9</td><td>2.51</td></tr><tr><td>11026142</td><td>1-Ethylpropyl</td><td>0.37</td><td>2.99</td></tr><tr><td>11026128</td><td>1-<i>sec</i>-Butyl</td><td>0.37</td><td>2.52</td></tr><tr><td>11026129, PBTZ129</td><td>2-Cyclohexylethyl</td><td>0.19</td><td>3.52</td></tr><tr><td>11026131</td><td>1-Methylbutyl</td><td>0.19</td><td>3.11</td></tr><tr><td>11026134, PBTZ134</td><td>Heptyl</td><td>0.19</td><td>3.30</td></tr><tr><td>11026137, PBTZ137</td><td>4-Phenoxybutyl</td><td>1.5</td><td>3.35</td></tr><tr><td>11026139, PBTZ139</td><td>4-Phenylbutyl</td><td>0.37</td><td>4.05</td></tr><tr><td>10926168</td><td>Cyclohexyl</td><td>0.75</td><td>3.09</td></tr><tr><td>10926169, PBTZ169</td><td>Cyclohexylmethyl</td><td>&#8804;0.19</td><td>3.20</td></tr></table>
<table><tr><td>Compound number</td><td>Alkyl substitute</td><td>MIC M. tuberculosis (ng/ml)</td><td>logP*</td></tr><tr><td>10926013</td><td>Methyl</td><td>250</td><td>1.31</td></tr><tr><td>10926021</td><td>Ethyl</td><td>62</td><td>1.64</td></tr><tr><td>10926027</td><td>Propyl</td><td>3.7</td><td>2.11</td></tr><tr><td>10926172</td><td>Butyl</td><td>1.9</td><td>2.51</td></tr><tr><td>11026100</td><td>Isobutyl</td><td>1.9</td><td>2.51</td></tr><tr><td>11026142</td><td>1-Ethylpropyl</td><td>0.37</td><td>2.99</td></tr><tr><td>11026128</td><td>1-sec-Butyl</td><td>0.37</td><td>2.52</td></tr><tr><td>11026129, PBTZ129</td><td>2-Cyclohexylethyl</td><td>0.19</td><td>3.52</td></tr><tr><td>11026131</td><td>1-Methylbutyl</td><td>0.19</td><td>3.11</td></tr><tr><td>11026134, PBTZ134</td><td>Heptyl</td><td>0.19</td><td>3.30</td></tr><tr><td>11026137, PBTZ137</td><td>4-Phenoxybutyl</td><td>1.5</td><td>3.35</td></tr><tr><td>11026139, PBTZ139</td><td>4-Phenylbutyl</td><td>0.37</td><td>4.05</td></tr></table>
<table><tr><td>Compound number</td><td>Alkyl substitute</td><td>MIC M. tuberculosis (ng/ml)</td><td>logP*</td></tr><tr><td>10926168</td><td>Cyclohexyl</td><td>0.75</td><td>3.09</td></tr><tr><td>10926169, PBTZ169</td><td>Cyclohexylmethyl</td><td>≀0.19</td><td>3.20</td></tr></table>
76ff143d8c9a1d1d7a0e92932657c17d58bf815f95ede0ada7a4ab0de8e7fac9.png
simple
<table><tr><td>Score</td><td>Reactions</td></tr><tr><td>&#8722;</td><td>Negative reaction</td></tr><tr><td>+?</td><td>Doubtful reaction; faint erythema only</td></tr><tr><td>+</td><td>Weak (non-vesicular) positive reaction; erythema, infiltration and possibly papules</td></tr><tr><td>++</td><td>Strong (vesicular) positive reaction; erythema, infiltration, papules, vesicles</td></tr><tr><td>+++</td><td>Extreme positive reaction; bullous reaction</td></tr><tr><td>IR</td><td>Irritant reaction</td></tr></table>
<table><tr><td>Score</td><td>Reactions</td></tr><tr><td>βˆ’</td><td>Negative reaction</td></tr><tr><td>+?</td><td>Doubtful reaction; faint erythema only</td></tr><tr><td>+</td><td>Weak (non-vesicular) positive reaction; erythema, infiltration and possibly papules</td></tr><tr><td>++</td><td>Strong (vesicular) positive reaction; erythema, infiltration, papules, vesicles</td></tr></table>
<table><tr><td>Score</td><td>Reactions</td></tr><tr><td>+++</td><td>Extreme positive reaction; bullous reaction</td></tr><tr><td>IR</td><td>Irritant reaction</td></tr></table>
ea14cfca3869669b28da700fb991f1f897b4aab75ef86092c95ba20f53a91f73.png
simple
<table><tr><td>Eligible</td><td>Ineligible</td></tr><tr><td>Sexually active</td><td>Unable or unwilling to provide a reliable method of contact for the field team</td></tr><tr><td>16 years old or above</td><td>Likely to move permanently out of the study area within the next year</td></tr><tr><td>HIV negative at screening</td><td>Likely to have sex more than 14 times a week on a regular basis during the course of following up</td></tr><tr><td>Willing to undergo regular HIV testing and receive the result before randomization</td><td>Using spermicides regularly</td></tr><tr><td>Willing to undergo regular speculum examinations and genital infection screens</td><td>Pregnant or within six weeks postpartum at enrolment</td></tr><tr><td>Willing to have regular urine pregnancy tests</td><td>Had a severe clinical or laboratory abnormality</td></tr><tr><td>Willing to use study gel as instructed</td><td>Requiring referral for assessment of a clinically suspicious cervical lesion</td></tr><tr><td>Willing to receive health education about condoms</td><td>Had treatment to the cervix, or to the womb through the cervix, within 30 days of enrolment</td></tr><tr><td>Willing and able to give informed consent</td><td>Had known latex allergy</td></tr><tr><td> </td><td>Participating, or having participated within 30 days of enrolment, in a clinical trial of an unlicensed product, microbicide, barrier method or any other intervention likely to impact on the outcome of this trial</td></tr><tr><td> </td><td>Considered unlikely to be able to comply with the protocol</td></tr></table>
<table><tr><td>Eligible</td><td>Ineligible</td></tr><tr><td>Sexually active</td><td>Unable or unwilling to provide a reliable method of contact for the field team</td></tr><tr><td>16 years old or above</td><td>Likely to move permanently out of the study area within the next year</td></tr><tr><td>HIV negative at screening</td><td>Likely to have sex more than 14 times a week on a regular basis during the course of following up</td></tr><tr><td>Willing to undergo regular HIV testing and receive the result before randomization</td><td>Using spermicides regularly</td></tr><tr><td>Willing to undergo regular speculum examinations and genital infection screens</td><td>Pregnant or within six weeks postpartum at enrolment</td></tr></table>
<table><tr><td>Eligible</td><td>Ineligible</td></tr><tr><td>Willing to have regular urine pregnancy tests</td><td>Had a severe clinical or laboratory abnormality</td></tr><tr><td>Willing to use study gel as instructed</td><td>Requiring referral for assessment of a clinically suspicious cervical lesion</td></tr><tr><td>Willing to receive health education about condoms</td><td>Had treatment to the cervix, or to the womb through the cervix, within 30 days of enrolment</td></tr><tr><td>Willing and able to give informed consent</td><td>Had known latex allergy</td></tr><tr><td></td><td>Participating, or having participated within 30 days of enrolment, in a clinical trial of an unlicensed product, microbicide, barrier method or any other intervention likely to impact on the outcome of this trial</td></tr><tr><td></td><td>Considered unlikely to be able to comply with the protocol</td></tr></table>
c7d177ce5f7c61ce2d86fc8d46e56ef8ae931a6ad1b161f6e6247b3fac935dd8.png
simple
<table><tr><td>Malaria is caused by:</td><td>Total (N = 34)</td></tr><tr><td>Self<sup>1</sup></td><td></td></tr><tr><td>Mentioned mosquitoes as cause</td><td>33 (97.1%)</td></tr><tr><td>Mentioned environmental cause<sup>2</sup></td><td>9 (26.5%)</td></tr><tr><td>Mentioned bad food/water consumption as cause</td><td>8 (23.5%)</td></tr><tr><td>Mentioned cold temperatures/rain as cause</td><td>13 (38.2%)</td></tr><tr><td>Mentioned mosquitoes solely as cause</td><td>15 (44.1%)</td></tr><tr><td>Mentioned mosquitoes plus additional cause</td><td>18 (52.9%)</td></tr><tr><td>Mentioned both an accurate and an inaccurate cause</td><td>16 (47.1%)</td></tr><tr><td>Others</td><td></td></tr><tr><td>Mentioned mosquitoes as cause</td><td>20 (58.8%)</td></tr><tr><td>Mentioned environmental cause</td><td>5 (14.7%)</td></tr><tr><td>Mentioned bad food/water consumption as cause</td><td>6 (17.6%)</td></tr><tr><td>Mentioned cold temperatures/rain as cause</td><td>6 (17.6%)</td></tr><tr><td>Mentioned mosquitoes solely as cause</td><td>14 (41.2%)</td></tr><tr><td>Mentioned mosquitoes plus additional cause</td><td>6 (17.6%)</td></tr><tr><td>Did not mention moquitoes; mentioned other cause</td><td>9 (26.5%)</td></tr><tr><td>Did not know cause</td><td>5 (14.7%)</td></tr></table>
<table><tr><td>Malaria is caused by:</td><td>Total (N = 34)</td></tr><tr><td>Self1</td><td></td></tr><tr><td>Mentioned mosquitoes as cause</td><td>33 (97.1%)</td></tr><tr><td>Mentioned environmental cause2</td><td>9 (26.5%)</td></tr><tr><td>Mentioned bad food/water consumption as cause</td><td>8 (23.5%)</td></tr><tr><td>Mentioned cold temperatures/rain as cause</td><td>13 (38.2%)</td></tr><tr><td>Mentioned mo</td><td>15 (4</td></tr></table>
<table><tr><td>Malaria is caused by:</td><td>Total (N = 34)</td></tr><tr><td>squitoes solely as cause</td><td>4.1%)</td></tr><tr><td>Mentioned mosquitoes plus additional cause</td><td>18 (52.9%)</td></tr><tr><td>Mentioned both an accurate and an inaccurate cause</td><td>16 (47.1%)</td></tr><tr><td>Others</td><td></td></tr><tr><td>Mentioned mosquitoes as cause</td><td>20 (58.8%)</td></tr><tr><td>Mentioned environmental cause</td><td>5 (14.7%)</td></tr><tr><td>Mentioned bad food/water consumption as cause</td><td>6 (17.6%)</td></tr><tr><td>Mentioned cold temperatures/rain as cause</td><td>6 (17.6%)</td></tr><tr><td>Mentioned mosquitoes solely as cause</td><td>14 (41.2%)</td></tr><tr><td>Mentioned mosquitoes plus additional cause</td><td>6 (17.6%)</td></tr><tr><td>Did not mention moquitoes; mentioned other cause</td><td>9 (26.5%)</td></tr><tr><td>Did not know cause</td><td>5 (14.7%)</td></tr></table>
a7515f6bd3ddb05697c8aca691736b61a080693dcdcec2dbc5ae1b52611c01b1.png
simple
<table><tr><td>Antibody</td><td>Type</td><td>Dilution</td><td>Source</td></tr><tr><td>Cytokeratin 7</td><td>Rabbit-Monoclonal</td><td>1:100</td><td>Biocare Medical, Concord, CA</td></tr><tr><td>Cytokeratin 20</td><td>Mouse Monoclonal</td><td>1:200</td><td>Biocare Medical, Concord, CA</td></tr><tr><td>CDX-2</td><td>Mouse Monoclonal</td><td>1:100</td><td>Biocare Medical, Concord, CA</td></tr><tr><td>Villin</td><td>Mouse Monoclonal</td><td>1:100</td><td>Biocare Medical, Concord, CA</td></tr><tr><td>&#946;-catenin</td><td>Mouse Monoclonal</td><td>1:200</td><td>DAKO, Carpinteria, CA</td></tr><tr><td>E-cadherin</td><td>Mouse Monoclonal</td><td>1:2000</td><td>BD Transduction Labs, San Jose, CA</td></tr></table>
<table><tr><td>Antibody</td><td>Type</td><td>Dilution</td><td>Source</td></tr><tr><td>Cytokeratin 7</td><td>Rabbit-Monoclonal</td><td>1:100</td><td>Biocare Medical, Concord, CA</td></tr><tr><td>Cytokeratin 20</td><td>Mouse Monoclonal</td><td>1:200</td><td>Biocare Medical, Concord, CA</td></tr><tr><td>CDX-2</td><td>Mouse Monoclonal</td><td>1:100</td><td>Biocare Medical, Concord, CA</td></tr><tr><td>Vi</td><td>Mouse Monoclo</td><td></td><td>Bioc</td></tr></table>
<table><tr><td>llin</td><td>nal</td><td>1:100</td><td>are Medical, Concord, CA</td></tr><tr><td>Ξ²-catenin</td><td>Mouse Monoclonal</td><td>1:200</td><td>DAKO, Carpinteria, CA</td></tr><tr><td>E-cadherin</td><td>Mouse Monoclonal</td><td>1:2000</td><td>BD Transduction Labs, San Jose, CA</td></tr></table>
fb7e9bcdda5102d5b58b8378416598d62cdb00a948080d9e4a27e79909b08a18.png
simple
<table><tr><td>Name</td><td>5<sup>&#8242;</sup> -3<sup>&#8242;</sup></td><td>Length</td></tr><tr><td>PrimerF1</td><td>AGTATCGTTGAGAAGAATCG</td><td>20</td></tr><tr><td>PrimerF2</td><td>TATGCTTTCCTGGCGGCGGTAC</td><td>22</td></tr><tr><td>PrimerF3</td><td>GAAGGGGAGACAAGCAGATCAA</td><td>22</td></tr><tr><td>PrimerF4</td><td>CTGCAAGAGAGGAAAAAGACCA</td><td>22</td></tr><tr><td>PrimerF5</td><td>GGAGGGGCAGAGTAGGCAGAAA</td><td>22</td></tr><tr><td>PrimerF6</td><td>CCGTTGGCTCGTGGAGAAAGGA</td><td>22</td></tr><tr><td>PrimerF7</td><td>TCAGCGGAGATGACTGTGTCGT</td><td>22</td></tr><tr><td>PrimerR1</td><td>CCTTCATTTCCTCCTCTTTTGT</td><td>22</td></tr><tr><td>PrimerR2</td><td>TGAACGGCTTTTCCTATGGAGT</td><td>22</td></tr><tr><td>PrimerR3</td><td>CAAACATCAATCCAACTGCCGA</td><td>22</td></tr><tr><td>PrimerR4</td><td>AGTCCATTGGGCATGTGTATGT</td><td>22</td></tr><tr><td>PrimerR5</td><td>TCTGCATGAGCATCGGTTCTTC</td><td>22</td></tr><tr><td>PrimerR6</td><td>AAATGGTTAGAGCAGAAGGGAA</td><td>22</td></tr><tr><td>PrimerR7</td><td>TCTTCCTCACCACCAGCTACAT</td><td>22</td></tr></table>
<table><tr><td>Name</td><td>5β€² -3β€²</td><td>Length</td></tr><tr><td>PrimerF1</td><td>AGTATCGTTGAGAAGAATCG</td><td>20</td></tr><tr><td>PrimerF2</td><td>TATGCTTTCCTGGCGGCGGTAC</td><td>22</td></tr><tr><td>PrimerF3</td><td>GAAGGGGAGACAAGCAGATCAA</td><td>22</td></tr><tr><td>PrimerF4</td><td>CTGCAAGAGAGGAAAAAGACCA</td><td>22</td></tr><tr><td>PrimerF5</td><td>GGAGGGGCAGAGTAGGCAGAAA</td><td>22</td></tr><tr><td>PrimerF6</td><td>CCGTTGGCTCGTGGAGAAAGGA</td><td>22</td></tr></table>
<table><tr><td>Name</td><td>5β€² -3β€²</td><td>Length</td></tr><tr><td>PrimerF7</td><td>TCAGCGGAGATGACTGTGTCGT</td><td>22</td></tr><tr><td>PrimerR1</td><td>CCTTCATTTCCTCCTCTTTTGT</td><td>22</td></tr><tr><td>PrimerR2</td><td>TGAACGGCTTTTCCTATGGAGT</td><td>22</td></tr><tr><td>PrimerR3</td><td>CAAACATCAATCCAACTGCCGA</td><td>22</td></tr><tr><td>PrimerR4</td><td>AGTCCATTGGGCATGTGTATGT</td><td>22</td></tr><tr><td>PrimerR5</td><td>TCTGCATGAGCATCGGTTCTTC</td><td>22</td></tr><tr><td>PrimerR6</td><td>AAATGGTTAGAGCAGAAGGGAA</td><td>22</td></tr><tr><td>PrimerR7</td><td>TCTTCCTCACCACCAGCTACAT</td><td>22</td></tr></table>
168a527c7630e5a3e0dcf29d6e83c9c1e624569ef5d40c3f66201ae1b7a24c6e.png
complex
<table><tr><td> </td><td colspan="2">Controls</td><td colspan="2">Cases</td><td> </td><td> </td><td colspan="2"> </td></tr><tr><td>Medications</td><td>%</td><td>(n)</td><td>%</td><td>(n)</td><td>Crude OR (95% CI)</td><td>ORs (95% CI) adjusted for age and sex</td><td>ORs (95% CI) adjusted for age, sex and other risk factors*</td><td>ORs (95%CI) adjusted for age, sex, other risk factors* and the use of FRIDs</td></tr><tr><td>All medications</td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td> <i>0 medication</i></td><td>40.7</td><td>(8318)</td><td>28.3</td><td>(130)</td><td>1.00</td><td>(REF)</td><td>1.00 (Ref)</td><td>1.00 (Ref)</td></tr><tr><td> <i>1 medication</i></td><td>12.0</td><td>(2443)</td><td>7.4</td><td>(34)</td><td>0.91 (0.60-1.38)</td><td>0.95 (0.63-1.45)</td><td>1.26 (0.75-2.11)</td><td>1.40 (0.82-2.40)</td></tr><tr><td> <i>2 medications</i></td><td>11.2</td><td>(2283)</td><td>11.7</td><td>(54)</td><td>1.63 (1.14-2.32)</td><td>1.44 (1.01-2.05)</td><td>1.74 (1.10-2.77)</td><td>2.06 (1.16-3.64)</td></tr><tr><td> <i>3 medications</i></td><td>9.8</td><td>(1998)</td><td>9.6</td><td>(44)</td><td>1.58 (1.09-2.31)</td><td>1.34 (0.91-1.95)</td><td>1.50 (0.94-2.41)</td><td>1.83 (0.94-3.57)</td></tr><tr><td> <i>4 medications</i></td><td>8.0</td><td>(1636)</td><td>9.8</td><td>(45)</td><td>1.82 (1.24-2.68)</td><td>1.45 (0.98-2.16)</td><td>1.74 (1.07-2.81)</td><td>2.14 (1.13-4.05)</td></tr><tr><td> <i>&#8805;5 medications</i></td><td>18.4</td><td>(3768)</td><td>33.3</td><td>(153)</td><td>2.58 (1.98-3.36)</td><td>1.79 (1.36-2.35)</td><td>1.53 (1.06-2.21)</td><td>1.92 (1.08-3.41)</td></tr></table>
<table><tr><td></td><td colspan="2">Controls</td><td colspan="2">Cases</td><td></td><td></td><td colspan="2"></td></tr><tr><td>Medications</td><td>%</td><td>(n)</td><td>%</td><td>(n)</td><td>Crude OR (95% CI)</td><td>ORs (95% CI) adjusted for age and sex</td><td>ORs (95% CI) adjusted for age, sex and other risk factors*</td><td>ORs (95%CI) adjusted for age, sex, other risk factors* and the use of FRIDs</td></tr><tr><td>All medications</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>0 medication</td><td>40.7</td><td>(8318)</td><td>28.3</td><td>(130)</td><td>1.00</td><td>(REF)</td><td>1.00 (Ref)</td><td>1.00 (Ref)</td></tr><tr><td>1</td><td></td><td>(2443</td><td>7.4</td><td>(34</td><td>0.</td><td>0.95 (0.63-1.4</td><td>1.26 (0.75-2.11</td><td>1.40 (0.82-2.40</td></tr></table>
<table><tr><td> medication</td><td>12.0</td><td>)</td><td></td><td>)</td><td>91 (0.60-1.38)</td><td>5)</td><td>)</td><td>)</td></tr><tr><td>2 medications</td><td>11.2</td><td>(2283)</td><td>11.7</td><td>(54)</td><td>1.63 (1.14-2.32)</td><td>1.44 (1.01-2.05)</td><td>1.74 (1.10-2.77)</td><td>2.06 (1.16-3.64)</td></tr><tr><td>3 medications</td><td>9.8</td><td>(1998)</td><td>9.6</td><td>(44)</td><td>1.58 (1.09-2.31)</td><td>1.34 (0.91-1.95)</td><td>1.50 (0.94-2.41)</td><td>1.83 (0.94-3.57)</td></tr><tr><td>4 medications</td><td>8.0</td><td>(1636)</td><td>9.8</td><td>(45)</td><td>1.82 (1.24-2.68)</td><td>1.45 (0.98-2.16)</td><td>1.74 (1.07-2.81)</td><td>2.14 (1.13-4.05)</td></tr><tr><td>β‰₯5 medications</td><td>18.4</td><td>(3768)</td><td>33.3</td><td>(153)</td><td>2.58 (1.98-3.36)</td><td>1.79 (1.36-2.35)</td><td>1.53 (1.06-2.21)</td><td>1.92 (1.08-3.41)</td></tr></table>
ccfd7146a7a2acb884f11ecd49a6611ccda06767c1fce056e59ffd41597e53ec.png
simple
<table><tr><td>Variable</td><td>Mean (SD)</td><td>N</td><td>%</td></tr><tr><td>Age</td><td>37.2 (6.1)</td><td></td><td></td></tr><tr><td>Marital status</td><td></td><td></td><td></td></tr><tr><td> Married</td><td></td><td>231</td><td>96.3</td></tr><tr><td> Widowed/Divorced</td><td></td><td>9</td><td>3.8</td></tr><tr><td>Education</td><td></td><td></td><td></td></tr><tr><td> Primary</td><td></td><td>70</td><td>29.2</td></tr><tr><td> Secondary</td><td></td><td>52</td><td>21.6</td></tr><tr><td> High school</td><td></td><td>78</td><td>32.5</td></tr><tr><td> University</td><td></td><td>40</td><td>16.7</td></tr><tr><td>History of breast problems</td><td></td><td></td><td></td></tr><tr><td> Yes</td><td></td><td>29</td><td>12.1</td></tr><tr><td> No</td><td></td><td>211</td><td>87.9</td></tr><tr><td>Performing BSE</td><td></td><td></td><td></td></tr><tr><td> Yes (regular* &amp; irregular**)</td><td></td><td>76</td><td>31.7</td></tr><tr><td> No (never done)</td><td></td><td>164</td><td>68.3</td></tr></table>
<table><tr><td>Variable</td></tr><tr><td>Age</td></tr><tr><td>Marital status</td></tr><tr><td>Married</td></tr><tr><td>Widowed/Divorced</td></tr><tr><td>Education</td></tr><tr><td>Primary</td></tr><tr><td>Secondary</td></tr><tr><td>High school</td></tr><tr><td>University</td></tr><tr><td>History of breast problems</td></tr><tr><td>Yes</td></tr><tr><td>No</td></tr><tr><td>Performing BSE</td></tr><tr><td>Yes (regular* & irregular**)</td></tr><tr><td>No (never done)</td></tr></table>
<table><tr><td>Mean (SD)</td><td>N</td><td>%</td></tr><tr><td>37.2 (6.1)</td><td></td><td></td></tr><tr><td></td><td></td><td></td></tr><tr><td></td><td>231</td><td>96.3</td></tr><tr><td></td><td>9</td><td>3.8</td></tr><tr><td></td><td></td><td></td></tr><tr><td></td><td>70</td><td>29.2</td></tr><tr><td></td><td>52</td><td>21.6</td></tr><tr><td></td><td>78</td><td>32.5</td></tr><tr><td></td><td>40</td><td>16.7</td></tr><tr><td></td><td></td><td></td></tr><tr><td></td><td>29</td><td>12.1</td></tr><tr><td></td><td>211</td><td>87.9</td></tr><tr><td></td><td></td><td></td></tr><tr><td></td><td>76</td><td>31.7</td></tr><tr><td></td><td>164</td><td>68.3</td></tr></table>
61188b5d79a751602e6ff7d41f76be4ded667310a3861c8ae0180ae8d59e219e.png
complex
<table><tr><td rowspan="2">Characteristics</td><td colspan="3">Univariate analysis</td><td colspan="3">Multivariate analysis</td></tr><tr><td></td><td>HR (95% CI)</td><td><i>P</i>-value*</td><td>HR (95% CI)</td><td><i>P</i>-value*</td></tr><tr><td colspan="5">HBP1 IHC</td></tr><tr><td> Absent/decreased</td><td>1.00</td><td></td><td>1.00</td><td></td></tr><tr><td> Preserved</td><td>0.48 (0.24&#8211;0.96)</td><td>0.039</td><td>0.38 (0.15&#8211;0.96)</td><td>0.042</td></tr><tr><td colspan="5">&#946;-catenin nuclear accumulation</td></tr><tr><td> Yes</td><td>1.00</td><td></td><td>1.00</td><td></td></tr><tr><td> No</td><td>0.49 (0.24&#8211;0.99)</td><td>0.047</td><td>0.38 (0.15&#8211;0.96)</td><td>0.041</td></tr><tr><td colspan="5">Smoking habit</td></tr><tr><td> Non-smoker</td><td>1.00</td><td></td><td>1.00</td><td></td></tr><tr><td> Smoker</td><td>0.66 (0.28&#8211;1.57)</td><td>0.348</td><td>0.58 (0.20&#8211;1.72)</td><td>0.326</td></tr><tr><td colspan="5">Tumour type</td></tr><tr><td> ADC</td><td>1.00</td><td></td><td>1.00</td><td></td></tr><tr><td> SCC</td><td>1.01 (0.73&#8211;2.17)</td><td>0.973</td><td>1.17 (0.38&#8211;3.67)</td><td>0.784</td></tr><tr><td colspan="5">Tumour stage</td></tr><tr><td> Early (I/II)</td><td>1.00</td><td></td><td>1.00</td><td></td></tr><tr><td> Late (III/IV)</td><td>1.58 (0.77&#8211;3.26)</td><td>0.213</td><td>0.68 (0.21&#8211;2.26)</td><td>0.532</td></tr><tr><td colspan="5">Lymph node status</td></tr><tr><td> N0</td><td>1.00</td><td></td><td>1.00</td><td></td></tr><tr><td> &#8805;N1</td><td>2.01 (0.99&#8211;4.10)</td><td>0.055</td><td>3.34 (1.02&#8211;10.92)</td><td>0.046</td></tr></table>
<table><tr><td rowspan="2">Characteristics</td><td colspan="3">Univariate analysis</td></tr><tr><td></td><td>HR (95% CI)</td><td>P-value*</td></tr><tr><td colspan="4">HBP1 IHC</td></tr><tr><td>Absent/decreased</td><td>1.00</td><td></td><td>1.00</td></tr><tr><td>Preserved</td><td>0.48 (0.24–0.96)</td><td>0.039</td><td>0.38 (0.15–0.96)</td></tr><tr><td colspan="4">Ξ²-catenin nuclear accumulation</td></tr><tr><td>Yes</td><td>1.00</td><td></td><td>1.00</td></tr><tr><td>No</td><td>0.49 (0.24–0.99)</td><td>0.047</td><td>0.38 (0.15–0.96)</td></tr><tr><td colspan="4">Smoking habit</td></tr><tr><td>Non-smoker</td><td>1.00</td><td></td><td>1.00</td></tr><tr><td>Smoker</td><td>0.66 (0.28–1.57)</td><td>0.348</td><td>0.58 (0.20–1.72)</td></tr><tr><td colspan="4">Tumour type</td></tr><tr><td>ADC</td><td>1.00</td><td></td><td>1.00</td></tr><tr><td>SCC</td><td>1.01 (0.73–2.17)</td><td>0.973</td><td>1.17 (0.38–3.67)</td></tr><tr><td colspan="4">Tumour stage</td></tr><tr><td>Early (I/II)</td><td>1.00</td><td></td><td>1.00</td></tr><tr><td>Late (III/IV)</td><td>1.58 (0.77–3.26)</td><td>0.213</td><td>0.68 (0.21–2.26)</td></tr><tr><td colspan="4">Lymph node status</td></tr><tr><td>N0</td><td>1.00</td><td></td><td>1.00</td></tr><tr><td>β‰₯N1</td><td>2.01 (0.99–4.10)</td><td>0.055</td><td>3.34 (1.02–10.92)</td></tr></table>
<table><tr><td colspan="3">Multivariate analysis</td></tr><tr><td>HR (95% CI)</td><td>P-value*</td><td rowspan="19"></td></tr><tr><td>HBP1 IHC</td><td rowspan="18"></td></tr><tr><td></td></tr><tr><td>0.042</td></tr><tr><td>Ξ²-catenin nuclear accumulation</td></tr><tr><td></td></tr><tr><td>0.041</td></tr><tr><td>Smoking habit</td></tr><tr><td></td></tr><tr><td>0.326</td></tr><tr><td>Tumour type</td></tr><tr><td></td></tr><tr><td>0.784</td></tr><tr><td>Tumour stage</td></tr><tr><td></td></tr><tr><td>0.532</td></tr><tr><td>Lymph node status</td></tr><tr><td></td></tr><tr><td>0.046</td></tr></table>
29ed74125247f31e7b52b1d0c46784513a9dfb9ec69941577769d200f44d7388.png
simple
<table><tr><td></td><td>AF Group</td><td>Control group</td><td>P value</td></tr><tr><td>Age (year)</td><td>3/0&#177;69</td><td>8/0&#177;72</td><td>0.27</td></tr><tr><td>Male</td><td>13</td><td>13</td><td></td></tr><tr><td>Female</td><td>12</td><td>12</td><td></td></tr><tr><td>Low Education (%)</td><td>5/0&#177;25</td><td>3/0&#177;33</td><td>0.08</td></tr><tr><td>Smoke (%)</td><td>1/0&#177;14</td><td>2/0&#177;17</td><td>0.12</td></tr><tr><td>BMI</td><td>4/0&#177;26</td><td>2/0&#177;27</td><td>0.17</td></tr></table>
<table><tr><td></td><td>AF Group</td><td>Control group</td><td>P value</td></tr></table>
<table><tr><td>Age (year)</td><td>3/0Β±69</td><td>8/0Β±72</td><td>0.27</td></tr><tr><td>Male</td><td>13</td><td>13</td><td></td></tr><tr><td>Female</td><td>12</td><td>12</td><td></td></tr><tr><td>Low Education (%)</td><td>5/0Β±25</td><td>3/0Β±33</td><td>0.08</td></tr><tr><td>Smoke (%)</td><td>1/0Β±14</td><td>2/0Β±17</td><td>0.12</td></tr><tr><td>BMI</td><td>4/0Β±26</td><td>2/0Β±27</td><td>0.17</td></tr></table>
bede2c2e88880238445411818b1236bf32ca2638b2898c08bde2eae427aaeaa3.png
complex
<table><tr><td rowspan="3">Mutated gene</td><td rowspan="3">Expressing neurons+</td><td colspan="4">Number of turns/min for the 5th minute</td><td rowspan="3"><i>p</i> value</td></tr><tr><td colspan="2">Wild-type control</td><td colspan="2">Mutant</td></tr><tr><td>150 mOsm</td><td>400 mOsm</td><td>150 mOsm</td><td>400 mOsm</td></tr><tr><td><i>gpa-8</i></td><td>AQR, PQR, URX</td><td>9.58 &#177; 1.02 (24)</td><td>24.61 &#177; 1.51 (23)</td><td>7.33 &#177; 0.85 (21)</td><td>20.67 &#177; 1.89 (21)</td><td>0.538</td></tr><tr><td><i>gpa-13</i></td><td>PQR</td><td>7.19 &#177; 1.13 (16)</td><td>16.13 &#177; 2.91 (15)</td><td>9.63 &#177; 2.23 (16)</td><td>21.69 &#177; 1.98 (16)</td><td>0.467</td></tr><tr><td><i>gcy-1</i></td><td>URX</td><td>8.19 &#177; 1.50 (16)</td><td>29.00 &#177; 1.91 (16)</td><td>5.88 &#177; 1.01 (16)</td><td>25.31 &#177; 2.22 (16)</td><td>0.691</td></tr><tr><td><i>gcy-25</i></td><td>AQR, PQR, URX</td><td>11.07 &#177; 1.52 (15)</td><td>26.73 &#177; 2.10 (15)</td><td>8.50 &#177; 1.10 (16)</td><td>23.13 &#177; 1.26 (16)</td><td>0.734</td></tr><tr><td><i>gcy-28</i></td><td>Widely expressed</td><td>9.31 &#177; 1.76 (16)</td><td>24.63 &#177; 2.40 (16)</td><td>9.00 &#177; 1.14 (16)</td><td>32.06 &#177; 2.18 (16)</td><td>0.049#</td></tr><tr><td><i>gcy-32</i></td><td>AQR, PQR, URX</td><td>11.06 &#177; 1.80 (16)</td><td>27.60 &#177; 1.77 (15)</td><td>7.71 &#177; 0.71 (14)</td><td>25.81 &#177; 1.61 (16)</td><td>0.622</td></tr><tr><td><i>gcy-33</i></td><td>AQR, PQR, URX</td><td>10.94 &#177; 2.24 (16)</td><td>22.88 &#177; 2.67 (16)</td><td>8.88 &#177; 1.13 (16)</td><td>18.87 &#177; 2.34 (15)</td><td>0.655</td></tr><tr><td><i>gcy-34</i></td><td>AQR, PQR, URX</td><td>7.33 &#177; 0.84 (15)</td><td>22.94 &#177; 2.14 (16)</td><td>7.73 &#177; 1.01 (15)</td><td>20.19 &#177; 2.37 (16)</td><td>0.377</td></tr><tr><td><i>gcy-35</i></td><td>AQR, PQR, URX</td><td>9.83 &#177; 1.39 (23)</td><td>30.08 &#177; 1.25 (24)</td><td>9.68 &#177; 1.26 (22)</td><td>28.46 &#177; 1.40 (24)</td><td>0.578</td></tr><tr><td><i>gcy-36</i></td><td>AQR, PQR, URX</td><td>9.83 &#177; 1.39 (23)</td><td>30.08 &#177; 1.25 (24)</td><td>8.42 &#177; 1.18 (24)</td><td>27.39 &#177; 1.99 (23)</td><td>0.665</td></tr><tr><td><i>gcy-37</i></td><td>AQR, PQR, URX</td><td>9.94 &#177; 1.25 (16)</td><td>26.69 &#177; 2.15 (16)</td><td>6.93 &#177; 0.73 (15)</td><td>21.87 &#177; 2.14 (15)</td><td>0.592</td></tr></table>
<table><tr><td rowspan="3">Mutated gene</td><td rowspan="3">Expressing neurons+</td><td colspan="4">Number of turns/min for the 5th minute</td><td rowspan="3">p value</td></tr><tr><td colspan="2">Wild-type control</td><td colspan="2">Mutant</td></tr><tr><td>150 mOsm</td><td>400 mOsm</td><td>150 mOsm</td><td>400 mOsm</td></tr><tr><td>gpa-8</td><td>AQR, PQR, URX</td><td>9.58 Β± 1.02 (24)</td><td>24.61 Β± 1.51 (23)</td><td>7.33 Β± 0.85 (21)</td><td>20.67 Β± 1.89 (21)</td><td>0.538</td></tr></table>
<table><tr><td rowspan="3">Mutated gene</td><td rowspan="3">Expressing neurons+</td><td colspan="4">Number of turns/min for the 5th minute</td><td rowspan="3">p value</td></tr><tr><td colspan="2">Wild-type control</td><td colspan="2">Mutant</td></tr><tr><td>150 mOsm</td><td>400 mOsm</td><td>150 mOsm</td><td>400 mOsm</td></tr><tr><td>gpa-13</td><td>PQR</td><td>7.19 Β± 1.13 (16)</td><td>16.13 Β± 2.91 (15)</td><td>9.63 Β± 2.23 (16)</td><td>21.69 Β± 1.98 (16)</td><td>0.467</td></tr><tr><td>gcy-1</td><td>URX</td><td>8.19 Β± 1.50 (16)</td><td>29.00 Β± 1.91 (16)</td><td>5.88 Β± 1.01 (16)</td><td>25.31 Β± 2.22 (16)</td><td>0.691</td></tr><tr><td>gcy-25</td><td>AQR, PQR, URX</td><td>11.07 Β± 1.52 (15)</td><td>26.73 Β± 2.10 (15)</td><td>8.50 Β± 1.10 (16)</td><td>23.13 Β± 1.26 (16)</td><td>0.734</td></tr><tr><td>gcy-28</td><td>Widely expressed</td><td>9.31 Β± 1.76 (16)</td><td>24.63 Β± 2.40 (16)</td><td>9.00 Β± 1.14 (16)</td><td>32.06 Β± 2.18 (16)</td><td>0.049#</td></tr><tr><td>gcy-32</td><td>AQR, PQR, URX</td><td>11.06 Β± 1.80 (16)</td><td>27.60 Β± 1.77 (15)</td><td>7.71 Β± 0.71 (14)</td><td>25.81 Β± 1.61 (16)</td><td>0.622</td></tr><tr><td>gcy-33</td><td>AQR, PQR, URX</td><td>10.94 Β± 2.24 (16)</td><td>22.88 Β± 2.67 (16)</td><td>8.88 Β± 1.13 (16)</td><td>18.87 Β± 2.34 (15)</td><td>0.655</td></tr><tr><td>gcy-34</td><td>AQR, PQR, URX</td><td>7.33 Β± 0.84 (15)</td><td>22.94 Β± 2.14 (16)</td><td>7.73 Β± 1.01 (15)</td><td>20.19 Β± 2.37 (16)</td><td>0.377</td></tr><tr><td>gcy-35</td><td>AQR, PQR, URX</td><td>9.83 Β± 1.39 (23)</td><td>30.08 Β± 1.25 (24)</td><td>9.68 Β± 1.26 (22)</td><td>28.46 Β± 1.40 (24)</td><td>0.578</td></tr><tr><td>gcy-36</td><td>AQR, PQR, URX</td><td>9.83 Β± 1.39 (23)</td><td>30.08 Β± 1.25 (24)</td><td>8.42 Β± 1.18 (24)</td><td>27.39 Β± 1.99 (23)</td><td>0.665</td></tr><tr><td>gcy-37</td><td>AQR, PQR, URX</td><td>9.94 Β± 1.25 (16)</td><td>26.69 Β± 2.15 (16)</td><td>6.93 Β± 0.73 (15)</td><td>21.87 Β± 2.14 (15)</td><td>0.592</td></tr></table>
744bed717437b61b8c29b60f02862becf987137ea7968ffe2231c8f680f5f9eb.png
simple
<table><tr><td>Line</td><td>Independent lines</td><td>Individual plants per line</td><td>Repetitions per line</td><td>Total <i>n</i> of cells</td><td>Total <i>n</i> of Golgi bodies</td></tr><tr><td>STtmd-mRFP/GFP-HDEL</td><td>1</td><td>5</td><td>3</td><td>41</td><td>332</td></tr><tr><td>mRFP-AtCASP/GFP-HDEL</td><td>2</td><td>7 and 4</td><td>3 and 2</td><td>4632</td><td>388240</td></tr><tr><td>mRFP-AtCASP-&#8710;CC/GFP-HDEL</td><td>2</td><td>6 and 4</td><td>3 and 2</td><td>4323</td><td>456174</td></tr></table>
<table><tr><td>Line</td><td>Independent lines</td><td>Individual plants per line</td><td>Repetitions per line</td><td>Total n of cells</td><td>Total n of Golgi bodies</td></tr></table>
<table><tr><td>STtmd-mRFP/GFP-HDEL</td><td>1</td><td>5</td><td>3</td><td>41</td><td>332</td></tr><tr><td>mRFP-AtCASP/GFP-HDEL</td><td>2</td><td>7 and 4</td><td>3 and 2</td><td>4632</td><td>388240</td></tr><tr><td>mRFP-AtCASP-βˆ†CC/GFP-HDEL</td><td>2</td><td>6 and 4</td><td>3 and 2</td><td>4323</td><td>456174</td></tr></table>
24627ae348963735b5aaa376fb6f525263256898e0460b3781063b662423b287.png
complex
<table><tr><td rowspan="2">Pediatric-onset CD patients</td><td>Low BMD</td><td>Normal BMD</td><td rowspan="2">p-value</td></tr><tr><td>Z-score&lt;&#8722;1</td><td>Z-score &#8805;&#8722;1</td></tr><tr><td>n=77</td><td>n=46</td><td>n=31</td><td> </td></tr><tr><td>%</td><td>60%</td><td>40%</td><td> </td></tr><tr><td><i>NOD2 </i>variant n (%)</td><td>24 (52%)</td><td>10 (32%)</td><td>p=0.10</td></tr><tr><td>One variant allele</td><td>17</td><td>5</td><td>p=0.061</td></tr><tr><td>Two variant alleles</td><td>7</td><td>5</td><td>p=0.75</td></tr><tr><td>Homozygous variant alleles</td><td>7</td><td>0</td><td>p=0.037*</td></tr><tr><td>Gender: female/male in %</td><td>45/55</td><td>48/52</td><td>p=0.89</td></tr><tr><td>Age: y</td><td> </td><td> </td><td> </td></tr><tr><td>mean/SD</td><td>25/12.8</td><td>24/13.9</td><td>p=0.62</td></tr><tr><td>median/interquartile range</td><td>21/17-30</td><td>19/15-29</td><td>p=0.29</td></tr><tr><td>average disease duration/SD</td><td>12.2/11.6</td><td>11.6/10.8</td><td>p=0.84</td></tr><tr><td>Age at diagnosis: y</td><td> </td><td> </td><td> </td></tr><tr><td>mean/SD</td><td>13/3.6</td><td>12/5.1</td><td>p=0.33</td></tr><tr><td>median/interquartile range</td><td>14/11-16</td><td>13/10-17</td><td>p=0.69</td></tr><tr><td>Localization: n (%)</td><td> </td><td> </td><td> </td></tr><tr><td>L1 ileal</td><td>8 (17%)</td><td>9 (29%)</td><td>p=0.27</td></tr><tr><td>L2 colonic</td><td>8 (17%)</td><td>6 (19%)</td><td>p=1.0</td></tr><tr><td>L3 ileocolonic</td><td>30 (65%)</td><td>16 (52%)</td><td>p=0.25</td></tr><tr><td>L4 isolated upper disease</td><td>0 (0%)</td><td>0 (0%)</td><td>p=1.0</td></tr><tr><td>Upper GI involvement</td><td>15 (33%)</td><td>13 (42%)</td><td>p=0.47</td></tr><tr><td>Behaviour: n (%)</td><td> </td><td> </td><td> </td></tr><tr><td>B1 non-stricturing/penetrating</td><td>27 (59%)</td><td>20 (65%)</td><td>p=0.64</td></tr><tr><td>B2 stricturing</td><td>11 (23%)</td><td>6 (19%)</td><td>p=0.78</td></tr><tr><td>B3 penetrating intern</td><td>6 (13%)</td><td>3 (10%)</td><td>p=0.73</td></tr><tr><td>B3p penetrating perianal</td><td>9 (19%)</td><td>3 (10%)</td><td>p=0.34</td></tr><tr><td>Underweight at diagnosis</td><td>14/27 (52%)</td><td>5/22 (32%)</td><td>p=0.0453*</td></tr><tr><td>Underweight in 1y follow-up</td><td>14 (30%)</td><td>2 (6%)</td><td>p=0.0113*</td></tr><tr><td>Short stature</td><td>5 (11%)</td><td>1 (3%)</td><td>p=0.39</td></tr><tr><td>Treatment: n (%)</td><td> </td><td> </td><td> </td></tr><tr><td>Steroid dependent/refractory</td><td>23 (50%)</td><td>9 (29%)</td><td>p=0.10</td></tr><tr><td>Azathioprine / MTX</td><td>35 (76%)</td><td>15 (48%)</td><td>p=0.016*</td></tr><tr><td>Anti-TNF&#945;-antibody</td><td>20 (44%)</td><td>7 (26%)</td><td>p=0.09</td></tr></table>
<table><tr><td rowspan="2">Pediatric-onset CD patients</td><td>Low BMD</td><td>Normal BMD</td><td rowspan="2">p-value</td></tr><tr><td>Z-score<βˆ’1</td><td>Z-score β‰₯βˆ’1</td></tr><tr><td>n=77</td><td>n=46</td><td>n=31</td><td></td></tr><tr><td>%</td><td>60%</td><td>40%</td><td></td></tr><tr><td>NOD2 variant n (%)</td><td>24 (52%)</td><td>10 (32%)</td><td>p=0.10</td></tr><tr><td>One variant allele</td><td>17</td><td>5</td><td>p=0.061</td></tr><tr><td>Two variant alleles</td><td>7</td><td>5</td><td>p=0.75</td></tr><tr><td>Homozygous variant alleles</td><td>7</td><td>0</td><td>p=0.037*</td></tr><tr><td>Gender: female/male in %</td><td>45/55</td><td>48/52</td><td>p=0.89</td></tr><tr><td>Age: y</td><td></td><td></td><td></td></tr><tr><td>mean/SD</td><td>25/12.8</td><td>24/13.9</td><td>p=0.62</td></tr><tr><td>median/interquartile range</td><td>21/17-30</td><td>19/15-29</td><td>p=0.29</td></tr><tr><td>average disease duration/SD</td><td>12.2/11.6</td><td>11.6/10.8</td><td>p=0.84</td></tr><tr><td>Age at diagnosis: y</td><td></td><td></td><td></td></tr><tr><td>mean/SD</td><td>13/3.6</td><td>12/5.1</td><td>p=0.33</td></tr><tr><td>median/interquartile range</td><td>14/11-16</td><td>13/10-17</td><td>p=0.69</td></tr><tr><td>Localization: n (%)</td><td></td><td></td><td></td></tr><tr><td>L1 ileal</td><td>8 (17%)</td><td>9 (29%)</td><td>p=0.27</td></tr><tr><td>L2 colonic</td><td>8 (17%)</td><td>6 (19%)</td><td>p=1.0</td></tr><tr><td>L3 ileocolonic</td><td>30 (65%)</td><td>16 (52%)</td><td>p=0.25</td></tr><tr><td>L4 isolated upper disease</td><td>0 (0%)</td><td>0 (0%)</td><td>p=1.0</td></tr><tr><td>Upper GI involvement</td><td>15 (33%)</td><td>13 (42%)</td><td>p=0.47</td></tr><tr><td>Behaviour: n (%)</td><td></td><td></td><td></td></tr></table>
<table><tr><td rowspan="2">Pediatric-onset CD patients</td><td>Low BMD</td><td>Normal BMD</td><td rowspan="2">p-value</td></tr><tr><td>Z-score<βˆ’1</td><td>Z-score β‰₯βˆ’1</td></tr><tr><td>n=77</td><td>n=46</td><td>n=31</td><td></td></tr><tr><td>%</td><td>60%</td><td>40%</td><td></td></tr><tr><td>B1 non-stricturing/penetrating</td><td>27 (59%)</td><td>20 (65%)</td><td>p=0.64</td></tr><tr><td>B2 stricturing</td><td>11 (23%)</td><td>6 (19%)</td><td>p=0.78</td></tr><tr><td>B3 penetrating intern</td><td>6 (13%)</td><td>3 (10%)</td><td>p=0.73</td></tr><tr><td>B3p penetrating perianal</td><td>9 (19%)</td><td>3 (10%)</td><td>p=0.34</td></tr><tr><td>Underweight at diagnosis</td><td>14/27 (52%)</td><td>5/22 (32%)</td><td>p=0.0453*</td></tr><tr><td>Underweight in 1y follow-up</td><td>14 (30%)</td><td>2 (6%)</td><td>p=0.0113*</td></tr><tr><td>Short stature</td><td>5 (11%)</td><td>1 (3%)</td><td>p=0.39</td></tr><tr><td>Treatment: n (%)</td><td></td><td></td><td></td></tr><tr><td>Steroid dependent/refractory</td><td>23 (50%)</td><td>9 (29%)</td><td>p=0.10</td></tr><tr><td>Azathioprine / MTX</td><td>35 (76%)</td><td>15 (48%)</td><td>p=0.016*</td></tr><tr><td>Anti-TNFΞ±-antibody</td><td>20 (44%)</td><td>7 (26%)</td><td>p=0.09</td></tr></table>
a6360c041cb0c5cfa36d73e0c3f368d5819388d2fd4bb3027b50ba4d9705a7eb.png
simple
<table><tr><td>Lipids (abnormal range)</td><td>Females</td><td>Males</td><td>P value *</td></tr><tr><td>Cholesterol (&gt; 5.0 mmol/L)</td><td>211/313 (67.4%)</td><td>66/ 123 (53.7%)</td><td>&#8804; 0.01</td></tr><tr><td>Triglycerides (&gt; 1.92 mmol/L)</td><td>108/313 (34.5%)</td><td>50/ 123 (40.7%)</td><td>ns</td></tr><tr><td>HDL cholesterol (&lt; 1.00 mmol/L)</td><td>9/199 (4.5%)</td><td>13/72 (18.1%)</td><td>&#8804; 0.001</td></tr><tr><td>LDL cholesterol (&gt; 3.00 mmol/L)</td><td>121/194 (62.4%)</td><td>37/66 (56.1%)</td><td>ns</td></tr></table>
<table><tr><td>Lipids (abnormal range)</td><td>Females</td><td>Males</td><td>P value *</td></tr><tr><td>Cholesterol (> 5.0 mmol/L)</td><td>211/313 (67.4%)</td><td>66/ 123 (53.7%)</td><td>≀ 0.01</td></tr></table>
<table><tr><td>Lipids (abnormal range)</td><td>Females</td><td>Males</td><td>P value *</td></tr><tr><td>Triglycerides (> 1.92 mmol/L)</td><td>108/313 (34.5%)</td><td>50/ 123 (40.7%)</td><td>ns</td></tr><tr><td>HDL cholesterol (< 1.00 mmol/L)</td><td>9/199 (4.5%)</td><td>13/72 (18.1%)</td><td>≀ 0.001</td></tr><tr><td>LDL cholesterol (> 3.00 mmol/L)</td><td>121/194 (62.4%)</td><td>37/66 (56.1%)</td><td>ns</td></tr></table>
d17abdaab62b9bafbd6a64ec568fd5326ee1ebd5db8839bf71ddc88daf2fa84d.png
simple
<table><tr><td>Sensor Error</td><td>Parameter Value</td></tr><tr><td>Constant bias of gyroscope</td><td>0.002 (&#176;/h)</td></tr><tr><td>Constant bias of accelerometer</td><td>1.96 &#215; 10<sup>-4</sup> (m/s<sup>2</sup>)</td></tr><tr><td>Scale factor error of gyroscope</td><td>5 &#215; 10<sup>-6</sup> (&#176;/h)<sup>-1</sup></td></tr><tr><td>Installation error of gyroscope</td><td>2 &#215; 10<sup>-10</sup> (&#176;/h)</td></tr></table>
<table><tr><td>Sensor Error</td><td>Parameter Value</td></tr><tr><td>Constant bias of gyroscope</td><td>0.002 (Β°/h)</td></tr></table>
<table><tr><td>Constant bias of accelerometer</td><td>1.96 Γ— 10-4 (m/s2)</td></tr><tr><td>Scale factor error of gyroscope</td><td>5 Γ— 10-6 (Β°/h)-1</td></tr><tr><td>Installation error of gyroscope</td><td>2 Γ— 10-10 (Β°/h)</td></tr></table>
127459f66a0903da193a397f214e689ba9a6363606ed624dc58ea7cefa623475.png
complex
<table><tr><td></td><td>No.</td><td>Mean &#177; SD</td><td>Median (range)</td><td><i>p</i>-Value</td></tr><tr><td colspan="5">Sex</td></tr><tr><td> Male</td><td>49</td><td>9.21 &#177; 7.09</td><td>7.77 (27.88)</td><td></td></tr><tr><td> Female</td><td>34</td><td>7.72 &#177; 5.21</td><td>6.40 (19.19)</td><td>0.2966</td></tr><tr><td colspan="5">Residence</td></tr><tr><td> Rural</td><td>30</td><td>8.52 &#177; 6.31</td><td>7.31 (20.11)</td><td>0.9281</td></tr><tr><td> Urban</td><td>53</td><td>8.65 &#177; 6.51</td><td>6.86 (27.42)</td><td></td></tr><tr><td colspan="5">Smoking</td></tr><tr><td> Yes</td><td>32</td><td>8.75 &#177; 6.86</td><td>7.08 (27.42)</td><td></td></tr><tr><td> No</td><td>51</td><td>8.5 &#177; 6.16</td><td>6.86 (26.96)</td><td>0.8634</td></tr><tr><td colspan="5">Occupation</td></tr><tr><td> Farmer</td><td>10</td><td>13.34 &#177; 8.29</td><td>11.88 (1.83&#8211;28.79)</td><td>0.0827</td></tr><tr><td> Housewife</td><td>29</td><td>7.56 &#177; 6.05</td><td>5.94 (0.91&#8211;27.88)</td><td></td></tr><tr><td> Industrial</td><td>19</td><td>8.68 &#177; 5.46</td><td>7.77 (0.91&#8211;16.45)</td><td></td></tr><tr><td> Professional</td><td>25</td><td>7.84 &#177; 6.14</td><td>5.03 (1.37&#8211;25.14)</td><td></td></tr></table>
<table><tr><td></td><td>No.</td><td>Mean Β± SD</td></tr><tr><td colspan="3">Sex</td></tr><tr><td>Male</td><td>49</td><td>9.21 Β± 7.09</td></tr><tr><td>Female</td><td>34</td><td>7.72 Β± 5.21</td></tr><tr><td colspan="3">Residence</td></tr><tr><td>Rural</td><td>30</td><td>8.52 Β± 6.31</td></tr><tr><td>Urban</td><td>53</td><td>8.65 Β± 6.51</td></tr><tr><td colspan="3">Smoking</td></tr><tr><td>Yes</td><td>32</td><td>8.75 Β± 6.86</td></tr><tr><td>No</td><td>51</td><td>8.5 Β± 6.16</td></tr><tr><td colspan="3">Occupation</td></tr><tr><td>Farmer</td><td>10</td><td>13.34 Β± 8.29</td></tr><tr><td>Housewife</td><td>29</td><td>7.56 Β± 6.05</td></tr><tr><td>Industrial</td><td>19</td><td>8.68 Β± 5.46</td></tr><tr><td>Professional</td><td>25</td><td>7.84 Β± 6.14</td></tr></table>
<table><tr><td>Median (range)</td><td>p-Value</td></tr><tr><td colspan="2">Sex</td></tr><tr><td>7.77 (27.88)</td><td></td></tr><tr><td>6.40 (19.19)</td><td>0.2966</td></tr><tr><td colspan="2">Residence</td></tr><tr><td>7.31 (20.11)</td><td>0.9281</td></tr><tr><td>6.86 (27.42)</td><td></td></tr><tr><td colspan="2">Smoking</td></tr><tr><td>7.08 (27.42)</td><td></td></tr><tr><td>6.86 (26.96)</td><td>0.8634</td></tr><tr><td colspan="2">Occupation</td></tr><tr><td>11.88 (1.83–28.79)</td><td>0.0827</td></tr><tr><td>5.94 (0.91–27.88)</td><td></td></tr><tr><td>7.77 (0.91–16.45)</td><td></td></tr><tr><td>5.03 (1.37–25.14)</td><td></td></tr></table>
e93712c10a1c0d48ca14f2147f82f7b2d0198e7318cd91dde1ab68201d6b2028.png
complex
<table><tr><td rowspan="3"></td><td colspan="4">Fulfilment of ASAS axSpA criteria</td></tr><tr><td colspan="2">SPACE</td><td colspan="2">DESIR</td></tr><tr><td>OR (95% CI)</td><td><i>P</i>- value</td><td>OR (95% CI)</td><td><i>P</i>- value</td></tr><tr><td>Any PFH</td><td>2.1 (1.4-3.1)</td><td>&lt;0.001</td><td>1.3 (1.0-1.9)</td><td>0.091</td></tr><tr><td>AS</td><td>3.3 (2.0-5.3)</td><td>&lt;0.001</td><td>2.1 (1.3-3.3)</td><td>&lt;0.001</td></tr><tr><td>AAU</td><td>7.4 (2.5-21.7)</td><td>&lt;0.001</td><td>5.0 (1.5-16.7)</td><td>0.009</td></tr><tr><td>ReA</td><td>0.6 (0.2-1.9)</td><td>0.421</td><td>0.3 (0.05-1.5)</td><td>0.132</td></tr><tr><td>IBD</td><td>1.1 (0.5-2.2)</td><td>0.798</td><td>0.8 (0.4-1.6)</td><td>0.521</td></tr><tr><td>Psoriasis</td><td>1.2 (0.8-2.0)</td><td>0.388</td><td>1.2 (0.8-1.8)</td><td>0.464</td></tr></table>
<table><tr><td rowspan="2"></td><td colspan="4">Fulfilment of ASAS axSpA criteria</td></tr><tr><td colspan="2">SPACE</td><td colspan="2">DESIR</td></tr></table>
<table><tr><td></td><td>OR (95% CI)</td><td>P- value</td><td>OR (95% CI)</td><td>P- value</td></tr><tr><td>Any PFH</td><td>2.1 (1.4-3.1)</td><td><0.001</td><td>1.3 (1.0-1.9)</td><td>0.091</td></tr><tr><td>AS</td><td>3.3 (2.0-5.3)</td><td><0.001</td><td>2.1 (1.3-3.3)</td><td><0.001</td></tr><tr><td>AAU</td><td>7.4 (2.5-21.7)</td><td><0.001</td><td>5.0 (1.5-16.7)</td><td>0.009</td></tr><tr><td>ReA</td><td>0.6 (0.2-1.9)</td><td>0.421</td><td>0.3 (0.05-1.5)</td><td>0.132</td></tr><tr><td>IBD</td><td>1.1 (0.5-2.2)</td><td>0.798</td><td>0.8 (0.4-1.6)</td><td>0.521</td></tr><tr><td>Psoriasis</td><td>1.2 (0.8-2.0)</td><td>0.388</td><td>1.2 (0.8-1.8)</td><td>0.464</td></tr></table>
31a6edfc74b2f71a8931c2b76a1f49a17783f1473461206a19075f6b335a9688.png
complex
<table><tr><td></td><td>Group PC(n = 27)</td><td>Group VC(n = 27)</td><td><i>p</i> value</td></tr><tr><td>Age (year)</td><td>44.4 &#177; 12.3</td><td>41.1 &#177; 100</td><td>NS</td></tr><tr><td>Weight (kg)</td><td>78.9 &#177; 8.8</td><td>79.5 &#177; 10.3</td><td>NS</td></tr><tr><td>Gender (M/F)</td><td>20/7</td><td>22/5</td><td>NS</td></tr><tr><td colspan="4">HR (beats/min)</td></tr><tr><td> Pre</td><td>79.7 &#177; 10.4</td><td>76.5 &#177; 12.7</td><td>NS</td></tr><tr><td> Prone</td><td>78.7 &#177; 11.0</td><td>73.1 &#177; 9.4</td><td>NS</td></tr><tr><td> Post</td><td>76.1 &#177; 94</td><td>74.8 &#177; 8.2</td><td>NS</td></tr><tr><td colspan="4">SAP (mmHg)</td></tr><tr><td> Pre</td><td>133 &#177; 12.9</td><td>132 &#177; 14.5</td><td>NS</td></tr><tr><td> Prone</td><td>116 &#177; 13.1</td><td>117 &#177; 14.0</td><td>NS</td></tr><tr><td> Post</td><td>125 &#177; 11.9</td><td>123 &#177; 12.7</td><td>NS</td></tr><tr><td colspan="4">MAP (mmHg)</td></tr><tr><td> Pre</td><td>103 &#177; 13.4</td><td>103 &#177; 15.4</td><td>NS</td></tr><tr><td> Prone</td><td>93.9 &#177; 13.6</td><td>94.1 &#177; 8.5</td><td>NS</td></tr><tr><td> Post</td><td>92.8 &#177; 14.1</td><td>96.2 &#177; 13.6</td><td>NS</td></tr></table>
<table><tr><td></td><td>Group PC(n = 27)</td><td>Group VC(n = 27)</td><td>p value</td></tr><tr><td>Age (year)</td><td>44.4 Β± 12.3</td><td>41.1 Β± 100</td><td>NS</td></tr><tr><td>Weight (kg)</td><td>78.9 Β± 8.8</td><td>79.5 Β± 10.3</td><td>NS</td></tr><tr><td>Gender (M/F)</td><td>20/7</td><td>22/5</td><td>NS</td></tr><tr><td colspan="4">HR (beats/min)</td></tr><tr><td>Pre</td><td>79.7 Β± 10.4</td><td>76.5 Β± 12.7</td><td>NS</td></tr><tr><td>Prone</td><td>78.7 Β± 11.0</td><td>73.1 Β± 9.4</td><td>NS</td></tr><tr><td>Post</td><td>76.1 Β± 94</td><td>74.8 Β± 8.2</td><td>NS</td></tr><tr><td colspan="4">SAP (mmHg)</td></tr></table>
<table><tr><td>Pre</td><td>133 Β± 12.9</td><td>132 Β± 14.5</td><td>NS</td></tr><tr><td>Prone</td><td>116 Β± 13.1</td><td>117 Β± 14.0</td><td>NS</td></tr><tr><td>Post</td><td>125 Β± 11.9</td><td>123 Β± 12.7</td><td>NS</td></tr><tr><td colspan="4">MAP (mmHg)</td></tr><tr><td>Pre</td><td>103 Β± 13.4</td><td>103 Β± 15.4</td><td>NS</td></tr><tr><td>Prone</td><td>93.9 Β± 13.6</td><td>94.1 Β± 8.5</td><td>NS</td></tr><tr><td>Post</td><td>92.8 Β± 14.1</td><td>96.2 Β± 13.6</td><td>NS</td></tr></table>
e59e6e666fda29dc8da043b44ba40e7fd9cac1788f9e09b38f750ad5d81defe0.png
simple
<table><tr><td></td><td>Mean Value (m)</td></tr><tr><td>Set 1</td><td>0.2189 &#177; 0.0003</td></tr><tr><td>Set 2</td><td>0.2117 &#177; 0.0003</td></tr><tr><td>Set 3</td><td>0.2189 &#177; 0.0003</td></tr><tr><td>Set 4</td><td>0.2087 &#177; 0.0003</td></tr></table>
<table><tr><td></td><td>Mean Value (m)</td></tr><tr><td>Set 1</td><td>0.2189 Β± 0.0003</td></tr><tr><td>Set 2</td><td>0.2117 Β± 0.0003</td></tr><tr><td>Set 3</td><td>0.2189 Β± 0.0003</td></tr></table>
<table><tr><td></td><td>Mean Value (m)</td></tr><tr><td>Set 4</td><td>0.2087 Β± 0.0003</td></tr></table>
698978dd46068d7707435b0cad4ade5c9f79cc1a98712d8a801870e442bca2f7.png
complex
<table><tr><td rowspan="3">Discovery method</td><td colspan="4">Predicted validation success (%)</td></tr><tr><td colspan="2">Infinium</td><td colspan="2">Axiom</td></tr><tr><td>Predictive</td><td>Filtering</td><td>Predictive</td><td>Filtering</td></tr><tr><td>BOWTIE2</td><td>75.7</td><td>45.6</td><td>83.3</td><td>61.7</td></tr><tr><td>BWA</td><td>72.1</td><td>39.7</td><td>78.5</td><td>54.6</td></tr><tr><td>NEWBLER</td><td>46.8</td><td>27.3</td><td>48.9</td><td>35.5</td></tr><tr><td>SWAP454</td><td>57.0</td><td>34.6</td><td>61.8</td><td>45.9</td></tr></table>
<table><tr><td rowspan="3">Discovery method</td><td colspan="4">Predicted validation success (%)</td></tr><tr><td colspan="2">Infinium</td><td colspan="2">Axiom</td></tr><tr><td>Predictive</td><td>Filtering</td><td>Predictive</td><td>Filtering</td></tr><tr><td>BOWTIE2</td><td>75.7</td><td>45.6</td><td>83.3</td><td>61.7</td></tr><tr><td>BWA</td><td>72.1</td><td>39.7</td><td>78.5</td><td>54.6</td></tr><tr><td>NE</td><td>46</td><td>27</td><td></td><td>35.</td></tr></table>
<table><tr><td>WBLER</td><td>.8</td><td>.3</td><td>48.9</td><td>5</td></tr><tr><td>SWAP454</td><td>57.0</td><td>34.6</td><td>61.8</td><td>45.9</td></tr></table>
b509c5ef347d1f663cd02a99f68591f14d849941fe565162e6b0c0e6fd65cfdc.png
complex
<table><tr><td>Gender</td><td colspan="2">Reporting</td></tr><tr><td></td><td>Plausible Reporters</td><td>Non-Plausible Reporters</td></tr><tr><td>Female</td><td>57.3% (<i>n</i> = 311)</td><td>46.7% (<i>n</i> = 685)</td></tr><tr><td>Male</td><td>42.7% (<i>n</i> = 232)</td><td>53.3% (<i>n</i> = 781)</td></tr></table>
<table><tr><td></td><td colspan="2">R</td></tr></table>
<table><tr><td>Gender</td><td colspan="2">eporting</td></tr><tr><td></td><td>Plausible Reporters</td><td>Non-Plausible Reporters</td></tr><tr><td>Female</td><td>57.3% (n = 311)</td><td>46.7% (n = 685)</td></tr><tr><td>Male</td><td>42.7% (n = 232)</td><td>53.3% (n = 781)</td></tr></table>
e3717bc62a5cbb9501dced700e5d16028ef5dabfcb345c4b3cc458e618ef3036.png
simple
<table><tr><td>Gene name</td><td>Accession number</td><td>Primer sequences (forward/reverse)</td><td>Tm(&#176;C)</td><td>Amplication length</td><td>Amplification efficacy (%)</td></tr><tr><td>h2afz</td><td>NM_016750</td><td>GTGGACTGTATCTCTGTGAA/GGTTGGTTGGAAGGCTAA</td><td>60</td><td>89</td><td>92.1</td></tr><tr><td>sdha</td><td>NM_023281</td><td>ATTCATTGTCTACTTCTCACT/AGGGTTTATTTGGCTTACA</td><td>58</td><td>108</td><td>90.6</td></tr><tr><td>tgfb1</td><td>NM_011577</td><td>TATACTGAGACACCTTGG/GTGATAGTCCTGAATAATTTG</td><td>55</td><td>83</td><td>97.2</td></tr><tr><td>gapdh</td><td>NM_008084</td><td>AGTGGCAAAGTGGAGATT/GTGGAGTCATACTGGAACA</td><td>60</td><td>83</td><td>91.5</td></tr><tr><td>actb</td><td>NM_007393</td><td>ATCTTCCGCCTTAATACT/GCCTTCATACATCAAGTT</td><td>56</td><td>98</td><td>90.7</td></tr><tr><td>sptbn</td><td>NM_175836</td><td>TCTAATGGTTACTTGCTTGT/CAATAGTTACAGTGACAGAGA</td><td>55</td><td>101</td><td>91.2</td></tr><tr><td>ablim</td><td>NM_178688</td><td>GTATTCAGTGTTCACAGT/AATAGCATTAACCAGTAAGA</td><td>55</td><td>106</td><td>90.1</td></tr><tr><td>ywhaz</td><td>NM_001253807</td><td>CAGTAGATGGAGAAAGATTTGC/GGGACAATTAGGGAAGTAAGT</td><td>60</td><td>92</td><td>93.5</td></tr><tr><td>wrnip</td><td>NM_030215</td><td>ATGAGTAGGATGCTTGTA/TAACCACCTCCATCTATG</td><td>56</td><td>130</td><td>91.6</td></tr><tr><td>18 s</td><td>X00686</td><td>CGCCGCTAGAGGTGAAATTCT/CGAACCTCCGACTTTCGTTCT</td><td>60</td><td>102</td><td>93.6</td></tr></table>
<table><tr><td>Gene name</td><td>Accession number</td><td>Primer sequences (forward/reverse)</td><td>Tm(Β°C)</td><td>Amplication length</td><td>Amplification efficacy (%)</td></tr><tr><td>h2afz</td><td>NM_016750</td><td>GTGGACTGTATCTCTGTGAA/GGTTGGTTGGAAGGCTAA</td><td>60</td><td>89</td><td>92.1</td></tr><tr><td>sdha</td><td>NM_023281</td><td>ATTCATTGTCTACTTCTCACT/AGGGTTTATTTGGCTTACA</td><td>58</td><td>108</td><td>90.6</td></tr><tr><td>tgfb1</td><td>NM_011577</td><td>TATACTGAGACACCTTGG/GTGATAGTCCTGAATAATTTG</td><td>55</td><td>83</td><td>97.2</td></tr><tr><td>gapdh</td><td>NM_008084</td><td>AGTGGCAAAGTGGAGATT/GTGGAGTCATACTGGAACA</td><td>60</td><td>83</td><td>91.5</td></tr><tr><td>actb</td><td>NM_007393</td><td>ATCTTCCGCCTTAATACT/GCCTTCATACATCAAGTT</td><td>56</td><td>98</td><td>90.7</td></tr></table>
<table><tr><td>sptbn</td><td>NM_175836</td><td>TCTAATGGTTACTTGCTTGT/CAATAGTTACAGTGACAGAGA</td><td>55</td><td>101</td><td>91.2</td></tr><tr><td>ablim</td><td>NM_178688</td><td>GTATTCAGTGTTCACAGT/AATAGCATTAACCAGTAAGA</td><td>55</td><td>106</td><td>90.1</td></tr><tr><td>ywhaz</td><td>NM_001253807</td><td>CAGTAGATGGAGAAAGATTTGC/GGGACAATTAGGGAAGTAAGT</td><td>60</td><td>92</td><td>93.5</td></tr><tr><td>wrnip</td><td>NM_030215</td><td>ATGAGTAGGATGCTTGTA/TAACCACCTCCATCTATG</td><td>56</td><td>130</td><td>91.6</td></tr><tr><td>18 s</td><td>X00686</td><td>CGCCGCTAGAGGTGAAATTCT/CGAACCTCCGACTTTCGTTCT</td><td>60</td><td>102</td><td>93.6</td></tr></table>
fa391c08930f8ab468220568001e77ed88e0f4a312d1a23f04342c9b0e0e67b5.png
simple
<table><tr><td>Basins</td><td><i>Q</i> and SSC time span</td><td>Area (km<sup>2</sup>)</td><td>Characters</td></tr><tr><td>Da River Basin</td><td>1988&#8211;2004monthly</td><td>55000</td><td>No big dam in the upstream before 2004 Main vegetation cover: forest</td></tr><tr><td>Chiang Sean Basin</td><td>1986&#8211;1991monthly</td><td>185,000</td><td>No big dam before 1992 Main vegetation cover: grass and forest</td></tr><tr><td>Nam Muc Basin</td><td>1997&#8211;2006monthly</td><td>2,200</td><td>No big dam existedMain vegetation cover: forest</td></tr></table>
<table><tr><td>Basins</td><td>Q and SSC time span</td><td>Area (km2)</td><td>Characters</td></tr><tr><td>Da River Basin</td><td>1988–2004monthly</td><td>55000</td><td>No big dam in the upstream before 2004 Main vegetation cover: forest</td></tr></table>
<table><tr><td>Chiang Sean Basin</td><td>1986–1991monthly</td><td>185,000</td><td>No big dam before 1992 Main vegetation cover: grass and forest</td></tr><tr><td>Nam Muc Basin</td><td>1997–2006monthly</td><td>2,200</td><td>No big dam existedMain vegetation cover: forest</td></tr></table>
b7ecd8ec06c6043b3831ca71e2e5de4558a94ff33db4d7d9fb17ae39cd472d45.png
complex
<table><tr><td rowspan="3">Characteristic</td><td colspan="2">Public</td><td colspan="2">Private</td><td rowspan="3">p<sup>b</sup></td></tr><tr><td>n</td><td>%</td><td>n</td><td>%</td></tr><tr><td>Maternal age (years)</td><td colspan="5"> </td></tr><tr><td>12&#8211;19</td><td>1,487</td><td>19.7</td><td>128</td><td>5.7</td><td>&lt; 0.001</td></tr><tr><td>20&#8211;34</td><td>5,396</td><td>71.3</td><td>1,716</td><td>76.0</td><td> </td></tr><tr><td>35 or more</td><td>683</td><td>9.0</td><td>415</td><td>18.3</td><td> </td></tr><tr><td>Total</td><td>7,566<sup>a</sup></td><td>100</td><td>2,259</td><td>100</td><td> </td></tr><tr><td>Skin colour</td><td colspan="5"> </td></tr><tr><td>Indigenous</td><td>25</td><td>0.3</td><td>5</td><td>0.2</td><td>&lt; 0.001</td></tr><tr><td>Black</td><td>835</td><td>11.0</td><td>95</td><td>4.2</td><td> </td></tr><tr><td>Brown</td><td>4,139</td><td>54.8</td><td>835</td><td>36.9</td><td> </td></tr><tr><td>Oriental</td><td>83</td><td>1,1</td><td>30</td><td>1,3</td><td> </td></tr><tr><td>White</td><td>2,482</td><td>32,8</td><td>1,294</td><td>57.3</td><td> </td></tr><tr><td>Total</td><td>7,564<sup>a</sup></td><td>100</td><td>2,259</td><td>100</td><td> </td></tr><tr><td>Education</td><td colspan="5"> </td></tr><tr><td>Elementary school</td><td>4,172</td><td>55.3</td><td>330</td><td>14.7</td><td>&lt; 0.001</td></tr><tr><td>High school</td><td>3,153</td><td>41.8</td><td>1,265</td><td>56.4</td><td> </td></tr><tr><td>College or more</td><td>220</td><td>2.9</td><td>649</td><td>28.9</td><td> </td></tr><tr><td>otal</td><td>7,545<sup>a</sup></td><td>100</td><td>2,244<sup>a</sup></td><td>100</td><td> </td></tr><tr><td>Marital status</td><td colspan="5"> </td></tr><tr><td>With partner</td><td>5,734</td><td>75.8</td><td>1,990</td><td>88.2</td><td>&lt; 0.001</td></tr><tr><td>No partner</td><td>1,832</td><td>24.2</td><td>267</td><td>11.8</td><td> </td></tr><tr><td>Total</td><td>7,566<sup>a</sup></td><td>100</td><td>2,257<sup>a</sup></td><td>100</td><td> </td></tr><tr><td>Paid work</td><td colspan="5"> </td></tr><tr><td>No</td><td>4,790</td><td>63.3</td><td>674</td><td>29.8</td><td>&lt; 0.001</td></tr><tr><td>Yes</td><td>2,777</td><td>36.7</td><td>1,585</td><td>70.2</td><td> </td></tr><tr><td>Total</td><td>7,567<sup>a</sup></td><td>100</td><td>2,259</td><td>100</td><td> </td></tr><tr><td>Economic class</td><td colspan="5"> </td></tr><tr><td>A or B</td><td>1,376</td><td>18.3</td><td>1,416</td><td>63.5</td><td>&lt; 0.001</td></tr><tr><td>C</td><td>4,780</td><td>63.5</td><td>770</td><td>34.5</td><td> </td></tr><tr><td>D or E</td><td>1,372</td><td>18.2</td><td>45</td><td>2.0</td><td> </td></tr><tr><td>Total</td><td>7,528<sup>a</sup></td><td>100</td><td>2,231<sup>a</sup></td><td>100</td><td> </td></tr><tr><td>Hospital location</td><td colspan="5"> </td></tr><tr><td>Capital</td><td>2,507</td><td>33.1</td><td>766</td><td>33.9</td><td>0.486</td></tr><tr><td>Regional</td><td>5,062</td><td>66.9</td><td>1,493</td><td>66.1</td><td> </td></tr><tr><td>Total</td><td>7,569</td><td>100</td><td>2,259</td><td>100</td><td> </td></tr><tr><td>Previous cesarian section</td><td colspan="5"> </td></tr><tr><td>No</td><td>2,603</td><td>34.4</td><td>350</td><td>15.5</td><td>&lt; 0.001</td></tr><tr><td>Yes</td><td>1,608</td><td>21.2</td><td>653</td><td>28.9</td><td> </td></tr><tr><td>Primiparae</td><td>3,358</td><td>44.4</td><td>1,256</td><td>55.6</td><td> </td></tr><tr><td>Total</td><td>7,569</td><td>100</td><td>2,259</td><td>100</td><td> </td></tr><tr><td>Antenatal complications</td><td colspan="5"> </td></tr><tr><td>No</td><td>4,161</td><td>55.0</td><td>1,378</td><td>61.0</td><td>&lt; 0.001</td></tr><tr><td>Yes</td><td>3,408</td><td>45.0</td><td>881</td><td>39.0</td><td> </td></tr><tr><td>Total</td><td>7,569</td><td>100</td><td>2,259</td><td>100</td><td> </td></tr><tr><td>Labour complications</td><td colspan="5"> </td></tr><tr><td>No</td><td>2,312</td><td>30.5</td><td>675</td><td>29.9</td><td>0.016</td></tr><tr><td>Yes</td><td>1,419</td><td>18.7</td><td>372</td><td>16.5</td><td> </td></tr><tr><td>No labour</td><td>3,838</td><td>50.8</td><td>1,212</td><td>53.6</td><td> </td></tr><tr><td>otal</td><td>7,569</td><td>100</td><td>2,259</td><td>100</td><td> </td></tr></table>
<table><tr><td rowspan="3">Characteristic</td><td colspan="2">Public</td><td colspan="2">Private</td><td rowspan="3">pb</td></tr><tr><td>n</td><td>%</td><td>n</td><td>%</td></tr><tr><td colspan="4"></td></tr><tr><td>Maternal age (years)</td><td colspan="5"></td></tr><tr><td>12–19</td><td>1,487</td><td>19.7</td><td>128</td><td>5.7</td><td>< 0.001</td></tr><tr><td>20–34</td><td>5,396</td><td>71.3</td><td>1,716</td><td>76.0</td><td></td></tr><tr><td>35 or more</td><td>683</td><td>9.0</td><td>415</td><td>18.3</td><td></td></tr><tr><td>Total</td><td>7,566a</td><td>100</td><td>2,259</td><td>100</td><td></td></tr><tr><td>Skin colour</td><td colspan="5"></td></tr><tr><td>Indigenous</td><td>25</td><td>0.3</td><td>5</td><td>0.2</td><td>< 0.001</td></tr><tr><td>Black</td><td>835</td><td>11.0</td><td>95</td><td>4.2</td><td></td></tr><tr><td>Brown</td><td>4,139</td><td>54.8</td><td>835</td><td>36.9</td><td></td></tr><tr><td>Oriental</td><td>83</td><td>1,1</td><td>30</td><td>1,3</td><td></td></tr><tr><td>White</td><td>2,482</td><td>32,8</td><td>1,294</td><td>57.3</td><td></td></tr><tr><td>Total</td><td>7,564a</td><td>100</td><td>2,259</td><td>100</td><td></td></tr><tr><td>Education</td><td colspan="5"></td></tr><tr><td>Elementary school</td><td>4,172</td><td>55.3</td><td>330</td><td>14.7</td><td>< 0.001</td></tr><tr><td>High school</td><td>3,153</td><td>41.8</td><td>1,265</td><td>56.4</td><td></td></tr><tr><td>College or more</td><td>220</td><td>2.9</td><td>649</td><td>28.9</td><td></td></tr><tr><td>otal</td><td>7,545a</td><td>100</td><td>2,244a</td><td>100</td><td></td></tr><tr><td>Marital status</td><td colspan="5"></td></tr><tr><td>With partner</td><td>5,734</td><td>75.8</td><td>1,990</td><td>88.2</td><td>< 0.001</td></tr><tr><td>No partner</td><td>1,832</td><td>24.2</td><td>267</td><td>11.8</td><td></td></tr><tr><td>Total</td><td>7,566a</td><td>100</td><td>2,257a</td><td>100</td><td></td></tr><tr><td>Paid work</td><td colspan="5"></td></tr><tr><td>No</td><td>4,790</td><td>63.3</td><td>674</td><td>29.8</td><td>< 0.001</td></tr><tr><td>Yes</td><td>2,777</td><td>36.7</td><td>1,585</td><td>70.2</td><td></td></tr><tr><td>Total</td><td>7,567a</td><td>100</td><td>2,259</td><td>100</td><td></td></tr><tr><td>Economic class</td><td colspan="5"></td></tr><tr><td>A or B</td><td>1,376</td><td>18.3</td><td>1,416</td><td>63.5</td><td>< 0.001</td></tr><tr><td>C</td><td>4,780</td><td>63.5</td><td>770</td><td>34.5</td><td></td></tr><tr><td>D or E</td><td>1,372</td><td>18.2</td><td>45</td><td>2.0</td><td></td></tr><tr><td>Total</td><td>7,528a</td><td>100</td><td>2,231a</td><td>100</td><td></td></tr><tr><td>Hospital location</td><td colspan="5"></td></tr><tr><td>Capital</td><td>2,507</td><td>33.1</td><td>766</td><td>33.9</td><td>0.486</td></tr><tr><td>Regional</td><td>5,062</td><td>66.9</td><td>1,493</td><td>66.1</td><td></td></tr><tr><td>Total</td><td>7,569</td><td>100</td><td>2,259</td><td>100</td><td></td></tr><tr><td>Previous cesarian section</td><td colspan="5"></td></tr><tr><td>No</td><td>2,603</td><td>34.4</td><td>350</td><td>15.5</td><td>< 0.001</td></tr><tr><td>Yes</td><td>1,608</td><td>21.2</td><td>653</td><td>28.9</td><td></td></tr><tr><td>Primiparae</td><td>3,358</td><td>44.4</td><td>1,256</td><td>55.6</td><td></td></tr><tr><td>Total</td><td>7,569</td><td>100</td><td>2,259</td><td>100</td><td></td></tr><tr><td>Antenatal complications</td><td colspan="5"></td></tr><tr><td>No</td><td>4,161</td><td>55.0</td><td>1,378</td><td>61.0</td><td>< 0.001</td></tr><tr><td>Yes</td><td>3,408</td><td>45.0</td><td>881</td><td>39.0</td><td></td></tr><tr><td>Total</td><td>7,569</td><td>100</td><td>2,259</td><td>100</td><td></td></tr><tr><td>Labour complications</td><td colspan="5"></td></tr><tr><td>No</td><td>2,312</td><td>30.5</td><td>675</td><td>29.9</td><td>0.016</td></tr><tr><td>Yes</td><td>1,419</td><td>18.7</td><td>372</td><td>16.5</td><td></td></tr><tr><td>No labo</td><td>3</td><td>50.</td><td>1,2</td><td>53.</td><td></td></tr></table>
<table><tr><td rowspan="3">Characteristic</td><td colspan="2">Public</td><td colspan="2">Private</td></tr><tr><td>n</td><td>%</td><td>n</td><td>%</td></tr><tr><td colspan="4"></td></tr><tr><td>ur</td><td>,838</td><td>8</td><td>12</td><td>6</td></tr><tr><td>otal</td><td>7,569</td><td>100</td><td>2,259</td><td>100</td></tr></table>
f524114ccd3d72275ddfcc7f1ee85046e7a428d1a36020a9d6a22008876bb75d.png
complex
<table><tr><td rowspan="3">Variable</td><td colspan="2">2 year</td><td colspan="2">3 year</td><td colspan="2">5 year</td><td colspan="2">10 year</td></tr><tr><td>Univariate</td><td>Multivariate</td><td>Univariate</td><td>Multivariate</td><td>Univariate</td><td>Multivariate</td><td>Univariate</td><td>Multivariate</td></tr><tr><td>HR (95% C.I)</td><td>HR (95% C.I)</td><td>HR (95% C.I)</td><td>HR (95% C.I)</td><td>HR (95% C.I)</td><td>HR (95% C.I)</td><td>HR (95% C.I)</td><td>HR (95% C.I)</td></tr><tr><td>Hb trajectory</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Normal Hb</td><td>Ref.</td><td>Ref.</td><td>Ref.</td><td>Ref.</td><td>Ref.</td><td>Ref.</td><td>Ref.</td><td>Ref.</td></tr><tr><td>Persisted anemia</td><td>7.8(2.9-21.1)**</td><td>3.4(1.2-10.2)*</td><td>5.6(2.8-11.3)**</td><td>2.9(1.3-6.2)*</td><td>4.9(2.9-8.3)**</td><td>2.4(1.3-4.3)*</td><td>4.2(2.6-6.7)**</td><td>2.2(1.3-3.8)*</td></tr><tr><td>Improved anemia</td><td>4.0(1.2-13.2)*</td><td>2.1(0.5-8.8)</td><td>2.5(1.0-6.1)</td><td>1.6(0.5-4.5)</td><td>2.7(1.4-5.3)*</td><td>2.0(0.9-4.2)</td><td>2.2(1.2-4.0)*</td><td>1.8(0.9-3.5)</td></tr><tr><td>Mild anemia</td><td>2.5(0.9-6.6)</td><td>1.5(0.6-4.1)</td><td>1.9(1.0-3.8)*</td><td>1.2(0.60-2.5)</td><td>1.7(0.9-2.7)</td><td>1.0(0.6-1.8)</td><td>1.6(1.0-2.5)*</td><td>1.1(0.7-1.7)</td></tr><tr><td>Low normal Hb</td><td>1.9(0.8-4.8)</td><td>1.3(0.5-3.4)</td><td>1.5(0.8-2.8)</td><td>1.1(0.6-2.1)</td><td>1.5(0.9-2.3)</td><td>1.0(0.6-1.6)</td><td>1.3(0.9-2.0)</td><td>1.1(0.7-1.6)</td></tr></table>
<table><tr><td rowspan="3">Variable</td><td colspan="2">2 year</td><td colspan="2">3 year</td><td colspan="2">5 year</td><td colspan="2">10 year</td></tr><tr><td>Univariate</td><td>Multivariate</td><td>Univariate</td><td>Multivariate</td><td>Univariate</td><td>Multivariate</td><td>Univariate</td><td>Multivariate</td></tr><tr><td>HR (95% C.I)</td><td>HR (95% C.I)</td><td>HR (95% C.I)</td><td>HR (95% C.I)</td><td>HR (95% C.I)</td><td>HR (95% C.I)</td><td>HR (95% C.I)</td><td>HR (95% C.I)</td></tr><tr><td>Hb trajectory</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr></table>
<table><tr><td rowspan="3">Variable</td><td colspan="2">2 year</td><td colspan="2">3 year</td><td colspan="2">5 year</td><td colspan="2">10 year</td></tr><tr><td>Univariate</td><td>Multivariate</td><td>Univariate</td><td>Multivariate</td><td>Univariate</td><td>Multivariate</td><td>Univariate</td><td>Multivariate</td></tr><tr><td>HR (95% C.I)</td><td>HR (95% C.I)</td><td>HR (95% C.I)</td><td>HR (95% C.I)</td><td>HR (95% C.I)</td><td>HR (95% C.I)</td><td>HR (95% C.I)</td><td>HR (95% C.I)</td></tr><tr><td>Normal Hb</td><td>Ref.</td><td>Ref.</td><td>Ref.</td><td>Ref.</td><td>Ref.</td><td>Ref.</td><td>Ref.</td><td>Ref.</td></tr><tr><td>Persisted anemia</td><td>7.8(2.9-21.1)**</td><td>3.4(1.2-10.2)*</td><td>5.6(2.8-11.3)**</td><td>2.9(1.3-6.2)*</td><td>4.9(2.9-8.3)**</td><td>2.4(1.3-4.3)*</td><td>4.2(2.6-6.7)**</td><td>2.2(1.3-3.8)*</td></tr><tr><td>Improved anemia</td><td>4.0(1.2-13.2)*</td><td>2.1(0.5-8.8)</td><td>2.5(1.0-6.1)</td><td>1.6(0.5-4.5)</td><td>2.7(1.4-5.3)*</td><td>2.0(0.9-4.2)</td><td>2.2(1.2-4.0)*</td><td>1.8(0.9-3.5)</td></tr><tr><td>Mild anemia</td><td>2.5(0.9-6.6)</td><td>1.5(0.6-4.1)</td><td>1.9(1.0-3.8)*</td><td>1.2(0.60-2.5)</td><td>1.7(0.9-2.7)</td><td>1.0(0.6-1.8)</td><td>1.6(1.0-2.5)*</td><td>1.1(0.7-1.7)</td></tr><tr><td>Low normal Hb</td><td>1.9(0.8-4.8)</td><td>1.3(0.5-3.4)</td><td>1.5(0.8-2.8)</td><td>1.1(0.6-2.1)</td><td>1.5(0.9-2.3)</td><td>1.0(0.6-1.6)</td><td>1.3(0.9-2.0)</td><td>1.1(0.7-1.6)</td></tr></table>
5d8693dc9a2d2f740231697d5955c6cd9962ca1fe8397232befa726caaa5a57c.png
complex
<table><tr><td> </td><td> </td><td>Control group (<i>n</i> = 26)</td><td>UTI group (<i>n</i> = 24)</td><td><i>P</i></td></tr><tr><td rowspan="2">FDP (<i>&#956;</i>g/ml)</td><td>BOD</td><td>1.76 &#177; 1.11</td><td>1.84 &#177; 1.70</td><td>0.854</td></tr><tr><td>POD1</td><td>6.87 &#177; 5.19</td><td>5.04 &#177; 2.63</td><td>0.142</td></tr><tr><td rowspan="2">Fbg (mg/dl)</td><td>BOD</td><td>307.30 &#177; 118.49</td><td>278.15 &#177; 78.01</td><td>0.314</td></tr><tr><td>POD1</td><td>329.64 &#177; 125.57</td><td>294.70 &#177; 80.56</td><td>0.252</td></tr><tr><td rowspan="2">D-dimer (mg/L)</td><td>BOD</td><td>0.36 &#177; 0.42</td><td>0.37 &#177; 0.64</td><td>0.963</td></tr><tr><td>POD1</td><td>2.30 &#177; 1.96</td><td>1.57 &#177; 1.08</td><td>0.128</td></tr><tr><td rowspan="2">INR</td><td>BOD</td><td>1.02 &#177; 0.08</td><td>1.01 &#177; 0.67</td><td>0.778</td></tr><tr><td>POD1</td><td>1.08 &#177; 0.11</td><td>1.11 &#177; 0.08</td><td>0.290</td></tr></table>
<table><tr><td></td><td></td></tr><tr><td rowspan="2">FDP (ΞΌg/ml)</td><td>BOD</td></tr><tr><td>POD1</td></tr><tr><td rowspan="2">Fbg (mg/dl)</td><td>BOD</td></tr><tr><td>POD1</td></tr><tr><td rowspan="2">D-dimer (mg/L)</td><td>BOD</td></tr><tr><td>POD1</td></tr><tr><td rowspan="2">INR</td><td>BOD</td></tr><tr><td>POD1</td></tr></table>
<table><tr><td>Control group (n = 26)</td><td>UTI group (n = 24)</td><td>P</td></tr><tr><td>1.76 Β± 1.11</td><td>1.84 Β± 1.70</td><td>0.854</td></tr><tr><td>6.87 Β± 5.19</td><td>5.04 Β± 2.63</td><td>0.142</td></tr><tr><td>307.30 Β± 118.49</td><td>278.15 Β± 78.01</td><td>0.314</td></tr><tr><td>329.64 Β± 125.57</td><td>294.70 Β± 80.56</td><td>0.252</td></tr><tr><td>0.36 Β± 0.42</td><td>0.37 Β± 0.64</td><td>0.963</td></tr><tr><td>2.30 Β± 1.96</td><td>1.57 Β± 1.08</td><td>0.128</td></tr><tr><td>1.02 Β± 0.08</td><td>1.01 Β± 0.67</td><td>0.778</td></tr><tr><td>1.08 Β± 0.11</td><td>1.11 Β± 0.08</td><td>0.290</td></tr></table>
11caee0c0c3e977c9dfca9e6992c5153275d519b51cce4038a0426435ca8b565.png
simple
<table><tr><td>Libraries</td><td>LS1 mean</td><td>Nb. of concordant identifications</td><td>LS1 mean of concordant identifications</td><td>Nb. of non-concordant identifications</td><td>LS1 mean of non -concordant identifications</td><td>Mean of the difference between LS1 and LS2</td><td>Max frequency parameter (%)</td><td>Nb. of peaks parameter</td></tr><tr><td>B1</td><td>1.34</td><td>449</td><td>1.58</td><td>361</td><td>1.04</td><td>0.38</td><td>25</td><td>70</td></tr><tr><td>B1b</td><td>1.34</td><td>449</td><td>1.58</td><td>361</td><td>1.04</td><td>0.38</td><td>25</td><td>100</td></tr><tr><td>B1c</td><td>1.34</td><td>449</td><td>1.58</td><td>361</td><td>1.04</td><td>0.38</td><td>50</td><td>70</td></tr><tr><td>B1d</td><td>1.36</td><td>473</td><td>1.60</td><td>337</td><td>1.03</td><td>0.40</td><td>50</td><td>100</td></tr><tr><td>B1e</td><td>1.34</td><td>449</td><td>1.58</td><td>361</td><td>1.04</td><td>0.38</td><td>75</td><td>70</td></tr><tr><td>B1f</td><td>1.32</td><td>445</td><td>1.56</td><td>365</td><td>1.03</td><td>0.36</td><td>75</td><td>100</td></tr><tr><td>B1g</td><td>1.39</td><td>473</td><td>1.63</td><td>337</td><td>1.05</td><td>0.43</td><td>100</td><td>70</td></tr><tr><td>B1h</td><td>1.39</td><td>473</td><td>1.63</td><td>337</td><td>1.05</td><td>0.43</td><td>100</td><td>100</td></tr><tr><td>B7</td><td>1.80</td><td>611</td><td>1.96</td><td>199</td><td>1.30</td><td>0.53</td><td>25</td><td>70</td></tr><tr><td>B7g</td><td>1.80</td><td>595</td><td>1.96</td><td>215</td><td>1.35</td><td>0.50</td><td>100</td><td>70</td></tr></table>
<table><tr><td>Libraries</td><td>LS1 mean</td><td>Nb. of concordant identifications</td><td>LS1 mean of concordant identifications</td><td>Nb. of non-concordant identifications</td><td>LS1 mean of non -concordant identifications</td><td>Mean of the difference between LS1 and LS2</td><td>Max frequency parameter (%)</td><td>Nb. of peaks parameter</td></tr><tr><td>B1</td><td>1.34</td><td>449</td><td>1.58</td><td>361</td><td>1.04</td><td>0.38</td><td>25</td><td>70</td></tr><tr><td>B1b</td><td>1.34</td><td>449</td><td>1.58</td><td>361</td><td>1.04</td><td>0.38</td><td>25</td><td>100</td></tr><tr><td>B1c</td><td>1.34</td><td>449</td><td>1.58</td><td>361</td><td>1.04</td><td>0.38</td><td>50</td><td>70</td></tr><tr><td>B1d</td><td>1.36</td><td>473</td><td>1.60</td><td>337</td><td>1.03</td><td>0.40</td><td>50</td><td>100</td></tr><tr><td>B1e</td><td>1.34</td><td>449</td><td>1.58</td><td>361</td><td>1.04</td><td>0.38</td><td>75</td><td>70</td></tr><tr><td>B1f</td><td>1.32</td><td>445</td><td>1.56</td><td>365</td><td>1.03</td><td>0.36</td><td>75</td><td>100</td></tr></table>
<table><tr><td>B1g</td><td>1.39</td><td>473</td><td>1.63</td><td>337</td><td>1.05</td><td>0.43</td><td>100</td><td>70</td></tr><tr><td>B1h</td><td>1.39</td><td>473</td><td>1.63</td><td>337</td><td>1.05</td><td>0.43</td><td>100</td><td>100</td></tr><tr><td>B7</td><td>1.80</td><td>611</td><td>1.96</td><td>199</td><td>1.30</td><td>0.53</td><td>25</td><td>70</td></tr><tr><td>B7g</td><td>1.80</td><td>595</td><td>1.96</td><td>215</td><td>1.35</td><td>0.50</td><td>100</td><td>70</td></tr></table>
83d6ee0ae465659d379981cec6236c199e216c3680d27193664d40eaeecee9b3.png
complex
<table><tr><td>Months</td><td>sAPP&#946;</td><td>APP 110 kDa</td><td>Serotonin</td></tr><tr><td colspan="4">7</td></tr><tr><td> WT</td><td>3780 &#177; 330 (5)-</td><td>99 &#177; 8 (5)-</td><td>59 &#177; 11 (5)-</td></tr><tr><td> WT Chol</td><td>3600 &#177; 330 (5) ns</td><td>80 &#177; 8 (5) ns</td><td>62 &#177; 11 (4) ns</td></tr><tr><td colspan="4">14</td></tr><tr><td> WT</td><td>3809 &#177; 332 (5)</td><td>146 &#177; 16 (5)-</td><td>70 &#177; 8 (5)-</td></tr><tr><td> WT Chol</td><td>2097 &#177; 909 (4) ns</td><td>180 &#177; 29 (5) ns</td><td>58 &#177; 15 (5) ns</td></tr><tr><td colspan="4">20</td></tr><tr><td> WT</td><td>2077 &#177; 464 (4)</td><td>76 &#177; 18 (6)</td><td>640 &#177; 127 (5)-</td></tr><tr><td> WT Chol</td><td>868 &#177; 396 (4) p = 0.09</td><td>105 &#177; 33 (5) ns</td><td>529 &#177; 163 (5) ns</td></tr></table>
<table><tr><td>Months</td><td>sAPPΞ²</td><td>APP 110 kDa</td><td>Serotonin</td></tr><tr><td colspan="4">7</td></tr><tr><td>WT</td><td>3780 Β± 330 (5)-</td><td>99 Β± 8 (5)-</td><td>59 Β± 11 (5)-</td></tr><tr><td>WT Chol</td><td>3600 Β± 330 (5) ns</td><td>80 Β± 8 (5) ns</td><td>62 Β± 11 (4) ns</td></tr><tr><td colspan="4">14</td></tr><tr><td>WT</td><td>3809 Β± 332 (5)</td><td>146 Β± 16 (5)-</td><td>70 Β± 8 (5)-</td></tr></table>
<table><tr><td>Months</td><td>sAPPΞ²</td><td>APP 110 kDa</td><td>Serotonin</td></tr><tr><td>WT Chol</td><td>2097 Β± 909 (4) ns</td><td>180 Β± 29 (5) ns</td><td>58 Β± 15 (5) ns</td></tr><tr><td colspan="4">20</td></tr><tr><td>WT</td><td>2077 Β± 464 (4)</td><td>76 Β± 18 (6)</td><td>640 Β± 127 (5)-</td></tr><tr><td>WT Chol</td><td>868 Β± 396 (4) p = 0.09</td><td>105 Β± 33 (5) ns</td><td>529 Β± 163 (5) ns</td></tr></table>
b03f693254710b2d5396ceed8641867bfcce89b4e13d0b359d0caa4b77fd6a0c.png
simple
<table><tr><td>Symptom</td><td>Median (IQR)</td><td>Rank</td><td>Low (score 1&#8211;3) N (%)</td><td>Medium (score 4&#8211;7) N (%)</td><td>High (score 8&#8211;10) N (%)</td></tr><tr><td>Weight gain</td><td>9 (6&#8211;10)</td><td>1</td><td>74 (12.3)</td><td>145 (24)</td><td>385 (63.7)</td></tr><tr><td>Insomnia</td><td>8 (5&#8211;10)</td><td>2</td><td>75 (12.4)</td><td>210 (34.8)</td><td>319 (52.8)</td></tr><tr><td>Moon face</td><td>8 (5&#8211;10)</td><td>2</td><td>125 (20.7)</td><td>149 (24.7)</td><td>330 (54.6)</td></tr><tr><td>High blood pressure</td><td>8 (4&#8211;10)</td><td>4</td><td>150 (24.8)</td><td>138 (22.8)</td><td>316 (52.3)</td></tr><tr><td>Reduced bone strength</td><td>8 (4&#8211;10)</td><td>4</td><td>133 (22)</td><td>134 (22.2)</td><td>337 (55.8)</td></tr><tr><td>Eye disease</td><td>8 (3&#8211;10)</td><td>6</td><td>164 (27.2)</td><td>93 (15.4)</td><td>347 (57.5)</td></tr><tr><td>Cardiovascular disease</td><td>8 (1&#8211;10)</td><td>7</td><td>216 (35.8)</td><td>56 (9.3)</td><td>332 (55)</td></tr><tr><td>Diabetes</td><td>8 (1&#8211;10)</td><td>7</td><td>206 (34.1)</td><td>86 (14.2)</td><td>312 (51.7)</td></tr><tr><td>Infections</td><td>8 (1&#8211;10)</td><td>7</td><td>182 (30.1)</td><td>116 (19.2)</td><td>306 (50.7)</td></tr><tr><td>Changes in mood</td><td>7 (5&#8211;9)</td><td>10</td><td>110 (18.2)</td><td>239 (39.6)</td><td>255 (42.2)</td></tr><tr><td>Skin changes</td><td>7 (5&#8211;9)</td><td>10</td><td>109 (18)</td><td>214 (35.4)</td><td>281 (46.5)</td></tr><tr><td>Palpitations</td><td>7 (4&#8211;9)</td><td>12</td><td>125 (20.7)</td><td>212 (35.1)</td><td>267 (44.2)</td></tr><tr><td>Indigestion</td><td>6 (3&#8211;8)</td><td>13</td><td>152 (25.2)</td><td>276 (45.7)</td><td>176 (29.1)</td></tr><tr><td>Acne</td><td>1 (1&#8211;6)</td><td>14</td><td>359 (59.4)</td><td>138 (22.8)</td><td>107 (17.7)</td></tr></table>
<table><tr><td>Symptom</td><td>Median (IQR)</td><td>Rank</td><td>Low (score 1–3) N (%)</td><td>Medium (score 4–7) N (%)</td><td>High (score 8–10) N (%)</td></tr><tr><td>Weight gain</td><td>9 (6–10)</td><td>1</td><td>74 (12.3)</td><td>145 (24)</td><td>385 (63.7)</td></tr><tr><td>Insomnia</td><td>8 (5–10)</td><td>2</td><td>75 (12.4)</td><td>210 (34.8)</td><td>319 (52.8)</td></tr><tr><td>Moon face</td><td>8 (5–10)</td><td>2</td><td>125 (20.7)</td><td>149 (24.7)</td><td>330 (54.6)</td></tr><tr><td>High blood</td><td>8 (4–</td><td></td><td>150 (24.8)</td><td>1</td><td>316</td></tr></table>
<table><tr><td>Symptom</td><td>Median (IQR)</td><td>Rank</td><td>Low (score 1–3) N (%)</td><td>Medium (score 4–7) N (%)</td><td>High (score 8–10) N (%)</td></tr><tr><td> pressure</td><td>10)</td><td>4</td><td></td><td>38 (22.8)</td><td> (52.3)</td></tr><tr><td>Reduced bone strength</td><td>8 (4–10)</td><td>4</td><td>133 (22)</td><td>134 (22.2)</td><td>337 (55.8)</td></tr><tr><td>Eye disease</td><td>8 (3–10)</td><td>6</td><td>164 (27.2)</td><td>93 (15.4)</td><td>347 (57.5)</td></tr><tr><td>Cardiovascular disease</td><td>8 (1–10)</td><td>7</td><td>216 (35.8)</td><td>56 (9.3)</td><td>332 (55)</td></tr><tr><td>Diabetes</td><td>8 (1–10)</td><td>7</td><td>206 (34.1)</td><td>86 (14.2)</td><td>312 (51.7)</td></tr><tr><td>Infections</td><td>8 (1–10)</td><td>7</td><td>182 (30.1)</td><td>116 (19.2)</td><td>306 (50.7)</td></tr><tr><td>Changes in mood</td><td>7 (5–9)</td><td>10</td><td>110 (18.2)</td><td>239 (39.6)</td><td>255 (42.2)</td></tr><tr><td>Skin changes</td><td>7 (5–9)</td><td>10</td><td>109 (18)</td><td>214 (35.4)</td><td>281 (46.5)</td></tr><tr><td>Palpitations</td><td>7 (4–9)</td><td>12</td><td>125 (20.7)</td><td>212 (35.1)</td><td>267 (44.2)</td></tr><tr><td>Indigestion</td><td>6 (3–8)</td><td>13</td><td>152 (25.2)</td><td>276 (45.7)</td><td>176 (29.1)</td></tr><tr><td>Acne</td><td>1 (1–6)</td><td>14</td><td>359 (59.4)</td><td>138 (22.8)</td><td>107 (17.7)</td></tr></table>
daafc7f86c1e350f2a87df00efeee2002e7131ededbf7904688daa15aa415f22.png
complex
<table><tr><td>Couple no.</td><td colspan="5">Females</td><td colspan="4">Males</td><td></td></tr><tr><td></td><td>Visits to ANC<sup>1</sup></td><td>Visits to CHC<sup>2</sup></td><td>Participation in childbirth and parenthood classes</td><td>Visit to dental hygienist during pregnancy</td><td>Ever visited open pre-school</td><td>Visits to ANC</td><td>Visits to CHC</td><td>Participation in childbirth and parenthood classes</td><td>Visit to dental hygienist during pregnancy</td><td>Ever visited open pre-school</td></tr><tr><td>1</td><td>Most visits</td><td>Most visits</td><td>ANC and CHC</td><td>No</td><td>Yes</td><td>Most visits</td><td>Sometimes</td><td>Only ANC</td><td>No</td><td>Yes</td></tr><tr><td>2</td><td>Most visits</td><td>Most visits</td><td>Only ANC</td><td>No</td><td>Yes</td><td>Most visits</td><td>Sometimes</td><td>Only ANC</td><td>No</td><td>Yes</td></tr><tr><td>3</td><td>Most visits</td><td>Most visits</td><td>Only CHC</td><td>No</td><td>Yes</td><td>Most visits</td><td>Most visits</td><td>No</td><td>No</td><td>Yes</td></tr><tr><td>4</td><td>Most visits</td><td>Most visits</td><td>ANC and CHC</td><td>Yes</td><td>Yes</td><td>Most visits</td><td>Most visits</td><td>Only ANC</td><td>Yes</td><td>No</td></tr><tr><td>5</td><td>Most visits</td><td>Most visits</td><td>Only ANC</td><td>Yes</td><td>Yes</td><td>Most visits</td><td>Most visits</td><td>Only ANC</td><td>Yes</td><td>Yes</td></tr><tr><td>6</td><td>Most visits</td><td>Most visits</td><td>Only CHC</td><td>No</td><td>Yes</td><td>Most visits</td><td>Most visits</td><td>Only CHC</td><td>No</td><td>Yes</td></tr><tr><td>7</td><td>Most visits</td><td>Most visits</td><td>Only ANC</td><td>No</td><td>Yes</td><td>Sometimes</td><td>Seldom</td><td>Only ANC</td><td>No</td><td>No</td></tr><tr><td>8</td><td>Most visits</td><td>Most visits</td><td>Only ANC</td><td>No</td><td>Yes</td><td>Sometimes</td><td>Sometimes</td><td>Only ANC</td><td>No</td><td>Yes</td></tr><tr><td>9</td><td>Most visits</td><td>Most visits</td><td>ANC and CHC</td><td>No</td><td>Yes</td><td>Most visits</td><td>Most visits</td><td>ANC and CHC</td><td>No</td><td>Yes</td></tr><tr><td>10</td><td>Most visits</td><td>Most visits</td><td>Only ANC</td><td>No</td><td>No</td><td>Most visits</td><td>Most visits</td><td>Only ANC</td><td>No</td><td>No</td></tr><tr><td>11</td><td>Most visits</td><td>Most visits</td><td>ANC and CHC</td><td>No</td><td>Yes</td><td>Sometimes</td><td>Sometimes</td><td>ANC and CHC</td><td>No</td><td>Yes</td></tr><tr><td>12</td><td>Most visits</td><td>Most visits</td><td>Only ANC</td><td>Yes</td><td>Yes</td><td>Seldom</td><td>Seldom</td><td>ANC (once)</td><td>No</td><td>Yes</td></tr></table>
<table><tr><td>Couple no.</td><td colspan="5">Females</td><td colspan="4">Males</td><td></td></tr><tr><td></td><td>Visits to ANC1</td><td>Visits to CHC2</td><td>Participation in childbirth and parenthood classes</td><td>Visit to dental hygienist during pregnancy</td><td>Ever visited open pre-school</td><td>Visits to ANC</td><td>Visits to CHC</td><td>Participation in childbirth and parenthood classes</td><td>Visit to dental hygienist during pregnancy</td><td>Ever visited open pre-school</td></tr><tr><td>1</td><td>Most visits</td><td>Most visits</td><td>ANC and CHC</td><td>No</td><td>Yes</td><td>Most visits</td><td>Sometimes</td><td>Only ANC</td><td>No</td><td>Yes</td></tr><tr><td>2</td><td>Most visits</td><td>Most visits</td><td>Only ANC</td><td>No</td><td>Yes</td><td>Most visits</td><td>Sometimes</td><td>Only ANC</td><td>No</td><td>Yes</td></tr><tr><td>3</td><td>Most visits</td><td>Most visits</td><td>Only CHC</td><td>No</td><td>Yes</td><td>Most visits</td><td>Most visits</td><td>No</td><td>No</td><td>Yes</td></tr><tr><td>4</td><td>Most visits</td><td>Most visits</td><td>ANC and CHC</td><td>Yes</td><td>Yes</td><td>Most visits</td><td>Most visits</td><td>Only ANC</td><td>Yes</td><td>No</td></tr><tr><td>5</td><td>Most visits</td><td>Most visits</td><td>Only ANC</td><td>Yes</td><td>Yes</td><td>Most visits</td><td>Most visits</td><td>Only ANC</td><td>Yes</td><td>Yes</td></tr><tr><td>6</td><td>Most visits</td><td>Most visits</td><td>Only CHC</td><td>No</td><td>Yes</td><td>Most visits</td><td>Most visits</td><td>Only CHC</td><td>No</td><td>Yes</td></tr></table>
<table><tr><td>Couple no.</td><td colspan="5">Females</td><td colspan="4">Males</td><td></td></tr><tr><td></td><td>Visits to ANC1</td><td>Visits to CHC2</td><td>Participation in childbirth and parenthood classes</td><td>Visit to dental hygienist during pregnancy</td><td>Ever visited open pre-school</td><td>Visits to ANC</td><td>Visits to CHC</td><td>Participation in childbirth and parenthood classes</td><td>Visit to dental hygienist during pregnancy</td><td>Ever visited open pre-school</td></tr><tr><td>7</td><td>Most visits</td><td>Most visits</td><td>Only ANC</td><td>No</td><td>Yes</td><td>Sometimes</td><td>Seldom</td><td>Only ANC</td><td>No</td><td>No</td></tr><tr><td>8</td><td>Most visits</td><td>Most visits</td><td>Only ANC</td><td>No</td><td>Yes</td><td>Sometimes</td><td>Sometimes</td><td>Only ANC</td><td>No</td><td>Yes</td></tr><tr><td>9</td><td>Most visits</td><td>Most visits</td><td>ANC and CHC</td><td>No</td><td>Yes</td><td>Most visits</td><td>Most visits</td><td>ANC and CHC</td><td>No</td><td>Yes</td></tr><tr><td>10</td><td>Most visits</td><td>Most visits</td><td>Only ANC</td><td>No</td><td>No</td><td>Most visits</td><td>Most visits</td><td>Only ANC</td><td>No</td><td>No</td></tr><tr><td>11</td><td>Most visits</td><td>Most visits</td><td>ANC and CHC</td><td>No</td><td>Yes</td><td>Sometimes</td><td>Sometimes</td><td>ANC and CHC</td><td>No</td><td>Yes</td></tr><tr><td>12</td><td>Most visits</td><td>Most visits</td><td>Only ANC</td><td>Yes</td><td>Yes</td><td>Seldom</td><td>Seldom</td><td>ANC (once)</td><td>No</td><td>Yes</td></tr></table>
55044837b1f137dfa7163d2f92f7d411a5aab31cb86005f6ebf63256080fb031.png
simple
<table><tr><td></td><td>Total</td><td><i>sea</i></td><td><i>seb</i></td><td><i>sec</i></td><td><i>sed</i></td><td><i>see</i></td><td><i>seg</i></td><td><i>seh</i></td><td><i>sei</i></td><td><i>selj</i></td><td><i>sek</i></td><td><i>sell</i></td><td><i>sem</i></td><td><i>sen</i></td><td><i>seo</i></td><td><i>sep</i></td><td><i>seq</i></td><td><i>ser</i></td><td><i>tsst&#8208;1</i></td></tr><tr><td>Shopping baskets (<i>n</i> = 740)</td><td>46</td><td>2</td><td>5</td><td>&#8211;</td><td>&#8211;</td><td>&#8211;</td><td>14</td><td>1</td><td>8</td><td>&#8211;</td><td>1</td><td>3</td><td>6</td><td>12</td><td>10</td><td>6</td><td>&#8211;</td><td>&#8211;</td><td>8</td></tr><tr><td>Percentage</td><td></td><td>4.3</td><td>10.9</td><td>&#8211;</td><td>&#8211;</td><td>&#8211;</td><td>30.4</td><td>2.2</td><td>17.4</td><td>&#8211;</td><td>2.2</td><td>6.5</td><td>13.0</td><td>26.1</td><td>21.7</td><td>13.0</td><td>&#8211;</td><td>&#8211;</td><td>17.4</td></tr></table>
<table><tr><td></td><td>Total</td><td>sea</td><td>seb</td><td>sec</td><td>sed</td><td>see</td><td>seg</td><td>seh</td><td>sei</td><td>selj</td><td>sek</td><td>sell</td><td>sem</td><td>sen</td><td>seo</td><td>sep</td><td>seq</td><td>ser</td><td>tsst‐1</td></tr><tr><td>Shopping bask</td><td>46</td><td></td><td></td><td></td><td></td><td></td><td>1</td><td></td><td></td><td></td><td>1</td><td>3</td><td>6</td><td>12</td><td>10</td><td>6</td><td></td><td></td><td>8</td></tr></table>
<table><tr><td>ets (n = 740)</td><td></td><td>2</td><td>5</td><td>–</td><td>–</td><td>–</td><td>4</td><td>1</td><td>8</td><td>–</td><td></td><td></td><td></td><td></td><td></td><td></td><td>–</td><td>–</td><td></td></tr><tr><td>Percentage</td><td></td><td>4.3</td><td>10.9</td><td>–</td><td>–</td><td>–</td><td>30.4</td><td>2.2</td><td>17.4</td><td>–</td><td>2.2</td><td>6.5</td><td>13.0</td><td>26.1</td><td>21.7</td><td>13.0</td><td>–</td><td>–</td><td>17.4</td></tr></table>
088669846884a6ea6a3449bad1be0e55e7a1ff9bd66ff06c0bb59ddf36baac03.png
complex
<table><tr><td></td><td></td><td colspan="3">Admission appropriateness</td><td colspan="3">Length of stay appropriateness</td></tr><tr><td></td><td></td><td>Yes</td><td>No</td><td>P Value</td><td>Yes</td><td>No</td><td>P Value</td></tr><tr><td></td><td></td><td>% (n)</td><td>% (n)</td><td></td><td>% (n)</td><td>% (n)</td><td></td></tr><tr><td>Gender</td><td>Female</td><td>70.7 (41)</td><td>29.3 (17)</td><td>0.678</td><td>37.5 (15)</td><td>62.5 (25)</td><td>0.932</td></tr><tr><td></td><td>Male</td><td>74.1 (43)</td><td>25.9 (15)</td><td></td><td>36.6 (15)</td><td>63.4 (26)</td><td></td></tr><tr><td>Admitted via the emergency department?</td><td>Yes</td><td>68.1 (47)</td><td>31.9 (22)</td><td>0.210</td><td>40.0 (18)</td><td>60.0 (27)</td><td>0.537</td></tr><tr><td></td><td>No</td><td>78.7 (37)</td><td>21.3 (10)</td><td></td><td>33.3 (12)</td><td>66.7 (24)</td><td></td></tr><tr><td>Presented with a neurologically related problem?</td><td>Yes</td><td>64.3 (27)</td><td>35.7 (15)</td><td>0.315</td><td>34.6 (9)</td><td>65.4 (17)</td><td>0.343</td></tr><tr><td></td><td>No</td><td>73.7 (42)</td><td>26.3 (15)</td><td></td><td>46.3 (19)</td><td>53.7 (22)</td><td></td></tr><tr><td>Place of residence</td><td>Nursing/residential home</td><td>88.0 (22)</td><td>12.0 (3)</td><td>0.049*</td><td>33.7 (7)</td><td>66.7 (14)</td><td>0.683</td></tr><tr><td></td><td>Own home</td><td>68.1 (62)</td><td>31.9 (29)</td><td></td><td>38.3 (23)</td><td>61.7 (37)</td><td></td></tr><tr><td>Household members</td><td>Lives with others</td><td>69.4 (43)</td><td>30.6 (19)</td><td>0.795</td><td>54.8 (23)</td><td>45.2 (19)</td><td>&lt; 0.001*</td></tr><tr><td></td><td>Lives alone</td><td>66.7 (20)</td><td>33.3 (10)</td><td></td><td>5.3 (1)</td><td>94.7 (18)</td><td></td></tr><tr><td>Receives home help</td><td>Yes</td><td>74.3 (26)</td><td>25.7 (9)</td><td>0.262</td><td>25.0 (6)</td><td>75.0 (18)</td><td>0.058</td></tr><tr><td></td><td>No</td><td>62.7 (32)</td><td>37.3 (19)</td><td></td><td>50.0 (16)</td><td>50.0 (16)</td><td></td></tr><tr><td>Referred to in-patient physiotherapy</td><td>Yes</td><td>n/a</td><td>n/a</td><td>n/a</td><td>25.0 (10)</td><td>75.0 (30)</td><td>0.027*</td></tr><tr><td></td><td>No</td><td></td><td></td><td></td><td>48.8 (20)</td><td>51.2 (21)</td><td></td></tr><tr><td>Referred to social services</td><td>Yes</td><td>n/a</td><td>n/a</td><td>n/a</td><td>9.1 (1)</td><td>90.9 (10)</td><td>0.039*</td></tr><tr><td></td><td>No</td><td></td><td></td><td></td><td>41.4 (29)</td><td>58.6 (41)</td><td></td></tr><tr><td>Transferred on discharge</td><td>Yes</td><td>74.2 (66)</td><td>235.8 (23)</td><td>0.155</td><td>18.2 (2)</td><td>81.8 (9)</td><td>0.164</td></tr><tr><td></td><td>No</td><td>57.0 (11)</td><td>42.1 (8)</td><td></td><td>40.0 (28)</td><td>60.0 (42)</td><td></td></tr><tr><td></td><td></td><td>Median (IQR)</td><td>Median (IQR)</td><td>P Value</td><td>Median (IQR)</td><td>Median (IQR)</td><td>P Value</td></tr><tr><td colspan="2">Age (119)</td><td>71.5(53.3&#8211;78.5)</td><td>74.0(59.3&#8211;83.0)</td><td>0.177</td><td>72.5(I62.5-81.0)</td><td>76.0(58.0&#8211;83.0)</td><td>0.984</td></tr><tr><td colspan="2">Number of LTNCs (119)</td><td>1 (1.0&#8211;2.0)</td><td>1 (1.0&#8211;2.0)</td><td>0.876</td><td>1 (1.0&#8211;2.0)</td><td>1 (1.0&#8211;1.0)</td><td>0.016*</td></tr><tr><td colspan="2">Number of presenting complaints (119)</td><td>1 (1.0&#8211;2.0)</td><td>1 (1.0&#8211;2.0)</td><td>0.829</td><td>1 (1.0&#8211;1.0)</td><td>2 (1.0&#8211;2.0)</td><td>0.040*</td></tr><tr><td colspan="2">FIM score (73) (Score range 1&#8211;126, 126 indicates no impairment)</td><td>111.0(103.0&#8211;120.0)</td><td>113.0(103.0&#8211;120.0)</td><td>0.873</td><td>103.0(96.0&#8211;122.0)</td><td>107.0(45.0&#8211;115.0)</td><td>0.228</td></tr><tr><td colspan="2">GDNS (walking) (74) (score range 1&#8211;5, 5 indicates no impairment)</td><td>2.0 (1.5&#8211;4.0)</td><td>2.0 (0.0&#8211;4.0)</td><td>0.616</td><td>2.5 (0.0&#8211;4.0)</td><td>3.5 (2.0&#8211;4.0)</td><td>0.194</td></tr><tr><td colspan="2">GDNS (speech) (74) (score range 1&#8211;5, 5 indicates no impairment)</td><td>0.5 (0.0&#8211;0.0)</td><td>0.0 (0.0&#8211;2.0)</td><td>0.122</td><td>0.0 (0.0-0.0)</td><td>0.0 (0.0&#8211;3.0)</td><td>0.078</td></tr><tr><td colspan="2">MMSE (49) (score range 1&#8211;30, 30 indicates no impairment)</td><td>24.0(23.0&#8211;28.5)</td><td>26.0(24.0&#8211;28.0)</td><td>0.445</td><td>24.0(18.5&#8211;26.5)</td><td>26.5(23.0&#8211;29.0)</td><td>0.119</td></tr><tr><td colspan="2">Length of stay (119)</td><td>8.0 (4.0&#8211;13.0)</td><td>4.0 (2.0&#8211;13.0)</td><td>0.063</td><td>4.0 (2.0&#8211;8.0)</td><td>10.0 (5.0&#8211;14.0)</td><td>&lt; 0.001*</td></tr></table>
<table><tr><td></td><td></td><td colspan="3">Admission appropriateness</td><td colspan="3">Length of stay appropriateness</td></tr></table>
<table><tr><td></td><td></td><td>Yes</td><td>No</td><td>P Value</td><td>Yes</td><td>No</td><td>P Value</td></tr><tr><td></td><td></td><td>% (n)</td><td>% (n)</td><td></td><td>% (n)</td><td>% (n)</td><td></td></tr><tr><td>Gender</td><td>Female</td><td>70.7 (41)</td><td>29.3 (17)</td><td>0.678</td><td>37.5 (15)</td><td>62.5 (25)</td><td>0.932</td></tr><tr><td></td><td>Male</td><td>74.1 (43)</td><td>25.9 (15)</td><td></td><td>36.6 (15)</td><td>63.4 (26)</td><td></td></tr><tr><td>Admitted via the emergency department?</td><td>Yes</td><td>68.1 (47)</td><td>31.9 (22)</td><td>0.210</td><td>40.0 (18)</td><td>60.0 (27)</td><td>0.537</td></tr><tr><td></td><td>No</td><td>78.7 (37)</td><td>21.3 (10)</td><td></td><td>33.3 (12)</td><td>66.7 (24)</td><td></td></tr><tr><td>Presented with a neurologically related problem?</td><td>Yes</td><td>64.3 (27)</td><td>35.7 (15)</td><td>0.315</td><td>34.6 (9)</td><td>65.4 (17)</td><td>0.343</td></tr><tr><td></td><td>No</td><td>73.7 (42)</td><td>26.3 (15)</td><td></td><td>46.3 (19)</td><td>53.7 (22)</td><td></td></tr><tr><td>Place of residence</td><td>Nursing/residential home</td><td>88.0 (22)</td><td>12.0 (3)</td><td>0.049*</td><td>33.7 (7)</td><td>66.7 (14)</td><td>0.683</td></tr><tr><td></td><td>Own home</td><td>68.1 (62)</td><td>31.9 (29)</td><td></td><td>38.3 (23)</td><td>61.7 (37)</td><td></td></tr><tr><td>Household members</td><td>Lives with others</td><td>69.4 (43)</td><td>30.6 (19)</td><td>0.795</td><td>54.8 (23)</td><td>45.2 (19)</td><td>< 0.001*</td></tr><tr><td></td><td>Lives alone</td><td>66.7 (20)</td><td>33.3 (10)</td><td></td><td>5.3 (1)</td><td>94.7 (18)</td><td></td></tr><tr><td>Receives home help</td><td>Yes</td><td>74.3 (26)</td><td>25.7 (9)</td><td>0.262</td><td>25.0 (6)</td><td>75.0 (18)</td><td>0.058</td></tr><tr><td></td><td>No</td><td>62.7 (32)</td><td>37.3 (19)</td><td></td><td>50.0 (16)</td><td>50.0 (16)</td><td></td></tr><tr><td>Referred to in-patient physiotherapy</td><td>Yes</td><td>n/a</td><td>n/a</td><td>n/a</td><td>25.0 (10)</td><td>75.0 (30)</td><td>0.027*</td></tr><tr><td></td><td>No</td><td></td><td></td><td></td><td>48.8 (20)</td><td>51.2 (21)</td><td></td></tr><tr><td>Referred to social services</td><td>Yes</td><td>n/a</td><td>n/a</td><td>n/a</td><td>9.1 (1)</td><td>90.9 (10)</td><td>0.039*</td></tr><tr><td></td><td>No</td><td></td><td></td><td></td><td>41.4 (29)</td><td>58.6 (41)</td><td></td></tr><tr><td>Transferred on discharge</td><td>Yes</td><td>74.2 (66)</td><td>235.8 (23)</td><td>0.155</td><td>18.2 (2)</td><td>81.8 (9)</td><td>0.164</td></tr><tr><td></td><td>No</td><td>57.0 (11)</td><td>42.1 (8)</td><td></td><td>40.0 (28)</td><td>60.0 (42)</td><td></td></tr><tr><td></td><td></td><td>Median (IQR)</td><td>Median (IQR)</td><td>P Value</td><td>Median (IQR)</td><td>Median (IQR)</td><td>P Value</td></tr><tr><td colspan="2">Age (119)</td><td>71.5(53.3–78.5)</td><td>74.0(59.3–83.0)</td><td>0.177</td><td>72.5(I62.5-81.0)</td><td>76.0(58.0–83.0)</td><td>0.984</td></tr><tr><td colspan="2">Number of LTNCs (119)</td><td>1 (1.0–2.0)</td><td>1 (1.0–2.0)</td><td>0.876</td><td>1 (1.0–2.0)</td><td>1 (1.0–1.0)</td><td>0.016*</td></tr><tr><td colspan="2">Number of presenting complaints (119)</td><td>1 (1.0–2.0)</td><td>1 (1.0–2.0)</td><td>0.829</td><td>1 (1.0–1.0)</td><td>2 (1.0–2.0)</td><td>0.040*</td></tr><tr><td colspan="2">FIM score (73) (Score range 1–126, 126 indicates no impairment)</td><td>111.0(103.0–120.0)</td><td>113.0(103.0–120.0)</td><td>0.873</td><td>103.0(96.0–122.0)</td><td>107.0(45.0–115.0)</td><td>0.228</td></tr><tr><td colspan="2">GDNS (walking) (74) (score range 1–5, 5 indicates no impairment)</td><td>2.0 (1.5–4.0)</td><td>2.0 (0.0–4.0)</td><td>0.616</td><td>2.5 (0.0–4.0)</td><td>3.5 (2.0–4.0)</td><td>0.194</td></tr><tr><td colspan="2">GDNS (speech) (74) (score range 1–5, 5 indicates no impairment)</td><td>0.5 (0.0–0.0)</td><td>0.0 (0.0–2.0)</td><td>0.122</td><td>0.0 (0.0-0.0)</td><td>0.0 (0.0–3.0)</td><td>0.078</td></tr><tr><td colspan="2">MMSE (49) (score range 1–30, 30 indicates no impairment)</td><td>24.0(23.0–28.5)</td><td>26.0(24.0–28.0)</td><td>0.445</td><td>24.0(18.5–26.5)</td><td>26.5(23.0–29.0)</td><td>0.119</td></tr><tr><td colspan="2">Length of stay (119)</td><td>8.0 (4.0–13.0)</td><td>4.0 (2.0–13.0)</td><td>0.063</td><td>4.0 (2.0–8.0)</td><td>10.0 (5.0–14.0)</td><td>< 0.001*</td></tr></table>
9a88ffc33f79e11f9467d4f3193c214bff8e355fb557c29b3b84296fd3beaf26.png
complex
<table><tr><td>Junior</td><td>Intermediate</td><td>Senior</td></tr><tr><td>Supports skills acquisition by using Modelling</td><td>Support growing independent practice by using Coaching</td><td>Fix gaps in competence development by using exploration</td></tr><tr><td>&#8220;...<i>because at this point rather than learning the theory stuff what I want is to acquire clinical abilities and skills when approaching the patients</i>&#8221; (Junior Resident #26).</td><td>&#8220;<i>I think this is the most important one</i>, <i>because it allows me to perform the clinical activities independently whilst receiving supervision and feedback in order to improve the abilities step by step</i>.&#8221; (Intermediate Resident #3)</td><td>&#8220;<i>In this moment my training is almost complete and I think about what am I lacking to face a competitive working market</i>&#8221; (Senior Resident # 75).</td></tr><tr><td>Overcoming deficiencies by using Coaching</td><td>Help expand knowledge base and engage in dialogue with supervisor by using Articulation</td><td>Help expand knowledge base and engage in dialogue with supervisor by using articulation</td></tr><tr><td>&#8220;<i>I think that in this stage of training it would help me to have more feedback with regard to the quality</i>, <i>pertinence and rationally of my actions</i>&#8221; (Resident (Junior) #34)</td><td>&#8220;<i>Laying the foundations of my actions and exploring my strengths and weaknesses allow me to develop and improve my clinical criterion and my decision</i>-<i>making skills</i>&#8221; (Resident (Intermediate) #22)</td><td>&#8220;<i>In this year I think that one already has enough knowledge and training to show what do you know and what you don</i>&#8217;<i>t</i>.&#8221; (Senior Resident #24)</td></tr><tr><td>&#8220;<i>At this level of academic training</i>, <i>initial phase</i>, <i>I will be better helped by permanent feedback in order to fix the fails and to strengthen the right choices</i>...&#8221; ( Junior Resident #71)</td><td rowspan="3">&#8220;<i>Because I consider that it motivates you to make your own decisions and it makes you feel important in the patient care</i>&#8221; (Intermediate Resident #65)</td><td>&#8220;<i>It allow us not only to answer questions but also to formulate them</i>&#8221; (Senior Resident #54)</td></tr><tr><td>Encourage participation by creating a Safe Learning Environment</td><td>Gain confidence in own performance by not be coerced using a Safe learning environment</td></tr><tr><td>&#8220; <i>I think that the supervisor</i>-<i>trainee relationship is very important. If the supervisor creates an environment of trust and respect</i>, <i>it is possible to loose a little bit that formality and rigidity a teacher has and one can ask questions</i>, <i>formulate doubts and even have more security as a student</i>..&#8221; (Junior Resident #80)</td><td>&#8220;...<i>this is the moment to give confidence and respect</i> (<i>to the resident</i>) <i>in terms of what has been taught and modeled</i>, <i>this can only be reflected in a safe learning environment that not coerce our free performance</i>.&#8221; (Senior Resident #18)</td></tr></table>
<table><tr><td>Junior</td><td>Intermediate</td><td>Senior</td></tr><tr><td>Supports skills acquisition by using Modelling</td><td>Support growing independent practice by using Coaching</td><td>Fix gaps in competence development by using exploration</td></tr><tr><td>β€œ...because at this point rather than learning the theory stuff what I want is to acquire clinical abilities and skills when approaching the patients” (Junior Resident #26).</td><td>β€œI think this is the most important one, because it allows me to perform the clinical activities independently whilst receiving supervision and feedback in order to improve the abilities step by step.” (Intermediate Resident #3)</td><td>β€œIn this moment my training is almost complete and I think about what am I lacking to face a competitive working market” (Senior Resident # 75).</td></tr><tr><td>Overcoming deficiencies by using Coaching</td><td>Help expand knowledge base and engage in dialogue with supervisor by using Articulation</td><td>Help expand knowledge base and engage in dialogue with supervisor by using articulation</td></tr><tr><td>β€œI think that in this stage of training it would help me to have more feedback with regard to the quality, pertinence and rationally of my actions” (Resident (Junior) #34)</td><td>β€œLaying the foundations of my actions and exploring my strengths and weaknesses allow me to develop and improve my clinical criterion and my decision-making skills” (Resident (Intermediate) #22)</td><td>β€œIn this year I think that one already has enough knowledge and training to show what do you know and what you don’t.” (Senior Resident #24)</td></tr><tr><td>β€œAt this level of academic training, initial phase, I will be better helped by permanent feedback in order to fix the fails and to strengthen the right choices...” ( Junior Resident #71)</td><td>β€œBecause I consider that it motivates you to make your own decisions and it makes you feel important in the patient care” (Intermediate Resident #65)</td><td>β€œIt allow us not only to answer questions but also to formulate them” (Senior Resident #54)</td></tr></table>
<table><tr><td>Junior</td><td>Intermediate</td><td>Senior</td></tr><tr><td>Encourage participation by creating a Safe Learning Environment</td><td rowspan="2">β€œBecause I consider that it motivates you to make your own decisions and it makes you feel important in the patient care” (Intermediate Resident #65)</td><td>Gain confidence in own performance by not be coerced using a Safe learning environment</td></tr><tr><td>β€œ I think that the supervisor-trainee relationship is very important. If the supervisor creates an environment of trust and respect, it is possible to loose a little bit that formality and rigidity a teacher has and one can ask questions, formulate doubts and even have more security as a student..” (Junior Resident #80)</td><td>β€œ...this is the moment to give confidence and respect (to the resident) in terms of what has been taught and modeled, this can only be reflected in a safe learning environment that not coerce our free performance.” (Senior Resident #18)</td></tr></table>
1e2f34f24111c1dee757f414b235f97892970d783f0f9aec228fcffa9a752975.png
complex
<table><tr><td> </td><td>Item</td><td>Geniposide</td><td>Baicalin</td><td>Palmatine</td><td>Berberine</td><td>Baicalein</td><td>Wogonin</td></tr><tr><td rowspan="2">HRT</td><td>Retention time (<i>t</i><sub><i>R</i></sub>, min)</td><td>17.39</td><td>36.02</td><td>39.54</td><td>39.75</td><td>48.29</td><td>58.33</td></tr><tr><td>Amount (<i>&#956;</i>g<sup>a</sup>)</td><td>15.71 &#177; 0.08</td><td>8.72 &#177; 0.41</td><td>1.10 &#177; 0.03</td><td>19.08 &#177; 0.51</td><td>3.98 &#177; 0.02</td><td>3.50 &#177; 0.01</td></tr></table>
<table><tr><td></td><td>Item</td><td>Geniposide</td><td>Baicalin</td><td>Palmatine</td><td>Berberine</td><td>Baicalein</td><td>Wogonin</td></tr></table>
<table><tr><td rowspan="2">HRT</td><td>Retention time (tR, min)</td><td>17.39</td><td>36.02</td><td>39.54</td><td>39.75</td><td>48.29</td><td>58.33</td></tr><tr><td>Amount (ΞΌga)</td><td>15.71 Β± 0.08</td><td>8.72 Β± 0.41</td><td>1.10 Β± 0.03</td><td>19.08 Β± 0.51</td><td>3.98 Β± 0.02</td><td>3.50 Β± 0.01</td></tr></table>
d8b57c3aaf12760c55f6f79a53b5a091deba84d253427cf905118d76f1e2c9b6.png
simple
<table><tr><td>Template</td><td>Primer/probe (label)</td><td>Sequence (5'-3')</td></tr><tr><td><i>IS</i>481</td><td>Forward primer</td><td>GCCGGATGAACACCCATAAG</td></tr><tr><td></td><td>Reverse primer</td><td>GCGATCAATTGCTGGACCAT</td></tr><tr><td></td><td>Probe (FAM)</td><td>CGATTGACCTTCCTACGTC-MGB</td></tr><tr><td><i>IS</i>1001</td><td>Forward primer</td><td>AATTGCTGCAAGCCAACCA</td></tr><tr><td></td><td>Reverse primer</td><td>CCAGAGCCGTTTGAGTTCGT</td></tr><tr><td></td><td>Probe (VIC)</td><td>ACATAGACCGTCAGCAG-MGB</td></tr><tr><td><i>IS</i>1002</td><td>Forward primer</td><td>CTAGGTCGAGCCCTTCTTGTTAAC</td></tr><tr><td></td><td>Reverse primer</td><td>GCGGGCAAGCCACTTGTA</td></tr><tr><td></td><td>Probe (CY5)</td><td>CATCGTCCAGTTCTGTTGCATCACCC-BBQ</td></tr><tr><td>PhHV</td><td>Forward primer</td><td>GGGCGAATCACAGATTGAATC</td></tr><tr><td></td><td>Reverse primer</td><td>GCGGTTCCAAACGTACCAA</td></tr><tr><td></td><td>Probe (NED)</td><td>TTTTTATGTGTCCGCCACCA-MGB</td></tr></table>
<table><tr><td>Template</td><td>Primer/probe (label)</td><td>Sequence (5'-3')</td></tr><tr><td>IS481</td><td>Forward primer</td><td>GCCGGATGAACACCCATAAG</td></tr><tr><td></td><td>Reverse primer</td><td>GCGATCAATTGCTGGACCAT</td></tr><tr><td></td><td>Probe (FAM)</td><td>CGATTGACCTTCCTACGTC-MGB</td></tr><tr><td>IS1001</td><td>Forward primer</td><td>AATTGCTGCAAGCCAACCA</td></tr><tr><td></td><td>Reverse primer</td><td>CCAGAGCCGTTTGAGTTCGT</td></tr><tr><td></td><td>Probe (VIC)</td><td>ACATAGACCGTCAGCAG-MGB</td></tr><tr><td>IS1002</td><td>Forward primer</td><td>CTAGGTCGAGCCCTTCTTGTTAAC</td></tr><tr><td></td><td>Reverse primer</td><td>GCGGGCAAGCCACTTGTA</td></tr><tr><td></td><td>Probe (CY5)</td><td>CATCGTCCAGTTCTGTTGCATCACCC-BBQ</td></tr></table>
<table><tr><td>Template</td><td>Primer/probe (label)</td><td>Sequence (5'-3')</td></tr><tr><td>PhHV</td><td>Forward primer</td><td>GGGCGAATCACAGATTGAATC</td></tr><tr><td></td><td>Reverse primer</td><td>GCGGTTCCAAACGTACCAA</td></tr><tr><td></td><td>Probe (NED)</td><td>TTTTTATGTGTCCGCCACCA-MGB</td></tr></table>
5f53a2084338e0dfed7aa1674dee0df074dc9e1ff4f5f3dece436e9bdf945d56.png
simple
<table><tr><td>Groups</td><td>Bilateral hippocampus transfection</td><td>Drug administration via caudal vein</td></tr><tr><td>Control</td><td>No surgery</td><td>Saline (10 mL/kg)</td></tr><tr><td>Sham</td><td>Lentiviral</td><td>Saline (10 mL/kg)</td></tr><tr><td>Model</td><td>Lentiviral+miR-30e</td><td>Saline (10 mL/kg)</td></tr><tr><td>TSA low</td><td>Lentiviral+miR-30e</td><td>TSA (10 mL/kg, 1 mg/mL)</td></tr><tr><td>TSA high</td><td>Lentiviral+miR-30e</td><td>TSA (10 mL/kg, 2 mg/mL)</td></tr></table>
<table><tr><td>Groups</td><td>Bilateral hippocampus transfection</td><td>Drug administration via caudal vein</td></tr><tr><td>Control</td><td>No surgery</td><td>Saline (10 mL/kg)</td></tr></table>
<table><tr><td>Sham</td><td>Lentiviral</td><td>Saline (10 mL/kg)</td></tr><tr><td>Model</td><td>Lentiviral+miR-30e</td><td>Saline (10 mL/kg)</td></tr><tr><td>TSA low</td><td>Lentiviral+miR-30e</td><td>TSA (10 mL/kg, 1 mg/mL)</td></tr><tr><td>TSA high</td><td>Lentiviral+miR-30e</td><td>TSA (10 mL/kg, 2 mg/mL)</td></tr></table>
a78e9169424e6b77723684ced6c7b344b99c34ba305e1afaab56e0d75d540c01.png
complex
<table><tr><td>Session</td><td>TAKE 5</td><td>Waist Winners Too</td></tr><tr><td>1</td><td>Benefits of losing weight and motivation towards a healthy lifestyle</td><td>Introduction to health and weight</td></tr><tr><td>2</td><td>Introduction to individualised energy deficit diet and the importance of physical activity</td><td>Planning meals</td></tr><tr><td rowspan="2">3</td><td>Principles of healthy eating and improving physical activity levels</td><td rowspan="2">Food labelling and fats</td></tr><tr><td>Introduction to physical activity diaries and pedometer</td></tr><tr><td rowspan="2">4</td><td>Healthy ways to cook, meal planning and shopping lists</td><td rowspan="2">Food labelling salt and sugar</td></tr><tr><td>Emotions and overeating</td></tr><tr><td rowspan="2">5</td><td>Disadvantages of eating out and take-aways</td><td rowspan="2">Shopping, budgeting, snacks, eating out and take-aways</td></tr><tr><td>Using behaviour change to alter &#8216;bad habits&#8217;</td></tr><tr><td>6</td><td>Coping with cravings and evaluating knowledge of physical activity</td><td>Alcohol and other drinks</td></tr><tr><td>7</td><td>Diet myths and introduction to new ways to motivate participation in physical activity</td><td>Benefits of exercise</td></tr><tr><td>8</td><td>Relapse prevention</td><td>Review</td></tr><tr><td>9</td><td>Evaluate success up to now</td><td>What have we learned</td></tr></table>
<table><tr><td>Session</td><td>TAKE 5</td><td>Waist Winners Too</td></tr><tr><td>1</td><td>Benefits of losing weight and motivation towards a healthy lifestyle</td><td>Introduction to health and weight</td></tr><tr><td>2</td><td>Introduction to individualised energy deficit diet and the importance of physical activity</td><td>Planning meals</td></tr><tr><td rowspan="2">3</td><td>Principles of healthy eating and improving physical activity levels</td><td rowspan="2">Food labelling and fats</td></tr><tr><td>Introduction to physical activity diaries and pedometer</td></tr><tr><td rowspan="2">4</td><td>Healthy ways to cook, meal planning and shopping lists</td><td rowspan="2">Food labelling salt and sugar</td></tr><tr><td>Emotions and overeating</td></tr></table>
<table><tr><td rowspan="2">5</td><td>Disadvantages of eating out and take-aways</td><td rowspan="2">Shopping, budgeting, snacks, eating out and take-aways</td></tr><tr><td>Using behaviour change to alter β€˜bad habits’</td></tr><tr><td>6</td><td>Coping with cravings and evaluating knowledge of physical activity</td><td>Alcohol and other drinks</td></tr><tr><td>7</td><td>Diet myths and introduction to new ways to motivate participation in physical activity</td><td>Benefits of exercise</td></tr><tr><td>8</td><td>Relapse prevention</td><td>Review</td></tr><tr><td>9</td><td>Evaluate success up to now</td><td>What have we learned</td></tr></table>
1df29a4f561b6778c85fb57cecedc6e06fa5d4fdb7bb0c18f675a56342473b8a.png
simple
<table><tr><td>Groups</td><td>Body weight (g)</td><td>Splenomegaly (g)</td><td>Tumor volume (mL)</td><td>Packed cell volume (mL)</td><td>Viable tumor cell count (&#215;10<sup>6 </sup>cells/mL)</td></tr><tr><td>Control L5178Y</td><td>30.83 &#177; 2.41</td><td>0.23 &#177; 0.05</td><td>2.67 &#177; 1.08</td><td>1.30 &#177; 0.49</td><td>412.62 &#177; 35.14</td></tr><tr><td>L5178Y + Globulin UF</td><td>29.32 &#177; 2.89</td><td>0.23 &#177; 0.11</td><td>3.00 &#177; 1.22</td><td>1.12 &#177; 0.87</td><td>286.96 &#177; 92.84</td></tr><tr><td>L5178Y + Glutelin UF</td><td>27.5 &#177; 1.73</td><td>0.19 &#177; 0.02</td><td>4.20 &#177; 0.64 *</td><td>1.97 &#177; 0.60</td><td>415.80 &#177; 92.88</td></tr><tr><td>L5178Y + Albumin SFD</td><td>28.08 &#177; 2.38</td><td>0.20 &#177; 0.07</td><td>0.60 &#177; 0.75 *</td><td>0.50 &#177; 0.30 *</td><td>750.00 &#177; 47.03 *</td></tr><tr><td>L5178Y + Glutelin SFD</td><td>31.06 &#177; 3.20</td><td>0.21 &#177; 0.01</td><td>3.50 &#177; 3.46</td><td>1.02 &#177; 0.95</td><td>365.10 &#177; 223.82</td></tr></table>
<table><tr><td>Groups</td><td>Body weight (g)</td><td>Splenomegaly (g)</td><td>Tumor volume (mL)</td><td>Packed cell volume (mL)</td><td>Viable tumor cell count (Γ—106 cells/mL)</td></tr><tr><td>Control L5178Y</td><td>30.83 Β± 2.41</td><td>0.23 Β± 0.05</td><td>2.67 Β± 1.08</td><td>1.30 Β± 0.49</td><td>412.62 Β± 35.14</td></tr><tr><td>L5178Y + Globulin UF</td><td>29.32 Β± 2.89</td><td>0.23 Β± 0.11</td><td>3.00 Β± 1.22</td><td>1.12 Β± 0.87</td><td>286.96 Β± 92.84</td></tr></table>
<table><tr><td>L5178Y + Glutelin UF</td><td>27.5 Β± 1.73</td><td>0.19 Β± 0.02</td><td>4.20 Β± 0.64 *</td><td>1.97 Β± 0.60</td><td>415.80 Β± 92.88</td></tr><tr><td>L5178Y + Albumin SFD</td><td>28.08 Β± 2.38</td><td>0.20 Β± 0.07</td><td>0.60 Β± 0.75 *</td><td>0.50 Β± 0.30 *</td><td>750.00 Β± 47.03 *</td></tr><tr><td>L5178Y + Glutelin SFD</td><td>31.06 Β± 3.20</td><td>0.21 Β± 0.01</td><td>3.50 Β± 3.46</td><td>1.02 Β± 0.95</td><td>365.10 Β± 223.82</td></tr></table>
5bdb4980199c59f017058a3a7bbe519ae1fa9190b57e41c4b642ee23aebae763.png
complex
<table><tr><td>Weather season</td><td>Monitoring period</td><td>Variable</td><td>Soil temperature</td><td>Soil moisture</td></tr><tr><td rowspan="3">Wet season</td><td>September 2012 </td><td></td><td><i>r</i> = 0.2253 <i>P</i> = 0.1464</td><td><i>r</i> = 0.1955 <i>P</i> = 0.2091</td></tr><tr><td>November 2012 </td><td></td><td><i>r</i> = &#8722;0.5169 <i>P</i> = 0.0001</td><td><i>r</i> = 0.1127 <i>P</i> = 0.4264</td></tr><tr><td>January 2013</td><td rowspan="2">Soil CO<sub>2</sub> emission</td><td><i>r</i> = &#8722;0.4829 <i>P</i> = 0.0004</td><td><i>r</i> = 0.2290 <i>P</i> = 0.1135</td></tr><tr><td rowspan="2">Dry season</td><td>April 2013</td><td><i>r</i> = &#8722;0.7431 <i>P</i> = 0.0001</td><td><i>r</i> = &#8722;0.0776 <i>P</i> = 0.5558</td></tr><tr><td>July 2013</td><td></td><td><i>r</i> = &#8722;0.5992 <i>P</i> = 0.0001</td><td><i>r</i> = &#8722;0.2299 <i>P</i> = 0.0854</td></tr><tr><td colspan="2">Pooling data throughout the wet and dry seasons</td><td></td><td><i>r</i> = &#8722;0.1119 <i>P</i> = 0.0710</td><td><i>r</i> = 0.1027 <i>P</i> = 0.0980</td></tr></table>
<table><tr><td>Weather season</td><td>Monitoring period</td><td>Variable</td><td>Soil temperature</td><td>Soil moisture</td></tr><tr><td rowspan="2">Wet season</td><td>September 2012</td><td></td><td>r = 0.2253 P = 0.1464</td><td>r = 0.1955 P = 0.2091</td></tr><tr><td>November 2012</td><td></td><td>r = βˆ’0.5169 P = 0.0001</td><td>r = 0.1127 P = 0.4264</td></tr></table>
<table><tr><td>Weather season</td><td>Monitoring period</td><td>Variable</td><td>Soil temperature</td><td>Soil moisture</td></tr><tr><td>Wet season</td><td>January 2013</td><td rowspan="2">Soil CO2 emission</td><td>r = βˆ’0.4829 P = 0.0004</td><td>r = 0.2290 P = 0.1135</td></tr><tr><td rowspan="2">Dry season</td><td>April 2013</td><td>r = βˆ’0.7431 P = 0.0001</td><td>r = βˆ’0.0776 P = 0.5558</td></tr><tr><td>July 2013</td><td></td><td>r = βˆ’0.5992 P = 0.0001</td><td>r = βˆ’0.2299 P = 0.0854</td></tr><tr><td colspan="2">Pooling data throughout the wet and dry seasons</td><td></td><td>r = βˆ’0.1119 P = 0.0710</td><td>r = 0.1027 P = 0.0980</td></tr></table>
07295d0fc0d87fd545c23389a42c749b693dfb4bae897170b2bc65387328a036.png
complex
<table><tr><td>Variable</td><td>Experimental schools(mean standard error)</td><td>Control schools(mean standard error)</td><td><i>t </i>(8)</td><td>Cohen's <i>d</i></td></tr><tr><td colspan="5">Screen time</td></tr><tr><td>Child report (hours/week)</td><td>32.5(0.6)</td><td>31.2(1.0)</td><td>.26</td><td>.69</td></tr><tr><td>Parent report (hours/week)</td><td>22.8(0.7)</td><td>24.6(0.3)</td><td>-2.15<sup>a</sup></td><td>1.26</td></tr><tr><td colspan="5">Fruit and vegetable consumption</td></tr><tr><td>Child report (servings/day)</td><td>4.4(0.2)</td><td>4.2(0.1)</td><td>1.78<sup>b</sup></td><td>.52</td></tr><tr><td>Parent report (servings/week)</td><td>24.9(0.7)</td><td>22.6(0.4)</td><td>2.69<sup>a</sup></td><td>1.36</td></tr><tr><td colspan="5">Physical activity</td></tr><tr><td>Pedometer (steps/day)</td><td>12,250(260)</td><td>11,870(232)</td><td>.91</td><td>1.83</td></tr><tr><td colspan="5">Body mass index</td></tr><tr><td>Body mass index (kg/m<sup>2</sup>)</td><td>19.0(0.02)</td><td>19.0(0.03)</td><td>.05</td><td>.38</td></tr></table>
<table><tr><td>Variable</td><td>Experimental schools(mean standard error)</td><td>Control schools(mean standard error)</td><td>t (8)</td><td>Cohen's d</td></tr><tr><td colspan="5">Screen time</td></tr><tr><td>Child report (hours/week)</td><td>32.5(0.6)</td><td>31.2(1.0)</td><td>.26</td><td>.69</td></tr></table>
<table><tr><td>Variable</td><td>Experimental schools(mean standard error)</td><td>Control schools(mean standard error)</td><td>t (8)</td><td>Cohen's d</td></tr><tr><td>Parent report (hours/week)</td><td>22.8(0.7)</td><td>24.6(0.3)</td><td>-2.15a</td><td>1.26</td></tr><tr><td colspan="5">Fruit and vegetable consumption</td></tr><tr><td>Child report (servings/day)</td><td>4.4(0.2)</td><td>4.2(0.1)</td><td>1.78b</td><td>.52</td></tr><tr><td>Parent report (servings/week)</td><td>24.9(0.7)</td><td>22.6(0.4)</td><td>2.69a</td><td>1.36</td></tr><tr><td colspan="5">Physical activity</td></tr><tr><td>Pedometer (steps/day)</td><td>12,250(260)</td><td>11,870(232)</td><td>.91</td><td>1.83</td></tr><tr><td colspan="5">Body mass index</td></tr><tr><td>Body mass index (kg/m2)</td><td>19.0(0.02)</td><td>19.0(0.03)</td><td>.05</td><td>.38</td></tr></table>
451b4ed88ab25e317ee0c176c2db6bdbfcbfc662282292e2dbed399169f3166e.png
simple
<table><tr><td> </td><td>PCOS group</td><td>Control group</td><td><i>P</i></td></tr><tr><td>Total macular thickness (<i>&#956;</i>m)</td><td> </td><td> </td><td> </td></tr><tr><td> Central subfield (CSF)</td><td>242.9 &#177; 19.7</td><td>241.2 &#177; 19.8</td><td><i>0.701</i><sup>1</sup></td></tr><tr><td> Superior inner macula (SIM)</td><td>320.0 &#177; 15.0</td><td>323.8 &#177; 14.1</td><td><i>0.239</i><sup>1</sup></td></tr><tr><td> Temporal inner macula (TIM)</td><td>305.5 &#177; 12.3</td><td>308.6 &#177; 14.2</td><td><i>0.297</i><sup>1</sup></td></tr><tr><td> Inferior inner macula (IIM)</td><td>316.3 &#177; 14.5</td><td>317.0 &#177; 21.4</td><td><i>0.865</i><sup>1</sup></td></tr><tr><td> Nasal inner macula (NIM)</td><td>322.5 &#177; 15.4</td><td>322.8 &#177; 15.5</td><td><i>0.941</i><sup>1</sup></td></tr><tr><td> Superior outer macula (SOM)</td><td>282.6 &#177; 15.0</td><td>285.6 &#177; 14.6</td><td><i>0.358</i><sup>1</sup></td></tr><tr><td> Temporal outer macula (TOM)</td><td>260.7 &#177; 12.6</td><td>263.5 &#177; 13.6</td><td><i>0.349</i><sup>1</sup></td></tr><tr><td> Inferior outer macula (IOM)</td><td>268.9 &#177; 14.8</td><td>268.8 &#177; 15.0</td><td><i>0.980</i><sup>1</sup></td></tr><tr><td> Nasal outer macula (NOM)</td><td>300.7 &#177; 14.1</td><td>299.4 &#177; 19.6</td><td><i>0.737</i><sup>1</sup></td></tr><tr><td>Retinal nerve fiber layer (macula, <i>&#956;</i>m)</td><td> </td><td> </td><td> </td></tr><tr><td> Average macular RNFL </td><td>38.6 &#177; 4.8</td><td>41.0 &#177; 9.5</td><td><i>0.168</i><sup>1</sup></td></tr><tr><td> Superior macular</td><td>33.9 &#177; 5.2</td><td>35.2 &#177; 7.3</td><td><i>0.334</i><sup>1</sup></td></tr><tr><td> Temporal macular</td><td>52.5 &#177; 15.0</td><td>54.2 &#177; 16.1</td><td><i>0.636</i><sup>1</sup></td></tr><tr><td> Inferior macular</td><td>33.8 &#177; 7.2</td><td>35.6 &#177; 7.0</td><td><i>0.258</i><sup>1</sup></td></tr><tr><td> Nasal macular</td><td>35.0 &#177; 11.3</td><td>35.2 &#177; 8.0</td><td><i>0.945</i><sup>1</sup></td></tr></table>
<table><tr><td></td><td>PCOS group</td><td>Control group</td><td>P</td></tr><tr><td>Total macular thickness (ΞΌm)</td><td></td><td></td><td></td></tr><tr><td>Central subfield (CSF)</td><td>242.9 Β± 19.7</td><td>241.2 Β± 19.8</td><td>0.7011</td></tr><tr><td>Superior inner macula (SIM)</td><td>320.0 Β± 15.0</td><td>323.8 Β± 14.1</td><td>0.2391</td></tr><tr><td>Temporal inner macula (TIM)</td><td>305.5 Β± 12.3</td><td>308.6 Β± 14.2</td><td>0.2971</td></tr><tr><td>Inferior inner macula (IIM)</td><td>316.3 Β± 14.5</td><td>317.0 Β± 21.4</td><td>0.8651</td></tr><tr><td>Nasal inner macula (NIM)</td><td>322.5 Β± 15.4</td><td>322.8 Β± 15.5</td><td>0.9411</td></tr><tr><td>Superior outer macula (SOM)</td><td>282.6 Β± 15.0</td><td>285.6 Β± 14.6</td><td>0.3581</td></tr></table>
<table><tr><td>Temporal outer macula (TOM)</td><td>260.7 Β± 12.6</td><td>263.5 Β± 13.6</td><td>0.3491</td></tr><tr><td>Inferior outer macula (IOM)</td><td>268.9 Β± 14.8</td><td>268.8 Β± 15.0</td><td>0.9801</td></tr><tr><td>Nasal outer macula (NOM)</td><td>300.7 Β± 14.1</td><td>299.4 Β± 19.6</td><td>0.7371</td></tr><tr><td>Retinal nerve fiber layer (macula, ΞΌm)</td><td></td><td></td><td></td></tr><tr><td>Average macular RNFL</td><td>38.6 Β± 4.8</td><td>41.0 Β± 9.5</td><td>0.1681</td></tr><tr><td>Superior macular</td><td>33.9 Β± 5.2</td><td>35.2 Β± 7.3</td><td>0.3341</td></tr><tr><td>Temporal macular</td><td>52.5 Β± 15.0</td><td>54.2 Β± 16.1</td><td>0.6361</td></tr><tr><td>Inferior macular</td><td>33.8 Β± 7.2</td><td>35.6 Β± 7.0</td><td>0.2581</td></tr><tr><td>Nasal macular</td><td>35.0 Β± 11.3</td><td>35.2 Β± 8.0</td><td>0.9451</td></tr></table>
f12e9f6735216b1c5c0c844555116cc3af839fad5bcad825f15b961d1a4deacf.png
complex
<table><tr><td>Knowledge</td><td>Frequency</td><td>Percentage</td></tr><tr><td colspan="3">Do you think Condoms can prevent STDs? (<i>N</i> = 581)</td></tr><tr><td> Yes</td><td>443</td><td>76.2</td></tr><tr><td> No</td><td>134</td><td>23.1</td></tr><tr><td> Probably</td><td>4</td><td>0.7</td></tr><tr><td colspan="3">Can HIV transmit through kissing and sharing equipment(<i>N</i> = 583)</td></tr><tr><td> Yes</td><td>243</td><td>41.7</td></tr><tr><td> No</td><td>307</td><td>52.6</td></tr><tr><td> I don&#8217;t know</td><td>33</td><td>5.7</td></tr><tr><td colspan="3">Is HIV STDs? (<i>N</i> = 491)</td></tr><tr><td> Yes</td><td>440</td><td>89.6</td></tr><tr><td> No</td><td>51</td><td>10.4</td></tr><tr><td colspan="3">Can HIV transmit through breast feeding (<i>N</i> = 563)</td></tr><tr><td> Yes</td><td>311</td><td>55.2</td></tr><tr><td> No</td><td>252</td><td>44.8</td></tr><tr><td colspan="3">Know about STDs (<i>N</i> = 576)</td></tr><tr><td> Yes</td><td>510</td><td>88.45</td></tr><tr><td> No</td><td>66</td><td>11.5</td></tr></table>
<table><tr><td>Knowledge</td><td>Frequency</td><td>Percentage</td></tr><tr><td colspan="3">Do you think Condoms can prevent STDs? (N = 581)</td></tr><tr><td>Yes</td><td>443</td><td>76.2</td></tr><tr><td>No</td><td>134</td><td>23.1</td></tr><tr><td>Probably</td><td>4</td><td>0.7</td></tr><tr><td colspan="3">Can </td></tr></table>
<table><tr><td>Knowledge</td><td>Frequency</td><td>Percentage</td></tr><tr><td colspan="3">HIV transmit through kissing and sharing equipment(N = 583)</td></tr><tr><td>Yes</td><td>243</td><td>41.7</td></tr><tr><td>No</td><td>307</td><td>52.6</td></tr><tr><td>I don’t know</td><td>33</td><td>5.7</td></tr><tr><td colspan="3">Is HIV STDs? (N = 491)</td></tr><tr><td>Yes</td><td>440</td><td>89.6</td></tr><tr><td>No</td><td>51</td><td>10.4</td></tr><tr><td colspan="3">Can HIV transmit through breast feeding (N = 563)</td></tr><tr><td>Yes</td><td>311</td><td>55.2</td></tr><tr><td>No</td><td>252</td><td>44.8</td></tr><tr><td colspan="3">Know about STDs (N = 576)</td></tr><tr><td>Yes</td><td>510</td><td>88.45</td></tr><tr><td>No</td><td>66</td><td>11.5</td></tr></table>
e623f84c3bcbbb6f4ff2b236a9867f4dab5c681fd67901a46707327cb9ae9b59.png
complex
<table><tr><td rowspan="2">Items</td><td colspan="3">2010</td><td colspan="3">2011</td></tr><tr><td>Gaoyou</td><td>Pukou</td><td>Rudong</td><td>Gaoyou</td><td>Pukou</td><td>Rudong</td></tr><tr><td>Outpatient reimbursement rate(%)</td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>Village clinics</td><td>25</td><td>40</td><td>25</td><td>35</td><td>40</td><td>30</td></tr><tr><td>THCs</td><td>25</td><td>30</td><td>20</td><td>30</td><td>30</td><td>25</td></tr><tr><td>County-level hospital</td><td>20</td><td>20</td><td>15</td><td>20</td><td>20</td><td>20</td></tr><tr><td>Yearly maximum payment amount</td><td>500</td><td>600</td><td>460</td><td>600</td><td>600</td><td>500</td></tr><tr><td>Rural per capita net income (yuan RMB)</td><td>8825</td><td>11188</td><td>9120</td><td>10170</td><td>13204</td><td>10500</td></tr></table>
<table><tr><td rowspan="2">Items</td><td colspan="3">2010</td><td colspan="3">2011</td></tr><tr><td>Gaoyou</td><td>Pukou</td><td>Rudong</td><td>Gaoyou</td><td>Pukou</td><td>Rudong</td></tr><tr><td>Outpatient reimbursement rate(%)</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Village clinics</td><td>25</td><td>40</td><td>25</td><td>35</td><td>40</td><td>30</td></tr><tr><td>THCs</td><td>25</td><td>30</td><td>20</td><td>30</td><td>30</td><td>25</td></tr></table>
<table><tr><td rowspan="2">Items</td><td colspan="3">2010</td><td colspan="3">2011</td></tr><tr><td>Gaoyou</td><td>Pukou</td><td>Rudong</td><td>Gaoyou</td><td>Pukou</td><td>Rudong</td></tr><tr><td>County-level hospital</td><td>20</td><td>20</td><td>15</td><td>20</td><td>20</td><td>20</td></tr><tr><td>Yearly maximum payment amount</td><td>500</td><td>600</td><td>460</td><td>600</td><td>600</td><td>500</td></tr><tr><td>Rural per capita net income (yuan RMB)</td><td>8825</td><td>11188</td><td>9120</td><td>10170</td><td>13204</td><td>10500</td></tr></table>
fa0409861456990a579b4c91a3a26b3160f91b4e000d18056d9c3ef712533ace.png
simple
<table><tr><td></td><td>IVT Macular Thickness</td><td>SBT Macular Thickness</td><td>p &lt; 0.05</td></tr><tr><td>Baseline</td><td>386.3 &#177; 12.4</td><td>384.1 &#177; 18.9</td><td>0.721</td></tr><tr><td>1 month</td><td>222.7 &#177; 13.4</td><td>220.1 &#177; 15.1</td><td>0.625</td></tr><tr><td>3 months</td><td>228.1 &#177; 10.6</td><td>231.3 &#177; 10.9</td><td>0.580</td></tr><tr><td>6 months</td><td>385.2 &#177; 11.3</td><td>235.4 &#177; 8.7</td><td>0.001</td></tr></table>
<table><tr><td></td><td>IVT Macular Thickness</td><td>SBT Macular Thickness</td><td>p < 0.05</td></tr><tr><td>Baseline</td><td>386.3 Β± 12.4</td><td>384.1 Β± 18.9</td><td>0.721</td></tr><tr><td>1 month</td><td>222.7 Β± 13.4</td><td>220.1 Β± 15.1</td><td>0.625</td></tr></table>
<table><tr><td>3 months</td><td>228.1 Β± 10.6</td><td>231.3 Β± 10.9</td><td>0.580</td></tr><tr><td>6 months</td><td>385.2 Β± 11.3</td><td>235.4 Β± 8.7</td><td>0.001</td></tr></table>
c7bfc95005547b6ca3c338aacd109180e97065a728669f419cb5c242f8221e0b.png
simple
<table><tr><td> </td><td>Number of patients</td><td>Interval between uterine surgery and diagnosis of BML</td><td>Size or type of uterine myoma</td><td>Adjuvant treatment</td><td>Outcome (follow-up period)</td></tr><tr><td>Rivera <i>et al.</i>[3]</td><td>2</td><td>11 years</td><td>6 cm</td><td>GnRH agonist, tamoxifen, aromatase inhibitor</td><td>5 years</td></tr><tr><td> </td><td> </td><td>3 years</td><td>22 &#215; 16 &#215; 10 cm, intramural</td><td>GnRH agonist tamoxifen, aromatase inhibitor</td><td>2 years</td></tr><tr><td>Egberts <i>et al.</i>[4].</td><td>1</td><td>10 years</td><td>-</td><td>GnRH agonist</td><td>3 years</td></tr><tr><td>Mogi <i>et al</i>. [31].</td><td>1</td><td>7 years</td><td>14 m</td><td>GnRH agonist</td><td>-</td></tr><tr><td>Bodner-Alder <i>et al.</i>[32].</td><td>1</td><td>1 year</td><td>6 &#215; 7 cm, subserosal</td><td>GnRH agonist</td><td>3 months</td></tr><tr><td>Nasu <i>et al.</i>[10].</td><td>1</td><td>10 years</td><td>-</td><td>Aromatase inhibitor</td><td>15 months</td></tr><tr><td>Beck <i>et al</i>. [33].</td><td>1</td><td>5 years</td><td>10 &#215; 10 cm, 8 &#215; 8 cm subserosal</td><td>Progesterone</td><td>1 year</td></tr><tr><td>Wentling <i>et al</i>. [34].</td><td>1</td><td>6 years</td><td>5 cm</td><td>Progesterone</td><td>3 years</td></tr><tr><td>Goyle <i>et al</i>. [11].</td><td>1</td><td>5 years</td><td>-</td><td>progesterone</td><td>3 months</td></tr><tr><td>Moon <i>et al</i>. [9].</td><td>1</td><td>-</td><td>6 &#215; 5 cm</td><td>observation</td><td>6 months</td></tr><tr><td>Awonuga <i>et al.</i>[35].</td><td>2</td><td>3 years</td><td>21 cm</td><td>Observation</td><td>-</td></tr><tr><td> </td><td> </td><td>6 years</td><td>Six, ~30 cm (multiple)</td><td>Tamoxifen</td><td>2 years</td></tr><tr><td>Ki <i>et al.</i> (this case report)</td><td>4</td><td>None</td><td>Small</td><td>Observation</td><td>16 years</td></tr><tr><td> </td><td> </td><td>None</td><td>10 &#215; 10 cm</td><td>Observation</td><td>3 months</td></tr><tr><td> </td><td> </td><td>7 years</td><td>8 &#215; 8 cm, 5 &#215; 7 cm</td><td>Observation</td><td>2 months</td></tr><tr><td> </td><td> </td><td>11 years</td><td>10.5 &#215; 8 cm, subserosal</td><td>Observation</td><td>2 years</td></tr></table>
<table><tr><td></td><td>Number of patients</td><td>Interval between uterine surgery and diagnosis of BML</td><td>Size or type of uterine myoma</td><td>Adjuvant treatment</td><td>Outcome (follow-up period)</td></tr><tr><td>Rivera et al.[3]</td><td>2</td><td>11 years</td><td>6 cm</td><td>GnRH agonist, tamoxifen, aromatase inhibitor</td><td>5 years</td></tr><tr><td></td><td></td><td>3 years</td><td>22 Γ— 16 Γ— 10 cm, intramural</td><td>GnRH agonist tamoxifen, aromatase inhibitor</td><td>2 years</td></tr></table>
<table><tr><td>Egberts et al.[4].</td><td>1</td><td>10 years</td><td>-</td><td>GnRH agonist</td><td>3 years</td></tr><tr><td>Mogi et al. [31].</td><td>1</td><td>7 years</td><td>14 m</td><td>GnRH agonist</td><td>-</td></tr><tr><td>Bodner-Alder et al.[32].</td><td>1</td><td>1 year</td><td>6 Γ— 7 cm, subserosal</td><td>GnRH agonist</td><td>3 months</td></tr><tr><td>Nasu et al.[10].</td><td>1</td><td>10 years</td><td>-</td><td>Aromatase inhibitor</td><td>15 months</td></tr><tr><td>Beck et al. [33].</td><td>1</td><td>5 years</td><td>10 Γ— 10 cm, 8 Γ— 8 cm subserosal</td><td>Progesterone</td><td>1 year</td></tr><tr><td>Wentling et al. [34].</td><td>1</td><td>6 years</td><td>5 cm</td><td>Progesterone</td><td>3 years</td></tr><tr><td>Goyle et al. [11].</td><td>1</td><td>5 years</td><td>-</td><td>progesterone</td><td>3 months</td></tr><tr><td>Moon et al. [9].</td><td>1</td><td>-</td><td>6 Γ— 5 cm</td><td>observation</td><td>6 months</td></tr><tr><td>Awonuga et al.[35].</td><td>2</td><td>3 years</td><td>21 cm</td><td>Observation</td><td>-</td></tr><tr><td></td><td></td><td>6 years</td><td>Six, ~30 cm (multiple)</td><td>Tamoxifen</td><td>2 years</td></tr><tr><td>Ki et al. (this case report)</td><td>4</td><td>None</td><td>Small</td><td>Observation</td><td>16 years</td></tr><tr><td></td><td></td><td>None</td><td>10 Γ— 10 cm</td><td>Observation</td><td>3 months</td></tr><tr><td></td><td></td><td>7 years</td><td>8 Γ— 8 cm, 5 Γ— 7 cm</td><td>Observation</td><td>2 months</td></tr><tr><td></td><td></td><td>11 years</td><td>10.5 Γ— 8 cm, subserosal</td><td>Observation</td><td>2 years</td></tr></table>
092ee2c3a090dd8619e3609836e30f95d13f4f9072eb0a1947825d0d6de586dc.png
simple
<table><tr><td>Predictors<sup>a</sup></td><td>Level</td><td><i>&#946;</i></td><td><i>p</i></td><td>95% Confidence Interval</td></tr><tr><td>Sex</td><td>Male/female</td><td>-0.505</td><td>0.135</td><td>-1.169, 0.158</td></tr><tr><td>Living with partner</td><td>Yes/no</td><td>0.756</td><td>0.039<sup>&#8224;</sup></td><td>0.040, 1.472</td></tr><tr><td>Age</td><td>Continuous</td><td>0.016</td><td>0.263</td><td>-0.012, 0.043</td></tr><tr><td>Number of hospitalization days</td><td>Continuous</td><td>0.007</td><td>0.386</td><td>-0.009, 0.024</td></tr><tr><td>Discharged to nursing home</td><td>Yes/no</td><td>1.074</td><td>0.191</td><td>-0.539, 2.688</td></tr><tr><td>Discharged to home</td><td>Yes/no</td><td>1.087</td><td>0.169</td><td>-0.466, 2.640</td></tr><tr><td>Stroke type</td><td>Ischemic/haemorrhagic</td><td>0.210</td><td>0.658</td><td>-0.722, 1.142</td></tr><tr><td>Stroke location</td><td>Left/right</td><td>0.297</td><td>0.365</td><td>-0.348, 0.942</td></tr><tr><td>Diabetes</td><td>Yes/no</td><td>-0.214</td><td>0.589</td><td>-0.994, 0.566</td></tr><tr><td>Alive within 10-year ref/per</td><td>Yes/no</td><td>0.136</td><td>0.705</td><td>-0.569, 0.640</td></tr><tr><td><i>Explained variance</i></td><td><i>0.047 (R</i><sup><i>2</i></sup><i>)</i></td><td></td><td></td><td></td></tr></table>
<table><tr><td>Predictorsa</td><td>Level</td><td>Ξ²</td><td>p</td><td>95% Confidence Interval</td></tr><tr><td>Sex</td><td>Male/female</td><td>-0.505</td><td>0.135</td><td>-1.169, 0.158</td></tr><tr><td>Living with partner</td><td>Yes/no</td><td>0.756</td><td>0.039†</td><td>0.040, 1.472</td></tr><tr><td>Age</td><td>Continuous</td><td>0.016</td><td>0.263</td><td>-0.012, 0.043</td></tr><tr><td>Number of hospitalization days</td><td>Continuous</td><td>0.007</td><td>0.386</td><td>-0.009, 0.024</td></tr><tr><td>Discharged to nursing home</td><td>Yes/no</td><td>1.074</td><td>0.191</td><td>-0.539, 2.688</td></tr><tr><td>Discharged to home</td><td>Yes/no</td><td>1.087</td><td>0.169</td><td>-0.466, 2.640</td></tr><tr><td>Stroke ty</td><td>Ischemi</td><td>0.2</td><td>0.65</td><td>-0.722, 1.14</td></tr></table>
<table><tr><td>Predictorsa</td><td>Level</td><td>Ξ²</td><td>p</td><td>95% Confidence Interval</td></tr><tr><td>pe</td><td>c/haemorrhagic</td><td>10</td><td>8</td><td>2</td></tr><tr><td>Stroke location</td><td>Left/right</td><td>0.297</td><td>0.365</td><td>-0.348, 0.942</td></tr><tr><td>Diabetes</td><td>Yes/no</td><td>-0.214</td><td>0.589</td><td>-0.994, 0.566</td></tr><tr><td>Alive within 10-year ref/per</td><td>Yes/no</td><td>0.136</td><td>0.705</td><td>-0.569, 0.640</td></tr><tr><td>Explained variance</td><td>0.047 (R2)</td><td></td><td></td><td></td></tr></table>
e068c8a05f622eb5ddfb9a325682c702208bee7866d802819c6f21d66ce572db.png
complex
<table><tr><td rowspan="2">Isolate no.</td><td rowspan="2">Isolate or accession no.<sup><i>a</i></sup></td><td rowspan="2">Organism</td><td colspan="2">Amino acid residue at position corresponding to nonsynonymous mutation:</td></tr><tr><td>K137R</td><td>P533L</td></tr><tr><td></td><td>PF3D7_1343700</td><td>P. falciparum</td><td>K168</td><td>P553</td></tr><tr><td></td><td>PVX_083080</td><td>P. vivax</td><td>K152</td><td>P539</td></tr><tr><td></td><td>PKH_121080</td><td>P. knowlesi</td><td>K152</td><td>P539</td></tr><tr><td>1</td><td>PM1A</td><td>P. malariae</td><td></td><td>P</td></tr><tr><td>2</td><td>PM2</td><td>P. malariae</td><td></td><td>P</td></tr><tr><td>3</td><td>PMS</td><td>P. malariae</td><td></td><td>P</td></tr><tr><td>4</td><td>PM1381</td><td>P. malariae</td><td></td><td>P</td></tr><tr><td>5</td><td>PM17</td><td>P. malariae</td><td></td><td>P</td></tr><tr><td>6</td><td>PM18</td><td>P. malariae</td><td></td><td>P</td></tr><tr><td>7</td><td>PM048</td><td>P. malariae</td><td></td><td>L</td></tr><tr><td>8</td><td>PM1S</td><td>P. malariae</td><td></td><td>P</td></tr><tr><td>9</td><td>PM4</td><td>P. malariae</td><td></td><td>P</td></tr><tr><td>10</td><td>PM2848</td><td>P. malariae</td><td></td><td>P</td></tr><tr><td>11</td><td>PM454</td><td>P. malariae</td><td></td><td>P</td></tr><tr><td>12</td><td>PM5</td><td>P. malariae</td><td></td><td>P</td></tr><tr><td>13</td><td>PM1454</td><td>P. malariae</td><td></td><td>P</td></tr><tr><td>14</td><td>PoW1</td><td>P. ovalewallikeri</td><td>K</td><td></td></tr><tr><td>15</td><td>PoW21</td><td>P. ovalewallikeri</td><td>K</td><td></td></tr><tr><td>16</td><td>PoW23</td><td>P. ovalewallikeri</td><td>K</td><td></td></tr><tr><td>17</td><td>PoC13</td><td>P. ovalecurtisi</td><td>K</td><td></td></tr><tr><td>18</td><td>PoW20</td><td>P. ovalewallikeri</td><td>R</td><td></td></tr></table>
<table><tr><td rowspan="2">Isolate no.</td><td rowspan="2">Isolate or accession no.a</td><td rowspan="2">Organism</td><td colspan="2">Amino acid residue at position corresponding to nonsynonymous mutation:</td></tr><tr><td>K137R</td><td>P533L</td></tr><tr><td></td><td>PF3D7_1343700</td><td>P. falciparum</td><td>K168</td><td>P553</td></tr><tr><td></td><td>PVX_083080</td><td>P. vivax</td><td>K152</td><td>P539</td></tr><tr><td></td><td>PKH_121080</td><td>P. knowlesi</td><td>K152</td><td>P539</td></tr><tr><td>1</td><td>PM1A</td><td>P. malariae</td><td></td><td>P</td></tr><tr><td>2</td><td>PM2</td><td>P. malariae</td><td></td><td>P</td></tr><tr><td>3</td><td>PMS</td><td>P. malariae</td><td></td><td>P</td></tr><tr><td>4</td><td>PM1381</td><td>P. malariae</td><td></td><td>P</td></tr><tr><td>5</td><td>PM17</td><td>P. malariae</td><td></td><td>P</td></tr><tr><td>6</td><td>PM18</td><td>P. malariae</td><td></td><td>P</td></tr><tr><td>7</td><td>PM048</td><td>P. malariae</td><td></td><td>L</td></tr><tr><td>8</td><td>PM1S</td><td>P. malariae</td><td></td><td>P</td></tr><tr><td>9</td><td>PM4</td><td>P. malariae</td><td></td><td>P</td></tr><tr><td>10</td><td>PM2848</td><td>P. malariae</td><td></td><td>P</td></tr><tr><td>11</td><td>PM454</td><td>P. malariae</td><td></td><td>P</td></tr><tr><td>12</td><td>PM5</td><td>P. malariae</td><td></td><td>P</td></tr></table>
<table><tr><td rowspan="2">Isolate no.</td><td rowspan="2">Isolate or accession no.a</td><td rowspan="2">Organism</td><td colspan="2">Amino acid residue at position corresponding to nonsynonymous mutation:</td></tr><tr><td>K137R</td><td>P533L</td></tr><tr><td>13</td><td>PM1454</td><td>P. malariae</td><td></td><td>P</td></tr><tr><td>14</td><td>PoW1</td><td>P. ovalewallikeri</td><td>K</td><td></td></tr><tr><td>15</td><td>PoW21</td><td>P. ovalewallikeri</td><td>K</td><td></td></tr><tr><td>16</td><td>PoW23</td><td>P. ovalewallikeri</td><td>K</td><td></td></tr><tr><td>17</td><td>PoC13</td><td>P. ovalecurtisi</td><td>K</td><td></td></tr><tr><td>18</td><td>PoW20</td><td>P. ovalewallikeri</td><td>R</td><td></td></tr></table>
c5324837c9d91486e904ef5e8ace626ed2b85c638937668eea64dbd3112987b2.png
complex
<table><tr><td>Haplotype</td><td>Control Freq.</td><td>Case Freq.</td><td>Coef.</td><td>Odds Ratio</td><td>95% CI</td><td>Z-Score</td><td>P-value</td></tr><tr><td></td><td colspan="7">Discovery Cohort (363 patients)</td></tr><tr><td>TG</td><td>0.33</td><td>0.21</td><td></td><td>1.00</td><td>(reference)</td><td></td><td></td></tr><tr><td>CA</td><td>0.39</td><td>0.42</td><td>0.42</td><td>1.52</td><td>(1.05, 2.21)</td><td>2.21</td><td>0.027</td></tr><tr><td>CG</td><td>0.21</td><td>0.23</td><td>0.56</td><td>1.75</td><td>(1.12, 2.72)</td><td>2.46</td><td>0.014</td></tr><tr><td>TA</td><td>0.07</td><td>0.15</td><td>1.21</td><td>3.36</td><td>(1.77, 6.37)</td><td>3.71</td><td>0.000</td></tr><tr><td></td><td colspan="7">Validation Cohort (209 patients)</td></tr><tr><td>TG</td><td>0.34</td><td>0.20</td><td></td><td>1.00</td><td>(reference)</td><td></td><td></td></tr><tr><td>CA</td><td>0.40</td><td>0.49</td><td>0.68</td><td>1.98</td><td>(1.19, 3.27)</td><td>2.65</td><td>0.008</td></tr><tr><td>CG</td><td>0.18</td><td>0.23</td><td>0.75</td><td>2.11</td><td>(0.99, 4.50)</td><td>1.94</td><td>0.053</td></tr><tr><td>TA</td><td>0.09</td><td>0.09</td><td>0.63</td><td>1.87</td><td>(0.67, 5.23)</td><td>1.20</td><td>0.230</td></tr></table>
<table><tr><td>Haplotype</td><td>Control Freq.</td><td>Case Freq.</td><td>Coef.</td><td>Odds Ratio</td><td>95% CI</td><td>Z-Score</td><td>P-value</td></tr></table>
<table><tr><td></td><td colspan="7">Discovery Cohort (363 patients)</td></tr><tr><td>TG</td><td>0.33</td><td>0.21</td><td></td><td>1.00</td><td>(reference)</td><td></td><td></td></tr><tr><td>CA</td><td>0.39</td><td>0.42</td><td>0.42</td><td>1.52</td><td>(1.05, 2.21)</td><td>2.21</td><td>0.027</td></tr><tr><td>CG</td><td>0.21</td><td>0.23</td><td>0.56</td><td>1.75</td><td>(1.12, 2.72)</td><td>2.46</td><td>0.014</td></tr><tr><td>TA</td><td>0.07</td><td>0.15</td><td>1.21</td><td>3.36</td><td>(1.77, 6.37)</td><td>3.71</td><td>0.000</td></tr><tr><td></td><td colspan="7">Validation Cohort (209 patients)</td></tr><tr><td>TG</td><td>0.34</td><td>0.20</td><td></td><td>1.00</td><td>(reference)</td><td></td><td></td></tr><tr><td>CA</td><td>0.40</td><td>0.49</td><td>0.68</td><td>1.98</td><td>(1.19, 3.27)</td><td>2.65</td><td>0.008</td></tr><tr><td>CG</td><td>0.18</td><td>0.23</td><td>0.75</td><td>2.11</td><td>(0.99, 4.50)</td><td>1.94</td><td>0.053</td></tr><tr><td>TA</td><td>0.09</td><td>0.09</td><td>0.63</td><td>1.87</td><td>(0.67, 5.23)</td><td>1.20</td><td>0.230</td></tr></table>
2016a6a22c4bb64509ae4e91e3e50fcc31be13c4b78eba0271bcbfcc4d82b856.png
simple
<table><tr><td>Material</td><td>No. of samples</td><td>No. of positives</td></tr><tr><td>Manure</td><td>114</td><td>1</td></tr><tr><td>Soil</td><td>84</td><td>0</td></tr><tr><td>Silage</td><td>4</td><td>0</td></tr><tr><td>Before pasteurisation</td><td>11</td><td>3</td></tr><tr><td>After pasteurisation</td><td>11</td><td>0</td></tr><tr><td>After digestion</td><td>11</td><td>0</td></tr></table>
<table><tr><td>Material</td><td>No. of samples</td><td>No. of positives</td></tr><tr><td>Manure</td><td>114</td><td>1</td></tr><tr><td>Soil</td><td>84</td><td>0</td></tr><tr><td>Silage</td><td>4</td><td>0</td></tr></table>
<table><tr><td>Material</td><td>No. of samples</td><td>No. of positives</td></tr><tr><td>Before pasteurisation</td><td>11</td><td>3</td></tr><tr><td>After pasteurisation</td><td>11</td><td>0</td></tr><tr><td>After digestion</td><td>11</td><td>0</td></tr></table>
fcf2a52adfb80ada49777dfeaee616335a789a9d935c774f59a57ec23fd0b0eb.png
simple
<table><tr><td>Peak</td><td>Start</td><td>RT</td><td>End</td><td>Height</td><td>Area</td><td>Area %</td><td>AreaSumPercent</td><td>BasePeakMz</td></tr><tr><td>1</td><td>0.423</td><td>0.474</td><td>0.574</td><td>1605457</td><td>7925924</td><td>20.49</td><td>5.51</td><td>150.1117</td></tr><tr><td>2</td><td>0.641</td><td>0.691</td><td>0.741</td><td>1260173</td><td>3247945</td><td>8.4</td><td>2.26</td><td>139.0495</td></tr><tr><td>3</td><td>5.433</td><td>5.517</td><td>5.617</td><td>929895</td><td>3587468</td><td>9.27</td><td>2.5</td><td>453.3415</td></tr><tr><td>4</td><td>9.274</td><td>9.357</td><td>9.441</td><td>2115277</td><td>5968077</td><td>15.43</td><td>4.15</td><td>568.2943</td></tr><tr><td>5</td><td>9.508</td><td>9.574</td><td>9.675</td><td>1806352</td><td>5584557</td><td>14.44</td><td>3.89</td><td>383.1507</td></tr><tr><td>6</td><td>15.853</td><td>16.054</td><td>16.438</td><td>2043093</td><td>25462871</td><td>65.83</td><td>17.72</td><td>326.377</td></tr><tr><td>7</td><td>18.024</td><td>18.108</td><td>18.225</td><td>3059381</td><td>14141487</td><td>36.56</td><td>9.84</td><td>311.1631</td></tr><tr><td>8</td><td>19.56</td><td>19.711</td><td>19.945</td><td>1145362</td><td>9522103</td><td>24.62</td><td>6.63</td><td>338.34</td></tr><tr><td>9</td><td>21.397</td><td>21.497</td><td>21.614</td><td>2927045</td><td>14662592</td><td>37.91</td><td>10.2</td><td>413.2648</td></tr><tr><td>10</td><td>24.036</td><td>24.654</td><td>25.271</td><td>1030920</td><td>38679784</td><td>100</td><td>26.91</td><td>663.451</td></tr></table>
<table><tr><td>Peak</td><td>Start</td><td>RT</td><td>End</td><td>Height</td><td>Area</td><td>Area %</td><td>AreaSumPercent</td><td>BasePeakMz</td></tr></table>
<table><tr><td>1</td><td>0.423</td><td>0.474</td><td>0.574</td><td>1605457</td><td>7925924</td><td>20.49</td><td>5.51</td><td>150.1117</td></tr><tr><td>2</td><td>0.641</td><td>0.691</td><td>0.741</td><td>1260173</td><td>3247945</td><td>8.4</td><td>2.26</td><td>139.0495</td></tr><tr><td>3</td><td>5.433</td><td>5.517</td><td>5.617</td><td>929895</td><td>3587468</td><td>9.27</td><td>2.5</td><td>453.3415</td></tr><tr><td>4</td><td>9.274</td><td>9.357</td><td>9.441</td><td>2115277</td><td>5968077</td><td>15.43</td><td>4.15</td><td>568.2943</td></tr><tr><td>5</td><td>9.508</td><td>9.574</td><td>9.675</td><td>1806352</td><td>5584557</td><td>14.44</td><td>3.89</td><td>383.1507</td></tr><tr><td>6</td><td>15.853</td><td>16.054</td><td>16.438</td><td>2043093</td><td>25462871</td><td>65.83</td><td>17.72</td><td>326.377</td></tr><tr><td>7</td><td>18.024</td><td>18.108</td><td>18.225</td><td>3059381</td><td>14141487</td><td>36.56</td><td>9.84</td><td>311.1631</td></tr><tr><td>8</td><td>19.56</td><td>19.711</td><td>19.945</td><td>1145362</td><td>9522103</td><td>24.62</td><td>6.63</td><td>338.34</td></tr><tr><td>9</td><td>21.397</td><td>21.497</td><td>21.614</td><td>2927045</td><td>14662592</td><td>37.91</td><td>10.2</td><td>413.2648</td></tr><tr><td>10</td><td>24.036</td><td>24.654</td><td>25.271</td><td>1030920</td><td>38679784</td><td>100</td><td>26.91</td><td>663.451</td></tr></table>
539a492dcb46be56ce292100659ba734c182690ff0175cc73be6455d7225a8a1.png
complex
<table><tr><td>Characteristic</td><td>Entire Cohort (<i>n =</i> 88)</td><td>PD-L1 &#8805;36.5 &#8710;Ct</td><td>PD-L1 &lt; 36.5 &#8710;Ct</td><td><i>p</i>-Value</td><td>PD-L1 IHC &#8805; 1% (IC)</td><td>PD-L1 IHC &lt; 1% (IC)</td><td><i>p</i>-Value</td></tr><tr><td>pT-Stage</td><td></td><td></td><td></td><td rowspan="4">0.096</td><td></td><td></td><td rowspan="4">0.27</td></tr><tr><td>pT2</td><td>24 (27%)</td><td>13 (28%)</td><td>11 (26%)</td><td>8 (28%)</td><td>16 (27%)</td></tr><tr><td>pT3</td><td>47 (53%)</td><td>28 (61%)</td><td>19 (45%)</td><td>18 (62%)</td><td>29 (49%)</td></tr><tr><td>pT4</td><td>17 (20%)</td><td>5 (11%)</td><td>12 (29%)</td><td>3 (10%)</td><td>14 (24%)</td></tr><tr><td>pN-Stage</td><td></td><td></td><td></td><td rowspan="4">0.014</td><td></td><td></td><td rowspan="4">0.019</td></tr><tr><td>pN0</td><td>60 (68%)</td><td>36 (78%)</td><td>24 (57%)</td><td>23 (79%)</td><td>37 (63%)</td></tr><tr><td>pN1</td><td>9 (10%)</td><td>1 (2%)</td><td>8 (19%)</td><td>0 (0%)</td><td>9 (15%)</td></tr><tr><td>pN2</td><td>19 (22%)</td><td>9 (20%)</td><td>10 (24%)</td><td>6 (21%)</td><td>13 (22%)</td></tr><tr><td>Grading</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>WHO 1973</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>G2</td><td>4 (5%)</td><td>3 (7%)</td><td>1 (2%)</td><td>0.34</td><td>2 (7%)</td><td>2 (3%)</td><td>0.47</td></tr><tr><td>G3</td><td>84 (95%)</td><td>43 (93%)</td><td>41 (98%)</td><td></td><td>27 (93%)</td><td>57 (97%)</td><td></td></tr><tr><td></td><td>0 (0%)</td><td>0 (0%)</td><td>0 (0%)</td><td>1.0</td><td>0 (0%)</td><td>0 (0%)</td><td>1.00</td></tr><tr><td>WHO 2016</td><td>88 (100%)</td><td>46 (100%)</td><td>42 (100%)</td><td></td><td>29 (100%)</td><td>59 (100%)</td><td></td></tr><tr><td>Low grade</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>High grade</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>L1</td><td>50 (57%)</td><td>22 (48%)</td><td>28 (66%)</td><td>0.074</td><td>13 (45%)</td><td>37 (62%)</td><td>0.11</td></tr><tr><td>V1</td><td>26 (30%)</td><td>11 (24%)</td><td>15 (36%)</td><td>0.23</td><td>7 (24%)</td><td>19 (32%)</td><td>0.43</td></tr><tr><td>Pn1</td><td>27 (30%)</td><td>17 (37%)</td><td>10 (24%)</td><td>0.18</td><td>12 (41%)</td><td>15 (25%)</td><td>0.13</td></tr><tr><td>Carcinoma <i>in situ</i></td><td>62 (70%)</td><td>32 (70%)</td><td>30 (71%)</td><td>0.85</td><td>17 (58%)</td><td>45 (76%)</td><td>0.092</td></tr><tr><td>Median age (Min./Max.)</td><td>70.2 (41.3&#8211;90.8)</td><td>70.1 (50.7&#8211;85.4)</td><td>70.7 (41.3&#8211;90.8)</td><td>0.45</td><td>70.05 (53.6&#8211;84.4)</td><td>70.28 (41.3&#8211;90.8)</td><td>0.64</td></tr><tr><td>Adjuvant platinum-containing chemotherapy</td><td>29 (33%)</td><td>14 (30%)</td><td>15 (36%)</td><td>0.60</td><td>8 (28%)</td><td>21 (36%)</td><td>0.45</td></tr><tr><td>Median survival time (Min./Max.)</td><td>26.6 (0.03&#8211;135.7)</td><td>39.7 (0.83&#8211;135.7)</td><td>14.53 (0.03&#8211;114.83)</td><td>0.0065</td><td>40.9 (0.08&#8211;135.7)</td><td>20.83 (0.03&#8211;129.4)</td><td>0.088</td></tr><tr><td>Censors:</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Alive</td><td>28 (32%)</td><td>18 (39%)</td><td>10 (24%)</td><td>0.12</td><td>12 (41%)</td><td>16 (27%)</td><td>0.18</td></tr><tr><td>Deceased</td><td>60 (68%)</td><td>28 (61%)</td><td>32 (76%)</td><td>0.12</td><td>17 (59%)</td><td>43 (73%)</td><td>0.18</td></tr><tr><td>Tumor specific death</td><td>37 (42%)</td><td>15 (33%)</td><td>22 (52%)</td><td>0.15</td><td>10 (34%)</td><td>27 (46%)</td><td>0.31</td></tr></table>
<table><tr><td>Characteristic</td><td>Entire Cohort (n = 88)</td><td>PD-L1 β‰₯36.5 βˆ†Ct</td><td>PD-L1 < 36.5 βˆ†Ct</td><td>p-Value</td><td>PD-L1 IHC β‰₯ 1% (IC)</td><td>PD-L1 IHC < 1% (IC)</td><td>p-Value</td></tr><tr><td>pT-Stage</td><td></td><td></td><td></td><td rowspan="4">0.096</td><td></td><td></td><td rowspan="4">0.27</td></tr><tr><td>pT2</td><td>24 (27%)</td><td>13 (28%)</td><td>11 (26%)</td><td>8 (28%)</td><td>16 (27%)</td></tr><tr><td>pT3</td><td>47 (53%)</td><td>28 (61%)</td><td>19 (45%)</td><td>18 (62%)</td><td>29 (49%)</td></tr><tr><td>pT4</td><td>17 (20%)</td><td>5 (11%)</td><td>12 (29%)</td><td>3 (10%)</td><td>14 (24%)</td></tr><tr><td>pN-Stage</td><td></td><td></td><td></td><td rowspan="4">0.014</td><td></td><td></td><td rowspan="4">0.019</td></tr><tr><td>pN0</td><td>60 (68%)</td><td>36 (78%)</td><td>24 (57%)</td><td>23 (79%)</td><td>37 (63%)</td></tr><tr><td>pN1</td><td>9 (10%)</td><td>1 (2%)</td><td>8 (19%)</td><td>0 (0%)</td><td>9 (15%)</td></tr><tr><td>pN2</td><td>19 (22%)</td><td>9 (20%)</td><td>10 (24%)</td><td>6 (21%)</td><td>13 (22%)</td></tr><tr><td>Grading</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>WHO 1973</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>G2</td><td>4 (5%)</td><td>3 (7%)</td><td>1 (2%)</td><td>0.34</td><td>2 (7%)</td><td>2 (3%)</td><td>0.47</td></tr><tr><td>G3</td><td>84 (95%)</td><td>43 (93%)</td><td>41 (98%)</td><td></td><td>27 (93%)</td><td>57 (97%)</td><td></td></tr></table>
<table><tr><td>Characteristic</td><td>Entire Cohort (n = 88)</td><td>PD-L1 β‰₯36.5 βˆ†Ct</td><td>PD-L1 < 36.5 βˆ†Ct</td><td>p-Value</td><td>PD-L1 IHC β‰₯ 1% (IC)</td><td>PD-L1 IHC < 1% (IC)</td><td>p-Value</td></tr><tr><td></td><td>0 (0%)</td><td>0 (0%)</td><td>0 (0%)</td><td>1.0</td><td>0 (0%)</td><td>0 (0%)</td><td>1.00</td></tr><tr><td>WHO 2016</td><td>88 (100%)</td><td>46 (100%)</td><td>42 (100%)</td><td></td><td>29 (100%)</td><td>59 (100%)</td><td></td></tr><tr><td>Low grade</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>High grade</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>L1</td><td>50 (57%)</td><td>22 (48%)</td><td>28 (66%)</td><td>0.074</td><td>13 (45%)</td><td>37 (62%)</td><td>0.11</td></tr><tr><td>V1</td><td>26 (30%)</td><td>11 (24%)</td><td>15 (36%)</td><td>0.23</td><td>7 (24%)</td><td>19 (32%)</td><td>0.43</td></tr><tr><td>Pn1</td><td>27 (30%)</td><td>17 (37%)</td><td>10 (24%)</td><td>0.18</td><td>12 (41%)</td><td>15 (25%)</td><td>0.13</td></tr><tr><td>Carcinoma in situ</td><td>62 (70%)</td><td>32 (70%)</td><td>30 (71%)</td><td>0.85</td><td>17 (58%)</td><td>45 (76%)</td><td>0.092</td></tr><tr><td>Median age (Min./Max.)</td><td>70.2 (41.3–90.8)</td><td>70.1 (50.7–85.4)</td><td>70.7 (41.3–90.8)</td><td>0.45</td><td>70.05 (53.6–84.4)</td><td>70.28 (41.3–90.8)</td><td>0.64</td></tr><tr><td>Adjuvant platinum-containing chemotherapy</td><td>29 (33%)</td><td>14 (30%)</td><td>15 (36%)</td><td>0.60</td><td>8 (28%)</td><td>21 (36%)</td><td>0.45</td></tr><tr><td>Median survival time (Min./Max.)</td><td>26.6 (0.03–135.7)</td><td>39.7 (0.83–135.7)</td><td>14.53 (0.03–114.83)</td><td>0.0065</td><td>40.9 (0.08–135.7)</td><td>20.83 (0.03–129.4)</td><td>0.088</td></tr><tr><td>Censors:</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Alive</td><td>28 (32%)</td><td>18 (39%)</td><td>10 (24%)</td><td>0.12</td><td>12 (41%)</td><td>16 (27%)</td><td>0.18</td></tr><tr><td>Deceased</td><td>60 (68%)</td><td>28 (61%)</td><td>32 (76%)</td><td>0.12</td><td>17 (59%)</td><td>43 (73%)</td><td>0.18</td></tr><tr><td>Tumor specific death</td><td>37 (42%)</td><td>15 (33%)</td><td>22 (52%)</td><td>0.15</td><td>10 (34%)</td><td>27 (46%)</td><td>0.31</td></tr></table>
f80583840ef39205075f8aa14a22f15fa6179de63fe6bdb1d5ebca8fbd3f788a.png
complex
<table><tr><td>Assembly</td><td><i>k</i>-mer</td><td>No. transcripts</td><td>Total Mbp</td><td>Mean transcript length (bp)</td><td>N50 (bp)</td><td>RMBT (%)</td><td>No. transcripts &gt;1 kb</td><td>CEGMA complete/partial (%)</td></tr><tr><td colspan="9">(A) ALL READS: 138 MILLION PAIRS</td></tr><tr><td>Oases SK</td><td>39</td><td>153,729</td><td>255</td><td>1662</td><td>3659</td><td>92</td><td>64,243</td><td>n/d</td></tr><tr><td>Oases MK</td><td></td><td>1,208,328</td><td>2601</td><td>2153</td><td>3487</td><td>96</td><td>763,694</td><td>n/d</td></tr><tr><td>CLC SK</td><td>25</td><td>220,829</td><td>145</td><td>657</td><td>877</td><td>86</td><td>32,545</td><td>n/d</td></tr><tr><td>CLC MK</td><td></td><td>201,432</td><td>210</td><td>1042</td><td>1707</td><td>95</td><td>62,038</td><td>n/d</td></tr><tr><td colspan="9">(B) SUB-SAMPLE OF READS: 30 MILLION PAIRS</td></tr><tr><td>Oases SK</td><td>23</td><td>78,640</td><td>125</td><td>1588</td><td>3144</td><td>90</td><td>34,850</td><td>87.5/98.8</td></tr><tr><td>Oases MK</td><td></td><td>507,954</td><td>1014</td><td>1996</td><td>3068</td><td>94</td><td>319,913</td><td>92.7/99.6</td></tr><tr><td>CLC SK</td><td>25</td><td>97,375</td><td>76</td><td>781</td><td>1346</td><td>87</td><td>16,121</td><td>79.8/94.0</td></tr><tr><td>CLC MK</td><td></td><td>144,789</td><td>190</td><td>1315</td><td>2635</td><td>95</td><td>51,516</td><td>94.8/99.2</td></tr><tr><td>ABySS SK</td><td>35</td><td>53,368</td><td>47</td><td>878</td><td>1439</td><td>59</td><td>12,936</td><td>33.1/65.3</td></tr><tr><td>ABySS MK</td><td></td><td>89,457</td><td>108</td><td>1204</td><td>2158</td><td>87</td><td>32,797</td><td>83.5/96.8</td></tr></table>
<table><tr><td>Assembly</td><td>k-mer</td><td>No. transcripts</td><td>Total Mbp</td><td>Mean transcript length (bp)</td><td>N50 (bp)</td><td>RMBT (%)</td><td>No. transcripts >1 kb</td><td>CEGMA complete/partial (%)</td></tr><tr><td colspan="9">(A) ALL READS: 138 MILLION PAIRS</td></tr><tr><td>Oases SK</td><td>39</td><td>153,729</td><td>255</td><td>1662</td><td>3659</td><td>92</td><td>64,243</td><td>n/d</td></tr><tr><td>Oases MK</td><td></td><td>1,208,328</td><td>2601</td><td>2153</td><td>3487</td><td>96</td><td>763,694</td><td>n/d</td></tr><tr><td>CLC SK</td><td>25</td><td>220,829</td><td>145</td><td>657</td><td>877</td><td>86</td><td>32,545</td><td>n/d</td></tr><tr><td>CLC MK</td><td></td><td>201,432</td><td>210</td><td>1042</td><td>1707</td><td>95</td><td>62,038</td><td>n/d</td></tr><tr><td colspan="9">(B) SUB-SAMPLE OF READS: 30 MILLION PAIRS</td></tr><tr><td>Oases SK</td><td>23</td><td>78,640</td><td>125</td><td>1588</td><td>3144</td><td>90</td><td>34,850</td><td>87.5/98.8</td></tr></table>
<table><tr><td>Assembly</td><td>k-mer</td><td>No. transcripts</td><td>Total Mbp</td><td>Mean transcript length (bp)</td><td>N50 (bp)</td><td>RMBT (%)</td><td>No. transcripts >1 kb</td><td>CEGMA complete/partial (%)</td></tr><tr><td>Oases MK</td><td></td><td>507,954</td><td>1014</td><td>1996</td><td>3068</td><td>94</td><td>319,913</td><td>92.7/99.6</td></tr><tr><td>CLC SK</td><td>25</td><td>97,375</td><td>76</td><td>781</td><td>1346</td><td>87</td><td>16,121</td><td>79.8/94.0</td></tr><tr><td>CLC MK</td><td></td><td>144,789</td><td>190</td><td>1315</td><td>2635</td><td>95</td><td>51,516</td><td>94.8/99.2</td></tr><tr><td>ABySS SK</td><td>35</td><td>53,368</td><td>47</td><td>878</td><td>1439</td><td>59</td><td>12,936</td><td>33.1/65.3</td></tr><tr><td>ABySS MK</td><td></td><td>89,457</td><td>108</td><td>1204</td><td>2158</td><td>87</td><td>32,797</td><td>83.5/96.8</td></tr></table>
228c75463efaa506ba8baf972e4882fb2e6c4856a8c4c59115fc83a0fee76b6c.png
complex
<table><tr><td rowspan="2">Amino Acid</td><td colspan="2">Relative Content (g/100 g) <sup>a,b</sup></td></tr><tr><td>ACP</td><td>CCP</td></tr><tr><td>Asp</td><td>5.68</td><td>5.17</td></tr><tr><td>Glu</td><td>10.51</td><td>11.53</td></tr><tr><td>Ser</td><td>3.38</td><td>3.17</td></tr><tr><td>Gly</td><td>19.84</td><td>21.28</td></tr><tr><td>His</td><td>3.27</td><td>2.97</td></tr><tr><td>Thr</td><td>7.90</td><td>8.51</td></tr><tr><td>Ala</td><td>4.09</td><td>4.68</td></tr><tr><td>Pro</td><td>12.47</td><td>12.18</td></tr><tr><td>Arg</td><td>8.61</td><td>8.47</td></tr><tr><td>Tyr</td><td>2.28</td><td>1.79</td></tr><tr><td>Val</td><td>3.06</td><td>2.90</td></tr><tr><td>Met</td><td>1.79</td><td>1.27</td></tr><tr><td>Cys</td><td>2.39</td><td>2.08</td></tr><tr><td>Ile</td><td>4.11</td><td>3.93</td></tr><tr><td>Leu</td><td>0.70</td><td>0.08</td></tr><tr><td>Phe</td><td>9.31</td><td>9.36</td></tr><tr><td>Lys</td><td>0.61</td><td>0.62</td></tr><tr><td>Total</td><td>100.00</td><td>100.00</td></tr></table>
<table><tr><td rowspan="2">Amino Acid</td><td colspan="2">Relative Content (g/100 g) a,b</td></tr><tr><td>ACP</td><td>CCP</td></tr><tr><td>Asp</td><td>5.68</td><td>5.17</td></tr><tr><td>Glu</td><td>10.51</td><td>11.53</td></tr></table>
<table><tr><td rowspan="2">Amino Acid</td><td colspan="2">Relative Content (g/100 g) a,b</td></tr><tr><td>ACP</td><td>CCP</td></tr><tr><td>Ser</td><td>3.38</td><td>3.17</td></tr><tr><td>Gly</td><td>19.84</td><td>21.28</td></tr><tr><td>His</td><td>3.27</td><td>2.97</td></tr><tr><td>Thr</td><td>7.90</td><td>8.51</td></tr><tr><td>Ala</td><td>4.09</td><td>4.68</td></tr><tr><td>Pro</td><td>12.47</td><td>12.18</td></tr><tr><td>Arg</td><td>8.61</td><td>8.47</td></tr><tr><td>Tyr</td><td>2.28</td><td>1.79</td></tr><tr><td>Val</td><td>3.06</td><td>2.90</td></tr><tr><td>Met</td><td>1.79</td><td>1.27</td></tr><tr><td>Cys</td><td>2.39</td><td>2.08</td></tr><tr><td>Ile</td><td>4.11</td><td>3.93</td></tr><tr><td>Leu</td><td>0.70</td><td>0.08</td></tr><tr><td>Phe</td><td>9.31</td><td>9.36</td></tr><tr><td>Lys</td><td>0.61</td><td>0.62</td></tr><tr><td>Total</td><td>100.00</td><td>100.00</td></tr></table>
cb016346f8e4307d3271a43d7b603938f8091d872c016e47e18ae6d5ed01edab.png
complex
<table><tr><td rowspan="2"></td><td>Boys</td><td>Girls</td></tr><tr><td>N = 139</td><td>N = 144</td></tr><tr><td></td><td>Mean [percentage]</td><td>Mean [percentage]</td></tr><tr><td>Migrant families</td><td>[79.7%]</td><td>[83.0%]</td></tr><tr><td>Native-born families</td><td>[20.3%]</td><td>[17.0%]</td></tr><tr><td>Age</td><td>4.25 (SD 0.88)</td><td>4.25 (SD 0.82)</td></tr><tr><td><i>Area of education</i></td><td></td><td></td></tr><tr><td>St Gallus</td><td>[25.2%]</td><td>[30.6%]</td></tr><tr><td>St Pius</td><td>[19.4%]</td><td>[14.6%]</td></tr><tr><td>St Fidelis</td><td>[17.3%]</td><td>[16.0%]</td></tr><tr><td>St. Martin</td><td>[15.1%]</td><td>[17.4%]</td></tr><tr><td>St. Michael</td><td>[23.0%]</td><td>[21.4%]</td></tr><tr><td><i>Origin of migrant families:</i></td><td></td><td></td></tr><tr><td>Asia</td><td>[40.2%]</td><td>[45.5%]</td></tr><tr><td>Africa</td><td>[40.2%]</td><td>[30.3%]</td></tr><tr><td>Eastern Europe</td><td>[15.2%]</td><td>[5.1%]</td></tr><tr><td>Western Europe</td><td>[3.3%]</td><td>[15.2%]</td></tr><tr><td>North and South America</td><td>[1.1%]</td><td>[4%]</td></tr></table>
<table><tr><td rowspan="2"></td><td>Boys</td><td>Girls</td></tr><tr><td>N =</td><td>N =</td></tr></table>
<table><tr><td></td><td> 139</td><td> 144</td></tr><tr><td></td><td>Mean [percentage]</td><td>Mean [percentage]</td></tr><tr><td>Migrant families</td><td>[79.7%]</td><td>[83.0%]</td></tr><tr><td>Native-born families</td><td>[20.3%]</td><td>[17.0%]</td></tr><tr><td>Age</td><td>4.25 (SD 0.88)</td><td>4.25 (SD 0.82)</td></tr><tr><td>Area of education</td><td></td><td></td></tr><tr><td>St Gallus</td><td>[25.2%]</td><td>[30.6%]</td></tr><tr><td>St Pius</td><td>[19.4%]</td><td>[14.6%]</td></tr><tr><td>St Fidelis</td><td>[17.3%]</td><td>[16.0%]</td></tr><tr><td>St. Martin</td><td>[15.1%]</td><td>[17.4%]</td></tr><tr><td>St. Michael</td><td>[23.0%]</td><td>[21.4%]</td></tr><tr><td>Origin of migrant families:</td><td></td><td></td></tr><tr><td>Asia</td><td>[40.2%]</td><td>[45.5%]</td></tr><tr><td>Africa</td><td>[40.2%]</td><td>[30.3%]</td></tr><tr><td>Eastern Europe</td><td>[15.2%]</td><td>[5.1%]</td></tr><tr><td>Western Europe</td><td>[3.3%]</td><td>[15.2%]</td></tr><tr><td>North and South America</td><td>[1.1%]</td><td>[4%]</td></tr></table>
2469abbb6cf8939247c98ae58f6ffa7b3cf04e2eab5ea0bad4b5d9ae522c92ce.png
complex
<table><tr><td> </td><td> </td><td>ILOC</td><td>p-value</td><td>PLOC</td><td>p-value</td><td>CLOC</td><td>p-value</td></tr><tr><td>Behaviour</td><td> </td><td>OR (95% CI)</td><td> </td><td>OR (95% CI)</td><td> </td><td>OR (95% CI)</td><td> </td></tr><tr><td rowspan="3">Cigarette smoking (N=3229 )</td><td>Non-Smoker</td><td>1</td><td> </td><td>1</td><td> </td><td>1</td><td> </td></tr><tr><td>Ex-Smoker</td><td>1.01 (0.95-1.07)</td><td>0.826</td><td>0.95 (0.89-1.01)</td><td>0.084</td><td>0.96 (0.91-1.02)</td><td>0.230</td></tr><tr><td>Smoker</td><td>1.01 (0.96-1.06)</td><td>0.778</td><td>0.97 (0.92-1.02)</td><td>0.165</td><td>1.09 (1.04-1-15)</td><td>0.001</td></tr><tr><td rowspan="5">Alcohol consumption (N=3271)</td><td>Never</td><td>1</td><td> </td><td>1</td><td> </td><td>1</td><td> </td></tr><tr><td>Less than once a week</td><td>1.03 (0.96-1.11)</td><td>0.449</td><td>1.03 (0.95-1.11)</td><td>0.494</td><td>0.97 (0.90-1.04)</td><td>0.397</td></tr><tr><td>Once a week</td><td>1.04 (0.97-1-12)</td><td>0.318</td><td>0.99 (0.92-1.07)</td><td>0.847</td><td>0.96 (0.89-1.04)</td><td>0.318</td></tr><tr><td>Several times every week</td><td>1.04 (0.97-1-12)</td><td>0.297</td><td>0.94 (0.87-1.01)</td><td>0.111</td><td>1.02 (0.95-1.10)</td><td>0.563</td></tr><tr><td>Every day or more</td><td>1.07 (0.93-1.23)</td><td>0.363</td><td>0.95 (0.82-1.09)</td><td>0.442</td><td>1.19 (0.97-1.07)</td><td>0.013</td></tr><tr><td rowspan="2">Drug intake (N=3189)</td><td>No</td><td>1</td><td rowspan="2">0.801</td><td>1</td><td rowspan="2">0.012</td><td>1</td><td rowspan="2">0.319</td></tr><tr><td>Yes</td><td>0.99 (0.93-1.06)</td><td>0.92 (0.85-0.98)</td><td>1.04 (0.97-1.11)</td></tr><tr><td rowspan="3">Weight (N=3154)</td><td>Underweight</td><td>0.93 (0.84-1.02)</td><td>0.116</td><td>1.10 (0.99-1.22)</td><td>0.069</td><td>0.91 (0.82-1.01)</td><td>0.068</td></tr><tr><td>Normal weight</td><td>1</td><td> </td><td>1</td><td> </td><td>1</td><td> </td></tr><tr><td>Overweight</td><td>0.98 (0.93-1.04)</td><td>0.562</td><td>1.04 (0.99-1.10)</td><td>0.133</td><td>1.04 (0.98-1.09)</td><td>0.019</td></tr><tr><td rowspan="3">Physical activity (N=3263)</td><td>At least 3 times a week</td><td>1</td><td> </td><td>1</td><td> </td><td>1</td><td> </td></tr><tr><td>1 to 2 times a week</td><td>0.87 (0.83-0.91)</td><td>&lt;0.001</td><td>1.08 (1.03-1.13)</td><td>0.002</td><td>1.06 (1.01-1.11)</td><td>0.019</td></tr><tr><td>Less than once a week</td><td>0.86 (0.81-0.91)</td><td>&lt;0.001</td><td>1.07 (1.01-1.13)</td><td>0.026</td><td>1.12 (1.06-1.18)</td><td>&lt;0.001</td></tr><tr><td rowspan="4">Importance of healthy nutrition (N=3281)</td><td>Very important</td><td>1</td><td> </td><td>1</td><td> </td><td>1</td><td> </td></tr><tr><td>Somewhat important</td><td>0.89 (0.84-0.94)</td><td>&lt;0.001</td><td>1.02 (0.97-1.08)</td><td>0.458</td><td>1.04 (0.99-1.10)</td><td>0.140</td></tr><tr><td>Important</td><td>0.79 (0.74-0.84)</td><td>&lt;0.001</td><td>0.96 (0.90-1.02)</td><td>0.135</td><td>1.10 (1.04-1.17)</td><td>0.001</td></tr><tr><td>Somewhat unimportant</td><td>0.79 (0.72-0.87)</td><td>&lt;0.001</td><td>0.90 (0.82-0.99)</td><td>0.025</td><td>1.25 (1.14-1.37)</td><td>&lt;0.001</td></tr><tr><td> </td><td>Very unimportant</td><td>0.64 (0.55-0.74)</td><td>&lt;0.001</td><td>0.83 (0.71-0.97)</td><td>0.016</td><td>1.29 (1.11-1.49)</td><td>0.001</td></tr></table>
<table><tr><td></td><td></td><td>ILOC</td><td>p-value</td><td>PLOC</td><td>p-value</td><td>CLOC</td><td>p-value</td></tr><tr><td>Behaviour</td><td></td><td>OR (95% CI)</td><td></td><td>OR (95% CI)</td><td></td><td>OR (95% CI)</td><td></td></tr><tr><td rowspan="3">Cigarette smoking (N=3229 )</td><td>Non-Smoker</td><td>1</td><td></td><td>1</td><td></td><td>1</td><td></td></tr><tr><td>Ex-Smoker</td><td>1.01 (0.95-1.07)</td><td>0.826</td><td>0.95 (0.89-1.01)</td><td>0.084</td><td>0.96 (0.91-1.02)</td><td>0.230</td></tr><tr><td>Smoker</td><td>1.01 (0.96-1.06)</td><td>0.778</td><td>0.97 (0.92-1.02)</td><td>0.165</td><td>1.09 (1.04-1-15)</td><td>0.001</td></tr><tr><td rowspan="5">Alcohol consumption (N=3271)</td><td>Never</td><td>1</td><td></td><td>1</td><td></td><td>1</td><td></td></tr><tr><td>Less than once a week</td><td>1.03 (0.96-1.11)</td><td>0.449</td><td>1.03 (0.95-1.11)</td><td>0.494</td><td>0.97 (0.90-1.04)</td><td>0.397</td></tr><tr><td>Once a week</td><td>1.04 (0.97-1-12)</td><td>0.318</td><td>0.99 (0.92-1.07)</td><td>0.847</td><td>0.96 (0.89-1.04)</td><td>0.318</td></tr><tr><td>Several times every week</td><td>1.04 (0.97-1-12)</td><td>0.297</td><td>0.94 (0.87-1.01)</td><td>0.111</td><td>1.02 (0.95-1.10)</td><td>0.563</td></tr><tr><td>Every day or more</td><td>1.07 (0.93-1.23)</td><td>0.363</td><td>0.95 (0.82-1.09)</td><td>0.442</td><td>1.19 (0.97-1.07)</td><td>0.013</td></tr><tr><td rowspan="2">Drug intake (N=3189)</td><td>No</td><td>1</td><td rowspan="2">0.801</td><td>1</td><td rowspan="2">0.012</td><td>1</td><td rowspan="2">0.319</td></tr><tr><td>Yes</td><td>0.99 (0.93-1.06)</td><td>0.92 (0.85-0.98)</td><td>1.04 (0.97-1.11)</td></tr><tr><td>Weight (N=31</td><td>Underweig</td><td>0.9</td><td>0.1</td><td>1.10 (0.99-1.22</td><td></td><td>0.91 (0.8</td><td></td></tr></table>
<table><tr><td></td><td></td><td>ILOC</td><td>p-value</td><td>PLOC</td><td>p-value</td><td>CLOC</td><td>p-value</td></tr><tr><td>Behaviour</td><td></td><td>OR (95% CI)</td><td></td><td>OR (95% CI)</td><td></td><td>OR (95% CI)</td><td></td></tr><tr><td rowspan="3">54)</td><td>ht</td><td>3 (0.84-1.02)</td><td>16</td><td>)</td><td>0.069</td><td>2-1.01)</td><td>0.068</td></tr><tr><td>Normal weight</td><td>1</td><td></td><td>1</td><td></td><td>1</td><td></td></tr><tr><td>Overweight</td><td>0.98 (0.93-1.04)</td><td>0.562</td><td>1.04 (0.99-1.10)</td><td>0.133</td><td>1.04 (0.98-1.09)</td><td>0.019</td></tr><tr><td rowspan="3">Physical activity (N=3263)</td><td>At least 3 times a week</td><td>1</td><td></td><td>1</td><td></td><td>1</td><td></td></tr><tr><td>1 to 2 times a week</td><td>0.87 (0.83-0.91)</td><td><0.001</td><td>1.08 (1.03-1.13)</td><td>0.002</td><td>1.06 (1.01-1.11)</td><td>0.019</td></tr><tr><td>Less than once a week</td><td>0.86 (0.81-0.91)</td><td><0.001</td><td>1.07 (1.01-1.13)</td><td>0.026</td><td>1.12 (1.06-1.18)</td><td><0.001</td></tr><tr><td rowspan="4">Importance of healthy nutrition (N=3281)</td><td>Very important</td><td>1</td><td></td><td>1</td><td></td><td>1</td><td></td></tr><tr><td>Somewhat important</td><td>0.89 (0.84-0.94)</td><td><0.001</td><td>1.02 (0.97-1.08)</td><td>0.458</td><td>1.04 (0.99-1.10)</td><td>0.140</td></tr><tr><td>Important</td><td>0.79 (0.74-0.84)</td><td><0.001</td><td>0.96 (0.90-1.02)</td><td>0.135</td><td>1.10 (1.04-1.17)</td><td>0.001</td></tr><tr><td>Somewhat unimportant</td><td>0.79 (0.72-0.87)</td><td><0.001</td><td>0.90 (0.82-0.99)</td><td>0.025</td><td>1.25 (1.14-1.37)</td><td><0.001</td></tr><tr><td></td><td>Very unimportant</td><td>0.64 (0.55-0.74)</td><td><0.001</td><td>0.83 (0.71-0.97)</td><td>0.016</td><td>1.29 (1.11-1.49)</td><td>0.001</td></tr></table>
b7d67f440601d2a69af6d03005f6f8845bfdfaf8b7ca9d52b838fb96b185ea1c.png
simple
<table><tr><td>Cluster</td><td>Tree distance</td><td><i>q</i></td><td><i>q<sup>+</sup></i></td></tr><tr><td>dro1</td><td>0.039669</td><td>0.961108</td><td>1</td></tr><tr><td>dro2</td><td>0.21</td><td>0.810584</td><td>0.849477</td></tr><tr><td>dro_anoGam</td><td>0.191225384</td><td>0.825946</td><td>0.864839</td></tr><tr><td>dro_apiMel</td><td>0.231922</td><td>0.793008</td><td>0.8319</td></tr><tr><td>dro_triCas</td><td>0.324132615</td><td>0.723154</td><td>0.762047</td></tr><tr><td>all</td><td>0.3252756</td><td>0.722328</td><td>0.761221</td></tr></table>
<table><tr><td>Cluster</td><td>Tree distance</td><td>q</td><td>q+</td></tr><tr><td>dro1</td><td>0.039669</td><td>0.961108</td><td>1</td></tr><tr><td>dro2</td><td>0.21</td><td>0.810584</td><td>0.849477</td></tr><tr><td>dro</td><td>0.19122</td><td>0.</td><td>0.</td></tr></table>
<table><tr><td>_anoGam</td><td>5384</td><td>825946</td><td>864839</td></tr><tr><td>dro_apiMel</td><td>0.231922</td><td>0.793008</td><td>0.8319</td></tr><tr><td>dro_triCas</td><td>0.324132615</td><td>0.723154</td><td>0.762047</td></tr><tr><td>all</td><td>0.3252756</td><td>0.722328</td><td>0.761221</td></tr></table>
d70e6e178a1815898dd30ca5632ab5315e146a8437906cc174bd7e5f69507700.png
complex
<table><tr><td rowspan="2">PHB/ENR-50 composition</td><td rowspan="2">Clay content (wt%)</td><td colspan="4">DSC *</td><td colspan="5">TG-DTG **</td></tr><tr><td><i>T</i><sub>g1</sub> (&#176;C)</td><td><i>T</i><sub>g2</sub> (&#176;C)</td><td><i>T<sub>m</sub></i> (&#176;C)</td><td>&#8710;<i>H</i><sub>m</sub> (J/g)</td><td><i>T</i><sub>10</sub> (&#176;C)</td><td><i>T</i><sub>20</sub> (&#176;C)</td><td><i>T</i><sub>30</sub> (&#176;C)</td><td><i>T</i><sub>max1</sub> (&#176;C)</td><td><i>T</i><sub>max2</sub> (&#176;C)</td></tr><tr><td rowspan="4">30/70</td><td>0</td><td>&#8722;18.1</td><td>&#8211;</td><td>169.6</td><td>25.8</td><td>255.6</td><td>281.5</td><td>370.4</td><td>280.9</td><td>433.1</td></tr><tr><td>1</td><td>&#8722;18.8</td><td>53.5</td><td>172.4</td><td>4.1</td><td>270.4</td><td>318.5</td><td>366.7</td><td>332.8</td><td>438.2</td></tr><tr><td>3</td><td>&#8211;</td><td>49.3</td><td>&#8211;</td><td>&#8211;</td><td>296.3</td><td>366.7</td><td>403.7</td><td>310.9</td><td>432.7</td></tr><tr><td>5</td><td>&#8211;</td><td>60.0</td><td>&#8211;</td><td>&#8211;</td><td>314.8</td><td>377.8</td><td>414.8</td><td>291.0</td><td>430.7</td></tr><tr><td rowspan="4">50/50</td><td>0</td><td>&#8722;17.7</td><td>&#8211;</td><td>170.2</td><td>37.5</td><td>248.2</td><td>259.3</td><td>270.4</td><td>279.1</td><td>437.8</td></tr><tr><td>1</td><td>&#8211;</td><td>60.7</td><td>172.4</td><td>9.1</td><td>266.7</td><td>281.5</td><td>307.4</td><td>313.9</td><td>431.5</td></tr><tr><td>3</td><td>&#8211;</td><td>57.3</td><td>&#8211;</td><td>&#8211;</td><td>274.1</td><td>340.7</td><td>388.9</td><td>300.0</td><td>429.5</td></tr><tr><td>5</td><td>&#8211;</td><td>58.6</td><td>&#8211;</td><td>&#8211;</td><td>285.2</td><td>388.9</td><td>425.9</td><td>294.4</td><td>441.0</td></tr><tr><td rowspan="4">70/30</td><td>0</td><td>&#8722;19.3</td><td>&#8211;</td><td>173.1</td><td>53.7</td><td>235.2</td><td>242.6</td><td>248.2</td><td>276.9</td><td>414.2</td></tr><tr><td>1</td><td>&#8211;</td><td>58.0</td><td>172.8</td><td>18.3</td><td>281.5</td><td>292.6</td><td>300.0</td><td>303.6</td><td>446.7</td></tr><tr><td>3</td><td>&#8211;</td><td>57.4</td><td>170.0</td><td>1.9</td><td>274.1</td><td>296.3</td><td>377.8</td><td>297.9</td><td>438.7</td></tr><tr><td>5</td><td>&#8211;</td><td>54.3</td><td>&#8211;</td><td>&#8211;</td><td>266.7</td><td>355.6</td><td>407.4</td><td>284.1</td><td>429.5</td></tr></table>
<table><tr><td rowspan="2">PHB/ENR-50 composition</td><td rowspan="2">Clay content (wt%)</td><td colspan="4">DSC *</td><td colspan="5">TG-DTG **</td></tr><tr><td>Tg1 (Β°C)</td><td>Tg2 (Β°C)</td><td>Tm (Β°C)</td><td>βˆ†Hm (J/g)</td><td>T10 (Β°C)</td><td>T20 (Β°C)</td><td>T30 (Β°C)</td><td>Tmax1 (Β°C)</td><td>Tmax2 (Β°C)</td></tr><tr><td rowspan="4">30/70</td><td>0</td><td>βˆ’18.1</td><td>–</td><td>169.6</td><td>25.8</td><td>255.6</td><td>281.5</td><td>370.4</td><td>280.9</td><td>433.1</td></tr><tr><td>1</td><td>βˆ’18.8</td><td>53.5</td><td>172.4</td><td>4.1</td><td>270.4</td><td>318.5</td><td>366.7</td><td>332.8</td><td>438.2</td></tr><tr><td>3</td><td>–</td><td>49.3</td><td>–</td><td>–</td><td>296.3</td><td>366.7</td><td>403.7</td><td>310.9</td><td>432.7</td></tr><tr><td>5</td><td>–</td><td>60.0</td><td>–</td><td>–</td><td>314.8</td><td>377.8</td><td>414.8</td><td>291.0</td><td>430.7</td></tr><tr><td>50/5</td><td>0</td><td>βˆ’</td><td></td><td>1</td><td>3</td><td></td><td></td><td>270</td><td>279</td><td>437</td></tr></table>
<table><tr><td rowspan="4">0</td><td></td><td>17.7</td><td>–</td><td>70.2</td><td>7.5</td><td>248.2</td><td>259.3</td><td>.4</td><td>.1</td><td>.8</td></tr><tr><td>1</td><td>–</td><td>60.7</td><td>172.4</td><td>9.1</td><td>266.7</td><td>281.5</td><td>307.4</td><td>313.9</td><td>431.5</td></tr><tr><td>3</td><td>–</td><td>57.3</td><td>–</td><td>–</td><td>274.1</td><td>340.7</td><td>388.9</td><td>300.0</td><td>429.5</td></tr><tr><td>5</td><td>–</td><td>58.6</td><td>–</td><td>–</td><td>285.2</td><td>388.9</td><td>425.9</td><td>294.4</td><td>441.0</td></tr><tr><td rowspan="4">70/30</td><td>0</td><td>βˆ’19.3</td><td>–</td><td>173.1</td><td>53.7</td><td>235.2</td><td>242.6</td><td>248.2</td><td>276.9</td><td>414.2</td></tr><tr><td>1</td><td>–</td><td>58.0</td><td>172.8</td><td>18.3</td><td>281.5</td><td>292.6</td><td>300.0</td><td>303.6</td><td>446.7</td></tr><tr><td>3</td><td>–</td><td>57.4</td><td>170.0</td><td>1.9</td><td>274.1</td><td>296.3</td><td>377.8</td><td>297.9</td><td>438.7</td></tr><tr><td>5</td><td>–</td><td>54.3</td><td>–</td><td>–</td><td>266.7</td><td>355.6</td><td>407.4</td><td>284.1</td><td>429.5</td></tr></table>
59a009a39824d69fde93d6109507b32953d59ca1e1159d7c174a3aa793343de1.png
simple
<table><tr><td>Antibiotics Tested</td><td>No. (%) Resistant <sup>a</sup></td></tr><tr><td>Cefoxitin (CX) </td><td>34 (20.12%)</td></tr><tr><td>Cefotaxime (CTX) </td><td>165 (97.63%)</td></tr><tr><td>Ceftazidime (CAZ) </td><td>154 (91.12%)</td></tr><tr><td>Cefpodoxime (CPD)</td><td>156 (92.30%)</td></tr><tr><td>Imipenem (IPM) </td><td>18 (10.65%)</td></tr><tr><td>Ertapenem (ETP) </td><td>69 (40.82%)</td></tr><tr><td>Meropenem (MRP) </td><td>53 (31.36%)</td></tr><tr><td>Ciprofloxacin (CIP)</td><td>27 (15.98%)</td></tr><tr><td>Aztreonam (AT) </td><td>110 (65.08%)</td></tr><tr><td>Amox/clav (AMC) </td><td>65 (38.46%)</td></tr><tr><td>Piperacillin/Tazobactam (TZP) </td><td>69 (40.82%)</td></tr></table>
<table><tr><td>Antibiotics Tested</td><td>No. (%) Resistant a</td></tr><tr><td>Cefoxitin (CX)</td><td>34 (20.12%)</td></tr><tr><td>Cefotaxime (CTX)</td><td>165 (97.63%)</td></tr></table>
<table><tr><td>Antibiotics Tested</td><td>No. (%) Resistant a</td></tr><tr><td>Ceftazidime (CAZ)</td><td>154 (91.12%)</td></tr><tr><td>Cefpodoxime (CPD)</td><td>156 (92.30%)</td></tr><tr><td>Imipenem (IPM)</td><td>18 (10.65%)</td></tr><tr><td>Ertapenem (ETP)</td><td>69 (40.82%)</td></tr><tr><td>Meropenem (MRP)</td><td>53 (31.36%)</td></tr><tr><td>Ciprofloxacin (CIP)</td><td>27 (15.98%)</td></tr><tr><td>Aztreonam (AT)</td><td>110 (65.08%)</td></tr><tr><td>Amox/clav (AMC)</td><td>65 (38.46%)</td></tr><tr><td>Piperacillin/Tazobactam (TZP)</td><td>69 (40.82%)</td></tr></table>
e97995388d0d0628221fdc83c85b8dfe611920f71ce5c7f82ddcd27e2063a5ab.png
complex
<table><tr><td rowspan="2">Smoking groups</td><td colspan="4">Women (<i>n</i> = 1741)</td><td colspan="4">Men (<i>n</i> = 1637)</td><td></td></tr><tr><td><i>n</i></td><td>Median</td><td>5th perc.</td><td>95th perc.</td><td><i>n</i></td><td>Median</td><td>5th perc.</td><td>95th perc.</td><td><i>p</i> value<sup>a</sup></td></tr><tr><td>Never smokers</td><td>868</td><td>15.7</td><td>7.8</td><td>35.7</td><td>817</td><td>19.0</td><td>9.0</td><td>44.2</td><td>&lt;0.0001</td></tr><tr><td>Former smokers</td><td>581</td><td>16.3</td><td>7.6</td><td>35.6</td><td>615</td><td>18.9</td><td>9.2</td><td>39.9</td><td>&lt;0.0001</td></tr><tr><td>Current smokers</td><td>292</td><td>10.4<sup>b</sup></td><td>4.4</td><td>29.4</td><td>205</td><td>13.2 <sup>b</sup></td><td>6.2</td><td>34.3</td><td>&lt;0.0001</td></tr><tr><td>All subjects</td><td>1741</td><td>15.0</td><td>6.6</td><td>35.3</td><td>1637</td><td>18.2</td><td>8.2</td><td>41.3</td><td>&lt;0.001.</td></tr></table>
<table><tr><td rowspan="2">Smoking groups</td><td colspan="4">Women (n = 1741)</td><td colspan="4">Men (n = 1637)</td><td></td></tr><tr><td>n</td><td>Median</td><td>5th perc.</td><td>95th perc.</td><td>n</td><td>Median</td><td>5th perc.</td><td>95th perc.</td><td>p valuea</td></tr><tr><td>Ne</td><td>868</td><td>15.7</td><td>7.8</td><td>3</td><td>8</td><td></td><td>9.0</td><td>44</td><td><</td></tr></table>
<table><tr><td>ver smokers</td><td></td><td></td><td></td><td>5.7</td><td>17</td><td>19.0</td><td></td><td>.2</td><td>0.0001</td></tr><tr><td>Former smokers</td><td>581</td><td>16.3</td><td>7.6</td><td>35.6</td><td>615</td><td>18.9</td><td>9.2</td><td>39.9</td><td><0.0001</td></tr><tr><td>Current smokers</td><td>292</td><td>10.4b</td><td>4.4</td><td>29.4</td><td>205</td><td>13.2 b</td><td>6.2</td><td>34.3</td><td><0.0001</td></tr><tr><td>All subjects</td><td>1741</td><td>15.0</td><td>6.6</td><td>35.3</td><td>1637</td><td>18.2</td><td>8.2</td><td>41.3</td><td><0.001.</td></tr></table>
3b5380e1d8fb6db8612cf0514ae257c35f9e01938fe7fbb52c02addaa1077660.png
complex
<table><tr><td> </td><td colspan="2">Changes between years</td><td colspan="3">Difference in the changes</td><td> </td></tr><tr><td> </td><td>EG</td><td>Non EG</td><td>Mean</td><td colspan="2">95% CI</td><td>Sig.</td></tr><tr><td>2003-2005</td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>HCE as % of total expenditure (%)</td><td>&#8722;0.528</td><td>0.458</td><td>&#8722;0.987</td><td>&#8722;1.651</td><td>&#8722;0.398</td><td>Yes</td></tr><tr><td>Number of self-treatment (#)</td><td>&#8722;0.991</td><td>&#8722;1.094</td><td>0.103</td><td>&#8722;0.157</td><td>0.359</td><td>No</td></tr><tr><td>Number of go-to-pharmacy (#)</td><td>&#8722;0.030</td><td>&#8722;0.046</td><td>0.016</td><td>&#8722;0.099</td><td>0.101</td><td>No</td></tr><tr><td>Number of private health care utilizations (#)</td><td>&#8722;0.188</td><td>&#8722;0.204</td><td>0.016</td><td>&#8722;0.119</td><td>0.149</td><td>No</td></tr><tr><td>Number of CHS utilizations (#)</td><td>0.005</td><td>&#8722;0.046</td><td>0.052</td><td>&#8722;0.025</td><td>0.102</td><td>No</td></tr><tr><td>Number of DH utilizations (#)</td><td>0.016</td><td>0.019</td><td>&#8722;0.003</td><td>&#8722;0.046</td><td>0.033</td><td>No</td></tr><tr><td>Number of P/CH utilizations (#)</td><td>&#8722;0.010</td><td>0.007</td><td>&#8722;0.017</td><td>&#8722;0.042</td><td>0.012</td><td>No</td></tr><tr><td>Total number of utilizations (#)</td><td>&#8722;1.199</td><td>&#8722;1.365</td><td>0.167</td><td>&#8722;0.249</td><td>0.545</td><td>No</td></tr><tr><td>2005-2007</td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>HCE as % of total expenditure (%)</td><td>&#8722;0.065</td><td>0.222</td><td>&#8722;0.287</td><td>&#8722;1.066</td><td>0.560</td><td>No</td></tr><tr><td>Number of self-treatment (#)</td><td>0.196</td><td>&#8722;0.062</td><td>0.258</td><td>&#8722;0.103</td><td>0.484</td><td>No</td></tr><tr><td>Number of go-to-pharmacy (#)</td><td>0.209</td><td>0.182</td><td>0.027</td><td>&#8722;0.083</td><td>0.123</td><td>No</td></tr><tr><td>Number of private health care utilizations (#)</td><td>0.014</td><td>0.021</td><td>&#8722;0.007</td><td>&#8722;0.164</td><td>0.066</td><td>No</td></tr><tr><td>Number of CHS utilizations (#)</td><td>0.016</td><td>0.030</td><td>&#8722;0.013</td><td>&#8722;0.111</td><td>0.053</td><td>No</td></tr><tr><td>Number of DH utilizations (#)</td><td>0.247</td><td>0.269</td><td>&#8722;0.022</td><td>&#8722;0.093</td><td>0.047</td><td>No</td></tr><tr><td>Number of P/CH utilizations (#)</td><td>0.034</td><td>&#8722;0.005</td><td>0.039</td><td>0.016</td><td>0.075</td><td>Yes</td></tr><tr><td>Total number of utilizations (#)</td><td>0.716</td><td>0.434</td><td>0.282</td><td>&#8722;0.350</td><td>0.690</td><td>No</td></tr><tr><td>2003-2007</td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>HCE as % of total expenditure (%)</td><td>&#8722;0.588</td><td>0.640</td><td>&#8722;1.227</td><td>&#8722;2.312</td><td>&#8722;0.724</td><td>Yes</td></tr><tr><td>Number of self-treatment (#)</td><td>&#8722;0.797</td><td>&#8722;1.165</td><td>0.368</td><td>0.067</td><td>0.663</td><td>Yes</td></tr><tr><td>Number of go-to-pharmacy (#)</td><td>0.176</td><td>0.143</td><td>0.033</td><td>&#8722;0.070</td><td>0.124</td><td>No</td></tr><tr><td>Number of private health care utilizations (#)</td><td>&#8722;0.176</td><td>&#8722;0.190</td><td>0.014</td><td>&#8722;0.154</td><td>0.115</td><td>No</td></tr><tr><td>Number of CHS utilizations (#)</td><td>0.023</td><td>&#8722;0.015</td><td>0.038</td><td>&#8722;0.030</td><td>0.123</td><td>No</td></tr><tr><td>Number of DH utilizations (#)</td><td>0.262</td><td>0.280</td><td>&#8722;0.018</td><td>&#8722;0.088</td><td>0.043</td><td>No</td></tr><tr><td>Number of P/CH utilizations (#)</td><td>0.023</td><td>0.002</td><td>0.021</td><td>0.001</td><td>0.051</td><td>Yes</td></tr><tr><td>Total number of utilizations (#)</td><td>&#8722;0.488</td><td>&#8722;0.944</td><td>0.456</td><td>&#8722;0.013</td><td>0.825</td><td>No</td></tr></table>
<table><tr><td></td><td colspan="2">Changes between years</td><td colspan="3">Difference in the changes</td><td></td></tr><tr><td></td><td>EG</td><td>Non EG</td><td>Mean</td><td colspan="2">95% CI</td><td>Sig.</td></tr><tr><td>2003-2005</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>HCE as % of total expenditure (%)</td><td>βˆ’0.528</td><td>0.458</td><td>βˆ’0.987</td><td>βˆ’1.651</td><td>βˆ’0.398</td><td>Yes</td></tr><tr><td>Number of self-treatment (#)</td><td>βˆ’0.991</td><td>βˆ’1.094</td><td>0.103</td><td>βˆ’0.157</td><td>0.359</td><td>No</td></tr><tr><td>Number of go-to-pharmacy (#)</td><td>βˆ’0.030</td><td>βˆ’0.046</td><td>0.016</td><td>βˆ’0.099</td><td>0.101</td><td>No</td></tr><tr><td>Number of private health care utilizations (#)</td><td>βˆ’0.188</td><td>βˆ’0.204</td><td>0.016</td><td>βˆ’0.119</td><td>0.149</td><td>No</td></tr><tr><td>Number of CHS utilizations (#)</td><td>0.005</td><td>βˆ’0.046</td><td>0.052</td><td>βˆ’0.025</td><td>0.102</td><td>No</td></tr><tr><td>Number of DH utilizations (#)</td><td>0.016</td><td>0.019</td><td>βˆ’0.003</td><td>βˆ’0.046</td><td>0.033</td><td>No</td></tr><tr><td>Number of P/CH utilizations (#)</td><td>βˆ’0.010</td><td>0.007</td><td>βˆ’0.017</td><td>βˆ’0.042</td><td>0.012</td><td>No</td></tr><tr><td>Total number of utilizations (#)</td><td>βˆ’1.199</td><td>βˆ’1.365</td><td>0.167</td><td>βˆ’0.249</td><td>0.545</td><td>No</td></tr><tr><td>2005-2007</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>HCE as % of total expenditure (%)</td><td>βˆ’0.065</td><td>0.222</td><td>βˆ’0.287</td><td>βˆ’1.066</td><td>0.560</td><td>No</td></tr><tr><td>Number of self-treatment (#)</td><td>0.196</td><td>βˆ’0.062</td><td>0.258</td><td>βˆ’0.103</td><td>0.484</td><td>No</td></tr><tr><td>Number of go-to-pharmacy (#)</td><td>0.209</td><td>0.182</td><td>0.027</td><td>βˆ’0.083</td><td>0.123</td><td>No</td></tr><tr><td>Number of private health care utilizations (#)</td><td>0.014</td><td>0.021</td><td>βˆ’0.007</td><td>βˆ’0.164</td><td>0.066</td><td>No</td></tr><tr><td>Number of CHS utilizations (#)</td><td>0.016</td><td>0.030</td><td>βˆ’0.013</td><td>βˆ’0.111</td><td>0.053</td><td>No</td></tr><tr><td>Number of DH utilizations (#)</td><td>0.247</td><td>0.269</td><td>βˆ’0.022</td><td>βˆ’0.093</td><td>0.047</td><td>No</td></tr><tr><td>Number of P/CH utilizations (#)</td><td>0.034</td><td>βˆ’0.005</td><td>0.039</td><td>0.016</td><td>0.075</td><td>Yes</td></tr><tr><td>Total number of utilizations (#)</td><td>0.716</td><td>0.434</td><td>0.282</td><td>βˆ’0.350</td><td>0.690</td><td>No</td></tr></table>
<table><tr><td></td><td colspan="2">Changes between years</td><td colspan="3">Difference in the changes</td><td></td></tr><tr><td>2003-2007</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>HCE as % of total expenditure (%)</td><td>βˆ’0.588</td><td>0.640</td><td>βˆ’1.227</td><td>βˆ’2.312</td><td>βˆ’0.724</td><td>Yes</td></tr><tr><td>Number of self-treatment (#)</td><td>βˆ’0.797</td><td>βˆ’1.165</td><td>0.368</td><td>0.067</td><td>0.663</td><td>Yes</td></tr><tr><td>Number of go-to-pharmacy (#)</td><td>0.176</td><td>0.143</td><td>0.033</td><td>βˆ’0.070</td><td>0.124</td><td>No</td></tr><tr><td>Number of private health care utilizations (#)</td><td>βˆ’0.176</td><td>βˆ’0.190</td><td>0.014</td><td>βˆ’0.154</td><td>0.115</td><td>No</td></tr><tr><td>Number of CHS utilizations (#)</td><td>0.023</td><td>βˆ’0.015</td><td>0.038</td><td>βˆ’0.030</td><td>0.123</td><td>No</td></tr><tr><td>Number of DH utilizations (#)</td><td>0.262</td><td>0.280</td><td>βˆ’0.018</td><td>βˆ’0.088</td><td>0.043</td><td>No</td></tr><tr><td>Number of P/CH utilizations (#)</td><td>0.023</td><td>0.002</td><td>0.021</td><td>0.001</td><td>0.051</td><td>Yes</td></tr><tr><td>Total number of utilizations (#)</td><td>βˆ’0.488</td><td>βˆ’0.944</td><td>0.456</td><td>βˆ’0.013</td><td>0.825</td><td>No</td></tr></table>
4d921ce63998537e26c9962f01072e82d1295a0a62953479d7525eb59ec3b850.png
simple
<table><tr><td></td><td>Crude model 1OR (95 % CI)</td><td>Model 2OR (95 % CI)</td><td>Model 3OR (95 % CI)</td><td>Mediating effect of maternal burden of care(%)</td><td>Model 4OR (95 % CI)</td><td>Mediating effectof maternal aggressive behavior(%)</td></tr><tr><td>Overall problem score P80</td><td>3.27 (2.11&#8211;5.07)</td><td>2.12 (1.30&#8211;3.46)</td><td>1.98 (1.21&#8211;3.24)</td><td>12.5 %</td><td>1.90 (1.16&#8211;3.1 2)</td><td>9 %</td></tr><tr><td>Conduct problems P80</td><td>2.25 (1.46&#8211;3.48)</td><td>1.75 (1.09&#8211;2.81)</td><td>1.63 (1.00&#8211;2.62)</td><td>16 %</td><td>1.61 (0.99&#8211;2.56)</td><td>6 %</td></tr><tr><td>Emotional symptoms P80</td><td>2.13 (1.37&#8211;3.34)</td><td>1.54 (0.96&#8211;2.47)</td><td>1.42 (0.88&#8211;2.28)</td><td></td><td>1.41 (0.88&#8211;2.28)</td><td></td></tr><tr><td>Hyperactivity P80</td><td>2.28 (1.47&#8211;3.53)</td><td>1.76 (1.10&#8211;2.82)</td><td>1.75 (1.09&#8211;2.82)</td><td>1 %</td><td>1.72 (1.07&#8211;2.78)</td><td>4 %</td></tr><tr><td>Peer problems P80</td><td>2.55 (1.62&#8211;4.01)</td><td>1.63 (0.79&#8211;2.73)</td><td>1.61 (0.96&#8211;2.70)</td><td></td><td>1.60 (0.95&#8211;2.70)</td><td></td></tr><tr><td>Pro-social P20</td><td>1.74 (1.08&#8211;2.80)</td><td>1.45 (0.87&#8211;2.42)</td><td>1.36 (0.81&#8211;2.28)</td><td></td><td>1.32 (0.79&#8211;2.22)</td><td></td></tr><tr><td>SMFQ P80</td><td>2.62 (1.70&#8211;4.05)</td><td>1.84 (1.14&#8211;2.96)</td><td>1.70 (1.05&#8211;2.74)</td><td>17 %</td><td>1.63 (1.01&#8211;2.65)</td><td>10 %</td></tr><tr><td>Generalized anxiety P80</td><td>1.87 (1.19&#8211;2.92)</td><td>1.25 (0.77&#8211;2.02)</td><td>1.19 (0.74&#8211;1.94)</td><td></td><td>1.17 (0.72&#8211;1.90)</td><td></td></tr></table>
<table><tr><td></td><td>Crude model 1OR (95 % CI)</td><td>Model 2OR (95 % CI)</td><td>Model 3OR (95 % CI)</td><td>Mediating effect of maternal burden of care(%)</td><td>Model 4OR (95 % CI)</td><td>Mediating effectof maternal aggressive behavior(%)</td></tr><tr><td>Overall problem score P80</td><td>3.27 (2.11–5.07)</td><td>2.12 (1.30–3.46)</td><td>1.98 (1.21–3.24)</td><td>12.5 %</td><td>1.90 (1.16–3.1 2)</td><td>9 %</td></tr><tr><td>Conduct problems P80</td><td>2.25 (1.46–3.48)</td><td>1.75 (1.09–2.81)</td><td>1.63 (1.00–2.62)</td><td>16 %</td><td>1.61 (0.99–2.56)</td><td>6 %</td></tr><tr><td>Emotional symptoms P80</td><td>2.13 (1.37–3.34)</td><td>1.54 (0.96–2.47)</td><td>1.42 (0.88–2.28)</td><td></td><td>1.41 (0.88–2.28)</td><td></td></tr></table>
<table><tr><td></td><td>Crude model 1OR (95 % CI)</td><td>Model 2OR (95 % CI)</td><td>Model 3OR (95 % CI)</td><td>Mediating effect of maternal burden of care(%)</td><td>Model 4OR (95 % CI)</td><td>Mediating effectof maternal aggressive behavior(%)</td></tr><tr><td>Hyperactivity P80</td><td>2.28 (1.47–3.53)</td><td>1.76 (1.10–2.82)</td><td>1.75 (1.09–2.82)</td><td>1 %</td><td>1.72 (1.07–2.78)</td><td>4 %</td></tr><tr><td>Peer problems P80</td><td>2.55 (1.62–4.01)</td><td>1.63 (0.79–2.73)</td><td>1.61 (0.96–2.70)</td><td></td><td>1.60 (0.95–2.70)</td><td></td></tr><tr><td>Pro-social P20</td><td>1.74 (1.08–2.80)</td><td>1.45 (0.87–2.42)</td><td>1.36 (0.81–2.28)</td><td></td><td>1.32 (0.79–2.22)</td><td></td></tr><tr><td>SMFQ P80</td><td>2.62 (1.70–4.05)</td><td>1.84 (1.14–2.96)</td><td>1.70 (1.05–2.74)</td><td>17 %</td><td>1.63 (1.01–2.65)</td><td>10 %</td></tr><tr><td>Generalized anxiety P80</td><td>1.87 (1.19–2.92)</td><td>1.25 (0.77–2.02)</td><td>1.19 (0.74–1.94)</td><td></td><td>1.17 (0.72–1.90)</td><td></td></tr></table>
9812e39e9aa3816dbd5f3d8d2d81482bcf83a7e2e13e1a966f4bd0871b4e3627.png
complex
<table><tr><td></td><td>ESI</td><td colspan="2">SRM Transition (<i>m/z</i>&#8594;<i>m/z</i>)</td><td>Collision</td><td>~tR</td></tr><tr><td>Mycotoxin</td><td>(+ or -)</td><td>Quantitative</td><td>Qualitative</td><td>Energy</td><td>(min)</td></tr><tr><td>DON</td><td>-</td><td>341.0&#8594;265.0</td><td>341.0&#8594;247.0</td><td>18</td><td>6.1</td></tr><tr><td>HT2</td><td>+</td><td>442.2&#8594;263.0</td><td>442.2&#8594;215.0</td><td>18</td><td>8.9</td></tr><tr><td>T2</td><td>+</td><td>484.2&#8594;185.0</td><td>484.2&#8594;305.0</td><td>18</td><td>9.3</td></tr><tr><td>ZON</td><td>-</td><td>317.0&#8594;174.5</td><td>317.0&#8594;130.5</td><td>25</td><td>10.1</td></tr><tr><td>FB<sub>1</sub></td><td>+</td><td>722.5&#8594;334.4</td><td>722.5&#8594;352.2</td><td>40</td><td>9.2</td></tr><tr><td>OTA</td><td>+</td><td>404.0&#8594;239.0</td><td>404.0&#8594;358.4</td><td>20</td><td>9.9</td></tr><tr><td>FB<sub>2</sub></td><td>+</td><td>706.4&#8594;336.2</td><td>706.4&#8594;354.2</td><td>35</td><td>10.2</td></tr><tr><td>Meloxicam (IS)</td><td>+</td><td>-</td><td>352.0&#8594;115.0</td><td>20</td><td>8.6/9.1</td></tr></table>
<table><tr><td></td><td>ESI</td><td colspan="2">SRM Transition (m/z→m/z)</td><td>Collision</td><td>~tR</td></tr><tr><td>Mycotoxin</td><td>(+ or -)</td><td>Quantitative</td><td>Qualitative</td><td>Energy</td><td>(min)</td></tr><tr><td>DON</td><td>-</td><td>341.0→265.0</td><td>341.0→247.0</td><td>18</td><td>6.1</td></tr><tr><td>HT2</td><td>+</td><td>442.2→263.0</td><td>442.2→215.0</td><td>18</td><td>8.9</td></tr><tr><td>T2</td><td>+</td><td>484.2→185.0</td><td>484.2→305.0</td><td>18</td><td>9.3</td></tr></table>
<table><tr><td>ZON</td><td>-</td><td>317.0β†’174.5</td><td>317.0β†’130.5</td><td>25</td><td>10.1</td></tr><tr><td>FB1</td><td>+</td><td>722.5β†’334.4</td><td>722.5β†’352.2</td><td>40</td><td>9.2</td></tr><tr><td>OTA</td><td>+</td><td>404.0β†’239.0</td><td>404.0β†’358.4</td><td>20</td><td>9.9</td></tr><tr><td>FB2</td><td>+</td><td>706.4β†’336.2</td><td>706.4β†’354.2</td><td>35</td><td>10.2</td></tr><tr><td>Meloxicam (IS)</td><td>+</td><td>-</td><td>352.0β†’115.0</td><td>20</td><td>8.6/9.1</td></tr></table>
84ef94afab7f0d325ceeb3fd44eb6378e67df6f76e73cb1abd3a41c857a604f3.png
complex
<table><tr><td rowspan="2">OTUs</td><td>Mucus</td><td>Seawater</td><td rowspan="2">OTU contribution (%)b</td><td rowspan="2">Cumulative contribution (%)</td></tr><tr><td>Average abundancea</td><td>Average abundancea</td></tr><tr><td>Unclassified Pseudoalteromonadaceae</td><td>2,203.67</td><td>10,112.13</td><td>21.86</td><td>21.86</td></tr><tr><td>Unclassified Desulfovibrionaceae</td><td>2,253.75</td><td>158.88</td><td>6.01</td><td>27.87</td></tr><tr><td>Unclassified Flavobacteriaceae</td><td>1,396.42</td><td>8.13</td><td>3.64</td><td>31.51</td></tr><tr><td><i>Alteromonas</i></td><td>45.83</td><td>1,417.5</td><td>3.58</td><td>35.1</td></tr><tr><td><i>Ruegeria</i>*</td><td>1,189.92</td><td>372.75</td><td>3.28</td><td>38.38</td></tr><tr><td><i>Vibrio</i></td><td>276.67</td><td>1,247.75</td><td>2.83</td><td>41.21</td></tr><tr><td><i>Pseudoalteromonas</i></td><td>1,090.67</td><td>100.63</td><td>2.76</td><td>43.97</td></tr><tr><td><i>Arcobacter</i></td><td>1,010.17</td><td>2.38</td><td>2.64</td><td>46.61</td></tr><tr><td>Unclassified Desulfobulbaceae</td><td>847.92</td><td>1.25</td><td>2.22</td><td>48.82</td></tr><tr><td>Unclassified Desulfovibrionaceae</td><td>825.17</td><td>41.25</td><td>2.19</td><td>51.02</td></tr><tr><td><i>Idiomarina</i></td><td>76.58</td><td>817.13</td><td>2.17</td><td>53.18</td></tr><tr><td>Unclassified Rhodobacteraceae</td><td>910.33</td><td>276.5</td><td>2.15</td><td>55.34</td></tr><tr><td>Unclassified Hyphomonadaceae</td><td>804.17</td><td>2.75</td><td>2.1</td><td>57.44</td></tr><tr><td><i>Halomonas</i></td><td>560.92</td><td>122.13</td><td>1.64</td><td>59.08</td></tr><tr><td><i>Thalassospira</i></td><td>563.33</td><td>69.25</td><td>1.56</td><td>60.64</td></tr><tr><td><i>Alcanivorax</i></td><td>18.42</td><td>600.38</td><td>1.53</td><td>62.16</td></tr><tr><td><i>Marinobacter</i></td><td>10.92</td><td>543.63</td><td>1.41</td><td>63.57</td></tr><tr><td>Unclassified Vibrionaceae</td><td>613.17</td><td>153.75</td><td>1.28</td><td>64.85</td></tr><tr><td>Unclassified Acidaminobacteraceae</td><td>476.67</td><td>0</td><td>1.25</td><td>66.09</td></tr><tr><td>Unclassified Flavobacteriaceae</td><td>398.25</td><td>15.75</td><td>1.03</td><td>67.13</td></tr><tr><td><i>Oceanicaulis</i></td><td>317</td><td>141.38</td><td>0.97</td><td>68.1</td></tr><tr><td><i>Idiomarina</i></td><td>35.08</td><td>389</td><td>0.92</td><td>69.02</td></tr><tr><td><i>Marinobacter</i></td><td>0.17</td><td>334.25</td><td>0.87</td><td>69.9</td></tr><tr><td colspan="5"><i>Phylum</i></td></tr><tr><td>Proteobacteria</td><td></td><td></td><td>63.97</td><td>63.97</td></tr><tr><td>Firmicutes</td><td></td><td></td><td>1.25</td><td>65.22</td></tr><tr><td>Bacteriodetes</td><td></td><td></td><td>4.67</td><td>69.89</td></tr></table>
<table><tr><td rowspan="2">OTUs</td><td>Mucus</td><td>Seawater</td><td rowspan="2">OTU contribution (%)b</td><td rowspan="2">Cumulative contribution (%)</td></tr><tr><td>Average abundancea</td><td>Average abundancea</td></tr><tr><td>Unclassified Pseudoalteromonadaceae</td><td>2,203.67</td><td>10,112.13</td><td>21.86</td><td>21.86</td></tr><tr><td>Unclassified Desulfovibrionaceae</td><td>2,253.75</td><td>158.88</td><td>6.01</td><td>27.87</td></tr><tr><td>Unclassified Flavobacteriaceae</td><td>1,396.42</td><td>8.13</td><td>3.64</td><td>31.51</td></tr><tr><td>Alteromonas</td><td>45.83</td><td>1,417.5</td><td>3.58</td><td>35.1</td></tr><tr><td>Ruegeria*</td><td>1,189.92</td><td>372.75</td><td>3.28</td><td>38.38</td></tr><tr><td>Vibrio</td><td>276.67</td><td>1,247.75</td><td>2.83</td><td>41.21</td></tr><tr><td>Pseudoalteromonas</td><td>1,090.67</td><td>100.63</td><td>2.76</td><td>43.97</td></tr><tr><td>Arcobacter</td><td>1,010.17</td><td>2.38</td><td>2.64</td><td>46.61</td></tr></table>
<table><tr><td>Unclassified Desulfobulbaceae</td><td>847.92</td><td>1.25</td><td>2.22</td><td>48.82</td></tr><tr><td>Unclassified Desulfovibrionaceae</td><td>825.17</td><td>41.25</td><td>2.19</td><td>51.02</td></tr><tr><td>Idiomarina</td><td>76.58</td><td>817.13</td><td>2.17</td><td>53.18</td></tr><tr><td>Unclassified Rhodobacteraceae</td><td>910.33</td><td>276.5</td><td>2.15</td><td>55.34</td></tr><tr><td>Unclassified Hyphomonadaceae</td><td>804.17</td><td>2.75</td><td>2.1</td><td>57.44</td></tr><tr><td>Halomonas</td><td>560.92</td><td>122.13</td><td>1.64</td><td>59.08</td></tr><tr><td>Thalassospira</td><td>563.33</td><td>69.25</td><td>1.56</td><td>60.64</td></tr><tr><td>Alcanivorax</td><td>18.42</td><td>600.38</td><td>1.53</td><td>62.16</td></tr><tr><td>Marinobacter</td><td>10.92</td><td>543.63</td><td>1.41</td><td>63.57</td></tr><tr><td>Unclassified Vibrionaceae</td><td>613.17</td><td>153.75</td><td>1.28</td><td>64.85</td></tr><tr><td>Unclassified Acidaminobacteraceae</td><td>476.67</td><td>0</td><td>1.25</td><td>66.09</td></tr><tr><td>Unclassified Flavobacteriaceae</td><td>398.25</td><td>15.75</td><td>1.03</td><td>67.13</td></tr><tr><td>Oceanicaulis</td><td>317</td><td>141.38</td><td>0.97</td><td>68.1</td></tr><tr><td>Idiomarina</td><td>35.08</td><td>389</td><td>0.92</td><td>69.02</td></tr><tr><td>Marinobacter</td><td>0.17</td><td>334.25</td><td>0.87</td><td>69.9</td></tr><tr><td colspan="5">Phylum</td></tr><tr><td>Proteobacteria</td><td></td><td></td><td>63.97</td><td>63.97</td></tr><tr><td>Firmicutes</td><td></td><td></td><td>1.25</td><td>65.22</td></tr><tr><td>Bacteriodetes</td><td></td><td></td><td>4.67</td><td>69.89</td></tr></table>
31511de482299c342adf8e815a372d644123709080b331abaab46833e473818b.png
simple
<table><tr><td><i>Nocardia</i> spp. (no. of strains)</td><td>Agreement between 16S and MALDI-TOF MS</td><td>No. of strains in the Bruker database</td></tr><tr><td>High prevalence (<i>n</i> = 25)</td><td></td><td></td></tr><tr><td><i>Nocardia abscessus</i> (<i>n</i> = 2)</td><td>2/2</td><td>2</td></tr><tr><td><i>N. cyriacigeorgica</i> (<i>n</i> = 6)</td><td>5/6</td><td>16</td></tr><tr><td><i>N. farcinica</i> (<i>n</i> = 8)</td><td>7/8</td><td>12</td></tr><tr><td><i>N. nova</i> (<i>n</i> = 9)</td><td>5/9</td><td>2</td></tr><tr><td>Total (%)</td><td>19/25 (76.0%)</td><td>32</td></tr><tr><td>Intermediate prevalence (<i>n</i> = 20)</td><td></td><td></td></tr><tr><td><i>N. brasiliensis</i> (<i>n</i> = 5)</td><td>3/5</td><td>1</td></tr><tr><td><i>N. carnea</i> (<i>n</i> = 7)</td><td>1/7</td><td>1</td></tr><tr><td><i>N. otitidiscaviarum</i> (<i>n</i> = 5)</td><td>5/5</td><td>6</td></tr><tr><td><i>N. transvalensis</i> complex (<i>n</i> = 3)</td><td>0/3</td><td>1</td></tr><tr><td>Total (%)</td><td>9/20 (45%)</td><td>9</td></tr><tr><td>Low prevalence (<i>n</i> = 55)</td><td></td><td></td></tr><tr><td>22 <i>Nocardia</i> species:</td><td>5/55</td><td>45</td></tr><tr><td>-13 <i>Nocardia</i> species included in Bruker database (<i>n</i> = 28)</td><td>5/23</td><td>45</td></tr><tr><td>-9 <i>Nocardia</i> species not included in Bruker database (<i>n</i> = 27)</td><td>0</td><td>0</td></tr><tr><td>Total (%)</td><td>5/55 (9.1%)</td><td>45</td></tr></table>
<table><tr><td>Nocardia spp. (no. of strains)</td><td>Agreement between 16S and MALDI-TOF MS</td><td>No. of strains in the Bruker database</td></tr><tr><td>High prevalence (n = 25)</td><td></td><td></td></tr><tr><td>Nocardia abscessus (n = 2)</td><td>2/2</td><td>2</td></tr></table>
<table><tr><td>N. cyriacigeorgica (n = 6)</td><td>5/6</td><td>16</td></tr><tr><td>N. farcinica (n = 8)</td><td>7/8</td><td>12</td></tr><tr><td>N. nova (n = 9)</td><td>5/9</td><td>2</td></tr><tr><td>Total (%)</td><td>19/25 (76.0%)</td><td>32</td></tr><tr><td>Intermediate prevalence (n = 20)</td><td></td><td></td></tr><tr><td>N. brasiliensis (n = 5)</td><td>3/5</td><td>1</td></tr><tr><td>N. carnea (n = 7)</td><td>1/7</td><td>1</td></tr><tr><td>N. otitidiscaviarum (n = 5)</td><td>5/5</td><td>6</td></tr><tr><td>N. transvalensis complex (n = 3)</td><td>0/3</td><td>1</td></tr><tr><td>Total (%)</td><td>9/20 (45%)</td><td>9</td></tr><tr><td>Low prevalence (n = 55)</td><td></td><td></td></tr><tr><td>22 Nocardia species:</td><td>5/55</td><td>45</td></tr><tr><td>-13 Nocardia species included in Bruker database (n = 28)</td><td>5/23</td><td>45</td></tr><tr><td>-9 Nocardia species not included in Bruker database (n = 27)</td><td>0</td><td>0</td></tr><tr><td>Total (%)</td><td>5/55 (9.1%)</td><td>45</td></tr></table>
ecfd8e38fb12f9ea5eb444d8067e9694527cc39be0a16d9ee491b052e6cf56bc.png
simple
<table><tr><td>Diagnosis</td><td>Indication</td><td>Type of procedure</td></tr><tr><td>HLHS</td><td>Trans-isthmus gradient &gt; 20 mmHg</td><td>Balloon angioplasty</td></tr><tr><td>DILV</td><td>SVC-LPA 2 mmHg gradient</td><td>LPA balloon angioplasty</td></tr><tr><td>TA</td><td>Significant LPA stenosis at X-ray angiography</td><td>LPA balloon angioplasty</td></tr><tr><td>PAIVS</td><td>Veno-venous collateral draining into the CS</td><td>Embolization</td></tr><tr><td>TA</td><td>Veno-venous collateral draining into the atrium</td><td>Embolization</td></tr><tr><td>Complex 2 ventricles</td><td>BTm shunt center opened at previous surgery</td><td>Embolization</td></tr></table>
<table><tr><td>Diagnosis</td><td>Indication</td><td>Type of procedure</td></tr><tr><td>HLHS</td><td>Trans-isthmus gradient > 20 mmHg</td><td>Balloon angioplasty</td></tr></table>
<table><tr><td>DILV</td><td>SVC-LPA 2 mmHg gradient</td><td>LPA balloon angioplasty</td></tr><tr><td>TA</td><td>Significant LPA stenosis at X-ray angiography</td><td>LPA balloon angioplasty</td></tr><tr><td>PAIVS</td><td>Veno-venous collateral draining into the CS</td><td>Embolization</td></tr><tr><td>TA</td><td>Veno-venous collateral draining into the atrium</td><td>Embolization</td></tr><tr><td>Complex 2 ventricles</td><td>BTm shunt center opened at previous surgery</td><td>Embolization</td></tr></table>
41baf412fb3ded9de715031eaf1d56cd87dae40be491e5cf583d25e409e0948c.png
complex
<table><tr><td></td><td colspan="4">Likelihood</td></tr><tr><td>Covariate</td><td>WHO</td><td>Int 1</td><td>Int 2</td><td>Exact</td></tr><tr><td>Age (centered at 40 in y)</td><td>0.968 (0.966&#8211;0.970)</td><td>0.969 (0.967&#8211;0.971)</td><td>0.968 (0.967&#8211;0.970)</td><td>0.968 (0.967&#8211;0.970)</td></tr><tr><td>Alcohol intake (g/d)</td><td>1.002 (0.999&#8211;1.004)</td><td>1.003 (1.001&#8211;1.005)</td><td>1.003 (1.001&#8211;1.004)</td><td>1.002 (1.001&#8211;1.004)</td></tr><tr><td>Fruit and vegetables</td><td></td><td></td><td></td><td></td></tr><tr><td>High</td><td>1</td><td>1</td><td>1</td><td>1</td></tr><tr><td>Low</td><td>0.880 (0.824&#8211;0.940)</td><td>0.928 (0.874&#8211;0.986)</td><td>0.929 (0.878&#8211;0.983)</td><td>0.929 (0.878&#8211;0.983)</td></tr><tr><td>Physical activity</td><td></td><td></td><td></td><td></td></tr><tr><td>High</td><td>1</td><td>1</td><td>1</td><td>1</td></tr><tr><td>Moderate</td><td>0.836 (0.774&#8211;0.903)</td><td>0.850 (0.792&#8211;0.912)</td><td>0.863 (0.808&#8211;0.921)</td><td>0.862 (0.808&#8211;0.921)</td></tr><tr><td>Low</td><td>0.695 (0.640&#8211;0.756)</td><td>0.743 (0.688&#8211;0.802)</td><td>0.769 (0.716&#8211;0.827)</td><td>0.769 (0.716&#8211;0.826)</td></tr><tr><td>Education</td><td></td><td></td><td></td><td></td></tr><tr><td>Mandatory</td><td>1</td><td>1</td><td>1</td><td>1</td></tr><tr><td>Secondary</td><td>1.095 (0.992&#8211;1.209)</td><td>1.252 (1.141&#8211;1.373)</td><td>1.256 (1.150&#8211;1.371)</td><td>1.254 (1.149&#8211;1.369)</td></tr><tr><td>Tertiary</td><td>1.604 (1.441&#8211;1.786)</td><td>1.760 (1.594&#8211;1.944)</td><td>1.785 (1.625&#8211;1.961)</td><td>1.781 (1.622&#8211;1.956)</td></tr><tr><td>Nationality</td><td></td><td></td><td></td><td></td></tr><tr><td>Swiss</td><td>1</td><td>1</td><td>1</td><td>1</td></tr><tr><td>Foreign</td><td>0.785 (0.728&#8211;0.848)</td><td>0.832 (0.776&#8211;0.893)</td><td>0.810 (0.758&#8211;0.864)</td><td>0.809 (0.758&#8211;0.864)</td></tr><tr><td>Region</td><td></td><td></td><td></td><td></td></tr><tr><td>German speaking</td><td>1</td><td>1</td><td>1</td><td>1</td></tr><tr><td>French speaking</td><td>1.175 (1.091&#8211;1.266)</td><td>1.147 (1.071&#8211;1.228)</td><td>1.134 (1.063&#8211;1.208)</td><td>1.133 (1.063&#8211;1.208)</td></tr><tr><td>Italian speaking</td><td>1.190 (1.026&#8211;1.382)</td><td>1.173 (1.024&#8211;1.344)</td><td>1.236 (1.086&#8211;1.405)</td><td>1.234 (1.085&#8211;1.403)</td></tr></table>
<table><tr><td></td><td colspan="4">Likelihood</td></tr><tr><td>Covariate</td><td>WHO</td><td>Int 1</td><td>Int 2</td><td>Exact</td></tr><tr><td>Age (centered at 40 in y)</td><td>0.968 (0.966–0.970)</td><td>0.969 (0.967–0.971)</td><td>0.968 (0.967–0.970)</td><td>0.968 (0.967–0.970)</td></tr><tr><td>Alcohol intake (g/d)</td><td>1.002 (0.999–1.004)</td><td>1.003 (1.001–1.005)</td><td>1.003 (1.001–1.004)</td><td>1.002 (1.001–1.004)</td></tr><tr><td>Fruit and vegetables</td><td></td><td></td><td></td><td></td></tr><tr><td>High</td><td>1</td><td>1</td><td>1</td><td>1</td></tr><tr><td>Low</td><td>0.880 (0.824–0.940)</td><td>0.928 (0.874–0.986)</td><td>0.929 (0.878–0.983)</td><td>0.929 (0.878–0.983)</td></tr><tr><td>Physical activity</td><td></td><td></td><td></td><td></td></tr><tr><td>High</td><td>1</td><td>1</td><td>1</td><td>1</td></tr><tr><td>Moderate</td><td>0.836 (0.774–0.903)</td><td>0.850 (0.792–0.912)</td><td>0.863 (0.808–0.921)</td><td>0.862 (0.808–0.921)</td></tr><tr><td>Low</td><td>0.695 (0.640–0.756)</td><td>0.743 (0.688–0.802)</td><td>0.769 (0.716–0.827)</td><td>0.769 (0.716–0.826)</td></tr><tr><td>Education</td><td></td><td></td><td></td><td></td></tr><tr><td>Mandatory</td><td>1</td><td>1</td><td>1</td><td>1</td></tr></table>
<table><tr><td></td><td colspan="4">Likelihood</td></tr><tr><td>Covariate</td><td>WHO</td><td>Int 1</td><td>Int 2</td><td>Exact</td></tr><tr><td>Secondary</td><td>1.095 (0.992–1.209)</td><td>1.252 (1.141–1.373)</td><td>1.256 (1.150–1.371)</td><td>1.254 (1.149–1.369)</td></tr><tr><td>Tertiary</td><td>1.604 (1.441–1.786)</td><td>1.760 (1.594–1.944)</td><td>1.785 (1.625–1.961)</td><td>1.781 (1.622–1.956)</td></tr><tr><td>Nationality</td><td></td><td></td><td></td><td></td></tr><tr><td>Swiss</td><td>1</td><td>1</td><td>1</td><td>1</td></tr><tr><td>Foreign</td><td>0.785 (0.728–0.848)</td><td>0.832 (0.776–0.893)</td><td>0.810 (0.758–0.864)</td><td>0.809 (0.758–0.864)</td></tr><tr><td>Region</td><td></td><td></td><td></td><td></td></tr><tr><td>German speaking</td><td>1</td><td>1</td><td>1</td><td>1</td></tr><tr><td>French speaking</td><td>1.175 (1.091–1.266)</td><td>1.147 (1.071–1.228)</td><td>1.134 (1.063–1.208)</td><td>1.133 (1.063–1.208)</td></tr><tr><td>Italian speaking</td><td>1.190 (1.026–1.382)</td><td>1.173 (1.024–1.344)</td><td>1.236 (1.086–1.405)</td><td>1.234 (1.085–1.403)</td></tr></table>
33aaaa7b0ae915a951b09a1592282859fcaec3953014b3f6e862f3e89cac8097.png
complex
<table><tr><td></td><td colspan="2">Total</td><td colspan="2">SPM-Free</td><td colspan="2">SPM</td><td>P-values<sup>c</sup></td></tr><tr><td>Variable</td><td>No.</td><td>%</td><td>No.</td><td>%</td><td>No.</td><td>%</td><td></td></tr><tr><td>Total patients</td><td>1,292</td><td>100</td><td>1,172</td><td>100</td><td>120</td><td>100</td><td></td></tr><tr><td>Age</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> &#8804; median (57 years)</td><td>668</td><td>51.7</td><td>629</td><td>53.7</td><td>39</td><td>32.5</td><td>&lt; 0.001</td></tr><tr><td> &gt; median (57 years)</td><td>624</td><td>48.3</td><td>543</td><td>46.3</td><td>81</td><td>67.5</td><td></td></tr><tr><td>Sex</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> Male</td><td>981</td><td>75.9</td><td>887</td><td>75.7</td><td>94</td><td>78.3</td><td>0.518</td></tr><tr><td> Female</td><td>311</td><td>24.1</td><td>285</td><td>24.3</td><td>26</td><td>21.7</td><td></td></tr><tr><td>Ethnicity</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> Non-Hispanic White</td><td>1,093</td><td>84.6</td><td>999</td><td>85.2</td><td>94</td><td>78.3</td><td>0.050</td></tr><tr><td> Other</td><td>199</td><td>15.4</td><td>173</td><td>14.8</td><td>26</td><td>21.7</td><td></td></tr><tr><td>Smoking</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> Never</td><td>346</td><td>26.8</td><td>321</td><td>27.4</td><td>25</td><td>20.8</td><td>0.122</td></tr><tr><td> Ever</td><td>946</td><td>73.2</td><td>851</td><td>72.6</td><td>95</td><td>79.2</td><td></td></tr><tr><td>Alcohol</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> Never</td><td>337</td><td>26.1</td><td>310</td><td>26.4</td><td>27</td><td>22.5</td><td>0.348</td></tr><tr><td> Ever</td><td>955</td><td>73.9</td><td>862</td><td>73.6</td><td>93</td><td>77.5</td><td></td></tr><tr><td>Index Cancer Site</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> Oral cavity</td><td>420</td><td>32.5</td><td>382</td><td>32.6</td><td>38</td><td>31.7</td><td>0.320</td></tr><tr><td> Oropharynx</td><td>575</td><td>44.5</td><td>527</td><td>45.0</td><td>48</td><td>40.0</td><td></td></tr><tr><td> Larynx/Hypopharynx</td><td>297</td><td>23.0</td><td>263</td><td>22.4</td><td>34</td><td>28.3</td><td></td></tr><tr><td>Index Cancer Stage</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> I or II</td><td>327</td><td>25.3</td><td>295</td><td>25.0</td><td>32</td><td>26.7</td><td>0.720</td></tr><tr><td> III or IV</td><td>965</td><td>74.7</td><td>877</td><td>75.0</td><td>88</td><td>73.3</td><td></td></tr><tr><td>Treatment</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> Surgery only</td><td>230</td><td>17.8</td><td>209</td><td>17.8</td><td>21</td><td>17.5</td><td>0.894</td></tr><tr><td> Surgery + Adjuvant Tx<sup>a</sup></td><td>322</td><td>24.9</td><td>289</td><td>24.7</td><td>33</td><td>27.5</td><td></td></tr><tr><td> XRT<sup>b</sup></td><td>330</td><td>25.6</td><td>302</td><td>25.8</td><td>28</td><td>23.3</td><td></td></tr><tr><td> XRT + Chemotherapy</td><td>410</td><td>31.7</td><td>372</td><td>31.7</td><td>38</td><td>31.7</td><td></td></tr></table>
<table><tr><td></td><td colspan="2">Total</td><td colspan="2">SPM-Free</td><td colspan="2">SPM</td><td>P-valuesc</td></tr><tr><td>Variable</td><td>No.</td><td>%</td><td>No.</td><td>%</td><td>No.</td><td>%</td><td></td></tr></table>
<table><tr><td>Total patients</td><td>1,292</td><td>100</td><td>1,172</td><td>100</td><td>120</td><td>100</td><td></td></tr><tr><td>Age</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>≀ median (57 years)</td><td>668</td><td>51.7</td><td>629</td><td>53.7</td><td>39</td><td>32.5</td><td>< 0.001</td></tr><tr><td>> median (57 years)</td><td>624</td><td>48.3</td><td>543</td><td>46.3</td><td>81</td><td>67.5</td><td></td></tr><tr><td>Sex</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Male</td><td>981</td><td>75.9</td><td>887</td><td>75.7</td><td>94</td><td>78.3</td><td>0.518</td></tr><tr><td>Female</td><td>311</td><td>24.1</td><td>285</td><td>24.3</td><td>26</td><td>21.7</td><td></td></tr><tr><td>Ethnicity</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Non-Hispanic White</td><td>1,093</td><td>84.6</td><td>999</td><td>85.2</td><td>94</td><td>78.3</td><td>0.050</td></tr><tr><td>Other</td><td>199</td><td>15.4</td><td>173</td><td>14.8</td><td>26</td><td>21.7</td><td></td></tr><tr><td>Smoking</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Never</td><td>346</td><td>26.8</td><td>321</td><td>27.4</td><td>25</td><td>20.8</td><td>0.122</td></tr><tr><td>Ever</td><td>946</td><td>73.2</td><td>851</td><td>72.6</td><td>95</td><td>79.2</td><td></td></tr><tr><td>Alcohol</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Never</td><td>337</td><td>26.1</td><td>310</td><td>26.4</td><td>27</td><td>22.5</td><td>0.348</td></tr><tr><td>Ever</td><td>955</td><td>73.9</td><td>862</td><td>73.6</td><td>93</td><td>77.5</td><td></td></tr><tr><td>Index Cancer Site</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Oral cavity</td><td>420</td><td>32.5</td><td>382</td><td>32.6</td><td>38</td><td>31.7</td><td>0.320</td></tr><tr><td>Oropharynx</td><td>575</td><td>44.5</td><td>527</td><td>45.0</td><td>48</td><td>40.0</td><td></td></tr><tr><td>Larynx/Hypopharynx</td><td>297</td><td>23.0</td><td>263</td><td>22.4</td><td>34</td><td>28.3</td><td></td></tr><tr><td>Index Cancer Stage</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>I or II</td><td>327</td><td>25.3</td><td>295</td><td>25.0</td><td>32</td><td>26.7</td><td>0.720</td></tr><tr><td>III or IV</td><td>965</td><td>74.7</td><td>877</td><td>75.0</td><td>88</td><td>73.3</td><td></td></tr><tr><td>Treatment</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Surgery only</td><td>230</td><td>17.8</td><td>209</td><td>17.8</td><td>21</td><td>17.5</td><td>0.894</td></tr><tr><td>Surgery + Adjuvant Txa</td><td>322</td><td>24.9</td><td>289</td><td>24.7</td><td>33</td><td>27.5</td><td></td></tr><tr><td>XRTb</td><td>330</td><td>25.6</td><td>302</td><td>25.8</td><td>28</td><td>23.3</td><td></td></tr><tr><td>XRT + Chemotherapy</td><td>410</td><td>31.7</td><td>372</td><td>31.7</td><td>38</td><td>31.7</td><td></td></tr></table>
88356c7da2583e349546c0ff4dd33f71ceb68cf154084b2919e9e9cd7e99ca5a.png
simple
<table><tr><td> </td><td>Equations for lean mass estimation (kg)</td><td>Equation number</td><td><i>r</i><sup><i>2</i></sup></td><td>Cp</td><td>p</td><td>RMSE (kg)</td></tr><tr><td>M (n = 24)</td><td>0.3BW + 3.0PC/TC &#8211; 0.003BW/RTL + 3.51</td><td>13</td><td>0.92</td><td>2.31</td><td>=0.04</td><td>0.16</td></tr><tr><td>F (n = 24)</td><td>&#8722;0.003BW/RTL + 0.11BL<sup>2</sup>/R + 0.40</td><td>14</td><td>0.83</td><td>0.45</td><td>=0.04</td><td>0.17</td></tr><tr><td>M and F (n = 48)</td><td>0.2BW + 0.09BL<sup>2</sup>/R + 0.25</td><td>15</td><td>0.85</td><td>4.72</td><td>=0.0001</td><td>0.21</td></tr><tr><td> </td><td>0.04 BW + 0.07 BL<sup>2</sup>/R &#8211; 3.7SFLT + 0.17</td><td>16</td><td>0.87</td><td>2.65</td><td>=0.05</td><td>0.20</td></tr><tr><td>T0 (n = 16)</td><td>0.4BW + 0.08BL<sup>2</sup>/R - 0.05</td><td>17</td><td>0.86</td><td>4.23</td><td>=0.05</td><td>0.22</td></tr><tr><td>T1 (n = 16)</td><td>0.3BW + 0.08BL<sup>2</sup>/R + 0.20</td><td>18</td><td>0.87</td><td>6.40</td><td>=0.02</td><td>0.17</td></tr><tr><td>T2 (n = 16)</td><td>0.3BW &#8211; 2.71PC/TC &#8211; 0.004BW/RTL + 0.05BL<sup>2</sup>/R + 2.73</td><td>19</td><td>0.97</td><td>3.09</td><td>=0.02</td><td>0.10</td></tr></table>
<table><tr><td></td><td>Equations for lean mass estimation (kg)</td><td>Equation number</td></tr><tr><td>M (n = 24)</td><td>0.3BW + 3.0PC/TC – 0.003BW/RTL + 3.51</td><td>13</td></tr><tr><td>F (n = 24)</td><td>βˆ’0.003BW/RTL + 0.11BL2/R + 0.40</td><td>14</td></tr><tr><td>M and F (n = 48)</td><td>0.2BW + 0.09BL2/R + 0.25</td><td>15</td></tr><tr><td></td><td>0.04 BW + 0.07 BL2/R – 3.7SFLT + 0.17</td><td>16</td></tr><tr><td>T0 (n = 16)</td><td>0.4BW + 0.08BL2/R - 0.05</td><td>17</td></tr><tr><td>T1 (n = 16)</td><td>0.3BW + 0.08BL2/R + 0.20</td><td>18</td></tr><tr><td>T2 (n = 16)</td><td>0.3BW – 2.71PC/TC – 0.004BW/RTL + 0.05BL2/R + 2.73</td><td>19</td></tr></table>
<table><tr><td>r2</td><td>Cp</td><td>p</td><td>RMSE (kg)</td></tr><tr><td>0.92</td><td>2.31</td><td>=0.04</td><td>0.16</td></tr><tr><td>0.83</td><td>0.45</td><td>=0.04</td><td>0.17</td></tr><tr><td>0.85</td><td>4.72</td><td>=0.0001</td><td>0.21</td></tr><tr><td>0.87</td><td>2.65</td><td>=0.05</td><td>0.20</td></tr><tr><td>0.86</td><td>4.23</td><td>=0.05</td><td>0.22</td></tr><tr><td>0.87</td><td>6.40</td><td>=0.02</td><td>0.17</td></tr><tr><td>0.97</td><td>3.09</td><td>=0.02</td><td>0.10</td></tr></table>
91eba2bdc3a87cd5e58acd1383285f244a5aadd177187eb2129887423cb1b01f.png
simple
<table><tr><td>Variable</td><td>OR (95% CI)</td><td><i>p</i>-value</td></tr><tr><td>With Shared Epitope</td><td>0.7 (0.3&#8211;1.3)</td><td>0.25</td></tr><tr><td>No Shared Epitope</td><td>0.9 (0.3&#8211;2.6)</td><td>0.90</td></tr><tr><td>Duration &gt; 10</td><td>0.9 (0.4&#8211;1.9)</td><td>0.75</td></tr><tr><td>Duration &lt; 10</td><td>0.8 (0.3&#8211;2.0)</td><td>0.66</td></tr></table>
<table><tr><td>Variable</td><td>OR (95% CI)</td><td>p-value</td></tr><tr><td>With Shared Epitope</td><td>0.7 (0.3–1.3)</td><td>0.25</td></tr></table>
<table><tr><td>No Shared Epitope</td><td>0.9 (0.3–2.6)</td><td>0.90</td></tr><tr><td>Duration > 10</td><td>0.9 (0.4–1.9)</td><td>0.75</td></tr><tr><td>Duration < 10</td><td>0.8 (0.3–2.0)</td><td>0.66</td></tr></table>
8b4788bb598d6c5b30eb98b5423311ba33286460f933ca173cf89f0e340ba7c5.png
complex
<table><tr><td>Patient Characteristic</td><td><i>Plasmodium knowlesi</i></td><td><i>Plasmodium vivax</i></td><td><i>Plasmodium falciparum</i></td><td><i>P</i> Value</td></tr><tr><td>Children (age &#8804;12 y), No. (% total)</td><td>44 (9.1)</td><td>71 (41.3)</td><td>31 (32.3)</td><td>&lt;.001</td></tr><tr><td colspan="5">Age, y</td></tr><tr><td> Median (IQR)</td><td>8 (5&#8211;10)</td><td>9 (5&#8211;10)</td><td>7 (3&#8211;10)</td><td>.095</td></tr><tr><td> Range</td><td>0.1&#8211;12</td><td>0.67&#8211;12</td><td>1&#8211;12</td><td></td></tr><tr><td>Male sex, No. (%)</td><td>25 (56.8)</td><td>34 (47.9)</td><td>21 (67.7)</td><td>.170</td></tr><tr><td>Previous malaria (self-reported), No. (%)</td><td>4 (9.1)</td><td>11 (15.5)</td><td>3 (9.7)</td><td>.526</td></tr><tr><td>History of chronic disease, No. (%)</td><td>2 (4.5)</td><td>0</td><td>0</td><td>.095</td></tr><tr><td>Days of fever</td><td>5 (3&#8211;7)</td><td>5 (3&#8211;7)</td><td>4 (3&#8211;5)</td><td>.751</td></tr><tr><td colspan="5">Symptoms on enrollment, No. (%)</td></tr><tr><td> Rigors</td><td>29 (65.9)</td><td>55 (77.5)</td><td>14 (45.2)</td><td>.006</td></tr><tr><td> Headache</td><td>34 (77.3)</td><td>55 (77.5)</td><td>21 (67.7)</td><td>.542</td></tr><tr><td> Vomiting</td><td>14 (31.8)</td><td>37 (52.1)</td><td>11 (35.5)</td><td>.068</td></tr><tr><td> Abdominal pain</td><td>19 (43.2)</td><td>9 (12.7)</td><td>9 (29.0)</td><td>.001</td></tr><tr><td> Diarrhea</td><td>4 (9.1)</td><td>2 (2.8)</td><td>4 (12.9)</td><td>.140</td></tr><tr><td> Cough</td><td>15 (34.1)</td><td>25 (35.2)</td><td>12 (38.7)</td><td>.914</td></tr><tr><td> Shortness of breath</td><td>3 (6.8)</td><td>4 (5.6)</td><td>4 (12.9)</td><td>.431</td></tr><tr><td> Myalgia</td><td>11 (25.0)</td><td>15 (21.1)</td><td>7 (22.6)</td><td>.890</td></tr><tr><td> Arthralgia</td><td>12 (27.3)</td><td>15 (21.1)</td><td>7 (22.6)</td><td>.746</td></tr><tr><td colspan="5">Examination findings on enrollment</td></tr><tr><td> Temperature, &#176;C</td><td>37.1 (36.8&#8211;37.9)</td><td>37.4 (36.8&#8211;37.8)</td><td>37.1 (36.8&#8211;38)</td><td>.647</td></tr><tr><td> Fever (&#8805;37.5&#176;C), No. (%)</td><td>17 (38.6)</td><td>33 (46.5)</td><td>12 (38.7)</td><td>.634</td></tr><tr><td> Systolic blood pressure, mm Hg</td><td>101 (94&#8211;109)</td><td>102 (96&#8211;110)</td><td>106 (98&#8211;112)</td><td>.356</td></tr><tr><td> Heart rate, beats/min</td><td>104 (93&#8211;119)</td><td>105 (94&#8211;118)</td><td>117 (96&#8211;134)</td><td>.688</td></tr><tr><td> Respiratory rate, breaths/min</td><td>24 (22&#8211;27)</td><td>24 (22&#8211;28)</td><td>26 (24&#8211;28)</td><td>.081</td></tr><tr><td> Oxygen saturation, %</td><td>99 (99&#8211;100)</td><td>99 (98&#8211;100)</td><td>100 (99&#8211;100)</td><td>.504</td></tr><tr><td> Palpable liver, No. (%)</td><td>14 (31.8)</td><td>20 (28.2)</td><td>8 (25.8)</td><td>.842</td></tr><tr><td> Palpable spleen, No. (%)</td><td>9 (20.5)</td><td>12 (16.9)</td><td>2 (6.5)</td><td>.244</td></tr><tr><td> Rash, No. (%)</td><td>1 (2.3)</td><td>0 (0)</td><td>1 (3.2)</td><td>.360</td></tr><tr><td>Parasite count/&#956;L</td><td>1722 (386&#8211;4830)</td><td>5967 (1829&#8211;13901)</td><td>7392 (1462&#8211;36546)</td><td>&lt;.001</td></tr><tr><td>Parasite count/&#956;L, range</td><td>36&#8211;74365</td><td>109&#8211;140500</td><td>61&#8211;635415</td><td></td></tr><tr><td>Schizont proportion, mean % (SD)</td><td>3 (7.5)</td><td>1 (4.0)</td><td>0 (0)</td><td>.013</td></tr><tr><td>Schizont proportion &gt;10%, No. (%)</td><td>3 (6.8)</td><td>1 (1.5)</td><td>0 (0)</td><td>.138</td></tr><tr><td>Parasite count &gt;20000/&#956;L, No. (%)</td><td>4 (9)</td><td>8 (11)</td><td>12 (39)</td><td>.001</td></tr><tr><td>Gametocytes present, no./No. (%)</td><td>4/35 (11)</td><td>21/66 (32)</td><td>1/11 (9)</td><td>.035</td></tr><tr><td>Hemoglobin, g/dL</td><td>10.6 (9.7&#8211;11.3)</td><td>10.1 (9.3&#8211;11.2)</td><td>10.3 (9.2&#8211;11.6)</td><td>.726</td></tr><tr><td>Anemia<sup>a</sup> (baseline), No. (%)</td><td>36 (82)</td><td>56 (79)</td><td>21 (68)</td><td>.328</td></tr><tr><td>G6PD deficiency present, no./No. (%)</td><td>1/38 (2.6)</td><td>3/69 (4.3)</td><td>1/18 (5.6)</td><td>.852</td></tr><tr><td>White blood cell count, &#215; 10<sup>3</sup>/&#956;L</td><td>6.1 (5.1&#8211;7.5)</td><td>7.1 (5.1&#8211;8.6)</td><td>9.2 (6.4&#8211;12.7)</td><td>.002</td></tr><tr><td>Neutrophil count, &#215; 10<sup>3</sup>/&#956;L</td><td>2.7 (2.0&#8211;3.5)</td><td>3.3 (2.5&#8211;4.8)</td><td>3.8 (2.5&#8211;6.8)</td><td>.015</td></tr><tr><td>Lymphocyte count, &#215; 10<sup>3</sup>/&#956;L</td><td>2.0 (1.4&#8211;2.7)</td><td>2.2 (1.6&#8211;2.9)</td><td>2.8 (1.7&#8211;5.0)</td><td>.025</td></tr><tr><td>Monocyte count, &#215; 10<sup>3</sup>/&#956;L</td><td>1.1 (0.8&#8211;1.4)</td><td>0.9 (0.6&#8211;1.3)</td><td>1.2 (0.7&#8211;1.4)</td><td>.241</td></tr><tr><td>Platelet count, &#215; 10<sup>3</sup>/&#956;L</td><td>106 (80&#8211;163)</td><td>120 (93&#8211;179)</td><td>159 (83&#8211;282)</td><td>.078</td></tr><tr><td>Platelet nadir, &#215; 10<sup>3</sup>/&#956;L</td><td>78 (60&#8211;134)</td><td>104 (70&#8211;154)</td><td>129 (63&#8211;275)</td><td>&lt;.001</td></tr><tr><td>Platelet nadir, d</td><td>1 (0&#8211;1)</td><td>1 (0&#8211;1)</td><td>1 (0&#8211;1)</td><td>1.000</td></tr><tr><td>Thrombocytopenia (platelets &lt;150 &#215; 10<sup>3</sup>/&#956;L), No. (%)</td><td>30 (68)</td><td>46 (65)</td><td>13 (42)</td><td>.047</td></tr><tr><td>Creatinine, &#956;mol/L</td><td>48 (36&#8211;57)</td><td>48 (34&#8211;58)</td><td>40 (31&#8211;53)</td><td>.267</td></tr><tr><td>Urea, mmol/L</td><td>3.8 (2.8&#8211;4.5)</td><td>3.5 (3.0&#8211;4.6)</td><td>3.2 (2.3&#8211;4.5)</td><td>.167</td></tr><tr><td>Sodium, mmol/L</td><td>137 (135&#8211;139)</td><td>137 (136&#8211;139)</td><td>136 (133&#8211;139)</td><td>.640</td></tr><tr><td>Bilirubin, &#956;mol/L</td><td>11.5 (8.3&#8211;15.8)</td><td>9.8 (6.0&#8211;14.6)</td><td>11.0 (6.8&#8211;19.7)</td><td>.474</td></tr><tr><td>Glucose, mmol/L</td><td>5.8 (5.1&#8211;6.8)</td><td>5.7 (5.0&#8211;6.4)</td><td>6.2 (5.6&#8211;6.6)</td><td>.802</td></tr><tr><td>Albumin, g/dL</td><td>35 (31&#8211;37)</td><td>34 (28&#8211;36)</td><td>32 (29&#8211;37)</td><td>.644</td></tr><tr><td>AST, IU/L</td><td>25 (23&#8211;34)</td><td>24 (15&#8211;28)</td><td>37 (24&#8211;42)</td><td>.268</td></tr><tr><td>ALT, IU/L</td><td>16 (11&#8211;32)</td><td>17 (11&#8211;28)</td><td>24 (14&#8211;32)</td><td>.270</td></tr><tr><td>Bicarbonate, mmol/L</td><td>23 (21&#8211;25)</td><td>22 (20&#8211;26)</td><td>25 (21&#8211;26)</td><td>.418</td></tr><tr><td>Acute kidney injury, No. (%)</td><td>11 (26)</td><td>7 (10)</td><td>10 (32)</td><td>.016</td></tr><tr><td>Blood culture positive<sup>b</sup>, No. (%)</td><td>0/33 (0)</td><td>0/28 (0)</td><td>0/15 (0)</td><td>1.000</td></tr></table>
<table><tr><td>Patient Characteristic</td><td>Plasmodium knowlesi</td><td>Plasmodium vivax</td><td>Plasmodium falciparum</td><td>P Value</td></tr><tr><td>Children (age ≀12 y), No. (% total)</td><td>44 (9.1)</td><td>71 (41.3)</td><td>31 (32.3)</td><td><.001</td></tr><tr><td colspan="5">Age, y</td></tr><tr><td>Median (IQR)</td><td>8 (5–10)</td><td>9 (5–10)</td><td>7 (3–10)</td><td>.095</td></tr><tr><td>Range</td><td>0.1–12</td><td>0.67–12</td><td>1–12</td><td></td></tr><tr><td>Male sex, No. (%)</td><td>25 (56.8)</td><td>34 (47.9)</td><td>21 (67.7)</td><td>.170</td></tr><tr><td>Previous malaria (self-reported), No. (%)</td><td>4 (9.1)</td><td>11 (15.5)</td><td>3 (9.7)</td><td>.526</td></tr><tr><td>History of chronic disease, No. (%)</td><td>2 (4.5)</td><td>0</td><td>0</td><td>.095</td></tr><tr><td>Days of fever</td><td>5 (3–7)</td><td>5 (3–7)</td><td>4 (3–5)</td><td>.751</td></tr><tr><td colspan="5">Symptoms on enrollment, No. (%)</td></tr><tr><td>Rigors</td><td>29 (65.9)</td><td>55 (77.5)</td><td>14 (45.2)</td><td>.006</td></tr><tr><td>Headache</td><td>34 (77.3)</td><td>55 (77.5)</td><td>21 (67.7)</td><td>.542</td></tr><tr><td>Vomiting</td><td>14 (31.8)</td><td>37 (52.1)</td><td>11 (35.5)</td><td>.068</td></tr><tr><td>Abdominal pain</td><td>19 (43.2)</td><td>9 (12.7)</td><td>9 (29.0)</td><td>.001</td></tr><tr><td>Diarrhea</td><td>4 (9.1)</td><td>2 (2.8)</td><td>4 (12.9)</td><td>.140</td></tr><tr><td>Cough</td><td>15 (34.1)</td><td>25 (35.2)</td><td>12 (38.7)</td><td>.914</td></tr></table>
<table><tr><td>Shortness of breath</td><td>3 (6.8)</td><td>4 (5.6)</td><td>4 (12.9)</td><td>.431</td></tr><tr><td>Myalgia</td><td>11 (25.0)</td><td>15 (21.1)</td><td>7 (22.6)</td><td>.890</td></tr><tr><td>Arthralgia</td><td>12 (27.3)</td><td>15 (21.1)</td><td>7 (22.6)</td><td>.746</td></tr><tr><td colspan="5">Examination findings on enrollment</td></tr><tr><td>Temperature, Β°C</td><td>37.1 (36.8–37.9)</td><td>37.4 (36.8–37.8)</td><td>37.1 (36.8–38)</td><td>.647</td></tr><tr><td>Fever (β‰₯37.5Β°C), No. (%)</td><td>17 (38.6)</td><td>33 (46.5)</td><td>12 (38.7)</td><td>.634</td></tr><tr><td>Systolic blood pressure, mm Hg</td><td>101 (94–109)</td><td>102 (96–110)</td><td>106 (98–112)</td><td>.356</td></tr><tr><td>Heart rate, beats/min</td><td>104 (93–119)</td><td>105 (94–118)</td><td>117 (96–134)</td><td>.688</td></tr><tr><td>Respiratory rate, breaths/min</td><td>24 (22–27)</td><td>24 (22–28)</td><td>26 (24–28)</td><td>.081</td></tr><tr><td>Oxygen saturation, %</td><td>99 (99–100)</td><td>99 (98–100)</td><td>100 (99–100)</td><td>.504</td></tr><tr><td>Palpable liver, No. (%)</td><td>14 (31.8)</td><td>20 (28.2)</td><td>8 (25.8)</td><td>.842</td></tr><tr><td>Palpable spleen, No. (%)</td><td>9 (20.5)</td><td>12 (16.9)</td><td>2 (6.5)</td><td>.244</td></tr><tr><td>Rash, No. (%)</td><td>1 (2.3)</td><td>0 (0)</td><td>1 (3.2)</td><td>.360</td></tr><tr><td>Parasite count/ΞΌL</td><td>1722 (386–4830)</td><td>5967 (1829–13901)</td><td>7392 (1462–36546)</td><td><.001</td></tr><tr><td>Parasite count/ΞΌL, range</td><td>36–74365</td><td>109–140500</td><td>61–635415</td><td></td></tr><tr><td>Schizont proportion, mean % (SD)</td><td>3 (7.5)</td><td>1 (4.0)</td><td>0 (0)</td><td>.013</td></tr><tr><td>Schizont proportion >10%, No. (%)</td><td>3 (6.8)</td><td>1 (1.5)</td><td>0 (0)</td><td>.138</td></tr><tr><td>Parasite count >20000/ΞΌL, No. (%)</td><td>4 (9)</td><td>8 (11)</td><td>12 (39)</td><td>.001</td></tr><tr><td>Gametocytes present, no./No. (%)</td><td>4/35 (11)</td><td>21/66 (32)</td><td>1/11 (9)</td><td>.035</td></tr><tr><td>Hemoglobin, g/dL</td><td>10.6 (9.7–11.3)</td><td>10.1 (9.3–11.2)</td><td>10.3 (9.2–11.6)</td><td>.726</td></tr><tr><td>Anemiaa (baseline), No. (%)</td><td>36 (82)</td><td>56 (79)</td><td>21 (68)</td><td>.328</td></tr><tr><td>G6PD deficiency present, no./No. (%)</td><td>1/38 (2.6)</td><td>3/69 (4.3)</td><td>1/18 (5.6)</td><td>.852</td></tr><tr><td>White blood cell count, Γ— 103/ΞΌL</td><td>6.1 (5.1–7.5)</td><td>7.1 (5.1–8.6)</td><td>9.2 (6.4–12.7)</td><td>.002</td></tr><tr><td>Neutrophil count, Γ— 103/ΞΌL</td><td>2.7 (2.0–3.5)</td><td>3.3 (2.5–4.8)</td><td>3.8 (2.5–6.8)</td><td>.015</td></tr><tr><td>Lymphocyte count, Γ— 103/ΞΌL</td><td>2.0 (1.4–2.7)</td><td>2.2 (1.6–2.9)</td><td>2.8 (1.7–5.0)</td><td>.025</td></tr><tr><td>Monocyte count, Γ— 103/ΞΌL</td><td>1.1 (0.8–1.4)</td><td>0.9 (0.6–1.3)</td><td>1.2 (0.7–1.4)</td><td>.241</td></tr><tr><td>Platelet count, Γ— 103/ΞΌL</td><td>106 (80–163)</td><td>120 (93–179)</td><td>159 (83–282)</td><td>.078</td></tr><tr><td>Platelet nadir, Γ— 103/ΞΌL</td><td>78 (60–134)</td><td>104 (70–154)</td><td>129 (63–275)</td><td><.001</td></tr><tr><td>Platelet nadir, d</td><td>1 (0–1)</td><td>1 (0–1)</td><td>1 (0–1)</td><td>1.000</td></tr><tr><td>Thrombocytopenia (platelets <150 Γ— 103/ΞΌL), No. (%)</td><td>30 (68)</td><td>46 (65)</td><td>13 (42)</td><td>.047</td></tr><tr><td>Creatinine, ΞΌmol/L</td><td>48 (36–57)</td><td>48 (34–58)</td><td>40 (31–53)</td><td>.267</td></tr><tr><td>Urea, mmol/L</td><td>3.8 (2.8–4.5)</td><td>3.5 (3.0–4.6)</td><td>3.2 (2.3–4.5)</td><td>.167</td></tr><tr><td>Sodium, mmol/L</td><td>137 (135–139)</td><td>137 (136–139)</td><td>136 (133–139)</td><td>.640</td></tr><tr><td>Bilirubin, ΞΌmol/L</td><td>11.5 (8.3–15.8)</td><td>9.8 (6.0–14.6)</td><td>11.0 (6.8–19.7)</td><td>.474</td></tr><tr><td>Glucose, mmol/L</td><td>5.8 (5.1–6.8)</td><td>5.7 (5.0–6.4)</td><td>6.2 (5.6–6.6)</td><td>.802</td></tr><tr><td>Albumin, g/dL</td><td>35 (31–37)</td><td>34 (28–36)</td><td>32 (29–37)</td><td>.644</td></tr><tr><td>AST, IU/L</td><td>25 (23–34)</td><td>24 (15–28)</td><td>37 (24–42)</td><td>.268</td></tr><tr><td>ALT, IU/L</td><td>16 (11–32)</td><td>17 (11–28)</td><td>24 (14–32)</td><td>.270</td></tr><tr><td>Bicarbonate, mmol/L</td><td>23 (21–25)</td><td>22 (20–26)</td><td>25 (21–26)</td><td>.418</td></tr><tr><td>Acute kidney injury, No. (%)</td><td>11 (26)</td><td>7 (10)</td><td>10 (32)</td><td>.016</td></tr><tr><td>Blood culture positiveb, No. (%)</td><td>0/33 (0)</td><td>0/28 (0)</td><td>0/15 (0)</td><td>1.000</td></tr></table>
1ec75d8e9e31853ca030994bb15819c3e366990b4a541a01a35d6d817a8fd2ae.png
complex
<table><tr><td>Correlates<sup>a</sup></td><td>Unadjusted OR</td><td>ORa</td><td>95% CI of the ORa</td><td><i>p</i>-Value</td></tr><tr><td colspan="5">Vegetarian/low calories diet versus mixed diet<sup>b</sup></td></tr><tr><td>Older age</td><td>1.04</td><td>1.04</td><td>0.98&#8211;1.11</td><td>0.168</td></tr><tr><td>Income level</td><td></td><td></td><td></td><td>0.012</td></tr><tr><td> Quartile 1 (reference)</td><td>1.00</td><td></td><td></td><td></td></tr><tr><td> Quartile 2</td><td>0.95</td><td>0.93</td><td>0.69&#8211;1.26</td><td>0.630</td></tr><tr><td> Quartile 3</td><td>1.01</td><td>0.94</td><td>0.68&#8211;1.31</td><td>0.721</td></tr><tr><td> Quartile 4</td><td>1.41</td><td>1.45</td><td>1.06&#8211;1.99</td><td>0.021</td></tr><tr><td>Body mass index</td><td></td><td></td><td></td><td>0.035</td></tr><tr><td> Underweight (reference)</td><td>1.00</td><td></td><td></td><td></td></tr><tr><td> Normal weight</td><td>1.25</td><td>1.41</td><td>0.96&#8211;2.07</td><td>0.076</td></tr><tr><td> Overweight</td><td>1.30</td><td>1.45</td><td>0.90&#8211;2.32</td><td>0.136</td></tr><tr><td> Obese</td><td>1.44</td><td>2.80</td><td>1.40&#8211;5.61</td><td>0.004</td></tr><tr><td>Private versus public university</td><td>1.18</td><td>1.23</td><td>0.96&#8211;1.57</td><td>0.099</td></tr><tr><td>Higher physical activity level</td><td></td><td></td><td></td><td>0.651</td></tr><tr><td> No activity (reference)</td><td>1.00</td><td></td><td></td><td></td></tr><tr><td> Quartile 1</td><td>1.13</td><td>1.21</td><td>0.88&#8211;1.64</td><td>0.237</td></tr><tr><td> Quartile 2</td><td>1.11</td><td>1.19</td><td>0.86&#8211;1.64</td><td>0.304</td></tr><tr><td> Quartile 3</td><td>1.12</td><td>1.05</td><td>0.76&#8211;1.47</td><td>0.759</td></tr><tr><td> Quartile 4</td><td>1.03</td><td>1.23</td><td>0.86&#8211;1.75</td><td>0.260</td></tr><tr><td>Female versus male gender</td><td>1.36</td><td>1.62</td><td>1.24&#8211;2.12</td><td>&lt;0.001</td></tr><tr><td colspan="5">Westernized diet versus mixed diet<sup>c</sup></td></tr><tr><td>Older Age</td><td>0.78</td><td>0.98</td><td>0.93&#8211;1.04</td><td>0.534</td></tr><tr><td>Income level</td><td></td><td></td><td></td><td>0.468</td></tr><tr><td> Quartile 1 (reference)</td><td>1.0</td><td></td><td></td><td></td></tr><tr><td> Quartile 2</td><td>0.95</td><td>0.90</td><td>0.68&#8211;1.17</td><td>0.422</td></tr><tr><td> Quartile 3</td><td>1.21</td><td>1.06</td><td>0.80&#8211;1.41</td><td>0.693</td></tr><tr><td> Quartile 4</td><td>1.23</td><td>1.12</td><td>0.84&#8211;1.49</td><td>0.458</td></tr><tr><td>Body mass index</td><td></td><td></td><td></td><td>0.616</td></tr><tr><td> Underweight (reference)</td><td>1.00</td><td></td><td></td><td></td></tr><tr><td> Normal weight</td><td>1.13</td><td>1.08</td><td>0.78&#8211;1.51</td><td>0.643</td></tr><tr><td> Overweight</td><td>1.25</td><td>0.96</td><td>0.63&#8211;1.45</td><td>0.835</td></tr><tr><td> Obese</td><td>1.35</td><td>1.36</td><td>0.73&#8211;2.53</td><td>0.335</td></tr><tr><td>Private versus public university</td><td>1.22</td><td>1.15</td><td>0.92&#8211;1.43</td><td>0.214</td></tr><tr><td>Higher physical activity level</td><td></td><td></td><td></td><td>0.038</td></tr><tr><td> No activity (reference)</td><td>1.00</td><td></td><td></td><td></td></tr><tr><td> Quartile 1 Low physical activity</td><td>0.73</td><td>0.75</td><td>0.56&#8211;1.00</td><td>0.046</td></tr><tr><td> Quartile 2 moderate Physical activity</td><td>0.74</td><td>0.63</td><td>0.47&#8211;0.86</td><td>0.003</td></tr><tr><td> Quartile 3 high physical activity</td><td>0.96</td><td>0.82</td><td>0.61&#8211;1.09</td><td>0.171</td></tr><tr><td> Quartile 4 very high physical activity</td><td>1.19</td><td>0.86</td><td>0.63&#8211;1.18</td><td>0.359</td></tr><tr><td>Female versus male gender</td><td>0.69</td><td>0.64</td><td>0.50&#8211;0.80</td><td>&lt;0.001</td></tr></table>
<table><tr><td>Correlatesa</td><td>Unadjusted OR</td><td>ORa</td><td>95% CI of the ORa</td><td>p-Value</td></tr><tr><td colspan="5">Vegetarian/low calories diet versus mixed dietb</td></tr><tr><td>Older age</td><td>1.04</td><td>1.04</td><td>0.98–1.11</td><td>0.168</td></tr><tr><td>Income level</td><td></td><td></td><td></td><td>0.012</td></tr><tr><td>Quartile 1 (reference)</td><td>1.00</td><td></td><td></td><td></td></tr><tr><td>Quartile 2</td><td>0.95</td><td>0.93</td><td>0.69–1.26</td><td>0.630</td></tr><tr><td>Quartile 3</td><td>1.01</td><td>0.94</td><td>0.68–1.31</td><td>0.721</td></tr><tr><td>Quartile 4</td><td>1.41</td><td>1.45</td><td>1.06–1.99</td><td>0.021</td></tr><tr><td>Body mass index</td><td></td><td></td><td></td><td>0.035</td></tr><tr><td>Underweight (reference)</td><td>1.00</td><td></td><td></td><td></td></tr><tr><td>Normal weight</td><td>1.25</td><td>1.41</td><td>0.96–2.07</td><td>0.076</td></tr><tr><td>Overweight</td><td>1.30</td><td>1.45</td><td>0.90–2.32</td><td>0.136</td></tr><tr><td>Obese</td><td>1.44</td><td>2.80</td><td>1.40–5.61</td><td>0.004</td></tr><tr><td>Private versus public university</td><td>1.18</td><td>1.23</td><td>0.96–1.57</td><td>0.099</td></tr><tr><td>Higher physical activity level</td><td></td><td></td><td></td><td>0.651</td></tr><tr><td>No activity (reference)</td><td>1.00</td><td></td><td></td><td></td></tr><tr><td>Quartile 1</td><td>1.13</td><td>1.21</td><td>0.88–1.64</td><td>0.237</td></tr><tr><td>Quartile 2</td><td>1.11</td><td>1.19</td><td>0.86–1.64</td><td>0.304</td></tr><tr><td>Quartile 3</td><td>1.12</td><td>1.05</td><td>0.76–1.47</td><td>0.759</td></tr><tr><td>Quartile 4</td><td>1.03</td><td>1.23</td><td>0.86–1.75</td><td>0.260</td></tr><tr><td>Female versus male gender</td><td>1.36</td><td>1.62</td><td>1.24–2.12</td><td><0.001</td></tr><tr><td colspan="5">Westernized diet versus mixed dietc</td></tr><tr><td>Older Age</td><td>0.78</td><td>0.98</td><td>0.93–1.04</td><td>0.534</td></tr><tr><td>Income level</td><td></td><td></td><td></td><td>0.468</td></tr><tr><td>Quartile 1 (reference)</td><td>1.0</td><td></td><td></td><td></td></tr><tr><td>Quartile 2</td><td>0.95</td><td>0.90</td><td>0.68–1.17</td><td>0.422</td></tr><tr><td>Quartile 3</td><td>1.21</td><td>1.06</td><td>0.80–1.41</td><td>0.693</td></tr><tr><td>Quartile 4</td><td>1.23</td><td>1.12</td><td>0.84–1.49</td><td>0.458</td></tr><tr><td>Body mass index</td><td></td><td></td><td></td><td>0.616</td></tr><tr><td>Underweight (reference)</td><td>1.00</td><td></td><td></td><td></td></tr><tr><td>Normal weight</td><td>1.13</td><td>1.08</td><td>0.78–1.51</td><td>0.643</td></tr><tr><td>Overweight</td><td>1.25</td><td>0.96</td><td>0.63–1.45</td><td>0.835</td></tr><tr><td>Obese</td><td>1.35</td><td>1.36</td><td>0.73–2.53</td><td>0.335</td></tr><tr><td>Private versus public university</td><td>1.22</td><td>1.15</td><td>0.92–1.43</td><td>0.214</td></tr><tr><td>Higher physical activity level</td><td></td><td></td><td></td><td>0.038</td></tr><tr><td>No activity (reference)</td><td>1.00</td><td></td><td></td><td></td></tr><tr><td>Quartile 1 Low physical activity</td><td>0.73</td><td>0.75</td><td>0.56–1.00</td><td>0.046</td></tr><tr><td>Quartile 2 moderate Physical activity</td><td>0.74</td><td>0.63</td><td>0.47–0.86</td><td>0.003</td></tr></table>
<table><tr><td>Quartile 3 high physical activity</td><td>0.96</td><td>0.82</td><td>0.61–1.09</td><td>0.171</td></tr><tr><td>Quartile 4 very high physical activity</td><td>1.19</td><td>0.86</td><td>0.63–1.18</td><td>0.359</td></tr><tr><td>Female versus male gender</td><td>0.69</td><td>0.64</td><td>0.50–0.80</td><td><0.001</td></tr></table>
ec3e707ee77f1a7bc302a404a010f913945cb06a01a93d1a32288907164b200c.png
simple
<table><tr><td>Species</td><td>Family</td><td>Origin</td><td>Reference</td></tr><tr><td><i>Agrotis hephaestaea</i> (Meyrick)</td><td>Noctuidae</td><td>Endemic</td><td>[49]</td></tr><tr><td><i>Ethmia nigroapicella</i> (Saalmuller)</td><td>Oecophoridae</td><td>Adventive</td><td>[48]</td></tr><tr><td><i>Eudonia</i> sp.</td><td>Crambidae</td><td>Endemic</td><td>[49]</td></tr><tr><td><i>Eupithecia monticolens</i> Butler</td><td>Geometridae</td><td>Endemic</td><td>[49]</td></tr><tr><td><i>Fletcherana leucoxyla</i> Meyrick</td><td>Geometridae</td><td>Endemic</td><td>[49]</td></tr><tr><td><i>Haliophyle euclidias</i> Meyrick</td><td>Noctuidae</td><td>Endemic</td><td>[49]</td></tr><tr><td><i>Scotorythra arboricolans</i> Butler</td><td>Geometridae</td><td>Endemic</td><td>[49]</td></tr><tr><td><i>Scotorytorythra caryopis</i> Meyrick</td><td>Geometridae</td><td>Endemic</td><td>[48]</td></tr><tr><td><i>Scotorythra hecataea</i> Meyrick</td><td>Geometridae</td><td>Endemic</td><td>[49]</td></tr><tr><td><i>Scotorythra pauludicola</i> (Butler)</td><td>Geometridae</td><td>Endemic</td><td>[48]</td></tr><tr><td><i>Scotorythra rara</i> Butler</td><td>Geometridae</td><td>Endemic</td><td>[49]</td></tr><tr><td><i>Scotorythra trapezias</i> Meyrick</td><td>Geometridae</td><td>Endemic</td><td>[48]</td></tr><tr><td><i>Scotorythra</i> spp.</td><td>Geometridae</td><td>Endemic</td><td>[49]</td></tr><tr><td><i>Spodalea recurvalis</i> (Fabricius)</td><td>Crambidae</td><td>Adventive</td><td>[48]</td></tr><tr><td><i>Pseudaletia unipuncta</i> (Haworth)</td><td>Noctuidae</td><td>Adventive</td><td>[48]</td></tr><tr><td><i>Spodoptera exempta</i> (Walker)</td><td>Noctuidae</td><td>Adventive *</td><td>[48]</td></tr><tr><td><i>Spodoptera mauritia</i> (Boisduval)</td><td>Noctuidae</td><td>Adventive</td><td>[48]</td></tr><tr><td><i>Spheretista pleonectes Walsingham</i></td><td>Tortricidae</td><td>Endemic</td><td>[49]</td></tr><tr><td><i>Udea stellata</i> (Butler)</td><td>Crambidae</td><td>Endemic</td><td>[33]</td></tr></table>
<table><tr><td>Species</td><td>Family</td><td>Origin</td><td>Reference</td></tr><tr><td>Agrotis hephaestaea (Meyrick)</td><td>Noctuidae</td><td>Endemic</td><td>[49]</td></tr><tr><td>Ethmia nigroapicella (Saalmuller)</td><td>Oecophoridae</td><td>Adventive</td><td>[48]</td></tr><tr><td>Eudonia sp.</td><td>Crambidae</td><td>Endemic</td><td>[49]</td></tr><tr><td>Eupithecia monticolens Butler</td><td>Geometridae</td><td>Endemic</td><td>[49]</td></tr><tr><td>Fletcherana leucoxyla Meyrick</td><td>Geometridae</td><td>Endemic</td><td>[49]</td></tr><tr><td>Haliophyle euclidias Meyrick</td><td>Noctuidae</td><td>Endemic</td><td>[49]</td></tr><tr><td>Scotorythra arboricolans Butler</td><td>Geometridae</td><td>Endemic</td><td>[49]</td></tr><tr><td>Scotorytorythra caryopis Meyrick</td><td>Geometridae</td><td>Endemic</td><td>[48]</td></tr><tr><td>Scotorythra hecataea Meyrick</td><td>Geometridae</td><td>Endemic</td><td>[49]</td></tr><tr><td>Scotorythra pauludicola (Butler)</td><td>Geometridae</td><td>Endemic</td><td>[48]</td></tr></table>
<table><tr><td>Species</td><td>Family</td><td>Origin</td><td>Reference</td></tr><tr><td>Scotorythra rara Butler</td><td>Geometridae</td><td>Endemic</td><td>[49]</td></tr><tr><td>Scotorythra trapezias Meyrick</td><td>Geometridae</td><td>Endemic</td><td>[48]</td></tr><tr><td>Scotorythra spp.</td><td>Geometridae</td><td>Endemic</td><td>[49]</td></tr><tr><td>Spodalea recurvalis (Fabricius)</td><td>Crambidae</td><td>Adventive</td><td>[48]</td></tr><tr><td>Pseudaletia unipuncta (Haworth)</td><td>Noctuidae</td><td>Adventive</td><td>[48]</td></tr><tr><td>Spodoptera exempta (Walker)</td><td>Noctuidae</td><td>Adventive *</td><td>[48]</td></tr><tr><td>Spodoptera mauritia (Boisduval)</td><td>Noctuidae</td><td>Adventive</td><td>[48]</td></tr><tr><td>Spheretista pleonectes Walsingham</td><td>Tortricidae</td><td>Endemic</td><td>[49]</td></tr><tr><td>Udea stellata (Butler)</td><td>Crambidae</td><td>Endemic</td><td>[33]</td></tr></table>
4a452a7ca202b86a1900b1a2f5d0e810cf246a5460d58e1064f4aec138efa6b6.png
complex
<table><tr><td>No.</td><td> </td><td>Mean</td><td>SD</td></tr><tr><td colspan="2"><i>Management: General</i></td><td> </td><td> </td></tr><tr><td>11</td><td>Different approaches are used on this ward to manage patient aggression and violence.</td><td>1.7</td><td>0.8</td></tr><tr><td>24</td><td>Patient aggression could be handled more effectively on this ward.</td><td>2.1</td><td>0.8</td></tr><tr><td colspan="4"><i>Management: Use of medication</i></td></tr><tr><td>16</td><td>Medication is a valuable approach for treating aggressive and violent behaviour.</td><td>2.3</td><td>0.9</td></tr><tr><td>25</td><td>Prescribed medication can in some instances lead to patient aggression and violence.</td><td>2.2</td><td>0.6</td></tr><tr><td>28</td><td>Prescribed medication should be used more frequently to help patients who are aggressive and violent.</td><td>2.4</td><td>0.9</td></tr><tr><td colspan="4"><i>Management: Use of seclusion</i></td></tr><tr><td>13</td><td>When a patient is violent, seclusion is one of the most effective approaches to use.</td><td>2.7</td><td>0.9</td></tr><tr><td>15</td><td>The practice of secluding violent patients should be discontinued.</td><td>3.0</td><td>0.8</td></tr><tr><td>27</td><td>Seclusion is sometimes used more than necessary.</td><td>2.5</td><td>0.9</td></tr><tr><td colspan="4"><i>Management: Restraint</i></td></tr><tr><td>14</td><td>Patients who are violent are often restrained for their own safety.</td><td>2.5</td><td>0.9</td></tr><tr><td>21</td><td>Physical restraint is sometimes used more than necessary.</td><td>2.4</td><td>0.9</td></tr><tr><td colspan="4"><i>Management: Non-physical methods</i></td></tr><tr><td>18</td><td>Negotiation could be used more effectively when managing aggression and violence.</td><td>1.9</td><td>0.7</td></tr><tr><td>20</td><td>Expressions of aggression do not always require staff intervention.</td><td>2.5</td><td>0.8</td></tr><tr><td>22</td><td>Alternatives to the use of containment and sedation to manage patient violence could be used more frequently.</td><td>2.1</td><td>0.7</td></tr><tr><td>29</td><td>The use of de-escalation is successful in preventing violence.</td><td>1.7</td><td>0.6</td></tr></table>
<table><tr><td>No.</td><td></td><td>Mean</td><td>SD</td></tr><tr><td colspan="2">Management: General</td><td></td><td></td></tr><tr><td>11</td><td>Different approaches are used on this ward to manage patient aggression and violence.</td><td>1.7</td><td>0.8</td></tr><tr><td>24</td><td>Patient aggression could be handled more effectively on this ward.</td><td>2.1</td><td>0.8</td></tr><tr><td colspan="4">Management: Use of medication</td></tr><tr><td>16</td><td>Medication is a valuable approach for treating aggressive and violent behaviour.</td><td>2.3</td><td>0.9</td></tr><tr><td>25</td><td>Prescribed medication can in some instances lead to patient aggression and violence.</td><td>2.2</td><td>0.6</td></tr><tr><td>28</td><td>Prescribed medication should be used more frequently to help patients who are aggressive and violent.</td><td>2.4</td><td>0.9</td></tr><tr><td colspan="4">Management: Use of seclusion</td></tr><tr><td>13</td><td>When a patient is violent, seclusion is one of the most effective approaches to use.</td><td>2.7</td><td>0.9</td></tr><tr><td>15</td><td>The practice of secluding violent patients should be discontinued.</td><td>3.0</td><td>0.8</td></tr><tr><td>27</td><td>Seclusion is sometimes used more than necessary.</td><td>2.5</td><td>0.9</td></tr><tr><td colspan="4">Management: Restraint</td></tr><tr><td>14</td><td>Patients who are violent are often restrained for their own safety.</td><td>2.5</td><td>0.9</td></tr><tr><td>21</td><td>Physical restraint is sometimes used more than necessary.</td><td>2.4</td><td>0.9</td></tr><tr><td colspan="4">Management: Non-physical methods</td></tr></table>
<table><tr><td>18</td><td>Negotiation could be used more effectively when managing aggression and violence.</td><td>1.9</td><td>0.7</td></tr><tr><td>20</td><td>Expressions of aggression do not always require staff intervention.</td><td>2.5</td><td>0.8</td></tr><tr><td>22</td><td>Alternatives to the use of containment and sedation to manage patient violence could be used more frequently.</td><td>2.1</td><td>0.7</td></tr><tr><td>29</td><td>The use of de-escalation is successful in preventing violence.</td><td>1.7</td><td>0.6</td></tr></table>
43e7a6c353e122c5430a393b9ccb14a76ecb0136fbdca0edfbc014ea9fd98b7f.png
simple
<table><tr><td>Step</td><td>Push node</td><td>flow</td><td>Received node</td></tr><tr><td>1</td><td>S</td><td>&#8734;</td><td>G1</td></tr><tr><td>2</td><td>G1</td><td>1.83</td><td>G6</td></tr><tr><td>3</td><td>G1</td><td>0.69</td><td>G3</td></tr><tr><td>4</td><td>G3</td><td>0.69</td><td>G7</td></tr><tr><td>5</td><td>G6</td><td>1.83</td><td>T</td></tr><tr><td>6</td><td>G7</td><td>0.69</td><td>T</td></tr></table>
<table><tr><td>Step</td></tr><tr><td>1</td></tr><tr><td>2</td></tr><tr><td>3</td></tr><tr><td>4</td></tr><tr><td>5</td></tr><tr><td>6</td></tr></table>
<table><tr><td>Push node</td><td>flow</td><td>Received node</td></tr><tr><td>S</td><td>∞</td><td>G1</td></tr><tr><td>G1</td><td>1.83</td><td>G6</td></tr><tr><td>G1</td><td>0.69</td><td>G3</td></tr><tr><td>G3</td><td>0.69</td><td>G7</td></tr><tr><td>G6</td><td>1.83</td><td>T</td></tr><tr><td>G7</td><td>0.69</td><td>T</td></tr></table>
1dc189b64826957e90c78224b82a52d2280cbdbfbe2391f29733cc1dac783821.png
simple
<table><tr><td>VITBRK2</td><td>Growth characteristics</td></tr><tr><td>Growth under anaerobic conditions</td><td>Negative</td></tr><tr><td>Gram stain</td><td>Positive</td></tr><tr><td>Shape and growth</td><td>Long filamentous</td></tr><tr><td>Motility</td><td>Non-motile</td></tr><tr><td>Temperature range for growth</td><td>25-37&#176;C</td></tr><tr><td>Optimum temperature</td><td>28&#176;C</td></tr><tr><td>Range of pH for growth</td><td>6-8</td></tr><tr><td>Growth on MacConky plates</td><td>Negative</td></tr><tr><td>Growth in the presence of NaCl</td><td>2-12 %</td></tr><tr><td>2%</td><td>Positive</td></tr><tr><td>5%</td><td>Positive</td></tr><tr><td>7%</td><td>Positive</td></tr><tr><td>9%</td><td>Positive</td></tr><tr><td>12%</td><td>Positive</td></tr><tr><td>Aerial mass colour</td><td>Whitish grey</td></tr><tr><td>Melanoid pigments</td><td>Negative</td></tr><tr><td>Reverse side pigments</td><td>Negative</td></tr><tr><td>Soluble pigments</td><td>Negative</td></tr><tr><td>Spore chain</td><td>Spiral</td></tr><tr><td>Spore surface</td><td>Smooth</td></tr><tr><td>Arabinose</td><td>Positive</td></tr><tr><td>Xylose</td><td>Positive</td></tr><tr><td>Inositol</td><td>Positive</td></tr><tr><td>Mannitol</td><td>Positive</td></tr><tr><td>Fructose</td><td>Positive</td></tr><tr><td>Rhamnose</td><td>Negative</td></tr><tr><td>Sucrose</td><td>Positive</td></tr><tr><td>Raffinose</td><td>Positive</td></tr></table>
<table><tr><td>VITBRK2</td><td>Growth characteristics</td></tr><tr><td>Growth under anaerobic conditions</td><td>Negative</td></tr><tr><td>Gram stain</td><td>Positive</td></tr><tr><td>Shape and growth</td><td>Long filamentous</td></tr><tr><td>Motility</td><td>Non-motile</td></tr><tr><td>Temperature range for growth</td><td>25-37Β°C</td></tr><tr><td>Optimum temperature</td><td>28Β°C</td></tr><tr><td>Range of pH for growth</td><td>6-8</td></tr><tr><td>Growth on MacConky plates</td><td>Negative</td></tr><tr><td>Growth in the presence of NaCl</td><td>2-12 %</td></tr><tr><td>2%</td><td>Positive</td></tr><tr><td>5%</td><td>Positive</td></tr></table>
<table><tr><td>VITBRK2</td><td>Growth characteristics</td></tr><tr><td>7%</td><td>Positive</td></tr><tr><td>9%</td><td>Positive</td></tr><tr><td>12%</td><td>Positive</td></tr><tr><td>Aerial mass colour</td><td>Whitish grey</td></tr><tr><td>Melanoid pigments</td><td>Negative</td></tr><tr><td>Reverse side pigments</td><td>Negative</td></tr><tr><td>Soluble pigments</td><td>Negative</td></tr><tr><td>Spore chain</td><td>Spiral</td></tr><tr><td>Spore surface</td><td>Smooth</td></tr><tr><td>Arabinose</td><td>Positive</td></tr><tr><td>Xylose</td><td>Positive</td></tr><tr><td>Inositol</td><td>Positive</td></tr><tr><td>Mannitol</td><td>Positive</td></tr><tr><td>Fructose</td><td>Positive</td></tr><tr><td>Rhamnose</td><td>Negative</td></tr><tr><td>Sucrose</td><td>Positive</td></tr><tr><td>Raffinose</td><td>Positive</td></tr></table>
21f187bf7bc5603e776d5436871c1a6dbe7055442047c7dc9c2a0d5a644618bf.png
simple
<table><tr><td>Spot no.</td><td>Mascot score</td><td>ID</td><td>Accession no.</td><td>Protein name</td><td>Mr/PI</td><td>SC</td><td>Description</td></tr><tr><td>H3(872)</td><td>88</td><td>FIBB</td><td>P02675</td><td>Fibrinogen beta chain</td><td>55/8.5</td><td>35</td><td>N&gt;P</td></tr><tr><td>H4(867)</td><td>62</td><td>FIBB</td><td>P02675</td><td>Fibrinogen beta chain</td><td>55/8.5</td><td>26</td><td>N&gt;P</td></tr><tr><td>H6(1026)</td><td>72</td><td>FIBB</td><td>P02675</td><td>Fibrinogen beta chain</td><td>55/8.5</td><td>29</td><td>N&gt;P</td></tr><tr><td>H7(1023)</td><td>114</td><td>TCPB</td><td>P78371</td><td>T-complex protein 1 subunit beta</td><td>57/6.0</td><td>41</td><td>N&gt;P</td></tr><tr><td>G11(1014)</td><td>57</td><td>FIBG</td><td>P02679</td><td>Fibrinogen gamma chain</td><td>51/5.3</td><td>18</td><td>N&gt;P</td></tr><tr><td>G13(1534)</td><td>63</td><td>SH319</td><td>Q5HYK7</td><td>SH3 domain-containing protein 19</td><td>86/8.5</td><td>11</td><td>N&gt;P</td></tr><tr><td>G15(812)</td><td>61</td><td>RARB</td><td>P10826</td><td>Retinoic acid receptor beta</td><td>50/8.0</td><td>11</td><td>N&gt;P</td></tr><tr><td>H16(1572)</td><td>57</td><td>GPX1</td><td>P07203</td><td>Glutathione peroxidase 1</td><td>21/6.1</td><td>23</td><td>N&gt;P</td></tr><tr><td>G1(791)</td><td>86</td><td>PDIA3</td><td>P30101</td><td>Protein disulfdte-isomerase A3</td><td>56/5.9</td><td>25</td><td>P&gt;N</td></tr><tr><td>H2(786)</td><td>94</td><td>PDIA3</td><td>P30101</td><td>Protein disulfide-isomerase A3</td><td>56/5.9</td><td>30</td><td>P&gt;N</td></tr><tr><td>G14(1317)</td><td>70</td><td>CAPZB</td><td>P47756</td><td>F-actin-capping protein subunit beta</td><td>31/5.3</td><td>26</td><td>P&gt;N</td></tr></table>
<table><tr><td>Spot no.</td><td>Mascot score</td><td>ID</td><td>Accession no.</td><td>Protein name</td><td>Mr/PI</td><td>SC</td><td>Description</td></tr><tr><td>H3(872)</td><td>88</td><td>FIBB</td><td>P02675</td><td>Fibrinogen beta chain</td><td>55/8.5</td><td>35</td><td>N>P</td></tr><tr><td>H4(867)</td><td>62</td><td>FIBB</td><td>P02675</td><td>Fibrinogen beta chain</td><td>55/8.5</td><td>26</td><td>N>P</td></tr><tr><td>H6(1026)</td><td>72</td><td>FIBB</td><td>P02675</td><td>Fibrinogen beta chain</td><td>55/8.5</td><td>29</td><td>N>P</td></tr><tr><td>H7(1023)</td><td>114</td><td>TCPB</td><td>P78371</td><td>T-complex protein 1 subunit beta</td><td>57/6.0</td><td>41</td><td>N>P</td></tr><tr><td>G11(1014)</td><td>57</td><td>FIBG</td><td>P02679</td><td>Fibrinogen gamma chain</td><td>51/5.3</td><td>18</td><td>N>P</td></tr><tr><td>G13(1534)</td><td>63</td><td>SH319</td><td>Q5HYK7</td><td>SH3 domain-containing protein 19</td><td>86/8.5</td><td>11</td><td>N>P</td></tr><tr><td>G15(812)</td><td>61</td><td>RARB</td><td>P10826</td><td>Retinoic acid receptor beta</td><td>50/8.0</td><td>11</td><td>N>P</td></tr><tr><td>H16(1572)</td><td>57</td><td>GPX1</td><td>P07203</td><td>Glutathione peroxidase 1</td><td>21/6.1</td><td>23</td><td>N>P</td></tr></table>
<table><tr><td>Spot no.</td><td>Mascot score</td><td>ID</td><td>Accession no.</td><td>Protein name</td><td>Mr/PI</td><td>SC</td><td>Description</td></tr><tr><td>G1(791)</td><td>86</td><td>PDIA3</td><td>P30101</td><td>Protein disulfdte-isomerase A3</td><td>56/5.9</td><td>25</td><td>P>N</td></tr><tr><td>H2(786)</td><td>94</td><td>PDIA3</td><td>P30101</td><td>Protein disulfide-isomerase A3</td><td>56/5.9</td><td>30</td><td>P>N</td></tr><tr><td>G14(1317)</td><td>70</td><td>CAPZB</td><td>P47756</td><td>F-actin-capping protein subunit beta</td><td>31/5.3</td><td>26</td><td>P>N</td></tr></table>
bb07493cb033bcb7361874c03c35168ed23eb145e8f56681ea9dc620d3cdbe91.png
simple
<table><tr><td></td><td>Components and processes</td></tr><tr><td>National Performance Indicators</td><td>52 National indicators spanning government priorities</td></tr><tr><td></td><td> &#8226; Governance</td></tr><tr><td></td><td> &#8226; Prevention and early intervention,</td></tr><tr><td></td><td> &#8226; Access</td></tr><tr><td></td><td> &#8226; Integration</td></tr><tr><td></td><td> &#8226; Chronic disease management</td></tr><tr><td></td><td>Compulsory reporting against a subset of national indicators and choice in reporting against local programs</td></tr><tr><td></td><td>PIs underpinned by a conceptual framework and technical details 4 levels of indicators from processes through to client outcomes</td></tr><tr><td>Accreditation</td><td>Requirement for all Divisions to become accredited by June 2008</td></tr><tr><td></td><td>Once accredited, Divisions no longer required to report on governance indicators</td></tr><tr><td>Performance Assessment</td><td>Performance against indicators is to feed into individual performance appraisal</td></tr><tr><td></td><td>At the national level, analysis and benchmarking support comparison and provide an aggregated picture of performance</td></tr><tr><td></td><td>Links to rewards (still to be determined) to reward high performance and support improvement</td></tr></table>
<table><tr><td></td><td>Components and processes</td></tr><tr><td>National Performance Indicators</td><td>52 National indicators spanning government priorities</td></tr><tr><td></td><td>β€’ Governance</td></tr><tr><td></td><td>β€’ Prevention and early intervention,</td></tr></table>
<table><tr><td></td><td>β€’ Access</td></tr><tr><td></td><td>β€’ Integration</td></tr><tr><td></td><td>β€’ Chronic disease management</td></tr><tr><td></td><td>Compulsory reporting against a subset of national indicators and choice in reporting against local programs</td></tr><tr><td></td><td>PIs underpinned by a conceptual framework and technical details 4 levels of indicators from processes through to client outcomes</td></tr><tr><td>Accreditation</td><td>Requirement for all Divisions to become accredited by June 2008</td></tr><tr><td></td><td>Once accredited, Divisions no longer required to report on governance indicators</td></tr><tr><td>Performance Assessment</td><td>Performance against indicators is to feed into individual performance appraisal</td></tr><tr><td></td><td>At the national level, analysis and benchmarking support comparison and provide an aggregated picture of performance</td></tr><tr><td></td><td>Links to rewards (still to be determined) to reward high performance and support improvement</td></tr></table>
f06799a010b329dd9a59ce25b1d52b939ccc688f6cc0bfb039b2dff049644a77.png
complex
<table><tr><td rowspan="2"></td><td colspan="3">lncRNABLACAT1</td></tr><tr><td>OR</td><td>95% CI</td><td>P value</td></tr><tr><td>PTC diagnosis</td><td>0.887</td><td>0.833&#8211;0.982</td><td>0.013*</td></tr><tr><td>Model 1</td><td></td><td></td><td></td></tr><tr><td>Lymph node metastasis</td><td></td><td></td><td></td></tr><tr><td>Model 1</td><td>0.596</td><td>0.459&#8211;0.805</td><td>&lt; 0.001**</td></tr><tr><td>Model 2</td><td>0.504</td><td>0.341&#8211;0.798</td><td>0.005*</td></tr></table>
<table><tr><td rowspan="2"></td><td>lncRNABLACAT1</td></tr><tr><td>OR</td></tr><tr><td>PTC diagnosis</td><td>0.887</td></tr><tr><td>Model 1</td><td></td></tr><tr><td>Lymph node metastasis</td><td></td></tr><tr><td>Model 1</td><td>0.596</td></tr><tr><td>Model 2</td><td>0.504</td></tr></table>
<table><tr><td colspan="2">lncRNABLACAT1</td></tr><tr><td>95% CI</td><td>P value</td></tr><tr><td>0.833–0.982</td><td>0.013*</td></tr><tr><td></td><td></td></tr><tr><td></td><td></td></tr><tr><td>0.459–0.805</td><td>< 0.001**</td></tr><tr><td>0.341–0.798</td><td>0.005*</td></tr></table>
9d683df61e7e7003bd86716d4d2a06eeabd2b9671bc379364b05c86b30d82cc3.png
simple
<table><tr><td></td><td>Naive group</td><td>Treated patients</td><td>STI patients</td></tr><tr><td>Number</td><td>10</td><td>20</td><td>15</td></tr><tr><td>Genders</td><td></td><td></td><td></td></tr><tr><td>Males</td><td>5</td><td>8</td><td>8</td></tr><tr><td>Females</td><td>5</td><td>12</td><td>6</td></tr><tr><td>Transsexuals</td><td></td><td></td><td>1</td></tr><tr><td>Mean years old</td><td>42</td><td>42</td><td>43</td></tr><tr><td>Geographic origin</td><td></td><td></td><td></td></tr><tr><td>Europeans</td><td>5</td><td>12</td><td>12</td></tr><tr><td>Other/Unknown</td><td>5</td><td>8</td><td>3</td></tr><tr><td>Mean range follow up</td><td></td><td></td><td></td></tr><tr><td>Years<sup>a</sup></td><td>4 (range 1 &#8211; 11) <sup>a</sup></td><td>7.5 (range 1 &#8211; 15)<sup>a</sup></td><td>6 (range 2 &#8211; 7) <sup>a</sup></td></tr><tr><td>CD4+ count</td><td></td><td></td><td></td></tr><tr><td>cells &#215; 10<sup>6</sup>/l</td><td>Median 391 (range 109&#8211;805)</td><td>Median 338 (range 1 &#8211; 790)</td><td>Median 717 (range 216 &#8211; 1356)</td></tr><tr><td>&lt;200 cells &#215; 10<sup>6</sup>/l (Number) <sup>b</sup></td><td>1</td><td>6</td><td>0</td></tr><tr><td>Plasma HIV-RNA</td><td></td><td></td><td></td></tr><tr><td>Log<sub>10 </sub>copies/ml</td><td>Median 4.8 (range 2.7 &#8211; 5.4)</td><td>Median 4.4 (range 1.7 &#8211; 5.9)</td><td>Median 3.2 (range 1.7 &#8211; 4.7) <sup>c</sup></td></tr><tr><td>&lt;50 copies/ml (Number)<sup>b</sup></td><td>0</td><td>5</td><td>3</td></tr><tr><td>HIV1-DNA</td><td></td><td></td><td></td></tr><tr><td>Log<sub>10 </sub>copies/10<sup>6 </sup>CD4 cells</td><td>Median 3.0 (range 2.6 &#8211; 3.7)</td><td>Median 3.3 (range 2.2 &#8211; 4.6)</td><td>Median 2.9 (range 2.1 &#8211; 4.0)</td></tr><tr><td>&lt;5 copies/PCR (Number) <sup>b</sup></td><td>6</td><td>12</td><td>5</td></tr></table>
<table><tr><td></td><td>Naive group</td><td>Treated patients</td><td>STI patients</td></tr><tr><td>Number</td><td>10</td><td>20</td><td>15</td></tr><tr><td>Genders</td><td></td><td></td><td></td></tr><tr><td>Males</td><td>5</td><td>8</td><td>8</td></tr><tr><td>Females</td><td>5</td><td>12</td><td>6</td></tr></table>
<table><tr><td></td><td>Naive group</td><td>Treated patients</td><td>STI patients</td></tr><tr><td>Transsexuals</td><td></td><td></td><td>1</td></tr><tr><td>Mean years old</td><td>42</td><td>42</td><td>43</td></tr><tr><td>Geographic origin</td><td></td><td></td><td></td></tr><tr><td>Europeans</td><td>5</td><td>12</td><td>12</td></tr><tr><td>Other/Unknown</td><td>5</td><td>8</td><td>3</td></tr><tr><td>Mean range follow up</td><td></td><td></td><td></td></tr><tr><td>Yearsa</td><td>4 (range 1 – 11) a</td><td>7.5 (range 1 – 15)a</td><td>6 (range 2 – 7) a</td></tr><tr><td>CD4+ count</td><td></td><td></td><td></td></tr><tr><td>cells Γ— 106/l</td><td>Median 391 (range 109–805)</td><td>Median 338 (range 1 – 790)</td><td>Median 717 (range 216 – 1356)</td></tr><tr><td><200 cells Γ— 106/l (Number) b</td><td>1</td><td>6</td><td>0</td></tr><tr><td>Plasma HIV-RNA</td><td></td><td></td><td></td></tr><tr><td>Log10 copies/ml</td><td>Median 4.8 (range 2.7 – 5.4)</td><td>Median 4.4 (range 1.7 – 5.9)</td><td>Median 3.2 (range 1.7 – 4.7) c</td></tr><tr><td><50 copies/ml (Number)b</td><td>0</td><td>5</td><td>3</td></tr><tr><td>HIV1-DNA</td><td></td><td></td><td></td></tr><tr><td>Log10 copies/106 CD4 cells</td><td>Median 3.0 (range 2.6 – 3.7)</td><td>Median 3.3 (range 2.2 – 4.6)</td><td>Median 2.9 (range 2.1 – 4.0)</td></tr><tr><td><5 copies/PCR (Number) b</td><td>6</td><td>12</td><td>5</td></tr></table>