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5574c849fd891f06bb8f91a12403727e84aa9392031efec543b8fc6bb3ad3908.png
simple
<table><tr><td></td><td>Level of guidance</td><td>Nature of guidance</td><td>Health Technology</td></tr><tr><td>Meta regression findings</td><td>Number of sessions not related to outcome</td><td>Better outcomes where guidance provided, and where based on CBT</td><td>No differences between technologies (email, telephone, face to face)</td></tr><tr><td>Meta synthesis findings</td><td>No relevant findings</td><td>No relevant findings</td><td>No relevant findings</td></tr><tr><td>Consensus exercise</td><td>Agreement on timing, duration, and number of sessions</td><td>Agreement that patient preference should determine the nature of guidance</td><td>Agreement that health technology should be accessible, and help with literacy problems.</td></tr><tr><td>Incorporated into the intervention</td><td>3&#8211;10 sessions, 15&#8211;30 minutes duration over 5&#8211;12 weeks</td><td>CBT based. Patient preference delivery of guidance</td><td>Devised a self-help manual and also a CD</td></tr><tr><td></td><td>Who should deliver guided self-help</td><td>Personal experience of depression</td><td>Ambivalent help seeking and covert presentation of problems</td></tr><tr><td>Meta regression findings</td><td>No differences in outcome between professional and paraprofessionals</td><td>No relevant findings</td><td>No relevant findings</td></tr><tr><td>Meta synthesis findings</td><td>No relevant findings</td><td>Personal experience characterised by feeling of inability to cope, and disturbances to functioning. Use of lay language/metaphors important</td><td>Point in illness trajectory where people make service contact, and their prior contact with other help may determine acceptability</td></tr><tr><td>Consensus exercise</td><td>Most frequent were nurses and primary care graduate workers. Specific training needed</td><td>Mixed response to inclusion of lay language and metaphors. Agreement on importance of social functioning, and relapse prevention</td><td>None relevant</td></tr><tr><td>Incorporated into the intervention</td><td>Primary care graduate workers or other mental health professionals</td><td>Emphasised return of social functioning. Lay language, metaphors and causal explanations included. Relapse prevention incorporated</td><td>Expectations and prior contact emphasised and included in the intervention. Choices and patient preference for interventions included</td></tr><tr><td></td><td>Control and helplessness in engaging with treatment</td><td>Stigma associated with treatment</td><td>Patients' understanding of self-help</td></tr><tr><td>Meta regression findings</td><td>No relevant findings</td><td>No relevant findings</td><td>No relevant findings</td></tr><tr><td>Meta synthesis findings</td><td>Patients reported coping strategies such as distraction, or the use of locations associated with feelings of safety and control</td><td>Extent to which guided self-help acknowledges issues of stigma likely to determine acceptability</td><td>Seeing the self as the agent of change may be very important</td></tr><tr><td>Consensus exercise</td><td>Mixed response but emphasis on collaborative working, patient centred goals, and roles i.e. patient as change agent</td><td>None relevant</td><td>Agreement of collaborative working, explicitly detail roles of both patient and MHW i.e. patient as change agent, coach as facilitator</td></tr><tr><td>Incorporated into the intervention</td><td>Highlighting intervention as a method of regaining control and incorporating use of coping strategies termed 'respite' in the intervention</td><td>Discussed guided self-help as requiring a sense of acting on the world and enhancing self-worth</td><td>Explicit team rationale, with the patient as 'team captain', facilitator renamed as 'self-help coach'</td></tr></table>
<table><tr><td></td><td>Level of guidance</td><td>Nature of guidance</td><td>Health Technology</td></tr><tr><td>Meta regression findings</td><td>Number of sessions not related to outcome</td><td>Better outcomes where guidance provided, and where based on CBT</td><td>No differences between technologies (email, telephone, face to face)</td></tr><tr><td>Meta synthesis findings</td><td>No relevant findings</td><td>No relevant findings</td><td>No relevant findings</td></tr><tr><td>Consensus exercise</td><td>Agreement on timing, duration, and number of sessions</td><td>Agreement that patient preference should determine the nature of guidance</td><td>Agreement that health technology should be accessible, and help with literacy problems.</td></tr><tr><td>Incorporated into the intervention</td><td>3–10 sessions, 15–30 minutes duration over 5–12 weeks</td><td>CBT based. Patient preference delivery of guidance</td><td>Devised a self-help manual and also a CD</td></tr><tr><td></td><td>Who should deliver guided self-help</td><td>Personal experience of depression</td><td>Ambivalent help seeking and covert presentation of problems</td></tr><tr><td>Meta regression findings</td><td>No differences in outcome between professional and paraprofessionals</td><td>No relevant findings</td><td>No relevant findings</td></tr></table>
<table><tr><td></td><td>Level of guidance</td><td>Nature of guidance</td><td>Health Technology</td></tr><tr><td>Meta synthesis findings</td><td>No relevant findings</td><td>Personal experience characterised by feeling of inability to cope, and disturbances to functioning. Use of lay language/metaphors important</td><td>Point in illness trajectory where people make service contact, and their prior contact with other help may determine acceptability</td></tr><tr><td>Consensus exercise</td><td>Most frequent were nurses and primary care graduate workers. Specific training needed</td><td>Mixed response to inclusion of lay language and metaphors. Agreement on importance of social functioning, and relapse prevention</td><td>None relevant</td></tr><tr><td>Incorporated into the intervention</td><td>Primary care graduate workers or other mental health professionals</td><td>Emphasised return of social functioning. Lay language, metaphors and causal explanations included. Relapse prevention incorporated</td><td>Expectations and prior contact emphasised and included in the intervention. Choices and patient preference for interventions included</td></tr><tr><td></td><td>Control and helplessness in engaging with treatment</td><td>Stigma associated with treatment</td><td>Patients' understanding of self-help</td></tr><tr><td>Meta regression findings</td><td>No relevant findings</td><td>No relevant findings</td><td>No relevant findings</td></tr><tr><td>Meta synthesis findings</td><td>Patients reported coping strategies such as distraction, or the use of locations associated with feelings of safety and control</td><td>Extent to which guided self-help acknowledges issues of stigma likely to determine acceptability</td><td>Seeing the self as the agent of change may be very important</td></tr><tr><td>Consensus exercise</td><td>Mixed response but emphasis on collaborative working, patient centred goals, and roles i.e. patient as change agent</td><td>None relevant</td><td>Agreement of collaborative working, explicitly detail roles of both patient and MHW i.e. patient as change agent, coach as facilitator</td></tr><tr><td>Incorporated into the intervention</td><td>Highlighting intervention as a method of regaining control and incorporating use of coping strategies termed 'respite' in the intervention</td><td>Discussed guided self-help as requiring a sense of acting on the world and enhancing self-worth</td><td>Explicit team rationale, with the patient as 'team captain', facilitator renamed as 'self-help coach'</td></tr></table>
a8c797c35a78c7c81db9adde869f913ce1dd810d74ac142c9865900ea546971b.png
simple
<table><tr><td>Strain</td><td>Acetate</td><td>Formate</td><td>Succinate</td><td>Ethanol</td><td>Carbon Recovery (%)</td></tr><tr><td><i>E. coli </i>C</td><td>0.95 &#177; 0.08</td><td>1.21 &#177; 0.03</td><td>0.29 &#177; 0.03</td><td>0.58 &#177; 0.05</td><td>100.9 &#177; 0.41</td></tr><tr><td>CCE14</td><td>0.39 &#177; 0.04</td><td>0.67 &#177; 0.04</td><td>0.28 &#177; 0.04</td><td>2.08 &#177; 0.01</td><td>104.5 &#177; 0.22</td></tr><tr><td>KO11</td><td>0.79 &#177; 0.04</td><td>1.59 &#177; 0.06</td><td>ND</td><td>1.63 &#177; 0.01</td><td>98.7 &#177; 0.32</td></tr></table>
<table><tr><td>Strain</td><td>Acetate</td><td>Formate</td><td>Succinate</td><td>Ethanol</td><td>Carbon Recovery (%)</td></tr></table>
<table><tr><td>E. coli C</td><td>0.95 ± 0.08</td><td>1.21 ± 0.03</td><td>0.29 ± 0.03</td><td>0.58 ± 0.05</td><td>100.9 ± 0.41</td></tr><tr><td>CCE14</td><td>0.39 ± 0.04</td><td>0.67 ± 0.04</td><td>0.28 ± 0.04</td><td>2.08 ± 0.01</td><td>104.5 ± 0.22</td></tr><tr><td>KO11</td><td>0.79 ± 0.04</td><td>1.59 ± 0.06</td><td>ND</td><td>1.63 ± 0.01</td><td>98.7 ± 0.32</td></tr></table>
de37ac9c50349b580f8841bcefa36fa729821b8e8be9ec279e05c9d71ba7d763.png
complex
<table><tr><td>Variable</td><td></td><td>Range</td></tr><tr><td>Sex, M/F</td><td colspan="2">33/41</td></tr><tr><td>Age, years</td><td>63.5 &#177; 1.1</td><td>38&#8211;78</td></tr><tr><td>BMI, kg/m<sup>2</sup></td><td>23.0 &#177; 4.0</td><td>13.7&#8211;35.3</td></tr><tr><td>Smoking status, ever/never</td><td colspan="2">31/43</td></tr><tr><td>CTD</td><td colspan="2"></td></tr><tr><td>RA/SSc/PMDM/SjS/MCTD/</td><td colspan="2">24/14/14/11/5</td></tr><tr><td>SLE/overlap syndrome</td><td colspan="2">1/5</td></tr><tr><td>Surgical lung biopsy, yes/no</td><td colspan="2">33/41</td></tr><tr><td>Corticosteroids/immunosuppressant</td><td colspan="2">23/10</td></tr><tr><td>FVC, % predicted</td><td>81.0 &#177; 19.1</td><td>38.3&#8211;127.0</td></tr><tr><td>DLco, % predicted</td><td>57.1 &#177; 19.2</td><td>22.6&#8211;113.6</td></tr><tr><td>RV, % predicted</td><td>81.2 &#177; 31.5</td><td>17.9&#8211;181.9</td></tr><tr><td>TLC, % predicted</td><td>80.3 &#177; 18.3</td><td>47.9&#8211;138.6</td></tr><tr><td>PaO<sub>2,</sub> mmHg</td><td>80.8 &#177; 9.9</td><td>60.2&#8211;103.2</td></tr><tr><td>A-a gradient, mmHg</td><td>20.2 &#177; 11.5</td><td>&#8722;3.8&#8211;38.1</td></tr><tr><td>MPAP, mmHg</td><td>17.2 &#177; 5.5</td><td>8&#8211;36</td></tr><tr><td>CI, l/min/m<sup>2</sup></td><td>3.59 &#177; 0.77</td><td>1.89&#8211;5.18</td></tr><tr><td>PVR, Wood units</td><td>127.3 &#177; 59.9</td><td>34.0&#8211;406.0</td></tr><tr><td>PVRI, Wood units/m<sup>2</sup></td><td>223.5 &#177; 102.1</td><td>52.0&#8211;606.0</td></tr></table>
<table><tr><td>Variable</td><td></td><td>Range</td></tr><tr><td>Sex, M/F</td><td colspan="2">33/41</td></tr><tr><td>Age, years</td><td>63.5 ± 1.1</td><td>38–78</td></tr><tr><td>BMI, kg/m2</td><td>23.0 ± 4.0</td><td>13.7–35.3</td></tr><tr><td>Smoking status, ever/never</td><td colspan="2">31/43</td></tr><tr><td>CTD</td><td colspan="2"></td></tr><tr><td>RA/SSc/PMDM/SjS/MCTD/</td><td colspan="2">24/14/14/11/5</td></tr><tr><td>SLE/overlap syndrome</td><td colspan="2">1/5</td></tr></table>
<table><tr><td>Surgical lung biopsy, yes/no</td><td colspan="2">33/41</td></tr><tr><td>Corticosteroids/immunosuppressant</td><td colspan="2">23/10</td></tr><tr><td>FVC, % predicted</td><td>81.0 ± 19.1</td><td>38.3–127.0</td></tr><tr><td>DLco, % predicted</td><td>57.1 ± 19.2</td><td>22.6–113.6</td></tr><tr><td>RV, % predicted</td><td>81.2 ± 31.5</td><td>17.9–181.9</td></tr><tr><td>TLC, % predicted</td><td>80.3 ± 18.3</td><td>47.9–138.6</td></tr><tr><td>PaO2, mmHg</td><td>80.8 ± 9.9</td><td>60.2–103.2</td></tr><tr><td>A-a gradient, mmHg</td><td>20.2 ± 11.5</td><td>−3.8–38.1</td></tr><tr><td>MPAP, mmHg</td><td>17.2 ± 5.5</td><td>8–36</td></tr><tr><td>CI, l/min/m2</td><td>3.59 ± 0.77</td><td>1.89–5.18</td></tr><tr><td>PVR, Wood units</td><td>127.3 ± 59.9</td><td>34.0–406.0</td></tr><tr><td>PVRI, Wood units/m2</td><td>223.5 ± 102.1</td><td>52.0–606.0</td></tr></table>
afc364620ea78c10082eb5a1f8333c67e826fb69764da602f743811218ef3293.png
simple
<table><tr><td>Characteristic</td><td>Non-pregnant women (n = 12)</td><td>Pregnant women (n = 12)</td><td><i>P</i></td></tr><tr><td>Age, years</td><td>24.5 (5.6)</td><td>26.2 (8.7)</td><td>0.56</td></tr><tr><td>Weight, kg</td><td>59.9 (1.2)</td><td>61.3 (10.1)</td><td>0.77</td></tr><tr><td>Height, cm</td><td>164.5 (7.6)</td><td>166 (7.2)</td><td>0.93</td></tr><tr><td>Gestational age, weeks</td><td>&#8211;</td><td>32.0 (15.0&#8211;40.0)</td><td>&#8211;</td></tr><tr><td>Hemoglobin, g/dL</td><td>10.0 (1.4)</td><td>9.0 (1.0)</td><td>0.05</td></tr><tr><td>Parasite count, rings/&#956;L&#8224;</td><td>14,288 (1,170&#8211;65,000)</td><td>12,642 (1,716&#8211;89,700)</td><td>0.78</td></tr><tr><td>Urea, mg/dL</td><td>25.3 (1.2)</td><td>26.1 (1.5)</td><td>0.16</td></tr><tr><td>Asparate aminotransferase, IU</td><td>4.5 (1.8)</td><td>5.4 (2.4)</td><td>0.31</td></tr><tr><td>Alanine aminotransferase, IU</td><td>12.5 (6.0)</td><td>13.5 (4.7)</td><td>0.65</td></tr></table>
<table><tr><td>Characteristic</td><td>Non-pregnant women (n = 12)</td><td>Pregnant women (n = 12)</td><td>P</td></tr></table>
<table><tr><td>Age, years</td><td>24.5 (5.6)</td><td>26.2 (8.7)</td><td>0.56</td></tr><tr><td>Weight, kg</td><td>59.9 (1.2)</td><td>61.3 (10.1)</td><td>0.77</td></tr><tr><td>Height, cm</td><td>164.5 (7.6)</td><td>166 (7.2)</td><td>0.93</td></tr><tr><td>Gestational age, weeks</td><td>–</td><td>32.0 (15.0–40.0)</td><td>–</td></tr><tr><td>Hemoglobin, g/dL</td><td>10.0 (1.4)</td><td>9.0 (1.0)</td><td>0.05</td></tr><tr><td>Parasite count, rings/μL†</td><td>14,288 (1,170–65,000)</td><td>12,642 (1,716–89,700)</td><td>0.78</td></tr><tr><td>Urea, mg/dL</td><td>25.3 (1.2)</td><td>26.1 (1.5)</td><td>0.16</td></tr><tr><td>Asparate aminotransferase, IU</td><td>4.5 (1.8)</td><td>5.4 (2.4)</td><td>0.31</td></tr><tr><td>Alanine aminotransferase, IU</td><td>12.5 (6.0)</td><td>13.5 (4.7)</td><td>0.65</td></tr></table>
df12d1e444774d83b3ed085a1f48bf400af53fe2877b3d45c8812f8e15dc414d.png
complex
<table><tr><td rowspan="2">Gene</td><td rowspan="2">LTA from strain</td><td rowspan="2">Concentration (&#956;g/mL)</td><td colspan="3">Time</td></tr><tr><td>1 h</td><td>3 h</td><td>24 h</td></tr><tr><td rowspan="4"><i>TNF</i></td><td rowspan="2">233</td><td>1</td><td>4.6 &#177; <i>0.3</i></td><td><i>68</i> &#177; <i>1.8</i></td><td>3.2 &#177; <i>0.2</i></td></tr><tr><td>10</td><td>5.7 &#177; <i>0.0</i></td><td><i>110</i> &#177; <i>2.9</i></td><td>14.1 &#177; <i>0.2</i></td></tr><tr><td rowspan="2">T1&#8211;18</td><td>1</td><td>3.6 &#177; <i>0.3</i></td><td>44 &#177; <i>10.0</i></td><td>2.8 &#177; <i>0.1</i></td></tr><tr><td>10</td><td>6.1 &#177; <i>0.3</i></td><td>114 &#177; <i>2.2</i></td><td>13.4 &#177; <i>0.3</i></td></tr><tr><td rowspan="4"><i>IL6</i></td><td rowspan="2">233</td><td>1</td><td>1.2 &#177; <i>0.0</i></td><td>10.2 &#177; <i>0.8</i></td><td>1.9 &#177; <i>0.1</i></td></tr><tr><td>10</td><td>1.3 &#177; <i>0.1</i></td><td>18.5 &#177; <i>0.2</i></td><td>4.3 &#177; <i>0.04</i></td></tr><tr><td rowspan="2">T1&#8211;18</td><td>1</td><td>1.2 &#177; <i>0.1</i></td><td>7.1 &#177; <i>1.7</i></td><td>1.7 &#177; <i>0.1</i></td></tr><tr><td>10</td><td>1.2 &#177; <i>0.1</i></td><td>18.5 &#177; <i>0.6</i></td><td>4.1 &#177; <i>0.1</i></td></tr><tr><td rowspan="4"><i>CXCL8</i></td><td rowspan="2">233</td><td>1</td><td>2.9 &#177; <i>0.05</i></td><td>38 &#177; <i>2.7</i></td><td>3.2 &#177; <i>0.0</i></td></tr><tr><td>10</td><td>3.2 &#177; <i>0.1</i></td><td>69 &#177; <i>1.1</i></td><td>10.2 &#177; <i>0.2</i></td></tr><tr><td rowspan="2">T1&#8211;18</td><td>1</td><td>2.1 &#177; <i>0.1</i></td><td>25 &#177; <i>4.3</i></td><td>2.5 &#177; <i>0.3</i></td></tr><tr><td>10</td><td>3.2 &#177; <i>0.2</i></td><td>74 &#177; <i>1.7</i></td><td>9.3 &#177; <i>0.1</i></td></tr><tr><td rowspan="4"><i>CCL5</i></td><td rowspan="2">233</td><td>1</td><td>0.9 &#177; <i>0.01</i></td><td>6.6 &#177; <i>0.3</i></td><td>6.0 &#177; <i>0.1</i></td></tr><tr><td>10</td><td>1.1 &#177; <i>0.1</i></td><td>14.7 &#177; <i>0.6</i></td><td>28 &#177; <i>1.1</i></td></tr><tr><td rowspan="2">T1&#8211;18</td><td>1</td><td>1.0 &#177; <i>0.01</i></td><td>3.7 &#177; <i>1.2</i></td><td>4.9 &#177; <i>0.4</i></td></tr><tr><td>10</td><td>1.0 &#177; <i>0.1</i></td><td>13.4 &#177; <i>1.2</i></td><td>33 &#177; <i>2.8</i></td></tr><tr><td rowspan="4"><i>NOS2A</i></td><td rowspan="2">233</td><td>1</td><td>1.0 &#177; <i>0.04</i></td><td>55 &#177; <i>3.2</i></td><td>2.0 &#177; <i>0.1</i></td></tr><tr><td>10</td><td>1.0 &#177; <i>0.02</i></td><td>119 &#177; <i>5.4</i></td><td>7.3 &#177; <i>0.1</i></td></tr><tr><td rowspan="2">T1&#8211;18</td><td>1</td><td>0.9 &#177; <i>0.13</i></td><td>31 &#177; <i>12.8</i></td><td>1.7 &#177; <i>0.1</i></td></tr><tr><td>10</td><td>1.0 &#177; <i>0.05</i></td><td>112 &#177; <i>9.7</i></td><td>6.1 &#177; <i>0.3</i></td></tr><tr><td rowspan="4"><i>LAP</i></td><td rowspan="2">233</td><td>1</td><td>1.0 &#177; <i>0.08</i></td><td>2.9 &#177; <i>0.08</i></td><td>17 &#177; <i>3.5</i></td></tr><tr><td>10</td><td>1.0 &#177; <i>0.04</i></td><td>4.6 &#177; <i>0.48</i></td><td>47 &#177; <i>1.0</i></td></tr><tr><td rowspan="2">T1&#8211;18</td><td>1</td><td>0.9 &#177; <i>0.05</i></td><td>2.2 &#177; <i>0.22</i></td><td>11 &#177; <i>1.4</i></td></tr><tr><td>10</td><td>1.0 &#177; <i>0.04</i></td><td>4.2 &#177; <i>0.03</i></td><td>39 &#177; <i>0.7</i></td></tr><tr><td rowspan="4"><i>SAA3</i></td><td rowspan="2">233</td><td>1</td><td>1.1 &#177; <i>0.02</i></td><td>34 &#177; <i>4.6</i></td><td>31 &#177; <i>2.2</i></td></tr><tr><td>10</td><td>1.1 &#177; <i>0.00</i></td><td>50 &#177; <i>0.6</i></td><td>124 &#177; <i>30</i></td></tr><tr><td rowspan="2">T1&#8211;18</td><td>1</td><td>1.1 &#177; <i>0.02</i></td><td>23 &#177; <i>6.9</i></td><td>45 &#177; <i>8.0</i></td></tr><tr><td>10</td><td>1.2 &#177; <i>0.01</i></td><td>50 &#177; <i>1.6</i></td><td>119 &#177; <i>18</i></td></tr><tr><td rowspan="4"><i>CYP1A1</i></td><td rowspan="2">233</td><td>1</td><td>1.0 &#177; <i>0.02</i></td><td>1.7 &#177; <i>0.1</i></td><td>1.0 &#177; <i>0.04</i></td></tr><tr><td>10</td><td>2.1 &#177; <i>0.03</i></td><td>25 &#177; <i>1.5</i></td><td>1.5 &#177; <i>0.1</i></td></tr><tr><td rowspan="2">T1&#8211;18</td><td>1</td><td>1.0 &#177; <i>0.03</i></td><td>1.4 &#177; <i>0.2</i></td><td>1.3 &#177; <i>0.2</i></td></tr><tr><td>10</td><td>1.8 &#177; <i>0.11</i></td><td>20 &#177; <i>0.6</i></td><td>1.8 &#177; <i>0.1</i></td></tr></table>
<table><tr><td rowspan="2">Gene</td><td rowspan="2">LTA from strain</td><td rowspan="2">Concentration (μg/mL)</td><td colspan="3">Time</td></tr><tr><td>1 h</td><td>3 h</td><td>24 h</td></tr><tr><td>TNF</td><td>233</td><td>1</td><td>4.6 ± 0.3</td><td>68 ± 1.8</td><td>3.2 ± 0.2</td></tr></table>
<table><tr><td rowspan="2">Gene</td><td rowspan="2">LTA from strain</td><td rowspan="2">Concentration (μg/mL)</td><td colspan="3">Time</td></tr><tr><td>1 h</td><td>3 h</td><td>24 h</td></tr><tr><td rowspan="3">TNF</td><td>233</td><td>10</td><td>5.7 ± 0.0</td><td>110 ± 2.9</td><td>14.1 ± 0.2</td></tr><tr><td rowspan="2">T1–18</td><td>1</td><td>3.6 ± 0.3</td><td>44 ± 10.0</td><td>2.8 ± 0.1</td></tr><tr><td>10</td><td>6.1 ± 0.3</td><td>114 ± 2.2</td><td>13.4 ± 0.3</td></tr><tr><td rowspan="4">IL6</td><td rowspan="2">233</td><td>1</td><td>1.2 ± 0.0</td><td>10.2 ± 0.8</td><td>1.9 ± 0.1</td></tr><tr><td>10</td><td>1.3 ± 0.1</td><td>18.5 ± 0.2</td><td>4.3 ± 0.04</td></tr><tr><td rowspan="2">T1–18</td><td>1</td><td>1.2 ± 0.1</td><td>7.1 ± 1.7</td><td>1.7 ± 0.1</td></tr><tr><td>10</td><td>1.2 ± 0.1</td><td>18.5 ± 0.6</td><td>4.1 ± 0.1</td></tr><tr><td rowspan="4">CXCL8</td><td rowspan="2">233</td><td>1</td><td>2.9 ± 0.05</td><td>38 ± 2.7</td><td>3.2 ± 0.0</td></tr><tr><td>10</td><td>3.2 ± 0.1</td><td>69 ± 1.1</td><td>10.2 ± 0.2</td></tr><tr><td rowspan="2">T1–18</td><td>1</td><td>2.1 ± 0.1</td><td>25 ± 4.3</td><td>2.5 ± 0.3</td></tr><tr><td>10</td><td>3.2 ± 0.2</td><td>74 ± 1.7</td><td>9.3 ± 0.1</td></tr><tr><td rowspan="4">CCL5</td><td rowspan="2">233</td><td>1</td><td>0.9 ± 0.01</td><td>6.6 ± 0.3</td><td>6.0 ± 0.1</td></tr><tr><td>10</td><td>1.1 ± 0.1</td><td>14.7 ± 0.6</td><td>28 ± 1.1</td></tr><tr><td rowspan="2">T1–18</td><td>1</td><td>1.0 ± 0.01</td><td>3.7 ± 1.2</td><td>4.9 ± 0.4</td></tr><tr><td>10</td><td>1.0 ± 0.1</td><td>13.4 ± 1.2</td><td>33 ± 2.8</td></tr><tr><td rowspan="4">NOS2A</td><td rowspan="2">233</td><td>1</td><td>1.0 ± 0.04</td><td>55 ± 3.2</td><td>2.0 ± 0.1</td></tr><tr><td>10</td><td>1.0 ± 0.02</td><td>119 ± 5.4</td><td>7.3 ± 0.1</td></tr><tr><td rowspan="2">T1–18</td><td>1</td><td>0.9 ± 0.13</td><td>31 ± 12.8</td><td>1.7 ± 0.1</td></tr><tr><td>10</td><td>1.0 ± 0.05</td><td>112 ± 9.7</td><td>6.1 ± 0.3</td></tr><tr><td rowspan="4">LAP</td><td rowspan="2">233</td><td>1</td><td>1.0 ± 0.08</td><td>2.9 ± 0.08</td><td>17 ± 3.5</td></tr><tr><td>10</td><td>1.0 ± 0.04</td><td>4.6 ± 0.48</td><td>47 ± 1.0</td></tr><tr><td rowspan="2">T1–18</td><td>1</td><td>0.9 ± 0.05</td><td>2.2 ± 0.22</td><td>11 ± 1.4</td></tr><tr><td>10</td><td>1.0 ± 0.04</td><td>4.2 ± 0.03</td><td>39 ± 0.7</td></tr><tr><td rowspan="4">SAA3</td><td rowspan="2">233</td><td>1</td><td>1.1 ± 0.02</td><td>34 ± 4.6</td><td>31 ± 2.2</td></tr><tr><td>10</td><td>1.1 ± 0.00</td><td>50 ± 0.6</td><td>124 ± 30</td></tr><tr><td rowspan="2">T1–18</td><td>1</td><td>1.1 ± 0.02</td><td>23 ± 6.9</td><td>45 ± 8.0</td></tr><tr><td>10</td><td>1.2 ± 0.01</td><td>50 ± 1.6</td><td>119 ± 18</td></tr><tr><td rowspan="4">CYP1A1</td><td rowspan="2">233</td><td>1</td><td>1.0 ± 0.02</td><td>1.7 ± 0.1</td><td>1.0 ± 0.04</td></tr><tr><td>10</td><td>2.1 ± 0.03</td><td>25 ± 1.5</td><td>1.5 ± 0.1</td></tr><tr><td rowspan="2">T1–18</td><td>1</td><td>1.0 ± 0.03</td><td>1.4 ± 0.2</td><td>1.3 ± 0.2</td></tr><tr><td>10</td><td>1.8 ± 0.11</td><td>20 ± 0.6</td><td>1.8 ± 0.1</td></tr></table>
6991298682f0b3327553af06f755e56ac582980b74e1c9f16acf7ff384116c7e.png
complex
<table><tr><td rowspan="2">Environmental variables</td><td colspan="2">Childhood diarrhea</td><td rowspan="2">COR with 95% CI</td><td rowspan="2">AOR with 95% CI</td></tr><tr><td>Yes</td><td>No</td></tr><tr><td colspan="5">Drinking water source</td></tr><tr><td> Protected</td><td>16</td><td>235</td><td>1</td><td></td></tr><tr><td> Unprotected</td><td>168</td><td>285</td><td>8.658(5.040, 14.873)</td><td>2.449(1.264, 4.744)<sup>a</sup></td></tr><tr><td colspan="5">Volume of water collected</td></tr><tr><td>&#8804; 15 L/C/d</td><td>127</td><td>246</td><td>2.482(1.737, 3.546)</td><td>1.535(1.004, 2.346)<sup>a</sup></td></tr><tr><td>&gt; 15 L/C/d</td><td>57</td><td>274</td><td>1</td><td></td></tr><tr><td colspan="5">Water is shared with livestock at the source</td></tr><tr><td> Yes</td><td>163</td><td>211</td><td>11.367(6.985, 18.498)</td><td>4.403(2.424, 7.999)<sup>a</sup></td></tr><tr><td> No</td><td>21</td><td>309</td><td>1</td><td></td></tr><tr><td colspan="5">The water storage container is covered at the time of the survey</td></tr><tr><td> Yes</td><td>2</td><td>24</td><td>1</td><td></td></tr><tr><td> No</td><td>182</td><td>496</td><td>4.403(1.030, 18.818)</td><td>15.681(0.191, 1287.490)</td></tr><tr><td colspan="5">How to withdraw water from the storage</td></tr><tr><td> Pouring</td><td>182</td><td>502</td><td>1</td><td></td></tr><tr><td> Dipping</td><td>2</td><td>18</td><td>0.306(0.070, 1.334)</td><td>16.464(0.191, 1421.947)</td></tr><tr><td colspan="5">Availability of any type of latrine</td></tr><tr><td> Yes</td><td>21</td><td>120</td><td>1</td><td></td></tr><tr><td> No</td><td>163</td><td>400</td><td>2.329(1.415, 3.832)</td><td>2.278(1.045, 4.965)<sup>a</sup></td></tr><tr><td colspan="5">Faeces observed in the compound</td></tr><tr><td> Yes</td><td>179</td><td>457</td><td>4.935(1.953, 12.470)</td><td>11.391(2.100, 61.787)<sup>a</sup></td></tr><tr><td> No</td><td>5</td><td>63</td><td>1</td><td></td></tr><tr><td colspan="5">Hand washing after visiting the toilet</td></tr><tr><td> Yes</td><td>173</td><td>464</td><td>1</td><td></td></tr><tr><td> No</td><td>11</td><td>56</td><td>0.527(0.270, 1.029)</td><td>16.511(3.304, 82.509)<sup>a</sup></td></tr><tr><td colspan="5">Number of rooms</td></tr><tr><td> Only one room</td><td>167</td><td>231</td><td>12.290(7.248, 20.840)</td><td>5.827 (3.208, 10.581)<sup>a</sup></td></tr><tr><td> Two rooms</td><td>17</td><td>289</td><td>1</td><td></td></tr><tr><td colspan="5">Floor type</td></tr><tr><td> Earth floor</td><td>168</td><td>426</td><td>2.317(1.324, 4.053)</td><td>2.039 (0.938, 4.434)</td></tr><tr><td> Cemented floor</td><td>16</td><td>94</td><td>1</td><td></td></tr></table>
<table><tr><td rowspan="2">Environmental variables</td><td colspan="2">Childhood diarrhea</td><td rowspan="2">COR with 95% CI</td><td rowspan="2">AOR with 95% CI</td></tr><tr><td>Yes</td><td>No</td></tr><tr><td colspan="5">Drinking water source</td></tr><tr><td>Protected</td><td>16</td><td>235</td><td>1</td><td></td></tr><tr><td>Unprotected</td><td>168</td><td>285</td><td>8.658(5.040, 14.873)</td><td>2.449(1.264, 4.744)a</td></tr><tr><td colspan="5">Volume of water collected</td></tr><tr><td>≤ 15 L/C/d</td><td>127</td><td>246</td><td>2.482(1.737, 3.546)</td><td>1.535(1.004, 2.346)a</td></tr><tr><td>> 15 L/C/d</td><td>57</td><td>274</td><td>1</td><td></td></tr><tr><td colspan="5">Water is shared with livestock at the source</td></tr><tr><td>Yes</td><td>163</td><td>211</td><td>11.367(6.985, 18.498)</td><td>4.403(2.424, 7.999)a</td></tr><tr><td>No</td><td>21</td><td>309</td><td>1</td><td></td></tr><tr><td colspan="5">The water storage container is covered at the time of the survey</td></tr><tr><td>Yes</td><td>2</td><td>24</td><td>1</td><td></td></tr><tr><td>No</td><td>182</td><td>496</td><td>4.403(1.030, 18.818)</td><td>15.681(0.191, 1287.490)</td></tr><tr><td colspan="5">How to withdraw water from the storage</td></tr></table>
<table><tr><td rowspan="2">Environmental variables</td><td colspan="2">Childhood diarrhea</td><td rowspan="2">COR with 95% CI</td><td rowspan="2">AOR with 95% CI</td></tr><tr><td>Yes</td><td>No</td></tr><tr><td>Pouring</td><td>182</td><td>502</td><td>1</td><td></td></tr><tr><td>Dipping</td><td>2</td><td>18</td><td>0.306(0.070, 1.334)</td><td>16.464(0.191, 1421.947)</td></tr><tr><td colspan="5">Availability of any type of latrine</td></tr><tr><td>Yes</td><td>21</td><td>120</td><td>1</td><td></td></tr><tr><td>No</td><td>163</td><td>400</td><td>2.329(1.415, 3.832)</td><td>2.278(1.045, 4.965)a</td></tr><tr><td colspan="5">Faeces observed in the compound</td></tr><tr><td>Yes</td><td>179</td><td>457</td><td>4.935(1.953, 12.470)</td><td>11.391(2.100, 61.787)a</td></tr><tr><td>No</td><td>5</td><td>63</td><td>1</td><td></td></tr><tr><td colspan="5">Hand washing after visiting the toilet</td></tr><tr><td>Yes</td><td>173</td><td>464</td><td>1</td><td></td></tr><tr><td>No</td><td>11</td><td>56</td><td>0.527(0.270, 1.029)</td><td>16.511(3.304, 82.509)a</td></tr><tr><td colspan="5">Number of rooms</td></tr><tr><td>Only one room</td><td>167</td><td>231</td><td>12.290(7.248, 20.840)</td><td>5.827 (3.208, 10.581)a</td></tr><tr><td>Two rooms</td><td>17</td><td>289</td><td>1</td><td></td></tr><tr><td colspan="5">Floor type</td></tr><tr><td>Earth floor</td><td>168</td><td>426</td><td>2.317(1.324, 4.053)</td><td>2.039 (0.938, 4.434)</td></tr><tr><td>Cemented floor</td><td>16</td><td>94</td><td>1</td><td></td></tr></table>
2b1dcab4b07e7cd5373e93054c36f354f7d49fb41997975b3d6da84d5a8fec04.png
complex
<table><tr><td rowspan="2"></td><td rowspan="2">Survival</td><td colspan="2">Body Weight</td><td rowspan="2">Ascites Fluid (mL) on the 10th Day</td><td rowspan="2">Tumour Cells <sup>b</sup></td><td rowspan="2">Neutrophil <sup>c</sup></td></tr><tr><td>Day 1</td><td>Day 11</td></tr><tr><td>Control EAC</td><td>3/10</td><td>23.1 &#177; 0.6</td><td>29.2 &#177; 0.5</td><td>6.0 &#177; 0.3</td><td>++</td><td>+++</td></tr><tr><td>EAC-5-FU</td><td>8/10</td><td>21.8 &#177; 0.7</td><td>26.3 &#177; 1.1</td><td>4.0 &#177; 0.5</td><td>+</td><td>++</td></tr><tr><td>EAC-HS</td><td>6/10</td><td>22.3 &#177; 0.6</td><td>27.1 &#177; 0.9</td><td>4.5 &#177; 0.4</td><td>+</td><td>++</td></tr><tr><td>EAC-(BDP+5-FU)</td><td>10/10</td><td>22.5 &#177; 0.5</td><td>25.3 &#177; 0.5</td><td>2.3 &#177; 0.6</td><td>-</td><td>+</td></tr><tr><td>EAC-(BDP+HS)</td><td>10/10</td><td>23.0 &#177; 0.5</td><td>26.2 &#177; 0.7</td><td>2.6 &#177; 0.4</td><td>-</td><td>+</td></tr><tr><td>Control</td><td>10/10</td><td>24.5 &#177; 0.4</td><td>25.1 &#177; 0.3</td><td>0</td><td>-</td><td>+</td></tr></table>
<table><tr><td rowspan="2"></td><td rowspan="2">Survival</td><td colspan="2">Body Weight</td><td rowspan="2">Ascites Fluid (mL) on the 10th Day</td><td rowspan="2">Tumour Cells b</td><td rowspan="2">Neutrophil c</td></tr><tr><td>Day 1</td><td>Day 11</td></tr><tr><td>Control EAC</td><td>3/10</td><td>23.1 ± 0.6</td><td>29.2 ± 0.5</td><td>6.0 ± 0.3</td><td>++</td><td>+++</td></tr><tr><td>EAC-5-FU</td><td>8/10</td><td>21.8 ± 0.7</td><td>26.3 ± 1.1</td><td>4.0 ± 0.5</td><td>+</td><td>++</td></tr><tr><td>EAC-HS</td><td>6/10</td><td>22.3 ± 0.6</td><td>27.1 ± 0.9</td><td>4.5 ± 0.4</td><td>+</td><td>++</td></tr><tr><td>EAC-(BDP+5-FU</td><td>10/10</td><td>22.5 </td><td>25.3 ± 0.</td><td>2.3 ± </td><td>-</td><td></td></tr></table>
<table><tr><td rowspan="2"></td><td rowspan="2">Survival</td><td colspan="2">Body Weight</td><td rowspan="2">Ascites Fluid (mL) on the 10th Day</td><td rowspan="2">Tumour Cells b</td><td rowspan="2">Neutrophil c</td></tr><tr><td>Day 1</td><td>Day 11</td></tr><tr><td>)</td><td></td><td>± 0.5</td><td>5</td><td>0.6</td><td></td><td>+</td></tr><tr><td>EAC-(BDP+HS)</td><td>10/10</td><td>23.0 ± 0.5</td><td>26.2 ± 0.7</td><td>2.6 ± 0.4</td><td>-</td><td>+</td></tr><tr><td>Control</td><td>10/10</td><td>24.5 ± 0.4</td><td>25.1 ± 0.3</td><td>0</td><td>-</td><td>+</td></tr></table>
4a20bebb36391381a5c0d7ba59f832dbc6c7e066d2060a03b743aca29e372105.png
complex
<table><tr><td rowspan="2">Locus</td><td rowspan="2">Alleles</td><td colspan="2">Parasitaemia</td><td rowspan="2"><i>&#967;</i>2 significance</td></tr><tr><td>Low (&lt; 1,000/&#956;l)</td><td>Moderate to high (&#8805;1,000/&#956;l)</td></tr><tr><td rowspan="2"><i>Pfcrt </i>76</td><td>Mutant</td><td>8</td><td>31</td><td>&lt;0.001</td></tr><tr><td>Wild</td><td>23</td><td>13</td><td> </td></tr><tr><td rowspan="2"><i>Pfcrt </i>271</td><td>Mutant</td><td>0</td><td>4</td><td>0.138<sup>*</sup></td></tr><tr><td>Wild</td><td>31</td><td>40</td><td> </td></tr><tr><td rowspan="2"><i>Pfcrt </i>326</td><td>Mutant</td><td>0</td><td>9</td><td>0.009<sup>*</sup></td></tr><tr><td>Wild</td><td>31</td><td>35</td><td> </td></tr><tr><td rowspan="2"><i>Pfcrt </i>356</td><td>Mutant</td><td>1</td><td>17</td><td>&lt;0.001<sup>*</sup></td></tr><tr><td>Wild</td><td>30</td><td>27</td><td> </td></tr><tr><td rowspan="2"><i>Pfcrt </i>371</td><td>Mutant</td><td>22</td><td>36</td><td>0.409</td></tr><tr><td>Wild</td><td>9</td><td>8</td><td> </td></tr><tr><td rowspan="2"><i>Pfmdr1 </i>-86</td><td>Mutant</td><td>0</td><td>4</td><td>0.138<sup>*</sup></td></tr><tr><td>Wild</td><td>31</td><td>40</td><td> </td></tr><tr><td><i>Pfmdr1 </i>-1246</td><td>Mutant</td><td>0</td><td>3</td><td>0.263<sup>*</sup></td></tr><tr><td> </td><td>Wild</td><td>31</td><td>41</td><td> </td></tr></table>
<table><tr><td rowspan="2">Locus</td><td rowspan="2">Alleles</td><td colspan="2">Parasitaemia</td><td rowspan="2">χ2 significance</td></tr><tr><td>Low (< 1,000/μl)</td><td>Moderate to high (≥1,000/μl)</td></tr><tr><td rowspan="2">Pfcrt 76</td><td>Mutant</td><td>8</td><td>31</td><td><0.001</td></tr><tr><td>Wild</td><td>23</td><td>13</td><td></td></tr><tr><td rowspan="2">Pfcrt 271</td><td>Mutant</td><td>0</td><td>4</td><td>0.138*</td></tr><tr><td>Wild</td><td>31</td><td>40</td><td></td></tr><tr><td rowspan="2">Pfcrt 326</td><td>Mutant</td><td>0</td><td>9</td><td>0.009*</td></tr><tr><td>Wild</td><td>31</td><td>35</td><td></td></tr></table>
<table><tr><td rowspan="2">Pfcrt 356</td><td>Mutant</td><td>1</td><td>17</td><td><0.001*</td></tr><tr><td>Wild</td><td>30</td><td>27</td><td></td></tr><tr><td rowspan="2">Pfcrt 371</td><td>Mutant</td><td>22</td><td>36</td><td>0.409</td></tr><tr><td>Wild</td><td>9</td><td>8</td><td></td></tr><tr><td rowspan="2">Pfmdr1 -86</td><td>Mutant</td><td>0</td><td>4</td><td>0.138*</td></tr><tr><td>Wild</td><td>31</td><td>40</td><td></td></tr><tr><td>Pfmdr1 -1246</td><td>Mutant</td><td>0</td><td>3</td><td>0.263*</td></tr><tr><td></td><td>Wild</td><td>31</td><td>41</td><td></td></tr></table>
58dd3b85d8dbcc474734599897b37067836b04df9d7b8eba335fa95f0fb3b744.png
simple
<table><tr><td>Data subset</td><td>Accuracy</td><td>Accuracy (%)</td><td>False positives</td><td>False negatives</td><td>MCC score</td></tr><tr><td>All samples</td><td>2290 of 2315</td><td>98.92</td><td>2 of 2159</td><td>23 of 156</td><td>0.91</td></tr><tr><td>EC origin cells</td><td>558 of 564</td><td>98.94</td><td>0 of 535</td><td>6 of 29</td><td>0.89</td></tr><tr><td>EN origin cells</td><td>849 of 857</td><td>99.07</td><td>1 of 790</td><td>7 of 67</td><td>0.93</td></tr><tr><td>M origin cells</td><td>1015 of 1030</td><td>98.54</td><td>3 of 944</td><td>12 of 86</td><td>0.9</td></tr><tr><td>Random non-channel subset</td><td>2221 of 2315</td><td>95.94</td><td>13 of 2006</td><td>81 of 309</td><td>0.81</td></tr></table>
<table><tr><td>Data subset</td><td>Accuracy</td><td>Accuracy (%)</td><td>False positives</td><td>False negatives</td></tr><tr><td>All samples</td><td>2290 of 2315</td><td>98.92</td><td>2 of 2159</td><td>23 of 156</td></tr><tr><td>EC origin cells</td><td>558 of 564</td><td>98.94</td><td>0 of 535</td><td>6 of 29</td></tr><tr><td>EN origin cells</td><td>849 of 857</td><td>99.07</td><td>1 of 790</td><td>7 of 67</td></tr><tr><td>M origin cells</td><td>1015 of 1030</td><td>98.54</td><td>3 of 944</td><td>12 of 86</td></tr><tr><td>Random non-channel subset</td><td>2221 of 2315</td><td>95.94</td><td>13 of 2006</td><td>81 of 309</td></tr></table>
<table><tr><td>MCC score</td></tr><tr><td>0.91</td></tr><tr><td>0.89</td></tr><tr><td>0.93</td></tr><tr><td>0.9</td></tr><tr><td>0.81</td></tr></table>
55114ca33ce625c42df1feedd958a051c4188de2ce34ecc1c8568fc491593056.png
complex
<table><tr><td>Primary antibody</td><td>Host</td><td>Manufacturer; catalog no.; dilution</td><td>Secondary antibody</td></tr><tr><td colspan="4">Enhanced chemiluminescent (ECL) detection</td></tr><tr><td> Anti-phospho-S6 (P-S6) Ser235/236</td><td>Rabbit</td><td>Cell Signaling Technology, Beverly, MA; #4858; 1:500 in 5 % BSA in TBS-T<sup>a</sup></td><td rowspan="6">Anti-rabbit IgG, HRP-conjugated; Cell Signaling Technology, Beverly, MA; #7074; 1:10000 in 5 % nonfat milk in TBS-T</td></tr><tr><td> Anti-S6 (S6)</td><td>Rabbit</td><td>Cell Signaling Technology, Beverly, MA; #2217; 1:1000 in 5 % BSA in TBS-T</td></tr><tr><td> Anti-mTOR</td><td>Rabbit</td><td>Cell Signaling Technology, Beverly, MA; #2983; 1:1000 in 5 % BSA in TBS-T</td></tr><tr><td> Anti-caspase-3</td><td>Rabbit</td><td>Cell Signaling Technology, Beverly, MA; #9662; 1:1000 in 5 % BSA in TBS-T</td></tr><tr><td> Anti-GFP</td><td>Rabbit</td><td>MBL International Corporation, Geel, Belgium; #598; 1:2000 in 5 % nonfat dry milk in TBS-T</td></tr><tr><td> Anti-Elmo1</td><td>Rabbit</td><td>Eurogentec, Liege, Belgium; custom order<sup>b</sup>; 1:500 in 5 % nonfat dry milk in TBS-T</td></tr><tr><td> Anti-&#945;-tubulin</td><td>Mouse</td><td>Sigma-Aldrich, St. Louis, MO; #T5168; 1:20,000 in 5 % nonfat dry milk in TBS-T</td><td>Anti-mouse IgG, HRP-conjugated; Cell Signaling Technology, Beverly, MA; #7076; 1:10000 in 5 % nonfat milk in TBS-T</td></tr><tr><td> Anti-&#946;-actin-HRP</td><td>Mouse</td><td>Sigma-Aldrich, St. Louis, MO; A3854; 1:15,000 in 5 % nonfat dry milk in TBS-T</td><td>N/A</td></tr><tr><td colspan="4">Immunofluorescence</td></tr><tr><td> Anti-phospho-S6 (P-S6) Ser235/236</td><td>Rabbit</td><td>Cell Signaling Technology, Beverly, MA; #4858; 1:200 in 1 % donkey serum in PBS-T<sup>c</sup></td><td rowspan="4">Anti-rabbit IgG Alexa Fluor 488; Life Technologies, Carlsbad, CA; A-21206; 1:500 in 1 % donkey serum in PBS-T</td></tr><tr><td> Anti-c-Fos</td><td>Rabbit</td><td>Santa Cruz Biotechnology, Santa Cruz, CA; #7202; 1:200 in 1 % donkey serum in PBS-T</td></tr><tr><td> Anti-GFAP</td><td>Mouse</td><td>Millipore, Darmstadt, Germany; #04-1031; 1:500 in 1 % donkey serum in PBS-T</td></tr><tr><td> Anti-GFP</td><td>Mouse</td><td>MBL International Corporation, Geel, Belgium; #598; 1:1000 in GDB buffer<sup>d</sup></td></tr></table>
<table><tr><td>Primary antibody</td><td>Host</td><td>Manufacturer; catalog no.; dilution</td><td>Secondary antibody</td></tr><tr><td colspan="4">Enhanced chemiluminescent (ECL) detection</td></tr><tr><td>Anti-phospho-S6 (P-S6) Ser235/236</td><td>Rabbit</td><td>Cell Signaling Technology, Beverly, MA; #4858; 1:500 in 5 % BSA in TBS-Ta</td><td rowspan="6">Anti-rabbit IgG, HRP-conjugated; Cell Signaling Technology, Beverly, MA; #7074; 1:10000 in 5 % nonfat milk in TBS-T</td></tr><tr><td>Anti-S6 (S6)</td><td>Rabbit</td><td>Cell Signaling Technology, Beverly, MA; #2217; 1:1000 in 5 % BSA in TBS-T</td></tr><tr><td>Anti-mTOR</td><td>Rabbit</td><td>Cell Signaling Technology, Beverly, MA; #2983; 1:1000 in 5 % BSA in TBS-T</td></tr><tr><td>Anti-caspase-3</td><td>Rabbit</td><td>Cell Signaling Technology, Beverly, MA; #9662; 1:1000 in 5 % BSA in TBS-T</td></tr><tr><td>Anti-GFP</td><td>Rabbit</td><td>MBL International Corporation, Geel, Belgium; #598; 1:2000 in 5 % nonfat dry milk in TBS-T</td></tr><tr><td>Anti-Elmo1</td><td>Rabbit</td><td>Eurogentec, Liege, Belgium; custom orderb; 1:500 in 5 % nonfat dry milk in TBS-T</td></tr><tr><td>Anti-α-tubulin</td><td>Mouse</td><td>Sigma-Aldrich, St. Louis, MO; #T5168; 1:20,000 in 5 % nonfat dry milk in TBS-T</td><td>Anti-mouse IgG, HRP-conjugated; Cell Signaling Technology, Beverly, MA; #7076; 1:10000 in 5 % nonfat milk in TBS-T</td></tr><tr><td>Anti-β-actin-HRP</td><td>Mouse</td><td>Sigma-Aldrich, St. Louis, MO; A3854; 1:15,000 in 5 % nonfat dry milk in TBS-T</td><td>N/A</td></tr><tr><td colspan="4">Immu</td></tr></table>
<table><tr><td colspan="4">nofluorescence</td></tr><tr><td>Anti-phospho-S6 (P-S6) Ser235/236</td><td>Rabbit</td><td>Cell Signaling Technology, Beverly, MA; #4858; 1:200 in 1 % donkey serum in PBS-Tc</td><td rowspan="4">Anti-rabbit IgG Alexa Fluor 488; Life Technologies, Carlsbad, CA; A-21206; 1:500 in 1 % donkey serum in PBS-T</td></tr><tr><td>Anti-c-Fos</td><td>Rabbit</td><td>Santa Cruz Biotechnology, Santa Cruz, CA; #7202; 1:200 in 1 % donkey serum in PBS-T</td></tr><tr><td>Anti-GFAP</td><td>Mouse</td><td>Millipore, Darmstadt, Germany; #04-1031; 1:500 in 1 % donkey serum in PBS-T</td></tr><tr><td>Anti-GFP</td><td>Mouse</td><td>MBL International Corporation, Geel, Belgium; #598; 1:1000 in GDB bufferd</td></tr></table>
ed0c88b2ac5855482f691b5865740cf08359b8bceffd60218bd7bc789c9e9d85.png
simple
<table><tr><td>Type of study</td><td>Complete articles</td><td>Abstracts</td><td>Total</td><td>No. of Patients</td></tr><tr><td>All studies</td><td>8</td><td>2</td><td>10</td><td>249</td></tr><tr><td>Prospective</td><td>5</td><td>1</td><td>6</td><td>106</td></tr><tr><td>Retrospective</td><td>3</td><td>1</td><td>4</td><td>143</td></tr><tr><td><i>De novo</i> use of RTX</td><td>6</td><td>1</td><td>7</td><td>179</td></tr><tr><td>RTX used for refractory AMR</td><td>2</td><td>1</td><td>3</td><td>70</td></tr><tr><td>Pediatric</td><td>1</td><td>0</td><td>1</td><td>20</td></tr><tr><td>Adult</td><td>7</td><td>2</td><td>9</td><td>229</td></tr></table>
<table><tr><td>Type of study</td><td>Complete articles</td><td>Abstracts</td><td>Total</td><td>No. of Patients</td></tr><tr><td>All studies</td><td>8</td><td>2</td><td>10</td><td>249</td></tr><tr><td>Prospective</td><td>5</td><td>1</td><td>6</td><td>106</td></tr><tr><td>Retrospective</td><td>3</td><td>1</td><td>4</td><td>143</td></tr></table>
<table><tr><td>Type of study</td><td>Complete articles</td><td>Abstracts</td><td>Total</td><td>No. of Patients</td></tr><tr><td>De novo use of RTX</td><td>6</td><td>1</td><td>7</td><td>179</td></tr><tr><td>RTX used for refractory AMR</td><td>2</td><td>1</td><td>3</td><td>70</td></tr><tr><td>Pediatric</td><td>1</td><td>0</td><td>1</td><td>20</td></tr><tr><td>Adult</td><td>7</td><td>2</td><td>9</td><td>229</td></tr></table>
a7a1ec92fa6c6532a6e4c1c77f1ad8fdb972debc3ffb07e26970fe7fea65b418.png
simple
<table><tr><td>Strain</td><td>Maximum specific growth rate (h<sup>-1</sup>)</td></tr><tr><td>HZ848</td><td>0.15 &#177; 0.01</td></tr><tr><td>HZ848-<i>siz1&#916;</i></td><td>0.19 &#177; 0.00</td></tr><tr><td>W303a</td><td>0.19 &#177; 0.01</td></tr><tr><td>W303a-<i>siz1&#916;</i></td><td>0.30 &#177; 0.01</td></tr></table>
<table><tr><td>Strain</td><td>Maximum specific growth rate (h-1)</td></tr><tr><td>HZ848</td><td>0.15 ± 0.01</td></tr></table>
<table><tr><td>Strain</td><td>Maximum specific growth rate (h-1)</td></tr><tr><td>HZ848-siz1Δ</td><td>0.19 ± 0.00</td></tr><tr><td>W303a</td><td>0.19 ± 0.01</td></tr><tr><td>W303a-siz1Δ</td><td>0.30 ± 0.01</td></tr></table>
6c5218046d107a0f51105d41b0aa795682caab8387462a1de007439d584ed961.png
simple
<table><tr><td>Sample</td><td>Size (nm)</td><td>Zeta Potential (mV)</td><td>PdI</td><td>Encapsulation Efficiency (%)</td></tr><tr><td>CNPs</td><td>159.6 &#177; 2.2</td><td>24.50 &#177; 3.64</td><td>0.272 &#177; 0.01</td><td>-</td></tr><tr><td>CNPs/BJ 5</td><td>179.3 &#177; 9.4 **</td><td>23.03 &#177; 3.09</td><td>0.188 &#177; 0.08</td><td>76.7</td></tr><tr><td>CNPs/BJ 10</td><td>174.7 &#177; 5.0 **</td><td>24.91 &#177; 2.91</td><td>0.203 &#177; 0.07</td><td>67.7</td></tr><tr><td>CNPs/BJ 15</td><td>187.3 &#177; 7.5 ***</td><td>31.40 &#177; 3.86</td><td>0.185 &#177; 0.07</td><td>74.0</td></tr><tr><td>CNPs/BE 5</td><td>189.4 &#177; 1.0 ***</td><td>20.71 &#177; 2.93</td><td>0.305 &#177; 0.05</td><td>97.2</td></tr><tr><td>CNPs/BE 10</td><td>160.0 &#177; 2.3</td><td>19.00 &#177; 2.76</td><td>0.302 &#177; 0.01</td><td>87.6</td></tr><tr><td>CNPs/BE 15</td><td>200.3 &#177; 5.6 ***</td><td>27.21 &#177; 1.50</td><td>0.328 &#177; 0.05</td><td>88.1</td></tr></table>
<table><tr><td>Sample</td><td>Size (nm)</td><td>Zeta Potential (mV)</td><td>PdI</td><td>Encapsulation Efficiency (%)</td></tr><tr><td>CNPs</td><td>159.6 ± 2.2</td><td>24.50 ± 3.64</td><td>0.272 ± 0.01</td><td>-</td></tr><tr><td>CNPs/BJ 5</td><td>179.3 ± 9.4 **</td><td>23.03 ± 3.09</td><td>0.188 ± 0.08</td><td>76.7</td></tr><tr><td>CNPs/BJ 10</td><td>174.7 ± 5.0 **</td><td>24.91 ± 2.91</td><td>0.203 ± 0.07</td><td>67.7</td></tr></table>
<table><tr><td>Sample</td><td>Size (nm)</td><td>Zeta Potential (mV)</td><td>PdI</td><td>Encapsulation Efficiency (%)</td></tr><tr><td>CNPs/BJ 15</td><td>187.3 ± 7.5 ***</td><td>31.40 ± 3.86</td><td>0.185 ± 0.07</td><td>74.0</td></tr><tr><td>CNPs/BE 5</td><td>189.4 ± 1.0 ***</td><td>20.71 ± 2.93</td><td>0.305 ± 0.05</td><td>97.2</td></tr><tr><td>CNPs/BE 10</td><td>160.0 ± 2.3</td><td>19.00 ± 2.76</td><td>0.302 ± 0.01</td><td>87.6</td></tr><tr><td>CNPs/BE 15</td><td>200.3 ± 5.6 ***</td><td>27.21 ± 1.50</td><td>0.328 ± 0.05</td><td>88.1</td></tr></table>
738af90e1e18e02df90dcdc241cd4103171418a7d117ee8f9d9e19c0a7da317c.png
simple
<table><tr><td></td><td>Initial polysomnography</td><td>Titration studya</td><td>At therapeutic pressureb</td></tr><tr><td>Time in Bed (min)</td><td>355</td><td>360</td><td>84.5</td></tr><tr><td>Total Sleep Time (min)</td><td>277.5</td><td>253</td><td>83</td></tr><tr><td>Stage N1 (%/min)</td><td>3.6/10</td><td>4/10</td><td>35/29</td></tr><tr><td>Stage N2 (%/minutes)</td><td>29.2/81</td><td>25.1/64</td><td>15/12</td></tr><tr><td>Stage N3 (%/minutes)</td><td>49.5/137</td><td>43.3/110</td><td>~1/&lt;1</td></tr><tr><td>REM (%/minutes)</td><td>17.7/49</td><td>27.7/70</td><td>50/42</td></tr><tr><td>Obstructive Apneas</td><td>23</td><td>1</td><td>0</td></tr><tr><td>Hypopneas</td><td>96</td><td>30</td><td>4</td></tr><tr><td>Central apneas</td><td>39</td><td>14</td><td>1c</td></tr><tr><td>REM central apneas</td><td>39</td><td>14</td><td>1c</td></tr><tr><td>Mixed apneas</td><td>7</td><td>0</td><td>0</td></tr><tr><td>Time below 90% O<sub>2</sub> saturation (%)</td><td>22.9</td><td>4.7</td><td>0</td></tr></table>
<table><tr><td></td><td>Initial polysomnography</td><td>Titration studya</td><td>At therapeutic pressureb</td></tr></table>
<table><tr><td>Time in Bed (min)</td><td>355</td><td>360</td><td>84.5</td></tr><tr><td>Total Sleep Time (min)</td><td>277.5</td><td>253</td><td>83</td></tr><tr><td>Stage N1 (%/min)</td><td>3.6/10</td><td>4/10</td><td>35/29</td></tr><tr><td>Stage N2 (%/minutes)</td><td>29.2/81</td><td>25.1/64</td><td>15/12</td></tr><tr><td>Stage N3 (%/minutes)</td><td>49.5/137</td><td>43.3/110</td><td>~1/<1</td></tr><tr><td>REM (%/minutes)</td><td>17.7/49</td><td>27.7/70</td><td>50/42</td></tr><tr><td>Obstructive Apneas</td><td>23</td><td>1</td><td>0</td></tr><tr><td>Hypopneas</td><td>96</td><td>30</td><td>4</td></tr><tr><td>Central apneas</td><td>39</td><td>14</td><td>1c</td></tr><tr><td>REM central apneas</td><td>39</td><td>14</td><td>1c</td></tr><tr><td>Mixed apneas</td><td>7</td><td>0</td><td>0</td></tr><tr><td>Time below 90% O2 saturation (%)</td><td>22.9</td><td>4.7</td><td>0</td></tr></table>
60cbad6cac08edcb788da8206f477808a74fb8667cff7257f51c694aed3d55c5.png
simple
<table><tr><td></td><td>Function</td><td><i>cis</i> element</td><td>Sequence</td><td>Position</td><td>TF family</td></tr><tr><td>1</td><td>Defense against insect herbivory</td><td>AtMYC2 BS in RD22</td><td>CACATG</td><td>(1578-1583)</td><td>BHLH</td></tr><tr><td>2</td><td>Development</td><td>Bellringer/Replumless /Pennywise</td><td>AAATTAAA</td><td>(2593-2600)</td><td>Homeobox</td></tr><tr><td>3</td><td>Development</td><td>Bellringer/Replumless /Pennywise</td><td>AAATTAGT</td><td>(1368-1375)</td><td>Homeobox</td></tr><tr><td>4</td><td>Development</td><td>Bellringer/Replumless /Pennywise</td><td>ACTAATTT</td><td>(293-300)</td><td>Homeobox</td></tr><tr><td>5</td><td>Response to hiperosmolarity</td><td>ATB2/AtbZIP53/AtbZlP44/GBF5 BS in ProDH</td><td>ACTCAT</td><td>(2537-2542)</td><td>bZIP</td></tr><tr><td>6</td><td>Auxins response</td><td>ARFI binding site motif</td><td>TGTCTC</td><td>(177-182) (1820-1825)</td><td>ARF</td></tr><tr><td>7</td><td>ABA response</td><td>DPBF1&amp;2 binding site motif</td><td>ACACTAG</td><td>(897-904)</td><td>bZIP</td></tr><tr><td>8</td><td></td><td>MYB binding site promoter</td><td>AACCAAAC</td><td>(2359&#8211;2366)</td><td>MYB</td></tr><tr><td>9</td><td>Defense and stress</td><td>MYB4 binding site motif</td><td>AACAAAC</td><td>(825-831) (775-781) (2446-2452)</td><td>MYB4</td></tr><tr><td>10</td><td>Leaf maturation and senescence</td><td>RAVI-A binding site motif</td><td>CAACA</td><td>(1-5) (2138-2142) (1508-1512) (583-587) (360-367)</td><td>ABI3VPl</td></tr><tr><td>11</td><td>Development</td><td>LFY consensus binding site motif</td><td>CCAATG</td><td>(1413-1418)</td><td>LFY</td></tr><tr><td>12</td><td></td><td>Boxll promoter motif</td><td>GGTTAA</td><td>(2810-2815)</td><td></td></tr><tr><td>13</td><td>Drought response</td><td>DRE-like promoter motif</td><td>TACCGACCA</td><td>(533-541)</td><td></td></tr><tr><td>14</td><td>Light response</td><td>GATA promoter motif [LRE]</td><td>TGATAG</td><td>(2957-2962)</td><td></td></tr><tr><td>15</td><td>Light response</td><td>GATA promoter motif [LRE]</td><td>AGATAA</td><td>(287-292) (96-101)</td><td></td></tr><tr><td>16</td><td>Light response</td><td>GATA promoter motif [LRE]</td><td>TGATAA</td><td>(2308-2313)</td><td></td></tr><tr><td>17</td><td></td><td>Hexamer promoter motif</td><td>CCGTCG</td><td>(649-654)</td><td></td></tr><tr><td>18</td><td></td><td>T-box promoter motif</td><td>ACTTIG</td><td>(1529-1534)</td><td></td></tr></table>
<table><tr><td></td><td>Function</td><td>cis element</td><td>Sequence</td><td>Position</td><td>TF family</td></tr><tr><td>1</td><td>Defense against insect herbivory</td><td>AtMYC2 BS in RD22</td><td>CACATG</td><td>(1578-1583)</td><td>BHLH</td></tr><tr><td>2</td><td>Development</td><td>Bellringer/Replumless /Pennywise</td><td>AAATTAAA</td><td>(2593-2600)</td><td>Homeobox</td></tr><tr><td>3</td><td>Development</td><td>Bellringer/Replumless /Pennywise</td><td>AAATTAGT</td><td>(1368-1375)</td><td>Homeobox</td></tr><tr><td>4</td><td>Development</td><td>Bellringer/Replumless /Pennywise</td><td>ACTAATTT</td><td>(293-300)</td><td>Homeobox</td></tr><tr><td>5</td><td>Response to hiperosmolarity</td><td>ATB2/AtbZIP53/AtbZlP44/GBF5 BS in ProDH</td><td>ACTCAT</td><td>(2537-2542)</td><td>bZIP</td></tr><tr><td>6</td><td>Auxins response</td><td>ARFI binding site motif</td><td>TGTCTC</td><td>(177-182) (1820-1825)</td><td>ARF</td></tr><tr><td>7</td><td>ABA response</td><td>DPBF1&2 binding site motif</td><td>ACACTAG</td><td>(897-904)</td><td>bZIP</td></tr><tr><td>8</td><td></td><td>MYB binding site promoter</td><td>AACCAAAC</td><td>(2359–2366)</td><td>MYB</td></tr><tr><td>9</td><td>Defense and stress</td><td>MYB4 binding site motif</td><td>AACAAAC</td><td>(825-831) (775-781) (2446-2452)</td><td>MYB4</td></tr><tr><td>10</td><td>Leaf maturation and senescence</td><td>RAVI-A binding site motif</td><td>CAACA</td><td>(1-5) (2138-2142) (1508-1512) (583-587) (360-367)</td><td>ABI3VPl</td></tr><tr><td>11</td><td>Development</td><td>LFY consensus binding site motif</td><td>CCAATG</td><td>(1413-1418)</td><td>LFY</td></tr><tr><td>12</td><td></td><td>Boxll promoter motif</td><td>GGTTAA</td><td>(2810-2815)</td><td></td></tr><tr><td>13</td><td>Drought response</td><td>DRE-like promoter motif</td><td>TACCGACCA</td><td>(533-541)</td><td></td></tr><tr><td>14</td><td>Light response</td><td>GATA promoter motif [LRE]</td><td>TGATAG</td><td>(2957-2962)</td><td></td></tr></table>
<table><tr><td></td><td>Function</td><td>cis element</td><td>Sequence</td><td>Position</td></tr><tr><td>15</td><td>Light response</td><td>GATA promoter motif [LRE]</td><td>AGATAA</td><td>(287-292) (96-101)</td></tr><tr><td>16</td><td>Light response</td><td>GATA promoter motif [LRE]</td><td>TGATAA</td><td>(2308-2313)</td></tr><tr><td>17</td><td></td><td>Hexamer promoter motif</td><td>CCGTCG</td><td>(649-654)</td></tr><tr><td>18</td><td></td><td>T-box promoter motif</td><td>ACTTIG</td><td>(1529-1534)</td></tr></table>
3d8fca2d982726a037a7fea9d29d0d91b40620af711bd441f29a097e5e1a580e.png
complex
<table><tr><td>Variable</td><td>No. of subjects<sup>a</sup></td><td>HEV antibody prevalence (%)</td><td>Odds ratio (95% CI)</td><td><i>P</i></td></tr><tr><td colspan="4">Age (years)</td><td>&lt;0.008<sup>b</sup></td></tr><tr><td>5-10</td><td>66</td><td>9.1</td><td>1.00</td><td></td></tr><tr><td>11-20</td><td>107</td><td>4.7</td><td>0.49 (0.11-2.03)</td><td></td></tr><tr><td>21-30</td><td>67</td><td>19.4</td><td>2.41 (0.78-8.23)</td><td></td></tr><tr><td>31-50</td><td>101</td><td>17.8</td><td>2.17 (0.76-7.05)</td><td></td></tr><tr><td>&gt;50</td><td>47</td><td>17.0</td><td>2.05 (0.57-7.72)</td><td></td></tr><tr><td>Sex</td><td></td><td></td><td></td><td></td></tr><tr><td>Female</td><td>184</td><td>14.1</td><td>1.23 (0.65-2.34)</td><td>0.290</td></tr><tr><td>Male</td><td>204</td><td>11.8</td><td>1.00</td><td></td></tr><tr><td colspan="5">Past history of hepatitis</td></tr><tr><td>No</td><td>337</td><td>13.3</td><td>1.00</td><td>0.631</td></tr><tr><td>Yes</td><td>52</td><td>9.8</td><td>0.71 (0.21-1.91)</td><td></td></tr><tr><td colspan="4">Education of household head (years of schooling)</td><td>0.046<sup>b</sup></td></tr><tr><td>0</td><td>81</td><td>18.5</td><td>2.73 (0.80-11.92)</td><td></td></tr><tr><td>1-4</td><td>174</td><td>13.2</td><td>1.83 (0.58-7.61)</td><td></td></tr><tr><td>5-8</td><td>81</td><td>9.9</td><td>1.32 (0.33-6.29)</td><td></td></tr><tr><td>&gt;8</td><td>52</td><td>7.7</td><td>1.00</td><td></td></tr><tr><td colspan="5">Wealth index (quartiles)<sup>c</sup></td></tr><tr><td>1 (poorest)</td><td>109</td><td>12.8</td><td>1.60 (0.57-4.92)</td><td>0.497<sup>b</sup></td></tr><tr><td>2</td><td>98</td><td>14.3</td><td>1.81 (0.64-5.57)</td><td></td></tr><tr><td>3</td><td>98</td><td>15.3</td><td>1.96 (0.70-5.99)</td><td></td></tr><tr><td>4 (least poor)</td><td>83</td><td>8.4</td><td>1.00</td><td></td></tr><tr><td colspan="5">Water source</td></tr><tr><td>Well</td><td>366</td><td>13.4</td><td>1.00</td><td>0.382</td></tr><tr><td>River/stream</td><td>22</td><td>4.5</td><td>0.31 (0.01-2.01)</td><td></td></tr><tr><td colspan="5">Drinking water filtrated or chlorinated</td></tr><tr><td>Yes</td><td>302</td><td>13.2</td><td>1.00</td><td>0.961</td></tr><tr><td>No</td><td>72</td><td>13.9</td><td>1.06 (0.45-2.30)</td><td></td></tr><tr><td colspan="5">Crowding (number of inhabitants/room)</td></tr><tr><td>&lt;1</td><td>161</td><td>13.7</td><td>1.00</td><td>0.673<sup>b</sup></td></tr><tr><td>1-1.9</td><td>181</td><td>12.1</td><td>0.87 (0.44-1.73)</td><td></td></tr><tr><td>2-3</td><td>22</td><td>18.2</td><td>1.40 (0.32-4.83)</td><td></td></tr><tr><td>&gt;3</td><td>24</td><td>8.3</td><td>0.57 (0.06-2.63)</td><td></td></tr></table>
<table><tr><td>Variable</td><td>No. of subjectsa</td><td>HEV antibody prevalence (%)</td><td>Odds ratio (95% CI)</td><td>P</td></tr><tr><td colspan="4">Age (years)</td><td><0.008b</td></tr><tr><td>5-10</td><td>66</td><td>9.1</td><td>1.00</td><td></td></tr><tr><td>11-20</td><td>107</td><td>4.7</td><td>0.49 (0.11-2.03)</td><td></td></tr><tr><td>21-30</td><td>67</td><td>19.4</td><td>2.41 (0.78-8.23)</td><td></td></tr><tr><td>31-50</td><td>101</td><td>17.8</td><td>2.17 (0.76-7.05)</td><td></td></tr><tr><td>>50</td><td>47</td><td>17.0</td><td>2.05 (0.57-7.72)</td><td></td></tr><tr><td>Sex</td><td></td><td></td><td></td><td></td></tr><tr><td>Female</td><td>184</td><td>14.1</td><td>1.23 (0.65-2.34)</td><td>0.290</td></tr><tr><td>Male</td><td>204</td><td>11.8</td><td>1.00</td><td></td></tr><tr><td colspan="5">Past history of hepatitis</td></tr></table>
<table><tr><td>Variable</td><td>No. of subjectsa</td><td>HEV antibody prevalence (%)</td><td>Odds ratio (95% CI)</td><td>P</td></tr><tr><td>No</td><td>337</td><td>13.3</td><td>1.00</td><td>0.631</td></tr><tr><td>Yes</td><td>52</td><td>9.8</td><td>0.71 (0.21-1.91)</td><td></td></tr><tr><td colspan="4">Education of household head (years of schooling)</td><td>0.046b</td></tr><tr><td>0</td><td>81</td><td>18.5</td><td>2.73 (0.80-11.92)</td><td></td></tr><tr><td>1-4</td><td>174</td><td>13.2</td><td>1.83 (0.58-7.61)</td><td></td></tr><tr><td>5-8</td><td>81</td><td>9.9</td><td>1.32 (0.33-6.29)</td><td></td></tr><tr><td>>8</td><td>52</td><td>7.7</td><td>1.00</td><td></td></tr><tr><td colspan="5">Wealth index (quartiles)c</td></tr><tr><td>1 (poorest)</td><td>109</td><td>12.8</td><td>1.60 (0.57-4.92)</td><td>0.497b</td></tr><tr><td>2</td><td>98</td><td>14.3</td><td>1.81 (0.64-5.57)</td><td></td></tr><tr><td>3</td><td>98</td><td>15.3</td><td>1.96 (0.70-5.99)</td><td></td></tr><tr><td>4 (least poor)</td><td>83</td><td>8.4</td><td>1.00</td><td></td></tr><tr><td colspan="5">Water source</td></tr><tr><td>Well</td><td>366</td><td>13.4</td><td>1.00</td><td>0.382</td></tr><tr><td>River/stream</td><td>22</td><td>4.5</td><td>0.31 (0.01-2.01)</td><td></td></tr><tr><td colspan="5">Drinking water filtrated or chlorinated</td></tr><tr><td>Yes</td><td>302</td><td>13.2</td><td>1.00</td><td>0.961</td></tr><tr><td>No</td><td>72</td><td>13.9</td><td>1.06 (0.45-2.30)</td><td></td></tr><tr><td colspan="5">Crowding (number of inhabitants/room)</td></tr><tr><td><1</td><td>161</td><td>13.7</td><td>1.00</td><td>0.673b</td></tr><tr><td>1-1.9</td><td>181</td><td>12.1</td><td>0.87 (0.44-1.73)</td><td></td></tr><tr><td>2-3</td><td>22</td><td>18.2</td><td>1.40 (0.32-4.83)</td><td></td></tr><tr><td>>3</td><td>24</td><td>8.3</td><td>0.57 (0.06-2.63)</td><td></td></tr></table>
24d1a44055003f63cb13441e7d2e28de4d10cfbeb4a126f1f0c8923a9b484887.png
simple
<table><tr><td>Region</td><td>States in region</td><td>Selected states, medical colleges, and cities</td></tr><tr><td>North</td><td>Delhi, Rajasthan, Jammu and Kashmir, Himachal Pradesh, Punjab, Haryana, Uttarakhand and Chandigarh</td><td>NCT of Delhi (Lady Harding Medical College, Delhi), Rajasthan (NIMS Medical College and Hospital, Jaipur)</td></tr><tr><td>South</td><td>Tamil Nadu, Karnataka, Kerala, Andhra Pradesh, Puducherry, Lakshadweep, Andaman and Nicobar</td><td>Karnataka (Kasturba Medical College, Manipal), Tamil Nadu (Madras Medical College, Chennai)</td></tr><tr><td>East</td><td>Sikkim, Assam, Tripura, Manipur, Nagaland, Arunachal Pradesh, Mizoram, Meghalaya, Bihar, Jharkhand, West-Bengal and Orissa</td><td>Manipur (Regional Institute Medical Sciences, Imphal), Orissa (Kalinga Institute of Medical Sciences, Odisha)</td></tr><tr><td>West</td><td>Dadar and Nagar Haveli, Daman and Diu, Goa, Maharashtra and Gujarat</td><td>Gujarat (M.P. Shah Medical College, Jamnagar), Maharashtra (L.T.M. Medical College and General Hospital, Mumbai)</td></tr><tr><td>Central</td><td>Uttar Pradesh, Chhattisgarh, and Madhya Pradesh</td><td>Uttar Pradesh (Integral Institute of Medical Sciences and Research, Lucknow), Madhya Pradesh (G.R. Medical College, Gwalior)</td></tr></table>
<table><tr><td>Region</td><td>States in region</td><td>Selected states, medical colleges, and cities</td></tr><tr><td>North</td><td>Delhi, Rajasthan, Jammu and Kashmir, Himachal Pradesh, Punjab, Haryana, Uttarakhand and Chandigarh</td><td>NCT of Delhi (Lady Harding Medical College, Delhi), Rajasthan (NIMS Medical College and Hospital, Jaipur)</td></tr><tr><td>South</td><td>Tamil Nadu, Karnataka, Kerala, Andhra Pradesh, Puducherry, Lakshadweep, Andaman and Nicobar</td><td>Karnataka (Kasturba Medical College, Manipal), Tamil Nadu (Madras Medical College, Chennai)</td></tr><tr><td>East</td><td>Sikkim, Assam, Tripura, Manipur, Nagaland, Arunachal Pradesh, Mizoram, Meghalaya, Bihar, Jharkhand, West-Bengal and Orissa</td><td>Manipur (Regional Institute Medical Sciences, Imphal), Orissa (Kalinga Institute of Medical Sciences, Odisha)</td></tr><tr><td>West</td><td>Dadar and Nagar Haveli, Daman and Diu, Goa, Maharashtra and Gujarat</td><td>Gujarat (M.P. Shah Medical College, Jamnagar), Maharashtra (L.T.M. Medical College and General Hospital, Mumbai)</td></tr><tr><td>Cent</td><td></td><td>Uttar Pradesh (Integral Institute of Medic</td></tr></table>
<table><tr><td>Region</td><td>States in region</td><td>Selected states, medical colleges, and cities</td></tr><tr><td>ral</td><td>Uttar Pradesh, Chhattisgarh, and Madhya Pradesh</td><td>al Sciences and Research, Lucknow), Madhya Pradesh (G.R. Medical College, Gwalior)</td></tr></table>
42bb3d48db603ef502e86169b7f0dab68a79a1b03d1bcbab6c1d1397a93a21dd.png
simple
<table><tr><td>Risk Factor Goals</td><td> </td></tr><tr><td>Blood Pressure</td><td>BP 130/80 mmHg</td></tr><tr><td>Diabetes Mellitus</td><td>Fasting or pre-prandial glucose of 4-6, or a HbA1C &lt; 6.5%</td></tr><tr><td>Lipids</td><td>Total cholesterol less than 4 mmol/l or an LDL &lt; 2.0 mmol/l</td></tr><tr><td>Smoking</td><td>Smoking cessation</td></tr><tr><td>Weight</td><td>BMI &lt; 25</td></tr></table>
<table><tr><td>Risk Factor Goals</td><td></td></tr><tr><td>Blood Pressure</td><td>BP 130/80 mmHg</td></tr><tr><td>Diabetes Mellitus</td><td>Fasting or pre-prandial glucose of 4-6, or a HbA1C < 6.5%</td></tr><tr><td>Lipids</td><td>Total cholesterol less than 4 mmol/l or an LDL < 2.0 mmol/l</td></tr></table>
<table><tr><td>Smoking</td><td>Smoking cessation</td></tr><tr><td>Weight</td><td>BMI < 25</td></tr></table>
a58ed84831fbd18d7d29a5a38dcc127ab0f19cdc0f7237b11dc780ae47b4b845.png
complex
<table><tr><td>Strain</td><td>SC 5314</td><td><i>opt1</i>&#916;</td><td><i>opt2</i>&#916; <i>opt3</i>&#916;</td><td><i>opt4</i>&#916;</td><td><i>opt5</i>&#916;</td><td><i>opt1&#8211;opt5</i>&#916;</td><td><i>ptr2</i>&#916; <i>ptr22</i>&#916;</td><td><i>opt1&#8211;opt5</i>&#916; <i>ptr2</i>&#916; <i>ptr22</i>&#916;</td></tr><tr><td>Peptide</td><td colspan="6">MIC (&#956;g mL<sup>-1</sup>)</td></tr><tr><td>F2</td><td>0.25</td><td>0.25</td><td>0.25</td><td>0.25</td><td>0.25</td><td>0.5</td><td>&gt;128</td><td>&gt;128</td></tr><tr><td>F3</td><td>0.25</td><td>0.5</td><td>0.5</td><td>0.5</td><td>0.5</td><td>1</td><td>&gt;128</td><td>&gt;128</td></tr><tr><td>F6</td><td>4</td><td>8</td><td>32</td><td>8</td><td>8</td><td>&gt;128</td><td>4</td><td>&gt;128</td></tr><tr><td>F7</td><td>16</td><td>32</td><td>&gt;&gt;128</td><td>32</td><td>32</td><td>&gt;128</td><td>16</td><td>&gt;128</td></tr><tr><td>P10</td><td>64</td><td>64</td><td>64</td><td>64</td><td>64</td><td>64</td><td>64</td><td>64</td></tr><tr><td>F11</td><td>16</td><td>32</td><td>128</td><td>32</td><td>16</td><td>&gt;128</td><td>16</td><td>&gt;128</td></tr></table>
<table><tr><td>Strain</td><td>SC 5314</td><td>opt1Δ</td><td>opt2Δ opt3Δ</td><td>opt4Δ</td><td>opt5Δ</td><td>opt1–opt5Δ</td><td>ptr2Δ ptr22Δ</td><td>opt1–opt5Δ ptr2Δ ptr22Δ</td></tr><tr><td>Peptide</td><td colspan="6">MIC (μg mL-1)</td><td colspan="2"></td></tr></table>
<table><tr><td>Strain</td><td>SC 5314</td><td>opt1Δ</td><td>opt2Δ opt3Δ</td><td>opt4Δ</td><td>opt5Δ</td><td>opt1–opt5Δ</td><td>ptr2Δ ptr22Δ</td><td>opt1–opt5Δ ptr2Δ ptr22Δ</td></tr><tr><td>F2</td><td>0.25</td><td>0.25</td><td>0.25</td><td>0.25</td><td>0.25</td><td>0.5</td><td>>128</td><td>>128</td></tr><tr><td>F3</td><td>0.25</td><td>0.5</td><td>0.5</td><td>0.5</td><td>0.5</td><td>1</td><td>>128</td><td>>128</td></tr><tr><td>F6</td><td>4</td><td>8</td><td>32</td><td>8</td><td>8</td><td>>128</td><td>4</td><td>>128</td></tr><tr><td>F7</td><td>16</td><td>32</td><td>>>128</td><td>32</td><td>32</td><td>>128</td><td>16</td><td>>128</td></tr><tr><td>P10</td><td>64</td><td>64</td><td>64</td><td>64</td><td>64</td><td>64</td><td>64</td><td>64</td></tr><tr><td>F11</td><td>16</td><td>32</td><td>128</td><td>32</td><td>16</td><td>>128</td><td>16</td><td>>128</td></tr></table>
7f03e2189e80e1bf088cdccd48a708a3fc1d0d81b90263978a722112cdba9939.png
complex
<table><tr><td rowspan="2">Regimens</td><td rowspan="2">n (<i>n</i> = 612)</td><td colspan="2">CINV [n (%)]</td></tr><tr><td>Grade 0-II (<i>n</i> = 339)</td><td>Grade III-IV (<i>n</i> = 273)</td></tr><tr><td>CAF</td><td>59</td><td>36 (61.0)</td><td>23 (39.0)</td></tr><tr><td>CEF</td><td>107</td><td>59 (55.1)</td><td>48 (44.9)</td></tr><tr><td>TEC</td><td>57</td><td>29 (50.9)</td><td>28 (49.1)</td></tr><tr><td>TE</td><td>122</td><td>74 (60.7)</td><td>48 (39.3)</td></tr><tr><td>TAC</td><td>61</td><td>40 (65.6)</td><td>21 (34.4)</td></tr><tr><td>TA</td><td>51</td><td>24 (47.1)</td><td>27 (52.9)</td></tr><tr><td>AC</td><td>40</td><td>21 (52.5)</td><td>19 (47.5)</td></tr><tr><td>EC</td><td>115</td><td>56 (48.7)</td><td>59 (51.3)</td></tr></table>
<table><tr><td rowspan="2">Regimens</td><td rowspan="2">n (n = 612)</td><td colspan="2">CINV [n (%)]</td></tr><tr><td>Grade 0-II (n = 339)</td><td>Grade III-IV (n = 273)</td></tr><tr><td>CAF</td><td>59</td><td>36 (61.0)</td><td>23 (39.0)</td></tr><tr><td>CEF</td><td>107</td><td>59 (55.1)</td><td>48 (44.9)</td></tr><tr><td>TEC</td><td>57</td><td>29 (50.9)</td><td>28 (49.1)</td></tr><tr><td>T</td><td>122</td><td></td><td>48</td></tr></table>
<table><tr><td>E</td><td></td><td>74 (60.7)</td><td> (39.3)</td></tr><tr><td>TAC</td><td>61</td><td>40 (65.6)</td><td>21 (34.4)</td></tr><tr><td>TA</td><td>51</td><td>24 (47.1)</td><td>27 (52.9)</td></tr><tr><td>AC</td><td>40</td><td>21 (52.5)</td><td>19 (47.5)</td></tr><tr><td>EC</td><td>115</td><td>56 (48.7)</td><td>59 (51.3)</td></tr></table>
32313a8f1a531abbec902f3c7da41ab23a54efb7d047f98a5adff3d40e386a33.png
simple
<table><tr><td>Compositional Category</td><td>Features in Chloroplast</td></tr><tr><td>CP genome length (nt)</td><td>155,989</td></tr><tr><td>LSC length (nt)</td><td>85,912</td></tr><tr><td>SSC length (nt)</td><td>17,517</td></tr><tr><td>IR length (Ira/b) (nt)</td><td>52,560</td></tr><tr><td>AT/GC contents (%)</td><td>62.34/37.66</td></tr><tr><td>No. of total/unique genes</td><td>129/111</td></tr><tr><td>Genic occupancy (nt)</td><td>88,065</td></tr><tr><td>Intergenic occupancy (nt)</td><td>67,924</td></tr><tr><td>Protein-coding genes</td><td>78</td></tr><tr><td>Transfer RNAs (tRNAs)</td><td>29</td></tr><tr><td>Ribosomal RNAs (rRNAs)</td><td>4</td></tr><tr><td>No. of genes duplicated in IR regions</td><td>16</td></tr><tr><td>Total number of genes with intron(s)</td><td>17</td></tr><tr><td>Gene(s) with single intron</td><td>14</td></tr><tr><td>Gene(s) with multiple introns</td><td>3</td></tr><tr><td>tRNAs with intron(s)</td><td>5</td></tr></table>
<table><tr><td>Compositional Category</td></tr><tr><td>CP genome length (nt)</td></tr><tr><td>LSC length (nt)</td></tr><tr><td>SSC length (nt)</td></tr><tr><td>IR length (Ira/b) (nt)</td></tr><tr><td>AT/GC contents (%)</td></tr><tr><td>No. of total/unique genes</td></tr><tr><td>Genic occupancy (nt)</td></tr><tr><td>Intergenic occupancy (nt)</td></tr><tr><td>Protein-coding genes</td></tr><tr><td>Transfer RNAs (tRNAs)</td></tr><tr><td>Ribosomal RNAs (rRNAs)</td></tr><tr><td>No. of genes duplicated in IR regions</td></tr><tr><td>Total number of genes with intron(s)</td></tr><tr><td>Gene(s) with single intron</td></tr><tr><td>Gene(s) with multiple introns</td></tr><tr><td>tRNAs with intron(s)</td></tr></table>
<table><tr><td>Features in Chloroplast</td></tr><tr><td>155,989</td></tr><tr><td>85,912</td></tr><tr><td>17,517</td></tr><tr><td>52,560</td></tr><tr><td>62.34/37.66</td></tr><tr><td>129/111</td></tr><tr><td>88,065</td></tr><tr><td>67,924</td></tr><tr><td>78</td></tr><tr><td>29</td></tr><tr><td>4</td></tr><tr><td>16</td></tr><tr><td>17</td></tr><tr><td>14</td></tr><tr><td>3</td></tr><tr><td>5</td></tr></table>
ac2fa693db5668b828ea44972262bb3cb745c047d462f4b154dc4aa56d85bdf3.png
simple
<table><tr><td>Data Set</td><td>Score Used</td><td>Positive</td><td>Negative</td><td>Close to Zero</td><td>Total Tested</td></tr><tr><td>Ma&#8211;Mu</td><td>Sum of signs of translation shift scores</td><td>597</td><td>569</td><td>58</td><td>16,942</td></tr><tr><td>Fa&#8211;Fu</td><td>Sum of signs of translation shift scores</td><td>48</td><td>60</td><td>5</td><td>15,045</td></tr><tr><td>Fa&#8211;Fu</td><td>Count of CpG</td><td>84</td><td>85</td><td>15</td><td>12,491</td></tr></table>
<table><tr><td>Data Set</td><td>Score Used</td></tr><tr><td>Ma–Mu</td><td>Sum of signs of translation shift scores</td></tr><tr><td>Fa–Fu</td><td>Sum of signs of translation shift scores</td></tr><tr><td>Fa–Fu</td><td>Count of CpG</td></tr></table>
<table><tr><td>Positive</td><td>Negative</td><td>Close to Zero</td><td>Total Tested</td></tr><tr><td>597</td><td>569</td><td>58</td><td>16,942</td></tr><tr><td>48</td><td>60</td><td>5</td><td>15,045</td></tr><tr><td>84</td><td>85</td><td>15</td><td>12,491</td></tr></table>
debaf094842b117771787ab6cba7457f84ebc7551b92e1027d9c54f47710a8ff.png
simple
<table><tr><td></td><td>no DM</td><td>DM</td><td><i>P</i></td></tr><tr><td>XMP</td><td>13 585 (8 386, 29 579)</td><td>62 101 (14 261, 158 938)</td><td>5.0E-7*</td></tr><tr><td>VMA</td><td>173 153 (107 165, 279 690)</td><td>104 186 (67 902, 164 683)</td><td>1.5E-6*</td></tr><tr><td>Glucose</td><td>2 935 (1 046, 5 294)</td><td>6 245 (2 777, 9 807)</td><td>3.1E-6*</td></tr><tr><td>3-PG</td><td>2 475 150 (1 882 036, 333 2264)</td><td>3 767 372 (2 250 378, 5 598 373)</td><td>4.9E-5*</td></tr><tr><td>Methionine</td><td>195 026 (152 633, 239 841)</td><td>243 230 (195 219, 283 910)</td><td>4.5E-5*</td></tr><tr><td>Adenosine</td><td>1 942 (1 463, 3 457)</td><td>3 078 (1 706, 5 137)</td><td>8.6E-4</td></tr><tr><td>mevalonate-5P</td><td>192 139 (136 927, 291 930)</td><td>292 904 (165 128, 433 871)</td><td>2.8E-4*</td></tr><tr><td>ornithine</td><td>1 385 224 (1 083 311, 1 721 772)</td><td>1 657 626 (1 351 270, 1 913 549)</td><td>3.2E-4*</td></tr><tr><td>uracil</td><td>6 888 567 (4 490 348, 9 622 913)</td><td>4 784 283 (3 740 917, 6 592 407)</td><td>5.7E-4</td></tr><tr><td>lactose</td><td>3 140 699 (2 178 153, 4 835 219)</td><td>4 519 336 (2 900 447, 6 650 384)</td><td>3.8E-4</td></tr><tr><td>xanthosine</td><td>10 839 (7 518, 22 311)</td><td>22 007 (8 845, 36 474)</td><td>1.0E-3</td></tr><tr><td>tyrosine</td><td>222 479 (174 354, 277 562)</td><td>247 875 (210 621, 309 004)</td><td>2.2E-3</td></tr><tr><td>serine</td><td>352 671 (280 146, 415 607)</td><td>381 134 (319 491, 476 035)</td><td>4.6E-3</td></tr><tr><td>PEP</td><td>312 003 (189 719, 522 172)</td><td>462 016 (257 705, 925 860)</td><td>1.3E-3</td></tr><tr><td>ribose-5-P-rib</td><td>144 443 (104 797, 208 719)</td><td>180 078 (116 088, 322 799)</td><td>8.7E-3</td></tr></table>
<table><tr><td></td><td>no DM</td><td>DM</td><td>P</td></tr><tr><td>XMP</td><td>13 585 (8 386, 29 579)</td><td>62 101 (14 261, 158 938)</td><td>5.0E-7*</td></tr><tr><td>VMA</td><td>173 153 (107 165, 279 690)</td><td>104 186 (67 902, 164 683)</td><td>1.5E-6*</td></tr><tr><td>Glucose</td><td>2 935 (1 046, 5 294)</td><td>6 245 (2 777, 9 807)</td><td>3.1E-6*</td></tr><tr><td>3-PG</td><td>2 475 150 (1 882 036, 333 2264)</td><td>3 767 372 (2 250 378, 5 598 373)</td><td>4.9E-5*</td></tr><tr><td>Methionine</td><td>195 026 (152 633, 239 841)</td><td>243 230 (195 219, 283 910)</td><td>4.5E-5*</td></tr><tr><td>Adenosine</td><td>1 942 (1 463, 3 457)</td><td>3 078 (1 706, 5 137)</td><td>8.6E-4</td></tr><tr><td>mevalonate-5P</td><td>192 139 (136 927, 291 930)</td><td>292 904 (165 128, 433 871)</td><td>2.8E-4*</td></tr><tr><td>ornithine</td><td>1 385 224 (1 083 311, 1 721 772)</td><td>1 657 626 (1 351 270, 1 913 549)</td><td>3.2E-4*</td></tr><tr><td>uracil</td><td>6 888 567 (4 490 348, 9 622 913)</td><td>4 784 283 (3 740 917, 6 592 407)</td><td>5.7E-4</td></tr><tr><td>lactose</td><td>3 140 699 (2 178 153, 4 835 219)</td><td>4 519 336 (2 900 447, 6 650 384)</td><td>3.8E-4</td></tr><tr><td>xanthosine</td><td>10 839 (7 518, 22 311)</td><td>22 007 (8 845, 36 474)</td><td>1.0E-3</td></tr><tr><td>tyrosine</td><td>222 479 (174 354, 277 562)</td><td>247 875 (210 621, 309 004)</td><td>2.2E-3</td></tr><tr><td>serine</td><td>352 671 (280 146, 415 607)</td><td>381 134 (319 491, 476 035)</td><td>4.6E-3</td></tr></table>
<table><tr><td></td><td>no DM</td><td>DM</td><td>P</td></tr><tr><td>PEP</td><td>312 003 (189 719, 522 172)</td><td>462 016 (257 705, 925 860)</td><td>1.3E-3</td></tr><tr><td>ribose-5-P-rib</td><td>144 443 (104 797, 208 719)</td><td>180 078 (116 088, 322 799)</td><td>8.7E-3</td></tr></table>
c5bbe42885c2f7bb30627d4bc71bd1369a1d1a16fa67dc520033d338efbb5fc1.png
simple
<table><tr><td>Participant</td><td>Outcome measure</td><td>Instrument</td><td>baseline</td><td>3 months</td><td>6 months</td></tr><tr><td>Patient</td><td>Self-perceived performance in daily activities<sup>a</sup></td><td>Canadian Occupational Performance Measure (COPM; performance rating) [25]</td><td><i>&#8730;</i></td><td><i>&#8730;</i></td><td><i>&#8730;</i></td></tr><tr><td> </td><td>Self-perceived satisfaction with performance in daily activities</td><td>Canadian Occupational Performance Measure (COPM; satisfaction rating) [25]</td><td><i>&#8730;</i></td><td><i>&#8730;</i></td><td><i>&#8730;</i></td></tr><tr><td> </td><td>Objective performance in daily activities</td><td>Perceive Recall Plan Perform system (PRPP) [26]</td><td><i>&#8730;</i></td><td><i>&#8730;</i></td><td>-</td></tr><tr><td> </td><td>Participation</td><td>Activity Card Sort (ACS) [27,28]</td><td><i>&#8730;</i></td><td><i>&#8730;</i></td><td>-</td></tr><tr><td> </td><td> </td><td>Utrecht Scale for Evaluation of Rehabilitation Participation (USER-P; satisfaction part) [29,30]</td><td><i>&#8730;</i></td><td><i>&#8730;</i></td><td><i>&#8730;</i></td></tr><tr><td> </td><td>Health-related quality of life</td><td>Parkinson&#8217;s Disease Questionnaire (PDQ-39) [31-33]</td><td><i>&#8730;</i></td><td><i>&#8730;</i></td><td><i>&#8730;</i></td></tr><tr><td> </td><td>Impact of fatigue</td><td>Fatigue Severity Scale (FSS) [34,35]</td><td><i>&#8730;</i></td><td><i>&#8730;</i></td><td><i>&#8730;</i></td></tr><tr><td> </td><td>Mood</td><td>Becks Depression Inventory (BDI) [36]</td><td><i>&#8730;</i></td><td><i>&#8730;</i></td><td><i>&#8730;</i></td></tr><tr><td>Caregiver</td><td>Perceived caregiver burden</td><td>Zarit Burden Interview (ZBI) [37]</td><td><i>&#8730;</i></td><td><i>&#8730;</i></td><td><i>&#8730;</i></td></tr><tr><td> </td><td>Objective caregiver burden</td><td>Objective care burden questionnaire; hours of care</td><td><i>&#8730;</i></td><td><i>&#8730;</i></td><td><i>&#8730;</i></td></tr><tr><td> </td><td>Mood</td><td>Hospital Anxiety and Depression Scale (HADS) [38]</td><td><i>&#8730;</i></td><td><i>&#8730;</i></td><td><i>&#8730;</i></td></tr><tr><td>Both</td><td>Quality of life</td><td>Euroqol EQ-5 D [39]</td><td><i>&#8730;</i></td><td>-</td><td><i>&#8730;</i></td></tr><tr><td> </td><td>Quality of life overall</td><td>Visual Analogue Scale for Quality of life; VAS QoL</td><td><i>&#8730;</i></td><td><i>&#8730;</i></td><td><i>&#8730;</i></td></tr><tr><td> </td><td>Proactive coping</td><td>Utrecht Proactive Coping Competence scale (UPCC) [40]</td><td><i>&#8730;</i></td><td><i>&#8730;</i></td><td><i>&#8730;</i></td></tr><tr><td> </td><td>Resource utilization</td><td>Resource utilization questionnaire: patient and caregiver version</td><td><i>&#8730;</i></td><td><i>&#8730;</i></td><td><i>&#8730;</i></td></tr></table>
<table><tr><td>Participant</td><td>Outcome measure</td><td>Instrument</td><td>baseline</td><td>3 months</td><td>6 months</td></tr><tr><td>Patient</td><td>Self-perceived performance in daily activitiesa</td><td>Canadian Occupational Performance Measure (COPM; performance rating) [25]</td><td>√</td><td>√</td><td>√</td></tr><tr><td></td><td>Self-perceived satisfaction with performance in daily activities</td><td>Canadian Occupational Performance Measure (COPM; satisfaction rating) [25]</td><td>√</td><td>√</td><td>√</td></tr><tr><td></td><td>Objective performance in daily activities</td><td>Perceive Recall Plan Perform system (PRPP) [26]</td><td>√</td><td>√</td><td>-</td></tr><tr><td></td><td>Participation</td><td>Activity Card Sort (ACS) [27,28]</td><td>√</td><td>√</td><td>-</td></tr><tr><td></td><td></td><td>Utrecht Scale for Evaluation of Rehabilitation Participation (USER-P; satisfaction part) [29,30]</td><td>√</td><td>√</td><td>√</td></tr><tr><td></td><td>Health-related quality of life</td><td>Parkinson’s Disease Questionnaire (PDQ-39) [31-33]</td><td>√</td><td>√</td><td>√</td></tr><tr><td></td><td>Impact of fatigue</td><td>Fatigue Severity Scale (FSS) [34,35]</td><td>√</td><td>√</td><td>√</td></tr><tr><td></td><td>Mood</td><td>Becks Depression Inventory (BDI) [36]</td><td>√</td><td>√</td><td>√</td></tr><tr><td>Caregiver</td><td>Perceived caregiver burden</td><td>Zarit Burden Interview (ZBI) [37]</td><td>√</td><td>√</td><td>√</td></tr><tr><td></td><td>Objective caregiver burden</td><td>Objective care burden questionnaire; hours of care</td><td>√</td><td>√</td><td>√</td></tr><tr><td></td><td>Mood</td><td>Hospital Anxiety and Depression Scale (HADS) [38]</td><td>√</td><td>√</td><td>√</td></tr><tr><td>Both</td><td>Quality of life</td><td>Euroqol EQ-5 D [39]</td><td>√</td><td>-</td><td>√</td></tr><tr><td></td><td>Quality of life overall</td><td>Visual Analogue Scale for Quality of life; VAS QoL</td><td>√</td><td>√</td><td>√</td></tr></table>
<table><tr><td></td><td>Proactive coping</td><td>Utrecht Proactive Coping Competence scale (UPCC) [40]</td><td>√</td><td>√</td><td>√</td></tr><tr><td></td><td>Resource utilization</td><td>Resource utilization questionnaire: patient and caregiver version</td><td>√</td><td>√</td><td>√</td></tr></table>
a4cc5d8dd1107397cb9b3b5e6d86e03451b33badcc0ecf2e60f23303ce311d2f.png
simple
<table><tr><td>Birth defects</td><td>Number of cases</td><td>Birth prevalence/10,000 and 95%CI</td></tr><tr><td>Anencephaly</td><td>0</td><td>0 (0&#8211;6.3)</td></tr><tr><td>Spin bifida</td><td>1</td><td>1.7 (0&#8211;9.5)</td></tr><tr><td>Encephalocele</td><td>0</td><td>0 (0&#8211;6.3)</td></tr><tr><td>Microcephaly</td><td>1</td><td>1.7 (0&#8211;9.5)</td></tr><tr><td>Arhinencephaly/holoprosencephaly</td><td>4</td><td>6.8 (1.9&#8211;17.4)</td></tr><tr><td>Hydrocephaly</td><td>4</td><td>6.8 (1.9&#8211;17.4)</td></tr><tr><td>Buphtalmos</td><td>1</td><td>1.7 (0&#8211;9.5)</td></tr><tr><td>Congenital cataract</td><td>2</td><td>3.4 (0.4&#8211;12.3)</td></tr><tr><td>Anotia/microtia</td><td>1</td><td>1.7 (0&#8211;9.5)</td></tr><tr><td>Transposition of great vessels</td><td>4</td><td>6.8 (1.9&#8211;17.4)</td></tr><tr><td>Tetralogy of Fallot</td><td>2</td><td>3.4 (0.4&#8211;12.3)</td></tr><tr><td>Ventricular septal defect</td><td>42</td><td>71.3 (51.4&#8211;96.4)</td></tr><tr><td>Atrial septal defect</td><td>4</td><td>6.8 (1.9&#8211;17.4)</td></tr><tr><td>Endocardial cushion defects</td><td>3</td><td>5.1 (1.1&#8211;14.9)</td></tr><tr><td>Ebstein's anomaly</td><td>1</td><td>1.7 (0&#8211;9.5)</td></tr><tr><td>Hypoplastic left heart syndrome</td><td>0</td><td>0 (0&#8211;6.3)</td></tr><tr><td>Coarctation of aorta</td><td>3</td><td>5.1 (1.1&#8211;14.9)</td></tr><tr><td>Choanal atresia, bilateral</td><td>0</td><td>0 (0&#8211;6.3)</td></tr><tr><td>Cleft palate without cleft lip</td><td>1</td><td>1.7 (0&#8211;9.5)</td></tr><tr><td>Cleft lip with or without cleft palate</td><td>2</td><td>3.4 (0.4&#8211;12.3)</td></tr><tr><td>Oesophageal atresia/stenosis</td><td>4</td><td>6.8 (1.9&#8211;17.4)</td></tr><tr><td>Congenital hypertrophic pyloric stenosis</td><td>1</td><td>1.7 (0&#8211;9.5)</td></tr><tr><td>Small intestine atresia/stenosis</td><td>0</td><td>0 (0&#8211;6.3)</td></tr><tr><td>Anorectal atresia/stenosis</td><td>1</td><td>1.7 (0&#8211;9.5)</td></tr><tr><td>Hirschsprung's disease</td><td>1</td><td>1.7 (0&#8211;9.5)</td></tr><tr><td>Anomalies of intestinal fixation</td><td>0</td><td>0 (0&#8211;6.3)</td></tr><tr><td>Hypospadias</td><td></td><td></td></tr><tr><td>Indeterminate sex</td><td>0</td><td>0 (0&#8211;6.3)</td></tr><tr><td>Renal agenesis</td><td>1</td><td>1.7 (0&#8211;9.5)</td></tr><tr><td>Cystic kidney</td><td>3</td><td>5.1 (1.1&#8211;14.9)</td></tr><tr><td>Bladder exstrophy</td><td>0</td><td>0 (0&#8211;6.3)</td></tr><tr><td>Polydactyly and syndactyly</td><td>4</td><td>6.8 (1.9&#8211;17.4)</td></tr><tr><td>Total limb reduction defects</td><td>Not analysed</td><td>Not analysed</td></tr><tr><td>Diaphragmatic hernia</td><td>1</td><td>1.7 (0&#8211;9.5)</td></tr><tr><td>Omphalocele</td><td>0</td><td>0 (0&#8211;6.3)</td></tr><tr><td>Gastroschisis</td><td>0</td><td>0 (0&#8211;6.3)</td></tr><tr><td>Trisomy 13</td><td>0</td><td>0 (0&#8211;6.3)</td></tr><tr><td>Trisomy 18</td><td>0</td><td>0 (0&#8211;6.3)</td></tr><tr><td>Down syndrome</td><td>6</td><td>10.2 (3.7&#8211;22.2)</td></tr><tr><td>Prader Willi syndrome</td><td>0</td><td>0 (0&#8211;6.3)</td></tr><tr><td>Total</td><td>98</td><td>166.4</td></tr></table>
<table><tr><td>Birth defects</td></tr><tr><td>Anencephaly</td></tr><tr><td>Spin bifida</td></tr><tr><td>Encephalocele</td></tr><tr><td>Microcephaly</td></tr><tr><td>Arhinencephaly/holoprosencephaly</td></tr><tr><td>Hydrocephaly</td></tr><tr><td>Buphtalmos</td></tr><tr><td>Congenital cataract</td></tr><tr><td>Anotia/microtia</td></tr><tr><td>Transposition of great vessels</td></tr><tr><td>Tetralogy of Fallot</td></tr><tr><td>Ventricular septal defect</td></tr><tr><td>Atrial septal defect</td></tr><tr><td>Endocardial cushion defects</td></tr><tr><td>Ebstein's anomaly</td></tr><tr><td>Hypoplastic left heart syndrome</td></tr><tr><td>Coarctation of aorta</td></tr><tr><td>Choanal atresia, bilateral</td></tr><tr><td>Cleft palate without cleft lip</td></tr><tr><td>Cleft lip with or without cleft palate</td></tr><tr><td>Oesophageal atresia/stenosis</td></tr><tr><td>Congenital hypertrophic pyloric stenosis</td></tr><tr><td>Small intestine atresia/stenosis</td></tr><tr><td>Anorectal atresia/stenosis</td></tr><tr><td>Hirschsprung's disease</td></tr><tr><td>Anomalies of intestinal fixation</td></tr><tr><td>Hypospadias</td></tr><tr><td>Indeterminate sex</td></tr><tr><td>Renal agenesis</td></tr><tr><td>Cystic kidney</td></tr><tr><td>Bladder exstrophy</td></tr><tr><td>Polydactyly and syndactyly</td></tr><tr><td>Total limb reduction defects</td></tr><tr><td>Diaphragmatic hernia</td></tr><tr><td>Omphalocele</td></tr><tr><td>Gastroschisis</td></tr><tr><td>Trisomy 13</td></tr><tr><td>Trisomy 18</td></tr><tr><td>Down syndrome</td></tr><tr><td>Prader Willi syndrome</td></tr><tr><td>Total</td></tr></table>
<table><tr><td>Number of cases</td><td>Birth prevalence/10,000 and 95%CI</td></tr><tr><td>0</td><td>0 (0–6.3)</td></tr><tr><td>1</td><td>1.7 (0–9.5)</td></tr><tr><td>0</td><td>0 (0–6.3)</td></tr><tr><td>1</td><td>1.7 (0–9.5)</td></tr><tr><td>4</td><td>6.8 (1.9–17.4)</td></tr><tr><td>4</td><td>6.8 (1.9–17.4)</td></tr><tr><td>1</td><td>1.7 (0–9.5)</td></tr><tr><td>2</td><td>3.4 (0.4–12.3)</td></tr><tr><td>1</td><td>1.7 (0–9.5)</td></tr><tr><td>4</td><td>6.8 (1.9–17.4)</td></tr><tr><td>2</td><td>3.4 (0.4–12.3)</td></tr><tr><td>42</td><td>71.3 (51.4–96.4)</td></tr><tr><td>4</td><td>6.8 (1.9–17.4)</td></tr><tr><td>3</td><td>5.1 (1.1–14.9)</td></tr><tr><td>1</td><td>1.7 (0–9.5)</td></tr><tr><td>0</td><td>0 (0–6.3)</td></tr><tr><td>3</td><td>5.1 (1.1–14.9)</td></tr><tr><td>0</td><td>0 (0–6.3)</td></tr><tr><td>1</td><td>1.7 (0–9.5)</td></tr><tr><td>2</td><td>3.4 (0.4–12.3)</td></tr><tr><td>4</td><td>6.8 (1.9–17.4)</td></tr><tr><td>1</td><td>1.7 (0–9.5)</td></tr><tr><td>0</td><td>0 (0–6.3)</td></tr><tr><td>1</td><td>1.7 (0–9.5)</td></tr><tr><td>1</td><td>1.7 (0–9.5)</td></tr><tr><td>0</td><td>0 (0–6.3)</td></tr><tr><td></td><td></td></tr><tr><td>0</td><td>0 (0–6.3)</td></tr><tr><td>1</td><td>1.7 (0–9.5)</td></tr><tr><td>3</td><td>5.1 (1.1–14.9)</td></tr><tr><td>0</td><td>0 (0–6.3)</td></tr><tr><td>4</td><td>6.8 (1.9–17.4)</td></tr><tr><td>Not analysed</td><td>Not analysed</td></tr><tr><td>1</td><td>1.7 (0–9.5)</td></tr><tr><td>0</td><td>0 (0–6.3)</td></tr><tr><td>0</td><td>0 (0–6.3)</td></tr><tr><td>0</td><td>0 (0–6.3)</td></tr><tr><td>0</td><td>0 (0–6.3)</td></tr><tr><td>6</td><td>10.2 (3.7–22.2)</td></tr><tr><td>0</td><td>0 (0–6.3)</td></tr><tr><td>98</td><td>166.4</td></tr></table>
33f123bb47ff71273479911248f9f17ed8eca24cd556f8d3dfa1505f33a1cdcc.png
simple
<table><tr><td></td><td>T2DM</td><td>T2DM + MC</td><td>Control</td></tr><tr><td>Gender (M/F)</td><td>73/39</td><td>77/41</td><td>37/23</td></tr><tr><td>Age (years)</td><td>75.1 &#177; 2.1</td><td>76.1 &#177; 3.1</td><td>73.3 &#177; 6.2</td></tr><tr><td>Duration (years)</td><td>15.2 &#177; 4.3</td><td>16.8 &#177; 3.4</td><td>NA</td></tr><tr><td>BMI (kg/m<sup>2</sup>)</td><td>26.17 &#177; 3.83<sup>&#9733;</sup></td><td>27.10 &#177; 4.01<sup>&#9733;</sup></td><td>23.13 &#177; 3.83</td></tr><tr><td>WHR</td><td>0.94 &#177; 0.63<sup>&#9733;</sup></td><td>0.98 &#177; 0.31<sup>&#9733;</sup></td><td>0.85 &#177; 0.07</td></tr><tr><td>SBP (mmHg)</td><td>137 &#177; 9<sup>&#9733;</sup></td><td>143 &#177; 13<sup>&#9733;</sup></td><td>123 &#177; 16</td></tr><tr><td>DBP (mmHg)</td><td>69 &#177; 6</td><td>67 &#177; 6</td><td>65 &#177; 7</td></tr><tr><td>AF, <i>n</i></td><td>34</td><td>45</td><td>12</td></tr><tr><td>CKD, <i>n</i></td><td>33<sup>&#9733;</sup></td><td>45<sup>&#9733;</sup></td><td>10</td></tr><tr><td>CHD, <i>n</i></td><td>37<sup>&#9733;</sup></td><td>55<sup>&#9733;&#9679;</sup></td><td>16</td></tr><tr><td>1</td><td>64</td><td>45</td><td>None</td></tr><tr><td>2</td><td>33</td><td>47</td><td>None</td></tr><tr><td>3</td><td>13</td><td>28<sup>&#9679;</sup></td><td>None</td></tr></table>
<table><tr><td></td><td>T2DM</td><td>T2DM + MC</td><td>Control</td></tr><tr><td>Gender (M/F)</td><td>73/39</td><td>77/41</td><td>37/23</td></tr><tr><td>Age (years)</td><td>75.1 ± 2.1</td><td>76.1 ± 3.1</td><td>73.3 ± 6.2</td></tr><tr><td>Duration (years)</td><td>15.2 ± 4.3</td><td>16.8 ± 3.4</td><td>NA</td></tr><tr><td>BMI (kg/m2)</td><td>26.17 ± 3.83★</td><td>27.10 ± 4.01★</td><td>23.13 ± 3.83</td></tr><tr><td>WHR</td><td>0.94 ± 0.63★</td><td>0.98 ± 0.31★</td><td>0.85 ± 0.07</td></tr><tr><td>SBP (mmHg)</td><td>137 ± 9★</td><td>143 ± 13★</td><td>123 ± 16</td></tr><tr><td>DBP (mmHg)</td><td>69 ± 6</td><td>67 ± 6</td><td>65 ± 7</td></tr><tr><td>AF, n</td><td>34</td><td>45</td><td>12</td></tr><tr><td>CKD, n</td><td>33★</td><td>45★</td><td>10</td></tr></table>
<table><tr><td></td><td>T2DM</td><td>T2DM + MC</td><td>Control</td></tr><tr><td>CHD, n</td><td>37★</td><td>55★●</td><td>16</td></tr><tr><td>1</td><td>64</td><td>45</td><td>None</td></tr><tr><td>2</td><td>33</td><td>47</td><td>None</td></tr><tr><td>3</td><td>13</td><td>28●</td><td>None</td></tr></table>
1c2ac7248e4f39c53b5439817ee5e5f42a4884eece93e6895d736b471a64ad27.png
simple
<table><tr><td>User</td><td>Dice</td><td>ASSD(mm)</td><td><i>&#954;</i></td></tr><tr><td>1</td><td>0.81&#177;0.02</td><td>2.73&#177;0.62</td><td>0.931</td></tr><tr><td>2</td><td>0.82&#177;0.03</td><td>2.57&#177;0.60</td><td>0.936</td></tr><tr><td>3</td><td>0.81&#177;0.03</td><td>2.75&#177;0.61</td><td>0.949</td></tr><tr><td>4</td><td>0.80&#177;0.03</td><td>2.81&#177;0.73</td><td>0.941</td></tr><tr><td>5</td><td>0.82&#177;0.02</td><td>2.58&#177;0.61</td><td>0.948</td></tr><tr><td>6</td><td>0.82&#177;0.02</td><td>2.63&#177;0.61</td><td>0.945</td></tr><tr><td>7</td><td>0.82&#177;0.02</td><td>2.61&#177;0.74</td><td>0.941</td></tr><tr><td>8</td><td>0.81&#177;0.03</td><td>2.76&#177;0.67</td><td>0.936</td></tr><tr><td>All</td><td>0.82&#177;0.02</td><td>2.67&#177;0.63</td><td>0.932</td></tr></table>
<table><tr><td>User</td><td>Dice</td></tr><tr><td>1</td><td>0.81±0.02</td></tr><tr><td>2</td><td>0.82±0.03</td></tr><tr><td>3</td><td>0.81±0.03</td></tr><tr><td>4</td><td>0.80±0.03</td></tr><tr><td>5</td><td>0.82±0.02</td></tr><tr><td>6</td><td>0.82±0.02</td></tr><tr><td>7</td><td>0.82±0.02</td></tr><tr><td>8</td><td>0.81±0.03</td></tr><tr><td>All</td><td>0.82±0.02</td></tr></table>
<table><tr><td>ASSD(mm)</td><td>κ</td></tr><tr><td>2.73±0.62</td><td>0.931</td></tr><tr><td>2.57±0.60</td><td>0.936</td></tr><tr><td>2.75±0.61</td><td>0.949</td></tr><tr><td>2.81±0.73</td><td>0.941</td></tr><tr><td>2.58±0.61</td><td>0.948</td></tr><tr><td>2.63±0.61</td><td>0.945</td></tr><tr><td>2.61±0.74</td><td>0.941</td></tr><tr><td>2.76±0.67</td><td>0.936</td></tr><tr><td>2.67±0.63</td><td>0.932</td></tr></table>
638ce509484805367dc1aeabdc44c73ec0b99fa05b2374a9c9f32d6cf28dab15.png
complex
<table><tr><td rowspan="2">Service area</td><td colspan="3">Number of MNH providers observed</td><td colspan="3">Number of provider-client interactions observed</td><td colspan="3">Intraclass Correlation Coefficient (ICC)</td></tr><tr><td>Total</td><td>Inter-vention group</td><td>Com-parison group</td><td>Total</td><td>Inter-vention group</td><td>Com-parison group</td><td>Cluster level</td><td>Inter-vention group</td><td>Com-parison group</td></tr><tr><td>ANC</td><td>63</td><td>29</td><td>34</td><td>232</td><td>118</td><td>114</td><td>Facility</td><td>0.551</td><td>0.458</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>Provider</td><td>0.763</td><td>0.667</td></tr><tr><td>Labor &amp; delivery</td><td>117</td><td>57</td><td>60</td><td>226</td><td>123</td><td>123</td><td>Facility</td><td>0.632</td><td>0.474</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>Provider</td><td>0.775</td><td>0.454</td></tr><tr><td>PNC</td><td>109</td><td>57</td><td>52</td><td>229</td><td>119</td><td>110</td><td>Facility</td><td>0.530</td><td>0.573</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>Provider</td><td>0.658</td><td>0.574</td></tr></table>
<table><tr><td rowspan="2">Service area</td><td colspan="3">Number of MNH providers observed</td><td colspan="3">Number of provider-client interactions observed</td><td colspan="3">Intraclass Correlation Coefficient (ICC)</td></tr><tr><td>Total</td><td>Inter-vention group</td><td>Com-parison group</td><td>Total</td><td>Inter-vention group</td><td>Com-parison group</td><td>Cluster level</td><td>Inter-vention group</td><td>Com-parison group</td></tr><tr><td>ANC</td><td>63</td><td>29</td><td>34</td><td>232</td><td>118</td><td>114</td><td>Facility</td><td>0.551</td><td>0.458</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>Provider</td><td>0.763</td><td>0.667</td></tr><tr><td>Labor & delivery</td><td>117</td><td>57</td><td>60</td><td>226</td><td>123</td><td>123</td><td>Facility</td><td>0.632</td><td>0.474</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>Provider</td><td>0.775</td><td>0.454</td></tr><tr><td>PNC</td><td>109</td><td>57</td><td>52</td><td>229</td><td>119</td><td>110</td><td>Facility</td><td>0.530</td><td>0.573</td></tr></table>
<table><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>Provider</td><td>0.658</td><td>0.574</td></tr></table>
bc92e9b8771a43500f2f3ae057f1dbaea4bab5ac09d81013dc4d6602318b1d48.png
complex
<table><tr><td></td><td colspan="3">Females</td><td colspan="3">Males</td></tr><tr><td>Gene</td><td>Coefficient estimate</td><td>Standard error</td><td><i>P</i>-value</td><td>Coefficient estimate</td><td>Standard error</td><td><i>P</i>-value</td></tr><tr><td><i>AQP9</i></td><td>0.411</td><td>0.133</td><td>0.003**</td><td>0.028</td><td>0.156</td><td>0.857</td></tr><tr><td><i>AS3MT</i></td><td>&#8722;0.115</td><td>0.074</td><td>0.126</td><td>0.058</td><td>0.082</td><td>0.483</td></tr><tr><td><i>GSTM1</i></td><td>0.107</td><td>0.435</td><td>0.806</td><td>&#8722;0.279</td><td>0.506</td><td>0.584</td></tr><tr><td><i>SLC39A2</i></td><td>&#8722;0.105</td><td>0.101</td><td>0.300</td><td>&#8722;0.015</td><td>0.089</td><td>0.870</td></tr></table>
<table><tr><td></td><td colspan="2">Females</td></tr><tr><td>Gene</td><td>Coefficient estimate</td><td>Standard error</td></tr><tr><td>AQP9</td><td>0.411</td><td>0.133</td></tr><tr><td>AS3MT</td><td>−0.115</td><td>0.074</td></tr><tr><td>GSTM1</td><td>0.107</td><td>0.435</td></tr><tr><td>SLC39A2</td><td>−0.105</td><td>0.101</td></tr></table>
<table><tr><td>Females</td><td colspan="3">Males</td></tr><tr><td>P-value</td><td>Coefficient estimate</td><td>Standard error</td><td>P-value</td></tr><tr><td>0.003**</td><td>0.028</td><td>0.156</td><td>0.857</td></tr><tr><td>0.126</td><td>0.058</td><td>0.082</td><td>0.483</td></tr><tr><td>0.806</td><td>−0.279</td><td>0.506</td><td>0.584</td></tr><tr><td>0.300</td><td>−0.015</td><td>0.089</td><td>0.870</td></tr></table>
3a7b7d5abfe5a3a52458cc75a4aa0b8e2dd627e2dee87a63bd6434fd62e3c5d4.png
simple
<table><tr><td>Anti-VLY scFv</td><td>Expression level, % of total cell protein</td><td>Oligomeric state</td><td>Activity (%) after 12 months storage at 4&#176;C</td></tr><tr><td>scFv 9B4 (VL-VH)</td><td>20-30</td><td>monomeric</td><td>100</td></tr><tr><td>scFv 9B4 (VH-VL)</td><td>20-30</td><td>monomeric</td><td>100</td></tr><tr><td>scFv 23A2 (VL-VH)</td><td>20-30</td><td>monomeric</td><td>75</td></tr><tr><td>scFv 23A2 (VH-VL)</td><td>20-30</td><td>monomeric</td><td>75</td></tr></table>
<table><tr><td>Anti-VLY scFv</td><td>Expression level, % of total cell protein</td><td>Oligomeric state</td><td>Activity (%) after 12 months storage at 4°C</td></tr><tr><td>scFv 9B4 (VL-VH)</td><td>20-30</td><td>monomeric</td><td>100</td></tr><tr><td>scFv 9B4 (VH-VL)</td><td>20-30</td><td>monomeric</td><td>100</td></tr><tr><td>scFv 23A2 (VL-VH)</td><td>20-30</td><td>monomeric</td><td>75</td></tr></table>
<table><tr><td>scFv 23A2 (VH-VL)</td><td>20-30</td><td>monomeric</td><td>75</td></tr></table>
03b5d3a0fbca9312ebcad5b365154cb854c5c4296b1a352e28238208dfaf1574.png
simple
<table><tr><td></td><td>Plasma membrane number / %</td><td>Intracellular number / %</td><td>Total immunogold number / %</td></tr><tr><td>P7</td></tr><tr><td><i>Dendritic spines</i></td><td>88/7,6</td><td>107/9,2</td><td>195/16,9</td></tr><tr><td><i>Dendritic shafts</i></td><td>415/35,9</td><td>521/45</td><td>936/80,9</td></tr><tr><td><i>Axon terminals</i></td><td>19/1,6</td><td>7/0,6</td><td>26/2.2</td></tr><tr><td>P12</td></tr><tr><td><i>Dendritic spines</i></td><td>191/10,8</td><td>237/13,4</td><td>428/24,1</td></tr><tr><td><i>Dendritic shafts</i></td><td>698/39,2</td><td>581/32,7</td><td>1279/72,1</td></tr><tr><td><i>Axon terminals</i></td><td>55/3,1</td><td>13/0,7</td><td>68/3,8</td></tr><tr><td>P15</td></tr><tr><td><i>Dendritic spines</i></td><td>588/30,2</td><td>157/8,1</td><td>745/38,3</td></tr><tr><td><i>Dendritic shafts</i></td><td>541/27,9</td><td>434/22,3</td><td>975/50,1</td></tr><tr><td><i>Axon terminals</i></td><td>176/9</td><td>51/2,6</td><td>227/11,7</td></tr><tr><td>P21</td></tr><tr><td><i>Dendritic spines</i></td><td>697/32,3</td><td>213/9,9</td><td>910/42,1</td></tr><tr><td><i>Dendritic shafts</i></td><td>602/27,9</td><td>422/19,6</td><td>1024/47,4</td></tr><tr><td><i>Axon terminals</i></td><td>172/8</td><td>55/2,5</td><td>227/10,5</td></tr><tr><td>P60</td></tr><tr><td><i>Dendritic spines</i></td><td>798/33,4</td><td>241/10,1</td><td>1039/43,4</td></tr><tr><td><i>Dendritic shafts</i></td><td>639/26,7</td><td>415/17,3</td><td>1054/44,1</td></tr><tr><td><i>Axon terminals</i></td><td>232/9,7</td><td>67/2,8</td><td>299/12,5</td></tr></table>
<table><tr><td></td><td>Plasma membrane number / %</td><td>Intracellular number / %</td><td>Total immunogold number / %</td></tr><tr><td>P7</td><td colspan="3"></td></tr><tr><td>Dendritic spines</td><td>88/7,6</td><td>107/9,2</td><td>195/16,9</td></tr><tr><td>Dendritic shafts</td><td>415/35,9</td><td>521/45</td><td>936/80,9</td></tr><tr><td>Axon terminals</td><td>19/1,6</td><td>7/0,6</td><td>26/2.2</td></tr><tr><td>P12</td><td colspan="3"></td></tr><tr><td>Dendritic spines</td><td>191/10,8</td><td>237/13,4</td><td>428/24,1</td></tr><tr><td>Dendritic shafts</td><td>698/39,2</td><td>581/32,7</td><td>1279/72,1</td></tr><tr><td>Axon terminals</td><td>55/3,1</td><td>13/0,7</td><td>68/3,8</td></tr><tr><td>P15</td><td colspan="3"></td></tr><tr><td>Dendritic spines</td><td>588/30,2</td><td>157/8,1</td><td>745/38,3</td></tr><tr><td>Dendritic shafts</td><td>541/27,9</td><td>434/22,3</td><td>975/50,1</td></tr><tr><td>Axon terminals</td><td>176/9</td><td>51/2,6</td><td>227/11,7</td></tr><tr><td>P21</td><td colspan="3"></td></tr></table>
<table><tr><td></td><td>Plasma membrane number / %</td><td>Intracellular number / %</td><td>Total immunogold number / %</td></tr><tr><td>Dendritic spines</td><td>697/32,3</td><td>213/9,9</td><td>910/42,1</td></tr><tr><td>Dendritic shafts</td><td>602/27,9</td><td>422/19,6</td><td>1024/47,4</td></tr><tr><td>Axon terminals</td><td>172/8</td><td>55/2,5</td><td>227/10,5</td></tr><tr><td>P60</td><td colspan="3"></td></tr><tr><td>Dendritic spines</td><td>798/33,4</td><td>241/10,1</td><td>1039/43,4</td></tr><tr><td>Dendritic shafts</td><td>639/26,7</td><td>415/17,3</td><td>1054/44,1</td></tr><tr><td>Axon terminals</td><td>232/9,7</td><td>67/2,8</td><td>299/12,5</td></tr></table>
7e23d3b54b3c92f98d1bebac38e16fb42a561e247f2ffc0a1477785387ba249e.png
simple
<table><tr><td>Characteristics</td><td>% (SE)</td></tr><tr><td>Age, y<sup>b</sup></td><td>45.2 &#177; 0.2</td></tr><tr><td> &lt; 65</td><td>86.2 (0.6)</td></tr><tr><td> &#8805; 65</td><td>13.8 (0.6)</td></tr><tr><td>Sex</td><td> </td></tr><tr><td> Male</td><td>49.5 (0.5)</td></tr><tr><td> Female</td><td>50.5 (0.5)</td></tr><tr><td>BMI, kg/m<sup>2</sup></td><td> </td></tr><tr><td> &lt; 25</td><td>68.9 (0.9)</td></tr><tr><td> &#8805; 25</td><td>31.1 (0.9)</td></tr><tr><td>Smoking exposure</td><td> </td></tr><tr><td> Never</td><td>74.3 (0.7)</td></tr><tr><td> Former or current</td><td>25.7 (0.7)</td></tr><tr><td>Alcohol drinking, g/day</td><td> </td></tr><tr><td> &lt; 30</td><td>90.1 (0.6)</td></tr><tr><td> &#8805; 30</td><td>9.9 (0.6)</td></tr><tr><td>Residence area</td><td> </td></tr><tr><td> Rural</td><td>20.2 (1.8)</td></tr><tr><td> Urban</td><td>79.8 (1.8)</td></tr><tr><td>Education</td><td> </td></tr><tr><td> &#8804; High school</td><td>70.4 (1.0)</td></tr><tr><td> &#8805; College</td><td>29.6 (1.0)</td></tr><tr><td>Occupation</td><td> </td></tr><tr><td> Agriculture &amp; fishery</td><td>5.6 (0.6)</td></tr><tr><td> Industry</td><td>9.2 (0.5)</td></tr><tr><td> Services</td><td>85.3 (0.8)</td></tr><tr><td>GFR, ml/min/1.73 m<sup>2b</sup></td><td>95.1 &#177; 0.5</td></tr><tr><td>Blood pressure<sup>b</sup></td><td> </td></tr><tr><td> SBP, mmHg</td><td>116.9 &#177; 0.4</td></tr><tr><td> DBP, mmHg</td><td>76.7 &#177; 0.3</td></tr><tr><td> MAP, mmHg</td><td>88.7 &#177; 0.2</td></tr></table>
<table><tr><td>Characteristics</td><td>% (SE)</td></tr><tr><td>Age, yb</td><td>45.2 ± 0.2</td></tr><tr><td>< 65</td><td>86.2 (0.6)</td></tr><tr><td>≥ 65</td><td>13.8 (0.6)</td></tr><tr><td>Sex</td><td></td></tr><tr><td>Male</td><td>49.5 (0.5)</td></tr><tr><td>Female</td><td>50.5 (0.5)</td></tr><tr><td>BMI, kg/m2</td><td></td></tr><tr><td>< 25</td><td>68.9 (0.9)</td></tr></table>
<table><tr><td>≥ 25</td><td>31.1 (0.9)</td></tr><tr><td>Smoking exposure</td><td></td></tr><tr><td>Never</td><td>74.3 (0.7)</td></tr><tr><td>Former or current</td><td>25.7 (0.7)</td></tr><tr><td>Alcohol drinking, g/day</td><td></td></tr><tr><td>< 30</td><td>90.1 (0.6)</td></tr><tr><td>≥ 30</td><td>9.9 (0.6)</td></tr><tr><td>Residence area</td><td></td></tr><tr><td>Rural</td><td>20.2 (1.8)</td></tr><tr><td>Urban</td><td>79.8 (1.8)</td></tr><tr><td>Education</td><td></td></tr><tr><td>≤ High school</td><td>70.4 (1.0)</td></tr><tr><td>≥ College</td><td>29.6 (1.0)</td></tr><tr><td>Occupation</td><td></td></tr><tr><td>Agriculture & fishery</td><td>5.6 (0.6)</td></tr><tr><td>Industry</td><td>9.2 (0.5)</td></tr><tr><td>Services</td><td>85.3 (0.8)</td></tr><tr><td>GFR, ml/min/1.73 m2b</td><td>95.1 ± 0.5</td></tr><tr><td>Blood pressureb</td><td></td></tr><tr><td>SBP, mmHg</td><td>116.9 ± 0.4</td></tr><tr><td>DBP, mmHg</td><td>76.7 ± 0.3</td></tr><tr><td>MAP, mmHg</td><td>88.7 ± 0.2</td></tr></table>
cb42feb568ca5b0f7eca59fd9ca90eb74143bba53617a721cf321750196361dc.png
simple
<table><tr><td>Comparison</td><td>Keyword</td><td>Gene Set</td><td>Gene Set Description</td><td>Size</td><td>p-valueExp. 2</td><td>Significant Genes</td><td>p-valueExp. 1</td></tr><tr><td>Control vs ALC-NTO/ALC-NTC (see legends)</td><td>Growth,Growth Regulation*</td><td><i>GO:0016049</i>GO:0040007</td><td><i>^Cell growth</i>^Growth</td><td>4775</td><td>0.0020.005</td><td><i>(Ctgf, Igfbp2, Emp1, Osm, Cyr61, Gap43, Crim1, Tgfb3, Igfbp7, Nov, Emp3), Gpc3, Csf1, Socs2, Bmp6, Bmp4, Inhbb, Lepre1, Wrn, Wig1, Cish</i></td><td><i>0.010</i>0.010</td></tr><tr><td></td><td></td><td><i>GO:0001558</i>GO:0040008</td><td><i>Regulation of cell growth</i>Regulation of growth</td><td>3956</td><td>0.0020.016</td><td>(<i>Ctgf, Igfbp2, Osm, Cyr61, Gap43, Crim1, Igfbp7, Nov), Gpc3, Csf1, Socs2</i>,</td><td>0.0060.017</td></tr><tr><td></td><td></td><td>GO:0005520</td><td>Insulin-like growth factor binding</td><td>14</td><td>0.000</td><td><i>Ctgf, Igfbp2, Cyr61, Crim1, Igfbp7, Nov</i></td><td>0.012</td></tr><tr><td></td><td>Heart*</td><td>GO:0001525</td><td>Angiogenesis</td><td>53</td><td>0.022</td><td><i>Ctgf, Anxa2, Cyr61, Thbs1, Vegfa, Tie1, Elk3, Flt1, Crhr2, Vegfc, Kdr, Bmp4, Adra2b, Tnfrsf12a</i></td><td>0.022</td></tr><tr><td></td><td>Eye#</td><td>GO:0001654</td><td>Eye Development</td><td>26</td><td>0.040</td><td><i>Mab21l1, Neurod1, Neurod4, Ntrk2, Fkbp8, Bmpr1b, Crb1, Stat3, Tspan5, Pax6, Bmp4, Map3k1</i></td><td>0.004</td></tr><tr><td></td><td>Epigenetic factor~,^</td><td>GO:0006334</td><td>Nucleosome modeling</td><td>30</td><td>0.021</td><td><i>Hist3h2b, a; Hist1h3f; Hist1h1c; Hist1h2b, c; Hist1h3a; H1f0; Smarca2; Nap1l3</i></td><td>0.033</td></tr><tr><td><i>ALC-NTO vs ALC-NTC</i></td><td>Growth, Growth retardation</td><td>GO:0007173</td><td>Epidermal growth factor receptor (EGFR) signaling pathway</td><td>5</td><td>0.019</td><td><i>Pde6g, Egfr, Hbegf</i>(Enriched in ALC-NTC)</td><td>0.023</td></tr></table>
<table><tr><td>Comparison</td><td>Keyword</td><td>Gene Set</td><td>Gene Set Description</td><td>Size</td><td>p-valueExp. 2</td><td>Significant Genes</td><td>p-valueExp. 1</td></tr></table>
<table><tr><td>Control vs ALC-NTO/ALC-NTC (see legends)</td><td>Growth,Growth Regulation*</td><td>GO:0016049GO:0040007</td><td>^Cell growth^Growth</td><td>4775</td><td>0.0020.005</td><td>(Ctgf, Igfbp2, Emp1, Osm, Cyr61, Gap43, Crim1, Tgfb3, Igfbp7, Nov, Emp3), Gpc3, Csf1, Socs2, Bmp6, Bmp4, Inhbb, Lepre1, Wrn, Wig1, Cish</td><td>0.0100.010</td></tr><tr><td></td><td></td><td>GO:0001558GO:0040008</td><td>Regulation of cell growthRegulation of growth</td><td>3956</td><td>0.0020.016</td><td>(Ctgf, Igfbp2, Osm, Cyr61, Gap43, Crim1, Igfbp7, Nov), Gpc3, Csf1, Socs2,</td><td>0.0060.017</td></tr><tr><td></td><td></td><td>GO:0005520</td><td>Insulin-like growth factor binding</td><td>14</td><td>0.000</td><td>Ctgf, Igfbp2, Cyr61, Crim1, Igfbp7, Nov</td><td>0.012</td></tr><tr><td></td><td>Heart*</td><td>GO:0001525</td><td>Angiogenesis</td><td>53</td><td>0.022</td><td>Ctgf, Anxa2, Cyr61, Thbs1, Vegfa, Tie1, Elk3, Flt1, Crhr2, Vegfc, Kdr, Bmp4, Adra2b, Tnfrsf12a</td><td>0.022</td></tr><tr><td></td><td>Eye#</td><td>GO:0001654</td><td>Eye Development</td><td>26</td><td>0.040</td><td>Mab21l1, Neurod1, Neurod4, Ntrk2, Fkbp8, Bmpr1b, Crb1, Stat3, Tspan5, Pax6, Bmp4, Map3k1</td><td>0.004</td></tr><tr><td></td><td>Epigenetic factor~,^</td><td>GO:0006334</td><td>Nucleosome modeling</td><td>30</td><td>0.021</td><td>Hist3h2b, a; Hist1h3f; Hist1h1c; Hist1h2b, c; Hist1h3a; H1f0; Smarca2; Nap1l3</td><td>0.033</td></tr><tr><td>ALC-NTO vs ALC-NTC</td><td>Growth, Growth retardation</td><td>GO:0007173</td><td>Epidermal growth factor receptor (EGFR) signaling pathway</td><td>5</td><td>0.019</td><td>Pde6g, Egfr, Hbegf(Enriched in ALC-NTC)</td><td>0.023</td></tr></table>
4d73c2d2b00e5ca864625448a3be5eb728c822e7d31fee8db8ab163b6dbe175a.png
complex
<table><tr><td>Criterion</td><td>Response</td><td>No.</td><td>Mean &#177; SD</td><td><i>p</i>-Value</td></tr><tr><td colspan="5">Occupational exposure (mean &#177; SD)</td></tr><tr><td> Yes</td><td>Bone Pb</td><td>108</td><td>14.4 &#177; 0.50<i><sup>a</sup></i></td><td>&lt; 0.001</td></tr><tr><td> No</td><td></td><td>99</td><td>3.22 &#177; 0.50<i><sup>a</sup></i></td><td></td></tr><tr><td> Yes</td><td>Blood Pb</td><td>107</td><td>2.73 &#177; 2.39</td><td>&lt; 0.001</td></tr><tr><td> No</td><td></td><td>98</td><td>1.25 &#177; 2.10</td><td></td></tr><tr><td colspan="5">Smoked ever/never</td></tr><tr><td> Yes</td><td>Bone Pb: exposed</td><td>65</td><td>18.1 &#177; 0.61<i><sup>a</sup></i></td><td>0.002</td></tr><tr><td> No</td><td></td><td>43</td><td>6.87 &#177; 0.86<i><sup>a</sup></i></td><td></td></tr><tr><td> Yes</td><td>Blood Pb: exposed</td><td>64</td><td>3.67 &#177; 12.0</td><td>&lt; 0.001</td></tr><tr><td> No</td><td></td><td>43</td><td>1.76 &#177; 2.49</td><td></td></tr><tr><td colspan="5">Ever used estrogen</td></tr><tr><td> Yes</td><td>Bone Pb: referent</td><td>29</td><td>7.73 &#177; 0.94<i><sup>a</sup></i></td><td>0.003</td></tr><tr><td> No</td><td></td><td>70</td><td>1.41 &#177; 0.60<i><sup>a</sup></i></td><td></td></tr><tr><td> Yes</td><td>Blood Pb: referent</td><td>28</td><td>1.56 &#177; 2.21</td><td>0.038</td></tr><tr><td> No</td><td></td><td>70</td><td>1.15 &#177; 2.03</td><td></td></tr><tr><td colspan="5">Still have menstrual periods</td></tr><tr><td> Yes</td><td>Blood Pb: referent</td><td>59</td><td>1.04 &#177; 1.97</td><td>0.002</td></tr><tr><td> No</td><td></td><td>39</td><td>1.65 &#177; 2.14</td><td></td></tr><tr><td> Yes</td><td>Blood Pb: exposed</td><td>46</td><td>2.09 &#177; 2.49</td><td>0.012</td></tr><tr><td> No</td><td></td><td>61</td><td>3.33 &#177; 2.19</td><td></td></tr><tr><td colspan="5">Surgical menopause</td></tr><tr><td> Yes</td><td>Blood Pb: exposed</td><td>47</td><td>2.87 &#177; 2.12</td><td>0.008</td></tr><tr><td> No</td><td></td><td>14</td><td>5.46 &#177; 2.02</td><td></td></tr><tr><td colspan="5">Postmenopausal women who have used estrogen</td></tr><tr><td> Yes</td><td>Bone Pb: referent</td><td>24</td><td>9.18 &#177; 1.08<i><sup>a</sup></i></td><td>0.007</td></tr><tr><td> No</td><td></td><td>16</td><td>1.83 &#177; 1.32<i><sup>a</sup></i></td><td></td></tr><tr><td colspan="5">Ever used oral contraceptives</td></tr><tr><td> Yes</td><td>Bone Pb: referent</td><td>73</td><td>1.39 &#177; 0.61<i><sup>a</sup></i></td><td>0.036</td></tr><tr><td> No</td><td></td><td>26</td><td>7.22 &#177; 0.90<i><sup>a</sup></i></td><td></td></tr><tr><td> Yes</td><td>Blood Pb: referent</td><td>72</td><td>1.13 &#177; 2.00</td><td>0.006</td></tr><tr><td> No</td><td></td><td>26</td><td>1.66 &#177; 2.66</td><td></td></tr></table>
<table><tr><td>Criterion</td><td>Response</td></tr><tr><td colspan="2">Occupational exposure (mean ± SD)</td></tr><tr><td>Yes</td><td>Bone Pb</td></tr><tr><td>No</td><td></td></tr><tr><td>Yes</td><td>Blood Pb</td></tr><tr><td>No</td><td></td></tr><tr><td colspan="2">Smoked ever/never</td></tr><tr><td>Yes</td><td>Bone Pb: exposed</td></tr><tr><td>No</td><td></td></tr><tr><td>Yes</td><td>Blood Pb: exposed</td></tr><tr><td>No</td><td></td></tr><tr><td colspan="2">Ever used estrogen</td></tr><tr><td>Yes</td><td>Bone Pb: referent</td></tr><tr><td>No</td><td></td></tr><tr><td>Yes</td><td>Blood Pb: referent</td></tr><tr><td>No</td><td></td></tr><tr><td colspan="2">Still have menstrual periods</td></tr><tr><td>Yes</td><td>Blood Pb: referent</td></tr><tr><td>No</td><td></td></tr><tr><td>Yes</td><td>Blood Pb: exposed</td></tr><tr><td>No</td><td></td></tr><tr><td colspan="2">Surgical menopause</td></tr><tr><td>Yes</td><td>Blood Pb: exposed</td></tr><tr><td>No</td><td></td></tr><tr><td colspan="2">Postmenopausal women who have used estrogen</td></tr><tr><td>Yes</td><td>Bone Pb: referent</td></tr><tr><td>No</td><td></td></tr><tr><td colspan="2">Ever used oral contraceptives</td></tr><tr><td>Yes</td><td>Bone Pb: referent</td></tr><tr><td>No</td><td></td></tr><tr><td>Yes</td><td>Blood Pb: referent</td></tr><tr><td>No</td><td></td></tr></table>
<table><tr><td>No.</td><td>Mean ± SD</td><td>p-Value</td></tr><tr><td colspan="3">Occupational exposure (mean ± SD)</td></tr><tr><td>108</td><td>14.4 ± 0.50a</td><td>< 0.001</td></tr><tr><td>99</td><td>3.22 ± 0.50a</td><td></td></tr><tr><td>107</td><td>2.73 ± 2.39</td><td>< 0.001</td></tr><tr><td>98</td><td>1.25 ± 2.10</td><td></td></tr><tr><td colspan="3">Smoked ever/never</td></tr><tr><td>65</td><td>18.1 ± 0.61a</td><td>0.002</td></tr><tr><td>43</td><td>6.87 ± 0.86a</td><td></td></tr><tr><td>64</td><td>3.67 ± 12.0</td><td>< 0.001</td></tr><tr><td>43</td><td>1.76 ± 2.49</td><td></td></tr><tr><td colspan="3">Ever used estrogen</td></tr><tr><td>29</td><td>7.73 ± 0.94a</td><td>0.003</td></tr><tr><td>70</td><td>1.41 ± 0.60a</td><td></td></tr><tr><td>28</td><td>1.56 ± 2.21</td><td>0.038</td></tr><tr><td>70</td><td>1.15 ± 2.03</td><td></td></tr><tr><td colspan="3">Still have menstrual periods</td></tr><tr><td>59</td><td>1.04 ± 1.97</td><td>0.002</td></tr><tr><td>39</td><td>1.65 ± 2.14</td><td></td></tr><tr><td>46</td><td>2.09 ± 2.49</td><td>0.012</td></tr><tr><td>61</td><td>3.33 ± 2.19</td><td></td></tr><tr><td colspan="3">Surgical menopause</td></tr><tr><td>47</td><td>2.87 ± 2.12</td><td>0.008</td></tr><tr><td>14</td><td>5.46 ± 2.02</td><td></td></tr><tr><td colspan="3">Postmenopausal women who have used estrogen</td></tr><tr><td>24</td><td>9.18 ± 1.08a</td><td>0.007</td></tr><tr><td>16</td><td>1.83 ± 1.32a</td><td></td></tr><tr><td colspan="3">Ever used oral contraceptives</td></tr><tr><td>73</td><td>1.39 ± 0.61a</td><td>0.036</td></tr><tr><td>26</td><td>7.22 ± 0.90a</td><td></td></tr><tr><td>72</td><td>1.13 ± 2.00</td><td>0.006</td></tr><tr><td>26</td><td>1.66 ± 2.66</td><td></td></tr></table>
21055bf85d4d94418504e2d72d8836994ea66d62b922b2a22e8f9a1a8bde0037.png
simple
<table><tr><td>Parameter</td><td>(n = 504)</td></tr><tr><td>Age (Years)</td><td></td></tr><tr><td> &lt;50 Years</td><td>422 (84)</td></tr><tr><td> &gt;50 Years</td><td>82(16)</td></tr><tr><td>Sex</td><td></td></tr><tr><td> Male</td><td>423(84)</td></tr><tr><td> Female</td><td>82(16)</td></tr><tr><td>Pre existing comorbid conditions</td><td></td></tr><tr><td> Respiratory disease</td><td>51 (10)</td></tr><tr><td> Renal Disease</td><td>27 (50)</td></tr><tr><td> Malignancy</td><td>25 (5)</td></tr><tr><td> Hypertension</td><td>11 92)</td></tr><tr><td> Diabetes mellitus</td><td>5 (1)</td></tr><tr><td>Signs and symptoms</td><td></td></tr><tr><td> Pain</td><td>495 (98)</td></tr><tr><td> Vomiting</td><td>296 (59)</td></tr><tr><td> Abdominal distention</td><td>221 (44)</td></tr><tr><td> Constipation</td><td>193 (38)</td></tr><tr><td> Fever</td><td>124 (25)</td></tr><tr><td> Diarrhoea</td><td>35 (7)</td></tr><tr><td> Tachycardia (pulse &gt;/110/minute)</td><td>115 (23)</td></tr><tr><td> Hypotention (Systolic blood pressure &lt;100 mm Hg)</td><td>44 (9)</td></tr><tr><td> Urine output (&lt;30 ml/hr)</td><td>80 (16)</td></tr><tr><td> Tacchypnea (respiratory rate &gt;20/minute)</td><td>334 (66)</td></tr><tr><td>Investigations</td><td></td></tr><tr><td> Pneumoperitoneum on Chest X-Ray</td><td>340(67)</td></tr><tr><td> Air fluid levels on abdominal X-Ray</td><td>108(21)</td></tr><tr><td> Hyponatraemia(Na&lt;130 mEq/L)</td><td>148(29)</td></tr><tr><td> Hypokalemia(K&lt;2.7 mEq/L)</td><td>44(09)</td></tr><tr><td> Blood Urea Nitrogen(&gt;167 mg/dl)</td><td>76(15)</td></tr><tr><td> Serum Creatinine(&lt;1.7 mg/dl)</td><td>65(13)</td></tr></table>
<table><tr><td>Parameter</td><td>(n = 504)</td></tr><tr><td>Age (Years)</td><td></td></tr><tr><td><50 Years</td><td>422 (84)</td></tr><tr><td>>50 Years</td><td>82(16)</td></tr><tr><td>Sex</td><td></td></tr><tr><td>Male</td><td>423(84)</td></tr><tr><td>Female</td><td>82(16)</td></tr><tr><td>Pre existing comorbid conditions</td><td></td></tr><tr><td>R</td><td>51 (10)</td></tr></table>
<table><tr><td>Parameter</td><td>(n = 504)</td></tr><tr><td>espiratory disease</td><td></td></tr><tr><td>Renal Disease</td><td>27 (50)</td></tr><tr><td>Malignancy</td><td>25 (5)</td></tr><tr><td>Hypertension</td><td>11 92)</td></tr><tr><td>Diabetes mellitus</td><td>5 (1)</td></tr><tr><td>Signs and symptoms</td><td></td></tr><tr><td>Pain</td><td>495 (98)</td></tr><tr><td>Vomiting</td><td>296 (59)</td></tr><tr><td>Abdominal distention</td><td>221 (44)</td></tr><tr><td>Constipation</td><td>193 (38)</td></tr><tr><td>Fever</td><td>124 (25)</td></tr><tr><td>Diarrhoea</td><td>35 (7)</td></tr><tr><td>Tachycardia (pulse >/110/minute)</td><td>115 (23)</td></tr><tr><td>Hypotention (Systolic blood pressure <100 mm Hg)</td><td>44 (9)</td></tr><tr><td>Urine output (<30 ml/hr)</td><td>80 (16)</td></tr><tr><td>Tacchypnea (respiratory rate >20/minute)</td><td>334 (66)</td></tr><tr><td>Investigations</td><td></td></tr><tr><td>Pneumoperitoneum on Chest X-Ray</td><td>340(67)</td></tr><tr><td>Air fluid levels on abdominal X-Ray</td><td>108(21)</td></tr><tr><td>Hyponatraemia(Na<130 mEq/L)</td><td>148(29)</td></tr><tr><td>Hypokalemia(K<2.7 mEq/L)</td><td>44(09)</td></tr><tr><td>Blood Urea Nitrogen(>167 mg/dl)</td><td>76(15)</td></tr><tr><td>Serum Creatinine(<1.7 mg/dl)</td><td>65(13)</td></tr></table>
88a6102a2c1293122652729fa3d016433b71ac73d042de34b08260ab0ad9b992.png
simple
<table><tr><td>Group</td><td><i>n</i></td><td>Before therapy</td><td>After therapy</td></tr><tr><td>Met + Acu Group</td><td>49</td><td>5.57 &#177; 0.257</td><td>3.23 &#177; 0.170<sup>***</sup><sup>&#9651;&#9651;</sup></td></tr><tr><td>Control Group</td><td>49</td><td>5.50 &#177; 0.244</td><td>4.25 &#177; 0.197<sup>***</sup></td></tr></table>
<table><tr><td>Group</td><td>n</td><td>Before therapy</td><td>After therapy</td></tr></table>
<table><tr><td>Met + Acu Group</td><td>49</td><td>5.57 ± 0.257</td><td>3.23 ± 0.170***△△</td></tr><tr><td>Control Group</td><td>49</td><td>5.50 ± 0.244</td><td>4.25 ± 0.197***</td></tr></table>
1695a2c37ec9b6df3ec7321b91cfbdb8c10728154639901259fa9de0b363596a.png
complex
<table><tr><td>Practice related variables</td><td>Percentage (%)</td></tr><tr><td colspan="2">Monitor blood glucose</td></tr><tr><td> Daily</td><td>10 (8)</td></tr><tr><td> Weekly</td><td>18 (15)</td></tr><tr><td> Monthly</td><td>45 (37)</td></tr><tr><td> Never</td><td>49 (40)</td></tr><tr><td colspan="2">Blood pressure monitor</td></tr><tr><td> Daily</td><td>12 (10)</td></tr><tr><td> Weekly</td><td>4 (3)</td></tr><tr><td> Monthly</td><td>49 (40)</td></tr><tr><td> Never</td><td>57 (47)</td></tr><tr><td colspan="2">Adherence to medication</td></tr><tr><td> Regular</td><td>53 (43)</td></tr><tr><td> Irregular</td><td>69 (57)</td></tr><tr><td>Visiting an eye specialist</td><td></td></tr><tr><td> Every 6&#8211;12 months</td><td>13 (11)</td></tr><tr><td> Every year</td><td>45 (37)</td></tr><tr><td> Felt problem with vision</td><td>64 (52)</td></tr></table>
<table><tr><td>Practice related variables</td><td>Percentage (%)</td></tr></table>
<table><tr><td colspan="2">Monitor blood glucose</td></tr><tr><td>Daily</td><td>10 (8)</td></tr><tr><td>Weekly</td><td>18 (15)</td></tr><tr><td>Monthly</td><td>45 (37)</td></tr><tr><td>Never</td><td>49 (40)</td></tr><tr><td colspan="2">Blood pressure monitor</td></tr><tr><td>Daily</td><td>12 (10)</td></tr><tr><td>Weekly</td><td>4 (3)</td></tr><tr><td>Monthly</td><td>49 (40)</td></tr><tr><td>Never</td><td>57 (47)</td></tr><tr><td colspan="2">Adherence to medication</td></tr><tr><td>Regular</td><td>53 (43)</td></tr><tr><td>Irregular</td><td>69 (57)</td></tr><tr><td>Visiting an eye specialist</td><td></td></tr><tr><td>Every 6–12 months</td><td>13 (11)</td></tr><tr><td>Every year</td><td>45 (37)</td></tr><tr><td>Felt problem with vision</td><td>64 (52)</td></tr></table>
c913ab6b8aee1ac196cb0061bc8c3057c04728ec7558f5474f96abf10e88dfd5.png
complex
<table><tr><td>Species</td><td>Population</td><td>Hostplant</td><td colspan="2">Coordinates</td></tr><tr><td><i>T</i>. <i>bartmani</i></td><td>JL</td><td><i>Abies concolor</i></td><td>34.170000</td><td>-117.002017</td></tr><tr><td><i>T</i>. <i>bartmani</i></td><td>RS</td><td><i>Abies concolor</i></td><td>34.210000</td><td>-117.098333</td></tr><tr><td><i>T</i>. <i>boharti</i></td><td>ML</td><td><i>Adenostoma</i></td><td>32.881200</td><td>-116.445917</td></tr><tr><td><i>T</i>. <i>californicum</i></td><td>Fremont</td><td><i>Adenostoma</i></td><td>36.763517</td><td>-121.502533</td></tr><tr><td><i>T</i>. <i>californicum</i></td><td>HW1</td><td><i>Quercus</i></td><td>36.286933</td><td>-121.841883</td></tr><tr><td><i>T</i>. <i>chumash</i></td><td>HW2</td><td><i>Adenostoma</i></td><td>34.269700</td><td>-118.168483</td></tr><tr><td><i>T</i>. <i>chumash</i></td><td>ED</td><td><i>Ceanothus</i></td><td>33.885183</td><td>-116.859783</td></tr><tr><td><i>T</i>. <i>cristinae</i></td><td>WTA</td><td><i>Adenostoma</i></td><td>34.515833</td><td>-120.073150</td></tr><tr><td><i>T</i>. <i>cristinae</i></td><td>OJ</td><td><i>Ceanothus</i></td><td>34.485300</td><td>-119.298117</td></tr><tr><td><i>T</i>. <i>knulli</i></td><td>Trail</td><td><i>Sequoia</i></td><td>35.836200</td><td>-121.391483</td></tr><tr><td><i>T</i>. <i>knulli</i></td><td>BC</td><td><i>Ceanothus</i></td><td>36.071017</td><td>-121.595567</td></tr><tr><td><i>T</i>. <i>petita</i></td><td>Ma</td><td><i>Ceanothus</i></td><td>36.358900</td><td>-121.900350</td></tr><tr><td><i>T</i>. <i>petita</i></td><td>Mo</td><td><i>Ceanothus</i></td><td>36.476533</td><td>-121.936133</td></tr><tr><td><i>T</i>. <i>podura</i></td><td>HW243</td><td><i>Adenostoma</i></td><td>33.815117</td><td>-116.791033</td></tr><tr><td><i>T</i>. <i>podura</i></td><td>Seq</td><td><i>Ceanothus</i></td><td>35.583333</td><td>-118.533333</td></tr><tr><td><i>T</i>. <i>poppensis</i></td><td>Fish</td><td><i>Pseudotsuga</i></td><td>38.885283</td><td>-123.517150</td></tr><tr><td><i>T</i>. <i>poppensis</i></td><td>Mado</td><td><i>Sequoia</i></td><td>36.996433</td><td>-121.717783</td></tr><tr><td><i>T</i>. <i>cristinae</i></td><td>OGA</td><td><i>Adenostoma</i></td><td>33.990567</td><td>-116.061417</td></tr><tr><td><i>T</i>. <i>cristinae</i></td><td>R23A</td><td><i>Adenostoma</i></td><td>34.519067</td><td>-120.077500</td></tr><tr><td><i>T</i>. <i>cristinae</i></td><td>SC</td><td><i>Ceanothus</i></td><td>34.522300</td><td>-119.831283</td></tr><tr><td><i>T</i>. <i>cristinae</i></td><td>PEC</td><td><i>Ceanothus</i></td><td>34.491333</td><td>-119.795017</td></tr></table>
<table><tr><td>Species</td><td>Population</td><td>Hostplant</td><td colspan="2">Coordinates</td></tr><tr><td>T. bartmani</td><td>JL</td><td>Abies concolor</td><td>34.170000</td><td>-117.002017</td></tr><tr><td>T. bartmani</td><td>RS</td><td>Abies concolor</td><td>34.210000</td><td>-117.098333</td></tr><tr><td>T. boharti</td><td>ML</td><td>Adenostoma</td><td>32.881200</td><td>-116.445917</td></tr><tr><td>T. californicum</td><td>Fremont</td><td>Adenostoma</td><td>36.763517</td><td>-121.502533</td></tr><tr><td>T. californicum</td><td>HW1</td><td>Quercus</td><td>36.286933</td><td>-121.841883</td></tr><tr><td>T. chumash</td><td>HW2</td><td>Adenostoma</td><td>34.269700</td><td>-118.168483</td></tr><tr><td>T. chumash</td><td>ED</td><td>Ceanothus</td><td>33.885183</td><td>-116.859783</td></tr><tr><td>T. cristinae</td><td>WTA</td><td>Adenostoma</td><td>34.515833</td><td>-120.073150</td></tr><tr><td>T. cristinae</td><td>OJ</td><td>Ceanothus</td><td>34.485300</td><td>-119.298117</td></tr><tr><td>T. knulli</td><td>Trail</td><td>Sequoia</td><td>35.836200</td><td>-121.391483</td></tr><tr><td>T. knulli</td><td>BC</td><td>Ceanothus</td><td>36.071017</td><td>-121.595567</td></tr><tr><td>T. pe</td><td>M</td><td>Cean</td><td>36.3</td><td>-12</td></tr></table>
<table><tr><td>tita</td><td>a</td><td>othus</td><td>58900</td><td>1.900350</td></tr><tr><td>T. petita</td><td>Mo</td><td>Ceanothus</td><td>36.476533</td><td>-121.936133</td></tr><tr><td>T. podura</td><td>HW243</td><td>Adenostoma</td><td>33.815117</td><td>-116.791033</td></tr><tr><td>T. podura</td><td>Seq</td><td>Ceanothus</td><td>35.583333</td><td>-118.533333</td></tr><tr><td>T. poppensis</td><td>Fish</td><td>Pseudotsuga</td><td>38.885283</td><td>-123.517150</td></tr><tr><td>T. poppensis</td><td>Mado</td><td>Sequoia</td><td>36.996433</td><td>-121.717783</td></tr><tr><td>T. cristinae</td><td>OGA</td><td>Adenostoma</td><td>33.990567</td><td>-116.061417</td></tr><tr><td>T. cristinae</td><td>R23A</td><td>Adenostoma</td><td>34.519067</td><td>-120.077500</td></tr><tr><td>T. cristinae</td><td>SC</td><td>Ceanothus</td><td>34.522300</td><td>-119.831283</td></tr><tr><td>T. cristinae</td><td>PEC</td><td>Ceanothus</td><td>34.491333</td><td>-119.795017</td></tr></table>
860f6b755e8311104a8bb2df4289980a33abcf6752f2a0ba71930425bebca077.png
complex
<table><tr><td rowspan="3">Phenotype</td><td colspan="5">Life-history Classification</td></tr><tr><td colspan="2">Resident Rainbow (RR)</td><td colspan="2">Steelhead Smolt (SS)</td><td><i>P</i></td></tr><tr><td>Mean</td><td>SE</td><td>Mean</td><td>SE</td><td>H<sub>0</sub>: &#956;<sub>RR</sub> = &#956;<sub>SS</sub></td></tr><tr><td>Length605</td><td>94.90909</td><td>1.59297</td><td>95.25000</td><td>0.81523</td><td>0.849</td></tr><tr><td>Length905</td><td>193.47727</td><td>2.48981</td><td>191.07143</td><td>1.27420</td><td>0.391</td></tr><tr><td>Lenght606</td><td>218.77273</td><td>3.08109</td><td>232.58333</td><td>1.57680</td><td>&lt;0.0001</td></tr><tr><td>Weight605</td><td>9.72290</td><td>0.55520</td><td>10.04140</td><td>0.26860</td><td>0.618</td></tr><tr><td>Weight905</td><td>106.12000</td><td>4.26820</td><td>92.40100</td><td>2.06510</td><td>0.006</td></tr><tr><td>Weight606</td><td>137.09091</td><td>6.11324</td><td>139.24941</td><td>3.12855</td><td>0.754</td></tr><tr><td>Kfact605</td><td>1.14757</td><td>0.01643</td><td>1.11501</td><td>0.00841</td><td>0.079</td></tr><tr><td>Kfact905</td><td>1.44220</td><td>0.01103</td><td>1.29540</td><td>0.00534</td><td>&lt;0.0001</td></tr><tr><td>Kfact606</td><td>1.25300</td><td>0.01039</td><td>1.08040</td><td>0.00503</td><td>&lt;0.0001</td></tr><tr><td>IGRL1</td><td>0.67905</td><td>0.00876</td><td>0.66566</td><td>0.00448</td><td>0.175</td></tr><tr><td>IGRW1</td><td>2.26189</td><td>0.02634</td><td>2.14185</td><td>0.01348</td><td>&lt;0.0001</td></tr><tr><td>IGRL2</td><td>0.04539</td><td>0.00189</td><td>0.07573</td><td>0.00092</td><td>&lt;0.0001</td></tr><tr><td>IGRW2</td><td>0.08184</td><td>0.00594</td><td>0.15670</td><td>0.00288</td><td>&lt;0.0001</td></tr><tr><td>AvgPix</td><td>25.27810</td><td>2.91850</td><td>72.17890</td><td>0.70010</td><td>&lt;0.0001</td></tr><tr><td>PWL</td><td>10.85140</td><td>0.34410</td><td>3.79260</td><td>0.21880</td><td>&lt;0.0001</td></tr><tr><td>BPNa</td><td>213.32000</td><td>3.15090</td><td>187.58000</td><td>2.00820</td><td>&lt;0.0001</td></tr><tr><td>Centroid_Size</td><td>2111.85000</td><td>49.41540</td><td>2191.30000</td><td>25.94380</td><td>0.156</td></tr><tr><td>RelW2</td><td>0.01278</td><td>0.00104</td><td>-0.01308</td><td>0.00052</td><td>&lt;0.0001</td></tr><tr><td>RelW3</td><td>0.01461</td><td>0.00095</td><td>0.00911</td><td>0.00047</td><td>&lt;0.0001</td></tr><tr><td>RelW4</td><td><i>0.00502</i></td><td><i>0.00117</i></td><td><i>0.00420</i></td><td><i>0.00061</i></td><td><i>0.540</i></td></tr><tr><td>RelW5</td><td>&#8722;0.00131</td><td>0.00124</td><td>0.00054</td><td>0.00065</td><td>0.188</td></tr><tr><td>RelW6</td><td><i>0.00225</i></td><td><i>0.00091</i></td><td><i>0.00353</i></td><td><i>0.00045</i></td><td><i>0.226</i></td></tr><tr><td>RelW7</td><td>0.00239</td><td>0.00079</td><td>0.00279</td><td>0.00041</td><td>0.656</td></tr><tr><td>RelW8</td><td>0.00081</td><td>0.00069</td><td>0.00253</td><td>0.00036</td><td>0.029</td></tr><tr><td>RelW9</td><td><i>0.00142</i></td><td><i>0.00071</i></td><td><i>-0.00007</i></td><td><i>0.00037</i></td><td><i>0.089</i></td></tr><tr><td>RelW10</td><td>&#8722;0.00063</td><td>0.00083</td><td>&#8722;0.00146</td><td>0.00043</td><td>0.374</td></tr></table>
<table><tr><td>Phenotype</td><td colspan="5">Life-history Classification</td></tr></table>
<table><tr><td rowspan="2">Phenotype</td><td colspan="2">Resident Rainbow (RR)</td><td colspan="2">Steelhead Smolt (SS)</td><td>P</td></tr><tr><td>Mean</td><td>SE</td><td>Mean</td><td>SE</td><td>H0: μRR = μSS</td></tr><tr><td>Length605</td><td>94.90909</td><td>1.59297</td><td>95.25000</td><td>0.81523</td><td>0.849</td></tr><tr><td>Length905</td><td>193.47727</td><td>2.48981</td><td>191.07143</td><td>1.27420</td><td>0.391</td></tr><tr><td>Lenght606</td><td>218.77273</td><td>3.08109</td><td>232.58333</td><td>1.57680</td><td><0.0001</td></tr><tr><td>Weight605</td><td>9.72290</td><td>0.55520</td><td>10.04140</td><td>0.26860</td><td>0.618</td></tr><tr><td>Weight905</td><td>106.12000</td><td>4.26820</td><td>92.40100</td><td>2.06510</td><td>0.006</td></tr><tr><td>Weight606</td><td>137.09091</td><td>6.11324</td><td>139.24941</td><td>3.12855</td><td>0.754</td></tr><tr><td>Kfact605</td><td>1.14757</td><td>0.01643</td><td>1.11501</td><td>0.00841</td><td>0.079</td></tr><tr><td>Kfact905</td><td>1.44220</td><td>0.01103</td><td>1.29540</td><td>0.00534</td><td><0.0001</td></tr><tr><td>Kfact606</td><td>1.25300</td><td>0.01039</td><td>1.08040</td><td>0.00503</td><td><0.0001</td></tr><tr><td>IGRL1</td><td>0.67905</td><td>0.00876</td><td>0.66566</td><td>0.00448</td><td>0.175</td></tr><tr><td>IGRW1</td><td>2.26189</td><td>0.02634</td><td>2.14185</td><td>0.01348</td><td><0.0001</td></tr><tr><td>IGRL2</td><td>0.04539</td><td>0.00189</td><td>0.07573</td><td>0.00092</td><td><0.0001</td></tr><tr><td>IGRW2</td><td>0.08184</td><td>0.00594</td><td>0.15670</td><td>0.00288</td><td><0.0001</td></tr><tr><td>AvgPix</td><td>25.27810</td><td>2.91850</td><td>72.17890</td><td>0.70010</td><td><0.0001</td></tr><tr><td>PWL</td><td>10.85140</td><td>0.34410</td><td>3.79260</td><td>0.21880</td><td><0.0001</td></tr><tr><td>BPNa</td><td>213.32000</td><td>3.15090</td><td>187.58000</td><td>2.00820</td><td><0.0001</td></tr><tr><td>Centroid_Size</td><td>2111.85000</td><td>49.41540</td><td>2191.30000</td><td>25.94380</td><td>0.156</td></tr><tr><td>RelW2</td><td>0.01278</td><td>0.00104</td><td>-0.01308</td><td>0.00052</td><td><0.0001</td></tr><tr><td>RelW3</td><td>0.01461</td><td>0.00095</td><td>0.00911</td><td>0.00047</td><td><0.0001</td></tr><tr><td>RelW4</td><td>0.00502</td><td>0.00117</td><td>0.00420</td><td>0.00061</td><td>0.540</td></tr><tr><td>RelW5</td><td>−0.00131</td><td>0.00124</td><td>0.00054</td><td>0.00065</td><td>0.188</td></tr><tr><td>RelW6</td><td>0.00225</td><td>0.00091</td><td>0.00353</td><td>0.00045</td><td>0.226</td></tr><tr><td>RelW7</td><td>0.00239</td><td>0.00079</td><td>0.00279</td><td>0.00041</td><td>0.656</td></tr><tr><td>RelW8</td><td>0.00081</td><td>0.00069</td><td>0.00253</td><td>0.00036</td><td>0.029</td></tr><tr><td>RelW9</td><td>0.00142</td><td>0.00071</td><td>-0.00007</td><td>0.00037</td><td>0.089</td></tr><tr><td>RelW10</td><td>−0.00063</td><td>0.00083</td><td>−0.00146</td><td>0.00043</td><td>0.374</td></tr></table>
04c4bf76e8056bc7603921467c731bd9c6e99a773bacff6ff0e47698e514efce.png
complex
<table><tr><td>Sample</td><td>h-IgA Addition (ng/mL)</td><td>Detection (ng/mL)</td><td>Recovery</td></tr><tr><td rowspan="3">1</td><td>0</td><td>190.83</td><td>---</td></tr><tr><td>25</td><td>214.25</td><td>93.7%</td></tr><tr><td>50</td><td>242.25</td><td>102.8%</td></tr><tr><td rowspan="3">2</td><td>0</td><td>218.83</td><td>---</td></tr><tr><td>25</td><td>242.65</td><td>95.28%</td></tr><tr><td>50</td><td>274.93</td><td>112.2%</td></tr></table>
<table><tr><td>Sample</td><td>h-IgA Addition (ng/mL)</td><td>Detection (ng/mL)</td><td>Recovery</td></tr><tr><td rowspan="3">1</td><td>0</td><td>190.83</td><td>---</td></tr><tr><td>25</td><td>214.25</td><td>93.7%</td></tr><tr><td>50</td><td>242.25</td><td>102.8%</td></tr><tr><td rowspan="2">2</td><td>0</td><td>218.83</td><td>---</td></tr><tr><td>2</td><td>242</td><td></td></tr></table>
<table><tr><td>h-IgA Addition (ng/mL)</td><td>Detection (ng/mL)</td><td>Recovery</td></tr><tr><td>5</td><td>.65</td><td>95.28%</td></tr><tr><td>50</td><td>274.93</td><td>112.2%</td></tr></table>
1b8549e80ab444f2c3770ca7ff5fb814950d3ae2aed2c7f42e73e11e183af607.png
simple
<table><tr><td>PHASE</td><td>ACTIVITY</td><td>PURPOSE</td><td>LOGISTICS</td><td>PARTICIPANTS</td><td>OUTPUTS</td></tr><tr><td>1.Max.5 &#215; 8hourshifts</td><td>Initial unstructuredobservations</td><td>&#8226; Familiarisation with space and use of space&#8226; Familiarisation with rhythm of setting&#8226; Starting to build relationships and trust&#8226; Determine who is amenable to shadowing&#8226; Identify key locations for stationaryobservations&#8226; Identify key policy/guideline documents</td><td>&#8226; Background observation ofactivity (potentiallyaccompanying key initialcontact in the setting)&#8226; Introductions with staffmembers&#8226; 5 shifts on different days ofthe week (over 2 weeks)(= max 40 hours)</td><td>All staff</td><td>&#8226; Map of settings&#8226; Timetable of key regular events&#8226; List of 6-8 key informants&#8226; Collected documents for lateranalysis (e.g. policies, guidelines)&#8226; Fieldnotes</td></tr><tr><td>2.Max.8 &#215; 8hourshifts</td><td>Shadowing staffmembers</td><td>&#8226; Observe mechanics of interactionalconstruction of safe practice&#8226; Observe interactions newcomers/old-timers&#8226; Observe use of tools/artefacts/environment&#8226; Identifying key practices to follow in laterstage</td><td>&#8226; Shadow each staff memberfor 1 shift/part shift&#8226; Audio recording of keymeetings attended by staffmember&#8226; Field notes of informal talk&#8226; Field interviews</td><td>2 doctors2 nurses2 allied health2 managers</td><td>&#8226; Map of practices of each keyinformant - how they construepatient safety and how they goabout trying to maintain it&#8226; Fieldnotes&#8226; Transcriptions of meetings</td></tr><tr><td>3.Max.2 &#215; 8hourshifts</td><td>Stationaryobservations in keylocations</td><td>&#8226; Observe role of key artefacts in constitution ofsafety (e.g. phone in nurse's station; filingcabinet etc).&#8226; Observe patterns of movement of staff</td><td>&#8226; 2 locations, 1 shift each(max. 16 hours)</td><td>All staff</td><td>&#8226; Fieldnote account of how artefactsand space play a role in theconstitution of safety&#8226; Actor-artefact network map</td></tr><tr><td>4.Max.4 &#215; 8hourshifts</td><td>Tracing keypractices</td><td>&#8226; Observe the unfolding of specific practicespreviously identified as key to preservation ofsafety&#8226; Observe differences in activity when practice isin the course of the everyday (e.g. admission/discharge) and, if appropriate, when it followsbreakdown in order (e.g. incident review)</td><td>&#8226; 1 'everyday' practice overthe course of 2 shifts&#8226; 1 practice dealing withdeviation from the normal (i.e.when safe practice hasbroken down in some way)</td><td>Staff involved inpractices chosen</td><td>&#8226; Map of 'practice nets' involved inpractices key to preservation ofsafety&#8226; How practice nets change whensafety breaks down</td></tr><tr><td>5.Approx.1 hr perinterview</td><td>Interviews</td><td>&#8226; Elicit narrative accounts of safety preservation&#8226; Observe how the meaning of safety isconstructed by different professionals - what'rules and resources' do they draw on?&#8226; Test emerging findings/maps of practices</td><td>&#8226; 6-8 interviews - audiorecordings</td><td>6-8 key informantsfrom phase 2</td><td>&#8226; Transcripts for analysis</td></tr><tr><td>6.Approx.30 minspersurvey</td><td>&#8226;Social networksurvey</td><td>&#8226; Provide triangulation of observation andinterview data&#8226; Map overall patterns of communication aboutsafety issues within and between the twosettings under study</td><td>&#8226; Administer a social networkquestionnaire to all staff in theinpatient team andcommunity team under study.</td><td>All staff</td><td>&#8226; Social network diagrams providingvisual representation of patterns ofsafety communication</td></tr></table>
<table><tr><td>PHASE</td><td>ACTIVITY</td><td>PURPOSE</td><td>LOGISTICS</td><td>PARTICIPANTS</td><td>OUTPUTS</td></tr><tr><td>1.Max.5 × 8hourshifts</td><td>Initial unstructuredobservations</td><td>• Familiarisation with space and use of space• Familiarisation with rhythm of setting• Starting to build relationships and trust• Determine who is amenable to shadowing• Identify key locations for stationaryobservations• Identify key policy/guideline documents</td><td>• Background observation ofactivity (potentiallyaccompanying key initialcontact in the setting)• Introductions with staffmembers• 5 shifts on different days ofthe week (over 2 weeks)(= max 40 hours)</td><td>All staff</td><td>• Map of settings• Timetable of key regular events• List of 6-8 key informants• Collected documents for lateranalysis (e.g. policies, guidelines)• Fieldnotes</td></tr><tr><td>2.Max.8 × 8hourshifts</td><td>Shadowing staffmembers</td><td>• Observe mechanics of interactionalconstruction of safe practice• Observe interactions newcomers/old-timers• Observe use of tools/artefacts/environment• Identifying key practices to follow in laterstage</td><td>• Shadow each staff memberfor 1 shift/part shift• Audio recording of keymeetings attended by staffmember• Field notes of informal talk• Field interviews</td><td>2 doctors2 nurses2 allied health2 managers</td><td>• Map of practices of each keyinformant - how they construepatient safety and how they goabout trying to maintain it• Fieldnotes• Transcriptions of meetings</td></tr><tr><td>3.Max.2 × 8hourshifts</td><td>Stationaryobservations in keylocations</td><td>• Observe role of key artefacts in constitution ofsafety (e.g. phone in nurse's station; filingcabinet etc).• Observe patterns of movement of staff</td><td>• 2 locations, 1 shift each(max. 16 hours)</td><td>All staff</td><td>• Fieldnote account of how artefactsand space play a role in theconstitution of safety• Actor-artefact network map</td></tr><tr><td>4.Max.4 × 8hourshifts</td><td>Tracing keypractices</td><td>• Observe the unfolding of specific practicespreviously identified as key to preservation ofsafety• Observe differences in activity when practice isin the course of the everyday (e.g. admission/discharge) and, if appropriate, when it followsbreakdown in order (e.g. incident review)</td><td>• 1 'everyday' practice overthe course of 2 shifts• 1 practice dealing withdeviation from the normal (i.e.when safe practice hasbroken down in some way)</td><td>Staff involved inpractices chosen</td><td>• Map of 'practice nets' involved inpractices key to preservation ofsafety• How practice nets change whensafety breaks down</td></tr><tr><td>5.Approx.1 hr perint</td><td>Intervi</td><td>• Elicit narrative accounts of safety preservation• Observe how the meaning of safety isconstructed by different professionals -</td><td>• 6-8 interviews - audiorecordings</td><td>6-8 key informantsfr</td><td>• Transcripts f</td></tr></table>
<table><tr><td>PHASE</td><td>ACTIVITY</td><td>PURPOSE</td><td>LOGISTICS</td><td>PARTICIPANTS</td><td>OUTPUTS</td></tr><tr><td>erview</td><td>ews</td><td> what'rules and resources' do they draw on?• Test emerging findings/maps of practices</td><td></td><td>om phase 2</td><td>or analysis</td></tr><tr><td>6.Approx.30 minspersurvey</td><td>•Social networksurvey</td><td>• Provide triangulation of observation andinterview data• Map overall patterns of communication aboutsafety issues within and between the twosettings under study</td><td>• Administer a social networkquestionnaire to all staff in theinpatient team andcommunity team under study.</td><td>All staff</td><td>• Social network diagrams providingvisual representation of patterns ofsafety communication</td></tr></table>
a9c90616fb5f5324f02ade9e48d38eeecbd3b9f5f01fc1f0d1a46a5d07515557.png
complex
<table><tr><td>Variables</td><td colspan="2">CU<sup>c</sup> (<i>N</i> = 35)</td><td colspan="2">nCU<sup>d</sup> (<i>N</i> = 48)</td><td><i>t</i></td><td><i>p</i></td></tr><tr><td></td><td>Mean</td><td>SD</td><td>Mean</td><td>SD</td><td></td><td></td></tr><tr><td>Age</td><td>22.51</td><td>5.63</td><td>21.67</td><td>3.56</td><td>0.84</td><td>0.40</td></tr><tr><td>UnEx<sup>a</sup></td><td>7.63</td><td>6.04</td><td>5.44</td><td>3.71</td><td>1.90</td><td>0.06</td></tr><tr><td>CogDis<sup>b</sup></td><td>10.46</td><td>5.75</td><td>10.73</td><td>4.97</td><td>&#8722;0.23</td><td>0.82</td></tr><tr><td>Cigarettes/week</td><td>24.66</td><td>28.67</td><td>n/a</td><td>n/a</td><td>n/a</td><td>n/a</td></tr><tr><td>Joints/week</td><td>11.14</td><td>12.16</td><td>n/a</td><td>n/a</td><td>n/a</td><td>n/a</td></tr><tr><td>Nicotine use severity</td><td>1.94</td><td>1.86</td><td>0.08</td><td>0.45</td><td>5.78</td><td>0.00</td></tr><tr><td>Cannabis use severity</td><td>2.97</td><td>1.95</td><td>0.00</td><td>0.00</td><td>9.03</td><td>0.00</td></tr><tr><td>Alcohol use severity</td><td>2.29</td><td>1.84</td><td>1.31</td><td>1.42</td><td>2.72</td><td>0.01</td></tr></table>
<table><tr><td>Variables</td><td colspan="2">CUc (N = 35)</td><td colspan="2">nCUd (N = 48)</td><td>t</td><td>p</td></tr><tr><td></td><td>Mean</td><td>SD</td><td>Mean</td><td>SD</td><td></td><td></td></tr><tr><td>Age</td><td>22.51</td><td>5.63</td><td>21.67</td><td>3.56</td><td>0.84</td><td>0.40</td></tr><tr><td>UnExa</td><td>7.63</td><td>6.04</td><td>5.44</td><td>3.71</td><td>1.90</td><td>0.06</td></tr></table>
<table><tr><td>Variables</td><td colspan="2">CUc (N = 35)</td><td colspan="2">nCUd (N = 48)</td><td>t</td><td>p</td></tr><tr><td></td><td>Mean</td><td>SD</td><td>Mean</td><td>SD</td><td></td><td></td></tr><tr><td>CogDisb</td><td>10.46</td><td>5.75</td><td>10.73</td><td>4.97</td><td>−0.23</td><td>0.82</td></tr><tr><td>Cigarettes/week</td><td>24.66</td><td>28.67</td><td>n/a</td><td>n/a</td><td>n/a</td><td>n/a</td></tr><tr><td>Joints/week</td><td>11.14</td><td>12.16</td><td>n/a</td><td>n/a</td><td>n/a</td><td>n/a</td></tr><tr><td>Nicotine use severity</td><td>1.94</td><td>1.86</td><td>0.08</td><td>0.45</td><td>5.78</td><td>0.00</td></tr><tr><td>Cannabis use severity</td><td>2.97</td><td>1.95</td><td>0.00</td><td>0.00</td><td>9.03</td><td>0.00</td></tr><tr><td>Alcohol use severity</td><td>2.29</td><td>1.84</td><td>1.31</td><td>1.42</td><td>2.72</td><td>0.01</td></tr></table>
cd3aef7a3f0331c4bed474aee5472084639cbd3a7d9000a8d04a9fb0897276d0.png
complex
<table><tr><td colspan="2"><i>ERAP2</i> genotype</td><td colspan="3">Fetal</td><td colspan="3">Maternal</td><td colspan="3">Total</td></tr><tr><td>rs2248374</td><td>rs2549782</td><td>Observed</td><td>Expected</td><td><i>P</i>-value</td><td>Observed</td><td>Expected</td><td><i>P</i>-value</td><td>Observed</td><td>Expected</td><td><i>P</i>-value</td></tr><tr><td>AA</td><td>TT</td><td>0</td><td>57</td><td>5.66 e-14</td><td>0</td><td>52</td><td>8.20 e-13</td><td>0</td><td>114</td><td>&lt;2.2 e-16</td></tr><tr><td>AA</td><td>TG</td><td>90</td><td>28</td><td>7.79 e-09</td><td>81</td><td>27</td><td>1.69 e-07</td><td>130</td><td>56</td><td>4.50 e-08</td></tr><tr><td>AA</td><td>GG</td><td>43</td><td>14</td><td>1.71 e-04</td><td>44</td><td>14</td><td>1.14 e-04</td><td>59</td><td>28</td><td>1.16 e-03</td></tr><tr><td>AG</td><td>TT</td><td>151</td><td>111</td><td>0.01</td><td>138</td><td>106</td><td>0.04</td><td>289</td><td>221</td><td>1.60 e-03</td></tr><tr><td>GG</td><td>TT</td><td>346</td><td>215</td><td>1.99 e-10</td><td>350</td><td>214</td><td>4.22 e-11</td><td>696</td><td>429</td><td>&lt;2.2 e-16</td></tr></table>
<table><tr><td colspan="2">ERAP2 genotype</td><td colspan="3">Fetal</td><td colspan="3">Maternal</td><td colspan="3">Total</td></tr><tr><td>rs2248374</td><td>rs2549782</td><td>Observed</td><td>Expected</td><td>P-value</td><td>Observed</td><td>Expected</td><td>P-value</td><td>Observed</td><td>Expected</td><td>P-value</td></tr><tr><td>AA</td><td>TT</td><td>0</td><td>57</td><td>5.66 e-14</td><td>0</td><td>52</td><td>8.20 e-13</td><td>0</td><td>114</td><td><2.2 e-16</td></tr><tr><td>AA</td><td>TG</td><td>90</td><td>28</td><td>7.79 e-09</td><td>81</td><td>27</td><td>1.69 e-07</td><td>130</td><td>56</td><td>4.50 e-08</td></tr><tr><td>AA</td><td>GG</td><td>43</td><td>14</td><td>1.71 e-04</td><td>44</td><td>14</td><td>1.14 e-04</td><td>59</td><td>28</td><td>1.16 e-03</td></tr><tr><td>AG</td><td>TT</td><td>151</td><td>111</td><td>0.01</td><td>138</td><td>106</td><td>0.04</td><td>289</td><td>221</td><td>1.60 e-03</td></tr><tr><td></td><td>TT</td><td>34</td><td></td><td>1.99</td><td>3</td><td>21</td><td>4.22 e-1</td><td>696</td><td></td><td><2.2 e-</td></tr></table>
<table><tr><td>GG</td><td>6</td><td>215</td><td> e-10</td><td>50</td><td>4</td><td>1</td><td>429</td><td>16</td></tr></table>
c3c4ee41f6c5ecde619048415fe5a3bd81fd9ab5cacbe7343b89357fd8b11c7b.png
complex
<table><tr><td colspan="2"></td><td colspan="5">Mycotoxin Content (&#956;g/kg) <sup>a</sup></td></tr><tr><td></td><td>% &gt;LOD</td><td>Mean</td><td>SEM <sup>b</sup></td><td>Median</td><td>90th Percentile</td><td>Maximum</td></tr><tr><td>DON</td><td>66</td><td>473</td><td>99</td><td>100</td><td>2510</td><td>9880</td></tr><tr><td>ZEA</td><td>22</td><td>18</td><td>7</td><td>5</td><td>47</td><td>1000</td></tr><tr><td>NIV</td><td>25</td><td>16</td><td>3</td><td>3</td><td>75</td><td>290</td></tr></table>
<table><tr><td colspan="2"></td><td colspan="5">Mycotoxin Content (μg/kg) a</td></tr><tr><td></td><td>% >LOD</td><td>Mean</td><td>SEM b</td><td>Median</td><td>90th Percentile</td><td>Maximum</td></tr><tr><td>DON</td><td>66</td><td>473</td><td>99</td><td>100</td><td>2510</td><td>9880</td></tr><tr><td>ZEA</td><td>22</td><td>18</td><td>7</td><td>5</td><td>47</td><td>1000</td></tr></table>
<table><tr><td>NIV</td><td>25</td><td>16</td><td>3</td><td>3</td><td>75</td><td>290</td></tr></table>
2904c6b03c61086147d06a53317ec618739c7ea753be8f3eae4c9c1e1dc4a9a5.png
complex
<table><tr><td>Country</td><td>Discount</td><td>Annual cash flow (profit/loss)</td><td>Present value of annual cash flow</td><td>Present value of all annual cash flows</td><td>Present value of terminal value<sup>a</sup></td><td>Total present value<sup>b</sup></td></tr><tr><td rowspan="3">Singapore</td><td>50% annually</td><td>3.13</td><td>0.41</td><td>1.51</td><td>4.13</td><td>5.64</td></tr><tr><td>25% annually</td><td>3.13</td><td>1.03</td><td>3.15</td><td>10.27</td><td>13.41</td></tr><tr><td>15% annually</td><td>3.13</td><td>1.56</td><td>4.42</td><td>15.58</td><td>20.00</td></tr><tr><td rowspan="3">Netherlands</td><td>50% annually</td><td>10.76</td><td>1.42</td><td>6.06</td><td>14.17</td><td>20.23</td></tr><tr><td>25% annually</td><td>10.76</td><td>3.53</td><td>12.12</td><td>35.27</td><td>47.39</td></tr><tr><td>15% annually</td><td>10.76</td><td>5.35</td><td>16.80</td><td>53.51</td><td>70.31</td></tr><tr><td rowspan="3">USA</td><td>50% annually</td><td>&#8722;94.76</td><td>0</td><td>0</td><td>0</td><td>0</td></tr><tr><td>25% annually</td><td>&#8722;94.76</td><td>0</td><td>0</td><td>0</td><td>0</td></tr><tr><td>15% annually</td><td>&#8722;94.76</td><td>0</td><td>0</td><td>0</td><td>0</td></tr></table>
<table><tr><td>Country</td><td>Discount</td><td>Annual cash flow (profit/loss)</td><td>Present value of annual cash flow</td><td>Present value of all annual cash flows</td><td>Present value of terminal valuea</td><td>Total present valueb</td></tr><tr><td rowspan="3">Singapore</td><td>50% annually</td><td>3.13</td><td>0.41</td><td>1.51</td><td>4.13</td><td>5.64</td></tr><tr><td>25% annually</td><td>3.13</td><td>1.03</td><td>3.15</td><td>10.27</td><td>13.41</td></tr><tr><td>15% annually</td><td>3.13</td><td>1.56</td><td>4.42</td><td>15.58</td><td>20.00</td></tr><tr><td rowspan="3">Netherlands</td><td>50% annually</td><td>10.76</td><td>1.42</td><td>6.06</td><td>14.17</td><td>20.23</td></tr><tr><td>25% annually</td><td>10.76</td><td>3.53</td><td>12.12</td><td>35.27</td><td>47.39</td></tr><tr><td>15% annually</td><td>10.76</td><td>5.35</td><td>16.80</td><td>53.51</td><td>70.31</td></tr></table>
<table><tr><td>Country</td><td>Discount</td><td>Annual cash flow (profit/loss)</td><td>Present value of annual cash flow</td><td>Present value of all annual cash flows</td><td>Present value of terminal valuea</td><td>Total present valueb</td></tr><tr><td rowspan="3">USA</td><td>50% annually</td><td>−94.76</td><td>0</td><td>0</td><td>0</td><td>0</td></tr><tr><td>25% annually</td><td>−94.76</td><td>0</td><td>0</td><td>0</td><td>0</td></tr><tr><td>15% annually</td><td>−94.76</td><td>0</td><td>0</td><td>0</td><td>0</td></tr></table>
e1be260af39ff0e3bf43390e73da0257c46f66c0ecc255438ecdb98f478b3ee9.png
simple
<table><tr><td>Order</td><td> Symbol</td><td>Name</td><td>Similarity</td><td>Parameter</td><td>Remark</td></tr><tr><td>1</td><td>CENP-E</td><td>kinesin</td><td>0. 8169</td><td>3</td><td> </td></tr><tr><td>2</td><td>GCN4</td><td> </td><td>0.7611</td><td>3</td><td>monomer yeast transcriptional activator</td></tr><tr><td>3</td><td>ROCK1</td><td>Serine kinase</td><td>0.7394</td><td>3</td><td>Rho-associated,coiled-coil containing protein kinase 1</td></tr><tr><td>6</td><td>CENP-B</td><td> </td><td>0.7297</td><td>3</td><td> </td></tr><tr><td>4</td><td>PAK1</td><td> </td><td>0.6481</td><td>3</td><td>P21 activated kinase</td></tr><tr><td>7</td><td>GP41-HIV</td><td> </td><td>0. 6010</td><td>3</td><td> </td></tr><tr><td>8</td><td>ATG12</td><td> </td><td>0.4749</td><td>3</td><td> </td></tr><tr><td>5</td><td>ROCK2</td><td> </td><td>0.4478</td><td>3</td><td> </td></tr><tr><td>9</td><td>CENP-A</td><td> </td><td>0</td><td>0</td><td> </td></tr></table>
<table><tr><td>Order</td><td>Symbol</td></tr><tr><td>1</td><td>CENP-E</td></tr><tr><td>2</td><td>GCN4</td></tr><tr><td>3</td><td>ROCK1</td></tr><tr><td>6</td><td>CENP-B</td></tr><tr><td>4</td><td>PAK1</td></tr><tr><td>7</td><td>GP41-HIV</td></tr><tr><td>8</td><td>ATG12</td></tr><tr><td>5</td><td>ROCK2</td></tr><tr><td>9</td><td>CENP-A</td></tr></table>
<table><tr><td>Name</td><td>Similarity</td><td>Parameter</td><td>Remark</td></tr><tr><td>kinesin</td><td>0. 8169</td><td>3</td><td></td></tr><tr><td></td><td>0.7611</td><td>3</td><td>monomer yeast transcriptional activator</td></tr><tr><td>Serine kinase</td><td>0.7394</td><td>3</td><td>Rho-associated,coiled-coil containing protein kinase 1</td></tr><tr><td></td><td>0.7297</td><td>3</td><td></td></tr><tr><td></td><td>0.6481</td><td>3</td><td>P21 activated kinase</td></tr><tr><td></td><td>0. 6010</td><td>3</td><td></td></tr><tr><td></td><td>0.4749</td><td>3</td><td></td></tr><tr><td></td><td>0.4478</td><td>3</td><td></td></tr><tr><td></td><td>0</td><td>0</td><td></td></tr></table>
0a5bc461fdd8bf0046ad3b199a282049d5d156cec063036b101bb5218043b0aa.png
simple
<table><tr><td></td><td></td><td>high secure-intensive care</td><td>Male admission/high secure</td><td>Male medium secure-1</td><td>Male medium secure-2</td><td>Long term low security</td><td>Male low secure rehab</td><td>Male pre-discharge/community h1gh support</td><td>ANOVADf = 6</td></tr><tr><td>N</td><td></td><td>7</td><td>10</td><td>14</td><td>16</td><td>10</td><td>15</td><td>15</td><td>F/p</td></tr><tr><td>GAF</td><td>mean</td><td>34.6</td><td>45.8</td><td>47.4</td><td>54.4</td><td>47.8</td><td>60.5</td><td>73</td><td>13.8/0.001</td></tr><tr><td></td><td>95% CI</td><td>20.3-48.8</td><td>35.3-56.3</td><td>39.8-55.1</td><td>49.2-59.5</td><td>40.3-55.3</td><td>56.7-64.4</td><td>67.6-78.4</td><td></td></tr><tr><td>PANSS positive</td><td>mean</td><td>21.4</td><td>13.6</td><td>17.9</td><td>13.3</td><td>14.6</td><td>11.3</td><td>8.9</td><td>5.4/0.001</td></tr><tr><td></td><td>95% CI</td><td>13.4-29.5</td><td>11.1-16.1</td><td>13.7-22.1</td><td>10.5-16.2</td><td>8.7-20.5</td><td>8.6-13.9</td><td>7.1-10.6</td><td></td></tr><tr><td>PANSS negative</td><td>mean</td><td>23.6</td><td>22.3</td><td>21.9</td><td>15.6</td><td>21.1</td><td>17.0</td><td>10.9</td><td>5.9/0.001</td></tr><tr><td></td><td>95% CI</td><td>16.3-30.8</td><td>16.1-28.5</td><td>17.4-26.4</td><td>12.6-18.5</td><td>16.1-26.2</td><td>13.4-20.6</td><td>8.7-12.9</td><td></td></tr><tr><td>PANSS general</td><td>mean</td><td>37.6</td><td>31.5</td><td>32.4</td><td>28.8</td><td>29.1</td><td>25.9</td><td>21.9</td><td>3.5/0.008</td></tr><tr><td></td><td>95% CI</td><td>27.0-48.1</td><td>24.7-38.3</td><td>27.4-37.5</td><td>23.6-34.0</td><td>21.8-36.4</td><td>21.5-30.4</td><td>18.8-36.4</td><td></td></tr><tr><td>PANSS total</td><td>mean</td><td>82.6</td><td>67.4</td><td>72.3</td><td>57.7</td><td>64.8</td><td>54.2</td><td>41.6</td><td>5.6/0.001</td></tr><tr><td></td><td>95% CI</td><td>57.9-107.2</td><td>54.8-79.9</td><td>60.2-84.4</td><td>47.9-67.5</td><td>48.4-81.2</td><td>44.1-64.3</td><td>35.7-47.5</td><td></td></tr><tr><td>CANFOR staff met needs</td><td>mean</td><td>7.0</td><td>6.1</td><td>6.1</td><td>8.1</td><td>6.9</td><td>6.5</td><td>7.0</td><td>0.9/0.5 (NS)</td></tr><tr><td></td><td>95% CI</td><td>4.2-9.8</td><td>4.6-7.6</td><td>4.1-7.9</td><td>6.6-9.5</td><td>4.8-8.9</td><td>5.4-7.5</td><td>5.7-8.3</td><td></td></tr><tr><td>CANFOR staff unmet needs</td><td>mean</td><td>5.7</td><td>3.1</td><td>4.4</td><td>2.9</td><td>2.7</td><td>1.4</td><td>1.0</td><td>5.9/0.001</td></tr><tr><td></td><td>95% CI</td><td>3.5-7.9</td><td>1.5-4.7</td><td>2.2-6.7</td><td>2.0-3.9</td><td>1.2-4.2</td><td>0.8-2.0</td><td>0.4-1.6</td><td></td></tr><tr><td>CANFOR staff total needs</td><td>mean</td><td>12.7</td><td>9.2</td><td>10.5</td><td>11.0</td><td>9.6</td><td>7.9</td><td>8.0</td><td>2.2/0.052 (NS)</td></tr><tr><td></td><td>95% CI</td><td>8.7-16.7</td><td>6.3-12.1</td><td>7.3-13.7</td><td>9.1-12.9</td><td>6.2-12.9</td><td>6.8-8.9</td><td>6.6-9.4</td><td></td></tr></table>
<table><tr><td></td><td></td><td>high secure-intensive care</td><td>Male admission/high secure</td><td>Male medium secure-1</td><td>Male medium secure-2</td><td>Long term low security</td><td>Male low secure rehab</td><td>Male pre-discharge/community h1gh support</td><td>ANOVADf = 6</td></tr></table>
<table><tr><td>N</td><td></td><td>7</td><td>10</td><td>14</td><td>16</td><td>10</td><td>15</td><td>15</td><td>F/p</td></tr><tr><td>GAF</td><td>mean</td><td>34.6</td><td>45.8</td><td>47.4</td><td>54.4</td><td>47.8</td><td>60.5</td><td>73</td><td>13.8/0.001</td></tr><tr><td></td><td>95% CI</td><td>20.3-48.8</td><td>35.3-56.3</td><td>39.8-55.1</td><td>49.2-59.5</td><td>40.3-55.3</td><td>56.7-64.4</td><td>67.6-78.4</td><td></td></tr><tr><td>PANSS positive</td><td>mean</td><td>21.4</td><td>13.6</td><td>17.9</td><td>13.3</td><td>14.6</td><td>11.3</td><td>8.9</td><td>5.4/0.001</td></tr><tr><td></td><td>95% CI</td><td>13.4-29.5</td><td>11.1-16.1</td><td>13.7-22.1</td><td>10.5-16.2</td><td>8.7-20.5</td><td>8.6-13.9</td><td>7.1-10.6</td><td></td></tr><tr><td>PANSS negative</td><td>mean</td><td>23.6</td><td>22.3</td><td>21.9</td><td>15.6</td><td>21.1</td><td>17.0</td><td>10.9</td><td>5.9/0.001</td></tr><tr><td></td><td>95% CI</td><td>16.3-30.8</td><td>16.1-28.5</td><td>17.4-26.4</td><td>12.6-18.5</td><td>16.1-26.2</td><td>13.4-20.6</td><td>8.7-12.9</td><td></td></tr><tr><td>PANSS general</td><td>mean</td><td>37.6</td><td>31.5</td><td>32.4</td><td>28.8</td><td>29.1</td><td>25.9</td><td>21.9</td><td>3.5/0.008</td></tr><tr><td></td><td>95% CI</td><td>27.0-48.1</td><td>24.7-38.3</td><td>27.4-37.5</td><td>23.6-34.0</td><td>21.8-36.4</td><td>21.5-30.4</td><td>18.8-36.4</td><td></td></tr><tr><td>PANSS total</td><td>mean</td><td>82.6</td><td>67.4</td><td>72.3</td><td>57.7</td><td>64.8</td><td>54.2</td><td>41.6</td><td>5.6/0.001</td></tr><tr><td></td><td>95% CI</td><td>57.9-107.2</td><td>54.8-79.9</td><td>60.2-84.4</td><td>47.9-67.5</td><td>48.4-81.2</td><td>44.1-64.3</td><td>35.7-47.5</td><td></td></tr><tr><td>CANFOR staff met needs</td><td>mean</td><td>7.0</td><td>6.1</td><td>6.1</td><td>8.1</td><td>6.9</td><td>6.5</td><td>7.0</td><td>0.9/0.5 (NS)</td></tr><tr><td></td><td>95% CI</td><td>4.2-9.8</td><td>4.6-7.6</td><td>4.1-7.9</td><td>6.6-9.5</td><td>4.8-8.9</td><td>5.4-7.5</td><td>5.7-8.3</td><td></td></tr><tr><td>CANFOR staff unmet needs</td><td>mean</td><td>5.7</td><td>3.1</td><td>4.4</td><td>2.9</td><td>2.7</td><td>1.4</td><td>1.0</td><td>5.9/0.001</td></tr><tr><td></td><td>95% CI</td><td>3.5-7.9</td><td>1.5-4.7</td><td>2.2-6.7</td><td>2.0-3.9</td><td>1.2-4.2</td><td>0.8-2.0</td><td>0.4-1.6</td><td></td></tr><tr><td>CANFOR staff total needs</td><td>mean</td><td>12.7</td><td>9.2</td><td>10.5</td><td>11.0</td><td>9.6</td><td>7.9</td><td>8.0</td><td>2.2/0.052 (NS)</td></tr><tr><td></td><td>95% CI</td><td>8.7-16.7</td><td>6.3-12.1</td><td>7.3-13.7</td><td>9.1-12.9</td><td>6.2-12.9</td><td>6.8-8.9</td><td>6.6-9.4</td><td></td></tr></table>
2420ef2c057ef530a1f23322e68f8978665b3a21e8cd928abbb197dfc6ce6926.png
simple
<table><tr><td>Measurement<sup>a</sup></td><td>No. (%)</td></tr><tr><td>Range of motion (knee)</td><td>34 (57)</td></tr><tr><td>X-ray (knee)</td><td>19 (32)</td></tr><tr><td>Pain score (knee)</td><td>10 (17)</td></tr><tr><td>Subjects were asked to first stand and then walk along a 10 m walkway</td><td>5 (8)</td></tr><tr><td>Range of motion (shoulder)</td><td>5 (8)</td></tr><tr><td>Pain score (shoulder)</td><td>5 (8)</td></tr><tr><td>Stability of joint function (stabilometry)</td><td>4 (7)</td></tr><tr><td>Pain score (upper limb)</td><td>4 (7)</td></tr><tr><td>Hand grip strength</td><td>3 (5)</td></tr><tr><td>Range of motion (hip)</td><td>3 (5)</td></tr><tr><td>Strength of the knee extensors</td><td>3 (5)</td></tr><tr><td>Chair rise test</td><td>2 (3)</td></tr><tr><td>Muscle power (shoulder)</td><td>2 (3)</td></tr><tr><td>Range of motion (ankle)</td><td>2 (3)</td></tr><tr><td>Range of motion (finger/wrist)</td><td>2 (3)</td></tr><tr><td>Range of motion (lower limb, matching task)</td><td>2 (3)</td></tr><tr><td>X-ray (elbow)</td><td>2 (3)</td></tr><tr><td>X-ray (hip)</td><td>2 (3)</td></tr><tr><td>X-ray (shoulder)</td><td>2 (3)</td></tr></table>
<table><tr><td>Measurementa</td><td>No. (%)</td></tr><tr><td>Range of motion (knee)</td><td>34 (57)</td></tr><tr><td>X-ray (knee)</td><td>19 (32)</td></tr><tr><td>Pain score (knee)</td><td>10 (17)</td></tr><tr><td>Subjects were asked to first stand and then walk along a 10 m walkway</td><td>5 (8)</td></tr><tr><td>Range of motion (shoulder)</td><td>5 (8)</td></tr><tr><td>Pain score (shoulder)</td><td>5 (8)</td></tr><tr><td>Stability of joint function (stabilometry)</td><td>4 (7)</td></tr><tr><td>Pain score (upper limb)</td><td>4 (7)</td></tr><tr><td>Hand grip strength</td><td>3 (5)</td></tr><tr><td>Range of motion (hip)</td><td>3 (5)</td></tr><tr><td>Strength of the knee extensors</td><td>3 (5)</td></tr></table>
<table><tr><td>Measurementa</td><td>No. (%)</td></tr><tr><td>Chair rise test</td><td>2 (3)</td></tr><tr><td>Muscle power (shoulder)</td><td>2 (3)</td></tr><tr><td>Range of motion (ankle)</td><td>2 (3)</td></tr><tr><td>Range of motion (finger/wrist)</td><td>2 (3)</td></tr><tr><td>Range of motion (lower limb, matching task)</td><td>2 (3)</td></tr><tr><td>X-ray (elbow)</td><td>2 (3)</td></tr><tr><td>X-ray (hip)</td><td>2 (3)</td></tr><tr><td>X-ray (shoulder)</td><td>2 (3)</td></tr></table>
24272b6514eb993ce01aa88bf28a7cf2931d1f0d836e476e521738d38b83c7ac.png
simple
<table><tr><td>Compound</td><td>Adsorption capacity, &#956;mol g<sup>&#8722;1</sup></td><td>Distribution coefficient (<i>k</i>), g L<sup>&#8722;1</sup></td></tr><tr><td>1-Naphthol</td><td>62</td><td>200</td></tr><tr><td>2-Naphthol</td><td>60</td><td>170</td></tr><tr><td>Resorcinol</td><td>59</td><td>190</td></tr><tr><td>Phenol</td><td>0 &#177; 2</td><td>&#8211;</td></tr></table>
<table><tr><td>Compound</td><td>Adsorption capacity, μmol g−1</td></tr><tr><td>1-Naphthol</td><td>62</td></tr><tr><td>2-Naphthol</td><td>60</td></tr><tr><td>Resorcinol</td><td>59</td></tr><tr><td>Phenol</td><td>0 ± 2</td></tr></table>
<table><tr><td>Distribution coefficient (k), g L−1</td></tr><tr><td>200</td></tr><tr><td>170</td></tr><tr><td>190</td></tr><tr><td>–</td></tr></table>
7c771c9b7d017b7a4e93047436ddc7bc9e4866c24ddcb1e723efc2ede46ebe38.png
complex
<table><tr><td>Characteristic</td><td>Value</td><td>ICUSteps</td><td>UCCDIP</td><td>Verbal</td><td>Total</td><td>p Value</td></tr><tr><td>Age (years)</td><td>Mean&#177;SD</td><td>59&#177;15.26</td><td>60&#177;15.19</td><td>61&#177;17.48</td><td>60&#177;16.04</td><td>0.72</td></tr><tr><td>Ethnicity (white British)</td><td>n (%)</td><td>34 (71)</td><td>40 (78)</td><td>41 (69)</td><td>115 (73)</td><td>0.54</td></tr><tr><td>Gender (male)</td><td>n (%)</td><td>25 (52)</td><td>26 (51)</td><td>31 (53)</td><td>82 (52)</td><td>0.99</td></tr><tr><td>Medical/Surgical ICU</td><td>Medical, n (%)</td><td>28 (58)</td><td>28 (55)</td><td>26 (44)</td><td>82 (52)</td><td>0.30</td></tr><tr><td>Admission type (emergency)</td><td>n (%)</td><td>38 (79)</td><td>40 (78)</td><td>44 (75)</td><td>122 (77)</td><td>0.83</td></tr><tr><td rowspan="2">APACHE II score</td><td>ICU admissionMedian (range)</td><td>17 (24)</td><td>18.0 (30)</td><td>16.0 (29)</td><td>17.0 (30)</td><td>0.41</td></tr><tr><td>ICU discharge Median (range)</td><td>8.0 (20)</td><td>9.5 (20)</td><td>9.0 (21)</td><td>9.0 (21)</td><td>0.66</td></tr><tr><td rowspan="2">Length of stay</td><td>ICU daysMedian (range)</td><td>6.0 (62)</td><td>7.0 (104)</td><td>6.0 (371)</td><td>6.0 (371)</td><td>0.24</td></tr><tr><td>Hospital daysMedian (range)</td><td>16.0 (132)</td><td>21.5 (220)</td><td>22.0 (166)</td><td>21.0 (221)</td><td>0.25</td></tr><tr><td>Level 3 critical illness</td><td>n (%)</td><td>29 (60)</td><td>35 (69)</td><td>34 (58)</td><td>98 (62)</td><td>0.58</td></tr><tr><td>Total number of participants</td><td>n (%)</td><td>48 (100)</td><td>51 (100)</td><td>59 (100)</td><td>158 (100)</td><td>NA</td></tr></table>
<table><tr><td>Characteristic</td><td>Value</td><td>ICUSteps</td><td>UCCDIP</td><td>Verbal</td><td>Total</td><td>p Value</td></tr><tr><td>Age (years)</td><td>Mean±SD</td><td>59±15.26</td><td>60±15.19</td><td>61±17.48</td><td>60±16.04</td><td>0.72</td></tr><tr><td>Ethnicity (white British)</td><td>n (%)</td><td>34 (71)</td><td>40 (78)</td><td>41 (69)</td><td>115 (73)</td><td>0.54</td></tr><tr><td>Gender (male)</td><td>n (%)</td><td>25 (52)</td><td>26 (51)</td><td>31 (53)</td><td>82 (52)</td><td>0.99</td></tr><tr><td>Medical/Surgical ICU</td><td>Medical, n (%)</td><td>28 (58)</td><td>28 (55)</td><td>26 (44)</td><td>82 (52)</td><td>0.30</td></tr><tr><td>Admission type (emergency)</td><td>n (%)</td><td>38 (79)</td><td>40 (78)</td><td>44 (75)</td><td>122 (77)</td><td>0.83</td></tr></table>
<table><tr><td rowspan="2">APACHE II score</td><td>ICU admissionMedian (range)</td><td>17 (24)</td><td>18.0 (30)</td><td>16.0 (29)</td><td>17.0 (30)</td><td>0.41</td></tr><tr><td>ICU discharge Median (range)</td><td>8.0 (20)</td><td>9.5 (20)</td><td>9.0 (21)</td><td>9.0 (21)</td><td>0.66</td></tr><tr><td rowspan="2">Length of stay</td><td>ICU daysMedian (range)</td><td>6.0 (62)</td><td>7.0 (104)</td><td>6.0 (371)</td><td>6.0 (371)</td><td>0.24</td></tr><tr><td>Hospital daysMedian (range)</td><td>16.0 (132)</td><td>21.5 (220)</td><td>22.0 (166)</td><td>21.0 (221)</td><td>0.25</td></tr><tr><td>Level 3 critical illness</td><td>n (%)</td><td>29 (60)</td><td>35 (69)</td><td>34 (58)</td><td>98 (62)</td><td>0.58</td></tr><tr><td>Total number of participants</td><td>n (%)</td><td>48 (100)</td><td>51 (100)</td><td>59 (100)</td><td>158 (100)</td><td>NA</td></tr></table>
5e3fdeb3784f3a0b98619228bb7b7a82e293fcb24cdf3afc15a18f6aeb8f4cab.png
simple
<table><tr><td></td><td>Group 1</td><td>Group 2</td><td>Chi-square</td><td>Significance (p value)</td></tr><tr><td>A</td><td>123/339 (36.3 %)</td><td>84/370 (22.7 %)</td><td>15.784</td><td>&lt;0.001</td></tr><tr><td>B</td><td>146/339 (43.1 %)</td><td>99/370 (26.8 %)</td><td>20.813</td><td>&lt;0.001</td></tr><tr><td>C</td><td>14/339 (4.1 %)</td><td>19/370 (5.1 %)</td><td>0.403</td><td>0.594</td></tr><tr><td>D</td><td>144/339 (42.5 %)</td><td>143/370 (38.6 %)</td><td>1.077</td><td>0.320</td></tr><tr><td>E</td><td>68/339 (20.1 %)</td><td>93/370 (25.1 %)</td><td>2.597</td><td>0.127</td></tr><tr><td>F</td><td>79/339 (23.3 %)</td><td>132/370 (35.7 %)</td><td>12.954</td><td>&lt;0.001</td></tr><tr><td>G</td><td>162/339 (47.8 %)</td><td>200/370 (54.1 %)</td><td>2.780</td><td>0.099</td></tr></table>
<table><tr><td></td><td>Group 1</td><td>Group 2</td><td>Chi-square</td><td>Significance (p value)</td></tr></table>
<table><tr><td>A</td><td>123/339 (36.3 %)</td><td>84/370 (22.7 %)</td><td>15.784</td><td><0.001</td></tr><tr><td>B</td><td>146/339 (43.1 %)</td><td>99/370 (26.8 %)</td><td>20.813</td><td><0.001</td></tr><tr><td>C</td><td>14/339 (4.1 %)</td><td>19/370 (5.1 %)</td><td>0.403</td><td>0.594</td></tr><tr><td>D</td><td>144/339 (42.5 %)</td><td>143/370 (38.6 %)</td><td>1.077</td><td>0.320</td></tr><tr><td>E</td><td>68/339 (20.1 %)</td><td>93/370 (25.1 %)</td><td>2.597</td><td>0.127</td></tr><tr><td>F</td><td>79/339 (23.3 %)</td><td>132/370 (35.7 %)</td><td>12.954</td><td><0.001</td></tr><tr><td>G</td><td>162/339 (47.8 %)</td><td>200/370 (54.1 %)</td><td>2.780</td><td>0.099</td></tr></table>
710b858fb2cb5cbe044cfcbd2ad6d6ba6a4cf624d3ffd03b0ebfaa812fec01ba.png
complex
<table><tr><td></td><td colspan="5">Seroprotection status</td><td></td></tr><tr><td>Vaccine strain</td><td></td><td colspan="2">Young cohort (<i>n</i> = 58)</td><td colspan="2">Older cohort (<i>n</i> = 54)</td><td><i>p</i></td></tr><tr><td></td><td></td><td>Placebo</td><td><i>B. longum</i> + Gl-OS</td><td>Placebo</td><td><i>B. longum</i> + Gl-OS</td><td></td></tr><tr><td></td><td></td><td>n/N (%)</td><td>n/N (%)</td><td>n/N (%)</td><td>n/N (%)</td><td></td></tr><tr><td rowspan="2">A/California/7/2009 (H1N1)</td><td>Before</td><td>20/29 (69)<sup>a</sup></td><td>13/29 (45)<sup>a</sup></td><td>5/28 (18)</td><td>1/26 (4)</td><td>&lt; 0.001</td></tr><tr><td>After</td><td>29/29 (100)</td><td>27/29 (93)<sup>a</sup></td><td>22/27 (81)</td><td>16/26 (62)</td><td>&lt; 0.001</td></tr><tr><td rowspan="2">A/Perth/16/2009 (H3N2)</td><td>Before</td><td>10/29 (34)</td><td>13/29 (45)</td><td>8/28 (29)</td><td>12/26 (46)</td><td>NS</td></tr><tr><td>After</td><td>26/29 (90)</td><td>27/29 (93)</td><td>25/27 (93)</td><td>22/26 (85)</td><td>NS</td></tr><tr><td rowspan="2">B/Brisbane/60/2008</td><td>Before</td><td>4/29 (14)</td><td>0/29 (0)</td><td>4/24 (17)</td><td>5/26 (19)</td><td>NS</td></tr><tr><td>After</td><td>28/29 (97)</td><td>20/29 (76)</td><td>14/27 (52)</td><td>11/26 (42)</td><td>&lt; 0.001</td></tr></table>
<table><tr><td></td><td colspan="2">Seroprotection status</td></tr><tr><td>Vaccine strain</td><td></td><td>Young cohort (n = 58)</td></tr><tr><td></td><td></td><td>Placebo</td></tr><tr><td></td><td></td><td>n/N (%)</td></tr><tr><td rowspan="2">A/California/7/2009 (H1N1)</td><td>Before</td><td>20/29 (69)a</td></tr><tr><td>After</td><td>29/29 (100)</td></tr><tr><td rowspan="2">A/Perth/16/2009 (H3N2)</td><td>Before</td><td>10/29 (34)</td></tr><tr><td>After</td><td>26/29 (90)</td></tr><tr><td rowspan="2">B/Brisbane/60/2008</td><td>Before</td><td>4/29 (14)</td></tr><tr><td>After</td><td>28/29 (97)</td></tr></table>
<table><tr><td colspan="3">Seroprotection status</td><td></td></tr><tr><td>Young cohort (n = 58)</td><td colspan="2">Older cohort (n = 54)</td><td>p</td></tr><tr><td>B. longum + Gl-OS</td><td>Placebo</td><td>B. longum + Gl-OS</td><td></td></tr><tr><td>n/N (%)</td><td>n/N (%)</td><td>n/N (%)</td><td></td></tr><tr><td>13/29 (45)a</td><td>5/28 (18)</td><td>1/26 (4)</td><td>< 0.001</td></tr><tr><td>27/29 (93)a</td><td>22/27 (81)</td><td>16/26 (62)</td><td>< 0.001</td></tr><tr><td>13/29 (45)</td><td>8/28 (29)</td><td>12/26 (46)</td><td>NS</td></tr><tr><td>27/29 (93)</td><td>25/27 (93)</td><td>22/26 (85)</td><td>NS</td></tr><tr><td>0/29 (0)</td><td>4/24 (17)</td><td>5/26 (19)</td><td>NS</td></tr><tr><td>20/29 (76)</td><td>14/27 (52)</td><td>11/26 (42)</td><td>< 0.001</td></tr></table>
945efc775b00d125bcd4fead53b408298336c3fb8ed93532f39a7ffadafa0678.png
simple
<table><tr><td>Sampling date</td><td>ACE</td><td><i>Chao</i>1</td><td>Shannon diversity (<i>H</i><i>'</i>)</td><td>Simpson diversity (1/<i>D</i>)</td></tr><tr><td>Jul. 13</td><td>383(363,415)</td><td>386(361,433)</td><td>3.58(3.55,3.62)</td><td>11(11,11)</td></tr><tr><td>Jul. 31</td><td>409(386,445)</td><td>405(380,451)</td><td>4.19(4.16,4.22)</td><td>25(25,25)</td></tr><tr><td>Aug. 16</td><td>463(443,495)</td><td>458(436,498)</td><td>3.99(3.96,4.03)</td><td>16(16,16)</td></tr><tr><td>Sep. 1</td><td>507(493,531)</td><td>514(494,552)</td><td>4.33(4.31,4.35)</td><td>33(33,33)</td></tr><tr><td>Sep. 15</td><td>459(436,493)</td><td>454(429,497)</td><td>4.18(4.15,4.21)</td><td>25(25,25)</td></tr><tr><td>Sep. 30</td><td>401(381,435)</td><td>399(375,442)</td><td>4.43(4.39,4.46)</td><td>33(33,33)</td></tr></table>
<table><tr><td>Sampling date</td><td>ACE</td><td>Chao1</td><td>Shannon diversity (H')</td><td>Simpson diversity (1/D)</td></tr><tr><td>Jul. 13</td><td>383(363,415)</td><td>386(361,433)</td><td>3.58(3.55,3.62)</td><td>11(11,11)</td></tr><tr><td>Jul. 31</td><td>409(386,445)</td><td>405(380,451)</td><td>4.19(4.16,4.22)</td><td>25(25,25)</td></tr><tr><td>Aug. 16</td><td>463(443,495)</td><td>458(436,498)</td><td>3.99(3.96,4.03)</td><td>16(16,16)</td></tr><tr><td>Sep. 1</td><td>507(493,531)</td><td>514(494,552)</td><td>4.33(4.31,4.35)</td><td>33(33,33)</td></tr><tr><td>Sep. 15</td><td>459(436,493)</td><td>454(429,497)</td><td>4.18(4.15,4.21)</td><td>25(25,25)</td></tr></table>
<table><tr><td>Sampling date</td><td>ACE</td><td>Chao1</td><td>Shannon diversity (H')</td><td>Simpson diversity (1/D)</td></tr><tr><td>Sep. 30</td><td>401(381,435)</td><td>399(375,442)</td><td>4.43(4.39,4.46)</td><td>33(33,33)</td></tr></table>
8d706275f8cb4e01b9257fa67b3b5f88de8d527909879c06ad5183eef3c45252.png
complex
<table><tr><td rowspan="2"></td><td colspan="3">Creatinine-Cystatin C-based eGFR, ml/min/1.73 m<sup>2</sup></td><td colspan="3">C-reactive protein levels, mg/L</td></tr><tr><td>&#8805;60(<i>n</i> = 1750)</td><td>&lt;60(<i>n</i> = 605)</td><td><i>P</i>-value</td><td>&lt;3(<i>n</i> = 1564)</td><td>&#8805;3(<i>n</i> = 791)</td><td><i>P</i>-value</td></tr><tr><td>Age, years</td><td>71.2 &#177; 5.04</td><td>75.4 &#177; 5.3</td><td>&lt;0.001</td><td>72.0 &#177; 5.3</td><td>72.7 &#177; 5.6</td><td>0.004</td></tr><tr><td>Men, No. (%)</td><td>1465 (83.7%)</td><td>422 (69.8%)</td><td>&lt;0.001</td><td>1291 (82.5%)</td><td>596 (75.3%)</td><td>&lt;0.001</td></tr><tr><td>Higher education <sup>a</sup>, <i>n</i> (%)</td><td>767 (44.0%)</td><td>238 (39.7%)</td><td>0.064</td><td>715 (45.9%)</td><td>290 (36.9%)</td><td>&lt;0.001</td></tr><tr><td>Body mass index<sup>b</sup>, kg/m<sup>2</sup></td><td>27.6 &#177; 3.6</td><td>28.1 &#177; 4.1</td><td>0.003</td><td>27.3 &#177; 3.4</td><td>28.6 &#177; 4.15</td><td>&lt;0.001</td></tr><tr><td>Physically active<sup>c</sup>, <i>n</i> (%)</td><td>389 (22.3%)</td><td>87 (14.5%)</td><td>&lt;0.001</td><td>340 (21.8%)</td><td>136 (17.3%)</td><td>0.010</td></tr><tr><td>Current smoker, <i>n</i> (%)</td><td>267 (15.3%)</td><td>83 (13.8%)</td><td>0.363</td><td>184 (11.8%)</td><td>166 (21.0%)</td><td>&lt;0.001</td></tr><tr><td>Alcohol use &#8805;1 glass/week, <i>n</i> (%)</td><td>1286 (73.6%)</td><td>360 (59.9%)</td><td>&lt;0.001</td><td>1135 (72.8%)</td><td>510 (64.8%)</td><td>&lt;0.001</td></tr><tr><td>Antidepressant use, <i>n</i> (%)</td><td>78 (4.5%)</td><td>40 (6.6%)</td><td>0.036</td><td>67 (4.3%)</td><td>51 (6.4%)</td><td>0.023</td></tr><tr><td>Time since myocardial infarction, years</td><td>4.5 &#177; 3.1</td><td>4.7 &#177; 3.4</td><td>0.110</td><td>4.5 &#177; 3.2</td><td>4.7 &#177; 3.2</td><td>0.117</td></tr><tr><td>Self-reported history of stroke, <i>n</i> (%)</td><td>94 (5.4%)</td><td>58 (9.7%)</td><td>&lt;0.001</td><td>84 (5.4%)</td><td>68 (8.7%)</td><td>0.003</td></tr><tr><td>Diabetes<sup>d</sup>, <i>n</i> (%)</td><td>93.1 (22.3%)</td><td>188 (31.1%)</td><td>&lt;0.001</td><td>375 (24.0%)</td><td>204 (25.8%)</td><td>0.334</td></tr><tr><td>Systolic blood pressure, mmHg</td><td>142.9 &#177; 20.5</td><td>141.6 &#177; 23.7</td><td>0.188</td><td>143.4 &#177; 20.9</td><td>140.9 &#177; 22.1</td><td>0.006</td></tr><tr><td colspan="7">Use of cardiovascular medication<sup>e</sup>, <i>n</i> (%)</td></tr><tr><td> Antithrombotic agents</td><td>1713 (97.9%)</td><td>584 (96.5%)</td><td>0.063</td><td>1529 (97.8%)</td><td>768 (97.1%)</td><td>0.322</td></tr><tr><td> Blood pressure lowering drugs</td><td>1729 (98.8%)</td><td>591 (97.7%)</td><td>0.051</td><td>1537 (98.3%)</td><td>783 (99.0%)</td><td>0.176</td></tr><tr><td> Statins</td><td>1553 (88.7%)</td><td>513 (84.8%)</td><td>0.011</td><td>1399 (89.5%)</td><td>667 (84.3%)</td><td>&lt;0.001</td></tr><tr><td>High-sensitivity C-reactive protein, mg/L</td><td>1.42 (0.71-3.15)</td><td>3.33 (1.27-6.91)</td><td>&lt;0.001</td><td>1.01 (0.61-1.72)</td><td>5.66 (4.04-8.83)</td><td>&lt;0.001</td></tr><tr><td>Serum creatinine<sup>f</sup>, mg/dl</td><td>0.96 &#177; 0.18</td><td>1.54 &#177; 0.61</td><td>&lt;0.001</td><td>1.05 &#177; 0.33</td><td>1.22 &#177; 0.56</td><td>&lt;0.001</td></tr><tr><td>Serum cystatin C, mg/L</td><td>0.89 &#177; 0.13</td><td>1.41 &#177; 0.42</td><td>&lt;0.001</td><td>0.96 &#177; 0.24</td><td>1.15 &#177; 0.42</td><td>&lt;0.001</td></tr></table>
<table><tr><td rowspan="2"></td><td colspan="3">Creatinine-Cystatin C-based eGFR, ml/min/1.73 m2</td><td colspan="3">C-reactive protein levels, mg/L</td></tr><tr><td>≥60(n = 1750)</td><td><60(n = 605)</td><td>P-value</td><td><3(n = 1564)</td><td>≥3(n = 791)</td><td>P-value</td></tr><tr><td>Age, years</td><td>71.2 ± 5.04</td><td>75.4 ± 5.3</td><td><0.001</td><td>72.0 ± 5.3</td><td>72.7 ± 5.6</td><td>0.004</td></tr><tr><td>Men, No. (%)</td><td>1465 (83.7%)</td><td>422 (69.8%)</td><td><0.001</td><td>1291 (82.5%)</td><td>596 (75.3%)</td><td><0.001</td></tr><tr><td>Higher education a, n (%)</td><td>767 (44.0%)</td><td>238 (39.7%)</td><td>0.064</td><td>715 (45.9%)</td><td>290 (36.9%)</td><td><0.001</td></tr><tr><td>Body mass indexb, kg/m2</td><td>27.6 ± 3.6</td><td>28.1 ± 4.1</td><td>0.003</td><td>27.3 ± 3.4</td><td>28.6 ± 4.15</td><td><0.001</td></tr><tr><td>Physically activec, n (%)</td><td>389 (22.3%)</td><td>87 (14.5%)</td><td><0.001</td><td>340 (21.8%)</td><td>136 (17.3%)</td><td>0.010</td></tr><tr><td>Current smoker, n (%)</td><td>267 (15.3%)</td><td>83 (13.8%)</td><td>0.363</td><td>184 (11.8%)</td><td>166 (21.0%)</td><td><0.001</td></tr><tr><td>Alcohol use ≥1 glass/week, n (%)</td><td>1286 (73.6%)</td><td>360 (59.9%)</td><td><0.001</td><td>1135 (72.8%)</td><td>510 (64.8%)</td><td><0.001</td></tr><tr><td>Antidepressant use, n (%)</td><td>78 (4.5%)</td><td>40 (6.6%)</td><td>0.036</td><td>67 (4.3%)</td><td>51 (6.4%)</td><td>0.023</td></tr><tr><td>Time since myocardial infarction, years</td><td>4.5 ± 3.1</td><td>4.7 ± 3.4</td><td>0.110</td><td>4.5 ± 3.2</td><td>4.7 ± 3.2</td><td>0.117</td></tr><tr><td>Self-reported history of stroke, n (%)</td><td>94 (5.4%)</td><td>58 (9.7%)</td><td><0.001</td><td>84 (5.4%)</td><td>68 (8.7%)</td><td>0.003</td></tr><tr><td>Diabetesd, n (%)</td><td>93.1 (22.3%)</td><td>188 (31.1%)</td><td><0.001</td><td>375 (24.0%)</td><td>204 (25.8%)</td><td>0.334</td></tr><tr><td>Systolic blood pressure, mmHg</td><td>142.9 ± 20.5</td><td>141.6 ± 23.7</td><td>0.188</td><td>143.4 ± 20.9</td><td>140.9 ± 22.1</td><td>0.006</td></tr><tr><td colspan="7">Use of cardiovascular medicatione, n (%)</td></tr><tr><td>Antithrombotic agents</td><td>1713 (97.9%)</td><td>584 (96.5%)</td><td>0.063</td><td>1529 (97.8%)</td><td>768 (97.1%)</td><td>0.322</td></tr><tr><td>Blood pressure lowering drugs</td><td>1729 (98.8%)</td><td>591 (97.7%)</td><td>0.051</td><td>1537 (98.3%)</td><td>783 (99.0%)</td><td>0.176</td></tr><tr><td>Statins</td><td>1553 (88.7%)</td><td>513 (84.8%)</td><td>0.011</td><td>1399 (89.5%)</td><td>667 (84.3%)</td><td><0.001</td></tr><tr><td>High-sensitivity C-reactive protein, mg/L</td><td>1.42 (0.71-3.15)</td><td>3.33 (1.27-6.91)</td><td><0.001</td><td>1.01 (0.61-1.72)</td><td>5.66 (4.04-8.83)</td><td><0.001</td></tr><tr><td>Serum creatininef, mg/dl</td><td>0.96 ± 0.18</td><td>1.54 ± 0.61</td><td><0.001</td><td>1.05 ± 0.33</td><td>1.22 ± 0.56</td><td><0.001</td></tr></table>
<table><tr><td rowspan="2"></td><td colspan="3">Creatinine-Cystatin C-based eGFR, ml/min/1.73 m2</td><td colspan="3">C-reactive protein levels, mg/L</td></tr><tr><td>≥60(n = 1750)</td><td><60(n = 605)</td><td>P-value</td><td><3(n = 1564)</td><td>≥3(n = 791)</td><td>P-value</td></tr><tr><td>Serum cystatin C, mg/L</td><td>0.89 ± 0.13</td><td>1.41 ± 0.42</td><td><0.001</td><td>0.96 ± 0.24</td><td>1.15 ± 0.42</td><td><0.001</td></tr></table>
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<table><tr><td>Analyte</td><td colspan="2">Plasma</td><td colspan="2">CSF</td></tr><tr><td> </td><td>Sensitivity (pg/mL)</td><td>Inter-assay CV range (QC concentration range)</td><td>Sensitivity (pg/mL)</td><td>Inter-assay CV range (QC concentration range)</td></tr><tr><td>IL-1Ra</td><td>16</td><td>8.2 to 3.2 (360 to 10,009 pg/mL)</td><td colspan="2">Same assay as for plasma</td></tr><tr><td>IL-1&#945;</td><td>6.1</td><td>9.0 to 4.2 (25 to 366 pg/mL)</td><td>4.75</td><td>6.6 to 9.2 (20 to 800 pg/mL)</td></tr><tr><td>IL-1&#946;</td><td>1.3</td><td>10.3 to 6.3 (17.5 to 146 pg/mL)</td><td>0.48</td><td>30.3 to 10.9 (1.3 to 10.9 pg/mL)</td></tr><tr><td>IL-6</td><td>1.7</td><td>5.9 to 2 (41 to 322 pg/mL)</td><td>17</td><td>7.1 to 2.6 (213 to 1,229 pg/mL)</td></tr><tr><td>IL-8</td><td>4.7</td><td>7.9 to 16 (109 to 975 pg/mL)</td><td>17</td><td>8.9 to 15.8 (185 to 9,152 pg/mL)</td></tr><tr><td>IL-10</td><td>1.3</td><td>10.3 to 6.26 (7.5 to 146 pg/mL)</td><td>0.82</td><td>10.6 to 5.5 (5.16 to 232 pg/mL)</td></tr><tr><td>MCP-1</td><td>45</td><td>19.5 to 11.3 (207 to 1,759 pg/mL)</td><td>147</td><td>(19 to 6.5 (9,303 to 11,275 pg/mL)</td></tr><tr><td>TNF-&#945;</td><td>0.35</td><td>6.7 to 7.0 (16.8 to 159 pg/mL)</td><td>2.5</td><td>25 to 15.8 (4.3 to 28.1 pg/mL)</td></tr><tr><td>CRP</td><td>350</td><td>14.8 to 1 (9.2 to 97 mg/L)</td><td colspan="2">ND</td></tr></table>
<table><tr><td>Analyte</td><td colspan="2">Plasma</td></tr><tr><td></td><td>Sensitivity (pg/mL)</td><td>Inter-assay CV range (QC concentration range)</td></tr><tr><td>IL-1Ra</td><td>16</td><td>8.2 to 3.2 (360 to 10,009 pg/mL)</td></tr><tr><td>IL-1α</td><td>6.1</td><td>9.0 to 4.2 (25 to 366 pg/mL)</td></tr><tr><td>IL-1β</td><td>1.3</td><td>10.3 to 6.3 (17.5 to 146 pg/mL)</td></tr><tr><td>IL-6</td><td>1.7</td><td>5.9 to 2 (41 to 322 pg/mL)</td></tr><tr><td>IL-8</td><td>4.7</td><td>7.9 to 16 (109 to 975 pg/mL)</td></tr><tr><td>IL-10</td><td>1.3</td><td>10.3 to 6.26 (7.5 to 146 pg/mL)</td></tr><tr><td>MCP-1</td><td>45</td><td>19.5 to 11.3 (207 to 1,759 pg/mL)</td></tr><tr><td>TNF-α</td><td>0.35</td><td>6.7 to 7.0 (16.8 to 159 pg/mL)</td></tr><tr><td>CRP</td><td>350</td><td>14.8 to 1 (9.2 to 97 mg/L)</td></tr></table>
<table><tr><td colspan="2">CSF</td></tr><tr><td>Sensitivity (pg/mL)</td><td>Inter-assay CV range (QC concentration range)</td></tr><tr><td colspan="2">Same assay as for plasma</td></tr><tr><td>4.75</td><td>6.6 to 9.2 (20 to 800 pg/mL)</td></tr><tr><td>0.48</td><td>30.3 to 10.9 (1.3 to 10.9 pg/mL)</td></tr><tr><td>17</td><td>7.1 to 2.6 (213 to 1,229 pg/mL)</td></tr><tr><td>17</td><td>8.9 to 15.8 (185 to 9,152 pg/mL)</td></tr><tr><td>0.82</td><td>10.6 to 5.5 (5.16 to 232 pg/mL)</td></tr><tr><td>147</td><td>(19 to 6.5 (9,303 to 11,275 pg/mL)</td></tr><tr><td>2.5</td><td>25 to 15.8 (4.3 to 28.1 pg/mL)</td></tr><tr><td colspan="2">ND</td></tr></table>
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<table><tr><td rowspan="2">Age (years)</td><td colspan="2">MDI/FSIQ &lt; 85</td><td colspan="2">Externalizing Problems &#8805; 60</td><td colspan="2">Hyperactivity subscale &#8805; 60</td><td colspan="2">Behavioral Symptoms Index &#8805; 60</td></tr><tr><td><i>n</i> (%) </td><td>OR (95% CI) </td><td><i>n</i> (%) </td><td>OR (95% CI) </td><td><i>n</i> (%) </td><td>OR (95% CI) </td><td><i>n</i> (%) </td><td>OR (95% CI) </td></tr><tr><td>1</td><td>52 (18.25)</td><td>1.22 (0.51, 2.91)</td><td>&#8212;</td><td>&#8212;</td><td>&#8212;</td><td>&#8212;</td><td>&#8212;</td><td>&#8212;</td></tr><tr><td>2</td><td>78 (32.64)</td><td>0.83 (0.39, 1.78)</td><td>12 (5.00)</td><td>5.86 (2.21, 15.55)</td><td>28 (11.67)</td><td>3.06 (1.17, 7.98)</td><td>14 (5.83)</td><td>1.30 (0.44, 3.84)</td></tr><tr><td>3</td><td>51 (23.18)</td><td>1.76 (0.78, 3.99)</td><td>37 (16.30)</td><td>2.13 (0.99, 4.56)</td><td>33 (14.54)</td><td>2.68 (1.17, 6.16)</td><td>32 (14.10)</td><td>2.54 (1.08, 5.98)</td></tr><tr><td>4</td><td>&#8212;</td><td>&#8212;</td><td>17 (10.30)</td><td>1.51 (0.44, 5.21)</td><td>17 (10.30)</td><td>2.22 (0.55, 9.01)</td><td>13 (7.88)</td><td>2.02 (0.49, 8.39)</td></tr><tr><td>5</td><td>25 (13.97)</td><td>1.70 (0.36, 7.94)</td><td>17 (9.29)</td><td>2.66 (0.47, 15.06)</td><td>19 (10.38)</td><td>4.45 (1.31, 15.14)</td><td>16 (8.74)</td><td>4.80 (1.19, 19.26)</td></tr><tr><td colspan="9">Adjusted for maternal age at enrollment, race, education, marital status, maternal serum cotinine concentrations at enrollment, maternal IQ, child sex, maternal depression, household income, and HOME Inventory score.</td></tr></table>
<table><tr><td rowspan="2">Age (years)</td><td colspan="2">MDI/FSIQ < 85</td><td colspan="2">Externalizing Problems ≥ 60</td><td colspan="2">Hyperactivity subscale ≥ 60</td><td colspan="2">Behavioral Symptoms Index ≥ 60</td></tr><tr><td>n (%)</td><td>OR (95% CI)</td><td>n (%)</td><td>OR (95% CI)</td><td>n (%)</td><td>OR (95% CI)</td><td>n (%)</td><td>OR (95% CI)</td></tr><tr><td>1</td><td>52 (18.25)</td><td>1.22 (0.51, 2.91)</td><td>—</td><td>—</td><td>—</td><td>—</td><td>—</td><td>—</td></tr><tr><td>2</td><td>78 (32.64)</td><td>0.83 (0.39, 1.78)</td><td>12 (5.00)</td><td>5.86 (2.21, 15.55)</td><td>28 (11.67)</td><td>3.06 (1.17, 7.98)</td><td>14 (5.83)</td><td>1.30 (0.44, 3.84)</td></tr><tr><td>3</td><td>51 (23.18)</td><td>1.76 (0.78, 3.99)</td><td>37 (16.30)</td><td>2.13 (0.99, 4.56)</td><td>33 (14.54)</td><td>2.68 (1.17, 6.16)</td><td>32 (14.10)</td><td>2.54 (1.08, 5.98)</td></tr></table>
<table><tr><td>4</td><td>—</td><td>—</td><td>17 (10.30)</td><td>1.51 (0.44, 5.21)</td><td>17 (10.30)</td><td>2.22 (0.55, 9.01)</td><td>13 (7.88)</td><td>2.02 (0.49, 8.39)</td></tr><tr><td>5</td><td>25 (13.97)</td><td>1.70 (0.36, 7.94)</td><td>17 (9.29)</td><td>2.66 (0.47, 15.06)</td><td>19 (10.38)</td><td>4.45 (1.31, 15.14)</td><td>16 (8.74)</td><td>4.80 (1.19, 19.26)</td></tr><tr><td colspan="9">Adjusted for maternal age at enrollment, race, education, marital status, maternal serum cotinine concentrations at enrollment, maternal IQ, child sex, maternal depression, household income, and HOME Inventory score.</td></tr></table>
a573812a3d91fc4ca4ae16cfe2e70610853516f47f9655d1b3a86efdb87a099f.png
complex
<table><tr><td></td><td>Variables</td><td>Prevalence (95% CI)</td><td>Crude OR (95% CI)</td><td>Wald</td><td>Adjusted OR<sup>a</sup> (95%CI)</td><td><i>p</i> value</td></tr><tr><td rowspan="2">Locality</td><td>Urban</td><td>38.44 (35.60, 41.37)</td><td>R</td><td></td><td></td><td></td></tr><tr><td>Rural</td><td>44.04 (40.55, 47.60)</td><td>1.14 (1.00, 1.30)</td><td></td><td></td><td></td></tr><tr><td rowspan="2">Sex</td><td>Male</td><td>36.53 (33.23, 39.96)</td><td>R</td><td></td><td></td><td></td></tr><tr><td>Female</td><td>43.35 (40.31, 46.45)</td><td>1.17 (1.03, 1.34)</td><td></td><td></td><td></td></tr><tr><td rowspan="5">Ethnicity</td><td>Malay</td><td>39.76 (36.76, 42.84)</td><td>R</td><td></td><td></td><td></td></tr><tr><td>Chinese</td><td>36.09 (31.88, 40.51)</td><td>1.01 (0.85, 1.19)</td><td></td><td></td><td></td></tr><tr><td>Indian</td><td>40.74 (32.82, 49.16)</td><td>1.05 (0.80, 1.39)</td><td></td><td></td><td></td></tr><tr><td>Other <i>Bumiputera</i></td><td>56.46 (49.04, 63.61)</td><td>2.05 (1.59, 2.66)</td><td></td><td></td><td></td></tr><tr><td>Others</td><td>39.89 (24.11, 58.09)</td><td>0.76 (0.42, 1.35)</td><td></td><td></td><td></td></tr><tr><td rowspan="3">Marital status</td><td>Single</td><td>46.13 (31.71, 61.24)</td><td>R</td><td></td><td></td><td></td></tr><tr><td>Married</td><td>35.25 (32.51, 38.09)</td><td>0.75 (0.49, 1.17)</td><td></td><td></td><td></td></tr><tr><td>Widow/Widower</td><td>50.59 (46.61, 54.56)</td><td>1.33 (0.85, 2.08)</td><td></td><td></td><td></td></tr><tr><td rowspan="5">Household income</td><td>Poorest 20%</td><td>43.57 (39.48, 47.74)</td><td>1.44 (1.16, 1.78)</td><td></td><td></td><td></td></tr><tr><td>Poor 20%</td><td>40.88 (36.41, 45.50)</td><td>1.18 (0.94, 1.48)</td><td></td><td></td><td></td></tr><tr><td>Middle income</td><td>37.63 (32.29, 43.29)</td><td>1.14 (0.89, 1.45)</td><td></td><td></td><td></td></tr><tr><td>Rich 20%</td><td>36.86 (30.96, 43.18)</td><td>1.10 (0.85, 1.42)</td><td></td><td></td><td></td></tr><tr><td>Richest 20%</td><td>37.50 (32.15, 43.18)</td><td>R</td><td></td><td></td><td></td></tr><tr><td rowspan="4">Education level</td><td>No formal education</td><td>56.68 (51.89, 61.15)</td><td>3.90 (2.71, 5.61)</td><td>12.83</td><td>2.81 (1.60, 4.96)</td><td>&lt;0.001</td></tr><tr><td>Completed Primary Education</td><td>40.87 (37.83, 43.99)</td><td>2.06 (1.45, 2.92)</td><td>4.25</td><td>1.62 (1.02, 2.55)</td><td>0.28</td></tr><tr><td>Completed Secondary Education</td><td>29.41 (25.35, 33.82)</td><td>1.28 (0.89, 1.85)</td><td>0.00</td><td>0.99 (0.62, 1.61)</td><td>0.99</td></tr><tr><td>Completed Tertiary Education</td><td>18.73 (12.96, 26.30)</td><td>R</td><td></td><td>R</td><td></td></tr><tr><td rowspan="2">Diabetes mellitus</td><td>Yes</td><td>43.33 (39.81, 46.82)</td><td>1.24 (1.08, 1.42)</td><td></td><td></td><td></td></tr><tr><td>No</td><td>38.02 (35.14, 40.99)</td><td>R</td><td></td><td></td><td></td></tr><tr><td rowspan="2">Hypertension</td><td>Yes</td><td>42.34 (39.60,45.13)</td><td>1.21 (1.05, 1.40)</td><td></td><td></td><td></td></tr><tr><td>No</td><td>34.86 (31.13, 38.58)</td><td>R</td><td></td><td></td><td></td></tr><tr><td rowspan="2">Hypercholesterolemia</td><td>Yes</td><td>39.87 (37.19,42.61)</td><td>1.20 (1.05, 1.38)</td><td></td><td></td><td></td></tr><tr><td>No</td><td></td><td>R</td><td></td><td></td><td></td></tr><tr><td rowspan="4">Body mass index</td><td>Normal</td><td>36.48 (33.11, 40.00)</td><td>R</td><td></td><td></td><td></td></tr><tr><td>Underweight</td><td>55.00 (44.52, 65.07)</td><td>1.98 (1.46, 2.69)</td><td></td><td></td><td></td></tr><tr><td>Overweight</td><td>35.15 (31.15, 39.47)</td><td>0.90 (0.76, 1.05)</td><td></td><td></td><td></td></tr><tr><td>Obese</td><td>32.58 (27.78, 37.79)</td><td>0.92 (0.75, 1.13)</td><td></td><td></td><td></td></tr><tr><td rowspan="2">Mental health problems</td><td>Yes</td><td>34.38 (27.91,4.48)</td><td>1.69 (1.32, 2.15)</td><td>14.01</td><td>1.68 (1.28, 2.20)</td><td>&lt;0.001</td></tr><tr><td>No</td><td>28.42 (24.74, 32.42)</td><td>R</td><td></td><td>R</td><td></td></tr><tr><td rowspan="2">Physical inactivity</td><td>Yes</td><td>53.07 (49.71,56.40)</td><td>2.98 (2.60, 3.42)</td><td>28.98</td><td>1.94 (1.52, 2.47)</td><td>&lt;0.001</td></tr><tr><td>No</td><td>27.54 (24.77, 30.49)</td><td>R</td><td></td><td>R</td><td></td></tr><tr><td rowspan="2">Current smoker</td><td>Yes</td><td>33.47 (28.07,39.35)</td><td>0.72 (0.59, 0.87)</td><td>4.65</td><td>0.68 (0.48, 0.97)</td><td>0.03</td></tr><tr><td>No</td><td>40.98 (38.48, 43.52)</td><td>R</td><td></td><td>R</td><td></td></tr><tr><td rowspan="2">Current drinker</td><td>Yes</td><td>23.00 (15.02,33.54)</td><td>0.39 (0.24, 0.64)</td><td></td><td></td><td></td></tr><tr><td>No</td><td>40.67 (38.35, 43.04)</td><td>R</td><td></td><td></td><td></td></tr></table>
<table><tr><td></td><td>Variables</td><td>Prevalence (95% CI)</td><td>Crude OR (95% CI)</td><td>Wald</td><td>Adjusted ORa (95%CI)</td><td>p value</td></tr><tr><td rowspan="2">Locality</td><td>Urban</td><td>38.44 (35.60, 41.37)</td><td>R</td><td></td><td></td><td></td></tr><tr><td>Rural</td><td>44.04 (40.55, 47.60)</td><td>1.14 (1.00, 1.30)</td><td></td><td></td><td></td></tr><tr><td rowspan="2">Sex</td><td>Male</td><td>36.53 (33.23, 39.96)</td><td>R</td><td></td><td></td><td></td></tr><tr><td>Female</td><td>43.35 (40.31, 46.45)</td><td>1.17 (1.03, 1.34)</td><td></td><td></td><td></td></tr><tr><td rowspan="2">Ethnicity</td><td>Malay</td><td>39.76 (36.76, 42.84)</td><td>R</td><td></td><td></td><td></td></tr><tr><td>Chinese</td><td>36.09 (31.88, 40.51)</td><td>1.01 (0.85, 1.19)</td><td></td><td></td><td></td></tr></table>
<table><tr><td rowspan="3">Ethnicity</td><td>Indian</td><td>40.74 (32.82, 49.16)</td><td>1.05 (0.80, 1.39)</td><td></td><td></td><td></td></tr><tr><td>Other Bumiputera</td><td>56.46 (49.04, 63.61)</td><td>2.05 (1.59, 2.66)</td><td></td><td></td><td></td></tr><tr><td>Others</td><td>39.89 (24.11, 58.09)</td><td>0.76 (0.42, 1.35)</td><td></td><td></td><td></td></tr><tr><td rowspan="3">Marital status</td><td>Single</td><td>46.13 (31.71, 61.24)</td><td>R</td><td></td><td></td><td></td></tr><tr><td>Married</td><td>35.25 (32.51, 38.09)</td><td>0.75 (0.49, 1.17)</td><td></td><td></td><td></td></tr><tr><td>Widow/Widower</td><td>50.59 (46.61, 54.56)</td><td>1.33 (0.85, 2.08)</td><td></td><td></td><td></td></tr><tr><td rowspan="5">Household income</td><td>Poorest 20%</td><td>43.57 (39.48, 47.74)</td><td>1.44 (1.16, 1.78)</td><td></td><td></td><td></td></tr><tr><td>Poor 20%</td><td>40.88 (36.41, 45.50)</td><td>1.18 (0.94, 1.48)</td><td></td><td></td><td></td></tr><tr><td>Middle income</td><td>37.63 (32.29, 43.29)</td><td>1.14 (0.89, 1.45)</td><td></td><td></td><td></td></tr><tr><td>Rich 20%</td><td>36.86 (30.96, 43.18)</td><td>1.10 (0.85, 1.42)</td><td></td><td></td><td></td></tr><tr><td>Richest 20%</td><td>37.50 (32.15, 43.18)</td><td>R</td><td></td><td></td><td></td></tr><tr><td rowspan="4">Education level</td><td>No formal education</td><td>56.68 (51.89, 61.15)</td><td>3.90 (2.71, 5.61)</td><td>12.83</td><td>2.81 (1.60, 4.96)</td><td><0.001</td></tr><tr><td>Completed Primary Education</td><td>40.87 (37.83, 43.99)</td><td>2.06 (1.45, 2.92)</td><td>4.25</td><td>1.62 (1.02, 2.55)</td><td>0.28</td></tr><tr><td>Completed Secondary Education</td><td>29.41 (25.35, 33.82)</td><td>1.28 (0.89, 1.85)</td><td>0.00</td><td>0.99 (0.62, 1.61)</td><td>0.99</td></tr><tr><td>Completed Tertiary Education</td><td>18.73 (12.96, 26.30)</td><td>R</td><td></td><td>R</td><td></td></tr><tr><td rowspan="2">Diabetes mellitus</td><td>Yes</td><td>43.33 (39.81, 46.82)</td><td>1.24 (1.08, 1.42)</td><td></td><td></td><td></td></tr><tr><td>No</td><td>38.02 (35.14, 40.99)</td><td>R</td><td></td><td></td><td></td></tr><tr><td rowspan="2">Hypertension</td><td>Yes</td><td>42.34 (39.60,45.13)</td><td>1.21 (1.05, 1.40)</td><td></td><td></td><td></td></tr><tr><td>No</td><td>34.86 (31.13, 38.58)</td><td>R</td><td></td><td></td><td></td></tr><tr><td rowspan="2">Hypercholesterolemia</td><td>Yes</td><td>39.87 (37.19,42.61)</td><td>1.20 (1.05, 1.38)</td><td></td><td></td><td></td></tr><tr><td>No</td><td></td><td>R</td><td></td><td></td><td></td></tr><tr><td rowspan="4">Body mass index</td><td>Normal</td><td>36.48 (33.11, 40.00)</td><td>R</td><td></td><td></td><td></td></tr><tr><td>Underweight</td><td>55.00 (44.52, 65.07)</td><td>1.98 (1.46, 2.69)</td><td></td><td></td><td></td></tr><tr><td>Overweight</td><td>35.15 (31.15, 39.47)</td><td>0.90 (0.76, 1.05)</td><td></td><td></td><td></td></tr><tr><td>Obese</td><td>32.58 (27.78, 37.79)</td><td>0.92 (0.75, 1.13)</td><td></td><td></td><td></td></tr><tr><td rowspan="2">Mental health problems</td><td>Yes</td><td>34.38 (27.91,4.48)</td><td>1.69 (1.32, 2.15)</td><td>14.01</td><td>1.68 (1.28, 2.20)</td><td><0.001</td></tr><tr><td>No</td><td>28.42 (24.74, 32.42)</td><td>R</td><td></td><td>R</td><td></td></tr><tr><td rowspan="2">Physical inactivity</td><td>Yes</td><td>53.07 (49.71,56.40)</td><td>2.98 (2.60, 3.42)</td><td>28.98</td><td>1.94 (1.52, 2.47)</td><td><0.001</td></tr><tr><td>No</td><td>27.54 (24.77, 30.49)</td><td>R</td><td></td><td>R</td><td></td></tr><tr><td rowspan="2">Current smoker</td><td>Yes</td><td>33.47 (28.07,39.35)</td><td>0.72 (0.59, 0.87)</td><td>4.65</td><td>0.68 (0.48, 0.97)</td><td>0.03</td></tr><tr><td>No</td><td>40.98 (38.48, 43.52)</td><td>R</td><td></td><td>R</td><td></td></tr><tr><td rowspan="2">Current drinker</td><td>Yes</td><td>23.00 (15.02,33.54)</td><td>0.39 (0.24, 0.64)</td><td></td><td></td><td></td></tr><tr><td>No</td><td>40.67 (38.35, 43.04)</td><td>R</td><td></td><td></td><td></td></tr></table>
1af9eb20043a38f00c3b6441d636f7fbb2d8ad5f26987eebf6f12cde828418e4.png
simple
<table><tr><td>SSRMarker</td><td>Motif</td><td>SSR Location</td><td>LG</td><td><i>n</i><sub><i>B</i></sub></td><td><i>n</i><sub><i>F</i></sub></td><td><i>n</i><sub><i>H</i></sub></td><td><i>n</i><sub><i>N</i></sub></td><td><i>n</i><sub><i>L</i></sub></td><td><i>h</i><sub><i>B</i></sub></td><td><i>h</i><sub><i>F</i></sub></td><td><i>h</i><sub><i>H</i></sub></td><td><i>h</i><sub><i>N</i></sub></td><td><i>h</i><sub><i>L</i></sub></td></tr><tr><td>IM27</td><td>(AAG)12</td><td>5' UTR</td><td>18</td><td>2</td><td>1</td><td>1</td><td>1</td><td>4</td><td>0.24</td><td>0.00</td><td>0.00</td><td>0.00</td><td>0.64</td></tr><tr><td>IM55</td><td>(GAA)9</td><td>CDS</td><td>1</td><td>6</td><td>7</td><td>4</td><td>1</td><td>10</td><td>0.76</td><td>0.83</td><td>0.68</td><td>0.00</td><td>0.82</td></tr><tr><td>IM61</td><td>(AGC)7</td><td>CDS</td><td>4</td><td>5</td><td>3</td><td>2</td><td>3</td><td>8</td><td>0.71</td><td>0.40</td><td>0.49</td><td>0.36</td><td>0.69</td></tr><tr><td>IM93</td><td>(ACC)8</td><td>CDS</td><td>9</td><td>6</td><td>2</td><td>2</td><td>2</td><td>6</td><td>0.76</td><td>0.38</td><td>0.28</td><td>0.13</td><td>0.72</td></tr><tr><td>IM95</td><td>(AAG)8</td><td>5' UTR</td><td>17</td><td>6</td><td>1</td><td>3</td><td>3</td><td>11</td><td>0.80</td><td>0.00</td><td>0.50</td><td>0.65</td><td>0.82</td></tr><tr><td>IM123</td><td>(TCT)10</td><td>CDS</td><td>3</td><td>7</td><td>4</td><td>2</td><td>5</td><td>8</td><td>0.83</td><td>0.65</td><td>0.50</td><td>0.61</td><td>0.81</td></tr><tr><td>IM144</td><td>(CAG)6</td><td>CDS</td><td>3</td><td>5</td><td>1</td><td>2</td><td>2</td><td>5</td><td>0.67</td><td>0.00</td><td>0.49</td><td>0.41</td><td>0.64</td></tr><tr><td>IM146</td><td>(ACG)6</td><td>CDS</td><td>5</td><td>4</td><td>2</td><td>2</td><td>4</td><td>6</td><td>0.72</td><td>0.15</td><td>0.38</td><td>0.53</td><td>0.77</td></tr><tr><td>IM152</td><td>(CTA)6</td><td>CDS</td><td>6</td><td>4</td><td>3</td><td>2</td><td>2</td><td>5</td><td>0.37</td><td>0.57</td><td>0.28</td><td>0.34</td><td>0.64</td></tr><tr><td>IM156</td><td>(GAG)7</td><td>CDS</td><td>4</td><td>4</td><td>3</td><td>2</td><td>1</td><td>6</td><td>0.62</td><td>0.29</td><td>0.15</td><td>0.00</td><td>0.36</td></tr><tr><td>IM164</td><td>(AGC)6</td><td>CDS</td><td>12</td><td>2</td><td>2</td><td>3</td><td>4</td><td>7</td><td>0.46</td><td>0.44</td><td>0.57</td><td>0.66</td><td>0.82</td></tr><tr><td>IM165</td><td>(CAG)6</td><td>3' UTR</td><td>5</td><td>3</td><td>1</td><td>3</td><td>2</td><td>5</td><td>0.64</td><td>0.00</td><td>0.57</td><td>0.24</td><td>0.72</td></tr><tr><td>IM196</td><td>(AAG)7</td><td>CDS</td><td>10</td><td>6</td><td>5</td><td>3</td><td>7</td><td>16</td><td>0.68</td><td>0.72</td><td>0.54</td><td>0.83</td><td>0.90</td></tr><tr><td>IM200</td><td>(GAA)23</td><td>CDS</td><td>1</td><td>9</td><td>4</td><td>2</td><td>3</td><td>10</td><td>0.87</td><td>0.51</td><td>0.28</td><td>0.44</td><td>0.77</td></tr><tr><td>IM203</td><td>(CTT)7</td><td>5' UTR</td><td>13</td><td>7</td><td>2</td><td>3</td><td>3</td><td>9</td><td>0.80</td><td>0.50</td><td>0.40</td><td>0.60</td><td>0.75</td></tr><tr><td>IM234</td><td>(GCA)7</td><td>CDS</td><td>2</td><td>3</td><td>1</td><td>4</td><td>5</td><td>8</td><td>0.50</td><td>0.00</td><td>0.71</td><td>0.67</td><td>0.70</td></tr><tr><td>IM235</td><td>(TGC)6</td><td>3' UTR</td><td>12</td><td>4</td><td>2</td><td>4</td><td>3</td><td>10</td><td>0.66</td><td>0.44</td><td>0.58</td><td>0.62</td><td>0.83</td></tr><tr><td>IM283</td><td>(CCT)8</td><td>CDS</td><td>21</td><td>2</td><td>2</td><td>2</td><td>1</td><td>4</td><td>0.13</td><td>0.15</td><td>0.15</td><td>0.00</td><td>0.55</td></tr><tr><td>IM299</td><td>(TA)6</td><td>3' UTR</td><td>19</td><td>4</td><td>4</td><td>3</td><td>4</td><td>7</td><td>0.66</td><td>0.51</td><td>0.57</td><td>0.73</td><td>0.80</td></tr><tr><td>IM303</td><td>(TCC)6</td><td>5' UTR</td><td>16</td><td>6</td><td>5</td><td>2</td><td>1</td><td>10</td><td>0.80</td><td>0.69</td><td>0.15</td><td>0.00</td><td>0.77</td></tr><tr><td>IM319</td><td>(GAG)7</td><td>5' UTR</td><td>5</td><td>9</td><td>1</td><td>3</td><td>3</td><td>11</td><td>0.87</td><td>0.00</td><td>0.29</td><td>0.52</td><td>0.82</td></tr><tr><td>IM327</td><td>(GA)12</td><td>5' UTR</td><td>20</td><td>6</td><td>7</td><td>4</td><td>4</td><td>13</td><td>0.78</td><td>0.79</td><td>0.60</td><td>0.70</td><td>0.88</td></tr><tr><td>IM341</td><td>(GAG)6</td><td>5' UTR</td><td>12</td><td>3</td><td>1</td><td>3</td><td>1</td><td>7</td><td>0.50</td><td>0.00</td><td>0.65</td><td>0.00</td><td>0.69</td></tr><tr><td>IM348</td><td>(AGG)7</td><td>CDS</td><td>2</td><td>7</td><td>3</td><td>8</td><td>4</td><td>11</td><td>0.70</td><td>0.49</td><td>0.85</td><td>0.46</td><td>0.77</td></tr><tr><td>IM364</td><td>(CTT)6</td><td>CDS</td><td>9</td><td>9</td><td>4</td><td>2</td><td>2</td><td>10</td><td>0.87</td><td>0.65</td><td>0.15</td><td>0.24</td><td>0.73</td></tr><tr><td>IM377</td><td>(ATT)6</td><td>5' UTR</td><td>7</td><td>3</td><td>2</td><td>1</td><td>2</td><td>7</td><td>0.26</td><td>0.44</td><td>0.00</td><td>0.41</td><td>0.78</td></tr><tr><td>IM378</td><td>(TTC)9</td><td>5' UTR</td><td>6</td><td>3</td><td>3</td><td>2</td><td>2</td><td>6</td><td>0.50</td><td>0.57</td><td>0.15</td><td>0.50</td><td>0.78</td></tr><tr><td>IM389</td><td>(CTT)8</td><td>CDS</td><td>14</td><td>8</td><td>3</td><td>1</td><td>4</td><td>9</td><td>0.84</td><td>0.29</td><td>0.00</td><td>0.66</td><td>0.70</td></tr><tr><td>IM391</td><td>(TTC)12</td><td>5' UTR</td><td>15</td><td>6</td><td>7</td><td>2</td><td>5</td><td>12</td><td>0.69</td><td>0.83</td><td>0.15</td><td>0.73</td><td>0.87</td></tr><tr><td>IM395</td><td>(TC)8</td><td>3' UTR</td><td>15</td><td>3</td><td>3</td><td>3</td><td>4</td><td>7</td><td>0.57</td><td>0.61</td><td>0.57</td><td>0.53</td><td>0.80</td></tr><tr><td>IM402</td><td>(CTT)10</td><td>5' UTR</td><td>13</td><td>7</td><td>2</td><td>2</td><td>3</td><td>9</td><td>0.82</td><td>0.49</td><td>0.15</td><td>0.60</td><td>0.78</td></tr><tr><td>IM426</td><td>(TCT)7</td><td>5' UTR</td><td>4</td><td>6</td><td>4</td><td>2</td><td>4</td><td>11</td><td>0.76</td><td>0.71</td><td>0.38</td><td>0.62</td><td>0.85</td></tr><tr><td>IM429</td><td>(AGA)8</td><td>5' UTR</td><td>14</td><td>3</td><td>3</td><td>3</td><td>2</td><td>8</td><td>0.44</td><td>0.40</td><td>0.40</td><td>0.34</td><td>0.75</td></tr><tr><td>IM442</td><td>(GA)7</td><td>5' UTR</td><td>16</td><td>2</td><td>1</td><td>1</td><td>2</td><td>2</td><td>0.34</td><td>0.00</td><td>0.00</td><td>0.46</td><td>0.47</td></tr><tr><td>IM450</td><td>(CAG)7</td><td>CDS</td><td>2</td><td>7</td><td>2</td><td>5</td><td>4</td><td>10</td><td>0.74</td><td>0.28</td><td>0.53</td><td>0.64</td><td>0.70</td></tr><tr><td>IM460</td><td>(GA)7</td><td>5' UTR</td><td>8</td><td>7</td><td>2</td><td>3</td><td>4</td><td>13</td><td>0.83</td><td>0.28</td><td>0.54</td><td>0.66</td><td>0.85</td></tr><tr><td>IM486</td><td>(AGC)7</td><td>CDS</td><td>11</td><td>3</td><td>5</td><td>4</td><td>7</td><td>12</td><td>0.57</td><td>0.72</td><td>0.68</td><td>0.80</td><td>0.89</td></tr><tr><td>IM501</td><td>(AG)13</td><td>5' UTR</td><td>7</td><td>6</td><td>3</td><td>5</td><td>4</td><td>14</td><td>0.76</td><td>0.40</td><td>0.72</td><td>0.61</td><td>0.88</td></tr><tr><td>IM503</td><td>(CT)12</td><td>5' UTR</td><td>10</td><td>7</td><td>6</td><td>5</td><td>7</td><td>18</td><td>0.82</td><td>0.82</td><td>0.68</td><td>0.76</td><td>0.89</td></tr><tr><td>IM526</td><td>(CAC)6</td><td>CDS</td><td>11</td><td>6</td><td>3</td><td>5</td><td>3</td><td>9</td><td>0.73</td><td>0.40</td><td>0.76</td><td>0.52</td><td>0.83</td></tr><tr><td>Mean</td><td></td><td></td><td></td><td>5.2</td><td>3.0</td><td>2.9</td><td>3.2</td><td>8.9</td><td>0.65</td><td>0.41</td><td>0.41</td><td>0.47</td><td>0.76</td></tr></table>
<table><tr><td>SSRMarker</td><td>Motif</td><td>SSR Location</td><td>LG</td><td>nB</td><td>nF</td><td>nH</td><td>nN</td><td>nL</td><td>hB</td><td>hF</td><td>hH</td><td>hN</td><td>hL</td></tr><tr><td>IM27</td><td>(AAG)12</td><td>5' UTR</td><td>18</td><td>2</td><td>1</td><td>1</td><td>1</td><td>4</td><td>0.24</td><td>0.00</td><td>0.00</td><td>0.00</td><td>0.64</td></tr><tr><td>IM55</td><td>(GAA)9</td><td>CDS</td><td>1</td><td>6</td><td>7</td><td>4</td><td>1</td><td>10</td><td>0.76</td><td>0.83</td><td>0.68</td><td>0.00</td><td>0.82</td></tr><tr><td>IM61</td><td>(AGC)7</td><td>CDS</td><td>4</td><td>5</td><td>3</td><td>2</td><td>3</td><td>8</td><td>0.71</td><td>0.40</td><td>0.49</td><td>0.36</td><td>0.69</td></tr><tr><td>IM93</td><td>(ACC)8</td><td>CDS</td><td>9</td><td>6</td><td>2</td><td>2</td><td>2</td><td>6</td><td>0.76</td><td>0.38</td><td>0.28</td><td>0.13</td><td>0.72</td></tr><tr><td>IM95</td><td>(AAG)8</td><td>5' UTR</td><td>17</td><td>6</td><td>1</td><td>3</td><td>3</td><td>11</td><td>0.80</td><td>0.00</td><td>0.50</td><td>0.65</td><td>0.82</td></tr><tr><td>IM123</td><td>(TCT)10</td><td>CDS</td><td>3</td><td>7</td><td>4</td><td>2</td><td>5</td><td>8</td><td>0.83</td><td>0.65</td><td>0.50</td><td>0.61</td><td>0.81</td></tr><tr><td>IM144</td><td>(CAG)6</td><td>CDS</td><td>3</td><td>5</td><td>1</td><td>2</td><td>2</td><td>5</td><td>0.67</td><td>0.00</td><td>0.49</td><td>0.41</td><td>0.64</td></tr><tr><td>IM146</td><td>(ACG)6</td><td>CDS</td><td>5</td><td>4</td><td>2</td><td>2</td><td>4</td><td>6</td><td>0.72</td><td>0.15</td><td>0.38</td><td>0.53</td><td>0.77</td></tr><tr><td>IM152</td><td>(CTA)6</td><td>CDS</td><td>6</td><td>4</td><td>3</td><td>2</td><td>2</td><td>5</td><td>0.37</td><td>0.57</td><td>0.28</td><td>0.34</td><td>0.64</td></tr><tr><td>IM156</td><td>(GAG)7</td><td>CDS</td><td>4</td><td>4</td><td>3</td><td>2</td><td>1</td><td>6</td><td>0.62</td><td>0.29</td><td>0.15</td><td>0.00</td><td>0.36</td></tr><tr><td>IM164</td><td>(AGC)6</td><td>CDS</td><td>12</td><td>2</td><td>2</td><td>3</td><td>4</td><td>7</td><td>0.46</td><td>0.44</td><td>0.57</td><td>0.66</td><td>0.82</td></tr><tr><td>IM165</td><td>(CAG)6</td><td>3' UTR</td><td>5</td><td>3</td><td>1</td><td>3</td><td>2</td><td>5</td><td>0.64</td><td>0.00</td><td>0.57</td><td>0.24</td><td>0.72</td></tr><tr><td>IM196</td><td>(AAG)7</td><td>CDS</td><td>10</td><td>6</td><td>5</td><td>3</td><td>7</td><td>16</td><td>0.68</td><td>0.72</td><td>0.54</td><td>0.83</td><td>0.90</td></tr><tr><td>IM200</td><td>(GAA)23</td><td>CDS</td><td>1</td><td>9</td><td>4</td><td>2</td><td>3</td><td>10</td><td>0.87</td><td>0.51</td><td>0.28</td><td>0.44</td><td>0.77</td></tr><tr><td>IM203</td><td>(CTT)7</td><td>5' UTR</td><td>13</td><td>7</td><td>2</td><td>3</td><td>3</td><td>9</td><td>0.80</td><td>0.50</td><td>0.40</td><td>0.60</td><td>0.75</td></tr><tr><td>IM234</td><td>(GCA)7</td><td>CDS</td><td>2</td><td>3</td><td>1</td><td>4</td><td>5</td><td>8</td><td>0.50</td><td>0.00</td><td>0.71</td><td>0.67</td><td>0.70</td></tr><tr><td>IM235</td><td>(TGC)6</td><td>3' UTR</td><td>12</td><td>4</td><td>2</td><td>4</td><td>3</td><td>10</td><td>0.66</td><td>0.44</td><td>0.58</td><td>0.62</td><td>0.83</td></tr><tr><td>IM283</td><td>(CCT)8</td><td>CDS</td><td>21</td><td>2</td><td>2</td><td>2</td><td>1</td><td>4</td><td>0.13</td><td>0.15</td><td>0.15</td><td>0.00</td><td>0.55</td></tr><tr><td>IM299</td><td>(TA)6</td><td>3' UTR</td><td>19</td><td>4</td><td>4</td><td>3</td><td>4</td><td>7</td><td>0.66</td><td>0.51</td><td>0.57</td><td>0.73</td><td>0.80</td></tr><tr><td>IM303</td><td>(TCC)6</td><td>5' UTR</td><td>16</td><td>6</td><td>5</td><td>2</td><td>1</td><td>10</td><td>0.80</td><td>0.69</td><td>0.15</td><td>0.00</td><td>0.77</td></tr><tr><td>IM319</td><td>(GAG)7</td><td>5' UTR</td><td>5</td><td>9</td><td>1</td><td>3</td><td>3</td><td>11</td><td>0.87</td><td>0.00</td><td>0.29</td><td>0.52</td><td>0.82</td></tr><tr><td>IM327</td><td>(GA)12</td><td>5' UTR</td><td>20</td><td>6</td><td>7</td><td>4</td><td>4</td><td>13</td><td>0.78</td><td>0.79</td><td>0.60</td><td>0.70</td><td>0.88</td></tr><tr><td>IM341</td><td>(GAG)6</td><td>5' UTR</td><td>12</td><td>3</td><td>1</td><td>3</td><td>1</td><td>7</td><td>0.50</td><td>0.00</td><td>0.65</td><td>0.00</td><td>0.69</td></tr><tr><td>IM348</td><td>(AGG)7</td><td>CDS</td><td>2</td><td>7</td><td>3</td><td>8</td><td>4</td><td>11</td><td>0.70</td><td>0.49</td><td>0.85</td><td>0.46</td><td>0.77</td></tr><tr><td>IM364</td><td>(CTT)6</td><td>CDS</td><td>9</td><td>9</td><td>4</td><td>2</td><td>2</td><td>10</td><td>0.87</td><td>0.65</td><td>0.15</td><td>0.24</td><td>0.73</td></tr><tr><td>IM377</td><td>(ATT)6</td><td>5' UTR</td><td>7</td><td>3</td><td>2</td><td>1</td><td>2</td><td>7</td><td>0.26</td><td>0.44</td><td>0.00</td><td>0.41</td><td>0.78</td></tr><tr><td>IM378</td><td>(TTC)9</td><td>5' UTR</td><td>6</td><td>3</td><td>3</td><td>2</td><td>2</td><td>6</td><td>0.50</td><td>0.57</td><td>0.15</td><td>0.50</td><td>0.78</td></tr><tr><td>IM389</td><td>(CTT)8</td><td>CDS</td><td>14</td><td>8</td><td>3</td><td>1</td><td>4</td><td>9</td><td>0.84</td><td>0.29</td><td>0.00</td><td>0.66</td><td>0.70</td></tr><tr><td>IM391</td><td>(TTC)12</td><td>5' UTR</td><td>15</td><td>6</td><td>7</td><td>2</td><td>5</td><td>12</td><td>0.69</td><td>0.83</td><td>0.15</td><td>0.73</td><td>0.87</td></tr><tr><td>IM395</td><td>(TC)8</td><td>3' UTR</td><td>15</td><td>3</td><td>3</td><td>3</td><td>4</td><td>7</td><td>0.57</td><td>0.61</td><td>0.57</td><td>0.53</td><td>0.80</td></tr><tr><td>IM402</td><td>(CTT)10</td><td>5' UTR</td><td>13</td><td>7</td><td>2</td><td>2</td><td>3</td><td>9</td><td>0.82</td><td>0.49</td><td>0.15</td><td>0.60</td><td>0.78</td></tr><tr><td>IM426</td><td>(TCT)7</td><td>5' UTR</td><td>4</td><td>6</td><td>4</td><td>2</td><td>4</td><td>11</td><td>0.76</td><td>0.71</td><td>0.38</td><td>0.62</td><td>0.85</td></tr><tr><td>IM429</td><td>(AGA)8</td><td>5' UTR</td><td>14</td><td>3</td><td>3</td><td>3</td><td>2</td><td>8</td><td>0.44</td><td>0.40</td><td>0.40</td><td>0.34</td><td>0.75</td></tr><tr><td>IM442</td><td>(GA)7</td><td>5' UTR</td><td>16</td><td>2</td><td>1</td><td>1</td><td>2</td><td>2</td><td>0.34</td><td>0.00</td><td>0.00</td><td>0.46</td><td>0.47</td></tr><tr><td>IM450</td><td>(CAG)7</td><td>CDS</td><td>2</td><td>7</td><td>2</td><td>5</td><td>4</td><td>10</td><td>0.74</td><td>0.28</td><td>0.53</td><td>0.64</td><td>0.70</td></tr><tr><td>IM460</td><td>(GA)7</td><td>5' UTR</td><td>8</td><td>7</td><td>2</td><td>3</td><td>4</td><td>13</td><td>0.83</td><td>0.28</td><td>0.54</td><td>0.66</td><td>0.85</td></tr><tr><td>IM486</td><td>(AGC)7</td><td>CDS</td><td>11</td><td>3</td><td>5</td><td>4</td><td>7</td><td>12</td><td>0.57</td><td>0.72</td><td>0.68</td><td>0.80</td><td>0.89</td></tr><tr><td>IM501</td><td>(AG)13</td><td>5' UTR</td><td>7</td><td>6</td><td>3</td><td>5</td><td>4</td><td>14</td><td>0.76</td><td>0.40</td><td>0.72</td><td>0.61</td><td>0.88</td></tr></table>
<table><tr><td>SSRMarker</td><td>Motif</td><td>SSR Location</td><td>LG</td><td>nB</td><td>nF</td><td>nH</td><td>nN</td><td>nL</td><td>hB</td><td>hF</td><td>hH</td><td>hN</td><td>hL</td></tr><tr><td>IM503</td><td>(CT)12</td><td>5' UTR</td><td>10</td><td>7</td><td>6</td><td>5</td><td>7</td><td>18</td><td>0.82</td><td>0.82</td><td>0.68</td><td>0.76</td><td>0.89</td></tr><tr><td>IM526</td><td>(CAC)6</td><td>CDS</td><td>11</td><td>6</td><td>3</td><td>5</td><td>3</td><td>9</td><td>0.73</td><td>0.40</td><td>0.76</td><td>0.52</td><td>0.83</td></tr><tr><td>Mean</td><td></td><td></td><td></td><td>5.2</td><td>3.0</td><td>2.9</td><td>3.2</td><td>8.9</td><td>0.65</td><td>0.41</td><td>0.41</td><td>0.47</td><td>0.76</td></tr></table>
f4b3c1b3609b06c96e3a1df28e2160395a54505bc2f48023a3d3775258f0a27f.png
complex
<table><tr><td rowspan="2">Serum samples against:</td><td rowspan="2">Clade</td><td colspan="2">HI titer (log<sub>2</sub>) against</td><td rowspan="2">HA identity*</td></tr><tr><td>TK16</td><td>Homologous antigen</td></tr><tr><td>A/chicken/Egypt/AR234-FAOF8NLQP/2014 (H5N1)</td><td>2.2.1.2</td><td>7</td><td>9</td><td>99.4/100</td></tr><tr><td>A/chicken/Egypt/0879-NLQP/2008 (H5N1)</td><td>2.2.1.1</td><td>5</td><td>10</td><td>94.7/94.2</td></tr><tr><td>A/teal/Germany/WV632/2005 (H5N1)</td><td>2.2</td><td>6</td><td>9</td><td>88.7/90.6</td></tr><tr><td>A/turkey/Germany-MV/R2472/2014 (H5N8)</td><td>2.3.4.4</td><td>2</td><td>7</td><td>88.7/90.6</td></tr><tr><td>A/Vietnam/1194/2004 (H5N1)</td><td>1</td><td>6</td><td>8</td><td>93.2/95.1</td></tr></table>
<table><tr><td rowspan="2">Serum samples against:</td><td rowspan="2">Clade</td><td colspan="2">HI titer (log2) against</td><td rowspan="2">HA identity*</td></tr><tr><td>TK16</td><td>Homologous antigen</td></tr><tr><td>A/chicken/Egypt/AR234-FAOF8NLQP/2014 (H5N1)</td><td>2.2.1.2</td><td>7</td><td>9</td><td>99.4/100</td></tr><tr><td>A/chicken/Egypt/0879-NLQP/2008 (H5N1)</td><td>2.2.1.1</td><td>5</td><td>10</td><td>94.7/94.2</td></tr></table>
<table><tr><td rowspan="2">Serum samples against:</td><td rowspan="2">Clade</td><td colspan="2">HI titer (log2) against</td><td rowspan="2">HA identity*</td></tr><tr><td>TK16</td><td>Homologous antigen</td></tr><tr><td>A/teal/Germany/WV632/2005 (H5N1)</td><td>2.2</td><td>6</td><td>9</td><td>88.7/90.6</td></tr><tr><td>A/turkey/Germany-MV/R2472/2014 (H5N8)</td><td>2.3.4.4</td><td>2</td><td>7</td><td>88.7/90.6</td></tr><tr><td>A/Vietnam/1194/2004 (H5N1)</td><td>1</td><td>6</td><td>8</td><td>93.2/95.1</td></tr></table>
a7c6f02d7b2e5b7e58efb7e2df9d0dadb1d8ed32b699c7909ff74165ec8c2252.png
complex
<table><tr><td> </td><td colspan="2"> </td><td>BMI</td><td>Age</td><td>12-month</td></tr><tr><td>DSM-5 diagnosis</td><td>N</td><td>%</td><td><i>M</i> (<i>SD</i>)</td><td><i>M</i> (<i>SD</i>)</td><td>N</td></tr><tr><td>RAN</td><td>364</td><td>16.3</td><td>16.1 (1.6)</td><td>23.2 (6.6)</td><td>102</td></tr><tr><td>ANB/P</td><td>295</td><td>13.2</td><td>16.8 (1.4)</td><td>24.3 (7.1)</td><td>67</td></tr><tr><td>BN</td><td>874</td><td>39.1</td><td>23.6 (4.3)</td><td>26.4 (8.0)</td><td>219</td></tr><tr><td>BED</td><td>124</td><td>5.6</td><td>31.4 (7.7)</td><td>30.2 (10.2)</td><td>22</td></tr><tr><td>AAN</td><td>310</td><td>13.9</td><td>22.7 (4.5)</td><td>26.0 (7.0)</td><td>69</td></tr><tr><td>Sub BED</td><td>11</td><td>0.5</td><td>30.2 (7.6)</td><td>34.4 (13.2)</td><td>-</td></tr><tr><td>PD</td><td>184</td><td>8.2</td><td>21.9 (3.5)</td><td>25.4 (7.9)</td><td>39</td></tr><tr><td>UFED</td><td>71</td><td>3.2</td><td>19.9 (6.7)</td><td>26.1 (9.1)</td><td>12</td></tr></table>
<table><tr><td></td><td colspan="2"></td><td>BMI</td><td>Age</td><td>12-month</td></tr><tr><td>DSM-5 diagnosis</td><td>N</td><td>%</td><td>M (SD)</td><td>M (SD)</td><td>N</td></tr><tr><td>RAN</td><td>364</td><td>16.3</td><td>16.1 (1.6)</td><td>23.2 (6.6)</td><td>102</td></tr><tr><td>ANB/P</td><td>295</td><td>13.2</td><td>16.8 (1.4)</td><td>24.3 (7.1)</td><td>67</td></tr><tr><td>BN</td><td>874</td><td>39.1</td><td>23.6 (4.3)</td><td>26.4 (8.0)</td><td>219</td></tr><tr><td>BED</td><td>124</td><td>5.6</td><td>31.4 (7.7)</td><td>30.2 (10.2)</td><td>22</td></tr><tr><td>AAN</td><td>310</td><td>13.9</td><td>22.7 (4.5)</td><td>26.0 (7.0)</td><td>69</td></tr></table>
<table><tr><td>Sub BED</td><td>11</td><td>0.5</td><td>30.2 (7.6)</td><td>34.4 (13.2)</td><td>-</td></tr><tr><td>PD</td><td>184</td><td>8.2</td><td>21.9 (3.5)</td><td>25.4 (7.9)</td><td>39</td></tr><tr><td>UFED</td><td>71</td><td>3.2</td><td>19.9 (6.7)</td><td>26.1 (9.1)</td><td>12</td></tr></table>
38b11761a70edb96ee12d5446a1c1dbcb957814107560ec4df9e8e7a9fd330c9.png
simple
<table><tr><td>Pseudo-chromosome</td><td>No. of SNPs</td><td>No. of InDels</td><td>No. of SSRs</td><td>Physical size (Mb)</td></tr><tr><td>Pseudo-chromosome 1</td><td>25,395 (941)</td><td>596 (22)</td><td>798 (30)</td><td>26.8</td></tr><tr><td>Pseudo-chromosome 2</td><td>40,350 (961)</td><td>895 (21)</td><td>1,376 (33)</td><td>42.1</td></tr><tr><td>Pseudo-chromosome 3</td><td>27,111 (1,084)</td><td>548 (22)</td><td>764 (31)</td><td>24.6</td></tr><tr><td>Pseudo-chromosome 4</td><td>20,975 (874)</td><td>552 (23)</td><td>789 (33)</td><td>24.0</td></tr><tr><td>Pseudo-chromosome 5</td><td>20,446 (786)</td><td>545 (21)</td><td>760 (29)</td><td>25.8</td></tr><tr><td>Pseudo-chromosome 6</td><td>19,016 (906)</td><td>516 (25)</td><td>584 (27)</td><td>21.3</td></tr><tr><td>Pseudo-chromosome 7</td><td>14,219 (836)</td><td>344 (20)</td><td>562 (33)</td><td>17.1</td></tr><tr><td>Pseudo-chromosome 8</td><td>11,360 (668)</td><td>452 (27)</td><td>502 (29)</td><td>17.3</td></tr><tr><td>Total</td><td>178,872 (899)</td><td>4,448 (22)</td><td>6,135 (31)</td><td>199.0</td></tr></table>
<table><tr><td>Pseudo-chromosome</td><td>No. of SNPs</td><td>No. of InDels</td><td>No. of SSRs</td><td>Physical size (Mb)</td></tr><tr><td>Pseudo-chromosome 1</td><td>25,395 (941)</td><td>596 (22)</td><td>798 (30)</td><td>26.8</td></tr><tr><td>Pseudo-chromosome 2</td><td>40,350 (961)</td><td>895 (21)</td><td>1,376 (33)</td><td>42.1</td></tr><tr><td>Pseudo-chromosome 3</td><td>27,111 (1,084)</td><td>548 (22)</td><td>764 (31)</td><td>24.6</td></tr><tr><td>Pseudo-chromosome 4</td><td>20,975 (874)</td><td>552 (23)</td><td>789 (33)</td><td>24.0</td></tr><tr><td>Pseudo-chromosome 5</td><td>20,446 (786)</td><td>545 (21)</td><td>760 (29)</td><td>25.8</td></tr></table>
<table><tr><td>Pseudo-chromosome 6</td><td>19,016 (906)</td><td>516 (25)</td><td>584 (27)</td><td>21.3</td></tr><tr><td>Pseudo-chromosome 7</td><td>14,219 (836)</td><td>344 (20)</td><td>562 (33)</td><td>17.1</td></tr><tr><td>Pseudo-chromosome 8</td><td>11,360 (668)</td><td>452 (27)</td><td>502 (29)</td><td>17.3</td></tr><tr><td>Total</td><td>178,872 (899)</td><td>4,448 (22)</td><td>6,135 (31)</td><td>199.0</td></tr></table>
50a004196def1e0b92b64464b65d59f2ca02c4816625cdf807881aa3373596ee.png
simple
<table><tr><td>Parameters</td><td>Pre-treatment</td><td>First weekpost-treatment</td><td>Second weekpost-treatment</td></tr><tr><td>Volume of ejaculate (ml)</td><td>0.30 &#177; 0.02 *</td><td>0.23 &#177; 0.02</td><td>0.15 &#177; 0.02*</td></tr><tr><td>Color of ejaculate</td><td>Milky to creamy white</td><td>Milky to creamy white</td><td>Milky to creamy white</td></tr><tr><td>Sperm motility </td><td>85% *</td><td>80%</td><td>70% *</td></tr><tr><td>Spermatozoa viability</td><td>96% *</td><td>90%</td><td>83% *</td></tr><tr><td>Sperm concentration (x 10<sup>9</sup>/ml)</td><td>428 &#177; 4.26 *</td><td>341 &#177; 6.63 *</td><td>289 &#177; 4.81*</td></tr></table>
<table><tr><td>Parameters</td><td>Pre-treatment</td><td>First weekpost-treatment</td><td>Second weekpost-treatment</td></tr><tr><td>Volume of ejaculate (ml)</td><td>0.30 ± 0.02 *</td><td>0.23 ± 0.02</td><td>0.15 ± 0.02*</td></tr><tr><td>Color of ejaculate</td><td>Milky to creamy white</td><td>Milky to creamy white</td><td>Milky to creamy white</td></tr></table>
<table><tr><td>Sperm motility</td><td>85% *</td><td>80%</td><td>70% *</td></tr><tr><td>Spermatozoa viability</td><td>96% *</td><td>90%</td><td>83% *</td></tr><tr><td>Sperm concentration (x 109/ml)</td><td>428 ± 4.26 *</td><td>341 ± 6.63 *</td><td>289 ± 4.81*</td></tr></table>
4ca2c18a1088ef058fbf7129c61af7fe7eb35c7a0eee41aecfbf73b42fc645d5.png
complex
<table><tr><td rowspan="2">Variable</td><td colspan="2">Analysis with CCP score</td><td colspan="2">Analysis with mPS</td></tr><tr><td>Hazard ratio (95% CI)</td><td><i>P</i> value</td><td>Hazard ratio (95% CI)</td><td><i>P</i> value</td></tr><tr><td>CCP score</td><td>1.60 (1.14, 2.24)</td><td>0.006</td><td></td><td></td></tr><tr><td>mPS</td><td></td><td></td><td>1.77 (1.18, 2.66)</td><td>0.006</td></tr><tr><td>Age at diagnosis</td><td>1.03 (1.01, 1.05)</td><td>0.016</td><td>1.03 (1.01, 1.05)</td><td>0.016</td></tr><tr><td>Sex</td><td></td><td>0.343</td><td></td><td>0.342</td></tr><tr><td> Male</td><td>1</td><td></td><td>1</td><td></td></tr><tr><td> Female</td><td>0.82 (0.54, 1.25)</td><td></td><td>0.82 (0.54, 1.24)</td><td></td></tr><tr><td>Smoking status</td><td></td><td>0.676</td><td></td><td>0.675</td></tr><tr><td> Never</td><td>1</td><td></td><td>1</td><td></td></tr><tr><td> Former</td><td>1.35 (0.69, 2.95)</td><td></td><td>1.35 (0.69, 2.95)</td><td></td></tr><tr><td> Current</td><td>1.41 (0.60, 3.51)</td><td></td><td>1.41 (0.60, 3.51)</td><td></td></tr><tr><td>Surgical procedure</td><td></td><td>&lt;0.001</td><td></td><td>&lt;0.001</td></tr><tr><td> Pneumonectomy/Bilobectomy/Lobectomy</td><td>1</td><td></td><td>1</td><td></td></tr><tr><td> Segmentectomy</td><td>3.31 (1.62, 6.30)</td><td></td><td>3.31 (1.62, 6.30)</td><td></td></tr><tr><td> Wedge resection</td><td>4.65 (2.71, 7.91)</td><td></td><td>4.65 (2.71, 7.90)</td><td></td></tr><tr><td>Tumor size</td><td>1.64 (1.24, 2.14)</td><td>&lt;0.001</td><td>1.64 (1.24, 2.15)</td><td>&lt;0.001</td></tr><tr><td>Pathological stage</td><td></td><td>0.720</td><td></td><td>0.158</td></tr><tr><td> IA</td><td>1</td><td></td><td>1</td><td></td></tr><tr><td> IB</td><td>0.87 (0.39, 1.90)</td><td></td><td>0.53 (0.22, 1.28)</td><td></td></tr><tr><td>Pleural invasion</td><td></td><td>0.056</td><td></td><td>0.057</td></tr><tr><td> PLX/PL0</td><td>1</td><td></td><td>1</td><td></td></tr><tr><td> PL1</td><td>1.94 (0.91, 4.12)</td><td></td><td>1.94 (0.91, 4.12)</td><td></td></tr><tr><td> PL2</td><td>3.39 (1.15, 8.79)</td><td></td><td>3.38 (1.15, 8.76)</td><td></td></tr><tr><td>Lymphatic invasion</td><td></td><td>0.020</td><td></td><td>0.019</td></tr><tr><td> Absent</td><td>1</td><td></td><td>1</td><td></td></tr><tr><td> Present</td><td>1.73 (1.09, 2.77)</td><td></td><td>1.74 (1.10, 2.78)</td><td></td></tr><tr><td>Vascular invasion</td><td></td><td>0.089</td><td></td><td>0.091</td></tr><tr><td> Absent</td><td>1</td><td></td><td>1</td><td></td></tr><tr><td> Present</td><td>1.52 (0.94, 2.44)</td><td></td><td>1.51 (0.94, 2.44)</td><td></td></tr><tr><td>Morphological grade</td><td></td><td>0.012</td><td></td><td>0.011</td></tr><tr><td> Low</td><td>1</td><td></td><td>1</td><td></td></tr><tr><td> Intermediate</td><td>3.08 (0.92, 19.13)</td><td></td><td>3.08 (0.92, 19.13)</td><td></td></tr><tr><td> High</td><td>5.09 (1.46, 32.18)</td><td></td><td>5.10 (1.46, 32.22)</td><td></td></tr></table>
<table><tr><td rowspan="2">Variable</td><td colspan="2">Analysis with CCP score</td><td colspan="2">Analysis with mPS</td></tr><tr><td>Hazard ratio (95% CI)</td><td>P value</td><td>Hazard ratio (95% CI)</td><td>P value</td></tr><tr><td>CCP score</td><td>1.60 (1.14, 2.24)</td><td>0.006</td><td></td><td></td></tr><tr><td>mPS</td><td></td><td></td><td>1.77 (1.18, 2.66)</td><td>0.006</td></tr><tr><td>Age at diagnosis</td><td>1.03 (1.01, 1.05)</td><td>0.016</td><td>1.03 (1.01, 1.05)</td><td>0.016</td></tr><tr><td>Sex</td><td></td><td>0.343</td><td></td><td>0.342</td></tr><tr><td>Male</td><td>1</td><td></td><td>1</td><td></td></tr><tr><td>Female</td><td>0.82 (0.54, 1.25)</td><td></td><td>0.82 (0.54, 1.24)</td><td></td></tr><tr><td>Smoking status</td><td></td><td>0.676</td><td></td><td>0.675</td></tr><tr><td>Never</td><td>1</td><td></td><td>1</td><td></td></tr><tr><td>Former</td><td>1.35 (0.69, 2.95)</td><td></td><td>1.35 (0.69, 2.95)</td><td></td></tr><tr><td>Current</td><td>1.41 (0.60, 3.51)</td><td></td><td>1.41 (0.60, 3.51)</td><td></td></tr><tr><td>Surgical procedure</td><td></td><td><0.001</td><td></td><td><0.001</td></tr><tr><td>Pneumonectomy/Bilobectomy/Lobectomy</td><td>1</td><td></td><td>1</td><td></td></tr></table>
<table><tr><td rowspan="2">Variable</td><td colspan="2">Analysis with CCP score</td><td colspan="2">Analysis with mPS</td></tr><tr><td>Hazard ratio (95% CI)</td><td>P value</td><td>Hazard ratio (95% CI)</td><td>P value</td></tr><tr><td>Segmentectomy</td><td>3.31 (1.62, 6.30)</td><td></td><td>3.31 (1.62, 6.30)</td><td></td></tr><tr><td>Wedge resection</td><td>4.65 (2.71, 7.91)</td><td></td><td>4.65 (2.71, 7.90)</td><td></td></tr><tr><td>Tumor size</td><td>1.64 (1.24, 2.14)</td><td><0.001</td><td>1.64 (1.24, 2.15)</td><td><0.001</td></tr><tr><td>Pathological stage</td><td></td><td>0.720</td><td></td><td>0.158</td></tr><tr><td>IA</td><td>1</td><td></td><td>1</td><td></td></tr><tr><td>IB</td><td>0.87 (0.39, 1.90)</td><td></td><td>0.53 (0.22, 1.28)</td><td></td></tr><tr><td>Pleural invasion</td><td></td><td>0.056</td><td></td><td>0.057</td></tr><tr><td>PLX/PL0</td><td>1</td><td></td><td>1</td><td></td></tr><tr><td>PL1</td><td>1.94 (0.91, 4.12)</td><td></td><td>1.94 (0.91, 4.12)</td><td></td></tr><tr><td>PL2</td><td>3.39 (1.15, 8.79)</td><td></td><td>3.38 (1.15, 8.76)</td><td></td></tr><tr><td>Lymphatic invasion</td><td></td><td>0.020</td><td></td><td>0.019</td></tr><tr><td>Absent</td><td>1</td><td></td><td>1</td><td></td></tr><tr><td>Present</td><td>1.73 (1.09, 2.77)</td><td></td><td>1.74 (1.10, 2.78)</td><td></td></tr><tr><td>Vascular invasion</td><td></td><td>0.089</td><td></td><td>0.091</td></tr><tr><td>Absent</td><td>1</td><td></td><td>1</td><td></td></tr><tr><td>Present</td><td>1.52 (0.94, 2.44)</td><td></td><td>1.51 (0.94, 2.44)</td><td></td></tr><tr><td>Morphological grade</td><td></td><td>0.012</td><td></td><td>0.011</td></tr><tr><td>Low</td><td>1</td><td></td><td>1</td><td></td></tr><tr><td>Intermediate</td><td>3.08 (0.92, 19.13)</td><td></td><td>3.08 (0.92, 19.13)</td><td></td></tr><tr><td>High</td><td>5.09 (1.46, 32.18)</td><td></td><td>5.10 (1.46, 32.22)</td><td></td></tr></table>
95813bd7ed8769b0d9091de957b0b4ebe139a784b097f154823058aff67901d4.png
complex
<table><tr><td colspan="2">Variable</td><td>N&#176; total dogs</td><td>N&#176; positive<i>T. annae</i>dog (%)</td></tr><tr><td rowspan="3">Age (years)</td><td>&#8804;3</td><td>65</td><td>53 (81.54)**</td></tr><tr><td>&gt;3</td><td>47</td><td>22 (46.81)</td></tr><tr><td>unknown</td><td>8</td><td>0</td></tr><tr><td rowspan="3">Sex</td><td>Male</td><td>58</td><td>38 (65.5)</td></tr><tr><td>Female</td><td>55</td><td>37 (67.2)</td></tr><tr><td>unknown</td><td>7</td><td>0</td></tr><tr><td rowspan="3">Size (kg)</td><td>&#8804;22</td><td>77</td><td>59 (76.6)*</td></tr><tr><td>&gt;22</td><td>35</td><td>16 (45.71)</td></tr><tr><td>unknown</td><td>8</td><td>0</td></tr><tr><td rowspan="3">Breed</td><td>Pure breed</td><td>86</td><td>53 (61.6)</td></tr><tr><td>Crossbreed</td><td>33</td><td>22 (66.6)</td></tr><tr><td>unknown</td><td>1</td><td>0</td></tr><tr><td rowspan="4">Lifestyle</td><td>Hunting</td><td>75</td><td>56 (74.6)*</td></tr><tr><td>Companion</td><td>28</td><td>13 (46.4)</td></tr><tr><td>Guard</td><td>12</td><td>6 (50)</td></tr><tr><td>unknown</td><td>5</td><td>0</td></tr><tr><td rowspan="2">Habitat</td><td>Rural</td><td>96</td><td>64 (66.6)</td></tr><tr><td>Urban</td><td>24</td><td>11 (45.8)</td></tr><tr><td rowspan="3">Tick infestation</td><td>Yes</td><td>50</td><td>35 (70)</td></tr><tr><td>No</td><td>49</td><td>27 (55.1)</td></tr><tr><td>unknown</td><td>21</td><td>13 (10.8)</td></tr><tr><td rowspan="4">Seasonality</td><td>spring</td><td>20</td><td>14 (70)</td></tr><tr><td>summer</td><td>20</td><td>10 (50)</td></tr><tr><td>autumn</td><td>60</td><td>38 (63.3)</td></tr><tr><td>winter</td><td>20</td><td>13 (65)</td></tr></table>
<table><tr><td colspan="2">Variable</td><td>N° total dogs</td><td>N° positiveT. annaedog (%)</td></tr><tr><td rowspan="3">Age (years)</td><td>≤3</td><td>65</td><td>53 (81.54)**</td></tr><tr><td>>3</td><td>47</td><td>22 (46.81)</td></tr><tr><td>unknown</td><td>8</td><td>0</td></tr><tr><td rowspan="3">Sex</td><td>Male</td><td>58</td><td>38 (65.5)</td></tr><tr><td>Female</td><td>55</td><td>37 (67.2)</td></tr><tr><td>unknown</td><td>7</td><td>0</td></tr><tr><td rowspan="3">Size (kg)</td><td>≤22</td><td>77</td><td>59 (76.6)*</td></tr><tr><td>>22</td><td>35</td><td>16 (45.71)</td></tr><tr><td>unknown</td><td>8</td><td>0</td></tr><tr><td rowspan="3">Breed</td><td>Pure breed</td><td>86</td><td>53 (61.6)</td></tr><tr><td>Crossbreed</td><td>33</td><td>22 (66.6)</td></tr><tr><td>unknown</td><td>1</td><td>0</td></tr><tr><td rowspan="3">Lifestyle</td><td>Hunting</td><td>75</td><td>56 (74.6)*</td></tr><tr><td>Companion</td><td>28</td><td>13 (46.4)</td></tr><tr><td>Guard</td><td>12</td><td>6 (50)</td></tr></table>
<table><tr><td>Lifestyle</td><td>unknown</td><td>5</td><td>0</td></tr><tr><td rowspan="2">Habitat</td><td>Rural</td><td>96</td><td>64 (66.6)</td></tr><tr><td>Urban</td><td>24</td><td>11 (45.8)</td></tr><tr><td rowspan="3">Tick infestation</td><td>Yes</td><td>50</td><td>35 (70)</td></tr><tr><td>No</td><td>49</td><td>27 (55.1)</td></tr><tr><td>unknown</td><td>21</td><td>13 (10.8)</td></tr><tr><td rowspan="4">Seasonality</td><td>spring</td><td>20</td><td>14 (70)</td></tr><tr><td>summer</td><td>20</td><td>10 (50)</td></tr><tr><td>autumn</td><td>60</td><td>38 (63.3)</td></tr><tr><td>winter</td><td>20</td><td>13 (65)</td></tr></table>
53024b889399690f2c75e3e4f72a2422214711512498fd144db9c72b9d6d2c03.png
simple
<table><tr><td>Parameter</td><td>Correlation coefficient (<i>r</i>)</td><td><i>p</i> value</td></tr><tr><td>CD11a<i>vs.</i>sICAM-1</td><td>0.317</td><td>&gt;0.01</td></tr><tr><td>CD11a<i>vs.</i>sVCAM-1</td><td>0.366</td><td>&gt; 0.01</td></tr><tr><td>CD11b<i>vs.</i>sICAM-1</td><td>0.251</td><td>&gt; 0.05</td></tr><tr><td>CD11b<i>vs</i>. sVCAM-1</td><td>0.258</td><td>&gt; 0.05</td></tr><tr><td>CD49d<i>vs.</i>sICAM-1</td><td>0.315</td><td>&gt;0.01</td></tr><tr><td>CD49d<i>vs.</i>sVCAM-1</td><td>0.419</td><td>&gt; 0.01</td></tr><tr><td>sICAM-1<i>vs.</i>TNF-&#945;</td><td>0.355</td><td>&gt;0.01</td></tr><tr><td>sVCAM-1<i>vs.</i>TNF-&#945;</td><td>0.419</td><td>&gt; 0.01</td></tr></table>
<table><tr><td>Parameter</td><td>Correlation coefficient (r)</td><td>p value</td></tr><tr><td>CD11avs.sICAM-1</td><td>0.317</td><td>>0.01</td></tr><tr><td>CD11avs.sVCAM-1</td><td>0.366</td><td>> 0.01</td></tr><tr><td>CD11bvs.sICAM-1</td><td>0.251</td><td>> 0.05</td></tr><tr><td>CD11bvs. sVCAM-1</td><td>0.258</td><td>> 0.05</td></tr><tr><td>CD49dvs.s</td><td>0.31</td><td></td></tr></table>
<table><tr><td>ICAM-1</td><td>5</td><td>>0.01</td></tr><tr><td>CD49dvs.sVCAM-1</td><td>0.419</td><td>> 0.01</td></tr><tr><td>sICAM-1vs.TNF-α</td><td>0.355</td><td>>0.01</td></tr><tr><td>sVCAM-1vs.TNF-α</td><td>0.419</td><td>> 0.01</td></tr></table>
7a12717cb8e914bb1aff7e249d7ec262962423e79a0c5120c91ace0cb978b612.png
complex
<table><tr><td>Male</td><td>60 (67%)</td></tr><tr><td colspan="2">Age</td></tr><tr><td> 20&#8211;40 years of age</td><td>52 (58%)</td></tr><tr><td> 41&#8211;50 years of age</td><td>21 (23%)</td></tr><tr><td> &gt;50 years of age</td><td>17 (19%)</td></tr><tr><td colspan="2">Practitioner type</td></tr><tr><td> Attending physician</td><td>56 (62%)</td></tr><tr><td> Resident</td><td>13 (14%)</td></tr><tr><td> Extender</td><td>21 (23%)</td></tr><tr><td colspan="2">Experience</td></tr><tr><td> 1&#8211;5 years</td><td>38 (42%)</td></tr><tr><td> &gt;5&#8211;10 years</td><td>15 (17%)</td></tr><tr><td> &gt;10 years</td><td>37 (41%)</td></tr><tr><td colspan="2">Practice facility</td></tr><tr><td> Academic</td><td>54 (60%)</td></tr><tr><td> Private or community</td><td>32 (36%)</td></tr><tr><td> Urgent care</td><td>4 (4%)</td></tr><tr><td colspan="2">Average annual census</td></tr><tr><td> &lt;30 k</td><td>5 (6%)</td></tr><tr><td> 30&#8211;75 k</td><td>33 (37%)</td></tr><tr><td> &gt;75 k</td><td>52 (57%)</td></tr></table>
<table><tr><td>Male</td><td>60 (67%)</td></tr><tr><td colspan="2">Age</td></tr><tr><td>20–40 years of age</td><td>52 (58%)</td></tr><tr><td>41–50 years of age</td><td>21 (23%)</td></tr><tr><td>>50 years of age</td><td>17 (19%)</td></tr><tr><td colspan="2">Practitioner type</td></tr><tr><td>Attending physician</td><td>56 (62%)</td></tr></table>
<table><tr><td>Resident</td><td>13 (14%)</td></tr><tr><td>Extender</td><td>21 (23%)</td></tr><tr><td colspan="2">Experience</td></tr><tr><td>1–5 years</td><td>38 (42%)</td></tr><tr><td>>5–10 years</td><td>15 (17%)</td></tr><tr><td>>10 years</td><td>37 (41%)</td></tr><tr><td colspan="2">Practice facility</td></tr><tr><td>Academic</td><td>54 (60%)</td></tr><tr><td>Private or community</td><td>32 (36%)</td></tr><tr><td>Urgent care</td><td>4 (4%)</td></tr><tr><td colspan="2">Average annual census</td></tr><tr><td><30 k</td><td>5 (6%)</td></tr><tr><td>30–75 k</td><td>33 (37%)</td></tr><tr><td>>75 k</td><td>52 (57%)</td></tr></table>
8540d8024c206921be19b14137e08d9c442dcab253d563eb29bd24e31fa2ffcc.png
simple
<table><tr><td>Parameter</td><td>South Asian</td><td>Western European</td><td><i>p</i>-value</td></tr><tr><td>WB SAS</td><td>0.7 &#177; 0.8</td><td>1.8 &#177; 2.3</td><td>0.10</td></tr><tr><td>Head/neck SAS</td><td>0.5 &#177; 1.1</td><td>1.9 &#177; 4.0</td><td>0.21</td></tr><tr><td>Aorta SAS</td><td>0.9 &#177; 2.6</td><td>1.3 &#177; 3.1</td><td>0.59</td></tr><tr><td>Abdomen SAS</td><td>1.8 &#177; 3.8</td><td>3.2 &#177; 4.4</td><td>0.26</td></tr><tr><td>Iliofemoral SAS</td><td>0.0 &#177; 0.0</td><td>1.9 &#177; 6.9</td><td>0.048</td></tr><tr><td>Run-off SAS</td><td>0.7 &#177; 2.2</td><td>0.9 &#177; 2.9</td><td>0.77</td></tr><tr><td>Normal vessels</td><td>501 (97%)</td><td>1117 (95%)</td><td>0.2</td></tr><tr><td>Vessels with 1&#8211;50% stenosis</td><td>14 (3%)</td><td>46 (4%)</td><td>0.1</td></tr><tr><td>Vessels with 51&#8211;70% stenosis</td><td>1 (0.2%)</td><td>9 (0.8%)</td><td>0.08</td></tr><tr><td>Vessels with 71&#8211;99% stenosis</td><td>0</td><td>3 (0.2%)</td><td>0.3</td></tr><tr><td>Occluded vessels</td><td>0</td><td>1 (0.01%)</td><td>0.3</td></tr></table>
<table><tr><td>Parameter</td><td>South Asian</td></tr><tr><td>WB SAS</td><td>0.7 ± 0.8</td></tr><tr><td>Head/neck SAS</td><td>0.5 ± 1.1</td></tr><tr><td>Aorta SAS</td><td>0.9 ± 2.6</td></tr><tr><td>Abdomen SAS</td><td>1.8 ± 3.8</td></tr><tr><td>Iliofemoral SAS</td><td>0.0 ± 0.0</td></tr><tr><td>Run-off SAS</td><td>0.7 ± 2.2</td></tr><tr><td>Normal vessels</td><td>501 (97%)</td></tr><tr><td>Vessels with 1–50% stenosis</td><td>14 (3%)</td></tr><tr><td>Vessels with 51–70% stenosis</td><td>1 (0.2%)</td></tr><tr><td>Vessels with 71–99% stenosis</td><td>0</td></tr><tr><td>Occluded vessels</td><td>0</td></tr></table>
<table><tr><td>Western European</td><td>p-value</td></tr><tr><td>1.8 ± 2.3</td><td>0.10</td></tr><tr><td>1.9 ± 4.0</td><td>0.21</td></tr><tr><td>1.3 ± 3.1</td><td>0.59</td></tr><tr><td>3.2 ± 4.4</td><td>0.26</td></tr><tr><td>1.9 ± 6.9</td><td>0.048</td></tr><tr><td>0.9 ± 2.9</td><td>0.77</td></tr><tr><td>1117 (95%)</td><td>0.2</td></tr><tr><td>46 (4%)</td><td>0.1</td></tr><tr><td>9 (0.8%)</td><td>0.08</td></tr><tr><td>3 (0.2%)</td><td>0.3</td></tr><tr><td>1 (0.01%)</td><td>0.3</td></tr></table>
80ef5e308c1267fa5ad1a7186977032ba58dfae80090ee663433301f38f3ff68.png
complex
<table><tr><td rowspan="2">Occupational exposure</td><td colspan="2">Never smokers</td><td colspan="2">Former smokers</td><td colspan="2">Current smokers</td><td rowspan="2"><i>P</i> value<sup>b</sup></td></tr><tr><td>No.</td><td>%</td><td>No.</td><td>%</td><td>No.</td><td>%</td></tr><tr><td>Never exposed</td><td>52</td><td>70.3</td><td>38</td><td>48.7</td><td>32</td><td>69.6</td><td>Reference</td></tr><tr><td>Ever exposed (any agent)</td><td>22</td><td>29.7</td><td>40</td><td>51.3</td><td>14</td><td>30.4</td><td>0.01</td></tr><tr><td> Wood dust</td><td>12</td><td>16.2</td><td>21</td><td>26.9</td><td>10</td><td>21.7</td><td>0.10</td></tr><tr><td> Leather dust</td><td>10</td><td>13.5</td><td>17</td><td>21.8</td><td>2</td><td>4.3</td><td>0.01</td></tr><tr><td> Nickel compounds</td><td>0</td><td>0.0</td><td>2</td><td>2.6</td><td>2</td><td>4.3</td><td>0.23</td></tr><tr><td> Chromium compounds</td><td>1</td><td>1.4</td><td>3</td><td>3.8</td><td>0</td><td>0.0</td><td>0.16</td></tr><tr><td> PAH</td><td>0</td><td>0.0</td><td>1</td><td>1.3</td><td>1</td><td>2.2</td><td>0.47</td></tr><tr><td> Cork dust</td><td>1</td><td>1.4</td><td>0</td><td>0.0</td><td>0</td><td>0.0</td><td>0.51</td></tr></table>
<table><tr><td rowspan="2">Occupational exposure</td><td colspan="2">Never smokers</td><td>Former smokers</td></tr><tr><td>No.</td><td>%</td><td>No.</td></tr><tr><td>Never exposed</td><td>52</td><td>70.3</td><td>38</td></tr><tr><td>Ever exposed (any agent)</td><td>22</td><td>29.7</td><td>40</td></tr><tr><td>Wood dust</td><td>12</td><td>16.2</td><td>21</td></tr><tr><td>Leather dust</td><td>10</td><td>13.5</td><td>17</td></tr><tr><td>Nickel compounds</td><td>0</td><td>0.0</td><td>2</td></tr><tr><td>Chromium compounds</td><td>1</td><td>1.4</td><td>3</td></tr><tr><td>PAH</td><td>0</td><td>0.0</td><td>1</td></tr><tr><td>Cork dust</td><td>1</td><td>1.4</td><td>0</td></tr></table>
<table><tr><td>Former smokers</td><td colspan="2">Current smokers</td><td rowspan="2">P valueb</td></tr><tr><td>%</td><td>No.</td><td>%</td></tr><tr><td>48.7</td><td>32</td><td>69.6</td><td>Reference</td></tr><tr><td>51.3</td><td>14</td><td>30.4</td><td>0.01</td></tr><tr><td>26.9</td><td>10</td><td>21.7</td><td>0.10</td></tr><tr><td>21.8</td><td>2</td><td>4.3</td><td>0.01</td></tr><tr><td>2.6</td><td>2</td><td>4.3</td><td>0.23</td></tr><tr><td>3.8</td><td>0</td><td>0.0</td><td>0.16</td></tr><tr><td>1.3</td><td>1</td><td>2.2</td><td>0.47</td></tr><tr><td>0.0</td><td>0</td><td>0.0</td><td>0.51</td></tr></table>
75c73fd1c54ef007e92d97ac06a8f88014224584fc33dca89fd5a645322c1e68.png
complex
<table><tr><td>Product</td><td>Batch</td><td>Nonfucosylated (%)</td><td>Hybrid (%)</td><td>Sialylated (%)</td><td>Galactosylated (%)</td><td>High mannose (%)</td></tr><tr><td rowspan="3">MabThera</td><td>H0605</td><td>1.81 &#177; 0.04</td><td>5.00 &#177; 0.32</td><td>0.72 &#177; 0.08</td><td>43.34 &#177; 1.42</td><td>4.37 &#177; 0.42</td></tr><tr><td>N3518</td><td>1.69 &#177; 0.11</td><td>3.48 &#177; 0.24</td><td>0.98 &#177; 0.22</td><td>46.21 &#177; 1.54</td><td>3.19 &#177; 0.54</td></tr><tr><td>B62222</td><td>1.89 &#177; 0.11</td><td>2.91 &#177; 0.18</td><td>0.82 &#177; 0.12</td><td>45.58 &#177; 0.47</td><td>3.03 &#177; 0.17</td></tr><tr><td rowspan="3">Kikuzubam</td><td>5445130608</td><td>0.65 &#177; 0.21</td><td>2.72 &#177; 0.39</td><td>0.80 &#177; 0.21</td><td>57.08 &#177; 8.52</td><td>3.25 &#177; 0.43</td></tr><tr><td>5445131216</td><td>0.65 &#177; 0.21</td><td>2.80 &#177; 0.08</td><td>0.71 &#177; 0.13</td><td>56.35 &#177; 0.64</td><td>3.31 &#177; 0.16</td></tr><tr><td>5445131015</td><td>0.67 &#177; 0.05</td><td>3.19 &#177; 0.25</td><td>0.77 &#177; 0.13</td><td>54.26 &#177; 3.02</td><td>3.51 &#177; 0.23</td></tr></table>
<table><tr><td>Product</td><td>Batch</td><td>Nonfucosylated (%)</td><td>Hybrid (%)</td><td>Sialylated (%)</td><td>Galactosylated (%)</td><td>High mannose (%)</td></tr><tr><td rowspan="2">MabThera</td><td>H0605</td><td>1.81 ± 0.04</td><td>5.00 ± 0.32</td><td>0.72 ± 0.08</td><td>43.34 ± 1.42</td><td>4.37 ± 0.42</td></tr><tr><td>N3518</td><td>1.69 ± 0.11</td><td>3.48 ± 0.24</td><td>0.98 ± 0.22</td><td>46.21 ± 1.54</td><td>3.19 ± 0.54</td></tr></table>
<table><tr><td>Product</td><td>Batch</td><td>Nonfucosylated (%)</td><td>Hybrid (%)</td><td>Sialylated (%)</td><td>Galactosylated (%)</td><td>High mannose (%)</td></tr><tr><td>MabThera</td><td>B62222</td><td>1.89 ± 0.11</td><td>2.91 ± 0.18</td><td>0.82 ± 0.12</td><td>45.58 ± 0.47</td><td>3.03 ± 0.17</td></tr><tr><td rowspan="3">Kikuzubam</td><td>5445130608</td><td>0.65 ± 0.21</td><td>2.72 ± 0.39</td><td>0.80 ± 0.21</td><td>57.08 ± 8.52</td><td>3.25 ± 0.43</td></tr><tr><td>5445131216</td><td>0.65 ± 0.21</td><td>2.80 ± 0.08</td><td>0.71 ± 0.13</td><td>56.35 ± 0.64</td><td>3.31 ± 0.16</td></tr><tr><td>5445131015</td><td>0.67 ± 0.05</td><td>3.19 ± 0.25</td><td>0.77 ± 0.13</td><td>54.26 ± 3.02</td><td>3.51 ± 0.23</td></tr></table>
30ccba4cd7b20e4ced7a3bfe2cfbed28fb67694197e371cfdea0630a8d4d324a.png
complex
<table><tr><td>RIO&#8212;Psychosocial Measure</td><td colspan="2">Coefficient of Correlation</td></tr><tr><td>Temp. Fingers&#8212;Temp. Nose</td><td>0.450</td><td>**</td></tr><tr><td>&#8212;Interference General (BPI)</td><td>&#8722;0.390</td><td>*</td></tr><tr><td>&#8212;Interference Affective (BPI)</td><td>&#8722;0.517</td><td>*</td></tr><tr><td>&#8212;Interference Relationship (BPI)</td><td>&#8722;0.437</td><td>*</td></tr><tr><td>&#8212;Interference Sleep (BPI)</td><td>&#8722;0.600</td><td>***</td></tr><tr><td>&#8212;Interference Enjoy (BPI)</td><td>&#8722;0.665</td><td>***</td></tr><tr><td>&#8212;Pain (NAS of SF-MPQ)</td><td>&#8722;0.584</td><td>**</td></tr><tr><td>&#8212;Loneliness (L-UCLA)</td><td>&#8722;0.487</td><td>**</td></tr><tr><td>Temp. Chin&#8212;Temp. Maxillofacial</td><td>0.483</td><td>**</td></tr><tr><td>&#8212;Temp. Nose</td><td>0.459</td><td>**</td></tr><tr><td>&#8212;Internal Control of Anger (STAXI-2)</td><td>0.383</td><td>*</td></tr><tr><td>&#8212;Alexithymia (TAS)</td><td>&#8722;0.446</td><td>*</td></tr><tr><td>&#8212;Supression (EQR)</td><td>&#8722;0.481</td><td>*</td></tr><tr><td>Temp. Maxillary&#8212;Temp. Nose </td><td>0.821</td><td>***</td></tr><tr><td>&#8212;Interference Sleep (BPI)</td><td>&#8722;0.520</td><td>**</td></tr><tr><td>&#8212;Interference Enjoy (BPI)</td><td>&#8722;0.461</td><td>**</td></tr><tr><td>&#8212;Pain (NAS of SF-MPQ)</td><td>&#8722;0.504</td><td>**</td></tr><tr><td>Temp. Nose&#8212;Interference Sleep (BPI)</td><td>&#8722;0.443</td><td>*</td></tr><tr><td>&#8212;Pain (NAS of SF-MPQ)</td><td>&#8722;0.413</td><td>*</td></tr><tr><td>Temp. Periorbital&#8212;Temp. Forehead</td><td>0.469</td><td>**</td></tr><tr><td>&#8212;Reappraisal (EQR)</td><td>&#8722;0.485</td><td>*</td></tr></table>
<table><tr><td>RIO—Psychosocial Measure</td><td colspan="2">Coefficient of Correlation</td></tr><tr><td>Temp. Fingers—Temp. Nose</td><td>0.450</td><td>**</td></tr><tr><td>—Interference General (BPI)</td><td>−0.390</td><td>*</td></tr><tr><td>—Interference Affective (BPI)</td><td>−0.517</td><td>*</td></tr><tr><td>—Interference Relationship (BPI)</td><td>−0.437</td><td>*</td></tr><tr><td>—Interference Sleep (BPI)</td><td>−0.600</td><td>***</td></tr><tr><td>—Interference Enjoy (BPI)</td><td>−0.665</td><td>***</td></tr><tr><td>—Pain (NAS of SF-MPQ)</td><td>−0.584</td><td>**</td></tr><tr><td>—Loneliness (L-UCLA)</td><td>−0.487</td><td>**</td></tr><tr><td>Temp. Chin—Temp. Maxillofacial</td><td>0.483</td><td>**</td></tr><tr><td>—Temp. Nose</td><td>0.459</td><td>**</td></tr><tr><td>—Internal Control of Anger (STAXI-2)</td><td>0.383</td><td>*</td></tr><tr><td>—Alexithymia (TAS)</td><td>−0.446</td><td>*</td></tr><tr><td>—Supression (EQR)</td><td>−0.481</td><td>*</td></tr><tr><td>Temp. Maxillary—Temp. Nose</td><td>0.821</td><td>***</td></tr><tr><td>—Interference Sleep (BPI)</td><td>−0.520</td><td>**</td></tr><tr><td>—Interference Enjoy (BPI)</td><td>−0.461</td><td>**</td></tr><tr><td>—Pain (NAS of SF-MPQ)</td><td>−0.504</td><td>**</td></tr><tr><td>Temp. Nose—Interference Sleep (BPI)</td><td>−0.443</td><td>*</td></tr><tr><td>—Pain (NAS of SF-MPQ)</td><td>−0.413</td><td>*</td></tr></table>
<table><tr><td>Temp. Periorbital—Temp. Forehead</td><td>0.469</td><td>**</td></tr><tr><td>—Reappraisal (EQR)</td><td>−0.485</td><td>*</td></tr></table>
27caa1b569164e8f6b8bedaf17abdecb0c4aba16c47899e7185a9ef4d034696a.png
simple
<table><tr><td>Experiment</td><td>Total reads</td><td>Aligned reads</td><td>Mean PCR duplicates (%)</td><td>Aligned reads on target</td><td>On-target rate (%)</td><td>Uniquely aligned reads<sup>a</sup></td><td>Uniquely aligned reads on target<sup>a</sup></td><td>On-target rate (%)<sup>a</sup></td><td>Mean coverage on target</td></tr><tr><td>dCATCH-SeqCATCH-Seq</td><td>853,358841,154</td><td>414,965802,931</td><td>47.42.8</td><td>382,625291,808</td><td>92.2136.34</td><td>406,331762,445</td><td>379,084289,558</td><td>93.2937.98</td><td>145.98110.18</td></tr></table>
<table><tr><td>E</td><td>Total rea</td><td>Align</td><td>Mean PCR d</td><td>Aligned re</td><td>On-target r</td><td>Uniquel</td><td>Uniquely aligned reads</td><td>On-tar</td><td>Mean coverag</td></tr></table>
<table><tr><td>xperiment</td><td>ds</td><td>ed reads</td><td>uplicates (%)</td><td>ads on target</td><td>ate (%)</td><td>y aligned readsa</td><td> on targeta</td><td>get rate (%)a</td><td>e on target</td></tr><tr><td>dCATCH-SeqCATCH-Seq</td><td>853,358841,154</td><td>414,965802,931</td><td>47.42.8</td><td>382,625291,808</td><td>92.2136.34</td><td>406,331762,445</td><td>379,084289,558</td><td>93.2937.98</td><td>145.98110.18</td></tr></table>
040d9be7f18437d3b1e9baeb56b6af288ece7e262d308b52da266c9fd725d777.png
complex
<table><tr><td rowspan="2">Treatment</td><td rowspan="2">Dose (<i>&#956;</i>g/plate)</td><td colspan="4">Number of His<sup>+</sup> revertants colonies/plate</td></tr><tr><td>TA97a</td><td>TA98</td><td>TA100</td><td>TA102</td></tr><tr><td>Spontaneous</td><td> </td><td>140.0 &#177; 4.0</td><td>31.0 &#177; 3.6</td><td>128.7 &#177; 9.8</td><td>245.7 &#177; 23.3</td></tr><tr><td>Positive control (NaN<sub>3</sub>)</td><td>1.5</td><td>246.3 &#177; 16.0</td><td>52.7 &#177; 2.1</td><td>352.0 &#177; 33.0</td><td>343.3 &#177; 33.3</td></tr><tr><td rowspan="4"><sup>a</sup><i>Murraya koenigii </i></td><td>12.5</td><td>164.3 &#177; 12.3</td><td>46.0 &#177; 4.0</td><td>191.7 &#177; 13.3</td><td>286.7 &#177; 26.3</td></tr><tr><td>25</td><td>145.0 &#177; 15.5</td><td>37.3 &#177; 7.0</td><td>172.3 &#177; 18.9</td><td>260.0 &#177; 24.1</td></tr><tr><td>50</td><td>124.7 &#177; 9.1</td><td>30.7 &#177; 8.5</td><td>153.0 &#177; 19.7</td><td>245.3 &#177; 24.4</td></tr><tr><td>100</td><td>118.0 &#177; 10.5</td><td>24.0 &#177; 4.6</td><td>127.0 &#177; 15.5</td><td>228.3 &#177; 19.6</td></tr><tr><td rowspan="4"><sup>b</sup><i>Murraya koenigii +</i> NaN<sub>3</sub></td><td>12.5</td><td>225.3 &#177; 33.6 (25.6)</td><td>51.3 &#177; 6.0 (20.0)</td><td>316.3 &#177; 32.0 (22.3)</td><td>332.3 &#177; 34.9 (19.4)</td></tr><tr><td>25</td><td>200.7 &#177; 22.7* (45.1)</td><td>45.3 &#177; 4.2 (47.8)</td><td>258.0 &#177; 29.6* (52.3)</td><td>313.0 &#177; 32.1 (36.4)</td></tr><tr><td>50</td><td>168.0 &#177; 22.3** (64.4)</td><td>39.0 &#177; 8.2* (62.1)</td><td>212.7 &#177; 26.6** (70.0)</td><td>292.7 &#177; 18.6 (51.7)</td></tr><tr><td>100</td><td>137.3 &#177; 12.7*** (84.9)</td><td>31.7 &#177; 6.5** (73.2)</td><td>162.0 &#177; 21.0** (84.4)</td><td>260.3 &#177; 14.0* (72.2)</td></tr><tr><td><i>F</i>value </td><td> </td><td>18.069</td><td>8.288</td><td>33.690</td><td>6.917</td></tr><tr><td><i>R</i><sup>2</sup>value</td><td> </td><td>0.999</td><td>0.953</td><td>0.969</td><td>0.996</td></tr></table>
<table><tr><td rowspan="2">Treatment</td><td rowspan="2">Dose (μg/plate)</td><td colspan="2">Number of His+ revertants colonies/plate</td></tr><tr><td>TA97a</td><td>TA98</td></tr><tr><td>Spontaneous</td><td></td><td>140.0 ± 4.0</td><td>31.0 ± 3.6</td></tr><tr><td>Positive control (NaN3)</td><td>1.5</td><td>246.3 ± 16.0</td><td>52.7 ± 2.1</td></tr><tr><td rowspan="4">aMurraya koenigii</td><td>12.5</td><td>164.3 ± 12.3</td><td>46.0 ± 4.0</td></tr><tr><td>25</td><td>145.0 ± 15.5</td><td>37.3 ± 7.0</td></tr><tr><td>50</td><td>124.7 ± 9.1</td><td>30.7 ± 8.5</td></tr><tr><td>100</td><td>118.0 ± 10.5</td><td>24.0 ± 4.6</td></tr><tr><td rowspan="4">bMurraya koenigii + NaN3</td><td>12.5</td><td>225.3 ± 33.6 (25.6)</td><td>51.3 ± 6.0 (20.0)</td></tr><tr><td>25</td><td>200.7 ± 22.7* (45.1)</td><td>45.3 ± 4.2 (47.8)</td></tr><tr><td>50</td><td>168.0 ± 22.3** (64.4)</td><td>39.0 ± 8.2* (62.1)</td></tr><tr><td>100</td><td>137.3 ± 12.7*** (84.9)</td><td>31.7 ± 6.5** (73.2)</td></tr><tr><td>Fvalue</td><td></td><td>18.069</td><td>8.288</td></tr><tr><td>R2value</td><td></td><td>0.999</td><td>0.953</td></tr></table>
<table><tr><td colspan="2">Number of His+ revertants colonies/plate</td></tr><tr><td>TA100</td><td>TA102</td></tr><tr><td>128.7 ± 9.8</td><td>245.7 ± 23.3</td></tr><tr><td>352.0 ± 33.0</td><td>343.3 ± 33.3</td></tr><tr><td>191.7 ± 13.3</td><td>286.7 ± 26.3</td></tr><tr><td>172.3 ± 18.9</td><td>260.0 ± 24.1</td></tr><tr><td>153.0 ± 19.7</td><td>245.3 ± 24.4</td></tr><tr><td>127.0 ± 15.5</td><td>228.3 ± 19.6</td></tr><tr><td>316.3 ± 32.0 (22.3)</td><td>332.3 ± 34.9 (19.4)</td></tr><tr><td>258.0 ± 29.6* (52.3)</td><td>313.0 ± 32.1 (36.4)</td></tr><tr><td>212.7 ± 26.6** (70.0)</td><td>292.7 ± 18.6 (51.7)</td></tr><tr><td>162.0 ± 21.0** (84.4)</td><td>260.3 ± 14.0* (72.2)</td></tr><tr><td>33.690</td><td>6.917</td></tr><tr><td>0.969</td><td>0.996</td></tr></table>
74d4a05312fa850e84283a72ec46c51633cbabee7f8342fe6ebbd5b6754b8320.png
complex
<table><tr><td rowspan="2">Regression indices and explanatory variable</td><td>Dependent variable<sup>&#8225;</sup></td></tr><tr><td>Eggs</td><td>Excreta</td></tr><tr><td>Intercept</td><td>-1.33<sup>**</sup> (0.45)</td><td>2.97<sup>**</sup> (0.23)</td></tr><tr><td>Regression coefficients</td><td></td><td></td></tr><tr><td>Area (Reference: Faridpur)</td><td></td><td></td></tr><tr><td>Madaripur</td><td>0.46<sup>**</sup> (0.15)</td><td>0.09 (0.08)</td></tr><tr><td>Chandpur</td><td>-0.29<sup>*</sup> (0.15)</td><td>0.01 (0.08)</td></tr><tr><td>Satkhira</td><td>-0.28 (0.15)</td><td>0.02 (0.08)</td></tr><tr><td>Jessore</td><td>-0.22 (0.15)</td><td>0.03 (0.08)</td></tr><tr><td>Age (weeks)</td><td>0.01<sup>**</sup> (0.00)</td><td>-0.00 (0.00)</td></tr><tr><td>Feed type (Reference: Commercial feed)</td><td>0.00 (0.13)</td><td>0.06 (0.07)</td></tr><tr><td>Arsenic in drinking-water (ppb)</td><td>0.41<sup>**</sup> (0.03)</td><td>0.44<sup>**</sup> (0.02)</td></tr><tr><td>Arsenic in feed (ppb)</td><td>0.40<sup>**</sup> (0.09)</td><td>0.52<sup>**</sup> (0.04)</td></tr><tr><td>R<sup>2</sup></td><td>0.55</td><td>0.82</td></tr><tr><td>F value</td><td>36.83<sup>**</sup></td><td>133.42<sup>**</sup></td></tr></table>
<table><tr><td rowspan="2">Regression indices and explanatory variable</td><td>Dependent variable‡</td><td></td></tr><tr><td>Eggs</td><td>Excreta</td></tr><tr><td>Intercept</td><td>-1.33** (0.45)</td><td>2.97** (0.23)</td></tr><tr><td>Regression coefficients</td><td></td><td></td></tr><tr><td>Area (Reference: Faridpur)</td><td></td><td></td></tr><tr><td>Madaripur</td><td>0.46** (0.15)</td><td>0.09 (0.08)</td></tr></table>
<table><tr><td rowspan="2">Regression indices and explanatory variable</td><td>Dependent variable‡</td><td></td></tr><tr><td>Eggs</td><td>Excreta</td></tr><tr><td>Chandpur</td><td>-0.29* (0.15)</td><td>0.01 (0.08)</td></tr><tr><td>Satkhira</td><td>-0.28 (0.15)</td><td>0.02 (0.08)</td></tr><tr><td>Jessore</td><td>-0.22 (0.15)</td><td>0.03 (0.08)</td></tr><tr><td>Age (weeks)</td><td>0.01** (0.00)</td><td>-0.00 (0.00)</td></tr><tr><td>Feed type (Reference: Commercial feed)</td><td>0.00 (0.13)</td><td>0.06 (0.07)</td></tr><tr><td>Arsenic in drinking-water (ppb)</td><td>0.41** (0.03)</td><td>0.44** (0.02)</td></tr><tr><td>Arsenic in feed (ppb)</td><td>0.40** (0.09)</td><td>0.52** (0.04)</td></tr><tr><td>R2</td><td>0.55</td><td>0.82</td></tr><tr><td>F value</td><td>36.83**</td><td>133.42**</td></tr></table>
8cf555500eb20f260f15e33d00350fc76b914c05c41e5932314ae15933bb22f7.png
simple
<table><tr><td>Species</td><td>Accession used for sequencing</td><td>Raw paired-end reads (DNA-, RNA-seq) (M)</td><td>Trimmed paired-end reads (DNA-, RNA-seq) (M)</td><td>Repetitive fraction (%) (SE)</td></tr><tr><td><i>H. agrestis</i></td><td>673199</td><td>38.3&#8211;40.4,40.0&#8211;44.0</td><td>28.6&#8211;29.5,36.3&#8211;39.9</td><td>83.33 (0.02)</td></tr><tr><td><i>H. carnosus</i></td><td>649956</td><td>34.0&#8211;38.6,48.5&#8211;56.9</td><td>24.6&#8211;28.3,44.0&#8211;51.7</td><td>74.48 (0.04)</td></tr><tr><td><i>H. porteri</i></td><td>649918</td><td>42.4&#8211;63.5,35.8&#8211;49.7</td><td>31.1&#8211;48.0,32.6&#8211;45.2</td><td>74.78 (0.20)</td></tr></table>
<table><tr><td>Species</td><td>Accession used for sequencing</td><td>Raw paired-end reads (DNA-, RNA-seq) (M)</td><td>Trimmed paired-end reads (DNA-, RNA-seq) (M)</td><td>Repetitive fraction (%) (SE)</td></tr></table>
<table><tr><td>H. agrestis</td><td>673199</td><td>38.3–40.4,40.0–44.0</td><td>28.6–29.5,36.3–39.9</td><td>83.33 (0.02)</td></tr><tr><td>H. carnosus</td><td>649956</td><td>34.0–38.6,48.5–56.9</td><td>24.6–28.3,44.0–51.7</td><td>74.48 (0.04)</td></tr><tr><td>H. porteri</td><td>649918</td><td>42.4–63.5,35.8–49.7</td><td>31.1–48.0,32.6–45.2</td><td>74.78 (0.20)</td></tr></table>
e66ba8880463dd9006f424eab31ede3150fb45d8c451c9244c952257b8b54077.png
simple
<table><tr><td>Predictor</td><td>&#946; coefficient</td><td>95% CI</td><td>Unadjusted <i>p</i> value<sup>a</sup></td></tr><tr><td>Age</td><td>0.08</td><td>0.02&#8211;0.15</td><td>0.009</td></tr><tr><td>Female</td><td>&#8722;0.22</td><td>&#8722;1.17 to 0.74</td><td>0.655</td></tr><tr><td>Marital status</td><td>0.02</td><td>&#8722;0.34 to 0.38</td><td>0.920</td></tr><tr><td>Burn</td><td>1.17</td><td>0.27&#8211;2.07</td><td>0.012</td></tr><tr><td>Total body surface area %</td><td>&#8722;0.01</td><td>&#8722;0.04 to 0.02</td><td>0.577</td></tr><tr><td>Graft</td><td>&#8722;1.67</td><td>&#8722;2.84 to &#8722;0.49</td><td>0.006</td></tr><tr><td>BDI</td><td>0.09</td><td>0.06&#8211;0.13</td><td>&lt;0.001</td></tr><tr><td>IES-R</td><td>0.04</td><td>0.02&#8211;0.05</td><td>&lt;0.001</td></tr><tr><td>Pre-morbid employment</td><td>0.54</td><td>&#8722;0.16 to 1.24</td><td>0.131</td></tr><tr><td>Return to same employment</td><td>2.08</td><td>1.06&#8211;3.10</td><td>&lt;0.001</td></tr><tr><td>Time off from work</td><td>0.51</td><td>0.20&#8211;0.82</td><td>0.001</td></tr></table>
<table><tr><td>Predictor</td><td>β coefficient</td><td>95% CI</td><td>Unadjusted p valuea</td></tr><tr><td>Age</td><td>0.08</td><td>0.02–0.15</td><td>0.009</td></tr><tr><td>Female</td><td>−0.22</td><td>−1.17 to 0.74</td><td>0.655</td></tr><tr><td>Marital status</td><td>0.02</td><td>−0.34 to 0.38</td><td>0.920</td></tr><tr><td>Burn</td><td>1.17</td><td>0.27–2.07</td><td>0.012</td></tr><tr><td>Total body surface area %</td><td>−0.01</td><td>−0.04 to 0.02</td><td>0.577</td></tr><tr><td>Graft</td><td>−1.67</td><td>−2.84 to −0.49</td><td>0.006</td></tr><tr><td>BDI</td><td>0.09</td><td>0.06–0.13</td><td><0.001</td></tr><tr><td>IES-R</td><td>0.04</td><td>0.02–0.05</td><td><0.001</td></tr></table>
<table><tr><td>Predictor</td><td>β coefficient</td><td>95% CI</td><td>Unadjusted p valuea</td></tr><tr><td>Pre-morbid employment</td><td>0.54</td><td>−0.16 to 1.24</td><td>0.131</td></tr><tr><td>Return to same employment</td><td>2.08</td><td>1.06–3.10</td><td><0.001</td></tr><tr><td>Time off from work</td><td>0.51</td><td>0.20–0.82</td><td>0.001</td></tr></table>
84d417166909c96e33d16709eee8c679dd5ddeceb0ad9e652d3eec119df9cb14.png
complex
<table><tr><td colspan="2"> </td><td colspan="4">Women who selected specified method</td><td> </td><td colspan="4">Women who did not select specified method</td></tr><tr><td>Perception statement</td><td>Method</td><td>Strongly agree/agree n (%)</td><td>Strongly disagree/disagree n (%)</td><td>No opinion/do not know n (%)</td><td>Missing (n)</td><td>Method (%)</td><td>Strongly agree/agree (%)</td><td>Strongly disagree/disagree (%)</td><td>No opinion/do not know (%)</td><td>Missing (n)</td></tr><tr><td rowspan="3">Prevents pregnancy effectively</td><td>Pill</td><td>8969 (95.7)</td><td>92 (1.0)</td><td>309 (3.3)</td><td>74</td><td>Pill</td><td>8263 (90.2)</td><td>222 (2.4)</td><td>680 (7.4)</td><td>178</td></tr><tr><td>Patch</td><td>1284 (84.7)</td><td>11 (0.7)</td><td>221(14.6)</td><td>33</td><td>Patch</td><td>10525(63.6)</td><td>469 (2.8)</td><td>5546(33.5)</td><td>698</td></tr><tr><td>Ring</td><td>4837 (89.1)</td><td>13 (0.2)</td><td>580 (10.7)</td><td>110</td><td>Ring</td><td>8348 (66.2)</td><td>270 (2.1)</td><td>3986(31.6)</td><td>643</td></tr><tr><td rowspan="3">Many side effects</td><td>Pill</td><td>2351 (25.2)</td><td>3941 (42.3)</td><td>3029 (32.5)</td><td>123</td><td>Pill</td><td>4258 (46.5)</td><td>2344 (25.6)</td><td>2564 (28.0)</td><td>177</td></tr><tr><td>Patch</td><td>151 (10.1)</td><td>649 (43.4)</td><td>696 (46.5)</td><td>53</td><td>Patch</td><td>2429 (14.7)</td><td>3435 (20.9)</td><td>10610 (64.4)</td><td>764</td></tr><tr><td>Ring</td><td>361 (6.7)</td><td>2861 (52.9)</td><td>2182 (40.4)</td><td>136</td><td>Ring</td><td>1335 (10.6)</td><td>3200 (25.5)</td><td>8038 (63.9)</td><td>674</td></tr><tr><td rowspan="3">Can be dangerous for your health</td><td>Pill</td><td>1704 (18.3)</td><td>4528 (48.7)</td><td>3073 (33.0)</td><td>139</td><td>Pill</td><td>3000 (32.8)</td><td>3092 (33.8)</td><td>3045 (33.3)</td><td>206</td></tr><tr><td>Patch</td><td>119 (7.9)</td><td>804 (53.7)</td><td>574 (38.3)</td><td>52</td><td>Patch</td><td>1575 (9.6)</td><td>6082 (37.0)</td><td>8760 (53.4)</td><td>821</td></tr><tr><td>Ring</td><td>339 (6.3)</td><td>3276 (60.7)</td><td>1785 (33.1)</td><td>140</td><td>Ring</td><td>956 (7.6)</td><td>4824 (38.4)</td><td>6774 (54.0)</td><td>693</td></tr><tr><td rowspan="3">Easy to use</td><td>Pill</td><td>8627 (92.5)</td><td>214 (2.3)</td><td>489 (5.2)</td><td>114</td><td>Pill</td><td>6293 (69.2)</td><td>1473 (16.2)</td><td>1334 (14.7)</td><td>243</td></tr><tr><td>Patch</td><td>1318 (87.7)</td><td>34 (2.3)</td><td>151 (10.1)</td><td>46</td><td>Patch</td><td>9248 (56.4)</td><td>1779 (10.8)</td><td>5382 (32.8)</td><td>829</td></tr><tr><td>Ring</td><td>4188 (77.5)</td><td>149 (2.8)</td><td>1067 (19.7)</td><td>136</td><td>Ring</td><td>4257 (33.9)</td><td>2568 (20.5)</td><td>5716 (45.6)</td><td>706</td></tr><tr><td rowspan="3">Easy to forget</td><td>Pill</td><td>4894 (52.7)</td><td>2457 (26.5)</td><td>1931 (20.8)</td><td>162</td><td>Pill</td><td>7140 (78.3)</td><td>983 (10.8)</td><td>998 (10.9)</td><td>222</td></tr><tr><td>Patch</td><td>229 (15.3)</td><td>860 (57.6)</td><td>405 (27.1)</td><td>55</td><td>Patch</td><td>4716 (28.7)</td><td>4635 (28.2)</td><td>7073 (43.1)</td><td>814</td></tr><tr><td>Ring</td><td>713 (13.3)</td><td>3179 (59.2)</td><td>1475 (27.5)</td><td>173</td><td>Ring</td><td>2532 (20.2)</td><td>4072 (32.6)</td><td>5902 (47.2)</td><td>741</td></tr><tr><td rowspan="3">Regular menstrual bleeding</td><td>Pill</td><td>8274 (88.8)</td><td>221 (2.4)</td><td>825 (8.9)</td><td>124</td><td>Pill</td><td>7571 (82.9)</td><td>405 (4.4)</td><td>1155 (12.7)</td><td>212</td></tr><tr><td>Patch</td><td>1063 (70.7)</td><td>31 (2.1)</td><td>410 (27.3)</td><td>45</td><td>Patch</td><td>8177 (49.9)</td><td>431 (2.6)</td><td>7789 (47.5)</td><td>841</td></tr><tr><td>Ring</td><td>4064 (75.5)</td><td>86 (1.6)</td><td>1233 (22.9)</td><td>157</td><td>Ring</td><td>6003 (47.9)</td><td>346 (2.8)</td><td>6180 (49.3)</td><td>718</td></tr><tr><td rowspan="3">Protects against cancer</td><td>Pill</td><td>2686 (28.9)</td><td>1542 (16.6)</td><td>5076 (54.6)</td><td>140</td><td>Pill</td><td>2687 (29.5)</td><td>1495 (16.4)</td><td>4941 (54.2)</td><td>220</td></tr><tr><td>Patch</td><td>358 (23.9)</td><td>204 (13.6)</td><td>938 (62.5)</td><td>49</td><td>Patch</td><td>2735 (16.7)</td><td>2458 (15.0)</td><td>11231 (68.4)</td><td>814</td></tr><tr><td>Ring</td><td>1457 (27.0)</td><td>645 (11.9)</td><td>3299 (61.1)</td><td>139</td><td>Ring</td><td>1920 (15.3)</td><td>1896 (15.1)</td><td>8725 (69.6)</td><td>706</td></tr><tr><td>Many women use it</td><td>Pill</td><td>8361 (89.3)</td><td>82 (0.9)</td><td>920 (9.8)</td><td>81</td><td>Pill</td><td>7455 (81.3)</td><td>256 (2.8)</td><td>1454 (15.8)</td><td>178</td></tr><tr><td> </td><td>Patch</td><td>413 (27.4)</td><td>185 (12.3)</td><td>910 (60.3)</td><td>41</td><td>Patch</td><td>1744 (10.6)</td><td>4154 (25.2)</td><td>10584 (64.2)</td><td>756</td></tr><tr><td> </td><td>Ring</td><td>1316 (24.4)</td><td>706 (13.1)</td><td>3379 (62.6)</td><td>139</td><td>Ring</td><td>1310 (10.4)</td><td>2756 (21.9)</td><td>8514 (67.7)</td><td>667</td></tr></table>
<table><tr><td colspan="2"></td><td colspan="4">Women who selected specified method</td><td></td><td colspan="4">Women who did not select specified method</td></tr><tr><td>Perception statement</td><td>Method</td><td>Strongly agree/agree n (%)</td><td>Strongly disagree/disagree n (%)</td><td>No opinion/do not know n (%)</td><td>Missing (n)</td><td>Method (%)</td><td>Strongly agree/agree (%)</td><td>Strongly disagree/disagree (%)</td><td>No opinion/do not know (%)</td><td>Missing (n)</td></tr><tr><td rowspan="3">Prevents pregnancy effectively</td><td>Pill</td><td>8969 (95.7)</td><td>92 (1.0)</td><td>309 (3.3)</td><td>74</td><td>Pill</td><td>8263 (90.2)</td><td>222 (2.4)</td><td>680 (7.4)</td><td>178</td></tr><tr><td>Patch</td><td>1284 (84.7)</td><td>11 (0.7)</td><td>221(14.6)</td><td>33</td><td>Patch</td><td>10525(63.6)</td><td>469 (2.8)</td><td>5546(33.5)</td><td>698</td></tr><tr><td>Ring</td><td>4837 (89.1)</td><td>13 (0.2)</td><td>580 (10.7)</td><td>110</td><td>Ring</td><td>8348 (66.2)</td><td>270 (2.1)</td><td>3986(31.6)</td><td>643</td></tr><tr><td rowspan="3">Many side effects</td><td>Pill</td><td>2351 (25.2)</td><td>3941 (42.3)</td><td>3029 (32.5)</td><td>123</td><td>Pill</td><td>4258 (46.5)</td><td>2344 (25.6)</td><td>2564 (28.0)</td><td>177</td></tr><tr><td>Patch</td><td>151 (10.1)</td><td>649 (43.4)</td><td>696 (46.5)</td><td>53</td><td>Patch</td><td>2429 (14.7)</td><td>3435 (20.9)</td><td>10610 (64.4)</td><td>764</td></tr><tr><td>Ring</td><td>361 (6.7)</td><td>2861 (52.9)</td><td>2182 (40.4)</td><td>136</td><td>Ring</td><td>1335 (10.6)</td><td>3200 (25.5)</td><td>8038 (63.9)</td><td>674</td></tr><tr><td rowspan="3">Can be dangerous for your health</td><td>Pill</td><td>1704 (18.3)</td><td>4528 (48.7)</td><td>3073 (33.0)</td><td>139</td><td>Pill</td><td>3000 (32.8)</td><td>3092 (33.8)</td><td>3045 (33.3)</td><td>206</td></tr><tr><td>Patch</td><td>119 (7.9)</td><td>804 (53.7)</td><td>574 (38.3)</td><td>52</td><td>Patch</td><td>1575 (9.6)</td><td>6082 (37.0)</td><td>8760 (53.4)</td><td>821</td></tr><tr><td>Ring</td><td>339 (6.3)</td><td>3276 (60.7)</td><td>1785 (33.1)</td><td>140</td><td>Ring</td><td>956 (7.6)</td><td>4824 (38.4)</td><td>6774 (54.0)</td><td>693</td></tr><tr><td rowspan="3">Easy to use</td><td>Pill</td><td>8627 (92.5)</td><td>214 (2.3)</td><td>489 (5.2)</td><td>114</td><td>Pill</td><td>6293 (69.2)</td><td>1473 (16.2)</td><td>1334 (14.7)</td><td>243</td></tr><tr><td>Patch</td><td>1318 (87.7)</td><td>34 (2.3)</td><td>151 (10.1)</td><td>46</td><td>Patch</td><td>9248 (56.4)</td><td>1779 (10.8)</td><td>5382 (32.8)</td><td>829</td></tr><tr><td>Ring</td><td>4188 (77.5)</td><td>149 (2.8)</td><td>1067 (19.7)</td><td>136</td><td>Ring</td><td>4257 (33.9)</td><td>2568 (20.5)</td><td>5716 (45.6)</td><td>706</td></tr><tr><td rowspan="3">Easy to forget</td><td>Pill</td><td>4894 (52.7)</td><td>2457 (26.5)</td><td>1931 (20.8)</td><td>162</td><td>Pill</td><td>7140 (78.3)</td><td>983 (10.8)</td><td>998 (10.9)</td><td>222</td></tr><tr><td>Patch</td><td>229 (15.3)</td><td>860 (57.6)</td><td>405 (27.1)</td><td>55</td><td>Patch</td><td>4716 (28.7)</td><td>4635 (28.2)</td><td>7073 (43.1)</td><td>814</td></tr><tr><td>Ring</td><td>713 (13.3)</td><td>3179 (59.2)</td><td>1475 (27.5)</td><td>173</td><td>Ring</td><td>2532 (20.2)</td><td>4072 (32.6)</td><td>5902 (47.2)</td><td>741</td></tr><tr><td rowspan="2">Regular menstrual bleeding</td><td>Pill</td><td>8274 (88.8)</td><td>221 (2.4)</td><td>825 (8.9)</td><td>124</td><td>Pill</td><td>7571 (82.9)</td><td>405 (4.4)</td><td>1155 (12.7)</td><td>212</td></tr><tr><td>Patch</td><td>1063 (70.7)</td><td>31 (2.1)</td><td>410 (27.3)</td><td>45</td><td>Patch</td><td>8177 (49.9)</td><td>431 (2.6)</td><td>7789 (47.5)</td><td>841</td></tr></table>
<table><tr><td>Regular menstrual bleeding</td><td>Ring</td><td>4064 (75.5)</td><td>86 (1.6)</td><td>1233 (22.9)</td><td>157</td><td>Ring</td><td>6003 (47.9)</td><td>346 (2.8)</td><td>6180 (49.3)</td><td>718</td></tr><tr><td rowspan="3">Protects against cancer</td><td>Pill</td><td>2686 (28.9)</td><td>1542 (16.6)</td><td>5076 (54.6)</td><td>140</td><td>Pill</td><td>2687 (29.5)</td><td>1495 (16.4)</td><td>4941 (54.2)</td><td>220</td></tr><tr><td>Patch</td><td>358 (23.9)</td><td>204 (13.6)</td><td>938 (62.5)</td><td>49</td><td>Patch</td><td>2735 (16.7)</td><td>2458 (15.0)</td><td>11231 (68.4)</td><td>814</td></tr><tr><td>Ring</td><td>1457 (27.0)</td><td>645 (11.9)</td><td>3299 (61.1)</td><td>139</td><td>Ring</td><td>1920 (15.3)</td><td>1896 (15.1)</td><td>8725 (69.6)</td><td>706</td></tr><tr><td>Many women use it</td><td>Pill</td><td>8361 (89.3)</td><td>82 (0.9)</td><td>920 (9.8)</td><td>81</td><td>Pill</td><td>7455 (81.3)</td><td>256 (2.8)</td><td>1454 (15.8)</td><td>178</td></tr><tr><td></td><td>Patch</td><td>413 (27.4)</td><td>185 (12.3)</td><td>910 (60.3)</td><td>41</td><td>Patch</td><td>1744 (10.6)</td><td>4154 (25.2)</td><td>10584 (64.2)</td><td>756</td></tr><tr><td></td><td>Ring</td><td>1316 (24.4)</td><td>706 (13.1)</td><td>3379 (62.6)</td><td>139</td><td>Ring</td><td>1310 (10.4)</td><td>2756 (21.9)</td><td>8514 (67.7)</td><td>667</td></tr></table>
f3adf4dde63853b1ab85973741b2f424ccf62ab57974289d8820c16807e5625c.png
simple
<table><tr><td>Secure environment (SE) employment type</td><td>Less than 10 years</td><td>11 &#8211; 20 years</td><td>21 &#8211; 30 years</td><td>Over 30 years</td><td>TOTAL</td></tr><tr><td>GPs predominantly employed in SE</td><td>3</td><td>8</td><td>8</td><td>4</td><td>23</td></tr><tr><td>GP principals</td><td>1</td><td>2</td><td>4</td><td>2</td><td>9</td></tr><tr><td>TOTAL</td><td>4</td><td>10</td><td>12</td><td>6</td><td>32</td></tr></table>
<table><tr><td>Secure environment (SE) employment type</td><td>Less than 10 years</td><td>11 – 20 years</td><td>21 – 30 years</td><td>Over 30 years</td><td>TOTAL</td></tr><tr><td>GPs predominantly employed in SE</td><td>3</td><td>8</td><td>8</td><td>4</td><td>23</td></tr><tr><td>GP pr</td><td>1</td><td></td><td>4</td><td></td><td>9</td></tr></table>
<table><tr><td>Secure environment (SE) employment type</td><td>Less than 10 years</td><td>11 – 20 years</td><td>21 – 30 years</td><td>Over 30 years</td><td>TOTAL</td></tr><tr><td>incipals</td><td></td><td>2</td><td></td><td>2</td><td></td></tr><tr><td>TOTAL</td><td>4</td><td>10</td><td>12</td><td>6</td><td>32</td></tr></table>
3a26a239d2375f48d08d773e33a10816e08b0b779ab52eae6009279f89729d78.png
complex
<table><tr><td></td><td>National sponsors</td><td>International sponsors</td></tr><tr><td>When to report adverse events</td><td>Frequency</td><td>Frequency</td></tr><tr><td colspan="3">Serious adverse events</td></tr><tr><td> No later than 1 hour</td><td>0</td><td>0</td></tr><tr><td> No later than 24 hours</td><td>0</td><td>31</td></tr><tr><td> No later than 7 days</td><td>1</td><td>2</td></tr><tr><td> No later than 15 days</td><td>0</td><td>1</td></tr><tr><td> Others</td><td>0</td><td>5</td></tr><tr><td> Did not specify</td><td>30</td><td>32</td></tr><tr><td> Total</td><td>31</td><td>71</td></tr><tr><td colspan="3">Unexpected adverse events</td></tr><tr><td> No later than 1 hour</td><td>0</td><td>1</td></tr><tr><td> No later than 24 hours</td><td>0</td><td>12</td></tr><tr><td> No later than 7 days</td><td>1</td><td>1</td></tr><tr><td> No later than 15 days</td><td>0</td><td>3</td></tr><tr><td> Others</td><td>0</td><td>6</td></tr><tr><td> Did not specify</td><td>30</td><td>48</td></tr><tr><td> Total</td><td>31</td><td>71</td></tr></table>
<table><tr><td></td><td>National sponsors</td><td>International sponsors</td></tr><tr><td>When to report adverse events</td><td>Frequency</td><td>Frequency</td></tr><tr><td colspan="3">Serious adverse events</td></tr><tr><td>No later than 1 hour</td><td>0</td><td>0</td></tr><tr><td>No later than 24 hours</td><td>0</td><td>31</td></tr><tr><td>No later than 7 days</td><td>1</td><td>2</td></tr><tr><td>No later than 15 days</td><td>0</td><td>1</td></tr><tr><td>Others</td><td>0</td><td>5</td></tr><tr><td>Did not specify</td><td>30</td><td>32</td></tr><tr><td>Total</td><td>31</td><td>71</td></tr><tr><td colspan="3">Unexpected adverse events</td></tr><tr><td>No later than 1 hour</td><td>0</td><td>1</td></tr><tr><td>No later than 24 hours</td><td>0</td><td>12</td></tr><tr><td>No later than 7 days</td><td>1</td><td>1</td></tr><tr><td>No la</td><td></td><td>3</td></tr></table>
<table><tr><td>ter than 15 days</td><td>0</td><td></td></tr><tr><td>Others</td><td>0</td><td>6</td></tr><tr><td>Did not specify</td><td>30</td><td>48</td></tr><tr><td>Total</td><td>31</td><td>71</td></tr></table>
815f91c399472b63e57e568f3ede972e43cd390dab5ff8704955599f3d8964fa.png
simple
<table><tr><td> </td><td>PCS-36</td><td>MCS-36</td><td>DHI</td><td>HADS</td></tr><tr><td>PCS-36</td><td>1</td><td> </td><td> </td><td> </td></tr><tr><td>MCS-36</td><td>0.22**</td><td>1</td><td> </td><td> </td></tr><tr><td>DHI</td><td>&#8722;0.64***</td><td>&#8722;0.57***</td><td>1</td><td> </td></tr><tr><td>HADS</td><td>&#8722;0.32***</td><td>&#8722;0.82***</td><td>0.58***</td><td>1</td></tr><tr><td>DoD</td><td>0.13</td><td>&#8722;0.09</td><td>&#8722;0.01</td><td>0.004</td></tr><tr><td>FoD</td><td>&#8722;0.20*</td><td>&#8722;0.03</td><td>0.24**</td><td>0.04</td></tr><tr><td>AvP</td><td>0.24**</td><td>0.10</td><td>&#8722;0.25**</td><td>&#8722;0.07</td></tr><tr><td>VNV<sup>a</sup></td><td>F = 7.94***</td><td>4.64*</td><td>5.65**</td><td>5.18**</td></tr><tr><td>Age</td><td>&#8722;0.03</td><td>0.01</td><td>0.004</td><td>&#8722;0.02</td></tr><tr><td>Gender</td><td>0.03</td><td>0.13</td><td>&#8722;0.12</td><td>&#8722;0.03</td></tr></table>
<table><tr><td></td><td>PCS-36</td><td>MCS-36</td><td>DHI</td><td>HADS</td></tr><tr><td>PCS-36</td><td>1</td><td></td><td></td><td></td></tr><tr><td>MCS-36</td><td>0.22**</td><td>1</td><td></td><td></td></tr><tr><td>DHI</td><td>−0.64***</td><td>−0.57***</td><td>1</td><td></td></tr><tr><td>HADS</td><td>−0.32***</td><td>−0.82***</td><td>0.58***</td><td>1</td></tr><tr><td>DoD</td><td>0.13</td><td>−0.09</td><td>−0.01</td><td>0.004</td></tr><tr><td>FoD</td><td>−0.20*</td><td>−0.03</td><td>0.24**</td><td>0.04</td></tr><tr><td>AvP</td><td>0.24**</td><td>0.10</td><td>−0.25**</td><td>−0.07</td></tr><tr><td>VN</td><td>F = 7.9</td><td>4</td><td>5.</td><td>5.1</td></tr></table>
<table><tr><td>Va</td><td>4***</td><td>.64*</td><td>65**</td><td>8**</td></tr><tr><td>Age</td><td>−0.03</td><td>0.01</td><td>0.004</td><td>−0.02</td></tr><tr><td>Gender</td><td>0.03</td><td>0.13</td><td>−0.12</td><td>−0.03</td></tr></table>
0e7bdea765baf1b8c7a4bdd07f8c7f113835c14bffa21e441837ab9452e7f582.png
complex
<table><tr><td></td><td>Mean (SD) or %</td></tr><tr><td>Age, mean (SD)</td><td>63.5 (13.8)</td></tr><tr><td> 18&#8211;45, %</td><td>11.5%</td></tr><tr><td> 46&#8211;70, %</td><td>51.5%</td></tr><tr><td>&#8805; 71, %</td><td>37.0%</td></tr><tr><td>Male, %</td><td>35.3%</td></tr><tr><td colspan="2">Marital status, %</td></tr><tr><td> Married</td><td>70.7%</td></tr><tr><td> Single</td><td>3.7%</td></tr><tr><td> Widowed/Separated/divorced</td><td>25.6%</td></tr><tr><td>Living alone, %</td><td>15.2%</td></tr><tr><td colspan="2">Level of education, %</td></tr><tr><td>&#8804; Elementary</td><td>47.9%</td></tr><tr><td> Middle School</td><td>16.7%</td></tr><tr><td> High School</td><td>23.8%</td></tr><tr><td>&#8805; University</td><td>11.7%</td></tr><tr><td colspan="2">Employment status, %</td></tr><tr><td> Regular/long-term</td><td>25.0%</td></tr><tr><td> Non-regular/temporary</td><td>23.5%</td></tr><tr><td> Unemployed</td><td>2.5%</td></tr><tr><td> Economically inactive/students</td><td>50.0%</td></tr><tr><td>Medical aid, %</td><td>8.3%</td></tr><tr><td>Perceived social status</td><td>3.6 (1.5)</td></tr></table>
<table><tr><td></td><td>Mean (SD) or %</td></tr><tr><td>Age, mean (SD)</td><td>63.5 (13.8)</td></tr><tr><td>18–45, %</td><td>11.5%</td></tr><tr><td>46–70, %</td><td>51.5%</td></tr><tr><td>≥ 71, %</td><td>37.0%</td></tr></table>
<table><tr><td>Male, %</td><td>35.3%</td></tr><tr><td colspan="2">Marital status, %</td></tr><tr><td>Married</td><td>70.7%</td></tr><tr><td>Single</td><td>3.7%</td></tr><tr><td>Widowed/Separated/divorced</td><td>25.6%</td></tr><tr><td>Living alone, %</td><td>15.2%</td></tr><tr><td colspan="2">Level of education, %</td></tr><tr><td>≤ Elementary</td><td>47.9%</td></tr><tr><td>Middle School</td><td>16.7%</td></tr><tr><td>High School</td><td>23.8%</td></tr><tr><td>≥ University</td><td>11.7%</td></tr><tr><td colspan="2">Employment status, %</td></tr><tr><td>Regular/long-term</td><td>25.0%</td></tr><tr><td>Non-regular/temporary</td><td>23.5%</td></tr><tr><td>Unemployed</td><td>2.5%</td></tr><tr><td>Economically inactive/students</td><td>50.0%</td></tr><tr><td>Medical aid, %</td><td>8.3%</td></tr><tr><td>Perceived social status</td><td>3.6 (1.5)</td></tr></table>
fbc027376222fccd528adfc39bb9198a00aa41c99d46c2fdf2ec919fe20622df.png
complex
<table><tr><td>Group</td><td>HC (n = 21)</td><td>Mild AD (n = 17)</td><td>AD-MCI (n = 23)</td><td><i>p</i></td></tr><tr><td>Female</td><td>13</td><td>7</td><td>11</td><td rowspan="2">0.42</td></tr><tr><td>Male</td><td>8</td><td>10</td><td>12</td></tr><tr><td>Age</td><td>66.4 &#177; 7.5</td><td>68.9 &#177; 8.1</td><td>67.6 &#177; 5.4</td><td>0.53</td></tr><tr><td>MMSE score</td><td>29.4 &#177; 0.8</td><td>22.1 &#177; 4.3</td><td>26.8 &#177; 2.0</td><td>&lt;0.01</td></tr><tr><td>Delayed recall (CERAD)</td><td>6.5 &#177; 2.1</td><td>0.9 &#177; 1.8</td><td>3.1 &#177; 2.0</td><td>&lt;0.01</td></tr></table>
<table><tr><td>Group</td><td>HC (n = 21)</td><td>Mild AD (n = 17)</td><td>AD-MCI (n = 23)</td><td>p</td></tr><tr><td>Female</td><td>13</td><td>7</td><td>11</td><td rowspan="2">0.42</td></tr><tr><td>Male</td><td>8</td><td>10</td><td>12</td></tr></table>
<table><tr><td>Group</td><td>HC (n = 21)</td><td>Mild AD (n = 17)</td><td>AD-MCI (n = 23)</td><td>p</td></tr><tr><td>Age</td><td>66.4 ± 7.5</td><td>68.9 ± 8.1</td><td>67.6 ± 5.4</td><td>0.53</td></tr><tr><td>MMSE score</td><td>29.4 ± 0.8</td><td>22.1 ± 4.3</td><td>26.8 ± 2.0</td><td><0.01</td></tr><tr><td>Delayed recall (CERAD)</td><td>6.5 ± 2.1</td><td>0.9 ± 1.8</td><td>3.1 ± 2.0</td><td><0.01</td></tr></table>
4f5f502a5db3457b4c54f13e4c9cd7f76e409262e57da5897a3fb3000c58d171.png
complex
<table><tr><td colspan="2">Clinical features</td><td colspan="2">Pathoanatomy</td><td colspan="2">Treatment based approach</td><td colspan="2">Screening/Prediction tool</td><td colspan="2">Pain mechanisms</td></tr><tr><td>Barker 1990 [79]</td><td>2</td><td>Bernard and Kirkaldy Willis 1987 [41]</td><td>2</td><td>Albert et al. 2012 [61]</td><td>4</td><td>Fritz et al. 2007 [64]</td><td>3</td><td>Schafer et al. 2009 [65]</td><td>5</td></tr><tr><td>Ben Debba et al. 2000 [36]</td><td>3.5</td><td>Cassisi et al. 1993 [38]</td><td>3</td><td>Hall et al. 1994 [49]</td><td>5</td><td>Roach et al. 1997 [63]</td><td>3</td><td>Smart et al. 2011 [66]</td><td>5</td></tr><tr><td>Glassman et al. 2011 [37]</td><td>2.5</td><td>Hahne et al. 2011 [38]</td><td>3</td><td>Mckenzie 1981 [49]</td><td>5.5</td><td>Scholz et al. 2009 [62]</td><td>4</td><td>Nijs et al. 2015 [75]</td><td>2.5</td></tr><tr><td>Nachemson and Andersson 1982 [80]</td><td>3.5</td><td>Paatelma et al. 2009 [44]</td><td>3.5</td><td>Delitto et al. 2012 [48]</td><td>3.5</td><td></td><td></td><td></td><td></td></tr><tr><td>Spitzer et al. 1987 [25]</td><td>4</td><td>Petersen et al. 2003 [39]</td><td>4</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Sweetman et al. 1992 [26]</td><td>2.5</td><td>Vining et al. 2013 [46]</td><td>3.5</td><td></td><td></td><td></td><td></td><td></td><td></td></tr></table>
<table><tr><td colspan="2">Clinical features</td><td colspan="2">Pathoanatomy</td><td colspan="2">Treatment based approach</td><td colspan="2">Screening/Prediction tool</td><td colspan="2">Pain mechanisms</td></tr><tr><td></td><td></td><td>Bernard </td><td>2</td><td></td><td>4</td><td></td><td>3</td><td>Schafer e</td><td>5</td></tr></table>
<table><tr><td>Barker 1990 [79]</td><td>2</td><td>and Kirkaldy Willis 1987 [41]</td><td></td><td>Albert et al. 2012 [61]</td><td></td><td>Fritz et al. 2007 [64]</td><td></td><td>t al. 2009 [65]</td><td></td></tr><tr><td>Ben Debba et al. 2000 [36]</td><td>3.5</td><td>Cassisi et al. 1993 [38]</td><td>3</td><td>Hall et al. 1994 [49]</td><td>5</td><td>Roach et al. 1997 [63]</td><td>3</td><td>Smart et al. 2011 [66]</td><td>5</td></tr><tr><td>Glassman et al. 2011 [37]</td><td>2.5</td><td>Hahne et al. 2011 [38]</td><td>3</td><td>Mckenzie 1981 [49]</td><td>5.5</td><td>Scholz et al. 2009 [62]</td><td>4</td><td>Nijs et al. 2015 [75]</td><td>2.5</td></tr><tr><td>Nachemson and Andersson 1982 [80]</td><td>3.5</td><td>Paatelma et al. 2009 [44]</td><td>3.5</td><td>Delitto et al. 2012 [48]</td><td>3.5</td><td></td><td></td><td></td><td></td></tr><tr><td>Spitzer et al. 1987 [25]</td><td>4</td><td>Petersen et al. 2003 [39]</td><td>4</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Sweetman et al. 1992 [26]</td><td>2.5</td><td>Vining et al. 2013 [46]</td><td>3.5</td><td></td><td></td><td></td><td></td><td></td><td></td></tr></table>
06cc524159589d1a0e0ff7fc174c0e67d71a8445c8555edee4ca38071a123b37.png
simple
<table><tr><td>Gene</td><td>Primer</td><td>Sequence</td><td>Amplicon</td><td>Tm (&#176;C)</td></tr><tr><td>GK</td><td>Forward</td><td>5&#8242;-CATATGTGCTCCGCAGGACTA-3&#8242;</td><td>105 bp</td><td>61.7</td></tr><tr><td></td><td>Reverse</td><td>5&#8242;-CTTGTACACGGAGCCATCCA-3&#8242;</td><td></td><td></td></tr><tr><td>HK</td><td>Forward</td><td>5&#8242;-ACCCACGAAACAACACCATCA-3&#8242;</td><td>69 bp</td><td>79</td></tr><tr><td></td><td>Reverse</td><td>5&#8242;-GACGTACAACAATGGCTCACTAAAG-3&#8242;</td><td></td><td></td></tr><tr><td>PFK-1 (L)</td><td>Forward</td><td>5&#8242;-TTACCGATCACCCTCGTTCCT-3&#8242;</td><td>80 bp</td><td>84</td></tr><tr><td></td><td>Reverse</td><td>5&#8242;-TTCCCCTTAGTGCTGGGATCT-3&#8242;</td><td></td><td></td></tr><tr><td>PFK-1 (M)</td><td>Forward</td><td>5&#8242;-GTGGACACTGATATGACCATTGG-3&#8242;</td><td>67 bp</td><td>82</td></tr><tr><td></td><td>Reverse</td><td>5&#8242;-ATGGCGTCCACGATCTCTACA-3&#8242;</td><td></td><td></td></tr><tr><td>G6Pase</td><td>Forward</td><td>5&#8242;-GGATCTACCTTGCGGCTCACT-3&#8242;</td><td>132 bp</td><td>62.7</td></tr><tr><td></td><td>Reverse</td><td>5&#8242;-TGTAGATGCCCCGGATGTG-3&#8242;</td><td></td><td></td></tr><tr><td>F16BP</td><td>Forward</td><td>5&#8242;-CGTCCTATGCTACCTGTGTCCTT-3&#8242;</td><td>73 bp</td><td>81</td></tr><tr><td></td><td>Reverse</td><td>5&#8242;-CCCCTCTTCTCGGGCTCTATTAT-3&#8242;</td><td></td><td></td></tr><tr><td>PEPCK</td><td>Forward</td><td>5&#8242;-GCAACTTCTCTCGGCTCGTT-3&#8242;</td><td>99 bp</td><td>62.7</td></tr><tr><td></td><td>Reverse</td><td>5&#8242;-TGGCAGTTCTACTGGGCTACAC-3&#8242;</td><td></td><td></td></tr><tr><td>G6PDH</td><td>Forward</td><td>5&#8242;-GATGGCCTTCTACCCGAAGAC-3&#8242;</td><td>72 bp</td><td>82</td></tr><tr><td></td><td>Reverse</td><td>5&#8242;-GCGGATGTCATCCACTGTGA-3&#8242;</td><td></td><td></td></tr><tr><td>P13K</td><td>Forward</td><td>5&#8242;-CCTGAAAGAGCTGGTGCTACATT-3&#8242;</td><td>71 bp</td><td>81</td></tr><tr><td></td><td>Reverse</td><td>5&#8242;-GTGTGACATTGAGGGAGTCATTG-3&#8242;</td><td></td><td></td></tr></table>
<table><tr><td>Gene</td><td>Primer</td><td>Sequence</td><td>Amplicon</td><td>Tm (°C)</td></tr><tr><td>GK</td><td>Forward</td><td>5′-CATATGTGCTCCGCAGGACTA-3′</td><td>105 bp</td><td>61.7</td></tr><tr><td></td><td>Reverse</td><td>5′-CTTGTACACGGAGCCATCCA-3′</td><td></td><td></td></tr><tr><td>HK</td><td>Forward</td><td>5′-ACCCACGAAACAACACCATCA-3′</td><td>69 bp</td><td>79</td></tr><tr><td></td><td>Reverse</td><td>5′-GACGTACAACAATGGCTCACTAAAG-3′</td><td></td><td></td></tr><tr><td>PFK-1 (L)</td><td>Forward</td><td>5′-TTACCGATCACCCTCGTTCCT-3′</td><td>80 bp</td><td>84</td></tr><tr><td></td><td>Reverse</td><td>5′-TTCCCCTTAGTGCTGGGATCT-3′</td><td></td><td></td></tr><tr><td>PFK-1 (M)</td><td>Forward</td><td>5′-GTGGACACTGATATGACCATTGG-3′</td><td>67 bp</td><td>82</td></tr><tr><td></td><td>Reverse</td><td>5′-ATGGCGTCCACGATCTCTACA-3′</td><td></td><td></td></tr><tr><td>G6Pase</td><td>Forward</td><td>5′-GGATCTACCTTGCGGCTCACT-3′</td><td>132 bp</td><td>62.7</td></tr><tr><td></td><td>Rev</td><td>5′-TGTAGATGC</td><td></td><td></td></tr></table>
<table><tr><td></td><td>erse</td><td>CCCGGATGTG-3′</td><td></td><td></td></tr><tr><td>F16BP</td><td>Forward</td><td>5′-CGTCCTATGCTACCTGTGTCCTT-3′</td><td>73 bp</td><td>81</td></tr><tr><td></td><td>Reverse</td><td>5′-CCCCTCTTCTCGGGCTCTATTAT-3′</td><td></td><td></td></tr><tr><td>PEPCK</td><td>Forward</td><td>5′-GCAACTTCTCTCGGCTCGTT-3′</td><td>99 bp</td><td>62.7</td></tr><tr><td></td><td>Reverse</td><td>5′-TGGCAGTTCTACTGGGCTACAC-3′</td><td></td><td></td></tr><tr><td>G6PDH</td><td>Forward</td><td>5′-GATGGCCTTCTACCCGAAGAC-3′</td><td>72 bp</td><td>82</td></tr><tr><td></td><td>Reverse</td><td>5′-GCGGATGTCATCCACTGTGA-3′</td><td></td><td></td></tr><tr><td>P13K</td><td>Forward</td><td>5′-CCTGAAAGAGCTGGTGCTACATT-3′</td><td>71 bp</td><td>81</td></tr><tr><td></td><td>Reverse</td><td>5′-GTGTGACATTGAGGGAGTCATTG-3′</td><td></td><td></td></tr></table>
5360415ac31cebad1ee4406f62f2e344dfa4598bd798676128eaf39f8df1e1db.png
simple
<table><tr><td>Sampling time (expression change)</td><td>Ischemia-related</td><td>PACAP-related</td><td>PACAP in ischemia-related</td><td>Common: ischemia-related and PACAP in ischemia-related</td><td>Common: PACAP-related and PACAP in ischemia-related</td></tr><tr><td>6 h (upregulated)</td><td>1,237</td><td>435</td><td>839</td><td>171</td><td>43</td></tr><tr><td>6 h (downregulated)</td><td>622</td><td>743</td><td>498</td><td>31</td><td>24</td></tr><tr><td>24 h (upregulated)</td><td>2,759</td><td>263</td><td>831</td><td>49</td><td>30</td></tr><tr><td>24 h (downregulated)</td><td>2,104</td><td>271</td><td>1468</td><td>28</td><td>75</td></tr></table>
<table><tr><td>Sampling time (expression change)</td><td>Ischemia-related</td><td>PACAP-related</td><td>PACAP in ischemia-related</td><td>Common: ischemia-related and PACAP in ischemia-related</td><td>Common: PACAP-related and PACAP in ischemia-related</td></tr></table>
<table><tr><td>6 h (upregulated)</td><td>1,237</td><td>435</td><td>839</td><td>171</td><td>43</td></tr><tr><td>6 h (downregulated)</td><td>622</td><td>743</td><td>498</td><td>31</td><td>24</td></tr><tr><td>24 h (upregulated)</td><td>2,759</td><td>263</td><td>831</td><td>49</td><td>30</td></tr><tr><td>24 h (downregulated)</td><td>2,104</td><td>271</td><td>1468</td><td>28</td><td>75</td></tr></table>
e91c87bfdbb0b40ba0af9173809a700f9e249ea8640b6f259aea55d6d6192548.png
simple
<table><tr><td></td><td>JIA-associated NIU (n = 14)</td><td>Pure NIU (n = 11)</td><td>Total</td></tr><tr><td>Bilateral (pts)</td><td>12/14</td><td>11/11</td><td>23/25</td></tr><tr><td>Total eyes with NIU</td><td>24</td><td>22</td><td>46</td></tr><tr><td>Location:</td><td></td><td></td><td></td></tr><tr><td>Anterior/Posterior/Panuveitis</td><td>12/6/2</td><td>2/4/2</td><td>16/7/2</td></tr></table>
<table><tr><td></td><td>JIA-associated NIU (n = 14)</td><td>Pure NIU (n = 11)</td><td>Total</td></tr><tr><td>Bilateral (pts)</td><td>12/14</td><td>11/11</td><td>23/25</td></tr></table>
<table><tr><td>Total eyes with NIU</td><td>24</td><td>22</td><td>46</td></tr><tr><td>Location:</td><td></td><td></td><td></td></tr><tr><td>Anterior/Posterior/Panuveitis</td><td>12/6/2</td><td>2/4/2</td><td>16/7/2</td></tr></table>
e88c1d26806fba26d5897ac367de5d965f0c3dbea4108d874b4abd6214aa7170.png
complex
<table><tr><td colspan="2">Nutrients</td><td>Number of Foods</td><td>Energy</td><td>Saturated Fatty Acids</td><td>Cholesterol</td><td>Na</td><td>Total Sugar</td><td>Added Sugars</td><td>Ca</td><td>Vitamin D</td><td>K</td><td>Fiber</td></tr><tr><td colspan="2">Units of Nutrient Intake</td><td></td><td>Kcal</td><td>g</td><td>Mg</td><td>mg</td><td>g</td><td>g</td><td>mg</td><td>&#956;g</td><td>mg</td><td>g</td></tr><tr><td rowspan="2">All foods</td><td>Mean intake</td><td>15.1 (0.2)</td><td>2064 (23)</td><td>27.4 (0.4)</td><td>221.4 (4.8)</td><td>3176 (55)</td><td>142.5 (1.9)</td><td>92.7 (1.9)</td><td>1059 (17)</td><td>5.9 (0.2)</td><td>12.8 (0.2)</td><td>12.8 (0.2)</td></tr><tr><td>% contribution <sup>b,c</sup></td><td>100</td><td>100</td><td>100</td><td>100</td><td>100</td><td>100</td><td>100</td><td>100</td><td>100</td><td>100</td><td>100</td></tr><tr><td rowspan="2">IFIC category foods <sup>d</sup></td><td>Mean intake</td><td>11.7 (0.2)</td><td>1457 (22)</td><td>18.6 (0.4)</td><td>152.3 (3.8)</td><td>2133 (45)</td><td>111.0 (2.0)</td><td>69.3 (1.7)</td><td>795 (19)</td><td>4.9 (0.2)</td><td>9.3 (0.2)</td><td>9.3 (0.2)</td></tr><tr><td>% contribution <sup>b,c</sup></td><td>77.8 (0.8)</td><td>70.6 (0.9)</td><td>67.8 (1.1)</td><td>68.8 (1.2)</td><td>67.2 (1.1)</td><td>77.9 (0.8)</td><td>74.8 (0.9)</td><td>75.1 (1.2)</td><td>84.1 (1.4)</td><td>72.2 (1.0)</td><td>72.2 (1.0)</td></tr><tr><td rowspan="2">1. Minimally processed foods</td><td>Mean intake</td><td>3.4 (0.1)</td><td>252 (9)</td><td>4.3 (0.2)</td><td>64.6 (3.0)</td><td>250 (10)</td><td>20.4 (0.7)</td><td>1.3 (0.3)</td><td>333 (12)</td><td>3.2 (0.1)</td><td>1.9 (0.1)</td><td>1.9 (0.1)</td></tr><tr><td>% contribution <sup>b,c</sup></td><td>22.8 (0.5)</td><td>12.2 (0.4)</td><td>15.5 (0.6)</td><td>29.2 (1.2)</td><td>7.9 (0.3)</td><td>14.3 (0.5)</td><td>1.4 (0.3)</td><td>31.4 (0.9)</td><td>54.1 (1.4)</td><td>14.8 (0.6)</td><td>14.8 (0.6)</td></tr><tr><td rowspan="2">2. Foods processed for preservation</td><td>Mean intake</td><td>0.6 (0.0)</td><td>59 (2)</td><td>0.1 (0.0)</td><td>0.4 (0.1)</td><td>36 (3)</td><td>11.1 (0.5)</td><td>0.6 (0.1)</td><td>34 (3)</td><td>0.1 (0.0)</td><td>0.6 (0.0)</td><td>0.6 (0.0)</td></tr><tr><td>% contribution <sup>b,c</sup></td><td>3.9 (0.1)</td><td>2.8 (0.1)</td><td>0.3 (0.1)</td><td>0.2 (0.0)</td><td>1.1 (0.1)</td><td>7.8 (0.4)</td><td>0.6 (0.1)</td><td>3.2 (0.2)</td><td>1.0 (0.2)</td><td>5.0 (0.3)</td><td>5.0 (0.3)</td></tr><tr><td rowspan="2">3. Mixtures of combined ingredients</td><td>Mean intake</td><td>2.5 (0.1)</td><td>298 (9)</td><td>3.9 (0.2)</td><td>27.5 (1.5)</td><td>604 (18)</td><td>11.8 (0.5)</td><td>8.9 (0.5)</td><td>154 (5)</td><td>0.3 (0.0)</td><td>2.0 (0.1)</td><td>2.0 (0.1)</td></tr><tr><td>% contribution <sup>b,c</sup></td><td>16.4 (0.3)</td><td>14.4 (0.4)</td><td>14.2 (0.5)</td><td>12.4 (0.6)</td><td>19.0 (0.6)</td><td>8.3 (0.4)</td><td>9.6 (0.5)</td><td>14.5 (0.5)</td><td>5.0 (0.3)</td><td>15.9 (0.7)</td><td>15.9 (0.7)</td></tr><tr><td rowspan="2">4. Ready-to-eat processed foods</td><td>Mean intake</td><td>5.0 (0.1)</td><td>751 (16)</td><td>8.8 (0.3)</td><td>45.8 (1.7)</td><td>1007 (25)</td><td>66.6 (2.0)</td><td>58.1 (1.8)</td><td>236 (9)</td><td>1.3 (0.1)</td><td>4.1 (0.1)</td><td>4.1 (0.1)</td></tr><tr><td>% contribution <sup>b,c</sup></td><td>32.9 (0.6)</td><td>36.4 (0.8)</td><td>32.1 (0.9)</td><td>20.7 (0.8)</td><td>31.7 (0.8)</td><td>46.7 (1.1)</td><td>62.7 (1.2)</td><td>22.2 (0.7)</td><td>22.7 (1.0)</td><td>31.9 (0.9)</td><td>31.9 (0.9)</td></tr><tr><td rowspan="2">5. Prepared foods/meals</td><td>Mean intake</td><td>0.3 (0.0)</td><td>98 (7)</td><td>1.6 (0.1)</td><td>14.0 (1.2)</td><td>236 (19)</td><td>1.1 (0.1)</td><td>0.5 (0.1)</td><td>39 (4)</td><td>0.1 (0.0)</td><td>0.6 (0.1)</td><td>0.6 (0.1)</td></tr><tr><td>% contribution <sup>b,c</sup></td><td>1.7 (0.1)</td><td>4.7 (0.3)</td><td>5.7 (0.4)</td><td>6.3 (0.5)</td><td>7.4 (0.5)</td><td>0.8 (0.1)</td><td>0.5 (0.1)</td><td>3.7 (0.4)</td><td>1.3 (0.2)</td><td>4.6 (0.4)</td><td>4.6 (0.4)</td></tr><tr><td rowspan="2">Foods from restaurants/Cafeterias</td><td>Mean intake</td><td>3.4 (0.1)</td><td>608 (22)</td><td>8.8 (0.3)</td><td>69.2 (3.4)</td><td>1042 (44)</td><td>31.5 (1.2)</td><td>23.4 (0.9)</td><td>263 (13)</td><td>0.9 (0.1)</td><td>3.6 (0.1)</td><td>3.6 (0.1)</td></tr><tr><td>% contribution <sup>b,c</sup></td><td>22.2 (0.8)</td><td>29.4 (0.9)</td><td>32.2 (1.1)</td><td>31.2 (1.2)</td><td>32.8 (1.1)</td><td>22.1 (0.8)</td><td>25.2 (0.9)</td><td>24.9 (1.2)</td><td>15.9 (1.4)</td><td>27.8 (1.0)</td><td>27.8 (1.0)</td></tr></table>
<table><tr><td colspan="2">Nutrients</td><td>Number of Foods</td><td>Energy</td><td>Saturated Fatty Acids</td><td>Cholesterol</td><td>Na</td><td>Total Sugar</td><td>Added Sugars</td><td>Ca</td><td>Vitamin D</td><td>K</td><td>Fiber</td></tr><tr><td colspan="2">Units of Nutrient Intake</td><td></td><td>Kcal</td><td>g</td><td>Mg</td><td>mg</td><td>g</td><td>g</td><td>mg</td><td>μg</td><td>mg</td><td>g</td></tr><tr><td rowspan="2">All foods</td><td>Mean intake</td><td>15.1 (0.2)</td><td>2064 (23)</td><td>27.4 (0.4)</td><td>221.4 (4.8)</td><td>3176 (55)</td><td>142.5 (1.9)</td><td>92.7 (1.9)</td><td>1059 (17)</td><td>5.9 (0.2)</td><td>12.8 (0.2)</td><td>12.8 (0.2)</td></tr><tr><td>% contribution b,c</td><td>100</td><td>100</td><td>100</td><td>100</td><td>100</td><td>100</td><td>100</td><td>100</td><td>100</td><td>100</td><td>100</td></tr><tr><td rowspan="2">IFIC category foods d</td><td>Mean intake</td><td>11.7 (0.2)</td><td>1457 (22)</td><td>18.6 (0.4)</td><td>152.3 (3.8)</td><td>2133 (45)</td><td>111.0 (2.0)</td><td>69.3 (1.7)</td><td>795 (19)</td><td>4.9 (0.2)</td><td>9.3 (0.2)</td><td>9.3 (0.2)</td></tr><tr><td>% contribution b,c</td><td>77.8 (0.8)</td><td>70.6 (0.9)</td><td>67.8 (1.1)</td><td>68.8 (1.2)</td><td>67.2 (1.1)</td><td>77.9 (0.8)</td><td>74.8 (0.9)</td><td>75.1 (1.2)</td><td>84.1 (1.4)</td><td>72.2 (1.0)</td><td>72.2 (1.0)</td></tr><tr><td rowspan="2">1. Minimally processed foods</td><td>Mean intake</td><td>3.4 (0.1)</td><td>252 (9)</td><td>4.3 (0.2)</td><td>64.6 (3.0)</td><td>250 (10)</td><td>20.4 (0.7)</td><td>1.3 (0.3)</td><td>333 (12)</td><td>3.2 (0.1)</td><td>1.9 (0.1)</td><td>1.9 (0.1)</td></tr><tr><td>% contribution b,c</td><td>22.8 (0.5)</td><td>12.2 (0.4)</td><td>15.5 (0.6)</td><td>29.2 (1.2)</td><td>7.9 (0.3)</td><td>14.3 (0.5)</td><td>1.4 (0.3)</td><td>31.4 (0.9)</td><td>54.1 (1.4)</td><td>14.8 (0.6)</td><td>14.8 (0.6)</td></tr><tr><td rowspan="2">2. Foods processed for preservation</td><td>Mean intake</td><td>0.6 (0.0)</td><td>59 (2)</td><td>0.1 (0.0)</td><td>0.4 (0.1)</td><td>36 (3)</td><td>11.1 (0.5)</td><td>0.6 (0.1)</td><td>34 (3)</td><td>0.1 (0.0)</td><td>0.6 (0.0)</td><td>0.6 (0.0)</td></tr><tr><td>% contribution b,c</td><td>3.9 (0.1)</td><td>2.8 (0.1)</td><td>0.3 (0.1)</td><td>0.2 (0.0)</td><td>1.1 (0.1)</td><td>7.8 (0.4)</td><td>0.6 (0.1)</td><td>3.2 (0.2)</td><td>1.0 (0.2)</td><td>5.0 (0.3)</td><td>5.0 (0.3)</td></tr><tr><td rowspan="2">3. Mixtures of combined ingredients</td><td>Mean intake</td><td>2.5 (0.1)</td><td>298 (9)</td><td>3.9 (0.2)</td><td>27.5 (1.5)</td><td>604 (18)</td><td>11.8 (0.5)</td><td>8.9 (0.5)</td><td>154 (5)</td><td>0.3 (0.0)</td><td>2.0 (0.1)</td><td>2.0 (0.1)</td></tr><tr><td>% contribution b,c</td><td>16.4 (0.3)</td><td>14.4 (0.4)</td><td>14.2 (0.5)</td><td>12.4 (0.6)</td><td>19.0 (0.6)</td><td>8.3 (0.4)</td><td>9.6 (0.5)</td><td>14.5 (0.5)</td><td>5.0 (0.3)</td><td>15.9 (0.7)</td><td>15.9 (0.7)</td></tr><tr><td>4. Rea</td><td>Mean intake</td><td>5.0</td><td></td><td>8.</td><td>45.</td><td>1</td><td>66</td><td>58.1 (</td><td>236</td><td>1.3 </td><td></td><td>4.</td></tr></table>
<table><tr><td colspan="2">Nutrients</td><td>Number of Foods</td><td>Energy</td><td>Saturated Fatty Acids</td><td>Cholesterol</td><td>Na</td><td>Total Sugar</td><td>Added Sugars</td><td>Ca</td><td>Vitamin D</td><td>K</td><td>Fiber</td></tr><tr><td colspan="2">Units of Nutrient Intake</td><td></td><td>Kcal</td><td>g</td><td>Mg</td><td>mg</td><td>g</td><td>g</td><td>mg</td><td>μg</td><td>mg</td><td>g</td></tr><tr><td rowspan="2">dy-to-eat processed foods</td><td></td><td> (0.1)</td><td>751 (16)</td><td>8 (0.3)</td><td>8 (1.7)</td><td>007 (25)</td><td>.6 (2.0)</td><td>1.8)</td><td> (9)</td><td>(0.1)</td><td>4.1 (0.1)</td><td>1 (0.1)</td></tr><tr><td>% contribution b,c</td><td>32.9 (0.6)</td><td>36.4 (0.8)</td><td>32.1 (0.9)</td><td>20.7 (0.8)</td><td>31.7 (0.8)</td><td>46.7 (1.1)</td><td>62.7 (1.2)</td><td>22.2 (0.7)</td><td>22.7 (1.0)</td><td>31.9 (0.9)</td><td>31.9 (0.9)</td></tr><tr><td rowspan="2">5. Prepared foods/meals</td><td>Mean intake</td><td>0.3 (0.0)</td><td>98 (7)</td><td>1.6 (0.1)</td><td>14.0 (1.2)</td><td>236 (19)</td><td>1.1 (0.1)</td><td>0.5 (0.1)</td><td>39 (4)</td><td>0.1 (0.0)</td><td>0.6 (0.1)</td><td>0.6 (0.1)</td></tr><tr><td>% contribution b,c</td><td>1.7 (0.1)</td><td>4.7 (0.3)</td><td>5.7 (0.4)</td><td>6.3 (0.5)</td><td>7.4 (0.5)</td><td>0.8 (0.1)</td><td>0.5 (0.1)</td><td>3.7 (0.4)</td><td>1.3 (0.2)</td><td>4.6 (0.4)</td><td>4.6 (0.4)</td></tr><tr><td rowspan="2">Foods from restaurants/Cafeterias</td><td>Mean intake</td><td>3.4 (0.1)</td><td>608 (22)</td><td>8.8 (0.3)</td><td>69.2 (3.4)</td><td>1042 (44)</td><td>31.5 (1.2)</td><td>23.4 (0.9)</td><td>263 (13)</td><td>0.9 (0.1)</td><td>3.6 (0.1)</td><td>3.6 (0.1)</td></tr><tr><td>% contribution b,c</td><td>22.2 (0.8)</td><td>29.4 (0.9)</td><td>32.2 (1.1)</td><td>31.2 (1.2)</td><td>32.8 (1.1)</td><td>22.1 (0.8)</td><td>25.2 (0.9)</td><td>24.9 (1.2)</td><td>15.9 (1.4)</td><td>27.8 (1.0)</td><td>27.8 (1.0)</td></tr></table>
b9969297e70bffd261bc626bbb75d78e852a2d4b3b4af84755c9cd3ad62a08a6.png
simple
<table><tr><td>Reference</td><td>Strains</td><td>Plasmids</td><td>Time (h)</td><td>IPTG-conc. (mM)</td><td>RPM (1/min)</td><td>Temperature (&#176;C)</td><td>&#948;-ALA-conc. (mM)</td><td>Thiamin-conc. (mM)</td></tr><tr><td>[46]</td><td>BL21(DE3)</td><td>pET28a</td><td>2</td><td>0.2</td><td></td><td>25</td><td></td><td></td></tr><tr><td></td><td></td><td></td><td>4</td><td>0.5</td><td></td><td>30</td><td></td><td></td></tr><tr><td></td><td></td><td></td><td>6</td><td>0.8</td><td></td><td>34</td><td></td><td></td></tr><tr><td></td><td></td><td></td><td>8</td><td>1</td><td></td><td>37</td><td></td><td></td></tr><tr><td></td><td></td><td></td><td>10</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>[49]</td><td>JM109</td><td>pCWori</td><td>12</td><td>0.2</td><td>150</td><td>18</td><td>0.2</td><td>0.5</td></tr><tr><td></td><td>DH5&#945;</td><td>pET28a</td><td>20</td><td>0.4</td><td>170</td><td>25</td><td>0.4</td><td>1</td></tr><tr><td></td><td>C100</td><td>pTreHis</td><td>24</td><td>0.6</td><td>200</td><td>30</td><td>0.6</td><td>1.5</td></tr><tr><td></td><td>DE3</td><td></td><td>30</td><td>0.8</td><td>250</td><td>37</td><td>0.8</td><td></td></tr><tr><td></td><td>CodonPlus</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td>Pril</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr></table>
<table><tr><td>Reference</td><td>Strains</td><td>Plasmids</td><td>Time (h)</td><td>IPTG-conc. (mM)</td><td>RPM (1/min)</td><td>Temperature (°C)</td><td>δ-ALA-conc. (mM)</td><td>Thiamin-conc. (mM)</td></tr><tr><td>[46]</td><td>BL21(DE3)</td><td>pET28a</td><td>2</td><td>0.2</td><td></td><td>25</td><td></td><td></td></tr><tr><td></td><td></td><td></td><td>4</td><td>0.5</td><td></td><td>30</td><td></td><td></td></tr><tr><td></td><td></td><td></td><td>6</td><td>0.8</td><td></td><td>34</td><td></td><td></td></tr><tr><td></td><td></td><td></td><td>8</td><td>1</td><td></td><td>37</td><td></td><td></td></tr></table>
<table><tr><td>Reference</td><td>Strains</td><td>Plasmids</td><td>Time (h)</td><td>IPTG-conc. (mM)</td><td>RPM (1/min)</td><td>Temperature (°C)</td><td>δ-ALA-conc. (mM)</td><td>Thiamin-conc. (mM)</td></tr><tr><td></td><td></td><td></td><td>10</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>[49]</td><td>JM109</td><td>pCWori</td><td>12</td><td>0.2</td><td>150</td><td>18</td><td>0.2</td><td>0.5</td></tr><tr><td></td><td>DH5α</td><td>pET28a</td><td>20</td><td>0.4</td><td>170</td><td>25</td><td>0.4</td><td>1</td></tr><tr><td></td><td>C100</td><td>pTreHis</td><td>24</td><td>0.6</td><td>200</td><td>30</td><td>0.6</td><td>1.5</td></tr><tr><td></td><td>DE3</td><td></td><td>30</td><td>0.8</td><td>250</td><td>37</td><td>0.8</td><td></td></tr><tr><td></td><td>CodonPlus</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td>Pril</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr></table>
647a2cb4d3987aab4b52553a3331aa9ab95cf2ceb603dbd87a5838b91f08bbf3.png
complex
<table><tr><td></td><td>Current</td><td colspan="2">Projected</td></tr><tr><td></td><td></td><td>Only MVA<sup>3</sup></td><td>MVA/Misoprostol<sup>4</sup></td></tr><tr><td colspan="4">Procedure type distribution for first trimester, legal, induced abortion</td></tr><tr><td>MVA ($17)</td><td></td><td>100 %</td><td>70 %</td></tr><tr><td>Misoprostol-alone ($10)</td><td></td><td>-</td><td>30 %</td></tr><tr><td>Total annual cost</td><td>$314,008<i>[$287,406 - $502,522]</i></td><td>$250,332</td><td>$219,408</td></tr><tr><td>Percent decrease from current costs</td><td>-</td><td>20 %</td><td>30 %</td></tr></table>
<table><tr><td></td><td>Current</td></tr><tr><td></td><td></td></tr><tr><td colspan="2">Procedure type distribution for first trimester, legal, induced abortion</td></tr><tr><td>MVA ($17)</td><td></td></tr><tr><td>Misoprostol-alone ($10)</td><td></td></tr><tr><td>Total annual cost</td><td>$314,008[$287,406 - $502,522]</td></tr><tr><td>Percent decrease from current costs</td><td>-</td></tr></table>
<table><tr><td colspan="2">Projected</td></tr><tr><td>Only MVA3</td><td>MVA/Misoprostol4</td></tr><tr><td colspan="2">Procedure type distribution for first trimester, legal, induced abortion</td></tr><tr><td>100 %</td><td>70 %</td></tr><tr><td>-</td><td>30 %</td></tr><tr><td>$250,332</td><td>$219,408</td></tr><tr><td>20 %</td><td>30 %</td></tr></table>
b6e71e1fec0a51029b7a44ca7d1ad214d381901798e31cc35be8259166fa77e8.png
complex
<table><tr><td>Clinical parameter</td><td>SLE patients</td><td>Healthy Controls</td><td><i>P</i> value</td></tr><tr><td>Patients (number)</td><td>52</td><td>52</td><td>&#8211;</td></tr><tr><td>Age (years)</td><td>31 (12&#8211;52)</td><td>32 (20&#8211;56)</td><td>0.438</td></tr><tr><td>Female:Male ratio</td><td>46:6</td><td>45:7</td><td>0.767</td></tr><tr><td colspan="4">Laboratory data</td></tr><tr><td> TG (mmol/L)</td><td>1.62 (0.50&#8211;8.93)</td><td>0.80 (0.35&#8211;2.52)</td><td>&lt;0.001</td></tr><tr><td> TC (mmol/L)</td><td>4.18 (1.92&#8211;9.28)</td><td>4.28 (3.25&#8211;5.52)</td><td>0.207</td></tr><tr><td> HDL (mmol/L)</td><td>1.06 (0.35&#8211;2.01)</td><td>1.44 (1.05&#8211;2.15)</td><td>&lt;0.001</td></tr><tr><td> LDL (mmol/L)</td><td>2.50 (0.89&#8211;7.06)</td><td>2.53 (1.44&#8211;3.78)</td><td>0.062</td></tr><tr><td> APOA1 (g/L)</td><td>1.14 (0.57&#8211;2.01)</td><td>1.45 (1.08&#8211;1.89)</td><td>&lt;0.001</td></tr><tr><td> APOB (g/L)</td><td>0.93 (0.38&#8211;2.06)</td><td>0.89 (0.57&#8211;1.25)</td><td>0.002</td></tr><tr><td> APOM (mg/L)</td><td>2.92 (1.54-17.75)</td><td>14.80 (3.53&#8211;56.07)</td><td>&lt;0.001</td></tr><tr><td> Lpa (mg/L)</td><td>154.15 (9.70&#8211;1517.40)</td><td>78.80 (3.40&#8211;1043.50)</td><td>0.041</td></tr><tr><td> hs-CRP (mg/L)</td><td>2.26 (0.12&#8211;125.44)</td><td>0.37 (0.04&#8211;5.68)</td><td>0.008</td></tr><tr><td> 25-OHD3 (ng/ml)</td><td>9.72 (3.00-19.26)</td><td>16.16 (6.98-34.22)</td><td>&lt;0.001</td></tr><tr><td> Anti-dsDNA antibodies (%)</td><td>19 (36.5%)</td><td>&#8211;</td><td>&#8211;</td></tr><tr><td> Anti-SM antibodies (%)</td><td>21 (40.4%)</td><td>&#8211;</td><td>&#8211;</td></tr><tr><td> SLEDAI</td><td>15 (5-29)</td><td>&#8211;</td><td>&#8211;</td></tr></table>
<table><tr><td>Clinical parameter</td><td>SLE patients</td><td>Healthy Controls</td><td>P value</td></tr><tr><td>Patients (number)</td><td>52</td><td>52</td><td>–</td></tr><tr><td>Age (years)</td><td>31 (12–52)</td><td>32 (20–56)</td><td>0.438</td></tr><tr><td>Female:Male ratio</td><td>46:6</td><td>45:7</td><td>0.767</td></tr><tr><td colspan="4">Laboratory data</td></tr><tr><td>TG (mmol/L)</td><td>1.62 (0.50–8.93)</td><td>0.80 (0.35–2.52)</td><td><0.001</td></tr><tr><td>TC (mmol/L)</td><td>4.18 (1.92–9.28)</td><td>4.28 (3.25–5.52)</td><td>0.207</td></tr></table>
<table><tr><td>HDL (mmol/L)</td><td>1.06 (0.35–2.01)</td><td>1.44 (1.05–2.15)</td><td><0.001</td></tr><tr><td>LDL (mmol/L)</td><td>2.50 (0.89–7.06)</td><td>2.53 (1.44–3.78)</td><td>0.062</td></tr><tr><td>APOA1 (g/L)</td><td>1.14 (0.57–2.01)</td><td>1.45 (1.08–1.89)</td><td><0.001</td></tr><tr><td>APOB (g/L)</td><td>0.93 (0.38–2.06)</td><td>0.89 (0.57–1.25)</td><td>0.002</td></tr><tr><td>APOM (mg/L)</td><td>2.92 (1.54-17.75)</td><td>14.80 (3.53–56.07)</td><td><0.001</td></tr><tr><td>Lpa (mg/L)</td><td>154.15 (9.70–1517.40)</td><td>78.80 (3.40–1043.50)</td><td>0.041</td></tr><tr><td>hs-CRP (mg/L)</td><td>2.26 (0.12–125.44)</td><td>0.37 (0.04–5.68)</td><td>0.008</td></tr><tr><td>25-OHD3 (ng/ml)</td><td>9.72 (3.00-19.26)</td><td>16.16 (6.98-34.22)</td><td><0.001</td></tr><tr><td>Anti-dsDNA antibodies (%)</td><td>19 (36.5%)</td><td>–</td><td>–</td></tr><tr><td>Anti-SM antibodies (%)</td><td>21 (40.4%)</td><td>–</td><td>–</td></tr><tr><td>SLEDAI</td><td>15 (5-29)</td><td>–</td><td>–</td></tr></table>
a07c7da399aafbae824a0562b782635416e68af64f9415f68c22c54e9ffc6bba.png
simple
<table><tr><td><i>Model</i></td><td>Test set</td><td>SN<i>(%)</i></td><td>PE<i>(%)</i></td><td>ACC<i>(%)</i></td><td>MCC<i>(%)</i></td><td>AUC<i>(%)</i></td></tr><tr><td>Ourmethod</td><td>1</td><td>91.66</td><td>92.40</td><td>92.00</td><td>85.28</td><td>97.15</td></tr><tr><td></td><td>2</td><td>90.49</td><td>92.01</td><td>91.11</td><td>83.79</td><td>96.91</td></tr><tr><td></td><td>3</td><td>91.13</td><td>91.05</td><td>91.19</td><td>83.94</td><td>96.97</td></tr><tr><td></td><td>4</td><td>90.41</td><td>91.48</td><td>91.01</td><td>83.64</td><td>97.07</td></tr><tr><td></td><td>5</td><td>89.64</td><td>92.76</td><td>91.47</td><td>84.38</td><td>97.23</td></tr><tr><td></td><td>Average</td><td>90.67 &#177; 0.69</td><td>91.94 &#177; 0.62</td><td>91.36 &#177; 0.36</td><td>84.21 &#177; 0.59</td><td>97.07 &#177; 0.12</td></tr><tr><td>Guos' work</td><td>ACC</td><td>89.93 &#177; 3.68</td><td>88.87 &#177; 6.16</td><td>89.33 &#177; 2.67</td><td>N/A</td><td>N/A</td></tr><tr><td></td><td>AC</td><td>87.30 &#177; 4.68</td><td>87.82 &#177; 4.33</td><td>87.36 &#177; 1.38</td><td>N/A</td><td>N/A</td></tr><tr><td>Zhous'work</td><td>SVM+LD</td><td>87.37 &#177; 0.22</td><td>89.50 &#177; 0.60</td><td>88.56 &#177; 0.33</td><td>77.15 &#177; 0.68</td><td>95.07 &#177; 0.39</td></tr><tr><td>Yangs'work</td><td>Cod1</td><td>75.81 &#177; 1.20</td><td>74.75 &#177; 1.23</td><td>75.08 &#177; 1.13</td><td>N/A</td><td>N/A</td></tr><tr><td></td><td>Cod2</td><td>76.77 &#177; 0.69</td><td>82.17 &#177; 1.35</td><td>80.04 &#177; 1.06</td><td>N/A</td><td>N/A</td></tr><tr><td></td><td>Cod3</td><td>78.14 &#177; 0.90</td><td>81.86 &#177; 0.99</td><td>80.41 &#177; 0.47</td><td>N/A</td><td>N/A</td></tr><tr><td></td><td>Cod4</td><td>81.03 &#177; 1.74</td><td>90.24 &#177; 1.34</td><td>86.15 &#177; 1.17</td><td>N/A</td><td>N/A</td></tr></table>
<table><tr><td>Model</td><td>Test set</td><td>SN(%)</td><td>PE(%)</td><td>ACC(%)</td><td>MCC(%)</td><td>AUC(%)</td></tr><tr><td>Ourmethod</td><td>1</td><td>91.66</td><td>92.40</td><td>92.00</td><td>85.28</td><td>97.15</td></tr><tr><td></td><td>2</td><td>90.49</td><td>92.01</td><td>91.11</td><td>83.79</td><td>96.91</td></tr><tr><td></td><td>3</td><td>91.13</td><td>91.05</td><td>91.19</td><td>83.94</td><td>96.97</td></tr><tr><td></td><td>4</td><td>90.41</td><td>91.48</td><td>91.01</td><td>83.64</td><td>97.07</td></tr><tr><td></td><td>5</td><td>89.64</td><td>92.76</td><td>91.47</td><td>84.38</td><td>97.23</td></tr><tr><td></td><td>Average</td><td>90.67 ± 0.69</td><td>91.94 ± 0.62</td><td>91.36 ± 0.36</td><td>84.21 ± 0.59</td><td>97.07 ± 0.12</td></tr><tr><td>Guos' work</td><td>ACC</td><td>89.93 ± 3.68</td><td>88.87 ± 6.16</td><td>89.33 ± 2.67</td><td>N/A</td><td>N/A</td></tr><tr><td></td><td>AC</td><td>87.30 ± 4.68</td><td>87.82 ± 4.33</td><td>87.36 ± 1.38</td><td>N/A</td><td>N/A</td></tr><tr><td>Zhous'work</td><td>SVM+LD</td><td>87.37 ± 0.22</td><td>89.50 ± 0.60</td><td>88.56 ± 0.33</td><td>77.15 ± 0.68</td><td>95.07 ± 0.39</td></tr><tr><td>Yangs'work</td><td>Cod1</td><td>75.81 ± 1.20</td><td>74.75 ± 1.23</td><td>75.08 ± 1.13</td><td>N/A</td><td>N/A</td></tr><tr><td></td><td>Cod2</td><td>76.77 ± 0.69</td><td>82.17 ± 1.35</td><td>80.04 ± 1.06</td><td>N/A</td><td>N/A</td></tr><tr><td></td><td>Cod3</td><td>78.14 </td><td></td><td>80.41</td><td>N/</td><td>N</td></tr></table>
<table><tr><td>Test set</td><td>SN(%)</td><td>PE(%)</td><td>ACC(%)</td><td>MCC(%)</td><td>AUC(%)</td></tr><tr><td></td><td>± 0.90</td><td>81.86 ± 0.99</td><td> ± 0.47</td><td>A</td><td>/A</td></tr><tr><td>Cod4</td><td>81.03 ± 1.74</td><td>90.24 ± 1.34</td><td>86.15 ± 1.17</td><td>N/A</td><td>N/A</td></tr></table>
8221051755f64d9ba35697241eca13022fcc1bcf7e9efeb14bcaf5c7c327496d.png
simple
<table><tr><td>Compound</td><td>Inhibitor concentration (mg/L)</td></tr><tr><td>Furfural</td><td>19.65 &#177; 0.81</td></tr><tr><td>Hydroxymethylfurfural (HMF)</td><td>3.89 &#177; 0.25</td></tr><tr><td>Glucuronic acid</td><td>ND</td></tr><tr><td><i>p</i>-coumaric acid</td><td>ND</td></tr><tr><td>Syringic acid</td><td>ND</td></tr><tr><td>Ferulic acid</td><td>ND</td></tr></table>
<table><tr><td>Compound</td><td>Inhibitor concentration (mg/L)</td></tr><tr><td>Furfural</td><td>19.65 ± 0.81</td></tr><tr><td>Hydroxymethylfurfural (HMF)</td><td>3.89 ± 0.25</td></tr></table>
<table><tr><td>Compound</td><td>Inhibitor concentration (mg/L)</td></tr><tr><td>Glucuronic acid</td><td>ND</td></tr><tr><td>p-coumaric acid</td><td>ND</td></tr><tr><td>Syringic acid</td><td>ND</td></tr><tr><td>Ferulic acid</td><td>ND</td></tr></table>
2335d20dde27a54e190453202bf4c6adc3a78b1a16bee9add7c317b0f8b712e3.png
complex
<table><tr><td colspan="2">Targeted neurotransmitter</td><td>Agents under investigation</td><td>Status</td><td>Ref.</td></tr><tr><td colspan="2">Acetylcholine</td><td>LatrepirdineHuperzine A</td><td>(III)</td><td>76</td></tr><tr><td rowspan="2" colspan="2">GABA</td><td>SGS742</td><td>(II)*</td><td></td></tr><tr><td>ADS&#8208;8704 (NMDA antagonist)</td><td>(III)</td><td></td></tr><tr><td rowspan="3">Serotonin</td><td>5HT1A</td><td>Lecozotan</td><td>(II)</td><td></td></tr><tr><td>5&#8208;HT4</td><td>PRX&#8208;03140TD&#8208;8954</td><td>&#8211;</td><td></td></tr><tr><td>5&#8208;HT6</td><td>SB&#8208;742457</td><td>(II)</td><td></td></tr><tr><td colspan="2">Histamine</td><td>PF03654746AB288</td><td>(I)(II)</td><td></td></tr><tr><td colspan="2">Adenosine</td><td>SCH58261</td><td>&#8211;</td><td></td></tr></table>
<table><tr><td colspan="2">Targeted neurotransmitter</td><td>Agents under investigation</td><td>Status</td><td>Ref.</td></tr><tr><td colspan="2">Acetylcholine</td><td>LatrepirdineHuperzine A</td><td>(III)</td><td>76</td></tr><tr><td rowspan="2" colspan="2">GABA</td><td>SGS742</td><td>(II)*</td><td></td></tr><tr><td>ADS‐8704 (NMDA antagonist)</td><td>(III)</td><td></td></tr><tr><td rowspan="3">Serotonin</td><td>5HT1A</td><td>Lecozotan</td><td>(II)</td><td></td></tr><tr><td>5‐HT4</td><td>PRX‐03140TD‐8954</td><td>–</td><td></td></tr><tr><td>5‐HT6</td><td>SB‐742457</td><td>(II)</td><td></td></tr><tr><td colspan="2">Histamine</td><td>PF03654746AB288</td><td>(I)(II)</td><td></td></tr></table>
<table><tr><td colspan="2">Targeted neurotransmitter</td><td>Agents under investigation</td><td>Status</td></tr><tr><td colspan="2">Adenosine</td><td>SCH58261</td><td>–</td></tr></table>
d07a72584a090448d5505e46d0b7e5be67cde7cade21b0b1282b7c3ca077e195.png
complex
<table><tr><td colspan="2"><i>Factors</i></td><td><i>Outcome (n = 10)</i></td></tr><tr><td rowspan="2"><i>Boiling/treatment of drinking water:</i></td><td>Yes</td><td>0</td></tr><tr><td>No</td><td>10 (100%)</td></tr><tr><td rowspan="2"><i>Regular hand washing after toilet use</i>:</td><td>Yes</td><td>3 (30%)</td></tr><tr><td>No</td><td>7 (70%)</td></tr><tr><td rowspan="3"><i>Regular hand washing after handling pork with:</i></td><td>Soap</td><td>9 (90%)</td></tr><tr><td>Sanitizer</td><td>0</td></tr><tr><td>Water only</td><td>1 (10%)</td></tr><tr><td rowspan="2"><i>Wearing of hand gloves and aprons at work:</i></td><td>Yes</td><td>0</td></tr><tr><td>No</td><td>10 (100%)</td></tr><tr><td rowspan="2"><i>Consumption of pork:</i></td><td>Yes</td><td>10 (100%)</td></tr><tr><td>No</td><td>0</td></tr><tr><td rowspan="2"><i>Roasting and eating pork while handling raw pork:</i></td><td>Yes</td><td>4 (40%)</td></tr><tr><td>No</td><td>6 (60%)</td></tr><tr><td rowspan="3"><i>Method of pork processing for consumption:</i></td><td>Cooked</td><td>4 (40%)</td></tr><tr><td>Cooked and fried</td><td>2 (20%)</td></tr><tr><td>Roasted</td><td>4 (40%)</td></tr><tr><td rowspan="2"><i>Knowledge on public health significance of Taenia solium:</i></td><td>Yes</td><td>0</td></tr><tr><td>No</td><td>10 (100%)</td></tr></table>
<table><tr><td colspan="2">Factors</td><td>Outcome (n = 10)</td></tr><tr><td rowspan="2">Boiling/treatment of drinking water:</td><td>Yes</td><td>0</td></tr><tr><td>No</td><td>10 (100%)</td></tr><tr><td rowspan="2">Regular hand washing after toilet use:</td><td>Yes</td><td>3 (30%)</td></tr><tr><td>No</td><td>7 (70%)</td></tr><tr><td rowspan="3">Regular hand washing after handling pork with:</td><td>Soap</td><td>9 (90%)</td></tr><tr><td>Sanitizer</td><td>0</td></tr><tr><td>Water only</td><td>1 (10%)</td></tr><tr><td rowspan="2">Wearing of hand gloves and aprons at work:</td><td>Yes</td><td>0</td></tr><tr><td>No</td><td>10 (100%)</td></tr></table>
<table><tr><td rowspan="2">Consumption of pork:</td><td>Yes</td><td>10 (100%)</td></tr><tr><td>No</td><td>0</td></tr><tr><td rowspan="2">Roasting and eating pork while handling raw pork:</td><td>Yes</td><td>4 (40%)</td></tr><tr><td>No</td><td>6 (60%)</td></tr><tr><td rowspan="3">Method of pork processing for consumption:</td><td>Cooked</td><td>4 (40%)</td></tr><tr><td>Cooked and fried</td><td>2 (20%)</td></tr><tr><td>Roasted</td><td>4 (40%)</td></tr><tr><td rowspan="2">Knowledge on public health significance of Taenia solium:</td><td>Yes</td><td>0</td></tr><tr><td>No</td><td>10 (100%)</td></tr></table>
de6b84b3585655ef96da0dbc4375404cdc5e946036fa5ae169201b3b371650b6.png
simple
<table><tr><td>Abiotic stress</td><td></td><td>Reference</td></tr><tr><td>Drought</td><td>CZP 9802; 863B, PRLT 2/89-33ICMP 83720, ICMV 9413, and ICMV 94472</td><td>Yadav, 2004; Dwivedi et al., 2010</td></tr><tr><td>Heat</td><td>H77/833-2, H77/29-2, CVJ 2-5-3-1-3, 77/371XBSECT CP1, 96AC-93, 1305, 77/371, Togo II, 99HS-18, G73107, 77/371</td><td>Yadav et al., 2014</td></tr><tr><td>Salinity</td><td>ICMB 02111, ICMB 94555, ICMB 95333, ICMB 00888, ICMB 01222, ICMP 451, IP 3732, IP 3757, IP8210, and PRLT 2/89-33, 10876 and 10878 (Sudan), 18406 and 18570 (Namibia), and ICMV93753 and ICMV 94474 (India); 863-B, CZI 98-11, CZI 9621, HTP 94/54</td><td>Ali et al., 2004; Dwivedi et al., 2010</td></tr><tr><td>Biotic stress</td><td>IP #16438 and 16762; P 310-17 and P 1449-3; IP18292; IP18293;700651; ICML #12, 13, 14, 15, 16, and 22; ICMP #312, 423, and 85410; 7042S; 841A; IP #9, 55, 104, 253, 262, 336, 346, 498, 545, and 558; landrace such as Ardi-Beniya Ka Bas, Dhodsar local and Desi Bajri-Chomu</td><td>Singh et al., 1997; Khairwal and Yadav, 2005; Thakur et al., 2006; Sharma et al., 2007</td></tr><tr><td>Downy mildew (<i>Sclerospora graminicola</i>)</td><td>ICMPE #13-6-30, 134-6-9, 134-6-34, 13-6-27, 37, and 71;ICML #1, 2, 3, 4, 5, 6, 7, 8, 9, 10; ICMA #91333, 91444, and 91555; ICMA 92666 and ICMB 92666 (resistant to ergot, smut, and downy mildew)</td><td>Thakur et al., 1982; Willingale et al., 1986; Thakur and King, 1988a,b; Thakur et al., 1992; Rai et al., 1998b; Khairwal and Yadav, 2005</td></tr><tr><td>Ergot (<i>Claviceps fusiformis</i>)</td><td>ExB 46-1-2-S-2, ExB 112-1-S-1-1, ICMV 8282, ICMV8283; ICMA 88006A and ICMA 88006B (resistant to smut and downy mildew);ICMA#91333, 91444 and 91555; 44 accessions selected from the screening of 1747 germplasm; ICML #5&#8211;10; ICMPS #100-5-1, 700-1-5-4, 900-1-4-1, 900-3-1, 900-9-3, 1300-2-1-2, 1400-1-6-2, 1600-2-4, 1500-7-3-2, 1800-3-1-2, and 2000-5-2; SSC FS 252-S-4, ICI 7517-S-1, ExB 132-2-S-5-2-DM-1, and P-489-S-3; SSC 46-2-2-1, SC 77-7-2-3-1, SSC 18-7-3-1</td><td>Thakur et al., 1983; Thakur and King, 1988c; Yadav and Duhan, 1996; Rai et al., 1998a; Khairwal and Yadav, 2005</td></tr><tr><td>Smut (<i>Moesziomyces penicillariae</i>)</td><td>ICML #5, 6, 7, 8, 9, and 10; ICML #17, 18, 19, 20 and 21; Tif leaf 3; Tift 3 (PI 547035) and Tift 4 (PI 547036); Tift 65 (resistant to rust and leaf spot)</td><td>Bourland, 1987; Thakur and King, 1988a; Wilson and Burton, 1991; Burton and Wilson, 1995; Hanna et al., 1997</td></tr><tr><td>Rust (<i>Puccinia</i> sp.)</td><td>IP #16438 and 16762; P 310-17 and P 1449-3; IP18292; IP18293;700651; ICML #12, 13, 14, 15, 16, and 22; ICMP #312, 423, and 85410; 7042S; 841A; IP #9, 55, 104, 253, 262, 336, 346, 498, 545, and 558; landrace such as Ardi-Beniya Ka Bas, Dhodsar local and Desi Bajri-Chomu</td><td>Singh et al., 1997; Khairwal and Yadav, 2005; Thakur et al., 2006; Sharma et al., 2007</td></tr></table>
<table><tr><td>Abiotic stress</td><td></td><td>Reference</td></tr><tr><td>Drought</td><td>CZP 9802; 863B, PRLT 2/89-33ICMP 83720, ICMV 9413, and ICMV 94472</td><td>Yadav, 2004; Dwivedi et al., 2010</td></tr><tr><td>Heat</td><td>H77/833-2, H77/29-2, CVJ 2-5-3-1-3, 77/371XBSECT CP1, 96AC-93, 1305, 77/371, Togo II, 99HS-18, G73107, 77/371</td><td>Yadav et al., 2014</td></tr><tr><td>Salinity</td><td>ICMB 02111, ICMB 94555, ICMB 95333, ICMB 00888, ICMB 01222, ICMP 451, IP 3732, IP 3757, IP8210, and PRLT 2/89-33, 10876 and 10878 (Sudan), 18406 and 18570 (Namibia), and ICMV93753 and ICMV 94474 (India); 863-B, CZI 98-11, CZI 9621, HTP 94/54</td><td>Ali et al., 2004; Dwivedi et al., 2010</td></tr><tr><td>Biotic stress</td><td>IP #16438 and 16762; P 310-17 and P 1449-3; IP18292; IP18293;700651; ICML #12, 13, 14, 15, 16, and 22; ICMP #312, 423, and 85410; 7042S; 841A; IP #9, 55, 104, 253, 262, 336, 346, 498, 545, and 558; landrace such as Ardi-Beniya Ka Bas, Dhodsar local and Desi Bajri-Chomu</td><td>Singh et al., 1997; Khairwal and Yadav, 2005; Thakur et al., 2006; Sharma et al., 2007</td></tr></table>
<table><tr><td>Downy mildew (Sclerospora graminicola)</td><td>ICMPE #13-6-30, 134-6-9, 134-6-34, 13-6-27, 37, and 71;ICML #1, 2, 3, 4, 5, 6, 7, 8, 9, 10; ICMA #91333, 91444, and 91555; ICMA 92666 and ICMB 92666 (resistant to ergot, smut, and downy mildew)</td><td>Thakur et al., 1982; Willingale et al., 1986; Thakur and King, 1988a,b; Thakur et al., 1992; Rai et al., 1998b; Khairwal and Yadav, 2005</td></tr><tr><td>Ergot (Claviceps fusiformis)</td><td>ExB 46-1-2-S-2, ExB 112-1-S-1-1, ICMV 8282, ICMV8283; ICMA 88006A and ICMA 88006B (resistant to smut and downy mildew);ICMA#91333, 91444 and 91555; 44 accessions selected from the screening of 1747 germplasm; ICML #5–10; ICMPS #100-5-1, 700-1-5-4, 900-1-4-1, 900-3-1, 900-9-3, 1300-2-1-2, 1400-1-6-2, 1600-2-4, 1500-7-3-2, 1800-3-1-2, and 2000-5-2; SSC FS 252-S-4, ICI 7517-S-1, ExB 132-2-S-5-2-DM-1, and P-489-S-3; SSC 46-2-2-1, SC 77-7-2-3-1, SSC 18-7-3-1</td><td>Thakur et al., 1983; Thakur and King, 1988c; Yadav and Duhan, 1996; Rai et al., 1998a; Khairwal and Yadav, 2005</td></tr><tr><td>Smut (Moesziomyces penicillariae)</td><td>ICML #5, 6, 7, 8, 9, and 10; ICML #17, 18, 19, 20 and 21; Tif leaf 3; Tift 3 (PI 547035) and Tift 4 (PI 547036); Tift 65 (resistant to rust and leaf spot)</td><td>Bourland, 1987; Thakur and King, 1988a; Wilson and Burton, 1991; Burton and Wilson, 1995; Hanna et al., 1997</td></tr><tr><td>Rust (Puccinia sp.)</td><td>IP #16438 and 16762; P 310-17 and P 1449-3; IP18292; IP18293;700651; ICML #12, 13, 14, 15, 16, and 22; ICMP #312, 423, and 85410; 7042S; 841A; IP #9, 55, 104, 253, 262, 336, 346, 498, 545, and 558; landrace such as Ardi-Beniya Ka Bas, Dhodsar local and Desi Bajri-Chomu</td><td>Singh et al., 1997; Khairwal and Yadav, 2005; Thakur et al., 2006; Sharma et al., 2007</td></tr></table>
64cc32e7112502f5d59e99c0bcd202b3bcc4b41f5df4d0ffbb541fc8e1e9a919.png
complex
<table><tr><td rowspan="2" colspan="2">Variables</td><td colspan="2">Attempted suicide</td><td colspan="2">Completed suicide</td><td rowspan="2"><i>p</i>-value</td></tr><tr><td>No. (%)</td><td>Annual incidence rate</td><td>No. (%)</td><td>Annual incidence rate</td></tr><tr><td rowspan="2">Gender</td><td>Male</td><td>2939(96.9)</td><td>74.98</td><td>94(3.1)</td><td>2.40</td><td rowspan="2">0.004</td></tr><tr><td>Female</td><td>3649(98)</td><td>94.51</td><td>75(2)</td><td>1.94</td></tr><tr><td rowspan="7">Age</td><td>10&#8211;14years</td><td>143(98.6)</td><td>20.21</td><td>2(1.4)</td><td>0.28</td><td rowspan="7">0.0001</td></tr><tr><td>15&#8211;24year</td><td>4001(97.7)</td><td>172.42</td><td>96(2.3)</td><td>4.14</td></tr><tr><td>25&#8211;34years</td><td>1788(98)</td><td>82.87</td><td>36(2)</td><td>1.67</td></tr><tr><td>35&#8211;44years</td><td>411(96)</td><td>29</td><td>17(4)</td><td>1.2</td></tr><tr><td>45&#8211;54years</td><td>152(96.2)</td><td>17.88</td><td>6(3.8)</td><td>0.71</td></tr><tr><td>55&#8211;64years</td><td>51(92.7)</td><td>9</td><td>4(7.3)</td><td>0.71</td></tr><tr><td>&#8805;65 years</td><td>37(82.2)</td><td>7.83</td><td>8(17.8)</td><td>1.69</td></tr><tr><td rowspan="3">Marital status</td><td>Single</td><td>4008(97.5)</td><td>137.51</td><td>101(2.5)</td><td>3.47</td><td rowspan="3">0.001</td></tr><tr><td>Married</td><td>2532(97.5)</td><td>56.15</td><td>64(2.5)</td><td>1.42</td></tr><tr><td>Divorced and Widow</td><td>24(85.7)</td><td>6.73</td><td>4(14.3)</td><td>1.12</td></tr><tr><td rowspan="5">level of education</td><td>Illiterate</td><td>435(94.8)</td><td>29.46</td><td>24(5.2)</td><td>1.63</td><td rowspan="5">0.0001</td></tr><tr><td>Elementary</td><td>551(96.2)</td><td>49.33</td><td>22(3.8)</td><td>1.97</td></tr><tr><td>Secondary</td><td>1240(96.6)</td><td>140.47</td><td>43(3.4)</td><td>4.87</td></tr><tr><td>High school and Diploma</td><td>3278(98.3)</td><td>137.46</td><td>56(1.7)</td><td>2.35</td></tr><tr><td>University educated</td><td>759(98.4)</td><td>42.88</td><td>12(1.6)</td><td>0.68</td></tr><tr><td rowspan="7">Occupation status</td><td>Housewife</td><td>1581(98.1)</td><td>71.17</td><td>30(1.9)</td><td>1.35</td><td rowspan="7">0.0001</td></tr><tr><td>Unemployed</td><td>2291(97.9)</td><td>295.54</td><td>48(2.1)</td><td>6.19</td></tr><tr><td>Self-employed</td><td>526(97.2)</td><td>117.87</td><td>15(2.8)</td><td>3.36</td></tr><tr><td>Office worker</td><td>173(97.2)</td><td>23.4</td><td>5(2.8)</td><td>0.68</td></tr><tr><td>Farmer</td><td>109(86.5)</td><td>13.03</td><td>17(13.5)</td><td>2.03</td></tr><tr><td>Student</td><td>1308(97.6)</td><td>70.66</td><td>32(2.4)</td><td>1.73</td></tr><tr><td>Worker</td><td>128(96.2)</td><td>45.54</td><td>5(3.8)</td><td>1.78</td></tr><tr><td rowspan="2">place of life</td><td>Urban</td><td>3544(98.3)</td><td>71.05</td><td>61(1.7)</td><td>1.22</td><td rowspan="2">0.005</td></tr><tr><td>Rural</td><td>2001(97.2)</td><td>72.03</td><td>57(2.8)</td><td>2.05</td></tr><tr><td rowspan="8">City of Residence</td><td>Abdanan</td><td>531(98.3)</td><td>81.62</td><td>9(1.7)</td><td>1.38</td><td rowspan="8">0.087</td></tr><tr><td>Ilam</td><td>2615(97.9)</td><td>87.38</td><td>57(2.1)</td><td>1.9</td></tr><tr><td>Ayvan</td><td>942(98)</td><td>134.46</td><td>19(2)</td><td>2.71</td></tr><tr><td>Dareh-shahr</td><td>1289(96.6)</td><td>154.56</td><td>45(3.4)</td><td>5.4</td></tr><tr><td>Dehloran</td><td>349(98.9)</td><td>38.31</td><td>4(1.1)</td><td>0.44</td></tr><tr><td>Shirvan-Chardavol</td><td>585(97.2)</td><td>57.84</td><td>17(2.8)</td><td>1.68</td></tr><tr><td>Malekshahi</td><td>89(96.7)</td><td>28.91</td><td>3(3.3)</td><td>0.97</td></tr><tr><td>Mehran</td><td>130(96.3)</td><td>34.55</td><td>5(3.7)</td><td>1.33</td></tr></table>
<table><tr><td rowspan="2" colspan="2">Variables</td><td colspan="2">Attempted suicide</td><td colspan="2">Completed suicide</td><td rowspan="2">p-value</td></tr><tr><td>No. (%)</td><td>Annual incidence rate</td><td>No. (%)</td><td>Annual incidence rate</td></tr><tr><td rowspan="2">Gender</td><td>Male</td><td>2939(96.9)</td><td>74.98</td><td>94(3.1)</td><td>2.40</td><td rowspan="2">0.004</td></tr><tr><td>Female</td><td>3649(98)</td><td>94.51</td><td>75(2)</td><td>1.94</td></tr><tr><td rowspan="7">Age</td><td>10–14years</td><td>143(98.6)</td><td>20.21</td><td>2(1.4)</td><td>0.28</td><td rowspan="7">0.0001</td></tr><tr><td>15–24year</td><td>4001(97.7)</td><td>172.42</td><td>96(2.3)</td><td>4.14</td></tr><tr><td>25–34years</td><td>1788(98)</td><td>82.87</td><td>36(2)</td><td>1.67</td></tr><tr><td>35–44years</td><td>411(96)</td><td>29</td><td>17(4)</td><td>1.2</td></tr><tr><td>45–54years</td><td>152(96.2)</td><td>17.88</td><td>6(3.8)</td><td>0.71</td></tr><tr><td>55–64years</td><td>51(92.7)</td><td>9</td><td>4(7.3)</td><td>0.71</td></tr><tr><td>≥65 years</td><td>37(82.2)</td><td>7.83</td><td>8(17.8)</td><td>1.69</td></tr><tr><td rowspan="3">Marital status</td><td>Single</td><td>4008(97.5)</td><td>137.51</td><td>101(2.5)</td><td>3.47</td><td rowspan="3">0.001</td></tr><tr><td>Married</td><td>2532(97.5)</td><td>56.15</td><td>64(2.5)</td><td>1.42</td></tr><tr><td>Divorced and Widow</td><td>24(85.7)</td><td>6.73</td><td>4(14.3)</td><td>1.12</td></tr><tr><td rowspan="5">level of education</td><td>Illiterate</td><td>435(94.8)</td><td>29.46</td><td>24(5.2)</td><td>1.63</td><td rowspan="5">0.0001</td></tr><tr><td>Elementary</td><td>551(96.2)</td><td>49.33</td><td>22(3.8)</td><td>1.97</td></tr><tr><td>Secondary</td><td>1240(96.6)</td><td>140.47</td><td>43(3.4)</td><td>4.87</td></tr><tr><td>High school and Diploma</td><td>3278(98.3)</td><td>137.46</td><td>56(1.7)</td><td>2.35</td></tr><tr><td>University educated</td><td>759(98.4)</td><td>42.88</td><td>12(1.6)</td><td>0.68</td></tr><tr><td rowspan="7">Occupation status</td><td>Housewife</td><td>1581(98.1)</td><td>71.17</td><td>30(1.9)</td><td>1.35</td><td rowspan="7">0.0001</td></tr><tr><td>Unemployed</td><td>2291(97.9)</td><td>295.54</td><td>48(2.1)</td><td>6.19</td></tr><tr><td>Self-employed</td><td>526(97.2)</td><td>117.87</td><td>15(2.8)</td><td>3.36</td></tr><tr><td>Office worker</td><td>173(97.2)</td><td>23.4</td><td>5(2.8)</td><td>0.68</td></tr><tr><td>Farmer</td><td>109(86.5)</td><td>13.03</td><td>17(13.5)</td><td>2.03</td></tr><tr><td>Student</td><td>1308(97.6)</td><td>70.66</td><td>32(2.4)</td><td>1.73</td></tr><tr><td>Worker</td><td>128(96.2)</td><td>45.54</td><td>5(3.8)</td><td>1.78</td></tr><tr><td rowspan="2">place of life</td><td>Urban</td><td>3544(98.3)</td><td>71.05</td><td>61(1.7)</td><td>1.22</td><td rowspan="2">0.005</td></tr><tr><td>Rural</td><td>2001(97.2)</td><td>72.03</td><td>57(2.8)</td><td>2.05</td></tr><tr><td>City of Residence</td><td>Abdanan</td><td>531(98.3)</td><td>81.62</td><td>9(1.7)</td><td>1.38</td><td>0.087</td></tr></table>
<table><tr><td rowspan="7">City of Residence</td><td>Ilam</td><td>2615(97.9)</td><td>87.38</td><td>57(2.1)</td><td>1.9</td><td rowspan="7">0.087</td></tr><tr><td>Ayvan</td><td>942(98)</td><td>134.46</td><td>19(2)</td><td>2.71</td></tr><tr><td>Dareh-shahr</td><td>1289(96.6)</td><td>154.56</td><td>45(3.4)</td><td>5.4</td></tr><tr><td>Dehloran</td><td>349(98.9)</td><td>38.31</td><td>4(1.1)</td><td>0.44</td></tr><tr><td>Shirvan-Chardavol</td><td>585(97.2)</td><td>57.84</td><td>17(2.8)</td><td>1.68</td></tr><tr><td>Malekshahi</td><td>89(96.7)</td><td>28.91</td><td>3(3.3)</td><td>0.97</td></tr><tr><td>Mehran</td><td>130(96.3)</td><td>34.55</td><td>5(3.7)</td><td>1.33</td></tr></table>
73ba9d726e55ded0c90da424fa4c9f2c6e905da161eac492c3ba2db62390c4eb.png
simple
<table><tr><td> </td><td> </td><td> </td><td>Unexposed</td><td>Exposed*</td><td>Surgery targeted by study</td></tr><tr><td>Time window</td><td>Tissue/structure group</td><td>Subject</td><td>No. (%)</td><td>No. (%)</td><td>OR (95% CI)</td></tr><tr><td>Time window 4</td><td>Lymph nodes</td><td><i>Case</i></td><td>165 (98.8)</td><td>2 (1.2)</td><td> </td></tr><tr><td> </td><td> </td><td>MC</td><td>831 (99.5)</td><td>4 (0.5)</td><td>2.50 (0.46&#8211;13.72)</td></tr><tr><td> </td><td> </td><td>UMC</td><td>2,216 (99.6)</td><td>8 (0.4)</td><td>3.13 (0.72&#8211;13.69)</td></tr><tr><td> </td><td>Blood vessels</td><td>Case</td><td>165 (98.8)</td><td>2 (1.2)</td><td> </td></tr><tr><td> </td><td> </td><td>MC</td><td>828 (99.2)</td><td>7 (0.8)</td><td>1.46 (0.33&#8211;6.48)</td></tr><tr><td> </td><td> </td><td>UMC</td><td>2,217 (99.7)</td><td>7 (0.3)</td><td>3.88 (0.82&#8211;18.34)</td></tr><tr><td> </td><td>Anterior ophthalmic</td><td><i>Case</i></td><td>166 (99.4)</td><td>1 (0.6)</td><td> </td></tr><tr><td> </td><td>structures</td><td>MC</td><td>833 (99.8)</td><td>2 (0.6)</td><td>2.50 (0.23&#8211;27.77)</td></tr><tr><td> </td><td> </td><td>UMC</td><td>2,217 (99.7)</td><td>7 (0.3)</td><td>1.77 (0.24&#8211;13.29)</td></tr><tr><td> </td><td>Skeletal muscle</td><td><i>Case</i></td><td>164 (98.2)</td><td>3 (1.8)</td><td> </td></tr><tr><td> </td><td> </td><td>MC</td><td>813 (97.4)</td><td>22 (2.6)</td><td>0.68 (0.20&#8211;2.29)</td></tr><tr><td> </td><td> </td><td>UMC</td><td>2,169 (97.5)</td><td>55 (2.5)</td><td>0.57 (0.17&#8211;1.89)</td></tr><tr><td> </td><td>Peritoneum</td><td><i>Case</i></td><td>162 (97.0)</td><td>5 (3.0)</td><td> </td></tr><tr><td> </td><td> </td><td>MC</td><td>826 (98.9)</td><td>9 (1.1)</td><td>2.78 (0.93&#8211;8.32)</td></tr><tr><td> </td><td> </td><td>UMC</td><td>2,194 (98.7)</td><td>30 (1.3)</td><td>2.13 (0.80&#8211;5.66)</td></tr><tr><td> </td><td>Other tissues</td><td><i>Case</i></td><td>161 (96.4)</td><td>6 (3.6)</td><td> </td></tr><tr><td> </td><td> </td><td>MC</td><td>826 (98.9)</td><td>9 (1.1)</td><td>3.51 (1.24&#8211;9.96)</td></tr><tr><td> </td><td> </td><td>UMC</td><td>2,190 (98.5)</td><td>34 (1.5)</td><td>2.02 (0.83&#8211;4.93)</td></tr><tr><td>Time window 5</td><td>Brain</td><td><i>Case</i></td><td>165 (98.8)</td><td>2 (1.2)</td><td> </td></tr><tr><td> </td><td> </td><td>MC</td><td>835 (100.0)</td><td>0 (0.0)</td><td> </td></tr><tr><td> </td><td> </td><td>UMC</td><td>2,223 (100.0)</td><td>1 (0.0)</td><td>36.35 (1.86&#8211;711.57)</td></tr><tr><td> </td><td>Dura mater</td><td><i>Case</i></td><td>165 (98.8)</td><td>2 (1.2)</td><td> </td></tr><tr><td> </td><td> </td><td>MC</td><td>835 (100.0)</td><td>0 (0.0)</td><td> </td></tr><tr><td> </td><td> </td><td>UMC</td><td>2,223 (100.0)</td><td>1 (0.0)</td><td>36.35 (1.86&#8211;711.57)</td></tr><tr><td> </td><td>Lymph nodes</td><td><i>Case</i></td><td>166 (99.4)</td><td>1 (0.6)</td><td> </td></tr><tr><td> </td><td> </td><td>MC</td><td>831 (99.5)</td><td>4 (0.5)</td><td>1.25 (0.14&#8211;11.26)</td></tr><tr><td> </td><td> </td><td>UMC</td><td>2,218 (99.7)</td><td>6 (0.3)</td><td>2.07 (0.28&#8211;15.05)</td></tr><tr><td> </td><td>Skeletal muscle</td><td><i>Case</i></td><td>161 (96.4)</td><td>6 (3.6)</td><td> </td></tr><tr><td> </td><td> </td><td>MC</td><td>825 (98.8)</td><td>10 (1.2)</td><td>3.13 (1.13&#8211;8.65)</td></tr><tr><td> </td><td> </td><td>UMC</td><td>2,196 (98.7)</td><td>28 (1.3)</td><td>2.76 (1.11&#8211;6.89)</td></tr><tr><td> </td><td>Peritoneum</td><td><i>Case</i></td><td>161 (96.4)</td><td>6 (3.6)</td><td> </td></tr><tr><td> </td><td> </td><td>MC</td><td>832 (99.6)</td><td>3 (0.4)</td><td>10.00 (2.49&#8211;40.15)</td></tr><tr><td> </td><td> </td><td>UMC</td><td>2,210 (99.4)</td><td>14 (0.6)</td><td>5.50 (2.07&#8211;14.66)</td></tr><tr><td> </td><td>Other tissues</td><td><i>Case</i></td><td>166 (99.4)</td><td>1 (0.6)</td><td> </td></tr><tr><td> </td><td> </td><td>MC</td><td>826 (98.9)</td><td>9 (1.1)</td><td>0.56 (0.07&#8211;4.41)</td></tr><tr><td> </td><td> </td><td>UMC</td><td>2,214 (99.6)</td><td>10 (0.4)</td><td>1.66 (0.19&#8211;14.86)</td></tr></table>
<table><tr><td></td><td></td><td></td><td>Unexposed</td><td>Exposed*</td><td>Surgery targeted by study</td></tr><tr><td>Time window</td><td>Tissue/structure group</td><td>Subject</td><td>No. (%)</td><td>No. (%)</td><td>OR (95% CI)</td></tr><tr><td>Time window 4</td><td>Lymph nodes</td><td>Case</td><td>165 (98.8)</td><td>2 (1.2)</td><td></td></tr><tr><td></td><td></td><td>MC</td><td>831 (99.5)</td><td>4 (0.5)</td><td>2.50 (0.46–13.72)</td></tr><tr><td></td><td></td><td>UMC</td><td>2,216 (99.6)</td><td>8 (0.4)</td><td>3.13 (0.72–13.69)</td></tr><tr><td></td><td>Blood vessels</td><td>Case</td><td>165 (98.8)</td><td>2 (1.2)</td><td></td></tr><tr><td></td><td></td><td>MC</td><td>828 (99.2)</td><td>7 (0.8)</td><td>1.46 (0.33–6.48)</td></tr><tr><td></td><td></td><td>UMC</td><td>2,217 (99.7)</td><td>7 (0.3)</td><td>3.88 (0.82–18.34)</td></tr><tr><td></td><td>Anterior ophthalmic</td><td>Case</td><td>166 (99.4)</td><td>1 (0.6)</td><td></td></tr><tr><td></td><td>structures</td><td>MC</td><td>833 (99.8)</td><td>2 (0.6)</td><td>2.50 (0.23–27.77)</td></tr><tr><td></td><td></td><td>UMC</td><td>2,217 (99.7)</td><td>7 (0.3)</td><td>1.77 (0.24–13.29)</td></tr><tr><td></td><td>Skeletal muscle</td><td>Case</td><td>164 (98.2)</td><td>3 (1.8)</td><td></td></tr><tr><td></td><td></td><td>MC</td><td>813 (97.4)</td><td>22 (2.6)</td><td>0.68 (0.20–2.29)</td></tr><tr><td></td><td></td><td>UMC</td><td>2,169 (97.5)</td><td>55 (2.5)</td><td>0.57 (0.17–1.89)</td></tr><tr><td></td><td>Peritoneum</td><td>Case</td><td>162 (97.0)</td><td>5 (3.0)</td><td></td></tr><tr><td></td><td></td><td>MC</td><td>826 (98.9)</td><td>9 (1.1)</td><td>2.78 (0.93–8.32)</td></tr><tr><td></td><td></td><td>UMC</td><td>2,194 (98.7)</td><td>30 (1.3)</td><td>2.13 (0.80–5.66)</td></tr><tr><td></td><td>Other tissues</td><td>Case</td><td>161 (96.4)</td><td>6 (3.6)</td><td></td></tr><tr><td></td><td></td><td>MC</td><td>826 (98.9)</td><td>9 (1.1)</td><td>3.51 (1.24–9.96)</td></tr><tr><td></td><td></td><td>UMC</td><td>2,190 (98.5)</td><td>34 (1.5)</td><td>2.02 (0.83–4.93)</td></tr><tr><td>Time window 5</td><td>Brain</td><td>Case</td><td>165 (98.8)</td><td>2 (1.2)</td><td></td></tr><tr><td></td><td></td><td>MC</td><td>835 (100.0)</td><td>0 (0.0)</td><td></td></tr><tr><td></td><td></td><td>UMC</td><td>2,223 (100.0)</td><td>1 (0.0)</td><td>36.35 (1.86–711.57)</td></tr><tr><td></td><td>Dura mater</td><td>Case</td><td>165 (98.8)</td><td>2 (1.2)</td><td></td></tr><tr><td></td><td></td><td>MC</td><td>835 (100.0)</td><td>0 (0.0)</td><td></td></tr></table>
<table><tr><td></td><td></td><td>UMC</td><td>2,223 (100.0)</td><td>1 (0.0)</td><td>36.35 (1.86–711.57)</td></tr><tr><td></td><td>Lymph nodes</td><td>Case</td><td>166 (99.4)</td><td>1 (0.6)</td><td></td></tr><tr><td></td><td></td><td>MC</td><td>831 (99.5)</td><td>4 (0.5)</td><td>1.25 (0.14–11.26)</td></tr><tr><td></td><td></td><td>UMC</td><td>2,218 (99.7)</td><td>6 (0.3)</td><td>2.07 (0.28–15.05)</td></tr><tr><td></td><td>Skeletal muscle</td><td>Case</td><td>161 (96.4)</td><td>6 (3.6)</td><td></td></tr><tr><td></td><td></td><td>MC</td><td>825 (98.8)</td><td>10 (1.2)</td><td>3.13 (1.13–8.65)</td></tr><tr><td></td><td></td><td>UMC</td><td>2,196 (98.7)</td><td>28 (1.3)</td><td>2.76 (1.11–6.89)</td></tr><tr><td></td><td>Peritoneum</td><td>Case</td><td>161 (96.4)</td><td>6 (3.6)</td><td></td></tr><tr><td></td><td></td><td>MC</td><td>832 (99.6)</td><td>3 (0.4)</td><td>10.00 (2.49–40.15)</td></tr><tr><td></td><td></td><td>UMC</td><td>2,210 (99.4)</td><td>14 (0.6)</td><td>5.50 (2.07–14.66)</td></tr><tr><td></td><td>Other tissues</td><td>Case</td><td>166 (99.4)</td><td>1 (0.6)</td><td></td></tr><tr><td></td><td></td><td>MC</td><td>826 (98.9)</td><td>9 (1.1)</td><td>0.56 (0.07–4.41)</td></tr><tr><td></td><td></td><td>UMC</td><td>2,214 (99.6)</td><td>10 (0.4)</td><td>1.66 (0.19–14.86)</td></tr></table>
0a3d6e78b8b9bd57ac14f7b894177f6e679c478fe32d4b197023ed41f3139c77.png
simple
<table><tr><td>Tract</td><td>Wave-1</td><td>Wave-2</td><td><i>P</i>-value</td><td><i>N</i></td><td>% &#916;FA/year</td><td><i>M</i></td></tr><tr><td>ACF</td><td>0.437 &#177; 0.033</td><td>0.420 &#177; 0.028</td><td>&lt;0.001</td><td>74</td><td>&#8722;1.50</td><td>1</td></tr><tr><td>LH CST</td><td>0.434 &#177; 0.025</td><td>0.439 &#177; 0.023</td><td>0.014</td><td>76</td><td>0.49</td><td>0</td></tr><tr><td>RH CST</td><td>0.424 &#177; 0.027</td><td>0.427 &#177; 0.028</td><td>0.058</td><td>74</td><td>0.36</td><td>2</td></tr></table>
<table><tr><td>Tr</td><td>Wav</td><td>W</td><td></td><td></td><td>% </td><td></td></tr></table>
<table><tr><td>act</td><td>e-1</td><td>ave-2</td><td>P-value</td><td>N</td><td>ΔFA/year</td><td>M</td></tr><tr><td>ACF</td><td>0.437 ± 0.033</td><td>0.420 ± 0.028</td><td><0.001</td><td>74</td><td>−1.50</td><td>1</td></tr><tr><td>LH CST</td><td>0.434 ± 0.025</td><td>0.439 ± 0.023</td><td>0.014</td><td>76</td><td>0.49</td><td>0</td></tr><tr><td>RH CST</td><td>0.424 ± 0.027</td><td>0.427 ± 0.028</td><td>0.058</td><td>74</td><td>0.36</td><td>2</td></tr></table>
0e05883e91bcc6c4b0dffdefc66318a1e38681087300f6a3e3f3a0441c69c964.png
simple
<table><tr><td>Variable</td><td>Hazard ratio</td><td>95% CI</td><td><i>P</i>value</td></tr><tr><td>Age</td><td>0.987</td><td>0.938-1.039</td><td>0.611</td></tr><tr><td>Interval time (mos.) from AP</td><td>0.564</td><td>0.147-2.158</td><td>0.403</td></tr><tr><td>Multi-agent failure therapy</td><td>3.177</td><td>1.277-7.908</td><td>0.013</td></tr><tr><td>Liver metastasis</td><td>1.897</td><td>0.787-4.573</td><td>0.154</td></tr><tr><td>Kidney metastasis</td><td>2.654</td><td>1.125-6.261</td><td>0.026</td></tr><tr><td>Craniotomy</td><td>1.835</td><td>0.565-5.962</td><td>0.312</td></tr><tr><td>FIGO score</td><td>1.279</td><td>1.061-1.541</td><td>0.010</td></tr></table>
<table><tr><td>Variable</td><td>Hazard ratio</td><td>95% CI</td><td>Pvalue</td></tr><tr><td>Age</td><td>0.987</td><td>0.938-1.039</td><td>0.611</td></tr><tr><td>Interv</td><td>0.5</td><td>0.147-2.</td><td>0.4</td></tr></table>
<table><tr><td>al time (mos.) from AP</td><td>64</td><td>158</td><td>03</td></tr><tr><td>Multi-agent failure therapy</td><td>3.177</td><td>1.277-7.908</td><td>0.013</td></tr><tr><td>Liver metastasis</td><td>1.897</td><td>0.787-4.573</td><td>0.154</td></tr><tr><td>Kidney metastasis</td><td>2.654</td><td>1.125-6.261</td><td>0.026</td></tr><tr><td>Craniotomy</td><td>1.835</td><td>0.565-5.962</td><td>0.312</td></tr><tr><td>FIGO score</td><td>1.279</td><td>1.061-1.541</td><td>0.010</td></tr></table>
d37b4933e97379222accfd63d3bad8d08fc8b8d85ac33eb75d12f72f5a341426.png
complex
<table><tr><td>Sorghum containing diets</td><td>Dose</td><td>TVFA(mM)</td><td>Acetate(mM)</td><td>Propionate(mM)</td><td>Butyrate(mM)</td></tr><tr><td rowspan="4">HFD (80R : 20C)</td><td>0</td><td>51.5</td><td>34.2</td><td>11.1</td><td>6.3</td></tr><tr><td>5</td><td>62.7</td><td>39.8</td><td>16.2</td><td>6.7</td></tr><tr><td>10</td><td>63.0</td><td>38.7</td><td>18.1</td><td>6.3</td></tr><tr><td>15</td><td>66.2</td><td>40.0</td><td>19.9</td><td>6.3</td></tr><tr><td rowspan="4">MFD (50R : 50C)</td><td>0</td><td>61.8</td><td>40.4</td><td>14.5</td><td>7.0</td></tr><tr><td>5</td><td>58.8</td><td>38.5</td><td>15.3</td><td>5.0</td></tr><tr><td>10</td><td>68.2</td><td>43.4</td><td>19.4</td><td>5.4</td></tr><tr><td>15</td><td>71.5</td><td>42.2</td><td>22.1</td><td>7.2</td></tr><tr><td rowspan="4">LFD (20R : 80C)</td><td>0</td><td>64.5</td><td>43.8</td><td>12.7</td><td>7.9</td></tr><tr><td>5</td><td>70.3</td><td>43.2</td><td>19.5</td><td>7.6</td></tr><tr><td>10</td><td>71.0</td><td>42.4</td><td>21.5</td><td>7.1</td></tr><tr><td>15</td><td>72.7</td><td>41.9</td><td>23.0</td><td>7.7</td></tr><tr><td rowspan="3">SEM</td><td>Diet (D)</td><td>1.04</td><td>0.69</td><td>0.45</td><td>0.19</td></tr><tr><td>Treatment (T)</td><td>1.20</td><td>NS</td><td>0.52</td><td>0.22</td></tr><tr><td>D &#215; T</td><td>NS</td><td>1.38</td><td>NS</td><td>0.04</td></tr></table>
<table><tr><td>Sorghum containing diets</td><td>Dose</td><td>TVFA(mM)</td><td>Acetate(mM)</td><td>Propionate(mM)</td><td>Butyrate(mM)</td></tr><tr><td rowspan="4">HFD (80R : 20C)</td><td>0</td><td>51.5</td><td>34.2</td><td>11.1</td><td>6.3</td></tr><tr><td>5</td><td>62.7</td><td>39.8</td><td>16.2</td><td>6.7</td></tr><tr><td>10</td><td>63.0</td><td>38.7</td><td>18.1</td><td>6.3</td></tr><tr><td>15</td><td>66.2</td><td>40.0</td><td>19.9</td><td>6.3</td></tr><tr><td rowspan="4">MFD (50R : 50C)</td><td>0</td><td>61.8</td><td>40.4</td><td>14.5</td><td>7.0</td></tr><tr><td>5</td><td>58.8</td><td>38.5</td><td>15.3</td><td>5.0</td></tr><tr><td>10</td><td>68.2</td><td>43.4</td><td>19.4</td><td>5.4</td></tr><tr><td>15</td><td>71.5</td><td>42.2</td><td>22.1</td><td>7.2</td></tr></table>
<table><tr><td rowspan="4">LFD (20R : 80C)</td><td>0</td><td>64.5</td><td>43.8</td><td>12.7</td><td>7.9</td></tr><tr><td>5</td><td>70.3</td><td>43.2</td><td>19.5</td><td>7.6</td></tr><tr><td>10</td><td>71.0</td><td>42.4</td><td>21.5</td><td>7.1</td></tr><tr><td>15</td><td>72.7</td><td>41.9</td><td>23.0</td><td>7.7</td></tr><tr><td rowspan="3">SEM</td><td>Diet (D)</td><td>1.04</td><td>0.69</td><td>0.45</td><td>0.19</td></tr><tr><td>Treatment (T)</td><td>1.20</td><td>NS</td><td>0.52</td><td>0.22</td></tr><tr><td>D × T</td><td>NS</td><td>1.38</td><td>NS</td><td>0.04</td></tr></table>
cb54cd6ae2b5f8547cc287935d641231cafb7fdb78b8346b2487fecfb7889a1f.png
simple
<table><tr><td></td><td>N</td><td>(%)</td></tr><tr><td>Uterine atony</td><td>179</td><td>(55)</td></tr><tr><td>Placenta abnormalities;</td><td>173</td><td>(53)</td></tr><tr><td> Retained</td><td>54</td><td>(17)</td></tr><tr><td> Previa</td><td>37</td><td>(11)</td></tr><tr><td> Abnormally invasive placenta</td><td>32</td><td>(10)</td></tr><tr><td> Remnant</td><td>30</td><td>(9)</td></tr><tr><td> Abruption</td><td>20</td><td>(6)</td></tr><tr><td>Laceration;</td><td>40</td><td>(12)</td></tr><tr><td> Vagina</td><td>23</td><td>(7)</td></tr><tr><td> Cervix</td><td>17</td><td>(5)</td></tr><tr><td>Uterine rupture</td><td>20</td><td>(6)</td></tr><tr><td>Iatrogenic during/after cesarean</td><td>11</td><td>(3)</td></tr><tr><td>Other</td><td>22</td><td>(7)</td></tr><tr><td>Unknown</td><td>9</td><td>(3)</td></tr></table>
<table><tr><td></td><td>N</td><td>(%)</td></tr><tr><td>Uterine atony</td><td>179</td><td>(55)</td></tr><tr><td>Placenta abnormalities;</td><td>173</td><td>(53)</td></tr><tr><td></td><td></td><td>(1</td></tr></table>
<table><tr><td></td><td>N</td><td>(%)</td></tr><tr><td>Retained</td><td>54</td><td>7)</td></tr><tr><td>Previa</td><td>37</td><td>(11)</td></tr><tr><td>Abnormally invasive placenta</td><td>32</td><td>(10)</td></tr><tr><td>Remnant</td><td>30</td><td>(9)</td></tr><tr><td>Abruption</td><td>20</td><td>(6)</td></tr><tr><td>Laceration;</td><td>40</td><td>(12)</td></tr><tr><td>Vagina</td><td>23</td><td>(7)</td></tr><tr><td>Cervix</td><td>17</td><td>(5)</td></tr><tr><td>Uterine rupture</td><td>20</td><td>(6)</td></tr><tr><td>Iatrogenic during/after cesarean</td><td>11</td><td>(3)</td></tr><tr><td>Other</td><td>22</td><td>(7)</td></tr><tr><td>Unknown</td><td>9</td><td>(3)</td></tr></table>