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8a630901f6a644d31be0fb34cf9a216e17140e8fc2751ef6c0d98e4deab69db2.png
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<table><tr><td> </td><td>Hazard ratio</td><td><i>P</i> value</td><td>Standard Error</td><td colspan="2">95% CI</td></tr><tr><td>Age</td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td> &lt;40</td><td>Reference</td><td> </td><td> </td><td> </td><td> </td></tr><tr><td> [40, 65)</td><td>1.9754</td><td>0.1070</td><td>0.8354</td><td>0.8623</td><td>4.5250</td></tr><tr><td> &#8805;65</td><td>5.0853</td><td>0.0000</td><td>2.1284</td><td>2.2390</td><td>11.5499</td></tr><tr><td>Gender</td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td> Female</td><td>Reference</td><td> </td><td> </td><td> </td><td> </td></tr><tr><td> Male</td><td>1.4740</td><td>0.0040</td><td>0.1996</td><td>1.1303</td><td>1.9221</td></tr><tr><td>Location</td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td> Stomach</td><td>Reference</td><td> </td><td> </td><td> </td><td> </td></tr><tr><td> Intestine</td><td>1.6092</td><td>0.0010</td><td>0.2322</td><td>1.2127</td><td>2.1353</td></tr><tr><td> Others</td><td>1.9870</td><td>0.0010</td><td>0.4120</td><td>1.3235</td><td>2.9832</td></tr></table>
ae70e57a59a0fca922960177f7f8e110dbe72b08acb305831b1a157bcd3c378f.png
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<table><tr><td></td><td colspan="2">Beginning of treatment</td><td colspan="2">End of treatment</td></tr><tr><td>Patients</td><td>Initial angle</td><td>AOFAS score</td><td>Final angle</td><td>AOFAS score</td></tr><tr><td>1</td><td>1</td><td>40</td><td>1</td><td>80</td></tr><tr><td>2</td><td>10</td><td>41</td><td>10</td><td>74</td></tr><tr><td>3</td><td>7</td><td>40</td><td>8</td><td>72</td></tr><tr><td>4</td><td>8</td><td>39</td><td>9</td><td>76</td></tr><tr><td>5</td><td>15</td><td>38</td><td>17</td><td>74</td></tr><tr><td>6</td><td>15</td><td>40</td><td>16</td><td>73</td></tr><tr><td>7</td><td>10</td><td>38</td><td>12</td><td>75</td></tr><tr><td>8</td><td>9</td><td>40</td><td>10</td><td>75</td></tr><tr><td>9</td><td>9</td><td>41</td><td>9</td><td>74</td></tr><tr><td>10</td><td>11</td><td>40</td><td>11</td><td>76</td></tr><tr><td>11</td><td>10</td><td>42</td><td>10</td><td>70</td></tr><tr><td>12</td><td>11</td><td>40</td><td>11</td><td>72</td></tr><tr><td>13</td><td>9</td><td>41</td><td>9</td><td>76</td></tr><tr><td>14</td><td>6</td><td>44</td><td>6</td><td>79</td></tr><tr><td>15</td><td>6</td><td>39</td><td>7</td><td>77</td></tr><tr><td>16</td><td>3</td><td>43</td><td>4</td><td>78</td></tr><tr><td>17</td><td>6</td><td>40</td><td>7</td><td>77</td></tr><tr><td>18</td><td>7</td><td>42</td><td>8</td><td>78</td></tr><tr><td>19</td><td>9</td><td>39</td><td>10</td><td>73</td></tr><tr><td>20</td><td>9</td><td>41</td><td>9</td><td>74</td></tr><tr><td>21</td><td>6</td><td>44</td><td>5</td><td>70</td></tr><tr><td>22</td><td>7</td><td>40</td><td>7</td><td>78</td></tr></table>
47fad24a2c47b1b9cfad497a1160f919355c718753f378af63cb7a6e580392ba.png
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<table><tr><td rowspan="3">Variable</td><td colspan="3">Disease-Free Survival</td><td colspan="3">Progression-Free Survival</td></tr><tr><td rowspan="2">OverallPopulation67 pts</td><td>BCG</td><td>No BCG</td><td rowspan="2">OverallPopulation63 pts</td><td>BCG</td><td>No BCG</td></tr><tr><td>34 pts</td><td>33 pts</td><td>33 pts</td><td>30 pts</td></tr><tr><td>Male <i>vs</i>. Female</td><td>0.3400</td><td>0.3430</td><td>0.5647</td><td>0.3355</td><td>0.1887</td><td>0.9311</td></tr><tr><td>Primary <i>vs</i>. Recurrent</td><td>0.1926</td><td>0.5363</td><td>0.1614</td><td>0.6409</td><td>0.0519</td><td>0.2591</td></tr><tr><td>Single <i>vs</i>. Multiple</td><td>0.4756</td><td>0.7956</td><td>0.2035</td><td>0.6412</td><td>0.8857</td><td>0.3905</td></tr><tr><td>Size &lt;3cm <i>vs</i>. &gt;3cm</td><td>0.3926</td><td>0.2524</td><td>0.7226</td><td>0.7417</td><td>0.2783</td><td>0.4515</td></tr><tr><td>HER-2 negative <i>vs</i>. HER-2 positive</td><td>0.0013</td><td>0.0140</td><td>0.0125</td><td>0.0322</td><td>0.1290</td><td>0.1696</td></tr></table>
bd85d358ce3011d3c11cf78703a4fa418eeeb39f9c9754a07c2e830582747a5d.png
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<table><tr><td></td><td>Adjusted HR<sup>a</sup></td><td>(95 % CI)</td></tr><tr><td>Without antipsychotics</td><td>1.40</td><td>(1.18, 1.66)</td></tr><tr><td>With antipsychotics</td><td>1.45</td><td>(1.16, 1.82)</td></tr><tr><td>Without anticoagulant</td><td>1.44</td><td>(1.25, 1.65)</td></tr><tr><td>With anticoagulant</td><td>1.24</td><td>(0.76, 2.00)</td></tr><tr><td>Without antiplatelet</td><td>1.41</td><td>(1.23, 1.62)</td></tr><tr><td>With antiplatelet</td><td>1.52</td><td>(0.72, 3.22)</td></tr><tr><td>Without anti-inflammatory</td><td>1.29</td><td>(0.90, 1.85)</td></tr><tr><td>With anti-inflammatory</td><td>1.44</td><td>(1.24, 1.67)</td></tr><tr><td>Without anxiety or other mood disorders</td><td>1.40</td><td>(1.07, 1.82)</td></tr><tr><td>With anxiety or other mood disorders</td><td>1.42</td><td>(1.21, 1.66)</td></tr><tr><td>Without atrial fibrillation</td><td>1.40</td><td>(1.22, 1.62)</td></tr><tr><td>With atrial fibrillation</td><td>1.57</td><td>(0.98, 2.50)</td></tr><tr><td>Without coronary heart disease</td><td>1.36</td><td>(1.16, 1.60)</td></tr><tr><td>With coronary heart disease</td><td>1.59</td><td>(1.24, 2.05)</td></tr><tr><td>Without congestive heart failure</td><td>1.44</td><td>(1.25, 1.65)</td></tr><tr><td>With congestive heart failure</td><td>1.15</td><td>(0.68, 1.97)</td></tr><tr><td>Without chronic obstructive pulmonary disease</td><td>1.49</td><td>(1.29, 1.73)</td></tr><tr><td>With chronic obstructive pulmonary disease</td><td>1.09</td><td>(0.77, 1.54)</td></tr><tr><td>Without cancer</td><td>1.42</td><td>(1.24, 1.63)</td></tr><tr><td>With cancer</td><td>0.94</td><td>(0.26, 3.32)</td></tr><tr><td>Without diabetes mellitus</td><td>1.20</td><td>(0.99, 1.45)</td></tr><tr><td>With diabetes mellitus<sup>+</sup></td><td>1.70</td><td>(1.41, 2.05)</td></tr><tr><td>Without hypertension</td><td>1.25</td><td>(0.69, 2.27)</td></tr><tr><td>With hypertension</td><td>1.42</td><td>(1.24, 1.64)</td></tr><tr><td>Without hyperlipidemia</td><td>1.41</td><td>(1.18, 1.68)</td></tr><tr><td>With hyperlipidemia</td><td>1.42</td><td>(1.15, 1.76)</td></tr><tr><td colspan="3">Antidepressants use before index date</td></tr><tr><td> No--New Users</td><td>1.57</td><td>(1.32, 1.86)</td></tr><tr><td> Yes--Prevalent Users</td><td>1.23</td><td>(0.99, 1.53)</td></tr><tr><td colspan="3">Depression at Baseline (index date) or Post-stroke</td></tr><tr><td> No Depression</td><td>1.55</td><td>(1.32, 1.82)</td></tr><tr><td> Depression at Baseline</td><td>1.49</td><td>(0.99, 2.26)</td></tr><tr><td> Post-stroke Depression</td><td>1.44</td><td>(1.01, 2.07)</td></tr></table>
625ea57cb8108c7a2f5e3545bc4616374624f9aaefbfa303fb01b1030899cf3d.png
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<table><tr><td>Brain regions</td><td colspan="3">Peak MNI, mm</td><td><i>T</i> score</td></tr><tr><td></td><td><i>X</i></td><td><i>Y</i></td><td><i>Z</i></td></tr><tr><td>MHE vs. Controls (FDR corrected, <i>p</i> &lt; 0.05)</td><td></td><td></td><td></td><td></td></tr><tr><td>Right fusiform gyrus</td><td>24</td><td>0</td><td>&#8722;49</td><td>5.11</td></tr><tr><td>Right rectus</td><td>6</td><td>51</td><td>&#8722;21</td><td>4.25</td></tr><tr><td>Right thalamus</td><td>21</td><td>&#8722;26</td><td>0</td><td>&#8722;5.83</td></tr><tr><td>Right superior frontal gyrus</td><td>15</td><td>&#8722;3</td><td>75</td><td>4.43</td></tr><tr><td>Left paracentral lobule</td><td>&#8722;15</td><td>&#8722;36</td><td>75</td><td>4.49</td></tr><tr><td>Right postcentral gyrus</td><td>12</td><td>&#8722;45</td><td>78</td><td>4.59</td></tr><tr><td>Right calcarine</td><td>3</td><td>&#8722;69</td><td>15</td><td>&#8722;3.77</td></tr><tr><td>NMHE vs. Controls (FDR corrected, <i>p</i> &lt; 0.05)</td><td></td><td></td><td></td><td></td></tr><tr><td>Right frontal pole</td><td>6</td><td>54</td><td>&#8722;27</td><td>4.22</td></tr><tr><td>Right superior frontal gyrus</td><td>12</td><td>&#8722;12</td><td>78</td><td>4.51</td></tr><tr><td>Right thalamus</td><td>18</td><td>&#8722;27</td><td>0</td><td>&#8722;4.15</td></tr><tr><td>Right calcarine</td><td>6</td><td>&#8722;69</td><td>18</td><td>&#8722;4.84</td></tr><tr><td>Left precentral gyrus</td><td>&#8722;27</td><td>&#8722;21</td><td>72</td><td>5.18</td></tr><tr><td>Left middle frontal gyrus</td><td>&#8722;42</td><td>30</td><td>45</td><td>5.60</td></tr><tr><td>MHE vs. NMHE (uncorrected, <i>p</i> &lt; 0.001)</td><td></td><td></td><td></td><td></td></tr><tr><td>Right postcentral gyrus</td><td>18</td><td>&#8722;39</td><td>75</td><td>3.53</td></tr></table>
e5b6c52679009115d36436f74a7db7c46eb9c1f2e0cba61f42d2f199d9655906.png
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<table><tr><td></td><td>Not Overusing Medication <i>n</i> = 11,542</td><td>Overusing Medication <i>n</i> = 2107</td><td>Total Sample <i>n</i> = 13,649</td><td>Chi</td><td><i>P</i>-value</td></tr><tr><td colspan="6">Sex</td></tr><tr><td> Men</td><td>3074 (26.6)</td><td>621 (29.5)</td><td>3695 (27.1)</td><td>7.136</td><td>0.008</td></tr><tr><td> Women</td><td>8468 (73.4)</td><td>1486 (70.5)</td><td>9954 (72.9)</td><td></td><td></td></tr><tr><td>Age<sup>b</sup>, years (mean &#177; SD)</td><td>43.0 &#177; 13.6</td><td>45.8 &#177; 13.2</td><td>43.41 &#177; 13.62</td><td>8.891</td><td>&lt; 0.001</td></tr><tr><td colspan="6">Age group, years</td></tr><tr><td> 18&#8211;24</td><td>899 (7.8)</td><td>80 (3.8)</td><td>979 (7.2)</td><td>96.346</td><td>&lt; 0.001</td></tr><tr><td> 25&#8211;34</td><td>2831 (24.5)</td><td>409 (19.4)</td><td>3240 (23.7)</td><td></td><td></td></tr><tr><td> 35&#8211;44</td><td>2775 (24.0)</td><td>518 (24.6)</td><td>3293 (24.1)</td><td></td><td></td></tr><tr><td> 45&#8211;54</td><td>2566 (22.2)</td><td>546 (25.9)</td><td>3112 (22.8)</td><td></td><td></td></tr><tr><td> 55&#8211;64</td><td>1572 (13.6)</td><td>348 (16.5)</td><td>1920 (14.1)</td><td></td><td></td></tr><tr><td> 65&#8211;74</td><td>815 (7.1)</td><td>184 (8.7)</td><td>999 (7.3)</td><td></td><td></td></tr><tr><td> 75+</td><td>84 (0.7)</td><td>22 (1.0)</td><td>106 (0.8)</td><td></td><td></td></tr><tr><td colspan="6">Married</td></tr><tr><td> No</td><td>5261 (45.7)</td><td>867 (41.4)</td><td>6128 (45.1)</td><td>13.436</td><td>&lt; 0.001</td></tr><tr><td> Yes</td><td>6245 (54.3)</td><td>1229 (58.6)</td><td>7474 (54.9)</td><td></td><td></td></tr><tr><td colspan="6">Race</td></tr><tr><td> Non-Caucasian</td><td>2091 (18.2)</td><td>361 (17.2)</td><td>2452 (18.1)</td><td>1.166</td><td>0.280</td></tr><tr><td> Caucasian</td><td>9379 (81.8)</td><td>1736 (82.8)</td><td>11,115 (81.9)</td><td></td><td></td></tr><tr><td colspan="6">Household income, $</td></tr><tr><td>&lt; 25,000</td><td>1254 (11.2)</td><td>292 (14.2)</td><td>1546 (11.6)</td><td>17.025</td><td>0.002</td></tr><tr><td> 25,000&#8211;49,999</td><td>2422 (21.6)</td><td>444 (21.6)</td><td>2866 (21.6)</td><td></td><td></td></tr><tr><td> 50,000&#8211;74,999</td><td>2493 (22.2)</td><td>437 (21.3)</td><td>2930 (22.1)</td><td></td><td></td></tr><tr><td> 75,000&#8211;99,999</td><td>1986 (17.7)</td><td>363 (17.7)</td><td>2349 (17.7)</td><td></td><td></td></tr><tr><td>&#8805; 100,000</td><td>3070 (27.3)</td><td>516 (25.1)</td><td>3586 (27.0)</td><td></td><td></td></tr><tr><td colspan="6">Education, &#8805;4-year college degree</td></tr><tr><td> No</td><td>4612 (40.0)</td><td>1018 (48.3)</td><td>5630 (41.2)</td><td>51.000</td><td>&lt; 0.001</td></tr><tr><td> Yes</td><td>6930 (60.0)</td><td>1089 (51.7)</td><td>8019 (58.8)</td><td></td><td></td></tr><tr><td>BMI<sup>b</sup>, kg/m<sup>2</sup> (mean &#177; SD)</td><td>28.1 &#177; 7.4</td><td>28.9 &#177; 8.5</td><td>28.3 &#177; 7.6</td><td>4.380</td><td>&lt; 0.001</td></tr><tr><td colspan="6">BMI category</td></tr><tr><td> Underweight</td><td>329 (2.9)</td><td>94 (4.5)</td><td>423 (3.1)</td><td>44.240</td><td>&lt; 0.001</td></tr><tr><td> Normal</td><td>4154 (36.0)</td><td>645 (30.6)</td><td>4799 (35.2)</td><td></td><td></td></tr><tr><td> Overweight</td><td>3387 (29.3)</td><td>588 (27.9)</td><td>3975 (29.1)</td><td></td><td></td></tr><tr><td> Obese</td><td>3672 (31.8)</td><td>780 (37.0)</td><td>4452 (32.6)</td><td></td><td></td></tr><tr><td colspan="6">Health insurance</td></tr><tr><td> No</td><td>945 (8.2)</td><td>184 (8.7)</td><td>1129 (8.3)</td><td>0.628</td><td>0.428</td></tr><tr><td> Yes</td><td>10,597 (91.8)</td><td>1923 (91.3)</td><td>12,520 (91.7)</td><td></td><td></td></tr><tr><td colspan="6">Psychological symptoms<sup>c</sup></td></tr><tr><td> No</td><td>9210 (79.8)</td><td>1275 (60.5)</td><td>10,485 (76.8)</td><td>370.957</td><td>&lt; 0.001</td></tr><tr><td> Yes</td><td>2332 (20.2)</td><td>832 (39.5)</td><td>3164 (23.2)</td><td></td><td></td></tr><tr><td colspan="6">Current smoker</td></tr><tr><td> No</td><td>10,387 (90.0)</td><td>1718 (81.5)</td><td>12,105 (88.7)</td><td>126.127</td><td>&lt; 0.001</td></tr><tr><td> Yes</td><td>1155 (10.0)</td><td>389 (18.5)</td><td>1544 (11.3)</td><td></td><td></td></tr></table>
7bf5cbff7686f00aaa76e5c692d7ea62768d02139dc3812f175bd7c50166644f.png
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<table><tr><td>Trial</td><td>MEK Inhibitor</td><td>PI3K Inhibitor</td><td>Phase</td><td>Population</td></tr><tr><td>NCT01363232</td><td>MEK162</td><td>BKM120</td><td>Phase I</td><td>Patients with advanced solid cancers (colorectal cancer, triple-negative breast cancer, pancreatic cancer, and other cancers harboring KRAS, BRAF and NRAS mutations)</td></tr><tr><td>NCT01392521</td><td>BAY86-9766</td><td>BAY80-6946</td><td>Phase Ib</td><td>Patients with advanced solid cancers</td></tr><tr><td>NCT01449058</td><td>MEK162</td><td>BYL719</td><td>Phase II</td><td>Patients with advanced solid cancers (colorectal cancer, esophageal cancer, pancreatic cancer, non-small cell lung cancer, and other advanced solid tumors harboring RAS or BRAF mutations)</td></tr><tr><td>Trial</td><td>MEK Inhibitor</td><td>PI3K/mTOR Inhibitor</td><td>Phase</td><td>Population</td></tr><tr><td>NCT00996892</td><td>GDC-0973</td><td>Pictilisb (GDC-0941)</td><td>Phase I</td><td>Patients with advanced solid cancers</td></tr><tr><td>NCT01337765</td><td>MEK162</td><td>BEZ235</td><td>Phase 1</td><td>Patients with advanced solid cancers (colorectal cancer, triple-negative breast cancer, pancreatic cancer, malignant melanoma, non-small cell lung cancer, and other cancers harboring KRAS, BRAF and NRAS mutation)</td></tr><tr><td>NCT01390818</td><td>Pimasertib (MSC1936369B)</td><td>SAR245409</td><td>Phase 1</td><td>Patients with advanced solid cancers (colorectal cancer, pancreatic cancer, thyroid cancer, non-small cell lung cancer, renal cancer, breast cancer, melanoma, ovarian cancer) and any cancer diagnosed with aberrations in one or more the following genes: PTEN, BRAF, KRAS, NRAS, PI3KCA, ErbB1, ErbB2)</td></tr><tr><td>NCT01347866</td><td>PD0325901</td><td>PF-05212384</td><td>Phase 1</td><td>Patients with advanced solid cancers harboring KRAS or BRAF mutation and patients with KRAS mutation with no more than one prior systemic therapy regimen</td></tr><tr><td>Trial</td><td>MEK Inhibitor</td><td>AKT Inhibitor</td><td>Phase</td><td>Population</td></tr><tr><td>NCT01562275</td><td>GDC-0973</td><td>GDC-0068</td><td>Phase 1</td><td>Patients with locally advanced or metastatic solid tumors</td></tr></table>
909aa5e7ed97c5d47342569a1e8951d7eb774181a3e7668e533630853b3270be.png
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<table><tr><td> </td><td colspan="4">Day 3</td><td colspan="4">Day 5</td></tr><tr><td>Chemicals</td><td>ET</td><td>TO</td><td>CP</td><td>CP + PM</td><td>ET</td><td>TO</td><td>CP</td><td>CP + PM</td></tr><tr><td>Number</td><td>11</td><td>11</td><td>12</td><td>11</td><td>9</td><td>9</td><td>12</td><td>10</td></tr><tr><td>Mean (&#956;m)</td><td>725.3</td><td>785.2</td><td>401.2</td><td>487</td><td>1528.8</td><td>1751.6</td><td>718.4</td><td>1168.2</td></tr><tr><td>SD</td><td>209.3</td><td>225.7</td><td>171.9</td><td>134.1</td><td>375.2</td><td>408.1</td><td>219</td><td>293.1</td></tr><tr><td>P-value (ET)</td><td>-</td><td>0.26</td><td>0.2 E-4</td><td>2.4 E-3</td><td>-</td><td>0.12</td><td>2.7 E-6</td><td>1.6 E-2</td></tr><tr><td>P-value (TO)</td><td>-</td><td>-</td><td>7.5 E-5</td><td>6.1 E-4</td><td>-</td><td>-</td><td>2.2 E-7</td><td>1.1 E-2</td></tr><tr><td>P-value (CP)</td><td>-</td><td>-</td><td>-</td><td>0.1</td><td>-</td><td>-</td><td>-</td><td>2.7 E-4</td></tr></table>
a29b4b3eb79a2910e4af8b8ff3d484b0da55427084e5bfc6a5a168d84e0b7b24.png
complex
<table><tr><td>Checklist item</td><td>Condition</td><td>Session observed</td><td>Outcome</td></tr><tr><td rowspan="2">Timing from first slide to class exercise</td><td>Contact</td><td>First module</td><td>10&#8211;12 min</td></tr><tr><td>Education</td><td>Second module</td><td>10&#8211;26 min</td></tr><tr><td rowspan="2">Time allocated to first exercise</td><td>Contact</td><td>First module</td><td>8&#8211;13 min</td></tr><tr><td>Education</td><td>Second module</td><td>5&#8211;10 min</td></tr><tr><td rowspan="2">Are any slides skipped?</td><td>Contact</td><td>First module</td><td>No, in all observed classes.</td></tr><tr><td>Education</td><td>Second module</td><td>No, in all observed classes.</td></tr><tr><td rowspan="2">Are pupils asked if they have questions?</td><td>Contact</td><td>First module</td><td>Yes, in all observed classes.</td></tr><tr><td>Education</td><td>Second module</td><td>Yes, in all observed classes.</td></tr><tr><td rowspan="2">Are the majority of students engaging in class?</td><td>Contact</td><td>First module</td><td>Yes, in all observed classes.</td></tr><tr><td>Education</td><td>Second module</td><td>Yes, in all observed classes.</td></tr><tr><td rowspan="2">Size of group for first exercise</td><td>Contact</td><td>First module</td><td>2&#8211;7</td></tr><tr><td>Education</td><td>Second module</td><td>3&#8211;5</td></tr><tr><td rowspan="2">Does a facilitator visit each group during exercise?</td><td>Contact</td><td>First module</td><td>Yes, in all observed classes.</td></tr><tr><td>Education</td><td>Second module</td><td>Yes, in all observed classes.</td></tr><tr><td rowspan="2">Do all groups manage to finish exercise in allocated time?</td><td>Contact</td><td>First module</td><td>Yes in 4 observed classes, no in 2 observed classes.</td></tr><tr><td>Education</td><td>Second module</td><td>Yes, in all observed classes.</td></tr></table>
e515d26617492bf60528c0bb273af83a2d2cf4df07c58b5e226e2bfa45747a2c.png
complex
<table><tr><td>Age groups</td><td colspan="3">Men</td><td colspan="3">Women</td><td>P-value<sup>3</sup></td></tr><tr><td> </td><td>Total n</td><td>Prevalence % (95% CI)1</td><td>P-value<sup>2</sup></td><td>Total n</td><td>Prevalence % (95% CI)1</td><td>P-value<sup>2</sup></td><td> </td></tr><tr><td>Poor self-rated health</td><td> </td><td> </td><td>0.7503</td><td> </td><td> </td><td>0.4270</td><td> </td></tr><tr><td>60</td><td>218</td><td>9.4 (5.8 - 14.8)</td><td> </td><td>256</td><td>10.3 (7.0 - 15.0)</td><td> </td><td>0.7328</td></tr><tr><td>65</td><td>132</td><td>12.9 (7.6 - 20.8)</td><td> </td><td>214</td><td>12.3 (7.7 - 18.9)</td><td> </td><td>0.8865</td></tr><tr><td>70</td><td>117</td><td>13.7 (8.5 - 21.4)</td><td> </td><td>164</td><td>12.6 (8.5 - 18.3)</td><td> </td><td>0.8102</td></tr><tr><td>75</td><td>82</td><td>14.8 (7.3 - 27.6)</td><td> </td><td>136</td><td>16.9 (10.9 - 25.2)</td><td> </td><td>0.7250</td></tr><tr><td>80+</td><td>66</td><td>12.0 (5.6 - 23.6)</td><td> </td><td>134</td><td>10.9 (6.4 - 18.1)</td><td> </td><td>0.8248</td></tr><tr><td>Global limitations</td><td> </td><td> </td><td>0.0001</td><td> </td><td> </td><td>0.0000</td><td> </td></tr><tr><td>60</td><td>218</td><td>26.3 (16.6 - 39.0)</td><td> </td><td>256</td><td>32.8 (24.9 - 41.9)</td><td> </td><td>0.1984</td></tr><tr><td>65</td><td>132</td><td>28.5 (19.6 - 39.4)</td><td> </td><td>214</td><td>37.4 (30.8 - 44.4)</td><td> </td><td>0.0808</td></tr><tr><td>70</td><td>117</td><td>43.0 (32.9 - 53.6)</td><td> </td><td>164</td><td>54.2 (43.7 - 64.4)</td><td> </td><td>0.0949</td></tr><tr><td>75</td><td>82</td><td>48.5 (33.9 - 63.5)</td><td> </td><td>136</td><td>60.6 (52.2 - 68.4)</td><td> </td><td>0.1107</td></tr><tr><td>80+</td><td>66</td><td>55.3 (41.0 - 68.8)</td><td> </td><td>134</td><td>74.1 (64.3 - 82.0)</td><td> </td><td>0.0060</td></tr><tr><td>Mild and moderate limitations</td><td> </td><td> </td><td>0.0098</td><td> </td><td> </td><td>0.0000</td><td> </td></tr><tr><td>60</td><td>218</td><td>21.4 (12.2-34.6)</td><td> </td><td>256</td><td>26.4 (19.1-35.3)</td><td> </td><td>0.2964</td></tr><tr><td>65</td><td>132</td><td>23.1 (14.9-33.9)</td><td> </td><td>214</td><td>31.8 (25.5-38.8)</td><td> </td><td>0.0745</td></tr><tr><td>70</td><td>117</td><td>35.3 (25.1-47.1)</td><td> </td><td>164</td><td>37.3 (27.5-48.2)</td><td> </td><td>0.7332</td></tr><tr><td>75</td><td>82</td><td>33.7 (22.0-47.9)</td><td> </td><td>136</td><td>48.9 (39.7-58.1)</td><td> </td><td>0.0499</td></tr><tr><td>80+</td><td>66</td><td>40.5 (28.0-54.3)</td><td> </td><td>134</td><td>43.1 (34.3-52.4)</td><td> </td><td>0.6706</td></tr><tr><td>Severe limitations</td><td> </td><td> </td><td>0.0201</td><td> </td><td> </td><td>0.0000</td><td> </td></tr><tr><td>60</td><td>218</td><td>4.9 (2.4-10.0)</td><td> </td><td>256</td><td>6.4 (3.5-11.5)</td><td> </td><td>0.4862</td></tr><tr><td>65</td><td>132</td><td>5.4 (2.4-11.5)</td><td> </td><td>214</td><td>5.6 (3.4-9.0)</td><td> </td><td>0.9551</td></tr><tr><td>70</td><td>117</td><td>7.6 (4.1-13.6)</td><td> </td><td>164</td><td>17.0 (10.8-25.7)</td><td> </td><td>0.0258</td></tr><tr><td>75</td><td>82</td><td>14.8 (7.5-27.0)</td><td> </td><td>136</td><td>11.7 (7.1-18.8)</td><td> </td><td>0.5554</td></tr><tr><td>80+</td><td>66</td><td>14.9 (8.4-25.0)</td><td> </td><td>134</td><td>31.1 (23.4-39.9)</td><td> </td><td>0.0089</td></tr></table>
b072604e1660aed5e157d66eba4c1b2b389491268d20aabf7a2c27a9d567e388.png
complex
<table><tr><td rowspan="2">Perceived stress variables</td><td colspan="3">Factor loading</td></tr><tr><td>Factor 1</td><td>Factor 2</td><td>Factor 3</td></tr><tr><td><i>Pressure and demands</i></td><td>Eigenvalue 5.97 Cronbach&#8217;s alpha 0.83</td><td> </td><td> </td></tr><tr><td>I don&#8217;t have enough time</td><td>0.754</td><td> </td><td> </td></tr><tr><td>I feel under pressure from school demands</td><td>0.698</td><td> </td><td> </td></tr><tr><td>I feel helpless</td><td>0.671</td><td> </td><td> </td></tr><tr><td>I never feel really free</td><td>0.641</td><td> </td><td> </td></tr><tr><td>I feel under pressure from demands at home</td><td>0.563</td><td> </td><td> </td></tr><tr><td>I feel under pressure from my inner demands</td><td>0.536</td><td> </td><td> </td></tr><tr><td>I don&#8217;t feel rested after sleep</td><td>0.531</td><td> </td><td> </td></tr><tr><td><i>Activation/high tempo</i></td><td> </td><td>Eigenvalue 1.41 Cronbach&#8217;s alpha 0.72</td><td> </td></tr><tr><td>I rush even if I don&#8217;t have to</td><td> </td><td>0.721</td><td> </td></tr><tr><td>I keep a high speed all the day</td><td> </td><td>0.700</td><td> </td></tr><tr><td>I eat rapidly even if I don&#8217;t have to</td><td> </td><td>0.576</td><td> </td></tr><tr><td>I do many things at the same time</td><td> </td><td>0.551</td><td> </td></tr><tr><td>I find it difficult to relax</td><td> </td><td>0.533</td><td> </td></tr><tr><td><i>Sleep problems</i></td><td> </td><td> </td><td>Eigenvalue 1.04 Cronbach&#8217;s alpha 0.82</td></tr><tr><td>I sleep restlessly and shallow</td><td> </td><td> </td><td>0.763</td></tr><tr><td>I have difficulty falling asleep</td><td> </td><td> </td><td>0.739</td></tr><tr><td>I wake up early in the morning</td><td> </td><td> </td><td>0.606</td></tr><tr><td>I feel restless</td><td> </td><td> </td><td>0.524</td></tr></table>
783f4124885f6943500fe17911ace4fb65416230aa0aac37ff0fba959815072f.png
complex
<table><tr><td></td><td colspan="3">QubitTM</td><td colspan="4">Spike-in QubitTM</td></tr><tr><td>Kit</td><td>Sample vol. (&#956;L)</td><td>Reading (pg/&#956;L)</td><td>[RNA] (pg/&#956;L)</td><td>Sample Vol. (&#956;L)</td><td>Reading &#177; SD (pg/&#956;L)</td><td>[RNA] &#177; SD (pg/&#956;L)</td><td>CV</td></tr><tr><td>1</td><td>20</td><td>&lt;20</td><td>N.D.</td><td>10</td><td>5.3 &#177; 0.7</td><td>106.0 &#177; 14.0</td><td>13.2%</td></tr><tr><td>2</td><td>20</td><td>&lt; 20</td><td>N.D.</td><td>15</td><td>13.2 &#177; 1.8</td><td>176.4 &#177; 23.4</td><td>13.3%</td></tr><tr><td>3</td><td>20</td><td>&lt; 20</td><td>N.D.</td><td>15</td><td>6.0 &#177; 0.3</td><td>80.0 &#177; 3.5</td><td>4.4%</td></tr></table>
b8e1f7e1afa55a4be42c29472c3e257563d064159148dbcd64e70945d9742a9b.png
complex
<table><tr><td colspan="2">Risk factor</td></tr><tr><td>Curve progression</td><td>Female genderLarge curve magnitudeSkeletal immaturity</td></tr><tr><td>Female body type</td><td>Much thinnerDecreased body weightDecreased chest girthDecreased body mass index</td></tr></table>
4b8ffd9b21b1f5b38265cbe6b55c3ad15bb6f550bd27f2174ecc9511ca2791bd.png
simple
<table><tr><td><i>N</i><sup><i>o </i></sup><i>of patients with antibodies against:</i></td><td>IL-10</td><td>IL-10R1</td><td>IL-10R2</td><td>IL-10 + IL-10R1</td><td>IL-10 + IL-10R2</td><td>IL-10 + IL-10R1 + IL-10R2</td></tr><tr><td><i>IgG</i></td><td>3</td><td>2</td><td>1</td><td>1</td><td>2</td><td>1</td></tr><tr><td><i>IgA</i></td><td>2</td><td>-</td><td>-</td><td>1<sup>1</sup></td><td>-</td><td>-</td></tr><tr><td><i>Total n</i><sup><i>o</i></sup><i>of patients</i></td><td>5</td><td>2</td><td>1</td><td>2</td><td>2</td><td>1</td></tr></table>
c63f172b1c765b93f2a74672f399b9d844d01a35b3b29fced0fc277652e2b110.png
simple
<table><tr><td>Group to group</td><td>24 h</td><td>36 h</td><td>48 h</td></tr><tr><td>M to N (N to M)</td><td>0.0829531</td><td>0.5042984</td><td>0.719462</td></tr><tr><td>A to N</td><td>0.0817174</td><td>0.5047401</td><td>0.728083</td></tr><tr><td>B to N</td><td>0.0851343</td><td>0.4010343</td><td>0.6504139</td></tr><tr><td>C to N</td><td>0.0323821</td><td>0.2762745</td><td>0.4558273</td></tr><tr><td>D to N</td><td>0.015723</td><td>0.1084588</td><td>0.1745785</td></tr><tr><td>E to N</td><td>0.0025864</td><td>0.0368022</td><td>0.0314098</td></tr><tr><td>F to N</td><td>0.0268291</td><td>0.1468612</td><td>0.3239829</td></tr><tr><td>G to N</td><td>0.0013232</td><td>0.0237961</td><td>0.0298026</td></tr><tr><td>A to M</td><td>0.0000178</td><td>0.0000031</td><td>0.0000308</td></tr><tr><td>B to M</td><td>0.0001493</td><td>0.0104849</td><td>0.0024807</td></tr><tr><td>C to M</td><td>0.028301</td><td>0.00672042</td><td>0.0430982</td></tr><tr><td>D to M</td><td>0.0780845</td><td>0.2296862</td><td>0.1965076</td></tr><tr><td>E to M</td><td>0.0578047</td><td>0.2727777</td><td>0.4580789</td></tr><tr><td>F to M</td><td>0.0210222</td><td>0.1120853</td><td>0.0879489</td></tr><tr><td>G to M</td><td>0.0769024</td><td>0.3455155</td><td>0.4808165</td></tr></table>
03f5d78c0c306df448bfc5977e693e13089ddb37e0e89d1344530497fa72d4b5.png
simple
<table><tr><td>Characteristics</td><td>Frequency</td><td>Percentage</td></tr><tr><td><i>Ever donated blood</i></td><td>126</td><td>29.9</td></tr><tr><td><i>Frequency of donation in lifetime </i>(<i>N</i> = 126)</td><td> </td><td> </td></tr><tr><td> Once</td><td>57</td><td>45.2</td></tr><tr><td> Repeated</td><td>69</td><td>54.8</td></tr><tr><td><i>Donated in the past 5 years</i></td><td>124</td><td>98.4</td></tr><tr><td><i>Donated in the past 12 months</i></td><td>123</td><td>97.6</td></tr><tr><td><i>Types of donation</i></td><td> </td><td> </td></tr><tr><td> Voluntary</td><td>114</td><td>90.5</td></tr><tr><td> Paid</td><td>2</td><td>1.6</td></tr><tr><td> Replacement</td><td>10</td><td>7.9</td></tr><tr><td><i>Main reason(s) for the last time donation</i></td><td> </td><td> </td></tr><tr><td> Voluntarism</td><td>114</td><td>90.5</td></tr><tr><td> HIV results</td><td>2</td><td>1.6</td></tr><tr><td> Replacement</td><td>10</td><td>7.9</td></tr><tr><td><i>Would you donate blood again in the future?</i></td><td> </td><td> </td></tr><tr><td> Yes</td><td>120</td><td>95.2</td></tr><tr><td> No</td><td>6</td><td>4.8</td></tr><tr><td><i>The place of your last donation</i></td><td> </td><td> </td></tr><tr><td> Blood Transfusion Centre</td><td>15</td><td>12</td></tr><tr><td> Hospital</td><td>28</td><td>22.4</td></tr><tr><td> School</td><td>82</td><td>65.6</td></tr><tr><td><i>Experienced negative effect after donation</i></td><td> </td><td> </td></tr><tr><td> Yes</td><td>39</td><td>31</td></tr><tr><td> No</td><td>87</td><td>69</td></tr><tr><td><i>Postdonation negative effect </i>(<i>N</i> = 39)</td><td> </td><td> </td></tr><tr><td> Pain</td><td>1</td><td>1</td></tr><tr><td> Dizziness</td><td>37</td><td>94.9</td></tr><tr><td> Fever</td><td>1</td><td>2.6</td></tr></table>
317cfef5aa1b0ca1ef129ccf8be934cc7e7f79e85f3ab322c9e87aa83356f382.png
complex
<table><tr><td></td><td></td><td colspan="4">CM<sub>I</sub></td></tr><tr><td>n</td><td>L</td><td>2</td><td>3</td><td>4</td><td>5</td></tr><tr><td>10</td><td>1000</td><td>0.308</td><td>0.928</td><td>1.000</td><td>1.000</td></tr><tr><td></td><td></td><td>(0.279-0.337)</td><td>(0.912-0.944)</td><td>-</td><td>-</td></tr><tr><td></td><td>5000</td><td>0.363</td><td>0.973</td><td>1.000</td><td>1.000</td></tr><tr><td></td><td></td><td>(0.333-0.393</td><td>(0.963-0.983)</td><td>-</td><td>-</td></tr><tr><td></td><td>10 000</td><td>0.383</td><td>0.966</td><td>1.000</td><td>1.000</td></tr><tr><td></td><td></td><td>(0.353-0.413)</td><td>(0.955-0.977)</td><td>-</td><td>-</td></tr><tr><td></td><td>20 000</td><td>0.380</td><td>0.974</td><td>1.000</td><td>1.000</td></tr><tr><td></td><td></td><td>(0.350-0.410)</td><td>(0.964-0.984)</td><td>-</td><td>-</td></tr><tr><td>25</td><td>1000</td><td>0.569</td><td>1.000</td><td>1.000</td><td>1.000</td></tr><tr><td></td><td></td><td>(0.538-0.600)</td><td>-</td><td>-</td><td>-</td></tr><tr><td></td><td>5000</td><td>0.662</td><td>1.000</td><td>1.000</td><td>1.000</td></tr><tr><td></td><td></td><td>(0.633-0.691)</td><td>-</td><td>-</td><td>-</td></tr><tr><td></td><td>10 000</td><td>0.675</td><td>1.000</td><td>1.000</td><td>1.000</td></tr><tr><td></td><td></td><td>(0.646-0.704)</td><td>-</td><td>-</td><td>-</td></tr><tr><td></td><td>20 000</td><td>0.682</td><td>1.000</td><td>1.000</td><td>1.000</td></tr><tr><td></td><td></td><td>(0.653-0.711)</td><td>-</td><td>-</td><td>-</td></tr><tr><td>50</td><td>1000</td><td>0.740</td><td>1.000</td><td>1.000</td><td>1.000</td></tr><tr><td></td><td></td><td>(0.715-0.769)</td><td>-</td><td>-</td><td>-</td></tr><tr><td></td><td>5000</td><td>0.851</td><td>1.000</td><td>1.000</td><td>1.000</td></tr><tr><td></td><td></td><td>(0.829-0.873)</td><td>-</td><td>-</td><td>-</td></tr><tr><td></td><td>10 000</td><td>0.869</td><td>1.000</td><td>1.000</td><td>1.000</td></tr><tr><td></td><td></td><td>(0.848-0.890)</td><td>-</td><td>-</td><td>-</td></tr><tr><td></td><td>20 000</td><td>0.898</td><td>1.000</td><td>1.000</td><td>1.000</td></tr><tr><td></td><td></td><td>(0.880-0.917)</td><td>-</td><td>-</td><td>-</td></tr><tr><td>100</td><td>1000</td><td>0.890*</td><td>1.000*</td><td>1.000*</td><td>1.000*</td></tr><tr><td></td><td></td><td>(0.828-0.952)</td><td>-</td><td>-</td><td>-</td></tr><tr><td></td><td>5000</td><td>0.970*</td><td>1.000*</td><td>1.000*</td><td>1.000*</td></tr><tr><td></td><td></td><td>(0.936-1.000)</td><td>-</td><td>-</td><td>-</td></tr><tr><td></td><td>10 000</td><td>0.970*</td><td>1.000*</td><td>1.000*</td><td>1.000*</td></tr><tr><td></td><td></td><td>(0.936-1.000)</td><td>-</td><td>-</td><td>-</td></tr><tr><td></td><td>20 000</td><td>0.970*</td><td>1.000*</td><td>1.000*</td><td>1.000*</td></tr><tr><td></td><td></td><td>(0.936-1.000)</td><td>-</td><td>-</td><td>-</td></tr></table>
7054da14611f1f3f5f42a5f998bf0c60c40b5385eb40a9e4f9f5a4425b5e0d01.png
simple
<table><tr><td>Severity criteria</td><td>Score</td></tr><tr><td>Smoking status</td><td> </td></tr><tr><td> Never-smoker</td><td>0</td></tr><tr><td> Smoker</td><td>1</td></tr><tr><td>Symptoms</td><td> </td></tr><tr><td> No</td><td>0</td></tr><tr><td> Yes</td><td>1</td></tr><tr><td>PaO<sub>2</sub>, mmHg</td><td> </td></tr><tr><td> &#8805;80</td><td>0</td></tr><tr><td> 60&#8211;80</td><td>1</td></tr><tr><td> &lt;60</td><td>2</td></tr><tr><td>HRCT score</td><td> </td></tr><tr><td> &#8804;8</td><td>1</td></tr><tr><td> 8&#8211;16 </td><td>2</td></tr><tr><td> 16&#8211;24</td><td>3</td></tr><tr><td> 24&#8211;32</td><td>4</td></tr><tr><td>DLCO, % predicted</td><td> </td></tr><tr><td> &#8805;80</td><td>0</td></tr><tr><td> 60&#8211;80</td><td>1</td></tr><tr><td> &lt;60</td><td>2</td></tr></table>
707b121b2ba5e8462a7d80fac72f969ecf33aaccb6a6317024bd5d616b5bcf51.png
simple
<table><tr><td></td><td>Body weight <i>(</i>grams)</td><td>Cholesterol (mg/dL)</td></tr><tr><td>C57BL/6</td><td>30 &#177; 1</td><td>91 &#177; 5</td></tr><tr><td>AS (15 weeks)</td><td>31 &#177; 2</td><td>749 &#177; 148</td></tr><tr><td>AS (30&#8211;35 weeks)</td><td>28 &#177; 1</td><td>596 &#177; 52</td></tr><tr><td>AS + apocynin (34&#8211;35 weeks)</td><td>28 &#177; 1</td><td>592 &#177; 155</td></tr></table>
8dcf096c1218d1b3d23a76a5862e87c154390e236585c6d68f2c30c8fea6c810.png
complex
<table><tr><td colspan="3"><i>Phytophthora infestans</i></td><td colspan="3"><i>Phytophthora sojae</i></td><td colspan="3"><i>Phytophthora ramorum</i></td></tr><tr><td>PITG accession number</td><td>Predicted intron number</td><td>Predicted length (residues)</td><td>Ps accession number</td><td>Predicted intron number</td><td>Predicted length (residues)</td><td>Pr accession number</td><td>Predicted intron number</td><td>Predicted length (residues)</td></tr><tr><td>09387</td><td>2</td><td>815</td><td>109366</td><td>0</td><td>393</td><td>72239</td><td>0</td><td>389</td></tr><tr><td>12357</td><td>0</td><td>469</td><td>144332</td><td>0</td><td>472</td><td>84847</td><td>0</td><td>469</td></tr><tr><td>-</td><td>-</td><td>-</td><td>157552</td><td>5</td><td>379</td><td>77872</td><td>8</td><td>698</td></tr><tr><td>05114</td><td>2</td><td>545</td><td>132274</td><td>1</td><td>573</td><td>82845</td><td>1</td><td>548</td></tr><tr><td>10524</td><td>0</td><td>737</td><td>138576</td><td>0</td><td>751</td><td>84399</td><td>0</td><td>753</td></tr><tr><td>04975</td><td>1</td><td>512</td><td>136075</td><td>0</td><td>587</td><td>73566</td><td>0</td><td>582</td></tr><tr><td>05004</td><td>3</td><td>307</td><td>-</td><td>-</td><td>-</td><td>73546</td><td>0</td><td>432</td></tr><tr><td>08190</td><td>1</td><td>556</td><td>135399</td><td>0</td><td>585</td><td>78678</td><td>0</td><td>611</td></tr><tr><td>06900</td><td>5</td><td>479</td><td>135764</td><td>3</td><td>627</td><td>79884</td><td>4</td><td>644</td></tr><tr><td>02623</td><td>2</td><td>681</td><td>144093</td><td>2</td><td>719</td><td>77495</td><td>2</td><td>636</td></tr><tr><td>02624</td><td>2</td><td>350</td><td>144091</td><td>11</td><td>806</td><td>77493</td><td>3</td><td>360</td></tr><tr><td>11522</td><td>1</td><td>446</td><td>141367</td><td>0</td><td>531</td><td>74839</td><td>0</td><td>525</td></tr></table>
415beb43c8b6f6a3169c45a528bb6697fa9845e60c054d472c8c43d4452ac7b4.png
simple
<table><tr><td></td><td>Mantel <i>r</i></td><td>Mantel <i>P</i></td><td><i>K</i>* <i>P</i></td><td>Maddison and Slatkin <i>P</i></td><td>Data type</td><td>Trait group</td></tr><tr><td>All traits</td><td>0.63</td><td>0.001</td><td>&#8211;</td><td>&#8211;</td><td>Multiple traits</td><td>Group of traits</td></tr><tr><td><i>&#945;</i> niche traits</td><td>0.38</td><td>0.001</td><td>&#8211;</td><td>&#8211;</td><td>Multiple traits</td><td>Group of traits</td></tr><tr><td><i>&#946;</i> niche traits</td><td>0.17</td><td>0.005</td><td>&#8211;</td><td>&#8211;</td><td>Multiple traits</td><td>Group of traits</td></tr><tr><td>Voltinism</td><td>0.25</td><td>0.001</td><td>0.001</td><td>&#8211;</td><td>Ordinal</td><td>Life cycle</td></tr><tr><td>Adult life span</td><td>0.40</td><td>0.001</td><td>&#8211;</td><td>0.001</td><td>Nominal</td><td>Life cycle</td></tr><tr><td>Exoskeleton</td><td>0.27</td><td>0.001</td><td>&#8211;</td><td>0.001</td><td>Nominal</td><td>Morphology/physiology</td></tr><tr><td>Body shape</td><td>0.26</td><td>0.001</td><td>&#8211;</td><td>0.001</td><td>Nominal</td><td>Morphology/physiology</td></tr><tr><td>Respiration</td><td>0.09</td><td>0.060</td><td>&#8211;</td><td>0.001</td><td>Nominal</td><td>Morphology/physiology</td></tr><tr><td>BMWP</td><td>0.14</td><td>0.001</td><td>0.001</td><td>&#8211;</td><td>Quantitative</td><td>Morphology/physiology</td></tr><tr><td>Body size</td><td>0.27</td><td>0.001</td><td>0.001</td><td>&#8211;</td><td>Ordinal</td><td>Morphology/physiology</td></tr><tr><td>Flight capacity</td><td>0.21</td><td>0.001</td><td>0.001</td><td>&#8211;</td><td>Ordinal</td><td>Morphology/physiology</td></tr><tr><td>Shelter</td><td>0.05</td><td>0.110</td><td>&#8211;</td><td>0.001</td><td>Nominal</td><td>Behavioral</td></tr><tr><td>Reophily</td><td>0.09</td><td>0.034</td><td>&#8211;</td><td>0.199</td><td>Nominal</td><td>Behavioral</td></tr><tr><td>Micro habitat</td><td>0.27</td><td>0.001</td><td>&#8211;</td><td>0.001</td><td>Nominal</td><td>Behavioral</td></tr><tr><td>Trophic position</td><td>0.20</td><td>0.001</td><td>&#8211;</td><td>0.001</td><td>Nominal</td><td>Behavioral</td></tr></table>
22d3a4ece7bd9eb57aa91935627df1e58b74f6bf8f23d6d4d492f659746ae3d3.png
complex
<table><tr><td rowspan="2">Number of collected ovaries</td><td rowspan="2">Number of cultured COCs</td><td rowspan="2">Number of mature oocytes</td><td colspan="2">Number of Cas9/sgRNA injection oocytes</td><td colspan="2">Cleavage rate at 48 hr post activation</td><td colspan="2">Blastocyst development rate at 144 hr post activation</td></tr><tr><td>Injected group</td><td>Untreated group</td><td>Injected group</td><td>Untreated group</td><td>Injected group</td><td>Untreated group</td></tr><tr><td>400</td><td>810</td><td>420</td><td>195</td><td>225</td><td>52.8% (103/195)<sup>a</sup></td><td>40.4% (91/225)<sup>b</sup></td><td>14.4% (28/195)<sup>a</sup></td><td>13.3% (30/225)<sup>a</sup></td></tr></table>
92328e79b10e4b8ee02b3d31b7473f2c39ccca9e0c9528cd8971ca724e2cb274.png
complex
<table><tr><td>Type of toxicity</td><td colspan="5">&gt;60 and &lt;65 years (n = 100)</td><td colspan="5">&#8805; 65 years (n = 80)</td><td><i>P</i>*</td></tr><tr><td></td><td>0</td><td>1</td><td>2</td><td>3</td><td>4</td><td>0</td><td>1</td><td>2</td><td>3</td><td>4</td><td></td></tr><tr><td>Anemia</td><td>81</td><td>10</td><td>8</td><td>0</td><td>1</td><td>86</td><td>6</td><td>4</td><td>4</td><td>0</td><td><i>0.39</i></td></tr><tr><td>Leukopenia</td><td>54</td><td>15</td><td>19</td><td>7</td><td>5</td><td>45</td><td>11</td><td>26</td><td>11</td><td>6</td><td><i>0.13</i></td></tr><tr><td>Neutropenia</td><td>73</td><td>10</td><td>8</td><td>5</td><td>4</td><td>68</td><td>9</td><td>7</td><td>10</td><td>6</td><td><i>0.32</i></td></tr><tr><td>Febrile Neutropenia</td><td>100</td><td>-</td><td>-</td><td>0</td><td>0</td><td>96</td><td>-</td><td>-</td><td>4</td><td>0</td><td><i>0.05</i></td></tr><tr><td>Infection</td><td>97</td><td>0</td><td>1</td><td>2</td><td>0</td><td>95</td><td>0</td><td>2.5</td><td>2.5</td><td>0</td><td><i>0.50</i></td></tr><tr><td>Fever</td><td>98</td><td>0</td><td>2</td><td>0</td><td>0</td><td>98</td><td>2</td><td>0</td><td>0</td><td>0</td><td><i>0.83</i></td></tr><tr><td>Thrombocytopenia</td><td>90</td><td>7</td><td>2</td><td>0</td><td>1</td><td>91</td><td>4</td><td>1</td><td>3</td><td>1</td><td><i>0.83</i></td></tr><tr><td>Bleeding</td><td>98</td><td>1</td><td>0</td><td>1</td><td>0</td><td>100</td><td>0</td><td>0</td><td>0</td><td>0</td><td><i>0.21</i></td></tr><tr><td>Nausea</td><td>81</td><td>8</td><td>6</td><td>5</td><td>0</td><td>69</td><td>11</td><td>12</td><td>8</td><td>0</td><td><i>0.06</i></td></tr><tr><td>Vomiting</td><td>71</td><td>5</td><td>11</td><td>13</td><td>0</td><td>69</td><td>9</td><td>16</td><td>6</td><td>0</td><td><i>0.98</i></td></tr><tr><td>Mucositis</td><td>84</td><td>5</td><td>8</td><td>3</td><td>0</td><td>92</td><td>1</td><td>5</td><td>1</td><td>0</td><td><i>0.09</i></td></tr><tr><td>Skin</td><td>99</td><td>1</td><td>0</td><td>0</td><td>0</td><td>98</td><td>0</td><td>2</td><td>0</td><td>0</td><td><i>0.43</i></td></tr><tr><td>Diarrhea</td><td>96</td><td>1</td><td>0</td><td>3</td><td>0</td><td>96</td><td>3</td><td>1</td><td>0</td><td>0</td><td><i>0.91</i></td></tr><tr><td>Constipation</td><td>99</td><td>0</td><td>0</td><td>1</td><td>0</td><td>98</td><td>1</td><td>1</td><td>0</td><td>0</td><td><i>0.45</i></td></tr><tr><td>Hepatic</td><td>88</td><td>3</td><td>7</td><td>2</td><td>0</td><td>90</td><td>6</td><td>4</td><td>0</td><td>0</td><td><i>0.60</i></td></tr><tr><td>Cardiac</td><td>100</td><td>0</td><td>0</td><td>0</td><td>0</td><td>96</td><td>0</td><td>2.5</td><td>1</td><td>0</td><td><i>0.09</i></td></tr><tr><td>Fatigue</td><td>96</td><td>1</td><td>3</td><td>0</td><td>0</td><td>95</td><td>0</td><td>2.5</td><td>2.5</td><td>0</td><td><i>0.72</i></td></tr><tr><td>Pulmonary</td><td>100</td><td>0</td><td>0</td><td>0</td><td>0</td><td>99</td><td>1</td><td>0</td><td>0</td><td>0</td><td><i>0.27</i></td></tr><tr><td>Abdominal pain</td><td>99</td><td>0</td><td>0</td><td>1</td><td>0</td><td>99</td><td>0</td><td>0</td><td>1</td><td>0</td><td><i>0.88</i></td></tr><tr><td>Chest pain</td><td>99</td><td>0</td><td>0</td><td>1</td><td>0</td><td>100</td><td>0</td><td>0</td><td>0</td><td>0</td><td><i>0.37</i></td></tr><tr><td>Heartburn</td><td>99</td><td>0</td><td>1</td><td>0</td><td>0</td><td>98</td><td>0</td><td>2</td><td>0</td><td>0</td><td><i>0.44</i></td></tr><tr><td>Headache</td><td>99</td><td>0</td><td>0</td><td>1</td><td>0</td><td>100</td><td>0</td><td>0</td><td>0</td><td>0</td><td><i>0.38</i></td></tr><tr><td>Confusion</td><td>99</td><td>1</td><td>0</td><td>0</td><td>0</td><td>100</td><td>0</td><td>0</td><td>0</td><td>0</td><td><i>0.38</i></td></tr><tr><td>Depression</td><td>100</td><td>0</td><td>0</td><td>0</td><td>0</td><td>99</td><td>0</td><td>0</td><td>1</td><td>0</td><td><i>0.27</i></td></tr><tr><td>Thrombophlebitis</td><td>97</td><td>0</td><td>0</td><td>3</td><td>0</td><td>94</td><td>0</td><td>0</td><td>6</td><td>0</td><td><i>0.30</i></td></tr><tr><td>Dysuria</td><td>99</td><td>0</td><td>0</td><td>1</td><td>0</td><td>99</td><td>0</td><td>0</td><td>1</td><td>0</td><td><i>0.88</i></td></tr><tr><td>Allergy</td><td>99</td><td>0</td><td>0</td><td>1</td><td>0</td><td>100</td><td>0</td><td>0</td><td>0</td><td>0</td><td><i>0.37</i></td></tr><tr><td>Weight gain</td><td>100</td><td>0</td><td>0</td><td>0</td><td>0</td><td>99</td><td>0</td><td>1</td><td>0</td><td>0</td><td><i>0.27</i></td></tr><tr><td>Weight loss</td><td>99</td><td>0</td><td>1</td><td>0</td><td>0</td><td>99</td><td>1</td><td>0</td><td>0</td><td>0</td><td><i>0.89</i></td></tr></table>
300e3de7d4835529a378a9e4fe88a6480dc28144663996b51c07d48a0d06d6fc.png
simple
<table><tr><td>ID </td><td>ALBIA (&gt;20) </td><td>CIA (&gt;10,000) </td><td>ELISA (&gt;20) </td><td>Gender </td><td>Age </td><td>Statin </td><td>ADO (ys) </td><td>CK* (25&#8211;160 U/L) </td><td>Necrosis </td></tr><tr><td>3 </td><td>928 </td><td>201891 </td><td>149.2 </td><td>F</td><td>62 </td><td>+ </td><td>59 </td><td>1000 </td><td>+</td></tr><tr><td>5 </td><td>496 </td><td>213681 </td><td>113.5 </td><td>F</td><td>53 </td><td>&#8722;</td><td>52 </td><td>13777 </td><td>+ </td></tr><tr><td>6 </td><td>960 </td><td>259814 </td><td>193.1 </td><td>M</td><td>59 </td><td>&#8722;</td><td>47 </td><td>8500 </td><td>+</td></tr><tr><td>9 </td><td>1008 </td><td>291111 </td><td>184.9 </td><td>F</td><td>22 </td><td>&#8722;</td><td>18 </td><td>ND </td><td>+ </td></tr><tr><td>10 </td><td>784 </td><td>138696 </td><td>284.3 </td><td>F</td><td>16 </td><td>&#8722;</td><td>13 </td><td>1500 </td><td>+ </td></tr><tr><td>11 </td><td>512 </td><td>244281 </td><td>381.8 </td><td>F </td><td>66 </td><td>+ </td><td>60 </td><td>6500 </td><td>+ </td></tr><tr><td>13 </td><td>768 </td><td>179810 </td><td>153.5 </td><td>F </td><td>69 </td><td>+ </td><td>63 </td><td>492 </td><td>Very few fiber </td></tr><tr><td>15 </td><td>320 </td><td>184190 </td><td>174.7 </td><td>F </td><td>44 </td><td>&#8722;</td><td>21 </td><td>ND </td><td>+ </td></tr><tr><td>17 </td><td>800 </td><td>254442 </td><td>139.4 </td><td>F </td><td>60 </td><td>&#8722;</td><td>54 </td><td>6000 </td><td>+ </td></tr><tr><td>18 </td><td>1136 </td><td>218777 </td><td>126.3 </td><td>F </td><td>53 </td><td>+ </td><td>48 </td><td>4106 </td><td>+ </td></tr><tr><td>26 </td><td>280 </td><td>119734 </td><td>57.9 </td><td>M </td><td>67 </td><td>+ </td><td>66 </td><td>5700 </td><td>+ </td></tr><tr><td>27 </td><td>576 </td><td>180528 </td><td>88.9 </td><td>F </td><td>17 </td><td>&#8722;</td><td>12 </td><td>17000 </td><td>+ </td></tr><tr><td>28 </td><td>528 </td><td>288198 </td><td>93.8 </td><td>M </td><td>65 </td><td>&#8722;</td><td>52 </td><td>500 </td><td>+ </td></tr><tr><td>29 </td><td>84 </td><td>79904 </td><td>29.8 </td><td>F </td><td>75 </td><td>+ </td><td>73 </td><td>7429 </td><td>No biopsy </td></tr><tr><td>30 </td><td>196 </td><td>135149 </td><td>49.7 </td><td>F </td><td>72 </td><td>+ </td><td>68 </td><td>3700 </td><td>+ </td></tr><tr><td>31 </td><td>608 </td><td>250484 </td><td>324.1 </td><td>F </td><td>35 </td><td>&#8722; </td><td>26 </td><td>5700 </td><td>+ </td></tr><tr><td>32 </td><td>424 </td><td>141861 </td><td>932.1 </td><td>M </td><td>81 </td><td>&#8722; </td><td>82 </td><td>ND </td><td>+ </td></tr><tr><td>34 </td><td>400 </td><td>208075 </td><td>118.5 </td><td>F </td><td>84 </td><td>+ </td><td>83 </td><td>4119 </td><td>ND </td></tr><tr><td>37 </td><td>212 </td><td>160034 </td><td>83.3 </td><td>F </td><td>20 </td><td>&#8722; </td><td>15 </td><td>612 </td><td>+ </td></tr><tr><td>39 </td><td>142 </td><td>115671 </td><td>56.6 </td><td>F </td><td>67 </td><td>+ </td><td>58 </td><td>2000 </td><td>&#8722; </td></tr></table>
e4d1b386b7311b0209dd4fca6c7dbfea7a1b7c980e986ccdd5fd53b78f36e6b9.png
complex
<table><tr><td>Characteristics</td><td colspan="2">2000</td><td colspan="2">2004</td><td colspan="2">2007</td></tr><tr><td></td><td>No ICH n = 34282</td><td>ICH n = 230</td><td>No ICH n = 47555</td><td>ICH n = 289</td><td>No ICH n = 56921</td><td>ICH n = 340</td></tr><tr><td colspan="7">No. (%)</td></tr><tr><td>Age (mean &#177; SD), y</td><td>57.3 &#177; 14.5</td><td>58.9 &#177; 12</td><td>59.1 &#177; 14.1</td><td>58.6 &#177; 12.5</td><td>60.7 &#177; 13.9</td><td>60.7 &#177; 11.9</td></tr><tr><td>Female</td><td>18303 (53.4)</td><td>107 (46.5)</td><td>25598 (53.8)</td><td>120 (41.5)</td><td>30186 (53.0)</td><td>155 (45.6)</td></tr><tr><td colspan="7">Dialysis modality</td></tr><tr><td> Hemodialysis</td><td>32340 (94.3)</td><td>224 (97.4)</td><td>44408 (93.4)</td><td>279 (96.5)</td><td>52569 (92.4)</td><td>320 (94.1)</td></tr><tr><td> Peritoneal dialysis</td><td>1942 (5.7)</td><td>6 (2.6)</td><td>2147 (6.6)</td><td>10 (3.5)</td><td>4352 (7.6)</td><td>20 (5.9)</td></tr><tr><td> ICH in-hospital days</td><td></td><td>11.2 (&#177;15.9)</td><td></td><td>10.9 (&#177;11.3)</td><td></td><td>13.2 (&#177;15.2)</td></tr><tr><td colspan="7">Comorbid conditions</td></tr><tr><td> Hypertension</td><td>17192 (50.1)</td><td>143 (62.2)</td><td>25044 (52.7)</td><td>170 (58.8)</td><td>33072 (58.1)</td><td>238 (70.0)</td></tr><tr><td> Diabetes</td><td>11356 (33.1)</td><td>101 (43.9)</td><td>15897 (33.4)</td><td>118 (40.8)</td><td>21559 (37.9)</td><td>166 (48.8)</td></tr><tr><td> Chronic liver disease</td><td>7528 (21.9)</td><td>26 (11.3)</td><td>11902 (25.0)</td><td>59 (20.4)</td><td>14203 (24.9)</td><td>91 (26.8)</td></tr><tr><td> Coronary artery disease</td><td>6252 (18.3)</td><td>48 (20.9)</td><td>9290 (19.6)</td><td>67 (23.2)</td><td>12355 (21.7)</td><td>88 (25.9)</td></tr><tr><td> Heart failure</td><td>3795 (11.1)</td><td>33 (14.3)</td><td>5734 (12.1)</td><td>34 (11.8)</td><td>7300 (12.8)</td><td>46 (13.5)</td></tr><tr><td> Prior stroke</td><td>3153 (9.3)</td><td>44 (19.1)</td><td>4633 (9.8)</td><td>63 (21.8)</td><td>5815 (10.3)</td><td>91 (26.8)</td></tr><tr><td> Chronic lung disease</td><td>3021 (8.8)</td><td>19 (8.3)</td><td>3878 (8.2)</td><td>24 (8.3)</td><td>4209 (7.4)</td><td>21 (6.2)</td></tr><tr><td> Peripheral artery disease</td><td>1858 (5.4)</td><td>11 (4.8)</td><td>1621 (3.4)</td><td>9 (3.1)</td><td>2803 (4.9)</td><td>27 (8.7)</td></tr><tr><td> Cancer</td><td>1116 (3.2)</td><td>2 (0.9)</td><td>2752 (5.8)</td><td>13 (4.5)</td><td>4150 (7.3)</td><td>21 (6.2)</td></tr></table>
511e8eb40a49a95a9ac7769b89957e2c655ab1ced32f8274eea4261668e177d8.png
complex
<table><tr><td> </td><td>Total sample (#78)</td><td>Exposed to DMD (#45)</td><td>Not-exposed (#33)</td><td>p</td></tr><tr><td colspan="5"><i>Variables related to MS father</i></td></tr><tr><td>Age, mean (SD) years (#78)</td><td>34.8 (4.8)</td><td>35.4 (5.3)</td><td>33.9 (3.9)</td><td>0.476*</td></tr><tr><td>Education, mean (SD) years (#62)</td><td>13.4 (3.5)</td><td>13.2 (3.3)</td><td>13.8 (4.0)</td><td>0.548*</td></tr><tr><td>Age at onset, mean (SD) years (#75)</td><td>26.5(6.8)</td><td>27.0 (7.2)</td><td>25.7 (6.2)</td><td>0.352*</td></tr><tr><td>Disease duration, mean (SD) years (#74)</td><td>8.4 (5.9)</td><td>8.5 (6.0)</td><td>8.3 (5.9)</td><td>0.812*</td></tr><tr><td>Smokers # (%) (#78)</td><td>26 (33.3)</td><td>14 (31.1)</td><td>12 (36.4)</td><td>0.627**</td></tr><tr><td>Alcohol # (%) (#78)</td><td>14 (17.9)</td><td>10 (22.2)</td><td>4 (12.1)</td><td>0.251**</td></tr><tr><td colspan="5"><i>Variables related to pregnancy and fetal outcomes</i></td></tr><tr><td>Drug and toxin exposure # (%) (78)</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Smoking exposure # (%) (78)</td><td>5 (6.4)</td><td>2 (4.4)</td><td>3 (9.1)</td><td>0.645&#167;</td></tr><tr><td>Alcohol exposure # (%) (#78)</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Gestational age (weeks) (#72)</td><td>38.9 (3.8)</td><td>39.0 (2.1)</td><td>38.7 (5.2)</td><td>0.513*</td></tr><tr><td>Preterm delivery # (%) (#72)</td><td>10 (13.9)</td><td>7 (17.1)</td><td>3 (9.7)</td><td>0.499&#167;</td></tr><tr><td>Caesarean delivery # (%) (#75)</td><td>24 (32.0)</td><td>15 (34.1)</td><td>9 (29.0)</td><td>0.644**</td></tr><tr><td>Epidural analgesia # (%) (#75)</td><td>16 (21.3)</td><td>10 (22.7)</td><td>6 (19.4)</td><td>0.726**</td></tr><tr><td>Gender of the baby male/female (#75)</td><td>36/39</td><td>21/23</td><td>15/16</td><td>0.955**</td></tr><tr><td>Birth-weight mean (SD) gr (#75)</td><td>3301.3 (454.9)</td><td>3282.3 (445.5)</td><td>3328.4 (474.1)</td><td>0.821*</td></tr><tr><td>Birth-length mean (SD) cm (#67)</td><td>50.1 (2.2)</td><td>49.9 (2.3)</td><td>50.2 (2.1)</td><td>0.649*</td></tr></table>
60d8fdf546d8b2955c16608d66697ab47245782e9605c911be85b2e323659510.png
complex
<table><tr><td rowspan="2">Type of abuse</td><td colspan="2">Abusive incidents (<i>n</i>=209)*</td></tr><tr><td><i>N</i></td><td>%</td></tr><tr><td>Minor incidents</td><td>208</td><td>99.9%</td></tr><tr><td>Major incidents</td><td>55</td><td>26.0%</td></tr><tr><td>Severe incidents</td><td>17</td><td>8.0%</td></tr></table>
e87fe3a01029f41eadf05bc866ba1ece1e93f34bac629b61c3c2adac4aeb22a0.png
complex
<table><tr><td> Trial</td><td>Regiments</td><td><i>N</i></td><td>CR</td><td>OR</td><td>OS (months)</td><td>Median PFS (months)</td></tr><tr><td rowspan="2">Robak et al. [25]</td><td>RC</td><td>18</td><td>13%</td><td>67%</td><td>ND</td><td>12</td></tr><tr><td>versus RCC</td><td>28</td><td>9%</td><td>78%</td><td>ND</td><td>12</td></tr><tr><td rowspan="2">Robak et al. [26]</td><td>FC</td><td>276</td><td>13%</td><td>58%</td><td>46</td><td>20.6</td></tr><tr><td>versus RFC</td><td>276</td><td>24.3%</td><td>69.6%</td><td>64</td><td>30.6</td></tr><tr><td> Castro et al. [27]</td><td>Rituximab HDMP</td><td>14</td><td>36%</td><td>93%</td><td>ND</td><td>ND</td></tr><tr><td rowspan="2">Wierda [28]</td><td>Ofatumumab, FA-ref,</td><td>95</td><td>0%</td><td>51%</td><td>14.2</td><td>5.5</td></tr><tr><td>versus ofatumumab, BF-ref</td><td>111</td><td>2%</td><td>54%</td><td>17.4</td><td>5.5</td></tr><tr><td> Gritti et al. [29]</td><td>Alemtuzumab</td><td>18</td><td>8%</td><td>44%</td><td>ND</td><td>14.6</td></tr><tr><td> Zent et al. [30]</td><td>PAR</td><td>19</td><td>32%</td><td>74%</td><td>23</td><td>7</td></tr><tr><td> Badoux et al. [31]</td><td>CFAR</td><td>31</td><td>29%</td><td>65%</td><td>11</td><td>7</td></tr><tr><td rowspan="2">O'Brien et al. [32]</td><td>FC</td><td>120</td><td>9%</td><td>17%</td><td>34</td><td>6</td></tr><tr><td>versus FC-oblimersen</td><td>121</td><td>3%</td><td>7%</td><td>33</td><td>9</td></tr><tr><td> Chen et al. [33]</td><td>Lenalidomide</td><td>25</td><td>0%</td><td>56%</td><td>24</td><td>24</td></tr></table>
c22a3a6d8bc32bc25756587ca7f586d324f00f3a72d3e55656f82a9f2433efd1.png
complex
<table><tr><td rowspan="2">AFB1 Spiked Level (&#956;g/kg)</td><td colspan="6">AFB1 Recovery * (&#956;g/kg)</td><td rowspan="2">R (%)</td></tr><tr><td>Assay 1</td><td>Assay 2</td><td>Assay 3</td><td>Assay 4</td><td>Assay 5</td><td>Mean &#177; SD</td></tr><tr><td>5.0</td><td>4.67</td><td>4.64</td><td>4.34</td><td>4.54</td><td>4.49</td><td>4.54 &#177; 0.13</td><td>90.20</td></tr><tr><td>10.0</td><td>9.23</td><td>9.54</td><td>9.17</td><td>9.34</td><td>9.29</td><td>9.31 &#177; 0.14</td><td>93.14</td></tr></table>
dd9d343490c1973eb591d4e867b4dc65c8ce6c287fec988b9a07f97ea009f150.png
complex
<table><tr><td>Parameters</td><td>Responders (<i>n</i> = 25)</td><td>Non-responders (<i>n</i> = 5)</td><td><i>p</i> value</td></tr><tr><td colspan="4">Age at treatment</td></tr><tr><td> &#8804; 62 vs &gt; 62</td><td>12 (48.0%) vs 13 (52.0%)</td><td>3 (60.0%)/2 (40.0%)</td><td>0.638</td></tr><tr><td colspan="4">Degree of progress</td></tr><tr><td> Locally advanced vs visceral metastases</td><td>9 (36.0%)/16 (64.0%)</td><td>1 (20.0%)/4 (80.0%)</td><td>0.505</td></tr><tr><td colspan="4">Stage</td></tr><tr><td> IIIC or IV vs recurrence</td><td>12 (48.8%)/13 (52.0%)</td><td>3 (60.0%)/2 (40.0%)</td><td>0.638</td></tr><tr><td colspan="4">ER</td></tr><tr><td> Negative vs positive</td><td>16 (64.0%)/9 (36.0%)</td><td>2 (40.0%)/3 (60.0%)</td><td>0.334</td></tr><tr><td colspan="4">PgR</td></tr><tr><td> Negative vs positive</td><td>17 (68.0%)/8 (32.0%)</td><td>3 (60.0%)/2 (40.0%)</td><td>0.740</td></tr><tr><td colspan="4">Ki67</td></tr><tr><td> Negative vs positive</td><td>14 (56.0%)/11 (44.4%)</td><td>2 (40.0%)/3 (60.0%)</td><td>0.529</td></tr><tr><td colspan="4">Treatment line</td></tr><tr><td> First vs other</td><td>16 (64.0%)/9 (36.0%)</td><td>1 (20.0%)/4 (80.0%)</td><td>0.074</td></tr><tr><td colspan="4">CD8</td></tr><tr><td> Negative vs positive</td><td>16 (64.0%)/9 (36.0%)</td><td>5 (100.0%)/0 (0.0%)</td><td>0.116</td></tr><tr><td colspan="4">FOXP3</td></tr><tr><td> Negative vs positive</td><td>12 (48.8%)/13 (52.0%)</td><td>3 (60.0%)/2 (40.0%)</td><td>0.638</td></tr><tr><td colspan="4">CFR</td></tr><tr><td> Low/high</td><td>10 (40.0%)/15 (60.0%)</td><td>5 (100.0%)/0 (0.0%)</td><td>0.013</td></tr><tr><td colspan="4">PD1</td></tr><tr><td> Negative vs positive</td><td>11 (44.0%)/14 (56.0%)</td><td>3 (60.0%)/2 (40.0%)</td><td>0.529</td></tr><tr><td colspan="4">PD-L1</td></tr><tr><td> Negative vs positive</td><td>17 (68.0%)/8 (32.0%)</td><td>2 (40.0%)/3 (60.0%)</td><td>0.250</td></tr><tr><td colspan="4">CD163</td></tr><tr><td> Negative vs positive</td><td>12 (48.8%)/13 (52.0%)</td><td>3 (60.0%)/2 (40.0%)</td><td>0.638</td></tr><tr><td colspan="4">PTEN</td></tr><tr><td> Negative vs positive</td><td>13 (52.0%)/12 (48.8%)</td><td>4 (80.0%)/1 (20.0%)</td><td>0.264</td></tr><tr><td colspan="4">LAG3</td></tr><tr><td> Negative vs positive</td><td>16 (64.0%)/9 (36.0%)</td><td>4 (80.0%)/1 (20.0%)</td><td>0.505</td></tr></table>
8bcbcd38fbc84719c479855bcecc73dd1115092f75c4e9dd051832cf13e4fba7.png
simple
<table><tr><td>Species</td><td>Suckling Duration (s)</td><td>Reference </td></tr><tr><td>Southern right whales</td><td>90&#8211;210</td><td>Thomas &amp; Taber 1984 [35]</td></tr><tr><td>Bowhead whale</td><td>&lt;60 </td><td>Wursig et al., 1984 [36]</td></tr><tr><td>Gray whale</td><td>20&#8211;76 </td><td>Smultea et al., 2017 [34]</td></tr><tr><td>Blue whale</td><td>13&#8211;264 </td><td>Smultea et al., 2017 [34]</td></tr><tr><td>Fin whale</td><td>30&#8211;138 </td><td>Smultea et al., 2017 [34]</td></tr></table>
03e67ef146fa544caddc2bc2b1bde5fdd7b7f67f2a678779b5060b69057fbe86.png
complex
<table><tr><td>Respondent nr.</td><td colspan="3">Deceased patient</td><td colspan="5">Family caregiver (Respondent)</td></tr><tr><td></td><td>Sex</td><td>Age</td><td>Diagnosis</td><td>Relation to patient</td><td>Sex</td><td>Age</td><td>Terminal leave</td><td>Occupation status</td></tr><tr><td>1</td><td>Male</td><td>72</td><td>Lung cancer</td><td>Spouse</td><td>Female</td><td>63</td><td>No</td><td>On pension</td></tr><tr><td>2</td><td>Male</td><td>72</td><td>Lung cancer</td><td>Spouse</td><td>Female</td><td>70</td><td>No</td><td>On pension</td></tr><tr><td>3</td><td>Male</td><td>63</td><td>Primary tumour unknown</td><td>Spouse</td><td>Female</td><td>55</td><td>Yes</td><td>Active work</td></tr><tr><td>4</td><td>Female</td><td>56</td><td>Pancoast tumour (lung cancer)</td><td>Spouse</td><td>Male</td><td>59</td><td>No</td><td>Unemployed</td></tr><tr><td>5</td><td>Female</td><td>63</td><td>Lung cancer</td><td>Spouse</td><td>Male</td><td>69</td><td>No</td><td>On pension</td></tr><tr><td>6</td><td>Male</td><td>57</td><td>Lung cancer</td><td>Spouse</td><td>Female</td><td>56</td><td>Yes</td><td>Active work</td></tr><tr><td>7</td><td>Female</td><td>53</td><td>Breast cancer</td><td>Spouse</td><td>Male</td><td>56</td><td>Yes</td><td>Active work</td></tr></table>
7fad9e2a19dd4dba550590db7005ad83e56bf544a7b54b33e546877cab236481.png
complex
<table><tr><td>Characteristic</td><td colspan="2"><i>n</i> (%)<i>a</i></td></tr><tr><td>Maternal age (years)</td><td></td><td></td></tr><tr><td>&lt; 27</td><td>13,614</td><td>(20.6)</td></tr><tr><td>27&#8211;29</td><td>17,880</td><td>(27.0)</td></tr><tr><td>30&#8211;32</td><td>16,517</td><td>(25.0)</td></tr><tr><td>&gt; 32</td><td>18,192</td><td>(27.5)</td></tr><tr><td>Parity</td><td></td><td></td></tr><tr><td>Primiparous</td><td>29,574</td><td>(44.7)</td></tr><tr><td>Multiparous</td><td>34,240</td><td>(51.7)</td></tr><tr><td>Unknown</td><td>2,389</td><td>(3.6)</td></tr><tr><td>General maternal health</td><td></td><td></td></tr><tr><td>Very good</td><td>33,454</td><td>(50.5)</td></tr><tr><td>Average</td><td>28,114</td><td>(42.5)</td></tr><tr><td>Bad</td><td>2,263</td><td>(3.4)</td></tr><tr><td>Unknown</td><td>2,372</td><td>(3.6)</td></tr><tr><td>Socioeconomic status</td><td></td><td></td></tr><tr><td>High</td><td>32,627</td><td>(49.3)</td></tr><tr><td>Medium</td><td>23,299</td><td>(35.2)</td></tr><tr><td>Low</td><td>5,220</td><td>(7.9)</td></tr><tr><td>Unknown</td><td>5,057</td><td>(7.6)</td></tr><tr><td>Infant sex</td><td></td><td></td></tr><tr><td>Male</td><td>33,779</td><td>(51.0)</td></tr><tr><td>Female</td><td>32,424</td><td>(49.0)</td></tr><tr><td>Hypertension during pregnancy</td><td></td><td></td></tr><tr><td>Yes</td><td>8,824</td><td>(13.3)</td></tr><tr><td>No</td><td>57,192</td><td>(86.4)</td></tr><tr><td>Unknown</td><td>187</td><td>(0.3)</td></tr><tr><td>Gestational diabetes</td><td></td><td></td></tr><tr><td>Yes</td><td>1,632</td><td>(2.5)</td></tr><tr><td>No</td><td>64,225</td><td>(97.0)</td></tr><tr><td>Unknown</td><td>346</td><td>(0.5)</td></tr><tr><td>Smoking</td><td></td><td></td></tr><tr><td>Yes</td><td>17,020</td><td>(25.7)</td></tr><tr><td>No</td><td>47,255</td><td>(71.4)</td></tr><tr><td>Unknown</td><td>1,928</td><td>(2.9)</td></tr><tr><td colspan="3">Maternal life stress during pregnancy<i>b</i> (score)</td></tr><tr><td>Low (0)</td><td>19,793</td><td>(29.9)</td></tr><tr><td>Low-medium (&gt; 0 to &#8804; 1)</td><td>14,488</td><td>(21.9)</td></tr><tr><td>Medium-high (&gt; 1 to &#8804; 3)</td><td>20,377</td><td>(30.8)</td></tr><tr><td>High (&gt; 3)</td><td>11,545</td><td>(17.4)</td></tr><tr><td colspan="3">Maternal emotional stress during pregnancy<i>b</i> (score)</td></tr><tr><td>Low (&#8804; 1)</td><td>25,083</td><td>(37.9)</td></tr><tr><td>Low-medium (&gt; 1 to &#8804; 2)</td><td>11,432</td><td>(17.3)</td></tr><tr><td>Medium-high (&gt; 2 to &#8804; 4)</td><td>15,971</td><td>(24.1)</td></tr><tr><td>High (&gt; 4)</td><td>13,717</td><td>(20.7)</td></tr><tr><td colspan="3">Maternal life stress after pregnancy<i>b</i> (score)</td></tr><tr><td>Low (0)</td><td>32,296</td><td>(48.8)</td></tr><tr><td>Low-medium (&gt; 0 to &#8804; 1)</td><td>13,829</td><td>(20.9)</td></tr><tr><td>Medium-high (&gt; 1 to &#8804; 2)</td><td>9,725</td><td>(14.7)</td></tr><tr><td>High (&gt; 2)</td><td>10,353</td><td>(15.6)</td></tr><tr><td colspan="3">Maternal emotional stress after pregnancy<i>b</i> (score)</td></tr><tr><td>Low (0)</td><td>22,313</td><td>(33.7)</td></tr><tr><td>Low-medium (&gt; 0 to &#8804; 1)</td><td>12,557</td><td>(19.0)</td></tr><tr><td>Medium-high (&gt; 1 to &#8804; 3)</td><td>15,847</td><td>(23.9)</td></tr><tr><td>High (&gt; 3)</td><td>15,486</td><td>(23.4)</td></tr><tr><td colspan="3">aPercentages may not total 100 because of rounding. bStress groups were defined by the closest possible cutoffs to the quartiles of their distribution.</td></tr></table>
8bf9625e341d76c0f5ee4e3c0bc4b88bc4f211f58f0aa582ed0ee1523e93e0e6.png
complex
<table><tr><td rowspan="2">Model</td><td colspan="3">Aquatic species</td><td colspan="3">Terrestrial species</td></tr><tr><td>AEV</td><td>Pseudo-F</td><td><i>P</i></td><td>AEV</td><td>Pseudo-F</td><td><i>P</i></td></tr><tr><td>Month</td><td>67.3%</td><td>9.9</td><td><i>0.0001</i></td><td>57.1%</td><td>6.3</td><td><i>0.0001</i></td></tr><tr><td>Humidity (<i>H</i>)</td><td>16.0%</td><td>6.0</td><td><i>0.0005</i></td><td>20.7%</td><td>7.3</td><td><i>0.0006</i></td></tr><tr><td>Temperature (<i>T</i>)</td><td>23.1%</td><td>8.8</td><td><i>0.0001</i></td><td>2.0%</td><td>1.5</td><td>0.23</td></tr><tr><td>Wind speed (<i>W</i>)</td><td>7.6%</td><td>3.2</td><td><i>0.012</i></td><td>12.7%</td><td>4.5</td><td><i>0.009</i></td></tr><tr><td>Cloud cover (<i>C</i>)</td><td>3.1%</td><td>1.8</td><td>0.10</td><td>13.4%</td><td>4.7</td><td><i>0.007</i></td></tr><tr><td>Air pressure</td><td>0.9%</td><td>1.2</td><td>0.26</td><td>0.1%</td><td>1.0</td><td>0.38</td></tr><tr><td><i>T</i> + TH regime</td><td>35.8%</td><td>8.3</td><td><i>0.0001</i></td><td>&#8211;</td><td>&#8211;</td><td>&#8211;</td></tr><tr><td><i>T</i> + <i>H</i></td><td>35.7%</td><td>8.2</td><td><i>0.0001</i></td><td>&#8211;</td><td>&#8211;</td><td>&#8211;</td></tr><tr><td><i>H</i> + TH regime</td><td>33.2%</td><td>7.5</td><td><i>0.0001</i></td><td>20.7%</td><td>4.1</td><td><i>0.0002</i></td></tr><tr><td><i>T</i> + <i>H</i> + <i>W</i><sup>a</sup></td><td>38.8%</td><td>6.5</td><td><i>0.0001</i></td><td>&#8211;</td><td>&#8211;</td><td>&#8211;</td></tr><tr><td><i>T</i> + <i>H</i> + <i>W</i> (month)</td><td>0%</td><td>1.0</td><td>0.55</td><td>&#8211;</td><td>&#8211;</td><td>&#8211;</td></tr><tr><td><i>H</i> + <i>W</i> + <i>C</i><sup>b</sup></td><td>&#8211;</td><td>&#8211;</td><td>&#8211;</td><td>37.3%</td><td>5.8</td><td><i>0.0002</i></td></tr><tr><td><i>H</i> + <i>W</i> + <i>C</i> (month)</td><td>&#8211;</td><td>&#8211;</td><td>&#8211;</td><td>18.7%</td><td>2.4</td><td><i>0.038</i></td></tr></table>
281512b3902e648d5aac695057310c4ba833e8b8ccd7859b319bc051a30e486a.png
complex
<table><tr><td> </td><td>Odds ratio</td><td>95% CI</td><td>p<sup>*</sup></td></tr><tr><td colspan="4">Presence of psychotic symptoms</td></tr><tr><td>Switch</td><td>0.34</td><td>0.08 to 1.48</td><td>0.152</td></tr><tr><td>Augmentation</td><td>3.25</td><td>1.02 to 10.31</td><td>0.045</td></tr><tr><td colspan="4">Number of major depressive episodes</td></tr><tr><td>Switch</td><td>0.96</td><td>0.83 to 1.11</td><td>0.558</td></tr><tr><td>Augmentation</td><td>1.23</td><td>1.07 to 1.43</td><td>0.005</td></tr></table>
63528196a5db89327fcaba6e9c3d53b9a738d720691ffa4a445c97b3a836eca6.png
simple
<table><tr><td>Motion</td><td>Reconstructed ankle</td><td>Normal ankle</td></tr><tr><td>Dorsiflexion</td><td>24.2&#176; &#177; 5.84&#176;</td><td>24.7&#176; &#177; 4.85&#176;*</td></tr><tr><td>Plantarflexion</td><td>43.7&#176; &#177; 5.74&#176;</td><td>43.4&#176; &#177; 4.10&#176;*</td></tr></table>
136d5e014ca80bcca5d8a8ade1b3fafa4babbfe6f67aa57e9ab01d0a759ae190.png
simple
<table><tr><td>Target</td><td>Sequences</td></tr><tr><td>IL-18</td><td>Forward 5'-GAAACGTCAATAGCCAGTTGC-3'</td></tr><tr><td></td><td>Reverse 5'-TCCCATGCTCTTTCTCACAACA-3'</td></tr><tr><td>IL-10</td><td>Forward 5'-AGCAGATCAAGGAGACGTTC-3'</td></tr><tr><td></td><td>Reverse 5'-ATCAGCAGGTACTCCTCGAT-3'</td></tr><tr><td>IL-8</td><td>Forward 5&#8217;-TATCACTGGAGAGTCTCGCTGTC-3&#8217;</td></tr><tr><td></td><td>Reverse 5&#8217;-TCAGTCCTCCTGCAGTGTATACC-3&#8217;</td></tr><tr><td>IFN-&#947;</td><td>Forward 5' - ACACTGACAAGTAAAGCCGCACA-3'</td></tr><tr><td></td><td>Reverse 5' -AGTCGTTCATCGGGAGCTTGGC-3'</td></tr><tr><td>&#946;-actin</td><td>Forward 5'-CAACACAGTGCTGTCTGGTGGTA-3'</td></tr><tr><td></td><td>Reverse 5'-ATCGTACTCCTGCTTGCTGATCC-3'</td></tr></table>
dea53afb5c19936d57585b0aa30eae26111ecd639710bf8a3ff52144e85d7457.png
complex
<table><tr><td rowspan="2">Disease Stage</td><td rowspan="2">Gene Symbol</td><td rowspan="2">Accession Number</td><td colspan="4">Fold Change (FC)</td></tr><tr><td colspan="2">HTA 2.0</td><td colspan="2">qRT-PCR</td></tr><tr><td>Normal vs. HCV+</td><td></td><td></td><td>CA</td><td>AA</td><td>CA</td><td>AA</td></tr><tr><td></td><td><i>SAA1</i></td><td>NM_000331</td><td>3.36</td><td>NA</td><td>3.12</td><td>2.0*</td></tr><tr><td></td><td><i>AOX1</i></td><td>NM_001159</td><td>3.45</td><td>NA</td><td>3.10</td><td>3.3</td></tr><tr><td></td><td><i>SLC13A5</i></td><td>NM_001143838</td><td>3.27</td><td>NA</td><td>3.51</td><td>3.0</td></tr><tr><td>HCCN vs. HCV+HCC</td><td><i>PCNA-AS1</i></td><td>NR_028370</td><td>3.53</td><td>NA</td><td>3.2</td><td>0.99*</td></tr><tr><td></td><td><i>ROBO1</i></td><td>NM_001145845</td><td>2.20</td><td>NA</td><td>2.9</td><td>0.20*</td></tr><tr><td></td><td><i>DAB2</i></td><td>NM_001244871</td><td>2.20</td><td>NA</td><td>3.0</td><td>0.55*</td></tr><tr><td></td><td><i>IFI30</i></td><td>NM_001244871</td><td>2.21</td><td>NA</td><td>2.0</td><td>0.72*</td></tr><tr><td></td><td><i>SNORD82</i></td><td>NR_004398</td><td>-2.20</td><td>NA</td><td>-2.0</td><td>-2.0</td></tr></table>
604d14c44f0c44bd1762fe49991869f429a020ec537f1682ec7b9eac30205eac.png
simple
<table><tr><td>Characteristic</td><td>Systemic sclerosis (<i>n</i> = 90)</td><td>Systemic lupus erythematosus (<i>n</i> = 100)</td></tr><tr><td>Female</td><td>78 (86.7%)</td><td>87 (87%)</td></tr><tr><td>Age (years)</td><td>57.7 &#177; 14.4</td><td>48.1 &#177; 15.1</td></tr><tr><td>Disease duration (months)</td><td>85.0 &#177; 96.0</td><td>69.6 &#177; 92.0</td></tr><tr><td>Body mass index</td><td>24.5 &#177; 4.0</td><td>25.2 &#177; 4.7</td></tr><tr><td>Adipositas, body mass index &gt;30</td><td>6 (6.7%)</td><td>14 (14%)</td></tr><tr><td>Hypertension</td><td>45 (50%)</td><td>56 (56%)</td></tr><tr><td> Systolic blood pressure (mmHg)</td><td>129.9 &#177; 23.2</td><td>130.6 &#177; 21.5</td></tr><tr><td> Diastolic blood pressure (mmHg)</td><td>75.9 &#177; 11.5</td><td>77.6 &#177; 10.6</td></tr><tr><td> Mean number of antihypertensives</td><td>0.8 (0, 4)</td><td>0.9 (0, 6)</td></tr><tr><td>Diabetes</td><td>4 (4.4%)</td><td>6 (6%)</td></tr><tr><td>Pulmonary hypertension</td><td>17 (18.9%)</td><td>3 (3%)</td></tr><tr><td>Coronary heart disease</td><td>10 (11.1%)</td><td>9 (9%)</td></tr><tr><td>Peripheral artery vessel disease</td><td>5 (5.6%)</td><td>2 (2%)</td></tr><tr><td>Nicotine use, current or former</td><td>43 (47.8%)</td><td>53 (53%)</td></tr><tr><td> Nicotine pack-years</td><td>10.7 &#177; 19.5</td><td>10.4 &#177; 16.2</td></tr><tr><td>Triglyceride (mg/dl)</td><td>139.2 &#177; 84.9</td><td>128.1 &#177; 69.9</td></tr><tr><td>Cholesterol (mg/dl)</td><td>216.5 &#177; 50.2</td><td>213.9 &#177; 59.6</td></tr><tr><td>Low density lipoprotein (mg/dl)</td><td>125.5 &#177; 39.2</td><td>123.7 &#177; 46.8</td></tr><tr><td>High density lipoprotein (mg/dl)</td><td>63.7 &#177; 18.7</td><td>64.4 &#177; 17.9</td></tr><tr><td>Family history of cardiovascular disease</td><td>12 (13.3%)</td><td>16 (16%)</td></tr><tr><td>Mean Rodnan skin score (median, range)</td><td>11 (9, 43)</td><td>&#8211;</td></tr><tr><td>Mean SLEDAI (median, range)</td><td>&#8211;</td><td>11 (9, 60)</td></tr><tr><td>Mean SLICC (median, range)</td><td>&#8211;</td><td>2 (2, 8)</td></tr></table>
f3d202cffcfcc6d112178fc1b445320eead2d649ecbe31ba389d2ab6d6d05c69.png
simple
<table><tr><td></td><td>Chronological age mean (std.) [min&#8211;max]</td><td>Age at implantation mean (std.) [min&#8211;max]</td><td>Duration of CI experience mean (std.) [min&#8211;max]</td><td>Age at profound hearing loss mean (std.) [min&#8211;max]</td></tr><tr><td>NH adults</td><td>34.8 (11.4) [21.2&#8211;50.9]</td><td></td><td></td><td></td></tr><tr><td>NH children</td><td>11.8 (3.4) [6.1&#8211;18.1]</td><td></td><td></td><td></td></tr><tr><td>CI adults</td><td>57.2 (3.6) [52.5&#8211;61.2]</td><td>49.3 (7.3) [41.0&#8211;59.0]</td><td>7.9 (4.9) [2.2&#8211;13.0]</td><td>20.1 (18.5) [1.5&#8211;49.0]</td></tr><tr><td>CI children</td><td>13.0 (3.0) [8.1&#8211;17.9]</td><td>2.6 (2.3) [1.1&#8211;11.9]</td><td>10.4 (3.5) [4.9&#8211;16.6]</td><td>0.5 (1.1) [0.0&#8211;3.5]</td></tr></table>
3dbe9ed77676c6b431d7ac089220f47f661c65252a534b1446a72e6b479ffba1.png
complex
<table><tr><td rowspan="2"></td><td colspan="2">Duloxetine</td><td colspan="2">Venlafaxine</td><td colspan="2">SSRI</td><td colspan="2">Untreated</td></tr><tr><td>N removed</td><td>N eligible remaining</td><td>N removed</td><td>N eligible remaining</td><td>N removed</td><td>N eligible remaining</td><td>N removed</td><td>N eligible remaining</td></tr><tr><td>Member of commercial health insurance plan, with medical coverage and pharmacy benefits, and presence of qualifying event<sup>a</sup> during the accrual period</td><td></td><td>156,682 (100.0 %)</td><td></td><td>231,793 (100 %)</td><td></td><td>1,314,147 (100 %)</td><td></td><td>1,577,784 (100 %)</td></tr><tr><td>Baseline exclusions</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> Less than 18 years at index date</td><td>1396</td><td>155,286 (99.1 %)</td><td>2482</td><td>229,311 (98.9 %)</td><td>33,476</td><td>1,280,671 (97.5 %)</td><td>60,552</td><td>1,517,232 (96.2 %)</td></tr><tr><td> Less than 12 months prior continuous enrollment</td><td>79,819</td><td>75,467 (48.2 %)</td><td>136,147</td><td>93,164 (40.2 %)</td><td>780,943</td><td>499,728 (38.0 %)</td><td>791,027</td><td>726,205 (46.0 %)</td></tr><tr><td> Prior dispensing of study drug or drug class in the baseline</td><td>0</td><td>75,467 (48.2 %)</td><td>23,753</td><td>69,411 (29.9 %)</td><td>134,294</td><td>365,434 (27.8 %)</td><td>334,496</td><td>391,709 (24.8 %)</td></tr><tr><td> Had no depression diagnosis in the baseline</td><td>27,596</td><td>47,871 (30.6 %)</td><td>24,844</td><td>44,567 (19.2 %)</td><td>153,173</td><td>212,261 (16.2 %)</td><td>0</td><td>391,709 (24.8 %)</td></tr><tr><td> Had hepatic injury/chronic hepatic condition in the baseline</td><td>10,592</td><td>37,279 (23.8 %)</td><td>9173</td><td>35,394 (15.3 %)</td><td>39,354</td><td>172,907 (13.2 %)</td><td>76,815</td><td>314,894 (20.0 %)</td></tr><tr><td> Region affected by Hurricane Katrina</td><td>489</td><td>36,790 (23.5 %)</td><td>509</td><td>34,885 (15.1 %)</td><td>2020</td><td>170,887 (13.0 %)</td><td>3556</td><td>311,338 (19.7 %)</td></tr><tr><td>Cohort assignment based on earliest qualifying index date (pre-propensity score matching)</td><td colspan="2">30,844 (19.7 %)</td><td colspan="2">29,243 (12.6 %)</td><td colspan="2">166,236 (12.6 %)</td><td colspan="2">311,338 (19.7 %)</td></tr></table>
136b31a57aa2e876ad816db2f179c9646a4d110764aa92d81ba22cbdc769a6f7.png
complex
<table><tr><td>Characteristic</td><td>No. of patients</td><td>Percent</td></tr><tr><td colspan="3">Age</td></tr><tr><td> &#8804;75</td><td>31</td><td>51</td></tr><tr><td> &gt;75</td><td>30</td><td>49</td></tr><tr><td colspan="3">Gender</td></tr><tr><td> Male</td><td>20</td><td>33</td></tr><tr><td> Female</td><td>41</td><td>67</td></tr><tr><td colspan="3">ECOG performance status</td></tr><tr><td> 0</td><td>4</td><td>7</td></tr><tr><td> 1</td><td>28</td><td>46</td></tr><tr><td> 2</td><td>22</td><td>36</td></tr><tr><td> 3</td><td>7</td><td>11</td></tr><tr><td colspan="3">Smoking status</td></tr><tr><td> Never</td><td>4</td><td>7</td></tr><tr><td> Former</td><td>44</td><td>72</td></tr><tr><td> Current</td><td>13</td><td>21</td></tr><tr><td colspan="3">Tobacco history (pack-years)</td></tr><tr><td> 0</td><td>4</td><td>7</td></tr><tr><td> &lt;40</td><td>20</td><td>33</td></tr><tr><td> 40&#8211;50</td><td>21</td><td>34</td></tr><tr><td> &gt;50</td><td>16</td><td>26</td></tr><tr><td colspan="3">Baseline oxygen dependence</td></tr><tr><td> Yes</td><td>19</td><td>31</td></tr><tr><td> No</td><td>42</td><td>69</td></tr><tr><td colspan="3">Reason for inoperability</td></tr><tr><td> Age</td><td>11</td><td>18</td></tr><tr><td> Pulmonary dysfunction</td><td>49</td><td>80</td></tr><tr><td> Other medical comorbidities</td><td>1</td><td>2</td></tr></table>
a2ba432aba779b42a897fa7f1dddb8cd23626e6c0e7870f891e0391e35172080.png
simple
<table><tr><td>Variables</td><td>AUC</td><td>Cut-off</td><td>Sensitivity (%)</td><td>Specificity (%)</td></tr><tr><td>CAR</td><td>0.641</td><td>0.03</td><td>54</td><td>73</td></tr><tr><td>NLR</td><td>0.560</td><td>3.13</td><td>28</td><td>88</td></tr><tr><td>PLR</td><td>0.538</td><td>188</td><td>28</td><td>83</td></tr><tr><td>PNI</td><td>0.631</td><td>49.2</td><td>78</td><td>49</td></tr><tr><td>GPS</td><td>0.543</td><td>0</td><td>24</td><td>84</td></tr><tr><td>PI</td><td>0.541</td><td>0</td><td>17</td><td>92</td></tr></table>
3982c3f5a5476d81ade40ada1ae141387d08b338f035f48468ac546ae9bbbdbf.png
complex
<table><tr><td></td><td colspan="7">discovery cohort</td><td colspan="2">validation cohort</td></tr><tr><td>ProbeSet Name</td><td>miRNA</td><td>R-SW</td><td>last/first (SW)</td><td>FC (elder/young) LIMMA</td><td>adj.P.Val LIMMA</td><td>RQ (Qpcr)</td><td>p-value</td><td>RQ (Qpcr)</td><td>p-value</td></tr><tr><td>hsa-miR-1281_st</td><td>miR-1281</td><td>0.921</td><td>2.778</td><td>2.509</td><td>4.64E-03</td><td>1.127</td><td>6.60E-01</td><td>-</td><td>-</td></tr><tr><td>hsa-let-7i_st</td><td>let-7i</td><td>&#8722;0.853</td><td>0.498</td><td>0.455</td><td>4.64E-03</td><td>0.566</td><td>2.86E-02</td><td>0.226</td><td>1.53E-07</td></tr><tr><td>hsa-miR-30b_st</td><td>miR-30b</td><td>&#8722;0.839</td><td>0.476</td><td>0.503</td><td>1.05E-01</td><td>0.777</td><td>1.07E-01</td><td>0.419</td><td>7.66E-07</td></tr><tr><td>hsa-miR-15a_st</td><td>miR-15a</td><td>&#8722;0.874</td><td>0.465</td><td>0.525</td><td>9.39E-02</td><td>0.632</td><td>1.21E-01</td><td>0.219</td><td>1.23E-07</td></tr><tr><td>hsa-let-7g_st</td><td>let-7g</td><td>&#8722;0.899</td><td>0.434</td><td>0.468</td><td>1.54E-02</td><td>0.578</td><td>1.14E-02</td><td>0.199</td><td>1.05E-08</td></tr></table>
f136189951288dbd356959615c89022745e7ab36cc05ca8d62018af564134047.png
complex
<table><tr><td colspan="5">Positive Association with ER&#945;</td></tr><tr><td></td><td>qRT-PCR</td><td>METABRIC*</td><td>TCGA<sup>#</sup></td><td>GSE20685<sup>&#167;</sup></td></tr><tr><td>Sample No. Analysed</td><td><i>n</i> = 128</td><td><i>n</i> = 1,980</td><td><i>n</i> = 485</td><td><i>n</i> = 327</td></tr><tr><td>ER&#945;</td><td>3.6E-18</td><td>2.4E-188</td><td>2.8E-47</td><td>9.6E-48</td></tr><tr><td>PGR</td><td>4.6E-11</td><td>9.6E-102</td><td>1.7E-29</td><td>6.4E-34</td></tr><tr><td>PNR</td><td>1.9E-10</td><td>4.9E-110</td><td>1.8E-34</td><td>1.5E-11</td></tr><tr><td></td><td>AR</td><td>7.6E-60</td><td>7.8E-28</td><td>8.0E-16</td></tr><tr><td>ROR&#946;</td><td>1.9E-06</td><td>1.7E-06</td><td>1.2E-02</td><td>3.4E-01</td></tr><tr><td>RAR&#945;</td><td>1.3E-06</td><td>3.0E-88</td><td>1.2E-24</td><td>1.3E-07</td></tr><tr><td>TR&#946;</td><td>9.2E-05</td><td>8.1E-01</td><td>1.7E-08</td><td>1.4E-08</td></tr><tr><td>ROR&#947;</td><td>2.6E-04</td><td>2.3E-44</td><td>1.5E-15</td><td>7.3E-08</td></tr><tr><td>LRH-1</td><td>1.9E-03</td><td>4.1E-03</td><td>5.8E-04</td><td>2.9E-01</td></tr><tr><td>ERR&#947;</td><td>6.0E-01</td><td>1.8E-05</td><td>4.4E-02</td><td>3.1E-01</td></tr><tr><td colspan="5">Negative Association with ER&#945;</td></tr><tr><td></td><td>qRT-PCR</td><td>METABRIC</td><td>TCGA</td><td>GSE20685</td></tr><tr><td>TLX</td><td>5.5E-07</td><td>2.7E-10</td><td>1.6E-15</td><td>1.3E-02</td></tr><tr><td>PPAR&#945;</td><td>3.3E-04</td><td>1.1E-34</td><td>4.3E-28</td><td>1.4E-12</td></tr><tr><td>DAX1</td><td>2.9E-02</td><td>1.7E-02</td><td>4.0E-03</td><td>6.7E-01</td></tr></table>
8274571a794f877a13dac447b6c4798b2dc44eb7487cddd1ae39437036f0d7ed.png
complex
<table><tr><td>Characteristic</td><td colspan="2">1 Portion Group (n=35)</td><td colspan="2">6 Portion Group (n=39)</td><td>Trend for change</td></tr><tr><td> </td><td>Pre</td><td>Post</td><td>Pre</td><td>Post</td><td>between groups</td></tr><tr><td>Male Sex (%)</td><td>80</td><td>-</td><td>61.5</td><td>-</td><td>0.295</td></tr><tr><td>BMI (kg/m<sup>2</sup>)</td><td>30.1 (0.6)</td><td>30.1 (0.7)</td><td>30.7 (0.6)</td><td>31.0 (0.6)<sup>d</sup></td><td>0.012</td></tr><tr><td>Age (years)</td><td>59.9 (1.23)</td><td>-</td><td>58.2 (1.47)</td><td>-</td><td>0.263</td></tr><tr><td>Glucose (mmol/L)</td><td>8.0 (6.6,9.6)</td><td>8.5 (7.5,22.3)</td><td>8.2 (7.0,8.9)</td><td>8.9 (8.3,18.8)</td><td>0.587</td></tr><tr><td>Insulin (mU/L)</td><td>13.7 (9.4,21.2)</td><td>14.6 (7.5,22.3)</td><td>11.9 (8.0,17.4)</td><td>16.8 (8.3,18.8)</td><td>0.470</td></tr><tr><td>HbA1C (%)</td><td>7.2 (0.2)</td><td>7.1 (0.2)<sup>c</sup></td><td>7.1 (0.2)</td><td>7.1 (0.2)</td><td>0.068</td></tr><tr><td>Duration of diabetes (years)</td><td>6.7 (0.9)</td><td>-</td><td>5.2 (0.7)</td><td>-</td><td>&gt;0.05</td></tr><tr><td>Triglycerides (mmol/L)</td><td>1.82 (1.2,2.1)</td><td>1.69 (1.1,2.1)</td><td>1.73 (1.1,2.0)</td><td>1.79 (1.2,2.2)</td><td>0.168</td></tr><tr><td>Total cholesterol (mmol/L)</td><td>3.95 (0.13)</td><td>3.86 (0.11)</td><td>3.87 (0.12)</td><td>3.93 (0.12)</td><td>0.640</td></tr><tr><td>HDL cholesterol (mmol/L)</td><td>1.24 (0.05)</td><td>1.20 (0.05)</td><td>1.25 (0.05)</td><td>1.23 (0.05)</td><td>0.194</td></tr><tr><td>Lipid lowering therapy (%)</td><td>94</td><td>-</td><td>95</td><td>-</td><td>&gt;0.05</td></tr><tr><td>Diabetic therapy (diet) (%)</td><td>5</td><td>-</td><td>8</td><td>-</td><td>&gt;0.05</td></tr><tr><td>Oral hypoglycaemic therapy (%)</td><td>86</td><td>-</td><td>80</td><td>-</td><td>&gt;0.05</td></tr></table>
5ffff5cbabe6ad0c32b41af073bb5bdb2a61a339c260eaed970ed70964c5bbda.png
simple
<table><tr><td>Data set 1</td><td>Gene</td><td>Mutation</td><td>Tissue</td><td>Mean coverage</td><td>PCR/CE</td><td>ScanIndel</td><td>GATK</td><td>Pindel</td><td>Scalpel</td><td>Platypus</td><td>FermiKit</td><td>Delly</td></tr><tr><td>1-1</td><td><i>CALR</i></td><td>DEL</td><td>BM</td><td>46,913</td><td>52</td><td>52</td><td>52</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td></tr><tr><td>1-2</td><td><i>EGFR</i></td><td>DEL</td><td>FFPE</td><td>25,821</td><td>18</td><td>18</td><td>18</td><td>NC</td><td>NC</td><td>18</td><td>NC</td><td>NC</td></tr><tr><td>1-3</td><td><i>KIT</i></td><td>DEL</td><td>FFPE</td><td>12,990</td><td>6</td><td>6</td><td>6</td><td>NC</td><td>NC</td><td>6</td><td>NC</td><td>NC</td></tr><tr><td>1-4</td><td><i>NPM1</i></td><td>INS</td><td>BM</td><td>21,387</td><td>4</td><td>4</td><td>4</td><td>4</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td></tr><tr><td>1-5</td><td><i>FLT3</i></td><td>INS</td><td>BM</td><td>4768</td><td>21</td><td>21</td><td>21</td><td>21</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td></tr><tr><td>1-6</td><td><i>FLT3</i></td><td>INS</td><td>BM</td><td>11,510</td><td>26</td><td>27</td><td>NC</td><td>27</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td></tr><tr><td>1-7</td><td><i>FLT3</i></td><td>INS</td><td>BM</td><td>26,747</td><td>49</td><td>51</td><td>NC</td><td>51</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td></tr><tr><td>1-8</td><td><i>FLT3</i></td><td>INS</td><td>BM</td><td>28,991</td><td>38</td><td>39</td><td>NC</td><td>39</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td></tr><tr><td>1-9</td><td><i>FLT3</i></td><td>INS</td><td>BM</td><td>26,734</td><td>90</td><td>93</td><td>NC</td><td>93</td><td>NC</td><td>NC</td><td>93</td><td>NC</td></tr><tr><td>1-10</td><td><i>FLT3</i></td><td>INS</td><td>BM</td><td>16,152</td><td>75</td><td>78</td><td>NC</td><td>78</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td></tr><tr><td>1-11</td><td><i>FLT3</i></td><td>INS</td><td>BM</td><td>3528</td><td>32</td><td>33</td><td>33</td><td>33</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td></tr><tr><td>1-12</td><td><i>FLT3</i></td><td>INS</td><td>BM</td><td>3851</td><td>51</td><td>54</td><td>54</td><td>54</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td></tr><tr><td>1-13</td><td><i>FLT3</i></td><td>INS</td><td>BM</td><td>21,403</td><td>23</td><td>24</td><td>24</td><td>24</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td></tr><tr><td>1-14</td><td><i>FLT3</i></td><td>INS</td><td>BM</td><td>3070</td><td>45</td><td>48</td><td>48</td><td>48</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td></tr><tr><td>1-15</td><td><i>FLT3</i></td><td>INS</td><td>BM</td><td>4506</td><td>33</td><td>36</td><td>36</td><td>36</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td></tr><tr><td>1-16</td><td><i>FLT3</i></td><td>NEG</td><td>BM</td><td>4471</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td></tr><tr><td>1-17</td><td><i>FLT3</i></td><td>NEG</td><td>BM</td><td>4321</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td></tr><tr><td>1-18</td><td><i>FLT3</i></td><td>NEG</td><td>BM</td><td>6219</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td></tr><tr><td>1-19</td><td><i>FLT3</i></td><td>NEG</td><td>BM</td><td>5259</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td></tr><tr><td>1-20</td><td><i>FLT3</i></td><td>NEG</td><td>BM</td><td>4443</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td></tr><tr><td>1-21</td><td><i>FLT3</i></td><td>NEG</td><td>BM</td><td>5236</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td></tr><tr><td>1-22</td><td><i>FLT3</i></td><td>NEG</td><td>BM</td><td>4443</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td><td>NC</td></tr></table>
e67a0422c1aa4ce87508fa98a8e7c51c2a93d4c497df71ca9bdefe776b799475.png
complex
<table><tr><td rowspan="3"></td><td colspan="4">Rotated component matrix</td></tr><tr><td colspan="4">Component</td></tr><tr><td>1</td><td>2</td><td>3</td><td>4</td></tr><tr><td>E1</td><td>.772</td><td></td><td></td><td></td></tr><tr><td>E2</td><td>.720</td><td></td><td></td><td></td></tr><tr><td>E3</td><td>.786</td><td></td><td></td><td></td></tr><tr><td>E4</td><td>.839</td><td></td><td></td><td></td></tr><tr><td>E5</td><td>.781</td><td></td><td></td><td></td></tr><tr><td>E6</td><td>.840</td><td></td><td></td><td></td></tr><tr><td>E7</td><td>.824</td><td></td><td></td><td></td></tr><tr><td>E8</td><td>.787</td><td></td><td></td><td></td></tr><tr><td>T1</td><td></td><td>.699</td><td></td><td></td></tr><tr><td>T2</td><td></td><td>.843</td><td></td><td></td></tr><tr><td>T3</td><td></td><td>.845</td><td></td><td></td></tr><tr><td>T4</td><td></td><td>.827</td><td></td><td></td></tr><tr><td>A1</td><td></td><td></td><td></td><td>.823</td></tr><tr><td>A2</td><td></td><td></td><td></td><td>.824</td></tr><tr><td>A3</td><td></td><td></td><td></td><td>.518</td></tr><tr><td>P1</td><td></td><td></td><td>.764</td><td></td></tr><tr><td>P2</td><td></td><td></td><td>.740</td><td></td></tr><tr><td>P3</td><td></td><td></td><td>.816</td><td></td></tr><tr><td>O1</td><td></td><td></td><td>.761</td><td></td></tr></table>
5b3f94b83204fd46b0413541113dd4aaa2ad0fdf5e500e7f09562fd69e40fe58.png
complex
<table><tr><td rowspan="2">Quintile</td><td colspan="2"><i>n</i></td><td colspan="2">Energy (kcal/Person/Day)</td><td colspan="2">Sodium (g/Person/Day)</td><td colspan="2">Sodium (g/Person/Day/2000kcal)</td></tr><tr><td>2004&#8211;2005</td><td>2012&#8211;2013</td><td>2004&#8211;2005</td><td>2012&#8211;2013</td><td>2004&#8211;2005</td><td>2012&#8211;2013</td><td>2004&#8211;2005</td><td>2012&#8211;2013</td></tr><tr><td>Costa Rica</td><td>1,134,433</td><td>1,396,747</td><td>2315</td><td>2390</td><td>3.9</td><td>4,6 <sup>a</sup></td><td>3.4</td><td>3.9 <sup>a</sup></td></tr><tr><td>I</td><td>225,773</td><td>279,044</td><td>1896</td><td>1724</td><td>3.9</td><td>3,8 <sup>b</sup></td><td>4.1</td><td>4.4 <sup>b</sup></td></tr><tr><td>II</td><td>226,647</td><td>279,642</td><td>2065</td><td>2195</td><td>3.5</td><td>4.7 <sup>a</sup></td><td>3.4</td><td>4.3 <sup>a</sup></td></tr><tr><td>III</td><td>228,332</td><td>279,437</td><td>2276</td><td>2494</td><td>4.0</td><td>4.7</td><td>3.5</td><td>3.8</td></tr><tr><td>IV</td><td>226,503</td><td>279,409</td><td>2626</td><td>2679</td><td>4.4</td><td>4.9 <sup>a</sup></td><td>3.4</td><td>3.7 <sup>a</sup></td></tr><tr><td>V</td><td>227,178</td><td>279,215</td><td>2712</td><td>2669</td><td>3.9</td><td>4.7 <sup>a</sup></td><td>2.9</td><td>3.5 <sup>a</sup></td></tr></table>
b5b2b8047b9dd35d501cfea6e21c7836501ba0686999e024b678884326e95379.png
complex
<table><tr><td>Gene name</td><td> </td><td>Sequence (5&#8217;-3&#8217;)</td><td>Primer</td><td>Purpose</td><td>Acc.</td></tr><tr><td> </td><td> </td><td> </td><td>efficiency (%)</td><td> </td><td>number</td></tr><tr><td rowspan="2">Profilin2 (<i>Pfn2</i>)</td><td>F<sup>1</sup></td><td>CCAGCCACTCAATATGTCGT</td><td rowspan="2"> </td><td rowspan="2">cloning</td><td rowspan="2">[GenBank:KC460541]</td></tr><tr><td>R<sup>2</sup></td><td>CAAGAACCTGGGAAACACAC</td></tr><tr><td rowspan="2"> </td><td>F</td><td>ATCGCAGCACTTTATTCACC</td><td rowspan="2">95.18</td><td rowspan="2">qPCR</td><td rowspan="2"> </td></tr><tr><td>R</td><td>GCGTCCTCCTTGTAGAGGTT</td></tr><tr><td rowspan="2">Peroxiredoxin 6 (<i>Prdx6</i>)</td><td>F</td><td>TATCGGTGAGACAGGACCAT</td><td rowspan="2"> </td><td rowspan="2">cloning</td><td rowspan="2">[GenBank:KC460539]</td></tr><tr><td>R</td><td>TGGCGGTTTATTCTAAGTGC</td></tr><tr><td rowspan="2"> </td><td>F</td><td>GATGAGATCGACAAGGATGG</td><td rowspan="2">96.99</td><td rowspan="2">qPCR</td><td rowspan="2"> </td></tr><tr><td>R</td><td>TCTATGACCCTCAGCAGCTC</td></tr><tr><td rowspan="2">Flotillin1 (<i>Flot1</i>)</td><td>F</td><td>TCGCTGAAATAGGTCTCTGG</td><td rowspan="2"> </td><td rowspan="2">cloning</td><td rowspan="2">[GenBank:KC460542]</td></tr><tr><td>R</td><td>ACTCAGCCTTCTTGGTGTTG</td></tr><tr><td rowspan="2"> </td><td>F</td><td>ACCAGGACTACCTCCACTCC</td><td rowspan="2">91.88</td><td rowspan="2">qPCR</td><td rowspan="2"> </td></tr><tr><td>R</td><td>TACTGGGCAGACACCTTCTC</td></tr><tr><td rowspan="2">Calpain small subunit 1 (<i>Capns1</i>)</td><td>F</td><td>TTCTCTTCTCACCGCAGAAC</td><td rowspan="2"> </td><td rowspan="2">cloning</td><td rowspan="2">[GenBank:KC460540]</td></tr><tr><td>R</td><td>GACTTTTCCAGCTCCTCCTC</td></tr><tr><td rowspan="2"> </td><td>F</td><td>AACATGGCAACATGGACTTT</td><td rowspan="2">94.05</td><td rowspan="2">qPCR</td><td rowspan="2"> </td></tr><tr><td>R</td><td>TTGACATCAAGGGAGATGGT</td></tr><tr><td rowspan="2">Beta 2 Tubulin (<i>Tubb2</i>)</td><td>F</td><td>CAGCTACTTCGTGGAATGGA</td><td rowspan="2">94.47</td><td rowspan="2">qPCR</td><td rowspan="2">[GenBank:AAD56401]</td></tr><tr><td>R</td><td>CTGTTGCCGATGAAGGTTAC</td></tr><tr><td rowspan="2">Cold inducible RNA binding protein (<i>Cirbp</i>)</td><td>F</td><td>CTCTTCGGAACTCTCAACCA</td><td rowspan="2"> </td><td rowspan="2">cloning</td><td rowspan="2">[GenBank:KC460543]</td></tr><tr><td>R</td><td>AATACAGCCAGCCAAGTGAC</td></tr><tr><td rowspan="2"> </td><td>F</td><td>GTATGGAAACATCGCCAAAG</td><td rowspan="2">94.17</td><td rowspan="2">qPCR</td><td rowspan="2"> </td></tr><tr><td>R</td><td>CTCGTCGGCATTATCAAACT</td></tr><tr><td rowspan="2">Glutathione S-transferase omega1(<i>Gsto1</i>)</td><td>F</td><td>ATTGCGTCTTGGTCATTCAT</td><td rowspan="2"> </td><td rowspan="2">cloning</td><td rowspan="2">[GenBank:KC460544]</td></tr><tr><td>R</td><td>ACAGGCCATAGTCGTAGTCG</td></tr><tr><td rowspan="2"> </td><td>F</td><td>CTGAAACACTTCCTGGATGG</td><td rowspan="2">95.60</td><td rowspan="2">qPCR</td><td rowspan="2"> </td></tr><tr><td>R</td><td>GCGTGCATGGTTTCTTTAAC</td></tr><tr><td rowspan="2">Ubiquitin (<i>Ubi</i>)</td><td>F</td><td>GGCCGCAAAGATGCAGAT</td><td rowspan="2">96.10</td><td rowspan="2">qPCR</td><td rowspan="2">[GenBank:EX735613]</td></tr><tr><td>R</td><td>CTGGGCTCGACCTCAAGAGT</td></tr><tr><td rowspan="2">Acidic ribosomal protein (<i>Arp</i>)</td><td>F</td><td>TGATCCTCCACGACGATGAG</td><td rowspan="2">95.37</td><td rowspan="2">qPCR</td><td rowspan="2">[GenBank:EX741373]</td></tr><tr><td>R</td><td>CAGGGCCTTGGCGAAGA</td></tr><tr><td>Interleukin 1&#946; (<i>il1&#946;</i>)</td><td>F</td><td>GGAGAACACGGACGACCTGA</td><td> </td><td>qPCR</td><td>[GenBank:AJ535730]</td></tr><tr><td> </td><td>R</td><td>CGCACCATGTCACTGTCCTT</td><td> </td><td> </td><td> </td></tr></table>
39a4296adcd4615c461ac1c50365a480f379e8fb3a579128e3f7c2a53ec24684.png
complex
<table><tr><td>Primer</td><td>Sequence (5&#8242;&#8594;3&#8242;)</td><td>Length (bp)</td></tr><tr><td><i>lytA</i>-ins F</td><td>GAAGATCTAGATTTGCCTCAAGTCGG</td><td rowspan="2">421</td></tr><tr><td><i>lytA</i>-ins R</td><td>CCCCCGGGAGGGTCAACGTGGTCTGA</td></tr><tr><td><i>lytA</i> Fexp BamH I</td><td>GGGGATCCATGGAAATTAATGTGAGTAAAT</td><td rowspan="2">6,723</td></tr><tr><td><i>lytA</i> Rexp Xho I</td><td>CCGCTCGAGTTTTACTGTAATCAAGCCATC</td></tr><tr><td><i>pEVP3</i> F</td><td>ATCTCAGTTCGGTGTAGGTC</td><td rowspan="2">1,068</td></tr><tr><td><i>pEVP3</i> R</td><td>TTATTGGGATAAGTTAGAGCC</td></tr><tr><td><i>ply</i> F</td><td>ATGGCAAATAAAGCAGTAAATGACT</td><td rowspan="2">1,416</td></tr><tr><td><i>ply</i> R</td><td>CTAGTCATTTTCTACCTTATCCTCT</td></tr></table>
326950c69bad56a3db4b1baf8abde395b58eed3d8dd38f1a5b92259b2b4964ef.png
complex
<table><tr><td>Parameter</td><td>Hazard ratio (95% confidence interval)</td><td><i>P</i> value</td></tr><tr><td colspan="3">Myasthenia gravis</td></tr><tr><td> Yes vs. no</td><td>3.807 (0.465, 31.153)</td><td>0.213</td></tr><tr><td colspan="3">Surgery</td></tr><tr><td> Yes vs. no</td><td>1.055 (0.766, 1.453)</td><td>0.744</td></tr><tr><td colspan="3">Metastasis</td></tr><tr><td> Lymphogenous vs. hematogenous</td><td>2.580 (1.341, 4.967)</td><td>0.005</td></tr></table>
3747cfcdb3bf5868c9e68297d501bb96a61159262d603b347edbdf60210ccb4b.png
complex
<table><tr><td> </td><td>TOLAC hospital (N=139) N (%) or Mean (SD)</td></tr><tr><td>Anesthesia</td><td> </td></tr><tr><td>In-hospital</td><td>129 (93.5)</td></tr><tr><td>Within 30 minutes</td><td rowspan="2">9 (6.5)</td></tr><tr><td><i>Missing=1</i></td></tr><tr><td>Physician</td><td> </td></tr><tr><td>In-hospital</td><td>117 (87.3)</td></tr><tr><td>Within 20-30 minutes</td><td rowspan="2">17 (12.7)</td></tr><tr><td><i>Missing =5</i></td></tr><tr><td>Operating room immediately available</td><td>134 (96.4)</td></tr><tr><td>Neonatal staff available</td><td>136 (97.8)</td></tr><tr><td>Day of the week restrictions</td><td> </td></tr><tr><td> No restrictions</td><td>135 (97.1)</td></tr><tr><td> Day of the week</td><td>2 (1.4)</td></tr><tr><td> Time of day</td><td>0</td></tr><tr><td>Patient Restrictions</td><td> </td></tr><tr><td> Number of prior cesareans</td><td>131 (94.2)</td></tr><tr><td> One prior cesarean</td><td>45 (32.4)</td></tr><tr><td> No more than two prior cesareans</td><td>86 (61.8)</td></tr><tr><td> Singleton pregnancy</td><td>83 (59.7)</td></tr><tr><td> Time since last birth</td><td>11 (7.9)</td></tr><tr><td> Weight or body mass index</td><td>2 (1.4)</td></tr><tr><td> Spontaneous labor</td><td>73 (52.5)</td></tr><tr><td>Induction or labor management methods permitted</td><td> </td></tr><tr><td> Prostaglandin gel/insert</td><td>2 (1.4)</td></tr><tr><td> Foley</td><td>66 (48.9)</td></tr><tr><td> Oxytocin</td><td>128 (92.1)</td></tr><tr><td> Amniotomy</td><td>131 (94.2)</td></tr><tr><td>Requirements of women with a TOLAC</td><td> </td></tr><tr><td> Continuous fetal monitoring</td><td>138 (99.2)</td></tr><tr><td> Continuous IV</td><td>138 (99.2)</td></tr><tr><td> Epidural in active labor</td><td>27 (19.4)</td></tr></table>
4ddfdde86d4ad4aca85610f24f9e2976ad3c4b89cf10c0c7564fd927d8a2534b.png
simple
<table><tr><td>Sliding Window Segmentation Approach</td><td>Window Overlap Value (%)</td><td>Window Size</td><td>Highest Classification Accuracy (%)</td></tr><tr><td>No Overlap</td><td>0</td><td>4.5</td><td>96.12</td></tr><tr><td>Overlap</td><td>25</td><td>6</td><td>96.97</td></tr><tr><td>Overlap</td><td>50</td><td>6</td><td>97.30</td></tr><tr><td>Overlap</td><td>75</td><td>8</td><td>98.13</td></tr><tr><td>Overlap</td><td>90</td><td>12</td><td>98.38</td></tr></table>
d1e7eb3cb7d44224785014a27dc715cc12e872c5c94b773ed4bfda6354fdf598.png
simple
<table><tr><td> </td><td><i>Number of participants</i></td><td><i>Mean</i></td><td><i>s.d.</i></td><td><i>Median</i></td><td>P<i>-value</i></td></tr><tr><td>Bipolar lithium</td><td>30</td><td>3.04</td><td>0.43</td><td>3.05</td><td>0.04a</td></tr><tr><td>Bipolar non-lithium</td><td>27</td><td>3.31</td><td>0.49</td><td>3.31</td><td> </td></tr><tr><td>Controls</td><td>22</td><td>3.12</td><td>0.21</td><td>3.07</td><td> </td></tr><tr><td>Total</td><td>79</td><td>3.16</td><td>0.42</td><td>3.10</td><td> </td></tr></table>
62ebcd856b0a47078bb881ab2ce765bd07a8441d199e0adaaea582d7e7b0a966.png
simple
<table><tr><td>Variable</td><td>PD (n = 230)</td><td>Controls (n = 93)</td><td><i>P</i></td></tr><tr><td>Age at study enrollment (years)</td><td>66.4 (9.5)</td><td>68.0 (8.0)</td><td>0.118</td></tr><tr><td>Disease duration at study enrollment (years)</td><td>0.6 (0.5)</td><td></td><td></td></tr><tr><td>Sex (% male)</td><td>61.7</td><td>52.7</td><td>0.134</td></tr><tr><td>Age leaving full&#8208;time education (years)</td><td>17.8 (3.7)</td><td>18.0 (3.4)</td><td>0.604</td></tr><tr><td>UPDRS&#8208;III</td><td>27.9 (11.5)</td><td></td><td></td></tr><tr><td>MMSE</td><td>28.8 (1.3)</td><td>29.0 (1.2)</td><td>0.078</td></tr><tr><td>GDS&#8208;15</td><td>2.9 (2.6)</td><td>1.0 (1.6)</td><td>&lt; 0.001</td></tr><tr><td>LEDD (mg)</td><td>194.5 (161.5)</td><td></td><td></td></tr><tr><td>CIRS systems score, median, (range)</td><td>2 (0&#8211;7)</td><td>3 (0&#8211;7)</td><td>0.070</td></tr><tr><td>Anti&#8208;inflammatory drug use (%)</td><td>32.6</td><td>33.3</td><td>0.900</td></tr></table>
97853ba9bd9efe457cc16594fa35afcd5c02f51d6f9b16f5f27fc19119eb16b1.png
complex
<table><tr><td>Sensitive</td><td colspan="4">Species</td></tr><tr><td>coefficients</td><td><i>S. baicalensis</i></td><td><i>S. grandis</i></td><td><i>S. breviflora</i></td><td><i>S. bungeana</i></td></tr><tr><td colspan="5">TEMPERATURE TREATMENTS</td></tr><tr><td>T<sub>0</sub></td><td>&#8722;0.10</td><td>0.25</td><td>&#8722;0.09</td><td>&#8722;0.18</td></tr><tr><td>T<sub>1.5</sub></td><td>1.89</td><td>0.12</td><td>1.95</td><td>6.04</td></tr><tr><td>T<sub>2.0</sub></td><td>3.12</td><td>1.31</td><td>3.13</td><td>4.85</td></tr><tr><td>T<sub>4.0</sub></td><td>0.76</td><td>&#8722;0.14</td><td>2.22</td><td>5.21</td></tr><tr><td>T<sub>6.0</sub></td><td>0.74</td><td>&#8722;5.16</td><td>2.06</td><td>5.64</td></tr><tr><td colspan="5">PRECIPITATION TREATMENTS</td></tr><tr><td>W<sub>&#8722;30%</sub></td><td>&#8722;0.46</td><td>&#8722;9.59</td><td>&#8722;1.54</td><td>3.15</td></tr><tr><td>W<sub>&#8722;15%</sub></td><td>6.32</td><td>&#8722;6.97</td><td>&#8722;0.07</td><td>9.45</td></tr><tr><td>W<sub>0</sub></td><td>3.21</td><td>&#8722;0.45</td><td>3.62</td><td>8.44</td></tr><tr><td>W<sub>+15%</sub></td><td>0.23</td><td>1.44</td><td>1.57</td><td>11.95</td></tr><tr><td>W<sub>+30%</sub></td><td>&#8722;1.03</td><td>4.24</td><td>&#8722;1.28</td><td>3.73</td></tr></table>
8280e9ec217a0bf0d0a6c34c5c03cd95f797497f9e84e2710b351f0d0f7c170a.png
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<table><tr><td></td><td colspan="3">Pressure level 1</td><td colspan="3">Pressure level 2</td></tr><tr><td>Comparison</td><td>Diff of Ranks</td><td>Q</td><td>P &lt; 0.05</td><td>Diff of Ranks</td><td>Q</td><td>P &lt; 0.05</td></tr><tr><td>Control vs Wood</td><td>0.600</td><td>1.897</td><td>No</td><td>1.120</td><td>3.542</td><td>Yes</td></tr><tr><td>Control vs Metal</td><td>0.210</td><td>0.664</td><td>No</td><td>0.140</td><td>0.443</td><td>No</td></tr><tr><td>Control vs Acrylic</td><td>1.830</td><td>5.787</td><td>Yes</td><td>0.740</td><td>2.340</td><td>No</td></tr><tr><td>Control vs Sandpaper</td><td>2.130</td><td>6.736</td><td>Yes</td><td>1.670</td><td>5.281</td><td>Yes</td></tr><tr><td>Wood vs Metal</td><td>0.390</td><td>1.233</td><td>No</td><td>0.980</td><td>3.099</td><td>Yes</td></tr><tr><td>Wood vs Acrylic</td><td>2.430</td><td>7.684</td><td>Yes</td><td>1.860</td><td>5.882</td><td>Yes</td></tr><tr><td>Wood vs Sandpaper</td><td>2.730</td><td>8.633</td><td>Yes</td><td>2.790</td><td>8.823</td><td>Yes</td></tr><tr><td>Metal vs Acrylic</td><td>2.040</td><td>6.451</td><td>Yes</td><td>0.880</td><td>2.783</td><td>No</td></tr><tr><td>Metal vs Sandpaper</td><td>2.340</td><td>7.400</td><td>Yes</td><td>1.810</td><td>5.724</td><td>Yes</td></tr><tr><td>Acrylic vs Sandpaper</td><td>0.300</td><td>0.949</td><td>No</td><td>0.930</td><td>2.941</td><td>Yes</td></tr><tr><td></td><td colspan="3">Pressure level 3</td><td colspan="3">Pressure level 4</td></tr><tr><td>Comparison</td><td>Diff of Ranks</td><td>Q</td><td>P &lt; 0.05</td><td>Diff of Ranks</td><td>Q</td><td>P &lt; 0.05</td></tr><tr><td>Control vs Wood</td><td>0.600</td><td>1.897</td><td>No</td><td>0.400</td><td>1.265</td><td>No</td></tr><tr><td>Control vs Metal</td><td>0.210</td><td>0.664</td><td>No</td><td>0.450</td><td>1.423</td><td>No</td></tr><tr><td>Control vs Acrylic</td><td>0.040</td><td>0.126</td><td>No</td><td>1.380</td><td>4.364</td><td>Yes</td></tr><tr><td>Control vs Sandpaper</td><td>1.200</td><td>3.795</td><td>Yes</td><td>1.570</td><td>4.965</td><td>Yes</td></tr><tr><td>Wood vs Metal</td><td>0.810</td><td>2.561</td><td>No</td><td>0.050</td><td>0.158</td><td>No</td></tr><tr><td>Wood vs Acrylic</td><td>0.640</td><td>2.024</td><td>No</td><td>0.980</td><td>3.099</td><td>Yes</td></tr><tr><td>Wood vs Sandpaper</td><td>1.800</td><td>5.692</td><td>Yes</td><td>1.170</td><td>3.700</td><td>Yes</td></tr><tr><td>Metal vs Acrylic</td><td>0.170</td><td>0.538</td><td>No</td><td>0.930</td><td>2.941</td><td>Yes</td></tr><tr><td>Metal vs Sandpaper</td><td>0.990</td><td>3.131</td><td>Yes</td><td>1.120</td><td>3.542</td><td>Yes</td></tr><tr><td>Acrylic vs Sandpaper</td><td>1.160</td><td>3.668</td><td>Yes</td><td>0.190</td><td>0.601</td><td>No</td></tr></table>
46511a3ef1376d279d637a8ff92b227ce0e61ee21d5f83deca693f8307c95faa.png
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<table><tr><td>Number of patients N</td><td>24</td></tr><tr><td>Mean age</td><td>64</td></tr><tr><td>Minimum age</td><td>46</td></tr><tr><td>Maximum age</td><td>83</td></tr><tr><td>Standard deviation</td><td>12</td></tr><tr><td>Male: Female</td><td>11 : 13</td></tr><tr><td>Location of primary cancer (%)</td><td> </td></tr><tr><td>Tongue</td><td>12 (50%)</td></tr><tr><td>Floor of mouth</td><td>3 (13%)</td></tr><tr><td>Retromolar trigone</td><td>2 (8%)</td></tr><tr><td>Larynx</td><td>2 (8%)</td></tr><tr><td>Oropharynx</td><td>2 (8%)</td></tr><tr><td>Alveolar ridge</td><td>1 (4%)</td></tr><tr><td>Palate/maxilla</td><td>1 (4%)</td></tr><tr><td>Sinonasal</td><td>1 (4%)</td></tr><tr><td>Total</td><td>24 (100%)</td></tr></table>
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<table><tr><td> </td><td colspan="2">Overall (males + females)</td><td colspan="2">Males</td><td colspan="2">Females</td></tr><tr><td> </td><td>N cases</td><td>Cost per case (&#8364;)</td><td>N cases</td><td>Cost per case (&#8364;)</td><td>N cases</td><td>Cost per case (&#8364;)</td></tr><tr><td>Admitted patients</td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>Osseous injuries foot</td><td>1,527</td><td>6,088 (1,469)</td><td>969</td><td>4,475 (961)</td><td>558</td><td>8,887 (2,349)</td></tr><tr><td>Ligamentous injuries foot</td><td>36</td><td>2,582 (199)</td><td>22</td><td>2,746 (244)</td><td>14</td><td>2,322 (129)</td></tr><tr><td>Osseous injuries ankle</td><td>8,737</td><td>7,383 (1,620)</td><td>3,931</td><td>5,415 (998)</td><td>4,806</td><td>8,993 (2,128)</td></tr><tr><td>Ligamentous injuries ankle</td><td>2,869</td><td>2,780 (281)</td><td>2,153</td><td>2,586 (251)</td><td>716</td><td>3,364 (373)</td></tr><tr><td>Subtotal</td><td>13,169</td><td>6,217 (1,307)</td><td>7,075</td><td>4,417 (764)</td><td>6,094</td><td>8,306 (1,937)</td></tr><tr><td>Non-admitted patients</td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>Osseous injuries foot</td><td>33,511</td><td>836 (126)</td><td>16,418</td><td>687 (93)</td><td>17,092</td><td>979 (157)</td></tr><tr><td>Ligamentous injuries foot</td><td>5,203</td><td>685 (96)</td><td>2,502</td><td>634 (85)</td><td>2,701</td><td>732 (106)</td></tr><tr><td>Osseous injuries ankle</td><td>15,916</td><td>1,308 (154)</td><td>7,832</td><td>1,110 (129)</td><td>8,084</td><td>1,500 (177)</td></tr><tr><td>Ligamentous injuries ankle</td><td>40,368</td><td>684 (82)</td><td>21,460</td><td>642 (69)</td><td>18,908</td><td>731 (97)</td></tr><tr><td>Subtotal</td><td>94,998</td><td>842 (110)</td><td>48,213</td><td>733 (88)</td><td>46,785</td><td>955 (133)</td></tr><tr><td>All patients</td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>Osseous injuries foot</td><td>35,038</td><td>1,065 (184)</td><td>17,387</td><td>898 (141)</td><td>17,650</td><td>1,229 (226)</td></tr><tr><td>Ligamentous injuries foot</td><td>5,240</td><td>698 (97)</td><td>2,525</td><td>653 (87)</td><td>2,715</td><td>740 (106)</td></tr><tr><td>Osseous injuries ankle</td><td>24,653</td><td>3,461 (673)</td><td>11,763</td><td>2,549 (420)</td><td>12,890</td><td>4,294 (904)</td></tr><tr><td>Ligamentous injuries ankle</td><td>43,237</td><td>823 (92)</td><td>23,613</td><td>819 (86)</td><td>19,624</td><td>827 (107)</td></tr><tr><td>Total</td><td>108,167</td><td>1,496 (255)</td><td>55,288</td><td>1,204 (174)</td><td>52,879</td><td>1,802 (338)</td></tr></table>
bfc101f473770bfc4e33b7dab9ab67a2cf825602c1d77d11bd075a39a1b63064.png
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<table><tr><td>Antigen tested</td><td>May 2010</td><td>November 2010</td><td>May 2011</td><td>November 2011</td><td>Overall</td></tr><tr><td>No individuals</td><td>No = 47</td><td>N = 46</td><td>N = 47</td><td>N = 48</td><td>N = 188</td></tr><tr><td colspan="6">Ag MSP1</td></tr><tr><td> Mean OD [min&#8211;max]</td><td>0.57 [0&#8211;1.93]</td><td>0.62 [0&#8211;1.93]</td><td>0.47 [0&#8211;1.36]</td><td>0.82 [0&#8211;2.25]</td><td>0.52 [0&#8211;2.25]</td></tr><tr><td colspan="6"><i>P. vivax</i></td></tr><tr><td> Mean OD ratio [min&#8211;max]</td><td>2.6 [1&#8211;7.1]</td><td>2.9 [1&#8211;6.4]</td><td>2.2 [1&#8211;4.5]</td><td>3.7 [1&#8211;7.2]</td><td>2.9 [1&#8211;7.2]</td></tr><tr><td> No positive (prevalence)</td><td>40%</td><td>41%</td><td>25%</td><td>31%</td><td>53%</td></tr><tr><td colspan="6">Pf MSP1p19</td></tr><tr><td> Mean OD [min&#8211;max]</td><td>0.11 [0&#8211;0.98]</td><td>0.21 [0&#8211;2.10]</td><td>0.10 [0&#8211;1.19]</td><td>0.30 [0&#8211;2.14]</td><td>0.18 [0&#8211;2.14]</td></tr><tr><td> Mean OD ratio [min&#8211;max]</td><td>2.5 [1&#8211;16.7]</td><td>4.0 [1&#8211;34.7]</td><td>2.3 [1&#8211;20.0]</td><td>5.4 [1&#8211;33.8]</td><td>3.5 [1&#8211;33.8]</td></tr><tr><td> Prevalence</td><td>43%</td><td>38%</td><td>23%</td><td>46%</td><td>61%</td></tr><tr><td colspan="6">Ag SE 07_03</td></tr><tr><td> Mean OD [min&#8211;max]</td><td>0.58 [0&#8211;2.45]</td><td>0.65 [0&#8211;2.41]</td><td>0.48 [0&#8211;2.39]</td><td>0.82 [0&#8211;2.59]</td><td>0.63 [0&#8211;2.59]</td></tr><tr><td> Mean OD ratio [min&#8211;max]</td><td>2.5 [1&#8211;10.5]</td><td>2.8 [1&#8211;10.4]</td><td>2.2 [1&#8211;9.6]</td><td>3.5 [1&#8211;12.3]</td><td>2.8 [1&#8211;12.3]</td></tr><tr><td> No positive (prevalence)</td><td>45%</td><td>37%</td><td>28%</td><td>46%</td><td>63%</td></tr></table>
ec8b9707884d874c14069a36a7697f4664203a9f666909e7227a6b3132b5c5ed.png
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<table><tr><td>Type of study model</td><td>Experimental method [subject (age/weight), treatment dosage, duration of treatment]</td><td>Major activity</td><td>Mechanism of action</td><td>Reference</td></tr><tr><td>In vivo study</td><td>Outbred albino female ICR mice (20&#8211;26 g), yogurt containing DSW, 10.3 g hardness of CaCO<sub>3</sub>/L, 8 weeks</td><td>Increased populations of intestinal lactic acid bacteria.Decreased the activity of serum AST and ALT.Reduced TC, TC to HDL-C ratio, TAG, and HDL-C in serum.</td><td>ND.</td><td>[44]</td></tr><tr><td>In vivo study</td><td>HFD-induced obesity ICR (4 weeks), DSW, and DSW + 125 mg/kg SIE (DSS), ad libitum, treated with SIE once per day for 8 weeks</td><td>Reduced body weights in the DSW group by 3.95% and in the DSS group by 8.42%, respectively.Decreased plasma glucose levels in the DSW group by 14.9% and in the DSS group by 36.4%, respectively.Decreased serum levels of glucose, TAG, and leptin.Decreased insulin resistance index (HOMA-IR) values for the DSS-treated group by 38.2%.</td><td>Decreased size of the epididymal white, retroperitoneal white, and scapular brown adipose tissue.Increased levels of phosphorylated AMPK and its substrate and ACC in mice epididymal adipose tissues.Upregulated the expression levels of lipolysis-associated mRNA, PPAR-<i>&#945;</i>, cluster of differentiation 36 (CD36), and energy expenditure-associated mRNA and UCP2 and CPT1 epididymal adipose tissues.Suppressed the expression of SREBP1 at the mRNA level.</td><td>[45]</td></tr><tr><td>In vivo study</td><td>Green tea leaves were soaked in desalinated DSW at 75&#176;C for 10 min</td><td>Increased antioxidant activity.</td><td>Increased 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activities by 83.98% and increased reducing power by 15%.Increased nitrite scavenging activity from 31.33 &#177; 0.05 to 37.12 &#177; 0.42%.Increased amounts of catechins and caffeine.</td><td>[38]</td></tr></table>
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<table><tr><td>Parameter</td><td>Specification</td><td>Method</td></tr><tr><td>Identity DOTA-NOC</td><td>DOTA-NOC</td><td>Acceptance of raw material</td></tr><tr><td>Content: <sup>68</sup>Ga</td><td>90 &#8211; 110% of the declared <sup>68</sup>Ga radioactivity</td><td>Ionization chamber<sup>a</sup></td></tr><tr><td>Content: DOTA-NOC</td><td>Maximum 50 &#956;g</td><td>Quality by design: pre-filled vials with amount needed together with double check in batch record<sup>a</sup></td></tr><tr><td>Appearance</td><td>Clear, colourless solution</td><td>Visual inspection<sup>a</sup></td></tr><tr><td>pH</td><td>4.0 to 8.0</td><td>pH indicator strip<sup>a</sup></td></tr><tr><td>Ethanol</td><td>Maximum 10% (<i>V</i>/<i>V</i>)/maximum 2.5 g per dose</td><td>Quality by design: risk-based approach eliminated need for routine test</td></tr><tr><td>Sterility</td><td>Sterile; bubble point &gt;3,450 mbar</td><td>Validation of aseptic process together with filter integrity test<sup>a</sup></td></tr><tr><td>Bacterial endotoxins</td><td>Less than 175 IU per dose</td><td>Quality by design: risk-based approach eliminated need for routine test</td></tr><tr><td>Impurity A</td><td>&#8804;3%</td><td>ITLC<sup>a</sup></td></tr><tr><td>Impurity B</td><td>&#8804;2%</td><td>Validated ITLC method to replace HPLC<sup>a</sup></td></tr><tr><td>Impurity C</td><td>&#8804;0.001%</td><td>Ionization chamber; assessed at time of acceptance of generator</td></tr></table>
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<table><tr><td rowspan="2">Chr</td><td colspan="2">Nucleotide polymorphism</td><td colspan="2">Insertion</td><td colspan="2">Deletion</td><td rowspan="2">Total</td></tr><tr><td>SNP</td><td>MNP</td><td>WAB56&#8211;104</td><td>CG 14</td><td>WAB56&#8211;104</td><td>CG 14</td></tr><tr><td>1</td><td>360,381</td><td>11,386</td><td>1972</td><td>20,132</td><td>2804</td><td>24,478</td><td>49,386</td></tr><tr><td>2</td><td>316,206</td><td>10,336</td><td>1564</td><td>17,498</td><td>2320</td><td>21,101</td><td>42,483</td></tr><tr><td>3</td><td>306,733</td><td>9299</td><td>1293</td><td>16,964</td><td>1879</td><td>20,338</td><td>40,474</td></tr><tr><td>4</td><td>270,022</td><td>9601</td><td>1370</td><td>14,362</td><td>2061</td><td>17,316</td><td>35,109</td></tr><tr><td>5</td><td>251,323</td><td>8021</td><td>1377</td><td>13,075</td><td>2055</td><td>15,560</td><td>32,067</td></tr><tr><td>6</td><td>271,081</td><td>9447</td><td>1413</td><td>14,354</td><td>1997</td><td>17,557</td><td>35,321</td></tr><tr><td>7</td><td>254,203</td><td>8756</td><td>899</td><td>14,537</td><td>1314</td><td>17,184</td><td>33,934</td></tr><tr><td>8</td><td>221,116</td><td>7317</td><td>1131</td><td>11,605</td><td>1632</td><td>14,365</td><td>28,733</td></tr><tr><td>9</td><td>190,775</td><td>6350</td><td>666</td><td>10,347</td><td>893</td><td>12,284</td><td>24,190</td></tr><tr><td>10</td><td>201,301</td><td>7146</td><td>1771</td><td>9125</td><td>2600</td><td>11,457</td><td>24,953</td></tr><tr><td>11</td><td>238,964</td><td>8611</td><td>1884</td><td>11,917</td><td>2360</td><td>14,295</td><td>30,456</td></tr><tr><td>12</td><td>203,812</td><td>7230</td><td>1527</td><td>10,421</td><td>2084</td><td>12,631</td><td>26,663</td></tr><tr><td>Un</td><td>538</td><td>9</td><td>3</td><td>20</td><td>5</td><td>32</td><td>60</td></tr><tr><td>Sy</td><td>2363</td><td>59</td><td>7</td><td>113</td><td>2</td><td>119</td><td>241</td></tr><tr><td>Total</td><td>3,088,818</td><td>103,568</td><td>16,877</td><td>164,470</td><td>24,006</td><td>198,717</td><td>404,070</td></tr></table>
8f3ee823f02e58bf5af082086b58aa5fb99a54604a22f4510617454a42a09c7d.png
simple
<table><tr><td>Island</td><td><i>N</i><sub>A</sub></td><td><i>H</i><sub>O</sub></td><td><i>H</i><sub>E</sub></td><td><i>A</i><sub>r</sub></td><td><i>F</i></td><td>HWD</td></tr><tr><td>Floreana</td><td>0.136 (0.152)</td><td>0.281 (0.091)</td><td>0.44 5 (0.081)</td><td>2.273 (0.825)</td><td>0.353 (0.185)</td><td>D11Mgh5, D5Rat83, D16Rat81, D10Rat20, RfgC2</td></tr><tr><td>Baltra</td><td>0.066 (0.068)</td><td>0.383 (0.091)</td><td>0.458 (0.098)</td><td>2.489 (1.047)</td><td>0.153 (0.088)</td><td>D5Rat83, D16Rat81, RfgL1</td></tr><tr><td>Bartolome</td><td>0.092 (0.128)</td><td>0.445 (0.096)</td><td>0.533 (0.043)</td><td>2.406 (0.601)</td><td>0.215 (0.161)</td><td>D5Rat83, RfgL1</td></tr><tr><td>Bainbridge</td><td>0.173 (0.121)</td><td>0.122 (0.048)</td><td>0.339 (0.069)</td><td>1.856 (0.576)</td><td>0.584 (0.150)</td><td>D11Mgh5, D5Rat83, D16Rat81, D10Rat20, D9Rat13, RfgL1, RfgL4</td></tr><tr><td>Bowditches</td><td>0.115 (0.128)</td><td>0.212 (0.064)</td><td>0.348 (0.07)</td><td>1.974 (0.66)</td><td>0.344 (0.157)</td><td>D11Mgh5, D5Rat83, D16Rat81</td></tr><tr><td>Eden</td><td>0.046 (0.111)</td><td>0.280 (0.099)</td><td>0.333 (0.095)</td><td>1.86 (0.795)</td><td>0.119 (0.134)</td><td>D16Rat81, RfgL1</td></tr><tr><td>Isabela</td><td>0.134 (0.068)</td><td>0.314 (0.057)</td><td>0.508 (0.089)</td><td>2.53 (0.967)</td><td>0.384 (0.087)</td><td>D11Mgh5, D5Rat83, D16Rat81, D10Rat20, D9Rat13, RfgL1, RfgD6, RfgL4</td></tr><tr><td>Marielas</td><td>0.013 (0.037)</td><td>0.344 (0.096)</td><td>0.368 (0.09)</td><td>1.885 (0.824)</td><td>0.063 (0.162)</td><td>None</td></tr><tr><td>Pinzon</td><td>0.125 (0.127)</td><td>0.191 (0.075)</td><td>0.348 (0.073)</td><td>1.886 (0.572)</td><td>0.459 (0.153)</td><td>D11Mgh5, D5Rat83, D16Rat81, D10Rat20, RfgL1, RfgL4</td></tr><tr><td>Sombrero Chino</td><td>0.123 (0.122)</td><td>0.355 (0.095)</td><td>0.524 (0.081)</td><td>2.616 (0.902)</td><td>0.350 (0.135)</td><td>D11Mgh5, D5Rat83, D16Rat81, D10Rat20, D9Rat13, RfgL1, RfgL4</td></tr><tr><td>San Cristobal</td><td>0.152 (0.094)</td><td>0.338 (0.071)</td><td>0.581 (0.081)</td><td>2.919 (0.957)</td><td>0.438 (0.072)</td><td>D11Mgh5, D16Rat81, D10Rat20, D9Rat13, RfgL1, RfgL4</td></tr><tr><td>Santa Cruz</td><td>0.129 (0.096)</td><td>0.295 (0.075)</td><td>0.467 (0.086)</td><td>2.368 (0.768)</td><td>0.353 (0.098)</td><td>D11Mgh5, D5Rat83, D16Rat81, D10Rat20, D9Rat13, RfgL1, RfgD6, RfgL4</td></tr><tr><td>North Seymour</td><td>0.081 (0.106)</td><td>0.358 (0.086)</td><td>0.479 (0.099)</td><td>2.525 (0.99)</td><td>0.195 (0.101)</td><td>D5Rat83, D16Rat81, D10Rat20, RfgL1</td></tr><tr><td>Santiago</td><td>0.129 (0.122)</td><td>0.288 (0.075)</td><td>0.477 (0.09)</td><td>2.492 (0.965)</td><td>0.364 (0.122)</td><td>D11Mgh5, D5Rat83, D16Rat81, D10Rat20, RfgL1</td></tr><tr><td>Venecia</td><td>0.114 (0.129)</td><td>0.231 (0.089)</td><td>0.380 (0.096)</td><td>2.081 (0.877)</td><td>0.497 (0.153)</td><td>D11Mgh5, D5Rat83, D16Rat81, RfgL1, RfgL4</td></tr><tr><td>Total</td><td>0.108 (0.113)</td><td>0.296 (0.021)</td><td>0.439 (0.022)</td><td>3.247 (1.05)</td><td>0.328 (0.035)</td><td>All loci, all populations <i>P</i> &lt; 0.001</td></tr></table>
4eb7cad8b7042576a29cdd5b2b4b0de1b4bfe986fd36ee6a28f8ad72948f6298.png
complex
<table><tr><td></td><td>LDL-C reduction &lt;50% (<i>n</i> = 242)</td><td>LDL-C reduction &#8805;50% (<i>n</i> = 151)</td><td><i>p</i>-value</td></tr><tr><td>Female</td><td>152 (62.8%)</td><td>99 (65.6%)</td><td>0.58</td></tr><tr><td>Age (years)</td><td>63.2 &#177; 13</td><td>66.4 &#177; 12.1</td><td><i>0.02</i></td></tr><tr><td>Duration of DM (mo, median)</td><td>13</td><td>13</td><td>0.29</td></tr><tr><td>Duration of statin usage (mo, median)</td><td>56</td><td>88</td><td><i>&lt;0.01</i></td></tr><tr><td>Smoking</td><td>7/215 (3.3%)</td><td>3/133 (2.3%)</td><td>0.86</td></tr><tr><td>Alcohol</td><td>17/213 (8.0%)</td><td>10/132 (7.6%)</td><td>0.89</td></tr><tr><td>Family history of CHD</td><td>1/112 (0.9%)</td><td>4/72 (5.6%)</td><td>0.08</td></tr><tr><td>Body mass index (kg/m<sup>2</sup>)</td><td>26.2 &#177; 4.9</td><td>26.6 &#177; 6.8</td><td>0.58</td></tr><tr><td>Weight before statin treatment (kg)</td><td>65.9 &#177; 12.6</td><td>67.4 &#177; 13.9</td><td>0.28</td></tr><tr><td>Waist circumference (cm)</td><td>94.6 &#177; 11.9</td><td>91.2 &#177; 10.4</td><td>0.19</td></tr><tr><td>Weight reduction</td><td>87/227 (38.3%)</td><td>68/138 (49.3%)</td><td><i>0.04</i></td></tr><tr><td>SBP (mmHg)</td><td>131.8 &#177; 14.3</td><td>74.9 &#177; 11.3</td><td>0.11</td></tr><tr><td>DBP (mmHg)</td><td>74.9 &#177; 11.3</td><td>73.8 &#177; 10.8</td><td>0.33</td></tr><tr><td colspan="4">Comorbidities</td></tr><tr><td> CHD</td><td>35/242 (14.5%)</td><td>20/151 (13.2%)</td><td>0.74</td></tr><tr><td> Stroke</td><td>18/242 (7.4%)</td><td>9/151 (6.0%)</td><td>0.57</td></tr><tr><td> Peripheral artery disease</td><td>6/242 (2.5%)</td><td>5/151 (3.3%)</td><td>0.63</td></tr><tr><td> Aortic aneurysm</td><td>2/242 (0.8%)</td><td>0/151 (0.0%)</td><td>0.26</td></tr><tr><td> Hypertension</td><td>167/242 (69.0%)</td><td>124/151 (82.0%)</td><td><i>&lt;0.01</i></td></tr><tr><td> Chronic kidney disease</td><td>65/242 (26.9%)</td><td>40/151 (26.5%)</td><td>0.94</td></tr><tr><td>Diabetic retinopathy</td><td></td><td></td><td>0.79</td></tr><tr><td> Normal</td><td>135/206 (65.5%)</td><td>94/136 (69.1%)</td><td></td></tr><tr><td> NPDR</td><td>51/206 (24.8%)</td><td>30/136 (22.1%)</td><td></td></tr><tr><td> PDR</td><td>20/206 (9.7%)</td><td>12/136 (8.8%)</td><td></td></tr><tr><td>Diabetic neuropathy</td><td></td><td></td><td>0.75</td></tr><tr><td> Normal</td><td>75/105 (71.4%)</td><td>43/58 (74.1%)</td><td></td></tr><tr><td> Impaired Monofilament</td><td>21/105 (20.0%)</td><td>9/58 (15.5%)</td><td></td></tr><tr><td> Foot ulcer</td><td>9/105 (8.6%)</td><td>6/58 (10.4%)</td><td></td></tr><tr><td>Diabetic nephropathy</td><td></td><td></td><td>0.93</td></tr><tr><td> MAU &#8805; 30 mg/g creatinine</td><td>71/175 (40.6%)</td><td>48/117 (41.0%)</td><td></td></tr><tr><td> MAU &lt; 30 mg/g creatinine</td><td>104/175 (59.4%)</td><td>69/117 (59.0%)</td><td></td></tr><tr><td>Statin potency</td><td></td><td></td><td>0.19</td></tr><tr><td> Low-intensity statin users</td><td>106/242 (43.8%)</td><td>56/151 (37.1%)</td><td></td></tr><tr><td> Moderate-intensity statin users</td><td>136/242 (56.2%)</td><td>95/151 (62.9%)</td><td></td></tr><tr><td colspan="4">Pre-statin blood chemistry</td></tr><tr><td> Total cholesterol (mg/dl)</td><td>204.7 &#177; 43.8</td><td>242.4 &#177; 39.1</td><td><i>&lt;0.01</i></td></tr><tr><td> Triglyceride (mg/dl)</td><td>153.5 &#177; 81.0</td><td>161.8 &#177; 74.6</td><td>0.35</td></tr><tr><td> HDL (mg/dl)</td><td>50.9 &#177; 16.3</td><td>51.1 &#177; 13.1</td><td>0.95</td></tr><tr><td> LDL-C (mg/dl)</td><td>125.7 &#177; 34.1</td><td>160.0 &#177; 33.2</td><td><i>&lt;0.01</i></td></tr><tr><td> HbA1C (%)</td><td>8.3 &#177; 2.0</td><td>7.7 &#177; 1.6</td><td><i>&lt;0.01</i></td></tr><tr><td> FBS (mg/dl, median)</td><td>158.9</td><td>169.4</td><td>0.32</td></tr></table>
2606aa2c4077168f1f85a3435caefe557860515366c1c89c111a61551163209c.png
simple
<table><tr><td>Parameter name</td><td>Percent of losses</td></tr><tr><td>Total amount of Cdc14</td><td>3.14</td></tr><tr><td>SPN synthesis rate</td><td>2.81</td></tr><tr><td>Total amount of Esp1</td><td>2.60</td></tr><tr><td>Total amount of Net1</td><td>2.57</td></tr><tr><td>Degradation rate of Cdc20</td><td>2.53</td></tr><tr><td>PPX inactivation by Esp1</td><td>2.51</td></tr><tr><td>Efficiency of Cdc14-Net1 complex (RENT) formation</td><td>2.50</td></tr><tr><td>Time scale for protein activation</td><td>2.41</td></tr><tr><td>Net1 phosphorylation by Clb2</td><td>2.30</td></tr><tr><td>Total amount of Mcm1</td><td>2.25</td></tr><tr><td>Transcriptional activation of <i>CDC20</i> by Mcm1</td><td>2.17</td></tr><tr><td>Transcriptional activation of <i>CLB2</i> by Mcm1</td><td>2.06</td></tr><tr><td>Sigmoidicity of protein activation</td><td>1.99</td></tr><tr><td>Degradation rate of Swi5</td><td>1.99</td></tr><tr><td>CKI phosphorylation rate</td><td>1.96</td></tr><tr><td>Cdh1 inactivation rate</td><td>1.83</td></tr><tr><td>Total amount of SBF</td><td>1.79</td></tr><tr><td>Clb2 degradation by active Cdc20</td><td>1.76</td></tr><tr><td>Polo activation by Clb2</td><td>1.67</td></tr><tr><td>Synthesis rate of Bck2</td><td>1.66</td></tr></table>
741cf4a3ed8c574c1f32d1e8dfd1c4b7b368d0f05b842afb1ba91183c01a18c2.png
simple
<table><tr><td>No. genes</td><td>DQDA</td><td>DLDA</td><td>1NN</td><td>Tree</td><td>SVM</td><td>MPCLR</td><td>MLDA</td></tr><tr><td>5</td><td>0.113</td><td>0.113</td><td>0.210</td><td>0.226</td><td>0.113</td><td>0.097</td><td>0.097</td></tr><tr><td>10</td><td>0.177</td><td>0.177</td><td>0.161</td><td>0.290</td><td>0.129</td><td>0.097</td><td>0.129</td></tr><tr><td>15</td><td>0.113</td><td>0.129</td><td>0.129</td><td>0.242</td><td>0.145</td><td>0.113</td><td>0.113</td></tr><tr><td>20</td><td>0.145</td><td>0.129</td><td>0.161</td><td>0.258</td><td>0.129</td><td>0.113</td><td>0.129</td></tr><tr><td>30</td><td>0.145</td><td>0.129</td><td>0.161</td><td>0.194</td><td>0.145</td><td>0.129</td><td>0.113</td></tr><tr><td>40</td><td>0.145</td><td>0.129</td><td>0.145</td><td>0.210</td><td>0.145</td><td>0.129</td><td>0.129</td></tr><tr><td>50</td><td>0.145</td><td>0.145</td><td>0.194</td><td>0.226</td><td>0.145</td><td>0.145</td><td>0.113</td></tr></table>
25e37ce5128b786d15790561ccd6ef5ac4a4815de60f4e7a90688e3d1c85658a.png
simple
<table><tr><td></td><td>PM&#8211;AM</td><td>PM/AM</td></tr><tr><td>Anterior wall of the left ventricle</td><td>0.21</td><td>0.18</td></tr><tr><td>Left ventricular free wall</td><td>0.11</td><td>0.11</td></tr><tr><td>Posterior wall of the left ventricle</td><td>0.10</td><td>0.067</td></tr><tr><td>Ventricular septum</td><td>0.16</td><td>0.10</td></tr><tr><td>Right ventricular wall</td><td>0.15</td><td>0.04</td></tr></table>
65b3744f7af9b92f363498ac8852a2a15af8bf94749fa48db79ce47872388ba3.png
complex
<table><tr><td>Characteristic</td><td>Full cohort (n = 10,004)</td><td>Survey responders (n = 635)</td><td>p value</td></tr><tr><td>Mean age (SD), yr</td><td>8.0 (3.8)</td><td>8.1 (3.8)</td><td>0.35</td></tr><tr><td>Age 0-2 yr, n (%)</td><td>806 (8.1%)</td><td>51 (8.0%)</td><td></td></tr><tr><td>Age 3-5 yr, n (%)</td><td>2155 (21.5%)</td><td>143 (22.5%)</td><td></td></tr><tr><td>Age 6-8 yr, n (%)</td><td>2307 (23.1%)</td><td>126 (19.8%)</td><td></td></tr><tr><td>Age 9-11 yr, n (%)</td><td>2402 (24.0%)</td><td>165 (26.0%)</td><td></td></tr><tr><td>Age 12-14 yr, n (%)</td><td>2334 (23.3%)</td><td>150 (23.6%)</td><td></td></tr><tr><td>Male sex, n (%)</td><td>5942 (59.4%)</td><td>365 (57.5%)</td><td>0.29</td></tr><tr><td>Smoking status</td><td></td><td></td><td>0.22</td></tr><tr><td>Non smoker</td><td>5651 (56.5%)</td><td>366 (57.6%)</td><td></td></tr><tr><td>Smoker</td><td>532 (5.3%)</td><td>31 (4.9%)</td><td></td></tr><tr><td>Ex smoker</td><td>77 (0.8%)</td><td>6 (0.9%)</td><td></td></tr><tr><td>Passive smoker</td><td>152 (1.5%)</td><td>3 (0.5%)</td><td></td></tr><tr><td>Unknown smoking status</td><td>3592 (35.9%)</td><td>229 (36.1%)</td><td></td></tr><tr><td>BMI, n</td><td>5816</td><td>393</td><td></td></tr><tr><td>Mean BMI (SD)</td><td>17.3 (5.3)</td><td>17.1 (5.0)</td><td>0.32</td></tr><tr><td>Median BMI (range)</td><td>16.6 (5.0-49.6)</td><td>16.7 (5.2-47.7)</td><td>0.75</td></tr><tr><td>Asthma duration: mean (SD), yr</td><td>4.3 (3.6)</td><td>4.4 (3.6)</td><td>0.56</td></tr><tr><td>Median (range), yr</td><td>3.7 (0.0-15.0)</td><td>3.9 (0.0-14.0)</td><td>0.62</td></tr><tr><td colspan="3">Asthma controller therapy prescription at index date, n (%)</td><td>0.437</td></tr><tr><td>ICS monotherapy</td><td>9059 (90.6%)</td><td>575 (90.6%)</td><td></td></tr><tr><td>LABA in fixed dose combination</td><td>574 (5.7%)</td><td>43 (6.8%)</td><td></td></tr><tr><td>ICS + LABA</td><td>124 (1.2%)</td><td>4 (0.6%)</td><td></td></tr><tr><td>LTRA monotherapy</td><td>91 (0.9%)</td><td>6 (0.9%)</td><td></td></tr><tr><td>ICS + LTRA</td><td>55 (0.6%)</td><td>1 (0.2%)</td><td></td></tr><tr><td>Other</td><td>101 (1.0%)</td><td>6 (0.9%)</td><td></td></tr></table>
e7c9d0f4c72dcc12ec26bab2c621c5a4a8202b62b5b4ce14651f1016201d9a3c.png
simple
<table><tr><td>Profile</td><td>WD (m)</td><td><i>V</i><sub>p</sub> (m/s)</td><td>HF (mW/m<sup>2</sup>)</td></tr><tr><td>KR9904-7</td><td>4472</td><td>1700</td><td>108</td></tr><tr><td></td><td></td><td>1800</td><td>102</td></tr><tr><td></td><td></td><td>1900</td><td>97</td></tr><tr><td>KR9904-8</td><td>765</td><td>1450 (in seawater)</td><td>38</td></tr><tr><td></td><td>792</td><td>1500 (in seawater)</td><td>40</td></tr><tr><td></td><td>818</td><td>1550 (in seawater)</td><td>41</td></tr></table>
43f5ecc08bf73d5c546749888fe8ea11043a1254e4a8c329a16611c92ade8053.png
complex
<table><tr><td rowspan="2">Item</td><td colspan="3">Baseline (N = 153)</td><td colspan="3">End-line (N = 149)</td></tr><tr><td>never/rarely</td><td>some-times</td><td>usually/always</td><td>never/rarely</td><td>some-times</td><td>usually/always</td></tr><tr><td>Helps me if the problem is affecting how well I do my job</td><td>17 (11.1%)</td><td>22 (14.4%)</td><td>114 (74.5%)</td><td>9 (6%)</td><td>12 (8.1%)</td><td>128 (85.9%)</td></tr><tr><td>Listens to me and encourages me to solve my problem</td><td>20 (13.1%)</td><td>14 (9.2%)</td><td>119 (77.8%)</td><td>7 (4.7%)</td><td>8 (5.4%)</td><td>134 (89.9%)</td></tr><tr><td>Puts me in touch with a service that can help me, if this is what I need</td><td>34 (22.2%)</td><td>19 (12.4%)</td><td>100 (65.4%)</td><td>7 (4.7%)</td><td>16 (10.7%)</td><td>126 (84.6%)</td></tr></table>
e3acb5a10acbfffb289b47558aa708a976977e6075805f51430014f700411383.png
complex
<table><tr><td>Category</td><td colspan="4">Predefined criteria</td></tr><tr><td>Non-activated neutrophil</td><td>intact cell</td><td>lobulated nucleus</td><td>positive NE staining in cytoplasmic granulae only</td><td></td></tr><tr><td>Activated/NET-forming neutrophil</td><td>intact cell</td><td>altered nuclear morphology</td><td>positive NE staining in cytoplasm and/or nucleus</td><td></td></tr><tr><td>Large amounts of NETs</td><td>extracellular fibrous structures</td><td>positive PI-staining</td><td>positive NE staining</td><td>extended, confluent and/or overlapping formations occupying at least 1 mm<sup>2</sup></td></tr><tr><td>Minor traces of NETs</td><td>extracellular fibrous structures</td><td>positive PI-staining</td><td>positive NE staining</td><td>&#8804;10 small-sized (&#8804;50 &#956;m<sup>2</sup>) nonoverlapping items per 100 mm<sup>2</sup></td></tr></table>
baf195101aeed9f9c62b68ddc5dad6f4a25b3637ab8b4992f5ad026a69a2f228.png
simple
<table><tr><td>Reference</td><td>PrP source</td><td>PK</td><td>Denaturation</td><td>Antibodies</td><td>Detection method</td><td>Sensitivity*</td></tr><tr><td>[30]</td><td>rMoPrP, rOvPrP, rBoPrP, rHuPrP, and mice brain</td><td>&#8722;</td><td>&#8722;</td><td>C: 11G5D: 11G5-biotin</td><td>Sandwich ELISA</td><td>6 ng of aggregated PrP</td></tr><tr><td>[13]</td><td>BSE bovine brain and scrapie ovine brain</td><td>+</td><td>&#8722;</td><td>C: 6H4D: n.r.</td><td>Sandwich ELISA</td><td>6 pg rPrP/well30 pg/mL</td></tr><tr><td>[33]</td><td>Scrapie sheep brain and tonsils, BSE bovine brain, and scrapie hamster brain</td><td>+</td><td>&#8722;</td><td>D: SAF70Secondary AB conjugated with peroxidase</td><td>ELISA</td><td>3 ng rBoPrP</td></tr><tr><td>[41]</td><td>sCJD human brain</td><td>+</td><td>&#8722;</td><td>C: 1E5D: 4F7-biotinStreptavidin-biotin-DNA</td><td>IPCR</td><td>n.r.</td></tr><tr><td>[42]</td><td>Scrapie hamster brain</td><td>+</td><td>&#8722;</td><td>C: 8b4 or 7A12D: 3F4-biotinStreptavidin-biotin-DNA</td><td>IPCR</td><td>1 &#215; 104 PrP<sup>Sc</sup> molecules/mLor 19 fg/mL</td></tr><tr><td>[22]</td><td>BSE bovine brain</td><td>&#8722;</td><td>0.1 M GdnSCN</td><td>C: 6H4D: rabbit antiserum C15SSwine anti-rabbit Ab-HRP</td><td>Sandwich ELISA</td><td>1 ug PrP<sup>Sc</sup>/mL</td></tr><tr><td>[26]</td><td>BSE bovine brain</td><td>&#8722;</td><td>1 M GdnHCl6 M GdnHCl</td><td>C: FH11D: 3F4-Eu</td><td>DELFIA</td><td>36 pg PrP/well</td></tr><tr><td>[23]</td><td>BSE bovine brain, CWD white-tailed deer, mule deer, and elk brains</td><td>+</td><td>4 M GdnHCl</td><td>C: Fab D18D: recFab HuM-P-Eu</td><td>DELFIA</td><td>1 ng rec <i>&#946;</i>-MBo2M PrP/mL</td></tr><tr><td>[27]</td><td>Scrapie mouse and hamster brain</td><td>&#8722;</td><td>8 M GdnHCl6 M GdnHCl</td><td>C: 11G5D: 7A12, 2F8, 8F9, and 8B4-biotin</td><td>Sandwich ELISA</td><td>0.05&#8211;5 ng rHuPrP</td></tr><tr><td>[24]</td><td>Scrapie sheep brain</td><td>&#8722;</td><td>6 M GdnHCl</td><td>C: FH11D: 8H4-Eu</td><td>DELFIA</td><td>200 pg rOvPrP/well</td></tr><tr><td>[28]</td><td>vCJD human spleen and brain</td><td>&#8722;</td><td>2 M GdnHCl6 M GdnHCL</td><td>C: FH11D: 3F4-Eu</td><td>DELFIA</td><td>10 pg rHuPrP/mL</td></tr><tr><td>[20]</td><td>BSE ovine brain and scrapie ovine brain</td><td>+</td><td>Heath </td><td>C: SAF34D: Bar224-enzyme</td><td>Sandwich ELISA</td><td>n.r.</td></tr><tr><td>[39]</td><td>Scrapie hamster and sheep brain, CWD-infected white-tailed deer brain</td><td>&#8722;</td><td>1% SDS</td><td>C: 11F12D: 5D6-biotinStreptavidin-Rhodamine Red X</td><td>SOFIA</td><td>10 ag rHaPrP, rMoPrP, rOvPrP, and rDePr</td></tr><tr><td>[25]</td><td>TME hamster brain</td><td>+</td><td>3 M GdnSCN</td><td>D: 3F4Goat anti-mouse-HRP</td><td>ELISA</td><td>n.r.</td></tr><tr><td>[37]</td><td>Paraffin-embedded scrapie ship, CWD white-tailed deer and TME cattle brains</td><td>&#8722;</td><td>Denaturation buffer (not specified)</td><td>HerdChek BSE-Scrapie Ag TestC: polyanionic ligandD: anti-PrP-HRP</td><td>ELISA</td><td>n.r.</td></tr><tr><td>[29]</td><td>CJD human brain</td><td>&#8722;</td><td>3 M GdnSCN</td><td>C: V5B2D: EM20</td><td>DELFIA</td><td>n.r.</td></tr></table>
e70c41a4c570f960bdc7e656556a59ed6b16134daf8ffdc1a7c58b103eff8962.png
complex
<table><tr><td>Origin</td><td><i>pfcrt</i></td><td><i>pfmdr1</i></td><td></td><td colspan="3"><i>Pfdhfr</i></td><td colspan="2"><i>Pfdhps</i></td><td>Number (Proportion %)</td></tr><tr><td></td><td>76</td><td>86</td><td>Copy Number</td><td>51</td><td>59</td><td>108</td><td>437</td><td>540</td><td></td></tr><tr><td>Honduras</td><td>K</td><td>N</td><td>1</td><td>N</td><td>C</td><td>S</td><td>A</td><td>K</td><td>30 (94)<sup>&#167;</sup></td></tr><tr><td>Pacific</td><td>T</td><td>Y</td><td>1</td><td>I</td><td>R</td><td>N</td><td>A</td><td>K</td><td>1 (3)</td></tr><tr><td>Africa</td><td>K</td><td>Y</td><td>1</td><td>I</td><td>R</td><td>N</td><td>G/A</td><td>K</td><td>1 (3)</td></tr></table>
124c41f119af15a20671419512bd88ed6573de48c36f32cdb4a8538b314472f3.png
complex
<table><tr><td></td><td></td><td></td><td colspan="3">Months post treatment</td></tr><tr><td>UFS-QoL parameter</td><td>Statistic</td><td>Screening(<i>N</i> = 107)</td><td>1(<i>N</i> = 107)</td><td>3(<i>N</i> = 102)</td><td>6(<i>N</i> = 100)</td></tr><tr><td colspan="6">SSS transformed<sup>a</sup></td></tr><tr><td></td><td>Mean (SD)</td><td>34.4 (14.70)</td><td>28.1 (15.00)</td><td>27.2 (15.70)</td><td>24 (16.10)</td></tr><tr><td></td><td>95 % CI</td><td>(31.6, 37.2)</td><td>(25.2, 30.9)</td><td>(24.2, 30.3)</td><td>(20.8, 27.2)</td></tr><tr><td colspan="6">HRQL transformed<sup>a</sup></td></tr><tr><td></td><td>Mean (SD)</td><td>73 (18.80)</td><td>78.1 (18.00)</td><td>78.5 (19.50)</td><td>82.2 (17.30)</td></tr><tr><td></td><td>95 % CI</td><td>(69.4, 76.6)</td><td>(74.7, 81.6)</td><td>(74.7, 82.4)</td><td>(78.7, 85.6)</td></tr><tr><td colspan="6">Total score</td></tr><tr><td></td><td>Mean (SD)</td><td>79.3 (25.10)</td><td>71.3 (24.40)</td><td>70.6 (26.10)</td><td>65.4 (24.30)</td></tr><tr><td></td><td>95 % CI</td><td>(74.5, 84.1)</td><td>(66.7, 76)</td><td>(65.5, 75.7)</td><td>(60.5, 70.2)</td></tr></table>
297d206df689a9b9af978fe48d89ae6506194756c99a3279777fd627d0c7acbb.png
simple
<table><tr><td>Sample subset</td><td>Predicted category</td><td><i>N</i></td><td>Estimated error &#177; SD</td><td>Baseline error</td><td>Ratio</td></tr><tr><td>All phone samples</td><td>Person</td><td>104</td><td>0.037 &#177; 0.062</td><td>0.500</td><td>13.63</td></tr><tr><td>All shoe samples</td><td>Person</td><td>211</td><td>0.010 &#177; 0.020</td><td>0.479</td><td>50.26</td></tr><tr><td>P1 phone samples</td><td>Front/back</td><td>52</td><td>0.417 &#177; 0.206</td><td>0.481</td><td>1.15</td></tr><tr><td>P2 phone samples</td><td>Front/back</td><td>52</td><td>0.268 &#177; 0.180</td><td>0.481</td><td>1.79</td></tr><tr><td>P1 shoe samples</td><td>Shoe surface</td><td>110</td><td>0.705 &#177; 0.125</td><td>0.736</td><td>1.05</td></tr><tr><td>P2 shoe samples</td><td>Shoe surface</td><td>101</td><td>0.796 &#177; 0.090</td><td>0.732</td><td>0.92</td></tr></table>
cc8518eedabc5f5b2fd560fd5dfabd7cdc58f4e43e6d1fee57958e1e9e013ec7.png
simple
<table><tr><td>Plasmid pools</td><td>Infected/inoculated <i>C. quinoa </i>plants<sup>a</sup></td><td>Infectious plasmids per pool</td></tr><tr><td>T7-cDNA Pool 1</td><td>0/10</td><td>0</td></tr><tr><td>T7-cDNA Pool 2</td><td>0/26</td><td>0</td></tr><tr><td>T7-cDNA Pool 3</td><td>10/16</td><td>1</td></tr><tr><td>T7-cDNA Pool 4</td><td>0/26</td><td>0</td></tr><tr><td>70S-cDNA Pool 1</td><td>5/6</td><td>1</td></tr><tr><td>70S-cDNA Pool 2</td><td>4/6</td><td>1</td></tr><tr><td>70S-cDNA Pool 3</td><td>0/12</td><td>0</td></tr></table>
80833cbf5d95a35cc823c236bbf618b28a211f18fb96b172dc7390b8814a3962.png
simple
<table><tr><td>Classifier algorithms</td><td>TP rate/Recall</td><td>FP rate</td><td>Accuracy</td><td>Precision</td><td>F-measure</td><td>MCC</td></tr><tr><td>Bayes Net</td><td>0.662</td><td>0.214</td><td>0.782</td><td>0.076</td><td>0.136</td><td>0.169</td></tr><tr><td>Decision Table</td><td>0.268</td><td>0.243</td><td>0.744</td><td>0.028</td><td>0.051</td><td>0.009</td></tr><tr><td>DTNB</td><td>0.296</td><td>0.205</td><td>0.781</td><td>0.037</td><td>0.065</td><td>0.035</td></tr><tr><td>Functional Tree</td><td>0.648</td><td>0.253</td><td>0.744</td><td>0.063</td><td>0.115</td><td>0.141</td></tr><tr><td>J48</td><td>0.620</td><td>0.211</td><td>0.784</td><td>0.072</td><td>0.129</td><td>0.155</td></tr><tr><td>Logistic Regression</td><td>0.690</td><td>0.20</td><td>0.797</td><td>0.084</td><td>0.149</td><td>0.190</td></tr><tr><td>LWL (J48 + KNN)</td><td>0.676</td><td>0.213</td><td>0.783</td><td>0.077</td><td>0.139</td><td>0.175</td></tr><tr><td>Naive Bayes</td><td>0.718</td><td>0.199</td><td>0.799</td><td>0.087</td><td>0.156</td><td>0.201</td></tr><tr><td>NB Tree</td><td>0.493</td><td>0.229</td><td>0.764</td><td>0.054</td><td>0.097</td><td>0.098</td></tr><tr><td>Random Forest</td><td>0.592</td><td>0.196</td><td>0.798</td><td>0.074</td><td>0.131</td><td>0.154</td></tr><tr><td>SVM</td><td>0.788</td><td>0.233</td><td>0.767</td><td>0.082</td><td>0.148</td><td>0.203</td></tr></table>
af56af5e452b0644d532091f295e7c895db5c5d4e0b73735ba4a461859b8962c.png
complex
<table><tr><td>Genotypic combination</td><td>Cases<i>n</i> (%)</td><td>Controls<i>n</i> (%)</td><td><i>&#967;</i><sup>2</sup> (<i>P</i> value)<sup>a</sup></td><td><i>&#967;</i><sup>2</sup> (<i>P</i> value)<sup>b</sup></td></tr><tr><td colspan="5"><i>GSTM1/GSTT1</i>:</td></tr><tr><td>+,+/+,+</td><td>36 (34.6)</td><td>112 (53.8)</td><td>10.2 (0.001)</td><td> </td></tr><tr><td>&#8722;,&#8722;/+,+</td><td>56 (53.8)</td><td>80 (38.5)</td><td>6.6 (0.01)</td><td>10.3 (0.006)</td></tr><tr><td>+,+/&#8722;,&#8722;</td><td>12 (11.5)</td><td>16 (7.7)</td><td>1.2 (0.3)</td><td> </td></tr><tr><td>&#8722;,&#8722;/&#8722;,&#8722;</td><td>0 (0.0)</td><td>0 (0.0)</td><td> NA</td><td>NA</td></tr><tr><td colspan="5"><i>rs4646903 T&gt;C/ rs1048943 A&gt;G</i>:</td></tr><tr><td>TT/AA</td><td>72 (69.2)</td><td>120 (57.7)</td><td>3.9 (0.04)</td><td> </td></tr><tr><td>TC/AG</td><td>8 (7.7)</td><td>24 (11.5)</td><td>1.1 (0.3)</td><td> </td></tr><tr><td>TC/AA</td><td>20 (19.2)</td><td>64 (30.8)</td><td>4.7 (0.03)</td><td>13.9 (0.003)</td></tr><tr><td>CC/GG</td><td>4 (3.8)</td><td>0 (0.0)</td><td>4.0 (0.047)</td><td> </td></tr><tr><td colspan="5"><i>rs1801133 C&gt;T/ rs1801394 A&gt;G</i>:</td></tr><tr><td>CC/AA</td><td>0 (0.0)</td><td>8 (3.8)</td><td>4.2 (0.04)</td><td> </td></tr><tr><td>CC/AG</td><td>56 (53.8)</td><td>120 (57.7)</td><td>0.4 (0.5)</td><td> </td></tr><tr><td>CC/GG</td><td>20 (19.2)</td><td>32 (15.4)</td><td>0.7 (0.4)</td><td> </td></tr><tr><td>CT/AA</td><td>0 (0.0)</td><td>8 (3.8)</td><td>4.2 (0.04)</td><td>20.4 (0.0004)</td></tr><tr><td>CT/AG</td><td>20 (19.2)</td><td>40 (19.2)</td><td>0.0 (1.0)</td><td> </td></tr><tr><td>CT/GG</td><td>8 (7.7)</td><td>0 (0.0)</td><td>8.3 (0.0001)</td><td> </td></tr></table>
f57fca021d02e6da468412bcf99b607aaaaeff74b9d9c5eec1c631efc31dd4b8.png
simple
<table><tr><td>KEGG level 2 pathway</td><td>Day 0</td><td>Day 2</td><td>Day 7</td><td>Day 14</td></tr><tr><td>Amino acid metabolism</td><td>10.03 &#177; 0.75A</td><td>9.99 &#177; 0.54A</td><td>9.80 &#177; 0.63AB</td><td>8.94 &#177; 1.22B</td></tr><tr><td>Biosynthesis of other secondary metabolites</td><td>0.74 &#177; 0.13AB</td><td>0.79 &#177; 0.09A</td><td>0.78 &#177; 0.11AB</td><td>0.66 &#177; 0.13B</td></tr><tr><td>Cell motility</td><td>2.00 &#177; 0.62A</td><td>1.92 &#177; 0.37AB</td><td>1.74 &#177; 0.39AB</td><td>1.41 &#177; 0.56B</td></tr><tr><td>Cellular processes and signaling</td><td>3.70 &#177; 0.54A</td><td>3.58 &#177; 0.37AB</td><td>3.62 &#177; 0.5A</td><td>3.01 &#177; 0.77B</td></tr><tr><td>Energy metabolism</td><td>5.95 &#177; 0.24AB</td><td>5.82 &#177; 0.2A</td><td>5.89 &#177; 0.2A</td><td>6.17 &#177; 0.34B</td></tr><tr><td>Genetic information processing</td><td>2.68 &#177; 0.13A</td><td>2.73 &#177; 0.11AB</td><td>2.79 &#177; 0.1AB</td><td>2.88 &#177; 0.2B</td></tr><tr><td>Metabolism</td><td>2.37 &#177; 0.12A</td><td>2.32 &#177; 0.13AB</td><td>2.29 &#177; 0.12AB</td><td>2.19 &#177; 0.21B</td></tr><tr><td>Metabolism of other amino acids</td><td>1.71 &#177; 0.12A</td><td>1.61 &#177; 0.07B</td><td>1.54 &#177; 0.09B</td><td>1.58 &#177; 0.09B</td></tr><tr><td>Metabolism of terpenoids and polyketides</td><td>1.82 &#177; 0.32A</td><td>1.8 &#177; 0.24A</td><td>1.7 &#177; 0.25AB</td><td>1.41 &#177; 0.47B</td></tr><tr><td>Nucleotide metabolism</td><td>4.15 &#177; 0.34A</td><td>4.31 &#177; 0.36AB</td><td>4.4 &#177; 0.33AB</td><td>4.67 &#177; 0.5B</td></tr><tr><td>Replication and repair</td><td>9.24 &#177; 1.05A</td><td>9.24 &#177; 0.9A</td><td>9.6 &#177; 1.04A</td><td>11.01 &#177; 1.85B</td></tr><tr><td>Signal transduction</td><td>1.61 &#177; 0.23A</td><td>1.54 &#177; 0.16A</td><td>1.44 &#177; 0.18AB</td><td>1.23 &#177; 0.36B</td></tr><tr><td>Transcription</td><td>2.46 &#177; 0.17A</td><td>2.71 &#177; 0.14B</td><td>2.7 &#177; 0.23B</td><td>2.44 &#177; 0.17A</td></tr><tr><td>Translation</td><td>6.61 &#177; 1.3A</td><td>6.61 &#177; 1.37A</td><td>6.96 &#177; 1.39A</td><td>8.88 &#177; 2.54B</td></tr><tr><td>Xenobiotics biodegradation and metabolism</td><td>2.61 &#177; 0.32A</td><td>2.39 &#177; 0.26AB</td><td>2.12 &#177; 0.24B</td><td>2.07 &#177; 0.48B</td></tr></table>
11c328c0a9b5f5dc10907cc631c12956cf26cc70dfdddad4841260b04b62ecb1.png
complex
<table><tr><td> </td><td> </td><td> </td><td colspan="2">Never smoked</td><td colspan="2">Former smoker</td><td colspan="2">Current smoker</td><td colspan="2">Ever smoker</td></tr><tr><td>Region</td><td>Country<sup>b</sup></td><td>Study<sup>c</sup></td><td>Rate</td><td>Weight</td><td>Rate</td><td>Weight</td><td>Rate</td><td>Weight</td><td>Rate</td><td>Weight</td></tr><tr><td>Canada</td><td> </td><td>JAIN</td><td>10.6</td><td>22.6</td><td>16.6</td><td>14.9</td><td>65.9</td><td>44.5</td><td>41.5</td><td>68.4</td></tr><tr><td>USA</td><td> </td><td>ANDERS</td><td>31.4</td><td>36.8</td><td> </td><td> </td><td> </td><td> </td><td>191.4</td><td>143.6</td></tr><tr><td> </td><td> </td><td>BROWN2</td><td>18.9</td><td>413.3</td><td>132.1</td><td>336.8</td><td>132.1</td><td>336.8</td><td>130.7</td><td>748.8</td></tr><tr><td> </td><td> </td><td>BUFFLE</td><td>9.8</td><td>20.0</td><td>32.7</td><td>17.5</td><td>46.7</td><td>61.6</td><td>39.6</td><td>130.4</td></tr><tr><td> </td><td> </td><td>COMSTO</td><td>25.7</td><td>8.5</td><td>63.4</td><td>5.6</td><td>163.5</td><td>21.4</td><td>123.2</td><td>33.3</td></tr><tr><td> </td><td> </td><td>DORGAN</td><td>13.2</td><td>48.4</td><td> </td><td> </td><td> </td><td> </td><td>51.4</td><td>217.4</td></tr><tr><td> </td><td> </td><td>HAENSZ</td><td>9.0</td><td>42.4</td><td>12.8</td><td>1.7</td><td>9.8</td><td>15.3</td><td>10.0</td><td>17.4</td></tr><tr><td> </td><td> </td><td>LOMBA2</td><td>20.2</td><td>57.9</td><td> </td><td> </td><td> </td><td> </td><td>10.7</td><td>47.2</td></tr><tr><td> </td><td> </td><td>OSANN</td><td>12.9</td><td>48.7</td><td>76.4</td><td>42.6</td><td>157.6</td><td>159.9</td><td>129.3</td><td>235.9</td></tr><tr><td> </td><td> </td><td>OSANN2</td><td>11.1</td><td>19.0</td><td>19.8</td><td>6.3</td><td>38.6</td><td>25.2</td><td>33.0</td><td>39.6</td></tr><tr><td> </td><td> </td><td>WYNDE3</td><td>16.6</td><td>17.3</td><td> </td><td> </td><td> </td><td> </td><td>31.5</td><td>23.0</td></tr><tr><td> </td><td> </td><td>WYNDE4</td><td>11.2</td><td>18.4</td><td> </td><td> </td><td> </td><td> </td><td>6.7</td><td>2.1</td></tr><tr><td> </td><td> </td><td>WYNDE6</td><td>13.0</td><td>62.4</td><td>65.6</td><td>126.3</td><td>156.5</td><td>265.1</td><td>178.5</td><td>250.4</td></tr><tr><td>SC America</td><td>Cuba</td><td>JOLY</td><td>17.8</td><td>21.7</td><td> </td><td> </td><td> </td><td> </td><td>54.4</td><td>24.4</td></tr><tr><td>UK</td><td> </td><td>ALDERS</td><td>8.2</td><td>8.6</td><td> </td><td> </td><td> </td><td> </td><td>29.5</td><td>24.4</td></tr><tr><td> </td><td> </td><td>DOLL</td><td>3.3</td><td>4.5</td><td> </td><td> </td><td> </td><td> </td><td>6.4</td><td>6.7</td></tr><tr><td rowspan="2">Scandinavia</td><td>Norway</td><td>KREYBE</td><td>21.7</td><td>9.6</td><td> </td><td> </td><td> </td><td> </td><td>16.1</td><td>5.9</td></tr><tr><td>Sweden</td><td>NOU</td><td>29.8</td><td>15.6</td><td> </td><td> </td><td> </td><td> </td><td>26.3</td><td>6.8</td></tr><tr><td> </td><td>Sweden</td><td>SVENSS</td><td>8.8</td><td>18.5</td><td>16.0</td><td>9.0</td><td>34.3</td><td>22.1</td><td>26.9</td><td>31.8</td></tr><tr><td rowspan="2">W Europe</td><td>Germany</td><td>BECHER</td><td>2.9</td><td>1.0</td><td> </td><td> </td><td> </td><td> </td><td>31.7</td><td>17.4</td></tr><tr><td>France</td><td>BENHAM</td><td>5.8</td><td>18.2</td><td> </td><td> </td><td> </td><td> </td><td>14.0</td><td>3.9</td></tr><tr><td> </td><td>Greece</td><td>KATSOU</td><td>24.3</td><td>28.2</td><td>40.7</td><td>1.8</td><td>45.2</td><td>9.1</td><td>44.4</td><td>11.3</td></tr><tr><td> </td><td>Austria</td><td>VUTUC</td><td>19.6</td><td>52.8</td><td>31.2</td><td>9.5</td><td>29.2</td><td>12.0</td><td>30.1</td><td>21.1</td></tr><tr><td>E Europe</td><td>Hungary</td><td>ABRAHA</td><td>17.2</td><td>17.2</td><td> </td><td> </td><td> </td><td> </td><td>45.1</td><td>20.7</td></tr><tr><td> </td><td>Poland</td><td>STASZE</td><td>8.6</td><td>13.9</td><td> </td><td> </td><td> </td><td> </td><td>9.4</td><td>1.0</td></tr><tr><td>Japan</td><td> </td><td>SOBUE</td><td>39.7</td><td>204.0</td><td>77.5</td><td>16.1</td><td>56.1</td><td>34.8</td><td>62.0</td><td>55.6</td></tr><tr><td> </td><td> </td><td>WAKAI</td><td>44.0</td><td>81.8</td><td>110.9</td><td>2.3</td><td>48.0</td><td>7.5</td><td>58.1</td><td>10.8</td></tr><tr><td>China</td><td>HK</td><td>CHAN</td><td>50.9</td><td>29.4</td><td> </td><td> </td><td> </td><td> </td><td>99.1</td><td>17.4</td></tr><tr><td> </td><td>China</td><td>GAO</td><td>64.3</td><td>305.7</td><td> </td><td> </td><td> </td><td> </td><td>69.8</td><td>46.1</td></tr><tr><td> </td><td>HK</td><td>KOO</td><td>60.0</td><td>35.0</td><td> </td><td> </td><td> </td><td> </td><td>96.4</td><td>22.3</td></tr><tr><td> </td><td>HK</td><td>LAMTH</td><td>100.4</td><td>73.4</td><td> </td><td> </td><td> </td><td> </td><td>187.6</td><td>31.3</td></tr><tr><td> </td><td>HK</td><td>LAMWK</td><td>94.0</td><td>49.2</td><td> </td><td> </td><td> </td><td> </td><td>198.0</td><td>20.5</td></tr><tr><td> </td><td>HK</td><td>LAMWK2</td><td>75.5</td><td>32.8</td><td> </td><td> </td><td> </td><td> </td><td>133.2</td><td>17.4</td></tr><tr><td> </td><td>China</td><td>WUWILL</td><td>45.7</td><td>184.2</td><td> </td><td> </td><td> </td><td> </td><td>62.8</td><td>124.3</td></tr><tr><td> </td><td>China</td><td>XU3</td><td>34.5</td><td>7.9</td><td> </td><td> </td><td> </td><td> </td><td>44.8</td><td>3.5</td></tr><tr><td> </td><td>China</td><td>ZHOU</td><td>54.0</td><td>77.0</td><td> </td><td> </td><td> </td><td> </td><td>77.2</td><td>6.8</td></tr><tr><td>Other</td><td>S Korea</td><td>CHOI</td><td>20.9</td><td>50.9</td><td> </td><td> </td><td> </td><td> </td><td>13.5</td><td>4.3</td></tr><tr><td> </td><td>Singapore</td><td>SEOW</td><td>66.1</td><td>30.8</td><td> </td><td> </td><td> </td><td> </td><td>156.2</td><td>7.8</td></tr></table>
85c26c4a118c9e40ab9387edfd4f4428d69816747204cf433e035f9541fced01.png
simple
<table><tr><td>Measurand</td><td>Description</td><td>Nominal Value</td><td>Tolerance</td></tr><tr><td>L</td><td>Length</td><td>11.80 mm</td><td>&#177;0.03 mm</td></tr><tr><td>a, c</td><td>Length</td><td>3.00 mm</td><td>&#177;0.03 mm</td></tr><tr><td>b</td><td>Length</td><td>1.50 mm</td><td>&#177;0.02 mm</td></tr><tr><td>d</td><td>Length</td><td>1.35 mm</td><td>&#177;0.02 mm</td></tr><tr><td>A, B, C, D, E, F</td><td>Thickness</td><td>1.00 mm</td><td>&#177;0.02 mm</td></tr></table>
e2c3d1c8013edef8bdd56aab9c4c37583c024a2a270e4a4312f188cd61884a71.png
simple
<table><tr><td>Neutropenia</td><td>N</td></tr><tr><td>G2-G3</td><td>3 (10%)</td></tr><tr><td>G4</td><td>1 (4%)</td></tr><tr><td>Anemia</td><td>N</td></tr><tr><td>G2-G3</td><td>3 (10%)</td></tr><tr><td>G4</td><td>_</td></tr><tr><td>Thrombocytopenia</td><td>N</td></tr><tr><td>G2-G3</td><td>1(4%)</td></tr><tr><td>G4</td><td>_</td></tr></table>
7cd50c28cad6ca0927a8ba79e34f3d6e2eeec91aa0465d5fd6a1f8da3c8392b9.png
simple
<table><tr><td></td><td>N</td><td>Ne</td><td>He</td><td>He + siRNA</td></tr><tr><td>CLK1</td><td>1</td><td>5.30</td><td>19.70</td><td>6.57</td></tr><tr><td>CGADD45A</td><td>1</td><td>1.33</td><td>0.71</td><td>1.01</td></tr><tr><td>IGFPB4</td><td>1</td><td>2.06</td><td>1.21</td><td>2.14</td></tr><tr><td>MCL1</td><td>1</td><td>1.69</td><td>1.16</td><td>2.09</td></tr><tr><td>BIRC2</td><td>1</td><td>0.73</td><td><underline>0.41</underline></td><td><underline>0.44</underline></td></tr><tr><td>BIRC4</td><td>1</td><td>0.76</td><td><underline>0.35</underline></td><td><underline>0.25</underline></td></tr><tr><td>BIRC3</td><td>1</td><td>0.93</td><td>2.52</td><td><underline>0.35*</underline></td></tr><tr><td>ING</td><td>1</td><td>1.08</td><td><underline>0.41</underline></td><td><underline>0.43</underline></td></tr><tr><td>JUN</td><td>1</td><td>1.50</td><td>1.23</td><td>2.66</td></tr><tr><td>MAP2K1</td><td>1</td><td>0.82</td><td><underline>0.58</underline></td><td>0.78</td></tr><tr><td>TANK</td><td>1</td><td>5.42</td><td><underline>0.38</underline></td><td><underline>0.37</underline></td></tr><tr><td>BAX</td><td>1</td><td>1.53</td><td><underline>0.59</underline></td><td>0.87</td></tr><tr><td>IGFBP2</td><td>1</td><td>1.13</td><td>0.77</td><td>0.92</td></tr><tr><td>MDM2</td><td>1</td><td>3.90</td><td>1.28</td><td>2.28</td></tr><tr><td>BAK1</td><td>1</td><td>2.35</td><td>0.69</td><td>1.69*</td></tr><tr><td>CDKN1A</td><td>1</td><td>2.61</td><td>0.65</td><td>1.41</td></tr><tr><td>GPX1</td><td>1</td><td>2.27</td><td>0.59</td><td>1.09</td></tr><tr><td>CDC2</td><td>1</td><td>0.89</td><td>0.29</td><td>0.35</td></tr><tr><td>PCNA</td><td>1</td><td>2.11</td><td><underline>0.49</underline></td><td>1.06</td></tr><tr><td>AKT2</td><td>1</td><td>4.46</td><td>2.31</td><td>1.90</td></tr><tr><td>E2F5</td><td>1</td><td>1.23</td><td><underline>0.24</underline></td><td><underline>0.14</underline></td></tr></table>
ce6a385f93702334affc7ddfc30e06e0321c9161c18a967e78494ad39c774f99.png
complex
<table><tr><td rowspan="2"></td><td>Group A</td><td>Group B</td><td rowspan="2"></td></tr><tr><td>(URL + RIRS)</td><td>(URL alone)</td></tr><tr><td>Variable</td><td>72 patients</td><td>72 patients</td><td>P</td></tr><tr><td>Follow-up, mean, (SD), range (months)</td><td>18.9 (10.2),14&#8211;32</td><td>18.5 (9.4),12&#8211;34</td><td>0.675</td></tr><tr><td>Auxiliary treatment rate, no. (%)</td><td>4 (5.6)</td><td>50 (69.4)</td><td>&lt;0.001</td></tr><tr><td>Cause of auxiliary treatment in follow-up, no. (%)</td><td></td><td></td><td></td></tr><tr><td> Renal colic</td><td>2 (2.8)</td><td>10 (13.9)</td><td></td></tr><tr><td> Repetatus urinary tract infection</td><td>0</td><td>6 (8.3)</td><td></td></tr><tr><td> Stone induced hematuria</td><td>2 (2.8)</td><td>10 (13.9)</td><td></td></tr><tr><td>Increase in creatinine levels</td><td>0</td><td>4 (5.6)</td><td></td></tr><tr><td>Patient&#8217;s desire (increased stone duration)</td><td>0</td><td>20 (27.8)</td><td></td></tr><tr><td>Medical expulsive treatment, no. (%)</td><td>2 (2.8)</td><td>4 (5.6)</td><td>&lt;0.001</td></tr><tr><td>Patients required auxiliary procedures, no (%).</td><td>2 (2.8)</td><td>46 (63.9)</td><td>&lt;0.001</td></tr><tr><td>Auxiliary procedures, no</td><td>2</td><td>62</td><td>-</td></tr><tr><td> URL</td><td>0</td><td>10</td><td></td></tr><tr><td> FURL</td><td>0</td><td>12</td><td></td></tr><tr><td> ESWL</td><td>0</td><td>26</td><td></td></tr><tr><td> PCNL</td><td>2</td><td>4</td><td></td></tr><tr><td>Procedure per patient, mean, (SD), range</td><td>1.03 (0.17),1&#8211;2</td><td>1.86 (0.76),1&#8211;3</td><td>&lt;0.001</td></tr><tr><td rowspan="2">Medical cost per patient, mean, (SD), range (RMB)</td><td>16431.2 (3425.3)</td><td>13125.1 (2165.4)</td><td rowspan="2">&lt;0.001</td></tr><tr><td>14985.3&#8211;21325.4</td><td>9105.1&#8211;15143.2</td></tr></table>
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complex
<table><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td colspan="2">NOS</td></tr><tr><td>Study design</td><td>First author, year</td><td>Participants</td><td>Age range (years)</td><td>Definition of tooth loss</td><td>Focal point</td><td>Dose-response</td><td>Coding</td><td>Score</td></tr><tr><td>Cross-sectional study</td><td>Randolph, 2001</td><td>3,050 Mexican American</td><td>65-99</td><td>15+</td><td>F</td><td>NA</td><td>011 11 1</td><td>5*</td></tr><tr><td></td><td>Klein, 2004</td><td>2,764 American</td><td>53-96</td><td>1+</td><td>F</td><td>NA</td><td>011 11 1</td><td>5*</td></tr><tr><td></td><td>Tanaka, 2005</td><td>1,002 Japanese pregnant women</td><td>29.8 on average</td><td>1+</td><td>S</td><td>NA</td><td>010 11 0</td><td>3</td></tr><tr><td></td><td>Hanioka, 2007</td><td>2,200 Japanese</td><td>60-94</td><td>Total tooth loss</td><td>S</td><td>NA</td><td>101 10 1</td><td>4</td></tr><tr><td></td><td>Musacchio, 2007</td><td>1,226 Italian males</td><td>65+</td><td>Total tooth loss</td><td>S</td><td>NA</td><td>101 11 1</td><td>5*</td></tr><tr><td></td><td>Ojima, 2007</td><td>1,314 Japanese</td><td>20-39</td><td>1+</td><td>S</td><td>3/4 levels</td><td>111 01 1</td><td>5*</td></tr><tr><td></td><td>Hanioka, 2007</td><td>3,999 Japanese</td><td>40-94</td><td>9+</td><td>S</td><td>3/4 levels</td><td>111 11 1</td><td>6*</td></tr><tr><td></td><td>Mundt, 2007</td><td>2,501 German</td><td>25-59</td><td>15th percentile</td><td>F</td><td>3 levels</td><td>111 11 1</td><td>6*</td></tr><tr><td></td><td>Yanagisawa, 2009</td><td>547 Japanese males</td><td>55-75</td><td>9+</td><td>S</td><td>3 levels</td><td>110 11 0</td><td>4</td></tr><tr><td></td><td>Yanagisawa, 2010</td><td>1,088 Japanese males</td><td>40-75</td><td>9+</td><td>S</td><td>3 levels</td><td>110 11 0</td><td>4</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td colspan="2">NOS</td></tr><tr><td>Study design</td><td>First author, year</td><td>Participants</td><td>Age range (years)</td><td>Duration of observation</td><td>Focal point</td><td>Dose-response</td><td>Coding</td><td>Score</td></tr><tr><td>Cohort study</td><td>Slade, 1997</td><td>693 Australian</td><td>60+</td><td>2 years</td><td>F</td><td>NA</td><td>10 01 110</td><td>4</td></tr><tr><td></td><td>Krall, 2006</td><td>789 American males</td><td>21-84</td><td>36 years</td><td>S</td><td>NA</td><td>00 11 111</td><td>5*</td></tr><tr><td></td><td>Okamoto, 2006</td><td>740 Japanese males</td><td>30-59</td><td>4 years</td><td>S</td><td>3 levels</td><td>00 10 110</td><td>3</td></tr><tr><td></td><td>Dietrich, 2007</td><td>43,112 American male health professionals</td><td>40-75</td><td>16 years</td><td>S</td><td>5 levels</td><td>01 11 111</td><td>6*</td></tr><tr><td></td><td>Cunha-Cruz, 2008</td><td>12,264 American HMO members</td><td>45-61</td><td>3 years</td><td>A</td><td>NA</td><td>00 10 110</td><td>3</td></tr></table>
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<table><tr><td> </td><td colspan="2">Males (n=195)</td><td colspan="2">Females (n=228)</td><td><i>P</i></td></tr><tr><td><i>Anthropometric variables</i></td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>Height (cm)</td><td>175.0</td><td>6.8</td><td>162.5</td><td>6.7</td><td>0.000</td></tr><tr><td>Weight (kg)</td><td>66.2</td><td>12.2</td><td>59.8</td><td>14.6</td><td>0.000</td></tr><tr><td>Body mass index (kg/m<sup>2</sup>)</td><td>21.6</td><td>3.6</td><td>22.7</td><td>3.3</td><td>0.016</td></tr><tr><td> &#8805; 25</td><td>13.3</td><td> </td><td>26.7</td><td> </td><td>0.000</td></tr><tr><td> &#8805; 30</td><td>4.6</td><td> </td><td>10.5</td><td> </td><td>0.000</td></tr><tr><td>Waist (cm)</td><td>75.9</td><td>8.6</td><td>75.7</td><td>11.2</td><td>ns</td></tr><tr><td> &#8805; 94 (M); &#8805;80 (F)</td><td>5.6</td><td> </td><td>28.5</td><td> </td><td>0.000</td></tr><tr><td> &#8805;102 (M); &#8805;88 (F)</td><td>2.1</td><td> </td><td>14.9</td><td> </td><td>0.000</td></tr><tr><td>Waist/height ratio</td><td>43.3</td><td>3.5</td><td>46.6</td><td>4.6</td><td>0.000</td></tr><tr><td> &#8805;0.50</td><td>9.7</td><td> </td><td>26.7</td><td> </td><td>0.000</td></tr><tr><td>Waist/hip ratio</td><td>0.83</td><td>0.07</td><td>0.82</td><td>0.09</td><td>0.017</td></tr><tr><td>Fat percent</td><td>16.8</td><td>6.7</td><td>26.8</td><td>7.9</td><td>0.000</td></tr><tr><td><i>Cardiovascular risk factors</i></td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>Daily cigarette smoking</td><td>20.0</td><td> </td><td>3.1</td><td> </td><td>0.000</td></tr><tr><td>Alcohol on &#8805;6 days/month</td><td>19.5</td><td> </td><td>5.7</td><td> </td><td>0.000</td></tr><tr><td>Physical activity &gt;3000 MET-min/wk</td><td>64.4</td><td> </td><td>18.4</td><td> </td><td>0.000</td></tr><tr><td>Systolic blood pressure (mmHg)</td><td>121.2</td><td>11.2</td><td>110.5</td><td>10.0</td><td>0.000</td></tr><tr><td>Diastolic blood pressure (mmHg)</td><td>67.0</td><td>8.1</td><td>69.1</td><td>8.0</td><td>0.008</td></tr><tr><td>Total cholesterol (mmol/l)</td><td>4.06</td><td>0.81</td><td>4.23</td><td>0.86</td><td>0.031</td></tr><tr><td>LDL-cholesterol (mmol/l)</td><td>2.28</td><td>0.74</td><td>2.56</td><td>0.81</td><td>0.000</td></tr><tr><td>HDL-cholesterol (mmol/l)</td><td>1.46</td><td>0.43</td><td>1.36</td><td>0.39</td><td>0.011</td></tr><tr><td>Triglycerides (mmol/l)</td><td>0.69</td><td>0.28</td><td>0.69</td><td>0.28</td><td>ns</td></tr><tr><td>Glucose (mmol/l)</td><td>5.24</td><td>0.58</td><td>4.96</td><td>0.58</td><td>0.000</td></tr><tr><td>Uric acid (mmol/l)</td><td>0.33</td><td>0.08</td><td>0.24</td><td>0.70</td><td>0.000</td></tr></table>
5c7575a1d69d92483e52a908e51d5a82acafc6566d78e4c128446ee65f442932.png
simple
<table><tr><td>KEGG pathways<sup>a</sup></td><td>Percentage of significant CM genes<sup>b</sup></td></tr><tr><td>Ribosome</td><td>13.3</td></tr><tr><td>Cell adhesion molecules (CAMs)</td><td>10.0</td></tr><tr><td>Antigen processing and presentation</td><td>8.3</td></tr><tr><td>Oxidative phosphorylation</td><td>6.7</td></tr><tr><td>Hematopoietic cell lineage</td><td>6.7</td></tr><tr><td>Leukocyte transendothelial migration</td><td>6.7</td></tr><tr><td>ECM-receptor interaction</td><td>6.7</td></tr><tr><td>Cytokine-cytokine receptor interaction</td><td>5.0</td></tr><tr><td>Glycolysis/Gluconeogenesis</td><td>5.0</td></tr><tr><td>Fructose and mannose metabolism</td><td>5.0</td></tr><tr><td>Regulation of actin cytoskeleton</td><td>5.0</td></tr><tr><td>T cell receptor signaling pathway</td><td>5.0</td></tr><tr><td>Jak-STAT signalling pathway</td><td>5.0</td></tr><tr><td>Axon guidance</td><td>5.0</td></tr><tr><td>Valine, leucine and isoleucine degradation</td><td>5.0</td></tr><tr><td>Focal adhesion</td><td>5.0</td></tr><tr><td>Tight junction</td><td>5.0</td></tr><tr><td>MAPK signaling pathway</td><td>3.3</td></tr><tr><td>B cell receptor signaling pathway</td><td>3.3</td></tr><tr><td>Tryptophan metabolism</td><td>3.3</td></tr><tr><td>Propanoate metabolism</td><td>3.3</td></tr><tr><td>Butanoate metabolism</td><td>3.3</td></tr><tr><td>Bile acid biosynthesis</td><td>3.3</td></tr><tr><td>Fatty acid metabolism</td><td>3.3</td></tr><tr><td>Adipocytokine signaling pathway</td><td>3.3</td></tr><tr><td>Neuroactive ligand-receptor interaction</td><td>3.3</td></tr><tr><td>Neurodegenerative Disorders</td><td>3.3</td></tr></table>
105aefe1cbccbe752e40c1b73c9b6f1a8edf728e8654d383d6f064073c9c0fcf.png
complex
<table><tr><td rowspan="2"></td><td>Samples</td><td></td><td></td><td>Polyomavirus No. (%)</td><td></td><td>Ref. virus No. (%)</td></tr><tr><td></td><td>Total No.</td><td><i>MWPyV</i></td><td><i>JCPyV</i></td><td><i>BKPyV</i></td><td><i>EBV</i></td></tr><tr><td>Healthy children</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>No. 200</td><td>Tonsil</td><td>100</td><td>6 (6 %)</td><td>0</td><td>0</td><td>38 (38 %)</td></tr><tr><td></td><td>Adenoid</td><td>100</td><td>1 (1 %)</td><td>0</td><td>0</td><td>37 (37 %)</td></tr><tr><td></td><td>Blood</td><td>100</td><td>0</td><td>0</td><td>0</td><td>12 (12 %)</td></tr><tr><td></td><td>Urine</td><td>100</td><td>0</td><td>0</td><td>0</td><td>&#8211;</td></tr><tr><td></td><td>Stool<sup>a</sup></td><td>100</td><td>0</td><td>0</td><td>0</td><td>&#8211;</td></tr><tr><td></td><td>Total No.</td><td>500</td><td>7 (1.4 %)</td><td>0</td><td>0</td><td>&#8211;</td></tr><tr><td>Autoimmune children</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>No. 40</td><td>Blood</td><td>40</td><td>0</td><td>6 (15 %)</td><td>0</td><td>2 (5 %)</td></tr><tr><td></td><td>Urine</td><td>40</td><td>0</td><td>40 (100 %)</td><td>5 (12.5 %)</td><td>&#8211;</td></tr><tr><td></td><td>Total No.</td><td>80</td><td>0</td><td>46 (57.5 %)</td><td>5 (6.25 %)</td><td>&#8211;</td></tr></table>
1ca0d91b01abb16a61276ce36fdcd73e48e259435da76168a3c6e3077c056650.png
complex
<table><tr><td><i>Socioeconomic position</i></td><td colspan="2"><i>Total group</i></td><td colspan="2"><i>Boys</i></td><td colspan="2"><i>Girls</i></td></tr><tr><td> </td><td><i>Crude OR (95% CI)</i></td><td><i>Adjusted</i>b<i>OR (95% CI)</i></td><td><i>Crude OR (95% CI)</i></td><td><i>Adjusted</i>c<i>OR (95% CI)</i></td><td><i>Crude OR (95% CI)</i></td><td><i>Adjusted</i>c<i>OR (95% CI)</i></td></tr><tr><td colspan="7"><i>Maternal education</i>d</td></tr><tr><td> High education</td><td>1.0 (Reference)</td><td> </td><td>1.0 (Reference)</td><td> </td><td>1.0 (Reference)</td><td> </td></tr><tr><td> Low education</td><td>1.08 (1.00&#8211;1.18)</td><td>0.94 (0.86&#8211;1.03)</td><td>1.04 (0.93&#8211;1.17)</td><td>0.93 (0.82&#8211;1.05)</td><td>1.13 (1.00&#8211;1.27)</td><td>0.96 (0.85&#8211;1.09)</td></tr><tr><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td colspan="7"><i>Paternal education</i>d</td></tr><tr><td> High education</td><td>1.0 (Reference)</td><td> </td><td>1.0 (Reference)</td><td> </td><td>1.0 (Reference)</td><td> </td></tr><tr><td> Low education</td><td>1.22*** (1.11&#8211;1.33)</td><td>1.05 (0.96&#8211;1.16)</td><td>1.21** (1.07&#8211;1.37)</td><td>1.08 (0.94&#8211;1.23)</td><td>1.23** (1.07&#8211;1.40)</td><td>1.03 (0.90&#8211;1.19)</td></tr><tr><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td colspan="7"><i>Maternal occupation</i>e</td></tr><tr><td> Employed</td><td>1.0 (Reference)</td><td> </td><td>1.0 (Reference)</td><td> </td><td>1.0 (Reference)</td><td> </td></tr><tr><td> Unemployed&#8211;able to work</td><td>0.78** (0.65&#8211;0.93)</td><td>0.67*** (0.56&#8211;0.81)</td><td>0.80 (0.63&#8211;1.03)</td><td>0.71** (0.55&#8211;0.92)</td><td>0.76* (0.58&#8211;0.99)</td><td>0.63*** (0.48&#8211;0.82)</td></tr><tr><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td colspan="7"><i>Paternal occupation</i>e</td></tr><tr><td> Employed</td><td>1.0 (Reference)</td><td> </td><td>1.0 (Reference)</td><td> </td><td>1.0 (Reference)</td><td> </td></tr><tr><td> Unemployed&#8211;able to work</td><td>0.78** (0.65&#8211;0.94)</td><td>0.72*** (0.60&#8211;0.88)</td><td>0.91 (0.70&#8211;1.17)</td><td>0.87 (0.67&#8211;1.12)</td><td>0.66** (0.49&#8211;0.87)</td><td>0.59*** (0.44&#8211;0.78)</td></tr></table>
bd50a9268ad29e51cf8ddd8bbfce2a91148f4213943333a058a56aacf569985d.png
simple
<table><tr><td>Substrate</td><td>Relative Activity (%)</td></tr><tr><td><i>o</i>-nitrophenyl-&#946;-d-galactopyranoside</td><td>100</td></tr><tr><td><i>p</i>-nitrophenyl-&#946;-d-galactopyranoside</td><td>422</td></tr><tr><td><i>p</i>-nitrophenyl-&#946;-d-glucopyranoside</td><td>&lt;1</td></tr><tr><td><i>p</i>-nitrophenyl-&#946;-d-xylopyranoside</td><td>&lt;1</td></tr><tr><td><i>p</i>-nitrophenyl-&#946;-d-lactopyranoside</td><td>&lt;1</td></tr><tr><td><i>p</i>-nitrophenyl-&#946;-d-glucuronide</td><td>&lt;1</td></tr><tr><td><i>p</i>-nitrophenyl-a-d-galactopyranoside</td><td>&lt;1</td></tr><tr><td><i>p</i>-nitrophenyl-&#946;-l-arabinopyranoside</td><td>&lt;1</td></tr><tr><td><i>p</i>-nitrophenyl-&#946;-d-cellobioside</td><td>&lt;1</td></tr></table>
a8a4fd4161764c578b3679ca57af73ac06cbc0265764e7b43fedb5c375089ad7.png
simple
<table><tr><td>Database</td><td>SI</td><td>VO</td><td>VD</td><td>AD</td><td>RMSD</td><td>MD</td></tr><tr><td>IO on URNC</td><td>80.56</td><td>67.80</td><td>22.84</td><td>0.003</td><td>0.092</td><td>92.54</td></tr></table>
39e47dece9f1bbad436a052c479b41e269dcdd5108d231c76c82b2df98ce286b.png
complex
<table><tr><td>Questions (<i>n </i>= 10)</td><td colspan="3">Answers</td></tr><tr><td></td><td>D</td><td>N</td><td>A</td></tr><tr><td>The explanation of the GLIA dimensions is clear</td><td>2</td><td>2</td><td>6</td></tr><tr><td>The explanation of the use of the eGLIA tool is clear</td><td>0</td><td>1</td><td>9</td></tr><tr><td>The eGLIA tool is easy to use</td><td>2</td><td>1</td><td>7</td></tr><tr><td>The tool questions are easy to understand and apply</td><td>2</td><td>6</td><td>2</td></tr><tr><td>The tool questions were relevant to assessing implementability</td><td>0</td><td>4</td><td>6</td></tr><tr><td>The eGLIA tool helped identify obstacles to implementation</td><td>1</td><td>1</td><td>8</td></tr><tr><td>The eGLIA helped to judge recommendations systematically</td><td>0</td><td>1</td><td>9</td></tr><tr><td>Will use the eGLIA more often</td><td>1</td><td>3</td><td>6</td></tr></table>
7dcb6e88fd4df0ae03bf838ef735ebf523abe6f2355ee12c8c8a93d955c1db6b.png
complex
<table><tr><td></td><td colspan="2">haematocrit 25%</td><td colspan="2">haematocrit 20%</td><td><i>P </i>value</td></tr><tr><td></td><td>Median</td><td>IQR</td><td>Median</td><td>IQR</td><td></td></tr><tr><td>CI during CPB(l/m<sup>2</sup>/min)</td><td>3.2</td><td>3.0-3.6</td><td>3.2</td><td>3.0-3.5</td><td>0.40</td></tr><tr><td>Temperature during CPB(&#176;C)</td><td>35.5</td><td>35.0-35.9</td><td>35.7</td><td>35.4-36.0</td><td>0.21</td></tr><tr><td>Cumulative norepinephrine-dosage during CPB (mg)</td><td>0.06</td><td>0.04-0.09</td><td>0.05</td><td>0.02-0.09</td><td>0.41</td></tr><tr><td>Urine volume during CPB(mL)</td><td>148</td><td>80-250</td><td>150</td><td>86-177</td><td>0.94</td></tr><tr><td>duration of anaesthesia(min)</td><td>300</td><td>290-320</td><td>313</td><td>295-338</td><td>0.16</td></tr><tr><td>duration of surgery(min)</td><td>200</td><td>160-220</td><td>203</td><td>175-243</td><td>0.21</td></tr><tr><td>CPB time(min)</td><td>74</td><td>52-83</td><td>71</td><td>63-81</td><td>0.72</td></tr><tr><td>aortic cross clamp time(min)</td><td>45</td><td>32-58</td><td>44</td><td>38-49</td><td>0.81</td></tr><tr><td>Length of ICU treatment(hours)</td><td>22</td><td>20-24</td><td>23</td><td>21-27</td><td>0.29</td></tr><tr><td>Length of mechanical ventilation(hours)</td><td>10</td><td>8-13</td><td>11</td><td>10-14</td><td>0.10</td></tr><tr><td>APACHE II score</td><td>14</td><td>10-19</td><td>16</td><td>14-17</td><td>0.13</td></tr></table>
219d151153e6a873c442028c69fb3e7a58600f7c95ee90c70d427646854a022e.png
complex
<table><tr><td>Characteristic</td><td>Category</td><td>n</td><td>Proportion (%)</td></tr><tr><td rowspan="2">Sex</td><td>Male</td><td>1021</td><td>45.6</td></tr><tr><td>Female</td><td>1220</td><td>54.4</td></tr><tr><td rowspan="6">Age (years)</td><td>15&#8211;24</td><td>263</td><td>11.7</td></tr><tr><td>25&#8211;34</td><td>564</td><td>25.2</td></tr><tr><td>35&#8211;44</td><td>399</td><td>17.8</td></tr><tr><td>45&#8211;54</td><td>436</td><td>19.5</td></tr><tr><td>55&#8211;64</td><td>276</td><td>12.3</td></tr><tr><td>&#8805;65</td><td>303</td><td>13.5</td></tr><tr><td rowspan="7">Education level</td><td>No formal education</td><td>100</td><td>4.5</td></tr><tr><td>Elementary school</td><td>200</td><td>8.9</td></tr><tr><td>Junior middle school</td><td>543</td><td>24.2</td></tr><tr><td>Senior middle school</td><td>667</td><td>29.8</td></tr><tr><td>Bachelor level</td><td>654</td><td>29.2</td></tr><tr><td>Master level or above</td><td>71</td><td>3.2</td></tr><tr><td>Unanswered</td><td>6</td><td>0.2</td></tr><tr><td rowspan="5">Marital status</td><td>Unmarried</td><td>363</td><td>16.2</td></tr><tr><td>Married</td><td>1764</td><td>78.7</td></tr><tr><td>Divorced</td><td>13</td><td>0.6</td></tr><tr><td>Widowed</td><td>89</td><td>4.0</td></tr><tr><td>Unanswered</td><td>12</td><td>0.5</td></tr><tr><td rowspan="4">Labor force status</td><td>Employed *</td><td>1505</td><td>67.2</td></tr><tr><td>Unemployed</td><td>230</td><td>10.3</td></tr><tr><td>Retired</td><td>322</td><td>14.4</td></tr><tr><td>Student</td><td>184</td><td>8.2</td></tr><tr><td rowspan="6">Monthly income (RMB)</td><td>&lt;2000</td><td>562</td><td>25.1</td></tr><tr><td>2000&#8211;3000</td><td>758</td><td>33.8</td></tr><tr><td>3000&#8211;5000</td><td>616</td><td>27.5</td></tr><tr><td>5000&#8211;10,000</td><td>225</td><td>10.0</td></tr><tr><td>&gt;10,000</td><td>40</td><td>1.8</td></tr><tr><td>Unanswered</td><td>40</td><td>1.8</td></tr><tr><td rowspan="2">Hukou</td><td>Urban</td><td>1379</td><td>61.5</td></tr><tr><td>Rural</td><td>862</td><td>38.5</td></tr></table>
2a84e86f73e108210d410c7e4bc2c8c129c52507ed97ad737e6863db03c9c45d.png
complex
<table><tr><td></td><td colspan="2">All<i>N</i> = 1135</td><td></td><td colspan="2">Male<i>N</i> = 627</td><td></td><td colspan="2">Female<i>N</i> = 508</td><td></td><td rowspan="2"><i>p</i><sup>a</sup></td></tr><tr><td></td><td>Mean</td><td>(SD)</td><td></td><td>Mean</td><td>(SD)</td><td></td><td>Mean</td><td>(SD)</td><td></td></tr><tr><td>Energy intake (kcal)</td><td>2274</td><td>(246)</td><td></td><td>2337</td><td>(238)</td><td></td><td>2198</td><td>(233)</td><td></td><td>&lt;0.001</td></tr><tr><td>Energy intake (kJ)</td><td>9782</td><td>(1057)</td><td></td><td>10049</td><td>(1023)</td><td></td><td>9453</td><td>(1004)</td><td></td><td>&lt;0.001</td></tr><tr><td>Macronutrients</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> Proteins (g)</td><td>57.9</td><td>(13.6)</td><td></td><td>62.3</td><td>(14.5)</td><td></td><td>52.4</td><td>(9.9)</td><td></td><td>&lt;0.001</td></tr><tr><td> Carbohydrates (g)</td><td>309.0</td><td>(105.9)</td><td></td><td>327.9</td><td>(102.4)</td><td></td><td>285.7</td><td>(105.5)</td><td></td><td>&lt;0.001</td></tr><tr><td> Total sugar (g)</td><td>133.8</td><td>(16.0)</td><td></td><td>146.4</td><td>(9.6)</td><td></td><td>118.2</td><td>(4.4)</td><td></td><td>&lt;0.001</td></tr><tr><td> Fat (g)</td><td>94.7</td><td>(9.4)</td><td></td><td>96.7</td><td>(9.3)</td><td></td><td>92.2</td><td>(8.9)</td><td></td><td>&lt;0.001</td></tr><tr><td> SFA (g)</td><td>31.8</td><td>(3.7)</td><td></td><td>33.7</td><td>(3.2)</td><td></td><td>29.3</td><td>(2.7)</td><td></td><td>&lt;0.001</td></tr><tr><td> MUFA (g)</td><td>26.9</td><td>(3.2)</td><td></td><td>27.8</td><td>(3.1)</td><td></td><td>25.8</td><td>(3.1)</td><td></td><td>&lt;0.001</td></tr><tr><td> PUFA (g)</td><td>10.4</td><td>(1.5)</td><td></td><td>11.0</td><td>(1.4)</td><td></td><td>9.6</td><td>(1.1)</td><td></td><td>&lt;0.001</td></tr><tr><td>Micronutrients</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> Cholesterol (mg)</td><td>236.1</td><td>(26.1)</td><td></td><td>237.4</td><td>(26.3)</td><td></td><td>234.4</td><td>(25.8)</td><td></td><td>0.060</td></tr><tr><td> Fiber (g)</td><td>33.4</td><td>(3.7)</td><td></td><td>35.4</td><td>(3.2)</td><td></td><td>31.0</td><td>(2.6)</td><td></td><td>&lt;0.001</td></tr><tr><td> Vitamin C (mg)</td><td>136.5</td><td>(14.8)</td><td></td><td>135.4</td><td>(14.7)</td><td></td><td>137.8</td><td>(14.9)</td><td></td><td>0.007</td></tr><tr><td> Vitamin A (&#956;g)</td><td>581.2</td><td>(71.3)</td><td></td><td>577.4</td><td>(70.5)</td><td></td><td>586.0</td><td>(72.1)</td><td></td><td>0.044</td></tr><tr><td> Vitamin B12 (&#956;g)</td><td>2.4</td><td>(1.0)</td><td></td><td>2.4</td><td>(1.0)</td><td></td><td>2.3</td><td>(1.01)</td><td></td><td>0.178</td></tr><tr><td> Folate (&#956;g)</td><td>271.0</td><td>(28.9)</td><td></td><td>270.9</td><td>(29.0)</td><td></td><td>271.2</td><td>(28.8)</td><td></td><td>0.886</td></tr><tr><td> Iron (mg)</td><td>7.2</td><td>(0.8)</td><td></td><td>7.2</td><td>(0.8)</td><td></td><td>7.2</td><td>(0.8)</td><td></td><td>0.144</td></tr><tr><td> Zinc (mg)</td><td>6.5</td><td>(0.5)</td><td></td><td>6.5</td><td>(0.5)</td><td></td><td>6.4</td><td>(0.5)</td><td></td><td>0.176</td></tr><tr><td> Calcium (mg)</td><td>922.6</td><td>(72.9)</td><td></td><td>920.5</td><td>(73.5)</td><td></td><td>925.2</td><td>(72.2)</td><td></td><td>0.280</td></tr><tr><td>Food groups</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> Pasta/rice (g)</td><td>58.5</td><td>(26.5)</td><td></td><td>57.9</td><td>(26.5)</td><td></td><td>59.1</td><td>(26.5)</td><td></td><td>0.552</td></tr><tr><td> Meat (g)</td><td>37.8</td><td>(27.4)</td><td></td><td>37.0</td><td>(27.1)</td><td></td><td>38.8</td><td>(27.7)</td><td></td><td>0.412</td></tr><tr><td> Fish (g)</td><td>13.5</td><td>(17.8)</td><td></td><td>14.3</td><td>(18.6)</td><td></td><td>12.4</td><td>(16.8)</td><td></td><td>0.060</td></tr><tr><td> Cheese (g)</td><td>19.2</td><td>(19.3)</td><td></td><td>19.1</td><td>(19.2)</td><td></td><td>19.2</td><td>(19.3)</td><td></td><td>0.851</td></tr><tr><td> Eggs (g)</td><td>9.6</td><td>(13.4)</td><td></td><td>9.6</td><td>(13.3)</td><td></td><td>9.6</td><td>(13.5)</td><td></td><td>0.857</td></tr><tr><td> Vegetables (g)</td><td>42.5</td><td>(62.9)</td><td></td><td>40.4</td><td>(62.2)</td><td></td><td>45.1</td><td>(63.7)</td><td></td><td>0.214</td></tr><tr><td> Fruit (g)</td><td>56.1</td><td>(65.7)</td><td></td><td>55.2</td><td>(66.6)</td><td></td><td>57.3</td><td>(64.7)</td><td></td><td>0.592</td></tr><tr><td> Sweets (g)</td><td>27.1</td><td>(38.7)</td><td></td><td>26.1</td><td>(35.5)</td><td></td><td>28.5</td><td>(42.2)</td><td></td><td>0.233</td></tr><tr><td> Fast foods (g)</td><td>44.8</td><td>(56.1)</td><td></td><td>47.5</td><td>(57.1)</td><td></td><td>41.4</td><td>(54.8)</td><td></td><td>0.072</td></tr><tr><td> Snacks (g)</td><td>18.9</td><td>(24.3)</td><td></td><td>19.2</td><td>(24.2)</td><td></td><td>18.5</td><td>(24.5)</td><td></td><td>0.623</td></tr><tr><td> Sugary Drinks (mL)</td><td>58.3</td><td>(85.0)</td><td></td><td>60.1</td><td>(85.0)</td><td></td><td>56.1</td><td>(85.1)</td><td></td><td>0.450</td></tr></table>
a23cfca70b44fe07102aad9ae9e03b3f40d00519b74205985ed4d136254af57e.png
simple
<table><tr><td></td><td>Both sexes (95% CI)</td><td>Male (95% CI)</td><td>Female (95% CI)</td></tr><tr><td>Life expectancy, y</td><td></td><td></td><td></td></tr><tr><td>1990</td><td>75.4</td><td>71.8</td><td>78.8</td></tr><tr><td>1995</td><td>75.8</td><td>72.5</td><td>78.9</td></tr><tr><td>The Average HALex</td><td></td><td></td><td></td></tr><tr><td> All ages</td><td></td><td></td><td></td></tr><tr><td>1990</td><td>0.87 (0.87, 0.88)</td><td>0.88 (0.88, 0.88)</td><td>0.87 (0.86, 0.87)</td></tr><tr><td>1995</td><td>0.87 (0.86, 0.87)</td><td>0.87 (0.87, 0.88)</td><td>0.86 (0.86, 0.86)</td></tr><tr><td> 0&#8211;14 years</td><td></td><td></td><td></td></tr><tr><td>1990</td><td>0.93 (0.93, 0.93)</td><td>0.93 (0.93, 0.93)</td><td>0.94 (0.93, 0.94)</td></tr><tr><td>1995</td><td>0.93 (0.93, 0.93)</td><td>0.93 (0.92, 0.93)</td><td>0.94 (0.93, 0.94)</td></tr><tr><td> 15&#8211;24 years</td><td></td><td></td><td></td></tr><tr><td>1990</td><td>0.92 (0.92, 0.92)</td><td>0.93 (0.92, 0.93)</td><td>0.91 (0.91, 0.91)</td></tr><tr><td>1995</td><td>0.91 (0.91, 0.91)</td><td>0.92 (0.92, 0.92)</td><td>0.91 (0.90, 0.91)</td></tr><tr><td> 25&#8211;44 years</td><td></td><td></td><td></td></tr><tr><td>1990</td><td>0.90 (0.90, 0.90)</td><td>0.90 (0.90, 0.91)</td><td>0.89 (0.89, 0.89)</td></tr><tr><td>1995</td><td>0.89 (0.88, 0.89)</td><td>0.9 (0.89, 0.90)</td><td>0.88 (0.88, 0.88)</td></tr><tr><td> 45&#8211;64 years</td><td></td><td></td><td></td></tr><tr><td>1990</td><td>0.82 (0.82, 0.83)</td><td>0.83 (0.82, 0.83)</td><td>0.82 (0.81, 0.82)</td></tr><tr><td>1995</td><td>0.81 (0.81, 0.82)</td><td>0.82 (0.82, 0.83)</td><td>0.81 (0.80, 0.81)</td></tr><tr><td> 65+ years</td><td></td><td></td><td></td></tr><tr><td>1990</td><td>0.73 (0.72, 0.74)</td><td>0.74 (0.74, 0.75)</td><td>0.72 (0.71, 0.73)</td></tr><tr><td>1995</td><td>0.73 (0.72, 0.73)</td><td>0.73 (0.73, 0.74)</td><td>0.72 (0.71, 0.73)</td></tr></table>
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complex
<table><tr><td>Variable</td><td>Proportion %</td><td>N</td></tr><tr><td colspan="3">Membership is a hallmark of professional person</td></tr><tr><td> Agree</td><td>66.9</td><td>99</td></tr><tr><td> Disagree</td><td>33.1</td><td>49</td></tr><tr><td colspan="3">Chiropractic professional associations increase the visibility of the chiropractic profession within the UK</td></tr><tr><td> Yes</td><td>78.4</td><td>116</td></tr><tr><td> No</td><td>21.6</td><td>32</td></tr><tr><td colspan="3">Forgo membership of the existing UK chiropractic associations if a suitable company providing indemnity insurance is available?</td></tr><tr><td> Yes</td><td>35.1</td><td>52</td></tr><tr><td> No</td><td>64.9</td><td>96</td></tr></table>
275654ee7c1364eecb92f1b947ba44611481eb96584df4b87e1038cf7c0c00ac.png
simple
<table><tr><td>Grade</td><td>Evidence levels</td><td>Description</td></tr><tr><td>A</td><td>Ia, Ib</td><td>Requires at least one randomised controlled trial as part of the body of literature of overall good quality and consistency addressing the specific recommendation</td></tr><tr><td>B</td><td>IIa, IIb, III</td><td>Requires availability of well-conducted clinical studies but no randomised clinical trials on the topic of recommendation</td></tr><tr><td>C</td><td>IV</td><td>Requires evidence from expert committee reports or opinions and/or clinical experience of respected authorities. Indicates absence of directly applicable studies of good quality</td></tr></table>