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1e99c0692e90d7ff9be2b92269d502ec1945e3b93c9bb7d9bada29492ecede3a.png	complex	<table><tr><td>Opioids</td><td>Crystalloid</td><td>Colloid</td><td>P value</td></tr><tr><td>Fentanyl (mcg)</td><td>25 (0.0–100)</td><td>25 (0.0–75.0)</td><td>0.52</td></tr><tr><td>Pethidine (mg)</td><td>10.3 (23.7)</td><td>4.9 (16.2)</td><td>0.17</td></tr><tr><td colspan="4">Rescue Anti-emetics</td></tr><tr><td colspan="4">Number of Patients Requiring Rescue</td></tr><tr><td>Anti-emetics N(%)</td><td>9 (16.9)</td><td>5 (5.3)</td><td>0.37</td></tr><tr><td colspan="4">Time of Anti-emetic administration. N (%)</td></tr><tr><td>0–30 min</td><td>2 (3.6)</td><td>3 (5.3)</td><td>0.98</td></tr><tr><td>30 min–2 hrs</td><td>5 (9.1)</td><td>2 (3.5)</td><td>0.42</td></tr><tr><td>2–24 hrs</td><td>3 (5.7)</td><td>0 (0.0)</td><td>0.22</td></tr></table>
0443dfef8e9581ebf0fcb7ae6ab733d17ddb6c8c2b4e5fefae49c9663a3bd220.png	complex	<table><tr><td rowspan="2">Sl. no</td><td rowspan="2">Hydrophobic substrates</td><td colspan="2">Emulsification index (%)</td></tr><tr><td>24 h</td><td>168 h</td></tr><tr><td>1</td><td>n-Hexadecane</td><td>25.19 ± 0.12</td><td>22.58 ± 0.11</td></tr><tr><td>2</td><td>Sunflower oil</td><td>33.33 ± 0.87</td><td>5.26 ± 0.53</td></tr><tr><td>3</td><td>Motor oil</td><td>62.26 ± 0.32</td><td>60.00 ± 0.12</td></tr><tr><td>4</td><td>Diesel</td><td>25.00 ± 0.25</td><td>5.00 ± 0.43</td></tr><tr><td>5</td><td>Crude oil</td><td>100.00 ± 0.32</td><td>83.33 ± 0.23</td></tr></table>
66204a87b77b5b2c1baa09f1266eb4f4236ba33be462f9e540de228e762f3dc2.png	simple	<table><tr><td>Procedure</td><td>Number</td></tr><tr><td>Abdominal aortic aneurysm repair</td><td>1</td></tr><tr><td>Abdominoperineal resection</td><td>1</td></tr><tr><td>Atrial septal defect closure</td><td>2</td></tr><tr><td>Bronchoscopy</td><td>1</td></tr><tr><td>Coronary artery bypass grafting</td><td>2</td></tr><tr><td>Cardiac ablation</td><td>1</td></tr><tr><td>Cardiac catheterization</td><td>3</td></tr><tr><td>Inadvertent air bolus via IV line</td><td>1</td></tr><tr><td>Central vascular access</td><td>9</td></tr><tr><td>Endoscopic Retrograde Cholangio-Pancreatography (ERCP)</td><td>1</td></tr><tr><td>Hysteroscopy</td><td>1</td></tr><tr><td>Laparoscopic liver resection</td><td>2</td></tr><tr><td>Necrotic bowel resection</td><td>1</td></tr><tr><td>Endovascular neurointervention</td><td>2</td></tr><tr><td>Neurosurgery (open procedures)</td><td>11</td></tr><tr><td>Pacemaker placement</td><td>1</td></tr><tr><td>Spinal surgery</td><td>2</td></tr><tr><td>Transarterial chemoembolization (TACE)</td><td>1</td></tr><tr><td>Cardiac valve replacement</td><td>4</td></tr><tr><td>Varicose vein injection</td><td>2</td></tr></table>
ce1b595b74f22e8c7c0cb0eaa2db0e8044d49ede0b85d8ecae8d14e5884ebbcc.png	complex	<table><tr><td></td><td></td><td>Base</td><td>P30</td><td>P60</td></tr><tr><td rowspan="2">Brachial systolic blood pressure (mmHg)</td><td>Before</td><td>117 ± 13</td><td>116 ± 8</td><td>116 ± 8</td></tr><tr><td>After</td><td>117 ± 10</td><td>116 ± 11</td><td>119 ± 12</td></tr><tr><td rowspan="2">Brachial mean arterial blood pressure (mmHg)</td><td>Before</td><td>90 ± 10</td><td>92 ± 9</td><td>92 ± 9</td></tr><tr><td>After</td><td>91 ± 8</td><td>89 ± 9</td><td>92 ± 10</td></tr><tr><td rowspan="2">Brachial diastolic blood pressure (mmHg)</td><td>Before</td><td>73 ± 10</td><td>73 ± 9</td><td>71 ± 7</td></tr><tr><td>After</td><td>70 ± 8</td><td>71 ± 8</td><td>74 ± 9</td></tr><tr><td rowspan="2">Brachial pulse pressure (mmHg)</td><td>Before</td><td>44 ± 8</td><td>43 ± 7</td><td>45 ± 7</td></tr><tr><td>After</td><td>47 ± 7</td><td>45 ± 8</td><td>46 ± 8</td></tr><tr><td rowspan="2">Carotid systolic blood pressure (mmHg)</td><td>Before</td><td>109 ± 5</td><td>107 ± 3</td><td>107 ± 3</td></tr><tr><td>After</td><td>109 ± 4</td><td>106 ± 4</td><td>110 ± 4</td></tr><tr><td rowspan="2">Carotid pulse pressure (mmHg)</td><td>Before</td><td>37 ± 3</td><td>34 ± 2</td><td>36 ± 2</td></tr><tr><td>After</td><td>39 ± 3</td><td>35 ± 2</td><td>36 ± 3</td></tr><tr><td rowspan="2">Heart rate (bpm)</td><td>Before</td><td>58 ± 7</td><td>62 ± 5</td><td>60 ± 5</td></tr><tr><td>After</td><td>56 ± 6</td><td>60 ± 7a</td><td>60 ± 8</td></tr><tr><td rowspan="2"><i>β</i>‐stiffness (U)</td><td>Before</td><td>7.4 ± 3.9</td><td>6.6 ± 3.5</td><td>6.9 ± 4.0</td></tr><tr><td>After</td><td>6.2 ± 3.0b</td><td>5.6 ± 2.8a<sup>,</sup>b</td><td>6.2 ± 2.7</td></tr></table>
0b51b8b6ecce1a6ee0879972ed81a355d651f5730703428576c98c05359b9072.png	simple	<table><tr><td>Climate/geography‡</td><td>PC1</td><td>PC2</td><td>PC3</td><td>DRYWT</td><td>HT</td><td>HEAD</td><td>LFRATIO</td><td>LFCOL</td><td>LFPUB</td><td>HABIT</td><td>AWNS</td><td>GERM</td></tr><tr><td>MAT</td><td>0.08</td><td>−0.20</td><td>0.48</td><td>0.09</td><td>0.09</td><td>−0.40</td><td>0.53</td><td>−0.16</td><td>0.07</td><td>0.05</td><td>−0.18</td><td>0.03</td></tr><tr><td>MWMT</td><td>−0.14</td><td>−0.18</td><td>0.47</td><td>−0.14</td><td>0.00</td><td>−0.40</td><td>0.55</td><td>−0.31</td><td>0.15</td><td>0.14</td><td>−0.32</td><td>0.17</td></tr><tr><td>MCMT</td><td>0.31</td><td>−0.05</td><td>0.31</td><td>0.29</td><td>0.25</td><td>−0.14</td><td>0.29</td><td>0.10</td><td>−0.05</td><td>−0.03</td><td>0.17</td><td>−0.12</td></tr><tr><td>TD</td><td>−0.42</td><td>−0.14</td><td>0.20</td><td>−0.40</td><td>−0.22</td><td>−0.27</td><td>0.30</td><td>−0.40</td><td>0.19</td><td>0.17</td><td>−0.47</td><td>0.27</td></tr><tr><td>MAP</td><td>0.35</td><td>0.19</td><td>−0.47</td><td>0.31</td><td>0.10</td><td>0.15</td><td>−0.48</td><td>0.25</td><td>−0.39</td><td>−0.41</td><td>0.26</td><td>0.06</td></tr><tr><td>MSP</td><td>0.37</td><td>0.19</td><td>−0.50</td><td>0.32</td><td>0.09</td><td>0.18</td><td>−0.51</td><td>0.26</td><td>−0.43</td><td>−0.48</td><td>0.27</td><td>0.00</td></tr><tr><td>AHM</td><td>−0.35</td><td>−0.23</td><td>0.54</td><td>−0.27</td><td>−0.12</td><td>−0.24</td><td>0.63</td><td>−0.32</td><td>0.34</td><td>0.38</td><td>−0.28</td><td>0.02</td></tr><tr><td>SHM</td><td>−0.36</td><td>−0.30</td><td>0.48</td><td>−0.30</td><td>−0.20</td><td>−0.33</td><td>0.58</td><td>−0.32</td><td>0.39</td><td>0.37</td><td>−0.29</td><td>0.04</td></tr><tr><td>FFP</td><td>0.20</td><td>−0.32</td><td>0.18</td><td>0.13</td><td>−0.05</td><td>−0.43</td><td>0.24</td><td>−0.11</td><td>0.04</td><td>−0.22</td><td>−0.20</td><td>−0.06</td></tr><tr><td>PAS</td><td>0.01</td><td>0.20</td><td>−0.53</td><td>−0.01</td><td>−0.07</td><td>0.21</td><td>−0.50</td><td>0.08</td><td>−0.31</td><td>−0.21</td><td>0.13</td><td>0.20</td></tr><tr><td>ELEV</td><td>−0.26</td><td>0.29</td><td>−0.33</td><td>−0.29</td><td>0.04</td><td>0.43</td><td>−0.39</td><td>0.04</td><td>0.00</td><td>0.17</td><td>0.23</td><td>0.07</td></tr><tr><td>LAT</td><td>0.36</td><td>−0.34</td><td>0.00</td><td>0.38</td><td>−0.17</td><td>−0.33</td><td>0.08</td><td>0.15</td><td>−0.01</td><td>−0.38</td><td>−0.20</td><td>−0.24</td></tr><tr><td>LON</td><td>−0.06</td><td>0.03</td><td>−0.14</td><td>−0.08</td><td>−0.01</td><td>−0.10</td><td>−0.18</td><td>−0.11</td><td>−0.18</td><td>−0.13</td><td>−0.22</td><td>0.20</td></tr></table>
836f206753c2e4e62641384064809bf260232a51c0d30a05c8294c1f9cfc661b.png	simple	<table><tr><td></td><td>SCC (n = 395)</td><td>AC (n = 95)</td><td>p-value</td></tr><tr><td>Male</td><td>317(80.3)</td><td>71(74.7)</td><td>0.23</td></tr><tr><td>Age</td><td></td><td></td><td></td></tr><tr><td>< 60</td><td>195(49.4)</td><td>32(33.7)</td><td>0.006</td></tr><tr><td>60-69</td><td>118(29.9)</td><td>26(27.4)</td><td></td></tr><tr><td>70-</td><td>82(20.8)</td><td>37(38.9)</td><td>< 0.0001</td></tr><tr><td>G3+4</td><td>192(48.6)</td><td>61(64.2)</td><td>0.02</td></tr><tr><td>T1-2</td><td>94(25.5)</td><td>17(20.5)</td><td>0.33</td></tr><tr><td>T3</td><td>201(50.9)</td><td>51(53.7)</td><td>n.s.</td></tr><tr><td>T4</td><td>73(18.5)</td><td>15(15.8)</td><td>n.s.</td></tr><tr><td>N+</td><td>198(50.1)</td><td>48(50.5)</td><td>n.s.</td></tr><tr><td>M1</td><td>83(22.0)</td><td>28(32.2)</td><td>0.04</td></tr></table>
5770135ac2be8f0a3fa3f75033901584f4a2c750b353a75f2c2966ad154bc734.png	complex	<table><tr><td rowspan="3"></td><td rowspan="3"></td><td colspan="2"><i>Treatment</i></td><td rowspan="3"><i>P</i></td></tr><tr><td><i>LNG-IUD</i></td><td><i>NETA</i></td></tr><tr><td><i>n (%)</i></td><td><i>n (%)</i></td></tr><tr><td>Initial Mens </td><td>HMB</td><td> 30 (%100)</td><td>30 (%100)</td><td>1,000</td></tr><tr><td rowspan="9">3-6. months Mens</td><td><sup>●</sup> HMB</td><td>2 (%7,1)</td><td>4 (%20)</td><td>0,218</td></tr><tr><td>Spotting</td><td>18 (%64,3)</td><td>6 (%30)</td><td>0,0,019</td></tr><tr><td><sup>●</sup>Amenorrhea</td><td>2 (%7,1)</td><td>1 (%5)</td><td>1,000</td></tr><tr><td>Normal Cycle</td><td>3 (%10,7)</td><td>7 (%35)</td><td>0,041</td></tr><tr><td><sup>●</sup>Oligomenorrhea</td><td>3 (%10,7)</td><td>2 (%10)</td><td>1,000</td></tr><tr><td>HMB Spotting</td><td>1 (%3,7)7 (%25,9)</td><td>5 (%27,8)4 (%22,2)</td><td>0,0310,777</td></tr><tr><td>Amenorrhea</td><td>12 (%44,4)</td><td>1 (%5,6)</td><td>0,006</td></tr><tr><td><sup>●</sup>Normal Cycle</td><td>2 (%7,4)</td><td>6 (%33,3)</td><td>0,045</td></tr><tr><td><sup>●</sup>Oligomenorrhea</td><td>5 (%18,5)</td><td>2 (%11,1)</td><td>0,684</td></tr></table>
1ea2f66d7c7d05d218468f8e4d057433a12fcd1de2efd0e2f38e795c1eb1b5a3.png	complex	<table><tr><td colspan="3">Population</td><td colspan="4">Genomic region</td><td rowspan="2">Number of windows</td><td rowspan="2">Minimum<i>P</i><sub><i>perm</i></sub></td><td rowspan="2">RefSeq genes</td></tr><tr><td>ID</td><td>Name</td><td>Cluster</td><td>Chr</td><td>Begin (bp)</td><td>End (bp)</td><td>Length (bp)</td></tr><tr><td>ITU</td><td>Telugu</td><td>A</td><td>10</td><td>132,953,074</td><td>133,048,305</td><td>95,232</td><td>189</td><td>0.013</td><td><i>TCERG1L</i></td></tr><tr><td>PJL</td><td>Punjabi</td><td>A</td><td>13</td><td>20,001,572</td><td>20,181,691</td><td>180,120</td><td>28</td><td>0.044</td><td><i>TPTE2</i></td></tr></table>
480a2319a5fab0727be5cc3c81710bef7381d7812cfeb99add1f6d4008b28a85.png	simple	<table><tr><td>Component</td><td><i>M. indicus</i></td><td><i>R. oryzae</i></td></tr><tr><td>Biomass (g/L)</td><td>4.7 ± 0.2</td><td>4.0 ± 0.1</td></tr><tr><td>Biomass yield (<i>g</i>/<i>g</i> sugars consumed)</td><td>0.25 ± 0.01</td><td>0.28 ± 0.00</td></tr><tr><td>Protein <sup>1</sup></td><td>0.40 ± 0.01</td><td>0.51 ± 0.07</td></tr><tr><td>Total lipids <sup>1</sup></td><td>0.098 ± 0.011</td><td>0.044 ± 0.007</td></tr><tr><td>AIM <sup>2</sup> yield <sup>1</sup></td><td>0.31 ± 0.01</td><td>0.34 ± 0.01</td></tr></table>
3541167529bd63db2c91cf80ee299ff1deeed9a6e6fce4f43ceff76334a23c52.png	complex	<table><tr><td></td><td colspan="3">Raw meats</td><td colspan="3">Cooked meats</td></tr><tr><td>Fatty acids<sup>A</sup></td><td>DCCOC</td><td>DCCOM</td><td>DCCOH</td><td>DCCOC</td><td>DCCOM</td><td>DCCOH</td></tr><tr><td>MC (%)</td><td>70.7 ± 0.6</td><td>72.0 ± 0.6</td><td>72.3 ± 0.5</td><td>61.6 ± 1.0</td><td>59.7 ± 1.6</td><td>59.4 ± 1.7</td></tr><tr><td>IMF (%)</td><td>3.5 ± 0.4</td><td>3.7 ± 0.6</td><td>2.9 ± 0.3</td><td>5.5 ± 0.6</td><td>5.0 ± 0.6</td><td>4.7 ± 0.6</td></tr><tr><td>∑FA</td><td>3203 ± 379.3</td><td>3421 ± 520.3</td><td>2628 ± 273.6</td><td>5030 ± 591.9</td><td>4565 ± 527.7</td><td>4264 ± 554.7</td></tr><tr><td>14:0</td><td>55.4 ± 10.7</td><td>55.7 ± 12.4</td><td>37.2 ± 5.0</td><td>113.5 ± 21.9</td><td>59.6 ± 11.1</td><td>59.7 ± 7.8</td></tr><tr><td>16:0</td><td>722.6 ± 88.5</td><td>769.4 ± 129.2</td><td>549.1 ± 57.8</td><td>1139.0 ± 129.0</td><td>956.1 ± 116.2</td><td>890.7 ± 119.6</td></tr><tr><td>18.0</td><td>537.2 ± 81.1</td><td>606.6 ± 98.5</td><td>434.7 ± 53.9</td><td>834.5 ± 109.5</td><td>833.6 ± 11.9</td><td>726.7 ± 102.2</td></tr><tr><td>16:1ω7c</td><td>41.0 ± 5.4</td><td>39.6 ± 7.5</td><td>26.9 ± 2.9</td><td>71.6 ± 12.4</td><td>49.2 ± 6.8</td><td>45.5 ± 7.0</td></tr><tr><td>18:1ω9c</td><td>1188 ± 179.2</td><td>1258 ± 205.3</td><td>928.5 ± 106.9</td><td>1880 ± 240.8</td><td>1693 ± 221.7</td><td>1561 ± 210.6</td></tr><tr><td>18:1ω7c</td><td>58.9 ± 5.4</td><td>64.3 ± 8.5</td><td>59.4 ± 4.9</td><td>83.5 ± 8.8</td><td>86.5 ± 9.6</td><td>87.9 ± 13.3</td></tr><tr><td>18:1ω7t</td><td>50.1 ± 8.8</td><td>57.9 ± 12.8</td><td>58.5 ± 7.5</td><td>103.8 ± 26.0</td><td>88.1 ± 14.5</td><td>108.6 ± 16.9</td></tr><tr><td>18:2ω6 (LA)</td><td>148.1 ± 11.2</td><td>182.2 ± 22.1</td><td>165.4 ± 16.8</td><td>221.6 ± 17.9</td><td>256.2 ± 28.0</td><td>231.6 ± 28.3</td></tr><tr><td>18:3ω3 (ALA)</td><td>27.6 ± 4.2</td><td>32.8 ± 4.7</td><td>33.1 ± 4.1</td><td>49.0 ± 9.0</td><td>47.7 ± 5.5</td><td>48.7 ± 7.6</td></tr><tr><td>20:4ω6 (ARA)</td><td>43.8 ± 4.1</td><td>43.0 ± 4.9</td><td>46.8 ± 2.4</td><td>59.2 ± 8.8</td><td>66.5 ± 7.9</td><td>62.7 ± 7.7</td></tr><tr><td>20:5ω3 (EPA)</td><td>17.9 ± 1.6<sup>b</sup></td><td>16.1 ± 1.4<sup>b</sup></td><td>21.0 ± 2.0<sup>a</sup></td><td>21.4 ± 2.2</td><td>24.2 ± 1.8</td><td>28.1 ± 4.0</td></tr><tr><td>22:6ω3 (DHA)</td><td>6.1 ± 1.3</td><td>3.9 ± 0.5</td><td>7.2 ± 0.7</td><td>7.2 ± 0.8</td><td>7.6 ± 0.8</td><td>10.0 ± 1.9</td></tr><tr><td>22:5ω3 (DPA)</td><td>14.2 ± 1.5</td><td>14.2 ± 1.2</td><td>16.3 ± 0.8</td><td>20.7 ± 2.2</td><td>23.5 ± 2.0</td><td>23.2 ± 2.9</td></tr><tr><td>∑SFA</td><td>1453 ± 170.6</td><td>1562 ± 254.9</td><td>1137 ± 130.2</td><td>2292 ± 265.8</td><td>2031 ± 252.2</td><td>1853 ± 242.9</td></tr><tr><td>∑MUFA</td><td>1448 ± 202.1</td><td>1527 ± 246.9</td><td>1164 ± 128.4</td><td>2307 ± 309.8</td><td>2055 ± 267.1</td><td>1951 ± 259.1</td></tr><tr><td>∑PUFA</td><td>301.8 ± 19.2</td><td>331.2 ± 34.5</td><td>326.9 ± 25.5</td><td>430.5 ± 33.3</td><td>479.3 ± 43.7</td><td>460.8 ± 54.9</td></tr><tr><td>∑CLA</td><td>12.8 ± 2.1</td><td>12.5 ± 1.9</td><td>9.7 ± 1.0</td><td>17.6 ± 1.4</td><td>15.9 ± 2.1</td><td>18.1 ± 3.0</td></tr><tr><td>∑ω6</td><td>208.2 ± 14.1</td><td>238.9 ± 27.1</td><td>226.0 ± 19.6</td><td>298.6 ± 26.5</td><td>343.0 ± 36.5</td><td>314.4 ± 36.9</td></tr><tr><td>∑ω3</td><td>70.0 ± 6.0</td><td>69.7 ± 6.4</td><td>80.3 ± 7.1</td><td>101.9 ± 8.7</td><td>106.3 ± 6.2</td><td>113.9 ± 15.4</td></tr><tr><td>EPA + DHA</td><td>24.0 ± 2.9<sup>ab</sup></td><td>20.0 ± 1.6<sup>b</sup></td><td>28.2 ± 2.7<sup>a</sup></td><td>28.6 ± 2.7</td><td>31.7 ± 2.4</td><td>38.1 ± 5.9</td></tr><tr><td>P/S</td><td>0.2 ± 0.0</td><td>0.2 ± 0.0</td><td>0.3 ± 0.0</td><td>0.2 ± 0.0</td><td>0.3 ± 0.0</td><td>0.3 ± 0.0</td></tr><tr><td>6/3</td><td>3.1 ± 0.2</td><td>3.5 ± 0.3</td><td>2.9 ± 0.2</td><td>3.0 ± 0.3</td><td>3.2 ± 0.2</td><td>2.8 ± 0.2</td></tr><tr><td>IA</td><td>0.5 ± 0.0</td><td>0.5 ± 0.0</td><td>0.5 ± 0.0</td><td>0.6 ± 0.0</td><td>0.5 ± 0.0</td><td>0.5 ± 0.0</td></tr><tr><td>IT</td><td>1.2 ± 0.1</td><td>1.3 ± 0.1</td><td>1.1 ± 0.0</td><td>1.3 ± 0.0</td><td>1.2 ± 0.0</td><td>1.1 ± 0.0</td></tr><tr><td>h/H</td><td>1.9 ± 0.1</td><td>2.0 ± 0.1</td><td>2.1 ± 0.0</td><td>1.8 ± 0.1</td><td>2.1 ± 0.1</td><td>2.1 ± 0.1</td></tr></table>
bb2b7adc507b901b216a765957708b959c01c45907c17ff5c193abb4e76fc06e.png	simple	<table><tr><td><i>α</i></td><td><i>EP</i> selection</td><td>Leuk1</td><td>Lung1</td><td>Leuk2</td><td>SRBCT</td><td>Breast</td><td>Lung2</td><td>DLBCL</td><td>Cancers</td><td>GCM</td><td>Average</td></tr><tr><td>No adjustment</td><td>Formula (11)</td><td>94.12</td><td>84.38</td><td>93.33</td><td>95.00</td><td>90.00</td><td>100.00</td><td>90.00</td><td>81.08</td><td>60.87</td><td>87.64</td></tr><tr><td>0.01</td><td>Formula (11)</td><td>94.12</td><td>84.38</td><td>93.33</td><td>100</td><td>90.00</td><td>97.02</td><td>90.00</td><td>90.54</td><td>63.04</td><td>89.16</td></tr><tr><td>0.05</td><td>Formula (11)</td><td>94.12</td><td>84.38</td><td>100</td><td>100</td><td>93.33</td><td>98.51</td><td>90.00</td><td>90.54</td><td>71.74</td><td>91.40</td></tr><tr><td>0.05</td><td>Mean</td><td>94.12</td><td>84.38</td><td>100</td><td>100</td><td>93.33</td><td>97.01</td><td>90.00</td><td>90.54</td><td>71.74</td><td>91.24</td></tr></table>
1fb6775defb21104ee18afd76ea86411f17b38155c9fed95fd8b299de2ff94e5.png	simple	<table><tr><td>Gene (total SNPs)</td><td>SNP</td><td>Minor allele frequency</td><td>BODE score</td><td>Post-BD FEV<sub>1</sub></td><td>Maximum work</td><td>USCD SOBQ score</td></tr><tr><td><i>GSTP1 </i>(7)</td><td>rs6120205' genomic</td><td>0.083</td><td>0.003</td><td></td><td></td><td></td></tr><tr><td></td><td>rs112278843' genomic</td><td>0.073</td><td></td><td>0.003</td><td>0.02</td><td></td></tr><tr><td><i>SFTPB </i>(5)</td><td>--*</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td><i>SERPINE2 </i>(22)</td><td>rs6436449 intron</td><td>0.17</td><td>0.07</td><td></td><td></td><td>0.09</td></tr><tr><td><i>EPHX1 </i>(19)</td><td>rs3753658 promoter</td><td>0.10</td><td>0.008</td><td></td><td></td><td>0.02</td></tr><tr><td></td><td>rs1877724 intron</td><td>0.26</td><td></td><td>0.04</td><td></td><td></td></tr><tr><td></td><td>rs2234922 His139Arg</td><td>0.19</td><td>0.02</td><td></td><td>0.05</td><td></td></tr><tr><td></td><td>rs1051741 exon, synon.</td><td>0.11</td><td>0.09</td><td></td><td>0.01</td><td></td></tr><tr><td></td><td>rs3600633' genomic</td><td>0.38</td><td>0.07</td><td>0.05</td><td></td><td></td></tr><tr><td></td><td>rs22925583' genomic</td><td>0.11</td><td>0.09</td><td></td><td>0.03</td><td></td></tr><tr><td></td><td>rs10096683' genomic</td><td>0.10</td><td></td><td>0.08</td><td></td><td></td></tr><tr><td><i>TGFB1 </i>(11)</td><td>rs2241712 promoter</td><td>0.32</td><td>0.07</td><td></td><td></td><td></td></tr><tr><td></td><td>rs8110090 intron</td><td>0.05</td><td></td><td>0.09</td><td></td><td></td></tr><tr><td></td><td>rs8179181 intron</td><td>0.26</td><td></td><td></td><td>0.06</td><td></td></tr><tr><td></td><td>rs129810533' genomic</td><td>0.15</td><td></td><td>0.06</td><td></td><td></td></tr><tr><td></td><td>rs129809423' genomic</td><td>0.15</td><td></td><td>0.05</td><td></td><td></td></tr></table>
a8934ca51f73bc4da753c73981529e2c989cc2cbcc2e996d6607fb89153f38a7.png	complex	<table><tr><td>Date of DNA extraction</td><td>OTUs</td><td>Abundance (%)</td></tr><tr><td rowspan="7">17 July 2014</td><td><i>Aerococcus</i></td><td>14</td></tr><tr><td>Dermabacteraceae</td><td>12</td></tr><tr><td><i>Micrococcus</i></td><td>10</td></tr><tr><td><i>Enhydrobacter</i></td><td>9</td></tr><tr><td><i>Leuconostoc</i></td><td>6</td></tr><tr><td><i>Kocuria</i></td><td>6</td></tr><tr><td><i>Actinomyces</i></td><td>6</td></tr><tr><td rowspan="3">25 March 2015</td><td><i>Methylobacterium komagatae</i></td><td>65</td></tr><tr><td>Ruminococcaceae</td><td>11</td></tr><tr><td><i>Methylobacterium</i></td><td>6</td></tr><tr><td rowspan="2">26 March 2015</td><td><i>Methylobacterium komagatae</i></td><td>67</td></tr><tr><td><i>Methylobacterium</i></td><td>6</td></tr></table>
da4ea20981348c8e9f118dc25e5fb0d842965e34fbcd89b5c081fb8fb2b649d7.png	complex	<table><tr><td rowspan="2"></td><td>Aboriginal and/or Torres Strait Islander</td><td>Non-Indigenous Australian</td><td rowspan="2">P value</td></tr><tr><td>N = 174</td><td>N = 1210</td></tr><tr><td>Age (years)</td><td>37.4</td><td>65.1</td><td rowspan="2"><0.001</td></tr><tr><td>(Median (IQR))</td><td>(26.9 – 49.1)</td><td>(55.5 – 72.8)</td></tr><tr><td>Sex (% female)</td><td>67.2</td><td>64.0</td><td rowspan="2">0.411</td></tr><tr><td>(95% CI)</td><td>(59.7 – 74.2)</td><td>(61.3 – 66.8)</td></tr><tr><td>Concomitant CABG</td><td>9.8</td><td>22.9</td><td rowspan="2"><0.001</td></tr><tr><td>(%, 95% CI)</td><td>(5.8 – 15.2)</td><td>(20.6 – 25.4)</td></tr><tr><td>Area of residence</td><td></td><td></td><td></td></tr><tr><td>Remote and very remote</td><td>54.1</td><td>1.6</td><td rowspan="2"><0.001</td></tr><tr><td>(% RA category 3 & 4, 95% CI)</td><td>(46.3 – 61.7)</td><td>(1.0 – 2.4)</td></tr><tr><td>Inner and outer regional</td><td>39.5</td><td>33.3</td><td rowspan="2">0.108</td></tr><tr><td>(% RA category 1 & 2, 95% CI)</td><td>(32.2 – 47.3)</td><td>(30.7 – 36.1)</td></tr><tr><td>Major city</td><td>6.4</td><td>65.1</td><td rowspan="2"><0.001</td></tr><tr><td>(%, 95% CI)</td><td>(3.2 – 11.2)</td><td>(62.3 – 67.8)</td></tr><tr><td>Pre-surgery comorbidities</td><td></td><td></td><td></td></tr><tr><td>Diabetes</td><td>24.3</td><td>19.8</td><td rowspan="2">0.167</td></tr><tr><td>(%, 95% CI)</td><td>(18.1 – 31.4)</td><td>(17.5 – 22.1)</td></tr><tr><td>Elevated Creatinine</td><td>2.9</td><td>2.7</td><td rowspan="2">0.912</td></tr><tr><td>(% Cr > =200 μmol/L) (95% CI)</td><td>(0.9 – 6.6)</td><td>(1.9 – 3.8)</td></tr><tr><td>Chronic kidney disease (% eGFR < 60 mL/min/1.73 m<sup>2</sup>)</td><td>14.4</td><td>33.5</td><td rowspan="2"><0.001</td></tr><tr><td>(95% CI)</td><td>(9.5 – 20.5)</td><td>(30.8 – 36.2)</td></tr><tr><td>Hypertension</td><td>37.0</td><td>55.3</td><td rowspan="2"><0.001</td></tr><tr><td>(%, 95% CI)</td><td>(29.8 – 44.7)</td><td>(52.4 – 58.1)</td></tr><tr><td>Previous smoking</td><td>64.2</td><td>51.0</td><td rowspan="2"><0.001</td></tr><tr><td>(%, 95% CI)</td><td>(56.5 – 71.3)</td><td>(48.2 – 53.9)</td></tr><tr><td>Current smoking</td><td>55.4</td><td>19.7</td><td rowspan="2"><0.001</td></tr><tr><td>(%, 95% CI)</td><td>(45.7 – 64.8)</td><td>(16.7 – 23.1)</td></tr><tr><td>Pre-operative status</td><td></td><td></td><td></td></tr><tr><td>NYHA classes III & IV</td><td>47.1</td><td>53.1</td><td rowspan="2">0.138</td></tr><tr><td>(%, 95% CI)</td><td>(39.5 – 54.8)</td><td>(50.3 – 56.0)</td></tr><tr><td>Atrial fibrillation</td><td>33.3</td><td>41.6</td><td rowspan="2">0.039</td></tr><tr><td>(%, 95% CI)</td><td>(26.4 – 40.9)</td><td>(38.8 – 44.4)</td></tr><tr><td>LVEF >45%</td><td>83.9</td><td>84.7</td><td rowspan="2">0.784</td></tr><tr><td>(%, 95% CI)</td><td>(77.6 – 89.0)</td><td>(82.6 – 86.7)</td></tr><tr><td>LVEF 30 – 45%</td><td>11.5</td><td>10.8</td><td rowspan="2">0.792</td></tr><tr><td>(%, 95% CI)</td><td>(7.2 – 17.2)</td><td>(9.1 – 12.7)</td></tr><tr><td>LVEF <30%</td><td>3.4</td><td>2.1</td><td rowspan="2">0.249</td></tr><tr><td>(%, 95% CI)</td><td>(1.3 – 7.4)</td><td>(1.3 – 3.1)</td></tr><tr><td>Previous procedures</td><td></td><td></td><td></td></tr><tr><td>Valve surgery</td><td>16.1</td><td>13.1</td><td rowspan="2">0.287</td></tr><tr><td>(%, 95% CI)</td><td>(11.0 – 22.4)</td><td>(11.3 – 15.2)</td></tr><tr><td>PBV</td><td>29.5</td><td>19.5</td><td rowspan="2">0.124</td></tr><tr><td>(%, 95% CI)</td><td>(16.8 – 45.2)</td><td>(15.3 – 24.3)</td></tr></table>
035389cdd96d892eaf072068f93e476fbb0c545fb99dacd8789aa31cd31cb5c6.png	complex	<table><tr><td></td><td></td><td colspan="3">Diabetic children</td><td colspan="2">School children</td><td></td><td></td><td></td></tr><tr><td>Scale</td><td>No.items</td><td colspan="3"></td><td colspan="2"></td><td>F</td><td>d.f</td><td>p-value</td></tr><tr><td></td><td></td><td>n</td><td>mean ± SD</td><td>α</td><td>n</td><td>mean ± SD</td><td></td><td></td><td></td></tr><tr><td>PedsQLTM 4.0 Generic</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Core Scales</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td><i>Child self-report</i></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Total score</td><td>23</td><td>94</td><td>67.98 ± 14.03</td><td>0.87</td><td>200</td><td>78.21+13.23</td><td>33.33</td><td>(1,292)</td><td>< 0.001</td></tr><tr><td>Physical health</td><td>8</td><td>94</td><td>69.18 ± 17.05</td><td>0.77</td><td>200</td><td>80.06+15.02</td><td>29.34</td><td>(1,292)</td><td>< 0.001</td></tr><tr><td>Emotional functioning</td><td>5</td><td>94</td><td>59.84 ± 20.41</td><td>0.71</td><td>200</td><td>69.17+19.60</td><td>13.93</td><td>(1,292)</td><td>< 0.001</td></tr><tr><td>Social functioning</td><td>5</td><td>94</td><td>76.78 ± 18.19</td><td>0.73</td><td>200</td><td>78.62+18.25</td><td>1.69</td><td>(1,292)</td><td>0.194</td></tr><tr><td>School functioning</td><td>5</td><td>94</td><td>65.79 ± 18.23</td><td>0.73</td><td>200</td><td>83.90+16.59</td><td>52.54</td><td>(1,292)</td><td>< 0.001</td></tr><tr><td>Psychosocial health</td><td>15</td><td>94</td><td>67.34 ± 14.72</td><td>0.82</td><td>200</td><td>77.23+14.36</td><td>26.15</td><td>(1,292)</td><td>< 0.001</td></tr><tr><td><i>Parent proxy-report</i></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Total score</td><td>23</td><td>94</td><td>67.03 ± 12.83</td><td>0.83</td><td>200</td><td>74.79+16.22</td><td>14.91</td><td>(1,292)</td><td>< 0.001</td></tr><tr><td>Physical health</td><td>8</td><td>94</td><td>67.42 ± 16.50</td><td>0.73</td><td>200</td><td>76.00+20.11</td><td>12.03</td><td>(1,292)</td><td>0.001</td></tr><tr><td>Emotional functioning</td><td>5</td><td>94</td><td>58.63 ± 18.48</td><td>0.73</td><td>200</td><td>68.02+21.09</td><td>16.37</td><td>(1,292)</td><td>< 0.001</td></tr><tr><td>Social functioning</td><td>5</td><td>94</td><td>75.16 ± 18.63</td><td>0.71</td><td>200</td><td>81.30+20.90</td><td>2.99</td><td>(1,292)</td><td>0.085</td></tr><tr><td>School functioning</td><td>5</td><td>94</td><td>66.65 ± 19.24</td><td>0.72</td><td>200</td><td>73.12+20.68</td><td>5.61</td><td>(1,292)</td><td>0.019</td></tr><tr><td>Psychosocial health</td><td>15</td><td>94</td><td>66.81 ± 13.81</td><td>0.79</td><td>200</td><td>74.15+16.59</td><td>12.13</td><td>(1,292)</td><td>0.001</td></tr><tr><td>PedsQLTM 3.0 Diabetic</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Module</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td><i>Child self-report</i></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Diabetes symptoms</td><td>11</td><td>94</td><td>59.21 ± 14.46</td><td>0.74</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Treatment barriers</td><td>4</td><td>94</td><td>58.38 ± 21.51</td><td>0.67</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Treatment adherence</td><td>7</td><td>94</td><td>60.18 ± 18.12</td><td>0.78</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Worry</td><td>3</td><td>94</td><td>56.47 ± 23.35</td><td>0.71</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Communication</td><td>3</td><td>94</td><td>61.08 ± 27.34</td><td>0.76</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td><i>Parent proxy-report</i></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Diabetes symptoms</td><td>11</td><td>94</td><td>58.57 ± 13.62</td><td>0.73</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Treatment barriers</td><td>4</td><td>94</td><td>53.53 ± 21.03</td><td>0.68</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Treatment adherence</td><td>7</td><td>94</td><td>57.60 ± 15.99</td><td>0.71</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Worry</td><td>3</td><td>94</td><td>56.91 ± 23.01</td><td>0.72</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Communication</td><td>3</td><td>94</td><td>60.99 ± 25.69</td><td>0.70</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td></tr></table>
16d4f5c51e6b25350bc32b15875f27fb59b5848354974788a4de91c938ff3084.png	simple	<table><tr><td></td><td>Overall Injury Risk (RP1) <sup>1</sup></td><td>Ankle Injury Severity (RP2) <sup>1</sup></td><td>Knee Injury Severity (RP3) <sup>1</sup></td><td>Injuries Are Preventable (OE1) <sup>2</sup></td><td>FIFA 11+ Prevents Injuries (OE2) <sup>2</sup></td><td>I Understand the FIFA 11+ (TSE1) <sup>3</sup></td><td>I Can Use the FIFA 11+ (TSE2) <sup>3</sup></td><td>Intention to Use the FIFA 11+ (INT) <sup>4</sup></td></tr><tr><td>RP1</td><td>1.00</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td>RP2</td><td>0.68 </td><td>1.00</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td>RP3</td><td>0.80 </td><td>0.79 </td><td>1.00</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td>OE1</td><td>0.70 </td><td>0.74 </td><td>0.78 </td><td>1.00</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td>OE2</td><td>−0.34</td><td>0.06</td><td>−0.16</td><td>−0.18</td><td>1.00</td><td>-</td><td>-</td><td>-</td></tr><tr><td>TSE1</td><td>0.17</td><td>0.17</td><td>0.53</td><td>0.00</td><td>−0.25</td><td>1.00</td><td>-</td><td>-</td></tr><tr><td>TSE2</td><td>0.06</td><td>0.18</td><td>0.46</td><td>−0.07</td><td>−0.13</td><td>0.96 </td><td>1.00</td><td>-</td></tr><tr><td>INT</td><td>0.09</td><td>0.13</td><td>0.55</td><td>0.13</td><td>−0.24</td><td>0.84 </td><td>0.89 *</td><td>1.00</td></tr></table>
7691e4f85608a5d643419ac5716f32306e0b82c02460bfb69f1e066b78a9c61d.png	simple	<table><tr><td> </td><td>Number of patients</td><td>Percentage</td></tr><tr><td>OCD Group</td><td>135</td><td>75.4%</td></tr><tr><td>Non-OCD anxiety disorders group</td><td>44</td><td>24.6%</td></tr></table>
1b71195b62bc35fa7c6a6a7d92ee25414b0428c2f5791960fbc60cb71dbc784a.png	simple	<table><tr><td>Rupintrivir concn (μM) at final passage or control treatment</td><td>Clone no.</td><td>Mean EC<sub>50</sub> ± SD<sup><i>a</i></sup> (μM)</td><td>Fold change in sensitivity<sup><i>b</i></sup></td><td>Amino acid substitution(s) in protease</td></tr><tr><td>20</td><td>1</td><td>14.3 ± 1.7</td><td>10.9</td><td>A105V/I109V</td></tr><tr><td></td><td>2</td><td>12.3 ± 1.2</td><td>9.4</td><td>A105V/I109V</td></tr><tr><td></td><td>3</td><td>15.3 ± 1.1</td><td>11.7</td><td>A105V/I109V</td></tr><tr><td>15</td><td>1</td><td>8.5 ± 1.9</td><td>6.5</td><td>A105V/I109V</td></tr><tr><td></td><td>2</td><td>14.3 ± 1.3</td><td>10.9</td><td>A105V/I109V</td></tr><tr><td></td><td>3</td><td>6.9 ± 1.7</td><td>5.3</td><td>I109V</td></tr><tr><td>10</td><td>1</td><td>6.6 ± 2.4</td><td>5.0</td><td>I109V</td></tr><tr><td></td><td>2</td><td>6.3 ± 2.3</td><td>4.8</td><td>I109V</td></tr><tr><td></td><td>3</td><td>5.9 ± 1.3</td><td>4.5</td><td>I109V</td></tr><tr><td>DMSO</td><td></td><td>1.3 ± 0.2</td><td>1.0</td><td></td></tr></table>
b60866271a26a0c303dffdcad1a13c7050029f8b7431fdb171292c5190fb7a6b.png	complex	<table><tr><td rowspan="2">Variable</td><td rowspan="2">Number (%)</td><td colspan="2">BAI<sup>a</sup> score n (%)</td><td rowspan="2"><i>p</i>-value<sup>*</sup></td></tr><tr><td><22</td><td>≥22</td></tr><tr><td>Age (years)</td><td></td><td></td><td></td><td>0.493</td></tr><tr><td> 10–19</td><td>208(18.2)</td><td>174(83.7)</td><td>34(16.3)</td><td></td></tr><tr><td> 20–29</td><td>858(75.2)</td><td>727(84.7)</td><td>131(15.3)</td><td></td></tr><tr><td>≥ 30</td><td>75(6.6)</td><td>67(89.3)</td><td>8(10.7)</td><td></td></tr><tr><td>Body mass index (Kg/m<sup>2</sup>)</td><td></td><td></td><td></td><td>0.718</td></tr><tr><td>< 25.0</td><td>986(86.4)</td><td>838(85.0)</td><td>148(15.0)</td><td></td></tr><tr><td>≥ 25.0</td><td>155(13.6)</td><td>130(83.9)</td><td>25(16.1)</td><td></td></tr><tr><td>Marital status</td><td></td><td></td><td></td><td>0.481</td></tr><tr><td> Unmarried</td><td>1018(89.2)</td><td>861(84.6)</td><td>157(15.4)</td><td></td></tr><tr><td> Married</td><td>123(10.8)</td><td>107(87.0)</td><td>16(13.0)</td><td></td></tr><tr><td>Educational level</td><td></td><td></td><td></td><td>0.655</td></tr><tr><td>≤ high school</td><td>882(77.3)</td><td>746(84.6)</td><td>136(15.4)</td><td></td></tr><tr><td>≥ college</td><td>259(22.7)</td><td>222(85.7)</td><td>37(14.3)</td><td></td></tr><tr><td>Smoking habit</td><td></td><td></td><td></td><td>0.014</td></tr><tr><td> Non-smoker</td><td>769(67.4)</td><td>669(87.0)</td><td>100(13.0)</td><td></td></tr><tr><td> Ex-smoker</td><td>146(12.8)</td><td>117(80.1)</td><td>29(19.9)</td><td></td></tr><tr><td> Current smoker</td><td>226(19.8)</td><td>182(80.5)</td><td>44(19.5)</td><td></td></tr><tr><td>Risky drinking<sup>b</sup></td><td></td><td></td><td></td><td>0.006</td></tr><tr><td> No</td><td>935(81.9)</td><td>806(86.2)</td><td>129(13.8)</td><td></td></tr><tr><td> Yes</td><td>206(18.1)</td><td>162(78.6)</td><td>44(21.2)</td><td></td></tr><tr><td>Regular exercise</td><td></td><td></td><td></td><td>0.674</td></tr><tr><td>< 3 times per week</td><td>904(79.2)</td><td>769(79.4)</td><td>135(78.0)</td><td></td></tr><tr><td>≥ 3 times per week</td><td>237(20.8)</td><td>199(20.6)</td><td>38(22.0)</td><td></td></tr><tr><td>Shift work</td><td></td><td></td><td></td><td>0.145</td></tr><tr><td> No</td><td>75(6.5)</td><td>68(90.7)</td><td>7(9.3)</td><td></td></tr><tr><td> Yes</td><td>1066(93.5)</td><td>900(84.4)</td><td>166(15.6)</td><td></td></tr><tr><td>Job tenure (years)</td><td></td><td></td><td></td><td>0.306</td></tr><tr><td>< 1</td><td>274(24.0)</td><td>232(84.7)</td><td>42(15.3)</td><td></td></tr><tr><td> 1–3</td><td>286(25.1)</td><td>237(82.9)</td><td>49(17.1)</td><td></td></tr><tr><td> 4–6</td><td>273(23.9)</td><td>228(83.5)</td><td>45(16.5)</td><td></td></tr><tr><td>≥ 7</td><td>308(27.0)</td><td>271(88.0)</td><td>37(12.0)</td><td></td></tr><tr><td>PSQI<sup>c</sup> score</td><td></td><td></td><td></td><td><0.001</td></tr><tr><td>< 6</td><td>450(39.4)</td><td>421(93.6)</td><td>29(6.4)</td><td></td></tr><tr><td>≥ 6</td><td>691(60.6)</td><td>547(79.2)</td><td>144(20.8)</td><td></td></tr></table>
e6a0fa769c9661c6021c2d7067ed55f7613e9998be7df4e38d4709cf9634175b.png	simple	<table><tr><td>Type</td><td>% Miss in positive</td><td>% Miss in random</td></tr><tr><td>All features</td><td>83%</td><td>85%</td></tr><tr><td>Gene expression</td><td>15–27%</td><td>24–43%</td></tr><tr><td>GO</td><td>39–66%</td><td>40–54%</td></tr></table>
aabbe9c9bbd02c7ba40d85e23f626d244c387faea4c99a65cf6b3d68ab6ce4d6.png	simple	<table><tr><td>Barriers to carrying out PU</td><td>Risk assessment number (%)</td><td>Documentation number (%)</td><td>Prevention number (%)</td></tr><tr><td>Total number of respondents</td><td>194 (100)</td><td>194 (100)</td><td>194 (100)</td></tr><tr><td>Lack of time</td><td>32 (23.7)</td><td>46 (34.1)</td><td>33 (24.4)</td></tr><tr><td>Unstable patient</td><td>17 (12.6)</td><td>16 (11.9)</td><td>24 (17.8)</td></tr><tr><td>Lack of training, resources, equipment, guidelines</td><td>26 (19.3)</td><td>0 (0)</td><td>22 (16.3)</td></tr><tr><td>Short staffed</td><td>33 (24.4)</td><td>30 (22.2)</td><td>20 (14.8)</td></tr><tr><td>Lack of knowledge</td><td>13 (9.6)</td><td>14 (10.4)</td><td>19 (14.1)</td></tr><tr><td>Lack of aids</td><td>0 (0)</td><td>15 (11.1)</td><td>14 (10.4)</td></tr><tr><td>Unable to assess</td><td>9 (6.7)</td><td>0 (0)</td><td>13 (9.6)</td></tr><tr><td>Problem with assessment tool</td><td>9 (6.7)</td><td>21 (15.6)</td><td>0 (0)</td></tr><tr><td>Forget</td><td>0 (0)</td><td>13 (9.6)</td><td>0 (0)</td></tr><tr><td>Lack of equipment</td><td>18 (13.3)</td><td>10 (7.4)</td><td>0 (0)</td></tr><tr><td>Patient un-cooperative/too ill</td><td>20 (14.8)</td><td>0 (0)</td><td>0 (0)</td></tr></table>
3f5fdb3d8711e72b8a4ea67fdbfed16a0b11b30128d8d981e5a3dbfac3cf7b03.png	complex	<table><tr><td rowspan="2">Label</td><td rowspan="2">Volume</td><td rowspan="2"><i>t</i>-value</td><td colspan="3">Peak activation (LPI)</td></tr><tr><td>x</td><td>y</td><td>z</td></tr><tr><td>Left Thalamus</td><td>342</td><td>3.92</td><td>-9</td><td>6</td><td>12</td></tr><tr><td>Right Inferior Parietal Lobule</td><td>208</td><td>3.67</td><td>57</td><td>−57</td><td>39</td></tr><tr><td>Left Superior Medial Gyrus</td><td>184</td><td>3.65</td><td>3</td><td>36</td><td>42</td></tr><tr><td>Left Precuneus</td><td>179</td><td>3.59</td><td>3</td><td>−69</td><td>48</td></tr><tr><td>Right Middle Frontal Gyrus</td><td>137</td><td>3.64</td><td>33</td><td>15</td><td>60</td></tr><tr><td>Left Angular Gyrus</td><td>113</td><td>3.51</td><td>−57</td><td>−54</td><td>30</td></tr><tr><td>Left Middle Frontal Gyrus</td><td>96</td><td>3.69</td><td>−24</td><td>15</td><td>60</td></tr><tr><td>Left Middle Frontal Gyrus</td><td>90</td><td>3.48</td><td>−45</td><td>51</td><td>-3</td></tr></table>
5838fa17a8a376a074ea40341781a3fc7ddd8e03f0b8577524104104fdbd0636.png	simple	<table><tr><td>Sites</td><td>Gender</td><td>L<sub>t</sub>(cm)</td><td>L<sub>f</sub>(cm)</td><td>W<sub>t</sub>(g)</td><td>W<sub>g</sub>(g)</td><td>GSI</td></tr><tr><td>Reference (A1)</td><td>Female</td><td>29.85 ± 2.72</td><td>26.29 ± 2.98</td><td>283.45 ± 57.34</td><td>7.936 ± 0.361</td><td>2.68 ± 0.26</td></tr><tr><td></td><td>Male</td><td>28.85 ± 2.81</td><td>27.29 ± 2.21</td><td>281.25 ± 37.54</td><td>5.434 ± 0.251</td><td>1.58 ± 0.12</td></tr><tr><td>Harbor (A2)</td><td>Female</td><td>20.88 ± 3.22</td><td>19.45 ± 2.74</td><td>108.50 ± 77.90</td><td>0.629 ± 0.447</td><td>0.08 ± 0.063</td></tr><tr><td></td><td>Male</td><td>18.28 ± 8.72</td><td>16.25 ± 2.92</td><td>105.31 ± 55.60</td><td>0.129 ± 0.047</td><td>0.02 ± 0.013</td></tr></table>
49f431fa15909bd5203de7f7fb0c3856ad4f5efaaf910df9d4a9cbaedaa66e44.png	complex	<table><tr><td rowspan="2">Characteristic</td><td colspan="3">Prevalence</td><td colspan="3">Incidence</td></tr><tr><td>No.</td><td>%</td><td>Weighted<sup>a</sup> (%)</td><td>No.</td><td>%</td><td>Weighted<sup>a</sup> (%)</td></tr><tr><td colspan="7">Age group</td></tr><tr><td>0–24</td><td>160,382</td><td>26.9</td><td>33.8</td><td>166,840</td><td>28.0</td><td>34.7</td></tr><tr><td>25–34</td><td>91,435</td><td>15.3</td><td>14.9</td><td>89,597</td><td>15.0</td><td>15.1</td></tr><tr><td>35–44</td><td>99,582</td><td>16.7</td><td>18.3</td><td>102,999</td><td>17.3</td><td>18.5</td></tr><tr><td>45–54</td><td>93,763</td><td>15.7</td><td>13.9</td><td>90,667</td><td>15.2</td><td>13.4</td></tr><tr><td>55–64</td><td>80,155</td><td>13.4</td><td>10.5</td><td>78,075</td><td>13.1</td><td>10.2</td></tr><tr><td>65–74</td><td>44,840</td><td>7.5</td><td>5.5</td><td>43,245</td><td>7.3</td><td>5.3</td></tr><tr><td>75–84</td><td>22,200</td><td>3.7</td><td>2.6</td><td>20,585</td><td>3.5</td><td>2.4</td></tr><tr><td>≥85</td><td>4,179</td><td>0.7</td><td>0.5</td><td>3,703</td><td>0.6</td><td>0.4</td></tr><tr><td colspan="7">Sex</td></tr><tr><td>Men</td><td>300,192</td><td>50.3</td><td>51.1</td><td>299,725</td><td>50.3</td><td>51.1</td></tr><tr><td>Women</td><td>296,344</td><td>49.7</td><td>48.9</td><td>295,986</td><td>49.7</td><td>48.9</td></tr><tr><td colspan="7">Ethnicity</td></tr><tr><td>Han</td><td>521,343</td><td>87.4</td><td>91.8</td><td>518,151</td><td>87.0</td><td>91.4</td></tr><tr><td>Other</td><td>75,193</td><td>12.6</td><td>8.2</td><td>77,560</td><td>13.0</td><td>8.6</td></tr><tr><td colspan="7">Education, <i>n</i> (%)</td></tr><tr><td>Primary school</td><td>248,916</td><td>41.7</td><td>39.6</td><td>245,192</td><td>41.2</td><td>38.9</td></tr><tr><td>Middle school</td><td>294,209</td><td>49.3</td><td>49.0</td><td>294,193</td><td>49.4</td><td>49.2</td></tr><tr><td>College and higher</td><td>51,730</td><td>8.7</td><td>11.2</td><td>51,721</td><td>8.7</td><td>11.3</td></tr><tr><td>Missing</td><td>1,681</td><td>0.3</td><td>0.2</td><td>4,605</td><td>0.8</td><td>0.5</td></tr><tr><td colspan="7">Marital status, <i>n</i> (%)</td></tr><tr><td>Married</td><td>391,160</td><td>65.6</td><td>60.9</td><td>391,124</td><td>65.7</td><td>61.2</td></tr><tr><td>Single</td><td>116,817</td><td>19.6</td><td>24.0</td><td>115,438</td><td>19.4</td><td>23.8</td></tr><tr><td>Widowed</td><td>32,734</td><td>5.5</td><td>4.2</td><td>32,731</td><td>5.5</td><td>4.2</td></tr><tr><td>Other</td><td>53,735</td><td>9.0</td><td>10.6</td><td>51,402</td><td>8.6</td><td>10.2</td></tr><tr><td>Missing</td><td>2,090</td><td>0.4</td><td>0.2</td><td>5,016</td><td>0.8</td><td>0.6</td></tr><tr><td colspan="7">Occupation, <i>n</i> (%)</td></tr><tr><td>Students</td><td>108,978</td><td>18.3</td><td>23.1</td><td>105,510</td><td>17.7</td><td>22.4</td></tr><tr><td>Worker</td><td>45,021</td><td>7.5</td><td>8.7</td><td>45,004</td><td>7.6</td><td>8.8</td></tr><tr><td>Farmer</td><td>271,068</td><td>45.4</td><td>38.6</td><td>270,916</td><td>45.5</td><td>38.8</td></tr><tr><td>Employee</td><td>46,676</td><td>7.8</td><td>9.8</td><td>46,674</td><td>7.8</td><td>9.9</td></tr><tr><td>Entrepreneurs</td><td>52,518</td><td>8.8</td><td>10.2</td><td>52,516</td><td>8.8</td><td>10.2</td></tr><tr><td>Retiree or homemaker</td><td>66,169</td><td>11.1</td><td>8.7</td><td>66,145</td><td>11.1</td><td>8.7</td></tr><tr><td>other</td><td>4,439</td><td>0.7</td><td>0.7</td><td>4,356</td><td>0.7</td><td>0.7</td></tr><tr><td>Missing</td><td>1,667</td><td>0.3</td><td>0.2</td><td>4,590</td><td>0.8</td><td>0.5</td></tr><tr><td colspan="7">Place of residence</td></tr><tr><td>Urban</td><td>248,570</td><td>47.4</td><td>52.9</td><td>248,090</td><td>47.4</td><td>52.8</td></tr><tr><td>Rural</td><td>347,966</td><td>52.6</td><td>47.1</td><td>347,621</td><td>52.6</td><td>47.2</td></tr><tr><td colspan="7">Geographic location</td></tr><tr><td>Eastern China</td><td>201,354</td><td>33.8</td><td>40.7</td><td>201,196</td><td>33.8</td><td>40.7</td></tr><tr><td>Central China</td><td>239,735</td><td>40.2</td><td>32.0</td><td>239,288</td><td>40.2</td><td>32.0</td></tr><tr><td>Western China</td><td>155,447</td><td>26.1</td><td>27.3</td><td>155,227</td><td>26.1</td><td>27.3</td></tr></table>
767b2d5b381c7fb306c1393e699fce1a7058393db9515ee18364c998c912b9c9.png	complex	<table><tr><td rowspan="2">HPV genotype</td><td colspan="4">Age (Years)Frequency (%)</td><td rowspan="2">Total Frequency (%)</td></tr><tr><td>< 40</td><td>40–49</td><td>50–59</td><td>> 60</td></tr><tr><td>6</td><td>0 (0%)</td><td>0 (0%)</td><td>1 (100.0%)</td><td>0 (0%)</td><td>1 (100%)</td></tr><tr><td>16</td><td>7 (6.3%)</td><td>27 (24.3%)</td><td>42 (37.9%)</td><td>35 (31.5%)</td><td>111 (100%)</td></tr><tr><td>18</td><td>1 (4.5%)</td><td>7 (31.8%)</td><td>6 (27.3%)</td><td>8 (36.4%)</td><td>22 (100%)</td></tr><tr><td>31</td><td>0 (0%)</td><td>1 (50.0%)</td><td>0 (0%)</td><td>1 (50.0%)</td><td>2 (100%)</td></tr><tr><td>33</td><td>0 (0%)</td><td>1 (25.0%)</td><td>0 (0%)</td><td>3 (75.0%)</td><td>4 (100%)</td></tr><tr><td>35</td><td>0 (0%)</td><td>1 (50.0%)</td><td>1 (50.0%)</td><td>0 (0%)</td><td>2 (100%)</td></tr><tr><td>39</td><td>0 (0%)</td><td>0 (0%)</td><td>0 (0%)</td><td>1 (100.0%)</td><td>1 (100%)</td></tr><tr><td>45</td><td>0 (0%)</td><td>2 (33.3%)</td><td>2 (33.3%)</td><td>2 (33.3%)</td><td>6 (100%)</td></tr><tr><td>52</td><td>1 (50.0%)</td><td>0 (0%)</td><td>0 (0%)</td><td>1 (50.0%)</td><td>2 (100%)</td></tr><tr><td>56</td><td>0 (0%)</td><td>0 (0%)</td><td>2 (50.0%)</td><td>2 (50.0%)</td><td>4 (100%)</td></tr><tr><td>68</td><td>0 (0%)</td><td>0 (0%)</td><td>1 (100.0%)</td><td>0 (0%)</td><td>1 (100%)</td></tr><tr><td>16 + 18</td><td>1 (33.3%)</td><td>0 (0%)</td><td>1 (33.3%)</td><td>1 (33.3%)</td><td>3 (100%)</td></tr><tr><td>16 + 39</td><td>0 (0%)</td><td>0 (0%)</td><td>0 (0%)</td><td>1 (100.0%)</td><td>1 (100%)</td></tr><tr><td>16 + 45</td><td>0 (0%)</td><td>0 (0%)</td><td>2 (100.0%)</td><td>0 (0%)</td><td>2 (100%)</td></tr><tr><td>16 + 51</td><td>0 (0%)</td><td>0 (0%)</td><td>1 (100.0%)</td><td>0 (0%)</td><td>1 (100%)</td></tr><tr><td>16 + 52</td><td>0 (0%)</td><td>1 (0%)</td><td>0 (0%)</td><td>0 (0%)</td><td>1 (100%)</td></tr><tr><td>31 + 52</td><td>0 (0%)</td><td>1 (0%)</td><td>0 (0%)</td><td>0 (0%)</td><td>1 (100%)</td></tr></table>
fd890d57bec65f27c901a27b47cc3852d5ac03ab22c9010e644f7d64475237f6.png	simple	<table><tr><td>Variables</td><td>Resource</td><td>Year</td><td>Operating institution</td></tr><tr><td>The number of general hospitals (per 100,000 persons)</td><td>Survey of Medical Institutions,</td><td>2002</td><td>Ministry of Health, Labor and welfare</td></tr><tr><td>The number of beds in hospital (per 100,000 persons)</td><td>Hospital Report</td><td>2002</td><td>Ministry of Health, Labor and welfare</td></tr><tr><td>Ratio of daily occupied beds in general hospital</td><td>Hospital Report</td><td>2002</td><td>Ministry of Health, Labor and welfare</td></tr><tr><td>The number of families in which the elderly were living alone (per 100 households with person 65 years or older)</td><td>Population Census</td><td>2002</td><td>Ministry of Public Management, Home Affairs, Posts and Telecommunications</td></tr><tr><td>Dwelling rooms (per dwelling)</td><td>Population Census</td><td>2002</td><td>Ministry of Public Management, Home Affairs, Posts and Telecommunications</td></tr><tr><td>Health service facilities for the elderly (per 100,000 persons 65 years old and over)</td><td>Survey of Institutions and Establishment for long-term care</td><td>2002</td><td>Ministry of Health, Labor and welfare</td></tr></table>
2b8100702e771dc0c4a47c870f453c5dd57da7e982ec8e80d57dee5d2e0ec864.png	simple	<table><tr><td>Data set name</td><td>Number of patients</td><td>Microarray type</td><td>Outcome</td></tr><tr><td>Chin [72]</td><td>130</td><td>Affymetrix GeneChip Human Genome U133A Array Set</td><td>Disease specific survival (Event = death from breast cancer)</td></tr><tr><td>Miller [73]</td><td>251</td><td>Affymetrix GeneChip Human Genome U133 Array Set</td><td>Disease specific survival (Event = death from breast cancer)</td></tr><tr><td>Pittman [74]</td><td>158</td><td>Affymetrix GeneChip Human Genome U95av2 Array Set</td><td>Overall survival (Even t = death from breast cancer)</td></tr></table>
240d199d1770abd0c569ac864b45ef05767037db137e281f45dea299bb6d99eb.png	simple	<table><tr><td></td><td>B</td><td>Se</td></tr><tr><td>Intercept</td><td>0.23</td><td>0.16</td></tr><tr><td>Quality aspects:</td><td></td><td></td></tr><tr><td> Total quality score</td><td>0.75</td><td>0.19</td></tr><tr><td> Adjustment for confounders at study level</td><td>-2.34</td><td>0.81</td></tr><tr><td> Culturally adjusted questionnaire</td><td>-1.83</td><td>0.52</td></tr><tr><td>Study characteristics:</td><td></td><td></td></tr><tr><td> Country US</td><td>1.67</td><td>0.60</td></tr><tr><td> Publication year</td><td>-0.00</td><td>0.04</td></tr><tr><td> Adjustment confounders outcome level</td><td>-0.00</td><td>0.41</td></tr><tr><td> Sample size majority reference group</td><td>0.00</td><td>0.00</td></tr><tr><td> Sample size immigrant groups</td><td>-0.00</td><td>0.00</td></tr><tr><td> Length of reference period of use</td><td>-0.15</td><td>0.26</td></tr><tr><td> Background immigrant groups <sup>a</sup></td><td></td><td></td></tr><tr><td>European</td><td>1.69</td><td>0.92</td></tr><tr><td>African</td><td>0.14</td><td>0.77</td></tr><tr><td>Asian</td><td>0.92</td><td>0.56</td></tr><tr><td>(South/central) American</td><td>0.23</td><td>0.60</td></tr><tr><td>Variance study level<sup>b</sup></td><td>0</td><td>0</td></tr><tr><td>Variance outcome level</td><td>0.92</td><td>0.09</td></tr></table>
b4e16ef7b4c7eac776e6d07ad90c495cd776c4a89af997b52361ba8fee5bb5c2.png	simple	<table><tr><td>Impact Category-</td><td>Group 1</td><td>Group 2</td><td>Group 3</td><td>Group 4</td><td>Group 5</td><td>Group 6</td></tr><tr><td>Non-renewable, fossil</td><td>0.224</td><td>0.219</td><td>0.215</td><td>0.212</td><td>0.207</td><td>0.198</td></tr><tr><td>Renewable, biomass</td><td>1.04</td><td>1.04</td><td>1.04</td><td>1.04</td><td>1.04</td><td>1.04</td></tr><tr><td>*Others</td><td>0.012</td><td>0.012</td><td>0.012</td><td>0.012</td><td>0.011</td><td>0.011</td></tr><tr><td>Total</td><td>1.28</td><td>1.27</td><td>1.27</td><td>1.26</td><td>1.26</td><td>1.25</td></tr></table>
12705bb2554428da651b54c4ffcac707631b91b256d793394d4c9b06fb1d73c6.png	complex	<table><tr><td rowspan="2">Sample no.</td><td colspan="2">TDS (mg/L)</td><td colspan="2">pH</td><td colspan="2">Conductivity (Ds/m)</td></tr><tr><td>Before desalination</td><td>After desalination</td><td>Before desalination</td><td>After desalination</td><td>Before desalination</td><td>After desalination</td></tr><tr><td>Sample A-B</td><td>320</td><td>40</td><td>7.60</td><td>7.32</td><td>1</td><td>0.10</td></tr></table>
bdb9f50e2fff631f9175846485a68fa0e5bdbac5824097cc090243ccca2426ec.png	simple	<table><tr><td>Active ROM Excursion</td><td>Dominant arm</td><td>Non Dominant arm</td><td> </td></tr><tr><td> </td><td>MSD</td><td>MSD</td><td>P-value</td></tr><tr><td>CAD (cm)</td><td>25.38 ± 3.67</td><td>24.70 ± 3.56</td><td><0.001</td></tr><tr><td>FLX (°)</td><td>165.56 ± 7.76</td><td>164.52 ± 9.33</td><td><0.001</td></tr><tr><td>ER0 (°)</td><td>76.46 ± 11.98</td><td>74.56 ± 11.65</td><td><0.001</td></tr><tr><td>IR 90° Abduction (°)</td><td>54.72 ± 13.35</td><td>58.35 ± 11.96</td><td><0.001</td></tr><tr><td>ER 90° Abduction (°)</td><td>98.81 ± 10.88</td><td>95.30 ± 10.15</td><td><0.001</td></tr><tr><td>ARC (°)</td><td>153.53 ± 16.47</td><td>153.65 ± 14.58</td><td>0.804</td></tr><tr><td>Passive ROM Excursion</td><td>Dominant arm</td><td>Non Dominant arm</td><td> </td></tr><tr><td> </td><td>MSD</td><td>MSD</td><td>P-value</td></tr><tr><td>CAD (cm)</td><td>23.31 ± 3.49</td><td>22.59 ± 3.42</td><td><0.001</td></tr><tr><td>FLX (°)</td><td>170.55 ± 7.68</td><td>169.79 ± 9.44</td><td>0.009</td></tr><tr><td>ER0 (°)</td><td>82.28 ± 12.34</td><td>80.48 ± 11.73</td><td><0.001</td></tr><tr><td>IR 90° Abduction (°)</td><td>58.91 ± 14.04</td><td>62.43 ± 12.80</td><td><0.001</td></tr><tr><td>ER 90° Abduction (°)</td><td>104.64 ± 10.83</td><td>100.55 ± 9.81</td><td>< 0.001</td></tr><tr><td>ARC (°)</td><td>163.56 ± 17.41</td><td>162.99 ± 15.65</td><td>0.251</td></tr></table>
c95fd35f00e0b5ced7f2f7cb5f788a6da44f7fe5f266969fb80faf6c5361e0e7.png	complex	<table><tr><td>PFAS <i>n </i>= 1,566</td><td>Men (<i>n </i>= 956) β (95% CI)</td><td>All women (<i>n </i>= 958) β (95% CI)</td><td>Premenopausal women (<i>n </i>= 590) β (95% CI)</td><td>Postmenopausal women (<i>n </i>= 368) β (95% CI)</td></tr><tr><td>PFOA</td></tr><tr><td>Q1</td><td>Referent</td><td>Referent</td><td>Referent</td><td>Referent</td></tr><tr><td>Q2</td><td>0.011 (–0.021, 0.043)</td><td>–0.025 (–0.052, 0.002)</td><td>–0.028 (–0.060, 0.003)</td><td> –0.022 (–0.077, 0.033)</td></tr><tr><td>Q3</td><td>–0.013 (–0.053, 0.028)</td><td>–0.002 (–0.039, 0.034)</td><td>0.014 (–0.031, 0.060)</td><td>–0.024 (–0.083, 0.035)</td></tr><tr><td>Q4</td><td>0.004 (–0.035, 0.043)</td><td>–0.028 (–0.058, 0.001)</td><td>–0.019 (–0.056, 0.018)</td><td>–0.041 (–0.098, 0.016)</td></tr><tr><td>ln-PFOA</td><td>0.001 (–0.025, 0.022)</td><td>–0.017 (–0.033, –0.001)</td><td>–0.012 (–0.030, 0.007)</td><td>0.020 (–0.049, 0.010)</td></tr><tr><td>PFOS</td></tr><tr><td>Q1</td><td>Referent</td><td>Referent</td><td>Referent</td><td>Referent</td></tr><tr><td>Q2</td><td>–0.036 (–0.077, 0.006)</td><td>0.001(–0.019, 0.019)</td><td>–0.005 (–0.028, 0.018)</td><td>–0.005 (0.087, 0.077)</td></tr><tr><td>Q3</td><td>–0.027 (–0.063, 0.009)</td><td>–0.001 (–0.025, 0.025)</td><td>–0.005 (–0.028, 0.017)</td><td>–0.001 (–0.082, 0.080)</td></tr><tr><td>Q4</td><td>–0.046 (–0.078, –0.015)</td><td>–0.034 (–0.059, –0.009)</td><td>–0.001 (–0.029, 0.029)</td><td>–0.062 (0.134, 0.009)</td></tr><tr><td>ln-PFOS</td><td>–0.013 (–0.024, –0.002)</td><td>–0.016(–0.029, –0.002)</td><td>–0.001 (–0.015, 0.015)</td><td>–0.033 (–0.049, –0.017)</td></tr><tr><td>PFHxS</td></tr><tr><td>Q1</td><td>Referent</td><td>Referent</td><td>Referent</td><td>Referent</td></tr><tr><td>Q2</td><td>–0.002 (–0.042, 0.038)</td><td>–0.008 (–0.039, 0.023)</td><td>–0.004 (–0.042, 0.033)</td><td>–0.025 (–0.100, 0.050)</td></tr><tr><td>Q3</td><td>–0.004 (–0.031, 0.023)</td><td>0.001 (–0.025, 0.027)</td><td>0.010 (–0.018, 0.038)</td><td>–0.017 (–0.092, 0.058)</td></tr><tr><td>Q4</td><td>–0.013 (–0.052, 0.025)</td><td>–0.018 (–0.051, 0.016)</td><td>–0.010 (–0.039, 0.018)</td><td>–0.026 (–0.104, 0.051)</td></tr><tr><td>ln-PFHxS</td><td>–0.009 (–0.024, 0.006)</td><td>–0.005 (–0.018, 0.008)</td><td>–0.001 (–0.015, 0.013)</td><td>–0.005 (–0.024, 0.013)</td></tr><tr><td>PFNA</td></tr><tr><td>Q1</td><td>Referent</td><td>Referent</td><td>Referent</td><td>Referent</td></tr><tr><td>Q2</td><td>–0.010 (–0.058, 0.037)</td><td>–0.020 (–0.066, 0.027)</td><td>–0.023 (–0.073, 0.027)</td><td>–0.013 (–0.087, 0.060)</td></tr><tr><td>Q3</td><td>–0.004 (–0.035, 0.028)</td><td>–0.001 (–0.029, 0.029)</td><td>0.001 (–0.035, 0.038)</td><td>–0.009 (–0.078, 0.060)</td></tr><tr><td>Q4</td><td>0.009 (–0.022, 0.039)</td><td>–0.023 (–0.051, 0.005)</td><td>–0.005 (–0.049, 0.040)</td><td>–0.046 (–0.103, 0.012)</td></tr><tr><td>ln-PFNA</td><td>–0.005 (–0.021, 0.018)</td><td>–0.014 (–0.032, 0.003)</td><td>–0.005 (–0.025, 0.016)</td><td>–0.025 (–0.049, –0.001)</td></tr><tr><td colspan="5"><sup><i>a</i></sup>Adjusted for age (continuous) and age categories (12–20, 21–50, ≥ 50 years), ethnicity, BMI, serum cotinine, physical activity, milk consumption, and blood lead concentration.</td></tr></table>
17a086cd0b0a74148c4cbf14918564ec30f86b2b0646b1c4366399a680ccca46.png	complex	<table><tr><td></td><td colspan="3">Smoking status</td><td colspan="3">GOLD stage</td><td colspan="3">H. influenzae</td></tr><tr><td></td><td>Current smoker n = 15</td><td>Ex-smoker n = 29</td><td>p</td><td>II n = 15</td><td>III+IV n = 29</td><td>p</td><td>No n-12</td><td>Yes = n = 12</td><td>p*</td></tr><tr><td><i>IL-6(pg/ml)</i></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>induced</td><td>17.2(5.7-36.2)</td><td>16.7(4.0-43.2)</td><td>0.63</td><td>16.7(4.5-67.8)</td><td>19.4(5.2-36.2)</td><td>0.78</td><td>20.7(10.9-49.0)</td><td>17.8(1.3-28.6)</td><td>0.16</td></tr><tr><td>spontaneous</td><td>10.2(3.0-29.5)</td><td>21.5(5.8-48.2)</td><td>0.22</td><td>15.6(2.2-64.9)</td><td>13.8(4.45.8)</td><td>0.79</td><td>32.2(22.4-75.38)</td><td>12.0(2.6-18.8)</td><td>0.01</td></tr><tr><td><i>IL-8(pg/ml)</i></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>induced</td><td>505.4(161.3-805.9)</td><td>517.0(193.3-1257.2)</td><td>0.54</td><td>233.4(170.0-1257.2)</td><td>529.0(224.5-1156.0)</td><td>0.37</td><td>277.6(170.0-649.0)</td><td>655.49(274.70-832.70)</td><td>0.32</td></tr><tr><td>spontaneous</td><td>221.0(165.4-674.4)</td><td>405.0(173.2-891.8)</td><td>0.42</td><td>210.1(112.7-844.1)</td><td>546.3(174.7-891.8)</td><td>0.18</td><td>336.9(210.1-734.2)</td><td>570.4(265.8-1141.4)</td><td>0.23</td></tr><tr><td><i>IP-10(pg/ml)</i></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>induced</td><td>216.5(130.9-826.2)</td><td>624.3(289.9-1844.9)</td><td>0.08</td><td>232.5(175.2-748.3)</td><td>600.8(216.7-1844.9)</td><td>0.20</td><td>477.5(175.2-2554.8)</td><td>696.1(56.0-1574.1)</td><td>0.85</td></tr><tr><td>spontaneous</td><td>345.6(124.9-716.5)</td><td>461.0(237.5-1361.7)</td><td>0.14</td><td>354.5(129.7-780.1)</td><td>448(237.5-1202.0)</td><td>0.33</td><td>491.9(285.2-2269.7)</td><td>582.7(180.0-1093.0)</td><td>0.42</td></tr><tr><td><i>TNF-</i>α<i>(pg/ml)</i></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>induced</td><td>0.4(0-1.9)</td><td>1.5(0-4.8)</td><td>0.34</td><td>0.00(0.00-2.5)</td><td>1.6(0-4.2)</td><td>0.14</td><td>2.3(0.0-5.1)</td><td>3.2(0.7-24.3)</td><td>0.24</td></tr><tr><td>spontaneous</td><td>0.9(0-3.2)</td><td>3.3(0.3-7.4)</td><td>0.20</td><td>0.5(0.0-4.5)</td><td>2.4(0.8-7.4)</td><td>0.18</td><td>6.43.7-14.0</td><td>7.9(2.1-173.9)</td><td>0.69</td></tr><tr><td><i>IL-18(pg/ml)</i></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>induced</td><td>9.0(0.9-19.3)</td><td>8.4(4.1-25.6)</td><td>0.58</td><td>10.6(2.4-14.9)</td><td>6.3(4.1-25.6)</td><td>0.91</td><td>5.04(0.0-13.6)</td><td>4.2(0.6-10.1)</td><td>1.0</td></tr><tr><td>spontaneous</td><td>2.9(0.5-14.8)</td><td>14.8(8.3-31.7)</td><td>0.01</td><td>8.8(1.0-15.1)</td><td>14.6(3.5-29.8)</td><td>0.24</td><td>10.4(5.0-13.9)</td><td>7.0(2.7-25.2)</td><td>0.45</td></tr><tr><td><i>MIG(pg/ml)</i></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>induced</td><td>332.2(30.1-661.7)</td><td>806.3(110.5-1391.4)</td><td>0.15</td><td>121.8(41.2-897.0)</td><td>661.7(110.5-1314.3)</td><td>0.27</td><td>157.8(43.3-1714.8)</td><td>677.1(179.0-961.8)</td><td>0.54</td></tr><tr><td>spontaneous</td><td>208.5(31.7-385.8)</td><td>626.8(222.6-2031.7)</td><td>0.03</td><td>280.4(69.8-1537.1)</td><td>383.4(205.3-1941.6)</td><td>0.47</td><td>1473.0 (438.8-4392.9)</td><td>740.5(384.6-2088.3)</td><td>0.33</td></tr></table>
115d3e6d8fa12cf5d954cdae9e713f4f5e2aaa7486cc7b93d830013c784a2b58.png	simple	<table><tr><td>Hemodynamic variable</td><td>T0</td><td>T1</td><td>T2</td><td>p value</td></tr><tr><td>HR, beats.min<sup>−1</sup></td><td>96 (72,5 to 105.5)</td><td>93 (71.5 to 103.5)</td><td>91.5 (72.5 to 102.5)</td><td>0.067</td></tr><tr><td>PAM, mmHg</td><td>76.5 (71 to 83,6)</td><td>85 (76 to 90.5)<sup>a,b</sup></td><td>81 (72.5 to 92)</td><td><0.001</td></tr><tr><td>PAPm, mmHg</td><td>25 (21 to 27)</td><td>28 (26 to 30)<sup>a,b</sup></td><td>26 (24 to 29)<sup>c</sup></td><td><0.001</td></tr><tr><td>PCWP, mmHg</td><td>12 (9.5 to 14)</td><td>14 (12 to 17)<sup>a,b</sup></td><td>14 (10 to 14.2)</td><td><0.001</td></tr><tr><td>CVP, mmHg</td><td>10 (7.7 to 11.2)</td><td>12 (9.7 to 13)<sup>a,b</sup></td><td>10 (8 to 11)</td><td><0.001</td></tr><tr><td>CI, l.min<sup>−2</sup>.m<sup>−2</sup></td><td>3.4 ± 0.9</td><td>3.9 ± 0.9<sup>a,b</sup></td><td>3.5 ± 1.0</td><td><0.001</td></tr><tr><td>SVRI, dyn.sec.cm<sup>−5</sup> m<sup>2</sup></td><td>1,576 (1,390 to 1,966)</td><td>1,427 (1,229 to 1,867)<sup>a</sup></td><td>1,555 (1,290 to 2,229)</td><td>0.013</td></tr><tr><td>PVRI, dyn.sec.cm<sup>−5</sup> m<sup>2</sup></td><td>311 (241 to 375)</td><td>262 (225 to 319)<sup>a</sup></td><td>302 (265 to 403)<sup>c</sup></td><td><0.001</td></tr><tr><td>SvO<sub>2</sub>,%</td><td>71 (67.8 to 78.6)</td><td>73.1 (68.1 to 78.8)</td><td>71.9 (68.1 to 78.4)</td><td>0.356</td></tr><tr><td>D (A-v)O<sub>2</sub>, mL/dL</td><td>3.5 (3.0 to 4.0)</td><td>3.3 (2.7 to 3.8)<sup>a</sup></td><td>3.3 (2.9 to 3.9)</td><td>0.043</td></tr><tr><td>DO<sub>2</sub>, mL.m<sup>−1</sup>.m<sup>−2</sup></td><td>450 ± 127</td><td>489 ± 125<sup>a,b</sup></td><td>456 ± 137</td><td><0.001</td></tr><tr><td>VO<sub>2</sub>, mL.m<sup>−1</sup>.m<sup>−2</sup></td><td>118 ± 28</td><td>126 ± 29<sup>a</sup></td><td>116 ± 31</td><td>0.03</td></tr><tr><td>Lactate, mmol.L</td><td>1.9 (1.2 to 2.4)</td><td>1.55 (1.05 to 2.45)<sup>a,b</sup></td><td>1.95 (1.15 to 2.27)</td><td>0.002</td></tr><tr><td>Hb, g/dL</td><td>10 (8.8 to 10,9)</td><td>8.9 (8.1 to 10.5)<sup>a</sup></td><td>9.6 (8.6 to 10.9)<sup>c</sup></td><td><0.001</td></tr><tr><td>VTIAo, cm</td><td>18.3 ± 3.62</td><td>21.21 ± 4.49<sup>a,b</sup></td><td>20.4 ± 4.63</td><td><0.001*</td></tr><tr><td>E/A</td><td>1.05 ± 0.27</td><td>1.1 ± 0.31</td><td>1.11 ± 0.3</td><td>0.232</td></tr><tr><td>E/e’</td><td>5.17 (4.36 to 6.42)</td><td>6.27 (4.24 to 6.7)</td><td>5.65 (4.82 to 7.35)</td><td>0.657</td></tr><tr><td>Qva/Qt</td><td>25.3 (22.5 to 33)</td><td>26 (22.2 to 32.6)</td><td>27.5 (22.5 to 32.6)</td><td>0.307</td></tr></table>
b35996e6734601a9dc9e133e835c06429c0bcf7b2d26835493dab5ca939e1ced.png	simple	<table><tr><td>Strategy</td><td>Life time Cost $</td><td>Life time incremental cost$</td><td>Life years gain</td><td>Incremental life years gain</td><td>Cost effectiveness ($)</td><td>Incremental Cost Effectiveness ratio (ICER $)</td><td>% change from base case ICER</td></tr><tr><td><i>Undiscounted</i></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>no-ART</td><td>265(86–1148)</td><td></td><td>2.3(1.95–2.73)</td><td></td><td>114(38–504)</td><td></td><td></td></tr><tr><td>ART</td><td>2479(1214–4828)</td><td>2215(771–4635)</td><td>9.4(8.67–10.05)</td><td>7.1(6.24–7.83)</td><td>265(130–513)</td><td>314(111–654)</td><td></td></tr><tr><td><i>Discounted at 3%</i></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>no-ART</td><td>247(80–1008)</td><td></td><td>2.2(1.83–2.56)</td><td></td><td>114(37–471)</td><td></td><td></td></tr><tr><td>ART</td><td>2028(1000–3868)</td><td>1780(577–3710)</td><td>7.7(7.15–8.18)</td><td>5.5(4.85–6.13)</td><td>265(131–508)</td><td>325(106–680)</td><td>3.5</td></tr></table>
f93da99ad7e66dfc2e7a417f82d11fc7d95872f6b1b07729de210f9a6f01973e.png	complex	<table><tr><td rowspan="2"></td><td colspan="2">eGFR</td><td colspan="2">Urinary protein</td><td colspan="2">Systolic blood pressure</td></tr><tr><td>B</td><td><i>p</i> value</td><td>B</td><td><i>p</i> value</td><td>B*</td><td><i>p</i> value</td></tr><tr><td colspan="7"><i>Complement system components</i></td></tr><tr><td>Complement C1q subcomponent subunit C</td><td>−</td><td>0.3</td><td>+</td><td>0.2</td><td>+</td><td>0.5</td></tr><tr><td>Complement C1r subcomponent</td><td>−</td><td>0.003</td><td>+</td><td>0.5</td><td>+</td><td>0.02</td></tr><tr><td>Complement C1s subcomponent</td><td>−</td><td>0.005</td><td>+</td><td>0.7</td><td>+</td><td>0.003</td></tr><tr><td>Complement C3</td><td>−</td><td>0.3</td><td>−</td><td>0.5</td><td>+</td><td>0.2</td></tr><tr><td>Complement C4-B</td><td>−</td><td>0.2</td><td>+</td><td>0.9</td><td>+</td><td>0.05</td></tr><tr><td>Complement C5</td><td>−</td><td>0.04</td><td>−</td><td>0.3</td><td>+</td><td>0.02</td></tr><tr><td>Complement C6</td><td>−</td><td>0.03</td><td>−</td><td>0.3</td><td>+</td><td>0.09</td></tr><tr><td>Complement C7</td><td>−</td><td>0.06</td><td>−</td><td>0.5</td><td>+</td><td>0.2</td></tr><tr><td>Complement C8 alpha chain</td><td>−</td><td>0.03</td><td>−</td><td>0.4</td><td>+</td><td>0.05</td></tr><tr><td>Complement C8 beta chain</td><td>−</td><td>0.02</td><td>−</td><td>0.2</td><td>+</td><td>0.004</td></tr><tr><td>Complement C8 gamma chain</td><td>−</td><td>0.1</td><td>+</td><td>0.6</td><td>+</td><td>0.4</td></tr><tr><td>Complement C9</td><td>−</td><td>0.01</td><td>−</td><td>0.24</td><td>+</td><td>0.01</td></tr><tr><td colspan="7"><i>Complement system regulators</i></td></tr><tr><td>Clusterin</td><td>−</td><td>0.02</td><td>−</td><td>0.3</td><td>+</td><td>0.1</td></tr><tr><td>Complement factor H</td><td>−</td><td>0.1</td><td>−</td><td>0.5</td><td>+</td><td>0.02</td></tr><tr><td>Complement factor H-related protein 1</td><td>−</td><td>0. 4</td><td>−</td><td>0.8</td><td>+</td><td>0.1</td></tr><tr><td>Complement factor H-related protein 2</td><td>+</td><td>0.9</td><td>−</td><td>0.9</td><td>+</td><td>0.5</td></tr><tr><td>Complement factor H-related protein 5</td><td>−</td><td>0.3</td><td>−</td><td>0.5</td><td>+</td><td>0.5</td></tr><tr><td>Complement receptor type 1</td><td>+</td><td>0.07</td><td>+</td><td>0.9</td><td>−</td><td>0.4</td></tr><tr><td>C4b-binding protein alpha chain</td><td>−</td><td>0.06</td><td>−</td><td>0.4</td><td>+</td><td><0.001</td></tr></table>
b273f692e0720e8688fed0c54de4c556cf400d4864bfec3ab2d19502861d1a8a.png	complex	<table><tr><td></td><td>Total number of isolates N = 973</td><td>Proportion of T2 isolates n (%)</td><td colspan="2">Univariate analysis</td><td colspan="2">Multivariable analysis</td></tr><tr><td>Zone</td><td></td><td></td><td>*OR (95% CI)</td><td>p-value</td><td>OR (95% CI)</td><td>p-value</td></tr><tr><td>South West</td><td>313</td><td>172 (55.0)</td><td>Ref.</td><td></td><td>Ref.</td><td></td></tr><tr><td>Kampala</td><td>278</td><td>112 (40.3)</td><td>1.9 (1.34-2.79)</td><td>0.004</td><td>1.8 (1.23-2.53)</td><td>0.005</td></tr><tr><td>Eastern</td><td>89</td><td>22 (23.6)</td><td>1.9 (0.76-4.79)</td><td>1.57</td><td>1.9 (0.8-4.43)</td><td>0.122</td></tr><tr><td>South East</td><td>36</td><td>7 (19.4)</td><td>1.7 (1.26-2.35)</td><td>0.001</td><td>1.8 (1.25-2.62)</td><td>0.003</td></tr><tr><td>North East</td><td>59</td><td>28 (44.1)</td><td>1.9 (1.27-2.73)</td><td>0.030</td><td>1.8 (1.23-2.53)</td><td>0.001</td></tr><tr><td>North</td><td>28</td><td>10 (35.7)</td><td>0.8 (0.58-1.08)</td><td>0.137</td><td>1.0 (0.69-1.45)</td><td>0.980</td></tr><tr><td>North West</td><td>66</td><td>20 (30.3)</td><td>0.5 (0.27-1.10)</td><td>0.295</td><td>0.73 (2.05-2.78)</td><td>0.113</td></tr><tr><td>Western</td><td>104</td><td>53 (51.0)</td><td>1.5 (0.22-1.61)</td><td>0.134</td><td>1.6 (0.89-2.78)</td><td>0.546</td></tr></table>
38cffea20ddf92e1d9d16b10ee22a68f59c26dd708ed203e76dda7d1af25441d.png	complex	<table><tr><td rowspan="2">Phase</td><td colspan="2">Normothermia</td><td colspan="2">Hypothermia</td><td colspan="2">Mortality</td></tr><tr><td>Male</td><td>Female</td><td>Male</td><td>Female</td><td>Total</td><td><i>n</i></td></tr><tr><td>1</td><td>23</td><td>20</td><td></td><td></td><td>7 (14%)</td><td>43</td></tr><tr><td>2</td><td>14</td><td>17</td><td>15</td><td>16</td><td>2 (3%)<sup>a</sup></td><td>62</td></tr><tr><td>3</td><td>3</td><td>4</td><td>3</td><td>5</td><td>1 (6.25%)</td><td>15</td></tr></table>
b0c075871bae4bc471c881eecec3bcabe08374796de333c4cc999598b79d295e.png	complex	<table><tr><td></td><td colspan="3">Skewed Distributions</td><td colspan="3">Approximately Symmetric Distributions</td></tr><tr><td>Number of Factors</td><td>1</td><td>2</td><td>3</td><td>1</td><td>2</td><td>3</td></tr><tr><td>China</td><td>993</td><td>7</td><td>0</td><td>0</td><td>1000</td><td>0</td></tr><tr><td>India</td><td>62</td><td>938</td><td>0</td><td>0</td><td>932</td><td>18</td></tr><tr><td>Mexico</td><td>894</td><td>106</td><td>0</td><td>0</td><td>1000</td><td>0</td></tr><tr><td>Russian Federation</td><td>6</td><td>994</td><td>0</td><td>0</td><td>1000</td><td>0</td></tr><tr><td>South Africa</td><td>1000</td><td>0</td><td>0</td><td>0</td><td>396</td><td>604</td></tr><tr><td>Ghana</td><td>587</td><td>413</td><td>0</td><td>0</td><td>0</td><td>1000</td></tr></table>
0bd2e05c4bc3a38993f4645bbb00ffe0555480053ae1e6e08e665beaf55a099e.png	simple	<table><tr><td>Property</td><td>Clarified Juice</td><td>UV Treatment</td></tr><tr><td>pH</td><td>3.74 ± 0.01 <sup>a</sup></td><td>3.54 ± 0.03 <sup>b</sup></td></tr><tr><td>Malic acid eq. (mg/mL)</td><td>6.19 ± 0.04 <sup>a</sup></td><td>6.06 ± 0.04 <sup>a</sup></td></tr><tr><td>°Brix</td><td>17.97 ± 0.06 <sup>a</sup></td><td>18.05 ± 0.07 <sup>a</sup></td></tr><tr><td>Ascorbic acid (ppm)</td><td>119.22 ± 5.04 <sup>a</sup></td><td>121.16 ± 0.75 <sup>a</sup></td></tr><tr><td>TEAC (mM)</td><td>10.99 ± 0.16 <sup>a</sup></td><td>9.85 ± 0.96 <sup>c</sup></td></tr><tr><td>Gallic acid eq. (mg/L)</td><td>343.17 ± 1.02 <sup>a</sup></td><td>346.02 ± 5.04 <sup>a</sup></td></tr><tr><td>Hue</td><td>81.37 ± 0.59 <sup>a</sup></td><td>87.57 ± 0.51 <sup>b</sup></td></tr><tr><td>Chroma</td><td>3.29 ± 1.21 <sup>a</sup></td><td>5.10 ± 1.32 <sup>a</sup></td></tr></table>
33728b963aedca2d071dbc4c4c476f89014117ef596864212cdc6bf0a10f80ce.png	simple	<table><tr><td></td><td>Time Between Ultrasound and MRI</td><td>PC VIPR Pressure (mmHg)</td><td>Ultrasound Pressure (mmHg)</td><td>Stenosis (%)</td></tr><tr><td>No Repair</td><td>7 days</td><td>16.3</td><td>42*</td><td>32.8</td></tr><tr><td></td><td>5 months</td><td>32.3</td><td>33.8</td><td>26.2</td></tr><tr><td></td><td>6 days</td><td>16.3</td><td>23.4</td><td>18.4</td></tr><tr><td>Post Repair</td><td>17 months</td><td>5.5</td><td>0</td><td>11.1</td></tr><tr><td></td><td>1 month</td><td>6.6</td><td>0</td><td>6.9</td></tr><tr><td></td><td>3 months</td><td>26.6</td><td>35.1</td><td>30.1</td></tr><tr><td></td><td>2 years</td><td>-1.6</td><td>0</td><td>24.8</td></tr></table>
7ccc5187c5fd2dc65ac619656e8daea565ce4b99713bf11d38f1ceffa2704eb2.png	simple	<table><tr><td></td><td>Training set (n = 86)</td><td>Validation set (n = 42)</td></tr><tr><td>Error rate (%)</td><td>9.1</td><td>16.7</td></tr><tr><td>Sensitivity (%)</td><td>97.5</td><td>93.3</td></tr><tr><td>Specificity (%)</td><td>74.8</td><td>58.3</td></tr><tr><td>AUC</td><td>0.93</td><td>0.89</td></tr></table>
cd286a99134ba4b6172ce7e7a8f0e5fa0941668f3f2f5964932bc8adfd6e8125.png	complex	<table><tr><td>Name</td><td>Function</td><td>Primer Sequence (5' to 3')</td><td>Tm (°C)</td><td>Product Length</td><td>Amplified Region</td></tr><tr><td rowspan="2">SIRT2</td><td rowspan="2">RT-PCR</td><td>CAACCTGGAGAAATACCGTCTT</td><td rowspan="2">61.0</td><td rowspan="2">166 bp</td><td rowspan="2">400–565</td></tr><tr><td>CAGTCCTTTTTCCTTCAGCAG</td></tr><tr><td rowspan="2">β-actin</td><td rowspan="2">Reference</td><td>CACCAACTGGGACGACAT</td><td rowspan="2">61.0</td><td rowspan="2">202 bp</td><td rowspan="2">320–521</td></tr><tr><td>ATACAGGGACAGCACAGC</td></tr><tr><td rowspan="2">RPS9</td><td rowspan="2">Reference</td><td>CCTCGACCAAGAGCTGAAG</td><td rowspan="2">61.0</td><td rowspan="2">64 bp</td><td rowspan="2">128–191</td></tr><tr><td>CCTCCAGACCTCACGTTTGTTC</td></tr><tr><td rowspan="2">GAPDH</td><td rowspan="2">Reference</td><td>CCAACGTGTCTGTTGTGGAT</td><td rowspan="2">61.0</td><td rowspan="2">80 bp</td><td rowspan="2">778–857</td></tr><tr><td>CTGCTTCACCACCTTCTTGA</td></tr><tr><td rowspan="2">Primer A</td><td rowspan="2">3'UTR region amplification</td><td>ACCCCTGACCTCACCAAAT</td><td rowspan="2">56.5</td><td rowspan="2">549 bp</td><td rowspan="2">19411–19959</td></tr><tr><td>GCACCTTTCAGCACTCTTC</td></tr><tr><td rowspan="2">Primer B</td><td rowspan="2">3'UTR region amplification</td><td>ACCCCTGACCTCACCAAAT</td><td rowspan="2">62.3</td><td rowspan="2">138 bp</td><td rowspan="2">19411–19548</td></tr><tr><td>CCTGTGGCCCCCTGAGCAGTTAGAGTCTAG</td></tr></table>
d613e0d8f1d15a30164412287f7bb5eed7ab61980d39ed4f4e404a29a32e1cec.png	simple	<table><tr><td>Data set name</td><td>Description</td></tr><tr><td>LIVER CANCER [46]</td><td>Microarrays: 181; Probes: 6,605; <i>K </i>= 2Samples and Class: 76 normal; 105 tumorConfiguration: (ngr = 8, ngc = 4, nsr = 27, nsc = 28)http://genome-www5.stanford.edu/cgi-bin/publication/viewPublication.pl?pub_no=107</td></tr><tr><td>LYMPHOMA [47]</td><td>Microarrays: 81; Probes: 6,850; <i>K </i>= 3Samples and Class: 29 normal, 43 diffuse large B-cell lymphoma (DLBCL); 9 follicular lymphoma (FL)Configuration: (ngr = 4, ngc = 4, nsr = 24, nsc = 24); (ngr = 8, ngc = 4, nsr = 24, nsc = 24)http://genome-www5.stanford.edu/cgi-bin/publication/viewPublication.pl?pub_no=79</td></tr><tr><td>RENAL CELL CARCINOMA [48]</td><td>Microarrays: 38; Probes: 13,608; <i>K </i>= 4Samples and Class: 3 normal; 26 clear cell carcinoma (CCC); 5 granular cell carcinoma (GCC);4 papillary carcinoma (PC)Configuration: (ngr = 8, ngc = 4, nsr = 27, nsc = 28)http://genome-www5.stanford.edu/cgi-bin/publication/viewPublication.pl?pub_no=210</td></tr><tr><td>GASTRIC CARCINOMA [49]</td><td>Microarrays: 130; Probes: 15,541; <i>K </i>= 2Samples and Class : 28 normal; 102 tumorConfiguration: (ngr = 12, ngc = 4, nsr = 30, nsc = 32); (ngr = 12, ngc = 4, nsr = 29, nsc = 32); (ngr = 12, ngc = 4, nsr = 30, nsc = 30)http://genome-www5.stanford.edu/cgi-bin/publication/viewPublication.pl?pub_no=232</td></tr><tr><td>LUNG CANCER [50]</td><td>Microarrays: 60; Probes: 20,601; <i>K </i>= 5Samples and Class: 6 normal; 35 adenocarcinoma (AC); 11 squamous cell carcinoma (SCC); 4 large cell lung cancer (LCLC); 4 small cell lung cancer (SCLC)Configuration: (ngr = 8, ngc = 4, nsr = 27, nsc = 28)http://genome-www5.stanford.edu/cgi-bin/publication/viewPublication.pl?pub_no=100</td></tr></table>
16c12aabdf27a1ac35acbeddf70f9798a996e9b800e0317f8febc5f3f64cbd51.png	complex	<table><tr><td rowspan="2">Clinical characteristics</td><td colspan="3">LINE-1 methylation ratio by age and sex-adjusted</td></tr><tr><td>B</td><td>95% CI</td><td><i>P</i></td></tr><tr><td>HbA1c (%)</td><td>0.043</td><td>0.034 to 0.052</td><td>< 0.001</td></tr><tr><td>FBG (mmol/l)</td><td>0.063</td><td>0.048 to 0.077</td><td>< 0.001</td></tr><tr><td>TC (mmol/L)</td><td>−0.016</td><td>−0.024 to −0.009</td><td>< 0.001</td></tr><tr><td>TG (mmol/L)</td><td>0.001</td><td>−0.005 to 0.008</td><td>0.685</td></tr><tr><td>HDL-C (mmol/L)</td><td>−0.005</td><td>−0.008 to −0.003</td><td>< 0.001</td></tr><tr><td>LDL-C (mmol/L)</td><td>−0.019</td><td>−0.025 to −0.012</td><td>< 0.001</td></tr><tr><td>ApoA1 (g/l)</td><td>−0.002</td><td>−0.005 to 0.000</td><td>0.053</td></tr><tr><td>ApoB (g/l)</td><td>−0.004</td><td>−0.006 to −0.001</td><td>0.006</td></tr><tr><td>Hcy (μmol/l)</td><td>−0.251</td><td>−0.579 to 0.077</td><td>0.132</td></tr><tr><td>SBP (mmhg)</td><td>−0.245</td><td>−0.512 to 0.021</td><td>0.071</td></tr><tr><td>DBP (mmhg)</td><td>−0.018</td><td>−0.173 to 0.138</td><td>0.824</td></tr><tr><td>BMI</td><td>0.008</td><td>−0.039 to 0.056</td><td>0.732</td></tr></table>
58587cca8cff0ee88dfbfc942999f16c1f96aaac4ca1f62afb8c3dcd3e672d68.png	simple	<table><tr><td> </td><td>Total(<i>n</i> = 1889)</td><td>Male</td><td>Female</td><td><i>P</i></td></tr><tr><td>WC ≥90 cm in men and ≥80 cm in women, <i>n</i> (%)</td><td>278 (14.7)</td><td>85 (11.2)</td><td>193 (17.1)</td><td><0.001</td></tr><tr><td>SBP ≥130 mm Hg or DBP ≥85 mm Hg or hypertensive treatment, <i>n</i> (%)</td><td>1064 (56.3)</td><td>406 (53.4)</td><td>658 (58.3)</td><td><0.05</td></tr><tr><td>HDL-c <40 mg/dL in men and <50 mg/dL in women, <i>n</i> (%)</td><td>264 (14.0)</td><td>123 (16.2)</td><td>141 (12.5)</td><td><0.05</td></tr><tr><td>TG ≥150 mg/dL, <i>n</i> (%)</td><td>226 (12.0)</td><td>100 (13.2)</td><td>126 (11.2)</td><td>0.19</td></tr><tr><td>FPG ≥100 mg/dL or diabetes treatment, <i>n</i> (%)</td><td>432 (22.9)</td><td>202 (26.6)</td><td>230 (20.4)</td><td><0.05</td></tr></table>
577e9380158cf320b12bca7ccdbf50839bb44e4739ac3939970c3af484e35915.png	simple	<table><tr><td> </td><td>Ingenuity canonical pathways</td><td><i>p</i>-value</td><td>Ratio</td><td>Molecules</td></tr><tr><td>A</td><td>TREM1 signaling</td><td>2.71 × 10<sup>-11</sup></td><td>1.69 × 10<sup>-1</sup></td><td>IL8, CXCL3, ICAM1, CD40, GRB2, IL10, TLR8, CASP1, IL1B, FCGR2B, NFKB1, TNF</td></tr><tr><td> </td><td>Hepatic fibrosis/hepatic stellate cell activation</td><td>8.32 × 10<sup>-11</sup></td><td>1.10 × 10<sup>-1</sup></td><td>CXCL3, IL8, IL4R, CCR5, ICAM1, CD40, MYL6, IL10, IL6R, IL1B, IFNGR1, CCL5, NFKB1, TNF, CCR7, IL4</td></tr><tr><td> </td><td>IL-10 signaling</td><td>3.82 × 10<sup>-9</sup></td><td>1.41 × 10<sup>-1</sup></td><td>TRAF6, SOCS3, FOS, IL4R, CCR5, MAPK14, IL10, IL1B, FCGR2B, NFKB1, TNF</td></tr><tr><td> </td><td>IL-12 signaling and production in macrophages</td><td>6.87 × 10<sup>-9</sup></td><td>8.97 × 10<sup>-2</sup></td><td>IL10, MAF, IFNGR1, NFKB1, IRF1, TRAF6, FOS, MAPK14, CD40, ZNF668, NOS2, TNF, PRKD3, IL4</td></tr><tr><td> </td><td>IL-17A signaling in gastric cells</td><td>3.33 × 10<sup>-8</sup></td><td>2.80 × 10<sup>-1</sup></td><td>IL8, FOS, MAPK14, CCL20, CCL5, NFKB1, TNF</td></tr><tr><td>B</td><td>Role of cytokines in mediating communication between immune cells</td><td>8.88 × 10<sup>-7</sup></td><td>7.27 × 10<sup>-2</sup></td><td>IL8, IFNB1, IL13, IL4</td></tr><tr><td> </td><td>Communication between innate and adaptive immune cells</td><td>6.73 × 10<sup>-6</sup></td><td>3.67 × 10<sup>-2</sup></td><td>IL8, IFNB1, CCR7, IL4</td></tr><tr><td> </td><td>Airway inflammation in asthma</td><td>1.81 × 10<sup>-5</sup></td><td>3.33 × 10<sup>-1</sup></td><td>IL13, IL4</td></tr><tr><td> </td><td>Remodeling of epithelial adherens junctions</td><td>1.08 × 10<sup>-4</sup></td><td>4.41 × 10<sup>-2</sup></td><td>ACTR3, MAPRE1, CLIP1</td></tr><tr><td> </td><td>Prolactin signaling</td><td>1.5 × 10<sup>-4</sup></td><td>3.75 × 10<sup>-2</sup></td><td>SOCS3, FOS, IRF1</td></tr></table>
3b7f227d5dae335b6f40bcceb247634a9dedd073f6c968fb24e526260a237235.png	complex	<table><tr><td></td><td colspan="3">Univariable</td><td colspan="3">Multivariable</td></tr><tr><td></td><td>Odds ratio</td><td>Confidential interval</td><td><i>p</i> value</td><td>Odds ratio</td><td>Confidential interval</td><td><i>p</i> value</td></tr><tr><td>Age</td><td>0.98</td><td>0.95–1.03</td><td>0.63</td><td>1.02</td><td>0.96–1.10</td><td>0.49</td></tr><tr><td>Initial rhythm (VF and pulseless VT/asystole and PEA)</td><td>1.47</td><td>0.51–4.22</td><td>0.46</td><td>1.42</td><td>0.32–6.27</td><td>0.64</td></tr><tr><td>Location(out/in)</td><td>1.17</td><td>0.42–3.26</td><td>0.64</td><td>10.0</td><td>1.35–75.0</td><td>0.01</td></tr><tr><td>CPR duration</td><td>1.02</td><td>0.99–1.05</td><td>0.22</td><td>1.08</td><td>1.01–1.12</td><td>0.02</td></tr><tr><td>pH</td><td>25.2</td><td>1.24–509</td><td>0.03</td><td>247</td><td>4.16–15,000</td><td>< 0.01</td></tr><tr><td>Lactate clearance (high/low)</td><td>5.3</td><td>1.67–16.8</td><td>0.01</td><td>7.10</td><td>1.71–29.5</td><td>< 0.01</td></tr></table>
4dca5de86ee0bea11d0aaf2a2acb9bc2acdd1d2c3989da417a521037fb64b9eb.png	complex	<table><tr><td rowspan="2">Parameter</td><td colspan="2">Total</td><td colspan="2">With ≥ 2-year complete follow-up</td></tr><tr><td>Female</td><td>Male</td><td>Female</td><td>Male</td></tr><tr><td>Number of patients </td><td>802</td><td>526</td><td>463</td><td>313</td></tr><tr><td>Number of knees</td><td>1069</td><td>716</td><td>574</td><td>397</td></tr><tr><td>Proportion right knees</td><td>51.7%</td><td>49.4%</td><td>51.4%</td><td>49.4%</td></tr><tr><td>Patient age, mean (range) years</td><td>71.9 (39–95)</td><td>70.9 (44–96)</td><td>73.3 (50–94)</td><td>71.6 (48–95)</td></tr><tr><td>Body mass index mean (range) kg/m<sup>2</sup></td><td>33.2 (18–76)</td><td>32.3 (8–79)</td><td>32.6 (18–62)</td><td>32.0 (8–57)</td></tr><tr><td>Diagnosis</td><td> </td><td> </td><td> </td><td> </td></tr><tr><td> Osteoarthritis</td><td>97.5%</td><td>98.6%</td><td>97.4%</td><td>98.7%</td></tr><tr><td> Rheumatoid arthritis</td><td>1.6%</td><td>0.8%</td><td>1.9%</td><td>1.0%</td></tr><tr><td> Avascular necrosis</td><td>0.6%</td><td>0.3%</td><td>0.4%</td><td>0.3%</td></tr><tr><td> Osteonecrosis</td><td>0.1%</td><td>0.0%</td><td>0.2%</td><td>0.0%</td></tr><tr><td> Posttraumatic arthritis</td><td>0.1%</td><td>0.1%</td><td>0.2%</td><td>0.0%</td></tr><tr><td> Others</td><td>0.2%</td><td>0.1%</td><td>0.0%</td><td>0.0%</td></tr><tr><td>Length-of-stay, mean (range) days</td><td>2.5 (1–18)</td><td>2.2 (1–22)</td><td>2.4 (1–10)</td><td>2.1 (1–11)</td></tr><tr><td>Follow-up, mean (range) years</td><td>2.4 (0.7–7.2) </td><td>2.4 (0.8–6.9)</td><td>2.9 (2–7.2)</td><td>2.9 (2–6.9)</td></tr></table>
c1813d27d41782b9dd3ae7a0d246386744d4f636e4d97ffbd9d10381df922380.png	simple	<table><tr><td>Parameters</td><td>Negative control</td><td>Standardmisoprostol 100 <i>μ</i>g/kg</td><td>Test-ITDFME 125 mg/kg</td><td>Test-IITDFME250 mg/kg</td><td>Test-IIITDFME500 mg/kg</td></tr><tr><td>Catalase</td><td>2.89 ± 0.11 (0.27)</td><td>4.09 ± 0.18 (0.44)<sup>b</sup></td><td>3.86 ± 0.12 (0.49)<sup>a</sup></td><td>3.94 ± 0.20 (0.49)<sup>a</sup></td><td>4.23 ± 0.38 (0.94)<sup>b</sup></td></tr><tr><td>Malondialdehyde</td><td>7.11 ± 0.30 (0.74)</td><td>2.69 ± 0.23 (0.57)<sup>c</sup></td><td>5.64 ± 0.29 (0.73)<sup>b</sup></td><td>4.94 ± 0.16 (0.40)<sup>c</sup></td><td>3.58 ± 0.24 (0.60)<sup>c</sup></td></tr><tr><td>Mucin content</td><td>0.52 ± 0.06 (0.15)</td><td>1.07 ± 0.11 (0.27)<sup>b</sup></td><td>0.95 ± 0.15 (0.37)<sup>a</sup></td><td>1.15 ± 0.10 (0.24)<sup>b</sup></td><td>1.89 ± 0.11 (0.29)<sup>c</sup></td></tr><tr><td>Nonprotein sulphhydryl concentration</td><td>2.31 ± 0.18 (0.45)</td><td>4.55 ± 0.17 (0.42)<sup>c</sup></td><td>3.00 ± 0.19 (0.47)<sup>b</sup></td><td>3.07 ± 0.09 (0.24)<sup>b</sup></td><td>4.98 ± 0.00 (0.23)<sup>c</sup></td></tr><tr><td>Superoxide dismutase</td><td>2.75 ± 0.35 (0.86)</td><td>5.99 ± 0.31 (0.78)<sup>c</sup></td><td>2.44 ± 0.30 (0.74)<sup>ns</sup></td><td>4.05 ± 0.23 (0.57)<sup>a</sup></td><td>4.07 ± 0.24 (0.59)<sup>a</sup></td></tr><tr><td>Total protein content</td><td>342.5 ± 4.09 (10.03)</td><td>313.2 ± 3.22 (7.91)<sup>c</sup></td><td>321.7 ± 4.68 (11.47)<sup>b</sup></td><td>316.5 ± 5.50 (13.49)<sup>b</sup></td><td>251.7 ± 4.15 (10.17)<sup>c</sup></td></tr><tr><td>Ulcer index</td><td>10 ± 0.28 (0.70)</td><td>4.50 ± 0.42 (1.04)<sup>c</sup></td><td>7.08 ± 0.58 (1.42)<sup>c</sup></td><td>4.00 ± 0.36 (0.89)<sup>c</sup></td><td>1.50 ± 0.46 (1.14)<sup>c</sup></td></tr></table>
4ee3e2d4fca0f3b40c55c128f45b250ae81a3431cb8aaa17c406aec1d087b553.png	complex	<table><tr><td rowspan="2">Time points</td><td colspan="3">Bowel movement frequency, mean ± SD, episodes per wk</td><td colspan="3">Stool consistency, mean ± SD, BSFS grade</td></tr><tr><td>PEG</td><td>PEG + PM</td><td><i>P</i></td><td>PEG</td><td>PEG + PM</td><td><i>P</i></td></tr><tr><td>Enrollment</td><td>2.5 ± 1.1</td><td>2.3 ± 0.7</td><td>0.344</td><td>2.6 ± 0.6</td><td>2.5 ± 0.7</td><td>0.395</td></tr><tr><td>2-week follow-up visit</td><td>5.9 ± 1.3</td><td>5.4 ± 1.4</td><td>0.168</td><td>4.2 ± 0.5</td><td>3.9 ± 1.0</td><td>0.271</td></tr><tr><td>4-week follow-up visit</td><td>6.3 ± 0.9</td><td>6.0 ± 1.2</td><td>0.659</td><td>4.4 ± 0.5</td><td>4.1 ± 0.6</td><td>0.267</td></tr><tr><td>8-week follow-up visit</td><td>6.3 ± 0.9</td><td>6.3 ± 1.0</td><td>0.924</td><td>4.2 ± 0.5</td><td>4.2 ± 0.5</td><td>0.857</td></tr></table>
9a57dfa7af9291d491ed2f26b15e80c7a382dc3f96c9ad42450431f307d3228c.png	complex	<table><tr><td rowspan="2">Variants</td><td rowspan="2">AA change</td><td rowspan="2">Novel</td><td rowspan="2">Exon</td><td colspan="2">Sift Prediction</td><td colspan="2">Polyphen Prediction</td><td colspan="3">MAF (%)</td></tr><tr><td>Score</td><td>Prediction</td><td>Score</td><td>Prediction</td><td>Control</td><td>PS</td><td>PSE</td></tr><tr><td>+21059 C/T</td><td>333A > T</td><td>Yes</td><td>5</td><td>0.28</td><td>Tolerated</td><td>0</td><td>Benign</td><td>0</td><td>0.5</td><td>0</td></tr><tr><td>+21029 C/G</td><td>323A > P</td><td>Yes</td><td>5</td><td>0.08</td><td>Tolerated</td><td>0.476</td><td>Possibly damaging</td><td>0.5</td><td>0</td><td>0</td></tr><tr><td>rs2296651</td><td>267S > F</td><td>No</td><td>4</td><td>0.31</td><td>Tolerated</td><td>0.88</td><td>Probably damaging</td><td>0.9</td><td>0.9</td><td>2.3</td></tr><tr><td>+18885 A/G</td><td>256 M > T</td><td>Yes</td><td>4</td><td>0</td><td>Damaging</td><td>0.839</td><td>Possibly damaging</td><td>0</td><td>0</td><td>0.5</td></tr><tr><td>+18131 A/G</td><td>222 L > S</td><td>Yes</td><td>3</td><td>0</td><td>Damaging</td><td>0.637</td><td>Possibly damaging</td><td>0</td><td>0</td><td>0.5</td></tr><tr><td>rs202213974</td><td>200 V > M</td><td>No</td><td>3</td><td>0</td><td>Damaging</td><td>0.819</td><td>Possibly damaging</td><td>0</td><td>0</td><td>0.5</td></tr><tr><td>+11121 G/C</td><td>131 L > V</td><td>Yes</td><td>2</td><td>0.23</td><td>Tolerated</td><td>0.484</td><td>Possibly damaging</td><td>0.5</td><td>0</td><td>0</td></tr><tr><td>rs148467625</td><td>88I > T</td><td>No</td><td>1</td><td>0.57</td><td>Tolerated</td><td>0.072</td><td>Benign</td><td>0.5</td><td>0.5</td><td>0</td></tr></table>
a4186abaa92333bb2aceb1396dad498ef0e219a1320d5704984413bc2e77e5cd.png	simple	<table><tr><td>Original value</td><td>HNR-I</td><td>HNR-II</td><td>HNR-III</td><td>HNR-IV</td><td>HNR-V</td><td>HNR-VI</td><td>Total </td></tr><tr><td>1-10</td><td>O/13</td><td>15/30</td><td>20/27</td><td>0/1</td><td>11/11</td><td>15/20</td><td><underline>61/102</underline>*<sup>#</sup></td></tr><tr><td>10-20</td><td>O/21</td><td>1/41</td><td>5/21</td><td>0/21</td><td>0/3</td><td>0/0</td><td>6/107<sup>§</sup></td></tr><tr><td>≥20</td><td>0/16</td><td>0/16</td><td>0/21</td><td>0/16</td><td>0/23</td><td>0/26</td><td>0/118</td></tr><tr><td>Total</td><td>0/50</td><td>16/87</td><td>25/69</td><td>0/38</td><td>11/37</td><td>15/46</td><td>67/327</td></tr></table>
c8e6a81f63d606fead334323f1e0618f65ea455f8eb7fd8531cb62638e5abdf7.png	complex	<table><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td colspan="2">ICGA</td><td>FA</td><td></td></tr><tr><td>No.</td><td>Age</td><td>Sex</td><td>R/L</td><td>Cell/Flare</td><td>SRD</td><td>Optic disc hyperemia</td><td>Fuzzy choroidal vessels</td><td>Hypofluorescent dark dots</td><td>Pinpoints Hyperfluorescence</td><td>Pleocytosis</td></tr><tr><td>1</td><td>34</td><td>F</td><td>L</td><td>+</td><td>−</td><td>−</td><td>+</td><td>+</td><td>−</td><td>+</td></tr><tr><td rowspan="2">2</td><td rowspan="2">56</td><td rowspan="2">F</td><td>R</td><td>−</td><td>+</td><td>+</td><td>+</td><td>+</td><td>+</td><td rowspan="2">+</td></tr><tr><td>L</td><td>−</td><td>+</td><td>+</td><td>+</td><td>+</td><td>+</td></tr><tr><td rowspan="2">3</td><td rowspan="2">31</td><td rowspan="2">F</td><td>R</td><td>−</td><td>+</td><td>+</td><td>+</td><td>+</td><td>+</td><td rowspan="2">+</td></tr><tr><td>L</td><td>+</td><td>+</td><td>+</td><td>+</td><td>+</td><td>+</td></tr><tr><td>4</td><td>43</td><td>F</td><td>R</td><td>+</td><td>+</td><td>+</td><td>+</td><td>+</td><td>+</td><td>+</td></tr><tr><td rowspan="2">5</td><td rowspan="2">57</td><td rowspan="2">F</td><td>R</td><td>+</td><td>+</td><td>+</td><td>+</td><td>+</td><td>+</td><td rowspan="2">+</td></tr><tr><td>L</td><td>+</td><td>−</td><td>+</td><td>+</td><td>+</td><td>−</td></tr><tr><td>6</td><td>24</td><td>M</td><td>R</td><td>−</td><td>+</td><td>+</td><td>+</td><td>+</td><td>+</td><td>+</td></tr><tr><td>7</td><td>44</td><td>M</td><td>R</td><td>−</td><td>−</td><td>+</td><td>+</td><td>+</td><td>−</td><td>+</td></tr><tr><td>8</td><td>46</td><td>F</td><td>R</td><td>+</td><td>−</td><td>+</td><td>+</td><td>+</td><td>−</td><td>−</td></tr><tr><td rowspan="2">9</td><td rowspan="2">64</td><td rowspan="2">M</td><td>R</td><td>+</td><td>+</td><td>+</td><td>+</td><td>+</td><td>+</td><td rowspan="2">+</td></tr><tr><td>L</td><td>+</td><td>+</td><td>+</td><td>+</td><td>+</td><td>+</td></tr><tr><td rowspan="2">10</td><td rowspan="2">15</td><td rowspan="2">M</td><td>R</td><td>+</td><td>+</td><td>+</td><td>+</td><td>+</td><td>+</td><td rowspan="2">+</td></tr><tr><td>L</td><td>+</td><td>−</td><td>+</td><td>unknown</td><td>+</td><td>−</td></tr></table>
383f41dc38087c95b12dd75187a6cd0179d23067ae07e2fcdb9ad8e98566954e.png	complex	<table><tr><td>Supernatant</td><td>Colorimetric</td><td>HPLC</td><td>Difference</td></tr><tr><td>1</td><td>3.8</td><td>3.3</td><td>0.5</td></tr><tr><td>2</td><td>13</td><td>12.7</td><td>0.3</td></tr><tr><td>3</td><td>12.3</td><td>11.7</td><td>0.6</td></tr><tr><td>4</td><td>2.2</td><td>3</td><td>−0.8</td></tr><tr><td>5</td><td>12.7</td><td>13.7</td><td>−1.0</td></tr><tr><td>6</td><td>10.6</td><td>11.2</td><td>−0.6</td></tr><tr><td>7</td><td>0.9</td><td>1.1</td><td>−0.2</td></tr><tr><td>8</td><td>14.8</td><td>13.9</td><td>0.9</td></tr><tr><td>9</td><td>3.9</td><td>3.9</td><td>0.0</td></tr><tr><td colspan="4">  </td></tr><tr><td colspan="3"><i>d</i> (average on difference)</td><td>0.03</td></tr><tr><td colspan="3"><i>s</i><sub><i>d</i></sub> (standard deviation of difference)</td><td>0.7</td></tr></table>
ec4ac7fd821387fe794b5d6cc9b3849f1388461daf26d3e6ec9d89c28f7c9edc.png	simple	<table><tr><td>Item NO.</td><td>PF</td><td>EF</td><td>SF</td><td>SchF</td></tr><tr><td>PF</td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>QOL1</td><td>.42</td><td>.21</td><td>.30<sub>$</sub></td><td>.26</td></tr><tr><td>QOL2</td><td>.44</td><td>.18</td><td>.33<sub>$</sub></td><td>.28</td></tr><tr><td>QOL3</td><td>.53</td><td>.14</td><td>.26</td><td>.29</td></tr><tr><td>QOL4</td><td>.39</td><td>.13</td><td>.31<sub>$</sub></td><td>.22</td></tr><tr><td>QOL5</td><td><underline>.33</underline></td><td>.13</td><td>.21<sub>$</sub></td><td>.07</td></tr><tr><td>QOL6</td><td>.48</td><td>.21</td><td>.26</td><td>.21</td></tr><tr><td>QOL7</td><td>.45</td><td>.25</td><td>.19</td><td>.21</td></tr><tr><td>QOL8</td><td>.43</td><td>.32<sub>$</sub></td><td>.23</td><td>.19</td></tr><tr><td>EF</td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>QOL9</td><td>.16</td><td><underline>.37</underline></td><td>.17</td><td>.25<sub>$</sub></td></tr><tr><td>QOL10</td><td>.25</td><td>.51</td><td>.25</td><td>.19</td></tr><tr><td>QOL11</td><td>.16</td><td><underline>.37</underline></td><td>.25<sub>$</sub></td><td>.16</td></tr><tr><td>QOL12</td><td>.25<sub>$</sub></td><td><underline>.27</underline></td><td>.39*<sub>$</sub></td><td>.29<sub>$</sub></td></tr><tr><td>QOL13</td><td>.22<sub>$</sub></td><td><underline>.20</underline></td><td>.34<sub>$</sub></td><td>.32<sub>$</sub></td></tr><tr><td>SF</td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>QOL14</td><td>.33<sub>$</sub></td><td>.32<sub>$</sub></td><td>.<underline>27</underline></td><td>.29*<sub>$</sub></td></tr><tr><td>QOL15</td><td>.31<sub>$</sub></td><td>.28</td><td>.45</td><td>.23</td></tr><tr><td>QOL16</td><td>.25</td><td>.27</td><td>.46</td><td>.30</td></tr><tr><td>QOL17</td><td>.23</td><td>.31</td><td>.47</td><td>.47<sub>$</sub></td></tr><tr><td>QOL18</td><td>.22</td><td>.22</td><td>.39</td><td>.37<sub>$</sub></td></tr><tr><td>SchF</td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>QOL19</td><td>.27</td><td>.33</td><td>.36</td><td>.52</td></tr><tr><td>QOL20</td><td>.26</td><td>.41</td><td>.39</td><td>.55</td></tr><tr><td>QOL21</td><td>.24</td><td>.32</td><td>.38</td><td>.53</td></tr><tr><td>QOL22</td><td>.30</td><td>.14</td><td>.33</td><td>.56</td></tr><tr><td>QOL23</td><td>.30</td><td>.19</td><td>.36</td><td>.57</td></tr></table>
ac4254f575574f6ff2861603281e30c27c00b44fe78d979944093c923b37abd7.png	complex	<table><tr><td>Potential operon (r value)</td><td>Gene ID</td><td>Putative or predicted function</td><td>Reference (s)</td></tr><tr><td colspan="4">Iron uptake or heme synthesis</td></tr><tr><td> <i>yfeABCD </i>operon* (r > 0.91)</td><td>YPO2439-2442</td><td>Transport/binding chelated iron</td><td><i>yfeABCD </i>[54]</td></tr><tr><td> <i>hmuRSTUV </i>operon (r > 0.90)</td><td>YPO0279-0283</td><td>Transport/binding hemin</td><td><i>hmuRSTUV </i>[55]</td></tr><tr><td> <i>ysuJIHG* </i>(r > 0.95)</td><td>YPO1529-1532</td><td>Iron uptake</td><td>-</td></tr><tr><td> <i>sufABCDS* </i>(r > 0.90)</td><td>YPO2400-2404</td><td>Iron-regulated Fe-S cluster assembly?</td><td>-</td></tr><tr><td> YPO1854-1856* (r > 0.97)</td><td>YPO1854-1856</td><td>Iron uptake or heme synthesis?</td><td>-</td></tr><tr><td colspan="4">Sulfur metabolism</td></tr><tr><td> <i>tauABCD </i>operon (r > 0.90)</td><td>YPO0182-0185</td><td>Transport/binding taurine</td><td><i>tauABCD </i>[56]</td></tr><tr><td> <i>ssuEADCB </i>operon (r > 0.97)</td><td>YPO3623-3627</td><td>Sulphur metabolism</td><td><i>ssu </i>operon [57]</td></tr><tr><td> <i>cys </i>operon (r > 0.92)</td><td>YPO3010-3015</td><td>Cysteine synthesis</td><td>-</td></tr><tr><td> YPO1317-1319 (r > 0.97)</td><td>YPO1317-1319</td><td>Sulfur metabolism?</td><td>-</td></tr><tr><td> YPO4109-4111 (r > 0.90)</td><td>YPO4109-4111</td><td>Sulfur metabolism?</td><td>-</td></tr><tr><td colspan="4">Urea uptake and urease activation</td></tr><tr><td> <i>ure </i>operon* (r > 0.96)</td><td>YPO2665-2672</td><td>Pathogenicity</td><td><i>ure </i>[58, 59]</td></tr><tr><td colspan="4">Stress response and adaptation</td></tr><tr><td> <i>dnaKJ </i>operon (r = 0.97)</td><td>YPO0468-0469</td><td>Chaperones, chaperonins, heat shock</td><td><i>dnaKJ </i>[60, 61]</td></tr><tr><td> <i>hslUV </i>operon (r = 0.97)</td><td>YPO0105-0106</td><td>Adaptions and atypical conditions</td><td><i>hslUV </i>[62]</td></tr><tr><td> <i>katY-cybCB </i>operon* (r > 0.90)</td><td>YPO3319-3321</td><td>Detoxification and electron transport</td><td>-</td></tr><tr><td> <i>psp </i>operon (r > 0.90)</td><td>YPO2349-2351</td><td>Adaptions and atypical conditions</td><td><i>psp </i>operon [63]</td></tr><tr><td colspan="4">Ribosome constituents</td></tr><tr><td> <i>rps-rpm-rpl </i>operon (r > 0.90)</td><td>YPO0209-0235</td><td>Ribosomal protein synthesis and modification</td><td><i>rps-rpm-rpl </i>operon [64]</td></tr><tr><td colspan="4">Energy metabolism</td></tr><tr><td> <i>sdh-suc </i>operon* (r > 0.92)</td><td>YPO1109-1116</td><td>Tricarboxylic acid cycle</td><td><i>sdhCDAB </i>[65]</td></tr><tr><td> <i>cyo </i>operon (r > 0.94)</td><td>YPO3164-3168</td><td>Aerobic respiration</td><td><i>cyoABCDE </i>[55]</td></tr><tr><td> <i>nap </i>operon (r > 0.94)</td><td>YPO3036-3040</td><td>Electron transport</td><td><i>nap </i>operon [66]</td></tr><tr><td> <i>atp </i>operon (r > 0.93)</td><td>YPO4120-4128</td><td>ATP-proton motive force</td><td><i>atpIBEFHAGDC </i>[67]</td></tr><tr><td> <i>ace </i>operon* (r > 0.90)</td><td>YPO3724-3726</td><td>Glyoxylate bypass</td><td><i>aceBAK </i>[68]</td></tr><tr><td> <i>nuo </i>operon* (r > 0.92)</td><td>YPO2543-2555</td><td>Aerobic respiration</td><td><i>nuo </i>operon [69]</td></tr><tr><td colspan="4">Degradation and transport/binding of amino acids</td></tr><tr><td> <i>pro </i>operon* (r > 0.92)</td><td>YPO2645-2647</td><td>Transport/binding amino acids and amines</td><td><i>proVWX </i>[70]</td></tr><tr><td> <i>ast </i>operon (r > 0.90)</td><td>YPO1962-1966</td><td>Degradation of amino acids</td><td><i>astCADBE </i>[71]</td></tr><tr><td> <i>gln </i>operon* (r > 0.91)</td><td>YPO2512-2514</td><td>Transport/binding amino acids and amines</td><td><i>glnHPQ </i>[72]</td></tr><tr><td colspan="4">others</td></tr><tr><td> YPO1994-1996* (r > 0.98)</td><td>YPO1994-1996</td><td>Unknown</td><td>-</td></tr><tr><td> YPO0881-0884 (r = 0.99)</td><td>YPO0881-0884</td><td>Chemotaxis and mobility?</td><td>-</td></tr><tr><td> YPO1087-1088 (r = 0.99)</td><td>YPO1087-1088</td><td>Phage-related functions and prophage</td><td>-</td></tr><tr><td> YPO0623-0628* (r > 0.94)</td><td>YPO0623-0628</td><td>Unknown</td><td>-</td></tr><tr><td> <i>mur </i>operon (r > 0.95)</td><td>YPO0550-0553</td><td>Murein sacculus and peptidoglycan</td><td>-</td></tr><tr><td> <i>idn </i>operon (r = 0.96)</td><td>YPO2539-2540</td><td>Degradation of carbon compounds</td><td>-</td></tr><tr><td> <i>fad </i>operon* (r = 0.95)</td><td>YPO3766-3767</td><td>Degradation of small molecule</td><td>-</td></tr><tr><td> <i>glg </i>operon (r > 0.90)</td><td>YPO3938-3942</td><td>Synthesis and modification of cytoplasmic polysaccharides</td><td><i>glg </i>operon [73]</td></tr><tr><td> YPO3838-3839 (r = 0.92)</td><td>YPO3838-3839</td><td>Unknown</td><td>-</td></tr><tr><td> YPO0408-0409* (r = 0.97)</td><td>YPO0408-0409</td><td>Unknown</td><td>-</td></tr><tr><td> YPO1516-1517 (r = 0.90)</td><td>YPO1516-1517</td><td>Unknown</td><td>-</td></tr><tr><td> YPCD1.15c-1.17c (r > 0.98)</td><td>YPCD1.15c-1.17c</td><td>Unknown</td><td>-</td></tr><tr><td> <i>yscGHIJK </i>operon* (>0.90)</td><td>YPCD1.55-1.57</td><td>T3SS constituents</td><td>-</td></tr><tr><td> YPPCP1.08c-1.09c (r = 0.97)</td><td>YPPCP1.08c-1.09c</td><td>Unknown</td><td>-</td></tr></table>
25f1b3fe4172c4ba1544c49f5778635bbe20de20b8a355b96ee20c57a4e59167.png	complex	<table><tr><td rowspan="2">Variable</td><td colspan="3">Male</td><td colspan="3">Female</td><td colspan="3">Overall</td></tr><tr><td>% active</td><td>95% CI</td><td><i>p</i> value</td><td>% active</td><td>95% CI</td><td><i>p</i> value</td><td>% active</td><td>95% CI</td><td><i>p</i> value</td></tr><tr><td colspan="10">Age (years)</td></tr><tr><td> 18–20</td><td>23.1</td><td>16.3–31.2</td><td rowspan="2">.24<sup>a</sup></td><td>5.5</td><td>2.2–10.9</td><td rowspan="2">.65<sup>a</sup></td><td>14.5</td><td>10.5–19.4</td><td rowspan="2">.11<sup>a</sup></td></tr><tr><td> 21–24</td><td>29.5</td><td>22.5–36.3</td><td>6.8</td><td>3.2–12.5</td><td>19.6</td><td>15.3–24.5</td></tr><tr><td colspan="10">Monthly family income (BDT)*</td></tr><tr><td> ≤20,000</td><td>25.0</td><td>16.4–35.4</td><td rowspan="4">.33<sup>a</sup></td><td>3.7</td><td>0.1–1.9</td><td rowspan="4">.99<sup>b</sup></td><td>20.0</td><td>13.1–28.5</td><td rowspan="4">.20<sup>a</sup></td></tr><tr><td> 20,001–40,000</td><td>33.3</td><td>23.9–43.9</td><td>5.8</td><td>1.6–14.2</td><td>21.6</td><td>15.5–28.7</td></tr><tr><td> 40,001–70,000</td><td>21.4</td><td>13.2–31.7</td><td>6.8</td><td>2.5–14.3</td><td>14.0</td><td>9.1–20.0</td></tr><tr><td> > 70,000</td><td>26.7</td><td>14.6–41.9</td><td>6.9</td><td>2.3–15.5</td><td>14.5</td><td>8.7–22.2</td></tr></table>
bc95c74aa0972f623bffac32339f2792315260b0d652956aba95389371028aae.png	complex	<table><tr><td rowspan="3">Age Group</td><td rowspan="3"></td><td colspan="4">Boys</td><td colspan="4">Girls</td></tr><tr><td colspan="4">WC/Ht percentile</td><td colspan="4">WC/Ht percentile</td></tr><tr><td colspan="2">< 97th</td><td colspan="2">97-100th</td><td colspan="2">< 97th</td><td colspan="2">97-100th</td></tr><tr><td rowspan="7">6-9 yr</td><td>n</td><td colspan="2">40</td><td colspan="2">154</td><td colspan="2">14</td><td colspan="2">142</td></tr><tr><td>Systolic BP < 130 mmHg</td><td>2/40</td><td>(5.0)</td><td>10/154</td><td>(6.5)</td><td>0/1</td><td>(0.0)</td><td>9/142</td><td>(6.3)</td></tr><tr><td>Dyastolic BP < 85 mmHg</td><td>2/40</td><td>(5.0)</td><td>8/154</td><td>(5.2)</td><td>1/14</td><td>(7.1)</td><td>11/142</td><td>(7.8)</td></tr><tr><td>BS < 5.6 mM</td><td>7/40</td><td>(17.5)</td><td>31/154</td><td>(20.1)</td><td>0/14</td><td>(0.0)</td><td>17/142</td><td>(12.0)</td></tr><tr><td>TG < 1.7 mM</td><td>0/40</td><td>(0.0)</td><td>10/154</td><td>(6.5)</td><td>0/14</td><td>(0.0)</td><td>5/142</td><td>(3.5)</td></tr><tr><td>HDL-C <1.03 mM</td><td>0/40</td><td>(0.0)</td><td>4/154</td><td>(2.6)</td><td>0/14</td><td>(0.0)</td><td>5/142</td><td>(3.5)</td></tr><tr><td>Two or more metabolic risk factors</td><td>0/40</td><td>(0.0)</td><td>7/154</td><td>(4.6)</td><td>0/14</td><td>(0.0)</td><td>2/142</td><td>(1.4)</td></tr><tr><td rowspan="7">10-12 yr</td><td>n</td><td colspan="2">78</td><td colspan="2">83</td><td colspan="2">38</td><td colspan="2">78</td></tr><tr><td>Systolic BP < 130 mmHg</td><td>11/78</td><td>(14.1)</td><td>15/83</td><td>(18.1)</td><td>2/15</td><td>(13.3)</td><td>10/59</td><td>(17.0)</td></tr><tr><td>Dyastolic BP < 85 mmHg</td><td>6/78</td><td>(7.7)</td><td>14/83</td><td>(16.9)</td><td>0/15</td><td>(0.0)</td><td>5/59</td><td>(8.5)</td></tr><tr><td>BS < 5.6 mM</td><td>17/78</td><td>(21.8)</td><td>20/83</td><td>(24.1)</td><td>4/15</td><td>(26.7)</td><td>11/59</td><td>(18.6)</td></tr><tr><td>TG < 1.7 mM</td><td>3/78</td><td>(3.9)</td><td>12/83</td><td>(14.5)</td><td>2/15</td><td>(13.3)</td><td>3/59</td><td>(5.1)</td></tr><tr><td>HDL-C <1.03 mM</td><td>0/78</td><td>(0.0)</td><td>6/83</td><td>(7.2)</td><td>1/15</td><td>(6.7)</td><td>0/59</td><td>(0.0)</td></tr><tr><td>Two or more metabolic risk factors</td><td>4/78</td><td>(5.1)</td><td>12/83</td><td>(14.5)</td><td>2/15</td><td>(13.3)</td><td>1/59</td><td>(1.7)</td></tr></table>
d064b8ebac6090fe4a2199e6f52b23079cc781ef277f2c55c2b9e8ad8a51b771.png	simple	<table><tr><td> </td><td>Actual positive</td><td>Actual negative</td></tr><tr><td>Predicted positive</td><td>TP</td><td>FP</td></tr><tr><td>Predicted negative</td><td>FN</td><td>TN</td></tr></table>
3a590148a950f60161672739f46a2519ded17cbfa435ba5a163a529d685acf00.png	simple	<table><tr><td></td><td>NS</td><td>HA</td><td>RD</td><td>P</td><td></td></tr><tr><td>NS</td><td>–</td><td>−0.431<sup>*</sup></td><td>0.207<sup></sup></td><td>−0.128</td><td></td></tr><tr><td>HA</td><td>−0.431<sup>*</sup></td><td>–</td><td>0.009</td><td>−0.165</td><td></td></tr><tr><td>RD</td><td>0.207<sup></sup></td><td>0.009</td><td>–</td><td>−0.088</td><td></td></tr><tr><td>P</td><td>−0.128</td><td>−0.165</td><td>−0.088</td><td>–</td><td></td></tr><tr><td></td><td>NS</td><td>NS1</td><td>NS2</td><td>NS3</td><td>NS4</td></tr><tr><td>NS</td><td>–</td><td>0.551<sup></sup></td><td>0.652<sup></sup></td><td>0.715<sup></sup></td><td>0.640<sup></sup></td></tr><tr><td>NS1</td><td>0.551<sup></sup></td><td>–</td><td>−0.006</td><td>0.335<sup></sup></td><td>0.151</td></tr><tr><td>NS2</td><td>0.652<sup></sup></td><td>−0.006</td><td>–</td><td>0.294<sup></sup></td><td>0.357<sup></sup></td></tr><tr><td>NS3</td><td>0.715<sup></sup></td><td>0.335<sup></sup></td><td>0.294<sup></sup></td><td>–</td><td>0.239<sup></sup></td></tr><tr><td>NS4</td><td>0.640<sup></sup></td><td>0.151</td><td>0.357<sup></sup></td><td>0.239<sup></sup></td><td>–</td></tr><tr><td></td><td>HA</td><td>HA1</td><td>HA2</td><td>HA3</td><td>HA4</td></tr><tr><td>HA</td><td>–</td><td>0.869<sup></sup></td><td>0.799<sup></sup></td><td>0.826<sup></sup></td><td>0.750<sup></sup></td></tr><tr><td>HA1</td><td>0.869<sup></sup></td><td>–</td><td>0.712<sup></sup></td><td>0.658<sup></sup></td><td>0.544<sup></sup></td></tr><tr><td>HA2</td><td>0.799<sup></sup></td><td>0.712<sup></sup></td><td>–</td><td>0.583<sup></sup></td><td>0.442<sup></sup></td></tr><tr><td>HA3</td><td>0.826<sup></sup></td><td>0.658<sup></sup></td><td>0.583<sup></sup></td><td>–</td><td>0.457<sup></sup></td></tr><tr><td>HA4</td><td>0.750<sup>*</sup></td><td>0.544<sup></sup></td><td>0.442<sup></sup></td><td>0.457<sup></sup></td><td>–</td></tr><tr><td></td><td>RD</td><td>RD1</td><td>RD2</td><td>RD3</td><td></td></tr><tr><td>RD</td><td>–</td><td>0.672<sup></sup></td><td>0.804<sup></sup></td><td>0.466<sup></sup></td><td></td></tr><tr><td>RD1</td><td>0.672<sup></sup></td><td>–</td><td>0.253<sup></sup></td><td>0.070</td><td></td></tr><tr><td>RD2</td><td>0.804<sup></sup></td><td>0.243<sup></sup></td><td>–</td><td>0.220<sup></sup></td><td></td></tr><tr><td>RD3</td><td>0.466<sup></sup></td><td>0.070</td><td>0.220<sup></sup></td><td>–</td><td></td></tr></table>
6585f957735f4590cbf0920cc688245f7498e630d9adab52952e343cf149b873.png	simple	<table><tr><td>Clinical source</td><td>Total strains</td><td>ZOT positivity</td><td>Exotoxin 9 positivity</td><td>GSI</td><td>GSII</td></tr><tr><td>CD</td><td>29</td><td>72.41</td><td>72.41</td><td>10.34</td><td>89.66</td></tr><tr><td>Gastroenteritis</td><td>31</td><td>70.97</td><td>51.61</td><td>35.48</td><td>64.52</td></tr><tr><td>Lymphocytic colitis</td><td>1</td><td>100</td><td>100</td><td>0</td><td>100</td></tr><tr><td>Collagenous colitis</td><td>3</td><td>33.33</td><td>100</td><td>33.33</td><td>66.67</td></tr><tr><td>Bloody diarrhoea</td><td>8</td><td>100</td><td>37.5</td><td>50</td><td>50</td></tr><tr><td>Periodontal disease</td><td>1</td><td>100</td><td>100</td><td>100</td><td>0</td></tr><tr><td>Healthy</td><td>11</td><td>72.73</td><td>63.64</td><td>27.27</td><td>72.73</td></tr><tr><td>UC</td><td>4</td><td>25</td><td>50</td><td>50</td><td>50</td></tr><tr><td>All</td><td>88</td><td>71.59</td><td>60.22</td><td>28.41</td><td>71.59</td></tr></table>
f4b16fa330f67deeb9b342bc6b9acc6dfb8dd143b86a64803ee32f81557adee8.png	simple	<table><tr><td>Anterior segment pathology</td><td>Number of eyes</td></tr><tr><td>Cornea diseases</td><td></td></tr><tr><td> Mucopolysaccharidosis</td><td>4</td></tr><tr><td> Keratoconus</td><td>3</td></tr><tr><td>Anterior segment congenital condition</td><td></td></tr><tr><td> Mesoectodermal dysgenesis</td><td>2</td></tr><tr><td> Sclerocornea</td><td>1</td></tr><tr><td> Congenital glaucoma</td><td>2</td></tr><tr><td> Microphthalmia</td><td>3</td></tr><tr><td> Keratoglobus</td><td>1</td></tr><tr><td>Ocular trauma</td><td></td></tr><tr><td> Self-sealing corneal penetrating injury</td><td>1</td></tr><tr><td>Anterior segment surgery</td><td></td></tr><tr><td> Cornea transplant and glaucoma drainage tube</td><td>1</td></tr><tr><td> Glaucoma drainage tube</td><td>1</td></tr><tr><td>Iridocorneal angle abnormalities</td><td></td></tr><tr><td> Anterior synechiae post-uveitis</td><td>1</td></tr><tr><td> Neovascular glaucoma</td><td>2</td></tr><tr><td> Synechia associated to ciliary body lesion</td><td>1</td></tr><tr><td>Intermediate Uveitis</td><td>2</td></tr><tr><td>Ocular surface lesions</td><td></td></tr><tr><td> Corneoscleral dermoid</td><td>1</td></tr></table>
9ae441ea559c6bd739e66f4bbf28ab33b8864d642ad81849eab472617bdce229.png	complex	<table><tr><td> </td><td colspan="3">Discussed with an HIV nurse practitioner</td><td colspan="3">Discussed with an HIV care medical doctor</td><td colspan="3">Discussed at the HIV care visit</td></tr><tr><td> </td><td>Never</td><td>Sometimes</td><td>Regularly</td><td>Never</td><td>Sometimes</td><td>Regularly</td><td>Never</td><td>Sometimes</td><td>Regularly</td></tr><tr><td>Topics that patients wanted to discuss</td><td>% (n)</td><td>% (n)</td><td>% (n)</td><td>% (n)</td><td>% (n)</td><td>% (n)</td><td>% (n)</td><td>% (n)</td><td>% (n)</td></tr><tr><td>STI-related symptoms</td><td>20 (12)</td><td>52 (30)</td><td>28 (16)</td><td>25 (15)</td><td>61 (36)</td><td>14 (8)</td><td>18 (11)</td><td>55 (33)</td><td>27 (16)</td></tr><tr><td>Information on STIs</td><td>24 (13)</td><td>48 (26)</td><td>28 (15)</td><td>23 (12)</td><td>57 (30)</td><td>21 (11)</td><td>13 (7)</td><td>52 (28)</td><td>35 (19)</td></tr><tr><td>Sexual problems</td><td>17 (8)</td><td>58 (28)</td><td>25 (12)</td><td>37 (17)</td><td>50 (23)</td><td>13 (6)</td><td>13 (6)</td><td>57 (27)</td><td>30 (13)</td></tr><tr><td>Safe sex information</td><td>14 (6)</td><td>60 (25)</td><td>26 (11)</td><td>20 (8)</td><td>59 (24)</td><td>22 (9)</td><td>14 (6)</td><td>52 (22)</td><td>34 (14)</td></tr><tr><td>Relationship and sex</td><td>11 (4)</td><td>67 (24)</td><td>22 (8)</td><td>23 (8)</td><td>60 (21)</td><td>17 (6)</td><td>11 (4)</td><td>61 (22)</td><td>28 (10)</td></tr><tr><td>Negative sexual experiences</td><td>25 (5)</td><td>60 (12)</td><td>15 (3)</td><td>58 (11)</td><td>37 (7)</td><td>5 (1)</td><td>25 (5)</td><td>60 (12)</td><td>15 (3)</td></tr><tr><td>Contraception</td><td>18 (3)</td><td>47 (8)</td><td>35 (6)</td><td>13 (2)</td><td>69 (11)</td><td>19 (3)</td><td>6 (1)</td><td>59 (10)</td><td>35 (6)</td></tr><tr><td>Pregnancy</td><td>11 (1)</td><td>71 (5)</td><td>14 (1)</td><td>0</td><td>100 (8)</td><td>0</td><td>0</td><td>88 (7)</td><td>12 (1)</td></tr></table>
8cbb3b2a292bbb4a10a21bf73e3eb12ca21117ee4ee868ddc3b37d08cffbc507.png	simple	<table><tr><td>Age</td><td>Discharge type</td><td>Single duct?</td><td>Initial surgery</td><td>Initial histology</td><td>Final histology</td><td>Treatment</td></tr><tr><td>32</td><td>Fresh blood</td><td>Yes</td><td>Micro</td><td>DCIS</td><td>Intermediate grade DCIS</td><td>Mx + ANS + recon</td></tr><tr><td>43</td><td>Fresh blood</td><td>No</td><td>TDE</td><td>DCIS</td><td>Extensive intermediate grade DCIS</td><td>Mx + ANS + recon</td></tr><tr><td>51</td><td>Fresh blood/serous</td><td>Yes</td><td>TDE</td><td>DCIS</td><td>High grade DCIS</td><td>Mx + ANS</td></tr><tr><td>58</td><td>Fresh blood</td><td>Yes</td><td>TDE</td><td>IDC</td><td>3 mm grade 3 IDC + extensive DCIS</td><td>Mx + ANC + recon</td></tr><tr><td>60</td><td>Fresh blood</td><td>Yes</td><td>Micro</td><td>DCIS</td><td>High grade DCIS</td><td>Mx + ANS</td></tr><tr><td>68</td><td>Fresh blood</td><td>Yes</td><td>TDE</td><td>IDC</td><td>3 mm grade 2 IDC + DCIS</td><td>Mx + ANC</td></tr><tr><td>69</td><td>Fresh blood</td><td>Yes</td><td>Micro</td><td>DCIS</td><td>Multifocal intermediate grade DCIS</td><td>Mx + ANS</td></tr><tr><td>72</td><td>History of fresh blood; serous discharge identified, dipstick +++ for blood</td><td>Yes</td><td>TDE</td><td>IDC</td><td>10 mm grade 2 IDC + DCIS</td><td>Mx+ ANC</td></tr><tr><td>74</td><td>Altered blood</td><td>Yes</td><td>TDE</td><td>IDC</td><td>10 mm grade 2 IDC + widespread DCIS</td><td>Mx and ANC</td></tr><tr><td>78</td><td>Fresh blood</td><td>Yes</td><td>TDE</td><td>DCIS</td><td>Multifocal intermediate grade DCIS</td><td>Simple Mx</td></tr><tr><td>88</td><td>Fresh blood</td><td>Yes</td><td>TDE</td><td>DCIS</td><td>Low grade DCIS</td><td>Simple Mx</td></tr></table>
62ae3ccb67cd1002016b86318600be3a568b42d2dfa9bd78dcdd0103aec687e8.png	complex	<table><tr><td rowspan="2"></td><td>Nonretreatment Group B</td><td>Retreatment Group A</td></tr><tr><td>(<i>N</i> = 106)</td><td>(<i>N</i> = 125)</td></tr><tr><td>Age, years</td><td></td><td></td></tr><tr><td> Mean (SD)</td><td>61.4 (10.00)</td><td>60.8 (10.39)</td></tr><tr><td>Gender, N (%)</td><td></td><td></td></tr><tr><td> Female</td><td>62 (58.5)</td><td>74 (59.2)</td></tr><tr><td> Male</td><td>44 (41.5)</td><td>51 (40.8)</td></tr><tr><td>Body mass index, kg/m<sup>2</sup> (mean ± SD)</td><td>28.4 (4.06)</td><td>28.3 (4.05)</td></tr><tr><td>Kellgren-Lawrence Score - Study Knee [N (%)]</td><td></td><td></td></tr><tr><td> Grade 1</td><td>11 (10.4)</td><td>10 (8.0)</td></tr><tr><td> Grade 2</td><td>46 (43.4)</td><td>42 (33.6)</td></tr><tr><td> Grade 3</td><td>49 (46.2)</td><td>73 (58.4)</td></tr><tr><td>WOMAC pain subscores - Study Knee (mean)</td><td>68.1</td><td>69.0</td></tr></table>
944e938b7676e91654602dd0c7fa67cf05a31330e949fd4d2e9fa6422ebae02d.png	simple	<table><tr><td>Subtype</td><td>OMIM ID</td><td>Causative gene</td><td>HGNC ID</td><td>Cytogenetic location</td><td>Inheritance</td></tr><tr><td>FHL1</td><td>267700</td><td><i>HPLH1</i><sup>a</sup></td><td>HGNC:23824</td><td>9q21.3 - q22</td><td>AR</td></tr><tr><td>FHL2</td><td>603553</td><td><i>PRF1</i></td><td>HGNC:9360</td><td>10q22.1</td><td>AR</td></tr><tr><td>FHL3</td><td>608898</td><td><i>UNC13D</i></td><td>HGNC:23147</td><td>17q25.1</td><td>AR <sup>b</sup></td></tr><tr><td>FHL4</td><td>603552</td><td><i>STX11</i></td><td>HGNC:11429</td><td>6q24.2</td><td>AR</td></tr><tr><td>FHL5</td><td>613101</td><td><i>STXBP2</i></td><td>HGNC:11445</td><td>19p13.2</td><td>AR <sup>b</sup></td></tr><tr><td>XLP1</td><td>308240</td><td><i>SH2D1A</i></td><td>HGNC:10820</td><td>Xq25</td><td>XLR</td></tr><tr><td>XLP2</td><td>300635</td><td><i>XIAP</i></td><td>HGNC:592</td><td>Xq25</td><td>XLR</td></tr></table>
d10941af0c88f64d6de05460182801b978b64f2d2f32c7bc062f1db989f5cdf6.png	simple	<table><tr><td>Clinical symptoms</td><td>PCNSL(NO of patients)</td><td>GBM(NO of patients)</td></tr><tr><td>Organic brain syndrome</td><td>22</td><td>12</td></tr><tr><td>Signs of intracranial hypertension</td><td>16</td><td>23</td></tr><tr><td>Paresis</td><td>16</td><td>19</td></tr><tr><td>Vertigo</td><td>12</td><td>13</td></tr><tr><td>Phatic disorder</td><td>11</td><td>14</td></tr><tr><td>Visual disturbances</td><td>7</td><td>3</td></tr><tr><td>Cranial nerve dysfunction other than visual disturbance</td><td>5</td><td>0</td></tr><tr><td>Fatigue</td><td>4</td><td>7</td></tr><tr><td>Dysesthesia or hypesthesia</td><td>4</td><td>1</td></tr><tr><td>Seizure</td><td>1</td><td>9</td></tr></table>
82c61fbc461655d4f7708fb66783368ac2c5e3fddc390ce0eb6a0a86bee01adc.png	simple	<table><tr><td>Description</td><td>Unit</td><td><i>n</i></td><td>Abbreviation</td></tr><tr><td>Milk yield</td><td>l/day</td><td>285</td><td>dMY</td></tr><tr><td>FMI per visit</td><td>kg/visit</td><td>13,908</td><td>vFMI</td></tr><tr><td>Feeding duration per visit</td><td>s/visit</td><td>13,908</td><td>vFdur</td></tr><tr><td>FMI (fresh matter intake)</td><td>kg/day</td><td>311</td><td>dFMI</td></tr><tr><td>Feeding time</td><td>min/day</td><td>311</td><td>dFtime</td></tr><tr><td>Feeding frequency</td><td>visits/day</td><td>311</td><td>dFfreq</td></tr><tr><td>Mean FMI per visit</td><td>kg/visit</td><td>311</td><td>mvFMI</td></tr><tr><td>Mean feeding duration per visit</td><td>s/visit</td><td>311</td><td>mvFdur</td></tr><tr><td>Daily feeding rate</td><td>g/min</td><td>311</td><td>dFR</td></tr><tr><td>Cow feeding rate</td><td>g/min</td><td>16</td><td>cFR</td></tr><tr><td>Rumination duration per event</td><td>min/event</td><td>7,697</td><td>eRUMdur</td></tr><tr><td>Rumination time</td><td>min/day</td><td>311</td><td>dRUMtime</td></tr><tr><td>Rumination frequency</td><td>events/day</td><td>311</td><td>dRUMfreq</td></tr><tr><td>Mean rumination duration</td><td>min/event</td><td>311</td><td>meRUMdur</td></tr></table>
0c99219a0278a94fc66af7dbdbb229212ff5dcd1827932d034712ca1656740d1.png	simple	<table><tr><td>Characteristics<sup>a</sup></td><td>Cases(n = 1760)</td><td>Controls(n = 2481)</td></tr><tr><td></td><td>No. (%)</td><td>No. (%)</td></tr><tr><td>Age (years)</td><td></td><td></td></tr><tr><td> 18-49</td><td>368(20.9)</td><td>265(10.7)</td></tr><tr><td> 50-59</td><td>412(23.4)</td><td>690(27.8)</td></tr><tr><td> 60-69</td><td>646(36.7)</td><td>998(40.2)</td></tr><tr><td> 70+</td><td>334(19.0)</td><td>528(21.3)</td></tr><tr><td>Sex</td><td></td><td></td></tr><tr><td> Males</td><td>935(53.1)</td><td>1357(54.7)</td></tr><tr><td> Females</td><td>825(46.9)</td><td>1124(45.3)</td></tr><tr><td>Province of residence</td><td></td><td></td></tr><tr><td> NL</td><td>488(27.7)</td><td>651(26.2)</td></tr><tr><td> ON</td><td>1272(72.3)</td><td>1830(73.8)</td></tr><tr><td>BMI<sup>b </sup>(kg/m<sup>2</sup>)</td><td></td><td></td></tr><tr><td> Underweight(< 18.5)</td><td>23(1.3)</td><td>22(0.9)</td></tr><tr><td> Normal(18.5-24.9)</td><td>595(33.8)</td><td>930(37.5)</td></tr><tr><td> Overweight (25-29.9)</td><td>748(42.5)</td><td>1069(43.1)</td></tr><tr><td> Obese(≥ 30)</td><td>394(22.4)</td><td>460(18.5)</td></tr><tr><td>Physical activity (METs/week<sup>b</sup>)</td><td></td><td></td></tr><tr><td> 0 - 7.4</td><td>465(26.4)</td><td>595(24.0)</td></tr><tr><td> 7.4 - 22.4</td><td>348(19.8)</td><td>633(25.5)</td></tr><tr><td> 22.4 - 53.0</td><td>429(24.4)</td><td>633(25.5)</td></tr><tr><td> > 53.0</td><td>518(29.4)</td><td>620(25.0)</td></tr><tr><td>Family history of CRC</td><td></td><td></td></tr><tr><td> No</td><td>1582(89.9)</td><td>2337(94.2)</td></tr><tr><td> Yes</td><td>178(10.1)</td><td>144(5.8)</td></tr><tr><td>Reported any colon screening procedure</td><td></td><td></td></tr><tr><td> No</td><td>1500(85.2)</td><td>1861(75.0)</td></tr><tr><td> Yes</td><td>260(14.8)</td><td>620(25.0)</td></tr><tr><td>Regular use of NSAID<sup>b</sup></td><td></td><td></td></tr><tr><td> No</td><td>1163(66.1)</td><td>1439(58.0)</td></tr><tr><td> Yes</td><td>597(33.9)</td><td>1042(42.0)</td></tr><tr><td>Education attainment</td><td></td><td></td></tr><tr><td> High school graduate or less</td><td>884(50.2)</td><td>1042(42.0)</td></tr><tr><td> Technical school/some college/university</td><td>540(30.7)</td><td>866(34.9)</td></tr><tr><td> Bachelor's degree/graduate degree</td><td>336(19.1)</td><td>573(23.1)</td></tr><tr><td>Household income ($CAN)</td><td></td><td></td></tr><tr><td> < 12,000</td><td>109(6.2)</td><td>154(6.2)</td></tr><tr><td> 12,000-29,999</td><td>507(28.8)</td><td>573(23.1)</td></tr><tr><td> 30,000-49,999</td><td>547(31.1)</td><td>777(31.3)</td></tr><tr><td> ≥ 50,000</td><td>597(33.9)</td><td>977(39.4)</td></tr></table>
7565271b28fe601432830e841eb4fb3624d4010f4387d9da5af41159756c4139.png	simple	<table><tr><td>Downregulated Pathways</td><td>Fat</td><td>Liver</td><td>Muscle</td><td>Comments</td></tr><tr><td>Steroid Biosynthesis</td><td></td><td>Q; EQ</td><td></td><td>Target of Statins</td></tr><tr><td>Phagocytosis/ leukocyte extravasation</td><td>EQ</td><td></td><td></td><td>Innate Immune Response</td></tr><tr><td>EIF2 signaling</td><td></td><td></td><td>Q; EQ</td><td>Stress Response</td></tr><tr><td>Mitochondrial dysfunction</td><td></td><td></td><td>Q</td><td>Associated with disease</td></tr><tr><td>eIF4/p70S6K signaling</td><td></td><td></td><td>Q; EQ</td><td>Insulin Signaling</td></tr><tr><td>Oxidative phosphorylation</td><td></td><td></td><td>Q; EQ</td><td>Energy Production</td></tr><tr><td>PPARα/RXRα activation</td><td></td><td></td><td>Q</td><td>Gene Expression</td></tr></table>
91ae8123e07455f33365b36497346b24380438c9bfdc154d60237bfee1473fbd.png	complex	<table><tr><td></td><td colspan="3">Termamyl</td></tr><tr><td>Parameter</td><td>Model (5) versus model (1)</td><td>Model (6) versus model (1)</td><td>Model (7) versus model (1)</td></tr><tr><td rowspan="3"><i>v</i><sub>max⁡</sub></td><td><i>t</i> value = −2.874</td><td><i>t</i> value = −3.214</td><td><i>t</i> value = −3.327</td></tr><tr><td><i>P</i> value = 0.045</td><td><i>P</i> value = 0.032</td><td><i>P</i> value = 0.029</td></tr><tr><td>D.F. = 4</td><td>D.F. = 4</td><td>D.F. = 4</td></tr><tr><td rowspan="3"><i>K</i><sub><i>M</i></sub></td><td><i>t</i> value = −1.921</td><td><i>t</i> value = −1.873</td><td><i>t</i> value = −1.683</td></tr><tr><td><i>P</i> value = 0.127</td><td><i>P</i> value = 0.134</td><td><i>P</i> value = 0.168</td></tr><tr><td>D.F. = 4</td><td>D.F. = 4</td><td>D.F. = 4</td></tr><tr><td></td><td colspan="3">San Super</td></tr><tr><td>Parameter</td><td>Model (5) versus model (1)</td><td>Model (6) versus model (1)</td><td>Model (7) versus model (1)</td></tr><tr><td rowspan="3"><i>v</i><sub>max⁡</sub></td><td><i>t</i> value = −2.582</td><td><i>t</i> value = −2.053</td><td><i>t</i> value = −3.179</td></tr><tr><td><i>P</i> value = 0.061</td><td><i>P</i> value = 0.109</td><td><i>P</i> value = 0.033</td></tr><tr><td>D.F. = 4</td><td>D.F. = 4</td><td>D.F. = 4</td></tr><tr><td rowspan="3"><i>K</i><sub><i>M</i></sub></td><td><i>t</i> value = −1.982</td><td><i>t</i> value = −1.895</td><td><i>t</i> value = −1.778</td></tr><tr><td><i>P</i> value = 0.118</td><td><i>P</i> value = 0.131</td><td><i>P</i> value = 0.150</td></tr><tr><td>D.F. = 4</td><td>D.F. = 4</td><td>D.F. = 4</td></tr><tr><td></td><td colspan="3">BAN</td></tr><tr><td>Parameter</td><td>Model (5) versus model (1)</td><td>Model (6) versus model (1)</td><td>Model (7) versus model (1)</td></tr><tr><td rowspan="3"><i>v</i><sub>max⁡</sub></td><td><i>t</i> value = −2.301</td><td><i>t</i> value = −2.182</td><td><i>t</i> value = −2.089</td></tr><tr><td><i>P</i> value = 0.083</td><td><i>P</i> value = 0.094</td><td><i>P</i> value = 0.105</td></tr><tr><td>D.F. = 4</td><td>D.F. = 4</td><td>D.F. = 4</td></tr><tr><td rowspan="3"><i>K</i><sub><i>M</i></sub></td><td><i>t</i> value = −0.689</td><td><i>t</i> value = −0.638</td><td><i>t</i> value = −0.577</td></tr><tr><td><i>P</i> value = 0.529</td><td><i>P</i> value = 0.558</td><td><i>P</i> value = 0.595</td></tr><tr><td>D.F. = 4</td><td>D.F. = 4</td><td>D.F. = 4</td></tr></table>
a32eeea8f47597dbac240a5049bc56235803cf58d1f063e75fa91b825d7f6c82.png	complex	<table><tr><td colspan="6">Health Care Providers</td></tr><tr><td rowspan="2">Unqualified providers (UQP)</td><td colspan="2">Yes</td><td rowspan="2">Qualified Providers (QP)</td><td colspan="2">Yes</td></tr><tr><td>n</td><td>%</td><td>n</td><td>%</td></tr><tr><td>Village doctor</td><td>416</td><td>92.7</td><td>Public</td><td> </td><td> </td></tr><tr><td>Drug stores</td><td>341</td><td>75.9</td><td>Upazila Health Complex</td><td>136</td><td>30.3</td></tr><tr><td>Self-medication</td><td>302</td><td>67.3</td><td>Union Health/Satellite Clinic</td><td>100</td><td>22.3</td></tr><tr><td>FWA/FWV/Nurses</td><td>161</td><td>35.9</td><td>Private</td><td> </td><td> </td></tr><tr><td>Medical assistant</td><td>39</td><td>8.7</td><td>Private clinic</td><td>160</td><td>35.5</td></tr><tr><td>Homeopath</td><td>158</td><td>35.2</td><td>Paramedics</td><td>266</td><td>59.1</td></tr><tr><td>Spiritual treatment</td><td>94</td><td>20.9</td><td> </td><td> </td><td> </td></tr><tr><td>Folk medicine</td><td>142</td><td>31.6</td><td> </td><td> </td><td> </td></tr><tr><td>n=number</td><td> </td><td> </td><td> </td><td> </td><td> </td></tr></table>
44df6a53886dd442961e8cd3e4ea024d15236809a22688fb11b72af793c6013b.png	simple	<table><tr><td></td><td><i>No CAD (%) (n = 15)</i></td><td><i>CAD (%) (n = 38)</i></td></tr><tr><td>Hypertension (blood pressure > 140/90 mmHg or on antihypertensive therapy)</td><td>60</td><td>97</td></tr><tr><td>Increased abdominal circumference (male > 92 cm, females > 88 cm)</td><td>33.3</td><td>79.1</td></tr><tr><td>Abnormal glucose tolerance</td><td>0</td><td>55.26</td></tr><tr><td>Raised triglycerides (> 1.7 mmol/l)</td><td>26.7</td><td>50</td></tr><tr><td>Low HDL cholesterol (men < 1.0 mmol/l, women < 1.3 mmol/l)</td><td>33.33</td><td>42.10</td></tr><tr><td>Raised LDL cholesterol (> 3 mmol/l)</td><td>13.33</td><td>42.10</td></tr><tr><td>Cigarette smoking/previous smokers</td><td>20</td><td>62.5</td></tr><tr><td>Mean CIMT (mm)</td><td>0.998</td><td>1.13</td></tr><tr><td>Increased CIMT (> 0.8 mm)</td><td>53</td><td>76</td></tr></table>
53e1bf6d8a2e02ded0e84c83d37a6486bee4ff385c40e239e2556974fa6211ac.png	complex	<table><tr><td>(<i>N</i> = 24)</td><td colspan="2"> Distance from the bladder neck</td><td>Distance from the echolucent urethral lumen</td></tr><tr><td> </td><td>[mm]</td><td>% of urethral length</td><td>[mm]</td></tr><tr><td>Mean</td><td>19.43</td><td>64.9%</td><td>3.13</td></tr><tr><td>Median</td><td>19.00</td><td>64.5%</td><td>3.30</td></tr><tr><td>Std. dev.</td><td>3.19</td><td>6.9%</td><td>0.94</td></tr></table>
acbbfca8df8d21024b1462b735c53f22cc5e1ae6db7d985b19f842a062be47b8.png	simple	<table><tr><td>Parameter</td><td>Control (n=56)</td><td>Oil refinery workers (n=56)</td><td>p-value</td></tr><tr><td>Age (years)</td><td>30.02±1.76</td><td>35.20±1.62</td><td>0.320</td></tr><tr><td>Height (cm)</td><td>174±0.93</td><td>170.75±0.83</td><td>0.100</td></tr><tr><td>Weight (kg)</td><td>80.25±2.68</td><td>78.36±1.55</td><td>0.543</td></tr><tr><td>FVC (lit)</td><td>5.21±0.15</td><td>4.76±0.20</td><td>0.083</td></tr><tr><td>FEV1 (lit/sec)</td><td>3.99±0.14</td><td>3.08±0.16</td><td>0.0001</td></tr><tr><td>FEV1/FVC (%)</td><td>76.66±2.01</td><td>67.19±3.15</td><td>0.013</td></tr><tr><td>PEF (lit/ sec)</td><td>6.89±0.34</td><td>4.80±0.37</td><td>0.0001</td></tr><tr><td>FEF 25% (lit/sec)</td><td>6.39±0.33</td><td>4.45±0.36</td><td>0.0001</td></tr><tr><td>FEF 50% (lit/sec)</td><td>4.62±0.25</td><td>3.65±0.28</td><td>0.012</td></tr><tr><td>FEF 75% (lit/sec)</td><td>2.24±0.16</td><td>1.92±0.15</td><td>0.151</td></tr></table>
59b32736ba638d38d6e1e02d8c14bd795822e922bcd1e92acc6ddd49b8a9e2cb.png	complex	<table><tr><td rowspan="3"></td><td colspan="7">Response options for doctors and researchers<sup>b</sup></td><td></td></tr><tr><td>Benefit</td><td></td><td></td><td></td><td>Harm</td><td></td><td></td><td></td></tr><tr><td>A great deal</td><td>Quite a lot</td><td>Only a little</td><td>No benefit or harm</td><td>Only a little</td><td>Quite a lot</td><td>A great deal</td><td></td></tr><tr><td colspan="9">Criteria for doctors and researchers</td></tr><tr><td>1. Significant discussion<sup>a</sup> or other intervention that presumably reduces other health care use</td><td>x</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>2. Need to contact child welfare</td><td>x</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>3. Some referrals to secondary care</td><td>x</td><td>x</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>4. Doctor’s role irreplaceable by nurse</td><td></td><td>x</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>5. Presumably reduced concern<sup>b</sup></td><td></td><td>x</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>6. Some significant discussions<sup>b</sup></td><td></td><td>x</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>7. Nurse could have replaced the doctor</td><td></td><td></td><td>x</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>8. No significant harm as consequence of unhandled concerns</td><td></td><td></td><td>x</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>9. Suspicion that interaction failed or suspicion of no progress in care</td><td></td><td></td><td></td><td></td><td>x</td><td></td><td></td><td></td></tr><tr><td>10. The interaction failed or here was no progress in care</td><td></td><td></td><td></td><td></td><td></td><td>x</td><td></td><td></td></tr><tr><td>11. Suspicion of negative PREM or refusal of school doctor services in the future and no progress in care</td><td></td><td></td><td></td><td></td><td></td><td></td><td>x</td><td></td></tr><tr><td colspan="9">PREM question</td></tr><tr><td>How much benefit or harm did you perceive from the school doctor’s health check?</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>I don’t know</td></tr><tr><td>Response options for parents</td><td>x</td><td>x</td><td>x</td><td>x</td><td>x</td><td>x</td><td>x</td><td>x</td></tr><tr><td>Response options for children</td><td></td><td>x</td><td>x</td><td>x</td><td>x</td><td>x</td><td></td><td></td></tr></table>
113250e038d664ea1c3272628697f81e2dc7aa766491803a6c57ec4a1d97c8b5.png	simple	<table><tr><td>Source</td><td>A lot</td><td>A fair amount</td><td>A little</td><td>Almost none</td></tr><tr><td>Chicago City Health Department</td><td>9.5</td><td>21.4</td><td>33.3</td><td>35.7</td></tr><tr><td>Chicago Housing Authority</td><td>9.5</td><td>14.3</td><td>23.8</td><td>52.4</td></tr><tr><td>Doctor</td><td>19.1</td><td>14.3</td><td>21.4</td><td>45.2</td></tr><tr><td>Friends and relatives</td><td>31.0</td><td>14.3</td><td>28.6</td><td>26.2</td></tr><tr><td>Illinois Department of Health</td><td>16.7</td><td>19.1</td><td>21.4</td><td>42.9</td></tr><tr><td>Newspaper</td><td>21.4</td><td>21.4</td><td>40.5</td><td>16.7</td></tr><tr><td>People for Community Recovery (PCR)</td><td>45.2</td><td>21.4</td><td>21.4</td><td>11.9</td></tr><tr><td>Private industry, such as Waste Management or Ford Motor Company</td><td>9.5</td><td>7.1</td><td>19.1</td><td>64.3</td></tr><tr><td>Radio</td><td>21.4</td><td>14.3</td><td>21.4</td><td>42.9</td></tr><tr><td>Television</td><td>31.0</td><td>28.6</td><td>33.3</td><td>7.1</td></tr><tr><td>U.S. Environmental Protection Agency</td><td>-</td><td>40.5</td><td>28.6</td><td>30.9</td></tr><tr><td>University/College scientists</td><td>4.8</td><td>26.2</td><td>33.3</td><td>35.7</td></tr></table>
5846c08439721d16b142aea8db951f6a2359c4a032a04e5f7ed4c17514b2c8e7.png	complex	<table><tr><td rowspan="2">Species</td><td colspan="3">Whole wing</td><td colspan="3">Red band</td></tr><tr><td><i>t</i></td><td><i>df</i></td><td><i>p</i></td><td><i>t</i></td><td><i>df</i></td><td><i>p</i></td></tr><tr><td><i>H. erato phyllis</i></td><td>0.46</td><td>57.18</td><td>.65</td><td>0.30</td><td>52.82</td><td>.77</td></tr><tr><td><i>H. besckei</i></td><td>0.76</td><td>52.34</td><td>.45</td><td>−4.10</td><td>47.80</td><td>.0002a</td></tr><tr><td><i>H. melpomene burchelli</i></td><td>0.39</td><td>32.86</td><td>.70</td><td>−2.00</td><td>40.40</td><td>.05a</td></tr><tr><td><i>H. melpomene nanna</i></td><td>0.39</td><td>48.31</td><td>.70</td><td>−3.22</td><td>50.28</td><td>.002a</td></tr></table>
932c12f7b65c7f5b1350a435c89daa4631381fa2f9a3317cebf2275c29a436d5.png	simple	<table><tr><td>Appendix I: Key Economic Variables</td><td></td><td>Reference/Data Source</td></tr><tr><td>ECONOMIC</td><td></td><td></td></tr><tr><td>Annual Discount Rate</td><td>3%</td><td>27</td></tr><tr><td>Exchange Rate: Shekels to USD (2005)</td><td>4.35</td><td>12</td></tr><tr><td>Per capita GDP (USD 2003)</td><td>$16,497</td><td>12</td></tr><tr><td>Training Staff</td><td></td><td></td></tr><tr><td>Number of Clinics in Israel</td><td>3000</td><td>MOH Statistical Dept.</td></tr><tr><td>Staff per clinic receiving training</td><td>2</td><td>Ashkelon Project</td></tr><tr><td>Full Days Training in initial year</td><td>2</td><td>Ashkelon Project</td></tr><tr><td>Days training in subsequent years</td><td>1</td><td>Ashkelon Project</td></tr><tr><td>Cost per ticipant-day of training course</td><td>$100</td><td>Ashkelon Project</td></tr><tr><td>Tele-management & Operational costs per patient.</td><td>$60</td><td>Ashkelon Project</td></tr><tr><td>Nurse/GP guidance per patient in first year of program</td><td>$230</td><td>Ashkelon Project</td></tr><tr><td>Unit Care Costs</td><td></td><td></td></tr><tr><td>Ambulatory visit to Nurse or Nutritionist</td><td>$7.83</td><td>15 mins visit & 5 mins secretarial time</td></tr><tr><td>Ambulatory GP visit</td><td>$11.37</td><td>15 mins GP & 5 mins secretarial time</td></tr><tr><td>Cost of OPV</td><td>$99.14</td><td>25% of general hospital cost (30)</td></tr><tr><td>General Hospital Cost per day</td><td>$397</td><td>30</td></tr><tr><td>ICU cost per day</td><td>$1,586</td><td>estimated as four times general per diem cost (30)</td></tr><tr><td>Rehabilitation Hospital Cost per day</td><td>$238.85</td><td>30</td></tr><tr><td>Home Physiotherapy Visit</td><td>$38.53</td><td>30</td></tr><tr><td>Devices and Procedure costs</td><td></td><td></td></tr><tr><td>Stent</td><td>$202</td><td>Barzelai Hospital Accounts Dept.</td></tr><tr><td>Cypher</td><td>$2,989</td><td>Barzelai Hospital Accounts Dept.</td></tr><tr><td>Diagnostic Catheterisation</td><td>$2,464</td><td>30</td></tr><tr><td>Restenosis</td><td>$9,701</td><td>30, includes 1 day in ICU & 3 days in cardiac ward</td></tr><tr><td>Average cost of Catheterisation with Stent or cypher</td><td>$6,925</td><td>30</td></tr><tr><td>CABG operation</td><td>$12,740</td><td>30</td></tr><tr><td>TPA</td><td>$1,800</td><td>30 estimated as four times general per diem cost</td></tr><tr><td>PRS Streptokinaise</td><td>$81</td><td>31</td></tr><tr><td>Kidney Transplant Cost</td><td>$39,132</td><td>30</td></tr><tr><td>Haemodialysis cost</td><td>$313</td><td>30</td></tr><tr><td>Peritonea dialysis cost</td><td>$136</td><td>30</td></tr><tr><td>% receiving haemodialysis</td><td>88.8%</td><td>20</td></tr><tr><td>Average annual Dialysis Cost</td><td>$46,041</td><td>30</td></tr><tr><td>Drug Costs</td><td></td><td></td></tr><tr><td>Post-MI or stroke drugs per day per patient- Males</td><td>$1.92</td><td>14</td></tr><tr><td>Post-MI or stroke drugs per day per patient- Females</td><td>$1.79</td><td>14</td></tr><tr><td>Post-UAP drugs per day per patient- Males</td><td>$1.92</td><td>14</td></tr><tr><td>Post-UAP drugs per day per patient- Females</td><td>$1.79</td><td>14</td></tr><tr><td>Correct preventive medication per day</td><td>$0.92</td><td>14, Ace inhibitor, Aspirin & Statin</td></tr><tr><td>Inadequate preventive medication per day</td><td>$0.31</td><td>14, Assumed only 1 correct drug taken</td></tr></table>
8e3f39f15fed47271ed821b537bd2a65cbef1633786a377542b37f67f8985b61.png	simple	<table><tr><td>First author (public year) [Reference]</td><td>Experimental animal</td><td>Inoculum spores</td><td>Inoculation route</td><td>Outcome</td><td>Results</td></tr><tr><td>Kawai (2012) [2]</td><td>4-5-d old ddY mouse</td><td><i>Kudoa septempunctata</i></td><td>Oral</td><td>Bowel movements and FAR</td><td>Showing diarrheagenic activity (11/17) and significantly higher FAR</td></tr><tr><td>Ahn (2015) [6]</td><td>6-wk old BALB/c mice</td><td><i>Kudoa septempunc-tata</i></td><td>Oral</td><td>Bowl movements and histo-pathological examination</td><td>No significant diarrhea (0/32) and histopathologic changes (0/24)</td></tr><tr><td>Jang (2016) [7]</td><td>4-5-d old ddY mouse</td><td><i>Kudoa septempunc-tata</i></td><td>Oral</td><td>Bowel movements and FAR</td><td>No watery stool form (0/20) and no significant variations in FAR</td></tr><tr><td>Guo (2015) [8]</td><td>4-5-d old BALB/c suckling mice</td><td><i>Myxobolus hongh-uensis</i></td><td>Oral</td><td>Bowel movements, FAR, and histopathology</td><td>No significant change of FAR, no abnormal stool form (0/25) and no evidence of inflammation (0/25)</td></tr></table>
35424e6e53323314721d3938419ad2c941765a517aa51acfbaa99c4f89609abd.png	complex	<table><tr><td> </td><td colspan="2">AMR</td><td colspan="2">AMR + PLR</td><td colspan="2">Total</td></tr><tr><td>Stage</td><td>Age (SD)/No.</td><td>F/M (Ratio)</td><td>Age (SD)/No.</td><td>F/M (Ratio)</td><td>Age (SD)/No.</td><td>F/M (Ratio)</td></tr><tr><td>I</td><td>52 (9)/37</td><td>30/7 (4.3)</td><td>55 (10)/12</td><td>11/1 (11)</td><td>53 (9)/49</td><td>41/8 (5.1)</td></tr><tr><td>II</td><td>58 (11)/163</td><td>123/40 (3.1)</td><td>59 (11)/47</td><td>43/4 (10.8)</td><td>58 (11)/210</td><td>166/44 (3.8)</td></tr><tr><td>III</td><td>64 (8)/170</td><td>147/23 (6.4)</td><td>63 (5)/37</td><td>32/5 (6.4)</td><td>64 (7)/207</td><td>179/28 (4.6)</td></tr><tr><td>IV</td><td>62 (7)/36</td><td>30/6 (5.0)</td><td>66 (1)/3</td><td>3/0 (NA)</td><td>62 (7)/39</td><td>33/6 (5.5)</td></tr><tr><td>Total</td><td>60 (9)/406</td><td>330/76 (4.3)</td><td>64 (11)/99</td><td>89/10 (8.9)</td><td>60 (10)/505</td><td>419/86 (4.9)</td></tr><tr><td> </td><td colspan="2">p<0.0001, R<sup>2</sup>=0.15</td><td colspan="2">p=0.019, R<sup>2</sup>=0.07</td><td colspan="2">p<0.0001, R<sup>2</sup>=0.13</td></tr></table>
5640f1ef6a4c1d4d9836b9443c0aa61e7a7423999ec9615001ff7de16a75725f.png	simple	<table><tr><td>MIGS ID</td><td>Property</td><td>Term</td></tr><tr><td>MIGS-31</td><td>Finishing quality</td><td>High quality draft</td></tr><tr><td>MIGS-28</td><td>Libraries used</td><td>IonTorrent 100 bp and 400 bp single end reads</td></tr><tr><td>MIGS-29</td><td>Sequencing platforms</td><td>IonTorrent PGM</td></tr><tr><td>MIGS-31.2</td><td>Fold coverage</td><td>110×</td></tr><tr><td>MIGS-30</td><td>Assemblers</td><td>Newbler 2.6, MIRA 3.9.18, Sequencher 5.0.1</td></tr><tr><td>MIGS-32</td><td>Gene calling method</td><td>Prodigal</td></tr><tr><td> </td><td>Locus Tag</td><td>M670</td></tr><tr><td> </td><td>Genbank ID</td><td>JJRY00000000</td></tr><tr><td> </td><td>Genbank Date of Release</td><td>2014-06-16</td></tr><tr><td> </td><td>GOLD ID</td><td>Gi0050495</td></tr><tr><td> </td><td>BIOPROJECT</td><td>PRJNA209301</td></tr><tr><td> </td><td>Project relevance</td><td>Environmental, co-denitrification</td></tr><tr><td>MIGS 13</td><td>Source Material Identifier</td><td>LMG 28302</td></tr></table>
5be04b88de8886bfeb707197293157fcf3b814fc515beac21a10fd7768ecdc16.png	complex	<table><tr><td rowspan="2">Clinicopathological features</td><td colspan="4">GPx3 expression level (n)</td></tr><tr><td>Number</td><td>Down regulated</td><td>Non-down regulated</td><td><i>P</i></td></tr><tr><td>Sex</td><td></td><td></td><td></td><td rowspan="3">0.210</td></tr><tr><td> Male</td><td>92</td><td>43</td><td>49</td></tr><tr><td> Female</td><td>21</td><td>13</td><td>8</td></tr><tr><td>Age</td><td></td><td></td><td></td><td rowspan="3">0.926</td></tr><tr><td> Younger than 55</td><td>57</td><td>28</td><td>29</td></tr><tr><td> Older than 55</td><td>56</td><td>28</td><td>28</td></tr><tr><td>pTNM stage<sup>a</sup></td><td></td><td></td><td></td><td rowspan="3">0.024 </td></tr><tr><td> Early stage (1-2)</td><td>29</td><td>9</td><td>20</td></tr><tr><td> Advanced stage (3-4)</td><td>83</td><td>46</td><td>37</td></tr><tr><td>Venous infiltration</td><td></td><td></td><td></td><td rowspan="3">0.043 </td></tr><tr><td> Absent</td><td>47</td><td>18</td><td>29</td></tr><tr><td> Present</td><td>66</td><td>38</td><td>28</td></tr><tr><td>Tumor size<sup>a</sup></td><td></td><td></td><td></td><td rowspan="3">0.462</td></tr><tr><td> Less than 5 cm</td><td>47</td><td>25</td><td>22</td></tr><tr><td> More than 5 cm</td><td>65</td><td>30</td><td>35</td></tr><tr><td>Tumor Nodules<sup>a</sup></td><td></td><td></td><td></td><td rowspan="3">0.448</td></tr><tr><td> Less than 3</td><td>83</td><td>39</td><td>44</td></tr><tr><td> More than 3</td><td>29</td><td>16</td><td>13</td></tr><tr><td>HBsAg</td><td></td><td></td><td></td><td rowspan="3">0.794</td></tr><tr><td> Negative</td><td>13</td><td>6</td><td>7</td></tr><tr><td> Positive</td><td>100</td><td>50</td><td>50</td></tr><tr><td>AFP level<sup>a</sup></td><td></td><td></td><td></td><td rowspan="3">0.006 </td></tr><tr><td> Lower than 20 ng/mL</td><td>45</td><td>15</td><td>30</td></tr><tr><td> Higher than 20 ng/mL</td><td>67</td><td>40</td><td>27</td></tr><tr><td>One year recurrence<sup>a</sup></td><td></td><td></td><td></td><td rowspan="3">0.038</td></tr><tr><td> Recurrence</td><td>42</td><td>27</td><td>15</td></tr><tr><td> Non-recurrence</td><td>62</td><td>27</td><td>35</td></tr><tr><td>Five year recurrence<sup>a</sup></td><td></td><td></td><td></td><td rowspan="3">0.019*</td></tr><tr><td> Recurrence</td><td>62</td><td>36</td><td>26</td></tr><tr><td> Non-recurrence</td><td>43</td><td>15</td><td>28</td></tr></table>
d6f8eea7e40ef304e1f34f809fa0593e9b009adb0e2da1724f5b38dbcdb13944.png	simple	<table><tr><td> </td><td>n</td><td>1 (<=0.90)</td><td>2 (0.91–1.07)</td><td>3 (1.08–1.27)</td><td>4 (>1.27)</td><td>P trend</td></tr><tr><td>Frailty</td><td>30</td><td>1.00</td><td>4.27 (0.66–27.60)</td><td>1.27 (0.22–7.74)</td><td>1.90 (0.36–9.88)</td><td>0.887</td></tr><tr><td>Pre-frailty</td><td>79</td><td>1.00</td><td>0.81 (0.30–2.24)</td><td>0.60 (0.23–1.56)</td><td>1.64 (0.50–5.35)</td><td>0.648</td></tr><tr><td>Weight loss</td><td>16</td><td>1.00</td><td>0.93 (0.18–4.78)</td><td>1.03 (0.20–5.31)</td><td>0.43 (0.09–2.18)</td><td>0.394</td></tr><tr><td>Exhaustion</td><td>43</td><td>1.00</td><td>2.02 (0.66–6.18)</td><td>1.10 (0.34–3.48)</td><td>1.76 (0.63–4.94)</td><td>0.428</td></tr><tr><td>Low hand grip strength</td><td>76</td><td>1.00</td><td>0.86 (0.33–2.28)</td><td>0.34 (0.13–0.88)</td><td>0.70 (0.27–1.79)</td><td>0.182</td></tr><tr><td>Slow walking speed</td><td>43</td><td>1.00</td><td>5.66 (1.17–27.42)</td><td>2.13 (0.48–9.58)</td><td>4.19 (0.94–18.71)</td><td>0.188</td></tr><tr><td>Low physical activity</td><td>39</td><td>1.00</td><td>0.90 (0.30–2.66)</td><td>0.43 (0.14–1.36)</td><td>0.37 (0.12–1.13)</td><td>0.021*</td></tr></table>
46e146b8ef65c99339e0aa2534c52e0f8f5e6e4dc0d462733cf52c63e0a2aae2.png	simple	<table><tr><td>Medicine</td><td>MIC (mg/L)</td></tr><tr><td>AMPH-B</td><td>0.5</td></tr><tr><td>5-FC</td><td><=0.12</td></tr><tr><td>MCZ</td><td>0.12</td></tr><tr><td>FLCZ</td><td>0.25</td></tr><tr><td>ITCZ</td><td>0.06</td></tr><tr><td>MCFG</td><td>0.12</td></tr><tr><td>VRCZ</td><td><=0.015</td></tr></table>
bc2cd3122005966407cd9553c8365c9166904a065f7941e8d203d9e94c6b1010.png	simple	<table><tr><td> </td><td> CFC </td><td> WCM </td><td> MRC </td><td> SSC </td><td> RF </td><td> OMCR</td></tr><tr><td>AOM </td><td> 65.6 </td><td> 65.5 </td><td> 61.0 </td><td> 76.2 </td><td> 80.3 </td><td> 90.0 </td></tr><tr><td> OME </td><td> 56.7 </td><td> 58.2 </td><td> 65.3 </td><td> 72.8 </td><td> 79.1 </td><td> 89.1 </td></tr><tr><td> NOE </td><td> 71.4 </td><td> 69.0 </td><td> 83.9 </td><td> 58.3 </td><td> 69.4 </td><td> 93.2</td></tr><tr><td>Accuracy </td><td> 63.6 </td><td> 63.6 </td><td> 68.2 </td><td> 70.0 </td><td> 77.1 </td><td>89.9</td></tr></table>
32bbe07f75cef1c0d942b89105c0e00339428afa27f526fda15f49677cdcdc17.png	simple	<table><tr><td>Population</td><td>Frequency (%)</td><td>Number of subjects</td><td>Reference</td></tr><tr><td>African American</td><td>20</td><td>50</td><td>[48]</td></tr><tr><td>African American</td><td>36</td><td>85</td><td>[49]</td></tr><tr><td>African American</td><td>34</td><td>93</td><td>[152]</td></tr><tr><td>Tanzanians</td><td>36</td><td>95</td><td>[153]</td></tr><tr><td>Malawians</td><td><sup>∧</sup>31 (15)</td><td>26</td><td>[60]</td></tr><tr><td>Ghanaians</td><td>46</td><td>42</td><td>[152]</td></tr><tr><td>Ghanaians</td><td>25</td><td>800</td><td>[78]</td></tr><tr><td>Ethiopians</td><td><sup>∧</sup>45.5 (8.7)</td><td>262</td><td>[45]</td></tr><tr><td>Ivory coast</td><td>38</td><td>41</td><td>[152]</td></tr><tr><td>Sierra Leone</td><td>36</td><td>52</td><td>[152]</td></tr><tr><td>Senegal</td><td>60</td><td>10</td><td>[152]</td></tr><tr><td>Guinea</td><td>48</td><td>21</td><td>[152]</td></tr><tr><td>West Africa</td><td>42</td><td>166</td><td>[152]</td></tr><tr><td>West Africa</td><td>50</td><td>153</td><td>[49]</td></tr><tr><td>Yoruba (Ibadan, Nigeria)</td><td>35</td><td>78</td><td>[49]</td></tr><tr><td>South Africa</td><td><sup>∧</sup>41 (23)</td><td>80</td><td>[154]</td></tr><tr><td>Xhosa (South Africa)</td><td><sup>∧∧</sup>17</td><td>109</td><td>[155]</td></tr><tr><td>CMA (South Africa)</td><td><sup>∧∧</sup>9</td><td>67</td><td>[155]</td></tr><tr><td>Botswana</td><td>36.6</td><td>101</td><td>[156]</td></tr><tr><td>Zimbabwe</td><td>49</td><td>71</td><td>[76]</td></tr><tr><td>Uganda</td><td>35.6</td><td>121</td><td>[63]</td></tr><tr><td>Uganda</td><td>29</td><td>7 males</td><td>[13]</td></tr><tr><td>Mozambique</td><td>7</td><td>78</td><td>[14]</td></tr></table>
c0a0eb1bb27e1062dbdcf333f3d3aef2e1ac8b0ece93dafb9aeac6e7bb19a9ec.png	complex	<table><tr><td>Study</td><td>n</td><td>n COPD patients</td><td>n controls</td><td>Age (mean ± SD)</td><td>FEV1 (L) (mean ± SD)</td><td>FEV1/FVC% (mean ± SD)</td><td>Pack-years (mean ± SD)</td><td>%Current smoker</td><td>% Female</td></tr><tr><td rowspan="2">Qiu et al.[23]</td><td>1085</td><td>620</td><td>325</td><td>57.3 ± 8.1</td><td>N/A</td><td>54.4 ± 19.8</td><td>41.7 ± 26.2</td><td>36.5</td><td>45.6</td></tr><tr><td>369</td><td>181</td><td>109</td><td>47.5 ± 7.1</td><td>N/A</td><td>54.3 ± 21.1</td><td>28.7 ± 23.6</td><td>27.9</td><td>64</td></tr><tr><td>Bell et al. [22]</td><td>172</td><td>N/A</td><td>N/A</td><td>57.2 ± 8.2</td><td>2.46 ± 0.46</td><td>N/A</td><td>N/A</td><td>15.1<sup>a</sup></td><td>100</td></tr><tr><td>Lepeule et al. [25]</td><td>756</td><td>81 + 42<sup>b</sup></td><td>N/A</td><td>73.3 ± 6.7</td><td>2.50 ± 0.6</td><td>N/A</td><td>20.5 ± 25.7</td><td>4</td><td>0</td></tr><tr><td>Lange et al. [26]</td><td>663</td><td>107</td><td>N/A</td><td>72.7 ± 6.7</td><td>2.70 ± 0.64</td><td>75 ± 8</td><td>30.6 ± 24.8</td><td>7</td><td>0</td></tr><tr><td>Marioni et al. [21]</td><td>1091</td><td>N/A</td><td>N/A</td><td>69.8 ± 0.78</td><td>2.36 ± 0.69</td><td>N/A</td><td>N/A</td><td>N/A</td><td>50.4</td></tr><tr><td>Wielscher et al. [24]</td><td>204</td><td>42</td><td>27 healthy +34 GOLD grade 0</td><td>53.4± 13.4<sup>c</sup></td><td>N/A</td><td>N/A</td><td>N/A</td><td>N/A</td><td>23.2<sup>d</sup></td></tr></table>
97a7d65a6abb51c51efce285d7a4a0e4ee2398eda538118b21dd831a39016ea6.png	simple	<table><tr><td>Cultivar</td><td>TDZ/BA concentration</td><td>No. of explants</td><td>% of explants producing massive shoots/buds<sup>x</sup>(mean ± standard error)</td></tr><tr><td>Accent Red</td><td>1 μM TDZ + 0 μM BA (IM1)</td><td>121</td><td>20.5 ± 6.4 A</td></tr><tr><td></td><td>2.3 μM TDZ + 1.8 μM BA (IM2)</td><td>121</td><td>66.5 ± 6.4 B</td></tr><tr><td></td><td>1 μM TDZ + 2.2 μM BA (IM3)</td><td>119</td><td>42.6 ± 6.4 C</td></tr><tr><td>Salmon</td><td>1 μM TDZ + 0 μM BA (IM1)</td><td>65</td><td>59.5 ± 5.3 A</td></tr><tr><td>Picote</td><td>2.3 μM TDZ + 1.8 μM BA (IM2)</td><td>68</td><td>80.1 ± 4.6 B</td></tr><tr><td></td><td>1 μM TDZ + 2.2 μM BA (IM3)</td><td>65</td><td>43.9 ± 5.3 A</td></tr></table>
1ad0520b05744b4ceeb9e047ce2bd3cf5fa7fb778b19b0be64944392cb258392.png	simple	<table><tr><td> </td><td> </td><td>F<sub>ST</sub></td><td>mAI<sub>C</sub></td><td>vAI<sub>C</sub></td><td>mPr</td></tr><tr><td>Clusters 3 & 4</td><td>F (202)</td><td>0.028</td><td>0.476</td><td>20.05</td><td>0.031</td></tr><tr><td> </td><td>M (179)</td><td>0.028</td><td>−0.537</td><td>17.20</td><td>0.033</td></tr><tr><td> </td><td><i>P-value</i></td><td>0.991</td><td>0.012</td><td>0.261</td><td>0.255</td></tr><tr><td>Cluster 2</td><td>F (71)</td><td>0.061</td><td>0.706</td><td>11.64</td><td>0.115</td></tr><tr><td> </td><td>M (52)</td><td>0.076</td><td>−0.964</td><td>22.15</td><td>0.137</td></tr><tr><td> </td><td><i>P-value</i></td><td>0.617</td><td>0.024</td><td>0.025</td><td>0.001</td></tr><tr><td>Cluster 1</td><td>F (61)</td><td>0.020</td><td>0.541</td><td>17.19</td><td>0.099</td></tr><tr><td> </td><td>M (44)</td><td>0.013</td><td>−0.750</td><td>35.52</td><td>0.252</td></tr><tr><td> </td><td><i>P-value</i></td><td>0.931</td><td>0.144</td><td>0.033</td><td>0.000</td></tr></table>
49b7f9085c970bf95d3a7c863ea3d36cae5788cda424b05c25d3a043a6a5965a.png	complex	<table><tr><td rowspan="2"></td><td colspan="6">SITE</td></tr><tr><td>NHA, <i>n</i> (%)</td><td>UATH, <i>n</i> (%)</td><td>MCHO, <i>n</i> (%)</td><td>GHA, <i>n</i> (%)</td><td>FMCK, <i>n</i> (%)</td><td>AKTH, <i>n</i> (%)</td></tr><tr><td>SCREENED, 5190</td><td>1979 (38.1)</td><td>1792 (34.5)</td><td>539 (10.4)</td><td>352 (6.8)</td><td>393 (7.6 %)</td><td>135 (2.6)</td></tr><tr><td> HIV Positive = 3212, <i>n</i> (%)</td><td>1563 (48.7)</td><td>1431 (44.6)</td><td>15 (0.4)</td><td>39 (1.2)</td><td>130 (4.0)</td><td>35 (1.1)</td></tr><tr><td> HIV Negative = 1978, <i>n</i> (%)</td><td>416 (21.0)</td><td>361 (18.3)</td><td>524 (26.5)</td><td>313 (15.8)</td><td>263 (13.3)</td><td>100 (5.1)</td></tr><tr><td>INCLUDED IN STUDY, 177</td><td>102 (57.6)</td><td>48 (27.1)</td><td>8 (4.5)</td><td>14 (8.0)</td><td>5 (2.8)</td><td>0 (0.0)</td></tr><tr><td> HIV Positive = 120, <i>n</i> (%)</td><td>79 (65.8)</td><td>38 (31.7)</td><td>1 (0.8)</td><td>2 (1.7)</td><td>0 (0.0)</td><td>0 (0.0)</td></tr><tr><td> HIV Negative = 57, <i>n</i> (%)</td><td>32 (40.3)</td><td>10 (18.5)</td><td>7 (12.3)</td><td>12 (21.1)</td><td>5 (8.8)</td><td>0 (0.0)</td></tr><tr><td>RECURRENCE, 29</td><td>13 (44.8)</td><td>13 (44.8)</td><td>1 (3.5)</td><td>2 (6.9)</td><td>0 (0.0)</td><td>0 (0.0)</td></tr><tr><td> HIV Positive = 22, <i>n</i> (%)</td><td>12 (54.5)</td><td>10 (45.5)</td><td>0 (0.0)</td><td>0 (0.0)</td><td>0 (0.0)</td><td>0 (0.0)</td></tr><tr><td> HIV Negative =7, <i>n</i> (%)</td><td>1 (14.3)</td><td>3 (42.8)</td><td>1 (14.3)</td><td>2 (28.6)</td><td>0 (0.0)</td><td>0 (0.0)</td></tr></table>
48be76e5efa5ccec4a6cd02e1cf0cca8ae608eb78cfbcb323699911155b90bbf.png	complex	<table><tr><td></td><td colspan="3">Men (N = 2389)</td><td colspan="3">Women (N = 2328)</td><td></td></tr><tr><td></td><td>n</td><td>%</td><td>%w</td><td>n</td><td>%</td><td>%w</td><td>p</td></tr><tr><td>Covariates in 2006</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Age (years)</td><td></td><td></td><td></td><td></td><td></td><td></td><td>ns</td></tr><tr><td><30</td><td>286</td><td>11.97</td><td>17.94</td><td>257</td><td>11.04</td><td>17.64</td><td></td></tr><tr><td>30-39</td><td>701</td><td>29.34</td><td>31.71</td><td>647</td><td>27.79</td><td>28.57</td><td></td></tr><tr><td>40-49</td><td>832</td><td>34.83</td><td>32.79</td><td>866</td><td>37.20</td><td>33.26</td><td></td></tr><tr><td>≥50</td><td>570</td><td>23.86</td><td>17.56</td><td>558</td><td>23.97</td><td>20.53</td><td></td></tr><tr><td>Occupation</td><td></td><td></td><td></td><td></td><td></td><td></td><td>**</td></tr><tr><td>Managers/professionals</td><td>401</td><td>16.80</td><td>16.66</td><td>318</td><td>13.67</td><td>11.86</td><td></td></tr><tr><td>Associate professionals/technicians</td><td>602</td><td>25.22</td><td>25.71</td><td>648</td><td>27.85</td><td>26.38</td><td></td></tr><tr><td>Clerks/service workers</td><td>327</td><td>13.70</td><td>17.30</td><td>1121</td><td>48.17</td><td>50.24</td><td></td></tr><tr><td>Manual workers</td><td>1057</td><td>44.28</td><td>40.13</td><td>240</td><td>10.31</td><td>11.53</td><td></td></tr><tr><td>Living alone</td><td>528</td><td>22.10</td><td>20.30</td><td>678</td><td>29.12</td><td>23.70</td><td></td></tr><tr><td>Presence of child(ren) under 3 y</td><td>289</td><td>12.10</td><td>14.88</td><td>200</td><td>8.59</td><td>10.67</td><td>**</td></tr><tr><td>Low social support outside work</td><td>626</td><td>26.20</td><td>26.43</td><td>739</td><td>31.74</td><td>29.81</td><td></td></tr><tr><td>Life events during childhood (one or more)</td><td>1077</td><td>45.08</td><td>45.80</td><td>1122</td><td>48.20</td><td>48.73</td><td>ns</td></tr><tr><td>Life events 2002–2006 (one or more)</td><td>207</td><td>8.67</td><td>8.49</td><td>252</td><td>10.83</td><td>10.76</td><td></td></tr><tr><td colspan="8">Occupational factors in 2006</td></tr><tr><td colspan="8">Psychosocial work factors</td></tr><tr><td>High psychological demands</td><td>998</td><td>41.77</td><td>41.80</td><td>840</td><td>36.08</td><td>35.66</td><td></td></tr><tr><td>Low decision latitude</td><td>780</td><td>32.65</td><td>35.15</td><td>728</td><td>31.27</td><td>32.49</td><td>ns</td></tr><tr><td>Low social support</td><td>565</td><td>23.65</td><td>23.95</td><td>506</td><td>21.74</td><td>21.93</td><td>ns</td></tr><tr><td>Low reward</td><td>716</td><td>29.97</td><td>31.12</td><td>732</td><td>31.44</td><td>31.64</td><td>ns</td></tr><tr><td>Emotional demands</td><td>740</td><td>30.98</td><td>33.43</td><td>1084</td><td>46.56</td><td>46.45</td><td></td></tr><tr><td>Role conflict</td><td>1084</td><td>45.37</td><td>46.86</td><td>1066</td><td>45.79</td><td>45.43</td><td>ns</td></tr><tr><td>Ethical conflict</td><td>857</td><td>35.87</td><td>35.92</td><td>654</td><td>28.09</td><td>27.86</td><td></td></tr><tr><td>Tensions with the public</td><td>959</td><td>40.14</td><td>41.83</td><td>1080</td><td>46.39</td><td>46.75</td><td></td></tr><tr><td>Job insecurity</td><td>520</td><td>21.77</td><td>22.22</td><td>468</td><td>20.10</td><td>21.10</td><td>ns</td></tr><tr><td>Work-life imbalance</td><td>750</td><td>31.39</td><td>32.64</td><td>693</td><td>29.77</td><td>29.83</td><td>ns</td></tr><tr><td>Working time/hours</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Long working hours</td><td>1008</td><td>42.19</td><td>42.41</td><td>523</td><td>22.47</td><td>21.94</td><td>*</td></tr><tr><td>Night work</td><td>595</td><td>24.91</td><td>25.77</td><td>230</td><td>9.88</td><td>10.44</td><td></td></tr><tr><td>Shift work</td><td>414</td><td>17.33</td><td>17.96</td><td>322</td><td>14.26</td><td>15.35</td><td></td></tr><tr><td>Low predictability</td><td>794</td><td>33.24</td><td>34.19</td><td>526</td><td>22.59</td><td>23.66</td><td>*</td></tr><tr><td>Physical work factors</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Biomechanical exposure</td><td>1040</td><td>45.53</td><td>42.89</td><td>718</td><td>30.84</td><td>32.38</td><td></td></tr><tr><td>Physical exposure</td><td>1242</td><td>51.99</td><td>49.63</td><td>597</td><td>25.64</td><td>26.33</td><td></td></tr><tr><td>Chemical exposure</td><td>1104</td><td>46.21</td><td>44.07</td><td>579</td><td>24.87</td><td>26.56</td><td></td></tr><tr><td>Mental disorders in 2010</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>MDD</td><td>61</td><td>2.55</td><td>2.53</td><td>114</td><td>4.90</td><td>4.75</td><td></td></tr><tr><td>GAD</td><td>66</td><td>2.76</td><td>2.81</td><td>120</td><td>5.15</td><td>4.58</td><td></td></tr></table>
8bdaffaecb19c02d7faef5e2ae3a535af7a14c31ef0260bfeb06bd2fb0c26563.png	complex	<table><tr><td>The Value of <i>L</i> (mm)</td><td>Strength of the Alternating Magnetic Field (A/m)</td><td>Compensation Ratio of <i>V<sub>pp</sub></i></td><td colspan="2"><i>f<sub>L</sub></i> (kHz)</td><td colspan="2"><i>f</i><i><sub>n</sub></i>(kHz)</td><td colspan="2">Relative Tolerance</td></tr><tr><td>20</td><td>6892</td><td colspan="2">1.11</td><td colspan="2">-</td><td colspan="2">172</td><td colspan="2">-</td></tr><tr><td>25</td><td>7299</td><td colspan="2">1.05</td><td colspan="2">160</td><td colspan="2">138</td><td colspan="2">13.7%</td></tr><tr><td>30</td><td>7499</td><td colspan="2">1.02</td><td colspan="2">140</td><td colspan="2">115</td><td colspan="2">17.8%</td></tr><tr><td>40</td><td>7651</td><td colspan="2">1</td><td colspan="2">100</td><td colspan="2">86</td><td colspan="2">14%</td></tr></table>
d9dbf69915ef697e34fc592bc0557be3eb8b2abeccd8ba07cdc6535239a30293.png	complex	<table><tr><td colspan="2"></td><td>IM</td><td>GS</td><td>OBGY</td><td>Ped</td><td>Psy</td><td>OS</td><td>EM</td><td>Total</td></tr><tr><td>History Taking</td><td>Min</td><td>2</td><td>0</td><td>0</td><td>1</td><td>1</td><td>0</td><td>0</td><td>5</td></tr><tr><td></td><td>Max</td><td>30</td><td>30</td><td>10</td><td>16</td><td>20</td><td>10</td><td>10</td><td>85</td></tr><tr><td></td><td>Mean</td><td>13.9</td><td>8.6</td><td>3.1</td><td>4.9</td><td>5.7</td><td>1.9</td><td>2.6</td><td>40.5</td></tr><tr><td></td><td>SD</td><td>5.5</td><td>5.5</td><td>2.7</td><td>2.7</td><td>3.0</td><td>2.0</td><td>1.7</td><td>14.9</td></tr><tr><td>Physical Exam</td><td>Min</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td></tr><tr><td></td><td>Max</td><td>30</td><td>20</td><td>10</td><td>16</td><td>12</td><td>20</td><td>10</td><td>85</td></tr><tr><td></td><td>Mean</td><td>12.9</td><td>7.9</td><td>2.5</td><td>4.5</td><td>3.6</td><td>1.7</td><td>2.3</td><td>35.4</td></tr><tr><td></td><td>SD</td><td>5.4</td><td>5.2</td><td>2.6</td><td>2.7</td><td>3.4</td><td>2.3</td><td>1.6</td><td>14.3</td></tr></table>
a1d5ce78771b1d2359ac5e01c8f1d1f7e519cc2f9b7f7260d26efef1ad2421cf.png	simple	<table><tr><td>Manner of intent <sup>a,b</sup></td><td>Total N (%)</td><td>Mean</td><td>Std. Dev.</td><td>Min</td><td>Max</td></tr><tr><td>Total firearm deaths</td><td>5,660 (100)</td><td>138.1</td><td>43.5</td><td>67</td><td>243</td></tr><tr><td> Accidental</td><td>164 (2.9)</td><td>4</td><td>3.2</td><td>-</td><td>11</td></tr><tr><td> Suicide <sup>a</sup></td><td>5,025 (88.8)</td><td>122.6</td><td>40</td><td>57</td><td>212</td></tr><tr><td> Homicide <sup>a</sup></td><td>432 (7.6)</td><td>10.5</td><td>4.7</td><td>2</td><td>24</td></tr><tr><td> Event of undetermined intent <sup>a</sup></td><td>34 (0.6)</td><td>0.8</td><td>0.9</td><td>-</td><td>3</td></tr><tr><td> Legal investigation.</td><td>- (-)</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td> Operation of war <sup>c</sup></td><td>5 (0.1)</td><td>0.1</td><td>0.3</td><td>-</td><td>1</td></tr><tr><td>MALE</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Total firearm deaths</td><td>5,334 (100)</td><td>130.1</td><td>40.2</td><td>64</td><td>221</td></tr><tr><td> Accidental</td><td>158 (3.0)</td><td>3.9</td><td>3.1</td><td>-</td><td>11</td></tr><tr><td> Suicide <sup>a</sup></td><td>4,863 (91.2)</td><td>118.6</td><td>37.9</td><td>54</td><td>199</td></tr><tr><td> Homicide <sup>a</sup></td><td>276 (5,2)</td><td>6.7</td><td>3.6</td><td>1</td><td>15</td></tr><tr><td> Event of undetermined intent <sup>a</sup></td><td>32 (0.6)</td><td>0.8</td><td>0.9</td><td>-</td><td>3</td></tr><tr><td> Legal investigation</td><td>- (-)</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td> Operation of war <sup>c</sup></td><td>5 (0.1)</td><td>0.1</td><td>0.3</td><td>-</td><td>1</td></tr><tr><td>FEMALE</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Total firearm deaths</td><td>326 (100)</td><td>8</td><td>4.1</td><td>1</td><td>22</td></tr><tr><td> Accidental</td><td>6 (1.8)</td><td>0.2</td><td>0.4</td><td>-</td><td>1</td></tr><tr><td> Suicide <sup>a</sup></td><td>162 (49.7)</td><td>4</td><td>2.7</td><td>-</td><td>13</td></tr><tr><td> Homicide <sup>a</sup></td><td>156 (47.9)</td><td>3.8</td><td>2.3</td><td>-</td><td>10</td></tr><tr><td> Event of undetermined intent <sup>a</sup></td><td>2 (0.6)</td><td>0.1</td><td>0.2</td><td>-</td><td>1</td></tr><tr><td> Legal investigation</td><td>- (-)</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td> Operation of war <sup>c</sup></td><td>- (-)</td><td>-</td><td>-</td><td>-</td><td>-</td></tr></table>
66f209bae12e4f11c90b7e1ec94d93a2bb8f5a97c4ca58703dfea58186f9247a.png	simple	<table><tr><td></td><td>Dapagliflozin N = 10 227</td><td>DPP‐4 inhibitor N = 30 681</td><td>Standardized differencea</td></tr><tr><td>Age, years (s.d.)</td><td>61 (11.1)</td><td>60.8 (12.4)</td><td>0.017</td></tr><tr><td>Sex (Female)</td><td>4196 (41.0)</td><td>12 391 (40.4)</td><td>0.011</td></tr><tr><td>First GLD, years (s.d.)</td><td>6.5 (4.1)</td><td>6.5 (4.1)</td><td>0.009</td></tr><tr><td>CV disease</td><td>2356 (23.0)</td><td>6970 (22.7)</td><td>0.006</td></tr><tr><td>Myocardial infarction</td><td>730 (7.1)</td><td>2183 (7.1)</td><td>0.001</td></tr><tr><td>Stroke</td><td>566 (5.5)</td><td>1699 (5.5)</td><td>0.000</td></tr><tr><td>Unstable angina</td><td>286 (2.8)</td><td>900 (2.9)</td><td>0.007</td></tr><tr><td>Heart failure</td><td>485 (4.7)</td><td>1440 (4.7)</td><td>0.002</td></tr><tr><td>Atrial fibrillation</td><td>879 (8.6)</td><td>2549 (8.3)</td><td>0.008</td></tr><tr><td>Chronic kidney disease</td><td>219 (2.1)</td><td>626 (2.0)</td><td>0.006</td></tr><tr><td>Microvascular complications</td><td>1497 (14.6)</td><td>4449 (14.5)</td><td>0.003</td></tr><tr><td>Cancer</td><td>850 (8.3)</td><td>2624 (8.6)</td><td>0.007</td></tr><tr><td>Metformin</td><td>8522 (83.3)</td><td>25 705 (83.8)</td><td>0.010</td></tr><tr><td>Sulphonylurea</td><td>2668 (26.1)</td><td>7920 (25.8)</td><td>0.005</td></tr><tr><td>GLP‐1RAs</td><td>798 (7.8)</td><td>2309 (7.5)</td><td>0.008</td></tr><tr><td>Thiazolidinediones</td><td>148 (1.4)</td><td>416 (1.4)</td><td>0.006</td></tr><tr><td>Insulin</td><td>3105 (30.4)</td><td>8920 (29.1)</td><td>0.023</td></tr><tr><td>Short‐acting</td><td>1124 (11.0)</td><td>3307 (10.8)</td><td>0.006</td></tr><tr><td>Intermediate‐acting</td><td>1504 (14.7)</td><td>4358 (14.2)</td><td>0.012</td></tr><tr><td>Premixed insulin</td><td>813 (7.9)</td><td>2350 (7.7)</td><td>0.009</td></tr><tr><td>Long‐acting</td><td>1044 (10.2)</td><td>3062 (10.0)</td><td>0.006</td></tr><tr><td>CV disease preventive drugs</td><td>8702 (85.1)</td><td>26 041 (84.9)</td><td>0.005</td></tr><tr><td>Low‐dose aspirin</td><td>3497 (34.2)</td><td>10 434 (34.0)</td><td>0.003</td></tr><tr><td>Statins</td><td>6457 (63.1)</td><td>19 405 (63.2)</td><td>0.002</td></tr><tr><td>Antihypertensives</td><td>7483 (73.2)</td><td>22 255 (72.5)</td><td>0.012</td></tr><tr><td>Loop diuretics</td><td>1364 (13.3)</td><td>4036 (13.2)</td><td>0.004</td></tr><tr><td>Aldosteron antagonists</td><td>441 (4.3)</td><td>1303 (4.2)</td><td>0.003</td></tr><tr><td>Warfarin</td><td>527 (5.2)</td><td>1530 (5.0)</td><td>0.006</td></tr><tr><td>Receptor P2Y12 antagonists</td><td>471 (4.6)</td><td>1351 (4.4)</td><td>0.008</td></tr></table>
99018e18a6f6327763b224f2a88c5d0a5d38ad38879a22c3de7cd37b0d33f0ef.png	complex	<table><tr><td rowspan="2">Variable</td><td>Premetformin</td><td>Postmetformin</td><td>Change</td><td><i>P</i>-value</td></tr><tr><td>Median (Q1, Q3)</td><td>Median (Q1, Q3)</td><td>Median (Q1, Q3)</td><td></td></tr><tr><td>Insulin receptor</td><td>4.5 (3, 6)</td><td>4 (2, 5)</td><td>0 (−1, 0)</td><td>0.0375</td></tr><tr><td>OCT1</td><td>ND</td><td>7 (6, 7)</td><td>ND</td><td>ND</td></tr><tr><td>Cytoplasmic p-Akt (S473)</td><td>6 (5.5, 7)</td><td>3 (3, 5)</td><td>−2 (−3, −1)</td><td><0.0001</td></tr><tr><td>Nuclear p-Akt (S473)</td><td>4 (2, 5.5)</td><td>3 (2, 4.5)</td><td>0 (−2, 1)</td><td>0.206</td></tr><tr><td>Overall p-Akt (S473)</td><td>5 (4, 6)</td><td>3.5 (2.5, 4.5)</td><td>−1.5 (−2.5, −0.2)</td><td>0.0001</td></tr><tr><td>p-ERK (T202/Y204)</td><td>7 (6, 7)</td><td>4 (3, 6)</td><td>−2 (−4, 0)</td><td><0.0001</td></tr><tr><td>p-AMPK (T172)</td><td>7 (5.2, 7)</td><td>5 (4, 6)</td><td>−1.5 (−3, 0)</td><td>0.0034</td></tr><tr><td>p-ACC (S79)</td><td>5 (4, 6)</td><td>4 (3, 5)</td><td>−1 (−2, 1)</td><td>0.0193</td></tr></table>
bd87ed45405da0250964a37cdf3dc8c7165e6d54e370931122de5ba6137e5155.png	simple	<table><tr><td>Gene Description</td><td>Unigene</td><td>Gene Bank</td><td>Function</td></tr><tr><td>Cadherin 5, type 2, VE-cadherin</td><td>Hs.76206</td><td>NM_001795</td><td>Plays an important role in cell adhesion and is crucial for vessel growth and maturation.</td></tr><tr><td>Collagen, type XVIII, alpha 1</td><td>Hs.517356</td><td>NM_030582</td><td>Component of extra-cellular matrix (ECM) that is important for tissue organization.</td></tr><tr><td>Collagen, type IV, alpha 3</td><td>Hs.570065</td><td>NM_000091</td><td></td></tr><tr><td>Integrin, alpha V</td><td>Hs.436873</td><td>NM_002210</td><td>Cell adhesion molecules that plays a key role in tumor growth, angiogenesis and metastasis.</td></tr><tr><td>Integrin, beta 3</td><td>Hs.218040</td><td>NM_000212</td><td></td></tr><tr><td>Hepatocyte growth factor</td><td>Hs.396530</td><td>NM_000601</td><td>Stimulates tumor cell motility, invasion and angiogenesis and its receptor is a tyrosine kinase encoded by c-met.</td></tr><tr><td>Ephrin-A3</td><td>Hs.516656</td><td>NM_004952</td><td>Ephrins are cell-membrane-bound ligands for Eph receptor tyrosine kinases and regulate a variety of developmental processes.</td></tr><tr><td>Platelet-derived growth factor alpha polypeptide</td><td>Hs.645488</td><td>NM_002607</td><td>Stimulates endothelial cell proliferation.</td></tr><tr><td>Epidermal growth factor</td><td>Hs.419815</td><td>NM_001963</td><td>An EGFR ligand, regulates cell growth, proliferation and differentiation.</td></tr><tr><td>Neuropilin 2</td><td>Hs.471200</td><td>NM_003872</td><td>Receptor for VEGF and semaphorin (SEMA) and is involved in angiogenesis and neuronal guidance.</td></tr><tr><td>Ephrin-B2</td><td>Hs.149239</td><td>NM_004093</td><td>An Eph ligand, promotes cell attachment, cell-adhesion, migration, capillary tube formation and tumor angiogenesis.</td></tr><tr><td>Jagged 1</td><td>Hs.224012</td><td>NM_000214</td><td>A notch ligand, it regulates a transmembrane ligand-receptor signaling pathway involved in the regulation of endothelial cell differentiation.</td></tr><tr><td>Tumor necrosis factor, alpha-induced protein 2</td><td>Hs.525607</td><td>NM_006291</td><td>A cytokine mainly produced by macrophages causes apoptotic cell death, cellular proliferation, differentiation and inflammation.</td></tr><tr><td>TEK tyrosine kinase, endothelial</td><td>Hs.89640</td><td>NM_000459</td><td>Helps in vascular maturation, maintenance of integrity and remodeling.</td></tr><tr><td>Transforming growth factor, alpha</td><td>Hs.170009</td><td>NM_003236</td><td>Binds to EGFR and is involved in tumorigenesis.</td></tr><tr><td>Vascular endothelial growth factor C</td><td>Hs.435215</td><td>NM_005429</td><td>Involved in angiogenesis and lymphangiogenesis.</td></tr></table>
d50f41df039fe9943a4c5b402af89f7261b3a4ca020f515b346461ac5225a7aa.png	simple	<table><tr><td>Original data</td><td>Secret data</td><td>XOR result</td></tr><tr><td>0</td><td>0</td><td>0</td></tr><tr><td>0</td><td>1</td><td>1</td></tr><tr><td>1</td><td>0</td><td>1</td></tr><tr><td>1</td><td>1</td><td>0</td></tr></table>

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