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a1bd3894c345647d6390e52e2d6c158e93e9f17b88f02185969233b82c8b3f3f.png
complex
<table><tr><td rowspan="2">Treatments</td><td colspan="5">Reaction time in seconds (mean &#177; SEM)</td></tr><tr><td>0 min</td><td>15 min</td><td>30 min</td><td>45 min</td><td>60 min</td></tr><tr><td>Control (normal saline)</td><td>4.25 &#177; 0.57</td><td>4.50 &#177; 0.34</td><td>4.42 &#177; 0.45</td><td>4.58 &#177; 0.44</td><td>5.17 &#177; 0.80</td></tr><tr><td>Morphine sulfate</td><td>6.50 &#177; 1.22</td><td>11.04 &#177; 0.73<sup>&#8727;ab</sup></td><td>11.92 &#177; 0.84<sup>&#8727;ab</sup></td><td>12.83 &#177; 0.35<sup>&#8727;ab</sup></td><td>13.33 &#177; 0.83<sup>&#8727;ab</sup></td></tr><tr><td>Sodium salicylate</td><td>4.13 &#177; 0.54</td><td>5.29 &#177; 0.57</td><td>6.75 &#177; 0.62<sup>&#8727;a</sup></td><td>5.75 &#177; 0.56</td><td>6.79 &#177; 1.24</td></tr><tr><td><i>Quercus infectoria </i>(galls) extract</td><td>6.67 &#177; 0.85<sup>a</sup></td><td>7.04 &#177; 0.67<sup>a</sup></td><td>8.04 &#177; 0.73<sup>a</sup></td><td>7.00 &#177; 0.92<sup>a</sup></td><td>6.67 &#177; 0.86</td></tr></table>
e8e66370c8360d5b0800198160ed4bb16136ba6dd9069285639e1e342ddc3076.png
complex
<table><tr><td>Items_Details</td><td>Number of genes</td><td>Adjusted <i>p</i>-Value<sup>a</sup></td><td>Genes</td></tr><tr><td colspan="4">Signaling pathways</td></tr><tr><td>Focal adhesion</td><td>27</td><td>1.8E-08</td><td><i>ITGA1</i>, <i>MAPK1</i>, <i>comP</i>, <i>ITGA6</i>, <i>ERBB2</i>, <i>LAMA2</i>, <i>CCND2</i>, <i>BCAR1</i>, <i>DIAPH1</i>, <i>PTEN</i>, <i>ITGA2</i>, <i>SPP1</i>, <i>ACTB</i>, <i>LAMC1</i>, <i>CAPN2</i>, <i>COL4A1</i>, <i>EGFR</i>, <i>VAV2</i>, <i>THBS4</i>, <i>ITGA9</i>, <i>THBS2</i>, <i>PTK2</i>, <i>PIK3CG</i>, <i>VEGFA</i>, <i>fn1</i>, <i>PPP1CB</i>, <i>VAV3</i></td></tr><tr><td>Regulation of actin cytoskeleton</td><td>27</td><td>3.5E-08</td><td><i>PIP4K2A</i>, <i>ITGA1</i>, <i>MAPK1</i>, <i>ARPC2</i>, <i>ITGA6</i>, <i>ITGB2</i>, <i>ARPC1B</i>, <i>F2R</i>, <i>BCAR1</i>, <i>DIAPH1</i>, <i>GNA12</i>, <i>ITGA2</i>, <i>NCKAP1L</i>, <i>GSN</i>, <i>ACTB</i>, <i>TMSB4X</i>, <i>EGFR</i>, <i>VAV2</i>, <i>ITGA9</i>, <i>CD14</i>, <i>PTK2</i>, <i>Kras</i>, <i>BAIAP2</i>, <i>PIK3CG</i>, <i>fn1</i>, <i>PPP1CB</i>, <i>VAV3</i></td></tr><tr><td>ECM-receptor interaction</td><td>14</td><td>5.8E-06</td><td><i>ITGA1</i>, <i>comP</i>, <i>ITGA6</i>, <i>LAMA2</i>, <i>ITGA2</i>, <i>GP1BB</i>, <i>SPP1</i>, <i>LAMC1</i>, <i>COL4A1</i>, <i>THBS4</i>, <i>ITGA9</i>, <i>THBS2</i>, <i>AGRN</i>, <i>fn1</i></td></tr><tr><td>Adherens junction</td><td>12</td><td>2.7E-05</td><td><i>MAPK1</i>, <i>PARD3</i>, <i>CTNNA3</i>, <i>ACP1</i>, <i>ERBB2</i>, <i>PTPRJ</i>, <i>ACTB</i>, <i>EGFR</i>, <i>BAIAP2</i>, <i>CREBBP</i>, <i>SORBS1</i>, <i>PVRL3</i></td></tr><tr><td colspan="4">Metabolic pathways</td></tr><tr><td>Valine, leucine and isoleucine degradation</td><td>12</td><td>2.3E-07</td><td><i>ALDH3A2</i>, <i>BCAT1</i>, <i>OXCT1</i>, <i>EHHADH</i>, <i>IVD</i>, <i>BCKDHB</i>, <i>ECHS1</i>, <i>ACADSB</i>, <i>HADHA</i>, <i>PCCB</i>, <i>AUH</i>, <i>ALDH2</i></td></tr><tr><td>Lysine degradation</td><td>9</td><td>0.0002</td><td><i>MLL5</i>, <i>ALDH3A2</i>, <i>EHHADH</i>, <i>NSD1</i>, <i>WHSC1L1</i>, <i>ECHS1</i>, <i>HADHA</i>, <i>setmar</i>, <i>ALDH2</i></td></tr><tr><td>Purine metabolism</td><td>16</td><td>0.00033</td><td><i>NUDT2</i>, <i>Pgm2</i>, <i>GMPR2</i>, <i>POLR2G</i>, <i>ENPP1</i>, <i>RRM2B</i>, <i>FHIT</i>, <i>GUCY1A3</i>, <i>ADA</i>, <i>NT5C2</i>, <i>NME6</i>, <i>PGM1</i>, <i>PRPS2</i>, <i>ATIC</i>, <i>NT5E</i>, <i>POLR3E</i></td></tr><tr><td>beta-Alanine metabolism</td><td>6</td><td>0.00088</td><td><i>ALDH3A2</i>, <i>EHHADH</i>, <i>ECHS1</i>, <i>CARNS1</i>, <i>HADHA</i>, <i>ALDH2</i></td></tr><tr><td>Arginine and proline metabolism</td><td>8</td><td>0.0014</td><td><i>ALDH3A2</i>, <i>ACY1</i>, <i>P4HA1</i>, <i>GLUD1</i>, <i>CARNS1</i>, <i>AMD1</i>, <i>ALDH4A1</i>, <i>ALDH2</i></td></tr><tr><td>Fatty acid metabolism</td><td>7</td><td>0.0014</td><td><i>ALDH3A2</i>, <i>EHHADH</i>, <i>ECHS1</i>, <i>ACADSB</i>, <i>ACSL4</i>, <i>HADHA</i>, <i>ALDH2</i></td></tr><tr><td colspan="4">Cellular processes</td></tr><tr><td>Phagosome</td><td>21</td><td>9.2E-08</td><td><i>comP</i>, <i>CTSS</i>, <i>ATP6V1C1</i>, <i>ITGB2</i>, <i>ITGA2</i>, <i>PIK3C3</i>, <i>ACTB</i>, <i>CYBB</i>, <i>CYBA</i>, <i>TFRC</i>, <i>THBS4</i>, <i>CD14</i>, <i>THBS2</i>, <i>NCF4</i>, <i>NCF2</i>, <i>DYNC1I2</i>, <i>EEA1</i>, <i>FCGR2B</i>, <i>MRC1</i>, <i>TUBA8</i>, <i>TUBA4A</i></td></tr><tr><td>Protein processing in endoplasmic reticulum</td><td>21</td><td>7E-07</td><td><i>nsfl1c</i>, <i>BAG2</i>, <i>UBE4B</i>, <i>PARK2</i>, <i>SAR1B</i>, <i>HSPH1</i>, <i>SEC24D</i>, <i>DNAJC1</i>, <i>CAPN2</i>, <i>DDOST</i>, <i>BCAP31</i>, <i>HSPA2</i>, <i>PDIA3</i>, <i>CUL1</i>, <i>UBE2D4</i>, <i>HERPUD1</i>, <i>EDEM2</i>, <i>DNAJA1</i>, <i>DERL1</i>, <i>CKAP4</i>, <i>TUSC3</i></td></tr><tr><td>mRNA surveillance pathway</td><td>13</td><td>0.000016</td><td><i>SAP18</i>, <i>PPP2R5A</i>, <i>CPSF6</i>, <i>CLP1</i>, <i>PPP2R2A</i>, <i>PAPOLA</i>, <i>PAPOLB</i>, <i>PPP2CB</i>, <i>Fip1l1</i>, <i>ETF1</i>, <i>HBS1L</i>, <i>CPSF3</i>, <i>CSTF2T</i></td></tr><tr><td>Endocytosis</td><td>20</td><td>3.61E-05</td><td><i>RAB11FIP5</i>, <i>PARD3</i>, <i>KIT</i>, <i>F2R</i>, <i>DNM2</i>, <i>EHD1</i>, <i>RABEP1</i>, <i>ARRB2</i>, <i>GRK5</i>, <i>DNM1L</i>, <i>FOLR1</i>, <i>EGFR</i>, <i>TFRC</i>, <i>HSPA2</i>, <i>WWP1</i>, <i>ZFYVE16</i>, <i>SMAP2</i>, <i>EEA1</i>, <i>epn1</i>, <i>FAM125B</i></td></tr></table>
2245b0ebc2ede644d143c5883dd7819ccffafa6ce92f108e1bc57dd8c4160fa9.png
simple
<table><tr><td></td><td></td><td><i>N</i></td><td>Zinc concentration</td><td><i>N</i></td><td>Height for age z score (mean &#177; sd)</td></tr><tr><td>Cuba</td><td>STH uninfected</td><td>160</td><td>112.55 (88.3&#8211;136.0) <sup>a</sup></td><td>1251</td><td>0.11 &#177; 0.97</td></tr><tr><td></td><td>STH infected</td><td>70</td><td>113.35 (94.4&#8211;143.7) <sup>a</sup></td><td>117</td><td>&#8722;0.31 &#177; 1.16</td></tr><tr><td>Cambodia</td><td>STH uninfected</td><td>1239</td><td>7.74 &#177; 1.70 <sup>b</sup></td><td>1450</td><td>&#8722;1.81 &#177; 1.05</td></tr><tr><td></td><td>STH infected</td><td>254</td><td>7.52 &#177; 1.70 <sup>b</sup></td><td>296</td><td>&#8722;1.84 &#177; 1.09</td></tr></table>
056421e40e94adfb3eb1f6ed9c676cfeb9eb5a35c2488024b08bb41687464cf8.png
simple
<table><tr><td>NPI domains</td><td>FxS ICC (95% CI)</td><td>Distress ICC (95% CI)</td></tr><tr><td>Delusions</td><td>0.936 (0.860, 0.971)</td><td>0.958 (0.908, 0.981)</td></tr><tr><td>Hallucinations</td><td>0.897 (0.780, 0.953)</td><td>0.882 (0.750, 0.946)</td></tr><tr><td>Agitation/aggression</td><td>0.799 (0.596, 0.906)</td><td>0.818 (0.630, 0.916)</td></tr><tr><td>Depression/dysphoria</td><td>0.728 (0.473, 0.870)</td><td>0.699 (0.427, 0.855)</td></tr><tr><td>Anxiety</td><td>0.670 (0.381, 0.840)</td><td>0.508 (0.149, 0.749)</td></tr><tr><td>Elation/euphoria</td><td>0.600 (0.276, 0.802)</td><td>0.923 (0.834, 0.965)</td></tr><tr><td>Apathy/indifference</td><td>0.691 (0.415, 0.851)</td><td>0.621 (0.307, 0.813)</td></tr><tr><td>Disinhibition</td><td>0.296 (-0.104, 0.614)</td><td>0.531 (0.179, 0.762)</td></tr><tr><td>Irritability/lability</td><td>0.524 (0.170, 0.758)</td><td>0.542 (0.195, 0.768)</td></tr><tr><td>Aberrant motor behavior</td><td>0.976 (0.946, 0.989)</td><td>1.000 (1.000, 1.000)</td></tr><tr><td>Total</td><td>0.909 (0.804, 0.959)</td><td>0.890 (0.766, 0.950)</td></tr><tr><td>Sleep/nighttime behavior disorders</td><td>0.650 (0.350, 0.829)</td><td>0.741 (0.496, 0.877)</td></tr><tr><td>Appetite and eating changes</td><td>0.607 (0.286, 0.805)</td><td>0.648 (0.347, 0.828)</td></tr></table>
6d8f00d1111a5d1b2a6ec2bed57cd4bc5bf3744b01cbdd4c64fb37ebb785c17c.png
complex
<table><tr><td rowspan="2">Toxin</td><td colspan="2">Mussels</td><td colspan="2">Clams</td><td colspan="2">Scallops</td><td colspan="2">Oysters</td></tr><tr><td>LOD</td><td>LOQ</td><td>LOD</td><td>LOQ</td><td>LOD</td><td>LOQ</td><td>LOD</td><td>LOQ</td></tr><tr><td>GTX4</td><td>0.0183</td><td>0.0549</td><td>0.0201</td><td>0.0603</td><td>0.0221</td><td>0.0663</td><td>0.048</td><td>0.144</td></tr><tr><td>GTX1</td><td>0.0642</td><td>0.1926</td><td>0.0320</td><td>0.0960</td><td>0.0488</td><td>0.1464</td><td>0.057</td><td>0.171</td></tr><tr><td>dcGTX3</td><td>0.0071</td><td>0.0213</td><td>0.0096</td><td>0.0288</td><td>0.0097</td><td>0.0291</td><td>0.003</td><td>0.009</td></tr><tr><td>GTX5</td><td>0.0011</td><td>0.0033</td><td>0.0088</td><td>0.0264</td><td>0.0298</td><td>0.0894</td><td>0.025</td><td>0.075</td></tr><tr><td>dcGTX2</td><td>0.0210</td><td>0.0630</td><td>0.0181</td><td>0.0543</td><td>0.0244</td><td>0.0732</td><td>0.030</td><td>0.090</td></tr><tr><td>GTX3</td><td>0.0055</td><td>0.0165</td><td>0.0072</td><td>0.0216</td><td>0.0073</td><td>0.0219</td><td>0.011</td><td>0.033</td></tr><tr><td>GTX2</td><td>0.0099</td><td>0.0297</td><td>0.0306</td><td>0.0918</td><td>0.0199</td><td>0.0597</td><td>0.023</td><td>0.069</td></tr><tr><td>NEO</td><td>0.0239</td><td>0.0717</td><td>0.0329</td><td>0.0987</td><td>0.0375</td><td>0.1125</td><td>0.018</td><td>0.054</td></tr><tr><td>dcSTX</td><td>0.0047</td><td>0.0141</td><td>0.0172</td><td>0.0516</td><td>0.0074</td><td>0.0222</td><td>0.0005</td><td>0.001</td></tr><tr><td>STX</td><td>0.0100</td><td>0.0300</td><td>0.0394</td><td>0.1182</td><td>0.0111</td><td>0.0333</td><td>0.009</td><td>0.027</td></tr><tr><td>C1</td><td>0.0001</td><td>0.0003</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>C2</td><td>0.0011</td><td>0.0033</td><td></td><td></td><td></td><td></td><td></td><td></td></tr></table>
f7974ad84e54f536e3ced5554f744149a2a0bbbfce4b45f3dde7e828f2fb50c7.png
simple
<table><tr><td>Trait</td><td>Rep</td><td>Block(Rep)</td><td>Variety</td><td>h2</td></tr><tr><td>LLGHT</td><td>&lt;0.001</td><td>&lt; 0.001</td><td>&lt; 0.001</td><td>0.90</td></tr><tr><td>TIL</td><td>&lt; 0.001</td><td>0.0009</td><td>&lt; 0.001</td><td>0.80</td></tr><tr><td>SDW</td><td>0.0043</td><td>&lt; 0.0001</td><td>&lt; 0.0001</td><td>0.73</td></tr><tr><td>DEPTH</td><td>0.0254</td><td>0.0003</td><td>0.0002</td><td>0.35</td></tr><tr><td>MRL</td><td>0.1428</td><td>0.0277</td><td>0.0001</td><td>0.46</td></tr><tr><td>NCR</td><td>0.2270</td><td>&lt; 0.0001</td><td>&lt; 0.0001</td><td>0.84</td></tr><tr><td>NR_T</td><td>&lt;0.001</td><td>0.3450</td><td>&lt; 0.0001</td><td>0.72</td></tr><tr><td>THK</td><td>0.0071</td><td>0.0017</td><td>&lt; 0.0001</td><td>0.84</td></tr><tr><td>DW0020</td><td>0.0546</td><td>&lt; 0.0001</td><td>&lt; 0.0001</td><td>0.74</td></tr><tr><td>DW2040</td><td>0.1605</td><td>&lt; 0.0001</td><td>&lt; 0.0001</td><td>0.68</td></tr><tr><td>DW4060</td><td>0.4307</td><td>&lt; 0.001</td><td>&lt; 0.0001</td><td>0.69</td></tr><tr><td>DWB60</td><td>0.0260</td><td>0.0047</td><td>&lt; 0.0001</td><td>0.70</td></tr><tr><td>DRW</td><td>0.0863</td><td>0.0004</td><td>&lt; 0.0001</td><td>0.75</td></tr><tr><td>RDW</td><td>0.0650</td><td>&lt; 0.0001</td><td>&lt; 0.0001</td><td>0.75</td></tr><tr><td>PDW</td><td>0.0364</td><td>&lt; 0.0001</td><td>&lt; 0.0001</td><td>0.73</td></tr><tr><td>SRP</td><td>0.0207</td><td>0.0002</td><td>&lt; 0.0001</td><td>0.72</td></tr><tr><td>DRP</td><td>0.0179</td><td>0.0045</td><td>&lt; 0.0001</td><td>0.65</td></tr><tr><td>R_S</td><td>&lt; 0.0001</td><td>&lt; 0.0001</td><td>&lt; 0.0001</td><td>0.75</td></tr></table>
9cdf519315f1751383a81b149f4da634eed40b8ea8fef7cbdb53ddbf0d2ea91b.png
simple
<table><tr><td>Unit</td><td>LUTs</td><td>BRAM</td><td>SLICES</td><td>MULT18&#215;18</td></tr><tr><td>uF</td><td>908</td><td>0</td><td>615</td><td>4</td></tr><tr><td>uIS</td><td>1,115</td><td>1</td><td>870</td><td>2</td></tr><tr><td>PLC</td><td>2,636</td><td>2</td><td>1,410</td><td>0</td></tr><tr><td>ioP</td><td>24</td><td>0</td><td>15</td><td>0</td></tr><tr><td>System manager</td><td>213</td><td>0</td><td>117</td><td>0</td></tr><tr><td>CP</td><td>1,105</td><td>0</td><td>788</td><td>0</td></tr><tr><td>Total</td><td>6,001</td><td>3</td><td>3,815</td><td>6</td></tr><tr><td>Available</td><td>14,752</td><td>36</td><td>29,504</td><td>36</td></tr></table>
642c8afad06582b9e82997fa3e936016455e9560c4023d353b6e2f3881c0d8bd.png
complex
<table><tr><td>Covariate</td><td>Hazard ratio</td><td>95% CI</td><td><i>P</i>-value</td></tr><tr><td colspan="2">LBC1936 (<i>n</i> = 920, <i>n</i><sub>events</sub> = 135)</td><td></td><td></td></tr><tr><td> Age (years)</td><td>1.05</td><td>[0.85, 1.30]</td><td>0.65</td></tr><tr><td> Sex (female)</td><td>0.66</td><td>[0.46, 0.95]</td><td>0.025</td></tr><tr><td> Telomere length</td><td>0.95</td><td>[0.80, 1.13]</td><td>0.56</td></tr><tr><td> Hannum age</td><td>1.12</td><td>[0.94, 1.33]</td><td>0.21</td></tr><tr><td colspan="3">LBC1921 (<i>n</i> = 414, <i>n</i><sub>events</sub> = 280)</td><td></td></tr><tr><td> Age (years)</td><td>0.98</td><td>[0.79, 1.22]</td><td>0.86</td></tr><tr><td> Sex (female)</td><td>0.89</td><td>[0.69, 1.15]</td><td>0.37</td></tr><tr><td> Telomere length</td><td>0.86</td><td>[0.76, 0.97]</td><td>0.012</td></tr><tr><td> Hannum age</td><td>1.24</td><td>[1.11, 1.39]</td><td>1.3&#215;10<sup>-4</sup></td></tr><tr><td colspan="4">LBC1921 + LBC1936 (<i>n</i> = 1344, <i>n</i><sub>events</sub> = 415)</td></tr><tr><td> Age (years)</td><td>1.11</td><td>[1.08, 1.14]</td><td>&lt; 2 &#215; 10<sup>&#8722;16</sup></td></tr><tr><td> Sex (female)</td><td>0.82</td><td>[0.67, 1.01]</td><td>0.07</td></tr><tr><td> Telomere length</td><td>0.89</td><td>[0.79, 1.00]</td><td>0.047</td></tr><tr><td> Hannum age</td><td>1.25</td><td>[1.11, 1.40]</td><td>1.4&#215;10<sup>-4</sup></td></tr></table>
82e589e3a9f83286abe8f7a625cfc3b913002902849b0d5d220a3aa1005d41ef.png
complex
<table><tr><td rowspan="2">Studies</td><td colspan="3">Dystrophin IHC staining using FFPE muscle sections</td></tr><tr><td>Rod domain (DYS1)</td><td>C-terminus (DYS2)</td><td>N-terminus (DYS3)</td></tr><tr><td>Present study</td><td>Successful</td><td>Successful</td><td>Unsuccessful</td></tr><tr><td>Hoshino et al. 2000 [17]</td><td>Successful</td><td>Successful</td><td>Unsuccessful</td></tr><tr><td>Sheriffs et al. 2001 [18]</td><td>Successful</td><td>Successful</td><td>Successful</td></tr><tr><td>Sajid et al. 2010 [19]</td><td>Not performed</td><td>Successful</td><td>Not performed</td></tr></table>
9728474e7fd4e48582f14ebed42828259287d16590f3a6d21cf19387c0388ddf.png
complex
<table><tr><td></td><td colspan="2">Cases</td><td colspan="2">Controls</td><td colspan="2">Total</td></tr><tr><td></td><td>N</td><td>%</td><td>n</td><td>%</td><td>n</td><td>%</td></tr><tr><td>All subjects</td><td>603</td><td>33</td><td>1206</td><td>66</td><td>1809</td><td>100</td></tr><tr><td>Gender</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> Male</td><td>341</td><td>57</td><td>682</td><td>57</td><td>1023</td><td>57</td></tr><tr><td> Female</td><td>262</td><td>43</td><td>524</td><td>43</td><td>786</td><td>43</td></tr><tr><td>Age strata</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> 0-4 years</td><td>224</td><td>37</td><td>448</td><td>37</td><td>672</td><td>37</td></tr><tr><td> 5-9 years</td><td>176</td><td>29</td><td>352</td><td>29</td><td>528</td><td>29</td></tr><tr><td> 10-14 years</td><td>112</td><td>19</td><td>224</td><td>19</td><td>336</td><td>19</td></tr><tr><td> 15-19 years</td><td>91</td><td>15</td><td>182</td><td>15</td><td>273</td><td>15</td></tr><tr><td>Season</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> Summer</td><td>110</td><td>18</td><td>220</td><td>18</td><td>330</td><td>18</td></tr><tr><td> Autumn</td><td>172</td><td>29</td><td>344</td><td>29</td><td>516</td><td>29</td></tr><tr><td> Winter</td><td>192</td><td>32</td><td>384</td><td>32</td><td>576</td><td>32</td></tr><tr><td> Spring</td><td>129</td><td>21</td><td>258</td><td>21</td><td>387</td><td>21</td></tr></table>
ba7d3b1ca5130539bbc589d81d334eba4a270458cc37c256eacaecb89230e67d.png
complex
<table><tr><td>Block 1</td><td>SNPs</td><td></td><td colspan="10">Frequency of the haplotype</td></tr><tr><td></td><td>rs915941</td><td>rs915942</td><td>population</td><td>Group A</td><td>Group B</td><td>Males</td><td>Females</td><td>Males</td><td>Group B</td><td></td><td></td><td></td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td>Group A</td><td>Group A</td><td>Group B</td><td>Females</td><td></td><td></td><td></td></tr><tr><td rowspan="2">Haplotypes</td><td>A</td><td>G</td><td>0.880</td><td>0.890</td><td>0.870</td><td>-</td><td>0.870</td><td>0.878</td><td>0.871</td><td></td><td></td><td></td></tr><tr><td><i>C</i></td><td><i>A</i></td><td>0.119</td><td>0.110</td><td>0.124</td><td>-</td><td>0.120</td><td>0.122</td><td>0.126</td><td></td><td></td><td></td></tr><tr><td>Block 2</td><td>SNPs</td><td></td><td></td><td></td><td></td><td colspan="7">Frequency of the haplotype</td></tr><tr><td></td><td>rs2071429</td><td>rs2230037</td><td>rs4898389</td><td>rs5986877</td><td>rs7879049</td><td>Population (0.64)</td><td>Group A (0.73)</td><td>Group B (0.77)</td><td>Males Group A (N/R)</td><td>Females Group A (0.77)</td><td>Males Group B (0.76)</td><td>Females Group B (0.48)</td></tr><tr><td>Haplotypes</td><td>A</td><td>G</td><td>A</td><td>C</td><td>A</td><td>0.545</td><td>0.553</td><td>0.540</td><td>0.475</td><td>0.540</td><td>0.585</td><td>0.516</td></tr><tr><td></td><td><i>G</i></td><td><i>A</i></td><td><i>G</i></td><td><i>G</i></td><td><i>G</i></td><td>0.402</td><td>0.394</td><td>0.407</td><td>0.475</td><td>0.365</td><td>0.364</td><td>0.431</td></tr><tr><td></td><td><i>G</i></td><td>G</td><td><i>G</i></td><td><i>G</i></td><td>A</td><td>0.034</td><td>0.033</td><td>0.034</td><td>0.013</td><td>0.041</td><td>0.028</td><td>0.038</td></tr></table>
0765a3d46c269df63f6a653d6de98a0db6d5eeeab11e1f8440ab67d51b92bdd9.png
simple
<table><tr><td></td><td>Fatigue</td><td>Abdominal complaints</td><td>Musculo- skeletal complaints</td><td>Weight changes</td><td>Itch</td></tr><tr><td>Alkaline Phosphatase (AF)</td><td>x</td><td>x</td><td></td><td>x</td><td></td></tr><tr><td>Alanine aminotransferase (ALAT)</td><td>x</td><td>x</td><td></td><td>x</td><td>x</td></tr><tr><td>Amylase</td><td></td><td>x</td><td></td><td>x</td><td></td></tr><tr><td>Anti-endomysium</td><td></td><td>x</td><td></td><td>x</td><td></td></tr><tr><td>Aspartate aminotransferase (ASAT)</td><td>x</td><td>x</td><td></td><td>x</td><td></td></tr><tr><td>Bilirubin</td><td></td><td></td><td></td><td></td><td>x</td></tr><tr><td>Erythrocyte sedimentation rate (ESR)</td><td>x</td><td>x</td><td>x</td><td>x</td><td>x</td></tr><tr><td>Carbohydrate-deficient transferrin (CDT)</td><td>x</td><td>x</td><td></td><td>x</td><td>x</td></tr><tr><td>Creatinin kinase (CK)</td><td></td><td></td><td>x</td><td></td><td></td></tr><tr><td>Creatinin</td><td>x</td><td>x</td><td>x</td><td>x</td><td>x</td></tr><tr><td>C-reactive protein (CRP)</td><td></td><td>x</td><td></td><td></td><td></td></tr><tr><td>Differentiated leukocyte count</td><td>x</td><td>x</td><td></td><td>x</td><td>x</td></tr><tr><td>Eosinophils</td><td></td><td></td><td></td><td></td><td>x</td></tr><tr><td>Ferritin</td><td>x</td><td>x</td><td>x</td><td>x</td><td></td></tr><tr><td>Gamma glutamyl transferase (GGT)</td><td>x</td><td>x</td><td></td><td>x</td><td>x</td></tr><tr><td>Glucose</td><td>x</td><td>x</td><td>x</td><td>x</td><td>x</td></tr><tr><td>Haemoglobin (Hb)</td><td>x</td><td>x</td><td>x</td><td>x</td><td>x</td></tr><tr><td>Potassium (K)</td><td>x</td><td></td><td>x</td><td></td><td></td></tr><tr><td>Latex fixation test</td><td></td><td></td><td>x</td><td></td><td></td></tr><tr><td>Lactate dehydrogenase (LDH)</td><td>x</td><td></td><td></td><td>x</td><td></td></tr><tr><td>Leukocyte count</td><td>x</td><td>x</td><td></td><td>x</td><td>x</td></tr><tr><td>Monosticon</td><td>x</td><td></td><td></td><td></td><td></td></tr><tr><td>Total IgE</td><td></td><td>x</td><td></td><td></td><td>x</td></tr><tr><td>Thyroid stimulating hormone (TSH)</td><td>x</td><td>x</td><td>x</td><td>x</td><td>x</td></tr><tr><td>Transferrin saturation (TS)</td><td>x</td><td>x</td><td>x</td><td>x</td><td></td></tr><tr><td>Urea</td><td></td><td></td><td></td><td></td><td>x</td></tr><tr><td>Uric acid</td><td></td><td></td><td>x</td><td></td><td></td></tr><tr><td>Total number of tests</td><td>17</td><td>18</td><td>11</td><td>17</td><td>14</td></tr></table>
edad005393a3a7f7de3724be5b792a8b688506a6bd7b000551e12a2d32565609.png
simple
<table><tr><td>SNPs</td><td>Position</td><td>Genotypes and alleles</td><td>No</td><td>Frequencies, %</td></tr><tr><td>rs4693084</td><td>Intron 3</td><td>GG</td><td>91</td><td>61.5</td></tr><tr><td></td><td></td><td>GT</td><td>50</td><td>33.8</td></tr><tr><td></td><td></td><td>TT</td><td>7</td><td>4.7</td></tr><tr><td></td><td></td><td>G</td><td>232</td><td>78.4</td></tr><tr><td></td><td></td><td>T</td><td>64</td><td>21.6</td></tr><tr><td>rs4693083</td><td>Intron 3</td><td>AA</td><td>91</td><td>61.5</td></tr><tr><td></td><td></td><td>AT</td><td>50</td><td>33.8</td></tr><tr><td></td><td></td><td>TT</td><td>7</td><td>4.7</td></tr><tr><td></td><td></td><td>A</td><td>232</td><td>78.4</td></tr><tr><td></td><td></td><td>T</td><td>64</td><td>21.6</td></tr><tr><td>rs4693609</td><td>Intron 3</td><td>TT</td><td>88</td><td>59.5</td></tr><tr><td></td><td></td><td>TC</td><td>53</td><td>35.8</td></tr><tr><td></td><td></td><td>CC</td><td>7</td><td>4.7</td></tr><tr><td></td><td></td><td>T</td><td>229</td><td>77.4</td></tr><tr><td></td><td></td><td>C</td><td>67</td><td>22.6</td></tr><tr><td>rs4693608</td><td>Intron 3</td><td>AA</td><td>56</td><td>37.8</td></tr><tr><td></td><td></td><td>AG</td><td>62</td><td>41.9</td></tr><tr><td></td><td></td><td>GG</td><td>30</td><td>20.3</td></tr><tr><td></td><td></td><td>A</td><td>174</td><td>58.8</td></tr><tr><td></td><td></td><td>G</td><td>122</td><td>41.2</td></tr><tr><td>rs11099592</td><td>Exon 7</td><td>GG</td><td>91</td><td>61.5</td></tr><tr><td></td><td></td><td>GA</td><td>49</td><td>33.1</td></tr><tr><td></td><td></td><td>AA</td><td>8</td><td>5.4</td></tr><tr><td></td><td></td><td>G</td><td>231</td><td>78</td></tr><tr><td></td><td></td><td>A</td><td>65</td><td>22</td></tr></table>
bc1721d4a3bbfb59821d5b4b5f39820c8dad60188da2f3173b4d3afc55b82087.png
simple
<table><tr><td>Variable</td><td>Single etiologic agent(<i>n </i>= 126)</td><td>Multiple etiologic agents(<i>n </i>= 153)</td><td><i>P</i>-value</td></tr><tr><td><i>Gram-positive cocci</i></td><td></td><td></td><td></td></tr><tr><td>Aerobic</td><td></td><td></td><td></td></tr><tr><td> <i>Staphylococcus aureus</i></td><td></td><td></td><td></td></tr><tr><td>Methicillin-susceptible <i>S. aureus</i></td><td>27 (21.4)</td><td>15 (9.8)</td><td>0.007*</td></tr><tr><td>Methicillin-resistant <i>S. aureus</i></td><td>20 (15.9)</td><td>34 (22.2)</td><td>0.182</td></tr><tr><td> Coagulase-negative <i>Staphylococcus</i></td><td>2 (1.6)</td><td>11 (7.2)</td><td>0.042*</td></tr><tr><td> <i>Streptococcus</i></td><td></td><td></td><td></td></tr><tr><td>Beta-hemolytic (Group A)</td><td>13 (10.3)</td><td>24 (15.7)</td><td>0.188</td></tr><tr><td>Beta-hemolytic (Group B)</td><td>2 (1.6)</td><td>4 (2.6)</td><td>0.693</td></tr><tr><td>Non-group A or B</td><td>-</td><td>2 (0.7)</td><td>-</td></tr><tr><td><i>S. viridans</i></td><td>2(1.6)</td><td>36 (23.5)</td><td>&lt;0.001*</td></tr><tr><td> <i>Enterococcus faecalis</i></td><td>1(0.8)</td><td>45 (29.4)</td><td>&lt;0.001*</td></tr><tr><td>Anaerobic</td><td></td><td></td><td></td></tr><tr><td> <i>Peptostreptococcus</i></td><td>-</td><td>38 (13.6)</td><td>-</td></tr><tr><td><i>Gram-positive rods</i></td><td></td><td></td><td></td></tr><tr><td>Aerobic</td><td></td><td></td><td></td></tr><tr><td> <i>Corynebacterium</i></td><td>-</td><td>8 (2.9)</td><td>-</td></tr><tr><td>Anaerobic</td><td></td><td></td><td></td></tr><tr><td> <i>Clostridium spp</i>.</td><td>-</td><td>5 (1.8)</td><td>-</td></tr><tr><td><i>Gram negative rods</i></td><td></td><td></td><td></td></tr><tr><td>Aerobic</td><td></td><td></td><td></td></tr><tr><td> <i>Acinetobacter baumannii</i></td><td>3 (2.4)</td><td>20 (13.1)</td><td>0.001*</td></tr><tr><td> <i>Aeromonas </i>spp.</td><td>11 (8.7)</td><td>11 (7.2)</td><td>0.635</td></tr><tr><td> <i>Citrobacter </i>spp.</td><td>2 (1.6)</td><td>9 (5.9)</td><td>0.119</td></tr><tr><td> <i>E.coli</i>.</td><td>2 (1.6)</td><td>35 (22.9)</td><td>&lt;0.001*</td></tr><tr><td> <i>Enterobacter </i>spp.</td><td>1 (0.8)</td><td>19 (12.4)</td><td>&lt;0.001*</td></tr><tr><td> <i>Klebsiella pneumoniae</i></td><td>13 (10.3)</td><td>28 (18.3)</td><td>0.061</td></tr><tr><td> <i>Pseudomonas aeruginosa</i></td><td>3 (2.4)</td><td>16 (10.5)</td><td>0.008*</td></tr><tr><td> <i>Vibrio </i>spp.</td><td>21 (17.5)</td><td>-</td><td>-</td></tr><tr><td> <i>Eikenella corrodens</i></td><td>-</td><td>4 (2.6)</td><td>-</td></tr><tr><td> <i>Klebsiella oxytoca</i></td><td>-</td><td>3 (2.0)</td><td>-</td></tr><tr><td> <i>Proteus mirabillis</i></td><td>-</td><td>23 (15.0)</td><td>-</td></tr><tr><td> <i>Serratia marcescens</i></td><td>-</td><td>7 (4.6)</td><td>-</td></tr><tr><td> Other gram negative rods</td><td>1 (0.8)</td><td>15 (9.2)</td><td>0.002*</td></tr><tr><td>Anaerobic</td><td></td><td></td><td></td></tr><tr><td> <i>Prevotella </i>spp.</td><td>2 (1.6)</td><td>10 (6.5)</td><td>0.071</td></tr><tr><td> <i>Bacteroides fragilis</i></td><td>-</td><td>15 (9.8)</td><td>-</td></tr><tr><td> <i>Fusobacterium</i></td><td>-</td><td>1 (0.7)</td><td>-</td></tr><tr><td> <i>Veillonella</i></td><td>-</td><td>3 (2.0)</td><td>-</td></tr><tr><td><i>Fungus</i></td><td>-</td><td>6 (3.9)</td><td>-</td></tr></table>
6e1c7c85c7d6916df5aff13f9f60305c74dcec84737bd6d34a077a96bfd7650c.png
simple
<table><tr><td>Formulation</td><td>Aromatic Content in Polymer (%)</td><td>EE (%)</td><td>LC (%)</td></tr><tr><td>Cur-Nano1</td><td>0</td><td>61.3 &#177; 0.5</td><td>6.8 &#177; 0.1</td></tr><tr><td>Cur-Nano2</td><td>25</td><td>61.3 &#177; 0.1</td><td>6.8 &#177; 0.0</td></tr><tr><td>Cur-Nano3</td><td>100</td><td>113.8 &#177; 3.4</td><td>12.6 &#177; 0.4</td></tr></table>
6b86c294ce45e765d04b01b1388a8c343938b7d445dd9511ada64b1b641c82b3.png
simple
<table><tr><td>Outcome</td><td>Perceived labour &#8805;24 hours</td><td>Perceived labour &lt;24 hours</td><td>RR (95% CI)</td></tr><tr><td> </td><td>n = 434</td><td>n = 813</td><td> </td></tr><tr><td> </td><td>n (%)</td><td>n (%)</td><td> </td></tr><tr><td>Mode of birth</td><td> </td><td> </td><td> </td></tr><tr><td> Vaginal</td><td>189 (43.5)</td><td>412 (50.7)</td><td>0.86 (0.76-0.98)</td></tr><tr><td> Forceps or vacuum</td><td>122 (28.1)</td><td>237 (29.2)</td><td>0.96 (0.80&#8211;1.16)</td></tr><tr><td> Cesarean birth</td><td>123 (28.3)</td><td>164 (20.2)</td><td>1.40 (1.15-1.72)</td></tr><tr><td>Primary indication for cesarean</td><td> </td><td> </td><td> </td></tr><tr><td> Dystocia/CPD</td><td>99 (80.5)</td><td>122 (74.4)</td><td>1.08 (0.95-1.23)</td></tr><tr><td> Fetal Distress</td><td>24 (19.5)</td><td>42 (25.6)</td><td>0.76 (0.49&#8211;1.19)</td></tr><tr><td>Length of time from admission to birth (minutes, mean &#177; sd)</td><td>714.6 &#177; 467.9</td><td>580.7 &#177; 441.6</td><td>p &lt; .001</td></tr><tr><td>Length of first stage (minutes, mean &#177; sd)</td><td>916.1 &#177; 501.0</td><td>775.5 &#177; 417.8</td><td>p &lt; .001</td></tr><tr><td>Length of second stage (minutes, mean &#177; sd)</td><td>125.3 &#177; 92.5</td><td>118.1 &#177; 97.8</td><td>ns</td></tr><tr><td>Cervical dilation on admission &#8804; 3 cm</td><td>223 (52.0)</td><td>347 (43.3)</td><td>1.21 (1.07-1.36)</td></tr><tr><td>Continuous Electronic Fetal Monitoring</td><td>316 (72.8)</td><td>533 (65.6)</td><td>1.11 (1.03-1.20)</td></tr><tr><td>IV fluids</td><td>384 (88.5)</td><td>629 (77.6)</td><td>1.14 (1.08&#8211;1.20)</td></tr><tr><td>Augmentation of labour</td><td>331 (76.3)</td><td>65 (57.2)</td><td>1.33 (1.23&#8211;1.44)</td></tr><tr><td>Analgesia</td><td> </td><td> </td><td> </td></tr><tr><td> Narcotic (IM or IV)</td><td>206 (47.5)</td><td>320 (39.4)</td><td>1.21 (1.06&#8211;1.37)</td></tr><tr><td> Nitrous Oxide</td><td>294 (67.7)</td><td>568 (69.9)</td><td>0.97 (0.90&#8211;1.05)</td></tr><tr><td> Epidural analgesia</td><td>327 (75.3)</td><td>495 (60.9)</td><td>1.18 (1.09&#8211;1.28)</td></tr><tr><td>Blood loss</td><td> </td><td> </td><td> </td></tr><tr><td> After vaginal birth (&gt;500 cc)</td><td>65 (19.9)</td><td>112 17.2)</td><td>1.21 (0.92-1.59)</td></tr><tr><td> After cesarean birth (&gt;1000 cc)</td><td>5 (4.1)</td><td>6 (3.7)</td><td>1.11 (0.353.56)</td></tr></table>
30180f99ab14d05da9cb345dfa3cd3d8b119e096a3fe4290efac5fb9bac8df47.png
complex
<table><tr><td rowspan="2">Laboratory ID</td><td rowspan="2">Laboratory type</td><td colspan="3">Correct diagnosis</td></tr><tr><td>All Specimens, n (%)</td><td>Smear-Positive Specimens, n (%)</td><td>Smear-Negative Specimens, n (%)</td></tr><tr><td>1</td><td>Network</td><td>3 (42.9)</td><td>2 (33.3)</td><td>1 (100)</td></tr><tr><td>2</td><td>Network</td><td>7 (100)</td><td>6 (100)</td><td>1 (100)</td></tr><tr><td>3</td><td>Standalone</td><td>1 (14.3)</td><td>0 (0)</td><td>1 (100)</td></tr><tr><td>4</td><td>Standalone</td><td>1 (14.3)</td><td>0 (0)</td><td>1 (100)</td></tr><tr><td>5</td><td>Network</td><td>1 (14.3)</td><td>0 (0)</td><td>1 (100)</td></tr><tr><td>6</td><td>Standalone</td><td>6 (85.7)</td><td>6 (100)</td><td>0 (0)</td></tr><tr><td>7</td><td>Network</td><td>7 (100)</td><td>6 (100)</td><td>1 (100)</td></tr><tr><td>Indus Hospital</td><td>N/A</td><td>7 (100)</td><td>6 (100)</td><td>1 (100)</td></tr></table>
c8e0f56f52e4d7fae510a9d64d4093aaba04eb11ba06bd929c89b294286e53ad.png
simple
<table><tr><td>Reference/reference number</td><td>Surrogate product</td><td>Countries</td><td>Study population</td><td>Method</td></tr><tr><td>Green [59]</td><td>Female condom, foaming tablets, contraceptive sponge, Delfen foam, film and gel</td><td>Uganda</td><td>131 women; 21 men</td><td>Qual</td></tr><tr><td>Jones [33]</td><td>Astroglide Silken Secret (high-viscosity gel), KY Jelly (low-viscosity gel), Lubrin (suppository)</td><td>Zambia</td><td>301 women</td><td>Quant</td></tr><tr><td>Martin [15]</td><td>Gel</td><td>Thailand</td><td>23 women; 28 men</td><td>Qual</td></tr><tr><td>Montgomery [20]</td><td>Gel</td><td>South Africa, Tanzania, Uganda, Zambia</td><td>45 couples</td><td>Qual</td></tr><tr><td>Pool [48]</td><td>Female condom, foaming tablets, contraceptive sponge, Delfen foam, film and gel</td><td>Uganda</td><td>138 women; 42 men</td><td>Qual</td></tr><tr><td>Salter [43]</td><td>Gel</td><td>Malawi</td><td>1686 women; 21 men</td><td>Mixed</td></tr><tr><td>Tanner [21]</td><td>Silken Secret vaginal moisturizer</td><td>USA</td><td>40 women</td><td>Qual</td></tr><tr><td>van der Straten [61]</td><td>Ring</td><td>South Africa, Tanzania</td><td>157 women; 19 men</td><td>Qual</td></tr><tr><td>Weeks [74]</td><td>Vaginal moisturizer</td><td>USA</td><td>546 women interviewed/surveyed; 94 participating in surrogate trial</td><td>Mixed</td></tr></table>
1415dc5fcbf835384f271d75732ef751e77243e8b0db926a03d1bba12a394c38.png
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<table><tr><td>Research Authors (Year)</td><td>Purpose</td><td>Characteristics</td><td>Outcomes</td></tr><tr><td>Alwan et al. [110] (2006)</td><td>Fall detection</td><td>The authors used dummies of humans to simulate original fall events. The experimental tests of falls were performed on concrete floors. A dummy was used to emulate the scenario of a person falling while attempting to get out of a chair. Another dummy was used to emulate the scenario of a person falling with upright position. The experiments were repeated three times with the same dummies.</td><td>100% accuracy.</td></tr><tr><td>Lombardi et al. [111] (2015)</td><td>Movement detection</td><td>A data model was proposed for storing and processing floor data. The proposed approach focused on estimating the center of floor pressure based on the widely used biomechanical concept of ground reaction force. Some practical tests on a real sensing floor prototype were attempted. The novel approach outperformed the traditional background subtraction schemas for the correct detection and tracking of people.</td><td>97% accuracy.</td></tr><tr><td>Serra et al. [112] (2014)</td><td>Footstep recognition</td><td>An easy-to-install and unobtrusive smart flooring system was proposed based on piezoelectric polymer floor sensors. The smart flooring system was utilized for efficient human footsteps recognition based on the Pearson product&#8211;moment correlation coefficient between the testing and reference signals for similarity calculation.</td><td>99% accuracy.</td></tr></table>
353f665155cb76cb74f1c69b70bd528d5e98264f2f66f2228d1734da992d2b46.png
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<table><tr><td rowspan="2"></td><td colspan="3">LDA</td><td colspan="3">SVM (Linear)</td></tr><tr><td>Accuracy</td><td>Precision</td><td>Recall</td><td>Accuracy</td><td>Precision</td><td>Recall</td></tr><tr><td>Forehead_axis + Mouth_axis</td><td>77.8</td><td>76.9</td><td>66.7</td><td>77.8</td><td>76.9</td><td>66.7</td></tr><tr><td>Forehead_axis + Mouth_region</td><td>66.7</td><td>46.2</td><td>54.6</td><td>63.9</td><td>46.2</td><td>50.0</td></tr><tr><td>Forehead_region + Mouth_axis</td><td>88.9</td><td>92.3</td><td>80.0</td><td>88.9</td><td>92.3</td><td>80.0</td></tr><tr><td>Forehead_region + Mouth_region</td><td>75.0</td><td>85.7</td><td>63.2</td><td>77.8</td><td>84.6</td><td>64.7</td></tr></table>
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<table><tr><td>Time</td><td>0 h</td><td>2 h</td><td>12 h</td><td>24 h</td></tr><tr><td>Intensity of FSC</td><td>320.3 &#177; 34.3</td><td>359.1 &#177; 34.4</td><td>382.0 &#177; 38.4</td><td>410.7 &#177; 51.1</td></tr></table>
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<table><tr><td>Species</td><td>No tested</td><td colspan="6">No of positive humans, buffaloes and a lion (Prevalence)</td><td></td><td></td></tr><tr><td></td><td></td><td colspan="2">RBPT</td><td colspan="2">BAPA</td><td colspan="2">Riv.T</td><td>95 % CI</td><td>TITER</td></tr><tr><td></td><td></td><td>No</td><td>% positive</td><td>No</td><td>%Positive</td><td>No</td><td>% positive</td><td></td><td></td></tr><tr><td>Humans</td><td>340</td><td>5</td><td>1.5</td><td>2</td><td>0.6</td><td>2</td><td>0.6</td><td>0.1, 2.1</td><td>1:200<sup>*</sup></td></tr><tr><td>Buffaloes</td><td>38</td><td>4</td><td>10.5</td><td>3</td><td>7.9</td><td>3</td><td>7.9</td><td>1.7, 21.4</td><td>1:200<sup>*</sup></td></tr><tr><td>Lion</td><td>2</td><td>1</td><td>1/2</td><td>1</td><td>1/2</td><td>1</td><td>1/2</td><td></td><td>1:200<sup>*</sup></td></tr><tr><td>Zebra</td><td>2</td><td>0</td><td>0</td><td>0</td><td></td><td>0</td><td>0</td><td></td><td></td></tr></table>
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<table><tr><td>Characteristic</td><td>Value</td></tr><tr><td>Age, years</td><td> </td></tr><tr><td> Mean &#177; SD </td><td>58.2 &#177; 13.6</td></tr><tr><td> Range</td><td>30&#8211;92</td></tr><tr><td>Sex, % (<i>n</i>)</td><td> </td></tr><tr><td> Male</td><td>78.1 (25)</td></tr><tr><td> Female</td><td>21.9 (7)</td></tr><tr><td>Race/ethnicity % (<i>n</i>)</td><td> </td></tr><tr><td> Caucasian/white</td><td>59.4 (19)</td></tr><tr><td> African-American/black</td><td>31.3 (10)</td></tr><tr><td> Asian/Pacific Islander</td><td>9.4 (3)</td></tr><tr><td>Marital status, % (<i>n</i>)</td><td> </td></tr><tr><td> Married</td><td>28.1 (9)</td></tr><tr><td> Single</td><td>40.6 (13)</td></tr><tr><td> Other (widowed/divorced)</td><td>31.3 (10)</td></tr><tr><td>Smoking </td><td> </td></tr><tr><td>History of smoking, % (<i>n</i>)</td><td>75.0 (24)</td></tr><tr><td>Pack years, mean &#177; SD</td><td>21.0 &#177; 20.7</td></tr><tr><td>History of hypertension, % (<i>n</i>)</td><td>71.9 (23)</td></tr><tr><td>Creatinine on admission (g/dL), mean &#177; SD</td><td>1.9 &#177; 1.7</td></tr><tr><td>Etiology of heart failure, % (<i>n</i>)</td><td> </td></tr><tr><td> Ischemic</td><td>28.1 (9)</td></tr><tr><td> Idiopathic</td><td>65.6 (21)</td></tr><tr><td> Unknown/other</td><td>6.3 (2)</td></tr><tr><td>Ejection fraction &lt;40%, % (<i>n</i>)</td><td>71.9 (23)</td></tr><tr><td>ACEi/ARB use&#8212;study end, % (<i>n</i>)</td><td>62.5 (20)</td></tr><tr><td>Beta blocker use&#8212;study end, % (<i>n</i>)</td><td>78.1 (25)</td></tr><tr><td>High-risk diagnoses for the elderly scale </td><td> </td></tr><tr><td> Low (0) = 9.5% chance dying in 1 year</td><td>0 (0)</td></tr><tr><td> Intermediate (1-2) = 31% chance</td><td>53.1 (17)</td></tr><tr><td> High risk (3&#8211;5) = 46% chance</td><td>31.3 (10)</td></tr><tr><td> Very high risk (&#8805;6) = 74% chance</td><td>15.6 (5)</td></tr><tr><td>Length of hospital stay, days</td><td> </td></tr><tr><td> Mean &#177; SD</td><td>9.5 &#177; 9.9</td></tr><tr><td> Median</td><td>6.5</td></tr><tr><td> Range</td><td>1&#8211;41</td></tr><tr><td>Physical therapy&#8212;in hospital, % (<i>n</i>)</td><td>34.4 (11)</td></tr><tr><td>LVAD received during study admission, % (<i>n</i>)</td><td>6.3 (2)</td></tr><tr><td>Discharged with physical therapy, occupational therapy, or home health, % (<i>n</i>)</td><td>40.6 (13)</td></tr><tr><td>Cardiac events&#8212;90 days after discharge, % (<i>n</i>)</td><td> </td></tr><tr><td> Cardiac readmission</td><td>34.4 (11)</td></tr><tr><td> Heart transplant </td><td>3.1 (1)</td></tr><tr><td> Mortality</td><td>9.4 (3)</td></tr></table>
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<table><tr><td></td><td>Before treatment</td><td>After 1 month</td><td><i>P</i> value</td><td>After 6 months</td><td><i>P</i> value</td><td>After 12 months</td><td><i>P</i> value</td><td>Follow-up</td><td><i>P</i> value</td></tr><tr><td colspan="10">Group A Peg-IFN &#945; + RBV + placebo (<i>n</i> = 31)</td></tr><tr><td> Work ability index</td><td>36.9 &#177; 5.2</td><td>21.4 &#177; 5.3</td><td>&lt;0.01</td><td>37.8 &#177; 5.9</td><td>NS</td><td>38.7 &#177; 5.8</td><td>NS</td><td>39.8 &#177; 6.7</td><td>&lt;0.001</td></tr><tr><td> STAI</td><td>50.1 &#177; 7.6</td><td>59.2 &#177; 7.4</td><td>&lt;0.01</td><td>60.4 &#177; 7.7</td><td>&lt;0.001</td><td>58.2 &#177; 7.4</td><td>&lt;0.001</td><td>61.4 &#177; 7.2</td><td>&lt;0.001</td></tr><tr><td> BDI</td><td>30.8 &#177; 6.9</td><td>44.6 &#177; 6.7</td><td>&lt;0.01</td><td>46.7 &#177; 6.8</td><td>&lt;0.001</td><td>40.9 &#177; 6.9</td><td>&lt;0.001</td><td>40.4 &#177; 6.2</td><td>&lt;0.001</td></tr><tr><td colspan="10">Group B Peg IFN &#945; + RBV + Silybin, Vit E, phospholipids (<i>n</i> = 31)</td></tr><tr><td> Work ability index</td><td>35.4 &#177; 5.9</td><td>30.2 &#177; 6.2</td><td>&lt;0.001</td><td>38.4 &#177; 6.8</td><td>NS</td><td>40.7 &#177; 6.1</td><td>&lt;0.05</td><td>39.8 &#177; 6.4</td><td>&lt;0.05</td></tr><tr><td> STAI</td><td>50.8 &#177; 7.9</td><td>59.8 &#177; 7.1</td><td>&lt;0.001</td><td>50.4 &#177; 7.2</td><td>NS</td><td>47.4 &#177; 7.8</td><td>NS</td><td>50.6 &#177; 7.0</td><td>NS</td></tr><tr><td> BDI</td><td>30.7 &#177; 7.1</td><td>48.7 &#177; 7.8</td><td>&lt;0.001</td><td>34.6 &#177; 7.1</td><td>NS</td><td>30.1 &#177; 7.2</td><td>NS</td><td>30.4 &#177; 6.8</td><td>NS</td></tr></table>
a09df775504ef960f6db740ae821283667bdf63fc5ea5641d40e8d656449655c.png
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<table><tr><td></td><td colspan="5">MMQL-UK (PF) component</td></tr><tr><td>MMQL-UK (CF) component</td><td>Physical Appearance</td><td>School</td><td>Social Functioning</td><td>Emotional Functioning</td><td>Physical Functioning</td></tr><tr><td>Physical Appearance</td><td>0.51**</td><td>0.05</td><td>0.20**</td><td>0.25**</td><td>0.12**</td></tr><tr><td>School</td><td>0.13**</td><td>0.56**</td><td>0.22*</td><td>0.14**</td><td>0.21**</td></tr><tr><td>Social Functioning</td><td>0.14**</td><td>0.10*</td><td>0.31**</td><td>0.23**</td><td>0.18**</td></tr><tr><td>Emotional Functioning</td><td>0.35**</td><td>0.20**</td><td>0.26**</td><td>0.38**</td><td>0.25**</td></tr><tr><td>Physical Activities</td><td>0.33**</td><td>0.25**</td><td>0.21**</td><td>0.27**</td><td>0.61**</td></tr></table>
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<table><tr><td rowspan="2">Variable</td><td colspan="3">Non-diabetic individuals</td><td colspan="3">All IR individuals</td></tr><tr><td>IS(<i>n</i> = 16 [6 M, 10 F])</td><td>IR(<i>n</i> = 27 [(10 M, 17 F])</td><td>IS vs IR<i>p</i> value</td><td>T2DM(<i>n</i> = 14 [(4 M, 10 F])</td><td>IR + T2DM(<i>n</i> = 41, [14 M, 27 F])</td><td>IS vs IR + T2D<i>p</i> value</td></tr><tr><td>Age (years)</td><td>36.6 (11.8)</td><td>33.9 (8.1)</td><td>0.3</td><td>41.2 (10.8)</td><td>36.4 (9.7)</td><td>0.96</td></tr><tr><td>BMI (kg/m<sup>2</sup>)</td><td>42.9 (5.0)</td><td>44.3 (7.1)</td><td>0.57</td><td>43.5 (7.1)</td><td>44.0 (7.0)</td><td>0.55</td></tr><tr><td>SBP (mmHg)</td><td>127.1 (18.3)</td><td>126.9 (23.2)</td><td>0.69</td><td>128.2 (10.2)</td><td>127.3 (19.6)</td><td>0.98</td></tr><tr><td>DBP (mmHg)</td><td>71.29 (9.5)</td><td>72.78 (14.6)</td><td>0.98</td><td>73.86 (8.9)</td><td>73.2 (12.8)</td><td>0.62</td></tr><tr><td>MAP (mmHg)</td><td>89.90 (9.0)</td><td>90.81 (14.6)</td><td>0.85</td><td>92.4 (9.0)</td><td>91.4 (12.9)</td><td>0.70</td></tr><tr><td>Cholesterol (mmol/l)</td><td>4.48 (0.9)</td><td>5.0 (0.9)</td><td>0.53</td><td>5.10 (0.7)</td><td>5.0 (0.8)</td><td>0.04</td></tr><tr><td>LDL-cholesterol (mmol/l)</td><td>2.75 (0.6)</td><td>3.21 (1.0)</td><td>0.94</td><td>2.95 (0.8)</td><td>3.1 (0.9)</td><td>0.16</td></tr><tr><td>Triacylglycerol (mmol/l)</td><td>1.0 (0.8&#8211;1.4)</td><td>1.3 (0.9&#8211;1.9)</td><td>0.50</td><td>1.6 (1.3&#8211;2.8)</td><td>1.4 (1.0&#8211;2.1)</td><td>0.02</td></tr><tr><td>HDL-cholesterol (mmol/l)</td><td>1.25 (0.29)</td><td>1.20 (0.22)</td><td>0.15</td><td>1.24 (0.29)</td><td>1.2 (0.24)</td><td>0.67</td></tr><tr><td>FPG (mmol/l)</td><td>4.9 (0.5)</td><td>5.8 (0.9)</td><td>0.11</td><td>9.58 (5.81)</td><td>7.3 (3.8)</td><td>&lt;0.01</td></tr><tr><td>Insulin (pmol/l)</td><td>50.7 (34.0&#8211;59.03)</td><td>99.3 (79.2&#8211;145.2)</td><td>&lt;0.01</td><td>99.3 (71.5&#8211;138.2)</td><td>99.3 (78.5&#8211;141.7)</td><td>&lt;0.01</td></tr><tr><td>HOMA-IR</td><td>1.5 (1.1&#8211;1.9)</td><td>3.9 (3.0&#8211;6.6)</td><td>&lt;0.01</td><td>6.0 (3.4&#8211;9.0)</td><td>4.3 (3.0&#8211;7.2)</td><td>&lt;0.01</td></tr><tr><td>Albumin (g/l)</td><td>41.5 (36.3&#8211;44.0)</td><td>42.0 (38.5&#8211;45.5)</td><td>0.40</td><td>42.0 (39.8&#8211;44.3)</td><td>42.0 (39.0&#8211;44.0)</td><td>0.34</td></tr><tr><td>ALP (U/l)</td><td>67.0 (57.0&#8211;102.0)</td><td>73.0 (58.5&#8211;82.3)</td><td>0.48</td><td>83.5 (60.5&#8211;117.3)</td><td>74.0 (59.8&#8211;85.8)</td><td>0.85</td></tr><tr><td>ALT (U/l)</td><td>17.0 (11.0&#8211;21.0)</td><td>23.0 (19.0&#8211;27.0)</td><td>0.03</td><td>29.5 (13.8&#8211;39.8)</td><td>24.0 (17.0&#8211;45.0)</td><td>&lt;0.01</td></tr><tr><td>AST (U/l)</td><td>18.0 (16.0&#8211;19.0)</td><td>23.5 (15.0&#8211;29.3)</td><td>0.02</td><td>21.5 (14.0&#8211;32.5)</td><td>23.0 (15.0&#8211;30.8)</td><td>0.05</td></tr><tr><td>Bilirubin (&#956;mol/l)</td><td>8.0 (6.5&#8211;13.0)</td><td>8.0 (5.8&#8211;10.3)</td><td>0.54</td><td>5.0 (4.0&#8211;7.3)</td><td>6.5 (5.0&#8211;9.0)</td><td>0.17</td></tr></table>
430e2b33f7a4aef3fb7f547554fb78da9817140a8a4402ade741e9cd09c4f342.png
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<table><tr><td> </td><td>Georgia</td><td>Cobb County, GA</td><td>Dekalb County, GA</td><td>Fulton County, GA</td><td>Gwinnett County, GA</td></tr><tr><td>Total Asian</td><td>320,905</td><td>31,164</td><td>37,095</td><td>52,213</td><td>86,957</td></tr><tr><td>Chinese (except Taiwanese)</td><td>44,604</td><td>4,961</td><td>5,767</td><td>10,025</td><td>10,624</td></tr><tr><td>Taiwanese</td><td>3,483</td><td>378</td><td>525</td><td>959</td><td>886</td></tr></table>
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<table><tr><td>Disinfectant</td><td>Concentrations tested (contact time in minutes used)</td><td>Effective</td><td>Level of Evidence</td><td>Comments</td><td>Reference</td></tr><tr><td>Chlorhexidine gluconate</td><td>&lt;0.02% (1440), 0.5% (0.5), 2% (2), 4% (3, 180, 1800)</td><td>Yes</td><td>Good</td><td>Most studied antiseptic. Limited clinical evaluation.</td><td>Schelenz et al., 2016; Abdolrasouli et al., 2017; Moore et al., 2017; Sherry et al., 2017</td></tr><tr><td>Chlorhexidine gluconate in isopropyl alcohol</td><td>2%/70% (2)</td><td>Yes</td><td>Low</td><td><i>In vitro</i> testing only.</td><td>Moore et al., 2017</td></tr><tr><td>Povidone-iodine</td><td>10% (2, 3, 180, 1800)</td><td>Yes</td><td>Moderate</td><td><i>In vitro</i> testing only.</td><td>Abdolrasouli et al., 2017; Moore et al., 2017;</td></tr><tr><td>Alcohol</td><td>70%</td><td>Yes</td><td>Low</td><td>Limited clinical evaluation.</td><td>Biswal et al., 2017</td></tr></table>
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<table><tr><td></td><td>Hyperkalaemia (&#8805;6 mmol/L)*</td><td>Creatinine &#8805;220 &#956;mol/L</td><td>&#8805;30% increase in creatinine</td></tr><tr><td>Number with adverse biochemical values&#8224;</td><td>128/6373 (2.0%)</td><td>177/6520 (2.7%)</td><td>877/6520 (13.5%)</td></tr><tr><td>Number discontinuing AA&#8225;</td><td>68/128 (53.1%)</td><td>76/177 (42.9%)</td><td>251/877 (28.6%)</td></tr></table>
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<table><tr><td>Clean-up method</td><td>According to reference</td><td>Total solvent (mL)</td><td>Time (h)</td><td>Swelling (%)</td><td>Release of oligomers (%)</td></tr><tr><td>Soxhlet extraction ethylacetate</td><td>Smedes and Booij (2012)</td><td>400</td><td>100</td><td>92</td><td>2.5</td></tr><tr><td>Extraction ethylacetate</td><td>Shahpoury and Hageman (2013)</td><td>400</td><td>48</td><td>76</td><td>2.4</td></tr><tr><td>Extraction <i>n</i>-hexane/acetone (3:1)</td><td>Scha&#776;fer et al.(2010)</td><td>800</td><td>96</td><td>124</td><td>2.5</td></tr><tr><td>ASE <i>n</i>-hexane/acetone (1:1)</td><td>This study</td><td>169</td><td>1.2</td><td>42</td><td>2.2</td></tr></table>
057a01617977f3e95b8edc71286b7b7570db5c76aaa8c900629840fd7ef7a951.png
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<table><tr><td></td><td colspan="2">Recurrence</td><td colspan="2">No recurrence</td><td>p value</td></tr><tr><td>n</td><td>9</td><td></td><td>187</td><td></td><td></td></tr><tr><td>Mean age (SD)</td><td>55.3</td><td>(13.9)</td><td>55.9</td><td>(12.1)</td><td>n.s.</td></tr><tr><td>Stage<sup>a</sup></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>I</td><td>2</td><td></td><td>87</td><td></td><td></td></tr><tr><td>IIA or B</td><td>4</td><td></td><td>96</td><td></td><td>&lt;0.01</td></tr><tr><td>IIIA or B</td><td>3</td><td></td><td>4</td><td></td><td></td></tr><tr><td>Histology</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Ductal</td><td>7</td><td></td><td>161</td><td></td><td></td></tr><tr><td>Lobular</td><td>2</td><td></td><td>11</td><td></td><td>n.s.</td></tr><tr><td>Others</td><td>0</td><td></td><td>15</td><td></td><td></td></tr><tr><td>High nuclear grade</td><td>11%</td><td>(1/9)</td><td>4%</td><td>(7/181)</td><td>n.s.</td></tr><tr><td>High histological grade</td><td>22%</td><td>(2/9)</td><td>4%</td><td>(6/141)</td><td>n.s.</td></tr><tr><td>ER<sup>b</sup></td><td>100%</td><td>(9/9)</td><td>100%</td><td>(187/187)</td><td>n.s.</td></tr><tr><td>PR<sup>b</sup></td><td>67%</td><td>(6/9)</td><td>78%</td><td>(145/187)</td><td>n.s.</td></tr><tr><td>Mean Ki67 (%) (SD)</td><td>37.9</td><td>(21.7)</td><td>24.1</td><td>(18.5)</td><td>&lt;0.05</td></tr><tr><td>(Neo-) adjuvant therapy</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Endocrine + chemotherapy</td><td>9</td><td></td><td>52</td><td></td><td></td></tr><tr><td>Endocrine therapy only</td><td>0</td><td></td><td>127</td><td></td><td></td></tr><tr><td>Chemotherapy only</td><td>0</td><td></td><td>1</td><td></td><td></td></tr><tr><td>None</td><td>0</td><td></td><td>7</td><td></td><td></td></tr></table>
a028791f03911a3fa834f4fae7498cf9e6718282f27ae5fe67cb66aab67c244f.png
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<table><tr><td>Category</td><td>Value</td></tr><tr><td>Total patients enrolled</td><td>80</td></tr><tr><td>Number of groups</td><td>15</td></tr><tr><td>Number of geographic areas with groups</td><td>9</td></tr><tr><td>Average number of patients per group</td><td>5.3</td></tr><tr><td>Female, number (%)</td><td>51 (63.8%)</td></tr><tr><td>Age at enrollment (years), median (IQR)</td><td>44 (36&#8211;51)</td></tr><tr><td>CD4 count at enrollment (cells/mL), median (IQR)</td><td>509 (382&#8211;670)</td></tr><tr><td>Months on ART prior to enrollment, median (IQR)</td><td>45.2 (22.4&#8211;65.6)</td></tr></table>
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<table><tr><td></td><td>Group 1 (dose escalation)</td><td>Group 2 (1.35 &#215; 10<sup>5</sup> PfSPZ)</td><td>Group 3 (2.7 &#215; 10<sup>5</sup> PfSPZ)</td><td>Group 4 (2.7 &#215; 10<sup>5</sup> PfSPZ)</td><td>Total PfSPZ vaccine</td><td>NS controls</td></tr><tr><td>Number of volunteers</td><td>3</td><td>20</td><td>20</td><td>6</td><td>49</td><td>8</td></tr><tr><td>Total number of injections</td><td>9</td><td>99</td><td>100</td><td>29</td><td>237</td><td>40</td></tr><tr><td>Number of local AEs</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td></tr><tr><td colspan="7">Numbers of systemic AEs (% of total immunizations)</td></tr><tr><td> All</td><td>1 (11%)</td><td>10 (10.1%)</td><td>6 (6%)</td><td>0</td><td>17 (7.2%)</td><td>2 (5.0%)</td></tr><tr><td> Headache*</td><td>1 (11%)</td><td>7 (7%)&#8224;</td><td>2 (2%)</td><td>0</td><td>10 (4.2%)</td><td>1 (2.5%)</td></tr><tr><td> Abdominal pain</td><td>0</td><td>2 (2%)</td><td>1 (1%)</td><td>0</td><td>3 (1.3%)</td><td>0</td></tr><tr><td> Chills</td><td>0</td><td>0</td><td>1 (1%)</td><td>0</td><td>1 (0.4%)</td><td>0</td></tr><tr><td> Fever</td><td>0</td><td>0</td><td>2 (2%)</td><td>0</td><td>2 (0.8%)</td><td>0</td></tr><tr><td> Diarrhea</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>1 (2.5%)</td></tr><tr><td> Chest pain</td><td>0</td><td>1 (1%)</td><td>0</td><td>0</td><td>1 (0.4%)</td><td>0</td></tr><tr><td> Other</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td></tr><tr><td colspan="7">Systemic AEs - no. volunteers with &#8805; 1 event (% of volunteers)</td></tr><tr><td> Any</td><td>1 (33%)</td><td>7 (35%)</td><td>2 (10%)</td><td>0</td><td>10 (20.4%)</td><td>1 (13%)</td></tr><tr><td> Headache</td><td>1 (33%)</td><td>6 (30%)</td><td>2 (10%)</td><td>0</td><td>9 (18.4%)</td><td>1 (13%)</td></tr><tr><td> Abdominal pain</td><td>0</td><td>2 (10%)</td><td>1 (5%)</td><td>0</td><td>3 (6.1%)</td><td>0</td></tr><tr><td> Chills</td><td>0</td><td>0</td><td>1 (5%)</td><td>0</td><td>1 (2.0%)</td><td>0</td></tr><tr><td> Fever</td><td>0</td><td>0</td><td>2 (10%)</td><td>0</td><td>2 (4.1%)</td><td>0</td></tr><tr><td> Diarrhea</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>1 (13%)</td></tr><tr><td> Chest pain</td><td>0</td><td>1 (5%)</td><td>0</td><td>0</td><td>1 (2.0%)</td><td>0</td></tr><tr><td> All other</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td></tr></table>
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<table><tr><td>Clinicopathological features</td><td>n</td><td>China</td><td>n</td><td>Japan</td></tr><tr><td>Age(mean +SD, yr)</td><td>9793</td><td>59.25+9.83*</td><td>162</td><td>68.77+8.82</td></tr><tr><td>Sex(male : female)</td><td>9776</td><td>6151:3625*</td><td>154</td><td>104:50</td></tr><tr><td>Tumor size(&lt;3cm:&#8805;3cm)</td><td>2132</td><td>1062:1070*</td><td>99</td><td>72:27</td></tr><tr><td>Lymph node metastasis(+)</td><td>2324</td><td>1013(43.6) *</td><td>153</td><td>54(35.3)</td></tr><tr><td>Histological type</td><td>8948</td><td></td><td>156</td><td></td></tr><tr><td> Adenocarcinoma</td><td></td><td>4910(54.9)</td><td></td><td>86(55.1)</td></tr><tr><td> Squamous cell carcinoma</td><td></td><td>3270(36.5) *</td><td></td><td>38(24.4)</td></tr><tr><td> Small cell carcinoma</td><td></td><td>494(5.5) *</td><td></td><td>18(9.0)</td></tr><tr><td> Large cell carcinoma</td><td></td><td>274(3.1) *</td><td></td><td>14(11.5)</td></tr><tr><td>TNM staging</td><td>2608</td><td></td><td>101</td><td></td></tr><tr><td> I</td><td></td><td>1030(39.49) *</td><td></td><td>61(60.4)</td></tr><tr><td> II</td><td></td><td>533(20.4)</td><td></td><td>13(12.9)</td></tr><tr><td> III</td><td></td><td>846(32.4)</td><td></td><td>26(25.7)</td></tr><tr><td> IV</td><td></td><td>199(7.6) *</td><td></td><td>1(1.0)</td></tr></table>
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<table><tr><td colspan="4">PhenX family history of MI?</td><td colspan="4">PMRP family history of MI/Angina</td></tr><tr><td colspan="2">Yes</td><td colspan="2">No</td><td colspan="2">Yes</td><td colspan="2">No</td></tr><tr><td>N</td><td>%</td><td>N</td><td>%</td><td>N</td><td>%</td><td>N</td><td>%</td></tr><tr><td>1108</td><td>52.8</td><td>991</td><td>47.2</td><td>589</td><td>28.1</td><td>1510</td><td>71.9</td></tr><tr><td colspan="8">Kappa=0.352 (95% CL=0.317, 0.386)</td></tr></table>
6831a5b5fc45ca20d63e1d6bc0702d86f23c6f2bbcf94a0ef32278bfdf4645af.png
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<table><tr><td>Combined category</td><td>Includes</td><td>Constructed for wave</td></tr><tr><td>Any mood disorder</td><td>MDD, Dysthymia</td><td>1 and 2</td></tr><tr><td>Any anxiety disorder W1</td><td>Panic disorder, Agoraphobia without a history of panic disorder, Specific phobias, Social phobia, GAD, OCD, PTSD.</td><td>1</td></tr><tr><td>Any Anxiety disorder W1&#8211;2</td><td>Panic disorder, Agoraphobia without a history of panic disorder, Specific phobias, Social phobia, GAD.</td><td>1 and 2</td></tr><tr><td>Any anxiety disorder W1&#8211;2 excluding specific phobias</td><td>Panic disorder, Agoraphobia without a history of panic disorder, Social phobia, GAD.</td><td>1 and 2</td></tr><tr><td>AUD</td><td>Alcohol abuse, Alcohol dependence.</td><td>1 and 2</td></tr><tr><td>Any mental disorder W1</td><td>Any mood disorder, Any anxiety disorder W1, AUD.</td><td>1</td></tr><tr><td>Any mental disorder W1&#8211;2</td><td>Any mood disorder, Any anxiety disorder W1&#8211;2, AUD.</td><td>1 and 2</td></tr><tr><td>Any mental disorder W1&#8211;2 excluding specific phobias</td><td>Any mood disorder, Any anxiety disorder W1&#8211;2 excluding specific phobias, AUD.</td><td>1 and 2</td></tr><tr><td colspan="3"><i>Categories only presented in Supplementary table</i></td></tr><tr><td>Drug use disorder</td><td>Drug abuse, drug dependence.</td><td>1</td></tr><tr><td>Any substance use disorder</td><td>Drug use disorder, AUD.</td><td>1</td></tr><tr><td>Any disorder W1- supplement</td><td>Any mood disorder, Any anxiety disorder W1, Any substance use disorder</td><td>1</td></tr></table>
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<table><tr><td>Parameters</td><td>Value</td></tr><tr><td>Number of unigenes</td><td>68,961</td></tr><tr><td>Number of transcripts</td><td>134,793</td></tr><tr><td>Average unigene length (bp)</td><td>1322</td></tr><tr><td>Average transcript length (bp)</td><td>1600</td></tr><tr><td>Unigene N50 (bp)</td><td>1721</td></tr><tr><td>transcript N50 (bp)</td><td>2263</td></tr><tr><td>Minimum unigene length (bp)</td><td>201</td></tr><tr><td>Minimum transcript length (bp)</td><td>201</td></tr><tr><td>Maximum unigene length (bp)</td><td>15,890</td></tr><tr><td>Maximum transcript length (bp)</td><td>15,890</td></tr></table>
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<table><tr><td rowspan="2">Characteristic</td><td colspan="2">Univariate analysis</td><td colspan="2">Multivariate analysis</td></tr><tr><td>HR (95% CI)</td><td><i>P</i> value</td><td>HR (95% CI)</td><td><i>P</i> value</td></tr><tr><td>Age (&#8804; 40 vs. &gt; 40 years)</td><td>1.038 (0.614&#8211;1.752)</td><td>0.890</td><td>&#8211;</td><td></td></tr><tr><td>T stage (pT0&#8211;T1 vs. pT2-T4)</td><td>1.393 (0.897&#8211;2.164)</td><td>0.140</td><td>&#8211;</td><td></td></tr><tr><td>Family history of breast cancer (yes vs. no)</td><td>0.771 (0.386&#8211;1.543)</td><td>0.463</td><td>&#8211;</td><td></td></tr><tr><td>Axillary lymph node status (negative vs. positive)</td><td>2.507 (1.615&#8211;3.890)</td><td>&lt; 0.001</td><td>2.055 (1.190&#8211;3.547)</td><td>0.010</td></tr><tr><td>TNM stage (0-I vs. II-III)</td><td>2.063 (1.221&#8211;3.485)</td><td>0.007</td><td>1.237 (0.653&#8211;2.346)</td><td>0.514</td></tr><tr><td>Pathological type (invasive ductal carcinoma vs. others)</td><td>0.874 (0.450&#8211;1.695)</td><td>0.689</td><td>&#8211;</td><td></td></tr><tr><td>Vascular invasion (yes vs. no)</td><td>2.486 (1.497&#8211;4.126)</td><td>&lt; 0.001</td><td>1.901 (1.124&#8211;3.216)</td><td>0.017</td></tr><tr><td><i>ATG5</i> rs473543 genotype (AA/GA vs. GG)</td><td>1.717 (1.036&#8211;2.847)</td><td>0.036</td><td>1.729 (1.041&#8211;2.870)</td><td>0.034</td></tr></table>
3fe8d08c2ba98f1523dca19d0c9143c90bd30bbd8912ee1701f3528c5be2c558.png
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<table><tr><td>A</td><td>B</td><td>C</td><td>D</td><td>E</td><td>F</td><td>G</td><td>H</td><td>I</td><td>J</td><td>K</td></tr><tr><td>1</td><td>24</td><td>LD</td><td>Good</td><td>86</td><td>48 + 8</td><td>Screw track infection</td><td>12</td><td>90/85</td><td>Excellent</td><td>10&#8211;40</td></tr><tr><td>2</td><td>24</td><td>RS</td><td>Good</td><td>36</td><td>13 + 7</td><td>&#8211;</td><td>12</td><td>89/78</td><td>Excellent</td><td>15&#8211;50</td></tr><tr><td>3</td><td>24</td><td>Repair</td><td>Good</td><td>27</td><td>9 + 5</td><td>Superficial infection</td><td>6</td><td>91/80</td><td>Excellent</td><td>10&#8211;30</td></tr><tr><td>4</td><td>12</td><td>RS</td><td>Good</td><td>60</td><td>13 + 6</td><td>&#8211;</td><td>6</td><td>91/81</td><td>Good</td><td>5&#8211;20</td></tr><tr><td>5</td><td>24</td><td>RS</td><td>Good</td><td>97</td><td>8 + 7</td><td>&#8211;</td><td>9</td><td>89/80</td><td>Good</td><td>15&#8211;60</td></tr><tr><td>6</td><td>12</td><td>RS</td><td>Fair</td><td>62</td><td>44 + 5</td><td>Superficial infection</td><td>6</td><td>90/78</td><td>Good</td><td>5&#8211;30</td></tr><tr><td>7</td><td>24</td><td>Repair</td><td>Good</td><td>26</td><td>8 + 6</td><td>&#8211;</td><td>6</td><td>88/75</td><td>Excellent</td><td>15&#8211;50</td></tr><tr><td>8</td><td>24</td><td>RS</td><td>Good</td><td>28</td><td>10 + 9</td><td>&#8211;</td><td>6</td><td>87/77</td><td>Excellent</td><td>10&#8211;40</td></tr><tr><td>9</td><td>36</td><td>ALT</td><td>Good</td><td>83</td><td>36 + 7</td><td>&#8211;</td><td>12</td><td>94/77</td><td>Excellent</td><td>5&#8211;30</td></tr><tr><td>10</td><td>24</td><td>Repair</td><td>Good</td><td>32</td><td>22 + 8</td><td>&#8211;</td><td>6</td><td>90/80</td><td>Good</td><td>10&#8211;40</td></tr><tr><td>11</td><td>24</td><td>Repair</td><td>Good</td><td>27</td><td>21 + 8</td><td>Screw track infection</td><td>6</td><td>91/79</td><td>Good</td><td>20&#8211;50</td></tr><tr><td>12</td><td>12</td><td>Repair</td><td>Good</td><td>47</td><td>9 + 6</td><td>&#8211;</td><td>12</td><td>95/81</td><td>Good</td><td>10&#8211;30</td></tr><tr><td>13</td><td>12</td><td>Repair</td><td>Good</td><td>31</td><td>13 + 9</td><td>&#8211;</td><td>6</td><td>90/80</td><td>Good</td><td>10&#8211;40</td></tr><tr><td>14</td><td>24</td><td>LD</td><td>Good</td><td>54</td><td>26 + 7</td><td>&#8211;</td><td>6</td><td>93/80</td><td>Excellent</td><td>10&#8211;50</td></tr><tr><td>15</td><td>24</td><td>RS</td><td>Good</td><td>97</td><td>11 + 9</td><td>&#8211;</td><td>6</td><td>87/84</td><td>Good</td><td>10&#8211;40</td></tr><tr><td>16</td><td>12</td><td>Repair</td><td>Good</td><td>51</td><td>27 + 11</td><td>&#8211;</td><td>12</td><td>90/75</td><td>Good</td><td>10&#8211;20</td></tr></table>
65bc4b44c52e41b5429cfa47a5d20f38b8d50dc5f251105ad2a927a9f4e5e562.png
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<table><tr><td>Household assets</td><td>Yes</td><td>No</td></tr><tr><td>Electricity</td><td>120 (32%)</td><td>261 (69%)</td></tr><tr><td>Running water (tap)</td><td>39 (10%)</td><td>342 (90%)</td></tr><tr><td>Water closet toilet</td><td>65 (17%)</td><td>316 (83%)</td></tr><tr><td>Solar power</td><td>57 (15%)</td><td>324 (85%)</td></tr><tr><td>Television</td><td>181 (48%)</td><td>200 (53%)</td></tr><tr><td>Vehicle</td><td>95 (25%)</td><td>286 (75%)</td></tr><tr><td>Fridge</td><td>81 (22%)</td><td>300 (78%)</td></tr><tr><td>Indoor bathroom</td><td>93 (24%)</td><td>288 (76%)</td></tr><tr><td>Laundry machine</td><td>12 (3%)</td><td>369 (97%)</td></tr><tr><td>Computer</td><td>142 (37%)</td><td>239 (62%)</td></tr><tr><td>Micro wave oven</td><td>6 (2%)</td><td>375 (98%)</td></tr><tr><td>Fixed telephone</td><td>6 (2%)</td><td>375 (98%)</td></tr><tr><td>Mobile telephone</td><td>341 (90%)</td><td>40 (10%)</td></tr></table>
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<table><tr><td colspan="5">Patient characteristics</td></tr><tr><td><i>Mean age</i></td><td>Years 40.3</td><td>SD 16.4</td><td>Min 27.0</td><td>Max 55.0</td></tr><tr><td><i>Median length of stay</i></td><td>Years 5.5</td><td>SD 6.8</td><td>Min 0.5 yrs</td><td>Max 33.5 yrs</td></tr><tr><td><i>Ward location</i></td><td colspan="4"></td></tr><tr><td>Low secure hostel</td><td colspan="4">6 [12%]</td></tr><tr><td>Low secure rehabilitation ward</td><td colspan="4">11 [20%]</td></tr><tr><td>Medium security rehabilitation</td><td colspan="4">15 [29%]</td></tr><tr><td>Medium security sub-acute</td><td colspan="4">14 [27%]</td></tr><tr><td>High secure [long stay]</td><td colspan="4">6 [12%]</td></tr><tr><td><i>Community leave status</i></td><td colspan="4"></td></tr><tr><td>Community leave</td><td colspan="4">36 [70%]</td></tr><tr><td>No community Leave</td><td colspan="4">16 [30%]</td></tr><tr><td><i>Primary Diagnosis</i></td><td colspan="4"></td></tr><tr><td>Schizophrenia/ Schizoaffective disorder</td><td colspan="4">52 [100%]</td></tr></table>
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<table><tr><td></td><td>5 Fr Catheters (n = 49)</td><td>7 Fr Catheters (n = 48)</td><td><i>P</i></td></tr><tr><td>Total discomfort<sup>#1</sup></td><td>3.2 &#177; 0.2</td><td>3.9 &#177; 0.2</td><td>0.018</td></tr><tr><td>Difficulty with eating<sup>#1</sup></td><td>2.2 &#177; 0.1</td><td>2.7 &#177; 0.2</td><td>0.079</td></tr><tr><td>Nasal hemorrhage<sup>#2</sup></td><td>1 (2)</td><td>0 (0)</td><td>0.320</td></tr><tr><td>Sore throat<sup>#2</sup></td><td>6 (12)</td><td>9 (18)</td><td>0.376</td></tr><tr><td>Nausea<sup>#2</sup></td><td>0 (0)</td><td>1 (2)</td><td>0.310</td></tr><tr><td>Caught on a nearby object<sup>#2</sup></td><td>1 (2)</td><td>1 (2)</td><td>0.988</td></tr><tr><td>Other adverse events<sup>#2</sup></td><td>10 (20)</td><td>10 (20)</td><td>0.481</td></tr></table>
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<table><tr><td>Error number:Check the appropriate boxes</td><td>Physician assessment number: 1 or 2</td><td></td></tr><tr><td>Potential severity according to the Medication Error Index (3)</td><td></td><td></td></tr><tr><td>No consequences for the patient</td><td></td><td></td></tr><tr><td>An error avoided that would not cause patient harm</td><td></td><td></td></tr><tr><td>An error avoided that would require monitoring to confirm that it did not result in patient harm</td><td></td><td></td></tr><tr><td>Temporary damage</td><td>Potential clinical consequences</td><td>Potential hospitalisation and treatment*</td></tr><tr><td>An error avoided that could have contributed to temporary harm to the patient, requiring intervention</td><td>Acute renal failure</td><td>Hospitalisation</td></tr><tr><td></td><td>Cardiac toxicity</td><td>Prolongation of the initial hospitalisation</td></tr><tr><td></td><td>Skin toxicity</td><td>New hospitalisation</td></tr><tr><td>An error avoided that could have contributed to temporary harm to the patient, requiring initial or prolonged hospitalisation</td><td>Neutropenia</td><td>Type of ward</td></tr><tr><td></td><td>Thrombopenia</td><td>Standard hospitalisation unit</td></tr><tr><td></td><td>Anemia</td><td>Day-care unit</td></tr><tr><td></td><td>Febrile neutropenia</td><td>Intensive care unit</td></tr><tr><td></td><td>Neurotoxicity</td><td>Number of additional days of hospitalisation</td></tr><tr><td>Permanent damage</td><td>Hepatic cytolysis</td><td>Treatments</td></tr><tr><td>An error avoided that could have contributed to permanent patient harm</td><td>Hepatic cholestasis</td><td>Platelet transfusions</td></tr><tr><td>Compromised vital prognosis</td><td>Diarrhea</td><td>Erythrocyte transfusions</td></tr><tr><td>An error avoided that could have required intervention necessary to sustain life</td><td>Vomiting</td><td>Granulocyte Colony Stimulating Factor</td></tr><tr><td>Patient death</td><td>Other:</td><td>Parenteral nutrition</td></tr><tr><td></td><td></td><td>Other:</td></tr><tr><td>An error avoided that could have contributed to the patient's death</td><td></td><td></td></tr></table>
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<table><tr><td>Characteristics</td><td>Younger men without CAD (n = 25)</td><td>Older men without CAD (n = 25)</td><td>Younger men with CAD (n = 19)</td><td>Older men with CAD (n = 19)</td><td><i>P</i>-value</td><td>Adjusted <i>P</i>-value<sup>a</sup></td></tr><tr><td>Age (years)</td><td>53.6 &#177; 1.4</td><td>72.6 &#177; 1.5</td><td>54.3 &#177; 1.9</td><td>73.4 &#177; 1.9</td><td>&lt;0.001</td><td>-</td></tr><tr><td>BMI (kg/m<sup>2</sup>)</td><td>28.1 &#177; 1.1</td><td>27.0 &#177; 0.7</td><td>29.0 &#177; 1.2</td><td>26.3 &#177; 0.5</td><td>0.21</td><td>0.33</td></tr><tr><td>Waist circumference (cm)</td><td>100.4 &#177; 3.2</td><td>99.9 &#177; 1.7</td><td>102.2 &#177; 3.3</td><td>100.6 &#177; 1.7</td><td>0.94</td><td>0.81</td></tr><tr><td>Glucose (mmol/L)</td><td>5.12 &#177; 0.23</td><td>5.73 &#177; 0.20</td><td>6.00 &#177; 0.27</td><td>5.50 &#177; 0.20</td><td>0.06</td><td>0.06</td></tr><tr><td>Total cholesterol (mmol/L)</td><td>4.61 &#177; 0.20</td><td>3.78 &#177; 0.21</td><td>4.33 &#177; 0.30</td><td>3.91 &#177; 0.19</td><td>0.03</td><td>0.48</td></tr><tr><td>LDL-C (mmol/L)</td><td>2.58 &#177; 0.16</td><td>2.02 &#177; 0.17</td><td>2.67 &#177; 0.27</td><td>2.14 &#177; 0.16</td><td>0.04</td><td>0.63</td></tr><tr><td>HDL-C (mmol/L)</td><td>1.22 &#177; 0.08</td><td>1.16 &#177; 0.06</td><td>1.03 &#177; 0.05</td><td>1.12 &#177; 0.06</td><td>0.21</td><td>0.20</td></tr><tr><td>Fasting triglyceridemia (mmol/L)<sup>b</sup></td><td>1.58 &#177; 0.37</td><td>1.22 &#177; 0.14</td><td>1.48 &#177; 0.12</td><td>1.33 &#177; 0.11</td><td>0.27</td><td>0.79</td></tr><tr><td>Smoking (ever/never)</td><td>15/10</td><td>14/11</td><td>14/5</td><td>9/9</td><td>0.50</td><td>-</td></tr><tr><td>Medication (%)</td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>ARB</td><td>4 (16)</td><td>5 (20)</td><td>5 (26.3)</td><td>4 (21.1)</td><td>0.89</td><td>-</td></tr><tr><td>ASA</td><td>6 (24)</td><td>9 (36)</td><td>11 (57.9)</td><td>16 (84.2)</td><td>&lt;0.001</td><td>-</td></tr><tr><td>&#946;-Blocker</td><td>8 (32)</td><td>7 (28)</td><td>9 (47.4)</td><td>11 (57.9)</td><td>0.16</td><td>-</td></tr><tr><td>Diuretic</td><td>8 (32)</td><td>10 (40)</td><td>3 (15.8)</td><td>5 (26.3)</td><td>0.36</td><td>-</td></tr><tr><td>Calcium channel blocker</td><td>2 (8)</td><td>6 (24)</td><td>9 (47.4)</td><td>7 (36.8)</td><td>0.02</td><td>-</td></tr><tr><td>Lipid-lowering drugs</td><td>8 (32)</td><td>17 (68)</td><td>12 (63.2)</td><td>18 (94.7)</td><td>0.003</td><td>-</td></tr><tr><td>ACE inhibitors</td><td>11 (44)</td><td>8 (32)</td><td>8 (42.1)</td><td>6 (31.6)</td><td>0.75</td><td>-</td></tr><tr><td>Nitroglycerine</td><td>1 (4)</td><td>4 (16)</td><td>5 (26.3)</td><td>9 (47.4)</td><td>0.005</td><td>-</td></tr><tr><td>Mean <i>ABCA1</i> DNA methylation (%)</td><td>36.1 &#177; 1.5</td><td>35.9 &#177; 1.5</td><td>33.9 &#177; 1.3</td><td>40.7 &#177; 2.0<sup>c,d,e</sup></td><td>0.04</td><td>&lt;0.001</td></tr></table>
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<table><tr><td rowspan="2">Personal history of hiatal hernia</td><td rowspan="2">Family history of hiatal hernia</td><td> </td><td colspan="3">EA</td><td colspan="3">GCA</td><td colspan="3">DGA</td></tr><tr><td>Controls</td><td>Cases</td><td>OR (95% CI)<sup>a</sup></td><td><i>P</i><sup><i>a</i></sup></td><td>Cases</td><td>OR (95% CI)<sup>a</sup></td><td><i>P</i><sup><i>a</i></sup></td><td>Cases</td><td>OR (95% CI)<sup>a</sup></td><td><i>P</i><sup><i>a</i></sup></td></tr><tr><td>No</td><td>No</td><td>1117</td><td>93</td><td>1.00 (ref)</td><td> </td><td>129</td><td>1.00 (ref)</td><td> </td><td>249</td><td>1.00 (ref)</td><td> </td></tr><tr><td>No</td><td>Yes</td><td>68</td><td>6</td><td>1.26 (0.52-3.08)</td><td>0.61</td><td>13</td><td>1.89 (0.99-3.61)</td><td>0.056</td><td>8</td><td>0.89 (0.40-1.97)</td><td>0.77</td></tr><tr><td>Yes</td><td>No</td><td>82</td><td>36</td><td>4.91 (3.04-7.93)</td><td>&lt;0.001</td><td>23</td><td>2.36 (1.40-3.97)</td><td>0.001</td><td>17</td><td>1.44 (0.80-2.60)</td><td>0.22</td></tr><tr><td>Yes</td><td>Yes</td><td>12</td><td>10</td><td>10.75 (4.26-27.12)</td><td>&lt;0.001</td><td>9</td><td>6.55 (2.60-16.50)</td><td>&lt;0.001</td><td>2</td><td>-</td><td>-</td></tr><tr><td> </td><td> </td><td> </td><td> </td><td><i>P for interaction=</i></td><td><i>0.50</i></td><td> </td><td> </td><td><i>0.48</i></td><td> </td><td> </td><td><i>0.99</i></td></tr></table>
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<table><tr><td> </td><td>GG n = 146</td><td>GC/CC n = 64</td><td><i>p </i>value</td></tr><tr><td>Infection type</td><td> </td><td> </td><td> </td></tr><tr><td>Gram-negative</td><td>62%</td><td>81%</td><td>0.0062</td></tr><tr><td>Gram-positive</td><td>83%</td><td>83%</td><td>1.0000</td></tr><tr><td>Fungal</td><td>52%</td><td>58%</td><td>0.4565</td></tr><tr><td>Viral</td><td>18%</td><td>17%</td><td>1.0000</td></tr><tr><td>Parasitic</td><td>0%</td><td>0%</td><td> </td></tr><tr><td>Other</td><td>1%</td><td>3%</td><td> </td></tr></table>
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<table><tr><td>Stem cell source</td><td colspan="2">Benefits</td><td colspan="2">Drawbacks</td></tr><tr><td></td><td>Donor</td><td>Recipient</td><td>Donor</td><td>Recipient</td></tr><tr><td>BM</td><td></td><td>Lower risk of GvHD</td><td>More invasive HSC collection</td><td></td></tr><tr><td>PBSC</td><td>No general anesthesia for collection; less discomfort and pain</td><td>Faster hematopoietic engraftment and immune reconstitution; enhanced GvL effect</td><td></td><td>Higher risk of GvHD</td></tr><tr><td>CB</td><td>Non-invasive</td><td>Lower risks of GvHD and relapse; rapid availability; increased level of HLA-disparity tolerated</td><td></td><td>Lower number of HSCs; slower immune reconstitution</td></tr></table>
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<table><tr><td>Characteristic</td><td>Unit</td><td>Recommended values (Santos and Borem, 2013)</td><td>CTC20</td><td>CTC175-A</td></tr><tr><td>Fiber</td><td>% sugarcane</td><td>10&#8211;13</td><td>10.72</td><td>10.41</td></tr><tr><td>Starch</td><td>mg/kg</td><td>&lt;1,000</td><td>875</td><td>948</td></tr><tr><td>Brix</td><td>% juice</td><td>&gt;14</td><td>21.02</td><td>20.84</td></tr><tr><td>Dextran</td><td>mg/kg</td><td>&lt;10</td><td>&lt;10</td><td>&lt;10</td></tr><tr><td>RS</td><td>% juice</td><td>&lt;0.8</td><td>0.47</td><td>0.47</td></tr><tr><td>TRS</td><td>% juice</td><td>&gt;15</td><td>20.54</td><td>20</td></tr><tr><td>pH</td><td>&#8211;</td><td>4.8&#8211;5.8</td><td>5.4</td><td>5.3</td></tr><tr><td>Pol</td><td>% juice</td><td>&gt;14</td><td>19.43</td><td>19.26</td></tr><tr><td>Purity</td><td>% juice</td><td>&gt;85</td><td>92.44</td><td>92.42</td></tr></table>
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<table><tr><td colspan="2">CNE</td><td>Mt</td><td>Zt</td><td>Mg</td><td>Zg</td><td>Trans&amp;Gene</td><td>NoTrans&amp;Gene</td></tr><tr><td rowspan="2">Hs259</td><td>Limbs</td><td>+</td><td>-</td><td>+</td><td>-</td><td>Yes</td><td> </td></tr><tr><td>Spinal cord</td><td>-</td><td>+</td><td>+</td><td>+</td><td> </td><td> </td></tr><tr><td rowspan="4">Hs327</td><td>Hindbrain</td><td>+</td><td>+</td><td>+</td><td>+</td><td> </td><td> </td></tr><tr><td>Forebrain</td><td>-</td><td>+</td><td>+</td><td>+</td><td> </td><td> </td></tr><tr><td>Spinal cord</td><td>+</td><td>+</td><td>+</td><td>-</td><td> </td><td>Yes</td></tr><tr><td>Midbrain</td><td>-</td><td>+</td><td>+</td><td>+</td><td> </td><td> </td></tr><tr><td rowspan="8">Hs382</td><td>Forebrain</td><td>+</td><td>+</td><td>+</td><td>+</td><td> </td><td> </td></tr><tr><td>Somites</td><td>+</td><td>+</td><td>+</td><td>+</td><td> </td><td> </td></tr><tr><td>Spinal cord</td><td>+</td><td>-</td><td>+</td><td>+</td><td> </td><td> </td></tr><tr><td>DRG</td><td>+</td><td>-</td><td>+</td><td>-</td><td>Yes</td><td> </td></tr><tr><td>Eye</td><td>-</td><td>+</td><td>+</td><td>+</td><td> </td><td> </td></tr><tr><td>Notochord</td><td>-</td><td>+</td><td>+</td><td>+</td><td> </td><td> </td></tr><tr><td>Hindbrain</td><td>+</td><td>-</td><td>+</td><td>+</td><td> </td><td> </td></tr><tr><td>Midbrain</td><td>+</td><td>-</td><td>+</td><td>+</td><td> </td><td> </td></tr><tr><td rowspan="4">Hs422</td><td>Forebrain</td><td>+</td><td>+</td><td>+</td><td>+</td><td> </td><td> </td></tr><tr><td>Spinal cord</td><td>-</td><td>+</td><td>-</td><td>-</td><td> </td><td> </td></tr><tr><td>Nose</td><td>+</td><td>-</td><td>+</td><td>-</td><td>Yes</td><td> </td></tr><tr><td>Hindbrain</td><td>-</td><td>+</td><td>-</td><td>-</td><td> </td><td> </td></tr><tr><td rowspan="3">Hs595</td><td>Forebrain</td><td>+</td><td>+</td><td>+</td><td>+</td><td> </td><td> </td></tr><tr><td>Midbrain</td><td>+</td><td>-</td><td>+</td><td>+</td><td> </td><td> </td></tr><tr><td>Nose</td><td>+</td><td>-</td><td>+</td><td>-</td><td>Yes</td><td> </td></tr><tr><td rowspan="2">Hs609</td><td>Forebrain</td><td>+</td><td>-</td><td>+</td><td>+</td><td> </td><td> </td></tr><tr><td>Limbs</td><td>+</td><td>-</td><td>+</td><td>-</td><td>Yes</td><td> </td></tr><tr><td rowspan="4">Hs671</td><td>Forebrain</td><td>+</td><td>+</td><td>+</td><td>+</td><td> </td><td> </td></tr><tr><td>Eye</td><td>-</td><td>+</td><td>+</td><td>+</td><td> </td><td> </td></tr><tr><td>Hindbrain</td><td>-</td><td>+</td><td>+</td><td>+</td><td> </td><td> </td></tr><tr><td>DRG</td><td>-</td><td>+</td><td>+</td><td>-</td><td> </td><td> </td></tr><tr><td rowspan="3">Hs672</td><td>Forebrain</td><td>+</td><td>-</td><td>+</td><td>+</td><td> </td><td> </td></tr><tr><td>Midbrain</td><td>+</td><td>+</td><td>+</td><td>+</td><td> </td><td> </td></tr><tr><td>Spinal cord</td><td>+</td><td>-</td><td>+</td><td>-</td><td>Yes</td><td> </td></tr><tr><td rowspan="2">Hs687</td><td>Forebrain</td><td>+</td><td>+</td><td>+</td><td>+</td><td> </td><td> </td></tr><tr><td>Spinal cord</td><td>+</td><td>-</td><td>+</td><td>-</td><td>Yes</td><td> </td></tr><tr><td rowspan="4">Hs774</td><td>Hindbrain</td><td>+</td><td>+</td><td>+</td><td>+</td><td> </td><td> </td></tr><tr><td>Limbs</td><td>+</td><td>+</td><td>+</td><td>-</td><td> </td><td>Yes</td></tr><tr><td>Forebrain</td><td>-</td><td>+</td><td>+</td><td>+</td><td> </td><td> </td></tr><tr><td>Eye</td><td>-</td><td>+</td><td>-</td><td>+</td><td>Yes</td><td> </td></tr><tr><td rowspan="3">Hs1114</td><td>Midbrain</td><td>+</td><td>+</td><td>+</td><td>+</td><td> </td><td> </td></tr><tr><td>Hindbrain</td><td>+</td><td>+</td><td>-</td><td>+</td><td> </td><td> </td></tr><tr><td>Spinal cord</td><td>+</td><td>+</td><td>+</td><td>+</td><td> </td><td> </td></tr></table>
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<table><tr><td>ISAV Sample(s)</td><td>Sequence direction</td><td>No. of trimmed reads</td><td>Percent of reads identical to Sanger sequence</td></tr><tr><td>SCN1<sup>a</sup></td><td>HE gene forward</td><td>50552</td><td>82.4</td></tr><tr><td></td><td>HE gene reverse</td><td>69684</td><td>91.4</td></tr><tr><td></td><td>F gene forward</td><td>44498</td><td>91.9</td></tr><tr><td></td><td>F gene reverse</td><td>49118</td><td>89.2</td></tr><tr><td>SCN pool </td><td>HE gene forward</td><td>25695</td><td>78.3</td></tr><tr><td>(SCN2, SCN3, SCN4)</td><td>HE gene reverse</td><td>68481</td><td>92.2</td></tr><tr><td></td><td>F gene forward</td><td>31230</td><td>92.1</td></tr><tr><td></td><td>F gene reverse</td><td>35799</td><td>89.5</td></tr><tr><td>OBK1<sup>b</sup></td><td>HE gene forward</td><td>52038</td><td>92.4</td></tr><tr><td></td><td>HE gene reverse</td><td>88172</td><td>93.0</td></tr><tr><td></td><td>F gene forward</td><td>31546</td><td>91.4</td></tr><tr><td></td><td>F gene reverse</td><td>46835</td><td>89.7</td></tr><tr><td>OBK pool </td><td>HE gene forward</td><td>40458</td><td>92.1</td></tr><tr><td>(OBK2, OBK3, OBK4)</td><td>HE gene reverse</td><td>51772</td><td>92.8</td></tr><tr><td></td><td>F gene forward</td><td>45909</td><td>91.9</td></tr><tr><td></td><td>F gene reverse</td><td>44498</td><td>91.9</td></tr></table>
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<table><tr><td>Treatment</td><td>Total cells</td><td>Eosinophils</td><td>Monocytes</td><td>Lymphocytes</td><td>Neutrophils</td></tr><tr><td>PBS</td><td>240 &#177; 38&#167;</td><td>3 &#177; 1&#167;</td><td>201 &#177; 18</td><td>8 &#177; 5&#167;</td><td>10 &#177; 7</td></tr><tr><td>Dpt+Vit A 50</td><td>612 &#177; 36</td><td>293 &#177; 28</td><td>198 &#177; 24</td><td>86 &#177; 15</td><td>34 &#177; 8</td></tr><tr><td>Dpt+Vit A 500</td><td>624 &#177; 59</td><td>312 &#177; 29</td><td>199 &#177; 22</td><td>82 &#177; 12</td><td>29 &#177; 7</td></tr><tr><td>Dpt+Vit A 2500</td><td>428 &#177; 46</td><td>46 &#177; 35*</td><td>284 &#177; 34</td><td>79 &#177; 11</td><td>19 &#177; 7</td></tr></table>
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<table><tr><td>Duration (year)</td><td><i>n</i></td><td>%</td><td>Mean score</td><td>95%CI</td><td><i>t</i></td><td><i>p</i></td></tr><tr><td>&lt; 10</td><td>142</td><td>77</td><td>3.0</td><td>2.67&#8211;3.28</td><td>2.17</td><td>0.032</td></tr><tr><td>10&#8211;19</td><td>33</td><td>18</td><td>3.8</td><td>3.11&#8211;4.42</td><td></td><td></td></tr><tr><td>&#8805; 20</td><td>9</td><td>5</td><td>4.0</td><td>2.78&#8211;5.12</td><td>0.27</td><td>0.788</td></tr></table>
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<table><tr><td colspan="2"></td><td>Accurate Priced</td><td>Over Priced</td><td>Low Priced</td></tr><tr><td>Professional Year</td><td>N (%)</td><td>Median (Min-Max)</td><td>Median (Min-Max)</td><td>Median (Min-Max)</td></tr><tr><td>0-5</td><td>53 (35.57)</td><td>1 (0-6)</td><td>19 (8-28)</td><td>9 (1-20)</td></tr><tr><td>6-10</td><td>45 (30.20)</td><td>2 (0-5)</td><td>19 (9-27)</td><td>10 (2-20)</td></tr><tr><td>11-15</td><td>24 (16.10)</td><td>2 (0-6)</td><td>18.5 (11-26)</td><td>9.5 (3-14)</td></tr><tr><td>16-20</td><td>13 (8.72)</td><td>1 (0-3)</td><td>13 (2-25)</td><td>14 (5-27)*</td></tr><tr><td>&gt;20</td><td>14 (9.39)</td><td>1.5 (0-5)</td><td>18.5 (2-18)</td><td>9.5 (2-18)</td></tr><tr><td colspan="2">P</td><td>0.564</td><td>0.091</td><td>0.031</td></tr></table>
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<table><tr><td>Reporting criteria</td><td>CDE Programme</td></tr><tr><td>Where was the intervention delivered and why?</td><td>Primary care settings (GP surgeries) and community settings with a single lay educator (or with the use of interpreters when necessary</td></tr><tr><td>What behavioural change theory has intervention been based on (if any)?</td><td>Social learning theory</td></tr><tr><td>What behaviour change techniques were used by people delivering the intervention (if any)*?</td><td>1, 2, 4, 6, 8, 10, 19, 22, 24</td></tr><tr><td rowspan="3">A description of the activities and material provided in each workshop and their intended outcomes?</td><td>Material: information on weight management, choosing healthier foods, meal planning, physical exercise, checking and improving metabolic control and preventing complications.</td></tr><tr><td>Activities: participants taking each other&#8217;s blood pressure, BMI calculations, understanding sugar and salt content in foods, Eat-well plate, food maps, guided imagery, &#8216;freethink&#8217;.</td></tr><tr><td>Intended outcomes: desirable body weight, learn to shop for food, increase physical activity, take medication properly and regularly, recognise early symptoms of condition, regularly attend clinics, improved symptom control, reduced BMI, improved quality of life and knowledge of condition, reduced level of prescribing, slower disease progression, management of condition, carry out normal roles and activities, and manage emotional impact of illness.</td></tr><tr><td>What support (if any) was provided to individuals outside of workshops?</td><td>No contact outside of workshops.</td></tr><tr><td>Was a manual or protocol used to deliver the intervention and are there details on how it can be accessed?</td><td>Manual is available to lay educators, however, not used during intervention. Can be accessed via permission from Health Exchange.</td></tr><tr><td>How were individuals referred to the programme?</td><td>Patients suffering from diabetes mellitus, coronary heart disease and/or chronic kidney disease were invited to attend the programme. Patients referred to the programme by general practitioners, practice nurses or practice staff. Practices citing a lack of time asked CDEs to contact patients on chronic disease registers directly by phone or postal mail.</td></tr><tr><td>Were any cultural or structural adaptations used?</td><td>Delivery in various languages, cultural adaptation of educational material, application of visual aids and demonstrations, understandable terminology, emotional well-being, culturally sensitive approach to delivery, recruitment of lay personnel, delivery in community locations, and religious/cultural acknowledgement.</td></tr></table>
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complex
<table><tr><td></td><td colspan="2">Trial I</td><td colspan="2">Trial II</td></tr><tr><td></td><td>Filtered music</td><td>Headphones only condition</td><td>Filtered music</td><td>Unfiltered music</td></tr><tr><td></td><td>Mean age (SD)<sup>b</sup></td><td>Mean age (SD)<sup>b</sup></td><td>Mean age (SD)<sup>b</sup></td><td>Mean age (SD)<sup>b</sup></td></tr><tr><td>Met at least partial criteria on ADI-R<sup>a</sup></td><td></td><td></td><td></td><td></td></tr><tr><td> Male</td><td>58.24 (10.14), <i>n</i> = 25</td><td>49.46 (10.96), <i>n</i> = 23</td><td>54.89 (14.83), <i>n</i> = 44</td><td>56.20 (9.36), <i>n</i> = 27</td></tr><tr><td> Female<sup>c</sup></td><td>48.67 (11.99), <i>n</i> = 11</td><td>61.00 (7.91), <i>n</i> = 5</td><td>44 (20.66), <i>n</i> = 6</td><td>60.33 (9.29), <i>n</i> = 5</td></tr><tr><td>Total</td><td>55.37 (11.42), <i>n</i> = 36</td><td>52.67 (11.30), <i>n</i> = 28</td><td>53.33 (15.95), <i>n</i> = 50</td><td>56.74 (9.25), <i>n</i> = 32</td></tr></table>
afdf5cf2c7e2c397425a786859d5ed02c8a972de7082147cce0cb452be412bb6.png
complex
<table><tr><td rowspan="2">Fatty acids</td><td colspan="3">0.04 % CO<sub>2</sub></td><td colspan="3">2 % CO<sub>2</sub></td><td colspan="3">5 % CO<sub>2</sub></td></tr><tr><td>4th day</td><td>8th day</td><td>12th day</td><td>4th day</td><td>8th day</td><td>12th day</td><td>4th day</td><td>8th day</td><td>12th day</td></tr><tr><td>C16:0</td><td>23.92</td><td>24.69</td><td>24.00</td><td>20.94</td><td>16.63</td><td>14.54</td><td>19.28</td><td>16.63</td><td>12.54</td></tr><tr><td>C16:1</td><td>ND</td><td>ND</td><td>1.65</td><td>1.26</td><td>0.42</td><td>ND</td><td>1.92</td><td>0.42</td><td>ND</td></tr><tr><td>C16:2</td><td>6.10</td><td>7.33</td><td>7.50</td><td>4.41</td><td>1.44</td><td>0.71</td><td>4.09</td><td>2.04</td><td>0.91</td></tr><tr><td>C16:3</td><td>8.82</td><td>7.02</td><td>6.59</td><td>8.38</td><td>3.90</td><td>3.13</td><td>7.78</td><td>3.30</td><td>4.13</td></tr><tr><td>C18:0</td><td>3.21</td><td>2.47</td><td>2.11</td><td>1.00</td><td>2.22</td><td>2.16</td><td>1.42</td><td>2.02</td><td>2.16</td></tr><tr><td>C18:1</td><td>8.61</td><td>8.52</td><td>8.00</td><td>15.57</td><td>47.69</td><td>55.41</td><td>16.24</td><td>49.69</td><td>59.41</td></tr><tr><td>C18:2</td><td>23.29</td><td>24.73</td><td>26.89</td><td>21.18</td><td>13.00</td><td>11.00</td><td>21.85</td><td>11.00</td><td>10.23</td></tr><tr><td>C18:3</td><td>25.84</td><td>23.85</td><td>22.41</td><td>25.60</td><td>12.27</td><td>10.62</td><td>24.00</td><td>10.27</td><td>8.62</td></tr><tr><td>Others</td><td>0.32</td><td>1.42</td><td>0.85</td><td>1.66</td><td>2.42</td><td>2.43</td><td>3.41</td><td>4.62</td><td>2.00</td></tr></table>
51b27d65ab5377139f87c2282f1fa60ee702352c54ea2a8fefb6ef9654815365.png
complex
<table><tr><td></td><td colspan="2">Low utilization</td><td colspan="2">Intermediate utilization</td><td colspan="2">High utilization</td></tr><tr><td></td><td>Median</td><td>IQR</td><td>Median</td><td>IQR</td><td>Median</td><td>IQR</td></tr><tr><td>Volume measures (<i>n</i>)</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> Annual PICU admissions</td><td>1582</td><td>(977, 2602)</td><td>2283</td><td>(1678, 2657)</td><td>1614</td><td>(1475, 2241)<sup>NS</sup></td></tr><tr><td> Annual cardiac surgical volume</td><td>184</td><td>(116, 340)</td><td>233</td><td>(145, 314)</td><td>224</td><td>(180, 249)<sup>NS</sup></td></tr><tr><td colspan="7">PICU severity of illness measures (%)</td></tr><tr><td> Mechanical ventilation admits</td><td>36.8%</td><td>(26.9, 53.4)</td><td>43.9%</td><td>(37.5, 46.9)</td><td>36.9%</td><td>(31.3, 45.2)<sup>NS</sup></td></tr><tr><td> APR DRG SOI category 3</td><td>32.4%</td><td>(28.7, 34.3)</td><td>31.7%</td><td>(29.0, 33.7)</td><td>30.5%</td><td>(29.7, 34.0)<sup>NS</sup></td></tr><tr><td> APR DRG SOI category 4</td><td>20.3%</td><td>(15.2, 22.2)</td><td>24.2%</td><td>(17.4, 27.2)</td><td>20.7%</td><td>(19.1, 21.9)<sup>NS</sup></td></tr></table>
bdfb6ac6ba8557e3d735db78eedbdef62d837737f0552dd86cb298ba0e0d273f.png
complex
<table><tr><td rowspan="2">Measured variables</td><td>Pretest(<i>n</i> = 17)</td><td>Posttest(<i>n</i> = 17)</td><td rowspan="2">Test power</td><td rowspan="2">Effect size</td></tr><tr><td>Mean &#177; SD</td><td>Mean &#177; SD</td></tr><tr><td>SMMI</td><td>8.97 &#177; 1.69</td><td>10.52 &#177; 2.35</td><td>0.95</td><td>0.7529</td></tr><tr><td colspan="5">Physical fitness</td></tr><tr><td> Standing on one foot (seconds)</td><td>3.30 &#177; 7.19</td><td>7.36 &#177; 12.32</td><td>0.95</td><td>0.4023</td></tr><tr><td> Shoulder&#8211;arm flexibility (centimeters)</td><td>&#8722;37.50 &#177; 16.33</td><td>&#8722; 28.56 &#177; 13.94</td><td>0.95</td><td>0.5884</td></tr><tr><td> 8-ft up and go test (seconds)</td><td>36.2 &#177; 24.57</td><td>22.00 &#177; 17.25</td><td>0.95</td><td>&#8722;0.7091</td></tr><tr><td> Grip strength (kilograms)</td><td>11.19 &#177; 7.36</td><td>14.45 &#177; 7.48</td><td>0.95</td><td>0.4399</td></tr><tr><td> Five repeated sit-to-stand tests (seconds)</td><td>42.42 &#177; 22.98</td><td>30.58 &#177; 15.31</td><td>0.95</td><td>&#8722;0.6063</td></tr></table>
81f4b32310b824b224a882abd5ded36a8635c462936d69668647c7ce745b1268.png
simple
<table><tr><td></td><td>AF (<i>n</i> = 13)</td><td>nAF (<i>n</i> = 21)</td><td><i>p</i>-value</td></tr><tr><td>Gender (M/F)</td><td>9/4</td><td>15/6</td><td>0.716</td></tr><tr><td>Age (yrs)</td><td>64.6 &#177; 11.3</td><td>59.6 &#177; 12.1</td><td>0.237</td></tr><tr><td>BMI (kg/m<sup>2</sup>)</td><td>30.2 &#177; 6.14</td><td>27.5 &#177; 3.41</td><td>0.247</td></tr><tr><td>Height (m)</td><td>1.62 &#177; 0.19</td><td>1.67 &#177; 0.08</td><td>0.475</td></tr><tr><td>Weight (kg)</td><td>80.1 &#177; 3.86</td><td>77.7 &#177; 2.69</td><td>0.623</td></tr><tr><td>MI</td><td>33%</td><td>24%</td><td>0.555</td></tr><tr><td>Stroke</td><td>8.3%</td><td>14%</td><td>0.614</td></tr><tr><td>PVD</td><td>17%</td><td>4.8%</td><td>0.252</td></tr><tr><td>PCI</td><td>0.0%</td><td>0.0%</td><td>1.000</td></tr><tr><td>Hypertension</td><td>75%</td><td>76%</td><td>0.939</td></tr><tr><td>Hypercholesterolaemia</td><td>92%</td><td>90%</td><td>0.909</td></tr><tr><td>Family History</td><td>45%</td><td>65%</td><td>0.291</td></tr><tr><td>Diabetes<i>- On Insulin</i></td><td>58%<i>25%</i></td><td>43%<i>24%</i></td><td>0.392<i>0.939</i></td></tr><tr><td>Smoking</td><td>17%</td><td>24%</td><td>0.629</td></tr><tr><td>Alcohol &gt;10u per week</td><td>25%</td><td>25%</td><td>1.000</td></tr></table>
fae5739c75fe87ece1b4fcb7b781a89c9aa0091e10253357cb9e5a836db1757a.png
complex
<table><tr><td>Score of the reader</td><td>Sensitivity</td><td>Specificity</td><td>PPV</td><td>NPV</td></tr><tr><td colspan="5">CXR on all suspects (n = 998)</td></tr><tr><td>a) Highly consistent for TB</td><td>68 (64&#8211;72)</td><td>90 (87&#8211;93)</td><td>0.90 (0.87&#8211;0.93)</td><td>0.69 (0.65&#8211;0.72)</td></tr><tr><td>b) Consistent for TB</td><td>23 (19&#8211;26)</td><td>77 (73&#8211;80)</td><td>0.55 (0.49&#8211;0.62)</td><td>0.44 (0.40&#8211;0.47)</td></tr><tr><td>c) Pathology, but no TB</td><td>2 (0&#8211;3)</td><td>96 (94&#8211;98)</td><td>0.33 (0.16&#8211;0.51)</td><td>0.43 (0.40&#8211;0.46)</td></tr><tr><td><underline><i>"TB" (a+b)</i></underline></td><td>91 (88&#8211;93)</td><td>67 (62&#8211;71)</td><td>0.78 (0.74&#8211;0.81)</td><td>0.84 (0.81&#8211;.088)</td></tr><tr><td><underline><i>"any pathology" (a+b+c)</i></underline></td><td>92 (90&#8211;94)</td><td>63 (58&#8211;67)</td><td>0.76 (0.73&#8211;0.79)</td><td>0.86 (0.82&#8211;0.90)</td></tr><tr><td colspan="5">CXR on suspects excluding those who were ZN positive (n = 657)</td></tr><tr><td>a) Highly consistent for TB</td><td>48 (42&#8211;55)</td><td>90 (87&#8211;93)</td><td>0.72 (0.65&#8211;0.79)</td><td>0.77 (0.73&#8211;0.81)</td></tr><tr><td>b) Consistent for TB</td><td>31 (25&#8211;37)</td><td>77 (73&#8211;81)</td><td>0.42 (0.34&#8211;0.49)</td><td>0.68 (0.83&#8211;0.90)</td></tr><tr><td>c) Pathology but no TB</td><td>3 (1&#8211;5)</td><td>96 (95&#8211;98)</td><td>0.27 (0.9&#8211;0.46)</td><td>0.65 (0.62&#8211;0.69)</td></tr><tr><td><underline><i>"TB" (a+b)</i></underline></td><td>80 (74&#8211;85)</td><td>67 (62&#8211;71)</td><td>0.56 (0.50&#8211;0.61)</td><td>0.86 (0.83&#8211;0.90)</td></tr><tr><td colspan="5">The entire diagnostic process (n = 998)</td></tr><tr><td>ZN followed by CXR</td><td>93 (91&#8211;95)</td><td>62 (57&#8211;67)</td><td>0.76 (0.72&#8211;0.79)</td><td>0.87 (0.83&#8211;0.91)</td></tr><tr><td>CXR followed by ZN</td><td>89 (86&#8211;91)</td><td>97(84&#8211;90)</td><td>0.90 (0.87&#8211;0.92)</td><td>0.86 (0.83&#8211;0.89)</td></tr></table>
6a80a235299408dccdf546c59c73d78f4360f73d0041c2edbb5b49159761d0e8.png
complex
<table><tr><td></td><td colspan="2">Non-survey days </td><td colspan="2">Survey days </td><td colspan="3">Adjusted comparison<sup>a</sup></td></tr><tr><td>Number of consultations per day</td><td></td><td></td><td></td><td></td><td><i>Difference</i></td><td><i>95 % CI</i></td><td><i>p</i></td></tr><tr><td><i> Mean (SD)</i></td><td>11.9</td><td>(7.3)</td><td>14.1</td><td>(10.3)</td><td>2.03</td><td>1.20- 2.86</td><td>&lt;0.001</td></tr><tr><td><i> Median (IQR)</i></td><td>11</td><td>(7&#8211;16)</td><td>12</td><td>(8&#8211;17)</td><td></td><td></td><td></td></tr><tr><td>Missing MTUHA information</td><td><i>n</i></td><td><i>%</i></td><td><i>n</i></td><td><i>%</i></td><td><i>OR</i></td><td><i>95 % CI</i></td><td><i>p</i></td></tr><tr><td> Age</td><td>133</td><td>1.4 %</td><td>106</td><td>1.1 %</td><td>0.65</td><td>0.46-0.91</td><td>0.011</td></tr><tr><td> Gender</td><td>36</td><td>0.4 %</td><td>13</td><td>0.1 %</td><td>0.20<sup>b</sup></td><td>0.05-0.86<sup>b</sup></td><td>0.031<sup>b</sup></td></tr><tr><td> Village of origin</td><td>5,937</td><td>60.4 %</td><td>6,919</td><td>71.0 %</td><td>1.65<sup>c</sup></td><td>1.13-2.40<sup>c</sup></td><td>0.010<sup>c</sup></td></tr><tr><td> Previous attendance</td><td>1,604</td><td>16.3 %</td><td>2,127</td><td>21.8 %</td><td>0.54</td><td>0.26-1.13</td><td>0.103</td></tr><tr><td> Subscriber type</td><td>4,152</td><td>42.2 %</td><td>5,785</td><td>59.4 %</td><td>1.92<sup>c</sup></td><td>1.38-2.67<sup>c</sup></td><td>&lt;0.001<sup>c</sup></td></tr><tr><td>Malaria diagnostic and treatment (primary outcomes)</td><td><i>n/N</i></td><td><i>%</i></td><td><i>n/N</i></td><td><i>%</i></td><td><i>OR</i></td><td><i>95 % CI</i></td><td><i>p</i></td></tr><tr><td> RDT result recorded</td><td>1,811/9,834</td><td>18.4 %</td><td>2,010/9,745</td><td>20.6 %</td><td>1.11</td><td>0.98-1.26</td><td>0.097</td></tr><tr><td> AM prescription with a negative RDT</td><td>168/1,721</td><td>9.8 %</td><td>160/1,901</td><td>8.4 %</td><td>0.83</td><td>0.56-1.23</td><td>0.343</td></tr><tr><td> AM prescription without a RDT result</td><td>210/8,023</td><td>2.6 %</td><td>182/7,735</td><td>2.4 %</td><td>0.73</td><td>0.53-1.00</td><td>0.052</td></tr></table>
06f7a7f0419e3fcbd17cbc774b3c0e210d8fa5247523939dd5d46592bb178d92.png
complex
<table><tr><td rowspan="2">Honey source</td><td rowspan="2">Samples</td><td colspan="6">Parameters</td></tr><tr><td>pH</td><td>Moisture (%)</td><td>EC (mS/cm)</td><td>TDS (ppm)</td><td>Colour (nm)</td><td>ABS<sub>450</sub> (mAU,50w/v)</td></tr><tr><td rowspan="3"><i>Apis mellifera</i></td><td>I</td><td>4.46 &#177; 0.095</td><td>11.870 &#177; 0.703</td><td>0.163 &#177; 0.0153</td><td>264.1 &#177; 0.59</td><td>1.986 &#177; 0.001</td><td>961.33 &#177; 0.58</td></tr><tr><td>II</td><td>4.22 &#177; 0.077</td><td>11.537 &#177; 0.454</td><td>0.217 &#177; 0.1155</td><td>282.0 &#177; 0.25</td><td>2.102 &#177; 0.001</td><td>988.33 &#177; 1.15</td></tr><tr><td>III</td><td>4.04 &#177; 0.124</td><td>11.817 &#177; 0.301</td><td>0.240 &#177; 0.0200</td><td>316.3 &#177; 0.06</td><td>2.108 &#177; 0.001</td><td>1006.33 &#177; 1.53</td></tr><tr><td colspan="2">Mean</td><td><i>4.24</i> &#177; <i>0.20</i><sup><i>b</i></sup></td><td><i>11.74</i> &#177; <i>0.47</i><sup><i>a</i></sup></td><td><i>0.207</i> &#177; <i>0.04</i><sup><i>a</i></sup></td><td><i>287.46</i> &#177; <i>22.95</i><sup><i>b</i></sup></td><td><i>2.065</i> &#177; <i>0.06</i><sup><i>b</i></sup></td><td><i>985.33</i> &#177; <i>19.64</i><sup><i>c</i></sup></td></tr><tr><td rowspan="3"><i>Hypotrigona</i> sp.</td><td>I</td><td>3.85 &#177; 0.111</td><td>18.310 &#177; 0.900</td><td>0.317 &#177; 0.0058</td><td>399.1 &#177; 0.35</td><td>2.103 &#177; 0.001</td><td>724.33 &#177; 0.58</td></tr><tr><td>II</td><td>3.65 &#177; 0.036</td><td>17.053 &#177; 0.489</td><td>0.270 &#177; 0.0200</td><td>349.0 &#177; 0.36</td><td>1.861 &#177; 0.001</td><td>630.00 &#177; 1.73</td></tr><tr><td>III</td><td>3.75 &#177; 0.042</td><td>17.127 &#177; 0.239</td><td>0.323 &#177; 0.0493</td><td>362.0 &#177; 0.15</td><td>1.886 &#177; 0.001</td><td>682.67 &#177; 0.58</td></tr><tr><td colspan="2">Mean</td><td><i>3.75</i> &#177; <i>0.11</i><sup><i>a</i></sup></td><td><i>17.50</i> &#177; <i>0.80</i><sup><i>c</i></sup></td><td><i>0.303</i> &#177; <i>0.04</i><sup><i>b</i></sup></td><td><i>370.01</i> &#177; <i>22.51</i><sup><i>c</i></sup></td><td><i>1.950</i> &#177; <i>0.12</i><sup><i>b</i></sup></td><td><i>679.00</i> &#177; <i>40.95</i><sup><i>a</i></sup></td></tr><tr><td rowspan="3"><i>Melipona</i> sp.</td><td>I</td><td>3.80 &#177; 0.027</td><td>13.507 &#177; 0.047</td><td>0.217 &#177; 0.0152</td><td>209.0 &#177; 0.31</td><td>1.533 &#177; 0.000</td><td>762.33 &#177; 2.31</td></tr><tr><td>II</td><td>4.18 &#177; 0.066</td><td>15.203 &#177; 0.186</td><td>0.240 &#177; 0.0100</td><td>211.7 &#177; 0.15</td><td>2.012 &#177; 0.001</td><td>792.33 &#177; 1.15</td></tr><tr><td>III</td><td>4.65 &#177; 0.053</td><td>12.863 &#177; 0.221</td><td>0.257 &#177; 0.0153</td><td>221.2 &#177; 0.15</td><td>1.632 &#177; 0.001</td><td>805.33 &#177; 0.58</td></tr><tr><td colspan="2">Mean</td><td><i>4.21</i> &#177; <i>0.37</i><sup><i>b</i></sup></td><td><i>13.86</i> &#177; <i>1.06</i><sup><i>b</i></sup></td><td><i>0.238</i> &#177; <i>0.02</i><sup><i>a</i></sup></td><td><i>214.00</i> &#177; <i>5.55</i><sup><i>a</i></sup></td><td><i>1.726</i> &#177; <i>0.22</i><sup><i>a</i></sup></td><td><i>786.67</i> &#177; <i>19.14</i><sup><i>b</i></sup></td></tr></table>
1081b1728969e56931dec3b2bdd2385e759d58dca118f5696b596925f5560c05.png
complex
<table><tr><td></td><td colspan="3">Pathogen</td><td colspan="3">Host</td></tr><tr><td>Measure (<i>n</i>)</td><td>Among regions</td><td>Among populations</td><td>Within populations</td><td>Among regions</td><td>Among populations</td><td>Within populations</td></tr><tr><td>Infectivity (<i>n</i> &gt; 840)</td><td>0.000</td><td>0.026</td><td>0.450</td><td>0.000</td><td>0.032</td><td>0.492</td></tr><tr><td>Time to sporulation (<i>n</i> &gt; 532)</td><td>0.000</td><td>0.000</td><td>0.255</td><td>0.000</td><td>0.002</td><td>0.052</td></tr><tr><td>Aggressiveness (<i>n</i> &gt; 527)</td><td>0.000</td><td>0.000</td><td>0.202</td><td>0.000</td><td>0.000</td><td>0.065</td></tr><tr><td>Colony size (<i>n</i> &gt; 527)</td><td>0.000</td><td>0.008</td><td>0.137</td><td>0.000</td><td>0.000</td><td>0.058</td></tr><tr><td>Fitness 1 (<i>n</i> &gt; 527)</td><td>0.000</td><td>0.000</td><td>0.240</td><td>0.000</td><td>0.000</td><td>0.090</td></tr><tr><td>Fitness 2 (<i>n</i> &gt; 527)</td><td>0.000</td><td>0.000</td><td>0.254</td><td>0.000</td><td>0.000</td><td>0.092</td></tr><tr><td>Sexual spore production (<i>n</i> &gt; 291)</td><td>0.000</td><td>0.232</td><td>0.663</td><td>0.001</td><td>0.000</td><td>0.105</td></tr></table>
c7cca03dd7697167ed61080609d02d6cd7d1a4e4ab8b73cfdcd3f9c92464511f.png
simple
<table><tr><td>Scenario</td><td>Deaths per 1,000 live births in 2010 (95% CI)</td><td>Annualized rate of decline, 1990&#8211;2010 (95% CI)</td></tr><tr><td>Currently estimated values</td><td>111 (108, 115)</td><td>2.2% (2.0&#8211;2.4%)</td></tr><tr><td>Counterfactual at 2005 coverage levels</td><td>119 (114, 123)</td><td>1.9% (1.7&#8211;2.1%)</td></tr><tr><td>Counterfactual at 2000 coverage levels</td><td>124 (118, 129)</td><td>1.7% (1.5&#8211;1.9%)</td></tr></table>
8d3c4cc82b63baadb22e759047d8cef854bf1ec26a4a0a13b3cce35c0c3ea4b7.png
simple
<table><tr><td>GO-ID</td><td>Term</td><td>Category<sup>a</sup></td><td>FDR<sup>b</sup></td><td>P-Value</td><td>#Test</td><td>#Ref</td><td>#notAnnot Test</td><td>#notAnnot Ref</td></tr><tr><td>GO:0005506</td><td>iron ion binding</td><td>F</td><td>3.99E-07</td><td>9.40E-11</td><td>17</td><td>153</td><td>115</td><td>9554</td></tr><tr><td>GO:0055114</td><td>oxidation-reduction process</td><td>P</td><td>1.09E-06</td><td>6.16E-10</td><td>31</td><td>636</td><td>101</td><td>9071</td></tr><tr><td>GO:0016491</td><td>oxidoreductase activity</td><td>F</td><td>1.09E-06</td><td>7.68E-10</td><td>31</td><td>642</td><td>101</td><td>9065</td></tr><tr><td>GO:0004497</td><td>monooxygenase activity</td><td>F</td><td>6.16E-06</td><td>5.87E-09</td><td>13</td><td>106</td><td>119</td><td>9601</td></tr><tr><td>GO:0020037</td><td>heme binding</td><td>F</td><td>6.16E-06</td><td>8.61E-09</td><td>15</td><td>157</td><td>117</td><td>9550</td></tr><tr><td>GO:0046906</td><td>tetrapyrrole binding</td><td>F</td><td>6.16E-06</td><td>9.33E-09</td><td>15</td><td>158</td><td>117</td><td>9549</td></tr><tr><td>GO:0044710</td><td>single-organism metabolic process</td><td>P</td><td>6.16E-06</td><td>1.02E-08</td><td>52</td><td>1747</td><td>80</td><td>7960</td></tr><tr><td>GO:0016705</td><td>oxidoreductase activity, acting on paired donors, with incorporation</td><td>F</td><td></td><td></td><td></td><td></td><td>117</td><td>9534</td></tr><tr><td></td><td>or reduction of molecular oxygen</td><td></td><td>1.53E-05</td><td>2.88E-08</td><td>15</td><td>173</td><td></td><td></td></tr><tr><td>GO:0003824</td><td>catalytic activity</td><td>F</td><td>5.33E-03</td><td>1.13E-05</td><td>75</td><td>3644</td><td>57</td><td>6063</td></tr></table>
fe65cea3f1d24a25e817e8dec82a71a2115710460a8c6af72b2a890295833462.png
simple
<table><tr><td>Gingival index</td><td>Number of patients</td></tr><tr><td>0</td><td>23</td></tr><tr><td>1</td><td>55</td></tr><tr><td>2</td><td>16</td></tr><tr><td>3</td><td>14</td></tr><tr><td>Total</td><td>108</td></tr></table>
08f74de06753bc9710c9f37ac30bc515e321097ec57179a2e016a50dabeb6d93.png
simple
<table><tr><td>Peptide</td><td>Sequence</td><td>Portal vein (nM/h)</td><td>Jugular vein (nM/h)</td><td>CL Rat (mL/min/Kg)</td><td>Liver first pass effect (%)</td></tr><tr><td>(4)</td><td>[Abu-Leu-NMe-D-Leu-NMe-Leu-Leu-D-Pro]</td><td>1839</td><td>1656</td><td>41</td><td>11</td></tr><tr><td>(5)</td><td>[Ala-Leu-NMe-D-Leu-NMe-Leu-Leu-D-Pro]</td><td>449</td><td>104</td><td>70</td><td>77</td></tr></table>
2d8019acc4f4816b0b042fa7491ceec07d7340db04a8cb8f4ff4ab73323b37ee.png
simple
<table><tr><td>Group</td><td>0 month</td><td>6 months</td><td>12 months</td><td>18 months</td><td>24 months</td><td>30 months</td><td>36 months</td></tr><tr><td>O</td><td>31.33 &#177; 4.62</td><td>31.61 &#177; 4.47</td><td>32.83 &#177; 4.69</td><td>34.11 &#177; 4.85</td><td>35.69 &#177; 5.01</td><td>37.92 &#177; 4.94</td><td>40.67 &#177; 5.08</td></tr><tr><td>M</td><td>32.4 &#177; 3.92</td><td>33.13 &#177; 4.49</td><td>34.53 &#177; 4.53</td><td>36.33 &#177; 4.7</td><td>38.4 &#177; 4.75</td><td>40.67 &#177; 4.37</td><td>43.33 &#177; 3.22</td></tr><tr><td>O + B + C<sup>*</sup></td><td>30.38 &#177; 6.02</td><td>31.67 &#177; 6.12</td><td>33.46 &#177; 5.93</td><td>36.04 &#177; 5.76</td><td>38.96 &#177; 5.69</td><td>41.96 &#177; 4.65</td><td>44.83 &#177; 3.71</td></tr><tr><td>O + B</td><td>31.83 &#177; 5.84</td><td>33.58 &#177; 5.42</td><td>35.75 &#177; 4.59</td><td>38.83 &#177; 3.64</td><td>43.17 &#177; 2.08</td><td>46.58 &#177; 1.16</td><td>47.42 &#177; 0.79</td></tr></table>
5514d8c672aabc4338e3bd300af8a4a96352771ba2dc86ae22aa5b30b3aab90f.png
simple
<table><tr><td>Postal</td><td>Electronic</td></tr><tr><td>Monetary or non-monetary incentives</td><td>Non-monetary incentives</td></tr><tr><td>Teaser on the envelope</td><td>Personalised questionnaires</td></tr><tr><td>Pre-notification</td><td>Include pictures</td></tr><tr><td>Follow-up with another copy included</td><td>Not including &#8216;survey&#8217; in subject line</td></tr><tr><td>Handwritten addresses</td><td>Male signature</td></tr><tr><td>University sponsorship</td><td>White background</td></tr><tr><td>Use recorded delivery</td><td>Short questionnaire</td></tr><tr><td>Include return envelope</td><td>Offer of results</td></tr><tr><td>Avoid sensitive questions</td><td>Statement that others have responded</td></tr></table>
be0a551330c96497f4265cbf6610bc8e52df21364663f5171b9181aa4ec9a738.png
simple
<table><tr><td></td><td>Control</td><td>iStroke</td><td><i>P</i></td></tr><tr><td>Time, minutes, mean &#177; SD</td><td>14.6 &#177; 7.4</td><td>7.3 &#177; 5.2</td><td>0.010</td></tr><tr><td>Total missed contraindication counts, n (%<sup>a</sup>)</td><td>23 (42.6)</td><td>7 (13.0)</td><td>0.001</td></tr><tr><td>Missed contraindication counts per physician</td><td></td><td></td><td></td></tr><tr><td> Mean &#177; SD</td><td>1.9 &#177; 0.7</td><td>0.6 &#177; 1.0</td><td>0.001</td></tr><tr><td> Median</td><td>2.0</td><td>0</td><td>0.002</td></tr><tr><td>Missed contraindication counts per item</td><td></td><td></td><td></td></tr><tr><td> Mean &#177; SD</td><td>3.8 &#177; 2.5</td><td>1.2 &#177; 1.5</td><td>0.047</td></tr><tr><td> Median</td><td>3.5</td><td>1.0</td><td>0.027</td></tr></table>
67141ad51171d99e29df1517838051acd58632bb2af36002305cc2c1b0983f79.png
complex
<table><tr><td>Mutation</td><td>Score</td><td>Confidence</td><td>Domain</td><td>Prediction</td></tr><tr><td rowspan="2">R61W</td><td rowspan="2">0.773</td><td>Sensitivity: 0.76</td><td rowspan="2">EGF-like 1</td><td rowspan="2">Possibly damaging</td></tr><tr><td>Especificity: 0.86</td></tr><tr><td rowspan="2">R75P</td><td rowspan="2">0.884</td><td>Sensitivity: 0.71</td><td rowspan="2">EGF-like 1</td><td rowspan="2">Possibly damaging</td></tr><tr><td>Especificity: 0.89</td></tr><tr><td rowspan="2">D80G</td><td rowspan="2">0.694</td><td>Sensitivity: 0.78</td><td rowspan="2">EGF-like 2</td><td rowspan="2">Possibly damaging</td></tr><tr><td>Especificity: 0.85</td></tr><tr><td rowspan="2">R213K</td><td rowspan="2">0.171</td><td>Sensitivity: 0.89</td><td rowspan="2">EGF-like 5</td><td rowspan="2">Benign</td></tr><tr><td>Especificity: 0.72</td></tr></table>
7811b8a215f97c7b47e7da44829b6e3139275b17a89d3c646685d8c4f85da601.png
simple
<table><tr><td>Source</td><td>Df</td><td>F</td></tr><tr><td>Species</td><td>8</td><td>24.6***</td></tr><tr><td>Water Level</td><td>1</td><td>13.3***</td></tr><tr><td>Species* Water</td><td>8</td><td>1.2</td></tr></table>
b95d5362f880e73d9bdc2c151418a38a9787a3bc5dc102578f80a26702c1cba7.png
simple
<table><tr><td>Age of spores</td><td>Mean spore diameter/radius (&#956;m)</td><td>Spore volume (mm<sup>3</sup>)</td><td>Viability (%)</td><td>Germination (%)</td></tr><tr><td>14 days</td><td>30.4/15.2</td><td>0.000015</td><td>90</td><td>0</td></tr><tr><td>30 days</td><td>64.2/32.1</td><td>0.000139</td><td>90</td><td>40</td></tr><tr><td>60 days</td><td>96/48</td><td>0.00046</td><td>90</td><td>38</td></tr><tr><td>90 days</td><td>105.7/52.8</td><td>0.00061</td><td>95</td><td>50</td></tr></table>
88cd952413c692bb468f64098c4960834359866263b064f55b65528b0c186e14.png
simple
<table><tr><td>Bacterial strains/Plasmids</td><td>Characteristic</td><td>Source/Reference</td></tr><tr><td><i>Brucella ovis</i></td><td> </td><td> </td></tr><tr><td>PA</td><td>virulent strain, natural Nal<sup>R</sup></td><td>CITA collection</td></tr><tr><td>Bo&#916;<i>wadA</i></td><td>PA in frame deletion mutant in <i>wadA</i> &#916;58-679</td><td>This work</td></tr><tr><td>Bo&#916;<i>wadB</i></td><td>PA in frame deletion mutant in <i>wadB</i> &#916;49-195</td><td>This work</td></tr><tr><td>Bo&#916;<i>wadC</i></td><td>PA in frame deletion mutant in <i>wadC</i> &#916;17-306</td><td>This work</td></tr><tr><td>BoPA-Gm</td><td>challenge strain, PA Gm<sup>R</sup></td><td>UN collection</td></tr><tr><td><i>Brucella melitensis</i></td><td> </td><td> </td></tr><tr><td>Rev 1</td><td>reference vaccine</td><td>CITA collection</td></tr><tr><td><i>E. coli</i></td><td> </td><td> </td></tr><tr><td>S17-1 &#955;pir</td><td>mating strain with plasmid RP4 inserted into the chromosome</td><td>Simon et al. [[19]]</td></tr><tr><td>TOP10 F&#8217;</td><td>F<sup>&#8722;</sup><i>lacI</i>q Tn <i>10</i> (Tet<sup>R</sup>) mcrA &#916;(<i>mrr-hsdRMS-mcrBC</i>) 80<i>lacZ</i> &#916;M15 &#916;<i>lacX74 recA1alaD139 endA1 nupG</i></td><td>Invitrogen</td></tr><tr><td>Plasmids</td><td> </td><td> </td></tr><tr><td>pCR2.1</td><td>cloning vector</td><td>Invitrogen</td></tr><tr><td>pJQK</td><td>derivated of pJQ200KS+; Km<sup>R</sup>, Gm<sup>S</sup></td><td>Scupham and Triplett [[20]]</td></tr><tr><td>pYRI-12</td><td>913-bp of <i>B. abortus</i> parental chromosomal DNA containing the <i>wadA</i> deletion allele, generated by PCR and cloned into pCR2.1</td><td>This work</td></tr><tr><td>pYRI-13</td><td><i>BamHI-XbaI</i> fragment from pYRI-12 cloned into the corresponding sites of pJQK</td><td>This work</td></tr><tr><td>pYRI-1</td><td>570-bp of <i>B. abortus</i> parental chromosomal DNA containing the <i>wadB</i> deletion allele, generated by PCR and cloned into pCR2.1</td><td>Gil-Rami&#769;rez et al. [[7]]</td></tr><tr><td>pYRI-2</td><td><i>BamHI-XbaI</i> fragment from pYRI-1 cloned into the corresponding sites of pJQK</td><td>Gil-Rami&#769;rez et al. [[7]]</td></tr><tr><td>pYRI-14</td><td>934-bp of <i>B. ovis</i> parental chromosomal DNA containing the <i>wadC</i> deletion allele, generated by PCR and cloned into pCR2.1</td><td>This work</td></tr><tr><td>pYRI-15</td><td>BamHI-XbaI fragment from pYRI-14 cloned into the corresponding sites of pJQK</td><td>This work</td></tr></table>
ccdc46420508c939bad5181e7f5aaba2b699ee76848ff99e00e7b5bad5961681.png
complex
<table><tr><td>Age</td><td colspan="2">P0&#8211;P1<i><sup>a</sup></i></td><td colspan="2">P10</td><td colspan="2">P21</td></tr><tr><td><i>Dnaaf1<sup>m4Bei</sup></i></td><td>Observed<i><sup>b</sup></i></td><td>Expected</td><td>Observed<i><sup>c</sup></i></td><td>Expected</td><td>Observed<i><sup>d</sup></i></td><td>Expected</td></tr><tr><td> Wild-type</td><td>29</td><td>20.5</td><td>21</td><td>17.5</td><td>12</td><td>8.25</td></tr><tr><td> Heterozygote</td><td>39</td><td>41</td><td>43</td><td>35</td><td>21</td><td>16.5</td></tr><tr><td> Homozygote</td><td>14</td><td>20.5</td><td>6</td><td>17.5</td><td>0</td><td>8.25</td></tr><tr><td>Laterality defect</td><td>8 (57.1%)</td><td></td><td>2 (33.3%)</td><td></td><td>N/A<i><sup>e</sup></i></td><td></td></tr><tr><td><i> Situs inversus</i></td><td>3</td><td></td><td>0</td><td></td><td></td><td></td></tr><tr><td> Heterotaxy</td><td>5</td><td></td><td>2</td><td></td><td></td><td></td></tr><tr><td><i>Lrrc48<sup>m6Bei</sup></i></td><td>Observed</td><td>Expected</td><td>Observed</td><td>Expected</td><td>Observed</td><td>Expected</td></tr><tr><td> Wild-type</td><td>21</td><td>18</td><td>24</td><td>19.75</td><td>22</td><td>17.75</td></tr><tr><td> Heterozygote</td><td>33</td><td>36</td><td>36</td><td>39.5</td><td>31</td><td>35.5</td></tr><tr><td> Homozygote</td><td>18</td><td>18</td><td>19</td><td>19.75</td><td>18</td><td>17.75</td></tr><tr><td>Laterality defect</td><td>2 (11.1%)</td><td></td><td>1 (5.3%)</td><td></td><td>N/A<i><sup>e</sup></i></td><td></td></tr><tr><td><i> Situs inversus</i></td><td>2</td><td></td><td>0</td><td></td><td></td><td></td></tr><tr><td> Heterotaxy</td><td>0</td><td></td><td>1</td><td></td><td></td><td></td></tr></table>
1d7c496bc76633ccaf662f095fb7c11c869409b810510c659e3ddd45f9d80dd2.png
simple
<table><tr><td>Cell type</td><td>Stimulation</td><td>Type of HA binding</td><td>HA receptor</td><td>Reference</td></tr><tr><td>Monocyte (human)</td><td>TNF&#945;, LPS, IL-1, IFN-&#947;</td><td>Inducible</td><td>CD44</td><td>(59&#8211;61)</td></tr><tr><td>Alveolar macrophages (human, rodents)</td><td>None</td><td>Constitutive</td><td>CD44</td><td>(17, 46 &#8211;48, 50)</td></tr><tr><td>Peritoneal macrophage (mouse)</td><td>LPS with IFN&#947;, or IL-4</td><td>Inducible</td><td>CD44</td><td>(62)</td></tr><tr><td>Bone marrow-derived macrophages (mouse)</td><td>LPS with IFN&#947;, TNF&#945;, or IL-4</td><td>Inducible</td><td>CD44</td><td>(62)</td></tr><tr><td>Monocyte-derived DC (human)</td><td>CD40L expressing fibroblasts</td><td>Inducible</td><td>CD44</td><td>(63)</td></tr><tr><td>B cells (human, mouse)</td><td>PMA, IL-5, LPS</td><td>Inducible, a subset binds</td><td>CD44</td><td>(64 &#8211;67)</td></tr><tr><td>T cells (mouse)</td><td>PMA/ionomycin, CD3 antibodies, specific antigen, or superantigen</td><td>Inducible, often a subset binds</td><td>CD44</td><td>(54, 55, 68)</td></tr><tr><td>CD4+ CD25+ T regulatory cells (human and mouse)</td><td>CD3 +/&#8722; CD28 activation</td><td>Inducible, a subset binds</td><td>CD44</td><td>(69, 70)</td></tr><tr><td>Neutrophil (mouse)</td><td>LPS induced liver inflammation <i>in vivo</i></td><td>Binding to SHAP modified HA</td><td>CD44, not RHAMM</td><td>(71)</td></tr><tr><td>NK cells (mouse)</td><td>IL-2, IL-15</td><td>Inducible, a subset binds</td><td>CD44</td><td>(72)</td></tr><tr><td>Platelets (mouse)</td><td>None</td><td>Constitutive</td><td>CD44</td><td>(73)</td></tr></table>
ad8b209de27a324efe17f4c6b75b40be648e835138ac05884de2f3234095ed78.png
simple
<table><tr><td>Compound</td><td>Elution time (min)</td><td>Fraction theoretically contained in</td></tr><tr><td>Phenylalanine</td><td>5.964 &#177; 0.003</td><td>B</td></tr><tr><td>Caffeic acid</td><td>13.471 &#177; 0.170</td><td>C</td></tr><tr><td>Coumaric acid</td><td>15.941 &#177; 0.208</td><td>D</td></tr><tr><td>Vanillin</td><td>16.187 &#177; 0.065</td><td>D</td></tr><tr><td>Cinnamic acid</td><td>23.595 &#177; 0.155</td><td>E</td></tr><tr><td>Capsaicin</td><td>32.801 &#177; 0.053</td><td>G</td></tr></table>
458615082c1ab06f250ec8ce00c8cec0b9e9cae9ebc35f5b3e9d68eb52c13b40.png
complex
<table><tr><td colspan="2">Group Variables </td><td>With iron deficiency</td><td>Without iron deficiency</td><td>P-value</td></tr><tr><td rowspan="2">Type of febrile seizure </td><td>Simple</td><td>12(37.5%)</td><td>20(62.5%)</td><td rowspan="2">0.04</td></tr><tr><td>Complex </td><td>12(66.7%)</td><td>6(33.3%)</td></tr></table>
b9b669056f8ef5e243f051058bedf13f916e1affa2b614bc902f9df7cbd9f9e2.png
complex
<table><tr><td>Characteristics of the Patients at Baseline</td><td>Total population (<i>n</i> = 257)</td><td>SR-group (n = 148)</td><td>AF-group (n = 109)</td><td><i>p</i> Value</td></tr><tr><td>Age &#8212; yr</td><td>80.8 &#177; 6.0</td><td>80.6 &#177; 6.0</td><td>80.9 &#177; 6.0</td><td>0.736</td></tr><tr><td>Male sex &#8212; no. (%)</td><td>118 (45.9%)</td><td>62 (41.9%)</td><td>56 (51.4%)</td><td>0.163</td></tr><tr><td>Body-mass index (kg/m<sup>2</sup>)</td><td>28.2 &#177; 5.5</td><td>28.3 &#177; 5.6</td><td>28.1 &#177; 5.3</td><td>0.724</td></tr><tr><td>Diabetes mellitus (n. %)</td><td>110 (42.8%)</td><td>57 (38.5%)</td><td>53 (48.6%)</td><td>0.126</td></tr><tr><td>Diabetes treated with insulin</td><td>68 (26.5%)</td><td>33 (22.3%)</td><td>35 (32.1%)</td><td>0.087</td></tr><tr><td>Hypertension</td><td>223 (86.8%)</td><td>126 (85.1%)</td><td>97 (89.0%)</td><td>0.457</td></tr><tr><td>Dyslipidemia (n. %)</td><td>179 (69.6%)</td><td>102 (68.9%)</td><td>77 (70.6%)</td><td>0.785</td></tr><tr><td>PAD</td><td>40 (15.6%)</td><td>17 (11.5%)</td><td>23 (21.1%)</td><td>0.038</td></tr><tr><td>Chronic obstructive pulmonary disease (n %)</td><td>50 (19.5%)</td><td>33 (22.3%)</td><td>17 (15.6%)</td><td>0.204</td></tr><tr><td colspan="5">Medical history &#8212; no. (%)</td></tr><tr><td>Chronic kidney disease on dialysis</td><td>8 (3.1%)</td><td>7 (4.7%)</td><td>1 (0.9%)</td><td>0.143</td></tr><tr><td>History of cancer</td><td>64 (24.9%)</td><td>40 (27.0%)</td><td>24 (22.0%)</td><td>0.384</td></tr><tr><td>Active cancer</td><td>20 (7.8%)</td><td>10 (6.8%)</td><td>10 (9.2%)</td><td>0.489</td></tr><tr><td>Coronary heart disease</td><td>210 (81.7%)</td><td>120 (81.1%)</td><td>90 (82.6%)</td><td>0.871</td></tr><tr><td>Coronary-artery bypass surgery</td><td>36 (14.0%)</td><td>18 (12.2%)</td><td>18 (16.5%)</td><td>0.365</td></tr><tr><td>Myocardial infarction</td><td>30 (11.7%)</td><td>15 (10.1%)</td><td>15 (13.8%)</td><td>0.433</td></tr><tr><td>PCI</td><td>67 (26.1%)</td><td>42 (28.4%)</td><td>25 (22.9%)</td><td>0.389</td></tr><tr><td>Pacemaker</td><td>32 (12.5%)</td><td>11 (7.4%)</td><td>21 (19.3%)</td><td>0.007</td></tr><tr><td>Stroke</td><td>40 (15.6%)</td><td>22 (14.9%)</td><td>18 (16.5%)</td><td>0.731</td></tr><tr><td>NYHA III</td><td>164 (63.8%)</td><td>96 (64.9%)</td><td>68 (62.4%)</td><td>0.695</td></tr><tr><td>NYHA IV</td><td>61 (23.7%)</td><td>31 (20.9%)</td><td>30 (27.5%)</td><td>0.238</td></tr></table>
1ad3e88572c8f30f819fa70542481641db8757b9fbee1a6ec345b56a2b06e9ec.png
complex
<table><tr><td>Strain</td><td>Gene name</td><td>Protein name</td><td>Metabolic function</td><td>Fold change</td></tr><tr><td rowspan="7">P5</td><td><i>TPI1</i></td><td>Triosephosphateisomerase</td><td>Glycolisis</td><td>27.28</td></tr><tr><td><i>AHP1</i></td><td>Peroxiredoxin type-2</td><td>Oxidative stress</td><td>20.07</td></tr><tr><td><i>PDC1</i></td><td>Pyruvate DeCarboxylase</td><td>Glycolisis, Glucose fermentation</td><td>13.95</td></tr><tr><td><i>TSA1</i></td><td>Thioredoxin peroxidase</td><td>Oxidative stress</td><td>5.28</td></tr><tr><td><i>CDC19</i></td><td>Pyruvatekinase</td><td>Glycolisis, Glucose fermentation</td><td>5.16</td></tr><tr><td><i>ENO2</i></td><td>Enolase II, phosphopyruvatehydratase</td><td>Glycolisis</td><td>3.28</td></tr><tr><td><i>FBA1</i></td><td>Fructose 1,6-bisphosphate aldolase</td><td>Glycolisis</td><td>2.15</td></tr><tr><td rowspan="6">P24</td><td><i>RPL31A</i></td><td>Ribosomal Protein of the Large subunit</td><td>Structural constituent of ribosome</td><td>17.65</td></tr><tr><td><i>TDH1</i></td><td>Glyceraldehyde-3-phosphate dehydrogenase</td><td>Glycolisis</td><td>7.11</td></tr><tr><td><i>TEF1</i></td><td>Translational elongation factor EF-1 alpha</td><td>Translation</td><td>5.12</td></tr><tr><td><i>TDH3</i></td><td>Glyceraldehyde-3-phosphate dehydrogenase</td><td>Glycolisis</td><td>4.76</td></tr><tr><td><i>GPM1</i></td><td>Glycerate phosphomutase</td><td>Glycolisis</td><td>3.53</td></tr><tr><td><i>ENO2</i></td><td>Enolase II, phosphopyruvatehydratase</td><td>Glycolisis</td><td>-4.09</td></tr></table>
6be35e39e6dcda57a19fd2145e4771f0a846e29466641c62541ab2a4d38452a8.png
simple
<table><tr><td>Protein</td><td>Species</td><td>Mitochondrial function</td><td>Stimulus driving mitochondrial localization</td><td>Reference</td></tr><tr><td>NF-&#954;B</td><td>Rat, mouse</td><td>Suppression of mitochondrial genes</td><td>Steady-state conditions</td><td>Johnson et al., 2011; Johnson and Perkins, 2012</td></tr><tr><td>CREB</td><td>Rat, mouse</td><td>Activation of mitochondrial genes</td><td>Steady-state conditions</td><td>Lee et al., 2005; Ryu et al., 2005</td></tr><tr><td>MEF-2D</td><td>Mouse</td><td>Transcriptional Activation of ND6</td><td>Steady-state conditions</td><td>She et al., 2011</td></tr><tr><td>TERT</td><td>Human, mouse, Rat</td><td>Reverse Transcription of mitochondrial tRNAs,Protection from mtDNA damage</td><td>Oxidative stress, steady state conditions</td><td>Haendeler et al., 2009; Sharma et al., 2012; Saretzki, 2014</td></tr><tr><td>RECQL4</td><td>Human, mouse</td><td>Restores mtDNA replication, Ensures mtDNA integrity</td><td>Steady-state conditions</td><td>De et al., 2012; Gupta et al., 2014; Wang et al., 2014; Lu et al., 2016</td></tr><tr><td>STAT3</td><td>Mouse, human</td><td>Modulation ETC through direct binding to respiratory complexes</td><td>Steady-state conditionsActivated Ras</td><td>Gough et al., 2009; Wegrzyn et al., 2009</td></tr><tr><td>P53</td><td>Rat, mouse, human</td><td>Modulation of mitochondrial permeability, apoptosis and necrosis,Promotion of mtDNA accuracy and stability.</td><td>Pro-apoptotic signals, oxidative stress, hypoxia, ultraviolet irradiation</td><td>Jiang et al., 2006; Marchenko et al., 2007; Bakhanashvili et al., 2008; Vaseva et al., 2012</td></tr><tr><td>IRF3</td><td>Human</td><td>Apoptosis induction by mitochondrial recruitment of BAX</td><td>RNA virus infection</td><td>Chattopadhyay et al., 2010</td></tr><tr><td>STAT1</td><td>Mouse, Rat</td><td>ND</td><td>Steady-state conditions</td><td>Boengler et al., 2010</td></tr><tr><td>HIF-1&#945;</td><td>Human</td><td>ND</td><td>Hypoxia</td><td>Briston et al., 2011</td></tr></table>
ab5e3cf3a029309cd31d53e8c09cdce0eef849fefbf797033d5e7a96f256eb91.png
complex
<table><tr><td></td><td></td><td colspan="3">30&#8211;59 yrs. old</td><td colspan="3">&#8805;60 yrs. old</td></tr><tr><td></td><td>Causes</td><td>2010&#8211;2012n (%)</td><td>2013&#8211;2015n (%)</td><td>Totaln (%)</td><td>2010&#8211;2012n(%)</td><td>2013&#8211;2015n (%)</td><td>Totaln (%)</td></tr><tr><td rowspan="8">Blindness</td><td>MMD</td><td>9(34.6)</td><td>7(25.9)</td><td>16(30.2)</td><td>14(19.2)</td><td>18(22.8)</td><td>32(21.1)</td></tr><tr><td>Glaucoma</td><td>5(19.2)</td><td>5(18.5)</td><td>10(18.9)</td><td>15(20.5)</td><td>17(21.5)</td><td>32(21.1)</td></tr><tr><td>AMD</td><td>0(0)</td><td>0(0)</td><td>0(0)</td><td>20(27.4)</td><td>17(21.5)</td><td>37(24.3)</td></tr><tr><td>DR</td><td>3(11.5)</td><td>7(25.9)</td><td>10(18.9)</td><td>3(4.1)</td><td>5(6.3)</td><td>8(5.3)</td></tr><tr><td>ONA</td><td>3(11.5)</td><td>1(3.7)</td><td>4(7.5)</td><td>4(5.5)</td><td>5(6.3)</td><td>9(5.9)</td></tr><tr><td>RP</td><td>5(19.5)</td><td>6(22.2)</td><td>11(20.8)</td><td>4(5.5)</td><td>4(5.1)</td><td>8(5.3)</td></tr><tr><td>Others</td><td>1(3.7)</td><td>1(3.7)</td><td>2(3.8)</td><td>13(17.8)</td><td>13(16.5)</td><td>26(17.1)</td></tr><tr><td>Total</td><td>26</td><td>27</td><td>53</td><td>73</td><td>79</td><td>152</td></tr><tr><td rowspan="6">Low Vision</td><td>MMD</td><td>55(78.6)</td><td>57(70.4)</td><td>112(74.2)</td><td>53(42.7)</td><td>95(57.9)</td><td>148(51.4)</td></tr><tr><td>Glaucoma</td><td>1(1.4)</td><td>3(3.7)</td><td>4(2.6)</td><td>10(8.1)</td><td>10(6.1)</td><td>20(6.9)</td></tr><tr><td>AMD</td><td>3(4.3)</td><td>3(3.7)</td><td>6(3.9)</td><td>35(28.2)</td><td>31(18.9)</td><td>66(22.9)</td></tr><tr><td>DR</td><td>1(1.4)</td><td>13(16.0)</td><td>14(9.3)</td><td>8(6.5)</td><td>10(6.1)</td><td>18(6.3)</td></tr><tr><td>Others</td><td>10(14.2)</td><td>5(6.2)</td><td>15(9.9)</td><td>18(14.5)</td><td>18(11.0)</td><td>36(12.5)</td></tr><tr><td>Total</td><td>70</td><td>81</td><td>151</td><td>124</td><td>164</td><td>288</td></tr></table>
b61b96bb11bd63adc7319e927351bc97bcff1ace3589b127c264a612cf0ee469.png
complex
<table><tr><td colspan="6">Growth and nutritional status of rats</td></tr><tr><td></td><td>Body weight gain (g)</td><td>Liver weight (g)</td><td>Food intake (g/day)</td><td>Water intake (ml/day)</td><td>Feed efficiency (B.W gain/food intake)</td></tr><tr><td><i>C</i></td><td>16.4 &#177; 6.67<sup>a</sup></td><td>6.92 &#177; 1.42 <sup>a</sup></td><td>16.03 &#177; 2.47<sup>a</sup></td><td>9.33 &#177; 1.91 <sup>ab</sup></td><td>1.02</td></tr><tr><td><i>FSO</i></td><td>24.55 &#177; 9.7 <sup>a</sup></td><td>8.15 &#177; 0.83 <sup>b</sup></td><td>14.94 &#177; 1.82 <sup>ab</sup></td><td>10.04 &#177; 1.53 <sup>a</sup></td><td>1.64</td></tr><tr><td><i>OSO</i></td><td>20.33 &#177; 7.81 <sup>a</sup></td><td>7.54 &#177; 0.64 <sup>ab</sup></td><td>13.74 &#177; 2.41<sup>c</sup></td><td>9.82 &#177; 1.5 <sup>ab</sup></td><td>1.47</td></tr><tr><td><i>MG</i></td><td>25.83 &#177; 6.64 <sup>a</sup></td><td>7.27 &#177; 0.7 <sup>a</sup></td><td>14.24 &#177; 2.17 <sup>bc</sup></td><td>9.07 &#177; 1.22 <sup>b</sup></td><td>1.81</td></tr></table>
b65969446b6b3ad94c1d4ebfe7a17ad058dbd45bdaad0f33c91bb51586d4e1e6.png
simple
<table><tr><td>Variable</td><td>StapleMean (SD)</td><td>SutureMean (SD)</td><td><i>t</i> value</td><td><i>P</i> value</td></tr><tr><td>Nurse VAS score on day 5</td><td>7.57 (1.30)</td><td>7.00 (1.10)</td><td>2.31</td><td>0.023</td></tr><tr><td>Nurse VAS score at 6 weeks</td><td>8.71 (1.45) </td><td>8.55 (1.23) </td><td>0.58</td><td>0.566</td></tr><tr><td>Nurse observer scar width (OSAS) score</td><td>1.94 (0.67)</td><td>2.26 (1.01)</td><td>&#8722;1.80</td><td>0.075</td></tr><tr><td>Nurse observer scar height (OSAS) score</td><td>1.74 (0.74)</td><td>2.09 (0.86)</td><td>&#8722;2.07</td><td>0.041</td></tr><tr><td>Nurse observer scar pliability (OSAS) score</td><td>2.06 (1.13) </td><td>2.36 (1.11)</td><td>&#8722;1.288</td><td>0.201</td></tr><tr><td>Total nurse OSAS score+</td><td>5.74 (1.87)</td><td>6.70 (2.62)</td><td>&#8722;2.039</td><td>0.044</td></tr><tr><td>Observer 1 VAS score at 6 weeks</td><td>8.00 (0.91)</td><td>8.32 (1.00)</td><td>&#8722;1.62</td><td>0.109</td></tr><tr><td>Observer 2 VAS score at 6 weeks</td><td>5.34 (1.81)</td><td>5.91 (1.90)</td><td>&#8722;1.50</td><td>0.136</td></tr><tr><td>Average VAS score</td><td>6.67 (1.19)</td><td>7.11 (1.33)</td><td>&#8722;1.71</td><td>0.091</td></tr><tr><td>Observer 1 OSAS width</td><td>2.49 (0.72)</td><td>2.32 (0.78)</td><td>1.10</td><td>0.275</td></tr><tr><td>Observer 2 OSAS width</td><td>4.55 (1.73)</td><td>4.26 (1.71)</td><td>0.84</td><td>0.404</td></tr><tr><td>Observer 1 OSAS height</td><td>2.26 (0.94)</td><td>2.19 (1.10)</td><td>0.30</td><td>0.763</td></tr><tr><td>Observer 1 OSAS height</td><td>3.51 (1.49)</td><td>3.51 (1.53)</td><td>&#8722;0.14</td><td>0.892</td></tr><tr><td>Average OSAS score</td><td>6.40 (1.78)</td><td>6.15 (1.92)</td><td>0.64</td><td>0.524</td></tr></table>
e2334bd2a3e77efbdb10a03cf959238f489865ff29791b055ee2b25dd6a45860.png
simple
<table><tr><td>Size</td><td>5 &#956;m</td><td>10 &#956;m</td><td>15 &#956;m</td><td>20 &#956;m</td></tr><tr><td>Breakdown voltage</td><td>21.25 V</td><td>12 V</td><td>11.8 V</td><td>11.7 V</td></tr><tr><td>Dark current</td><td>200 pA</td><td>60 pA</td><td>85 pA</td><td>106 pA</td></tr></table>
19b75438886168da154736b7e91b65fc194261074ddf3169b9834ba531316216.png
complex
<table><tr><td>Sample (&#956;g/100 &#956;L)</td><td colspan="4">% Inhibition of DPPH</td></tr><tr><td></td><td>Crude extract <sup>a</sup></td><td>Acidic fraction <sup>b</sup></td><td>Neutral fraction <sup>c</sup></td><td>Oil fraction <sup>d</sup></td></tr><tr><td>Ajwain</td><td></td><td></td><td></td><td></td></tr><tr><td>50</td><td>66.3 &#177; 1.5</td><td>60.4 &#177; 2.6</td><td>51.3 &#177; 2.4</td><td>60.3 &#177; 1.4</td></tr><tr><td>100</td><td>74.5 &#177; 1.0</td><td>69.5 &#177; 2.9</td><td>61.6 &#177; 3.0</td><td>67.6 &#177; 2.0</td></tr><tr><td>150</td><td>83.6 &#177; 2.3</td><td>76.5 &#177; 1.6</td><td>68.6 &#177; 2.1</td><td>77.5 &#177; 2.3</td></tr><tr><td>200</td><td>90.6 &#177; 2.8</td><td>85.4 &#177; 1.9</td><td>77.5 &#177; 2.4</td><td>83.0 &#177; 1.8</td></tr><tr><td>250</td><td>95.7 &#177; 3.0</td><td>91.6 &#177; 2.9</td><td>83.4 &#177; 1.8</td><td>88.0 &#177; 2.1</td></tr><tr><td>Mustard seeds</td><td></td><td></td><td></td><td></td></tr><tr><td>50</td><td>57.0 &#177; 1.5</td><td>45.2 &#177; 1.2</td><td>37.1 &#177; 0.6</td><td>51.0 &#177; 1.5</td></tr><tr><td>100</td><td>59.2 &#177; 0.8</td><td>52.6 &#177; 1.7</td><td>44.2<i> &#177;</i> 1.5</td><td>56.2 &#177; 0.9</td></tr><tr><td>150</td><td>66.5 &#177; 2.5</td><td>61.8 &#177; 2.1</td><td>54.4<i> &#177;</i> 2.1</td><td>60.5 &#177; 2.6</td></tr><tr><td>200</td><td>73.5 &#177; 2.1</td><td>68.7 &#177; 1.5</td><td>59.6<i> &#177;</i> 3.0</td><td>67.5 &#177; 2.1</td></tr><tr><td>250</td><td>79.4 &#177; 1.5</td><td>74.5 &#177; 0.9</td><td>65.8 &#177; 2.9</td><td>73.4 &#177; 1.6</td></tr><tr><td>Fenugreek</td><td></td><td></td><td></td><td></td></tr><tr><td>50</td><td>50.4 &#177; 0.5</td><td>43.2 &#177; 2.3</td><td>35.1 &#177; 2.3</td><td>43.6 &#177; 1.5</td></tr><tr><td>100</td><td>55.3 &#177; 1.6</td><td>49.5 &#177; 2.5</td><td>40.6 &#177; 2.2</td><td>49.7 &#177; 2.6</td></tr><tr><td>150</td><td>62.0 &#177; 2.1</td><td>56.5 &#177; 1.8</td><td>47.7 &#177; 2.1</td><td>54.2 &#177; 1.1</td></tr><tr><td>200</td><td>67.0 &#177; 1.9</td><td>61.4 &#177; 1.9</td><td>55.8 &#177; 1.9</td><td>59.5 &#177; 1.8</td></tr><tr><td>250</td><td>73.0 &#177; 1.8</td><td>67.2 &#177; 2.1</td><td>60.7 &#177; 1.1</td><td>65.5 &#177; 2.8</td></tr><tr><td>Poppy seeds</td><td></td><td></td><td></td><td></td></tr><tr><td>50</td><td>44.0 &#177; 1.0</td><td>38.5 &#177; 0.9</td><td>29.0 &#177; 1.5</td><td>37.2 &#177; 1.0</td></tr><tr><td>100</td><td>53.0 &#177; 1.5</td><td>43.5 &#177; 1.3</td><td>35.0 &#177; 3.0</td><td>44.7 &#177; 1.5</td></tr><tr><td>150</td><td>59.0 &#177; 2.3</td><td>49.5 &#177; 1.5</td><td>40.0 &#177; 2.8</td><td>49.5 &#177; 2.3</td></tr><tr><td>200</td><td>63.0 &#177; 1.8</td><td>55.0 &#177; 1.9</td><td>46.0 &#177; 2.7</td><td>54.0 &#177; 1.8</td></tr><tr><td>250</td><td>66.5 &#177; 0.6</td><td>62.0 &#177; 3.0</td><td>55.5 &#177; 1.6</td><td>60.5 &#177; 0.6</td></tr></table>
dc1422e5416358850016ac930e68752775b6f23106995f7c37b87289a607e2e3.png
complex
<table><tr><td rowspan="2">Clinical parameters</td><td colspan="4"><i>KAP1</i></td><td colspan="4"><i>TIMP1</i></td><td colspan="4"><i>STC2</i></td></tr><tr><td>Low</td><td>High</td><td>&#967;<sup>2</sup></td><td><i>P</i></td><td>Low</td><td>High</td><td>&#967;<sup>2</sup></td><td>P</td><td>Low</td><td>High</td><td>&#967;<sup>2</sup></td><td><i>P</i></td></tr><tr><td>N</td><td>13</td><td>99</td><td> </td><td> </td><td>12</td><td>100</td><td> </td><td> </td><td>11</td><td>101</td><td> </td><td> </td></tr><tr><td>Gender</td><td> </td><td> </td><td>1.52</td><td>0.22</td><td> </td><td> </td><td>0.68</td><td>0.41</td><td> </td><td> </td><td>3.08</td><td>0.079</td></tr><tr><td>Male</td><td>7</td><td>70</td><td> </td><td> </td><td>7</td><td>70</td><td> </td><td> </td><td>5</td><td>72</td><td> </td><td> </td></tr><tr><td>Female</td><td>6</td><td>29</td><td> </td><td> </td><td>5</td><td>30</td><td> </td><td> </td><td>6</td><td>29</td><td> </td><td> </td></tr><tr><td>Location</td><td> </td><td> </td><td>0.184</td><td>0.91</td><td> </td><td> </td><td>1.82</td><td>0.40</td><td> </td><td> </td><td>1.99</td><td>0.369</td></tr><tr><td>Proximal</td><td>1</td><td>11</td><td> </td><td> </td><td>0</td><td>12</td><td> </td><td> </td><td>0</td><td>12</td><td> </td><td> </td></tr><tr><td>Middle</td><td>4</td><td>32</td><td> </td><td> </td><td>5</td><td>31</td><td> </td><td> </td><td>5</td><td>31</td><td> </td><td> </td></tr><tr><td>Distal</td><td>8</td><td>56</td><td> </td><td> </td><td>7</td><td>57</td><td> </td><td> </td><td>6</td><td>58</td><td> </td><td> </td></tr><tr><td>Size</td><td> </td><td> </td><td>0.227</td><td>0.633</td><td> </td><td> </td><td>0.156</td><td>0.693</td><td> </td><td> </td><td>0.484</td><td>0.487</td></tr><tr><td>&lt;5 cm</td><td>5</td><td>45</td><td> </td><td> </td><td>6</td><td>44</td><td> </td><td> </td><td>6</td><td>44</td><td> </td><td> </td></tr><tr><td>&#8805;5 cm</td><td>8</td><td>54</td><td> </td><td> </td><td>6</td><td>56</td><td> </td><td> </td><td>5</td><td>57</td><td> </td><td> </td></tr><tr><td>Lauren classification</td><td> </td><td> </td><td>0.56</td><td>0.45</td><td> </td><td> </td><td>0.55</td><td>0.46</td><td> </td><td> </td><td>0.037</td><td>0.85</td></tr><tr><td>Intestinal</td><td>8</td><td>50</td><td> </td><td> </td><td>5</td><td>53</td><td> </td><td> </td><td>6</td><td>52</td><td> </td><td> </td></tr><tr><td>Diffuse</td><td>5</td><td>49</td><td> </td><td> </td><td>7</td><td>47</td><td> </td><td> </td><td>5</td><td>49</td><td> </td><td> </td></tr><tr><td>Histology</td><td> </td><td> </td><td>1.53</td><td>0.675</td><td> </td><td> </td><td>5.376</td><td>0.146</td><td> </td><td> </td><td>2.62</td><td>0.454</td></tr><tr><td>Papillary adenocarcinoma</td><td>0</td><td>5</td><td> </td><td> </td><td>0</td><td>5</td><td> </td><td> </td><td>0</td><td>5</td><td> </td><td> </td></tr><tr><td>Tubular adenocarcinoma</td><td>11</td><td>69</td><td> </td><td> </td><td>12</td><td>68</td><td> </td><td> </td><td>10</td><td>70</td><td> </td><td> </td></tr><tr><td>Mucinous adenocarcinoma</td><td>1</td><td>15</td><td> </td><td> </td><td>0</td><td>16</td><td> </td><td> </td><td>1</td><td>15</td><td> </td><td> </td></tr><tr><td>Signet-ring cell carcinoma</td><td>1</td><td>10</td><td> </td><td> </td><td>0</td><td>11</td><td> </td><td> </td><td>0</td><td>11</td><td> </td><td> </td></tr><tr><td>Histologic differentiation</td><td> </td><td> </td><td>0.013</td><td>0.91</td><td> </td><td> </td><td>1.97</td><td>0.16</td><td> </td><td> </td><td>0.10</td><td>0.75</td></tr><tr><td>Well-moderately</td><td>4</td><td>32</td><td> </td><td> </td><td>6</td><td>30</td><td> </td><td> </td><td>4</td><td>32</td><td> </td><td> </td></tr><tr><td>Poorly-undifferentiated</td><td>9</td><td>67</td><td> </td><td> </td><td>6</td><td>70</td><td> </td><td> </td><td>7</td><td>69</td><td> </td><td> </td></tr><tr><td>TNM Stages</td><td> </td><td> </td><td>24.31</td><td>0.001</td><td> </td><td> </td><td>36.46</td><td>0.001</td><td> </td><td> </td><td>20.26</td><td>0.001</td></tr><tr><td>I</td><td>7</td><td>7</td><td> </td><td> </td><td>8</td><td>6</td><td> </td><td> </td><td>6</td><td>8</td><td> </td><td> </td></tr><tr><td>II</td><td>4</td><td>36</td><td> </td><td> </td><td>2</td><td>38</td><td> </td><td> </td><td>3</td><td>37</td><td> </td><td> </td></tr><tr><td>III</td><td>2</td><td>37</td><td> </td><td> </td><td>2</td><td>37</td><td> </td><td> </td><td>1</td><td>38</td><td> </td><td> </td></tr><tr><td>IV</td><td>0</td><td>19</td><td> </td><td> </td><td>0</td><td>19</td><td> </td><td> </td><td>1</td><td>18</td><td> </td><td> </td></tr><tr><td>Lymph node metastasis</td><td> </td><td> </td><td>48.37</td><td>0.001</td><td> </td><td> </td><td>24.15</td><td>0.001</td><td> </td><td> </td><td>41.32</td><td>0.001</td></tr><tr><td>No</td><td>7</td><td>1</td><td> </td><td> </td><td>5</td><td>3</td><td> </td><td> </td><td>6</td><td>2</td><td> </td><td> </td></tr><tr><td>Yes</td><td>6</td><td>98</td><td> </td><td> </td><td>7</td><td>97</td><td> </td><td> </td><td>5</td><td>99</td><td> </td><td> </td></tr><tr><td>Distant metastasis</td><td> </td><td> </td><td>0.898</td><td>0.343</td><td> </td><td> </td><td>2.746</td><td>0.098</td><td> </td><td> </td><td>0.537</td><td>0.464</td></tr><tr><td>No</td><td>12</td><td>81</td><td> </td><td> </td><td>12</td><td>81</td><td> </td><td> </td><td>10</td><td>83</td><td> </td><td> </td></tr><tr><td>Yes</td><td>1</td><td>18</td><td> </td><td> </td><td>0</td><td>19</td><td> </td><td> </td><td>1</td><td>18</td><td> </td><td> </td></tr></table>
513c7c43e233405b55a4272b1db697356de8cbc442f5331f82d60d366eb7f0e6.png
complex
<table><tr><td colspan="4">Retention indices</td><td rowspan="3" colspan="2">Identification %</td></tr><tr><td colspan="2">van den Dool and Kratz</td><td colspan="2">Kovats</td></tr><tr><td>Calculated</td><td>Adams 2009</td><td>Calculated</td><td>Adams 2009</td></tr><tr><td>1010</td><td>1008</td><td>1011</td><td>1011</td><td>&#948;-3-carene</td><td>55.36</td></tr><tr><td>933</td><td>932</td><td>938</td><td>939</td><td>&#945;-pinene</td><td>15.62</td></tr><tr><td>1027</td><td>1025</td><td>1031</td><td>1030</td><td>sylvestrene</td><td>10.69</td></tr><tr><td>1479</td><td>1480</td><td>1481</td><td>1481</td><td>germacrene D</td><td>2.48</td></tr><tr><td>1377</td><td>1379</td><td>1379</td><td>1381</td><td>&#946;-patchoulene</td><td>1.99</td></tr><tr><td>988</td><td>988</td><td>990</td><td>990</td><td>mircene</td><td>1.89</td></tr><tr><td>1355</td><td>1356</td><td>1357</td><td>1359</td><td>eugenol</td><td>1.71</td></tr><tr><td>1087</td><td>1086</td><td>1089</td><td>1088</td><td>terpinolene</td><td>1.52</td></tr><tr><td>1392</td><td>1390</td><td>1393</td><td>1391</td><td>sativene</td><td>0.93</td></tr><tr><td>1418</td><td>1419</td><td>1419</td><td>1420</td><td>&#946;-cedrene</td><td>0.89</td></tr><tr><td>1675</td><td>1674</td><td>1676</td><td>1675</td><td>cis-&#945;-santalol</td><td>0.77</td></tr><tr><td>1447</td><td>1448</td><td>1449</td><td>1450</td><td>cis-muurola-3,5-diene</td><td>0.76</td></tr><tr><td>1546</td><td>1546</td><td>1548</td><td>1548</td><td>hedycaryol</td><td>0.66</td></tr><tr><td>1336</td><td>1335</td><td>1339</td><td>1338</td><td>&#948;-elemene</td><td>0.44</td></tr><tr><td>1434</td><td>1434</td><td>1436</td><td>1436</td><td>&#947;-elemene</td><td>0.41</td></tr><tr><td></td><td></td><td></td><td>Total</td><td></td><td>96.11</td></tr></table>
47f52de89c868a3faee42d2b4053a8f36cba18430d6b01d07bb157fec5b4dfc1.png
complex
<table><tr><td rowspan="2"><i>A</i></td><td colspan="3"><i>L</i><sub>Aeq</sub></td><td colspan="3"><i>L</i><sub>HC</sub></td></tr><tr><td>HR</td><td>CR</td><td>CR-HR</td><td>HR</td><td>CR</td><td>CR-HR</td></tr><tr><td>25</td><td>47.8</td><td>54.2</td><td>6.4</td><td>115.9</td><td>115.7</td><td>-0.2</td></tr><tr><td>28</td><td>49.2</td><td>55.6</td><td>6.4</td><td>118.4</td><td>118.3</td><td>-0.1</td></tr><tr><td>31</td><td>50.7</td><td>57.1</td><td>6.4</td><td>121.0</td><td>121.0</td><td>0.0</td></tr><tr><td>34</td><td>52.1</td><td>58.5</td><td>6.4</td><td>123.6</td><td>123.7</td><td>0.1</td></tr><tr><td>37</td><td>53.6</td><td>60.0</td><td>6.4</td><td>126.2</td><td>126.3</td><td>0.1</td></tr><tr><td>40</td><td>55.1</td><td>61.5</td><td>6.4</td><td>128.8</td><td>128.9</td><td>0.1</td></tr><tr><td>43</td><td>56.5</td><td>62.9</td><td>6.4</td><td>131.5</td><td>131.6</td><td>0.1</td></tr><tr><td>46</td><td>58.0</td><td>64.4</td><td>6.4</td><td>134.2</td><td>134.2</td><td>0.0</td></tr><tr><td>49</td><td>59.5</td><td>65.8</td><td>6.3</td><td>137.0</td><td>136.8</td><td>-0.2</td></tr><tr><td>52</td><td>60.9</td><td>67.3</td><td>6.4</td><td>139.8</td><td>139.5</td><td>-0.3</td></tr><tr><td>55</td><td>62.4</td><td>68.7</td><td>6.3</td><td>142.6</td><td>142.1</td><td>-0.5</td></tr><tr><td>58</td><td>63.9</td><td>70.2</td><td>6.3</td><td>145.5</td><td>144.7</td><td>-0.8</td></tr></table>
e2517762215fb32d4ebfacb067f15ac2d9e8c971b818da314f6b3398ee35faaa.png
simple
<table><tr><td>Point</td><td>Details</td></tr><tr><td>1</td><td>Five sites per organ</td></tr><tr><td>2</td><td>Avoidance of pressure artefacts</td></tr><tr><td>3</td><td>Elimination of secretions</td></tr><tr><td>4</td><td>Adequate focus and contrast adjustment</td></tr><tr><td>5</td><td>High quality recording</td></tr></table>
a1bdb81cec711c4b4649ed9d0c1a78948b7f1eba574f163d4ce953aea72cdf1e.png
simple
<table><tr><td></td><td>LM35</td><td>CHTM-02</td><td>MC112</td><td>MC115</td><td>MQ2</td><td>MQ8</td></tr><tr><td><i>&#956;<sub>HS</sub></i> (V)</td><td>0.2370</td><td>1.6930</td><td>0.3750</td><td>0.4620</td><td>2.8099</td><td>3.6299</td></tr><tr><td>&#916;</td><td>0.01 &#176;C</td><td>0.01%RH</td><td>1 ppm</td><td>1 ppm</td><td>1 ppm</td><td>1 ppm</td></tr></table>
7e006f391058bc55c32552016010507e1b2c50352c170cd9f8498f6ae7db9fc5.png
complex
<table><tr><td rowspan="2"></td><td>Normal</td><td>PanIN</td><td>PDAC</td><td rowspan="2"><i>P</i>-value*</td></tr><tr><td>Average No.</td><td>Average No.</td><td>Average No.</td></tr><tr><td>CD8p</td><td>107.6</td><td>90.3</td><td>58.1</td><td>0.0114</td></tr><tr><td>CD8i</td><td>13</td><td>4.2</td><td>0.6</td><td>&lt;0.0001</td></tr><tr><td>CD4p</td><td>14.2</td><td>57.8</td><td>22.5</td><td>&lt;0.0001</td></tr><tr><td>CD4i</td><td>0.09</td><td>2.03</td><td>0.3</td><td>&lt;0.0001</td></tr><tr><td>FOXP3p</td><td>3.6</td><td>7.1</td><td>10.9</td><td>&lt;0.0001</td></tr><tr><td>FOXP3i</td><td>0</td><td>0.12</td><td>0.5</td><td>&lt;0.0001</td></tr><tr><td>CD163 (M2)p</td><td>115.1</td><td>140</td><td>153.4</td><td>0.0016</td></tr><tr><td>CD163 (M2)i</td><td>1.1</td><td>3.16</td><td>3.6</td><td>&lt;0.0001</td></tr><tr><td>iNOS (M1)p</td><td>4.32</td><td>1</td><td>0.38</td><td>&lt;0.0001</td></tr><tr><td>iNOS (M1)i</td><td>0.17</td><td>0</td><td>0</td><td>0.006</td></tr></table>
36779ffe8a153edcde35882e14162745d7b91e9a876eabcc106d3e2b354af76b.png
complex
<table><tr><td></td><td colspan="3">Parent Rating Score</td></tr><tr><td>Variable</td><td><i>&#946;</i><sup>1</sup> (95% CI)</td><td><i>&#946;</i><sup>2</sup></td><td><i>p</i></td></tr><tr><td>Length-for age <i>z</i>-score</td><td>&#8722;0.416 (&#8722;0.928, 0.096)</td><td>&#8722;0.060</td><td>0.111</td></tr><tr><td>Weight-for-length <i>z</i>-score</td><td>&#8722;0.747 (&#8722;1.483, &#8722;0.010)</td><td>&#8722;0.072</td><td>0.047</td></tr><tr><td>Birth weight (kg)</td><td>&#8722;0.843 (&#8722;1.507, &#8722;0.180)</td><td>&#8722;0.094</td><td>0.013</td></tr><tr><td>Not breastfeeding <sup>3</sup></td><td>&#8722;0.284 (&#8722;0.785, 0.217)</td><td>&#8722;0.041</td><td>0.266</td></tr><tr><td><i>Duration of exclusive breastfeeding (age)</i></td><td></td><td></td><td></td></tr><tr><td>3&#8211;4 months <sup>4</sup></td><td>&#8722;0.715 (&#8722;1.209, &#8722;0.221)</td><td>&#8722;0.110</td><td>0.005</td></tr><tr><td>5&#8211;6 months <sup>4</sup></td><td>&#8722;0.975 (&#8722;1.637, &#8722;0.314)</td><td>&#8722;0.112</td><td>0.004</td></tr><tr><td>Frequent intake of jarred infant food <sup>5</sup></td><td>0.419 (&#8722;0.122, 0.961)</td><td>0.056</td><td>0.129</td></tr><tr><td>Frequent intake of commercial infant cereal <sup>5</sup></td><td>1.376 (0.892, 1.860)</td><td>0.206</td><td>&lt;0.001</td></tr><tr><td>Caregiver passed at least grade 10 <sup>6</sup></td><td>0.344 (&#8722;0.225, 0.913)</td><td>0.043</td><td>0.236</td></tr><tr><td>Male infant <sup>7</sup></td><td>0.683 (0.238, 1.127)</td><td>0.109</td><td>0.003</td></tr><tr><td>Adjusted R<sup>2</sup></td><td colspan="3">0.094</td></tr></table>
e0083bb5c9a1d049e38722b06cd717f6d39b4b42d6005e6a674fd536cba59587.png
complex
<table><tr><td>Variables</td><td>Intervention Group (<i>n</i> = 22)</td><td>Comparison Group (<i>n</i> = 22)</td><td><i>p</i>-Value</td></tr><tr><td>Sex, <i>n</i> (%)</td><td>Male, 13 (59.0)</td><td>Male, 11 (50.0)</td><td>0.763</td></tr><tr><td>GA at birth, week &#177; day</td><td>29 &#177; 12 day</td><td>30 &#177; 14 day</td><td>0.501</td></tr><tr><td>Twin, <i>n</i> (%) </td><td>3 (13.6)</td><td>6 (27.3)</td><td>0.457</td></tr><tr><td colspan="4">Growth status at birth</td></tr><tr><td>Birth weight, g</td><td>1192 &#177; 202</td><td>1151 &#177; 208</td><td>0.502</td></tr><tr><td>Length, cm</td><td>39.1 &#177; 2.6</td><td>38.4 &#177; 3.7</td><td>0.525</td></tr><tr><td>Head circumference, cm</td><td>26.1 &#177; 1.8</td><td>26.4 &#177; 1.9</td><td>0.626</td></tr><tr><td colspan="4">SGA at birth</td></tr><tr><td>Body weight, <i>n</i> (%)</td><td>1 (4.5)</td><td>2 (9.1)</td><td>1.000</td></tr><tr><td>Length, <i>n</i> (%)</td><td>1 (4.5)</td><td>1 (4.5)</td><td>1.000</td></tr><tr><td>Head circumference, <i>n</i> (%)</td><td>2 (9.1)</td><td>2 (9.1)</td><td>1.000</td></tr><tr><td colspan="4">SGA at discharge</td></tr><tr><td>Body weight, <i>n</i> (%)</td><td>19 (86.4)</td><td>20 (90.9)</td><td>1.000</td></tr><tr><td>Length, <i>n</i> (%)</td><td>10 (45.5)</td><td>14 (63.6)</td><td>0.364</td></tr><tr><td>Head circumference, <i>n</i> (%)</td><td>15 (68.2)</td><td>12 (54.5)</td><td>0.453</td></tr><tr><td>PMA at discharge, week &#177; day</td><td>37 &#177; 12 day</td><td>38 &#177; 20 day</td><td>0.199</td></tr><tr><td>LOS, days</td><td>52 &#177; 12</td><td>53 &#177; 17</td><td>0.895</td></tr><tr><td colspan="4">Feeding type at discharge, <i>n</i> (%)</td></tr><tr><td>Breast milk feeding</td><td>18 (81.8)</td><td>17 (77.3)</td><td>1.000 </td></tr><tr><td>Mixed feeding</td><td>3 (13.6)</td><td>4 (18.2)</td><td>1.000</td></tr><tr><td>Standard formula</td><td>1 (4.5)</td><td>2 (9.1)</td><td>1.000</td></tr><tr><td colspan="4">Growth status at term (40 weeks)</td></tr><tr><td>Body weight, g</td><td>2631 &#177; 538</td><td>2426 &#177; 531</td><td>0.145</td></tr><tr><td>Length, cm</td><td>47.7 &#177; 2.7</td><td>46.9 &#177; 2.9</td><td>0.318</td></tr><tr><td>Head circumference, cm</td><td>33.1 &#177; 1.6</td><td>32.2 &#177; 2.3</td><td>0.470</td></tr><tr><td>Maternal age (years)</td><td>22.5 &#177; 4.8</td><td>25.3 &#177; 5.5</td><td>0.087</td></tr></table>
150f1638e9040458c5d92e0994a4790a4b4b183ae2a36a98d93275eafb1a369e.png
simple
<table><tr><td>Patient</td><td>Sex</td><td>Age (years)</td><td>Diagnosis</td><td>SAPS II score</td><td>Pao<sub>2</sub>/Fio<sub>2 </sub>ratio (mmHg)</td><td>Crs (ml/cmH<sub>2</sub>O)</td><td>LIP (cmH<sub>2</sub>O)</td><td>Pplat (cmH<sub>2</sub>O)</td><td>UIP (cmH<sub>2</sub>O)</td></tr><tr><td>1</td><td>F</td><td>56</td><td>Aspiration</td><td>42</td><td>121</td><td>58</td><td>15</td><td>22</td><td>-</td></tr><tr><td>2</td><td>M</td><td>68</td><td>CAP</td><td>45</td><td>95</td><td>25</td><td>15</td><td>40</td><td>-</td></tr><tr><td>3</td><td>M</td><td>40</td><td>Aspiration</td><td>36</td><td>89</td><td>122</td><td>10</td><td>19</td><td>-</td></tr><tr><td>4</td><td>M</td><td>51</td><td>CAP</td><td>25</td><td>71</td><td>34</td><td>5</td><td>24</td><td>54</td></tr><tr><td>5</td><td>M</td><td>31</td><td>Aspiration</td><td>34</td><td>82</td><td>43</td><td>-</td><td>27</td><td>-</td></tr><tr><td>6</td><td>M</td><td>41</td><td><i>Pneumocystis</i></td><td>36</td><td>161</td><td>50</td><td>12</td><td>27</td><td>35</td></tr><tr><td>7</td><td>M</td><td>50</td><td>CAP</td><td>19</td><td>110</td><td>73</td><td>8</td><td>24</td><td>-</td></tr><tr><td>8</td><td>M</td><td>73</td><td><i>Legionella</i></td><td>32</td><td>72</td><td>75</td><td>13</td><td>31</td><td>-</td></tr><tr><td>9</td><td>M</td><td>31</td><td><i>Pneumocystis</i></td><td>9</td><td>112</td><td>78</td><td>-</td><td>24</td><td>-</td></tr><tr><td>10</td><td>M</td><td>31</td><td>Aspiration</td><td>74</td><td>104</td><td>55</td><td>7</td><td>26</td><td>-</td></tr><tr><td>11</td><td>M</td><td>66</td><td>Peritonitis</td><td>85</td><td>55</td><td>41</td><td>-</td><td>32</td><td>46</td></tr><tr><td>12</td><td>F</td><td>43</td><td>CAP</td><td>46</td><td>170</td><td>75</td><td>8</td><td>12</td><td>27</td></tr><tr><td>13</td><td>F</td><td>42</td><td>CAP</td><td>22</td><td>187</td><td>52</td><td>-</td><td>22</td><td>-</td></tr><tr><td>14</td><td>M</td><td>70</td><td>Aspiration</td><td>40</td><td>191</td><td>68</td><td>-</td><td>22</td><td>31</td></tr><tr><td>15</td><td>F</td><td>36</td><td>CAP</td><td>43</td><td>216</td><td>51</td><td>13</td><td>27</td><td>53</td></tr><tr><td>16</td><td>F</td><td>57</td><td>Aspiration</td><td>36</td><td>172</td><td>56</td><td>10</td><td>30</td><td>-</td></tr><tr><td>17</td><td>F</td><td>66</td><td>CAP</td><td>36</td><td>112</td><td>12</td><td>-</td><td>39</td><td>26</td></tr><tr><td></td><td></td><td>50 &#177; 15</td><td></td><td>39 &#177; 18</td><td>134 &#177; 60</td><td>56 &#177; 26</td><td></td><td>27 &#177; 7</td><td></td></tr></table>
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<table><tr><td></td><td></td><td></td><td>Unstandardized estimates</td><td>S.E.</td><td>C.R.</td><td>P</td><td>Standardized estimates</td></tr><tr><td>PRIVATE HEALTH INSURANCE COVERAGE</td><td>&lt;---</td><td>PERCEIVED HEALTH</td><td>-.038</td><td>.014</td><td>2.825</td><td>.005</td><td>-.010</td></tr><tr><td>PRIVATE HEALTH INSURANCE COVERAGE</td><td>&lt;---</td><td>PERCEIVED NEED</td><td>-.041</td><td>.029</td><td>-1.403</td><td>.161</td><td>-.08</td></tr><tr><td>PRIVATE HEALTH INSURANCE COVERAGE</td><td>&lt;---</td><td>PERCEIVED VALUE</td><td>-.041</td><td>.014</td><td>-2.875</td><td>.004</td><td>-.07</td></tr><tr><td>PRIVATE HEALTH INSURANCE COVERAGE</td><td>&lt;---</td><td>SES</td><td>.071</td><td>.014</td><td>5.230</td><td>***</td><td>.24</td></tr><tr><td>PRIVATE HEALTH INSURANCE COVERAGE</td><td>&lt;---</td><td>GENDER</td><td>.006</td><td>.027</td><td>.225</td><td>.822</td><td>-.06</td></tr><tr><td>PRIVATE HEALTH INSURANCE COVERAGE</td><td>&lt;---</td><td>AFRICAN AMERICAN</td><td>-.175</td><td>.037</td><td>-4.742</td><td>***</td><td>-.226</td></tr><tr><td>PRIVATE HEALTH INSURANCE COVERAGE</td><td>&lt;---</td><td>HISPANIC</td><td>-.252</td><td>.034</td><td>-7.332</td><td>***</td><td>-.18</td></tr></table>
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<table><tr><td>Inclusion criteria</td><td>Exclusion criteria</td></tr><tr><td>1. Study design: interventional or observational</td><td>1. Studies of exclusively pediatric population (age &lt;18 years)</td></tr><tr><td>2. Included population: hospitalized aSAH patients</td><td>2. Non-human studies</td></tr><tr><td>3. Included intervention: RBC transfusion</td><td>3. Duplicates or &#8216;sub-cohorts&#8217; of previously published cohorts</td></tr><tr><td>4. Comparator: a different transfusion threshold or no transfusion</td><td></td></tr><tr><td>5. Study outcome: any</td><td></td></tr></table>
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<table><tr><td>MIxS-BE term</td></tr><tr><td>Carbon dioxidea</td></tr><tr><td>Ventilation typea</td></tr><tr><td>Organism counta</td></tr><tr><td> </td></tr><tr><td>BE core</td></tr><tr><td> Surface material</td></tr><tr><td> Surface-air contaminant</td></tr><tr><td> Relative air humidity</td></tr><tr><td> Absolute air humidity</td></tr><tr><td> Surface humidity</td></tr><tr><td> Air temperature</td></tr><tr><td> Surface temperature</td></tr><tr><td> Surface moisture pH</td></tr><tr><td> Surface moisture</td></tr><tr><td> Dew point</td></tr><tr><td> Building occupancy type</td></tr><tr><td> </td></tr><tr><td>BE Building properties</td></tr><tr><td> Indoor space (room type)</td></tr><tr><td> Indoor surface</td></tr><tr><td> Filter type</td></tr><tr><td> Heating and cooling system type</td></tr><tr><td> Substructure type</td></tr><tr><td> Building setting</td></tr><tr><td> Light type</td></tr><tr><td> </td></tr><tr><td>BE Sample properties</td></tr><tr><td> Sample size sorting method</td></tr><tr><td> Space typical state</td></tr><tr><td> Typical occupant density</td></tr><tr><td> Occupancy at sampling</td></tr><tr><td> Occupant density at sampling</td></tr></table>
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<table><tr><td>Dose studied</td><td>100 &#956;g</td><td>200 &#956;g</td><td>400 &#956;g</td><td>600 &#956;g</td><td>800 &#956;g</td></tr><tr><td>1</td><td>&#8730;</td><td></td><td>&#8730;</td><td></td><td></td></tr><tr><td>2</td><td>&#8730;</td><td></td><td></td><td>&#8730;</td><td></td></tr><tr><td>3</td><td></td><td>&#8730;</td><td></td><td></td><td>&#8730;</td></tr><tr><td>4</td><td></td><td>&#8730;</td><td>&#8730;</td><td></td><td></td></tr></table>
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<table><tr><td rowspan="3">Locality</td><td rowspan="2" colspan="2">Sample size</td><td colspan="4">CHIKV titer Median copy number (IQR)</td></tr><tr><td colspan="2">w+</td><td colspan="2">w&#8722;</td></tr><tr><td>w+</td><td>w&#8722;</td><td>Midguts</td><td>Salivary glands</td><td>Midguts</td><td>Salivary glands</td></tr><tr><td>Besar Island, Malacca</td><td>55</td><td>59</td><td>6.07 (5.21, 6.93)<sup>a</sup>*</td><td>2.38 (1.63, 4.63)<sup>a</sup></td><td>7.02 (4.01, 7.80)<sup>a</sup></td><td>2.16 (1.22, 3.45)<sup>a</sup></td></tr><tr><td>Tenggol Island, Terengganu</td><td>58</td><td>60</td><td>7.44 (5.20, 8.09)<sup>b</sup></td><td>2.70 (1.45, 6.36)<sup>a</sup></td><td>7.83 (6.10, 8.53)<sup>b</sup></td><td>2.25 (1.44, 4.34)<sup>a</sup></td></tr><tr><td>Bandar Rinching, Selangor</td><td>60</td><td>57</td><td>7.01 (6.04, 7.69)<sup>b</sup></td><td>2.93 (1.73, 5.39)<sup>a</sup></td><td>6.98 (6.02, 7.50)<sup>a</sup></td><td>2.81 (1.28, 5.50)<sup>a</sup></td></tr></table>