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pain\tand\tneed\n\tfor\tmedication\nNone\treported\nCreatine\nIncreases\tlean\tmass\nand\tstrength,\nenhances\trecovery\nfrom\tintense\nexercise;\tenhances\nadaptive\tresponse\nto\texercise;\nincreases\nintracellular\twater;\nenhances\trecovery\nfrom\tDOMS;\ndecreased\nrisk/enhanced\nrecovery\tfrom\tTBI\nWell\tstudied,\tshows\tbenefit\tfor\thigh-\nintensity\tintermittent\tactivity,
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duration\tof\tGI\ndistress;\tdecreased\nincidence\tduration\nand\tseverity\tof\tURTI\nModest\tbenefits\tto\tathletes\tw/GI\nissues\tor\ttraveling\tto\tregions\nwhich\tGI\tissues\tmore\tlikely;\tmost\nstudies\treport\treduced\tincidence\nof\tURTI\tbut\tspecific\nrecommendations/strains\tdifficult\nto\tascertain\nDosing\tregimens\nof\t10\t(9)\tto\t4\tx\n10\t(10)\tfor\t4-\n21\tweeks\nCOQ\n10
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Dosing\tregimens\nof\t10\t(9)\tto\t4\tx\n10\t(10)\tfor\t4-\n21\tweeks\nCOQ\n10\nCofactor\tfor\tATP\nproduction;\telectron\ntransport\tin\nmitochondria;\nreduces\tfatigue\nMixed:\tdouble-blinded,\tplacebo,\ncrossover\ttrial,\t100\tmg/d\tfor\t2\nmonths,\tlift\tloads\tof\t75\tg/kg\tof\nbody\tweight\t5x/30\ts\timproved\nmean\tpower;\tmay\timprove\tin\tthose\nwith\tmitochondrial\tdisorders\tor
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mean\tpower;\tmay\timprove\tin\tthose\nwith\tmitochondrial\tdisorders\tor\nCoQ\tdeficiency\nSodium\nbicarbonate/sodium\ncitrate\nBuffers\tlactic\tacid\nproduction;\tdelays\nfatigue\nHigh\tlevel\tof\tintraindividual\nvariability\tin\tperformance;\nincreases\tbody’s\tability\tto\tbuffer\nlactic\tacid\tduring\tsub\tmax\texercise\nfor\tevents\n\tlasting\t1-7\tmin\nStomach\tdistress:\nbloating,
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0.031052805483341217, -0.015354778617620468, 0.07487549632787704, -0.008727644570171833, -0.02046262100338936, 0.01727815717458725, 0.0069249337539076805, 0.06038769707083702, -0.03563902527093887, 0.056654345244169235, 0.01376273576170206, -0.05565996095538139, -0.1296878457069397, -0.020463520660996437, 0.01909642107784748, -0.04051783308386803, 0.0611233115196228, 0.023049984127283096, 0.024254946038126945, -0.03359723091125488, 0.07605206966400146, -0.10868379473686218, 0.030041245743632317, 0.04056205973029137, 0.07573380321264267, -0.02331359125673771, 0.0009971483377739787, 0.05470559746026993, 0.05162384733557701, 0.033760689198970795, -0.026109470054507256, -0.004078546538949013, 0.08090055733919144, -0.057244110852479935, 0.020341157913208008, -0.015945715829730034, 0.017889097332954407, -0.08532331138849258, 0.002772960579022765, 0.07872506231069565, 0.01597040705382824, 0.07114386558532715, 0.0018948912620544434, 0.032885923981666565, -0.01230742409825325, -0.04269225150346756, -0.13174763321876526, -0.024732450023293495, 0.023042133077979088, 0.08865416795015335, 0.002528709126636386, -0.06874482333660126, -0.006464769132435322, 0.017668990418314934, -0.06479130685329437, -0.014943999238312244, -0.09449056535959244, -0.06628682464361191, -0.031112883239984512, 0.019496772438287735, -0.01830030418932438, 0.030984755605459213, -0.015904273837804794, 0.05284527689218521, -0.08970698714256287, -0.07147655636072159, -0.05521862581372261, -0.016626650467514992, -0.05619557574391365, 0.03889475017786026, -0.0013192570768296719, -0.03164010867476463, -0.11849295347929001, 0.0826493576169014, -0.08718595653772354, 0.053190939128398895, -0.052148181945085526, -0.05838179960846901, -0.05751018971204758, -0.02161417528986931, 0.04751864820718765, -0.006460700184106827, -0.01553401816636324, 0.00718080485239625, 0.045861124992370605, 0.020839214324951172, 0.05859209597110748, 0.05932354927062988, 0.03406013175845146, 0.032661378383636475, 0.054906245321035385, 0.001286023180000484, 0.09484627097845078, 0.021762046962976456, -4.997767177883361e-8, 0.015917647629976273, -0.02991541102528572, 0.016967985779047012, 0.020799167454242706, 0.04146873950958252, 0.014337355270981789, 0.03456968069076538, -0.01734446920454502, -0.003569475607946515, -0.06042565032839775, 0.06451664119958878, 0.07026327401399612, -0.055953916162252426, -0.025209302082657814, 0.07553674280643463, 0.041957300156354904, -0.03784659132361412, 0.13892774283885956, -0.048427507281303406, -0.0667327344417572, 0.008429017849266529, 0.0756286159157753, -0.028166642412543297, 0.04628882184624672, -0.006203850731253624, -0.007223429158329964, -0.04336840659379959, -0.03859153017401695, 0.012872064486145973, 0.014375780709087849, 0.05934247374534607, -0.010770495049655437, 0.03629413619637489, -0.05984409525990486, -0.030051905661821365, 0.06932373344898224, -0.02182181365787983, -0.027565577998757362, -0.03393641486763954, 0.10948541760444641, -0.06017705798149109, -0.049185264855623245, -0.022007258608937263, 0.07816332578659058, 0.06084747239947319, -0.06416115909814835, -0.037272077053785324, 0.08189796656370163, 0.031362082809209824, -0.05336146801710129, 0.015350709669291973, 0.04788075387477875, -0.02880098670721054, -0.049916066229343414, -0.01438127364963293, 0.06676016747951508, 0.0394936166703701, 0.02660883590579033, -0.04564657434821129, -0.0038721526507288218, 0.09242691099643707, 0.039115797728300095, 0.05909179523587227, -0.045510996133089066 ]
for\tevents\n\tlasting\t1-7\tmin\nStomach\tdistress:\nbloating,\ndiarrhea;\ndangerous\tin\nhigh\tdoses;\nalkalosis;\ndosing\twith\nsmall\ncarbohydrate\nmeal\tmay\nreduce\tGI\nupset\nSodium\tphosphate\nBuffer\nSome;\tincreases\tVO\n2\nmax\tand\nanaerobic\tthreshold\tby\t5%-10%;\nimproves\tendurance\nStomach\tdistress\nCreatine\nImproves\tstrength,\npower,\tand\nIncreases\tmuscle\tfree\tcreatine,
[ -0.026368776336312294, -0.08656346052885056, -0.008535484783351421, 0.028024518862366676, -0.06825928390026093, -0.0009745715651661158, 0.05811123177409172, 0.08244214951992035, -0.07806035131216049, 0.02888830564916134, 0.04594649001955986, -0.0322355255484581, 0.051082100719213486, 0.051333166658878326, -0.08774879574775696, -0.04313343018293381, 0.044235825538635254, 0.0037977388128638268, -0.014025331474840641, -0.02213246561586857, 0.05220867693424225, 0.05312963202595711, 0.09934926778078079, -0.010755021125078201, 0.04976017028093338, 0.03584400564432144, -0.05478903651237488, 0.024882009252905846, -0.0207485593855381, -0.04865175485610962, -0.09319855272769928, -0.015647921711206436, 0.07463590055704117, -0.07514099031686783, 0.025493092834949493, 0.02063087560236454, -0.08806673437356949, 0.024785539135336876, -0.008900221437215805, 0.08652440458536148, 0.04549676924943924, -0.05590561404824257, -0.045739252120256424, 0.0029869768768548965, 0.01206822507083416, 0.04231094568967819, -0.016202237457036972, -0.035217128694057465, 0.025953194126486778, 0.04364093393087387, -0.017508534714579582, -0.05794183909893036, -0.010866748169064522, 0.09731541574001312, 0.019488204270601273, -0.06371685117483139, -0.03212004154920578, -0.05192761868238449, -0.031476058065891266, 0.045640259981155396, 0.01891367696225643, -0.011200802400708199, -0.013490954414010048, 0.03267993777990341, 0.013023803010582924, 0.04009344428777695, -0.027745995670557022, 0.015253284014761448, 0.010068881325423717, 0.055828291922807693, -0.054665129631757736, -0.0055785165168344975, -0.002258462132886052, 0.0728217139840126, -0.06216099113225937, 0.06953804939985275, 0.09063299745321274, -0.047963324934244156, 0.021074621006846428, -0.03737955167889595, -0.04735659435391426, 0.0543433241546154, 0.04589568451046944, 0.02600674331188202, -0.01606426201760769, 0.034493058919906616, -0.01024402305483818, 0.08048088103532791, 0.010619648732244968, 0.008435339666903019, 0.04942544177174568, 0.06673885136842728, -0.05486375093460083, -0.037694886326789856, -0.053407132625579834, -0.008381052874028683, -0.04684052988886833, -0.049631137400865555, -0.05397925153374672, -0.06288813799619675, 0.0025069559924304485, -0.01989944837987423, 0.028846731409430504, 0.02329884096980095, -0.03569071739912033, -0.07159870117902756, 0.023103615269064903, -0.06755144894123077, 0.03380962088704109, 0.06194940209388733, 0.0011643540346994996, 0.013106366619467735, 0.03839944675564766, -0.018302815034985542, 0.011769898235797882, -0.012975192628800869, -0.020525652915239334, 0.034710101783275604, 0.10544106364250183, 0.07390110194683075, 0.023822417482733727, -0.09718696027994156, -0.00650765048339963, 0.0124506251886487, -0.030531389638781548, -0.03366520628333092, -0.02116268128156662, 3.7503945224893535e-33, 0.04823395237326622, 0.06420905143022537, 0.011028642766177654, 0.0639272928237915, 0.027343515306711197, -0.007699549198150635, -0.05527181178331375, -0.049707021564245224, 0.03061337023973465, 0.0894368588924408, -0.10023070871829987, -0.00797024555504322, 0.05174443870782852, 0.08683288097381592, -0.048290666192770004, -0.05616890639066696, -0.02759878896176815, 0.07711787521839142, -0.047854259610176086, -0.0019069293048232794, 0.004928188398480415, 0.13663853704929352, 0.015170001424849033, -0.001353418454527855, -0.03696632757782936, 0.005810696166008711, -0.056156303733587265, -0.005849927198141813, -0.00972715113312006, -0.005981214344501495, 0.05025147646665573, -0.04337215796113014, -0.035282161086797714, -0.045978665351867676, -0.054050907492637634, -0.015683308243751526, -0.012727800756692886, 0.017310824245214462, 0.015051616355776787, 0.016558175906538963, -0.040182746946811676, 0.06206466630101204, 0.03905455023050308, 0.06617920100688934, 0.038614220917224884, -0.05270500108599663, -0.020689187571406364, 0.0058549391105771065, -0.00284197018481791, -0.02532694861292839, -0.013086313381791115, 0.014930942095816135, 0.06581491976976395, -0.037772782146930695, -0.04307274892926216, 0.014199325814843178, -0.041562095284461975, 0.016063136979937553, 0.01964857056736946, 0.11718679219484329, -0.01367440540343523, 0.0574113205075264, -0.04411410540342331, -0.0756770521402359, -0.02446362003684044, -0.01826191134750843, -0.17128948867321014, -0.07453913241624832, 0.012947400100529194, 0.035431668162345886, -0.05869145318865776, 0.0007713050581514835, 0.05452590435743332, 0.029537566006183624, 0.06272436678409576, 0.07783877104520798, 0.03388682380318642, -0.051284704357385635, -0.10174674540758133, -0.06000924110412598, -0.03478560596704483, -0.06190994754433632, -0.022656725719571114, -0.019012564793229103, 0.020274467766284943, -0.017980050295591354, -0.011966584250330925, -0.053777728229761124, 0.005036346148699522, 0.00499579356983304, -0.008671291172504425, -0.044408876448869705, -0.02921326830983162, -0.051031168550252914, -0.13437402248382568, -3.798608892656268e-33, -0.01060477551072836, 0.059732336550951004, -0.015791667625308037, -0.020524345338344574, 0.012396256439387798, 0.02769606001675129, 0.008779221214354038, 0.009821792133152485, 0.03946689888834953, -0.044304948300123215, 0.07479051500558853, 0.007743640802800655, -0.07089702039957047, -0.0950705036520958, -0.028545575216412544, 0.09060335159301758, -0.05373669043183327, 0.07921822369098663, -0.039992425590753555, -0.039981208741664886, -0.062377944588661194, 0.06743470579385757, -0.05655907839536667, 0.062289029359817505, 0.03908782824873924, 0.09458333998918533, -0.06239689514040947, -0.03141430392861366, 0.064284548163414, 0.08715886622667313, 0.002261710586026311, -0.07377160340547562, -0.04059794545173645, 0.05891016498208046, -0.032312896102666855, 0.0118759386241436, -0.04305101931095123, -0.041613783687353134, -0.02179092727601528, 0.05092332139611244, 0.11736118048429489, -0.059598159044981, 0.10013898462057114, 0.006068288814276457, 0.04656447470188141, -0.015089156106114388, -0.06831692159175873, -0.10720615833997726, -0.08420837670564651, 0.026285231113433838, 0.06574899703264236, 0.04174123331904411, -0.07921955734491348, 0.07346180826425552, 0.11143573373556137, -0.04179266467690468, -0.000005980248715786729, -0.06208224594593048, -0.07062375545501709, -0.0687071830034256, 0.00011318317410768941, 0.0002403641410637647, 0.03693961352109909, 0.0031999635975807905, 0.05246527120471001, -0.019627442583441734, -0.049006387591362, -0.04273197799921036, 0.015355842188000679, -0.01854884810745716, 0.012506820261478424, 0.022194717079401016, -0.02458038181066513, -0.1358388215303421, 0.04176487401127815, 0.003114726161584258, 0.07364150136709213, -0.034034613519907, -0.043419837951660156, 0.024646537378430367, -0.062480196356773376, -0.014610223472118378, 0.036295004189014435, -0.005638930946588516, 0.006521148141473532, 0.029292868450284004, 0.04075279086828232, 0.04076259210705757, 0.0456833578646183, 0.027413520961999893, -0.010262557305395603, 0.006162057165056467, 0.024216247722506523, 0.06366248428821564, 0.12686485052108765, -5.1470060213887336e-8, 0.041238896548748016, -0.026482699438929558, 0.02964211069047451, 0.018328119069337845, -0.0010670052142813802, -0.03787323832511902, 0.015318489633500576, 0.043363869190216064, -0.030116833746433258, -0.04254375398159027, 0.0438491590321064, 0.10253041982650757, 0.007259204983711243, -0.056484874337911606, 0.05732227861881256, -0.007185334339737892, -0.02349528856575489, 0.14468200504779816, -0.021507233381271362, -0.11133590340614319, -0.05122077465057373, 0.024569839239120483, -0.014004236087203026, 0.01965082623064518, -0.016228094696998596, -0.04435000941157341, 0.0032071692403405905, -0.02788745053112507, 0.03651329502463341, 0.02675134316086769, 0.06306929886341095, -0.0680982768535614, 0.005443651229143143, -0.04340576380491257, 0.02008775994181633, 0.047778114676475525, 0.004412159789353609, -0.04745703935623169, -0.008401385508477688, 0.11480678617954254, -0.11924584209918976, -0.06809188425540924, -0.01877250336110592, 0.08940541744232178, 0.03989274054765701, -0.06802521646022797, -0.06139091029763222, 0.04994175210595131, 0.060200855135917664, -0.12183830887079239, 0.010825429111719131, 0.025134891271591187, -0.030712222680449486, -0.0196407251060009, -0.04550868645310402, 0.07746779173612595, 0.006918582133948803, -0.01828349009156227, -0.03265022486448288, 0.011147331446409225, 0.027477925643324852, 0.03504418954253197, 0.07677846401929855, -0.03367879241704941 ]
Improves\tstrength,\npower,\tand\nIncreases\tmuscle\tfree\tcreatine,\nphosphocreatine;\tperformance\nWeight\tgain\n0.8%-2.9%;
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intermittent\tsprint\nperformance;\naccelerates\ttraining\nrecovery\neffect\tseen\tin\tsprint/power\tthrough\nendurance\tby\tenhancing\tmuscle\nglycogen\tstorage;\tstimulates\nmuscle\tanabolism,\tmuscle\nrelaxation;\teffects\tmay\tfade\tafter\t2\nmonths\tsupplementation;\tconsume\nwith\tCHO\tto\tincrease\tlevels\tto\ngreater\textent\nwatch\twith\nweight-\nsensitive\nsports;\nunknown\tlong
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greater\textent\nwatch\twith\nweight-\nsensitive\nsports;\nunknown\tlong\nterm\nALA\n,\tα-Lipoic\tacid;\t\nATP\n,\tadenosine\ttriphosphate;\t\nBM\n,\tbody\tmass;\t\nCF\n,\tcardiorespiratory\tfitness;\t\nCHO\n,\tcholesterol;\t\nCK,\n\tcreatine\tkinase;\t\nDOMS\n,\ndelayed\tonset\tmuscle\tsoreness;\t\nEAA\n,\tessential\tamino\tacid;\t\nGH\n,\tgrowth\thormone;\t\nGI\n,\tgastrointestinal;\t\nHIIT
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GH\n,\tgrowth\thormone;\t\nGI\n,\tgastrointestinal;\t\nHIIT\n,\thigh-intensity\tinterval\ttraining;\t\nHGH\n,\nhuman\tgrowth\thormone;\t\nHMB\n,\tβ-hydroxy-β-methylbutyrate;\t\nIL-8\n,\tinterleukin-8;\t\nLDL\n,\tlow-density\tlipoprotein;\t\nNO\n,\tnitric\toxide;\t\nTBI\n,\ttraumatic\tbrain\ninjury;\t\nTNF-\nα:\ttumor\n\tnecrosis\tfactor\talpha;\t\nURTI\n,\tupper\trespiratory\ttract\tinfection.\nB\tvitamins
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URTI\n,\tupper\trespiratory\ttract\tinfection.\nB\tvitamins\nIncreased\tenergy\tmetabolism\tcreates\ta\tneed\tfor\tmore\tof\tthe\tB\tvitamins,\tincluding\tthiamin,\nriboflavin,\tniacin,\tpyridoxine,\tfolate,\tbiotin,\tpantothenic\tacid,\tand\tcholine,\twhich\tserve\tas\tpart\tof\ncoenzymes\tinvolved\tin\tregulating\tenergy\tmetabolism\tby\tmodulating\tthe\tsynthesis\tand\tdegradation\tof
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carbohydrates,\tprotein,\tfat,\n\tand\tbioactive\tcompounds.\nSome\tathletes\twho\thave\tpoor\tdiets,\tand\tathletes\tsuch\tas\twrestlers,\tjockeys,\tfigure\tskaters,\ngymnasts,\tor\trowers\twho\tconsume\tlow-calorie\tdiets\tfor\tlong\tperiods\tof\ttime\tmay\tbe\tprone\tto\ndeficiencies.\tA\tB-complex\tvitamin\tsupplement\tto\tmeet\tthe\tRDA\tmay\tbe\tappropriate\t(\nThomas\tet\tal,\n2016
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Thomas\tet\tal,\n2016\n).\tHowever,\tthere\tis\tno\tevidence\tthat\tsupplementing\tthe\twell-nourished\tathlete\twith\tmore\n\tB\nvitamins\tincreases\tperformance.\nThe\tintake\tof\tfolate\tcould\tpotentially\tbe\tlow\tin\tathletes\twhose\tconsumption\tof\twhole\tgrains,\twhole\nfruits,\tand\tvegetables\tis\tlow.\tLikewise\ta\tdeficiency\tof\tvitamin\tB\n12\n\tcould\tdevelop\tin\ta\tvegetarian
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12\n\tcould\tdevelop\tin\ta\tvegetarian\nathlete\tafter\tseveral\tyears\tof\ta\tstrict\tvegan\tintake;\tthus\ta\tvitamin\tB\n12\n\tsupplement\tmay\tbe\twarranted.\nHowever,\twhile\tcorrecting\tfolate\tand\tvitamin\tB\n12\n\tdeficiencies\n\twith\ta\tsupplement\tmay\tbe\twarranted\nfor\ta\tsafeguard\tfor\thealth,\tsupplementation\tfor\teither\tvitamin\thas\tnot\tbeen\tshown\tto\timprove\nperformance.
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performance.\nAntioxidants\nAntioxidants\thave\tbeen\tstudied\tindividually\tand\tcollectively\tfor\ttheir\tpotential\tto\tenhance\texercise\nperformance\tor\tto\tprevent\texercise-induced\tmuscle\ttissue\tdamage.\tCells\tcontinuously\tproduce\tfree\nradicals\tand\t\nreactive\toxygen\tspecies\t(ROS)\n\tas\ta\tpart\tof\tmetabolic\tprocesses.\tThe\trate\tof\tVO\n2
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Chapter\t7\n).\nFree\tradicals\tare\tneutralized\tby\tantioxidant\n\tdefense\tsystems\tthat\tprotect\tcell\tmembranes\tfrom\noxidative\tdamage.\tThese\tsystems\tinclude\tcatalase;\tsuperoxide\tdismutase;\tglutathione\tperoxidase;\nantioxidant\tvitamins\tA,\tE,\tand\tC;\tselenium;\tand\tphytonutrients\tsuch\tas\tcarotenoids\t(see\t\nChapter\t7\n).
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Chapter\t7\n).\nSusceptibility\tto\toxidative\tstress\tvaries\tfrom\tperson\tto\tperson,\tand\tthe\teffect\tis\tinfluenced\tby\tdiet,\nlifestyle,\tenvironmental\tfactors,\tand\ttraining.\n\tAntioxidant\tnutrients\tmay\tenhance\trecovery\tfrom\nexercise\tby\tmaintaining\toptimal\timmune\tresponse\tand\tlowering\tlipid\tperoxidation.
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Although\tlarge-dose\tantioxidant\tsupplementation\tattenuates\texercise-induced\tROS\tproduction\tand\nconsequential\toxidative\tdamage,\tstudies\tsuggest\toversupplementation\tmay\tblock\tnecessary\tcellular\nadaptations\tto\texercise\t(\nSureda\tet\tal,\t2013\n).\tFurther\tresearch\tis\tneeded\tto\n\tassess\tthe\tresponse\tto
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).\tFurther\tresearch\tis\tneeded\tto\n\tassess\tthe\tresponse\tto\nsupplementation\twith\tvarying\tdegrees\tof\texercise\tduration\tand\tintensity\t(\nSureda\tet\tal,\t2013\n).\nA\tdiet\trich\tin\tfruits\tand\tvegetables\tcan\tensure\tan\tadequate\tintake\tof\tantioxidants,\tand\tprudent\tuse\nof\tan\tantioxidant\tsupplement\tmay\tprovide\tinsurance\tagainst\ta\tsuboptimal\tdiet\tand\tthe\tincreased
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stress\tfrom\texercise.\tResearch\thas\talso\tshown\tthe\tpositive\tbenefits\tof\tphytonutrients\n\twith\nantiinflammatory\tand\tantioxidant\teffects,\twhich\tmay\thelp\twith\tposttraining\tinflammation.\tExamples\ninclude\tanthocyanins\tin\tpurple\tand\tred\tfruits\tand\tvegetables,\tand\tquercetin\tfound\tin\tred\tonions,
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-0.09698101878166199, 0.01199230644851923, -0.0008457545773126185, 0.054677098989486694, 0.0710468739271164, -0.09195408970117569, -0.028781605884432793, 0.07103075087070465, -0.005007124040275812, -0.06427309662103653, -0.028960227966308594, 0.052195195108652115, 0.016889963299036026, 0.007333578076213598, -0.04276620224118233, 0.056939106434583664, 0.08816307783126831, 0.048533838242292404, -0.03132620081305504, -0.024954428896307945, 0.02275458537042141, 0.05309407785534859, 0.09631497412919998, 0.0049865590408444405 ]
blueberries,\ttomatoes,\tapples,\tblack\ttea,\tand\tpurple\tgrapes.\tCompounds\tfound\tin\ttart\tcherry\tjuice\nhelp\tto\treduce\tinflammation,\tmuscle\tdamage,\tand\toxidative\tstress\t(\nRawson\tet\tal,\t2018\n).\nVitamin\tD\nOver\tthe\tpast\tfew\tyears,\tvitamin\tD\thas\tbeen\tshown\tto\tplay\tan\tincreasingly\timportant\trole\tin\tsports
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performance\tbeyond\tits\trole\tin\tcalcium\tabsorption\tand\tuse\tin\tbone\tformation\t(\nTodd\tet\tal,\t2015\n).\tAs\ta\nsecosteroid\thormone,\tupon\tactivation\tto\t1,25-hydroxy\tvitamin\tD\n3\n,\tvitamin\tD\tresponsive\tgene\nexpression\tis\taltered\twith\tmore\tthan\t1000\tresponsive\tgenes\taffecting\tMPS,\tmuscle\tstrength,\tmuscle\nsize,\treaction
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size,\treaction\n\ttime,\tbalance\tcoordination,\tendurance,\tinflammation,\tand\timmunity,\tall\tof\twhich\tare\nimportant\tto\tathletic\tperformance\t(\nBox\t22.6\n).\nBOX\t22.6\nVitamin\tD\tand\tAthletic\tPerformance\nVitamin\tD\tpotential\timpact\ton\tathletic\tperformance\nPositive\teffect\ton\tmuscle\tstrength,\tpower,\tand\tmass
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Positive\teffect\ton\tmuscle\tstrength,\tpower,\tand\tmass\nIncreased\tforce\tand\tpower\toutput\tof\tskeletal\tmuscle\ttissue\nMay\tinfluence\tmaximal\toxygen\tuptake\t(VO\n2\nmax)
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Improved\tskeletal\tmuscle\tfunction\tand\tbone\tstrength\nPotentially\tincreased\tsize\tand\tnumber\tof\ttype\tII\tmuscle\tfibers\nDecreased\trecovery\ttime\tfrom\ttraining\nIncrease\ttestosterone\tproduction\nFrom\tDahlquist\tDT\tet\tal:\tPlausible\tergogenic\teffects\tof\tvitamin\tD\ton\tathletic\tperformance\tand\trecovery,\t\nJ\nInt\tSoc\tSports\tNutr\n,\t12:33,\t2015.
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J\nInt\tSoc\tSports\tNutr\n,\t12:33,\t2015.\nVitamin\tD\tdeficiency\tmay\tbe\tmore\tcommon\tin\tathletes\tthan\tpreviously\n\tthought,\tespecially\tin\nspecific\tgroups\t(\nShuler\tet\tal,\t2012\n).\tThe\tprevalence\tappears\tto\tvary\tby\tsport,\ttraining\tlocation,\ttime\nof\tyear,\tand\tskin\tcolor\t(\nRawson\tet\tal,\t2018\n).\tResearch\thas\tshown\tthat\tmore\tthan\t75%\tof\tCaucasians
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).\tResearch\thas\tshown\tthat\tmore\tthan\t75%\tof\tCaucasians\nand\t90%\tof\tAfrican\tAmericans\tand\tLatinos\tare\tpossibly\tvitamin\tD\tdeficient\taccording\tto\tset\tvalues.\tIt\nis\tpossible\tthat\tup\tto\t77%\tof\tathletes\twho\tlive\tin\tnorthern\tclimates\twith\n\tlittle\twinter\tsunlight\tand\nwho\tare\tindoor\tathletes\t(94%\tof\tbasketball\tplayers\tand\t83%\tof\tgymnasts)\tmay\tbe\taffected\tby
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deficiencies\tof\tvitamin\tD\t(\nSikora-Klak\tet\tal,\t2018\n).\tOne\trecent\tstudy\tshowed\tvitamin\tD\tdeficiency\tis\nquite\tcommon\tamong\tNational\tBasketball\tAssociation\t(NBA)\tDraft\tCombine\tparticipants,\taffecting\n73.5%\t(\nGrieshober\tet\tal,\t2018\n).\tOutdoor\tathletes\tmay\tnot\thave\tan\tadvantage\tover\tindoor\n\tathletes;\tin
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athletes;\tin\na\tNational\tFootball\tLeague\t(NFL)\tstudy,\t81%\tof\tCaucasian\tand\tAfrican\tAmerican\tplayers\tmay\tbe\tat\nrisk\tfor\tdeficiency.\tBlood\ttests\tcan\tbetter\tdetermine\tdeficiency\tstates.\nAlthough\tthe\tspecific\tamount\tof\tvitamin\tD\tneeded\tto\treverse\tdeficiency\tstates\thas\tnot\tbeen
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determined,\tpartly\tbecause\tit\tdepends\ton\tthe\textent\tof\tdeficiency,\tathletes\tshould\tbe\ttested\tand\nguided\tby\ta\thealth\tprofessional\n\tif\tdiagnosed\twith\ta\tdeficiency\t(see\t\nChapter\t5\n\tand\t\nAppendices\t12\n\tand\n38\n).\nAfter\ta\tdetailed\tassessment,\trecommendations\tfor\tattaining\tand\tmaintaining\toptimal\tvitamin\tD
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levels\tcan\tbe\tindividualized\tto\tthe\tathlete’s\tcurrent\t25(OH)D\tconcentration,\tdietary\tintake,\tlifestyle\nhabits\tand\tclinical\tsymptoms.\tThe\trecommendation\tfor\tfair-skinned\tindividuals\tis\tto\tobtain\t5\tminutes\nand\tfor\tdark-skinned\tindividuals,\n\t30\tminutes\tof\tsunlight\texposure\tto\tarms,\tlegs,\tand\tback\tseveral\ntimes\ta\tweek\twithout\tsunscreen\t(see
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times\ta\tweek\twithout\tsunscreen\t(see\t\nAppendix\t38\n).\tShort-term,\thigh-dose\t“loading”\tregimens\tfor\nrapid\trepletion\tunder\tthe\tcare\tof\ta\tphysician\talso\tmay\tbe\tbeneficial\t(\nTodd\tet\tal,\t2015\n).\nMinerals\nAlthough\t12\tminerals\thave\tbeen\tshown\tto\tbe\tdesignated\tas\tessential\tnutrients,\tiron,\tcalcium,\nmagnesium,\tand\tcopper\thave\tbiochemical\tfunctions
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magnesium,\tand\tcopper\thave\tbiochemical\tfunctions\n\twith\tthe\tpotential\tto\taffect\tathletic\tperformance.\nIron\nIron\tis\tcritical\tfor\tsport\tperformance\tbecause,\tas\ta\tcomponent\tof\themoglobin,\tit\tis\tinstrumental\tin\ntransporting\toxygen\tfrom\tthe\tlungs\tto\tthe\ttissues.\tIt\tperforms\ta\tsimilar\trole\tin\t\nmyoglobin\n,\twhich
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(see\t\nChapter\t31\n).\nSports\tanemia\n\tis\ta\tterm\tapplied\tto\tat\tleast\tthree\tdifferent\tconditions:\themodilution,\tiron\ndeficiency\tanemia,\tand\tfoot-strike\tanemia.\tAthletes\tat\trisk\tare\tthe\trapidly\tgrowing\tmale\tadolescent;\nthe\tfemale\tathlete\twith\theavy\tmenstrual\tlosses;\tthe\tathlete\twith\tan\tenergy-restricted\tdiet;\tdistance
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runners\twho\tmay\thave\tincreased\tGI\tiron\tloss,\thematuria,\themolysis\tcaused\tby\tfoot\timpact,\n\tand\nmyoglobin\tleakage;\tand\tthose\ttraining\twith\theavy\tsweating\tin\thot\tclimates.\tRecent\tresearch\nsuggests\tthat\tanemia\tmay\tbe\tcommon\tin\tfemale\tathletes,\tespecially\tadolescent\tand\tpremenopausal
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0.07914222031831741, 0.012084069661796093, 0.01589537039399147, 0.038627948611974716, -4.738979342278071e-8, -0.047835517674684525, 0.001515036216005683, 0.0048261163756251335, 0.0078047639690339565, 0.07208990305662155, 0.009937381371855736, 0.0642211064696312, -0.009070501662790775, 0.0018778613302856684, -0.06921662390232086, 0.049429550766944885, 0.06643033772706985, -0.038703616708517075, -0.03426620736718178, 0.09178266674280167, 0.008375898003578186, 0.02332913689315319, 0.11786505579948425, -0.03662233427166939, -0.050661541521549225, 0.026314247399568558, 0.06254862993955612, -0.06435970962047577, -0.013024433515965939, -0.09454331547021866, 0.030484244227409363, -0.05841107293963432, 0.0268603153526783, -0.02200431004166603, 0.039853692054748535, 0.054997265338897705, -0.006881535518914461, -0.0031424083281308413, -0.0868714228272438, -0.02843412756919861, 0.07452037185430527, -0.09092198312282562, -0.0620381198823452, 0.02016325108706951, 0.12261725962162018, -0.01766566000878811, -0.006727670785039663, -0.026673629879951477, 0.12530574202537537, 0.05117412284016609, -0.024410396814346313, 0.008043109439313412, 0.011753964237868786, 0.009473320096731186, -0.03199494257569313, -0.03763316199183464, 0.07576236128807068, 0.02639174833893776, -0.026799358427524567, -0.029398113489151, 0.03307211399078369, 0.0684012845158577, 0.012460987083613873, -0.014011484570801258, 0.045300208032131195, 0.0880228579044342, 0.04583200439810753, 0.03411981090903282, -0.01512804627418518 ]
iron\tdeficiency\tin\t60%\tof\tfemale\ttriathletes,\t55.6%\tof\tfemale\trunners,\t37.5%\tof\tmale\ttriathletes,\tand\n31.3%\tof\tmale\trunners\tcompared\twith\tvalues\treported\tfor\tendurance\tathletes\t(20%\tto\t50%\tfemales,\n0%\tto\t17%\tmales)\t(\nCoates\tet\tal,\t2017\n).\tIn\tanother\tstudy\tof\t2749\tcollegiate\tathletes,\t2.2%\tof\tfemales\nindicated
[ -0.0009369011968374252, -0.007926871068775654, -0.02007342502474785, 0.07091990858316422, -0.020280973985791206, -0.007970714941620827, 0.11045356094837189, 0.037352386862039566, -0.059264443814754486, 0.00860358402132988, 0.024126136675477028, -0.05782264471054077, 0.01322706788778305, 0.019041435793042183, -0.06068376079201698, -0.07200560718774796, 0.00982639379799366, 0.01548163965344429, -0.09808032959699631, -0.007650537416338921, 0.0023459126241505146, -0.028803138062357903, 0.048869915306568146, -0.013631988316774368, -0.002492510713636875, -0.012359172105789185, -0.024536214768886566, 0.02450750768184662, -0.037192996591329575, -0.05259793996810913, -0.11892981827259064, 0.025711525231599808, -0.006690980866551399, -0.03820235654711723, 0.008962980471551418, 0.0016979012871161103, -0.07659520953893661, 0.0013621997786685824, -0.044538404792547226, 0.0362616702914238, -0.03002992644906044, -0.1135488823056221, -0.03330690413713455, 0.02361505664885044, 0.025349287316203117, 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0.020916100591421127, 0.01614811271429062, 0.04138122498989105, 0.008699401281774044, 0.012657271698117256, 0.012339167296886444, -0.0033182166516780853, -0.0020155999809503555, 0.016059834510087967, 0.12400207668542862, -0.008691657334566116, -0.03972379490733147, -0.09795024245977402, -0.05640173330903053, 0.06385944783687592, 0.003033821005374193, 0.07136651873588562, -0.043649859726428986, -0.06368330121040344, -0.05404602736234665, 0.04519698768854141, -0.04208153113722801, 0.07226737588644028, -0.005051303189247847, 0.043271660804748535, -0.05904384329915047, -0.04853878170251846, 0.01429628487676382, 0.06640356034040451, 0.05237957462668419, -0.06374488770961761, 0.0074532972648739815, -0.008688006550073624, -0.077928826212883, -0.033973753452301025, 0.04215153306722641, 0.04942408204078674, 0.00835411623120308, 0.08749081194400787, 0.059955328702926636, -0.04389914870262146, 0.06259506940841675, 0.07203054428100586, 0.009156392887234688, -0.05075749754905701, -0.04082176089286804, -0.06905724108219147, 0.012164754793047905, 0.04814537614583969, 0.09125649929046631, 0.010054348036646843, -0.03911210969090462, 0.0284553375095129, 0.04854385554790497, -0.017790107056498528, 0.007469677831977606, -0.08146879076957703, -0.1016286239027977, 0.01657954789698124, -0.029105134308338165, 0.046813175082206726, 0.10794758051633835, 0.002317587146535516, 0.11846855282783508, -0.017944850027561188, -0.09738841652870178, 0.023852858692407608, -0.04870467633008957, 0.005302809178829193, 0.010382895357906818, 0.002661880338564515, -0.02168322540819645, -0.1606398969888687, 0.08113770931959152, -0.04055764526128769, 0.08357575535774231, 0.07476716488599777, -0.030968697741627693, 0.019090281799435616, -0.07045142352581024, -0.04061443731188774, 0.02447533793747425, 0.007687706034630537, 0.004960003774613142, -0.03097522258758545, 0.007237509824335575, 0.001094156876206398, -0.009493071585893631, 0.06371916830539703, -0.04312703758478165, -0.0374457947909832, 0.08095311373472214, 0.05072762444615364, 0.05412110313773155, -4.708621759164089e-8, 0.01462075300514698, -0.013500181958079338, -0.028820395469665527, 0.040763579308986664, 0.030862171202898026, 0.026687689125537872, 0.0033167016226798296, 0.022328486666083336, -0.03034166246652603, -0.03579171746969223, 0.06293708831071854, 0.06476790457963943, -0.04304727911949158, -0.04943949356675148, 0.039281319826841354, -0.0022755414247512817, -0.022102897986769676, 0.14376609027385712, -0.0712500587105751, -0.05084177479147911, 0.041656408458948135, 0.07707013189792633, 0.03468291461467743, -0.010472172871232033, 0.00011074001668021083, -0.032674867659807205, -0.06030694767832756, -0.001620013266801834, 0.04757644608616829, 0.05551689863204956, -0.01529916562139988, -0.06724174320697784, 0.048266198486089706, -0.006281564477831125, -0.007705803029239178, 0.0567239373922348, -0.06678733974695206, 0.0017879988299682736, -0.07538124173879623, 0.1051056906580925, -0.11233151704072952, -0.04306698217988014, -0.018409790471196175, 0.08698975294828415, 0.07445720583200455, -0.10847321897745132, -0.1114063635468483, 0.07198190689086914, 0.00039496395038440824, -0.08613025397062302, -0.016321560367941856, 0.05688519775867462, 0.05880333483219147, 0.014831949956715107, -0.01683344691991806, 0.09464086592197418, 0.03201572597026825, -0.008210779167711735, -0.014984611421823502, 0.03547902777791023, 0.07323188334703445, -0.045135751366615295, -0.0033247037790715694, -0.01537935808300972 ]
indicated\n\tiron\tdeficiency\tanemia\tand\t30.9%\tindicated\tiron\tdeficiency\twithout\tanemia.\tFor\tmale\nathletes,\t1.2%\tindicated\tiron\tdeficiency\tanemia\tand\t2.9%\tindicated\tiron\tdeficiency\twithout\tanemia\n(\nParks\tet\tal,\t2017\n)\nHeavy\tendurance\ttraining\talso\tcan\tcause\ta\ttransient\tdecrease\tin\tserum\tferritin\tand\themoglobin.\nThis\tcondition,\tknown\tas\t\npseudoanemia
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This\tcondition,\tknown\tas\t\npseudoanemia\n,\tis\tcharacterized\tby\treduced\themoglobin\tlevels\tresulting\nfrom\n\texpanding\tblood\tvolumes\tthat\tare\talmost\tthose\tof\tclinical\tanemia\tbut\treturn\tto\tpretraining\nnormal\tlevels.\tPerformance\tdoes\tnot\tappear\tto\tdeteriorate\tand\tthe\tpseudoanemia\tmay\tin\tfact\nimprove\taerobic\tcapacity\tand\tperformance\t(\nMcArdle\tet\tal,\t2014
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improve\taerobic\tcapacity\tand\tperformance\t(\nMcArdle\tet\tal,\t2014\n).\nSome\tathletes,\tespecially\tlong-distance\trunners,\texperience\tGI\tbleeding\tthat\tis\trelated\tto\tthe\nintensity\tand\tduration\tof\tthe\texercise,\tthe\tathlete’s\n\tability\tto\tstay\thydrated,\thow\twell\tthe\tathlete\tis
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ability\tto\tstay\thydrated,\thow\twell\tthe\tathlete\tis\ntrained,\tand\twhether\tthey\thave\ttaken\tibuprofen\tbefore\tthe\tcompetition.\tIron\tloss\tfrom\tGI\tbleeding\ncan\tbe\tdetected\tby\tfecal\themoglobin\tassays.\nIt\tis\tpossible\tthat\tusing\tserum\themoglobin\tas\tthe\tdetermining\tfactor\tfor\tidentifying\tanemic
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athletes\twho\tmay\tbenefit\tfrom\tiron\tsupplementation\twith\tperformance\timprovement\tis\tnot\tthe\tbest\nbiomarker.\tNonanemic\n\tathletes\t(with\tnormal\tserum\themoglobin)\twho\tare\tsupplemented\twith\tiron\nhave\tshown\timproved\tperformance.\tOptimal\tlevels\tof\tserum\tferritin,\twhich\tis\tthe\tmost\tcommon
[ 0.028167933225631714, -0.029523873701691628, 0.054314110428094864, -0.07495035976171494, -0.09081684052944183, 0.047028567641973495, 0.08943335711956024, 0.030209345743060112, -0.013251082971692085, 0.08169735223054886, 0.0556667223572731, -0.0742374062538147, 0.02134401910007, 0.04244212806224823, -0.03687511757016182, -0.021794039756059647, -0.019147560000419617, 0.053231798112392426, -0.05685651674866676, -0.06322816014289856, 0.02070268616080284, 0.07110645622015, 0.05564841255545616, 0.03159618005156517, 0.05193855240941048, 0.0032111206091940403, -0.09270074218511581, 0.012018448673188686, 0.030355464667081833, -0.0035797939635813236, -0.20666246116161346, -0.00979107990860939, 0.0646943673491478, 0.04587145522236824, -0.026516059413552284, 0.027004290372133255, -0.02535925805568695, 0.04542431980371475, 0.012875929474830627, 0.03059943951666355, 0.02310420200228691, -0.0935308039188385, -0.028789618983864784, 0.03778184950351715, 0.02311239205300808, 0.046088915318250656, 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0.01779862679541111, 0.07651730626821518, 0.057119324803352356, -5.112540790719322e-8, 0.002233377657830715, -0.024253448471426964, -0.009050539694726467, 0.024312853813171387, 0.017812669277191162, 0.004051697440445423, 0.012527680955827236, 0.04175107553601265, 0.025343874469399452, -0.010424355044960976, 0.07743711769580841, 0.029780635610222816, -0.07738006860017776, -0.04919488728046417, 0.10387058556079865, -0.0022654614876955748, -0.02060961164534092, 0.08669321984052658, -0.05485749617218971, -0.05362463369965553, -0.023260151967406273, 0.05152836814522743, -0.019339635968208313, 0.0003426024632062763, -0.041489630937576294, 0.008513561449944973, -0.06502243131399155, -0.00017593229131307453, -0.005694899708032608, 0.020858071744441986, 0.04942357540130615, 0.0008281100890599191, 0.0031815071124583483, -0.08014261722564697, -0.03636619821190834, 0.02088126540184021, -0.01183445006608963, -0.03324475511908531, -0.03501977398991585, 0.09867687523365021, -0.0022236397489905357, -0.04095901921391487, -0.014097882434725761, 0.09828180074691772, 0.10641507059335709, -0.07837727665901184, -0.016058368608355522, 0.0988641306757927, -0.011632070876657963, -0.09721356630325317, -0.047000374644994736, 0.07196416705846786, 0.03051711432635784, -0.05675018951296806, -0.05970708280801773, 0.06434465944766998, 0.04934927821159363, 0.00021924800239503384, -0.017462976276874542, -0.005386332981288433, 0.11271905153989792, 0.05177862569689751, 0.01839642971754074, 0.0005780779174529016 ]
index\tof\tbody\tiron\tstatus\tassociated\twith\tperformance,\tand\tthus\ta\tbetter\tmarker,\tmay\talso\tbe
[ 0.07246310263872147, -0.036581940948963165, -0.013854969292879105, -0.007744715083390474, -0.01695387437939644, 0.008230041712522507, 0.11464779078960419, -0.024463040754199028, 0.005637295078486204, 0.04552365839481354, 0.061087463051080704, 0.011775089427828789, 0.05505147948861122, 0.0032401783391833305, -0.0661078691482544, -0.04379652813076973, -0.04998460039496422, 0.04573580622673035, -0.016002604737877846, -0.0646510124206543, 0.037096887826919556, 0.09274756908416748, -0.04761546850204468, 0.001797644654288888, 0.0018679852364584804, 0.0033862870186567307, -0.042356204241514206, -0.035294435918331146, 0.044592324644327164, -0.00026972664636559784, -0.15838903188705444, 0.06604065001010895, -0.004493911284953356, 0.05843066796660423, -0.05429088696837425, 0.000019654547941172495, 0.00919978879392147, -0.014115756377577782, 0.05845312029123306, 0.011794893071055412, -0.04060903936624527, -0.043676745146512985, -0.02504497580230236, 0.022642556577920914, 0.06635622680187225, 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inadequate,\tbecause\tathletes\tsupplemented\twith\tiron\tto\tachieve\thigher\tthan\t“normal”\tserum\tferritin\nlevels\thave\talso\tshown\timproved\tperformance\n\t(\nDellaValle,\t2013\n).\tSome\tathletes\texperience\tiron\ndeficiency\twithout\tanemia\tand\thave\tnormal\themoglobin\tlevels\tbut\treduced\tlevels\tof\tserum\tferritin\n(20\tto\t30\tng/mL;\tsee\t\nChapter\t5\n).
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(20\tto\t30\tng/mL;\tsee\t\nChapter\t5\n).\nAthletes\tshould\tbe\tassessed\tfor\ttheir\tiron\tstatus\tusing\tserum\themoglobin\tand\tserum\tferritin\tat\tthe\nbeginning\tof\tand\tduring\tthe\ttraining\tseason.\tThis\tis\tespecially\timportant\tin\tthose\tsuspected\tto\thave\nsickle\tcell\ttrait\n\t(SCT)\tbecause\ttheir\trate\tof\tsudden\tdeath\tis\t10\tto\t30\ttimes\thigher\tthan\tin\tnon-SCT
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athletes.\tTypically\tdeaths\thave\toccurred\tearly\tin\tthe\tseason,\tduring\texhaustive\tdrills\tin\thot\tweather\nwithout\tadequate\twarmup\ttime\t(\nHarris\tet\tal,\t2012\n).\tIn\t2010\tthe\tNCAA\tinstituted\ta\tuniversal\nscreening\tprogram\tto\ttest\tfor\tSCT\tin\tall\tDivision\tI\tathletes;\thowever,\tin\tathletes\tat\tthe\thigh\tschool\nlevel,\tand\tin\tthe\tNBA,
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level,\tand\tin\tthe\tNBA,\n\tNFL,\tNavy,\tMarines,\tand\tAir\tForce,\ttesting\tis\tnot\trequired\t(\nJung\tet\tal,\t2011\n).\nAlthough\tmale\tathletes\thave\tbeen\treported\tto\tconsume\tat\tleast\tthe\tRDA\tfor\tiron,\tfemale\tathletes\ntend\tto\tconsume\tsomewhat\tless\tfor\ta\tvariety\tof\treasons,\tincluding\tlow\tenergy\tintake,\tlower\tintake\tof
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animal\tproducts,\tor\tadherence\tto\ta\tvegetarian\tor\tvegan\tdiet\t(\nRogerson,\t2017\n).\tIncreasing\tdietary\nintake\tof\tiron\tor\tsupplementation\n\tis\tthe\tonly\tway\tto\treplace\tiron\tlosses\tand\timprove\tstatus\n(\nFarrokhyar,\t2015\n).\nWho\tshould\tbe\tsupplemented\tand\twith\thow\tmuch\tiron\tremains\tto\tbe\tanswered.\tGiven\tthe\tevidence
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suggesting\tiron’s\trole\tin\toverall\thealth\tand\tphysical\tperformance,\tthere\tis\tno\tdebate\tthat\tathletes\nwith\tclinical\tdeficiency\tshould\tbe\tidentified\tand\ttreated.\tWhether\tthose\twith\tsubclinical\tdeficiency\nshould\tbe\ttreated\twith\n\tiron\tsupplementation\tremains\tcontroversial.\tIndividuals\twith\tnormal\tstatus
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typically\tdo\tnot\tbenefit\tfrom\tsupplementation,\tand\tconcerns\tregarding\tunregulated\tdoses\tand\noverload\tshould\tbe\tconsidered.\nCalcium\nSuboptimal\tlevels\tof\tdietary\tcalcium\tintake\tare\tseen\tin\tathletes.\tBecause\tlow\tlevels\tof\tcalcium\tintake\nhave\tbeen\tshown\tto\tbe\ta\tcontributing\tfactor\tin\tosteoporosis,\tyoung\tfemale\tathletes,\n\tespecially\tthose
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especially\tthose\nwho\thave\thad\tinterrupted\tmenstrual\tfunction,\tmay\tbe\tat\trisk\tfor\tdecreased\tbone\tmass.\tStrategies\tto\npromote\tthe\tresumption\tof\tmenses\tinclude\testrogen\treplacement\ttherapy,\tpromotion\tof\toptimal\nweight\tstatus,\tand\treduced\ttraining.\tRegardless\tof\tmenstrual\thistory,\tmost\tfemale\tathletes\tneed\tto\nincrease\ttheir\tcalcium,\tvitamin\tD\n3
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increase\ttheir\tcalcium,\tvitamin\tD\n3\n,\tand\tmagnesium\tintake.\tDairy\tand\tnondairy\toptions\tsuch\n\tas\nfortified\talmond,\tflax,\tand\tsoy\tbeverages,\tyogurts\tand\tcheeses,\tcalcium-fortified\tfruit\tjuices,\tand\ttofu\nmade\twith\tcalcium\tsulfate\tare\tgood\tsources\t(see\t\nAppendix\t39\n).\nMagnesium
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Appendix\t39\n).\nMagnesium\nMagnesium\tis\tan\tessential\tmineral\tthat\tsupports\tmore\tthan\t300\tenzymatic\treactions\tincluding\nglycolysis,\tfat\tand\tprotein\tmetabolism,\tand\tATP\thydrolysis,\tand\tis\ta\tregulator\tof\tneuromuscular,\nimmune,\tand\thormonal\tfunctions.\n\tAlthough\thypomagnesemia\thas\tbeen\tseen\tin\tathletes,\tpossibly
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Although\thypomagnesemia\thas\tbeen\tseen\tin\tathletes,\tpossibly\ncaused\tby\texcessive\tsweating\twhile\ttraining\tand\ttransient\tredistribution\tof\tmagnesium\tindicating\ta\nrelease\tfrom\tone\tstorage\tarea\tto\tan\tactive\tsite,\tlevels\treturn\tto\tnormal\twithin\t24\thours\tafter\texercise\n(\nMalliaropoulos\tet\tal,\t2013\n).
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(\nMalliaropoulos\tet\tal,\t2013\n).\nTrue\tmagnesium\tdeficiency\thas\tbeen\tshown\tto\timpair\tathletic\tperformance,\tcausing\tmuscle\nspasms\tand\tincreased\n\theart\trate\tand\tVO\n2\n\tduring\tsubmaximal\texercise.\tFor\tdeficient\tathletes,\nsupplemental\tmagnesium\thas\tbeen\tshown\tto\timprove\tperformance\tby\timproving\tcellular\tfunction,
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although\tin\tathletes\twith\tadequate\tstatus,\tperformance\toutcomes\tare\tmixed\t(\nKass\tet\tal,\t2013\n).\tIn\none\trecent\tstudy\twith\tfemale\tvolleyball\tplayers,\tmagnesium\tsupplementation\timproved\talactic\t(does\nnot\tproduce\tany\tlactic\tacid)\tanaerobic\n\tmetabolism,\teven\tthough\tthe\tplayers\twere\tnot\tmagnesium\ndeficient\t(\nSetaro\tet\tal,\t2014
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deficient\t(\nSetaro\tet\tal,\t2014\n).\tIn\tanother\tstudy\twith\tyoung\tmen\tparticipating\tin\ta\tstrength\ttraining\nprogram\tfor\t7\tweeks,\tdaily\tmagnesium\tintake\tof\t8\tmg/kg\tof\tbody\tweight\tresulted\tin\tincreases\tin\nmuscle\tstrength\tand\tpower,\twhereas\tmarathon\trunners\twith\tadequate\tstores\tdid\tnot\tseem\tto\tbenefit\n(\nMoslehi\tet\tal,\t2013
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(\nMoslehi\tet\tal,\t2013\n).\tAs\twith\tmost\tnutrients,\tsupplementation\n\tdoes\tnot\tseem\tto\timprove\nperformance\tin\tthose\twho\tare\tnot\tdeficient.\tFood\tsources\tof\tmagnesium\tinclude\twhole\tgrains,\tnuts,\nbeans,\tand\tleafy\tgreens.\tSee\t\nAppendix\t43\n\tfor\tsources\tof\tmagnesium.
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beans,\tand\tleafy\tgreens.\tSee\t\nAppendix\t43\n\tfor\tsources\tof\tmagnesium.\nIn\ta\t2017\tmeta-analysis,\tno\tsignificant\timprovements\tin\tthe\tsupplementation\tgroup\twere\tobserved\nregarding\tisokinetic\tpeak\ttorque\textension,\tmuscle,\tor\tmuscle\tpower,\tnor\tdoes\tthe\tevidence\tsupport\na\tbeneficial
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0.04331919178366661, 0.09440064430236816, 0.07888194173574448, -5.377224354674581e-8, -0.018748661503195763, 0.004007164388895035, 0.012338566593825817, 0.016654925420880318, 0.05183330550789833, -0.04141256958246231, 0.04402558133006096, 0.004076456185430288, 0.000595982070080936, -0.028194990009069443, 0.04324999824166298, 0.09686266630887985, -0.09065458178520203, -0.013568935915827751, 0.05978454276919365, -0.0292060524225235, -0.031795985996723175, 0.10058891773223877, -0.055812422186136246, -0.05619847774505615, 0.015847818925976753, 0.06537040323019028, 0.010356025770306587, -0.03644701838493347, 0.017606306821107864, -0.019998500123620033, -0.01965193636715412, 0.01580674573779106, 0.0813237726688385, -0.013834908604621887, 0.019960304722189903, -0.04229755699634552, -0.010670688934624195, -0.07008041441440582, -0.05481690913438797, 0.04462055861949921, -0.01773497276008129, -0.04059864208102226, -0.03750663623213768, 0.09563779085874557, -0.05278857424855232, -0.02209276519715786, -0.035794131457805634, 0.04823266714811325, 0.01015888899564743, -0.045519910752773285, -0.09352116286754608, 0.10968717187643051, -0.025508778169751167, -0.06038753688335419, -0.02873566560447216, 0.07304631918668747, 0.000584357010666281, -0.04133030027151108, -0.04246996343135834, 0.03714698180556297, 0.08550028502941132, 0.0403563566505909, 0.022171689197421074, -0.06376929581165314, 0.05828036740422249, 0.030620791018009186, 0.045753464102745056, -0.05260439217090607 ]
a\tbeneficial\n\teffect\tof\tsupplementation\ton\tmuscle\tfitness\tin\tmost\tathletes\tand\tphysically\tactive\nindividuals\twho\thave\ta\trelatively\thigh\tMg\tstatus\t(\nWang\tet\tal,\t2017\n).\nCLINICAL\tINSIGHT\nGastrointestinal\tIssues\tin\tAthletes\nGut\tissues\tare\ta\tcommon\tproblem,\taffecting\tabout\t45%\tto\t85%\tof\tathletes,\t30%\tto\t50%\ton\ta\nregular\tbasis\tand\tin\t70%\tof\trunners\t(
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regular\tbasis\tand\tin\t70%\tof\trunners\t(\nJeukendrup,\t2017a\n;\t\nKoon\tet\tal,\t2017\n;\t\nter\tSteege\tet\tal,\t2012\n).\nIssues\tcan\taffect\tthe\tupper\tGI\ttract,\tsuch\tas\treflux,\theart\tburn,\tchest\tpain,\tnausea,\tvomiting,\ngastritis,\tpeptic\tulcers,\tbleeding,\tor\t\nexercise\trelated\ttransient\tabdominal\tpain\t(ETAP)\n,\talso
[ -0.011586529202759266, -0.057399604469537735, 0.0400652214884758, -0.043057940900325775, -0.09955010563135147, 0.002386710373684764, 0.07529579102993011, 0.05024081841111183, -0.010758167132735252, 0.02443491481244564, 0.11055898666381836, -0.006804741453379393, 0.012983467429876328, 0.030091017484664917, -0.034150101244449615, -0.020279033109545708, -0.024005606770515442, 0.009301627986133099, -0.0423649325966835, -0.04561425745487213, 0.018321186304092407, 0.05676634609699249, 0.04445286840200424, 0.014970455318689346, 0.05778508633375168, 0.0049650827422738075, -0.016327522695064545, 0.04413704574108124, 0.028686873614788055, -0.061690278351306915, -0.11882776767015457, 0.04643997550010681, -0.022192463278770447, -0.030899347737431526, 0.025143150240182877, -0.00756553839892149, -0.07871903479099274, 0.019550709053874016, 0.0628139078617096, 0.05608547106385231, 0.02317909710109234, -0.10621653497219086, -0.02341846190392971, -0.00045351506560109556, 0.09049957990646362, 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exercise\trelated\ttransient\tabdominal\tpain\t(ETAP)\n,\talso\nknown\tas\t“stitches,”\tor\tthe\tlower\tGI\ttract,\tsuch\tas\tgas,\tbloating,\texcessive\turge\tto\tdefecate,\ndiarrhea,\themorrhoids,\tand\tcolitis.\nGenetic\tand\tindividualized\tdifferences,\texercise\tenvironments,\tand\tlife\n\tstressors\tcan\taffect\tthe\nathlete’s\tgut\tfunction,\t\nmicrobiome
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stressors\tcan\taffect\tthe\nathlete’s\tgut\tfunction,\t\nmicrobiome\n,\tand\ttolerance\tof\tspecific\tfoods.\tAlthough\ta\tdirect\nrelationship\tbetween\texercise\tand\tgut\tmicrobial\tcomposition\tor\tfunction\thas\tnot\tbeen\nestablished,\tthere\tare\tseveral\tmechanisms\tby\twhich\tphysical\tactivity\tmight\tmodify\tthe\tmicrobiota
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and\timpact\timmune\tstatus,\tgut\tfunction,\tthe\tincidence\tof\tupper\trespiratory\tinfections\t(URI),\nmood,\tand\n\tsports\tperformance\t(\nClark\tand\tMach,\t2017\n;\t\nFoster\tet\tal,\t2017\n;\t\nHart,\t2018\n;\t\nO’Sullivan\net\tal,\t2015\n).
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It\tappears\tthat\texercise\timpacts\tthe\tbrain-gut-microbe\taxis,\tdiet\tmicrobe\thost\tmetabolic\ninteractions,\tneuroendocrine\tand\tneuroimmune\tinteractions;\tand\tan\tindividual\tathlete’s\tresponse\nto\tphysical\tstress.\tIt\tis\tthought\tthat\tthe\tmicrobiota\tcan\tact\tlike\tan\tendocrine\torgan\tsecreting\nserotonin,\tdopamine,
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serotonin,\tdopamine,\n\tor\tother\tneurotransmitters\tthat\tcan\tmodify\tthe\tstress\tresponse\tin\tathletes.\nThere\tis\talso\tevidence\tto\tsuggest\tthat\texercise-induced\tstress,\tboth\tphysiologic\tand\temotional,\ncan\tmodulate\tthe\tcomposition\tof\tgut\tmicrobiota\tand\tvice\tversa\t(\nClark\tand\tMach,\t2017\n).
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Clark\tand\tMach,\t2017\n).\nAdditionally,\tchanges\tin\tmechanical\tforces\tseen\twith\tendurance\tsports,\t(i.e.,\tlong-distance\nrunning\tand\ttriathlon)\tinclude\taltered\tGI\tblood\n\tflow\tand\tGI\tmotility,\talong\twith\tneuroendocrine\nchanges\tfrom\ttraining.\tETAP\tmay\tbe\tpossibly\tdue\tto\tirritation\tof\tthe\tperitoneum\talthough\tgastric
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or\tdiaphragm\tischemia,\tmuscular\tcramping,\tand\tstretching\tof\tthe\tvisceral\tligaments\tof\tthe\tsolid\norgans\thave\talso\tbeen\tproposed\t(\nKoon\tet\tal,\t2017\n).\nOther\tfactors\tsuch\tas\tthe\tathlete’s\tpretraining\tand/or\tprecompetition\tdiet,\tclimate\tchanges,\ncool\tto\tvery\n\thot/humid\tconditions,\temotional\tstress\tdue\tto\tcompetition,\tdehydration,\tnonsteroidal
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have\talso\tbeen\nshown\tto\tincrease\twith\texercise\tintensity\t(\nClark\tand\tMach,\t2017\n;\t\nLamprecht\tet\tal,\t2012\n).\nEducating\tathletes\ton\tbest\tpretraining\tand\tprecompetition\tfueling;\tapplying\ta\tperiodization\ttrial\nand\terror\twith\tsimple\tplain,\tlow\tfiber,\tlow\tfat,\tspice\tfree\tsolid\tor\tliquid,\twhole\tor\tsport\tfood\twith
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0.058271270245313644, 0.06825130432844162, 0.05864311009645462, -5.325362550934187e-8, -0.04596228152513504, -0.030525492504239082, -0.011310386471450329, 0.043829500675201416, 0.07086952775716782, 0.00798147451132536, 0.03823535144329071, 0.012795270420610905, -0.029460038989782333, -0.03888871893286705, 0.058275386691093445, 0.10422499477863312, -0.06010120362043381, -0.01204186212271452, 0.04128123074769974, 0.041004396975040436, -0.019192421808838844, 0.08789601922035217, -0.05611664429306984, -0.05725126340985298, 0.0352478101849556, 0.06790483742952347, -0.023958224803209305, 0.004501625429838896, -0.05567541718482971, -0.01363912783563137, -0.03029623068869114, -0.0030792749021202326, 0.0337614081799984, 0.04674616828560829, 0.053992580622434616, -0.043106354773044586, -0.016294000670313835, -0.03731372579932213, -0.04210026562213898, 0.04689417779445648, -0.047516901046037674, -0.00438032066449523, -0.03739508241415024, 0.08154267817735672, -0.005824218969792128, 0.015834808349609375, 0.004453557077795267, 0.09022702276706696, 0.05230655521154404, -0.09514907747507095, -0.05832017958164215, 0.06123165413737297, -0.039120081812143326, -0.08419584482908249, -0.019905515015125275, 0.07544422149658203, 0.04647131264209747, -0.003377879736945033, 0.01858760043978691, 0.04336598142981529, 0.05778539925813675, 0.024893654510378838, -0.052749402821063995, 0.03680329769849777, 0.08504659682512283, 0.027748461812734604, 0.04713822156190872, -0.000883170054294169 ]
varying\tamounts\tand\ttypes\tof\tcarbohydrate\tsources\tand\tblends\tis\tone\tstrategy\tfor\teliminating\npotential\tGI\tissues.\nAssessment\ttools\tused\tto\trule\tout\tfood-related\tissues\tinclude\t(1)\ta\tthorough\tdietary\tanalysis\nincluding\tan\tanalysis\tof\tfoods,\tfluids,\talcohol\tuse,\tand\tsupplements\tconsumed\tbefore,\tduring,\tand
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to\tlower\tlevels\tof\tinflammatory\tcytokines\tand\tincrease\tfecal\tmicrobial\tdiversity.\tThis\tsuggests\tthat\nexercise\tcan\tplay\n\ta\tprotective\tand\tpositive\trole\tin\tnourishing\tthe\tmicrobiota\twhen\tathletes\tare\nnutritionally\twell\tfed\tand\ttraining\tincorporates\tadequate\trecovery\t(\nO’Sullivan\tet\tal,\t2015\n).\tThis
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O’Sullivan\tet\tal,\t2015\n).\tThis\nsupports\ta\tbody\tof\tresearch\tthat\tsuggests\tthat\tthe\tGI\tsystem\tis\thighly\tadaptable.\tThe\trate\tof\ngastric\temptying\tand\tperceptions\tof\tfullness\tcan\tbe\tdecreased\tor\t“trained,”\tand\tthe\tdiet\tcan\tplay\nan\timportant\trole\t(\nJeukendrup,\t2017a\n).
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an\timportant\trole\t(\nJeukendrup,\t2017a\n).\nNutritional\tstrategies\tfor\tovercoming\tGI\tissues\tinclude\tan\telimination\tdiet\tor\tlow\tFODMAP\tdiet,\nand/or\ta\tcompetition-day\tdiet\tthat\tis\tindividualized\tto\tthe\tathlete\tbased\ton\ttheir\ttolerance\tof\nfoods.\tAnother\tstrategy\tis\tto\toffer\ta\thigh-carbohydrate\tdiet,\tas\tthis\tcan\tincrease\tthe\tactivity\tof
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glucose-1\ttransporters\t(SGLT1)\tin\tthe\tintestine\tallowing\tgreater\tcarbohydrate\tuptake\tand\noxidation\tduring\n\texercise\t(\nJeukendrup,\t2017b\n;\t\nKoon\tet\tal,\t2017\n).\nErgogenic\tAIDS\nAthletes\tare\talways\tlooking\tfor\tan\tedge,\tsuch\tas\ta\tnew\ttechnique,\ta\ttraining\tregimen,\tor\tgear\tthat
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might\thelp\tthem\timprove\tathletic\tperformance,\tincrease\tstrength\tand\tspeed,\tor\thasten\trecovery\nafter\ttraining.\tMany\tathletes\ttest\tthe\tlatest\ttrendy\tdiet\tor\tsupplement\tto\tachieve\tsports\tsuccess\tin\nspite\tof\twhether\tit\tsupports\toptimal\n\thealth\tor,\tat\tworst,\tleads\tto\tthe\trisk\tof\tillness,\tinjury,\tor\ta\tfailing
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drug\tdoping\tblood\ttest.\tUnfortunately,\tmany\tathletes\tare\tmisinformed\tabout\tthe\tbest\tway\tto\tachieve\nsports\tperformance\twith\tdiet\talone\t(\nKanter,\t2018\n).\nErgogenic\taids\n\tinclude\tany\ttraining\ttechnique,\tmechanical\tdevice,\tnutrition\tpractice,\npharmacologic\tmethod,\tor\tphysiologic\ttechnique\tthat\tcan\timprove\texercise\tperformance\tcapacity
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and\ttraining\tadaptations.\tMany\tathletes\tdevote\tsubstantial\ttime\tand\tenergy\tstriving\tfor\toptimal\nperformance\tand\ttraining\tand\tturn\tto\tergogenic\taids,\tespecially\tdietary\tsupplements\t(\nLarson-Meyer\net\tal,\t2018\n).\nThe\tFood\tand\tDrug\tAdministration\t(FDA)\tregulates\tdietary\tsupplement\tproducts\tand\tingredients\tin
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addition\tto\tlabeling,\tproduct\tclaims,\tpackage\tinserts,\tand\taccompanying\tliterature.\tThe\tFederal\nTrade\tCommission\t(FTC)\tregulates\tdietary\tsupplement\tadvertising.\t(See\t\nChapter\t11\n\tfor\ta\tdefinition\nof\ta\tdietary\tsupplement\tas\tdefined\tby\tthe\tDietary\tSupplement\tHealth\tand\tEducation\tAct\t[DSHEA]\tof\n1994.)
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1994.)\nAccording\tto\tthe\tlaw,\tdietary\tsupplement\tmanufacturers\tare\tallowed\tto\tpublish\tinformation\tabout\nthe\tbenefits\tof\tdietary\tsupplements\tin\tthe\tform\tof\tadvertisements,\tincluding\tstructure\tand\tfunction\nclaims.\tThis\tresults\tin\ta\tgreat\tdeal\tof\tprinted\tmaterial\tthat\tcan\tbe\tconfusing\tto\tathletes\tat\tthe\tpoint
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of\tsale\tof\tnutritional\tproducts.\tIn\taddition,\tathletes\tare\tbombarded\twith\tadvertisements\tand\ntestimonials\tfrom\tother\tathletes\tand\tcoaches\tabout\tthe\teffects\tof\tdietary\tsupplements\ton\nperformance.\nThe\tuse\tof\tergogenic\taids\tin\tthe\tform\tof\tdietary\tsupplements\tis\twidespread\tin\tall\tsports\t(\nGarthe\nand\tMaughan,\t2018
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Garthe\nand\tMaughan,\t2018\n).\tMany\tathletes,\twhether\trecreational\tor\tprofessional,\tuse\tsome\tform\tof\tdietary\nsupplementation\tto\timprove\tathletic\tperformance\tor\tto\tassist\twith\tweight\tloss\t(\nKnapik\tet\tal,\t2016\n;\nLarson-Meyer\tet\tal,\t2018\n).\nAccording\tto\tone\tsurvey,\t88%\tof\tcollegiate\tathletes\treport\tusing\tone\tor\tmore\tnutritional
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supplements\t(\nBuell\tet\tal,\t2013\n).\tA\trecent\tmeta-analysis\tof\t159\tstudies\tsuggested\tthat\tit\tis\tdifficult\n\tto\ngeneralize\tabout\tdietary\tsupplement\tuse\tby\tathletes\tbecause\tof\tthe\tlack\tof\thomogeneity\tamong\nstudies\t(\nKnapik\tet\tal,\t2016\n).\tData\thas\tsuggested\tthat\telite\tathletes\tuse\tdietary\tsupplements\tmore
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than\tnonelite\tathletes,\tuse\tis\tsimilar\tfor\tmen\tand\twomen,\tand\tappears\tto\tchange\tlittle\tover\ttime.\nAdditionally,\ta\tlarger\tproportion\tof\tathletes\tuse\tdietary\tsupplements\tcompared\twith\tthe\tgeneral\tU.S.\npopulation.\nSurveys\tshow\treasons\tfor\tsupplement\tuse\tare\tvaried\tand\tdiffer\tbetween\tgenders.\tWomen\tathletes
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often\ttake\tsupplements\tfor\ttheir\thealth,\tor\tto\tovercome\tan\tinadequate\tdiet,\twhereas\tmen\tmay\ttake\nsupplements\tto\timprove\tspeed,\tagility,\tstrength,\tand\tpower,\tand\talso\tuse\tthem\tto\thelp\tbuild\tbody\nmass\tand\treduce\tweight\tor\texcess\tbody\tfat.\tIn\tone\tstudy,\t75%\tof\tadolescent\tathletes\treported\ttaking\nsupplements,
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supplements,\n\tmales\tfor\tsports\tperformance\tenhancement\tand\tbetter\tmuscle\tdevelopment\tand\nfunction,\twhereas\tfemales\treported\ttaking\tsupplements\tfor\timmune\tsystem\timprovement\t(\nZdešar\nKotnik\tet\tal,\t2017\n).\tSee\t\nTable\t22.5\n\tfor\tdiscussion\tof\tergogenic\taids\tcommonly\tused\tby\tathletes.\nTABLE\t22.5
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TABLE\t22.5\nCommonly\tUsed\tBanned\tand\tRecreational\tDrugs\tUsed\tby\tAthletes\nErgogenic\tDrug\nGoals\tof\tUse\nAthletic\tEffect\nAdverse\tEffects\nAlcohol\nReduce\tstress\tand\ninhibition;\tmost\nwidespread\nused\tdrug\tin\nsport\t(88%\tof\nintercollegiate\nathletes)\nNo\tbenefits\nDependence\tproducing;\ttwofold\thigher\nrisk\tof\tinjury;\tcardiovascular/liver
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risk\tof\tinjury;\tcardiovascular/liver\ndisease;\tworsens\tleft\tventricular\ndysfunction;\tdecreases\tamino\tacid,\nglucose\tutilization;\tdecreases\nenergy,\thypoglycemia;\tdehydration;\ndecreases\tskeletal\tmuscle\tcapillary\ndensity,\tcross-sectional\tarea;\ninhibits\tsarcolemmal\tcalcium\nchannel\tactions,\timpairs\texcitation-\ncontraction\tcoupling\tand\tdiminishes
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contraction\tcoupling\tand\tdiminishes\nperformance;\tdecreases\tmuscle\noxidative\tcapability;\tcompromises\nblood\ncoagulation/fibrinolysis/postexercise\nperturbations\tin\tclotting\tfactors;\npositive\tenergy\tbalance,\tobesity;\nincreases\tHR\tand\tVO\n2\n,\treductions\tin\npower\toutput\nNicotine\nCNS\npsychostimulant\nMixed:\tEnhances\nbrain\nnorepinephrine\nand\tdopamine;
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psychostimulant\nMixed:\tEnhances\nbrain\nnorepinephrine\nand\tdopamine;\nhigher\tdoses\nenhance\nserotonin\tand\nopiate\texerting\ncalming\tand\ndepressing\neffect,\nincreases\tpain\ntolerance;\nincreases\nmuscle\tblood\nflow,\tlipolysis;\nmay\timprove\ncognitive\nfunction,\nlearning\nmemory,\tand\nreaction\ttime\nand\tfine\tmotor\nabilities;\tdelays\ncentral\tfatigue
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reaction\ttime\nand\tfine\tmotor\nabilities;\tdelays\ncentral\tfatigue\nAddictive;\tmay\tlead\tto\tdevelopment\tof\nrespiratory,\tcardio,\n\tand\tskin\ndiseases\tand\ttobacco-related\ncancers\tif\tsmoked;\tincreases\theart\nrate\tand\tblood\tpressure,\tcardiac\nstroke\tvolume\tand\toutput,\tand\ncoronary\tblood\tflow;\tincreases\tskin\ntemperature\nTetrahydrocannabinol\n(marijuana,\tcannabis)
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temperature\nTetrahydrocannabinol\n(marijuana,\tcannabis)\nDiminish\nnerves/pre\ncompetition\nstress,\tand\nanxiety;\nrelax/decrease\ninhibition;\nimprove\tsleep\nNo\tpositive\teffect\nIncreases\tHR\tand\tBP\tat\trest;\tphysical\nwork\tcapacity\tdecreases\n\tby\t25%;\ndecrease\tin\tstanding\tsteadiness,\nreaction\ttime,\tpsychomotor\nperformance\nAnabolic\tandrogenic\nsteroids
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