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Gastroesophageal\tReflux\t(GER)\tand\nGastroesophageal\tReflux\tDisease\t(GERD)\tin\tAdults\n\t(website):\t\nhttp://digestive.niddk.nih.gov/;\n\tSong\tet\tal,\n2013.
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BOX\t26.4\nIntegrative\tApproaches\tto\tGI\tConditions,\tIncluding\tAcid\nReflux/Heartburn\nAccording\tto\n\tthe\tNational\tHealth\tInterview\tSurvey\t(NHIS),\twhich\tis\tpublished\tevery\t5\tyears,\ncomplementary\tand\tintegrative\tmedicine\t(CIM)\tuse\tis\tmore\tprevalent\tin\tthose\twith
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gastrointestinal\t(GI)\tconditions\tversus\tthose\twithout.\tA\tfollow-up\tstudy\tto\tthe\tmost\trecent\treport\nfound\tthat\t42%\tof\trespondents\twith\tGI\tconditions\tsaw\ta\tpractitioner\tfor\tor\tused\tCIM\twithin\tthe\nprevious\tyear,\twhile\tonly\t28%\tof\tthose\twithout\n\tGI\tconditions\tused\tCIM.\tOf\tthose\twho\treported
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GI\tconditions\tused\tCIM.\tOf\tthose\twho\treported\nhaving\tGI\tconditions,\t3%\tused\tat\tleast\tone\tCIM\tmodality\tto\taddress\tthe\tproblem.\tGI\tconditions,\tas\ndefined\tby\tthe\tNHIS,\twere\tlimited\tto\tone\tor\tmore\tof\tthe\tfollowing:\tabdominal\tpain,\tnausea\tand/or\nvomiting,\tliver\tconditions,\tdigestive\tallergies,\tstomach\tor\tintestinal\tillness,\tand\tacid
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reflux/heartburn.\tThe\tmost\tcommon\tCIM\tmodalities\tused\twere\tpaired\tinto\n\tgroups\tas\tfollows\n(\nDossett\tet\tal,\t2014\n):\n•\t\nHerbs\tand\tnonvitamin\tnonmineral\tsupplements,\tincluding\tzinc,\tglutamine,\ndeglycyrrhizinated\tlicorice,\tand\taloe\tgel\n•\t\nManipulative\ttherapies:\tchiropractic,\tosteopathic,\tmassage,\tcraniosacral\ttherapy\n•
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•\t\nMind-body\ttherapies:\thypnosis,\tbiofeedback,\tmeditation,\timagery,\tprogressive\trelaxation\n•\t\nMind-body\texercise:\tyoga,\ttai\tchi,\tqi\tgong\n•\t\nSpecial\tdiets:\n\tvegetarian\tor\tvegan,\tmacrobiotic,\tAtkins,\tPritikin,\tOrnish,\tor\tdietary\ncounseling\n•\t\nMovement\ttherapy:\tFeldenkrais,\tAlexander\ttechnique,\tPilates,\tTrager\tpsychological\nintegration\n•
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integration\n•\t\nOther:\tacupuncture,\tAyurveda,\tchelation,\tenergy\thealing,\thomeopathy,\tnaturopathy,\ntraditional\thealers\nAmong\tthese,\therbs\tand\tsupplements,\tmind-body\ttherapies,\tand\tmanipulative\ttherapies\twere\nthe\ttop\tthree\trespondents\n\treported\tusing\tto\taddress\ta\tGI\tcondition,\tand\t47%\tused\t3\tor\tmore
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reported\tusing\tto\taddress\ta\tGI\tcondition,\tand\t47%\tused\t3\tor\tmore\nmodalities.\tOverwhelmingly,\t80%\treported\tthat\tthey\tperceived\tCIM\ttherapy\tto\tbe\thelpful,\tbut\tonly\n70%\tinformed\ttheir\tmedical\tprovider\tabout\tusing\tCIM.\tWhile\tthe\tNHIS\tacknowledges\tsome\nimportant\tdetails\tabout\tthe\tuse\tof\tCIM\tand\tGI\tconditions,\tthe\tdata\tare\tself-reported,\tand\tthe
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conditions\twere\tlimited\tto\tthose\tincluded\tin\tthe\tsurvey.\n\tThe\tfollow-up\tstudy\tis\timportant\tbecause\nit\treveals\ta\tsignificant\tnumber\tof\tindividuals\twho\tare\tintegrating\tCIM\tmodalities\twith\ttraditional\ntreatment\tfor\tGI\tdisorders\t(\nDossett\tet\tal,\t2014\n).\nWith\tmany\tpatients\tusing\tintegrative\tmedicine\tto\ttreat\tupper\tGI\tconditions,\tincluding\tacid
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support\ttheir\tuse.\tWhile\tacupuncture,\tweight\tloss,\tand\televating\tthe\thead\tof\tthe\tbed\thave\tgood\nevidence,\tthere\tis\talso\treasonable\tevidence\tto\tsupport\tmind-body\tmodalities\tand\tdietary\nmodifications\t(\nDossett\tet\tal,\t2017\n;\t\nEherer\tet\tal,\t2012\n;\t\nJarosz\tand\tTaraszewska,\t2014\n,\t\nMaradey-\nRomero\tet\tal,\t2014
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;\t\nJarosz\tand\tTaraszewska,\t2014\n,\t\nMaradey-\nRomero\tet\tal,\t2014\n).\tFurther\tstudy\tis\tneeded,\tand\tspecific\trecommendations\tshould\tbe\ttailored\tto\nthe\tindividual\tby\ta\twell-trained\tprofessional\tusing\tevidence-based\tdata\tfrom\treliable\tsources,\tas\nmany\tpatients\tmay\tlook\tto\tanecdotal\tevidence\tthat\tis\tnot\tfounded\tin\tscientific\tresearch\t(\nCowan,\n2014\n).
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Cowan,\n2014\n).\nSurgery\tof\tthe\tesophagus\nThe\tprimary\tindication\n\tfor\tan\t\nesophagectomy\n\tis\tesophageal\tcancer\tor\tBE\twith\thigh-grade\ndysplasia.\tA\tpatient\tundergoing\tesophagectomy\toften\tpresents\twith\tdysphagia,\tdecreased\tappetite,\nside\teffects\tfrom\tchemotherapy,\tand\tweight\tloss.\tEsophagectomy\trequires\tthat\tthere\tbe\tanother
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conduit\tin\tplace\tto\ttransport\tfood\tfrom\tthe\toropharynx\tto\tthe\trest\tof\tthe\tGI\ttract\tfor\tdigestion\tand\nabsorption.\tPlacement\tof\tan\tenteral\tfeeding\n\ttube\tpreoperatively,\tor\tat\tthe\ttime\tof\tsurgery,\tprovides\nenteral\taccess\tfor\tpatients\twho\twill\texperience\teating\tchallenges\tand\ta\tslow\ttransition\tback\tto\ta
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normal\tdiet.\tThe\tenteral\troute\tof\tnutrition\tis\tpreferred;\thowever,\tif\tthe\tGI\ttract\tis\tnot\tfunctional,\nparenteral\tnutrition\t(PN)\tmust\tbe\tprovided\t(see\t\nChapter\t12\n).\nMedical\tnutrition\ttherapy\nNutrition\tassessment\tof\tan\tesophagectomy\tcandidate\n\tincludes\tevaluation\tof\ttreatment\tplans,\thistory
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includes\tevaluation\tof\ttreatment\tplans,\thistory\nof\tweight\tloss,\tand\tthe\tability\tto\tswallow\tsolid\tfoods\tand\tliquids.\tGenerally,\tthe\tonly\tesophagectomy\npatients\tscreened\tat\tlow\tnutrition\trisk\tpreoperatively\tare\tthose\twith\tBE\twith\thigh-grade\tdysplasia,\nor\tthose\twho\tare\tasymptomatic.\nPreoperative\tphase.\nSwallowing\tdifficulty\t(\ndysphagia
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Preoperative\tphase.\nSwallowing\tdifficulty\t(\ndysphagia\n)\tis\tthe\tcommonly\tidentified\tproblem\tin\tpatients\tawaiting\tan\nesophagectomy.\tDietary\tmodifications\tmay\trange\tfrom\tregular\tfood\twith\tadequate\tchewing\tand\tslow\neating\tto\tsoft\tfoods\tor\tto\tpureed\tor\tblenderized\tfoods.\tPatients\tmay\talso\tbenefit\tfrom\tthe\taddition\tof
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Postoperative\tphase.\nA\t\ngastric\tpull-up\n\tprocedure\t(\nFig.\t26.4\n)\tinvolves\tremoval\tof\ta\tsegment\tof\tor\tthe\tentire\tesophageal\ntract\tand\treplacing\tit\twith\tthe\tstomach\ttissue.\tComplications\tafter\tthis\tprocedure\tinclude\tincreased\nrisk\tof\taspiration,\tdysphagia,\tanastomosis\tleak,\n\twound\tinfection,\tand\tstricture\tat\tthe\tanastomosis
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wound\tinfection,\tand\tstricture\tat\tthe\tanastomosis\nsite.\tA\tjejunostomy\tfeeding\ttube\tmay\tbe\tplaced\tat\tsurgery\tto\tprovide\tpostoperative\tnutrition\tuntil\nadequate\toral\tintake\tis\tachieved.\tThe\ttube\tfeeding\tschedule\tis\tchanged\teventually\tfrom\tcontinuous\nto\tcyclical\tfeedings\tat\tnight\tas\tthe\tpatient\tis\ttransitioned\tto\tan\toral\tdiet\tduring\tthe\tday.
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FIG.\t26.4\nGastric\tpull-up.\n\t\nSource:\n\t(Cleveland\tClinic,\tCleveland,\tOhio.)\nTransition\tto\toral\tintake\tpostoperatively\tproceeds\tfrom\tclear\tliquids\tto\ta\tsoft,\tmoist\tfoods\tdiet.\tThe\npatient\tis\tadvised\tto\teat\tsmall\tfrequent\tmeals\twith\tlimited\tfluids\tat\tmealtimes.\tSome\tpatients\tmay
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experience\tdumping\tsyndrome\tif\tfood\tpasses\tinto\tthe\tsmall\tintestine\ttoo\tquickly.\tThe\tsymptoms\tof\ndumping\tsyndrome\tinclude\n\tabdominal\tpain,\tnausea,\tdiarrhea,\tweakness,\tand\tdizziness.\t\nBox\t26.5\n\tlists\ndietary\tguidelines\tafter\tesophageal\tsurgery\tto\tprevent\tdumping\tsyndrome\t(see\t\nDumping\tSyndrome\nlater\tin\tthis\tchapter\tfor\tmore\tdetails).\nBOX\t26.5
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Dumping\tSyndrome\nlater\tin\tthis\tchapter\tfor\tmore\tdetails).\nBOX\t26.5\nNutrition\tGuidelines\tAfter\tEsophagectomy\n1.\t\nEnteral\tnutrition\tis\tprovided\tthrough\ta\tjejunostomy\tfeeding\ttube\tafter\tesophagectomy.\n2.\t\nA\tpatient\tcannot\teat\tor\tdrink\tanything\n\tby\tmouth\tuntil\tinstructed\tby\tthe\tdoctor.\n3.
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by\tmouth\tuntil\tinstructed\tby\tthe\tdoctor.\n3.\t\nOnce\tan\toral\tdiet\tis\tallowed,\tpatient\tis\tprovided\twith\tspecific\tguidelines\ton\thow\tto\ttaper\nthe\ttube\tfeedings\tand\tadvance\tthe\toral\tdiet\t(from\tsips\tof\tclear\tliquids\tto\tvery\tmoist,\ttender\nfoods).\n4.\t\nIt\tmay\ttake\tseveral\tweeks\tto\ttaper\tthe\ttube\tfeedings\tand\tadjust\tto\toral\tdiet.\tWhen\ttube
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feeding\tis\tdiscontinued,\tthe\tpatient\tshould\tcontinue\tto\tflush\tthe\n\tjejunostomy\ttube\tdaily.\tA\npatient\twill\tcontinue\tto\tadjust\tto\toral\tfeedings\tfor\tabout\t3\tmonths.\n5.\t\nDuring\tthe\t3-month\ttransition:\n•\t\nEat\tsix\tsmall\tmeals\tper\tday\tand\tinclude\tsources\tof\tprotein\tand\tfat\tat\tevery\tsmall\nmeal.\n•
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meal.\n•\t\nChoose\tvery\ttender,\tmoist\tfoods\tthat\tcan\tbe\teasily\tcut\twith\tthe\tside\tof\tfork\tor\tspoon\nand\tuse\tsauces\tor\tgravies\tto\tmoisten\tfood.\n•\t\nGradually\tincrease\tthe\tvolume\tand\tvariety\n\tof\tfoods\tat\teach\tmeal.\n•\t\nAvoid\tskins,\tseeds,\tnuts,\ttough\tor\tdry\tmeats,\tbreads\tand\trolls,\tpeanut\tbutter,\tfried
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0.052592530846595764, 0.03750630095601082, 0.06424761563539505, 0.13223907351493835, -4.8557041054664296e-8, 0.024190066382288933, -0.0641382560133934, -0.017126888036727905, 0.06264333426952362, 0.0806787982583046, -0.0662245899438858, 0.10096674412488937, -0.01204961258918047, -0.016522105783224106, -0.024780333042144775, 0.03358190506696701, 0.08805719017982483, -0.06067385897040367, -0.027654489502310753, 0.062176287174224854, 0.007424413692206144, 0.03136252984404564, 0.04378664493560791, -0.0013324841856956482, -0.025305282324552536, 0.029713120311498642, 0.08665566891431808, -0.03295597806572914, -0.03745841979980469, -0.043830517679452896, 0.013686669059097767, -0.07066391408443451, 0.0017319516045972705, 0.049990128725767136, 0.05267069861292839, 0.056878574192523956, -0.04945653676986694, -0.057134438306093216, -0.04729587212204933, -0.02191101387143135, 0.049345459789037704, -0.13145364820957184, -0.03496040031313896, 0.005671619437634945, 0.09581337124109268, -0.005533640738576651, -0.00906367041170597, -0.0024555751588195562, 0.053392767906188965, -0.006953379139304161, -0.023789821192622185, -0.05772769823670387, 0.07471293210983276, 0.009759361855685711, -0.07150011509656906, -0.054720617830753326, 0.11803118884563446, 0.032030344009399414, -0.027906008064746857, 0.010081040672957897, -0.0072852931916713715, 0.08166065067052841, 0.015961403027176857, -0.005981015972793102, 0.003224103944376111, 0.04820554703474045, 0.06743455678224564, 0.0385504849255085, -0.020878100767731667 ]
and\tgreasy\tfoods,\traw\tvegetables,\tcooked\tcorn\tand\tpeas,\tand\traw\tfruits.\n•\t\nAvoid\titems\tthat\tcan\tcause\theartburn\tand\tstomach\treflux\tsuch\tas\tcaffeine,\tcitrus\nfruits,\tpineapples,\ttomatoes,\tcarbonated\tbeverages,\tmints,\tand\talcohol.\n•\t\nDrink\tno\tmore\tthan\t4\tfluid\tounces\tof\twater\tor\tother\tliquids\n\twith\tmeals.\tDrink\tfluids
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0.06041489914059639, 0.0869603306055069, 0.14081226289272308, -4.258847141613842e-8, 0.003910196013748646, -0.04289491847157478, -0.010861444287002087, 0.05093034729361534, 0.054357364773750305, -0.03190139681100845, 0.04154236614704132, 0.05863484367728233, -0.030056407675147057, -0.07602404057979584, 0.003801973769441247, 0.09157177060842514, -0.07268918305635452, -0.0024301656521856785, 0.07871363312005997, 0.016694003716111183, -0.001144125359132886, 0.05776698887348175, -0.022159909829497337, -0.06502354890108109, -0.035838376730680466, 0.07060983777046204, -0.008195162750780582, -0.0013282637810334563, -0.049767620861530304, -0.0323430560529232, -0.05494849756360054, -0.006246213335543871, 0.05217882618308067, 0.031036071479320526, 0.030861947685480118, -0.03709349036216736, -0.038037825375795364, -0.008365493267774582, 0.016241487115621567, 0.030101997777819633, -0.08192632347345352, -0.03793420270085335, -0.044134754687547684, 0.08868829905986786, -0.07999162375926971, 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with\tmeals.\tDrink\tfluids\nabout\t30\tminutes\tbefore\tor\tafter\tthe\tmeal\tand\tsip\tslowly.\n•\t\nAvoid\tconcentrated\tsweets\tand\tsugars.\n•\t\nEat\tslowly\tand\tchew\tfoods\tthoroughly.\n6.\t\nAfter\t3\tmonths,\tmore\tfood\tshould\tbe\tadded\tback\tinto\tthe\tdiet.\tTry\tone\tnew\tfood\tor\nbeverage\tat\ta\ttime.\n7.
[ -0.03137781843543053, -0.03153024986386299, 0.025499382987618446, -0.03864189609885216, -0.06582392752170563, 0.00531030585989356, 0.10275156050920486, -0.01214595977216959, 0.002405818086117506, 0.0412912555038929, 0.10181897133588791, -0.04733941704034805, 0.0445418544113636, -0.017244955524802208, 0.008647934533655643, -0.008297644555568695, -0.002962190192192793, 0.020212214440107346, -0.04633346572518349, -0.0843357965350151, 0.052940405905246735, 0.07420895248651505, 0.058493439108133316, 0.004513212013989687, 0.03854973241686821, 0.035151515156030655, -0.04849005863070488, -0.018942195922136307, 0.023433273658156395, -0.0685662180185318, -0.08582525700330734, 0.043963365256786346, -0.021380897611379623, -0.03142404928803444, 0.0010225846199318767, 0.009760862216353416, -0.03298642113804817, 0.004042241722345352, 0.09171965718269348, 0.02820543572306633, 0.002398950979113579, -0.10946980118751526, -0.05797217786312103, 0.004854040220379829, -0.015661342069506645, 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0.009865596890449524, 0.0022035473957657814, -0.04675072431564331, 0.06237686797976494, 0.026497798040509224, -0.07599643617868423, -0.04172564297914505, 0.0574454627931118, -0.021574851125478745, -0.027152815833687782, -0.0014680256135761738, 0.092957504093647, 0.03373685106635094, -0.016305072233080864, -0.002486417070031166, 0.0072899432852864265, 0.04087691754102707, -0.0014149013441056013, -0.020685937255620956, 0.03147172927856445, 0.05086948722600937, 0.017018234357237816, 0.034660059958696365, -0.03466913849115372 ]
beverage\tat\ta\ttime.\n7.\t\nAfter\t6\tmonths,\ta\tpatient\tshould\tbe\teating\tnormally.\tIt\tis\tstill\tadvised\tto\teat\tfrequent\tsmall\nmeals.
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Head\n\tand\tneck\tcancer\nPathophysiology\nCancers\tof\tthe\tupper\taerodigestive\ttract,\tcollectively\treferred\tto\tas\thead\tand\tneck\tcancers,\tcomprise\nmalignancies\tof\tthe\toral\tcavity\t(lips\tand\tinside\tof\tthe\tmouth,\tincluding\tthe\tfront\tportion\tof\tthe\ntongue\tand\tthe\troof\tand\tfloor\tof\tthe\tmouth),\tthe\toropharynx\t(back\tportion\tof\tthe\ttongue\tand\tthe\tpart
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digestive\ttract\tfunction,\tand\toral\tintake\tis\toften\tinsufficient\tduring\tand\tafter\ttherapy.\tApproximately\n35%\tto\t60%\tof\tall\tpatients\twith\thead\tand\tneck\tcancer\tare\tmalnourished\n\tat\tthe\ttime\tof\tdiagnosis\tdue\nto\tintake\tdifficulties,\ttumor\tburden,\tand\tcachexia\t(\nAlshadwi\tand\tNadershah,\t2013\n).\tDysphagia\tis\ta
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Alshadwi\tand\tNadershah,\t2013\n).\tDysphagia\tis\ta\nhallmark\tof\thead\tand\tneck\tcancer;\tit\toccurs\tas\ta\tresult\tof\tmechanical\tobstruction,\tsensory\nimpairment,\tor\t\nodynophagia\n\t(painful\tswallowing).\tIn\tthese\tpatients\tthere\tis\ta\thigh\tprevalence\tof\nalcohol\tabuse\tand\tlong-term\ttobacco\tuse,\twhich\tare\talso\tassociated\twith\tchronic\tmalnutrition\n(
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(\nSchoeff\tet\tal,\t2013\n).\nMedical\tnutrition\ttherapy\nDepending\ton\tthe\ttumor\tsite,\tthe\tsurgical\tprocedure\tmay\tsignificantly\talter\tthe\tanatomy\tand\tlead\tto\nscarring\tthat\tcan\tnegatively\taffect\tswallowing.\tThe\tpatient\tis\tlikely\tto\tbe\trestricted\tfrom\toral\tintake\nwhile\thealing\tfrom\tthe\tsurgery.\tPlacement\tof\ta\tgastrostomy\ttube\tis\tthe\tmost\tcommon\tapproach\tto
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ensure\tsafe\tdelivery\tof\tadequate\tnutrition,\n\tbut\tthe\toptimal\ttiming\tis\tnot\tdefined.\tMany\tclinicians\tmay\nplace\tthem\tprophylactically\tbefore\tthe\tstart\tof\tradiation\tor\tsurgical\tresection\tto\tprevent\ncomplications\tfrom\tmalnutrition\t(\nMarian\tet\tal,\t2017\n).\tAlthough\tthe\tgoal\tis\teventual\ttransition\tto\toral
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).\tAlthough\tthe\tgoal\tis\teventual\ttransition\tto\toral\nfeeding,\tsome\tpatients\twill\trequire\tadditional\tenteral\tnutrition\t(EN)\tbecause\tof\tstructural\tand\nsensory\tdeficits.\nAggressive\tprophylactic\tswallowing\n\ttherapy\tis\ta\trecent\tdevelopment\tin\tthe\ttreatment\tof\tdysphagia
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therapy\tis\ta\trecent\tdevelopment\tin\tthe\ttreatment\tof\tdysphagia\nin\tpatients\twith\thead\tand\tneck\tcancer.\tThis\tapproach\tfocuses\ton\tmaintaining\tor\tregaining\tfunction\nrather\tthan\tsimply\taccommodating\tdysfunction\t(reliance\ton\tfeeding\ttube)\tand\tempowers\tpatients\tto\nprogress\tcarefully\twith\toral\tintake\tdespite\timperfect\tswallowing\t(\nSchoeff\tet\tal,\t2013\n).
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Schoeff\tet\tal,\t2013\n).\nThe\tstomach\nThe\tstomach\taccommodates\tand\tstores\n\tmeals,\tmixes\tfood\twith\tgastric\tsecretions,\tand\tcontrols\nemptying\tinto\tthe\tduodenum.\tGastric\tvolume\tis\tapproximately\t50\tmL\twhen\tempty\tbut\tcan\texpand\tto\napproximately\t4\tL.\tGastric\t\nparietal\tcells\n\t(acid-producing\tcells)\tproduce\t1.5\tto\t2\tL\tof\tacid\tdaily,
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(acid-producing\tcells)\tproduce\t1.5\tto\t2\tL\tof\tacid\tdaily,\nresulting\tin\ta\tpH\tbetween\t1\tand\t2\t(see\t\nChapter\t1\n\tfor\ta\tdetailed\tdiscussion\tof\tnormal\tstomach\nfunction).\nThe\tmucosa\tof\tthe\tstomach\tand\tduodenum\tis\n\tprotected\tfrom\tproteolytic\tactions\tof\tgastric\tacid\tand
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affects\tan\testimated\t20%\tto\t40%\tof\tthe\tgeneral\tpopulation\tand\tsignificantly\treduces\tquality\tof\tlife\n(\nFord\tand\tMoayyedi,\t2013\n).\tThe\tunderlying\tcauses\tof\tdyspepsia\n\tmay\tinclude\tGERD,\tpeptic\tulcer\ndisease,\tgastritis,\tgallbladder\tdisease,\tor\tother\tidentifiable\tpathologic\tconditions.
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Functional\tgastrointestinal\tdisorders\t(FGIDs),\tnow\tknown\tas\tdisorders\tof\tgut-brain\tinteraction\n(DGBI),\thave\tbeen\tdiagnosed\tand\tclassified\tusing\tstandards\tdefined\tby\tthe\tRome\tcriteria\tsince\tits\ninception\tin\tthe\tlate\t1980s.\tThe\tmost\trecent\tupdate\tusing\tcurrent\tscientific\tdata\twas\n\treleased\tin\nMay\t2016\tand\tis\tknown\tas\tthe\t\nRome\tIV\tcriteria
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released\tin\nMay\t2016\tand\tis\tknown\tas\tthe\t\nRome\tIV\tcriteria\n.\tAccording\tto\tthese\tcriteria,\t\nfunctional\tdyspepsia\n(FD)\tis\tdefined\tas\tan\tumbrella\tterm\tto\tinclude\tpatients\twith\tpostprandial\tdistress\tsyndrome\t(PDS)\nand\tepigastric\tpain\tsyndrome\t(EPS)\t(\nSchmulson\tand\tDrossman,\t2017\n).\tSymptoms\tcan\tinclude
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Schmulson\tand\tDrossman,\t2017\n).\tSymptoms\tcan\tinclude\npostprandial\tfullness\tand\tearly\tsatiety,\tbut\talso\tmay\tcause\tpatients\tto\tperceive\tepigastric\tdiscomfort\nand/or\tburning\tafter\tmeals.\tThe\tsyndromes\tcan\toverlap\tand\tare\tconsidered\tgastroduodenal\ndisorders\tthat\toccur\tin\tthe\tabsence\tof\tany\torganic,\tsystemic,\tor\tmetabolic\tdisease\tlikely\tto\texplain
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the\tsymptoms\t(\nTalley\tand\tFord,\t2015\n).\tThe\tword\tdiscomfort\tis\timportant\tto\temphasize,\tas\tmany\npatients\twill\tnot\tcomplain\tof\tpain\tbut\trather\tof\tburning\tand\tpressure\tor\tfullness\tin\tthe\tepigastric\narea,\twith\ta\tfrequent\n\tcomplaint\tof\tearly\tsatiety.\tBelching,\tabdominal\tbloating,\tand\tnausea\tcan\talso
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be\tpresent\tin\tboth\tsyndromes,\tbut\tvomiting\tis\tconsidered\tan\tunusual\toccurrence\t(\nSchmulson\tand\nDrossman,\t2017\n).\nMedical\tnutrition\ttherapy\nCurrent\ttreatments\tfor\tFD\thave\tgenerally\tignored\tthe\tpotential\trole\tof\tdiet.\tThe\tpossible\teffect\tof\nspecific\tfoods\tand\tmacronutrients\tand\tother\tdietary\thabits\tto\tinduce\tor\texacerbate\n\tFD\tsymptoms\thas
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FD\tsymptoms\thas\nbeen\tpoorly\tstudied,\tand\toften\tthere\tare\tconflicting\tresults\t(\nLacy\tet\tal,\t2012\n).\tHowever,\tone\tmore\nrecent\tstudy\tdemonstrated\tspicy,\tpickled,\tand\thigh-fat\tfoods\tas\tcatalysts,\tinducing\tsymptoms\tthe\nmost\tin\tpatients\twith\tthis\tcondition\t(\nAkhondi-Meybodi\tet\tal,\t2015\n).\tUsing\ta\tfood\tand\tsymptom\tdiary
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Akhondi-Meybodi\tet\tal,\t2015\n).\tUsing\ta\tfood\tand\tsymptom\tdiary\nduring\ta\tclinical\tevaluation\tof\ta\tpatient\twith\tFD\tand\tassessing\tsymptoms\tassociated\twith\n\teating
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patterns\tis\tuseful.\tDietary\tmodifications\tsuch\tas\tconsuming\tsmaller\tmeals\twith\ta\treduction\tin\tdietary\nfat\tmay\tbe\tpromising\tin\tFD\ttherapy.\tHelping\tthe\tpatient\tidentify\tproblematic\tfoods\talso\tcan\tbe\nhelpful.\nGastritis\tand\tpeptic\tulcers\nPathophysiology\nGastritis\n\tis\ta\tnonspecific\tterm\tliterally\tmeaning\tinflammation\tof\tthe\tstomach.\tIt\tcan\tbe\tused\tto
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describe\tsymptoms\trelating\tto\tthe\tstomach,\n\tan\tendoscopic\tappearance\tof\tthe\tgastric\tmucosa,\tor\ta\nhistologic\tchange\tcharacterized\tby\tinfiltration\tof\tthe\tepithelium\twith\tinflammatory\tcells\tsuch\tas\npolymorphonuclear\tcells\t(PMNs).\tAcute\tgastritis\trefers\tto\trapid\tonset\tof\tinflammation\tand
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symptoms.\tChronic\tgastritis\tmay\toccur\tover\ta\tperiod\tof\tmonths\tto\tdecades,\twith\treoccurring\nsymptoms.\tSymptoms\tinclude\tnausea,\tvomiting,\tmalaise,\tanorexia,\n\themorrhage,\tand\tepigastric\tpain.\nProlonged\tgastritis\tmay\tresult\tin\tatrophy\tand\tloss\tof\tstomach\tparietal\tcells,\twith\ta\tloss\tof\tHCl
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secretion\t(achlorhydria)\tand\tintrinsic\tfactor,\tresulting\tin\tpernicious\tanemia\t(see\t\nChapter\t31\n).\nHelicobacter\tpylori\n\tgastritis\nHelicobacter\tpylori\n\tis\ta\tgram-negative\tbacteria\tthat\tis\tsomewhat\tresistant\tto\tthe\tacidic\nenvironment\tin\tthe\tstomach.\t\nH.\tpylori\n\tinfection\n\tis\tresponsible\tfor\tmost\tcases\tof\tchronic\tinflammation
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infection\n\tis\tresponsible\tfor\tmost\tcases\tof\tchronic\tinflammation\nof\tthe\tgastric\tmucosa\tand\tpeptic\tulcer,\tgastric\tcancer,\tand\t\natrophic\tgastritis\n\t(chronic\tinflammation\nwith\tdeterioration\tof\tthe\tmucous\tmembrane\tand\tglands),\tresulting\tin\tachlorhydria\tand\tloss\tof\nintrinsic\tfactor\t(\nDos\tSantos\tand\tCarvalho,\t2015\n).\nH.\tpylori
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intrinsic\tfactor\t(\nDos\tSantos\tand\tCarvalho,\t2015\n).\nH.\tpylori\n\tis\ta\tknown\tunderlying\tcause\tof\tnoncardia\tgastric\tcancer\tand\tresponsible\tfor\tdeaths\tfrom\npeptic\tulcer\t(\nAxon,\t2014\n).\tAn\tupdated\tclassification\tof\tgastric\tcancers\twas\tadopted\tin\tpart\tbecause\nof\tthe\trole\tof\t\nH.\tpylori,
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of\tthe\trole\tof\t\nH.\tpylori,\n\twhich\tis\ta\tstrong\trisk\tfactor\tfor\tnoncardia\tgastric\tcancer.\tTraditionally,\ngastric\tcancer\twas\tconsidered\ta\tsingle\tdisease,\tbut\tscientists\tnow\tclassify\tit\tby\tits\tlocation\tin\teither\nthe\ttop\tinch\tof\tthe\tstomach\tnear\tthe\tesophagus\t(gastric\tcardia)\tor\tthe\trest\tof\tthe\tstomach\n(noncardia).
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(noncardia).\nDeveloped\tcountries\thave\tseen\ta\tdecrease\tin\t\nH.\tpylori\n\tinfections\tin\trecent\tyears\tbecause\tof\nincreased\tinformation,\ttesting,\tand\teffective\ttreatment.\tRisk\tfactors\tfor\tthis\tinfection\tare\thigher\tin\nless-developed\tcountries\twith\tlower\tstandard\tof\tliving,\tpoor\teducation,\tand\treduced\tlifespan.\tIn
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treatment\tmust\tbe\tmore\twidespread\t(\nAxon,\t2014\n).\nWhile\tprevalence\tof\t\nH.\tpylori\n\tinfection\tcorrelates\twith\tgeography\tand\tsocioeconomic\tstatus\tof\tthe\npopulation\tand\tbegins\tduring\tchildhood,\tit\n\tis\toften\tnot\tdiagnosed\tuntil\tadulthood.\t\nH.\tpylori\n\tis\tspread
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is\toften\tnot\tdiagnosed\tuntil\tadulthood.\t\nH.\tpylori\n\tis\tspread\nthrough\tcontaminated\tfood\tand\twater\tand\tis\tcorrelated\twith\tlower\tlevels\tof\thygiene.\tMore\tthan\thalf\nof\tthe\tworld\tpopulation\tis\tinfected\tand\tprevalence\tranges\tfrom\tas\tlow\tas\t18.9%\tin\tSwitzerland,\tto\n24.6%–35.6%\tin\tthe\tUnited\tStates\tand\tAustralia,\tto\tas\thigh\tas\t87.7%\tin\tNigeria\t(
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the\tpatient’s\tlifestyle\tand\toverall\thealth.\nIn\tthe\tfirst\tweek\tafter\t\nH.\tpylori\n\tinfection,\tmany\tPMNs\tand\ta\tfew\teosinophils\tinfiltrate\tthe\n\tgastric\nmucosa.\tThese\tare\treplaced\tgradually\twith\tthe\tmononuclear\tcells.\tThe\tpresence\tof\tlymphoid\tfollicles\nis\tcalled\t\nmucosa-associated\tlymphoid\ttissue\t(MALT)\n.\tMALT\tmay\tbecome\tautonomous\tto\tform\ta
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.\tMALT\tmay\tbecome\tautonomous\tto\tform\ta\nlow-grade,\tB-cell\tlymphoma\tcalled\tMALT\tlymphoma.\t\nH.\tpylori\n\tcan\tcause\tduodenitis\tif\tit\tcolonizes\ngastric\ttissue\tthat\tmay\tbe\tpresent\tin\tthe\tduodenum.\nTreating\t\nH.\tpylori\n\twith\tantibiotics\tcan\tcause\tPMNs\n\tto\tdisappear\twithin\ta\tweek\tor\ttwo,\tbut\ta\tmild
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to\tdisappear\twithin\ta\tweek\tor\ttwo,\tbut\ta\tmild\ngastritis\tcan\tpersist\tfor\tseveral\tyears,\tas\tthe\treduction\tin\tmononuclear\tcells\tis\tslow.\tIn\tcountries\nwhere\t\nH.\tpylori\n\tis\tcommon,\tso\tis\tgastric\tcancer.\tBecause\t\nH.\tpylori\n\tcan\tcause\tpeptic\tulcer\tand\tgastric\ncancer,\tantibiotic\ttreatment\tis\tfavored\twhen\tit\tis\tdiagnosed.\t\nBox\t26.6
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Box\t26.6\n\tincludes\tinformation\tabout\nintegrative\tapproaches\tfor\t\nH.\tpylori\n.\nBOX\t26.6\nIntegrative\tApproaches\tto\t\nHelicobacter\tPylori\n\t\nand\tAssociated\nGI\tDisease\nTypical\tmedical\ttreatment\tfor\t\nH.\tpylori\n\tis\twith\t“triple\ttherapy”\t(TT)\tthat\tcombines\ttwo\nantimicrobial\tdrugs\t(clarithromycin\tand\tamoxicillin\tor\tmetronidazole)\twith\tproton\tpump\tinhibitor
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(PPI)\tfor\t1\tto\t2\tweeks\twith\tan\t80%\tto\t85%\tsuccess\trate\t(\nSarkar\tet\tal,\t2016\n;\t\nOh\tet\tal,\t2016\n).\nUnfortunately,\tadverse\tevents\tsuch\tas\t\nClostridium\n\tdifficile\n\tinfection\t(CDI)\tor\tpseudomembranous\ncolitis\tcan\toccur\twith\tthe\tchange\tin\tgut\tflora\tdue\tto\tTT\ttreatment.\tOne\tsmall\trandomized
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to\tbe\tdue\tto\tlowered\nimbalance\tof\tmicrobiota\tduring\ttreatment,\tthus\tleading\tto\tbetter\ttolerated\ttreatment\tcompletion\n(\nOh\tet\tal,\t2016\n).\tWhereas\tthis\tparticular\tstudy\twas\tvery\tsmall,\ta\tmuch\tlarger\tmeta-analysis\nreviewed\tsimilar\tcomparison\tdata\tfrom\t6997\tparticipants\tfrom\t45\tRCTs\tto\tfind\teradication\trates
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of\t82.31%\tin\tthe\tprobiotic\tgroup\tversus\t72.08%\tin\tthe\tcontrol\tgroup\t(\nZhang\tet\tal,\t2015\n).\nProbiotics\n\tspecies\t(\nLactobacillus,\tBifidobacterium\n)\thave\tbeen\tstudied\tfor\tprevention,\nmanagement,\tand\teradication\tof\t\nH.\tpylori\n\t(\nZhu\tet\tal,\t2014\n).\tFurther\tstudy\ton\tspecific\tstrains\tand
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H.\tpylori\n\t(\nZhu\tet\tal,\t2014\n).\tFurther\tstudy\ton\tspecific\tstrains\tand\nlarger\tclinical\ttrials\tis\twarranted\tto\tinvestigate\tthe\trole\tof\tprobiotic\ttherapy\tand\twhether\tit\tshould
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0.11212333291769028, 0.027677634730935097, -0.00933886505663395, -0.007837176322937012, 0.07683952897787094, 0.049252986907958984, -0.08120931684970856, -0.00918527226895094, 0.07682116329669952, 0.007265553809702396, -0.05507153272628784, -0.002348758513107896, 0.1130659207701683, 0.020626632496714592, -0.02340691350400448, -0.03408512845635414, 0.03492413088679314, 0.10051252692937851, 0.044519778341054916, -0.002672791015356779, 0.02489645779132843, 0.04877006262540817, 0.0563051700592041, 0.07013056427240372, -0.018403297290205956 ]
H.\tpylori\neradication\t(\nKennan\tet\tal,\t2010\n).\tRecent\tstudies\thave\talso\tdemonstrated\tanti–\nH.\tpylori\n\tpotential\nand\tsignificant\tinhibition\tof\tthe\tbacteria’s\tgrowth\tby\tn-3\tpolyunsaturated\n\tfatty\tacids\t(PUFAs)\tin\nboth\tin\tvitro\tand\tin\tvivo\tmodels.\tA\tdecrease\tin\tgrowth\tand\tassociated\tinflammation\tof\t\nH.\tpylori
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H.\tpylori\nhas\tbeen\tshown\twith\tadministration\tof\tdocosahexaenoic\tacid\t(DHA).\tAlthough\tsome\tresults\nshowed\tfish\toil\tas\tless\teffective\tthan\taspects\tof\tTT\ttreatment,\tand\tomega-3s\twould\tnot\tbe\ta\nstandalone\ttherapy,\tdata\tsuggests,\twhen\tcombined\twith\tstandard\tTT\ttreatment,\tthat\tPUFAs\tand\nDHA\tcould\n\thave\tpotential\tto\tdamper\trecurrence\trates\t(
[ -0.04938594251871109, -0.023121381178498268, 0.014640958048403263, -0.03223235532641411, -0.09978468716144562, -0.00014843286771792918, 0.07844231277704239, 0.01536463387310505, -0.008631065487861633, 0.04188453406095505, 0.11664098501205444, -0.05522124841809273, 0.016233952715992928, 0.031780436635017395, -0.010070032440125942, 0.028543876484036446, -0.008532946929335594, 0.024316202849149704, -0.03783148154616356, -0.03437546268105507, 0.03803401067852974, 0.07391674816608429, 0.028611181303858757, -0.014395926147699356, 0.005759129766374826, 0.09390895068645477, -0.029169628396630287, 0.004656077828258276, 0.021715810522437096, -0.04203565791249275, -0.09551087021827698, 0.08982639759778976, -0.013553837314248085, -0.02830478921532631, 0.04031267762184143, 0.061842404305934906, -0.09491786360740662, -0.014317134395241737, 0.07199989259243011, 0.029765542596578598, 0.020813938230276108, -0.0711819976568222, -0.03619089350104332, 0.02939315140247345, 0.07584517449140549, 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DHA\tcould\n\thave\tpotential\tto\tdamper\trecurrence\trates\t(\nPark\tet\tal,\t2015\n).\nBecause\tof\tthe\tknown\trelationship\tbetween\t\nH.\tpylori\n\tand\tpeptic\tulcers,\teradication\tof\tthe\nbacteria\tis\ta\tprimary\tfocus\tof\ttreatment\tfor\tthose\twho\ttest\tpositive\tfor\tit.\tDietary\tpolyphenols\tare
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being\treviewed\tin\ta\tvariety\tof\tstudies\tto\tdetermine\tefficacy\tin\tcombination\twith\tconventional\ntreatment\tfor\tpeptic\tulcers.\tPiper\tbetel,\tcurcumin,\n\tgallic\tacid,\tapple,\tgrape,\tpomegranate\tand\ngreen\ttea\tpolyphenols,\tand\tquercetin\trepresent\tonly\ta\tfew\tcompounds\tbeing\tinvestigated.\tThese
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bioactive\tcompounds\tare\tonly\ta\tstarting\tpoint\tfor\tthe\tdirection\tof\tfuture\tresearch\tand\tclinical\ntrials\tneeded\tto\tdetermine\tthe\trole\tof\tfood\tas\ta\tpart\tof\tthe\ttreatment\tfor\tpeptic\tulcer\tdisease\n(\nFarzaei\tet\tal,\t2015\n).\nNon-\nhelicobacter\tpylori\n\tgastritis\nAspirin
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0.051939718425273895, -0.0186832956969738, 0.11618056148290634, 0.0601990632712841, -4.857131230551204e-8, 0.0881425142288208, -0.024264464154839516, 0.00021518727589864284, -0.046367038041353226, 0.024131154641509056, 0.012716604396700859, -0.01399276964366436, 0.04479505494236946, 0.019631629809737206, -0.08329475671052933, -0.01370892021805048, 0.10596170276403427, -0.07708846777677536, -0.0638439729809761, 0.03682662546634674, 0.008662130683660507, -0.062077198177576065, 0.03305196389555931, 0.018277615308761597, -0.0655180960893631, -0.05661049485206604, 0.02909162826836109, -0.0053619761019945145, -0.006515767425298691, 0.03281880542635918, -0.038148220628499985, 0.020122045651078224, -0.03426690027117729, 0.027069220319390297, 0.02199470065534115, 0.06974801421165466, -0.06977606564760208, -0.030807381495833397, -0.0577801950275898, -0.006606270093470812, 0.038633156567811966, -0.02910425327718258, -0.0948624461889267, -0.02223970741033554, 0.11352593451738358, -0.016497725620865822, -0.03826027363538742, -0.05260583758354187, 0.033047694712877274, 0.02818569354712963, -0.04019631817936897, -0.07244507223367691, 0.06044400855898857, 0.00808729138225317, -0.12929530441761017, -0.026416709646582603, 0.05632699280977249, -0.004257875960320234, 0.010226668789982796, -0.08857590705156326, 0.053814709186553955, 0.09867949038743973, -0.05981319397687912, 0.04104800149798393, -0.019851569086313248, -0.010930538177490234, 0.06536650657653809, 0.11551456153392792, 0.051775988191366196 ]
(\nFarzaei\tet\tal,\t2015\n).\nNon-\nhelicobacter\tpylori\n\tgastritis\nAspirin\n\tand\tnonsteroidal\tantiinflammatory\tdrugs\t(NSAIDs)\tare\tcorrosive;\tboth\tinhibit\tprostaglandin\nsynthesis,\twhich\tis\tessential\tfor\tmaintaining\tthe\tmucus\tand\tbicarbonate\tbarrier\tin\tthe\tstomach.\tThus
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chronic\tuse\tof\taspirin\tor\tother\tNSAIDs,\tsteroids,\talcohol,\terosive\tsubstances,\ttobacco,\tor\tany\ncombination\tof\tthese\tfactors\tmay\tcompromise\tmucosal\tintegrity\tand\tincrease\tthe\tchance\tfor\nacquiring\tacute\tor\n\tchronic\tgastritis.\tEosinophilic\tgastroenteritis\t(EGE)\talso\tmay\tcontribute\tto\tsome
[ 0.0019316147081553936, -0.08394193649291992, 0.028643600642681122, 0.0005562840378843248, -0.0951462835073471, 0.03824404999613762, 0.10477015376091003, 0.05623616278171539, -0.03905660659074783, 0.06079103425145149, 0.08935384452342987, 0.008016113191843033, 0.03248784691095352, 0.07206784188747406, -0.04908229783177376, 0.02902221865952015, -0.01582024060189724, 0.01204013917595148, 0.008669189177453518, -0.01989203505218029, 0.011192737147212029, 0.10479096323251724, 0.06834612786769867, -0.052015919238328934, -0.03182269260287285, -0.011116087436676025, -0.00420391047373414, -0.02788154035806656, 0.009940234012901783, -0.03442170470952988, -0.12152843177318573, 0.09600401669740677, -0.03802885487675667, 0.019900891929864883, 0.04180139675736427, -0.057293832302093506, -0.06523938477039337, 0.01900218054652214, 0.08121733367443085, 0.022318363189697266, 0.04520416259765625, -0.0689069926738739, -0.023511506617069244, 0.022434664890170097, 0.018705904483795166, 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-0.10858498513698578, -0.03578568249940872, -0.04173259064555168, 0.031676486134529114, 0.06684193760156631, -0.025618072599172592, 0.0005751881399191916, 0.030344009399414062, 0.05039645731449127, -0.019107172265648842, -0.010614962317049503, -0.12702590227127075, -0.04334622621536255, -0.023865772411227226, -0.00491140503436327, -0.012192907743155956, 0.01299916673451662, -0.019839057698845863, 0.09539936482906342, -0.06903935223817825, -0.11221744865179062, -0.040948286652565, -0.0006533685373142362, -0.03718826547265053, -0.006345776375383139, -0.0037833149544894695, -0.12861588597297668, -0.14240571856498718, 0.021817486733198166, -0.020984085276722908, 0.007408875040709972, -0.016722790896892548, 0.006398268509656191, 0.003315954701974988, -0.051317717880010605, -0.029110370203852654, 0.046007733792066574, 0.01969488151371479, -0.027332069352269173, -0.059247151017189026, -0.01630772091448307, -0.00530537823215127, 0.062356676906347275, 0.07139447331428528, 0.017589638009667397, 0.0542670339345932, -0.053632281720638275, 0.048286277800798416, 0.06236337870359421, -4.540896370031078e-8, 0.07255751639604568, -0.012840702198445797, -0.025157010182738304, -0.04483829811215401, 0.005583066493272781, -0.007497092708945274, 0.010753960348665714, 0.056039392948150635, 0.024711625650525093, -0.01811956614255905, 0.0008970688795670867, 0.11339990049600601, -0.06451883912086487, -0.04940880462527275, 0.08263903856277466, 0.006616574712097645, -0.046874552965164185, 0.059010349214076996, 0.014155270531773567, -0.057991012930870056, -0.03762173280119896, 0.0092819444835186, 0.029094040393829346, 0.009205756708979607, -0.02894197590649128, -0.013963094912469387, 0.023802725598216057, 0.00967356190085411, 0.004838244989514351, 0.02100389264523983, 0.06818358600139618, -0.058208730071783066, -0.04574957117438316, -0.03817940875887871, -0.06546249240636826, 0.03359194099903107, 0.011918948963284492, -0.09022461622953415, 0.004435358103364706, 0.08225397765636444, 0.0008062554989010096, -0.02578442357480526, -0.015233723446726799, 0.03767772018909454, 0.04058055207133293, -0.08047327399253845, -0.0034995083697140217, 0.069717638194561, 0.04606391116976738, -0.1190028041601181, -0.04554060846567154, 0.06400800496339798, 0.0011721079936251044, -0.01994439773261547, -0.06326952576637268, 0.021344447508454323, 0.12942245602607727, 0.004042007960379124, -0.0002467334852553904, -0.03645060956478119, 0.011360368691384792, 0.09853550791740417, 0.09619837254285812, 0.018199047073721886 ]
cases\tof\tgastritis.\tPoor\tnutrition\tand\tgeneral\tpoor\thealth\tmay\tcontribute\tto\tthe\tonset\tand\tseverity\tof\nthe\tsymptoms\tand\tcan\tdelay\tthe\thealing\tprocess.\nMedical\ttreatment\nTreatment\tfor\tgastritis\tinvolves\tremoving\tthe\tinciting\tagent\t(e.g.,\tpathogenic\torganism,\tNSAIDs).\nNoninvasive\tmethods\tfor\tdiagnosing\t\nH.\tpylori\n\tinclude\ta\tblood\ttest\tfor\t\nH.\tpylori
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-0.01038654800504446, 0.03237805888056755, 0.07168841361999512, -4.9412928859737804e-8, 0.010403381660580635, -0.05571849271655083, -0.006963389925658703, -0.06661093235015869, 0.02858789637684822, 0.030068758875131607, 0.03838011622428894, 0.047201693058013916, -0.015432815067470074, -0.04544369503855705, -0.013724585995078087, 0.11881159245967865, -0.05667959526181221, -0.05123436450958252, 0.03909968212246895, -0.01192493550479412, 0.01317466702312231, 0.04808517545461655, -0.010770102962851524, -0.09680213779211044, -0.025778088718652725, 0.04661843553185463, 0.0007844222709536552, -0.037809256464242935, -0.035879459232091904, -0.004752594046294689, -0.018218446522951126, -0.026236683130264282, 0.003056067042052746, 0.031981587409973145, 0.04811849445104599, -0.03790399432182312, -0.020449373871088028, -0.0339842326939106, -0.021445676684379578, 0.023574400693178177, 0.004401810001581907, -0.03532441332936287, 0.014163502492010593, 0.1006464958190918, 0.014672907069325447, 0.02030060440301895, 0.03255840763449669, 0.1033431887626648, 0.030454255640506744, -0.0799327865242958, -0.0036586476489901543, 0.07326905429363251, 0.01721574366092682, -0.09759636223316193, -0.010886630974709988, 0.07773536443710327, 0.006206009071320295, 0.0013028583489358425, -0.05861351639032364, 0.06185033917427063, 0.14741337299346924, 0.058225806802511215, 0.014080234803259373, 0.006460336968302727, 0.06444109231233597, 0.08646095544099808, 0.0685996487736702, 0.023318275809288025 ]
H.\tpylori\n\tinclude\ta\tblood\ttest\tfor\t\nH.\tpylori\n\tantibodies,\ta\turea\nbreath\ttest,\tor\ta\tstool\tantigen\ttest.\t\nEndoscopy\n\tis\ta\tcommon\tinvasive\tdiagnostic\ttool\t(see\t\nFocus\tOn:\nEndoscopy\tand\tCapsules\n\tfor\tmore\tdetails\tabout\tthis\tprocedure).\tAntibiotics\tand\tPPIs\tare\tthe\tprimary\nmedical\ttreatments.
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medical\ttreatments.\nSide\teffects\tof\tchronic\tacid\tsuppression\teither\tfrom\tdisease\tor\tchronic\tuse\tof\tPPIs\tare\ta\tcurrent\ntopic\tof\tinterest\tin\tmedical\n\tresearch.\tFirst\tapproved\tin\t1989,\tPPIs\treduce\tgastric\tacid\tproduction\tby\nbinding\tirreversibly\tto\tthe\thydrogen/potassium\tATPase\tenzyme\ton\tgastric\tparietal\tcells\tand\tare\tnow
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one\tof\tthe\tmost\tcommonly\tprescribed\tmedications\tin\tthe\tUnited\tStates.\tWhile\tthey\tare\tgenerally\nwell-tolerated\tmedications\tand\tare\tconsidered\tsafe,\tthere\thave\tbeen\tsome\temerging\tconcerns\nregarding\tlong-term\tuse\tover\tthe\tpast\n\tseveral\tyears.\tThis\tis\tespecially\ttrue\tfor\tthose\ttaking\tthe
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several\tyears.\tThis\tis\tespecially\ttrue\tfor\tthose\ttaking\tthe\nmedication\tfor\tlonger\tthan\tintended,\tor\twhen\tno\tlonger\tindicated,\tas\tthey\tare\tnow\twidely\tavailable\nover\tthe\tcounter.\tA\tMayo\tClinic\treview\tfound\tthat\tthe\tassociation\tbetween\teach\tof\tthe\thealth\nconcerns\tand\tlong-term\tPPI\tuse\tvaries\tbetween\tlikely\tcausative,\tunlikely\tcausative,\tand\tunclear
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association.\tFor\thypomagnesemia,\tvitamin\tB\n12\n\tdeficiency,\n\tand\tsmall\tintestinal\tbacterial\tovergrowth\n(SIBO)\tthe\tassociation\tis\t\nlikely\tcausative,\n\twhereas\tcommunity\tacquired\tpneumonia\t(CAD)\tis\t\nunlikely\ncausative,\n\tand\tbone\tfractures,\t\nClostridium\tdifficile\n\tinfection,\tchronic\tkidney\tdisease,\tand\tdementia\nhave\tan\t\nunclear\tassociation\n\t(
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have\tan\t\nunclear\tassociation\n\t(\nNehra\tet\tal,\t2018\n).\tSee\t\nAppendix\t13\n\tfor\tnutrients\tof\tconcern\tfor\tthose\ntaking\tthese\tmedications.\nPeptic\tulcers\nEtiology\nNormal\tgastric\tand\tduodenal\tmucosa\tis\tprotected\tfrom\tthe\tdigestive\tactions\tof\tacid\tand\tpepsin\tby\nthe\tsecretion\tof\tmucus,\tthe\tproduction\tof\tbicarbonate,\tthe\tremoval\tof\texcess\tacid\tby\tnormal\tblood
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flow,\tand\tthe\trapid\trenewal\tand\trepair\tof\tepithelial\tcell\tinjury.\t\nPeptic\tulcer\tdisease\n\toccurs\twhen\nopen\tsores\t(peptic\tulcers)\tform\tas\ta\tresult\tof\tthe\tbreakdown\tof\tthe\tnormal\tdefense\tand\trepair\nmechanisms,\n\tand\tare\tdifferentiated\tas\teither\tgastric\tor\tduodenal,\tdepending\ton\tlocation.\tTypically,
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more\tthan\tone\tof\tthe\tmechanisms\tmust\tbe\tmalfunctioning\tfor\tsymptomatic\tpeptic\tulcers\tto\tdevelop.\nPeptic\tulcers\ttypically\tshow\tevidence\tof\tchronic\tinflammation\tand\trepair\tprocesses\tsurrounding\tthe\nlesion.\nThe\tprimary\tcauses\tof\tpeptic\tulcers\tare\t\nH.\tpylori\n\tinfection,\tgastritis,\tuse\tof\taspirin,\tother\tNSAIDs\nand
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H.\tpylori\n\tinfection,\tgastritis,\tuse\tof\taspirin,\tother\tNSAIDs\nand\n\tcorticosteroids,\tand\tsevere\tillness\t(see\t\nStress\tUlcers\n\tlater\tin\tthis\tchapter\tand\t\nPathophysiology\nand\tCare\tManagement\tAlgorithm:\n\tPeptic\tUlcer\n).\tLife\tstress\tmay\tlead\tto\tbehaviors\tthat\tincrease
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0.016887281090021133, -0.023462215438485146, 0.003234516130760312, 0.06141791120171547, 0.048418667167425156, -0.08474531769752502, 0.03464265540242195, 0.05980168655514717, 0.025272494181990623, -0.09886446595191956, -0.02736925706267357, 0.10140674561262131, 0.02984420582652092, -0.014971635304391384, -0.06637143343687057, 0.03304847329854965, 0.11580972373485565, 0.03351334109902382, 0.009049864485859871, -0.029218368232250214, 0.04464570805430412, 0.11582538485527039, 0.0987047329545021, 0.014046397060155869 ]
Peptic\tUlcer\n).\tLife\tstress\tmay\tlead\tto\tbehaviors\tthat\tincrease\npeptic\tulcer\trisk.\tAlthough\texcessive\tuse\tof\tconcentrated\tforms\tof\tethanol\tcan\tdamage\tgastric\nmucosa,\tworsen\tsymptoms\tof\tpeptic\tulcers,\tand\tinterfere\twith\tulcer\thealing,\talcohol\tconsumption\tin\nmoderation\tdoes
[ 0.020255889743566513, -0.11443617194890976, 0.0434197336435318, -0.02255457267165184, -0.1049128994345665, 0.008294116705656052, 0.09657137840986252, -0.010437422432005405, -0.00884953886270523, 0.03460592031478882, 0.11538071185350418, -0.07667993009090424, 0.021859407424926758, -0.00908704288303852, 0.005118330009281635, 0.04633825644850731, -0.002806060016155243, 0.025204714387655258, -0.037739697843790054, -0.0520634688436985, 0.014523527584969997, 0.06820926815271378, 0.03259461745619774, 0.023739000782370567, -0.027846092358231544, 0.01571313850581646, -0.05016561597585678, -0.026425527408719063, 0.003904585260897875, -0.07819339632987976, -0.07887465506792068, 0.07063417136669159, 0.05414414778351784, -0.006684518419206142, 0.045433975756168365, 0.021905427798628807, -0.060747433453798294, 0.004628409631550312, 0.07993674278259277, 0.04307754337787628, -0.010637428611516953, -0.06881342083215714, -0.0617518313229084, 0.034257881343364716, 0.07355452328920364, 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moderation\tdoes\n\tnot\tcause\tpeptic\tulcers\tin\thealthy\tpeople.\tUse\tof\ttobacco\tproducts\talso\tis\tlinked\nwith\tpeptic\tulcer\trisk\tbecause\ttobacco\tdecreases\tbicarbonate\tsecretion\tand\tmucosal\tblood\tflow,\nexacerbates\tinflammation,\tand\tis\tassociated\twith\tadditional\tcomplications\tof\t\nH.\tpylori\n\tinfection.
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H.\tpylori\n\tinfection.\nOther\trisk\tfactors\tinclude\tgastrinoma\tand\tZollinger-Ellison’s\tsyndrome\t(see\t\nChapter\t28\n).\n\t\nFocus\tOn
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Endoscopy\tand\tCapsules\nThe\tesophagogastroduodenoscopy\t(EGD)\tprocedure\tallows\tthe\tmucosa\tof\tthe\tupper\ngastrointestinal\t(GI)\ttract\tto\tbe\tviewed,\tphotographed,\tand\tbiopsied.\tAlso\tknown\tas\tan\tendoscopy,\nthe\tprocedure\tinvolves\tinsertion\tof\ta\tflexible\ttube\tinto\tthe\tesophagus\twith\ta\tlight\tand\tcamera\ton
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the\tdistal\tend.\tIt\tcan\tbe\tpassed\tthrough\tthe\tesophagus\tand\tinto\tthe\tstomach\tor\tupper\tsmall\nbowel.\tInflammation,\terosions,\tulcerations,\tchanges\tin\tthe\tblood\tvessels,\tand\tdestruction\tof\nsurface\tcells\tcan\tbe\tidentified.\tThese\tchanges\tcan\tthen\tbe\tcorrelated\twith\tchemical,\thistologic,
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and\tclinical\tfindings\tto\tformulate\ta\tdiagnosis.\tThis\tmay\tbe\tuseful\twhen\tphysicians\tsuspect\tcertain\nconditions,\tsuch\tas\tcomplicated\tgastroesophageal\treflux\tdisease\t(GERD)\tstrictures,\tBarrett’s\nesophagus\t(BE),\n\tesophageal\tvarices,\tor\tgastroduodenal\tulcers\tor\tceliac\tdisease.
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The\tprocedure\tis\tless\tinvasive\tthan\tnormal\tendoscopy\tand\tprovides\tthe\tadvantage\tof\tbeing\table\tto\nobserve,\trecord,\tand\tmeasure\tGI\tfunction\tas\tthe\tpatient\tis\tambulatory.\nUnfortunately,\tthe\timages\tfrom\tcapsule\tendoscopy\tcan\tbe\tblurred\tby\trapid\tintestinal\ttransit\tor\nlimited\tin\tnumber\tafter
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0.003909706138074398, -0.02203398011624813, 0.019916649907827377, 0.07973964512348175, 0.08223503082990646, -0.07429545372724533, 0.0047839004546403885, 0.06585044413805008, -0.0010013626888394356, -0.11004583537578583, 0.020716149359941483, 0.05972803756594658, -0.0023216623812913895, -0.03758808597922325, -0.03551873192191124, 0.06659746170043945, 0.13511718809604645, 0.01783369481563568, -0.03168855234980583, -0.00014581128198187798, 0.06125852093100548, 0.09716996550559998, 0.06053357198834419, -0.00865765381604433 ]
limited\tin\tnumber\tafter\n\tbattery\tfailure\tin\tcases\tof\tslow\ttransit.\tIn\taddition,\treviewing\tthe\nthousands\tof\timages\tobtained\tafter\teach\tcapsule\tendoscopy\tcan\tbe\tvery\ttime\tconsuming.\nPrototypes\tof\tthe\tnewest\tgeneration\tof\tcapsule\tendoscopy\tallow\tthe\tphysician\tto\tmagnetically
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guide\tthe\tcapsule\tto\ta\tspecific\tlocation\tby\thaving\tthe\tpatient\tlie\ton\ta\tspecial\ttable.\tFuture\ngenerations\tof\tcapsule\tendoscopy\tare\ton\tthe\tdrawing\tboards\n\tto\thopefully\tallow\ttherapeutic\nmeasures\tto\tbe\taccomplished\tin\tthe\tsmall\tbowel\tvia\tcapsule\tendoscopy.
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