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tumor\ton\tthe\tadrenal\tor\tpituitary\tgland.\tWeight\tgain,\tinsulin\tresistance,\thigh\tblood\tsugar,\texcessive\nthirst,\teasy\tbruising,\tdepression,\tmuscle\tloss,\n\tand\tweakness\tare\tcommon\tsymptoms.\tBecause\tcortisol
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causes\tbone\tloss\tover\ttime,\ta\tdiet\trich\tin\tcalcium\tand\tvitamin\tD\tmay\thelp\tprevent\tosteoporosis.\nReducing\tsodium,\toptimal\thydration,\tand\tcaloric\tawareness\tcan\talso\tassist\twith\tweight\tmanagement\nand\tthe\tprevention\tof\tfluid\tretention.\nAddison’s\tdisease\nPrimary\tadrenal\tinsufficiency,\talso\tknown\tas\t\nAddison’s\tdisease\n,\tis\trare.\tIn\tthis\tcondition,
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Addison’s\tdisease\n,\tis\trare.\tIn\tthis\tcondition,\ninsufficient\tsteroid\thormones\tare\tproduced\tin\tspite\tof\tadequate\tlevels\tof\tthe\thormone\nadrenocorticotropic\thormone\t(ACTH).\tPeople\twith\tAddison’s\tdisease\tlose\tthe\tability\tto\tappropriately\nregulate\tblood\tsugar\tand\twill\thave\tlow\tlevels\tof\tcortisol,\taldosterone,\tepinephrine,\tand
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norepinephrine.\tThis\tleads\tto\tloss\tof\tappetite,\tfatigue,\tlow\tblood\tpressure,\tnausea\tand\tvomiting,\tand,\nfor\tsome,\tdarkening\tof\n\tskin\ton\tthe\tface\tand\tneck.\tPatients\twith\tAddison’s\tdisease\thave\tan\tincreased\nneed\tfor\tsalt\tand\twater\tand\talso\tneed\tto\teat\tregular\tbalanced\tmeals\t(with\tlow-glycemic\ncarbohydrate\tand\tprotein)\tto\tregulate\tblood\tsugar.
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carbohydrate\tand\tprotein)\tto\tregulate\tblood\tsugar.\nAdrenal\tinsufficiency/adrenal\tfatigue\nAdrenal\tfatigue\n\thas\tbeen\tidentified\tas\ta\tcollection\tof\tsigns\tand\tsymptoms\tcaused\tby\tthe\tdecreased\nability\tof\tthe\tadrenal\tglands\tto\trespond\n\tadequately\tto\tstress.\tA\tvariety\tof\tterms\tare\tfound\tin\tthe
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adequately\tto\tstress.\tA\tvariety\tof\tterms\tare\tfound\tin\tthe\nscientific\tliterature\tthat\taddress\tadrenal\tfatigue,\tincluding\tsubclinical\tadrenal\tinsufficiency,\tadrenal\nstress,\tadrenal\texhaustion,\tadrenal\tburnout,\tand\tadrenal\timbalance\t(\nAllen\tJr,\t2013\n).\tThe\tadrenals
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Allen\tJr,\t2013\n).\tThe\tadrenals\nare\tthe\ttwo\ttriangular-shaped\tglands\tlocated\tat\tthe\ttop\tof\teach\tkidney\tand\tare\tresponsible\tprimarily\nfor\tgoverning\tthe\tbody’s\tadaptations\n\tto\tstress\tof\tany\tkind.\tUnder\tthe\tinfluence\tof\tstress,\tthe\nadrenals\twill\trespond\twith\tincreased\thormone\tproduction,\twhich\tcan\tcause\televated\tblood\tsugar\tand
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blood\tpressure.\tOver\ttime,\tthe\tadrenal\tcan\tbecome\tdecompensated,\twhere\tthe\thormone\toutput\tmay\nbe\tdiminished.\tThis\tis\toften\treferred\tto\tas\tadrenal\tfatigue.\tThis\tcan\toccur\twhether\tthe\tsource\tof\nstress—physical,\temotional,\tor\tpsychological—is\tchronic\n\tand\tcontinues\tto\tpersist\tcausing\ta
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and\tcontinues\tto\tpersist\tcausing\ta\ncumulative\teffect,\tor\tis\ta\tvery\tintense\tsingle\tevent\tstressor.\tIn\tother\twords,\tthe\tadrenal\tglands\tare\nunable\tto\tkeep\tpace\twith\tthe\tdemands\tof\tperpetual\tfight-or-flight\tarousal,\tresulting\tin\tsubclinical\nadrenal\tdysfunction.\tThe\tmost\tcommon\tsymptoms\tof\tadrenal\tfatigue\tinclude,\tbut\tare\tnot\tlimited\tto,
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excessive\tfatigue\tand\texhaustion,\thair\tloss,\thypoglycemia,\n\thormone\timbalance,\tpoor\tdigestion,\tlow\nimmune\tfunction,\tslow\trecovery\tfrom\tillness,\tinability\tto\tconcentrate,\tand\tinability\tto\tcope\twith\nstressors.\nChronic\tadrenal\tstress\tcauses\tthe\tfollowing\t(\nSun\tet\tal,\t2016\n;\t\nTsigos\tand\tChrousos,\t2002\n):\n•
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Sun\tet\tal,\t2016\n;\t\nTsigos\tand\tChrousos,\t2002\n):\n•\t\nAffects\tcommunication\tbetween\tthe\tbrain\tand\thormone-secreting\tglands.\tThe\thypothalamus\nand\tpituitary\tgland\tdirect\thormone\tproduction,\tincluding\tthat\tof\n\tthe\tthyroid.\tWhen\tthe\nhypothalamus\tand\tpituitary\tweaken\tbecause\tof\tchronic\tadrenal\tstress,\tthey\tare\tnot\table\tto
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communicate\twell\twith\tthe\tthyroid\tgland.\n•\t\nIncreases\tthyroid-binding\tprotein\tactivity,\tso\tthat\tthyroid\thormones\tcannot\tget\tinto\tcells\tto\ndo\ttheir\tjob.\n•\t\nHampers\tthe\tconversion\tof\tT\n4\n\tto\tactive\tforms\tof\tT\n3\n,\twhich\tcan\tlead\tto\tfatigue.\n•\t\nInterferes\twith\tthe\tbiotransformation\t(detoxification)\n\tpathways\tthrough\twhich\tthyroid
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pathways\tthrough\twhich\tthyroid\nhormones\texit\tthe\tbody,\tleading\tto\tthyroid\thormone\timbalance.\n•\t\nCauses\tcells\tto\tlose\tsensitivity\tto\tthyroid\thormones.\n•\t\nWeakens\tthe\timmune\tbarriers\tof\tthe\tdigestive\ttract,\tlungs,\tand\tbrain;\tpromotes\tpoor\nimmune\tregulation.\nThe\timpact\tof\thigh\tstress\ton\tintestinal\tmicroflora\thas\tbeen\texamined\tas\twell.\tA\tsignificant
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decrease\tin\tthe\tnumber\tof\t\nBifidobacteria\n\tand\t\nLactobacilli\n\twas\treported.\tConversely,\tan\tincrease\tin\nthe\tnumber\tof\t\nEscherichia\tcoli\n\tand\tenterobacteria\twere\talso\treported,\tsuggesting\tthat\tthe\tincreased\nchronic\tstress\tdisrupts\tintestinal\tmicroflora\tecology.\tThe\tauthors\tpropose\tis\tthat\tstress\tinduces
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increased\tpermeability\tof\tthe\tgut,\tallowing\tbacteria\tand\tbacterial\tantigens\tto\tcross\tthe\tepithelial\nbarrier\tand\tactivate\ta\tmucosal\timmune\tresponse,\n\twhich\tin\tturn\talters\tthe\tcomposition\tof\tthe\nmicrobiome\tand\tleads\tto\tenhanced\thypothalamic-pituitary-adrenal\t(HPA)\tactivation\t(\nDinan\tand\nCryan,\t2012\n).
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Dinan\tand\nCryan,\t2012\n).\nThese\tare\tsome\tof\tthe\tways\tadrenal\tstress\tdirectly\taffect\tthyroid\tfunction\t(\nHerman\tet\tal,\t2016\n).\nChronic\tadrenal\tstress\taffects\tother\tsystems\tof\tthe\tbody,\twhich\tin\tturn\tdecreases\tthyroid\tfunction.\nFor\texample,\tthe\tadrenal\thormone\t\ncortisol\n\tplays\n\ta\tlarge\trole\tin\tthyroid\thealth.\tCortisol\tis\ta\tlife-
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cortisol\n\tplays\n\ta\tlarge\trole\tin\tthyroid\thealth.\tCortisol\tis\ta\tlife-\nsustaining\thormone\tessential\tto\tthe\tmaintenance\tof\thomeostasis.\tIt\toften\tis\tcalled\tthe\t“stress\nhormone”\tbecause\tit\tinfluences,\tregulates,\tor\tmodulates\tmany\tof\tthe\tchanges\tthat\toccur\tin\tthe\tbody\nin\tresponse\tto\tstress,\tincluding,\tbut\tnot\tlimited,\tto\tthe\tfollowing:\n•
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•\t\nAntiinflammatory\tactions\n•\t\nBlood\tglucose\tlevels\n•\t\nBlood\tpressure\n•\t\nCentral\n\tnervous\tsystem\tactivation\n•\t\nFat,\tprotein,\tand\tcarbohydrate\tmetabolism\tto\tmaintain\tblood\tglucose\n•\t\nHeart\tand\tblood\tvessel\ttone\tand\tcontraction\n•\t\nImmune\tresponses\nCortisol\tlevels\tfollow\ta\tcircadian\trhythm\tand\tnormally\tfluctuate\tthroughout\tthe\tday\tand\tnight,
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compensate\tfor\tand\trecover\tfrom\tthat\tstress.\tWhen\tthis\thappens\trepeatedly,\tit\texhausts\tthe\tadrenal
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and\tthyroid\tglands,\tas\twell\tas\tthe\thypothalamus\tand\tthe\tpituitary\tgland.\tOver\ttime\tthis\texhaustion\nleads\tto\tfunctional\thypothyroidism.\n\tIn\taddition,\tconstant\tcortisol\tproduction\tincreases\trisk\tfor\nobesity\tand\tweakens\tthe\tgastrointestinal\t(GI)\ttract,\tmaking\tone\tmore\tsusceptible\tto\tinflammation,\ndysbiosis\t(poor\tgut\thealth),\tand\tinfection\t(
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dysbiosis\t(poor\tgut\thealth),\tand\tinfection\t(\nFoster,\t2017\n;\t\nvan\tder\tValk\tet\tal,\t2018\n).\nThe\tfollowing\tinclude\tcommon\tintegrative\tinterventions\tin\tthe\ttreatment\tof\tadrenal\tfatigue\t(\nAllolio\net\tal,\t2007\n;\t\nCharmandari,\t2014\n):\n•\t\nB-complex\tvitamins\n\tto\tprovide\tcofactors\tfor\tadrenal\thormone\tproduction\n•\t\nExercise\tin\tmoderation\n•
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•\t\nExercise\tin\tmoderation\n•\t\nLow-glycemic\tload,\tnutrient-dense\tdiet\n•\t\nAntianxiolytic/sedative\tbotanicals\t(i.e.\tchamomile\tand\tlavender)\t(\nHead\tand\tKelly,\t2009\n).\n•\t\nProbiotics\n•\t\nOptimizing\tsleep\thabits\n•\t\nRelaxation\tand\tstress\tmanagement\nOvert\tstressors\tsuch\tas\tchildhood\temotional\tabuse\tand\tposttraumatic\tstress\tdisorder\t(PTSD)\tmay\nresult\tin
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-0.025950945913791656, -0.02602745033800602, 0.02446911856532097, 0.07061833143234253, 0.04957170784473419, -0.07324199378490448, -0.0457264706492424, 0.06863939017057419, 0.00016221609257627279, -0.05325755476951599, 0.03461773693561554, 0.08095760643482208, -0.003623352386057377, -0.005026557482779026, -0.07637286931276321, 0.06939855962991714, 0.07014797627925873, -0.018353449180722237, -0.015389174222946167, 0.005093068350106478, 0.04327419400215149, 0.06345796585083008, 0.06251323223114014, 0.005417452659457922 ]
result\tin\n\tcortisol\thyperactivity,\tthus\tleading\tto\tpituitary\tand\tadrenal\thyperreactivity\tand\tadrenal\nfatigue\tand\tdecompensation\t(\nRasmusson\tet\tal,\t2001\n).\tIncreased\tcortisol\tsignaling,\thowever,\thas\nbeen\tshown\tto\tbe\tneurocognitively\tbeneficial\tin\tdepressed\twomen\twith\ta\thistory\tof\tmaltreatment\n(\nAbercrombie\tet\tal,\t2018\n).\nCLINICAL\tCASE\tSTUDY
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(\nAbercrombie\tet\tal,\t2018\n).\nCLINICAL\tCASE\tSTUDY\nFrank\tis\ta\t72-year-old\tblack\tman\tfrom\tJamaica\twho\tmoved\tto\tthe\n\tUnited\tStates\t2\tyears\tago.\tHe\nhas\tbeen\tdiagnosed\twith\thypothyroidism\tthis\tpast\tyear.\tHe\tcomes\tto\tyour\tclinic\ttaking\tSynthroid,\ngarlic,\tand\tchamomile.\tHis\tdiet\thistory\tindicates\tdaily\tintake\tof\tchicken,\trice,\tcelery,\tgreen
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pepper,\tmango,\tand\tpapaya.\tHe\tstates\tthat\the\thas\tbeen\tvery\ttired\tlately,\thas\tlittle\tenergy,\tand\thas\nconstipation.\tHis\thormone\tlevels\ton\this\tlast\tmedical\treport\twere\tthyroxine\t(T\n4\n):\t1.7\tng/dL,\ntriiodothyronine\t(T\n3\n):\t75\tng/dL,\tand\tthyroid-stimulating\thormone\t(TSH):\t6\tU/mL,\tindicative\tthat\nhis\thypothyroidism\tis\tstill\tnot\twell\tcontrolled.
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his\thypothyroidism\tis\tstill\tnot\twell\tcontrolled.\nNutrition\tdiagnostic\tstatement\n•\t\nFood-medication\tinteraction\trelated\tto\tmixing\tSynthroid\twith\tfoods\tand\therbs\tthat\taggravate\nthyroid\tdysfunction\tas\tevidenced\tby\tfatigue,\tconstipation,\thigh\tTSH,\tand\tlow\tserum\tT\n3\n\tand\nT\n4\n.\nNutrition\n\tcare\tquestions\n1.
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3\n\tand\nT\n4\n.\nNutrition\n\tcare\tquestions\n1.\t\nWhat\tother\tinformation\tdo\tyou\tneed\tfor\ta\tmore\tthorough\tassessment?\n2.\t\nTaking\tinto\tconsideration\this\tJamaican\theritage,\tadvice\twould\tyou\toffer\tFrank\tabout\this\ndiet?\n3.\t\nWhat\tfoods\tand\tsupplements\tconflict\twith\tSynthroid?\n4.
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diet?\n3.\t\nWhat\tfoods\tand\tsupplements\tconflict\twith\tSynthroid?\n4.\t\nBecause\the\tis\ta\trecent\timmigrant,\twhat\tpotential\tstressors\tmay\the\tbe\texperiencing?\nUseful\twebsites\nAmerican\tAssociation\tof\tClinical\n\tEndocrinologists\nAmerican\tThyroid\tAssociation\nEndocrine\tWeb\nThyroid\tDisease\tInformation\nReferences\nAbercrombie\tHC,\tFrost\tCP,\tWalsh\tEC.\tet\tal.
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References\nAbercrombie\tHC,\tFrost\tCP,\tWalsh\tEC.\tet\tal.\t\nNeural\tsignaling\tof\tcortisol,\tchildhood\temotional\nabuse\tand\tdepression-related\tmemory\tbias\n\tBiol\tPsychiatry\tCogn\tNeurosci\tNeuroimaging\n2018;3:\t274-284.\nAllen\tLV\tJr.\t\nAdrenal\tfatigue\n\tInt\tJ\tPharm\tCompd\t2013;17:\t39-44.\nAllolio\tB,\tArlt\tW,\tHahner\tS.
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Int\tJ\tPharm\tCompd\t2013;17:\t39-44.\nAllolio\tB,\tArlt\tW,\tHahner\tS.\t\nDHEA:\twhy,\twhen,\tand\thow\tmuch-DHEA\treplacement\tin\tadrenal\ninsufficiency\n\tAnn\tEndocrinol\t(Paris)\t2007;68:\t268-273.\nAmbali\tSF,\tOrieji\tC,\tAbubakar\tWO.\tet\tal.\t\nAmeliorative\teffect\tof\tVitamin\tC\ton\talterations\tin
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Ameliorative\teffect\tof\tVitamin\tC\ton\talterations\tin\nthyroid\thormone\tconcentrations\tinduced\tby\tsub-chronic\tCo-administration\tof\tChloropyrifos\nand\tLead\tin\twistar\trats\n\tJ\tThyroid\tRes\t2011;\t214924.\nAmerican\tThyroid\tAssociation:\t\nThyroid\tdisease\tand\n\tpregnancy\n\t(website).\nhttp://www.thyroid.org/thyroid-disease-and-pregnancy/\n.
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(website).\nhttp://www.thyroid.org/thyroid-disease-and-pregnancy/\n.\nAmin\tAl,\tHegazy\tNM,\tIbrahim\tKS.\tet\tal.\t\nThyroid\thormone\tindices\tin\tcomputer\tworkers\twith\nemphasis\ton\tthe\trole\tof\tZinc\tsupplementation\n\tOpen\tAccess\tMaced\tJ\tMed\tSci\t2016;4:\t296-301.\nBaeke\tF,\tTakiishi\tT,\tKorf\tH.\tet\tal.\t\nVitamin\tD:\tmodulator\tof\tthe\timmune\tsystem\n\tCurr\tOpin
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Vitamin\tD:\tmodulator\tof\tthe\timmune\tsystem\n\tCurr\tOpin\nPharmacol\t2010;10:\t482-496.\nBajaj\tJK,\tSalwan\tP,\n\tSalwan\tS.\t\nVarious\tpossible\ttoxicants\tinvolved\tin\tthyroid\tdysfunction:\ta\nreview\n\tJ\tClin\tDiagn\tRes\t2016;10:\tFE01-\tFE03.\nBarker\tJM,\tLiu\tE.\t\nCeliac\tdisease:\tpathophysiology,\tclinical\tmanifestations,\tand\tassociated\nautoimmune\tconditions
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autoimmune\tconditions\n\tAdv\tPediatr\t2008;55:\t349-365.
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31\nMedical\tnutrition\ttherapy\tfor\nanemia\nMichelle\tLoy,\tMPH,\tMS,\tRDN\nKEY\tTERMS\nanemia\naplastic\tanemia\nceruloplasmin\nferritin\nferroprotein\nglossitis\nhematocrit\nheme\tiron\nhemoglobin\nhemolytic\tanemia\nhepcidin\nhereditary\themochromatosis\nolotranscobalamin\tII\t(holo\tTCII)\nhypochromic\nintrinsic\tfactor\t(IF)\niron\tdeficiency\tanemia\nkoilonychia\nmacrocytic\tanemia
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iron\tdeficiency\tanemia\nkoilonychia\nmacrocytic\tanemia\nmeat-fish-poultry\n\t(MFP)\tfactor\nmegaloblastic\tanemia\nmicrocytic\tanemia\nnonheme\tiron\nnormochromic\nnutritional\tanemias\npagophagia\npernicious\tanemia\npica\nplasma\npolycythemia\nprotoporphyrin\nreticulocytosis\nrestless\tlegs\tsyndrome\t(RLS)\nserum\nsickle\tcell\tdisease\t(SCD)
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restless\tlegs\tsyndrome\t(RLS)\nserum\nsickle\tcell\tdisease\t(SCD)\nsideroblastic\t(pyridoxine-responsive)\tanemia\nsoluble\tserum\ttransferrin\treceptors\t(STFRs)\nsports\tanemia\nthalassemia\ntotal\tiron-binding\n\tcapacity\t(TIBC)
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transferrin\ntransferrin\treceptor\ntransferrin\tsaturation\nAnemia\n\tis\tthe\tpredominant\thematologic\tdisorder\tin\tthe\tUnited\tStates\tand\tis\tassociated\twith\tmedical\nconsequences\tthat\tinfluence\tmorbidity\tand\tmortality.\tAnemia\taffects\t5.6%\tof\tthe\tnation’s\tpopulation\nwith\tthe\tprevalence\tbeing\thighest\tamong\twomen\tof\treproductive\tage,\tadults\t60\tyears\tor\tolder,
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blacks,\tand\tHispanics\t(\nLe,\t2016\n).\tAnemia\tis\talso\ta\tserious\tglobal\thealth\tburden\taffecting\t2\tbillion\npeople\tworldwide\twith\tthe\thighest\trates\toccurring\tin\tSouth\tAsia\tand\tcentral\tand\twest\tsub-Saharan\nAfrica\t(\nKassebaum,\t2016\n).\tGlobally,\tyoung\tchildren,\twomen,\tand\tolder\tadults\tare\tat\thighest\trisk\tof
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developing\tanemia.\tTo\tbest\taddress\tthis\tserious\thealth\tproblem,\tnutrition\tprofessionals\tneed\ta\tsolid\nunderstanding\tof\tthe\trelevant\tterminology\n\talong\twith\tthe\tetiology,\tpathophysiology,\tand\tmedical\tand\nnutritional\tmanagement\tof\tthe\tmost\tcommon\ttypes\tof\tanemia.\nHemoglobin
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nutritional\tmanagement\tof\tthe\tmost\tcommon\ttypes\tof\tanemia.\nHemoglobin\n\tis\ta\tconjugated\tprotein\tcontaining\tfour\theme\tgroups\tand\tglobin;\tit\tis\tthe\toxygen-\ncarrying\tpigment\tof\tthe\terythrocytes.\tThe\t\nhematocrit\n\tis\tthe\tvolume\tpercentage\tof\terythrocytes\tin\nthe\tblood.\t\nPlasma\n\tis\tthe\tliquid\tportion\tof\twhole\tblood\tcontaining\tcoagulation\tfactors;\t\nserum
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serum\n\tis\tthe\nliquid\tportion\tof\twhole\tblood\twithout\tcoagulation\tfactors.\nAnemia\tis\ta\tdeficiency\tin\tthe\tsize\tor\tnumber\tof\tred\tblood\tcells\t(RBCs)\tor\tthe\tamount\tof\themoglobin\nthey\tcontain.\tThis\tdeficiency\tlimits\tthe\texchange\tof\toxygen\tand\tcarbon\tdioxide\tbetween\tthe\tblood
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and\tthe\ttissue\tcells.\tAnemia\tclassification\tis\tbased\ton\tcell\tsize—macrocytic\t(large),\tnormocytic\n(normal),\tand\tmicrocytic\t(small)—and\n\ton\themoglobin\tcontent:\t\nhypochromic\n\t(pale\tcolor\tfrom\ndeficiency\tof\themoglobin)\tand\t\nnormochromic\n\t(normal\tcolor)\t(\nTable\t31.1\n).
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-0.005085744429379702, -0.02745428867638111, 0.04804981127381325, 0.0861973837018013, -4.5539618298562345e-8, 0.10986620932817459, -0.048623476177453995, -0.05403558909893036, -0.046104345470666885, 0.02218453586101532, -0.005653816275298595, -0.04485649615526199, 0.06980360299348831, 0.029849059879779816, 0.006212386302649975, 0.023180175572633743, 0.0733279138803482, -0.07289823889732361, -0.0275851022452116, 0.09109388291835785, 0.012082846835255623, -0.033414147794246674, 0.010952952317893505, -0.008955241180956364, -0.11276966333389282, -0.011159149929881096, 0.013828309252858162, 0.021776041015982628, 0.001109991455450654, -0.029433026909828186, -0.021634172648191452, 0.004461836069822311, -0.01887432485818863, 0.03729064762592316, 0.04422968626022339, 0.03263843059539795, 0.0037810823414474726, 0.006676324177533388, -0.0188473891466856, -0.03790787607431412, 0.011207591742277145, -0.04093560948967934, 0.020481372252106667, -0.04055538773536682, 0.014538274146616459, -0.04154445230960846, -0.07557900249958038, -0.08045187592506409, 0.06541433930397034, 0.11594751477241516, -0.0826328918337822, 0.03148796409368515, 0.06267800182104111, 0.0009919010335579515, -0.06651965528726578, -0.025490954518318176, 0.07896710187196732, -0.017646940425038338, -0.013741733506321907, -0.08304797112941742, 0.060721419751644135, 0.0531032457947731, -0.0001587137667229399, 0.0022366242483258247, -0.03965558111667633, 0.015148963779211044, 0.04787618666887283, 0.04394581541419029, -0.05392332747578621 ]
TABLE\t31.1\nMorphologic\tClassification\tof\tAnemia\nMorphologic\nType\tof\nAnemia\nUnderlying\nAbnormality\nClinical\tSyndromes\nTreatment\nMacrocytic\t(MCV\t>\t94;\tMCHC\t>\t31)\nMegaloblastic\nVitamin\tB\n12\ndeficiency\nPernicious\tanemia\nVitamin\tB\n12\nFolate\tdeficiency\nNutritional\tmegaloblastic\nanemias,\tmalabsorption\nsyndromes\nFolic\tacid\nInherited\ndisorders\tof
[ -0.013679643161594868, -0.05664554983377457, 0.004770007450133562, -0.006728406064212322, -0.04815620929002762, -0.007686343975365162, 0.03288722783327103, 0.11204192787408829, -0.09954000264406204, 0.04033161699771881, 0.05957632139325142, -0.008464806713163853, 0.013944264501333237, -0.011804597452282906, -0.08032431453466415, -0.03710682690143585, -0.01787579245865345, 0.010147112421691418, -0.03821711242198944, 0.042283933609724045, -0.037628740072250366, 0.08854735642671585, 0.014068038202822208, 0.013166007585823536, 0.0422908216714859, -0.029996328055858612, -0.009762481786310673, -0.009626210667192936, -0.019385764375329018, 0.02145850658416748, -0.11375441402196884, 0.06268421560525894, 0.02319554053246975, -0.005713670514523983, 0.06069640442728996, -0.01371818594634533, -0.03637629747390747, 0.025809625163674355, -0.0640106275677681, 0.03193553164601326, -0.0064070881344377995, -0.125296488404274, -0.032833922654390335, 0.014564291574060917, 0.05234227329492569, -0.0693637803196907, -0.04780097305774689, -0.07449467480182648, 0.004558667074888945, 0.09576524049043655, -0.07765179872512817, -0.04317314550280571, -0.08822189271450043, 0.03476855531334877, 0.0250506903976202, -0.058369483798742294, -0.1051022857427597, -0.057851437479257584, -0.056473031640052795, 0.009241921827197075, -0.01766437664628029, -0.058151356875896454, 0.026865549385547638, -0.007464507129043341, 0.06942762434482574, 0.1085975170135498, 0.06138145923614502, -0.033980678766965866, -0.0020541581325232983, 0.040019113570451736, 0.0837024673819542, -0.015696093440055847, -0.05605483427643776, 0.08587586879730225, -0.03301967680454254, -0.0011736522428691387, 0.03150366619229317, -0.013560011051595211, -0.011663164012134075, 0.006755637004971504, -0.08310297876596451, 0.08881327509880066, -0.02606738545000553, -0.00550470594316721, 0.026500442996621132, 0.02884889580309391, -0.039126042276620865, 0.05240590497851372, -0.023806700482964516, 0.030461838468909264, 0.019698619842529297, 0.05366279184818268, 0.04460154101252556, 0.020145202055573463, -0.04147663339972496, -0.011143145151436329, 0.027161236852407455, -0.0967927947640419, 0.05322777479887009, -0.025813641026616096, -0.05686745420098305, -0.04487484320998192, 0.00012337524094618857, 0.06558669358491898, -0.022307107225060463, -0.040094226598739624, 0.014826258644461632, -0.037829868495464325, 0.007784676738083363, 0.027498256415128708, 0.025096487253904343, 0.056137558072805405, 0.04678785055875778, -0.10244236886501312, -0.001029842533171177, -0.023416541516780853, 0.003534478833898902, 0.02307017892599106, 0.11386679112911224, 0.06597750633955002, -0.02013929933309555, -0.029607677832245827, 0.038854196667671204, -0.0046728383749723434, -0.05813403055071831, -0.04940993711352348, -0.03647013381123543, 3.4158297284621296e-33, 0.03249287232756615, 0.015506839379668236, 0.042438555508852005, 0.09112334996461868, 0.03469054400920868, 0.04640093445777893, 0.013089212588965893, -0.06167425215244293, -0.01692686229944229, 0.007892544381320477, -0.09080655127763748, 0.034893691539764404, 0.06116689741611481, 0.044054970145225525, -0.03955189138650894, 0.0163999255746603, -0.04225478321313858, 0.0024521967861801386, -0.038343895226716995, 0.0008170822402462363, 0.013096692971885204, 0.09542551636695862, 0.03010384365916252, 0.04811796918511391, -0.061304669827222824, -0.0009952968684956431, -0.07516493648290634, -0.009789363481104374, 0.015726806595921516, 0.030337443575263023, -0.011562192812561989, -0.06151200085878372, -0.0015465738251805305, -0.13175170123577118, -0.03343801572918892, -0.01573820225894451, -0.029559949412941933, 0.061043743044137955, 0.023730767890810966, 0.03085501305758953, -0.0360226072371006, -0.01736024022102356, -0.023526882752776146, 0.03717777132987976, 0.06581903249025345, -0.056988395750522614, 0.03708310052752495, -0.021664779633283615, -0.06339961290359497, -0.0539509654045105, -0.038112934678792953, -0.029768258333206177, 0.043402303010225296, -0.027487952262163162, -0.024936474859714508, -0.01867840439081192, -0.03793421760201454, 0.04213469475507736, -0.06634989380836487, 0.11473398655653, 0.08733558654785156, 0.009466275572776794, 0.017885830253362656, -0.018354183062911034, 0.0057302201166749, -0.014262608252465725, -0.14314121007919312, -0.05370449274778366, -0.007009911350905895, -0.00554637610912323, 0.02184811607003212, 0.008160039782524109, -0.0036203800700604916, 0.000917628058232367, 0.08328607678413391, 0.008474222384393215, -0.03320499509572983, -0.0062856837175786495, -0.0450337678194046, -0.09714246541261673, -0.0028234405908733606, -0.01242151577025652, 0.00048400412197224796, 0.04450056701898575, -0.07683749496936798, 0.01094008143991232, -0.016027767211198807, -0.03938960283994675, -0.0025695906952023506, -0.08850310742855072, -0.009265816770493984, 0.025721048936247826, -0.033201370388269424, -0.06905177235603333, -0.06315433979034424, -5.733527695407448e-33, -0.026009274646639824, 0.025669040158391, -0.03889700397849083, -0.031556636095047, -0.005376886576414108, -0.01219151820987463, 0.034989140927791595, 0.03625616803765297, 0.047492094337940216, 0.003167912131175399, 0.10062964260578156, 0.013094054535031319, -0.10824468731880188, -0.12601478397846222, -0.1336480975151062, 0.06258582323789597, -0.022772787138819695, 0.10414116084575653, -0.0407671220600605, -0.027129845693707466, -0.0398319773375988, 0.06296024471521378, -0.05904946103692055, 0.03909825533628464, -0.008051245473325253, 0.0948711559176445, -0.07589408755302429, -0.009989104233682156, 0.03008868172764778, 0.050927259027957916, 0.018977953121066093, -0.005254112649708986, -0.004604864865541458, 0.002428423147648573, 0.0045448848977684975, -0.00905927736312151, 0.004044282250106335, -0.06217483803629875, -0.03255901858210564, 0.00785614550113678, 0.04176774621009827, -0.025871990248560905, 0.07848259061574936, -0.0006433455855585635, 0.03833115100860596, -0.01453864574432373, 0.04927083104848862, -0.004963216837495565, 0.03178471326828003, 0.030504681169986725, 0.06292039901018143, 0.022718340158462524, -0.027288924902677536, 0.10576914250850677, 0.06411954015493393, -0.030525224283337593, 0.005204177927225828, -0.06795632094144821, -0.07914894819259644, -0.02203311212360859, -0.008193913847208023, -0.025646083056926727, 0.018652526661753654, -0.002860031323507428, 0.05912168323993683, -0.026975244283676147, -0.020254043862223625, -0.02989555522799492, 0.012640180066227913, -0.027002690359950066, -0.016339901834726334, -0.03318030759692192, -0.05686303228139877, -0.14319007098674774, 0.05574864521622658, -0.025014620274305344, 0.02425941452383995, 0.036715950816869736, -0.030017152428627014, -0.047864001244306564, -0.055677980184555054, -0.11425842344760895, 0.03122739866375923, 0.042460571974515915, -0.04360537230968475, -0.03626749664545059, 0.034391842782497406, -0.0862465426325798, 0.03141278401017189, 0.06881782412528992, -0.05597609654068947, -0.006980415433645248, -0.039516013115644455, 0.09675287455320358, 0.05765582248568535, -4.4730807502446623e-8, 0.10452501475811005, 0.0008070439798757434, -0.08110306411981583, -0.08420384675264359, 0.032938580960035324, -0.02346142567694187, -0.0996226891875267, 0.08268606662750244, 0.06374125182628632, 0.015071818605065346, -0.013640566729009151, 0.0950286015868187, -0.10002745687961578, -0.03537406399846077, 0.02192401885986328, 0.027225155383348465, 0.010730081237852573, 0.10273224115371704, -0.0008819655049592257, -0.03996071591973305, -0.05316207557916641, -0.008522716350853443, 0.010888075456023216, -0.01925423927605152, -0.006592281628400087, -0.01710045151412487, -0.016450515016913414, 0.00031396085978485644, 0.05952494218945503, 0.004894961137324572, 0.06506793946027756, -0.03709324076771736, 0.028606893494725227, -0.03277922421693802, -0.04817282035946846, 0.026891013607382774, -0.026135144755244255, -0.019999556243419647, -0.032040514051914215, 0.06697756797075272, -0.044550538063049316, -0.06609392166137695, -0.030474888160824776, 0.08135487139225006, 0.07202919572591782, -0.019837329164147377, -0.04941263422369957, 0.08747756481170654, 0.049369391053915024, -0.11389850080013275, -0.03525654971599579, 0.035388439893722534, -0.019467217847704887, -0.008243325166404247, -0.09066645056009293, 0.11210144311189651, 0.11554539203643799, 0.025997454300522804, 0.053312912583351135, -0.001388119999319315, 0.07856394350528717, 0.05122222751379013, 0.046573054045438766, -0.013366632163524628 ]
anemias,\tmalabsorption\nsyndromes\nFolic\tacid\nInherited\ndisorders\tof\nDNA\tsynthesis\nOrotic\taciduria\nSickle\tcell\tdisease\nTreatment\tbased\ton\tthe\tnature\tof\nthe\tdisorder\nDrug-induced\ndisorders\tof\nDNA\tsynthesis\nSide\teffects\tof\nchemotherapeutic\tagents,\nanticonvulsants,\toral\ncontraceptives\nDiscontinue\toffending\tdrug\tand\nadminister\tfolic\tacid
[ -0.05105661600828171, -0.07075865566730499, 0.012166633270680904, 0.005612404551357031, -0.08782227337360382, 0.020174872130155563, 0.008913329802453518, 0.03679044172167778, -0.047540225088596344, 0.10498882830142975, 0.11931120604276657, -0.021802393719553947, 0.02465750277042389, 0.01147189736366272, -0.09673888981342316, 0.021585950627923012, -0.05702820047736168, 0.017177721485495567, -0.02014385722577572, 0.014377869665622711, -0.016221540048718452, 0.1353021115064621, 0.0793800950050354, 0.002056581201031804, 0.0260772667825222, -0.08496474474668503, -0.041289620101451874, -0.016888706013560295, -0.029543034732341766, -0.048562753945589066, -0.0945553109049797, 0.03352305293083191, -0.002335253404453397, 0.018314730376005173, 0.048959095031023026, 0.0033027685713022947, 0.0032127981539815664, 0.03014351986348629, 0.05703761428594589, 0.030403871089220047, 0.052005548030138016, -0.07644131034612656, -0.04206320643424988, 0.057722508907318115, 0.00276878266595304, 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-0.03995894268155098, -0.05979549512267113, 0.04301987960934639, 0.002501634182408452, -0.057002972811460495, 0.0037158250343054533, 0.054873380810022354, -0.06535834819078445, 0.02610364556312561, -0.07888127118349075, -0.05694573372602463, -0.0503387525677681, -0.022296782582998276, 0.014058089815080166, 0.0007578041986562312, 0.009081995114684105, -0.0834338366985321, -0.10504860430955887, 0.0016184914857149124, -0.01388594787567854, 0.01135439332574606, 0.03481784462928772, 0.07372798770666122, -0.053652867674827576, 0.03185192868113518, -0.03564399108290672, 0.028687676414847374, 0.007757617626339197, 0.1086377426981926, 0.07714446634054184, -0.02465733140707016, -0.04122907295823097, 0.06394463777542114, 0.022511865943670273, -0.027049152180552483, -0.031949568539857864, -0.03840211406350136, 3.306855157327165e-33, 0.0639827623963356, 0.019066832959651947, 0.01575760543346405, 0.11951030045747757, 0.024870939552783966, 0.054930996149778366, -0.04495212435722351, 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contraceptives\nDiscontinue\toffending\tdrug\tand\nadminister\tfolic\tacid\nNonmegaloblastic\nAccelerated\nerythropoiesis\nHemolytic\tanemia\nTreatment\tof\tunderlying\tdisease\nHypochromic\tMicrocytic\t(MCV\t<\t80;\tMCHC\t<\t31)\nIron\tdeficiency\nChronic\tloss\tof\n\tblood,\ninadequate\tdiet,\timpaired\nabsorption,\tincreased\ndemands\nFerrous\tsulfate\tor\tferrous\tbis
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absorption,\tincreased\ndemands\nFerrous\tsulfate\tor\tferrous\tbis\nglycinate\tand\tcorrection\tof\nunderlying\tcause\nDisorders\tof\nglobin\nsynthesis\nThalassemia\nHemoglobin\tE\nHemoglobin\tC\nNonspecific\nMild\t–\tdoes\tnot\trequire\ntreatment;\nSevere\t–\tfrequent\tblood\ntransfusions\tto\tprovide\nhealthy\tRBCs\twith\tnormal\nHgb\nDisorders\tof\nporphyrin\tand\nheme\nsynthesis
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Hgb\nDisorders\tof\nporphyrin\tand\nheme\nsynthesis\nPyridoxine-responsive\n\tanemia\nPyridoxine\nOther\tdisorders\nof\tiron\nmetabolism\nCopper\tdeficiency\nCopper\nNormochromic\tNormocytic\t(MCV\t82-92;\tMCHC\t>\t30)\nRecent\tblood\tloss\nVarious\nTransfusion,\tiron,\tcorrection\tof\nunderlying\tcondition\nOverexpansion\tof\nplasma\tvolume\nEdema\tof\tpregnancy\nRestore\thomeostasis
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Overexpansion\tof\nplasma\tvolume\nEdema\tof\tpregnancy\nRestore\thomeostasis\nHemolytic\ndiseases\nOverhydration\nTreatment\tbased\ton\tthe\tnature\tof\nthe\tdisorder\nHypoplastic\tbone\nmarrow\nAplastic\tanemia\nPure\tRBC\taplasia\nTransfusion\nAndrogens\nInfiltrated\tbone\nmarrow\nLeukemia,\tmultiple\tmyeloma,\nmyelofibrosis\nChemotherapy\nEndocrine\nabnormality
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myelofibrosis\nChemotherapy\nEndocrine\nabnormality\nHypothyroidism,\tadrenal\ninsufficiency\nTreatment\tof\tunderlying\tdisease\nChronic\tdisease\nTreatment\tof\tunderlying\tdisease\nRenal\tdisease\nRenal\tdisease\nTreatment\tof\tunderlying\tdisease\nLiver\tdisease\nCirrhosis\nTreatment\tof\tunderlying\n\tdisease\nDNA,\n\tDeoxyribonucleic\tacid;\t\nMCHC,
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-0.032197266817092896, -0.00721695413812995, -0.051640383899211884, -0.05344768613576889, 0.04459774121642113, 0.0647534728050232, 0.08106490969657898, 0.05897800996899605, -0.0207357294857502, 0.0709802657365799, -0.019563449546694756, -0.08753504604101181, -0.12989793717861176, -0.07454434037208557, -0.012435917742550373, -0.029586900025606155, 0.07992000132799149, 0.03565021604299545, 0.03311103582382202, -0.04756540060043335, 0.07425849884748459, -0.08868977427482605, 0.09072970598936081, 0.04484597593545914, 0.05592799931764603, -0.06531377136707306, 0.042667921632528305, 0.05027413368225098, 0.04124421626329422, -0.013495341874659061, 0.02448132075369358, 0.0028039496392011642, -0.022292926907539368, 0.03164982795715332, 0.03499261289834976, 0.03276406228542328, -0.03249073028564453, 0.007444628980010748, -0.037946656346321106, 0.016705287620425224, -0.007585067301988602, 0.07149706780910492, 0.025781558826565742, 0.08008457720279694, -0.014552416279911995, -0.04730707034468651, 0.05815945938229561, 0.0507001131772995, 0.05179847404360771, -0.0017491145990788937, 0.02395406924188137, -0.05560425668954849, 0.06292536854743958, 0.07262683659791946, -0.10234473645687103, 0.0033931639045476913, -0.06739944964647293, -0.06759895384311676, -0.0034302484709769487, 0.004108860157430172, -0.03469683974981308, -0.015352454036474228, 0.04041415452957153, 0.02501094527542591, 0.011128313839435577, -0.08703248202800751, -0.0491858534514904, 0.017694272100925446, 0.04908592253923416, -0.031406253576278687, -0.005491412244737148, -0.04792949557304382, -0.0732310563325882, 0.07165942341089249, 0.0011567024048417807, 0.004409991204738617, 0.0025085622910410166, 0.0012967290822416544, -0.0258155670017004, -0.021353740245103836, -0.06952126324176788, 0.03205288201570511, 0.012297564186155796, 0.009778372943401337, -0.07478967308998108, 0.05034617334604263, -0.006196913309395313, 0.02955947443842888, -0.03826236352324486, -0.00204310636036098, 0.01321206334978342, -0.0604105219244957, 0.03318287432193756, -0.0005971344071440399, -4.14710186191769e-8, 0.08551780879497528, -0.027700088918209076, 0.006125261541455984, -0.13719505071640015, 0.08678567409515381, -0.02936437912285328, -0.020780624821782112, 0.029030844569206238, 0.09048488736152649, -0.0036254683509469032, 0.008257003501057625, 0.05844758078455925, -0.029557667672634125, -0.01474006474018097, 0.06804176419973373, 0.0010570012964308262, 0.035406604409217834, 0.08135729283094406, 0.011318845674395561, -0.05124206095933914, -0.02751840651035309, 0.0007886581588536501, -0.015876105055212975, -0.010933510959148407, 0.00695958873257041, 0.006194181274622679, 0.04087136313319206, -0.035679712891578674, 0.003026105696335435, 0.007933891378343105, 0.06619549542665482, -0.032846543937921524, 0.011233490891754627, -0.06921697407960892, -0.06381136924028397, 0.02194586955010891, -0.002133892849087715, -0.030546346679329872, 0.020403407514095306, 0.0434861034154892, 0.00434971833601594, 0.0009649618878029287, 0.0010159419616684318, 0.046443577855825424, 0.08929826319217682, -0.028900446370244026, 0.011166652664542198, 0.03480890765786171, 0.050229668617248535, -0.15367436408996582, -0.03824799507856369, 0.026388216763734818, -0.019332878291606903, -0.04902410879731178, -0.06081340089440346, 0.1017821803689003, 0.109717458486557, 0.01436432171612978, 0.00599555904045701, -0.019606437534093857, 0.07365657389163971, 0.0861855298280716, 0.07888790220022202, 0.0089744683355093 ]
Treatment\tof\tunderlying\n\tdisease\nDNA,\n\tDeoxyribonucleic\tacid;\t\nMCHC,\n\tmean\tcorpuscular\themoglobin\tconcentration:\tconcentration\tof\themoglobin\texpressed\tin\tgrams\tper\tdeciliter\n(g/dL);\t\nMCV,\n\tmean\tcorpuscular\tvolume:\tvolume\tof\tone\tred\tblood\tcell\texpressed\tin\tfemtoliters\t(fl);\t\nRBC\n,\tred\tblood\tcell.\nModified\tfrom\tWintrobe\tMM\tet\tal:
[ -0.05713033676147461, -0.08377186208963394, 0.006017675157636404, -0.11915150284767151, -0.1100769191980362, 0.006551968399435282, 0.04007803648710251, 0.03600737452507019, -0.04905932769179344, 0.06545381247997284, 0.12749305367469788, 0.02768133580684662, 0.0013024666113778949, 0.016579100862145424, -0.09777278453111649, 0.01932656019926071, -0.024798642843961716, 0.07205279171466827, -0.049112193286418915, -0.06985924392938614, 0.01618460938334465, 0.11285337060689926, 0.05578091740608215, 0.009726599790155888, 0.03255979344248772, -0.021243654191493988, -0.06378660351037979, -0.013354459777474403, 0.01464560255408287, -0.1042751893401146, -0.06538075953722, 0.058146897703409195, -0.030578264966607094, 0.010930236428976059, 0.00801690574735403, 0.053053442388772964, -0.017984332516789436, -0.009185424074530602, 0.02346791699528694, 0.0016522725345566869, 0.06992243230342865, -0.0785883292555809, -0.05390783026814461, 0.04174897074699402, 0.01243483368307352, -0.0030471819918602705, -0.04797621816396713, 0.015980327501893044, -0.022878913208842278, 0.026289544999599457, 0.0002844518458005041, -0.028174104169011116, -0.0609593503177166, 0.07291482388973236, 0.00032004970125854015, -0.014246182516217232, -0.071294866502285, -0.06361407041549683, 0.029299810528755188, 0.03678566962480545, -0.04085838049650192, -0.022545667365193367, -0.072657011449337, 0.03277740627527237, 0.0704004317522049, 0.016216028481721878, 0.054018761962652206, -0.03179692476987839, 0.02010439708828926, 0.008686981163918972, -0.0023694124538451433, 0.011788301169872284, -0.06004592776298523, 0.1334836333990097, -0.06809008866548538, 0.08551441878080368, 0.05692516267299652, -0.03119766339659691, 0.05790795758366585, -0.028250357136130333, -0.10034510493278503, 0.07319262623786926, 0.0631786659359932, 0.09852295368909836, -0.008442607708275318, 0.03094937838613987, -0.09409120678901672, 0.06017230823636055, -0.02423020638525486, 0.04542069509625435, 0.039580803364515305, -0.019640140235424042, 0.011638074181973934, -0.0018061277223750949, -0.07753898203372955, -0.037493277341127396, 0.08330332487821579, 0.004428785759955645, 0.025302352383732796, -0.02176724001765251, -0.012318035587668419, -0.029713772237300873, 0.039926718920469284, -0.04134725034236908, -0.06591463088989258, -0.05316828563809395, -0.04091992601752281, -0.04665518179535866, 0.04477638751268387, -0.04747447744011879, -0.017681773751974106, 0.011203658767044544, 0.08629019558429718, -0.06108604371547699, -0.031947724521160126, -0.0019045461667701602, -0.011857368052005768, 0.011028716340661049, 0.12254096567630768, 0.014279847964644432, -0.0181024968624115, -0.0384976826608181, -0.011913242749869823, 0.05052635446190834, -0.021714450791478157, -0.044197920709848404, 0.0027370359748601913, 2.701457750567432e-33, 0.022394346073269844, 0.03399991616606712, 0.021023433655500412, 0.13991707563400269, 0.007385697215795517, 0.04499258100986481, -0.08589087426662445, -0.07039361447095871, -0.1210017129778862, 0.03504941239953041, -0.050756290555000305, -0.0397353395819664, 0.01588490791618824, 0.10279136151075363, -0.04456554725766182, -0.09166201949119568, -0.007308383472263813, 0.03160705044865608, -0.04059731215238571, -0.006864483468234539, -0.024699630215764046, 0.15030410885810852, 0.017408272251486778, 0.021921858191490173, -0.02118098922073841, 0.008396592922508717, -0.07411247491836548, 0.0049184043891727924, 0.06889598816633224, 0.05156578868627548, 0.027628358453512192, -0.052811648696660995, -0.03661591559648514, -0.028197551146149635, -0.029526174068450928, -0.03266716003417969, 0.01492056343704462, 0.007631716318428516, 0.0073196240700781345, 0.0556630976498127, -0.0006851933430880308, 0.017304174602031708, -0.051078058779239655, -0.05149288475513458, 0.0752100870013237, -0.04702159762382507, -0.006081358063966036, -0.01513044536113739, -0.04658942297101021, 0.009270218200981617, 0.07804801315069199, -0.035072386264801025, 0.06735404580831528, -0.019541772082448006, -0.03118954598903656, 0.05589374527335167, -0.05410890281200409, 0.06497151404619217, 0.02013459987938404, 0.13168059289455414, 0.0547073632478714, 0.1026046872138977, 0.02006532810628414, 0.009790940210223198, 0.0524856373667717, -0.015433426015079021, -0.08763729780912399, -0.08970648795366287, -0.010275891982018948, 0.007163363508880138, -0.0571446530520916, -0.0432867594063282, 0.06748349964618683, 0.011373750865459442, 0.053817033767700195, 0.014419110491871834, -0.0007961566443555057, -0.005729445721954107, -0.04495317116379738, -0.08812283724546432, -0.024163536727428436, -0.01837516576051712, -0.041822370141744614, -0.012529218569397926, -0.02716740593314171, -0.07603531330823898, 0.004556077998131514, -0.07108599692583084, -0.04043743014335632, -0.020581502467393875, 0.03856714814901352, -0.009753959253430367, -0.02316855639219284, -0.10894377529621124, -0.06510744988918304, -3.2243850450673656e-33, 0.011040798388421535, -0.00911091361194849, 0.0035770388785749674, 0.022240223363041878, -0.06128682568669319, 0.009768219664692879, 0.05976897478103638, -0.017396410927176476, 0.082915298640728, -0.011775647290050983, 0.1123712882399559, 0.03133105859160423, -0.06026395410299301, -0.10986768454313278, -0.03572230041027069, 0.012945620343089104, 0.011045338585972786, 0.12473142147064209, -0.06675206869840622, 0.008658594451844692, -0.06874967366456985, 0.012862223200500011, -0.007452358026057482, 0.030869031324982643, 0.04119018092751503, 0.04904066398739815, -0.0763532966375351, 0.053783487528562546, 0.06893549859523773, 0.03292422741651535, 0.002940873149782419, -0.012497149407863617, -0.011958977207541466, -0.022139810025691986, 0.0011262816842645407, -0.04205380380153656, 0.06138957291841507, 0.004214528016746044, 0.019632486626505852, -0.03166484460234642, 0.0033276749309152365, 0.014373025856912136, 0.03856915608048439, -0.004782339092344046, 0.04249067232012749, 0.021625138819217682, -0.07036581635475159, -0.047959234565496445, -0.009686633944511414, 0.029976384714245796, 0.05432639271020889, 0.057061128318309784, -0.018844325095415115, 0.0446297712624073, 0.03379589691758156, -0.03439035639166832, 0.017658039927482605, -0.06085238233208656, -0.01992751471698284, 0.015356309711933136, -0.05120911821722984, -0.06212138757109642, -0.02506256103515625, -0.018568487837910652, 0.09509925544261932, 0.03493032604455948, -0.05772824212908745, -0.0015301797538995743, 0.022138938307762146, -0.041065018624067307, 0.06637133657932281, 0.034375905990600586, -0.045758068561553955, -0.10242151468992233, 0.07918176054954529, -0.039915040135383606, 0.027247212827205658, -0.06993826478719711, -0.032742690294981, 0.002800712361931801, -0.04079087823629379, -0.014328551478683949, 0.025845583528280258, 0.02260557934641838, 0.08544616401195526, -0.010447072796523571, 0.009634963236749172, 0.06221158802509308, 0.007590538822114468, 0.005360044538974762, -0.03443257510662079, 0.025508692488074303, 0.02399480529129505, 0.07355725020170212, 0.08200227469205856, -5.127122193471223e-8, 0.03532197326421738, -0.08078432828187943, -0.006550629623234272, -0.04389498755335808, 0.033858172595500946, 0.0022023331839591265, -0.036036353558301926, 0.04938434809446335, 0.006799974013119936, -0.05539822205901146, 0.023510973900556564, 0.08086073398590088, -0.07986514270305634, 0.004684391897171736, 0.11324968934059143, -0.007906460203230381, -0.03253087028861046, 0.030800070613622665, -0.04606511443853378, -0.06582291424274445, -0.044924668967723846, 0.07343942672014236, 0.020501218736171722, 0.03444292023777962, -0.04093540832400322, -0.0037918344605714083, 0.04803553968667984, -0.006056174170225859, 0.05221084505319595, -0.020128631964325905, 0.022802092134952545, -0.015102758072316647, -0.01847640611231327, -0.056901704519987106, -0.0790344774723053, 0.0067877136170864105, -0.03721912205219269, 0.015728088095784187, 0.02896958589553833, 0.1428457647562027, 0.006113580893725157, -0.02573355659842491, -0.062369514256715775, 0.05696598440408707, 0.06755737960338593, -0.035314008593559265, 0.017184855416417122, 0.08287258446216583, -0.041118323802948, -0.06786581128835678, -0.01901482231914997, 0.09086178243160248, -0.002491553081199527, -0.05800184607505798, -0.10154523700475693, 0.024693772196769714, 0.04349347949028015, 0.017342790961265564, 0.0010847789235413074, -0.006620539352297783, 0.001072529936209321, 0.03854576498270035, 0.05615426227450371, -0.0492875762283802 ]
RBC\n,\tred\tblood\tcell.\nModified\tfrom\tWintrobe\tMM\tet\tal:\t\nClinical\thematology,\n\ted\t8,\tPhiladelphia,\t1981,\tLea\t&\tFebiger.\nMacrocytic\tanemia\n\tpresents\n\twith\tlarger-than-normal\tRBCs,\tplus\tincreased\tmean\tcorpuscular\nvolume\t(MCV)\tand\tmean\tcorpuscular\themoglobin\tconcentration\t(MCHC).\t\nMicrocytic\tanemia\n\tis
[ -0.04637422785162926, -0.105244480073452, -0.0631503313779831, 0.005935076158493757, -0.06218620017170906, 0.010088678449392319, 0.0494559071958065, 0.11516962945461273, -0.04957141727209091, 0.048620205372571945, 0.032948967069387436, -0.02546798065304756, -0.030756818130612373, 0.03043503873050213, -0.09042134881019592, -0.014605320990085602, 0.0007965034455992281, -0.0059854271821677685, -0.03728882595896721, -0.025551535189151764, -0.06416020542383194, 0.06636924296617508, 0.03612745925784111, 0.046792034059762955, 0.020759258419275284, -0.11933533102273941, -0.008070839568972588, -0.02865402214229107, -0.05664018169045448, -0.06044317036867142, -0.1128360852599144, 0.00997139886021614, 0.0324053131043911, 0.018550578504800797, 0.07014454156160355, 0.0026977835223078728, -0.045438628643751144, 0.002564483555033803, -0.017890362069010735, -0.0066650379449129105, 0.033556580543518066, -0.07856771349906921, -0.03988054767251015, 0.050366077572107315, -0.006727419327944517, 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Microcytic\tanemia\n\tis\ncharacterized\tby\tsmaller-than-normal\terythrocytes\tand\tless\tcirculating\themoglobin,\tas\tin\tiron\ndeficiency\tanemia\tand\tthalassemia.\nMost\tanemias\tare\tcaused\tby\ta\tlack\tof\tnutrients\trequired\tfor\tnormal\terythrocyte\tsynthesis,\nprincipally\tiron,\tvitamin\tB\n12\n,\tand\tfolate.\tThese\tanemias\tthat\tresult\tfrom\tan\tinadequate\tintake\tof\tiron,
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-0.06084242835640907, 0.021143430843949318, -0.02088429033756256, 0.14115989208221436, 0.10431279242038727, -0.06176827475428581, -0.005588192958384752, 0.08154036849737167, 0.030336201190948486, -0.1359548419713974, -0.017676806077361107, 0.06384294480085373, 0.011345748789608479, -0.04517222195863724, -0.05920879915356636, 0.07332206517457962, 0.10402148962020874, 0.0338311642408371, -0.02916121669113636, -0.017294542863965034, 0.11139281839132309, 0.07116764038801193, 0.095500148832798, 0.00009738521475810558 ]
have\ta\tgene\tfor\tpositive\tbalance\tand\tincreased\tstorage\tof\tiron,\tand\tapproximately\t1%\thave\tiron\noverload.\tAnemia\talso\taffects\tsome\tgroups\tmore\tthan\tothers.\tNon-Hispanic\tblacks\tand\tHispanics\nhave\tthe\thighest\tprevalence\tof\tanemia\n\tfollowed\tby\tnon-Hispanic\twhites.\tAs\tshown\tin\t\nFig.\t31.1\n,
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followed\tby\tnon-Hispanic\twhites.\tAs\tshown\tin\t\nFig.\t31.1\n,\nstages\tof\tiron\tstatus\trange\tfrom\tiron\toverload\tto\tiron\tdeficiency\tanemia\tand\tare\tsummarized\tas\nfollows\t(\nHerbert,\t1992\n):\na.\t\nStage\tI\tand\tstage\tII\tnegative\tiron\tbalance\t(i.e.,\tiron\tdepletion).\tIn\tthese\tstages\tiron\tstores
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are\tlow\tand\tthere\tis\tno\tdysfunction.\tIn\tstage\tI\tnegative\tiron\tbalance,\treduced\tiron\nabsorption\tproduces\tmoderately\tdepleted\n\tiron\tstores.\tStage\tII\tnegative\tiron\tbalance\tis\ncharacterized\tby\tseverely\tdepleted\tiron\tstores.\nb.\t\nStage\tIII\tand\tstage\tIV\tnegative\tiron\tbalance\t(i.e.,\tiron\tdeficiency).\tIron\tdeficiency\tis
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characterized\tby\tinadequate\tbody\tiron,\tpossibly\tcausing\tdysfunction\tand\tdisease.\tIn\tstage\tIII\nnegative\tiron\tbalance,\tdysfunction\tis\tnot\taccompanied\tby\tanemia;\tanemia\tdevelops\tin\tstage\nIV\tnegative\tiron\tbalance.\nc.\t\nStage\tI\tand\tstage\tII\tpositive\tiron\tbalance.\tStage\tI\tpositive\tbalance\tusually\tlasts\tfor\tseveral
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years\twith\tno\tdysfunction.\tSupplements\tof\tiron\tand/or\tvitamin\tC\tpromote\tprogression\tto\ndysfunction\tor\tdisease,\twhereas\tiron\tremoval\tprevents\tprogression\tto\tdisease.\tIron\toverload\ndisease\tdevelops\tin\tpersons\twith\tstage\tII\tpositive\tbalance\tafter\tyears\tof\tiron\toverload\thave\ncaused\tprogressive\tdamage\n\tto\ttissues\tand\torgans.\nFIG.\t31.1
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caused\tprogressive\tdamage\n\tto\ttissues\tand\torgans.\nFIG.\t31.1\nSequential\tstages\tof\tiron\tstatus.\t\nIBC\n,\tIron-binding\tcapacity;\t\nRBC\n,\tred\tblood\tcell;\t\nRE\n,\nreticuloendothelial\tcells.\n\tSource:\t(Copyright\tVictor\tHerbert,\t1995.)\nIron\tstatus\thas\ta\tvariety\tof\tindicators.\tSerum\t\nferritin\n\tis\tan\tiron\tapoferritin\tcomplex,\tone\tof\tthe
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ferritin\n\tis\tan\tiron\tapoferritin\tcomplex,\tone\tof\tthe\nchief\tstorage\tforms\tof\tiron.\tSerum\tferritin\tlevels\tare\tin\tequilibrium\twith\tbody\tiron\tstores.\tVery\tearly\n(stage\tI)\tpositive\tiron\n\tbalance\tmay\tbest\tbe\trecognized\tby\tmeasuring\t\ntotal\tiron-binding\tcapacity\n(TIBC)\n,\tthe\tcapacity\tof\ttransferrin\tto\ttake\ton\tor\tbecome\tsaturated\twith\tiron.\tConversely,
[ -0.03951261565089226, -0.07729041576385498, 0.016572993248701096, -0.04114481806755066, -0.11159930378198624, 0.021991202607750893, 0.05553857609629631, 0.008089535869657993, 0.00767305726185441, 0.04336864873766899, 0.026463711634278297, -0.009247889742255211, 0.06291594356298447, 0.028914162889122963, -0.016823306679725647, -0.018281685188412666, -0.0002350039139855653, 0.008126343600451946, -0.04515828564763069, -0.048097219318151474, 0.012006638571619987, 0.028813127428293228, 0.0001644069270696491, -0.039216745644807816, 0.04830670729279518, 0.06764744967222214, -0.06543269008398056, 0.02021896466612816, 0.09381040930747986, -0.08793015033006668, -0.13402482867240906, 0.09032593667507172, -0.04361419007182121, 0.02167954109609127, 0.007575926836580038, 0.04132358729839325, -0.05504324287176132, 0.0031490132678300142, 0.01802324503660202, 0.010369909927248955, -0.019421689212322235, -0.021218108013272285, -0.03149399906396866, 0.014412762597203255, 0.07319419085979462, -0.017324425280094147, -0.00574142299592495, -0.07502907514572144, -0.05689997971057892, -0.013428092934191227, -0.06292685866355896, -0.011766131035983562, -0.05613217502832413, 0.12285870313644409, 0.016913283616304398, 0.006270179990679026, 0.03406280279159546, -0.06293472647666931, -0.006503565236926079, -0.021829254925251007, -0.028984934091567993, -0.009200667031109333, -0.08511970192193985, 0.02296297810971737, 0.01775337941944599, 0.1036730483174324, -0.015835171565413475, 0.0187248382717371, 0.018314003944396973, 0.06918218731880188, -0.02636709436774254, 0.006299077998846769, -0.050403814762830734, 0.11472706496715546, 0.010569412261247635, 0.05717120319604874, 0.1044955626130104, -0.058419812470674515, 0.018441224470734596, -0.03291518613696098, -0.09137721359729767, 0.06437987089157104, 0.0029894632752984762, 0.049243055284023285, -0.057340107858181, 0.06921768188476562, -0.030078472569584846, 0.030379068106412888, 0.005554008763283491, 0.038450486958026886, -0.001617077854461968, -0.004065717104822397, -0.0008105090237222612, -0.020848603919148445, -0.021844539791345596, 0.003580529009923339, 0.020483942702412605, -0.018722083419561386, 0.038190651684999466, 0.013652943074703217, 0.015272041782736778, -0.0223357155919075, 0.010874321684241295, 0.01307671144604683, -0.07412724941968918, -0.04961925745010376, -0.015507531352341175, -0.06787470728158951, -0.014416508376598358, -0.02914227917790413, -0.02011222019791603, -0.01663569174706936, 0.0293265450745821, -0.08117976784706116, -0.03146783262491226, -0.07684648782014847, -0.07508259266614914, 0.04552994668483734, 0.10526659339666367, 0.029133539646863937, 0.04994884133338928, -0.009283780120313168, -0.03492458909749985, 0.09435690939426422, -0.02600552886724472, -0.08718877285718918, -0.0543464794754982, 2.131709414048293e-33, 0.08512544631958008, 0.07360056787729263, 0.004809570498764515, 0.0279170423746109, 0.031813908368349075, 0.02058393880724907, -0.039530955255031586, -0.056418489664793015, -0.02074994519352913, 0.08783286809921265, -0.09549372643232346, 0.0521635003387928, -0.04524301737546921, 0.017511364072561264, 0.0008710426045581698, -0.10718487948179245, -0.004751243162900209, 0.04695861041545868, -0.037949368357658386, -0.029477162286639214, -0.023343488574028015, 0.1810159683227539, 0.03282780945301056, -0.035391129553318024, -0.05762143433094025, -0.00976024940609932, -0.01695631630718708, -0.03384432569146156, -0.04031035304069519, 0.007986487820744514, 0.012068931944668293, -0.017721353098750114, 0.015406645834445953, 0.014416948892176151, 0.0032222194131463766, -0.06616884469985962, -0.06226138770580292, 0.001397668500430882, 0.08872383832931519, -0.0222270879894495, -0.05268775671720505, 0.0546564906835556, -0.005107745993882418, 0.06397053599357605, 0.020350301638245583, -0.04935696721076965, 0.0006663501844741404, 0.020359819754958153, 0.009485399350523949, -0.036026787012815475, 0.02092134952545166, -0.0023708289954811335, 0.06184324622154236, -0.0483442097902298, 0.026488272473216057, -0.02407263033092022, 0.027114953845739365, -0.010112294927239418, -0.02972058206796646, 0.13358953595161438, -0.0170937217772007, 0.08307751268148422, 0.06393866240978241, -0.022672515362501144, -0.0020466316491365433, 0.009672376327216625, -0.15731191635131836, -0.061057064682245255, 0.0770142525434494, -0.037802617996931076, -0.0810178890824318, 0.032918382436037064, 0.006647558882832527, 0.01489799190312624, 0.0748492032289505, -0.019607460126280785, 0.001255594426766038, -0.1003485769033432, 0.003860092954710126, -0.07177325338125229, -0.10001281648874283, -0.03979165479540825, -0.02350986935198307, -0.03247528523206711, -0.04208788648247719, -0.04395487159490585, 0.0018449847120791674, -0.09743554145097733, -0.004100355785340071, -0.04060966521501541, -0.05141811445355415, -0.01494336687028408, 0.015401830896735191, -0.06751339137554169, -0.08883542567491531, -1.9953461918811536e-33, -0.04769566282629967, -0.01191625464707613, -0.04516901075839996, 0.05312860384583473, -0.03225741907954216, -0.04252609610557556, 0.0015817080857232213, 0.006781745236366987, 0.09016527980566025, 0.026137251406908035, 0.10199827700853348, 0.05468044430017471, -0.022338058799505234, -0.11990581452846527, -0.05123879015445709, -0.018126418814063072, 0.019562765955924988, 0.04010644182562828, 0.006038871593773365, -0.010154638439416885, -0.061232227832078934, -0.005964768119156361, -0.1170506626367569, 0.022177187725901604, 0.03377702087163925, 0.02568310871720314, -0.009777761995792389, -0.00012153452553320676, 0.06273700296878815, 0.07269945740699768, 0.02386946976184845, -0.08468472212553024, 0.016895338892936707, 0.0535779669880867, 0.022090168669819832, -0.017793433740735054, 0.11980753391981125, -0.0322488434612751, -0.061512190848588943, -0.07514308393001556, 0.05180680751800537, 0.03354479372501373, 0.07454309612512589, 0.04050082340836525, 0.0023780048359185457, 0.008389100432395935, -0.09802409261465073, -0.03288660943508148, -0.04538694769144058, 0.04931912198662758, 0.0698172077536583, -0.03186970576643944, 0.01581849530339241, -0.003552118083462119, -0.0076151094399392605, 0.009943217970430851, 0.019622452557086945, -0.026639724150300026, -0.0038027972914278507, 0.04565936326980591, 0.024375069886446, -0.05696006119251251, 0.06256965547800064, -0.03208634629845619, 0.07858401536941528, -0.011559038423001766, -0.026957904919981956, -0.02892080321907997, 0.01231356430798769, -0.03721500188112259, 0.054271575063467026, 0.04635786637663841, -0.04478288069367409, -0.09937332570552826, 0.0674162283539772, -0.07297318428754807, 0.07629626244306564, -0.04919222369790077, -0.04435601830482483, -0.0003736429789569229, -0.033993199467659, 0.04247042536735535, 0.0017611220246180892, 0.03411727398633957, 0.0005893214838579297, 0.04116498678922653, -0.004561328794807196, 0.04134377837181091, 0.041337836533784866, 0.05362851917743683, 0.01644670031964779, 0.06570282578468323, 0.0733753964304924, 0.0683484748005867, 0.08019185811281204, -4.519960938864642e-8, -0.04255308583378792, -0.02564208395779133, -0.003888891777023673, -0.0360906608402729, 0.05121658742427826, -0.041079211980104446, 0.10548556596040726, -0.008752516470849514, -0.009742981754243374, -0.05635750666260719, 0.08763755857944489, 0.04372439160943031, -0.06295058131217957, -0.08807171881198883, 0.0811142548918724, 0.06599228084087372, -0.004742092452943325, 0.05951523780822754, -0.02289954572916031, -0.04280826076865196, 0.007497336249798536, 0.0742686539888382, 0.00717054633423686, -0.002857626648619771, -0.05611207336187363, -0.030081050470471382, -0.062203191220760345, 0.006700009573251009, 0.012124661356210709, 0.0397496297955513, 0.02125769481062889, -0.055044155567884445, 0.05920989438891411, -0.06886248290538788, -0.006069280207157135, 0.033162638545036316, -0.033666644245386124, -0.018175996840000153, 0.017861945554614067, 0.1388290673494339, 0.01050910446792841, 0.020560238510370255, -0.010247885249555111, 0.08035652339458466, 0.07321789115667343, -0.04200024902820587, -0.04272051155567169, 0.0659068152308464, 0.021427500993013382, -0.04827984794974327, -0.0007012727437540889, 0.10911537706851959, -0.013560711406171322, -0.060478996485471725, -0.04333969205617905, 0.05198210850358009, 0.007492564618587494, 0.06017167121171951, -0.002488195663318038, 0.03734617307782173, 0.008513309061527252, 0.055934347212314606, 0.061405036598443985, -0.014983613975346088 ]
measurement\tof\tserum\tor\tplasma\tferritin\tlevels\tmay\tbest\treveal\tearly\t(stages\tI\tor\tII)\tnegative\tiron\nbalance,\talthough\tserum\tTIBC\tmay\tbe\tas\tgood\tan\tindicator\t(see\t\nChapter\t5\n).\t\nTransferrin\tsaturation\nis\tthe\tmeasure\tof\tthe\tamount\tof\tiron\n\tbound\tto\ttransferrin\tand\tis\ta\tgauge\tof\tiron\tsupply\tto\tthe\ttissues;
[ -0.010138342157006264, -0.06466903537511826, 0.04906264320015907, -0.03566389158368111, -0.12384707480669022, -0.008077774196863174, 0.06644361466169357, 0.004908639006316662, 0.018010703846812248, 0.06791645288467407, 0.08595200628042221, -0.019384095445275307, 0.03641655296087265, 0.04776579886674881, -0.02219104766845703, 0.0151063846424222, -0.03218371421098709, 0.03752056881785393, -0.04569433256983757, -0.0681697279214859, 0.05538398027420044, 0.07146118581295013, 0.014112423174083233, -0.016864802688360214, 0.0692887082695961, 0.030807215720415115, -0.08617372065782547, 0.003066633129492402, 0.037266992032527924, -0.05239750072360039, -0.13354279100894928, 0.051613349467515945, -0.08307071775197983, 0.017553793266415596, 0.024913853034377098, 0.044831741601228714, -0.06111953407526016, 0.025885801762342453, 0.07325777411460876, 0.031786855310201645, 0.013546014204621315, -0.06127333268523216, -0.05544536933302879, 0.01820199191570282, 0.09075218439102173, 0.02980155311524868, 0.02545388787984848, -0.049140822142362595, -0.047307126224040985, -0.004869643598794937, -0.02365492470562458, 0.0036304029636085033, -0.06389430910348892, 0.0757000744342804, 0.0003469069779384881, 0.04446122795343399, 0.015933355316519737, -0.053776368498802185, 0.002213959814980626, -0.02512524276971817, -0.031129753217101097, -0.014313767664134502, -0.0884743258357048, 0.01939070038497448, 0.019414957612752914, 0.061017196625471115, -0.0038431347347795963, 0.014005404897034168, -0.005662813317030668, 0.08941738307476044, -0.03384530916810036, 0.013815492391586304, -0.011289618909358978, 0.08943890780210495, -0.047874271869659424, 0.006787718273699284, 0.09811537712812424, -0.046082474291324615, -0.0005776322213932872, -0.008201590739190578, -0.07105550169944763, 0.10039744526147842, 0.01263393647968769, 0.011587853543460369, -0.06346090137958527, 0.04131648689508438, -0.00875808671116829, 0.018209308385849, 0.016024818643927574, 0.00299924798309803, -0.007253711577504873, -0.025177406147122383, -0.07751043140888214, -0.022422540932893753, -0.0019264447037130594, -0.019018666818737984, -0.020949168130755424, -0.008409224450588226, 0.015776829794049263, 0.005072635132819414, 0.023132968693971634, -0.04831735044717789, 0.004452442284673452, 0.03980225324630737, -0.05864543840289116, -0.05318254232406616, -0.02129105105996132, -0.057963281869888306, 0.0476636067032814, -0.00343066593632102, -0.01907765306532383, -0.017459053546190262, 0.06755095720291138, -0.07849680632352829, -0.001771394396200776, -0.06960201263427734, -0.0951157659292221, 0.0484621599316597, 0.14002934098243713, 0.04659121483564377, 0.05044696852564812, -0.0076675196178257465, -0.01341355498880148, 0.07372336089611053, -0.05796903744339943, -0.01870637573301792, 0.0040363045409321785, 1.590963461899817e-33, 0.06497185677289963, 0.07134465873241425, 0.021107910200953484, 0.05069209262728691, -0.005862667225301266, 0.024419358000159264, -0.04443737491965294, -0.0680118203163147, -0.027504250407218933, 0.07311287522315979, -0.1187136098742485, 0.03629156947135925, -0.05249978229403496, 0.04869246482849121, -0.005196109879761934, -0.08390559256076813, -0.010144021362066269, 0.09045983105897903, -0.011352377012372017, -0.04939330369234085, -0.0444910004734993, 0.1695641577243805, 0.035867661237716675, -0.023212578147649765, -0.05969211831688881, -0.017421327531337738, 0.0063005308620631695, -0.04239586368203163, -0.053592294454574585, 0.026441149413585663, 0.029051700606942177, -0.012379844672977924, 0.014012206345796585, -0.007839590311050415, 0.02132352814078331, -0.03678100183606148, -0.011564098298549652, 0.048816170543432236, 0.03850410133600235, -0.02788279950618744, -0.05707823857665062, 0.03389069810509682, 0.024962231516838074, 0.056591782718896866, 0.01126385573297739, -0.0000659762226860039, -0.0005763514782302082, 0.0014946062583476305, 0.03274707868695259, -0.07228466123342514, 0.013101172633469105, -0.03608927130699158, 0.07829920947551727, -0.055693574249744415, 0.06254894286394119, 0.006205526180565357, 0.015964780002832413, 0.010557664558291435, -0.0417344905436039, 0.08156988024711609, -0.03211722522974014, 0.03603704646229744, 0.042017288506031036, -0.05165509134531021, 0.013988223858177662, 0.010417552664875984, -0.15105241537094116, -0.053473182022571564, 0.07444240152835846, -0.050616152584552765, -0.11369191855192184, 0.03272769972681999, -0.01893291436135769, 0.026859819889068604, 0.07043743133544922, -0.0038540924433618784, 0.06188251078128815, -0.037132628262043, 0.0023148239124566317, -0.04971151798963547, -0.10476084798574448, -0.037913933396339417, -0.01753051020205021, -0.04357131943106651, -0.019659023731946945, -0.035638563334941864, 0.02442076802253723, -0.0845353901386261, -0.023038722574710846, -0.04495299234986305, -0.06313470751047134, 0.0379851795732975, 0.007071683183312416, -0.06190735474228859, -0.11168456077575684, -2.1375828450405736e-33, -0.07094164937734604, 0.003563319332897663, -0.05026903748512268, 0.0579705573618412, -0.01744679920375347, -0.027417751029133797, -0.008356597274541855, 0.06879565119743347, 0.05275558680295944, -0.0025666202418506145, 0.09805213660001755, 0.028562160208821297, -0.09031716734170914, -0.11213874071836472, -0.04843820258975029, -0.05827224254608154, 0.04885005205869675, 0.054426442831754684, -0.027767490595579147, -0.009283876046538353, -0.04639074206352234, 0.012466478161513805, -0.09985969215631485, -0.00902530550956726, 0.01923089101910591, 0.046131644397974014, -0.002562033711001277, -0.02926555834710598, 0.05492105334997177, 0.05816751345992088, 0.03541344031691551, -0.09030932933092117, 0.0108390087261796, 0.09934616088867188, -0.011634552851319313, 0.0317525751888752, 0.0749741941690445, -0.0511627271771431, -0.09421194344758987, -0.025512700900435448, 0.04097527265548706, 0.017270898446440697, 0.10604175180196762, 0.006613657809793949, -0.013159215450286865, -0.01448907982558012, -0.07720810174942017, -0.06541217863559723, -0.07828733325004578, 0.039136987179517746, 0.07320109754800797, -0.015076877549290657, -0.027227234095335007, -0.02080109342932701, 0.006732834968715906, -0.04040421172976494, -0.007328197825700045, -0.08895992487668991, -0.038127824664115906, 0.016389671713113785, 0.023281389847397804, -0.057340946048498154, 0.06151358410716057, -0.006974678486585617, 0.04786688834428787, -0.01845678500831127, -0.034882910549640656, -0.031337060034275055, -0.02597244828939438, -0.007139074150472879, 0.010373533703386784, 0.03442474827170372, -0.07324222475290298, -0.11998102813959122, 0.07287144660949707, -0.08423369377851486, 0.045501112937927246, -0.02020188979804516, -0.045293670147657394, -0.02573120966553688, -0.051132358610630035, 0.006076359190046787, 0.009617813862860203, 0.019719654694199562, 0.015551364980638027, -0.005758053623139858, 0.018588120117783546, 0.029546892270445824, 0.06414063274860382, 0.08887060731649399, 0.012638718821108341, 0.04188769310712814, 0.040182843804359436, 0.07195337116718292, 0.0690375566482544, -4.81050470568789e-8, -0.03091633878648281, 0.020640403032302856, -0.003798950230702758, -0.05811639875173569, 0.0373186357319355, -0.015018693171441555, 0.09092708677053452, 0.03389821946620941, -0.013619733974337578, -0.0555998720228672, 0.07767771929502487, 0.043850142508745193, -0.05334782227873802, -0.0621783509850502, 0.08299649506807327, 0.023007623851299286, -0.005788747221231461, 0.07442115992307663, -0.0005560991703532636, -0.08000010251998901, -0.005732407793402672, 0.0853932574391365, -0.007089318707585335, -0.02197754569351673, -0.026465540751814842, -0.016638383269309998, -0.07464981824159622, 0.00029363069916144013, -0.000601047242525965, 0.03238895907998085, 0.057715900242328644, -0.03275814279913902, 0.025744549930095673, -0.039866626262664795, -0.02912072092294693, 0.07937611639499664, -0.0384175181388855, -0.002406076993793249, -0.0016459194011986256, 0.15069879591464996, -0.039463575929403305, 0.0045079453848302364, 0.0168322641402483, 0.07834817469120026, 0.06655163317918777, -0.03683127090334892, -0.011669928207993507, 0.07325949519872665, -0.0071729752235114574, -0.07233047485351562, 0.0026951555628329515, 0.11357678472995758, -0.021831346675753593, -0.05528751015663147, -0.03749615699052811, 0.04359719902276993, 0.07142726331949234, 0.03169886767864227, -0.03203435242176056, 0.020634116604924202, 0.03553491830825806, 0.05645741894841194, 0.023052068427205086, -0.014035026542842388 ]
bound\tto\ttransferrin\tand\tis\ta\tgauge\tof\tiron\tsupply\tto\tthe\ttissues;\nthe\tpercent\tsaturation\t=\tserum\tiron/TIBC\t×\t100.\nIron\tdeficiency\tanemia\nPathophysiology\nIron\tdeficiency\tanemia\n\tis\tcharacterized\tby\tthe\tproduction\tof\tmicrocytic\terythrocytes\tand\ta
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-0.08089751750230789, -0.03653819113969803, -0.04392130300402641, 0.08426634222269058, 0.11168673634529114, -0.04710705950856209, 0.02259686030447483, 0.05875624716281891, 0.0017735690344125032, -0.10573505610227585, -0.029583046212792397, 0.045639123767614365, 0.002229644451290369, -0.061095647513866425, -0.07401592284440994, 0.05648685619235039, 0.0633787140250206, 0.013884066604077816, 0.0062796552665531635, 0.00017356830358039588, 0.020528532564640045, 0.12700043618679047, 0.056728191673755646, -0.06631460785865784 ]
diminished\tlevel\tof\tcirculating\themoglobin.\tThis\tmicrocytic\tanemia\tis\tthe\tlast\tstage\tof\tiron\ndeficiency,\tand\tit\trepresents\tthe\tend\tpoint\tof\ta\tlong\n\tperiod\tof\tiron\tdeprivation.\tThere\tare\tmany\ncauses\tof\tiron\tdeficiency\tanemia\tas\tdiscussed\tin\t\nBox\t31.1\n.\nBOX\t31.1\nCauses\tof\tIron\tDeficiency\tAnemia\nInadeq\nuate\nInge\nstion
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.\nBOX\t31.1\nCauses\tof\tIron\tDeficiency\tAnemia\nInadeq\nuate\nInge\nstion\nPoor\tdiet\twithout\tsupplementation\tof\tiron\nInadeq\nuate\nAbso\nrptio\nn\nDiarrhea,\tachlorhydria,\tintestinal\tdisease\tsuch\tas\tceliac\tdisease,\tatrophic\tgastritis,\tpartial\tor\ntotal\tgastrectomy,\tor\tdrug\tinterference\nInadeq\nuate\nUtili\nzatio\nn\nChronic\tgastrointestinal\tdisturbances\nIncreas\ned\nReq
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Utili\nzatio\nn\nChronic\tgastrointestinal\tdisturbances\nIncreas\ned\nReq\nuire\nment\nIncrease\tof\tblood\tvolume,\twhich\toccurs\tduring\tinfancy,\tadolescence,\tpregnancy,\tand\tlactation\nand\twhich\tis\tnot\tbeing\tmatched\twith\tintake\nIncreas\ned\nExcr\netion\nExcessive\tmenstrual\tblood\t(in\tfemales);\themorrhage\tfrom\tinjury;\tor\tchronic\tblood\tloss\tfrom\ta
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bleeding\tulcer,\tbleeding\themorrhoids,\tesophageal\tvarices,\tregional\tenteritis,\tceliac\n\tdisease,\nCrohn’s\tdisease,\tulcerative\tcolitis,\tparasitic\tor\tmalignant\tdisease\nIncreas\ned\nDest\nructi\non\nCaused\tby\ta\tchronic\tinflammation\tor\tother\tchronic\tdisorder\tleading\tto\tdestruction\tof\tRBC’s
[ -0.003182373009622097, -0.09911733865737915, 0.03877750411629677, -0.01725705899298191, -0.10932528227567673, 0.035645559430122375, 0.010583148337900639, 0.028139809146523476, 0.034614186733961105, 0.07131300866603851, 0.06284838169813156, -0.024344436824321747, -0.016257766634225845, 0.06462376564741135, -0.09643378108739853, -0.07370828837156296, -0.035527199506759644, 0.007960604503750801, -0.00700942799448967, -0.014690699987113476, -0.0019038459286093712, 0.08856334537267685, 0.06040096655488014, -0.03404589369893074, 0.042912255972623825, -0.022160472348332405, -0.02928035706281662, -0.001689970726147294, 0.027850016951560974, -0.017056113108992577, -0.08172081410884857, -0.032913126051425934, -0.026064075529575348, -0.028721071779727936, 0.11680210381746292, -0.03651462495326996, -0.060336098074913025, -0.015416896902024746, 0.07135976850986481, 0.021582581102848053, 0.07562867552042007, -0.04890279471874237, -0.05035964027047157, 0.013757564127445221, 0.03722373768687248, 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0.03344496339559555, -0.07849033176898956, -0.002999198157340288, 0.03910399228334427, 0.07458892464637756, -0.012763152830302715, 0.02528396062552929, 0.06515469402074814, 0.02193562313914299, -0.07483939826488495, -0.02885439060628414, 0.06736954301595688, -0.03251459822058678, -0.004991327878087759, 0.026292989030480385, 0.017319904640316963, 0.12328853458166122, 0.05500277504324913, -0.006619676016271114, 0.0023871141020208597, 0.00877698790282011, 0.12160226702690125, 0.13245809078216553, 0.002010818338021636 ]
A\tcommon\tcause\tof\tiron\tdeficiency\tis\tblood\tloss,\teither\tchronic\tor\tacute,\tincluding\theavy\tmenstrual\nbleeding\tin\twomen.\tIt\tcan\talso\tbe\tcaused\tby\tmalabsorption,\tmedications,\tand\tinadequate\tintake.\nBecause\tanemia\tis\tthe\tlast\tmanifestation\tof\tchronic,\tlong-term\tiron\tdeficiency,\tthe\tsymptoms\treflect
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a\tmalfunction\tof\ta\tvariety\tof\tbody\tsystems.\tInadequate\tmuscle\tfunction\tis\treflected\tin\tdecreased\nwork\tperformance\tand\texercise\ttolerance.\tNeurologic\tinvolvement\tis\tmanifested\tby\tbehavioral\nchanges\tsuch\tas\tfatigue,\tanorexia,\tand\t\npica\n\t(consumption\tof\tnonfood\titems),\tespecially\t\npagophagia\n(ice\teating).
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(consumption\tof\tnonfood\titems),\tespecially\t\npagophagia\n(ice\teating).\n\tAbnormal\tcognitive\tdevelopment\tin\tchildren\tmay\tindicate\tiron\tdeficiency\tbefore\tit\thas\ndeveloped\tinto\tovert\tanemia\t(\nJáuregui-Lobera,\t2014\n).\nGrowth\tabnormalities,\tepithelial\tdisorders,\tand\ta\treduction\tin\tgastric\tacidity\tare\talso\tcommon.\tA
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possible\tsign\tof\tearly\tiron\tdeficiency\tis\treduced\timmunocompetence,\tparticularly\tdefects\tin\tcell-\nmediated\timmunity\tand\tthe\tphagocytic\tactivity\tof\tneutrophils,\n\twhich\tmay\tlead\tto\tfrequent\tinfections.\nRestless\tlegs\tsyndrome\t(RLS)\n\twith\tleg\tpain\tor\tdiscomfort\tmay\tresult\tfrom\ta\tlack\tof\tiron\tin\tthe\nbrain;\tthis\talters\tdopamine\tproduction\tand\tmovement\t(
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brain;\tthis\talters\tdopamine\tproduction\tand\tmovement\t(\nConnor\tet\tal,\t2017\n).\nAs\tiron\tdeficiency\tanemia\tbecomes\tmore\tsevere,\tdefects\tarise\tin\tthe\tstructure\tand\tfunction\tof\tthe\nepithelial\ttissues,\tespecially\tof\tthe\ttongue,\tnails,\tmouth,\tand\tstomach.\tThe\tskin\tmay\tappear\n\tpale\tin
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0.04259588196873665, 0.026022080332040787, 0.039780035614967346, 0.10305269062519073, -4.4509377516988025e-8, 0.03424093499779701, -0.017239749431610107, 0.0034419854637235403, -0.013027245178818703, 0.030247997492551804, -0.031467825174331665, 0.09719060361385345, -0.015950169414281845, 0.009514310397207737, -0.06448391079902649, 0.006332580000162125, 0.08366001397371292, -0.06805501133203506, -0.028800874948501587, 0.08358123153448105, 0.04380802810192108, 0.04294377937912941, 0.0682908371090889, -0.013389083556830883, -0.043104175478219986, -0.043929968029260635, 0.07600349187850952, -0.0347064808011055, -0.012287960387766361, -0.06416790187358856, 0.027693498879671097, -0.01669059693813324, 0.006507250480353832, 0.020051220431923866, 0.02146773412823677, 0.046005088835954666, -0.011967175640165806, -0.017783476039767265, -0.04742972552776337, -0.013722214847803116, 0.06241944804787636, -0.0837424024939537, -0.03615852817893028, 0.00569192785769701, 0.12014162540435791, 0.014545700512826443, 0.011716286651790142, -0.022214476019144058, 0.06776642054319382, 0.08773108571767807, -0.08425671607255936, 0.03513028845191002, 0.03822796791791916, 0.001954245613887906, -0.07423398643732071, -0.011168497614562511, 0.10649170726537704, -0.024723267182707787, -0.017067359760403633, -0.05133368447422981, 0.027097122743725777, 0.06675511598587036, 0.07165393978357315, -0.04222284257411957, -0.008335214108228683, 0.09648706763982773, 0.03318333625793457, 0.07614154368638992, -0.011012956500053406 ]
,\ta\tcompletely\tsmooth,\twaxy,\tand\tglistening\tappearance\tof\tthe\ttongue.\nAngular\tstomatitis\tand\ta\tform\tof\tdysphagia\tmay\toccur.\tGastritis\toccurs\tfrequently\tand\tmay\n\tresult\tin\nachlorhydria\t(low\tstomach\tacid).\tFingernails\tcan\tbecome\tthin\tand\tflat,\tand\teventually\t\nkoilonychia\n(spoon-shaped\tnails)\tmay\tbe\tnoted\t(\nFig.\t31.2\n).
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-0.03256809711456299, -0.014218676835298538, 0.025089560076594353, 0.03272564336657524, 0.025474343448877335, -0.07344891130924225, 0.00905601866543293, 0.09475674480199814, 0.03171347454190254, -0.09311234951019287, -0.026946155354380608, 0.11218062043190002, 0.01629980467259884, 0.01168136391788721, -0.05868002027273178, 0.03720416873693466, 0.11136416345834732, 0.044658444821834564, 0.01789247803390026, 0.02999509684741497, 0.029932593926787376, 0.08027040958404541, 0.05906632915139198, 0.016998644918203354 ]
FIG.\t31.2\nFingernails\twith\tcup-like\tdepressions\t(koilonychia)\tare\ta\tsign\tof\tiron\tdeficiency\tin\tadults.\n\tSource:\t(From\nHeitz\tC.\tKoilonychia.\tIn:\tFlickr\t[website].\t\t\nhttps://www.flickr.com/photos/coreyheitzmd/15023020192\n.\tApril\t14,\t2014.)\nProgressive,\tuntreated\tanemia\tresults\tin\tcardiovascular\tand\trespiratory\tchanges\tthat\tcan
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eventually\tlead\tto\tcardiac\tfailure.\tSome\tsocial\tand\temotional\tbehavioral\n\tsymptoms\trespond\tto\tiron\ntherapy\tbefore\tthe\tanemia\tis\tcured,\tsuggesting\tthey\tmay\tbe\tthe\tresult\tof\ttissue\tdepletion\tof\tiron-\ncontaining\tenzymes\trather\tthan\ta\tdecreased\tlevel\tof\themoglobin\t(\nsee\n\t\nPathophysiology\tand\tCare\nManagement\tAlgorithm:\n\tIron\tDeficiency\tAnemia\n).
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Management\tAlgorithm:\n\tIron\tDeficiency\tAnemia\n).\nAssessment\nA\tdefinitive\tdiagnosis\tof\tiron\tdeficiency\tanemia\trequires\tmore\tthan\tone\tmethod\tof\tiron\tevaluation;\nserum\tferritin,\tiron,\tand\ttransferrin\tare\tthe\tmost\tuseful.\tThe\tevaluation\talso\tshould\tinclude\tan
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assessment\tof\tcell\tsize\tand\tshape\t(morphology).\tBy\titself,\themoglobin\tconcentration\tis\tunsuitable\tas\na\tdiagnostic\ttool\tin\tcases\tof\tsuspected\tiron\tdeficiency\tanemia\tfor\tthree\treasons:\n\t(1)\tit\tis\taffected\tonly\nlate\tin\tthe\tdisease,\t(2)\tit\tcannot\tdistinguish\tiron\tdeficiency\tfrom\tother\tanemias,\tand\t(3)\themoglobin
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-0.02211170457303524, -0.009528244845569134, 0.02142941765487194, 0.06861807405948639, 0.09887292981147766, -4.799390396215131e-8, 0.043135158717632294, -0.03791040554642677, -0.04393266886472702, -0.016119714826345444, 0.005115534644573927, -0.018799543380737305, -0.01883089728653431, 0.032676126807928085, -0.003068546997383237, -0.014869987964630127, 0.029475919902324677, 0.0793456956744194, -0.04922206699848175, -0.06236101686954498, 0.11752552539110184, 0.022689996287226677, 0.002242079935967922, 0.09621010720729828, -0.03126421943306923, -0.0648309588432312, 0.004424592945724726, 0.020294634625315666, 0.009735147468745708, 0.019505029544234276, -0.009642701596021652, 0.0020063435658812523, -0.010712077841162682, -0.03958822041749954, 0.020416151732206345, 0.022381071001291275, 0.026567324995994568, -0.0174774881452322, 0.017859285697340965, -0.029543034732341766, -0.027639051899313927, 0.04073218256235123, -0.040531791746616364, 0.023244047537446022, 0.02459327131509781, 0.12288188934326172, -0.04698900878429413, -0.048604026436805725, -0.06852075457572937, 0.0844585970044136, 0.10534539818763733, -0.07185228914022446, -0.027697481215000153, 0.0856616422533989, 0.009415403939783573, -0.10119010508060455, -0.02988602966070175, 0.0814819261431694, -0.018426788970828056, -0.012542306445538998, -0.04718689247965813, 0.06656380742788315, 0.08993654698133469, 0.03334607556462288, -0.03141608089208603, 0.012195577844977379, 0.07512836158275604, 0.12771989405155182, 0.06885524839162827, -0.06520524621009827 ]
values\tmay\tbe\twithin\tthe\tnormal\trange\tdespite\tiron\tdeficiency.\nAfter\tabsorption,\tiron\tis\ttransported\tby\tplasma\t\ntransferrin\n—a\tbeta-1\tglobulin\t(protein)\tthat\tbinds\niron\tderived\tfrom\tthe\tgastrointestinal\ttract,\tiron\tstorage\tsites,\tor\themoglobin\tbreakdown—to\tthe\nbone\tmarrow
[ -0.011007598601281643, -0.0756826102733612, -0.057674795389175415, -0.04748939350247383, -0.08953329920768738, -0.015116543509066105, 0.0758494958281517, 0.09328483045101166, -0.016382474452257156, 0.03344787284731865, 0.08648370951414108, 0.009849601425230503, 0.019190195947885513, 0.06925134360790253, -0.09463278949260712, -0.006402835249900818, -0.0721246749162674, 0.0259831752628088, -0.07690470665693283, -0.05694180354475975, -0.022281482815742493, 0.1106129139661789, -0.008900370448827744, 0.019967451691627502, 0.051184386014938354, -0.022288605570793152, -0.004961669910699129, 0.0026870269794017076, 0.016416670754551888, -0.04859321191906929, -0.11797390878200531, 0.006417327094823122, 0.012156853452324867, 0.012703520245850086, 0.046316590160131454, 0.03783164173364639, -0.04394467920064926, -0.031346142292022705, 0.013563250191509724, 0.0026101290713995695, 0.09402118623256683, -0.10768023133277893, -0.03427879884839058, -0.0021853437647223473, 0.05744947865605354, 0.013759307563304901, -0.055035632103681564, -0.015132546424865723, -0.007370529696345329, 0.07148969173431396, -0.04309981316328049, -0.012828054837882519, -0.06655822694301605, 0.10858882963657379, 0.03954271227121353, -0.03325364738702774, -0.08498897403478622, -0.08600854873657227, 0.001050375634804368, -0.00979151763021946, -0.06388335675001144, 0.0035666576586663723, -0.008430535905063152, 0.028849801048636436, 0.11356144398450851, 0.021598665043711662, 0.0016126123955473304, -0.020218944177031517, 0.004500850103795528, 0.0625634640455246, -0.045097716152668, -0.019839895889163017, -0.06251948326826096, 0.11905553936958313, -0.03377881646156311, 0.024770131334662437, 0.020046602934598923, -0.039611656218767166, 0.02874171733856201, 0.005355450790375471, -0.061354923993349075, 0.06000809371471405, 0.0367184616625309, 0.12067200988531113, -0.03273990377783775, 0.04675617441534996, -0.048507869243621826, 0.10678717494010925, -0.025086766108870506, 0.020387589931488037, 0.029153889045119286, -0.03948571905493736, 0.027385463938117027, -0.030863236635923386, -0.012556079775094986, -0.027519673109054565, 0.007703537121415138, -0.06823631376028061, -0.0023113226052373648, -0.03374535217881203, -0.051368359476327896, 0.00043114201980642974, 0.004186857491731644, -0.002195378066971898, -0.07423946261405945, -0.030934497714042664, 0.00589757738634944, -0.014139417558908463, 0.02565884403884411, 0.019271928817033768, 0.014223978854715824, 0.027713965624570847, 0.07212832570075989, -0.04451357573270798, 0.0012633188161998987, 0.01086598914116621, -0.054004229605197906, -0.005608798936009407, 0.09321621805429459, 0.011573854833841324, -0.0248885378241539, -0.0576733835041523, 0.005279171280562878, 0.07419930398464203, -0.040068093687295914, -0.02915622852742672, -0.02186289057135582, 2.9361200347831545e-33, 0.04076221585273743, -0.027072440832853317, 0.049745652824640274, 0.050803668797016144, 0.0010172637412324548, 0.016054581850767136, -0.07223037630319595, -0.09104135632514954, 0.010468102060258389, 0.08429958671331406, -0.1179034486413002, -0.015891144052147865, 0.029596472159028053, 0.07877270877361298, -0.006648321636021137, -0.03709305450320244, -0.015823865309357643, 0.03121575154364109, -0.0025630590971559286, 0.011372264474630356, 0.018457282334566116, 0.1605086326599121, 0.039460450410842896, -0.022286655381321907, 0.01956276223063469, 0.03086329810321331, -0.11413447558879852, -0.002593117766082287, 0.02673404850065708, 0.013568605296313763, -0.029178479686379433, -0.04680193215608597, -0.05465622991323471, -0.015552239492535591, 0.03474598750472069, -0.03760882467031479, 0.01420436892658472, 0.027846764773130417, 0.03066099062561989, 0.021263305097818375, 0.0241638645529747, -0.03428246080875397, -0.05317136272788048, -0.0024946732446551323, 0.08552702516317368, -0.07823798060417175, -0.009065622463822365, 0.00883304513990879, -0.010612811893224716, 0.013764064759016037, 0.04038344323635101, -0.030020447447896004, 0.09202515333890915, -0.10060140490531921, -0.06029970198869705, -0.02833406999707222, -0.025998422876000404, 0.04919867217540741, -0.021184559911489487, 0.1678922027349472, -0.028404682874679565, 0.06626226007938385, 0.04520806297659874, -0.0270990002900362, 0.0023327646777033806, 0.04149230569601059, -0.1896892637014389, -0.10366553068161011, 0.01651732623577118, 0.02878819778561592, -0.06071518734097481, -0.0349561981856823, 0.020468048751354218, 0.020717032253742218, 0.02058720961213112, 0.014585920609533787, -0.02330319583415985, 0.0005510637420229614, -0.030486518517136574, -0.061553698033094406, -0.038561102002859116, -0.04118810221552849, -0.05122426524758339, 0.04291287064552307, -0.03478002920746803, -0.028745604678988457, 0.03944261372089386, -0.11033560335636139, 0.005637116730213165, -0.028277378529310226, 0.0019887483213096857, 0.03458213806152344, -0.09034670144319534, -0.0678744986653328, -0.08007914572954178, -4.691676032014116e-33, -0.013705316931009293, 0.0002227783261332661, -0.024574149399995804, 0.012508579529821873, -0.030526936054229736, 0.00022080143389757723, 0.0703480988740921, -0.020554957911372185, 0.13389606773853302, 0.016171894967556, 0.10253112763166428, 0.026845594868063927, -0.10588286072015762, -0.14045071601867676, 0.0021400866098701954, 0.06754010915756226, -0.04176774621009827, 0.045506931841373444, -0.02244950830936432, -0.014795681461691856, -0.13020268082618713, 0.03079347312450409, -0.027164900675415993, 0.04663233086466789, 0.02810744196176529, 0.10204031318426132, 0.00980094913393259, 0.006413422990590334, 0.06171420216560364, 0.005988887511193752, -0.051854170858860016, -0.04142938181757927, -0.013459928333759308, 0.02443610318005085, -0.006261137779802084, -0.01896035671234131, 0.04352955520153046, -0.05760518088936806, -0.02075691893696785, -0.030146513134241104, 0.019040890038013458, 0.06286568939685822, 0.05053333565592766, 0.0513242706656456, 0.031957048922777176, 0.01123860850930214, -0.03608812764286995, -0.04810119420289993, -0.022796984761953354, -0.005659686401486397, 0.10322757810354233, -0.020934034138917923, 0.02941029705107212, 0.013279860839247704, -0.0134971272200346, 0.014043851755559444, 0.03181388974189758, -0.0201191995292902, -0.032554496079683304, -0.03598945960402489, -0.0468270517885685, -0.0596943162381649, 0.026636239141225815, 0.039128538221120834, 0.04255250468850136, -0.02617780864238739, -0.014933465979993343, -0.060234807431697845, -0.010439070872962475, -0.055196747183799744, 0.041309479624032974, -0.010966295376420021, 0.03591202571988106, -0.09633811563253403, 0.08976571261882782, -0.06054014712572098, -0.023533180356025696, -0.038026630878448486, 0.020688878372311592, -0.030580412596464157, -0.08088954538106918, 0.027184391394257545, 0.02103523537516594, 0.0024686723481863737, 0.013306795619428158, 0.0031237006187438965, -0.02929355762898922, 0.07099372148513794, 0.03222743794322014, 0.04567553475499153, 0.0038046541158109903, 0.029284359887242317, -0.017092805355787277, 0.11494152992963791, 0.09874509274959564, -4.897356120636687e-8, 0.0531933456659317, -0.05584477633237839, -0.01938617043197155, -0.019081013277173042, 0.02888965606689453, 0.019166870042681694, -0.010279529727995396, 0.03949471563100815, 0.03690163418650627, -0.02814401499927044, 0.047904305160045624, 0.09536261856555939, -0.08432503789663315, -0.06649083644151688, 0.0631130263209343, 0.06969917565584183, -0.06916648894548416, 0.001750742900185287, -0.017051568254828453, -0.06657956540584564, -0.025689931586384773, 0.03955862671136856, -0.035047806799411774, 0.016435982659459114, 0.01480898354202509, -0.028439857065677643, -0.05912308394908905, 0.0450177900493145, 0.01723828911781311, -0.003981276880949736, 0.053141627460718155, -0.031017379835247993, 0.016739577054977417, -0.039873600006103516, -0.009641519747674465, 0.01828109659254551, 0.01746874488890171, -0.005109153687953949, -0.012775887735188007, 0.0845993384718895, -0.052644286304712296, -0.022578541189432144, -0.06867163628339767, 0.02798098884522915, 0.028607646003365517, -0.017923617735505104, -0.0526568628847599, 0.1292370706796646, 0.0003918840957339853, -0.07083068042993546, 0.010782046243548393, 0.03369293361902237, -0.012276791036128998, -0.03065606765449047, -0.0940202847123146, 0.013382420875132084, 0.005526005756109953, -0.020478395745158195, 0.01841994933784008, -0.0005766339018009603, 0.0153876431286335, 0.07702355831861496, 0.0709076002240181, -0.04411756992340088 ]
bone\tmarrow\n\t(hemoglobin\tsynthesis),\tendothelial\tcells\t(storage),\tor\tplacenta\t(fetal\tneeds).
[ -0.05142210051417351, -0.04295085370540619, -0.008481576107442379, -0.016507074236869812, -0.059157293289899826, -0.006601984612643719, 0.04077274352312088, 0.04064379632472992, -0.035966046154499054, 0.07836927473545074, 0.04055366665124893, -0.034404002130031586, -0.04664355516433716, -0.0022890630643814802, -0.0915091335773468, -0.02397095039486885, -0.049072131514549255, 0.028882302343845367, -0.04601811245083809, 0.033192504197359085, 0.005856705363839865, 0.07659310847520828, 0.01827872171998024, 0.0064218416810035706, 0.04654912278056145, -0.06408936530351639, -0.015561343170702457, 0.021635504439473152, -0.01119961403310299, -0.02135840244591236, -0.11670549213886261, -0.01680758222937584, 0.021113991737365723, -0.03533016890287399, 0.017664916813373566, -0.02556639164686203, 0.051036953926086426, -0.047167886048555374, -0.057228971272706985, 0.02649063803255558, 0.039488133043050766, -0.08801485598087311, -0.061291828751564026, 0.06365250796079636, 0.09067735075950623, 0.04953235387802124, 0.041047148406505585, -0.0053362431935966015, -0.07353675365447998, 0.09298259019851685, -0.05378386378288269, -0.022907428443431854, -0.13791954517364502, 0.16834181547164917, 0.03637503832578659, -0.030332786962389946, -0.05044832453131676, -0.033985573798418045, -0.019404321908950806, -0.023301396518945694, -0.03979939967393875, -0.023323994129896164, -0.015952499583363533, 0.025747336447238922, 0.034087155014276505, -0.007439053617417812, 0.039950575679540634, 0.03379805013537407, -0.03759840875864029, 0.017109589651226997, 0.038096506148576736, 0.04134511202573776, -0.01178770512342453, 0.04058631882071495, -0.04459710419178009, 0.014348644763231277, 0.036811988800764084, -0.03186215087771416, -0.003502465784549713, -0.03084668703377247, -0.07535076141357422, 0.05161242187023163, -0.04165764898061752, 0.06461009383201599, -0.033726587891578674, 0.09586012363433838, -0.06224612891674042, 0.09485083073377609, -0.14658567309379578, 0.03847184032201767, 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Transferrin\tmolecules\tare\tgenerated\ton\tthe\tsurface\tof\tRBCs\tin\tresponse\tto\tthe\tneed\tfor\tiron.\tWith\niron\tdeficiency,\tso\tmany\t\ntransferrin\treceptors\n\tare\ton\tthe\tcell\tsurface\tunbound\tto\tiron\tthat\tsome\tof\nthem\tbreak\toff\tand\tfloat\tin\tthe\tserum.\tTheir\tpresence\tis\tan\tearly\tsign\tof\tdeveloping\tiron\tdeficiency;\ta\nhigher\tquantity\n\tof
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0.03828791156411171, -0.05399847403168678, 0.07412559539079666, 0.11290246248245239, -0.029957378283143044, -0.048763010650873184, 0.08823512494564056, 0.004094449337571859, -0.05747495964169502, -0.007774963974952698, 0.06629663705825806, -0.01742827706038952, -0.029602767899632454, -0.024523157626390457, 0.017311306670308113, 0.019490279257297516, 0.020830832421779633, -0.03234574571251869, 0.049651771783828735, 0.037730906158685684, 0.09384214878082275, 0.06821992248296738, -0.0015584429493173957 ]
higher\tquantity\n\tof\t\nsoluble\tserum\ttransferrin\treceptors\t(STFRs)\n\tmeans\tgreater\tdeficiency\tof\tiron.\nProgressive\tstages\tof\tiron\tdeficiency\tcan\tbe\tevaluated\tby\tmeasurements,\tas\tshown\tin\t\nTable\t31.2\n.\nTABLE\t31.2\nBiochemical\tEvaluation\tof\tIron\tDeficiency\nMeasure\nReference\nRange\nDeficiency\nSerum\tor\nplasma\nferritin\nNewborn\t25-200\nng/mL;\t25-\n200\tmcg/dL
[ -0.019930405542254448, -0.09846668690443039, -0.028133254498243332, -0.040844645351171494, -0.10533822327852249, -0.04703100398182869, -0.011317910626530647, 0.08343726396560669, -0.028706390410661697, 0.03802591562271118, 0.03646022081375122, -0.03159740939736366, 0.020944299176335335, 0.052731964737176895, -0.07650038599967957, -0.06378169357776642, 0.0021881628781557083, 0.0288316011428833, -0.06557157635688782, -0.013466833159327507, 0.059688594192266464, 0.0378335677087307, 0.01995868980884552, -0.0014254444977268577, 0.05441533774137497, -0.006506088189780712, -0.09966279566287994, 0.05594009906053543, 0.019142597913742065, -0.06940093636512756, -0.10717581957578659, 0.09408862888813019, -0.006962780375033617, -0.028196778148412704, 0.0644623413681984, 0.025016309693455696, -0.06128135696053505, 0.014822455123066902, 0.039145614951848984, -0.00012819052790291607, 0.010570831596851349, -0.06854894012212753, 0.019229035824537277, 0.021615969017148018, 0.05845623090863228, 0.007885917089879513, -0.01810808666050434, -0.06228387728333473, -0.03232087194919586, -0.0010568298166617751, -0.02893826551735401, 0.031118741258978844, -0.07735752314329147, 0.059253860265016556, 0.015196128748357296, 0.023895936086773872, -0.04697207361459732, -0.013051762245595455, -0.04697528854012489, -0.013320937752723694, -0.008705759420990944, 0.00013281895371619612, -0.056243304163217545, -0.004140123724937439, 0.016518453136086464, 0.07298120856285095, -0.05128853768110275, -0.0014607785269618034, -0.028922690078616142, 0.10167431831359863, 0.006742986850440502, -0.009389173239469528, -0.11692778766155243, 0.10169033706188202, 0.011247754096984863, 0.04325970262289047, 0.09829805046319962, -0.029145652428269386, 0.00901658833026886, -0.0396176315844059, -0.07704091817140579, 0.0849800705909729, -0.0006943073240108788, 0.00022668702877126634, -0.010499141179025173, -0.01373266614973545, 0.028219280764460564, 0.06427102535963058, 0.03699326515197754, -0.013672323897480965, 0.09187882393598557, 0.03193952143192291, -0.06455135345458984, -0.03696546331048012, -0.0463426373898983, 0.02192106656730175, -0.0032878145575523376, -0.04985613003373146, 0.016083039343357086, -0.002728591440245509, -0.013071912340819836, -0.00575017835944891, -0.01995922066271305, 0.002531664911657572, -0.09641478210687637, -0.04742864519357681, 0.049552544951438904, -0.00801637303084135, 0.03977826610207558, 0.010092651471495628, -0.022560035809874535, 0.001834405236877501, 0.014207686297595501, -0.03424130007624626, -0.035233378410339355, -0.0364130400121212, -0.08277878165245056, 0.002232189988717437, 0.13547684252262115, 0.02274901233613491, 0.011598021723330021, -0.02182866260409355, -0.009035221301019192, 0.026707878336310387, -0.06406642496585846, -0.041369352489709854, -0.02828982099890709, 3.452519111203201e-33, 0.005498745013028383, 0.06882736086845398, 0.016281604766845703, 0.0473533570766449, 0.0007808381342329085, -0.00005585092003457248, -0.030744381248950958, -0.06211213767528534, 0.02556023932993412, 0.05176224932074547, -0.13972531259059906, 0.041195064783096313, -0.05835800990462303, 0.05375077575445175, 0.07742992788553238, -0.06613133102655411, -0.04876893758773804, 0.0843052938580513, -0.013294159434735775, -0.010349787771701813, 0.0075303358025848866, 0.1067623645067215, 0.017557412385940552, -0.013314780779182911, 0.053847264498472214, -0.06434193253517151, -0.0014507774030789733, -0.04492153227329254, -0.09097199141979218, 0.030470550060272217, 0.015067392960190773, -0.028964024037122726, -0.04381842911243439, -0.02520573139190674, -0.02857854589819908, -0.026478715240955353, -0.056970056146383286, 0.013949877582490444, 0.06365402787923813, -0.027157844975590706, -0.009478534571826458, 0.0567503497004509, 0.04860997200012207, 0.04825681447982788, 0.016156665980815887, -0.011166336014866829, 0.02522221766412258, 0.003216538345441222, -0.032050397247076035, -0.04554431140422821, -0.06006168946623802, 0.008043003268539906, 0.08253701776266098, -0.03197767585515976, -0.010962306521832943, 0.035627786070108414, 0.027646591886878014, 0.018270744010806084, 0.007310063578188419, 0.14898091554641724, -0.06267695128917694, 0.08004823327064514, 0.00338221387937665, -0.03828370198607445, 0.009430025704205036, 0.03975551202893257, -0.15528331696987152, -0.045603420585393906, 0.05879899486899376, 0.00006568447133759037, -0.06065421178936958, -0.047281697392463684, 0.016351163387298584, 0.014178743585944176, 0.06138617545366287, 0.030938751995563507, 0.02589791640639305, -0.05986765772104263, -0.0129967937245965, -0.07352987676858902, -0.08371128886938095, 0.0018833911744877696, -0.04059434309601784, -0.0575302354991436, -0.03083305060863495, -0.08498134464025497, 0.04430815204977989, -0.04052865132689476, 0.0033112389501184225, -0.016306154429912567, -0.009955364279448986, -0.012975876219570637, -0.039793550968170166, -0.054090432822704315, -0.07852084934711456, -4.217887891127408e-33, -0.046903252601623535, 0.039152782410383224, 0.033652257174253464, 0.07058439403772354, -0.027003774419426918, -0.0048517342656850815, 0.021710732951760292, -0.039739470928907394, 0.09434065967798233, 0.0010929711861535907, 0.0990949347615242, 0.03542916849255562, -0.06166207790374756, -0.10157457739114761, -0.03877532109618187, 0.012799699790775776, -0.034189410507678986, 0.017254414036870003, -0.022348780184984207, -0.03740537539124489, -0.01134742982685566, 0.09806352108716965, -0.07796546816825867, 0.044589556753635406, 0.004271635320037603, 0.057487692683935165, -0.10924655944108963, 0.013504788279533386, 0.0213910099118948, 0.06361819058656693, -0.008565058931708336, -0.10338521003723145, -0.0063112773932516575, 0.1192391887307167, -0.00619465159252286, -0.0225585475564003, 0.0733444020152092, -0.019941169768571854, -0.022297866642475128, 0.00012600603804457933, 0.08464890718460083, 0.002676396630704403, 0.06550220400094986, 0.02415977604687214, 0.02807462029159069, -0.04386400058865547, -0.027804048731923103, -0.11848423629999161, 0.04544463008642197, 0.023040950298309326, 0.0912756398320198, 0.03211098909378052, -0.012367724440991879, 0.0505947507917881, 0.020924795418977737, -0.020856713876128197, 0.035884834825992584, -0.06509402394294739, -0.05984701216220856, -0.016739744693040848, 0.022862477228045464, -0.00501088984310627, 0.07451435178518295, -0.0026038263458758593, 0.03174324706196785, -0.04114748537540436, -0.04670223593711853, -0.0642157644033432, -0.004273927770555019, -0.031177785247564316, -0.03734830021858215, 0.03074125573039055, 0.0304963830858469, -0.11943917721509933, 0.04051216319203377, -0.046474117785692215, 0.06596328318119049, -0.009573637507855892, -0.013974003493785858, -0.03557011857628822, -0.06574418395757675, -0.0038985733408480883, 0.013294432312250137, 0.039635565131902695, 0.0026984168216586113, 0.0027698250487446785, 0.028008757159113884, -0.005585027858614922, 0.04798765853047371, 0.04110046103596687, -0.005451434291899204, 0.016891641542315483, 0.02621639519929886, 0.04893885925412178, 0.02502485364675522, -5.072826070318115e-8, -0.023173268884420395, -0.03688489645719528, 0.008895155042409897, -0.021121524274349213, 0.023148465901613235, -0.044413696974515915, 0.026300353929400444, 0.057080358266830444, 0.039712969213724136, -0.0409000962972641, 0.08426196128129959, 0.02742159739136696, -0.07511252909898758, -0.0555453896522522, 0.06352206319570541, 0.027287928387522697, -0.06928552687168121, 0.11174167692661285, -0.04122084379196167, -0.08808047324419022, -0.008258748799562454, 0.045393068343400955, -0.0076568834483623505, 0.018398305401206017, -0.005300816614180803, -0.05544813349843025, -0.023620035499334335, -0.0021555854473263025, 0.04781494289636612, 0.07793361693620682, 0.07359981536865234, -0.08517904579639435, 0.06973347067832947, -0.011110366322100163, 0.03217877447605133, 0.044151872396469116, -0.052485909312963486, 0.0002893409982789308, -0.03425009176135063, 0.12540839612483978, -0.04572209343314171, -0.04314221814274788, -0.03885011002421379, 0.09658122807741165, 0.15591996908187866, -0.059334803372621536, -0.0946422666311264, 0.0935024544596672, -0.005619782488793135, -0.07872921973466873, -0.007785988971590996, 0.07038252055644989, -0.017797037959098816, -0.04973701760172844, -0.07120385766029358, 0.06253855675458908, -0.026206010952591896, 0.019333919510245323, -0.021023442968726158, -0.0019885478541254997, 0.06673800945281982, 0.02166653238236904, 0.07434096187353134, -0.013971284963190556 ]
Serum\tor\nplasma\nferritin\nNewborn\t25-200\nng/mL;\t25-\n200\tmcg/dL\nNeonate\t–\t5\nmos\n50-200\nng/mL;\n50-200\nmcg/dL\n6\tmos-15\tyr\n7-142\nng/mL;\t7-\n142\nmcg/dL\nF\t15\tyr\t+\t10-\n150\nng/mL;\n10-150\nmcg/dL\nM\t15\tyr\t+\n12-300\nng/mL;\n12-300\nmcg/dL\nThe\tmost\tsensitive\tindicator\tof\tiron\tdeficiency.\tLow\tlevels\tof\tferritin\nare\talso\tseen\tin\tsevere\tprotein\tdepletion.
[ -0.04747302830219269, -0.048790570348501205, -0.019478000700473785, -0.07911456376314163, -0.04570693150162697, 0.000734823988750577, 0.03740687668323517, 0.10216473042964935, -0.06774009019136429, 0.018204743042588234, 0.10357211530208588, -0.05473167821764946, 0.02613818272948265, 0.0545671172440052, -0.11129196733236313, -0.03339604660868645, -0.026559948921203613, -0.0029468180146068335, -0.04970468208193779, -0.04026385396718979, 0.0024833609350025654, 0.02507004514336586, -0.037093501538038254, -0.0026005117688328028, 0.01622680202126503, 0.004160676617175341, -0.022251321002840996, 0.021398652344942093, 0.0011048463638871908, -0.07006579637527466, -0.06852211803197861, 0.02003851905465126, -0.025565804913640022, -0.05567406490445137, 0.056468117982149124, -0.003686804324388504, -0.08991816639900208, 0.042980730533599854, -0.028676917776465416, 0.01845458894968033, 0.11147767305374146, -0.10858630388975143, -0.039546966552734375, -0.008364367298781872, 0.07288792729377747, -0.03090122528374195, -0.05945344641804695, 0.03952057287096977, 0.025328438729047775, 0.0645233690738678, -0.049537502229213715, -0.01581665687263012, -0.0502023845911026, 0.11139221489429474, -0.029286673292517662, -0.018308669328689575, -0.08678653091192245, -0.06043907254934311, -0.013674892485141754, 0.006186512764543295, -0.06613264977931976, 0.008055723272264004, -0.06858718395233154, 0.015360821969807148, 0.04919788986444473, 0.013535335659980774, 0.022116651758551598, -0.043799735605716705, 0.01788521558046341, 0.03523173928260803, -0.03686552122235298, -0.023276260122656822, -0.012867049314081669, 0.11376798152923584, -0.031318239867687225, 0.08522649109363556, 0.015675852075219154, -0.06198152154684067, 0.017882561311125755, 0.005870525725185871, -0.01011995505541563, 0.080081045627594, 0.05168917402625084, 0.08129990845918655, -0.006412769202142954, 0.011885861866176128, -0.024577252566814423, 0.09415575861930847, 0.030910193920135498, 0.012334843166172504, 0.09963947534561157, 0.0011942157289013267, -0.06413271278142929, -0.02492344193160534, -0.03816996142268181, 0.0026582269929349422, -0.03435296192765236, 0.02577248029410839, 0.03160955011844635, 0.016957487910985947, -0.058660440146923065, -0.10879835486412048, -0.013623066246509552, -0.05349895730614662, -0.08589702099561691, -0.04650263115763664, 0.025149142369627953, -0.010275505483150482, 0.011396600864827633, 0.0030273699667304754, -0.02575373649597168, 0.03145187348127365, 0.043171390891075134, -0.054040972143411636, 0.04765314608812332, -0.021548084914684296, 0.038008298724889755, -0.0016305041499435902, 0.12051520496606827, 0.03900324925780296, 0.03660473972558975, -0.0011246131034567952, 0.00934769306331873, 0.020472327247262, -0.019509483128786087, 0.05729417875409126, -0.03709470108151436, 3.6568391311593155e-33, 0.043655361980199814, 0.06937055289745331, 0.01570606604218483, 0.12252359837293625, -0.05343754217028618, 0.06924297660589218, -0.001684148097410798, -0.033727217465639114, -0.02306481823325157, 0.0640278309583664, -0.11787974089384079, 0.004228834994137287, -0.017296696081757545, 0.11748006194829941, -0.0062582227401435375, -0.07825089246034622, 0.06238618120551109, 0.010853992775082588, -0.028722962364554405, -0.04492568597197533, 0.04205998033285141, 0.10441552102565765, -0.031455349177122116, -0.01438259705901146, -0.01739848218858242, 0.0611112155020237, -0.019617518410086632, 0.03699514642357826, 0.00808092299848795, 0.016150161623954773, 0.012746120803058147, -0.05423582345247269, -0.04404144361615181, 0.00011155665561091155, -0.03683048114180565, 0.011701191775500774, -0.027850547805428505, -0.018275968730449677, 0.0769183337688446, 0.01342624332755804, 0.04323795810341835, 0.06589224189519882, 0.03228053078055382, 0.004411898087710142, 0.023648252710700035, -0.035989489406347275, -0.037740934640169144, -0.03555662930011749, 0.020678536966443062, -0.04368218407034874, -0.026343710720539093, 0.01349325105547905, 0.04077333211898804, -0.02775578200817108, -0.0674501582980156, 0.01951284520328045, -0.11062029004096985, 0.052004702389240265, 0.041251085698604584, 0.09493512660264969, -0.036076124757528305, 0.0696907788515091, -0.023691093549132347, -0.009316262789070606, 0.06906144320964813, 0.02315833978354931, -0.12587368488311768, -0.06377487629652023, -0.004402524325996637, -0.029531627893447876, -0.04360037297010422, 0.007101577240973711, 0.08656643331050873, 0.010668205097317696, 0.06938008964061737, 0.03236357495188713, 0.048388831317424774, -0.011384444311261177, -0.06400138139724731, -0.12256550788879395, -0.051636435091495514, 0.006225467659533024, -0.002992762718349695, 0.048829566687345505, 0.047455303370952606, -0.10703257471323013, -0.024399669840931892, -0.03819691762328148, -0.06662528216838837, -0.07356555759906769, 0.006056141573935747, -0.0034289525356143713, -0.08651132136583328, -0.03546515107154846, -0.126770481467247, -4.476372119375521e-33, -0.00247740070335567, 0.0114538399502635, 0.03788590058684349, 0.004252544138580561, -0.020257679745554924, 0.04334124177694321, 0.07069503515958786, 0.038123998790979385, 0.06349535286426544, 0.0724315419793129, 0.11573995649814606, -0.001309498562477529, -0.08949746191501617, -0.09887143969535828, -0.03660298138856888, 0.010048980824649334, -0.06088826432824135, 0.05279271677136421, -0.01492299884557724, -0.06703007966279984, -0.13064995408058167, 0.11875299364328384, -0.014579977840185165, 0.06387531757354736, 0.0022453314159065485, 0.05758315697312355, -0.022283885627985, -0.003885885002091527, 0.0503690205514431, 0.07716089487075806, -0.015577380545437336, -0.05911359563469887, -0.00903666764497757, 0.09394149482250214, -0.04509637504816055, -0.030256927013397217, 0.04739431291818619, -0.012373817153275013, 0.03900007903575897, 0.03416987881064415, 0.039862170815467834, -0.06556348502635956, 0.04751409962773323, -0.041444871574640274, -0.000689258857164532, -0.010038239881396294, -0.0003196161997038871, -0.11898529529571533, 0.026376167312264442, -0.015816008672118187, 0.03294304385781288, -0.02588297426700592, -0.017601866275072098, 0.061017148196697235, -0.026103176176548004, -0.03299823775887489, 0.05914005637168884, -0.07107039541006088, -0.030627377331256866, -0.04916589707136154, 0.04432876408100128, 0.001159014762379229, 0.028951378539204597, -0.0318727120757103, 0.04863966628909111, -0.006852053105831146, 0.02435772679746151, -0.05341764912009239, 0.0038310035597532988, -0.012537019327282906, -0.03348686546087265, -0.010787203907966614, 0.010253170505166054, -0.07358130067586899, 0.07936222106218338, -0.08579694479703903, 0.04671159386634827, -0.009606550447642803, 0.030228670686483383, -0.04486618563532829, -0.01661490648984909, -0.08051733672618866, -0.015800919383764267, -0.008576191030442715, 0.056463826447725296, -0.02579388953745365, 0.03657005727291107, 0.018373550847172737, 0.0017349871341139078, 0.0762074738740921, -0.00028280867263674736, 0.06932531297206879, 0.038792651146650314, 0.06650371849536896, 0.047924190759658813, -5.102277711444003e-8, 0.07994120568037033, -0.027691399678587914, -0.02010425552725792, -0.006127763073891401, -0.013538953848183155, 0.01787910982966423, 0.019736789166927338, 0.031498055905103683, 0.02757614478468895, 0.0004967026761732996, 0.06032288447022438, 0.030097506940364838, -0.05159679055213928, -0.07671767473220825, 0.0166483111679554, -0.004824422299861908, -0.1032148152589798, 0.06258762627840042, -0.06725147366523743, -0.1131545752286911, -0.012534982524812222, 0.08119513094425201, -0.005080876871943474, -0.007422845810651779, 0.018630871549248695, -0.02451598271727562, -0.002135320333763957, 0.02380877546966076, 0.010242548771202564, 0.048523422330617905, -0.009362343698740005, -0.041409313678741455, 0.0024558459408581257, -0.007816226221621037, -0.029109615832567215, 0.05171913281083107, -0.031120864674448967, -0.022428035736083984, -0.013015680015087128, 0.12140262126922607, -0.041831228882074356, -0.07401464134454727, -0.03124925307929516, 0.04897035285830498, 0.12408249825239182, -0.08260821551084518, -0.04658371955156326, 0.06090351566672325, 0.0008924768189899623, -0.050918467342853546, -0.0005538667319342494, 0.05323571711778641, -0.016232958063483238, -0.03728637099266052, -0.1103903278708458, -0.016846882179379463, -0.01708056963980198, 0.03286847472190857, 0.030045202001929283, -0.01216935645788908, 0.017599215731024742, 0.013520411215722561, 0.040847085416316986, -0.029179144650697708 ]
are\talso\tseen\tin\tsevere\tprotein\tdepletion.\nFemales\t–\t<\t10\tmcg/dL\nMales\t–\t<\t12\tmcg/dL\nSerum\tor\nplasma\tiron\nF\t40-150\nmcg/dL;\t7.2-\n26.9\tmmol/L\nM\t50-160\nmcg/dL;\n8.9-28.7\nmmol/L\nA\tgood\tmeasure\tof\tquantity\tof\tiron\tbound\tto\ttransferrin.\nFemales\t–\t<\t40\tmcg/dL\nMales\t–\t<50\tmcg/dL\nTotal\tiron-\nbinding\ncapacity\n(TIBC)\n250-460\tmcg/dL;\n45-82\tmmol/L
[ -0.04816485568881035, -0.05155649036169052, -0.0015021945582702756, -0.06320147216320038, -0.13649073243141174, -0.020046187564730644, 0.0295686237514019, 0.08010905981063843, -0.03381616622209549, 0.02085454761981964, 0.06351722031831741, -0.006301832385361195, 0.08725550770759583, 0.03617844730615616, -0.05892758443951607, 0.01242533978074789, -0.015130640007555485, 0.018882106989622116, -0.09423751384019852, -0.05813997983932495, 0.029971230775117874, 0.034400638192892075, -0.010512934997677803, -0.019370511174201965, 0.029697086662054062, 0.01211260724812746, -0.052752021700143814, 0.06646527349948883, -0.017444638535380363, -0.085138700902462, -0.10788866877555847, 0.03687768429517746, -0.030584946274757385, -0.04205583408474922, 0.07463695108890533, 0.020721543580293655, -0.08463675528764725, -0.009034242480993271, 0.015476454980671406, 0.022043736651539803, 0.0356416255235672, -0.05685219541192055, 0.013367610983550549, 0.007945491932332516, 0.021914007142186165, 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0.033754169940948486, 0.028508152812719345, -0.03956238552927971, -0.029825512319803238, 0.004519561771303415, 0.021742023527622223, 0.020550332963466644, 0.010602492839097977, 0.14014288783073425, -0.013978690840303898, 0.09421658515930176, 0.01747661828994751, -0.08564484864473343, 0.074050173163414, 0.031995076686143875, -0.0781586542725563, -0.03685586526989937, 0.0579545795917511, -0.03162283077836037, -0.040758054703474045, -0.05028268322348595, 0.09108339995145798, 0.03637681156396866, 0.07939887791872025, 0.023160593584179878, 0.03891957923769951, -0.049331896007061005, 0.03048531897366047, -0.14312763512134552, -0.0475798100233078, -0.019073141738772392, -0.0017527100862935185, -0.04706970229744911, 0.047381218522787094, -0.09793564677238464, 0.017130989581346512, -0.04763325676321983, -0.04926443099975586, 0.021363064646720886, -0.055837441235780716, -0.006367203313857317, -0.03641430661082268, -0.035579614341259, -0.10950249433517456, -4.993158006905385e-33, -0.03371986374258995, 0.07336843758821487, 0.04899042844772339, 0.0430937334895134, -0.0543152280151844, 0.0050363256596028805, 0.03135976567864418, -0.025962432846426964, 0.07294239103794098, 0.06321857869625092, 0.13675455749034882, 0.009225045330822468, -0.05988156795501709, -0.07830136269330978, -0.006072201766073704, -0.004073810763657093, -0.07717002183198929, 0.0147261843085289, -0.007820067927241325, -0.035840269178152084, -0.0808585062623024, 0.059787169098854065, -0.023824144154787064, 0.06619659066200256, -0.005664342548698187, 0.035686053335666656, -0.06634457409381866, 0.05887642130255699, 0.05118352174758911, 0.06674528867006302, -0.011342031881213188, -0.092308908700943, 0.00988391786813736, 0.09125982969999313, -0.039989057928323746, -0.03525993227958679, 0.03749305009841919, 0.047839224338531494, 0.06308197230100632, -0.027200782671570778, 0.06397632509469986, -0.03238988295197487, 0.06523483246564865, -0.020609870553016663, -0.02696773037314415, 0.006719515658915043, 0.00964827835559845, -0.1289473921060562, -0.06959932297468185, 0.01453469879925251, 0.08350376039743423, 0.04306868091225624, -0.03961436077952385, 0.03619809448719025, 0.008130225352942944, 0.00993157085031271, -0.010327314026653767, -0.0832618996500969, -0.049607254564762115, -0.06929156929254532, -0.0009700061636976898, 0.009955431334674358, 0.07930612564086914, -0.048445940017700195, 0.049582675099372864, -0.00786793977022171, -0.03812074661254883, -0.054134588688611984, 0.028938939794898033, -0.014064181596040726, -0.018401551991701126, 0.029230162501335144, 0.02901545539498329, -0.10494276136159897, 0.07167471945285797, -0.1000775396823883, 0.08967646956443787, -0.04042045399546623, 0.002275957027450204, -0.01924045942723751, -0.05657792463898659, 0.029904380440711975, 0.005662631709128618, 0.02982260286808014, -0.018963484093546867, 0.006441797129809856, 0.006169337313622236, 0.041636500507593155, 0.05202470347285271, 0.09900540113449097, 0.04216211289167404, 0.11130417883396149, 0.1007600948214531, 0.10099196434020996, 0.040359675884246826, -5.43350289206046e-8, -0.025827646255493164, 0.021105578169226646, -0.028682881966233253, 0.004479854367673397, 0.0026704201009124517, -0.020119840279221535, 0.02640070579946041, 0.02712356112897396, 0.009043673053383827, -0.03416895866394043, 0.10311953723430634, -0.007795779965817928, -0.0728776603937149, -0.0368754006922245, 0.011753314174711704, -0.014133058488368988, -0.07872430235147476, 0.09021063148975372, -0.020904870703816414, -0.06936421990394592, 0.007264592684805393, 0.04979759082198143, 0.051173266023397446, 0.02076118066906929, 0.007124550174921751, -0.05345157906413078, -0.08853857219219208, -0.027315793558955193, 0.017454219982028008, 0.04605266824364662, -0.00454985536634922, -0.060130663216114044, 0.014387397095561028, 0.025344563648104668, 0.01104857586324215, 0.0012875576503574848, -0.06610909104347229, 0.00622093491256237, -0.009476128965616226, 0.1426953673362732, -0.003519912716001272, -0.04473571479320526, -0.047275397926568985, 0.068695068359375, 0.09948679059743881, -0.05310337245464325, -0.06755606830120087, 0.050236400216817856, -0.003545904066413641, -0.013573388569056988, 0.01206300314515829, 0.09134051948785782, 0.017397422343492508, -0.04024498537182808, -0.02761721797287464, -0.008382251486182213, -0.07912253588438034, 0.027561809867620468, 0.0035066097043454647, 0.04245837405323982, -0.05365375801920891, 0.033392392098903656, 0.029755961149930954, -0.05298107862472534 ]
Total\tiron-\nbinding\ncapacity\n(TIBC)\n250-460\tmcg/dL;\n45-82\tmmol/L\nTIBC\tprimarily\treflects\tliver\tfunction\tand\tis\tan\tindirect\tmeasurement\nof\ttransferrin.\nIncreases\twith\tiron-deficiency\tanemia.\nTransferrin\nsaturation\nF\t15%-50%\nM\t20%-50%\nMeasures\tthe\tiron\tsupply\tto\tthe\ttissues.\nCalculated\tby\tdividing\tserum\tiron\tby\tthe\tTIBC\tmultiplied\tby\t100.
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Calculated\tby\tdividing\tserum\tiron\tby\tthe\tTIBC\tmultiplied\tby\t100.\nLevels\tless\n\tthan\t16%\tare\tconsidered\tinadequate\tfor\terythropoiesis.\nSoluble\tserum\ntransferrin\nreceptor\n(STFR)\nF\t1.9-4.4\tmg/L\nM\t2.2-5\tmg/L\nSTFR\treflects\tthe\trate\tof\tred\tblood\tcell\t(RBC)\tproduction\tin\tbone\nmarrow.\tOrdered\tto\tdifferentiate\tbetween\tiron\tdeficiency\tanemia
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0.0009144896757788956, -0.009088270366191864, 0.04416840523481369, 0.09053491055965424, -6.165029731164395e-8, 0.018230529502034187, -0.00560748903080821, -0.03102000616490841, -0.028996272012591362, 0.011805959977209568, 0.003560998709872365, -0.017539579421281815, 0.029257195070385933, 0.011497477069497108, -0.028958363458514214, 0.037427015602588654, 0.08909665048122406, -0.032043714076280594, -0.08224458992481232, 0.02265947312116623, 0.03957727551460266, -0.013150653801858425, 0.093019999563694, -0.0013132395688444376, -0.10945552587509155, 0.007548253983259201, 0.006446999963372946, 0.016522778198122978, -0.003183606779202819, -0.02335427887737751, 0.011750447563827038, -0.01691039651632309, -0.036152586340904236, 0.017446408048272133, 0.0025999504141509533, 0.07051487267017365, -0.09053678810596466, 0.04476327449083328, 0.0019715444650501013, 0.01207774505019188, 0.013327299617230892, -0.021406766027212143, 0.03317032381892204, 0.01989368535578251, 0.1113583967089653, -0.08058048039674759, -0.03208975866436958, -0.024992844089865685, 0.0632266029715538, 0.08402037620544434, -0.006929128430783749, -0.09224073588848114, 0.05657830461859703, -0.012354864738881588, -0.11395023763179779, 0.012652773410081863, 0.046336691826581955, -0.05542756989598274, -0.00660391990095377, -0.03600084409117699, 0.09160249680280685, 0.032274018973112106, 0.004703810438513756, -0.00763053959235549, 0.0127251660451293, 0.04386948421597481, 0.06220092996954918, 0.03908045217394829, -0.03501086309552193 ]
marrow.\tOrdered\tto\tdifferentiate\tbetween\tiron\tdeficiency\tanemia\nand\tanemia\tof\tchronic\tdisease.\nMore\tsensitive\tthan\tserum\tferritin\tbecause\tit\tis\televated\twith\tiron\ndeficiency,\tis\twithin\tnormal\tlimits\t(WNL)\n\tin\tchronic\tdisease\tor\ninflammation,\tand\tis\tlow\twith\tiron\toverload.\nCreated\twith\tassistance\tby\tMary\tLitchford,\tPhD,\tRDN,\tLDN.\nProtoporphyrin
[ -0.03351246193051338, -0.04148565232753754, 0.021620187908411026, -0.028229128569364548, -0.09159248322248459, 0.007011984474956989, 0.07262501865625381, 0.07626587897539139, -0.03184051066637039, 0.0756111890077591, 0.09436236321926117, 0.003563442500308156, -0.016639523208141327, 0.0412641242146492, -0.055631086230278015, -0.008142521604895592, 0.03166697546839714, 0.017442332580685616, -0.11141910403966904, -0.019522512331604958, -0.031532954424619675, 0.059877440333366394, 0.04408634081482887, -0.025858188048005104, 0.07511399686336517, -0.01645282655954361, -0.06955821812152863, -0.012850134633481503, 0.04221856966614723, -0.016348153352737427, -0.07019712030887604, 0.04862893745303154, -0.022577889263629913, -0.016817063093185425, 0.040540069341659546, 0.04764379560947418, -0.03372437134385109, -0.010074010118842125, 0.010690275579690933, 0.0344083309173584, 0.038406770676374435, -0.08324863016605377, -0.07724206894636154, 0.04019693285226822, 0.04072001203894615, 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0.10945728421211243, -0.04160270839929581, -0.004525812342762947, 0.00786900520324707, -0.009808460250496864, 0.06340990960597992, 0.011860140599310398, 0.12740759551525116, -0.009282481856644154, 0.06533624976873398, 0.012582010589540005, 0.010348116979002953, 0.022416500374674797, -0.03983721882104874, -0.1313992738723755, -0.05022767558693886, -0.015159038826823235, -0.03294811397790909, -0.052781928330659866, -0.012453603558242321, 0.0016658594831824303, 0.03512527048587799, 0.07668019086122513, 0.015595114789903164, 0.03583839535713196, -0.025824645534157753, -0.05836235359311104, -0.10477513819932938, -0.0550190694630146, -0.054522886872291565, -0.04234691709280014, -0.0030570838134735823, -0.024000173434615135, -0.03628649190068245, -0.00006938134174561128, -0.06586027890443802, -0.03664404898881912, -0.06588702648878098, 0.0041638948023319244, 0.04629948362708092, -0.04491854086518288, -0.11496102064847946, -0.09000986814498901, -2.8562372957921105e-33, -0.023961305618286133, 0.004034129902720451, -0.058695148676633835, 0.0194271057844162, -0.03484899178147316, 0.022144734859466553, 0.008284332230687141, 0.022635407745838165, 0.051438167691230774, -0.001555355847813189, 0.11033165454864502, 0.021950028836727142, -0.1196981817483902, -0.06492464989423752, -0.09212643653154373, -0.007184447254985571, 0.03391673415899277, 0.07699431478977203, -0.04844667762517929, 0.013232110068202019, -0.06145460158586502, 0.04240713641047478, -0.10820910334587097, 0.05710364133119583, 0.04306446760892868, 0.08802233636379242, -0.008125916123390198, 0.0011229084338992834, 0.041128676384687424, 0.012347680516541004, 0.008747939020395279, -0.04540850967168808, -0.03440714627504349, -0.01951337605714798, 0.015054069459438324, 0.023411575704813004, 0.09428300708532333, -0.040457066148519516, -0.0710076242685318, -0.05347641929984093, 0.03171190991997719, -0.04252014681696892, 0.09602652490139008, 0.043268050998449326, 0.06555359810590744, 0.014140515588223934, 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0.026996057480573654, -0.009476209059357643, 0.02975401096045971, 0.12513116002082825, -4.817094989562065e-8, 0.051729582250118256, 0.009079414419829845, -0.04789064824581146, -0.044547781348228455, 0.028190337121486664, -0.035378217697143555, 0.023303788155317307, 0.06646126508712769, -0.026817958801984787, -0.01209013070911169, 0.015038515441119671, 0.13583604991436005, -0.06747694313526154, -0.03776867315173149, 0.09868316352367401, 0.07753747701644897, -0.02240341156721115, 0.05571184679865837, 0.010583699680864811, -0.06872057169675827, -0.04042073339223862, 0.07315754145383835, 0.033459149301052094, -0.0384683720767498, -0.0523221492767334, 0.01410218421369791, -0.011352334171533585, -0.06310701370239258, 0.055554721504449844, 0.02544599026441574, 0.06633207201957703, -0.033622853457927704, 0.04058848321437836, -0.04032755643129349, -0.03356070816516876, 0.024895010516047478, -0.03982509672641754, -0.011837002821266651, 0.006669085472822189, 0.0582168847322464, -0.021579723805189133, -0.006039333529770374, -0.01804989203810692, 0.0786588117480278, 0.0935472920536995, -0.0598183311522007, 0.02580084279179573, 0.09415746480226517, 0.009345638565719128, -0.10546491295099258, -0.020000062882900238, 0.06997226178646088, -0.003901260206475854, -0.05882668122649193, -0.05137758329510689, 0.07531485706567764, 0.09161565452814102, 0.002326879883185029, -0.019767792895436287, 0.020069405436515808, 0.04884753003716469, 0.05711925029754639, 0.05000924691557884, 0.01003790833055973 ]
Protoporphyrin\n\tis\tthe\tiron-containing\tportion\tof\tthe\trespiratory\tpigments\tthat\tcombines\twith\nprotein\tto\tform\themoglobin\tor\tmyoglobin.\tThe\tzinc\tprotoporphyrin\t(ZnPP)/heme\tratio\tis\tmeasured\tto\nassess\tiron\tdeficiency.\tHowever,\tboth\tthis\tZnPP/heme\tratio\tand\themoglobin\n\tlevels\tare\taffected\tby
[ -0.012910058721899986, -0.0401030071079731, -0.0069436123594641685, -0.029338538646697998, -0.014881225302815437, 0.021283170208334923, 0.06966280192136765, 0.09968400001525879, -0.009997461922466755, 0.09098807722330093, 0.06544896215200424, -0.007060410920530558, -0.05660678818821907, 0.06521111726760864, -0.07890699803829193, -0.019483547657728195, -0.04788357391953468, 0.019388778135180473, -0.08176907896995544, -0.04261018708348274, 0.009768390096724033, 0.1310161054134369, 0.03636709973216057, 0.011467104777693748, 0.051095135509967804, -0.02650623396039009, -0.00802469439804554, -0.017363794147968292, 0.010083535686135292, -0.014747405424714088, -0.08793121576309204, 0.040536511689424515, -0.0038649230264127254, 0.006744223181158304, 0.03026275336742401, 0.03699168190360069, -0.02150724269449711, -0.03342057764530182, 0.005959101486951113, -0.021040702238678932, 0.09554532915353775, -0.0803622454404831, -0.12616735696792603, -0.008467390201985836, 0.038622912019491196, 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levels\tare\taffected\tby\nchronic\tinfection\tand\tother\tfactors\tthat\tcan\tproduce\ta\tcondition\tthat\tmimics\tiron\tdeficiency\tanemia\nwhen,\tin\tfact,\tiron\tis\tadequate.\nAt\thigher\taltitudes,\twhere\tthere\tis\ta\tlower\tavailability\tof\toxygen,\thematocrit\tand\themoglobin\tlevels\nincrease\tto\tadapt\t(\nRyan\tet\tal,\t2014
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increase\tto\tadapt\t(\nRyan\tet\tal,\t2014\n).\tThis\tmust\tbe\tconsidered\twhen\tassessing\tanemia.\tHigh\taltitude\nis\t4900\tto\t11,500\tfeet;\tvery\thigh\taltitude\n\tis\t11,500\tto\t18,000\tfeet;\textreme\taltitude\tis\tabove\t18,000\nfeet.\nMedical\tmanagement\nTreatment\tof\tiron\tdeficiency\tanemia\tshould\tfocus\tprimarily\ton\tthe\tunderlying\tcause,\talthough\tthis\tis
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often\tdifficult\tto\tdetermine.\tThe\tgoal\tis\trepletion\tof\tiron\tstores.\nOral\tsupplementation.\nThe\tchief\ttreatment\tfor\tiron\tdeficiency\tanemia\tinvolves\toral\tadministration\tof\tinorganic\tiron\tin\tthe\nferrous\tform.\n\tAlthough\tthe\tbody\tuses\tferric\tand\tferrous\tiron,\tthe\treduced\tferrous\tis\teasier\ton\tthe\tgut
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and\tbetter\tabsorbed.\tAt\ta\tdose\tof\t30\tmg,\tabsorption\tof\tferrous\tiron\tis\tthree\ttimes\tgreater\tthan\tif\tthe
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same\tamount\twere\tgiven\tin\tthe\tferric\tform.\nIron\tis\tbest\tabsorbed\twhen\tthe\tstomach\tis\tempty.\tHowever,\tunder\tthese\tconditions\tit\ttends\tto\ncause\tgastric\tirritation,\twhich\tis\ta\tdirect\tresult\tof\tthe\thigh\tquantity\n\tof\tfree\tferrous\tiron\tin\tthe\nstomach.\tGastrointestinal\tside\teffects\tcan\tinclude\tnausea,\tepigastric\tdiscomfort\tand\tdistention,
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heartburn,\tdiarrhea,\tor\tconstipation.\tIf\tthese\tside\teffects\toccur,\tthe\tpatient\tis\ttold\tto\ttake\tthe\tiron\nwith\tmeals\tinstead\tof\ton\tan\tempty\tstomach;\thowever,\tthis\tsharply\treduces\tthe\tabsorbability\tof\tthe\niron.\tChelated\tforms\tof\tiron\t(combined\twith\tamino\tacids\tor\tKrebs\tcycle\n\tintermediaries)\tare\tmore
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intermediaries)\tare\tmore\nbioavailable\tthan\tnonchelated\tiron.\tChelated\tiron\tis\tless\taffected\tby\tinhibitors\tof\tiron\tabsorption,\nincluding\tphytate,\toxalate,\tphosphate,\tand\tcalcium.\tChelated\tiron,\tparticularly\tferrous\tbis\tglycinate,\ncauses\tless\tgastrointestinal\tdisturbances\tthan\telemental\tiron\tand\tit\tcan\tbe\tgiven\tin\ta\tlower\tdose\n(\nFerrari\tet\tal,\t2012
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0.02986649051308632, 0.024618646129965782, 0.016872132197022438, -0.07357440888881683, -0.03509673476219177, -0.025462713092565536, 0.041177280247211456, -0.0409468412399292, -0.008273070678114891, -0.0160836074501276, -0.020014725625514984, -0.002546542091295123, -0.01163988932967186, -0.007846319116652012, -0.044855233281850815, -0.006893992889672518, -0.03706534579396248, -0.09393741190433502, 0.016771381720900536, -0.005494466982781887, -0.023860028013586998, -0.013755707070231438, 0.0791935995221138, -0.0417296402156353, -0.06679748743772507, -0.005924636032432318, -0.03567378968000412, 0.011063512414693832, 0.13169161975383759, 0.0018966069910675287, -0.005963278003036976, -0.058683186769485474, -0.009491127915680408, 0.08650878816843033, -0.03661338984966278, -0.03269637003540993, -0.017343679443001747, 2.3626266467306926e-33, 0.03293094411492348, 0.05634109303355217, 0.007593848742544651, 0.02900317683815956, 0.0390017107129097, -0.001229583751410246, -0.05059194937348366, 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0.03651591017842293, 0.09810742735862732, 0.15049655735492706, -4.288720134582036e-8, 0.041701026260852814, -0.038990311324596405, -0.034697506576776505, -0.02328321523964405, 0.023092515766620636, -0.041016217321157455, 0.036639805883169174, 0.04132483899593353, -0.008947936818003654, -0.055652134120464325, 0.019094349816441536, 0.09232655167579651, -0.04459550976753235, -0.055422015488147736, 0.11135359853506088, 0.06917315721511841, -0.030162176117300987, 0.04430820047855377, -0.03520302474498749, -0.0322040319442749, -0.03933233395218849, 0.03948044404387474, -0.010151115246117115, 0.03355925530195236, -0.054231125861406326, -0.006363207474350929, -0.03075503371655941, -0.02003292366862297, 0.016542138531804085, 0.0015544821508228779, 0.043638940900564194, -0.03881234675645828, -0.006446317303925753, -0.0461338646709919, -0.02875417098402977, 0.046324100345373154, -0.058620572090148926, -0.017814477905631065, 0.002936172764748335, 0.11300338804721832, -0.022017063573002815, -0.03154454007744789, -0.05227495729923248, 0.06311886012554169, 0.054496653378009796, -0.04558827728033066, -0.036819975823163986, 0.09532369673252106, 0.035073328763246536, -0.08254816383123398, -0.004623814485967159, 0.10707979649305344, -0.004228798672556877, -0.07169055193662643, -0.02778114192187786, 0.03959505259990692, 0.06563839316368103, 0.023125896230340004, -0.00016280160343740135, 0.017272839322686195, 0.06052623689174652, 0.0765749141573906, 0.10636124759912491, -0.04264746978878975 ]
(\nFerrari\tet\tal,\t2012\n;\t\nMilman\tet\tal,\t2013\n).\tMicronutrient\tpowders\t(MNPs)\n\tcontaining\tiron\tmay\tbe\nuseful\tmethods\tof\thome\tfood\tfortification\tfor\tchildren\tunder\tage\t2\t(\nDe-Regil\tet\tal,\t2013\n).\tThe\tMNPs\ncan\tbe\tadded\tto\tsemisolid\tfoods\twithout\taffecting\tthe\tsensory\tappeal\tof\tthe\tfoods.\tVarious\tforms\tof\niron\tsupplements\tare\tdiscussed\tin\t\nTable\t31.3\n.
[ -0.04694890230894089, -0.030616674572229385, 0.02633672207593918, -0.027976814657449722, -0.06249435618519783, -0.0005267685046419501, 0.09795212000608444, -0.005201057996600866, -0.0018796693766489625, 0.02583914063870907, 0.14523959159851074, -0.0658051073551178, 0.0629386305809021, 0.0214155875146389, -0.03735712915658951, 0.012548414058983326, 0.006025776267051697, -0.015577100217342377, -0.04173055663704872, -0.060029108077287674, 0.011454514227807522, 0.08005043864250183, 0.05126141384243965, -0.02482462115585804, 0.03002997301518917, 0.04974347725510597, -0.061202287673950195, -0.028593871742486954, -0.014957078732550144, -0.037301938980817795, -0.07007656246423721, 0.06610926240682602, 0.01828855834901333, -0.02204023115336895, 0.09337922185659409, 0.05589820444583893, -0.06353424489498138, 0.023499591276049614, 0.05629634112119675, 0.022310594096779823, 0.015238218009471893, -0.10987604409456253, -0.018160808831453323, -0.029165763407945633, 0.056117117404937744, -0.01488894410431385, -0.019790489226579666, -0.001695143524557352, -0.026102760806679726, -0.030991151928901672, -0.06243368983268738, 0.02497074194252491, -0.04338363930583, 0.08543435484170914, 0.04078403115272522, -0.03181631863117218, -0.021247796714305878, -0.05671112611889839, -0.0538768507540226, 0.009052645415067673, -0.008567928336560726, -0.02604639157652855, -0.07631305605173111, 0.012996230274438858, 0.005366818979382515, 0.039487019181251526, -0.09107793867588043, 0.01967642270028591, -0.0028827213682234287, 0.06162913516163826, -0.09657569974660873, 0.02663225308060646, -0.06113022565841675, 0.12526331841945648, -0.061649806797504425, 0.023142648860812187, 0.08049929887056351, -0.07632956653833389, 0.019379865378141403, -0.04485594481229782, -0.09505978226661682, 0.05015040934085846, 0.032909076660871506, -0.011513739824295044, -0.029714934527873993, 0.027712684124708176, -0.027148311957716942, 0.05602329224348068, 0.0457049123942852, 0.0058585056103765965, 0.002894500270485878, -0.014366082847118378, 0.014359256252646446, -0.051847003400325775, -0.04929833114147186, -0.05035944655537605, -0.002728619845584035, -0.03333958610892296, -0.02883880026638508, 0.05159439891576767, -0.017064224928617477, 0.00941913016140461, -0.04426634684205055, -0.02737160585820675, -0.08757201582193375, -0.017581963911652565, -0.02647499367594719, -0.04204666614532471, 0.07758349925279617, 0.004022980574518442, -0.061896827071905136, 0.023333070799708366, 0.03743317350745201, -0.07953231036663055, -0.05044691637158394, -0.041575316339731216, -0.015414770692586899, -0.008353200741112232, 0.1645662933588028, 0.050871092826128006, 0.007542245555669069, 0.01495250966399908, -0.04952163249254227, 0.050818558782339096, -0.03635052591562271, 0.0020771867129951715, -0.009158246219158173, 2.8760671508065133e-33, 0.024122709408402443, 0.06591390073299408, 0.022039271891117096, 0.04731987416744232, 0.041505202651023865, 0.021331505849957466, -0.06633098423480988, -0.03044617734849453, -0.028682231903076172, 0.047547996044158936, -0.09614833444356918, -0.053304523229599, -0.04850415512919426, 0.06754160672426224, -0.012816088274121284, -0.12640966475009918, -0.01746080443263054, 0.07449593394994736, 0.003734339727088809, -0.001609093975275755, -0.041605979204177856, 0.13435959815979004, 0.030681192874908447, 0.014291947707533836, -0.07295972853899002, -0.03881596401333809, -0.009685076773166656, -0.023214122280478477, 0.0513598769903183, 0.036893393844366074, 0.06084876507520676, -0.05022231489419937, -0.07734094560146332, -0.02060123346745968, -0.060418322682380676, -0.031656015664339066, -0.03066493384540081, -0.024990303441882133, 0.019759895280003548, -0.027691030874848366, -0.06359412521123886, 0.04242587462067604, 0.006521100644022226, 0.0820685401558876, -0.01601690612733364, -0.003412851830944419, 0.031159786507487297, 0.0018227195832878351, 0.0004093479074072093, -0.02646803855895996, -0.005169741343706846, -0.028716279193758965, 0.05753134936094284, -0.012908725067973137, -0.05490977689623833, -0.00004517169145401567, -0.008181236684322357, 0.01508354302495718, 0.0005626330384984612, 0.07651551812887192, -0.015428557060658932, 0.0720292255282402, 0.013135302811861038, -0.07605402171611786, 0.05613119527697563, 0.004135378170758486, -0.09286634624004364, -0.05140524357557297, 0.06190483272075653, 0.013326629064977169, -0.019639011472463608, 0.032622262835502625, 0.04740893095731735, 0.006979729514569044, 0.07308060675859451, 0.004528909921646118, 0.03781542554497719, -0.0563691109418869, 0.017769278958439827, -0.06512444466352463, -0.021555816754698753, -0.05090522766113281, -0.003469947725534439, -0.029081914573907852, -0.046442631632089615, -0.02631271630525589, 0.02302311733365059, -0.08905618637800217, 0.019725263118743896, -0.0002049725007964298, -0.03532261401414871, 0.03590768948197365, -0.01039843074977398, -0.0590328611433506, -0.08285846561193466, -3.028475870862377e-33, -0.029459567740559578, -0.01808318682014942, -0.026968488469719887, 0.008933636359870434, -0.037861213088035583, -0.08054330199956894, -0.008439787663519382, -0.014580531045794487, 0.09791046380996704, -0.019236041232943535, 0.062148820608854294, 0.0072162761352956295, -0.011864504776895046, -0.1194634661078453, -0.03594629094004631, 0.04179548844695091, 0.02366778627038002, 0.09741796553134918, -0.01648729480803013, -0.05192543938755989, -0.08041699230670929, 0.05348314717411995, -0.0794709324836731, 0.1041683480143547, -0.0010058763436973095, 0.06904114037752151, 0.005002064164727926, 0.023068059235811234, 0.029651327058672905, 0.01625082455575466, 0.018644869327545166, -0.12245774269104004, -0.041823480278253555, 0.07411743700504303, 0.01268780417740345, 0.020758749917149544, -0.024167992174625397, 0.012817678041756153, -0.008242876268923283, 0.012403199449181557, 0.0544557087123394, 0.00646284269168973, 0.07177206128835678, 0.03214457258582115, -0.03931155055761337, -0.043051883578300476, -0.07463954389095306, -0.06494826078414917, -0.005017127841711044, 0.02194511890411377, 0.04621037840843201, 0.020634949207305908, -0.06911872327327728, -0.005413363687694073, 0.020413778722286224, 0.020298706367611885, 0.03454751893877983, -0.06856009364128113, -0.0487724170088768, -0.08778316527605057, -0.031006021425127983, 0.01980454847216606, 0.07393519580364227, 0.0420556403696537, 0.11583629250526428, -0.07614745199680328, -0.07756131142377853, -0.05147594213485718, 0.012176305055618286, -0.045837149024009705, 0.03091423213481903, 0.03336118161678314, -0.04566149786114693, -0.12943430244922638, 0.06202225759625435, -0.052622903138399124, 0.042225416749715805, -0.014117415994405746, -0.004502193070948124, -0.029829053208231926, -0.07396551966667175, -0.022010648623108864, 0.06116694211959839, 0.021295495331287384, -0.03046538680791855, -0.04120814427733421, 0.060743022710084915, 0.06934323161840439, 0.04971736669540405, 0.07553841173648834, 0.004428267013281584, 0.06735125184059143, 0.07974829524755478, 0.09950729459524155, 0.09864405542612076, -5.437338401748093e-8, -0.006554447580128908, -0.0933438241481781, -0.023477662354707718, 0.034623973071575165, 0.09069196879863739, -0.028807053342461586, 0.03306709602475166, 0.013726315461099148, 0.004729379899799824, -0.02817394770681858, 0.05213629826903343, 0.08834106475114822, -0.08099132776260376, -0.056152764707803726, 0.08773741871118546, -0.03428660333156586, 0.006753131747245789, 0.07212018221616745, -0.041838422417640686, -0.06315692514181137, -0.010326428338885307, 0.08155983686447144, -0.03868279978632927, -0.007066498044878244, -0.012376883998513222, 0.01954275369644165, -0.040725819766521454, -0.01197504810988903, 0.05147719010710716, 0.05316139757633209, 0.060159824788570404, -0.05127860605716705, -0.020844368264079094, -0.029269928112626076, 0.00597219355404377, 0.04826010763645172, -0.08671620488166809, -0.02984919771552086, -0.03185904026031494, 0.12098637223243713, -0.027783486992120743, -0.027548110112547874, -0.028654919937253, 0.08639545738697052, 0.04323715344071388, -0.042045269161462784, -0.08373519033193588, 0.09881920367479324, 0.0008732943679206073, -0.04370000213384628, -0.0069526489824056625, 0.06530589610338211, 0.036158960312604904, -0.030174920335412025, -0.023237207904458046, -0.007753095589578152, 0.06434445083141327, -0.009992288425564766, 0.04909249395132065, 0.042007096111774445, 0.05179852619767189, 0.08105523139238358, 0.0641857162117958, -0.02143336646258831 ]
iron\tsupplements\tare\tdiscussed\tin\t\nTable\t31.3\n.\nTABLE\t31.3\nForms\tof\tIron\tSupplements\nIron\tSupplement\nAdvantages\nDisadvantages\nFerrous\tsulfate\nMost\tcommonly\tstudied\nLeast\texpensive\nMost\tconstipating\nFerrous\tgluconate\nGenerally\twell\ttolerated\twith\nfew\tgastrointestinal\tside\neffects\nCarbonyl\tiron\t(slow\tiron)\nGenerally\twell\ttolerated\twith
[ -0.010333011858165264, -0.09681373834609985, 0.021206839010119438, 0.08489187806844711, -0.040568575263023376, 0.026022575795650482, 0.07227471470832825, 0.006405618507415056, -0.08604540675878525, 0.04939470440149307, 0.025625722482800484, -0.0000797856118879281, 0.002007139613851905, 0.008628311567008495, -0.052977364510297775, -0.05091695860028267, 0.06477205455303192, -0.005117554683238268, -0.04296913743019104, 0.027535121887922287, 0.01210763305425644, 0.036514103412628174, 0.07608255743980408, -0.004863530397415161, -0.005292292218655348, 0.04861655458807945, -0.055480875074863434, -0.014547702856361866, -0.011302953585982323, -0.05721335858106613, -0.1106792613863945, 0.03302847594022751, 0.044136445969343185, -0.042355794459581375, 0.03614604100584984, -0.004279867745935917, -0.019681351259350777, -0.005856812931597233, -0.002826201729476452, 0.01913192681968212, -0.05085388198494911, -0.05290776491165161, -0.006463193334639072, 0.046138279139995575, 0.03728196397423744, -0.0727628692984581, -0.03567960858345032, -0.1059643104672432, -0.013544616289436817, 0.059810273349285126, -0.08529436588287354, -0.033665891736745834, -0.10615236312150955, 0.08747590333223343, 0.06848903745412827, -0.04938313737511635, -0.028665587306022644, -0.06375516206026077, -0.0767897441983223, -0.004543558228760958, -0.02537013217806816, -0.046924129128456116, -0.053495246917009354, -0.008137914352118969, -0.0024833546485751867, 0.10240583121776581, -0.01680794544517994, -0.018382173031568527, -0.006808801554143429, 0.07274936884641647, -0.01437344215810299, 0.036443691700696945, -0.06844821572303772, 0.10070011764764786, 0.022742122411727905, 0.028396470472216606, 0.13113100826740265, -0.08312857151031494, 0.017050668597221375, 0.000319873244734481, -0.11059104651212692, 0.07663010060787201, -0.006457395851612091, 0.041971370577812195, -0.0022527810651808977, 0.0218290314078331, -0.03744640201330185, 0.045132845640182495, -0.020572690293192863, -0.009625297971069813, 0.030650123953819275, -0.03265271335840225, 0.034847162663936615, -0.07782605290412903, -0.001839456264860928, 0.02368924580514431, -0.005303098354488611, -0.07348235696554184, -0.009189778007566929, -0.028678573668003082, -0.011892929673194885, 0.025131888687610626, 0.006184326950460672, 0.02351541444659233, -0.04504818469285965, -0.009685207158327103, 0.02403389848768711, 0.00139757024589926, 0.02546386420726776, 0.02917860448360443, -0.013701745308935642, -0.01353068370372057, 0.02641463465988636, -0.029514309018850327, -0.03281893581151962, -0.03100467287003994, -0.00874167587608099, -0.02062203176319599, 0.12495635449886322, 0.05454638972878456, 0.0378703847527504, -0.01587950438261032, 0.04938586428761482, -0.006984753999859095, -0.04783701151609421, -0.03319459408521652, -0.03092757798731327, 2.9789094985210243e-33, 0.030268942937254906, 0.06272456794977188, 0.033595066517591476, 0.045514874160289764, 0.0018021013820543885, -0.026074379682540894, -0.06634094566106796, -0.053178079426288605, 0.007667612750083208, 0.0737961009144783, -0.09679669886827469, 0.0526268370449543, 0.001182400155812502, 0.08586642146110535, 0.015791606158018112, -0.10477408766746521, -0.023548219352960587, 0.08068067580461502, 0.007363710552453995, -0.01915556937456131, -0.008959216997027397, 0.10557618737220764, 0.051231179386377335, -0.038198571652173996, -0.015050878748297691, -0.02154199592769146, -0.07175949215888977, 0.00637201638892293, -0.04727805405855179, 0.004418402910232544, 0.010608705691993237, -0.04822830110788345, -0.037277474999427795, -0.025044187903404236, -0.03447559475898743, -0.026638008654117584, -0.05880468338727951, 0.0012374453945085406, 0.06340432167053223, -0.028471749275922775, -0.02157546952366829, 0.07146505266427994, -0.0035327989608049393, 0.07574080675840378, 0.056149840354919434, -0.044372085481882095, -0.016594234853982925, 0.024127556011080742, -0.01104852743446827, -0.013735068030655384, -0.005776801146566868, 0.009261471219360828, 0.0701209232211113, -0.036069728434085846, -0.05197135731577873, 0.0288483127951622, 0.006655173376202583, 0.060447826981544495, -0.041800856590270996, 0.1424764096736908, 0.01799853891134262, 0.0746285617351532, 0.046395059674978256, -0.05623053014278412, 0.016019975766539574, 0.02451799437403679, -0.18468491733074188, -0.020904425531625748, 0.017116041854023933, 0.02343073859810829, -0.059492699801921844, 0.004584284964948893, 0.02472740225493908, 0.014611953869462013, 0.08819721639156342, -0.0040199048817157745, -0.0016198705416172743, -0.11540921032428741, -0.004240462090820074, -0.0630665272474289, -0.05019896477460861, -0.07470516115427017, -0.036271873861551285, 0.0043086158111691475, -0.08772353827953339, -0.00207123882137239, 0.0005586608895100653, -0.07224050909280777, 0.049752190709114075, -0.055925965309143066, -0.016215793788433075, 0.03477604687213898, 0.005204005632549524, -0.09687867015600204, -0.11078675091266632, -4.3194278278354065e-33, -0.07463841140270233, 0.0017806637333706021, -0.010126163251698017, 0.04278375953435898, -0.030778132379055023, -0.00020295118156354874, -0.008847353979945183, -0.033142007887363434, 0.07158000767230988, 0.009689358994364738, 0.10366080701351166, 0.0736224576830864, -0.04299217835068703, -0.16935518383979797, -0.06636009365320206, 0.09104803949594498, -0.041448406875133514, 0.07663767784833908, 0.05977815017104149, -0.02460632100701332, -0.022932514548301697, 0.05082504823803902, -0.09970231354236603, 0.01908242329955101, 0.022434091195464134, 0.06830915063619614, -0.047350574284791946, -0.05941884219646454, 0.0822293758392334, 0.05930263176560402, 0.024372410029172897, -0.03098876215517521, 0.018871720880270004, 0.021411055698990822, 0.015587642788887024, -0.016836687922477722, -0.006982002407312393, -0.01977052539587021, -0.06311685591936111, -0.0033718934282660484, 0.03604377806186676, 0.007471795193850994, 0.07241827249526978, 0.08305471390485764, 0.05194228142499924, -0.0374751053750515, -0.07747955620288849, -0.05661223083734512, -0.003906621597707272, 0.09230351448059082, 0.05698150396347046, -0.01561598852276802, -0.057400479912757874, 0.05327668786048889, 0.018270863220095634, 0.0018689302960410714, 0.019136210903525352, -0.048612430691719055, -0.0003302184632048011, 0.004148874897509813, -0.046484142541885376, 0.023658689111471176, 0.07492353022098541, 0.0030048112384974957, 0.08230552077293396, -0.0737166628241539, -0.06315100193023682, -0.04575665295124054, -0.018641063943505287, -0.04926365241408348, -0.008811508305370808, 0.02493203803896904, -0.01325956266373396, -0.1582053154706955, 0.06250423938035965, -0.025893304497003555, 0.07861418277025223, -0.0015140053583309054, -0.07214556634426117, 0.013967792503535748, -0.024163657799363136, -0.0035184354055672884, 0.005945014301687479, 0.010304022580385208, -0.048789169639348984, -0.002730380045250058, -0.023414915427565575, 0.00658862479031086, 0.011678793467581272, 0.045730818063020706, -0.019130609929561615, -0.005018109921365976, 0.01877766288816929, 0.05072702839970589, 0.028234675526618958, -4.721926671891197e-8, 0.024844175204634666, -0.026243962347507477, -0.0017576375976204872, 0.006333401892334223, 0.0032209225464612246, -0.04059644788503647, -0.00039241742342710495, 0.03337915241718292, -0.03270778805017471, -0.005790214519947767, 0.04740475118160248, 0.11936482042074203, -0.04418230056762695, -0.022956356406211853, 0.06069520115852356, 0.025865396484732628, -0.0011216638376936316, 0.10813653469085693, -0.03247738629579544, -0.023812448605895042, 0.008754820562899113, 0.0450521744787693, -0.005551143549382687, 0.0054561379365623, -0.05237656086683273, -0.034616030752658844, -0.029267389327287674, -0.02978689968585968, 0.034272294491529465, 0.07182153314352036, 0.054669804871082306, -0.024745207279920578, 0.00503821624442935, -0.03203659504652023, -0.015402328222990036, 0.013327515684068203, -0.044969405978918076, -0.006361452862620354, -0.040350597351789474, 0.12075453251600266, -0.045063599944114685, -0.025334281846880913, -0.05855072662234306, 0.07956850528717041, 0.0680023580789566, -0.06216686591506004, -0.09914488345384598, 0.0664442926645279, 0.019750971347093582, -0.05300792306661606, -0.0024372816551476717, 0.08530782163143158, 0.022942733019590378, -0.05873916670680046, -0.04406183958053589, 0.11968230456113815, 0.0494731068611145, 0.004088155459612608, 0.005927585065364838, 0.01801227405667305, 0.08682525157928467, 0.0218936987221241, 0.07369860261678696, -0.030985556542873383 ]
effects\nCarbonyl\tiron\t(slow\tiron)\nGenerally\twell\ttolerated\twith\nfew\tgastrointestinal\tside\neffects\nSlow\trate\tof\tsolubilization,\nwhich\tslows\tthe\trate\tof\nabsorption\nChelated\tiron\t(ferrous\tfumarate,\nsuccinate,\taspartate,\tand\tbis\nglycinate)\nBetter\tabsorbed\nFewer\tside\teffects\nLeast\tconstipating\nMore\texpensive
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