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© Binary option training Binary Option | Binary option training Best binary options. | 2019-04-18T18:21:17Z | null | 1,165.8 | 822 | null | 0.445255 | [
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Organisations need to adopt a principles-primarily based approach to resolution-making in the event that they want to apply and develop moral values. So neglect concerning the guidelines ask yourself what the intention behind the rule was. Our present focus is on undergraduate and graduate students in the Albers School of Business and Economics.
People — together with, importantly, the university’s professors — cannot quite belief McGill the best way they used to. And that loss sits not with a single professor who wrote one thing rash, but with the academic leaders who sought to protect the university’s identify within the brief run, without adequate regard for what that might imply to the brand, within the longer run.
This means challenging assumptions, particular person values and priorities, and exploring common targets to carry the organisation’s values to life. The data relating to the financial performance of the company performs an essential role in enabling folks to take right resolution about the company. | 2019-04-19T17:15:23Z | null | 385.9 | 1,029 | null | 0 | [] | [] | true | [] |
After going to an individual team page how do I get back to the homepage?
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Same staff member listed multiple times.
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Why will my calendar not import from Google/Yahoo etc? | 2019-04-22T22:30:52Z | null | 694.5 | 4,706 | null | 0 | [] | [] | true | [] |
Long overdue, and good for him. Mattis is another one, like Nikki Haley, who may escape the hapless Trump administration with an intact measure of integrity and dignity. You can’t work for a con man and a grifter, someone who doesn’t read or think deeply and who acts impulsively on outdated and misguided instincts, without eventually getting caught up in the muck and the incompetence.
Mattis’ departure is not so good for the country. Both CNN and MSNBC were in hair on fire mode. Quite rightly, I’d say.
No wonder Trump’s parents sent him to military school. He’s like living with a tornado. Pretty tiresome, actually. | 2019-04-20T09:12:37Z | null | 261.3 | 622 | null | 0 | [] | [] | true | [] |
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Caliciviruses in the genus Sapovirus are a significant cause of viral gastroenteritis in humans and animals. However, the mechanism of their entry into cells is not well characterized. Here, we determined the entry mechanism of porcine sapovirus (PSaV) strain Cowden into permissive LLC-PK cells. The inhibition of clathrin-mediated endocytosis using chlorpromazine, siRNAs, and a dominant negative (DN) mutant blocked entry and infection of PSaV Cowden strain, confirming a role for clathrin-mediated internalization. Entry and infection were also inhibited by the cholesterol-sequestering drug methyl-β-cyclodextrin and was restored by the addition of soluble cholesterol, indicating that cholesterol also contributes to entry and infection of this strain. Furthermore, the inhibition of dynamin GTPase activity by dynasore, siRNA depletion of dynamin II, or overexpression of a DN mutant of dynamin II reduced the entry and infection, suggesting that dynamin mediates the fission and detachment of clathrin- and cholesterol-pits for entry of this strain. In contrast, the inhibition of caveolae-mediated endocytosis using nystatin, siRNAs, or a DN mutant had no inhibitory effect on entry and infection of this strain. It was further determined that cell entry of PSaV Cowden strain required actin rearrangements for vesicle internalization, endosomal trafficking from early to late endosomes through microtubules, and late endosomal acidification for uncoating. We conclude that PSaV strain Cowden is internalized into LLC-PK cells by clathrin- and cholesterol-mediated endocytosis that requires dynamin II and actin rearrangement, and that the uncoating occurs in the acidified late endosomes after trafficking from the early endosomes through microtubules.
Viruses are obligatory intracellular parasites, and so must deliver their genetic material into host cells to initiate infection. This requires the specific recognition of cell surface molecules and the subsequent entry process . The mechanisms by which viruses gain entry into host cells are diverse and include direct penetration through the plasma membrane or endocytic uptake followed by vesicular transport through the cytoplasm and delivery to endosomes and other intracellular organelles . The internalization process can occur via clathrin-mediated endocytosis, caveolar/lipid raft-mediated endocytosis, macropinocytosis, or a variety of other still poorly characterized mechanisms .
Clathrin-mediated endocytosis is generally accepted to be a major route by which nonenveloped viruses infect cells . This route is utilized by a variety of viruses, such as adenovirus , canine parvovirus , and picornaviruses including rhinovirus and foot-and-mouth disease virus . In many cases and even within the same family, viruses utilize different endocytic pathways. As examples, parechovirus 1 and coxsackievirus B3 (CVB3) use caveolae to infect cells [7, 8], while human echovirus 11 and CVB4 enter cells in a cholesterol-dependent manner [9, 10]. Furthermore, adeno-associated virus type 5, Japanese encephalitis virus, and influenza virus use more than one entry mechanism [11–13].
Caliciviruses are small, nonenveloped viruses of 27–35 nm in diameter, which enclose a single-stranded, positive sense RNA of 7–8 kb . Caliciviruses have been formally classified into five genera: Norovirus, Sapovirus, Vesivirus, Lagovirus, and Nebovirus . In addition, six new genera named Recovirus , Bavovirus [16, 17], Nacovirus [17–19], Salovirus , Sanovirus , and Valovirus have been proposed. Sapoviruses (SaVs) and noroviruses are important etiologic agents of both human and animal viral gastroenteritis. Due to low propensity of enteric caliciviruses to grow in vitro, there is still limited understanding of their biology. Porcine sapovirus (PSaV) Cowden strain, a genogroup III SaV, is the only strain within the Sapovirus genus that replicates efficiently in vitro .
Caliciviruses vary in their mechanisms used for cell entry and replication. For example, feline calicivirus (FCV) uses clathrin-mediated endocytosis for cell entry , whereas murine norovirus-1 (MNV-1) uses dynamin and cholesterol-linked pathways [25, 26]. Following entry, the events that facilitate release of the calicivirus positive-sense RNA genome into the cytoplasm remain unclear. FCV replication is sensitive to chloroquine-mediated inhibition of vesicular-acidification, suggesting that release of the viral RNA into the cytoplasm requires a low pH environment . In addition, FCV binding to the cellular receptor JAM-1 induces a conformational change in the capsid, indicating that uncoating may, in part, be receptor-binding mediated . In contrast, MNV-1 infectivity does not depend on the acidification of endosomes [25, 28].
We have recently demonstrated that bile acids, endosomal acidification, and cathepsin L activity are required for PSaV uncoating and genome release into the cytoplasm [29, 30]. However, the detailed mechanism of PSaV entry into the host cells is yet to be determined. In the current study, we examined the entry process of PSaV using the cultivable Cowden strain as a model system. We demonstrate that the PSaV Cowden strain enters the permissive porcine kidney LLC-PK cells via clathrin- and cholesterol-dependent endocytic pathways, in a process that requires both dynamin II and actin for vesicle internalization. We further demonstrate that PSaV Cowden strain requires the Ras-related protein 5 (Rab5) and Rab7 GTPases to deliver virus cargo from the early endosomes (EEs) to the late endosomes (LEs) via microtubules, and that late endosomal acidification is essential for virus uncoating. These findings represent new insights into PSaV Cowden strain cell entry process.
Porcine kidney LLC-PK and human cervical cancer HeLa cells obtained from the American Type Culture Collection (ATCC, Manassas, VA, USA) were maintained in Eagle’s minimal essential medium (EMEM). Human intestinal Caco-2 cells (ATCC) were grown in Dulbecco’s modified Eagle’s medium (DMEM). Monkey kidney MA104 cells (ATCC) were grown in alpha minimal essential medium (α-MEM). Each culture medium was supplemented with 10% fetal bovine serum (FBS), 100 U/mL penicillin, and 100 µg/mL streptomycin. The PSaV Cowden strain was generated from the full-length infectious clone pCV4A and was propagated in LLC-PK cells in the presence of 200 μM GCDCA . CVB3 Nancy strain (ATCC) was propagated in HeLa cells and then used for the subsequent studies with Caco-2 cells . The human rotavirus strain Wa (G1P ) (ATCC) was preactivated with 10 μg/mL crystalized trypsin and propagated in MA104 cells as previously described .
Chlorpromazine, chloroquine, and GCDCA purchased from Sigma-Aldrich (St. Louis, MO, USA) were dissolved in distilled water (DDW). Nystatin, methyl-beta-cyclodextrin (MβCD), cytochalasin D, nocodazole, and amiloride (Sigma-Aldrich) were dissolved in dimethyl sulfoxide (DMSO). Alexa Fluor 594 (AF594) succinimidyl ester purchased from Molecular Probes (Eugene, OR, USA) was dissolved in DMSO. AF488-labeled phalloidin, 5-chloromethylfluorescein diacetate (CMFDA) pH probe, and slowFade Gold antifade reagent with 4′,6-diamidino-2-phenylindole (DAPI) were obtained from Molecular Probes (Eugene, OR, USA). Mouse monoclonal antibodies (Mabs) against each clathrin heavy chain, caveolin-1, and early endosome antigen 1 (EEA1) were purchased from BD Transduction Laboratories (Lexington, KY, USA). Rabbit anti-dynamin 2 and rabbit anti-Rab7 polyclonal antibodies, and mouse anti- lysosome-associated membrane protein-2 (LAMP2) Mab were purchased from Abcam (Cambridge, MA, USA). Rabbit anti-Rab5 polyclonal antibody was obtained from Cell Signaling Technology (Beverly, MA, USA). Rabbit anti-glyceraldehyde 3-phosphate dehydrogenase (GAPDH, FL-335) polyclonal antibody was from Santa Cruz Biotechnology (Dallas, TX, USA). Rabbit anti-PSaV VPg polyclonal antibody , mouse anti-CVB3 capsid Mab (Millipore, Bedford, MA, USA), and mouse anti-rotavirus VP6 Mab (Median Diagnostic, Chuncheon, South Korea) were used to detect the corresponding viruses. Secondary antibodies included horseradish peroxidase (HRP)-conjugated goat anti-rabbit IgG (Cell Signaling Technology), HRP-conjugated goat anti-mouse IgG (Ab Frontier, Seoul, South Korea), fluorescein isothiocyanate (FITC)-conjugated anti-rabbit IgG, and FITC-conjugated anti-mouse IgG antibodies (Santa Cruz Biotechnology) were used.
The cytotoxicity of the chemicals used in this study was determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay as described elsewhere . Briefly, confluent LLC-PK, Caco-2, and MA104 cells grown in 96 wells were incubated with medium containing different concentrations of inhibitors for 24 h. After removal of the media, 200 μL of MTT solution was transferred to each well and incubated for 4 h at 37 °C in a CO2 incubator. Afterward, 150 μL DMSO was added to each well and incubated at room temperature for 10 min. The absorbance was read in an ELISA reader with the optical density (OD) value of 570 nm. The percentage of cell viability was calculated as: [OD(sample) − OD(blank)/(OD(control) − OD(blank)] × 100. Non-toxic concentrations of each chemical were used in this study.
AF594 labeling of PSaV particles purified by cesium chloride (CsCl) density-gradient centrifugation was performed as described elsewhere . Briefly, purified PSaV particles (10 mg at 1 mg/mL) in 0.1 M sodium bicarbonate buffer (pH 8.3) was mixed with one tenth fold-molar concentration of AF594 succinimidyl ester (1 mg at 1 mg/mL in DMSO) by vortexing for 30 s. The mixture was incubated for 1 h at room temperature with continuous stirring. Labeled PSaV particles were repurified with CsCl density-gradient centrifugation, dialyzed against virion buffer, and stored in aliquots of 2 µg at −20 °C. The AF594-labeled virus particles were counted along with the latex beads (Sigma-Aldrich) in at least 10 randomly chosen squares on the grid. The total virus count was calculated by the ratio of the virus particle number to the latex particle number and multiplied by the known latex particle concentration per mL.
Cells grown in 12-well plates or 8-well chamber slides to the desired confluency were washed twice with phosphate-buffered saline (PBS, pH 7.2). Subsequently, the cells were pretreated with various non-toxic working concentrations of the chemicals (Table 1) for 1 h at 37 °C. After washing the cells twice with PBS, the cells were infected with AF594-labeled or mock-labeled virus for the indicated times. Internalization, infectivity, NR infectious center assays were carried out as described below. Mock and control treatments were performed simultaneously.
DW, distilled water; DMSO, dimethyl sulfoxide.
siRNAs targeting clathrin heavy chain, dynamin II, caveolin-1, Rab5, and Rab7, or scrambled siRNA were purchased from Santa Cruz Biotechnology (Additional file 1) [35–40]. Rab5 and Rab7 siRNAs were used at 20 nM concentration. Other siRNAs were used at 100 nM. Plasmid constructs of green fluorescent protein (GFP)-tagged-wild type (WT) and DN Eps15 were kindly provided by Alice Dautry-Vautry (Pasteur Institute, Paris, France) . GFP-tagged WT and K44A DN dynamin II were kindly provided by Mark McNiven (Mayo Institute, Rochester, MS, USA) . GFP-tagged WT and DN caveolin were kindly provided by Ari Helenius (Swiss Federal Institute of Technology, Zurich) . Transfection of siRNAs or plasmids was performed using Lipofectamine 2000 (Invitrogen, Carlsbad, CA, USA) according to the manufacturer’s instructions . To ensure effective siRNA knockdown of each target protein, transfected cells harvested at 24 h or 48 h post-transfection were analyzed by Western blotting analysis.
Mock-, chemical-treated, or siRNAs-transfected LLC-PK cells in 8-well chamber slides were inoculated with AF594-labeled PSaV Cowden strain (approximately 415 particles per cell) for 30 min at 4 °C. The cells were then shifted to 37 °C for the indicated times to allow virus entry to proceed. The cells were then fixed with 4% paraformaldehyde in PBS for 15 min at 20 °C and incubated with AF488-labeled phalloidin (10 units) for 15 min at 20 °C for cytoskeleton staining. For colocalization with endosomal markers, the cells were then permeabilized by the addition of 0.2% Triton X-100 in PBS for 10 min at 20 °C and washed with PBS containing 0.1% new-born calf serum (PBS-NCS). The cells were then incubated with Mabs against EEA1 and LAMP2 (1:100 dilution) at 4 °C overnight, washed twice with PBS-NCS, and incubated with FITC-conjugated anti-mouse IgG antibody (1:100 dilution) for 1 h at room temperature. The cells were mounted with SlowFade Gold antifade reagent containing 1 × DAPI solution for nucleus staining. Infected cells were observed with a LSM 510 confocal microscope and analyzed using LSM software (Carl Zeiss, Jena, Germany).
The low-pH rescue experiment was performed as described previously . Briefly, mock- or chloroquine-treated LLC-PK cells infected with AF594-labeled PSaV particles (approximately 415 particles per cell) were incubated with either neutral (pH 7.2) or acidic (pH 5) citrate buffers for 5 min at 37 °C. After washing three times with PBS, the cells were incubated with EMEM with 2.5% FBS and 100 μM GCDCA for 2 h at 37 °C. Subsequently, the infected cells were fixed, permeabilized and stained with anti-LAMP2 antibody as described above.
The cell tracker green CMFDA pH probe was used to visualize intracellular acidic compartments as described elsewhere [40, 45]. Briefly, LLC-PK cells treated with or without chloroquine or infected with or without PSaV Cowden strain were washed with PBS and were incubated with CMFDA working solution (10 μM) for 30 min at 37 °C, which was then replaced with maintenance medium and incubated for another 30 min at 37 °C. Fixation and permeabilization were then performed as described above. To check the colocalization with late endosome marker, the cells were incubated with anti-LAMP2 antibody and examined by confocal microscope as described above.
Infectivity assays were carried out as previously described . Briefly, confluent monolayers of cells in 8-well chamber slides, which were not pretreated or pretreated with chemicals, or which were transfected with or without siRNAs, WT, or DN plasmids, were uninfected or infected with each virus. Virus inocula were then removed and cells were washed twice with PBS. Cells were incubated with PSaV Cowden strain for 24 or 36 h, with CVB3 Nancy strain for 4 h or 6 h, or with rotavirus Wa strain for 8 h or 15 h. The cells were then fixed with 4% paraformaldehyde in PBS for 15 min at room temperature, permeabilized by the addition of 0.2% Triton X–100 for 10 min at room temperature, and washed three times with PBS containing 0.1% PBS-NCS. The chamber slides were then incubated with primary antibodies (anti-PSaV VPg, anti-CVB3 capsid, or anti-RVA VP6) at 4 °C overnight. Subsequently, cells were washed three times with PBS, and FITC-conjugated secondary antibodies were added. After washing with PBS-NCS, the nuclei were stained with DAPI, and cells were examined using confocal microscopy. The number of infected cells was checked in 500 cells . After image analysis with Zeiss LSM image browser (Oberkochen, Germany), the infected cells were counted as positive for viral antigen if they had a fluorescent intensity at least three times that of the uninfected controls. The percentage of positive cells was then normalized to that of the untreated control.
NR-labeled PSaV particles were produced as described elsewhere [31, 47]. Briefly, LLC-PK cells were infected with the PSaV Cowden strain [multiplicity of infection (MOI) of 1 focus forming units (FFU)/cell] in 10 μg/mL NR. After incubation for 72 h, NR-labeled PSaV were harvested and purified in the dark. The NR infectious center assay was performed as previously described [31, 47]. Briefly, confluent monolayers of LLC-PK cells grown in 6-well plates were pretreated with chemicals or transfected with siRNAs. The cells were then infected with NR-PSaV for the indicated times at 37 °C in the dark and then exposed to ultraviolet (UV) light at 120 mJ/cm2 at 20 °C. Duplicate monolayers were maintained in the dark and used as unilluminated controls. The cells were detached with trypsin–EDTA, and the dissociated cells were counted, diluted, and replated onto fresh LLC-PK monolayers in 6-well plates. Each well was overlaid with agarose at 3 h post-infection. After 4 days, plaques that had developed were counted. In each of three independent experiments, the numbers of plaques in the chemical-treated or illuminated wells were normalized to the number of plaques in the unilluminated control (expressed as a percentage).
Confluent LLC-PK cells in 6-well plates infected with or without PSaV Cowden strain, or transfected with or without siRNAs were harvested. The cells were washed twice with PBS and lysed with a cell extraction buffer (Invitrogen) supplemented with protease and phosphatase inhibitors (Roche, Basel, Switzerland). After centrifugation at 12 000 × g for 10 min at 4 °C, the supernatants of the cell lysates were normalized for equal protein content using a BCA protein assay kit (Thermo Scientific, Waltham, MA, USA). Total cell lysates were denatured and resolved by sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS-PAGE). The resolved proteins were transferred to nitrocellulose blotting membranes (Amersham Protran; GE Healthcare Life Science, Little Chalfont, UK) and immunoblotted with primary antibodies specific for each target protein as described above. After incubation with secondary antibodies against mouse or rabbit IgG, immunoreactive bands were developed using an enhanced chemiluminescence reaction kit (DoGen, Seoul, South Korea), and images were obtained using the Davinch–Western imaging system (Young Ltd., Seoul, South Korea).
LLC-PK cells in 12-well plates transfected with or without siRNAs were infected with PSaV Cowden strain (MOI of 1) for 36 h at 37 °C. Virus titers were determined at 6 days post-infection using the TCID50 assay as previously described , and TCID50/mL was calculated using the method of Reed and Muench .
Statistical analyses were performed on triplicate experiments using GraphPad Prism 5 software version 5.03 (GraphPad Software, Inc., La Jolla, CA, USA) and a one-way ANOVA test. A P value of less than 0.05 was considered statistically significant. Figures were generated using Adobe Photoshop CS3 (Adobe Systems, San Jose, CA, USA) and the aforementioned Prism 5 version 5.03 software.
To examine the cellular factors required for PSaV entry into cells, we used pharmacological inhibitors after confirming their cytotoxicity (Additional files 2, 3, 4), siRNAs against clathrin heavy chain, dynamin II, and caveolin-1, and dominant negative (DN) mutants targeting clathrin- and non-clathrin-mediated endocytosis. PSaV infection was significantly inhibited by chlorpromazine (Figure 1), an inhibitor of clathrin-mediated endocytosis , by siRNA depletion of clathrin (Figure 2), and by a DN mutant of the clathrin adaptor protein Eps15 (Figure 3). PSaV infection was also markedly inhibited by dynasore (Figure 1), a pharmacological inhibitor of dynamin GTPase activity , by siRNA depletion of dynamin II (Figure 2), and by a DN mutant of dynamin II (Figure 3). In addition, methyl-beta cyclodextrin (MβCD), a pharmacological inhibitor of cholesterol-mediated endocytosis , also had a marked inhibitory effect on PSaV infection, but this inhibitory effect was restored by addition of soluble cholesterol (Figure 1). In contrast, treatment with nystatin, which disrupts caveolae-mediated endocytosis, depletion of caveolin-1 by siRNA, or transfection of a DN mutant for caveolin-1 had no effect on PSaV infection (Figures 1, 2, 3). However, infection of Caco-2 cells by the control CVB3 Nancy strain, which is cholesterol- and caveola/lipid raft-dependent was inhibited by MβCD and nystatin (Figure 1), by depletion of caveolin-1 using siRNAs (Figure 2), and by the use of a DN mutant of caveolin-1 (Figure 3). Similarly, infection of cells with the human rotavirus Wa strain, which uses a clathrin-, cholesterol-, and dynamin-dependent entry process [51, 52], was significantly inhibited by chlorpromazine, MβCD, and dynasore (Figure 1), by siRNA depletion of clathrin or dynamin (Figure 2), as well as by DN mutants of the clathrin adaptor protein Eps15 and dynamin II (Figure 3). These results indicate that infection of permissive LLC-PK cells by the PSaV Cowden strain requires clathrin, cholesterol, and dynamin II.
Chemical inhibitors against clathrin-, dynamin-, and cholesterol-mediated endocytosis reduce PSaV infection. A–C Confluent monolayers of LLC-PK, Caco-2, and MA104 cells were treated with DMSO vehicle or different concentrations of chlorpromazine (CPZ), MβCD, nystatin, or dynasore prior to infection with PSaV Cowden (A), Coxsackievirus B3 (CVB3) Nancy (B), or human rotavirus Wa (C) strains. Soluble cholesterol was added to the medium to examine the effect of cholesterol replenishment following MβCD-mediated depletion and then cells were infected with PSaV Cowden, CVB3 Nancy, or human rotavirus Wa strains. Infected cells were counted after staining with antibodies specific for each virus, and nuclei were counted after staining with DAPI. For each virus, results are shown as the percentage of infected cells, and normalized to the result obtained with control DMSO-treated cells. Data for panels A–C are presented as mean ± standard deviation of the mean from three independent experiments. Differences were evaluated using one-way ANOVA. *P < 0.05; **P < 0.001; ***P < 0.0001.
Small interfering RNAs (siRNAs) against clathrin- and dynamin-mediated endocytosis reduce PSaV infection. A LLC-PK cells transfected with scrambled siRNA (Scram) or siRNAs against clathrin heavy chain (CHC), dynamin II, or caveolin-1 were harvested at 24 and 48 h post-transfection. The down-regulation of each protein by siRNA knock-down was evaluated by western blotting analysis using antibodies specific for each protein. The intensity of each target protein relative to GAPDH was determined by densitometric analysis and is indicated above each lane. The cells transfected with each siRNA and then incubated were infected with PSaV Cowden (B), CVB3 Nancy (C), or rotavirus Wa (D) strains. Infected cells were counted after staining with antibodies specific for each virus, and nuclei were counted after staining with DAPI. For each virus, results are shown as the percentage of infected cells, and normalized to the results obtained in the scrambled siRNA-transfected cells. Data for panels B–D are presented as mean ± standard deviation of the mean from three independent experiments. Differences were evaluated using one-way ANOVA. *P < 0.05; **P < 0.001; ***P < 0.0001.
Dominant negative (DN) mutants against clathrin- and dynamin-mediated endocytosis reduce PSaV infection. The cells transfected with GFP-tagged wild type (WT) or dominant negative (DN) Eps15, caveolin-1, or dynamin II were incubated with PSaV Cowden (A), CVB3 Nancy (B), or rotavirus Wa (C) strains. Infected GFP-expressing cells were counted after being stained with antibodies specific for each virus. Data for panels A–C are presented as mean ± standard deviation of the mean from three independent experiments. Differences were evaluated using one-way ANOVA. *P < 0.05; **P < 0.001; ***P < 0.0001.
To gain a better understating of the kinetics of PSaV entry and uncoating into permissive LLC-PK cells, we used a NR infectious center assay as previously described [31, 47]. The RNA-binding NR dye is passively incorporated into the viral RNA during viral propagation, resulting in light-sensitive NR-containing virions. Upon UV illumination, the dye is activated, damaging the viral RNA, and inactivating the virus infectivity [31, 47]. However, after virus entry, uncoating, and release of the viral genome into the cytoplasm, the NR dissociates from the viral RNA genomes, which thereby become light insensitive [31, 47]. NR-labeled MNV has previously been used to study virus entry, highlighting the utility of NR in the study of calicivirus entry . As shown in Figure 4A, NR-labeled PSaV Cowden strain was sensitive to light exposure from 45 min post-infection (mpi), but the majority of the strain became insensitive to light from 90 mpi. This agrees with our previous finding that uncoating and genome release of PSaV Cowden strain take place within 90 mpi [29, 30].
PSaV entry and RNA release depend on clathrin-, dynamin-, and cholesterol-mediated endocytosis. A LLC-PK cells grown in 6-well plates were incubated with neutral red (NR)-labeled PSaV Cowden strain for the indicated times and then exposed or not to UV light. The supernatants of each cell lysate were inoculated into fresh LLC-PK monolayers in 6-well plates, overlaid with agar, and incubated for 4 days. Results are shown as percentages to the number of plaques in the unilluminated control. The NR infectious center assay was performed in cells pretreated with DMSO vehicle or 20 μM chlorpromazine (CPZ), or transfected with scrambled siRNA or CHC siRNA (B); pretreated with DMSO vehicle or 100 μM dynasore (Dyna), or transfected with scrambled siRNA or dynamin II (Dyn II) siRNA (C); or pretreated with DMSO vehicle, 20 mM MβCD for 1 h, or MβCD followed by incubation with 200 μM soluble cholesterol for 30 min (D). The cells were then incubated with NR-labeled PSaV for 120 min. The number of plaques was normalized to those obtained with unilluminated controls exposed to the above conditions. Data for panels A–D are presented as mean ± standard deviation of the mean from three independent experiments. Differences were evaluated using one-way ANOVA. *P < 0.05; **P < 0.001; ***P < 0.0001.
Using the NR-containing PSaV Cowden strain, we further examined the specific role of clathrin, dynamin, and cholesterol in PSaV uncoating and genome release. Treatment with DMSO vehicle alone prior to infection of PSaV Cowden strain had no inhibitory effect on PSaV-induced infectious center formation at 120 mpi regardless of UV illumination (Figures 4B–D). However, light exposure at 120 mpi significantly reduced PSaV-induced infectious center formation after pretreatment with chlorpromazine, dynasore, and MβCD, and after siRNA depletion of clathrin and dynamin II in comparison with that of the equivalent unilluminated controls (Figures 4B–D). In addition, supplementation of cholesterol into the medium after MβCD treatment reinstated the infectious center formation by PSaV Cowden strain (Figure 4D). These results confirmed that entry of PSaV Cowden strain depends on clathrin, dynamin, and cholesterol.
We next examined whether clathrin, dynamin, and cholesterol were also necessary for internalization of PSaV Cowden strain. LLC-PK cells were pretreated with vehicle or inhibitors, and the internalization of AF594-labeled PSaV Cowden strain was monitored as described elsewhere [31, 46]. In cells pretreated with either DMSO vehicle or nystatin, AF594-labeled PSaV particles were readily internalized in the cytoplasm (Additional file 5) and were evident around the nucleus (Additional file 5). However, pretreatment of the cells with chlorpromazine, dynasore, or MβCD trapped PSaV particles around the cell surface (Additional file 5). Replenishment of MβCD-treated cells with soluble cholesterol restored the internalization of AF594-labeled PSaV particles, leading to their internalization and accumulation of virus particles in the perinuclear area (Additional file 5). These findings, together with the data presented above, indicate that entry and infection of PSaV Cowden strain require the internalization of virions through both clathrin- and cholesterol-mediated endocytosis, in a process that also requires dynamin II.
We previously demonstrated that LEs are involved in PSaV trafficking [29, 30]. However, the precise mechanism by which PSaV Cowden strain reaches LEs is unclear. We examined the localization of AF594-labeled PSaV Cowden strain during the entry phase by co-staining cells with markers for EEs (EEA1) and LEs (LAMP2). Results showed that AF594-labeled PSaV Cowden strain was found maximally associated with the EE marker EEA1 at 30 mpi, after which the colocalization decreased, as did the signal for AF594-labeled PSaV Cowden strain (Additional file 6). The colocalization of PSaV Cowden strain with the LE marker LAMP2 was maximal at 60 mpi, after which the signal for AF594-labeled virus particles decreased (Additional file 6B), indicating that uncoating and genome release of PSaV Cowden strain had most likely already occurred at 90 mpi. These results further support our previous findings [29, 30] and agree with the results obtained using the NR infectious center assays (Figure 4A), suggesting that PSaV Cowden strain travels from EEs to LEs, and that its viral genome release occurs by 90 mpi.
The Rab GTPases proteins are important regulators of the process of endocytosis including vesicle formation, vesicle movement, and membrane fusion . Among these proteins, Rab5 regulates early endocytic events, while Rab7 is involved in the transition from EEs to LEs and the maturation of LEs . To further define the entry process of PSaV Cowden strain, we examined whether Rab5 and Rab7 are required for virus entry and infection. As expected, AF594-labeled PSaV Cowden strain colocalized with EEA1 at 30 mpi (Figure 5A) and LAMP2 at 60 mpi (Figure 5B) in the perinuclear areas of scrambled siRNA-transfected LLC-PK cells. However, siRNA-mediated silencing of Rab5 or Rab7 trapped AF594-labeled virus particles in the periphery of the cytoplasm and abrogated the colocalization of virus particles with EEA1 or LAMP2, respectively (Figures 5A and B).
PSaV entry depends on Rab5 and Rab7. A, B LLC-PK cells were transfected with scrambled siRNA or siRNAs against Rab5 (A) or Rab7 (B). Next, cells were exposed to AF594-labeled PSaV particles (approximately 415 particles per cell) for EEA1 colocalization or for LAMP2 colocalization. This experiment was done in triplicate and representative images are shown. The scale bars correspond to 10 μm. The bottom portion displays immunoblots to confirm silencing levels of Rab5 and Rab7 by transfection of each corresponding siRNA. The intensity of each target protein relative to GAPDH was determined by densitometric analysis and is indicated above each lane.
siRNA-mediated depletion of either Rab5 or Rab7 significantly reduced the number of virus-infected cells (Figure 6A), production of viral progeny (Figure 6D), and PSaV-VPg expression levels (Figure 6E) in comparison with scrambled siRNA-transfected cells. As shown in Figure 6B, infectivity of the EE-dependent CVB3 Nancy strain was significantly decreased only by Rab5 depletion [31, 54], whereas entry of the LE-dependent rotavirus Wa strain was significantly reduced by siRNA-mediated depletion of both Rab5 and Rab7 (Figure 6C) . Taken together, these results indicate that PSaV Cowden strain travels from EEs to LEs before uncoating occurs.
PSaV infection depends on Rab5 and Rab7. A–D LLC-PK, Caco-2, and MA104 cells were transfected with scrambled siRNA or siRNAs against Rab5 or Rab7, and then incubated with PSaV Cowden (A), CVB3 Nancy (B), or rotavirus Wa (C) strains, respectively. Infected cells were counted after staining with antibodies specific for each virus, and nuclei were counted after staining with DAPI. For each virus, results are shown as the percentage of infected cells, normalized to the results obtained in the scrambled siRNA-transfected cells. D The virus titer was determined by TCID50 using the cell lysates harvested from the cells in the above experimental conditions. Data for panels A–D are presented as mean ± standard deviation of the mean from three independent experiments. Differences were evaluated using the one-way ANOVA. *P < 0.05; **P < 0.001; ***P < 0.0001. E The level of PSaV VPg protein production in the above conditions was determined by western blotting analysis. GAPDH was used as a loading control. The intensity of PSaV VPg protein relative to GAPDH was determined by densitometric analysis and is indicated above its lane.
We have recently shown that PSaV Cowden strain requires acidification of LEs for efficient entry and infection [29, 30]. To explore this in more detail, we examined endosomal acidification after infection of PSaV Cowden strain using the green CMFDA pH probe. As shown in Figure 7A, the intensity of the CMFDA-positive fluorescent signal markedly increased in virus-infected cells, and significantly decreased after pretreatment of cells with chloroquine, an inhibitor of endosomal acidification. Colocalization of the CMFDA-positive structures with LAMP2 was not observed in the control cells but appeared in virus-infected cells (Figure 7B). However, pretreatment of cells with chloroquine markedly decreased the intensity of CMFDA staining, which resulted in reduced colocalization with LAMP2 (Figure 7B). To confirm the above results, we next investigated whether replacement of the culture medium with an acidic buffer in chloroquine-pretreated cells could restore virus release from LEs. As expected, replacement of the culture medium with a neutral buffer still trapped AF594-labeled virus particles in the LEs of chloroquine-pretreated cells even after incubation for 2 h (Figure 7C). Interestingly, acidic replenishment of the culture medium resulted in the disappearance of viral particles from the LEs in chloroquine-pretreated cells (Figure 7D). Furthermore, PSaV-infection was reduced in chloroquine-pretreated cells in a dose-dependent manner (Additional file 7). These data further confirm that entry and infection of PSaV Cowden strain depends on acidification of LEs [29, 30].
PSaV entry is pH-dependent and involves actin and microtubules. A, B Mock- or chloroquine-treated LLC-PK cells were inoculated with the PSaV Cowden strain and then incubated with CMFDA to visualize acidification of intracellular compartments, and incubated for further 30 min in maintenance media (A) or incubated with CMFDA followed by LAMP2 antibody to check colocalization by confocal microscopy (B). C, D After pretreatment of LLC-PK cells with chloroquine and infection with AF594-labeled PSaV particles (approximately 415 particles per cell), cells were incubated with neutral (pH 7.2) (C) or acidic (pH 5.2) buffers (D). The cells were prepared for confocal microscopy to check colocalization of AF594-labeled PSaV particles with LAMP2. All experiments were performed in triplicate and panels A–D show representative sets of results. Scale bars for panels A–D correspond to 10 μm.
We next examined the role of the actin cytoskeleton and microtubules in the vesicular trafficking of PSaV. Treatment with either the actin-polymerizing inhibitor, cytochalasin D, or the microtubule disrupter, nocodazole, reduced the number of PSaV-infected cells in a dose-dependent manner (Additional file 7). These results suggest that actin remodeling and microtubules are required for PSaV entry and infection. In contrast, pretreatment of cells with amiloride, an inhibitor of macropinocytosis, had no inhibitory effect on virus infection, indicating that PSaV Cowden strain does not enter the cells through macropinocytosis (Additional file 7).
To confirm that PSaV Cowden strain does not use caveolin-mediated endocytosis or macropinocytosis as a minor route of entry, we pretreated LLC-PK cells with a mixture of inhibitors. Chlorpromazine was used alone or in combination with nystatin or amiloride. In addition, MβCD was used alone or with nystatin or amiloride. After the pretreatments, the cells were infected with PSaV Cowden strain. Results showed that no significant decrease in PSaV entry was observed in the combined treatments in comparison with the sole use of chlorpromazine or MβCD (Additional file 8), suggesting that caveolin-mediated endocytosis and macropinocytosis did not play a minor role in PSaV infection in LLC-PK cells.
The lack of an efficient cell culture system of human SaVs has hampered the study of the SaV life cycle. PSaV Cowden strain remains the only cultivable member of the genus Sapovirus and thus has been widely used as a model strain [23, 33, 46]. Although receptor-mediated entry of viruses into host cells represents the first step of virus infection, the precise mechanisms utilized by the members of the Sapovirus genus to enter permissive cells have not been defined. Here, we demonstrate that PSaV Cowden strain is internalized into LLC-PK cells via clathrin-, cholesterol-, and dynamin-mediated endocytosis. The entry of PSaV Cowden strain has apparently similar features to those of other members of the Caliciviridae. For instance, the FCV F9 strain in the genus Vesivirus utilizes clathrin-mediated endocytosis , whereas entry of MNV-1 from the Norovirus genus occurs via a cholesterol- and dynamin-dependent pathway .
Dynamin is a large GTPase that is best known for its role in plasma membrane fission and pinching off of endocytic vesicles from the cellular plasma membrane during clathrin-dependent endocytosis [2, 26]. Many viruses, such as vesicular stomatitis virus and classical swine fever virus , enter the cells through a clathrin-dependent pathway in cooperation with dynamin II. Within the Caliciviridae family, FCV uses clathrin-mediated endocytosis but the role of dynamin is unclear . Our results suggest that dynamin mediates the fission and detachment of clathrin-coated pits for entry of PSaV Cowden strain.
Dynamin is also involved in plasma membrane fission and pinching off of endocytic vesicles in caveolin-1- or cholesterol-dependent endocytosis from the cellular plasma membrane [2, 26]. Cholesterol-/dynamin II-dependent endocytosis plays a role in the entry of several viruses, such as MNV-1 , CVB3 , feline infectious peritonitis virus (FIPV) , and the simian rotavirus RRV strain . In addition, a study using the Norwalk replicon system demonstrated the importance of cholesterol in the replication of HuNoV . In the present study, inhibition of the entry and infection of PSaV Cowden strain by the cholesterol-sequestering drug MβCD was restored by the addition of soluble cholesterol. These data indicate that, like MNV-1 , PSaV Cowden strain also utilizes cholesterol-/dynamin II-dependent endocytosis. In contrast, by depleting caveolin-1 using nystatin, siRNA, or a DN mutant for caveolin-dependent endocytosis, we demonstrated that entry of PSaV Cowden strain does not require caveolin-/dynamin II-dependent endocytosis. We also investigated the role of alternative or minor routes of PSaV entry by co-treatment with inhibitors. However, no combination of inhibitors produced a significant decrease in the rate of infection of PSaV Cowden strain over chlorpromazine or MβCD alone. Since cholesterol-dependent endocytosis is still poorly defined , the reason why the two cholesterol-sequestering drugs (MβCD and nystatin) have a different effect on the cholesterol- and dynamin-dependent entry of PSaV Cowden strain remains unknown. Nevertheless, it has been reported that the sensitivity of different cholesterol-dependent viruses to cholesterol-sequestering drugs can be different. For example, FIPV is sensitive to nystatin but not to MβCD , whereas, similar to what we observed with the human rotavirus Wa strain in this study, the simian rotavirus RRV strain is sensitive to MβCD but not to nystatin [51, 52]. In addition, CVB3 is sensitive to both MβCD and nystatin .
Recent reports have shown that PSaV Cowden strain requires bile acids, acidification, and cathepsin L activity in Rab7-positive LEs for efficient trafficking and uncoating [29, 30]. However, the detailed mechanism used by PSaV Cowden strain to travel from EEs to LEs has been unclear. In the present study, PSaV Cowden strain maximally colocalized with the EE marker EEA1 at 30 mpi, and with the LE marker LAMP2 at 60 mpi, suggesting that PSaV Cowden strain travels from EEs to LEs. Moreover, depletion of either Rab5 or Rab7 by corresponding specific siRNA trapped PSaV Cowden strain in the periphery of the cytoplasm. The data confirm that, similar to FCV trafficking , entry and infection of PSaV Cowden strain require endosomal trafficking from EEs to LEs [29, 30].
Pretreatment of cells with cytochalasin D significantly reduced the infectivity of PSaV Cowden strain, suggesting that rearrangement of actin filaments plays an important role in virus internalization. Actin has been reported to have different functions in the calicivirus life cycle for FCV and MNV [24–26]. Cytochalasin D can inhibit the later stages of the FCV life cycle, with no inhibitory effect during FCV entry . In contrast, infection of MNV-1 is somewhat increased by treatment with cytochalasin D [25, 26]. Further studies are required to examine whether post-treatment with cytochalasin D inhibits the replication of PSaV Cowden strain in virus-infected cells or in cells transfected with the viral RNA genome. The present finding that infectivity of PSaV Cowden strain diminished in LLC-PK cells pretreated with the microtubule-disrupting nocodazole suggests a similar mechanism to the one used by MNV-containing endosomes to move deeper into the cytoplasm using microtubules as an intracellular highway .
Endosomal acidification plays a crucial role during uncoating of most viruses [58, 59]. Interestingly, the dependency of endosomal acidification varies with different caliciviruses. For example, endosomal acidification is required by FCV but not by MNV [25, 26, 28]. However, the dependency of endosomal acidification for MNV infection is controversial. Two recent reports described that the inhibition of endosomal acidification and of cathepsin L, which requires acidic pH for optimal activity, significantly reduced the replication of MNV, FCV, and PSaV [29, 30]. In the present study, inhibition of endosomal acidification by chloroquine treatment significantly reduced the fluorescence intensity of the CMFDA pH probe in parallel with loss of colocalization with LAMP2 in PSaV-infected cells, suggesting that late endosomal acidification is necessary for PSaV uncoating. Furthermore, replenishment of the medium of chloroquine-treated cells with an acidic buffer induced the escape of PSaV Cowden strain from LEs and restored the infectivity of PSaV Cowden strain, confirming that uncoating of PSaV Cowden strain requires acidification of LEs. Consistent with our previous reports [29, 30] and similar to what has been observed in FCV , the findings presented here indicate that an endosomal low pH is indispensable for the uncoating of PSaV Cowden strain.
In conclusion, we provide evidence that PSaV Cowden strain enters permissive LLC-PK cells via clathrin- and cholesterol-dependent endocytic pathways that require dynamin II for vesicle fission and detachment, as well as actin rearrangements for vesicle internalization. In addition, PSaV Cowden strain requires Rab5 and Rab7 GTPases to deliver viral particles from EEs to LEs along the microtubules and acidification of LEs for uncoating and genome release of PSaV Cowden strain into the cytoplasm. These findings provide new insights into the biology of these highly prevalent RNA viruses.
MS, DSK, and Kyoung-Oh Cho designed the study. MS and DSK performed the experiments. MS, JYS, JYK, JGP, SIP, and Kyoung-Oh Cho, analyzed the data. MS, DSK, MMA, YBB, IG and Kyoung-Oh Cho helped data interpretation. MS, DSK, EHC, MIK, SIP, IG and Kyoung-Oh Cho discussed the results. MS, DSK, and Kyoung-Oh Cho wrote the manuscript. CK and Kyeong-Ok Chang provided laboratory materials. Kyoung-Oh Cho and IG edited the manuscript and provided funding. All authors read and approved the final manuscript.
We would like to thank Alice Dautry-Vautry (Pasteur Institute, Paris), Mark McNiven (Mayo Institute, Rochester, MS) and Ari Helenius (Swiss Federal Institute of Technology, Zurich) for the kind provision of plasmid constructs.
This study was supported by a Grant (2017R1A2B3002971) from the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning, Republic of Korea. IG is a Wellcome Senior Fellow supported by the Wellcome Trust (097997/Z/11/Z and 207498/Z/17/Z).
13567_2018_584_MOESM1_ESM.docx Additional file 1. Sequences of siRNAs against target molecules and scrambled siRNA used in this study.
13567_2018_584_MOESM2_ESM.tif Additional file 2. Determination of chemical-mediated cytotoxicity in LLC-PK cells by MTT assay. (A–I) LLC-PK cells grown in 96-well plates were incubated with various concentrations of the indicated chemicals in triplicate for 24 h at 37 °C. Afterward, the chemical-containing media was thoroughly removed and replaced with 200 μL of MTT solution for 4 h at 37 °C. Each well was incubated with 100 μL of DMSO for 10 min at room temperature. Cell viability was measured using an ELISA reader at an OD value of 570 nm. The arrows indicate the concentrations used in this study.
13567_2018_584_MOESM3_ESM.tif Additional file 3. Determination of chemical-mediated cytotoxicity in Caco-2 cells by MTT assay. (A–E) Caco-2 cells grown in 96-well plates were incubated with various concentrations of the indicated chemicals in triplicate for 24 h at 37 °C. Afterward, the chemical-containing media was thoroughly removed and replaced with 200 μL of MTT solution for 4 h at 37 °C. Each well was incubated with 100 μL of DMSO for 10 min at room temperature. Cell viability was measured using an ELISA reader at an OD value of 570 nm. The arrows indicate the concentrations used in this study.
13567_2018_584_MOESM4_ESM.tif Additional file 4. Determination of chemical-mediated cytotoxicity in MA104 cells by MTT assay. (A–E) MA104 cells grown in 96-well plates were incubated with various concentrations of the indicated chemicals in triplicate for 24 h at 37 °C. Afterward, the chemical-containing media was thoroughly removed and replaced with 200 μL of MTT solution for 4 h at 37 °C. Each well was incubated with 100 μL of DMSO for 10 min at room temperature. Cell viability was measured using an ELISA reader at an OD value of 570 nm. The arrows indicate the concentrations used in this study.
13567_2018_584_MOESM5_ESM.tif Additional file 5. PSaV entry depends on clathrin-, dynamin-, and cholesterol-mediated endocytosis. (A and B) Confluent monolayers of LLC-PK pretreated with chemicals were exposed to AF594-labeled PSaV particles (approximately 415 particles per cell) for 30 min at 4 °C. To examine the effect of cholesterol replenishment following MβCD-mediated depletion, soluble cholesterol (MβCD + cholesterol group) was added to the medium and then cells were exposed to AF594-labeled PSaV particles. Afterward, unbound virus was washed off, and the cells were shifted to 37 °C for 30 min (A) or 60 min (B). Cells were then fixed, stained with AF488-labeled phalloidin for actin, and processed for confocal microscopy. All the experiments were done in triplicate and representative images are shown. The scale bars in each panel correspond to 10 μm.
13567_2018_584_MOESM6_ESM.tif Additional file 6. Transport of PSaV particles to early and late endosomes. LLC-PK cells were incubated with AF594-labeled PSaV particles (approximately 415 particles per cell) for the indicated time, fixed, permeabilized, and processed for the immunofluorescence assay to determine the colocalization of AF594-labeled PSaV particles with the early endosomal marker EEA1 (A) and the late endosomal marker LAMP2 (B). All experiments were performed in triplicate and representative images are shown. The scale bars in each panel correspond to 10 μm.
13567_2018_584_MOESM7_ESM.tif Additional file 7. PSaV infection is pH-dependent and involves actin and microtubules. LLC-PK cells were either mock-treated or chemical-treated and then infected with PSaV Cowden strain. The cells were then stained with an antibody against the PSaV VPg protein and the number of virus-positive cells was counted by confocal microscopy. Results are shown as the percentages to the number of positive cells in the DMSO vehicle-treated control. All experiments were performed in triplicate. Data are presented as mean ± standard deviation of the mean from three independent experiments. Differences were evaluated using the one-way ANOVA. *P < 0.05; **P < 0.001; ***P < 0.0001.
13567_2018_584_MOESM8_ESM.tif Additional file 8. Caveolin-mediated endocytosis and macropinocytosis are not used as a minor route for PSaV entry. Confluent monolayers of LLC-PK were treated with DMSO, chlorpromazine (CPZ) alone (-), CPZ and nystatin, CPZ and amiloride, MβCD alone (-), MβCD and nystatin, or MβCD and amiloride prior to infection with the PSaV Cowden strain. The cells were then stained with an antibody against the PSaV VPg protein and the number of virus-positive cells was counted by confocal microscopy. Results are shown as the percentage of infected cells normalized to the results obtained with control DMSO-treated cells. Data are presented as mean ± standard deviation of the mean from three independent experiments. Differences were evaluated using the one-way ANOVA. *P < 0.05; **P < 0.001; ***P < 0.0001. | 2019-04-26T05:51:40Z | null | 734.7 | 49,421 | null | 0.113717 | [
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Day rates include camera, operator, lights, microphones, and tripod. Special requests for equipment can be accommodated if given advance notice (additional fees may apply).
A down payment is required to secure booking dates.
Discounts are given to non-profits and for multiple days booked.
Special packages are also available.
PKP is available to produce content using client equipment (editing and shooting) for a reduced fee. | 2019-04-21T16:53:39Z | null | 377.6 | 427 | null | 0 | [] | [] | true | [] |
This is one of our most frequently asked questions and with a Course Director Training Course starting next week in the Dominican Republic, I thought it was a good time to explain the current route.
If you are a PADI Instructor you will be familiar with the concept that every PADI Instructor goes through an Instructor Development process followed by an Instructor Examination conducted by PADI Examiners. This ensures that every PADI instructor reaches the same minimum level of knowledge, personal and teaching skill and provides enviable consistency as well as an amazing experience for all involved.
Once you were a PADI Instructor I’m sure you went on to teach specialties, maybe became an IDC Staff Instructor and/or a TecRec Instructor, increasing your knowledge and skill as you progressed.
The route to TecRec Instructor Trainer is very similar. Your first step is to become a Course Director by completing a Course Director Training Course with PADI staff.
If you are thinking, “But I only want to teach tec instructors” then I understand, because I felt the same at first. What I didn’t realise was that the CDTC is an absolutely amazing experience. I thought it would be similar to the IDC, but it is far, far more than that – as is appropriate to the level. Not only do you get to learn from PADI’s most experienced staff (and some of them have been around for a long time, so there is a lot of experience to learn from ;-)) but your fellow candidates are also some of the most experienced diving instructors, dive business owners and managers in the world.
During the course you have access to all of that knowledge and experience, so make the most of it. The atmosphere is open and fun, but professional and dedicated and during my course I soaked up as much of everyone else’s knowledge and experience as I could. I came back bursting with ideas that made their way into our business over the next few years.
As with Instructor levels, learning to teach the initial instructor courses gives you the skills to be an Instructor Trainer and you can then move on to become a Specialty Instructor Trainer and TecRec Instructor Trainer.
TecRec Instructor Trainer certifications have differing requirements, depending on the level, but all levels require additional experience beyond the instructor level requirements and an orientation to the instructor course.
If you would like to know more about becoming a PADI Course Director your first port of call is to chat to you Regional Manager. They will be able to help you with the application process and advise on your individual position.
If you are already a PADI Course Director and would like to know more about becoming a TecRec Instructor Trainer click here to find your regional TecRec Training consultant, who can help explain the route to your desired TecRec Instructor Trainer level. | 2019-04-20T22:25:48Z | null | 267.3 | 2,854 | null | 0 | [] | [] | true | [] |
Clashing for the second time against its toughest Great Basin Conference opponent, the Wood River High School tennis team turned it around and beat Minico 9-3 Tuesday on the Hailey courts. Wood River’s boys beat Minico 3.5 to 2.5, and the Hailey girls prevailed 5.5 to 0.5.
Back on April 4 in Rupert, Minico captured a rare 7-5 team victory over the perennial tennis powerhouse from Wood River. In that meet, Minico swept girls’ singles and split the doubles matches 3-3. But on Tuesday, Wood River swept girls’ singles and won five of the six doubles matches.
Top surprise was Wood River senior Lily Richards winning her No. 1 girls’ singles match in straight sets over previously unbeaten Eva Mollik of Minico. Mollik is a German foreign exchange student who is shooting for a district girls’ singles title before returning to her country in June.
Also, Tayte Kelly rallied from a 6-4 first-set loss at No. 3 girls’ singles to sweep the next two sets 6-1, 6-1. Stephen Pfeiffer won in straight sets at No. 1 boys’ singles, and Wood River’s five doubles victories also came in straight sets.
Wolverine seniors playing their final home matches were Audrey Brassil, Alex Feldman, Margaret Reutter, Lily Richards, Cole Caminiti, Josh Morell and Jose Juarez.
Hailey played at the Community School Thursday, after which coach Carlos Meza’s Wolverines aim for the state-qualifying GBC district tourney Wednesday and Thursday, May 8-9 in Twin Falls.
Next week’s district tournament will be played at five sites—the College of Southern Idaho courts (boys’ doubles), Harmon Park (girls’ doubles), Frontier Field (mixed doubles), Canyon Ridge High School (girls’ singles) and Twin Falls High School (boys’ singles).
The top four finishers in each event will represent the district at the State 4A tournament May 17-18 at Boise Racquet and Swim Club.
Boys’ singles: 1—Stephen Pfeiffer (WR) 6-2, 6-1 over Cameron Jackson (M). 2—Derek Wilkins (M) 6-1, 4-6, 6-1 over Michael Niedrich (WR). 3—Travis Halverson (M) 6-3, 6-4 over Jose Juarez (WR).
Girls’ singles: 1—Lily Richards (WR) 7-5, 6-3 over Eva Mollik (M). 2—Alex Feldman (WR) 7-6, 6-1 over Kaylean Hawkes (M). 3—Tayte Kelly (WR) 4-6, 6-1, 6-1 over Rachel Rogers (M).
Boys’ doubles: 1—Cole Caminiti-Josh Morell (WR) 6-0, 6-3 over Fernando Santana-Abraham Ortiz (M). 2—Erik Wilander-Danny Graves (WR) 7-5, 6-2 over Julio Figueroa-Michael Vandever (M).
Girls’ doubles: 1—Margaret Reutter-Haley Cutler (WR) 6-1, 6-1 over Bailey Staley-Stacie Sanderson (M). 2—Alex Taylor-Samantha Taylor (WR) 6-2, 6-1 over Monica Farfan-Karen Hansen (M).
Mixed doubles: 1—Taylor Cooper-Tate Morell (WR) 6-4, 6-1 over Willemstad Bradford-Lyndon Mittlesteadt (M). 2—Joshua Evenson-Amber Long (M) 6-3, 6-4 over over Miles Remington-Audrey Brassil (WR). | 2019-04-19T00:19:48Z | null | 1,761.4 | 2,771 | null | 0.140022 | [
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Corporate Philosophy / Japan Registry Services Co., Ltd.
As a company dedicated to maintaining the network infrastructure, JPRS contributes to the development of the Internet and the building of a better future for everyone.
The Internet has become an essential part of the groundwork for today's society. Especially, domain names are crucial to Internet access. Japan Registry Services Co., Ltd. (JPRS) supports the infrastructure of the Internet on a 24/7/365 basis through the management and administration of domain names and operation of the domain name system (DNS).
Keeping up with the latest technologies is indispensable for domain name management and DNS operations. As a company supporting the network infrastructure, JPRS must offer new services to society by applying the DNSrelated technologies it has developed and acquired through the operation of domain names. For that purpose, JPRS is actively researching and developing new technologies. JP domain names are accessible not only inside Japan, but also from all over the world. Therefore, in the interest of both the global community and the community in Japan, JPRS is developing, improving, and promoting its services to ensure that JP domain names are more user-friendly and have higher value.
As a company dedicated to supporting the network infrastructure, we strive to maximize reliability and respond to the expectations of the community. Moreover, we support the evolution of the Internet by coordinating closely with Internet-related organizations at home and abroad as well as the Government of Japan. JPRS will keep making every effort to contribute to society into the future. | 2019-04-23T12:45:24Z | null | 222.8 | 1,656 | null | 0.062198 | [
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] | true | [
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A nonabsorbable, sterile, surgical, monofilament suture composed of the long-chain, aliphatic polymers Nylon 6 and Nylon 6.6. ETHILON suture is dyed black or green to enhance visibility in tissue. It is also available undyed (clear).
ETHILON™ Nylon Suture is indicated for use in general soft tissue approximation and/or ligation, including use in cardiovascular, ophthalmic, and neurological procedures.
ETHILON Suture elicits a minimal acute inflammatory reaction in tissue, which is followed by a gradual encapsulation of the suture by fibrous connective tissue. While nylon is not absorbed, progressive hydrolysis of the nylon in vivo may result in gradual loss of tensile strength over time.
Due to the gradual loss of tensile strength which may occur over prolonged periods in vivo, nylon suture should not be used where permanent retention of tensile strength is required. | 2019-04-21T05:11:32Z | null | 291.8 | 879 | null | 0.442548 | [
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Join us for a special in-store performance from Lee DeWyze at Joyride records!
Free show! Limited edition copies of “Paranoia” will be available for sale during this event! | 2019-04-26T04:57:12Z | null | 291 | 172 | null | 0 | [] | [] | true | [] |
few photos from last October.
we visited grandma last year.
Penny and Frankenstein were buddies.
until I packed him away.
oh what wonderful shots! my favorite is penny with frankenstein! | 2019-04-21T18:59:22Z | null | 4,457.6 | 186 | null | 0 | [] | [] | true | [] |
Has anyone been to the NC NP this month, what time of year does the highway close?
Here's (http://www.cascadeloop.com/travel_hints_faq.html) a website on the North Cascades loop. Haven't been up there this year but generally the highway is closed between Mazama and Newhalem between November and April.
Thanks Colin, I hadn't seen that web site, I might have to hurry before the snow comes.
I'm not extravagant hopes to travel all over Europe, but I love my trips in Spain. It is a beautiful country, and cities like menorca (http://www.aboutmenorca.com) and san sebastian (http://www.sansebastianspain.info) are all unforgettable. I'd love to go back for awhile. If you're in Barcelona be sure to check out the Picasso museum as well and the best way to get around Spain is by train. But I want to travel through all of Europe, it's my dream! | 2019-04-20T06:42:41Z | null | 316.4 | 843 | null | 0 | [] | [] | true | [] |
Like the guy who took his job at Ohio State, Tate Martell petitioned the NCAA for immediate eligibility following his transfer to Miami back in January.
And, like the guy who took his job at Ohio State, Martell won his hardship waiver.
The difference, not just between Martell and Justin Fields, but between Martell and everyone else, is that the new Hurricane's petition was based on "coaching turnover"—which was both misattributed and exaggerated.
Martell was recruited to Ohio State by the now-infamous Zach Smith while Tim Beck and Ed Warinner shared offensive play-calling duties. By the time he arrived in Columbus, Beck and Warinner were gone—replaced by Ryan Day.
Fast forward two years later, head coach Urban Meyer is gone, Day’s the head coach, and Smith’s firing off mean tweets and cashing unemployment checks.
Does that qualify as significant turnover? Evidently it does. But if a player whose head coach was replaced by his position coach can win immediate eligibility based on that? Well, then any player whose head coach leaves for any reason should—and presumably will—be welcome to transfer with immediate eligibility.
Nevermind the fact that we can all be pretty sure that Martell's reason for transferring was Fields and Fields, alone. It’s impossible for a player to have more familiarity with his new head coach, two years in, than what Martell has with Day.
Compare that to what happens every year at Alabama.
For that matter, compare that to basically every head coaching change that took place this winter at every program other than Ohio State.
Count this as a win for the student-athlete if you want to. You wouldn't necessarily be wrong in doing so. But understand that this right here is going to mean open season on the campuses of any program that experiences a coaching change in the future. | 2019-04-25T08:15:36Z | null | 362 | 1,825 | null | 0 | [] | [] | true | [] |
Latham- Shelly Ann Cavotta-Trifiletti-Roux, 52, passed away April 10th, 2019 surrounded by her family and loved ones. Shelly was born January 15th, 1967 as the daughter of Ted Cavotta and Patricia Barr. She attended and graduated from Shaker High School in 1985 with high honors. She worked for Schenectady County Public Health for the better part of her life helping others in the community. Shelly was known by her loved ones for always having an open heart for those in need. She was unconditionally loved by her children in every aspect of life.
Her legacy will continue with her children Brittney Trifiletti (daughter), Katlin Trifiletti (daughter), James Trifiletti (son), Briana (step-daughter), Christopher (step-son), Nikki Chuley (niece), Ted Cavotta (father), Orin Barr (step-father), Kimberly DeVoe (sister) and grandson Kaiden Trifiletti.
Shelly’s wake will be held Wednesday, April 17th, 2019 at New Comer Funeral Home, 181 Troy Schenectady Road, Watervliet, NY 12189 between the hours of 4:00pm to 7:00pm. Her funeral service will be private at the convenience of the family.
Add your memories to the guest book of Shelly Cavotta-Trifiletti-Roux.
Rest in peace, Shelly. You're with the Lord and he will always be with you.
Thanks for looking out for Lorenzo all those years! I was always grateful. | 2019-04-21T10:15:50Z | null | 982.1 | 1,312 | null | 0 | [] | [] | true | [] |
From November 28-December 1, a group of 4 HPA faculty and administrators and 5 HPA Upper School Students attended the NAIS People of Color Conference and NAIS Student Diversity Leadership Conference in Nashville, Tennessee. HPA was one of three Hawaiʻi independent schools to send adults to the People of Color Conference, and one of only two Hawaiʻi schools to send delegates to the Student Diversity Leadership Conference. The learning that took place at the People of Color Conference and the Student Diversity Leadership Conference is a powerful beginning, but it is just that: a beginning. In our classrooms, offices, and our daily work in the campus, we must continue to build our understanding, build context, and be equity and inclusion leaders.
In a place as multicultural as Hawaiʻi, it can be easy to wonder why we would send 9 of our community members to a conference focused on the theme of diversity and identity in education. Many people already look to Hawaiʻi as a place that has achieved deep cultural, ethnic, and racial integration. What could we as an already diverse school have to learn about this topic? I will turn to the words of one of the faculty attendees, written upon return from the POCC, for an answer: “We have a naturally welcoming school community, but that doesn't mean that all voices are heard, or that our students are prepared to take part in social discourse.” While we have much to celebrate with regards to diversity, there is also much that we can continue to learn about how to ensure that every member of our school feels included, represented, and heard. “Welcoming,” while important and valuable, is not the same as “inclusive,” which requires more focused, deliberate work by all community members.
Diversity is integrated into HPA’s Strategic Plan and Task Force work. Three of the POCC attendees are members of the Diversity Task Force. At the conference, they attended sessions that can contribute to our understanding of our school-wide inclusion efforts. Upon return to HPA, adult attendees shared the following reflections: “One thing that struck me... is that we, as teachers, need to be very careful with our words. We may think we’re joking or connecting with students, but they may not take it that way and it may affect them for a very long time. Issues connected with diversity and inclusion can be such a sensitive area for a developing child or teen. We all know this, but in the rush of a school day, we can forget the weight of our words on young people’s ears and their positive development.” Another wrote, “I personally will be thoughtful and careful about every word I say and write. I will step in more strongly when I hear anything that should not be said. I still feel I need help with this though...I will continue to provide a safe space and an ear for our students. I will make sure everyone is seen.” (for student reflections on the Student Diversity Leadership Conference, please see the December K-12 notes). | 2019-04-25T09:07:56Z | null | 351.8 | 2,987 | null | 0 | [] | [] | true | [] |
The contact can come from online friends you don’t know or someone you know in the offline world.
Tell someone you trust, like your mum, dad or another adult.
Don’t respond and leave the site or chat session.
Block the contact or remove them from your friends list.
Contact your ISP and/ or phone provider, or the website administrator. There are actions they can take to help. | 2019-04-21T07:08:34Z | null | 576.4 | 377 | null | 0 | [] | [] | true | [] |
Seasonal - call store for hours.
Locally owned and operated our staff has been serving the Leech Lake community for over 30 years.
Located on Highway 371 in Walker, MN. We also have a protected Marina Facility on beautiful Leech Lake with 110 boat slips.
We are a proud dealer of the following: Tracker Boats, Harris Pontoons, Avalon Pontoons and Barletta Pontoons as well as Mercury Engines.
Our dealership offers full service and repairs as well as parts and accessories. We also offer boat storage, winterizing and detailing and have pontoon rental available. Our marina offers full amenities including gas dock and pump out and power hook ups. | 2019-04-19T00:20:31Z | null | 815.9 | 647 | null | 0 | [] | [] | true | [] |
This package is designed for the elderly. You will get all the basic knowledge that you will need to operate a computer. This will introduce you to the exciting world of Computers, E-Mail and the Internet including Social Media and Networking websites such as Facebook; YouTube and Skype. | 2019-04-22T02:46:01Z | null | 259.6 | 288 | null | 0 | [] | [] | true | [] |
We offer you a drag & drop File Manager, which features a collection of handy instruments like an integrated graphic viewer and a range of file editors. You can easily make rapid uploads, archive/unarchive files, modify permissions and far more. The software tools are well–organized and very easy to get through with huge action keys and right–click context navigation. Have a look at the various applications and features integrated in the Christian Web Hosting Professionals File Manager.
The File Manager in your Hosting Control Panel features a quick, drag’n’drop feature that can help you move data files between your personal computer and your hosting account without needing to work with an FTP (File Transfer Protocol) tool. You could drag files from your PC and drop them in your Hosting Control Panel with a click of the mouse through a secure SSL connection.
The drag’n’drop functionality is built into the Hosting Control Panel, therefore, you will not need to set up any third–party software pack to use it. It also works well on all major Operating Systems, so all you have to do to employ it is sign in to your File Manager.
A large number of File Managers specify all the activities that one can conduct over a file or folder at the top of the webpage. We believe that the latter is just not user–friendly enough. Thanks to the File Manager, you can access all of the file administration options at the time you right–click a file or directory. This method is also applicable for a group of files/folders.
You can actually rename, copy, move, download, edit, preview, archive, unarchive and delete any file or folder you decide with just a mouse–click.
Due to the built–in archive/unarchive option, the File Manager really helps to manage huge files with no need to use FTP. It is simple to shrink a directory into a compact size by clicking on the Compress button or access the belongings in an archived directory by using the Extract button. Whenever compressing a folder or a variety of files, it is possible to decide on the archive extension (.ZIP, .RAR or .TAR.GZ) along with the title of the archive file.
Our File Manager makes it possible for you to modify your files directly on the web server never having to download, transform and subsequently re–upload them. It is easy to adjust your files directly on the Internet, by making use of the internal editors. We provide you with a code editor having syntax emphasizing for your .JS or .PHP files, a WYSIWYG editor for HTML files, along with a regular text editor for the more competent customers.
You have access to every file editor when using the right–click contextual menus. All changes produced to the files appear instantaneously online – it’s possible to directly examine them within your Internet browser.
When you’re handling a great number of websites concurrently, it’s vital that you have everything arranged. With many other File Managers, updating a lot of websites inside the exact same hosting account can be extremely challenging. With the File Manager, you will see that it’s in fact really simple. Every single web site has its own folder, that you can at once acknowledge, including all of the files pertaining to the specific web site are found there.
And also to make everything so much easier, we have a drop–down navigation where you can quickly pick on which host you want to work in the File Manager. Our smart system will lead you there in no time.
Working with your files is instinctive and hassle–free with the Christian Web Hosting Professionals Hosting Control Panel. You are going to try a file managing setting that is very close to your desktop PC’s file explorer. You can drag & drop files and manage all of them with a right mouse–click. With the integrated preview option, you will observe pictures exactly like they will show up online, and throughout the in–built file editors you could make improvements for your files immediately.
If you need guidance handling your files, you are able to take a look at the large collection of posts and how–to video clips, which you could find using a mouse–click.
The File Manager will help you save lots of time when making use of multiple files. You can actually pick different files simultaneously and use a desired action for them exactly like you do on your desktop computer or laptop. To choose random files at once, simply press the Control key, and to pick a collection of adjacent files, press the Shift key. It’s that simple.
After you have selected the files, you are able to instantly transfer them to an additional location when using the drag & drop option. By making use of the right–click context menu and also the buttons on top of the file table, you can actually use a number of other actions – it’s possible to copy, rename, delete, download and change your files, adjust file permissions, and so on.
Password protection is the best way for you to control the access to a particular section of your website that you do not plan to be seen to everyone. As an example, this can be a safe and secure members’ place or an area with copyrighted information that you want only a number of customers to view.
From the File Manager you can password–protect your website or maybe a specified folder inside it with a click of the mouse. Simply right–click a directory, select Password Protection and add the login name and then password. There is no need to take care of .htaccess files as well as to come up with any other adjustments. In the future, simply the site visitors which have your login name and security password will access your web site. | 2019-04-23T14:54:18Z | null | 393.7 | 5,617 | null | 0.310486 | [
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To be the preeminent global hr consulting firm in the international mining & resources sector.
Our mission is To Serve the Global mining industry by partnering with companies who seek to build great teams with contemporary, creative and custom-fit human resource and recruitment solutions.
Globe has built its business on core beliefs & values that underpin every decision and action we take for both internal and external stakeholders.
Our 8 Core Values help guide us and act as an invaluable reference point for today and into the future. | 2019-04-20T02:24:40Z | null | 525 | 540 | null | 0.281481 | [
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Though it’s still freezing outside, Sony’s holiday season heated up the competition, selling more than 90 million PS4s as of December 31. In addition to being the fourth best-selling console of all time–currently behind the Wii, PlayStation, and PlayStation 2–Sony has announced that Insomniac Games’ Spider-Man has sold 9 million units digitally and physically as of November 25. To shed more light on the rest of the company’s stellar holiday season, Sony has released an official list of its top downloads for December 2018.
Leading the pack of PlayStation 4 games is PUBG Corporation’s battle royale title PlayerUnknown’s Battlegrounds, which launched on December 7. Following that is Treyarch’s Call of Duty: Black Ops 4 which has its own battle royale mode, Blackout. In third is Rockstar’s Grand Theft Auto V, a game that released during the last console generation and is still, ostensibly, making the studio a lot of money.
Moving over to PlayStation VR, it’s Beat Games’ Beat Saber on top. Second to the lightsaber rhythm game is Owlchemy Labs’Job Simulator, a game that released nearly three years ago. Placing in third is SIE London Studio’s PlayStation VR Worlds, a compilation of games Sony released alongside the company’s virtual reality headset back in October 2016.
On the free-to-play side of the PlayStation Store is, of course, Epic Games’ Fortnite–no surprise there. Taking the second spot is Crytek Kiev’s Warface. Following in third is yet another battle royale game, Daybreak Game Company’s H1Z1: Battle Royale.
Though Sony’s finally putting the PS Vita to rest by discontinuing production of the console’s physical games, the system still sold an approximate 15 million units in its lifetime. As such, Sony decided to document the top games the handheld sold in December. In front is SIE Santa Monica Studio’s God of War Collection. Following in second is Mass Media Games’ Jak and Daxter Collection. In third is Kojima Productions’ Metal Gear Solid 3: Snake Eater HD Edition. | 2019-04-21T02:37:09Z | null | 368.3 | 2,002 | null | 0 | [] | [] | true | [] |
Made with premium Baltic birch wood, each card is left untreated so it is safe for your little ones to chew on!
All of our sets come in a cotton muslin bag for easy storage!
Don’t forget to check out our Newborn cards to add to the set! | 2019-04-22T00:45:43Z | null | 525.6 | 236 | null | 0 | [] | [] | true | [] |
These folding table trucks provides neat storage and transportation of 4', 5', 6? and 8'. Can be used for Plastic or Laminate Tables that fold and are laid flat, stackable up to 12 table high. Rolls on 4 castors: 2 swivel and 2 stationary. Built with tubular handle providing stability and ease of handling. Constructed of powder coated steel; color brown. These storage carts are perfect for NPS table models BT-3072, BT-3096 and BT1872. Storage capacity may differ with other brands of tables.
This Table Dolly is made in the U.S.A.
Q: How easy are these table carts to assemble? Will I need help to put it together?
Fast Shipping: Orders for the National Public Seating DY3096 generally leave the warehouse within 2-4 business days.
Dimensions: 91" x 31" x 9" | 2019-04-26T02:00:40Z | null | 2,302.3 | 762 | null | 0 | [] | [] | true | [] |
You earn 5 Phonezip Rewards Points when you buy this Airvoice $5.00 refill!
You are buying a brand new Airvoice Wireless $5.00 refill PIN for just $4.99! Refill PIN number is delivered to you electronically on-screen, we do not mail an actual card. You will use this PIN number to reload your Airvoice Wireless account using the refill instructions provided below. When you refill your phone, you get the exact same minutes, features, expiration, etc., as if you bought a physical refill card! | 2019-04-24T03:19:27Z | null | 2,025 | 493 | null | 0.701826 | [
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Belmont End Table By Bernhardt on-line shopping store. Prior to shopyou can verify for price, shipping price and more. By click Check Price! Button.
Please have a few moments to see the Belmont End Table By Bernhardt details and features. This producrs is High Quality and Fast Shipping for that store. Click on the link below to See Price, Product Description and Customer reviews for Shipping available within the USA.
You can order Belmont End Table By Bernhardt after check, compare the prices and check day for shipping. Some people are are interested to buy Belmont End Table By Bernhardt on the cheap price. While the item could possibly be priced similarly at different shops. | 2019-04-24T16:18:50Z | null | 1,802.6 | 684 | null | 0.709064 | [
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MPs are asking the government to offer financial support and advice to make it easier for older people to downsize.
Within the ‘Help to Move' shceme would be a stamp duty exemption for older people buying homes worth up to £250,000, an equity loan offer and comprehensive advice linked to new pensions freedoms, reports Inside Housing.
The recommendations come out of an inquiry by the All Party Parliamentary Group (APPG) on Housing and Care for Older People.
Anaylsis by the think-tank Demos, has found that 58% of people over the age of 60 are interested in moving and a third of over 60s want to downsize.
Exempting older people from paying stamp duty on lower value homes would reduce transaction costs, it adds, and lead to a net gain for the treasury because of the resulting moves in the property market.
Lord Best, chair of the APPG on Housing and Care for Older People, said: "More and more people in their ‘extended middle age' are thinking about downsizing. This can mean much reduced fuel bills and maintenance costs, perhaps the release of some capital, and can prevent a forced move in later life. But down-sizing is not easy. Our report recommends a Help to Move package of Stamp Duty relief, financial advice and mortgage support - like the Help to Buy assistance for younger purchasers - to generate the demand that will get more high-quality homes built for this age group."
Claudia Wood, chief executive of Demos and author of the report, said: "A lack of suitable properties and the practical and emotional upheaval of moving can't be underestimated - but affordability is also a major barrier for many. The government needs to commit to really helping this group of people, with concrete policies - not just to ensure older people enjoy a better quality of life but also to stimulate the entire housing market by helping more older people move from family-sized homes." | 2019-04-22T16:54:21Z | null | 487.9 | 1,891 | null | 0 | [] | [] | true | [] |
Health care providers face the stress of patient care every hour of every day, and in most cases they handle that stress well. But then there are those times when normal stress blows up into something potentially traumatic–the unexpected loss of a patient; a troubling encounter with a family member; even a run-in with a colleague over care management. At these times, otherwise steady professionals can become psychologically or emotionally devastated “second victims,” who could use prompt support from peers. Most hospitals and other health care facilities, however, do not have a support system in place, and without support, caregivers experience reduced productivity, increased self-doubt and, in some cases, long-term depression.
Caring for the Caregiver: Implementing RISE (Resilience in Stressful Events) is a training program that teaches you how to set up a peer-to-peer support program in your hospital and how to teach a multi-disciplinary team of hospital volunteers how to respond and support a team member involved in an unanticipated patient event, stressful situation, or patient-related injury.
Day 1: Implementation Training — This is a training day for the leadership team, quality/safety leaders, and risk management leaders.
Day 2: Peer Responder Training — This training usually occurs 4-8 months after implementation training and is designed for the peer responder team.
You also receive training manuals which include the content, tools and video links that support the program.
Click on the video below for an overview of the program.
This research paper describes the development of RISE at The Johns Hopkins Hospital and evaluates its initial feasibility and subsequent implementation.
Albert Wu, M.D., began his research on “second victims” in 2000, envisioning a program that provided support for health care providers experiencing adverse clinical events.He is a professor of Health Policy and Management at the Johns Hopkins University Bloomberg School of Public Health, the director of the Center for Health Services and Outcomes Research and director of the Certificate Program in Quality, Patient Safety & Outcomes Research.
Matt Norvell, Mdiv., is the pediatric chaplain at the Johns Hopkins Children’s Center. In his role as chaplain, Matt has spent his career providing spiritual and emotional support to individuals in crisis. He sees the Caring for the Caregiver program as a fantastic way to broaden the reach of supporting hospital employees who face stressful events every day. Matt is a Board Certified Chaplain and a Nationally Certified Counselor. He currently serves the patients, families, and staff of the Johns Hopkins Hospital Children’s Center.
Hospitalist Engagement Survey Gain insights into your hospitalists’ on-the-job satisfaction and the likelihood of retention. | 2019-04-25T14:10:30Z | null | 251 | 2,823 | null | 0.040737 | [
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1.Do you love your existing home?
It’s important to love your home! Why? It where we spend most of our quality time with our families. If you don’t love the main aspects of your home, whether it be the location, size, layout or aesthetics, then maybe the right option for you would be to sell! Buy and fall in love with something that fits to your needs. Then, and the time spent wanting to make changes can be spent appreciating and really living in your home.
Renovation is all about fine tuning what you already have to better suit your family’s needs and wants. Your home needs to have the right foundations for a renovation, so that it really reflects what you want to achieve.
2. How much are you knocking down?
Let’s be honest, if you’re knocking down or replacing more than 70% of the original structure, you’re going to lose all cost efficiency and you may as well demolish and start a new build. Knocking down a large proportion of your home could also put you in great danger of over capitalising.
We understand that when you’re planning to build your dream home it’s an exhilarating experience and it’s easy to let the costs get away from you. Quite often people start with a modest idea and budget and get caught up in the design whirlwind and end up committing every last dollar they have before the project even starts.
Our belief is to only sell our product to those who can comfortably afford it. As a rule of thumb, you should aim to have between 10% to 20% of the projects value in reserve funds. In some cases there can be unforeseen costs like electrical or footing blow outs. The main reason to not over spend is to make the experience enjoyable and rewarding for you and your family.
4. To DIY or not?
Renovations and extensions can be extremely rewarding and there’s plenty of advice out there to help you in your decision making. It’s always tempting to do all things DIY, especially when looking at your budgets. If you’ve even got the basic skills sorted, like painting, you can save a lot of extra cash. If you’re not sure on the big things, like laying tiles or pouring a slab- it’s probably best to call in the professionals!
5. Does this sound like you?
If you’ve said yes to the above…then renovating could be a perfect fit for you. One of the most rewarding experiences in life is building a beautiful home that suits your family.
If you’re not sure what your current home could look like- grab some inspiration from our website here. If you’re committed to renovating, and if it’s the right life choice for you, please give us a call for a chat today. | 2019-04-21T18:23:41Z | null | 335 | 2,585 | null | 0 | [] | [] | true | [] |
The distance between Winnipeg, Manitoba, Canada and Julianehb, Greenland is approximately 3,352 km or 2,083 mi.
To reach Winnipeg, Manitoba in this distance one would set out from Julianehb bearing 272.5° or W and follow the great circles arc to approach Winnipeg, Manitoba bearing 229.4° or SW .
Winnipeg, Manitoba has a warm summer continental/ hemiboreal climate with no dry season (Dfb) whereas Julianehb has a tundra climate (ET).
Winnipeg, Manitoba is in or near the cool temperate steppe biome whereas Julianehb is in or near the boreal rain forest biome.
The altitude of the sun at midday is overall 10.8° higher in Winnipeg, Manitoba than in Julianehb.
The table shows values for Winnipeg, Manitoba relative to Julianehb. You can also view this comparison the other way around from the perspective of Julianehb vs Winnipeg, Manitoba. | 2019-04-23T05:59:23Z | null | 1,105.4 | 842 | null | 0.492874 | [
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It is generally considered bad practice to wire an event registration refnum wire to multiple event structures.
This test is saved in LabVIEW 2013. Follow the instructions here to install and use this test.
"It is generally considered bad practice to wire an event registration refnum wire to multiple event structures"
Minor correction: it is unequivocably a terrible idea to bind this registration simultaneously to multiple Event Handler Structure.
Though, it's possible to unbind from one Handler and rebind with another, so long as no time overlaps where both handlers are bound to the same registration.
In that repo, 04 - Demonstration - Effect of Branching Event Registration.vi and 03 - Demonstration - Dynamically Rebind Event Handlers.vi demonstrate these two principles.
Jack, this is a _fantAstic_ demo. | 2019-04-22T11:01:41Z | null | 989.1 | 816 | null | 0.269608 | [
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2016-09-03· We have explained here the basic theory of transformer and working principle of transformer.
The transformer is based on two principles: first, that an electric current can produce a magnetic field (electromagnetism), and, second that a changing magnetic field within a coil of wire induces a voltage across the ends of the coil (electromagnetic induction).
The working principle of transformer is based on Faraday's laws of electromagnetic induction.According to Faraday's law,whenever there is a relative space (or) time variation between magnetic field and set of conductors an emf will be induced in the conductors,vice-versa.
Therefore, it is important to know the working principle, construction and types of transformers used in different analog circuits. What is a transformer? A transformer can be defined as a static device which helps in the transformation of electric power in one circuit to electric power of the same frequency in another circuit.
First thing to note here that though the name suggests it to be Transformer but construction wise it is like a Slip Ring Induction Motor. The basic concept behind the VFT is a rotary transformer with three phase windings on both rotor and stator.
principles of transformers remain the same, the challenges of maintaining and testing transformers have evolved along with transformer design and construction.
What is the basic component in DC or AC power supplies? Of course it is the electrical transformer. Ever wondered how do transformers work? If this question comes to your mind often, you are definitely at the right place.
The Voltage Transformer can be thought of as an electrical component rather than an electronic component. A transformer basically is very simple static (or stationary) electro-magnetic passive electrical device that works on the principle of Faraday's law of induction by converting electrical energy from one value to another.
Construction of Single Phase Transformer, Principle of Operation of Single Phase Transformer A TRANSFORMER is a device that transfers electrical energy from one circuit to another by electromagnetic induction (transformer action).
The working principle of transformer is very simple. It depends upon Faraday's law of electromagnetic induction . Actually, mutual induction between two or more winding is responsible for transformation action in an electrical transformer.
Working Principle of Transformer The working principle of transformer is very simple. Mutual induction between two or more windings is responsible for transformation action in an electrical transformer.
Working Principle of a Transformer The basic principle on which the transformer works is Faraday's Law of Electromagnetic Induction or mutual induction between the two coils. The working of the transformer is explained below.
Most of the electronic circuits used in transformer .He have different applications of the transformer. Therefore, it is important to know the working principle, construction and types of transformers used in different analog circuits.
Power Transformer Working Principle, Construction and Types Transformer is a common word for an electrical engineer and engineering student. In this post I will discuss about what is transformer, its working principle, transformer construction, types of transformer and transformer testing .
Working principle of a transformer A transformer is static (or stationary) piece of apparatus which: 1.Transfers electric power from one circuit to another.
The transformer Ratio Bridges are becoming increasingly popular and are being used for a wide range of applications.This is on account of versatility and accuracy of Ratio Transformers, which are used in the transformer ratio bridges.In fact, transformer ratio bridges are replacing the conventional ac bridges at a rapid rate.In this, we will discuss transformer ratio bridge working principle.
Working Principle of LVDT The working principle of the linear variable differential transformer or LVDT working theory is mutual induction. The dislocation is a nonelectrical energy that is changed into an electrical energy .
A transformer (Figure 1) is a magnetically-operated device or machine that can change values of voltage, current, or impedance in a given electrical circuit without any change in frequency. | 2019-04-20T22:15:31Z | null | 407.1 | 4,326 | null | 0.524272 | [
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I think I really can’t spend a day without writing a DIY 😛 I think I have DIY obsessive disorder.hehehe!! So, not to mention, I am here again with a super simple DIY for you. And this is something everyone would love for sure. You know why? Because it is a skin lightening face pack, in short, a super easy method to clear you complexion and brighten up the face. Suitable for every skin type.
Let’s have a look at others.
Smash one ripe banana in a small bowl. Add a teaspoon of honey and mix it. Now, add a teaspoon of lemon juice and mix again. Mix it till you get a right consistency of the pack to be applied on face.
What now? Your face pack is ready.
Apply it on your face and let it rest there for about 15-20 minutes. You can apply this pack all over your face and neck.
The best part about this pack is that it can be used for every skin type and you can apply it daily or if you wish, twice a week. This really brings out the glow from inside and naturally clears your complexion, hence, acting as a skin lightening face pack. | 2019-04-20T14:33:22Z | null | 556.6 | 1,037 | null | 0 | [] | [] | true | [] |
Android 8.0 introduces Notification Channels. Any application targeting the API Level 26 or higher is required to add support to notification channels, or its notifications will not be displayed.
Fortunately, Batch comes with full builtin support for them: The SDK will register a default channel for your notifications, but many APIs are available to carefully configure it to send the right notification to the right channel.
Note: You will need Batch 1.9.1, and support-v4 v26.0.0 if you target Android 8. Older versions will not display notifications properly.
Once used, an application cannot change a channel's setting anymore, letting the user retain full control on them. This also means that these settings cannot be controller on a per-notification basis anymore, or from your own App's UI: Batch.Push.setNotificationsType() is affected by this, as any flag other than ALERT will be ignored on API 26+ devices.
With Batch 1.9.1 or higher, the default behaviour is to register a channel named "Notifications", which ID is defined by BatchNotificationChannelsManager.DEFAULT_CHANNEL_ID.
Or by providing an interceptor: Batch will call it before displaying any notification, giving you a chance to override (or not) the channel ID according to the content.
These two ways to change the channel ID are not mutually exclusive: you can use both at once.
Note: Batch will not try to register these channels. If you override the channel ID, it becomes your responsibility to manage it.
If you register your own channels, but would like to keep Batch's default fallback, you can still rename the user-facing channel name.
You can give Batch an implementation of the BatchNotificationChannelsManager.ChannelNameProvider interface, which will be called when Batch registers its channel with Android.
Note: Like other global Batch configuration methods, these should be called in your Application's onCreate. Since this user-facing string is localized, your provider might be called on locale change.
Since your app can't change any channels settings, you might want to show a button redirecting them to these settings, if you detect that they disabled the notifications.
// Note: that will only work if Batch showed a notification once: the default channel is not registered beforehand. You should check if that channel has been registered beforehand.
If you're using a custom implementation of the Notification Builder in your own receiver, you will have to register your own channel, and set it in your notifications. | 2019-04-23T04:01:19Z | null | 695.2 | 2,518 | null | 0 | [] | [] | true | [] |
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Gold-i has been crowned the winner of the inaugural Ultimate Fintech Workplace Award 2018 – an award which celebrates the most innovative, engaging and inclusive fintech work environment across the UK.
Crypto Switch™ 2.0 provides brokers worldwide with a fully cleared cryptocurrency product and a cost-effective, efficient means of accessing multiple cryptocurrency market makers who can provide deep pools of liquidity as a CFD or physical asset.
Gold-i has been shortlisted in two categories, Best Connectivity Provider and Best Cryptocurrency Solution Provider, in the London Summit 2018 Awards. | 2019-04-21T18:51:14Z | null | 493.3 | 1,942 | null | 0.408342 | [
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IT’S DAD’S DAY THIS COMING SUNDAY, SEPTEMBER 7 – MAKE HIM FEEL APPRECIATED WITH A HANDMADE CARD AND FILL IT WITH VOUCHERS FOR KID-POWERED CAR WASHES, LAWN MOWS AND BACK MASSAGES TO SHOW HIM HOW MUCH YOU CARE.
These cards are so easy; anyone can make them. It’s just template for any kind of card really – in fact you can choose a special photograph or fun paper and you’ve got a lovely card for any occasion! The trims, eyelets and stitching add a neat touch.
STEP 1. CARD BASE: Fold cardstock in half and crease fold firmly so you have an A5 card.
STEP 2. MAT: Cut one contrasting piece of card 19x13cm for the mat.
TO DECORATE: Cut one 18x12cm piece of patterned paper or take a 5×7 photograph, centre it on the mat card and glue it in place.
Then punch eyelets in each corner and thread each eyelet with a piece of twine or ribbon, knot in place. Centre this component onto the card, glue in place.
Cut one 18x12cm piece of patterned paper, centre it on the mat and glue it in place.
Position a smaller photograph, offset or centred; glue in place using a small amount of glue and avoiding the edges.
Glue the entire decorated mat onto the card, once again using a small amount of glue and avoiding the edges. Using zigzag stitch, machine stitch around the edges of the photo, patterned paper and mat.
STEP 3. Type your message in a bold block font of your choice in large size such as 18 or 24 point and print on recycled paper, or hand write your message.
Cut it out and glue onto your card as desired. | 2019-04-20T18:57:36Z | null | 1,056.9 | 1,507 | null | 0 | [] | [] | true | [] |
Thanks for this video, Brandy.
Sorry if viewers must sit through a Gary Busey commercial first.
I am so obsessed with these dreamy paintings by Jeremy Miranda.
You can read an interview with the artist here.
1. Have space aliens created an underwater base off the coast of Malibu?
2. I hope this is true: Great white numbers surging.
3. Can you handle the cuteness of baby pygmy sea horses?
4. Great news: Obama expands Pacific marine sanctuary.
5. MUST SEE: White shark taste tests expensive video camera, spits it out. | 2019-04-23T04:53:17Z | null | 1,066.4 | 520 | null | 0 | [] | [] | true | [] |
Tweedsmuir TavernRecord Owner? Log in.
Have something to say about Tweedsmuir Tavern? | 2019-04-23T22:59:44Z | null | 1,811.7 | 85 | null | 0 | [] | [] | true | [] |
Wildflowers is printed with multicolored inks. It is printed in the USA on a Belgian oyster cotton and linen blend. Other materials are available, please contact us for more information. | 2019-04-20T07:10:21Z | null | 265.8 | 186 | null | 0.784946 | [
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Fort Lauderdale, Fla. – November 17, 2015 – Engage PEO, a leading professional employer organization providing HR outsourcing solutions to small and mid-sized businesses across the U.S., announced that founder and CEO, Jay Starkman, has earned the prestigious Gold Award for Chief Executive Officer of the Year in the 2015 Golden Bridge Awards. The honor was given on November 16, 2015 during a gala event in San Francisco.
Starkman was recognized for his accomplishments in building one of the fastest growing PEOs and among the fastest growing companies in the country, achieving more than 1,200 percent revenue growth over the last two years. This is the second time this year that Starkman was recognized for his leadership. In June, Starkman was the Gold winner at the national 2015 “Stevie” Awards in the Executive of the Year, Business Services category.
More than 40 judges from around the world representing a broad spectrum of industries participated and their average scores determined the 2015 Golden Bridge Business Awards winners. | 2019-04-22T16:56:59Z | null | 403.2 | 1,044 | null | 0.350575 | [
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Looking for custom trailers in Center Hill? The search is over when you choose The Trailer Boy. I can assist you in finding the perfect one. If you are in need of a car hauler, cargo, dump, enclosed, flatbed, gooseneck, horse, motorcycle, refrigerated, snowmobile or utility trailer in Florida, I can make sure you get exactly what you are looking for. I can promise this because my selection of trailers are fully customizable to your liking. Whether its the length, hitch style, height or something as simple as the color of the outer metal, I commit to providing you with what you need. The Trailer Boy is dedicated to providing our customers with an experience they’ll never forget. I go over and above in everything that I do, including customer service. You can expect professional service from start to finish. Call now for a free consultation over the phone and find out for yourself why we are considered the leading trailer company in the Center Hill area.
How’s the traffic look in Center Hill today? | 2019-04-20T02:20:57Z | null | 416 | 1,011 | null | 0.95549 | [
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What do Saudi Arabia's Crown Prince Mohammed bin Salman and the United Arab Emirates' (UAE) Crown Prince Mohammed bin Zayed say about U.S. President Donald Trump's "Golan belongs to Israel" outburst?
Are they going to have any objections against Golan Heights, which has been under occupation since 1967, Syrian land, Arab land, to be given, made available to Israel? Will they say anything, will they say "no"? Will they at least be able to say "Do not do it, this is a Syrian land"?
Are you going to object if one day they say, 'Mecca isn't yours too'?
What will they say, or will they have anything to say if one day they turn around and say, "We do not see Mecca and Medina as Saudi Arabian territory, we are going to establish a Vatican-like city there"?
All wars in the region since the 1991 Gulf War have been happening on Arab lands. Ever since that date, the Arabs lost in all these wars. The main threat that led to the ruin of Arab lands is not the outside invasion only. The Arab political mind's dependency on these invading forces is their submission, it is paving the way for them.
Trump's "Golan" outburst is the sign of a very dangerous period for the world. He had already signaled that dangerous period when he previously said, "We recognize Guaido as the state president in Venezuela."
Now, instead of telling the country that has invaded Syrian territory, "End this invasion, in compliance with the U.N. and all international agreements and laws, this land should be returned to Syria," he says, "This land belongs to Israel now."
Could there be a 'Golan outburst' for Turkey too one day?
Perhaps there is a waiting period for Turkey's outrage to die down. Perhaps new troubles are going to be concocted for Turkey, forcing it to keep silent, and this will hence be declared. This will happen. This is why we constantly insisted on an intervention in the east of the Euphrates, "regardless of the consequences."
Because we know that this is the defense of Anatolia. Because if this is not done, in the future, the defense will be in the depths of Anatolia. Because as soon as a "declaration" is made for the east of the Euphrates, preparations to form the same atmosphere for a part of Turkey will also gain speed. Because if we do not resist against all this now, if we do not take action now, one day, this nation will face a "Golan" declaration for Turkey too.
All of humanity is being dragged toward a world without sacred values - a world in which power and showdowns have the entire priority. Centuries-old accounts, files are laid on the table - and they will continue to be laid.
Do you think that one day, a U.S. president is not going to come out and say, "Istanbul does not belong to you"? How do you think this period starting with Golan today will reflect on us and the world in the future? Did they not say this on July 15, 2016? They did say it, and they said it openly, but how many of us were able to notice it?
Our primary principle is that no force from outside the region, no foreign country - regardless of the reason - should never again draw a map in this region. They should not even be able to make such a suggestion, let alone draw it. Anyone who paves the pave for them, legitimizes them, acts in cooperation with them, finds them right are in betrayal - they are enemies of Turkey and the region. | 2019-04-22T20:37:34Z | null | 282.1 | 3,345 | null | 0.736622 | [
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On November 13, 2017, the Food and Drug Administration approved its first digital pill.
Abilify MyCite is the first drug with a digital ingestion tracking system on the market. The embedded sensor records if and when the prescribed medication is taken. It does this by sending a message from the sensor to a wearable patch. The patch then transmits the data to a mobile application, where the physician and individuals designated by the patient, can access the information electronically.
The original drug, Abilify, is an anti-psychotic prescribed to individuals with schizophrenia, bipolar disorder, and as an add-on treatment for adult depression. Many patients with these conditions do not comply with their treatment plans, leading to severe consequences and significant avoidable costs. The approval signifies a new era in the development of digital health technologies, to address the issue of medication nonadherence. Medication nonadherence costs the United States healthcare system almost $100 billion dollars annually. Considering the current rates of nonadherence, digital pills could lead to significant cost savings from improved outcomes.
The development of digital medication holds much promise for improving population health and well-being. However, it also raises equally important ethical and regulatory concerns regarding patient rights, as well as data privacy and security. One of the major debates surrounding Abilify MyCite’s approval is regarding informed consent. Many physicians have expressed that the patient population, which may be distrustful or experiencing paranoia, might not be as receptive to the idea. They might be coerced into treatment by caregivers or family, without true consent. It is also widely acknowledged that there are significant risks to patient privacy, when passively collecting sensitive health data. With advancements in digital technologies, comes the need for tools to minimize risks.
The Connected and Open Research Ethics (CORE) Project at the University of California San Diego is tackling these ethical and regulatory issues in digital health. CORE is a growing network of over 450 researchers, technologists and ethicists who are shaping ethical best practices for digital health research. These include the aforementioned issues of confidentiality, privacy and security raised by Abilify MyCite’s approval. If you are not a member already, visit www.thecore.ucsd.edu to join today and engage with digital health leaders across sectors! | 2019-04-23T14:46:36Z | null | 286.3 | 2,501 | null | 0 | [] | [] | true | [] |
It’s not just the Windset Farms brand that’s part of a lifestyle, it’s the flavour and performance profiles of the produce. Windset products are more than passive ingredients. There are dishes that cannot be truly replicated with anything other than Windset Farms products. Only Kraft Dinner is Kraft Dinner. To bring this freshness home, top chefs help develop innovative recipes that leverage the unique flavour and texture profiles of Windset Farms greenhouse produce. These recipes are popular with consumers and help retailers move product. | 2019-04-23T22:21:01Z | null | 759.5 | 545 | null | 0 | [] | [] | true | [] |
I'm so sorry for my absence these last couple days. Our internet suddenly crashed and the phone company was lying and it was miserable. In the mean time I wrote up some posts for you so expect a small flood over the next couple of days. Keep tuned! | 2019-04-21T20:24:39Z | null | 639.5 | 248 | null | 0 | [] | [] | true | [] |
the slogan of our new outdoor showroom for sailing and motor yachts is both a proclamation and a promise.
We would like to invite you to spend a relaxing day here with us in Roermond. Enjoy the extraordinary atmosphere on the water and tour our permanent boat exhibition.
Allow our experienced team to show you the latest offers and benefits at the Boulevard Nautique Roermond.
Following your visit, you may want to explore the beautiful city centre or the well-known Designer Outlet Roermond located within walking distance.
Register here on our website and we will always keep you up to date on our news and events. Online or on site – it is always worth paying us a visit.
Boulevard Nautique Roermond is a marina-style outdoor showroom with berths for up to 30 sport, sailing and motor yachts.
You will find an exclusive selection of new boats and young secondhand yachts. Boatyards and small manufacturing companies have placed the best yachts from their inventories at our location.
Prospective buyers can tour and experience the yachts at their leisure: the marina has direct access to the Meuse River, making extended sea trials under real conditions possible.
There are several reasons for visiting the Boulevard Nautique when you are looking to buy a new yacht. As you embark on the adventure of a boat, we would like to be there for you from day one to give you any help and advice you may need. However, not only prospective buyers are more than welcome here. Our very competent team will also be happy to facilitate the sale of your boat.
Many years of experience on this market have taught us what really matters when selling boats. You can rest assured that we will only offer you boats that are in perfect condition and at fair prices.
We are a reliable partner of established boatyards from all over Europe. As such, we not only share the same high standards when it comes to the maintenance and care of boats, but this close cooperation also means that we can find the right solution for all of your considerations.
Take a look around on our boating page. You will find that this professional platform offers numerous pictures, technical detail and any other information you may need.
The Boulevard Nautique Roermond is located within walking distance of the Designer Outlet Roermond, Europe’s largest outlet with over 200 exclusive designer shops that draw 6 million visitors each year.
Roermond is also worth a visit: situated in the province of Limburg, Roermond is known for its picturesque historic city and Meuse Lakes recreational area.
These picturesque surroundings, which have something to offer every taste, are also home to the Boulevard Nautique Roermond.
The Boulevard Nautique Roermond can easily be reached by car, train and plane. | 2019-04-18T22:40:58Z | null | 378.9 | 2,764 | null | 0 | [] | [] | true | [] |
Frantoio Intini was established in 1928 in Alberobello, in Murgia Barese.
We offer a superior, quality oil and expertise in the olive oil market have gone from strength to strength. Experienced olive oil taster Pietro Intini has invested in research and looked at new market horizons to enrich the inherited knowledge with the most innovative studies. He has recently updated his establishment with the most modern equipment.
These factors, as well as a rigorous selection of the raw material, make Intini oil a natural, high-quality product, recognized in numerous positive acknowledgements and competitively placed amongst the best food and wine products.
The owner Pietro Intini is sure: "Quality and traceability combined with the italian style are our strengths. Our oil is made with meticulous care at every stage of the production process , with a great attention to the health of consumers and to biodiversit."
In 2013 the company has obtained a number of prestigious awards at international level, confirming as well as one of the most promising oil mills in the Italian olive oil market and very appreciated abroad.
"The modern machinery of our mill" - explains Peter Intini - "in addition to being used for our olive oil production, are also used for the work of other mills.
Specifically, continuos Intini "Ours is the only mill in the area to use the Pieralisi system continuously Molinova Serie Oro Two Phases also suitable for the common customer who wants to shatter its olives.
Thanks to this technology we can control for each batch of olives temperatures and choose between two different types of crushing, resulting in oils by the high content of polyphenols and important structure.
Continues the owner - "for the other machines we have chosen Pieralisi technology and we have equipped our mill with centrifugal extractor of the Vanguard series and the with centrifugal separator Valente. | 2019-04-19T20:32:14Z | null | 368.9 | 1,909 | null | 0 | [] | [] | true | [] |
The Executive Chairman of Kwara State Internal Revenue Service (KWIRS), Dr Muritala Awodun has disclosed the readiness of his organisation to meet up with the target of N38 billion being the estimated Internally Generated Revenue projection for the state in the 2018 fiscal year.
Awodun premised his confidence on the increasing awareness on tax payment by the people of Kwara who at the inception of the KWIRS in the year 2015 paid as taxes, N5billion but had same increased to N19billion by the year 2017.
He said the people of the state, because of the taxes they pay, has now put the state government on its toes towards churning out to them true dividends of democracy.
Awodun, stated this recently in Ilorin the state’s capital while briefing reporters on the activities of his agency in the last two years.
Awodun said there had been a drastic improvement in payment of taxes by people of the state since the agency came on board in 2015 and that this made people’s monitoring of government’s programmes to be more critical.
He said more people are paying the Personal Income Tax of N1,500 per annum by those in the informal sector and N12,000 per annum by those in the formal sector.
Awodun who described the tax as the least in the country said as moderate as it is it makes the people to ask questions about how government manages the state resources.
The KWIRS boss noted that the agency, in performing its task, had been acting as an intermediary between the people and the government.
He explained that the KWIRS had ensured that people perform their obligation of paying tax and on the other hand encouraged the government to ensure the people feel the impact of the revenue generated from them.
infrastructural projects just as it has also enabled the government to substantially devote federal allocation to payment of salary of workers.
The KWIRS boss who said the agency had been able to improve revenue from tax from about N5b it used to be before 2015 to about N19b in 2017 restated that the revenue proposed to collect this year as indicated in the state budget is N38b. | 2019-04-25T19:53:59Z | null | 601.6 | 2,091 | null | 0.567671 | [
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Have Questions? Give Us A Call Today!
Thinking about getting your Florida Real Estate Licenses?
Indian River School of Real Estate can help you pass your exams!
Enroll in Courses With Us Today!
Online classes, books, and course materials will have no refunds. Online classes cannot be converted or mixed with the classroom courses. A minimum of a $45 deposit will be required to enroll in any classroom course and will be honored for up to one year from the date of purchase, after which time the $45 deposit will be forfeited. Current pricing will apply to all courses on which deposits have been made within the one year period. No shows will receive no refunds. The 14 Hour Continuing Education Course and State Test Prep Course require payment in full and are nonrefundable.
Copyright © Indian River School of Real Estate - All Rights Reserved. | 2019-04-21T14:48:28Z | null | 532.3 | 848 | null | 0 | [] | [] | true | [] |
Yahoo attacked Facebook with 10 patents, so Menlo Park has attacked Sunnyvale right back with 10 of its own. Get the popcorn; this is the biggest real-company-versus-patent-troll battle yet.
As expected, Facebook today filed its own patent infringement lawsuit against Yahoo. The social networking giant is claiming the online giant infringes on 10 of its patents.
This is a countersuit and will likely lead to some sort of settlement between the two parties. Facebook says Yahoo is infringing on a wide range of its services, including its homepage, content optimization, relevance engine, Flickr photo-sharing service, and advertising throughout the service.
"From the outset, we said we would defend ourselves vigorously against Yahoo's lawsuit, and today we filed our answer as well as counter-claims against Yahoo for infringing ten of Facebook’s patents," Ted Ullyot, General Counsel of Facebook, told AllThingsD. "While we are asserting patent claims of our own, we do so in response to Yahoo’s short-sighted decision to attack one of its partners and prioritize litigation over innovation."
Two months ago, Yahoo threatened Facebook with patent war. Last month, the online giant sued the social networking giant over 10 patents and the technology industry made sure to criticize Yahoo like never before.
Some said Facebook should just buy Yahoo. Others argued Microsoft should come to Facebook's rescue. A recent rumor, however, pointed to Facebook fighting back by itself, and that appears to be exactly what the social networking giant is doing.
When Facebook amended its IPO filing the second time last month, the company briefly mentioned its potential legal battle with Yahoo. This was soon after Menlo Park received a letter from Sunnyvale, but still before Yahoo's lawsuit was filed. Last week, Facebook amended its IPO filing a third time, adding information about Yahoo's lawsuit. Today I can safely say: "Here comes amendment number four!"
Facebook has been bulking its patent portfolio, but the biggest purchase came after Yahoo filed its lawsuit. By my last count, the company has 812 patents. This includes 750 patents purchased from IBM, some of which Yahoo is rumored to have been licensing from IBM. | 2019-04-23T12:16:30Z | null | 590.3 | 2,223 | null | 0.239316 | [
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The most important part is of course just getting started talking about it. I saw an ad in a magazine from GamePlan Financial Marketing, LLC. It said, “Women can no longer afford to take a back seat in the decisions surrounding their retirement planning”. They are right. As women we often look to our spouses or other people for guidance which is fine but as we plan we should selfishly also look at what happens when we are alone. As the plan begins to take shape we need to be invested right from the get go for it’s all about our tomorrows. Just as you run your business developing a strategic plan, a marketing plan, and a budget. So the personal plan for retirement planning, saving and investing along the way is a bigger plan and without it you are just rolling the dice and speculating on what might be. | 2019-04-18T14:59:56Z | null | 331 | 812 | null | 0 | [] | [] | true | [] |
Whether you're thinking about extending your home with a new beautiful conservatory or improving it with replacement double glazing windows and doors, it is essential that you view the products before you buy.
We at Elizabethan would like to invite you to visit our Showcentre in Gwersyllt to see the quality and value for money for yourself.
There's no need to worry about the weather when you arrive as we have both an inside and outside conservatory showcentre where you’ll find a huge range of beautifully fully furnished conservatories in various styles and colours, giving you the chance to “try before you buy”.
We now have eleven full size conservatories on display including a new solid roof design.
View our range of PVCu windows, in various styles and finishes including bay windows, bow windows and sliding sash windows and see just how we can enhance the appearance of your home.
The selection of PVCu and composite style doors in our showroom are designed to provide a stylish and secure entrance to your home.
When you do visit our showroom, you don’t need to worry about aggressive sales techniques, we won’t hassle you as soon as you step through the door.
At Elizabethan, we understand that you might want to wander around at your leisure, although an experienced representative is always on hand if you require help and advice. | 2019-04-20T20:09:15Z | null | 327.8 | 1,346 | null | 0 | [] | [] | true | [] |
Patrick Surgalski, The One Coming Closer (from the Series "The Hudson Valley Painters"), 2000; Etching, 4 1/2" x 6".
Patrick Surgalski, associate professor of printmaking and drawing in the School of Art and Design at San Jose State University, has collaborated, and kept company, with a number of distinguished poets—including Lawrence Ferlinghetti, Nils Peterson, and Robert Bly over the last several years. The lithographs and etchings that Surgalski creates juxtapose a poem with the artist’s own images on a single sheet on paper. | 2019-04-20T04:52:43Z | null | 289.3 | 535 | null | 0 | [] | [] | true | [] |
The merchandise display happens to be a special presentation of the products of a store that is used to attract and even entice consumers. The nature of these displays can vary between industries, but all merchandise displays will be based on various basic principles that were designed to help increase purchases. Yes, merchandise displays are a big part of the merchandising concept, which is there to help promote sales by coordinating market, sales strategies and advertising.
Allocate display space as per your customer needs and lifestyle .
Combine products as per utility like dresses with shoes and accessories.
Focus on little details when constructing or arranging display backgrounds. | 2019-04-25T14:21:31Z | null | 410 | 695 | null | 0.692086 | [
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you will get resort treatment at a non-resort cost!!
Join Rebecca Cypher, MSN, PNNP as PEC presents this core InPatient OB Review class. This course allows participants to update their clinical knowledge base, review key clinical care issues, and improve decision-making skills to enhance patient safety and improve outcomes! The content compliments NCC InPatient exam components and through a collaborative effort with NCC, accepted exam candidates can move directly from this review to on-site paper-pencil testing the following morning. (Must attend at least one day of class, to sit the exam as an accepted candidate).
Option to sit NCC InPatient OB exam on the third morning. You must register separately and at least 21 days prior to exam date. Click on the NCC Exam Registration tab on the website Home Page, and follow the instructions there.
* You must attend at least one day of class to take the NCC exam option on site.
*If you are choosing the convenience of taking the exam in a paper-pencil format on site, after the class, registration with NCC is $275 and there is a $25 test administration fee due to PEC (in addition to the NCC exam fee of $275; net savings to you, $25).
A reminder, our Seminars are "review" courses, and as such, they are fast-paced expecting to review rather than teach new concepts. We strongly suggest prior preparation. We suggest that you download the "Candidates Guide" from the NCC website and review the exam content areas, doing a self-assessment of your strengths and weaknesses to assist with your own focus in the seminar.
You may email PEC if you want further directives: [email protected].
nor is PEC or its speakers aware of which areas are stressed in testing.
Group discounts are available for 4 registering together and there is a further discount for a group of 8. Group registration must be done at the same time. Get a group together: Save money, have some fun, and promote teamwork.
Please call 800-732-2387 for more information or to register your group. | 2019-04-23T20:53:07Z | null | 806 | 2,024 | null | 0.715909 | [
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I had the pleasure of working with Joe at ABMI. Joe works with a high degree of integrity and is absolutely committed to serving his clients with the utmost of care. He truly wants to serve his client’s best interest, respects the important nature of the transaction for the client and will work diligently to help them achieve the best results. Joe exhibits an entrepreneurial spirit that motivates others and help him to truly understand his clients. If you are a client seeking counsel on an exit strategy or assistance in selling your business, I would highly recommend Joe and ABMI.
I would recommend Joe and his team to anyone – with no reservations. He is a man of the highest integrity and business acumen. His team is the best in the business of “Selling Businesses”. They sold my Casino Company, Specialty House of Creation, in 6 weeks – had 4 buyers interested, and unlike most companies, Joe and his team do not work with the ‘self interest’ attitude that sours most business relationships. Instead he genuinely cares about everyone, from a truly kind point of view. Working with him was a great joy.
Joe is a close personal friend, who has mentored me throughout a number of successful businesses I have built over the past 20 years. Joe has an uncanny ability to think outside of the box. His brilliance in creating viable options that break through complex business challenges, has been a true blessing to me.
Joe brings a formidable combination of experience, creativity and passion to all he does.
I always enjoying my time brainstorming with Joe… I would highly recommend Joe for any endeavor.
Joe manages relationships in such a refreshing way in the world of deal-making. He not only exudes the utmost in ethics and character throughout each process, but has a tremendous passion for seeing clients satisfied with results. It has truly been a joy working with Joe at ABMI and he is an amazing leader for our company.
It is such a pleasure to have the opportunity to work with Joe. His commitment to his customers, employees, and business associates is truly admirable. Joe shows outstanding leadership through his passion for any endeavor he encounters, especially Vinco Partners, LLC.
If you are looking for the best results in any business venture, I highly recommend Joe for his experience, integrity, and passion. | 2019-04-24T18:55:56Z | null | 335.4 | 2,337 | null | 0 | [] | [] | true | [] |
The aim of this project was to document a collection specific to Florence. If you've spent any time in Florence, you know that there are a million and one of these religious vignettes stuck in alleyways, corners, and busy streets. Some are at eye-level and some are up to three-stories above street level. For me, the interesting part of these vignettes was the architectecture - some were very ornate and others starkly plain. My collection documented the architecture of a variety of styles of vignette and was presented in the form of a website. | 2019-04-24T04:08:11Z | null | 229 | 548 | null | 0 | [] | [] | true | [] |
Rotherham United have completed the emergency loan signing of Haris Vuckic from Newcastle United, subject to Football League and Premier League clearance.
Vuckic, 21, becomes the second signing of the day for Steve Evans’ side and the second to have joined from Premier League Newcastle, following the capture of defender James Tavernier this morning.
“This is a fantastic signing and he is a player we look forward to working with,” Steve Evans told www.themillers.co.uk.
The Slovenian international has represented the Magpies on 17 occasions, netting once after beginning his career with Slovenian Prva League outfit NK Domzale and played a part in Cardiff City’s Championship campaign back in 2012 during a loan spell. He has also found the net four times in the Premier Under 21 league.
If clearance is received, Haris be eligible to make his debut for the Millers in the Sky Bet League One clash with Gillingham this Saturday. | 2019-04-23T14:12:32Z | null | 457.9 | 932 | null | 0 | [] | [] | true | [] |
By the way, the ambassador falls into three categories. There are academic experts on japan, Secondly, political heavyweights. And last one is the personally appointed by the president. She falls into the last categories. I think many of Japanese think that she is great woman. Now japan and Korea talk about senkaku islands. I think it’s own japan, so this is not Korea I think. I want to them to get along with in the future.
this article is so helpfull for me to read, and it makes me try to read. cool.
As an Ambassador, is there something that, you being Japanese, would like Caroline Kennedy to do? | 2019-04-24T14:16:17Z | null | 360.5 | 604 | null | 0 | [] | [] | true | [] |
Funny Dodge Truck Jokes Funny ford jokes. Ford Truck vs Dodge Truck. Dodge Duck Dip Dive Dodge Imgur. FORD= Found on road dead HAHA Pinterest. Dodge Ram Pickup 2500 Review Research New & Used Dodge Ram. 2020 Trucks Chevy Ford Dodge.
funny ford jokes. Pin by Richard Jackson on Ram Tough Pinterest. Some people wanted a side shot of my 90 dodge ram they ask and. Chrysler January 2014 Sales Up 8 Percent Thanks to Strong Truck. Guys check your 4th injector line STICKY Page 26 Dodge. Dodge Trucks Dodge Trucks Pinterest. | 2019-04-25T23:40:29Z | null | 3,569.3 | 519 | null | 0 | [] | [] | true | [] |
Most of our products come with FREE 1-year Warranty, which comes "in the box" with nearly every product we offer! This means your purchase is automatically protected for a minimum of one year. And if your manufacturer's original warranty is for more than 1 year, our warranty won't adversely affect it.
You can always speak with a member of our in house Tech Support team during normal working hours by calling +6 03-8957 3850.
When it comes to service, you'll be glad you have Vbizz on your side. Most other music retailers don't even offer service, and merely ship your unit back to the factory. We have an on-site service department! Our entire staff of installation technicians, operational experts, and factory-authorized service techs are ready to help you. If there's something a manufacturer insists upon repairing themselves, send it to us and we'll deal with the factory. Of course, always remember to talk to your Sales Engineer. Their specialty is to find ways to keep you working if your gear does need repair. | 2019-04-19T05:01:53Z | null | 572.7 | 1,023 | null | 0.247312 | [
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Eksempler med tilsvarende betydning Was all in at the end of the day.
So beat I could flop down and go to sleep anywhere.
Bushed after all that exercise.
I'm dead after that long trip.
Eksempler med tilsvarende betydning He could feel the beat of her heart.
Eksempler med tilsvarende betydning The piece has a fast rhythm.
The conductor set the beat.
Eksempler med tilsvarende betydning He heard the beat of a drum.
Eksempler med tilsvarende betydning The cox raised the beat.
Eksempler med tilsvarende betydning The signal was two beats on the steam pipe.
Eksempler med tilsvarende betydning Agassi beat Becker in the tennis championship.
Harvard defeated Yale in the last football game.
Eksempler med tilsvarende betydning Thugs beat him up when he walked down the street late at night.
The teacher used to beat the students.
Eksempler med tilsvarende betydning Beat on the door.
Beat the table with his shoe.
Eksempler med tilsvarende betydning Her heart was beating fast.
Eksempler med tilsvarende betydning Beat swords into ploughshares.
Eksempler med tilsvarende betydning Rain drummed against the windshield.
The drums beat all night.
Eksempler med tilsvarende betydning The sun was beating down on us.
Eksempler med tilsvarende betydning The bird flapped its wings.
The eagle beat its wings and soared high into the sky.
Eksempler med tilsvarende betydning The boat beat in the strong wind.
Eksempler med tilsvarende betydning Beat the egg whites.
Eksempler med tilsvarende betydning Beat one's breast.
Eksempler med tilsvarende betydning Reading beats watching television.
Eksempler med tilsvarende betydning Beat the subway fare.
Eksempler med tilsvarende betydning The clocks were ticking.
The grandfather clock beat midnight.
Eksempler med tilsvarende betydning The bird's wings were flapping.
Eksempler med tilsvarende betydning Beat the rhythm.
Eksempler med tilsvarende betydning The city pulsated with music and excitement.
Eksempler med tilsvarende betydning Beat a path through the forest.
Eksempler med tilsvarende betydning Beat the drum.
Eksempler med tilsvarende betydning I beat the traffic.
Eksempler med tilsvarende betydning This beats me!.
Got me--I don't know the answer!.
This question really stuck me.
Eksempler med tilsvarende betydning This kind of work exhausts me.
He was all washed up after the exam. | 2019-04-21T02:23:21Z | null | 1,569.9 | 2,335 | null | 0 | [] | [] | true | [] |
Wow!!!! What an amazing bible study!!!!
Good Morning Divas! Our God is amazing and merciful. The prayer said in faith has power! Fill up your faith tank ladies, take God at His Word. He is faithful, He is good. He is our deliverer, our sustainer. He is faithful to His Word and it is does not return to Him void. Reach out and grasp the healing He has for You, in, through, and beyond anything this world has to offer you. | 2019-04-19T17:26:02Z | null | 993 | 422 | null | 0 | [] | [] | true | [] |
Great news for Wheat Ridge!
Looking for Wheat Ridge Internet service providers? Wheat Ridge locals choose Comcast. Change the way you WiFi with Xfinity xFi. Get the speeds, coverage, and control you need to enjoy the ultimate home WiFi experience. Wheat Ridge high-speed Internet fans can now enjoy consistently fast speeds even during peak hours, when everyone’s online enjoying high-speed Internet.
Wheat Ridge residents, listen up! Comcast delivers the high-speed Internet Wheat Ridge, CO has been waiting for. Get Xfinity Internet today!
In the Wheat Ridge, Colorado area, Xfinity Internet service from Comcast gives you reliably fast download speeds when you need them most.
Wheat Ridge Internet customers enjoy everything the Web has to offer with Xfinity service, including downloading HD movies, uploading photos, streaming TV shows or simply surfing for fun.
Great news for fans of fast Internet! Wheat Ridge, Colorado hotspots are better than ever! Wheat Ridge hotspots users on the go now have access to reliable WiFi hotspots from Xfinity all around the city. | 2019-04-25T06:01:56Z | null | 1,243.3 | 1,071 | null | 0.733894 | [
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The PP1 Tactiacal comes in OD green with a G10 Handle and a reversible pocket clip. It has a carbide and ceramic sharpening slots, along with a tungsten carbide glass breaker. It also comes with a diamond coated sharpening rod and lanyard hole. | 2019-04-21T02:22:16Z | null | 440 | 244 | null | 0.868852 | [
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100,000 products milestone reached in digital online and app-based Sweets product data for the AEC industry.
Sweets, Dodge Data & Analytics interactive building product database—located here—now provides free access to updated metadata on over 100,000 products for AEC professionals researching, comparing, selecting, and installing commercial products for buildings, structures, and building sites.
The longtime global leader in building products data, Sweets offers the most comprehensive building product information resource in the industry, says the company. Fully accessible online and via workflow integrations solutions through Sweets apps for Autodesk Revit and Autodesk AutoCAD.
Architosh has previously written about the new Sweets app for integration with BIM and CAD platforms used in AEC. Architects from top firms from Gensler, Perkins + Will, HOK, Perkins Eastman, Jacobs and more access Sweets and Sweets app for Revit and AutoCAD every month.
Over 300,000 registered users access Sweets gaining access to major brands such as Allegion, Nystrom, Sloan, Armstrong, and CertainTeed.
To further the exchange of information, ideas, and content among architects, general contractors, subcontractors, and building product manufacturers, Sweets has created a LinkedIn page, providing an active forum for the construction industry.
To learn more about Sweets online and Sweets app visit here. | 2019-04-25T01:17:12Z | null | 611.1 | 1,401 | null | 0.231977 | [
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One of the reasons I’ve always been attracted to technology is because I’m inherently lazy. I really get my kicks when the computer can do all the work for me. I can recall way back when, making the move from DOS to Windows programs, and how excited I was that we could now CUT and PASTE data from one program to another, instead of having to re-key everything. Heaven!
Of course, database programs have come a long way since then, and now feature all kinds of automation tools that help eliminate mundane tasks. Two of the more important functions in most modern association management software (AMS) packages are workflow automation and scheduled tasks.
In a nutshell, workflow automation is programming that has the database execute one or more additional steps automatically, based on what just happened in the database. For example, a common workflow that most of us now take for granted is automated emails when a customer (or staff member) processes an order in the AMS. A customer goes online, registers herself for a meeting, and as soon as that order is saved, the system sends an email (or two) confirming the order and providing additional details about the event. Customer automatically receives the email and no staff intervention is required.
But these days, workflow automation can do so much more. Beyond kicking off immediate email confirmations, workflow automation can also set up reminders for staff, create new records within the database, and even set reminder emails to be sent days, weeks, or months later. For example, suppose you track incoming inquiries about your upcoming annual conference. A workflow could be set up within your database such that when the inquiry is captured in your database, the system automatically creates a tickler task assigned to key staff within your association, and schedules an email to the person inquiring, to be sent automatically one week before the event takes place.
Most off-the-shelf AMS packages provide some type of workflow automation, and some even provide tools for staff to create workflow automations in-house (i.e., without the time and expense required of vendor intervention).
Another automation tool that most AMS packages have built-in are scheduled tasks. Scheduled tasks are generally some type of query that is designed to run automatically in order to check and/or correct data within the databases. Automated tasks could be as simple as automatically running a nightly query of all new members who have joined in the previous day, and delivering that report to your email box. A more advanced query might check for obviously erroneous data and correct that data automatically, and deliver a report to your email box outlining what was updated.
At the National Rural Electric Cooperative Association, John Conner, Applications and Data Advisor, uses a wide variety of scheduled tasks. One task simply runs through the database every night and checks to make sure there is a period after the middle initial in every name in the database. If a period is missing, the task automatically updates that piece of data.
Another much more advanced task, run on a daily basis, reviews all certification information and updates certification points based on participation data that has been entered in the past day. In both cases, the scheduled task takes care of very mundane tasks that used to require human intervention but no longer do.
If you have an off-the-shelf AMS (or even custom tool supported by programming experts), ask your vendor about automated workflow and scheduled tasks. You may be able to identify and automate processes that staff is currently handling manually, thus freeing them up for higher value activities. | 2019-04-25T22:16:38Z | null | 354 | 3,708 | null | 0 | [] | [] | true | [] |
Are you expecting a bundle of joy in the near future? If you are pregnant and getting closer to your due date, then this is a great time to schedule a maternity photo shoot. Your growing belly is a sign of your growing family. This special time in your life is a great reason to get commemorative photos.
When considering your photo wardrobe, it is important to find something comfortable and suitable for the occasion. We want you and your baby-bump to be the center of attention. So wearing heavy or bulky clothing that hides your pregnancy may not be the best idea. Here are some helpful tips on what to wear for your maternity photo session.
It’s not every day that we want our bellies to be the focal point of our photos. But during pregnancy, especially the third trimester, your round tummy is the heart of the show. You can really show off your pregnancy with form-fitting dresses and shirts. It’s important to make sure your clothing isn’t too tight or uncomfortable. We want you and your baby to be as safe as possible, and for you to be able to move easily throughout your photo session. But wearing something that conforms to the shape of your belly will result in amazing maternity photos. Tighter clothing will also allow for more variety in possible poses. If you wear loose clothing, then you may feel obligated to use your hands to show off the shape of your bump. That means most of your photos will be of your hands below your belly and your arms blocking the side of your bump.
If you do want to wear something loose to match an ethereal theme, then consider wearing a loose and shear outfit. That way, we can see through your flowing clothes and still see the outline of your belly. Or perhaps you want to wear something with a cut-out for your tummy. Then your clothing will look flowing and loose, but your belly will still be on display.
We understand that your body goes through a lot of changes during pregnancy. Showing off your growing belly does not necessarily mean you want to show off your entire body. If you would like to stay modest, then a button-down shirt may be an optimal choice for you. This will allow you to stay buttoned at the top of your shirt, and unbuttoned around your belly. Then it would be your choice to show off your belly or wear a form-fitting tank-top underneath. You may also want to consider a maternity dress that has sleeves. Sleeves, whether they are short or long, tend to be more flattering and the number one choice for expectant mothers.
The choice is ultimately yours! We want you to feel comfortable in your own skin, whether you want to be more or less covered up than usual. So take time to find an outfit that you feel good in. When you look good, you feel good. This will result in the best possible photos as you feel happy and beautiful in the clothing that you chose.
Finding a dress with a cinched waist, or adding a belt to your outfit, will really accentuate your baby-bump. It’s one thing to find a form-fitting top, but it’s another thing to make the most of your outfit with a cinched waist. As you’ve probably noticed from experimenting with your own maternity wardrobe over the past several months, adding a belt can make a considerable difference. Your belly will definitely pop if you find a cinched waist or belt to round out your overall look.
Some other baby-sized details to consider adding to your maternity wardrobe is ruching and layers. Choosing a dress or shirt with ruching at the sides can really define your belly. It will also allow for more space for baby, which will make both of you more comfortable. Adding layers to your outfit will also accommodate for the most comfort. Whether you have your photos taken inside or outside, we want you to be prepared to add or remove layers based on how hot or cold you feel. Layers are a great way to vary your look throughout the session as well, without doing a complete wardrobe change.
Your comfort and safety is of the utmost importance to us, and we want you to feel great during your photo session. So give us a call today to schedule your maternity session, and we will work hard to capture the beauty of your maternal journey beginning. | 2019-04-18T10:48:34Z | null | 407.9 | 4,185 | null | 0 | [] | [] | true | [] |
Kevin Davies received his Ph.D. in Leadership of Higher Education from Capella University, his MBA from Rockford College, MS in School Business Management and BS in Communications from the University of Wisconsin. Before entering academia, he held various mid to upper level management positions with Harlem and Dundee Schools, City of Beloit, Blackhawk Technical College, American InterContinental University and Credit Union Executives Society. He has designed, developed and delivered business courses in doctorate, graduate and undergraduate programs as well as partnered on executive education programs with world-class universities. Currently, he is a board development consultant for associations and not-for-profits, as well as contingent faculty for Walden University in addition to volunteering for Boy Scouts, Church committees, the school district, and various boards. He also serves as a national reviewer for the American Council on Education (ACE) and ACBSP accreditation. His most recent community project is working with my son to establish zoning ordinances to allow for the placement of Little Free Libraries to serve the disadvantaged (Boy Scouts will build and install). Dr. Davies has research interests in not-for-profit board development, financial cooperative models (credit unions), change management, and retention issues. He has presented studies and authored numerous articles. | 2019-04-21T14:04:49Z | null | 204.2 | 1,406 | null | 0 | [] | [] | true | [] |
HOW DOES WE DO SEO DIFFERENTLY ?
If you think unnatural backlinks are causing your rankings to drop, or you’d just like to ensure that you’re in the clear, we’ll analyze the links pointing to your website, and take action as necessary.
Local SEO is on the rise, and is, therefore, extremely important, especially if you have one or more brick-and-mortar locations. To serve up the most relevant information, Google considers geographic location when users perform searches.
Track your search rankings across more than 120 countries and regions, including their unique end-user filters and controls that restrict results by country and language.
Tashfier runs the queries for you without risk to your own local IP address so you can run as many reports as you need as often as you want.
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I would like to take this opportunity to share my experience in dealing with your company and to express my opinion of our project manager. | 2019-04-19T11:12:01Z | null | 376.9 | 1,241 | null | 0.650282 | [
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An incredibly slick, ultra long lasting lube made from a slippery blend of premium silicone, System Jo's Personal Lubricant definitely won't disappoint seekers of marathon-worthy moisture.
Silicone lube is extremely long lasting, and perfect for use in and under water, since it won't dissolve or wash away- it's also ideal for skin to skin contact, masturbation and use with most toy materials (excluding other silicone products).
A small amount will last through playtime with no need to re-apply. | 2019-04-23T18:00:56Z | null | 456.5 | 499 | null | 1 | [
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The Psychology BSc (Hons) is suitable for students with a science or commerce background who are interested in the systematic study of cognition, mind and behaviour. Students may wish to take this knowledge into a career in industry or complete further training to become a professional psychologist.
Why study Psychology at Heriot-Watt University's Dubai Campus?
Heriot-Watt psychology programmes have been ranked as one of the leading programmes in the UK.
Heriot-Watt takes an applied focus, going beyond textbook and theory to explore real-world uses of psychology.
Psychology graduates have sought after transferable skills in writing, research and critical evaluation.
Honours graduates have career opportunities in psychology and business professions and are eligible for a broad range of postgraduate training programmes internationally that are relevant to psychology.
The Dubai Campus is accredited by the Knowledge and Human Development Authority (KHDA) and fully licensed to teach its degrees in Dubai. All graduates receive a British degree that is accredited by Royal Charter in the UK.
This programme includes courses in psychological science, both theoretical and research based. In years 1-3 this is complemented by a small number of electives taken from the management programmes to broaden the learning experience. The curriculum is based on that recommended by the British Psychological Society.
Students are introduced to psychology from a range of perspectives and begin their studies in research methods, which will continue throughout the programme. Students are also introduced to the specific academic skills required to study and think about psychological contexts.
Psychology courses cover Social Psychology, Cognitive Psychology, Developmental Psychology, and Intelligence alongside more advanced Statistics and Research Design. Students also choose 2 electives in related management subjects, either human resources or marketing.
Psychology courses cover Social Cognition, Personality, Lifespan Development, Health and Forensic Psychology, and Biological Psychology. These courses take an applied approach, including the discussion of relationships, health and environmental design. Students also take 2 electives in management.
Advanced psychology courses continue the applied focus in a range of areas based on faculty expertise. Currently, this includes topics on consciousness, neuroscience, industrial psychology and psychopathology. In addition, each student undertakes a major independent project. This involves research design, data collection and analysis, and is a chance to learn in depth about a topic of the student’s own choosing.
Honours graduates have a wide range of career opportunities in both psychology and business professions and are eligible for a broad range of postgraduate training prorgrammes relevant to psychology internationally. Heriot-Watt Psychology has a highly active extra-curricular psychology programme to enhance students experience and involvement in the field.
Graduates of this Honours programme (4 years) will be well prepared for many areas of employment, including business management, human resource management, marketing and market research, teaching, counselling and coaching. Students wishing to continue into licensed psychology professions (such as clinical, forensic, health or educational psychology) will be eligible for the relevant postgraduate training at Heriot-Watt and at other UK institutions or internationally implement and maintain secure infrastructures.
Where English was not the medium of instruction at secondary school, applicants must demonstrate English language proficiency equivalent to IELTS 6.0 Academic (with no element below 5.5).
See our range of degree entry, undergraduate, postgraduate taught and PhD scholarships and discounts.
Follow Heriot-Watt University's Dubai Campus on Facebook. | 2019-04-19T18:32:15Z | null | 316.2 | 3,898 | null | 0.090303 | [
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Thank you for choosing Better Brella. We are dedicated to your satisfaction and for your convenience, we have provided this Site Map. If you should have any questions or comments, please feel free to visit our Customer Service Page. Thank You! | 2019-04-19T20:26:23Z | null | 992.7 | 243 | null | 0.868313 | [
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Want to be notified of new releases in cdbkr/go-question-and-answer-ibm-watson-bluemix?
Create your IBM Bluemix account and create a new app with custom buildpack. Once everything set up, a hub.jazz.net account should be created using Bluemix App Dashboard.
Once a hub.jazz.net repository has been created and connected, it's possible to push the code in and go through the staging process automatically. | 2019-04-22T13:59:41Z | null | 727.5 | 404 | null | 0 | [] | [] | true | [] |
At what % o2 should a reg be O2 clean I am looking at deco'ing on 60% but dont want to O2 clean a reg. Is it safe?
FS - Whites Aquapro shell drysuit. | 2019-04-25T18:40:17Z | null | 3,232.6 | 149 | null | 0 | [] | [] | true | [] |
Cdbf dbf viewer and editor crack. GUI version of CDBF for Windows is a powerful dbf viewer and editor that lets individuals and business users access dbf files directly without programming via the GUI version of CDBF for Windows is a powerful dbf viewer and editor that lets individuals and business users access dbf files directly without programming via the How to Use Dbf Viewer Editor. Filtering your Dbf Files. Filter. DBFView lets you filter dbf files according to specific criteria. Any data not matching the CDBF - DBF Viewer and Editor La versión con interfaz gráfica de CDBF para Windows es un poderoso visualizador y editor de archivos en formato DBF, tanto para DBF / FoxPro tools: DBF viewer and editor, DBF repair, DBF converters. DBF Viewer for Clipper, dBase, FoxPro dbf files CDBF - DBF Viewer and Editor gratis. Descarga la última versión de CDBF - DBF Viewer and Editor gratis: Permite editar y visualizar DBF fácil y rápidamente. dbf database viewer Información general DBF Viewer & Editor es una herramienta compacta pero de gran alcance para ver, editar e imprimir bases de datos en formato DBF. The access to our data base is fast and free, enjoy. All PAL region has different codes from the NTSC version of Guitar Hero 2. com How to Get Age of Empires Online Keygen Free By Age of Empires Cdbf dbf viewer and editor crack Crack by SKIDROW 4 download locations Download Direct Age of Empires Online Crack by SKIDROW Sponsored Link torrenthound. Date Name Drive Vaccine PC Restore Plus returned 5 download A serial can also be referred to as a CD Key. Trainer Title Need for Speed Pro Street v1. All All Audio Editors Audio … DriverXP For ATI Radeon 9250 Windows 7 Version Update your Windows 7 drivers for your ATI Radeon 9250 see Action Replay Codes for more The Legendary Starfy The Legendary Starfy for Nintendo DS Cheats - IGN has all the codes, cheat codes, unlockables, easter eggs, achievements, hints, tips and secrets For The Legendary Starfy on the DS, GameFAQs has 6 cheat codes and secrets. Total Front cover illustration of a young girl square feet two coats, depending telecharger crack cybercafepro 5 server surface. The older patches can be found here. Windows XP Driver Versions Ethernet Driver (v67. Audio/Video Business Desktop Developer Tools Drivers Games Graphics. Home/Education Internet ScreenSavers Programming Security/Privacy Utilities. | 2019-04-22T14:41:55Z | null | 1,985.8 | 2,386 | null | 0.254401 | [
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As he was returning, some of the enemy attacked him and caused him trouble, whereupon, becoming1 angry, he ordered the cavalry to charge upon them at full speed, and the infantrymen within ten years of military age2 to follow the cavalry; while he himself with the rest of his troops came along in the rear. And they killed nearly thirty of the enemy's light troops and pursued the rest to the theatre in Piraeus.
2 I.e. the youngest ten year-classes, each year-class including those who reached military age (I.e., the age of 20) in the same year. | 2019-04-21T05:14:19Z | null | 264.8 | 549 | null | 0 | [] | [] | true | [] |
Strategizing and implementing a marketing plan that is effective and professional, while also compliant with any state regulatory guidelines is crucial. Derek Gumin of CannaHost has been at the forefront cannabis marketing in Nevada since 2014.
With a reliable and extensive track record of industry standard setting creative vision, marketing techniques, and quality content within niche markets- CannaHost can bring your vision to fruition. | 2019-04-21T14:27:03Z | null | 1,007.2 | 442 | null | 0 | [] | [] | true | [] |
I was asked to give a couple of talks this spring giving my perspective on the current state of technology in business. I always think the present is better understood by looking at the past, so I put together a presentation looking at a) how things have developed over the past 20 or so years (not coincidentally, the span of time I was involved with CIO Magazine), and b) the challenges and opportunities I see businesses in general and CIOs in particular facing during this tumultuous time. I've posted a version of this talk on Slideshare, complete with an audio narration. Please check it out and let me know if your view lines up with mine or how you see things differently.
Loss of any kind messes with your sense of well being. Job loss, loss of a loved one, loss of health.... Having experienced a few of those myself recently (not my own health, thankfully), I've noticed some things I might not have paid much attention to in the past. There are little things that help to create a feeling of security when they are full or empty.
I knew someone once whose mother raised seven children on her own, after her husband developed multiple sclerosis. She went back to school to get her teacher's degree, and during that time, the family lived on very little money. One of her "full" idiosyncrasies was she always bought a new container of salt when she went to the store. Her kitchen cabinet was always full, even if only with containers of salt.
The paradox of tough times is they usually call for dramatic measures, yet it's human nature to keep a low profile and avoid risk, both corporate and personal. This is the dilemma facing CIOs today.
As I wrote in a column a few months ago, incrementalism won't cut it for many businesses in this economy. But according to Paul Gaffney, former CIO and head of supply chain at Staples and current COO of Desktone, that's the path most CIOs will take. | 2019-04-25T12:50:38Z | null | 277.9 | 1,901 | null | 0 | [] | [] | true | [] |
Since 2010, fit father NOAH MORRELL has trained for and ran the Navy 10 Nautical Miler every year like a ritual, but his running career evolved in 2013. His partner, Montoyia, introduced him to the local running group Black Men Run (BMR). That’s when he began to get more serious. Black Men Run is a support group that encourages health and wellness among African American men by promoting a culture of running to stay fit. The group is open to men and women at beginner and advanced levels.
With encouragement from his running community, Noah tackled his first marathon in 2014 at the St. Jude Marathon. That race sparked his love of marathons, and the busy dad hasn’t stopped. To date, he has run seven marathons, five in 2016 alone. “I started a small running group in 2016, Run Less Run Better, to help hold me accountable for my marathon training,” Noah says.
His favorite race is the Publix Georgia Marathon but not for the course or a PR. Thrown off by the time zone difference, Noah arrived an hour late to a deserted start line. Still determined to run and with no on-course support for the first 13 miles, he used his GPS and followed a trail of discarded water bottles to catch up to the tail end of the runners. Several people encouraged him to quit and veer off for the half marathon, but Noah persisted and is proud that he accomplished it.
Noah’s training schedule includes three runs per week—speed work on the track, a pace run, and a distance run on Saturday mornings. Twice per month he joins BMR for his long run, and he cross-trains one day a week either cycling or doing classes at the Desoto Athletic Club. “Cycling has really helped with my endurance and has been key to my marathon training,” he says.
With five children from age 14-25, Noah says part of the reason he runs is to be able to be around longer for them and his grandson. With a second shift job and a small business he owns on the side, he runs early in the mornings so that he can spend the day with his family. Both of his sons are also going to the state championship for track this year, and he likes to set a good example for them. “I encourage my kids to be better and faster than their dad,” he says.
By Christin Yates. Photo by Philip Murphy. | 2019-04-19T22:38:34Z | null | 520.5 | 2,239 | null | 0.048236 | [
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"He who has seen me has seen the Father"
We often call the great works Jesus did miracles. His promise that "greater works" would flow from our lives can easily cause stress when we see no such works. Then it is easy to either abandon the possibility of miracles altogether (rationalizing that their era has passed and thus our signless lives are the normal Christian experience) or to beg God for miracles (interpreting their presence or absence as indicators of God's approval or disapproval of us).
"The greatest danger in seeking miracles outside of God's will is that we become intrigued by miracles themselves and thereby disregard the One who did the miracle in the first place.
Another danger arises in seeking miracles that are outside of God's purpose. God knows what we need before we do, and he likewise knows when we need a miracle. Our first responsibility is to seek God's will.
Knowing God's faithful care for us is sufficient reason for gratitude, whether we ever see a special miracle or not, God is already watching over us, and he is already providing for us in countless ways we do not see. If the Shepherd never leaves us and never fails to give us our daily bread to eat, and if he always provides us with the water of life to drink so that our thirst is forever gone, why should we ask for more? John 6:35." - Steven Stiles, Journey on the Hard Side of Miracles, pp. 152, 153.
PRAYER: Dear God help me to be available for You to do whatever is Your will in my life, whether through natural or miraculous means. Amen.
"I have come to believe that those special miracles that shake our preconceived realities, and even those quiet miracles we may see day by day, are not for entertainment purposes. They are memories to be cherished, lessons to be learned, and counsel to receive.
They cause our knees to bend and our hearts to yield. They are a privilege to see, and they tell us, sometimes when we need to hear it most, that nothing can or ever will happen in our lives unless it is allowed by the Good Shepherd." - Steven Stiles, p. 10 (emphasis added).
"His miracles are not designed in the way that we might ever think to put them together. They are not always designed for us to understand. They are designed to teach us to trust him" - Steven Stiles, p. 124 (emphasis added). | 2019-04-26T06:08:15Z | null | 416 | 2,304 | null | 0 | [] | [] | true | [] |
Business roofing for sloped roofs are asphalt shingle, clay tile, concrete tile, metal shingle or panel and for steeper roofs slate. Roofing for flat or nearly flat roofs are EDPM (rubber membrane), TPO (single-ply rubber like membrane), Tar and Gravel, Modified Bitumen and Polyurea Liquid Waterproof Coating.
All Roofing systems have a specified installation protocol provided by the manufacturer and add to that government regulations and building codes. We carefully follow each instruction and regulation. You will not get a hurried incompetent roofing system install from us as evidenced by our previous client reviews. We also keep ourselves updated on Roofing industry advances that may benefit our clients or provide better protection for our employees.
There are so many types of roofing choices available today that it is hard to know which are the best choices for your situation. A trustworthy Commercial Roofing Contractor knowledgeable enough to explain the positives and constraints of each type of roofing systems is very helpful to clients trying to wade through so much information. VA Commercial Roofers have 3 generations of experience to rely on and we gladly offer free advice- just contact us for a consultation.
Industrial Roofing is used for manufacturing buildings or complexes. Industrial roofing needs to be strong as these roofs undergo more stresses copping with the byproducts of manufacturing, such as increased heat output through chimneys, fumes from chemical reactions, hot steam release from product ovens, and should have strong roof support for filtering equipment on the rooftop treating the manufacturing exhaust- so only treated air is allowed to flow into the atmosphere.
Many Industrial roofs will have designed walkways to help provide service personal a safe walking path to rooftop equipment. These companies will most often place sacrificial membrane on these paths to be replaced as they wear down- a good solution to sometimes careless service personal that may drag repair equipment across the rooftop.
Industrial roofs need drainage systems that will handled a large downpour without developing a pond on top of the roof- this is not often addressed well during planning which is why getting advice from an experienced commercial roofer is so important to the longevity of the roofing system.
Most clients are concerned with the quality of the asphalt shingle they want to use; however, the asphalt roofing system is comprised of many components. There is the roof decking, ice shield for protection against ice dams, water-resistant underlayment, skylights, ventilation of the attic, flashings around vents all roof openings and proper treatment of peaks and valleys. You could pay a lot of money and order 50-year shingles with the thought your roof will last 50 years- you could be very disappointed. If just one of the other components to the roofing system is installed poorly, your roof is on borrowed time waiting for that final fault that penetrates the roof and allows moisture and critters in.
Asphalt is susceptible to decay with exposure to Ultra Violet light. To protect the shingle from sunlight, ceramic granules are embedded on the top and some shingles have copper or other bio-cides added to the surface to retard the growth of algae. The ceramic granules also protect the surface from impact.
3-Tab which are flat thin lengths of asphalt shingle that has 3-tab cut outs on a single long piece that gives the illusion of 3 separate tiles. Their manufacturer warranties run from 10 to 15 years.
Architectural or Dimensional shingles are thicker, stronger, come in various shapes and sizes, show up as 3-dimensional shadow effect on a roof and have longer manufacturer warranties mostly up to 30 years.
Premium Shingles most often are a replacement to the very expensive Luxury roofing tiles, such as cedar, slate and clay tile. They are rated for success with lifetime warranties.
Not only does metal roofing look good, it is environmentally friendly. Metal roofing production uses 25 to 95% recycled content (percentage depends on the type of metal), plus should these roofs ever need replacing they are 100% recyclable- nothing to wind up in a landfill.
Metal used in roofing are aluminum, galvanized steel, zinc, copper and tin roofing though tin is most often mixed or alloyed with other metals. There are some very poor metal choices available as roofing material but a way to steer clear of them is to make sure your roofing choice is tested and labeled by UL, FM or Global metal agencies.
Durability to wind gusts of up to 140 mph.
Energy efficiency- metal roofing reflects solar radiant heat and keep the building below cooler.
They are more expensive than Asphalt Roofing.
Without insulation they are noisy during heavy rain or hail.
As metal panels expand and contract with temperature change its special fasteners can become loose.
Slate roofing is the most expensive and elegant of all roofing types available. Slate is quarried from different parts of the nation usually from an ancient sea bed that has undergone pressure from two land masses meeting and pushing together which causes the foliation of the mud into slate, over eons, which allows it to split smoothly and easily. Slate comes in many colors gray, green, purple, black, red or mottled with swirls of several colors.
Slate roofing most often appears on historic, academic or cathedral type buildings. It has been used for roofing quite expansively since the 13th century so we know a lot about how best to install this material for maximum lifespan which is sometimes above 170 years.
Slate roofing is not an easy install because its tiles are fragile (can’t be dropped without breaking). Scaffolding must be used during installation as slate can’t be stepped or knelt on without damage to its structure. Fractures may not appear right away but years later because the fracture was internal as which point you have a leaking expensive to repair roof. It’s very important to hire an experienced slate roofer because of the artisan skill required to build it properly.
TPO Roofing is a single-ply heat sensitive membrane that consists of 3 layers. A woven web of polyester reinforced material sandwiched between a TPO polymer base and a top mineralized reflective surface.
TPO membrane was developed in the 1990s as a more affordable alternative to PVC membrane but with the same advantages. Advantages are: easy installations, heat sensitive to allow for hot welded strong seams, flexibility in breathing with the building below, reflective top for efficiency against solar gain and resistance to punctures, mold and dirt accumulation.
TPO roofs are very quick installs without the harsh smells that accompany the installs of other types of roofing, such as BUR.
We have been building Tar and Gravel Flat Roof Systems in America for 150 years so we know a lot about how to keep them going a long time.
These roofs are assembled on the rooftop, with alternating layers of liquid asphalt, spread by mop or special sprayer, and a felt or fabric mat most will choose between 3 and 4 BUR layers to be finally topped with a last layer of asphalt covered with smooth round gravel. The gravel top protects the asphalt from the degrading rays of the Sun, and it also protects against impacts of hail or blown on debris.
These are heavy roofs. The layer of gravel alone can be 5 to 10 pounds per square so the underlying roofing structure must withstand the weight. Plus, the roofs are difficult to find leaks without puling the gravel back to get a view of the membrane.
Modified Bitumen Roofing System is very similar to BUR except the membrane is already built- no layering on the rooftop is required. A reinforced fiberglass or polyester fiber mat is soaked in asphalt and then is topped with a mineral coating to add protection against the sun. The mineral layer acts as a gravel top to protect the asphalt in the membrane from sunlight and for impact protection so a gravel top is not necessary but is still sometimes used as ballast to weigh the membrane down against wind uplift.
Method of application is either a torch down method of using fire to melt the asphalt as its rolled out on the rooftop fully adhering it to the substrate or cold adhesives are used to fully adhere the membrane to the rooftop. Both methods apply rolls of membrane in an overlapping manner.
EDPM (ethylene propylene diene terpolymer) is a tough rubber like roofing membrane used for flat roofs across many industrial nations. Like much of the products used in the roofing industry its major ingredients are products produced with oil and natural gas.
The membrane comes in a large range of lengths with widths ranging from 7 ½ to 50 feet and in a thickness of 45 or 60 mils.
EDPM roof systems have an expected lifespan of 22 to 35 years (does depend somewhat on weather and upkeep).
EDPM membrane has 3 ways to install them.
With liquid adhesives- fully adhered.
Mechanically held down with special washers and screws.
Ballasted with a few inches of smooth round gravel.
Polyurea a durable and long-lasting coating that will reduce energy bills and seal tight against leaks around flashings that plague other flat roof systems- the coating can even withstand constant standing water.
The Polyurea coating also will resist corrosive chemical fallout that could be exhausted onto a roof’s surface from manufacturing processes taking place in the building below or from a neighboring building.
The spray can be formulated with non-fading UV colors (white is often used to reflect the UV rays back to the atmosphere to avoid heat transfer to the building below).
Its fast to set so the protected surface can return to service quickly. Very attractive to business applications that may find it costly to stop business for a few days under other types of roofing.
It can be successfully applied over numerous substrates concrete, metals, wood, stone, foam and others.
It can be applied in a wide range of temperatures and humidity levels and some types will even work on cold and damp surfaces. | 2019-04-19T02:56:50Z | null | 580.8 | 10,109 | null | 0.0826 | [
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ESSAY collections get a bad wrap. Too many of them are lazily assembled pieces to remind the public that the author still exists, or the work is so bland that it’s surprising it was ever published in a magazine, let alone now republished as a book. And then there are writers like Martin Amis or Joan Acocella whose collections remind us that literary journalism is alive and well. Acocella, the dance critic for the New Yorker, has put together her own greatest hits with “Twenty-Eight Artists and Two Saints” (Pantheon, $30). The saints are Mary Magdalene and Joan of Arc, while the artists range from a who’s who of writers (Sontag, Roth, Bellow) and dancers (Baryshnikov, Graham, Fosse). A particularly engrossing piece entwines her delight in Lucia Joyce, James Joyce’s troubled dancing daughter. At the heart of the book, she writes with all the grace of a ballerina in mid-twirl, which only adds to her pleasure and immediacy.
At the other end of the spectrum is a rushed biography of a president, suddenly remembered at his death. “Gerald R. Ford” (Times Books, $20) was written by Douglas Brinkley a historian as interested in his own media presence as he is his subjects. It was Brinkley who hogged the airwaves in the summer of 1999 – parlaying his connection to John F. Kennedy Jr. – into a marathon of talking-head punditry after the George editor’s death. He popped up again in 2004, with a well-timed biography of John Kerry’s war experience in Vietnam that read more like campaign literature. Here, he tackles the story told so many times in early January, when half the country was wondering why Ford’s presidency was suddenly significant, and why pundits all felt the need to talk about Ford as being a nice guy, as if that were the only qualification necessary. Ford was a president in much the same way that Brinkley is an academic. And in that sense, this book, an uninspired, apologetic retelling of a brief, accidental presidency (complete with exclusive interviews!) is precisely the biography that he deserved. | 2019-04-19T07:50:30Z | null | 298 | 2,035 | null | 0 | [] | [] | true | [] |
Since Singapore is quite developed and congested, considering maneuvering ability of commercial van for sale Singapore is also important. Vans taking turns on circles or how quickly a van can make U-turn are the things to keep in mind while buying a commercial van.
Before you buy a commercial van, you must take a long test drive, and notice if the van can squeeze in parking lots or in busy places. Most of the dealers may give you some ideas which are not applicable when it comes to reality. So contacting Goldbell will be an ideal thing to confirm the maneuver ability of the van. | 2019-04-21T16:03:47Z | null | 599.2 | 585 | null | 0 | [] | [] | true | [] |
The 243 meter long, 107507 dwt tanker Shah Deniz collided with the 225 meter long, 73603 dwt bulk freighter Ju Da on the Black Sea outside the port of Novorossiysk, Russia. The two vessels were struck by high winds when the Ju Da struck the Shah Deniz. Both vessels sustained some damage, but no reports of hull damage below the waterline. Reports state there has been some fuel pollution released. Both vessels were attempting to evade a severe storm in the area. No reports of injuries. Authorities have stated they will investigate into the incident.
The 115 meter long, 8214 dwt container ship Kota Duta collided with the 89 meter long, 2621 dwt freighter Tanya Karpinskaya in the port Niigata, Japan. The Kota Duta was leaving port when it struck the Tanya Karpinskaya which was heading to another part of the harbor. The collision resulted with the Tanya filling with water. All 17 crew on the Tanya Karpinskaya abandoned ship into the lifeboats and were later rescued by a harbour tug. The freighter later capsized and sank. Two crewmen suffered minor injuries. Reports state there was another crewman from Tanya who was on the Quay. Authorities have started an investigation into the incident.
The 88 meter long, 2734 dwt freighter Alaca 1 was crushed by ice in the Azov Sea near Kirillovka. The Alaca 1 became stuck in the ice while heading to Rostov-on-Don from Kerch and requested assistance from an icebreaker. While waiting for the icebreaker, the ice punctured the hull allowing water ingress. The crew of 12 on board abandoned the vessel and went onto the ice. When contact was lost with the Alaca 1, authorities dispatched a helicopter to the scene. The helicopter found the men and were able to safely rescue them. The crew were taken to Simferopol, Ukraine. No reports of injuries. The Alaca 1 was lasted reported drifting with the ice. Authorities are not certain if the freighter will roll over and sink or remain afloat. No details about the cargo or the amount of fuel on board. | 2019-04-23T19:28:24Z | null | 558.9 | 2,000 | null | 0 | [] | [] | true | [] |
Driving VW's take on the Outback formula.
VW always seems to be a bit late to the game. Next year, the German carmaker will bring the Alltrack model we’ve just driven to the U.S.; it’s a jacked-up Golf SportWagen fitted with all-wheel drive and off-road styling affectations. This comes almost two decades after the segment's role models, the Volvo XC70 and the Subaru Outback, first appeared. What most Americans don't know is that VW has been selling these sorts of Golfs since the early 1990s. But that era’s Golf Country was never sold in the States, and it was so funky looking that it would probably scare away the typical buyer of this Alltrack.
To compile this review, we sampled the European version of the Alltrack in Germany, where it is already available for order. Starting later in 2016, U.S.-bound models will be made in Mexico, where significant investment in VW’s Puebla plant was made to accommodate the assembly of all-wheel-drive vehicles.
Available only with 4MOTION all-wheel drive, the Alltrack moves a step beyond being a mere appearance package and offers some true capability. VW aimed to deliver greater efficiency by decoupling the rear axle from the driveline during everyday driving, meaning the car feels much like a typical front-wheel-drive Golf much of the time. If the traction of four driven wheels is needed, a Haldex clutch calls the rears to duty, and they can be sent almost 100 percent of the torque.
The driving-mode selector, which tweaks throttle and transmission parameters, among others, adds an "Off-Road" setting in the Alltrack. This enables hill-descent control and also lengthens the ABS pulses to allow gravel, dirt, or snow to pile up in front of the wheels to shorten the braking distance when decelerating hard on loose surfaces. The chassis is raised by 0.8 inch, which doesn’t sound like much but will come in handy on various two-tracks and dirt roads.
The aesthetic package brings restyled front and rear ends with aggressive fascias and fake skid plates. There are fender flares that VW claims are there for protection, but of course they are far too pretty to risk getting them scratched. Meanwhile, the 17- or 18-inch wheels look good, but those who actually wish to do some form of off-roading might have preferred a steel-wheel option, not to mention taller tire sidewalls, neither of which are available. Inside, the Alltrack is fitted with model-specific, but rather nondescript, fabric and trim. Otherwise it’s a Golf SportWagen, which means restrained, handsome good looks inside and out, plus a functional and ergonomically friendly dashboard layout. The Alltrack suffers from the same singular demerit we’ve found in its brethren, though, namely a slow and frustrating infotainment setup. Here’s hoping Volkswagen adds some processing power to the Golf line by the time the Alltrack arrives here.
Given all of the foregoing, you may expect that the Golf Alltrack also basically handles like any other Golf, and you’d be right. It offers a refinement beyond what can be reasonably expected in its segment, with a nice blend of compliant ride quality and capable, easily exploited handling. Despite the raised center of gravity, the Alltrack steers with precision, responds quickly to inputs, and hugs corners nearly as well as its comrades.
Better late than never, we say. The Golf SportWagen Alltrack is a welcome entry, and it could turn out to be a real headache for Subaru’s larger Outback models, as well as a number of duller crossover SUVs.
VW Confirms AWD Alltrack Wagon for the U.S.! | 2019-04-22T00:20:31Z | null | 363.5 | 3,561 | null | 0 | [] | [] | true | [] |
I'd like to build a UHF (~800 MHz) FM audio transmitter. I have no experience in electrical engineering but I study physics and I'd like to acquire practical experience in electronics. In fact my goal is (almost) entirely didactical, with the purpose of self-learning.
I suppose I will need an oscillator, an FM modulator (let's say I pick the audio signal from a computer through an audio cable, and not from a microphone) and some sort of antenna. I'm asking you how to build all these elements, possibly from scratch.
I guess the biggest problem would be the oscillator, because 800 MHz is really a high frequency and even the function generator we have in the laboratory isn't capable to produce such a signal. On the other hand computers and microprocessors have oscillators in the range of gigahertzes so it should not be an impossible task, either.
Then comes the antenna. In class we have learned about the dipole antenna, but I guess for my purposes I need another type of antennas. I'm saying this because the length of a dipole antenna should be the wavelength of the generated frequency, at least according to my textbook, and I see that the a UHF transmitter has an antenna shorter than 30 cm.
This is a very broad question and will probably be closed, so I'll only answer briefly.
Find something called a voltage controlled oscillator (VCO). There are probably some available in your frequency range.
As for the antenna, a dipole should be 1/2 wavelength, which is about 176 mm or 7 inches in your case.
You are better off buying a mini circuit VCO, a PLL chip, a ripple value crystal (10.24, 2.56,5.12MHz) as reference and a prescaler. You need op amps as summation amplifier network to combine audio and error voltage to the VCO, split the VCO output into two one goes to the prescaler and the other half to an amplifier (there are several in the market).
Personally I prefer MC145152 chips as they are parallel loaded(you can use switches) takes almost all dual modulus prescalers from any manufacturer and almost any ripple value crystal. it can be built in one hour.
Not the answer you're looking for? Browse other questions tagged rf radio oscillator antenna transmitter or ask your own question.
Make an RF transmitter: classic transistor oscillator or VCO module?
How to radiate a positive oscillating voltage? | 2019-04-21T22:44:05Z | null | 685.7 | 2,332 | null | 0 | [] | [] | true | [] |
Synthetic cannabinoids are not one drug. Hundreds of different synthetic cannabinoid chemicals are manufactured and sold. New ones with unknown health risks become available each year. Synthetic cannabinoids are popular because users often believe they are legal and relatively safe.
These chemicals are called cannabinoids because they act on the same brain cell receptors as tetrahydrocannabinol (THC), the main active ingredient in marijuana. However, the hundreds of known synthetic cannabinoid chemicals and THC are different chemicals. In fact, synthetic cannabinoids may affect the brain in different and unpredictable ways compared to marijuana.
Synthetic cannabinoids are widely available.
Many synthetic cannabinoids are illegal.
The federal government has banned many specific synthetic cannabinoids. Many state and local governments have passed their own laws targeting other synthetic cannabinoids.
Recent federal and state laws targeting synthetic cannabinoids have banned general categories of ingredients, rather than specific chemicals.
Synthetic cannabinoid products are unsafe. It is hard to know what the products contain or what your reaction to them will be.
There are no standards for making, packaging, or selling synthetic cannabinoid chemicals. That means that two packets of a brand-named product may have completely different chemicals.
The amount of the synthetic cannabinoid chemical(s) can vary between batches or even within the same batch.
Synthetic cannabinoid products may also be contaminated with other drugs or toxic chemicals, such as synthetic cathinones (“bath salts,” “flakka”).
Synthetic cannabinoids can harm your health.
Synthetic cannabinoids can cause severe illness and death.
These health problems depend on many factors, including the specific synthetic cannabinoid, the dose (how much), and the duration of use (for how long).
The long-term effects of long-term synthetic cannabinoid use are unknown.
Synthetic cannabinoids may be addictive, since some people have reported withdrawal symptoms after heavy use over a long time.
Experts think that the severity of these symptoms is related to how much synthetic cannabinoid is used and for how long.
If you or anyone you know becomes sick after using synthetic cannabinoids, seek immediate medical attention. Call 911 or go to the closest emergency room.
There is no specific antidote for synthetic cannabinoids, but health care professionals can provide supportive treatments, such as oxygen, intravenous fluids, and medications to control seizures, agitation, and nausea.
Use caution in handling these products If your work (such as law enforcement) involves handling synthetic cannabinoids, you can learn more about how to protect yourself from exposure by reading this reportCdc-pdf.
Learn more about synthetic cannabinoids.
If you have questions about synthetic cannabinoids, including whether or not to go to the emergency room, please call your healthcare professional or contact your local poison center by calling 1 800 222 1222. | 2019-04-18T14:27:58Z | null | 342.5 | 3,038 | null | 0.227123 | [
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The professionals at DJJCPA have a wide range of experience in the real estate industry. They will not only help you to grow your business but they are also able to put you in a place of strength, helping your business to sustain growth while responding to the industry’s opportunities and threats. DJJCPA offers traditional accounting, auditing, and tax services, along with management consulting services specifically designed to increase your profitability and reduce operating cost. | 2019-04-19T16:14:39Z | null | 300.1 | 486 | null | 0 | [] | [] | true | [] |
Part of the alliance shaman air totem quest. You have to climb the mountain north of Exodar to get here.
This npc is NOT in Exodar like quest helper says so just go to 26,26 and follow path you can't miss it.
I just followed the hills to the water, here is the beach where some murlocs dwell. Used my water walking to avoid bumpy terrain and found the small rounded penesula where the path starts not far from the water.
See the "O" on the map of Azuremyst Isle where THE EXODAR sign is? Go to the bottom of the "O", you'll see the path which leads up to her. After a while, you'll see torches, aspect of air along the road etc.
Her location does appear right in the Exodar on a two dimensional map, but she is actually above it in three dimensions. Ignore ignore her location coords. Use instead the location/coordinates of the path. If you hate coords, just find the Murloc village to the North of Exodar on Azuremyst Isle and take the coastline towards the west. You'll wander just a bit before encountering the pathway. The pathway is clearly marked with lit torches and involves several switchbacks strewn with level 40 air elementals.
The path to her and the surroundings are a great place for farming copper, as there's quite a couple of veins and abseloutely noone around.
First off the quest, Call of Air, is pretty vague in adiquetly telling the quester where the location of Velaada is.
She is deffinetly not in The Exodar and so a good way to find the path leading to her location within a cave is to head towards the "A" part of "The Exodar" on the Azuremyst Isle map, once you have reached the beach there turn left and continue past several small hills which may seem not trafersable, but which will eventually lead you to a rough dirt path heading up a steap hill, surrounded by the occasional air elemental and then eventually reaching a cave where you will find Velaada. | 2019-04-20T16:42:55Z | null | 690.3 | 1,888 | null | 0 | [] | [] | true | [] |
This language textbook is designed to give the reader a working knowledge of Russian within three months. It explains essential grammar in a simple and practical way, and provides short exercises and conversational drills. There is also a pack available, containing this book and an audio cassette.
3. Russian in Three Months (Hugo) Brown, Nicholas J. | 2019-04-26T10:30:18Z | null | 296.2 | 351 | null | 0.635328 | [
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OK, I'm Hooked!! I thought the Batman Statue was fine, This one blew my socks off!!! All the extra pieces give you an endless variety of possibilities for display. Love the light up eyes and how the AK helmet has a clear shield covering it. This one and the Batman are on both sides of my fireplace!
I just received my 2nd Arkham Knight Exclusive. There are NO words to express the Beauty and Quality detailed in this PIECE OF ART. I paired them with my pair of Prime 1's Batman Arkham Knights. Extraordinary ART for SURE!!! | 2019-04-24T22:20:08Z | null | 1,364.8 | 524 | null | 0 | [] | [] | true | [] |
Cover for hired-in plant equipment.
We offer standard cover for hired-in plant from £15,000 to £100,000 against theft, fire, storm, flood, water damage and malicious damage (see your policy for full details). Higher limits are available depending on requirements for your hired-in plant.
We can provide hired-in plant insurance for a variety of equipment including small portable tools, generators and larger items such as scissor lifts and cherry pickers. Our single article limit is from £2,000 upwards depending on the equipment.
If your hired-in plant suffers theft or damage, you will not be able to carry out your work but will still be liable for the hire costs. Hired-in plant insurance can cover leasing charges until the situation is resolved.
We can provide cover for single item hired-in plant, with an article limit from £2,000 upwards depending on equipment.
If and when it comes to the crunch and you need to make a claim, we have an in-house team who work hard to understand all the details of your claim then get these to the insurer to get your claim resolved as quickly as possible.
If there are any complications with your hired-in plant insurance claim, we’ll follow this up with the insurer and keep you updated with the progress of your claim.
Read tips and advice from our industry experts.
When you are an employer running your own organisation and taking responsibility for its success or failure, getting the right insurance cover for both your business and your workers is crucial.
Hired-in plant is any part of plant equipment that you are leasing in and responsible for.
Why do I need hired-in plant insurance?
When you lease a piece of plant, you enter into a contract with the hiring company which means you are responsible for the plant while in your control. Hired-in plant insurance provides peace of mind and protection against the risk of the plant being stolen or damaged. If one of these incidents occurred you would be legally liable to replace the plant, which you may not have the money to do.
What are hired-in charges and how are they calculated?
Hired-in charges are the annual cost of hire of a piece of plant from a leasing company. This annual hire-in charge will have an effect on the price of your premium, depending on how frequently you use the plant.
How much cover can you provide for hired-in plant against malicious damage, fire and theft?
We offer standard cover against malicious damage, fire and theft for hired-in plant from £15,000 to £100,000 through our panel of insurers. We can extend this limit with a tailored policy if you require a much higher limit.
If you would like to know more about our monthly payment option, please visit our dedicated Direct Debit page.
Not only do we offer hired-in plant insurance, we can also insure the following products. | 2019-04-23T08:35:40Z | null | 628.8 | 2,820 | null | 0.46773 | [
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It was a hilarious tune where he took the stories of Bob Dylan visiting a dying Woody Guthrie in the hospital and making up a fictional account of Bern sneaking into Bruce Springsteen’s home to have the same kind of visitation. Of course Springsteen isn’t on his death bed in the song and he kicks him out. That was my first impression of Bern, and I loved it.
From that time time to now Dan Bern has remained a relative unknown to most people. He got a bit of a bump a few years ago when he contributed to the songs written for the movie Walk Hard: The Dewey Cox Story (most notably “There’s a-Change a-Happenin’I Can Feel It”). He also penned a couple Aldous Snow songs for Get Him To The Greek.
After spending a few albums plugging in and rocking a bit more, Bern returns to his roots on Drifter, his first original full-length in three years. Needless to say he’s grown as a writer and performer in the decade since I first became aware of him.
In his earlier days Bern’s voice was a nasally whine. He played up all of his similarities to Dylan to great benefit. Sometime along the way he found his own way of singing and got a boost of confidence. His words are more pointed now instead of the sometimes meandering warble of his early records.
The song that popped for me the most in my initial spin of Drifter is “Carried Away.” It starts out like a Sticky Fingers-era Stones song, but only for the opening bars. After that it reminds me much more of Wilco somewhere between A.M. and Being There. It’s one of the few songs that features electric guitar heavily, but it’s absolutely integral here. This might be the most mainstream tune I’ve ever heard by Bern, but he doesn’t sacrifice writing quality to broaden the appeal.
As much as I love that song, I think that the duet with Emmylou Harris, “Swing Set,” is a bit of a missed opportunity. It’s a snoozy, contemplative ballad that thinks over a parent and child’s memories drifting away as the kid gets older and the relationship that was so close has become less important. Maybe it holds a deep meaning for Bern, but I didn’t really connect with it as written. Good vocal performances from Harris and Bern, but overall not a great song. A rare miss for Bern.
Luckily he redeems himself a couple songs later with “Mexican Vacation.” It’s a not quite post-apocalyptic tale of a dystopian future where the world is mostly underwater due to climate change. In the words, Bern creates a cinematic vision to behold. Cars underwater, acid rain in the hills of Pennsylvania, and mole people all make appearances. It’s his usual sly wit and picturesque storytelling that make a lot of his songs work, and this one is a great example of that.
I’m a fan of Drifter, but I think being a fan going in helps. If you listened to Dan Bern at the beginning of his career and didn’t follow him, I’d suggest giving him another shot. He’s matured greatly over the past decade, both in his writing and in his performance. The nasally young man just trying to get his voice heard is gone and in his place is a true wordsmith and troubadour.
Drifter was released on June 12th, and you can listen to the whole thing for free before purchasing on Bandcamp. His current tour dates are strictly east coast (he was just here in Chicago last month, I believe), but he’s basically been on tour for the past fifteen years so he’ll be making it to your neck of the woods sometime in the not too distant future, I’m sure.
I have been diggin’ Dan for many years and he’s gotten me to places with his songs I thought I would never go. Some days I feel old and ready to rot, while others, music gets me to be all the more with what I got. Dan’s one of those catalysts on a good day, a good night.
The title track is the one track on here from the Master inside him. I’m not slagging the disc but songs like “Swing Set” only hint at their greatness. I don’t throw around the word “genius” much… and Emmylou Harris only plays with the best so you figure it out.
Dan has a talent to tap into the universal poignancy of this life and bring us the gold that moments hold all around us day after day, if we’d only remember how to be free enough to feel – to see – what’s real. There are under five human beings on the planet doing what he’s doing now at his level at his best. I’m not one.
Precious little on this disc taps into that but for sure “Luke the Drifter” does. Live with that song a little – dance with it.
But I love the man as an artist and I feel guilty for not writing a Facebook-age “omg every song is genuis!” but just because he’s hit a single or a double doesn’t mean he’s not a homerun king of song. He is.
His canon – his great great canon – is respected treasure and if you don’t know it, neglected treasure – get out there and dig.
This new Drifter disc — some songs I’ve known for years, like “Party By Myself”, and are pretty solid but if you want an idea of what makes Dan great, listen to “Luke the Drifter” and “Swing Set” and then click around his YouTube catalogue for “Lithiuania”, “God Said No” and “Estelle”, among many, many others. And buy those songs. Support an artist with the heart of a lion and the imagination that makes up the sky. | 2019-04-23T10:47:19Z | null | 267.5 | 5,193 | null | 0 | [] | [] | true | [] |
The C-518AS features an innovative system for side mounted LEDs & a premium built-in diffusion that creates beautifully soft lighting. The bounced light produces a soft, even glow with no hotspots. It makes the light ideal for filling in shadows or using as an interview light.
The ultra thin design make it an ideal location light and the kit includes DV style batteries and a charger. For longer running times, you can attach larger V-Lock batteries to the supplied fixing plate, but these batteries are an optional accessory.
The colour temperature on the C-518AS is adjustable from 3200K to 5600K and this is controlled by a rotary knob at the rear of the light. Another rotary knob controls the dimmer and there is a backlit LCD panel that gives a read out of the colour temperature, dim range and an indicator for remaining battery life. | 2019-04-22T18:35:58Z | null | 816.1 | 843 | null | 0 | [] | [] | true | [] |
Rising Tide is a cooperatively owned business, governed by its member-owners. Rising Tide operates for the mutual benefit of all member-owners. When people need something they can’t get easily or at a reasonable cost, they can start a co-op to get it. Cooperation is a powerful tool to help communities meet local needs.
Co-ops cultivate sustainable development on a human scale, and provide consumers with housing, health care, day care, elder services, electricity and even banking services (credit unions) as well as food. International Cooperative Principles guide co-ops to get these products and build connections with producers and vendors.
Thanks to those efforts we have a thriving organic and natural food industry. Food co-ops are changing the way Americans look at food and farming. | 2019-04-25T22:03:12Z | null | 264 | 794 | null | 0.501259 | [
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Our most sturdy indoor cabinet capable of dealing with all challenges an indoor environment can offer. Capable of dealing with dust and water to allow installation in any indoor environment.
With an industry leading IK10 (20 JOULE) rating, our cabinet guarantees the best possible protection for the defibrillator against vandalism. The impact resistance is very high thanks to its robust structure and due to the lack of hinges, the opening mechanism is rock solid and long lasting. The IK10 (20 JOULE) is the international standard for maximum protection against vandalism and our cabinet was successfully tested on this standard by DEKRA.
Our cabinet comes with a reassuring IP54 protection against intrusion and moisture. With rain and other forms of precipitation having no effect on the inside of the cabinet, the defibrillator remains operational at all time. The intrusion protection allows for installations near the shoreline and the materials used are resistant to salt spray.
DEKRA tested and passed the cabinet on IP54 and salt-spray protection.
The Solid Plus combines a rock solid construction with maximum user convenience. With no power socket required, the Solid Plus allows for installation in any indoor venue no matter the challenges this venue may bring.
100% recycled HDPE, 5,5 cm thick. | 2019-04-20T18:29:47Z | null | 797.6 | 1,310 | null | 0 | [] | [] | true | [] |
2. Touch Music. This will launch the music app menu, wherein you can see the Playlists, Tracks, Albums, Artists, etc.
a. Touch the Playlists button.
b. Touch the Menu icon at the upper-right corner or the screen. It's the one represented by three vertical dots.
c. Touch the select Create playlist from the sub-menu items.
d. Enter a name you like to assign to your playlist.
e. Touch the OK button to complete action.
a. Get to your Playlist. Since you just have it created, it's still empty or has no tracks.
b. To populate your playlist with your favorite music files, touch the Add (+) icon. You may copy or download music files directly to your playlist.
c. To transfer music files, go to Tracks and touch to select the audio files you want to be added into your playlist. Or you can touch the box next to Select All to select all music files at once.
d. Touch Done after selecting tracks to transfer/add. All selected files will now be transferred or added into your Playlist.
e. Press the Return key, when done.
a. Launch the Music application.
b. Once you're in the Music menu, touch your preferred category, like Playlists, Tracks, Albums, etc.
c. Go to the playlist or audio file you want to play.
d. Touch the audio file you want to listen to.
a. To go to the next music or audio file, touch the Arrow right.
b. To go back to the previous music or audio file, touch the Arrow left twice.
c. To fast forward or rewind the current audio file or music, touch the indicator bar (line) located at the bottom of the screen and then slide it right or left.
E. Turn Shuffle ON/OFF. The shuffle icon is located on top-left of the indicator bar. It's the one represented by two-arrows-going-right with slanting bar on it. Simply touch that icon to turn shuffle on or off.
F. Turn Repeat ON/OFF. The repeat icon is located on top-right of the indicator bar. It's the one represented by an right-arrow with a big letter A on it. Touch that icon repeatedly to select the required setting. You can let the music player repeat one or more audio files.
G. Adjust the sound volume. To turn the music volume high or low, press the upper or lower part of the Volume key on your phone.
Once you've set the sound to a desired volume, you may now go back to the Home screen by pressing the Home key and then enjoy listening to your favorite music tracks. | 2019-04-25T03:53:16Z | null | 631.1 | 2,343 | null | 0 | [] | [] | true | [] |
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