text
stringlengths 174
850
| embeddings_A
list |
|---|---|
Hematopoietic stem cells (HSCs) in adult marrow are believed to be derived from fetal liver precursors. To study cell kinetics involved in long-term hematopoiesis, we studied single-sorted candidate HSCs from fetal liver that were cultured in the presence of a mixture of stimulatory cytokines. After 8–10 d, the number of cells in primary cultures varied from 10,000 cells. Single cells in slow growing colonies were recloned upon reaching a 100–200 cell stage. Strikingly, the number of cells in subclones varied widely again. These results are indicative of
|
[
-0.0033725032,
0.002511403,
-0.0007101987,
-0.03429687,
-0.02406399,
-0.00856753,
-0.019917332,
0.012433284,
-0.045854006,
-0.010446901,
0.016707016,
0.0017305607,
-0.003822282,
0.00620661,
-0.030176966,
0.021629501,
0.026632242,
-0.013021843,
-0.0039025398,
0.0076780044,
-0.026123943,
-0.0030414395,
0.0059658363,
-0.002215452,
-0.008313379,
0.013831109,
0.013831109,
-0.013724099,
0.0035982286,
-0.024478655,
-0.0007791703,
-0.008527401,
-0.0027638809,
-0.007096135,
-0.009008948,
-0.009604194,
0.003228708,
-0.0120052425,
0.010239569,
0.019409033,
0.019181635,
0.022271564,
-0.008453831,
-0.0003701477,
0.013383003,
-0.0023926883,
-0.009711204,
-0.0009689468,
-0.009811527,
0.03448414,
0.034724914,
-0.0056782453,
-0.005404031,
0.024371644,
-0.03713265,
-0.008279938,
0.005738439,
0.01902112,
0.0046047964,
-0.011891544,
0.005741783,
-0.008647787,
-0.012045371,
0.015596783,
-0.010226193,
0.011162534,
-0.01045359,
0.0110689,
0.0014404618,
-0.00057225546,
0.020719912,
0.0005735095,
-0.0033908957,
-0.00910927,
0.017469468,
-0.012252704,
-0.020893803,
-0.004965957,
-0.0019679903,
-0.000030070581,
0.019141506,
-0.022646101,
-0.016707016,
0.031594854,
0.009604194,
0.013496702,
0.0049525807,
0.014085259,
0.01876697,
0.009938601,
0.028973097,
0.029534902,
0.019850451,
0.014031754,
0.00918284,
-0.0031534662,
0.0072767152,
0.032905735,
-0.009102582,
-0.044329107,
-0.030364234,
-0.0055478266,
-0.009972042,
-0.022044167,
-0.038791314,
0.019395657,
0.009029012,
-0.000980651,
0.014901214,
-0.00095640647,
-0.014071883,
0.02707366,
0.024264634,
-0.02870557,
0.017415961,
-0.0031250415,
0.0011570512,
0.024732806,
-0.01393812,
-0.0073502846,
0.029989697,
0.029748924,
0.0165465,
-0.020372126,
0.013021843,
0.014794203,
-0.018606454,
-0.010767933,
-0.010553912,
0.0027454887,
0.002297382,
-0.021201458,
-0.0029762299,
0.018098153,
-0.012567047,
-0.00021057246,
-0.009283163,
0.00348453,
-0.011202663,
-0.037186153,
-0.004424216,
0.012627241,
0.011336426,
0.0025247794,
-0.0144865485,
0.00509972,
0.022177929,
0.0021485705,
-0.0013643841,
-0.01165077,
0.012319585,
-0.010801374,
0.031273823,
0.0014948031,
0.00011662474,
0.0080993585,
0.0256959,
0.023756335,
-0.026618866,
-0.004601452,
0.010901696,
-0.023729581,
0.022886874,
-0.0036684542,
-0.0030665202,
0.019409033,
0.01934215,
0.008206369,
0.019128129,
-0.009209593,
-0.0061062877,
0.0021168017,
-0.013911367,
0.01012587,
-0.017255446,
0.0027137198,
0.0037119272,
-0.0009982075,
-0.025923297,
-0.035955533,
-0.017054802,
0.0123797795,
0.038122497,
0.007189769,
0.0016904317,
-0.008754798,
0.030872533,
-0.023368422,
0.0023207907,
0.005062935,
-0.010393396,
0.009918537,
-0.004601452,
-0.011115718,
-0.6446313,
-0.023823217,
-0.0035045943,
-0.01923514,
0.026030308,
0.020278493,
0.016198717,
-0.0046583014,
-0.035688005,
0.010440214,
0.008554153,
0.025869792,
-0.0007628679,
-0.0075910585,
-0.0071630166,
-0.0150617305,
-0.010326515,
-0.0044074957,
0.005450848,
-0.0064005665,
-0.020425633,
-0.009637634,
-0.018084778,
0.038202755,
-0.004210195,
0.008694604,
0.02830428,
-0.0019646462,
-0.019796945,
0.020452386,
0.006771759,
0.01466044,
-0.0033474227,
0.0025197633,
0.04719164,
0.009557377,
-0.014018377,
0.007885338,
0.00689549,
0.047378905,
-0.0015340961,
0.00071605085,
0.0100523,
-0.010988642,
-0.027822735,
-0.0029628538,
-0.010005483,
-0.0026903113,
-0.0073502846,
-0.010186063,
0.015436267,
-0.00036325055,
-0.011951737,
-0.008507336,
-0.010219504,
-0.00662462,
0.018231917,
0.00024160968,
0.00069515035,
-0.00062367064,
-0.0013217471,
0.017643359,
-0.02039888,
0.0048756665,
-0.001147855,
0.018285422,
-0.018191788,
-0.0130954115,
0.017215317,
-0.016252222,
0.017108306,
0.028010003,
-0.022124425,
-0.010754556,
0.0018409153,
0.005701654,
0.011443437,
-0.0038624108,
0.0022288284,
0.003193595,
0.0040229266,
-0.0036784864,
-0.007109511,
0.014847709,
0.013844485,
-0.018807098,
-0.027153919,
0.017589854,
-0.00740379,
0.021950532,
-0.0072031454,
0.019047871,
0.017884133,
-0.055698972,
-0.019984214,
0.030417738,
-0.010065677,
-0.002386,
0.011831351,
-0.03368156,
-0.013677281,
-0.00758437,
0.028919592,
0.006290212,
0.011423373,
0.004200163,
-0.050027415,
-0.007704757,
0.03287898,
-0.04355328,
0.018753594,
0.013122165,
-0.02431814,
-0.003444401,
-0.012259392,
-0.010119182,
-0.008213057,
0.011109029,
-0.0062433947,
-0.025789535,
0.027247552,
0.00092547375,
-0.0024144247,
0.0035045943,
0.010640858,
0.00638719,
0.0015859293,
-0.00662462,
0.0047385595,
-0.0026652308,
0.00044559847,
-0.006517609,
0.037373424,
-0.036758114,
0.04082451,
-0.015891062,
0.016947791,
-0.008306691,
0.020706534,
-0.026337963,
-0.046362307,
-0.0039493567,
-0.0019345495,
-0.029267376,
0.0038757871,
-0.0074171666,
-0.026632242,
-0.01128961,
0.00076412194,
-0.004598108,
-0.0043539903,
-0.004731871,
-0.03023047,
-0.00459142,
0.0100723645,
-0.010426837,
-0.004855602,
-0.027180672,
0.017696865,
-0.0111224055,
-0.023970356,
0.03600904,
0.012687434,
0.030096708,
-0.0005827057,
0.0032253638,
-0.022057543,
0.0026418222,
0.0044977856,
-0.01730895,
-0.0071161995,
-0.025013708,
-0.0013501717,
0.02050589,
-0.01531588,
-0.017482843,
-0.014406291,
0.011858103,
-0.013550207,
-0.0021117856,
-0.007958907,
-0.026164072,
-0.0004514506,
-0.015543277,
0.027501702,
0.028224023,
0.012827885,
0.0029411172,
-0.003865755,
0.033119753,
-0.0027872894,
0.012500166,
-0.020479137,
0.011443437,
0.02076004,
-0.030444492,
-0.016640136,
0.00042323495,
0.0019261893,
0.02082692,
0.029347634,
0.0022054198,
0.01480758,
-0.0046583014,
0.007484048,
-0.025348116,
-0.011115718,
-0.004467689,
-0.004287109,
0.0024094086,
0.0053705904,
0.0038624108,
-0.0038490344,
-0.008707981,
0.0038590666,
0.006591179,
-0.011817974,
-0.012841262,
0.0030263911,
0.00442756,
0.011958425,
-0.012801133,
0.02355569,
-0.013456573,
-0.013897991,
0.005072967,
0.001320075,
0.016278975,
0.0056715575,
-0.004384087,
0.00041382972,
0.004761968,
0.008085982,
-0.00086026423,
0.007791703,
0.022913627,
0.014673817,
-0.03517971,
0.02076004,
0.00450113,
0.0021903715,
0.0073034675,
0.0039493567,
0.004802097,
-0.0041566896,
-0.029374387,
0.028946344,
-0.01546302,
-0.008460519,
0.02166963,
-0.00827325,
0.015877685,
-0.012807821,
-0.0015173757,
-0.004638237,
0.008808303,
0.0039827977,
0.008734734,
0.004507818,
0.018405808,
0.013302744,
0.0030380955,
-0.016238846,
-0.03988817,
-0.009196216,
0.00834682,
0.010346579,
0.0036417015,
-0.02137535,
-0.007189769,
-0.036758114,
0.005658181,
0.022405326,
-0.0351262,
0.000041722607,
0.0034544333,
0.03523321,
0.0037754648,
0.01673377,
-0.0119718015,
-0.0153693855,
-0.0057183746,
0.00058437773,
0.030765524,
-0.02304739,
-0.012460037,
-0.020733288,
-0.030203719,
0.00086026423,
-0.0049960534,
0.00016908497,
-0.0100723645,
-0.0032236918,
-0.016038202,
-0.018539572,
-0.024719428,
0.021174707,
-0.00011672924,
0.025789535,
-0.007229898,
-0.011958425,
-0.022365198,
-0.034992438,
-0.021254964,
0.034510892,
0.008192993,
0.0049458924,
-0.016559877,
0.003782153,
-0.0080993585,
-0.017121682,
-0.026150694,
-0.0064039105,
0.026043685,
-0.00037349178,
-0.0035848522,
0.0072767152,
0.030605007,
0.029855933,
-0.020238364,
-0.0084070135,
-0.01629235,
-0.022311693,
-0.021081071,
0.025976803,
0.0057952884,
0.0004765312,
0.0009522264,
-0.004718495,
-0.031996146,
0.0015667009,
-0.0040630554,
0.027555209,
-0.0040730876,
0.0031367457,
-0.019208388,
-0.0048689786,
-0.010674299,
-0.014232399,
0.03194264,
-0.011784533,
-0.007918778,
-0.008701293,
-0.0040195826,
0.019288646,
0.007905402,
0.020024342,
0.04333926,
0.022565842,
0.0066814693,
0.004093152,
0.018272046,
-0.0032370682,
0.0056247404,
-0.010440214,
0.027100414,
-0.0049091075,
0.011911608,
0.017910885,
-0.024251258,
0.009724581,
-0.00025038788,
0.0065677706,
0.008935378,
0.013897991,
0.014326033,
0.005397343,
-0.011376555,
0.019074624,
-0.00560802,
0.010165999,
0.010881632,
0.011008707,
-0.03255795,
0.036062542,
-0.024197754,
-0.015248998,
-0.0011996882,
0.0076311873,
0.021509113,
-0.017335704,
-0.018927485,
-0.0012949945,
-0.0027521767,
0.003059832,
-0.03804224,
0.02990944,
0.009711204,
-0.01919501,
-0.020278493,
-0.0059691803,
-0.020492515,
-0.029454645,
-0.006009309,
0.008701293,
0.0037353358,
-0.021616124,
0.0035580997,
0.0038423464,
0.019730063,
0.029427892,
-0.0018960926,
-0.007062694,
0.021348597,
-0.02870557,
-0.02624433,
-0.011476878,
-0.017937638,
-0.016359232,
-0.0020114633,
0.0056782453,
-0.010246257,
-0.008052541,
-0.0060862233,
0.008728045,
-0.00008182543,
-0.035286717,
0.009042389,
-0.019944085,
-0.002504715,
0.026980026,
-0.018980991,
-0.026779382,
0.00023053242,
-0.020719912,
-0.03277197,
-0.022004038,
0.006199922,
-0.013289369,
-0.016158588,
-0.00314845,
-0.003999518,
-0.012299521,
-0.016559877,
0.019903956,
-0.026378091,
0.017081553,
0.008179616,
0.005012774,
0.005146537,
0.013336185,
0.0056347726,
0.016867533,
-0.014499925,
-0.0028809237,
0.0030247192,
0.02921387,
-0.007256651,
-0.027795982,
-0.013202422,
0.004939204,
-0.024344893,
-0.04103853,
0.0045813876,
-0.0069222427,
0.034243364,
-0.023997108,
-0.028331034,
-0.027956497,
0.0045278827,
0.017683487,
0.023676077,
0.013082036,
-0.022057543,
-0.008540777,
0.022525713,
-0.0030347514,
-0.01281451,
0.0073502846,
-0.02961516,
-0.008005724,
0.020880427,
0.0072432742,
-0.010547224,
-0.026645618,
-0.0017790499,
0.0038858193,
-0.000806759,
-0.015516525,
-0.018231917,
0.005865514,
-0.033093,
0.040342964,
0.015984695,
0.028331034,
0.01593119,
0.025388245,
0.001656991,
-0.0012197527,
0.004965957,
-0.0040563676,
0.012720875,
-0.005825385,
0.017763745,
-0.0017890821,
0.002681951,
0.008019101,
-0.021696381,
0.037640948,
0.05302371,
-0.009891785,
-0.015008225,
0.011771156,
-0.032531198,
-0.028357787,
0.011838038,
-0.002088377,
0.0070693824,
-0.010607418,
-0.015650287,
-0.003969421,
0.0025180911,
-0.0030314073,
-0.0009003932,
0.0366511,
-0.019917332,
-0.0021435544,
-0.01934215,
-0.0038423464,
-0.013202422,
0.0015466363,
-0.011249481,
-0.010333203,
0.009236345,
-0.007845208,
0.003745368,
0.02239195,
-0.032825477,
0.009657699,
-0.00048781748,
-0.036704607,
-0.025669148,
-0.02932088,
-0.02290025,
0.013924743,
0.0011177583,
-0.021147953,
-0.008654475,
-0.022151176,
0.014780828,
-0.010513783,
0.011644082,
0.0010057316,
-0.024304764,
0.04657633,
-0.015088483,
0.015449643,
-0.030176966,
0.033414032,
0.018165035,
-0.003028063,
-0.026766006,
-0.012567047,
-0.011082277,
0.00020210775,
0.032129906,
0.028785829,
-0.009457055,
-0.032210164,
0.01179791,
0.02493345,
-0.013663906,
-0.031701867,
0.010620793,
0.00867454,
-0.008487271,
-0.015182117,
0.00017754968,
-0.01995746,
0.009477119,
0.018967614,
0.009176152,
0.010968578,
0.005557859,
-0.015837556,
0.031568103,
-0.0011729356,
-0.0029845901,
-0.003155138,
-0.008788238,
-0.016519748,
-0.032397434,
-0.036597595,
-0.0029394452,
-0.016760522,
0.019850451,
-0.01734908,
0.009677763,
0.023609195,
-0.011664147,
-0.014138765,
-0.00907583,
-0.0074305427,
0.035072695,
-0.009771397,
0.004424216,
0.008748109,
0.036758114,
-0.009523936,
-0.01611846,
-0.01734908,
0.010025548,
-0.019128129,
-0.0057317507,
0.042937968,
0.021134578,
0.0025699243,
0.018272046,
-0.03143434,
-0.014366162,
-0.020345375,
-0.040771008,
0.013951496,
-0.03959389,
-0.0007352793,
0.013362939,
0.021335222,
-0.006634652,
-0.026538609,
-0.00885512,
0.01963643,
0.030551502,
0.0034711536,
0.036570843,
0.008447142,
0.016385986,
-0.029427892,
0.016760522,
-0.012747628,
-0.024893321,
0.00020795989,
-0.029989697,
-0.023943603,
0.0004769492,
0.007898713,
0.0086411,
-0.007865272,
0.00733022,
-0.004223571,
0.030845782,
0.024492031,
0.009089205,
-0.015262375,
0.01815166,
-0.023528937,
0.0002842467,
0.0006257607,
-0.013964872,
0.027194047,
0.00842039,
-0.008079294,
-0.0022438767,
-0.010085741,
-0.0065343296,
0.004594764,
0.0033106378,
-0.03103305,
0.00878155,
-0.035928782,
-0.012627241,
-0.0141120115,
-0.0062433947,
0.0068252645,
-0.020291869,
-0.013001777,
0.027194047,
0.009209593,
0.02533474,
-0.0072767152,
0.012807821,
-0.0055612028,
-0.023127647,
-0.019649806,
0.029187119,
-0.012841262,
0.04751267,
0.016051577,
0.005062935,
-0.04272395,
0.002593333,
-0.04863628,
-0.026618866,
0.033547796,
0.021335222,
0.007978972,
0.011369867,
0.0030431116,
0.0016394346,
-0.024144247,
0.017188564,
-0.028010003,
-0.007945531,
0.021321846,
0.009697828,
0.021870274,
-0.0033908957,
-0.014981472,
-0.0051197843,
0.023087518,
0.010741181,
0.0063504055,
0.021683006,
0.00067383185,
0.036249813,
-0.015730545,
0.019248517,
0.014901214,
0.000851486,
-0.012653993,
-0.01698792,
-0.0057150302,
0.005387311,
-0.01891411,
-0.009891785,
0.0026585425,
-0.0136705935,
0.0028658754,
-0.007450607,
-0.011102341,
-0.013964872,
0.031166812,
-0.017228693,
0.020184858,
-0.0017104963,
0.006290212,
0.019917332,
0.030738771,
0.002208764,
0.011483566,
-0.00035071024,
0.007256651,
-0.014647065,
-0.00878155,
0.0081327995,
0.005908987,
-0.0077983914,
-0.023823217,
-0.027140543,
-0.003531347,
0.0011394948,
-0.023207905,
-0.0262042,
0.043606784,
-0.010674299,
-0.014606935,
-0.008614346,
0.013657217,
-0.018058024,
-0.023943603,
0.006236707,
-0.010607418,
-0.017482843,
-0.0067383186,
-0.008580905,
0.008052541,
-0.008427078,
0.00042239894,
0.015663665,
0.0040262705,
0.013857862,
0.19079974,
-0.004477721,
0.0065610823,
0.024050614,
-0.0022605972,
-0.026324587,
0.012480102,
0.011985178,
-0.0011578873,
0.012513543,
0.022779863,
0.0031668425,
-0.003494562,
0.0017004639,
0.024652548,
-0.012373091,
-0.0021803393,
-0.011343115,
-0.009022324,
-0.021683006,
-0.008286627,
-0.012720875,
0.016533125,
-0.008835056,
0.021388726,
-0.007738198,
-0.012975025,
0.003996174,
0.014392914,
0.0040363027,
-0.0052167624,
0.011048836,
-0.015623535,
0.001443806,
0.009370108,
-0.014580183,
-0.007022565,
0.0036249813,
-0.0004982677,
0.0043172054,
-0.0022856777,
0.00827325,
-0.0017924261,
0.005524418,
-0.0055143856,
0.036089297,
0.0073502846,
-0.007524177,
-0.015021601,
-0.000056640332,
-0.038309764,
0.013677281,
0.008012412,
-0.008192993,
0.0075442414,
0.0016436146,
0.031220319,
0.025321363,
-0.0073034675,
0.026618866,
-0.011015395,
0.011690899,
-0.014780828,
0.0005835417,
0.005497665,
0.02584304,
-0.0006207446,
-0.016479619,
0.022004038,
-0.017228693,
0.0017589853,
0.0035413792,
-0.023167776,
-0.0035848522,
-0.0047385595,
-0.02376971,
0.022044167,
0.02025174,
0.015957944,
0.0149279665,
0.0012866342,
-0.012399844,
-0.03408285,
0.021455608,
0.0131021,
-0.01063417,
0.022873498,
0.022271564,
-0.038095742,
-0.017589854,
0.012874703,
-0.0026969993,
-0.0032571326,
-0.0071429517,
0.012767692,
-0.014058506,
0.015797427,
0.030551502,
-0.0021034256,
-0.035982285,
-0.016011449,
0.06484837,
0.030765524,
0.012326274,
-0.007858585,
0.019061249,
-0.011376555,
-0.0017589853,
-0.022819992,
0.002160275,
0.0114969425,
-0.028545056,
-0.0023759678,
-0.014968096,
-0.010145934,
0.021188082,
-0.01019944,
-0.03277197,
0.043259002,
-0.006434007,
-0.003313982,
-0.010038924,
0.02421113,
0.036784865,
-0.0084738955,
0.00067048776,
-0.033521045,
-0.0038155937,
-0.0115303835,
-0.022204682,
-0.0035146265,
0.0058554816,
0.0080993585,
0.026230954,
0.008560841,
-0.0059056426,
-0.0029829182,
0.0028558432,
-0.031407587,
-0.0059257075,
-0.0052869883,
-0.025642395,
0.024050614,
0.0100723645,
0.013777604,
-0.0027755853,
0.030551502,
0.016051577,
-0.03191589,
-0.016760522,
0.019221764,
-0.035019193,
-0.01252023,
-0.013777604,
0.017335704,
-0.013035218,
-0.022351822,
-0.004424216,
0.008246498,
-0.0037319916,
-0.010767933,
0.030471245,
-0.006591179,
-0.003441057,
-0.005865514,
-0.01429928,
-0.16864857,
0.00056765735,
0.029187119,
-0.007343597,
0.033815324,
0.011924984,
-0.004537915,
-0.002081689,
-0.01734908,
0.015596783,
0.040610492,
0.010426837,
-0.040342964,
-0.025281234,
0.006310276,
-0.0031534662,
-0.0052535473,
0.04965288,
0.026217576,
0.012734251,
0.028438045,
-0.0070560058,
0.026284458,
0.0075041126,
0.01444642,
-0.009029012,
0.017589854,
-0.00028361968,
-0.0063938783,
-0.024505408,
-0.017509596,
0.0016895958,
-0.00057267345,
-0.012239328,
-0.027060283,
-0.0086411,
0.00007518952,
-0.014847709,
0.02406399,
0.02504046,
0.023796463,
0.018445937,
0.00765794,
-0.0013092068,
0.00017692267,
0.04860953,
0.0065209535,
-0.009329979,
0.030899286,
-0.029641913,
0.0256959,
-0.008233122,
-0.0029712138,
0.01716181,
-0.0039794534,
0.017616605,
0.027234176,
0.0033106378,
0.015690416,
0.004477721,
-0.0022723014,
0.00036889367,
0.017362457,
-0.016519748,
-0.0020499201,
-0.022726359,
0.005350526,
0.02827753,
-0.014339409,
0.0067015337,
-0.024291387,
-0.008808303,
0.009958666,
-0.0059892447,
0.028919592,
0.0014513301,
-0.0033691593,
-0.0060026213,
0.0016519749,
0.021736512,
-0.028812582,
0.03523321,
-0.013189046,
-0.01821854,
-0.025575513,
0.011710963,
0.0123463385,
0.031193566,
-0.0048823548,
-0.017964391,
0.011731028,
-0.028464798,
-0.015556654,
-0.0028374507,
0.013884614,
0.020666406,
-0.024197754,
-0.02493345,
0.0014379538,
0.008353508,
0.037801463,
-0.01876697,
-0.030417738,
0.002039888,
0.04272395,
0.0021117856,
-0.029240623,
0.00987172,
0.05687609,
-0.005865514,
-0.0076646283,
0.0056715575,
0.010012171,
0.013490013,
0.0001273885,
0.036490586,
0.009156087,
-0.010393396,
0.007932154,
-0.04925159,
0.053157475,
0.0039292923,
-0.02711379,
0.03978116,
0.011082277,
0.0027856175,
-0.13579634,
-0.0016503028,
0.0024578979,
0.014861085,
0.007183081,
0.047566175,
-0.022592595,
0.007484048,
-0.005193354,
0.014794203,
-0.019061249,
-0.019903956,
0.005537794,
-0.016640136,
0.03132733,
0.0015884374,
0.011002019,
-0.0061096316,
-0.017175188,
0.02656536,
0.017255446,
-0.0074104783,
-0.03092604,
-0.0052836444,
0.002809026,
0.019796945,
-0.04250993,
0.027394691,
0.02196391,
0.042001627,
0.011403308,
-0.008253186,
0.011476878,
-0.01379098,
0.00086946046,
0.0022338445,
-0.02950815,
-0.020064471,
0.023181153,
-0.032397434,
-0.0024110808,
0.021428855,
-0.006982436,
-0.015289128,
0.011169222,
-0.010674299,
-0.017549725,
-0.0061129755,
0.016600007,
-0.025896545,
-0.037480433,
-0.024986956,
-0.02126834,
-0.01861983,
0.014499925,
-0.012446661,
0.020010967,
0.016452868,
-0.011811285,
-0.008112735,
0.0030681922,
-0.015008225,
-0.005390655,
0.008942067,
0.032611456,
-0.012045371,
-0.020425633,
-0.013182358,
0.018793723,
-0.037400175,
-0.022017414,
0.0016678593,
-0.028010003,
-0.0007515817,
0.0012849622,
-0.0017940982,
-0.0032069713,
0.002253909,
-0.01669364,
-0.016921038,
-0.007109511,
-0.019302022,
0.0055444823,
-0.015115235,
0.011296297,
0.010132559,
0.011697587,
-0.0078117675,
0.013831109,
-0.008353508,
-0.007109511,
0.030069955,
-0.007691381,
-0.02177664,
0.0034644655,
-0.005186666,
0.015917813,
0.007691381,
0.021455608,
0.021535866,
-0.026070436,
-0.007938842,
-0.0422424,
0.015021601,
0.015556654,
0.0042402917,
0.014285903,
-0.013369626,
0.008835056,
-0.020693159,
0.014205646,
0.01916826,
-0.009564064,
-0.001275766,
-0.024759559,
0.0032069713,
-0.030390987,
0.004547947,
0.0048689786,
-0.004150002,
0.008667852,
0.004808785,
0.00045228662,
-0.007932154,
0.0029712138,
0.003611605,
-0.00096476666,
-0.0046616457,
-0.004093152,
0.023809839,
0.0050529027,
-0.00052000425,
0.0039861416,
-0.050722983,
-0.017001295,
0.0031417618,
0.004892387,
-0.028625313,
0.018606454,
0.016559877,
0.030712018,
0.025495255,
-0.0071295756,
-0.0044977856,
0.011015395,
0.003989486,
-0.005022806,
0.019917332,
-0.0048856987,
0.007343597,
-0.0008978851,
0.008962131,
0.047271896,
-0.0014948031,
0.010346579,
-0.030658513,
-0.030043202,
-0.00014180984,
-0.014285903,
0.0030732083,
-0.012225951,
-0.02300726,
0.009416926,
0.010186063,
0.008768174,
0.008955442,
-0.0074171666,
-0.032183412,
-0.005016118,
0.0049826773,
0.009115959,
-0.007871961,
-0.03154135,
0.012446661,
0.0028391227,
0.007744886,
0.017469468,
-0.0145534305,
-0.0068687373,
0.010045612,
-0.0044476246,
0.0027354562,
0.013075347,
-0.016412739,
0.008794927,
0.012700811,
0.048395507,
0.017844003,
-0.0001191328,
0.052649174,
-0.012500166,
-0.0011879839,
0.0024746181,
-0.0057651917,
0.020599524,
-0.0058588255,
0.012172447,
0.029882686,
-0.010754556,
0.015730545,
0.0059390836,
0.0417341,
-0.0060226857,
0.006831953,
0.01342982,
-0.02838454,
-0.010767933,
0.009082518,
-0.0110555235,
-0.025401622,
-0.016773898,
-0.009390173,
0.0065844906,
0.01607833,
0.0046081403,
-0.00502615,
-0.022258187,
0.009838279,
-0.018245293,
-0.0033808635,
-0.0018459314,
0.028117012,
0.00733022,
0.022766488,
-0.0060260296,
-0.017255446,
0.002768897,
-0.0056782453,
0.02830428,
-0.013563583,
0.022057543,
0.007972283,
0.020933932,
-0.008219745,
-0.02257922,
-0.013215799,
-0.011804597,
-0.013951496,
0.03033748,
0.01048703,
-0.024130872,
0.059390835,
-0.0057986323,
-0.020666406,
-0.0024562257,
-0.012948273,
0.017496219,
0.0000020851505,
0.006637996,
-0.028224023,
-0.032076403,
0.0345644,
-0.027127165,
0.018887356,
-0.050910253,
-0.008460519,
0.011958425,
-0.003618293,
0.004768656,
0.005049559,
0.0019730064,
-0.0013451556,
-0.006688157,
0.009724581,
0.017255446,
-0.014219022,
0.00671491,
0.017763745,
-0.026538609,
0.015516525,
-0.02649848,
0.026257705,
-0.0008460519,
-0.039139096,
0.0067516947,
-0.0057250625,
0.025414998,
-0.024652548,
-0.028759075,
0.0035781641,
0.03488543,
-0.020198235,
0.013469948,
-0.016024824,
0.00620661,
-0.022351822,
-0.02870557,
-0.019917332,
-0.008487271,
0.0055879555
] |
Despite rapid progress in characterizing transcription factor-driven reprogramming of somatic cells to an induced pluripotent stem cell (iPSC) state, many mechanistic questions still remain. To gain insight into the earliest events in the reprogramming process, we systematically analyzed the transcriptional and epigenetic changes that occur during early factor induction after discrete numbers of divisions. We observed rapid, genome-wide changes in the euchromatic histone modification, H3K4me2, at more than a thousand loci including large subsets of pluripotency-related or developmentally regulated gene promoters and enhancers. In contrast, patterns of the re
|
[
-0.013471061,
-0.0020566257,
0.0069513293,
-0.02546423,
-0.01288252,
0.0003459725,
-0.024444092,
0.012634025,
-0.023384716,
-0.014334256,
0.0077556693,
0.010345252,
-0.008442301,
-0.0016536382,
-0.007199825,
0.007036341,
0.027857631,
-0.016439926,
-0.015393631,
0.027936105,
-0.040073138,
-0.001348741,
0.009612845,
-0.008422683,
-0.017538538,
0.009684778,
0.0068793963,
-0.03151967,
-0.0100444425,
-0.013471061,
-0.006457608,
0.004780265,
-0.0039693858,
0.0071409703,
-0.030185642,
-0.011103816,
-0.015014349,
-0.031258095,
0.004034779,
-0.0122678215,
0.017787034,
0.029400919,
-0.016570713,
-0.002084418,
0.006774767,
-0.0056696166,
0.0070559587,
-0.0054603573,
0.008533852,
0.045566194,
0.015655205,
-0.001629933,
0.010188308,
0.012908678,
-0.027360642,
-0.018087843,
0.011836224,
0.025686568,
0.013327196,
-0.0029639604,
-0.002355801,
-0.0066374405,
-0.010789928,
0.015668284,
-0.0060848654,
0.02063819,
-0.023960179,
0.00045489357,
0.0007389466,
-0.00623854,
0.03743124,
0.014556594,
-0.015419788,
-0.013353353,
0.017460065,
-0.0060881353,
-0.003573755,
-0.0070494195,
-0.0069513293,
0.019448027,
0.003290928,
-0.013098319,
-0.009063539,
0.027622215,
-0.007095195,
0.0051758955,
0.008363829,
0.019539578,
0.015184372,
0.008219963,
0.022678467,
0.034553926,
0.041119434,
0.018140158,
-0.009880958,
-0.013798029,
0.007840681,
0.025634253,
0.009593227,
-0.02304467,
-0.027700689,
0.01802245,
0.010574129,
-0.014281941,
-0.04598471,
0.010646062,
0.02406481,
0.0014729886,
-0.00016021408,
0.0012481984,
-0.007690276,
0.009521294,
-0.014072682,
-0.043395128,
0.039602306,
-0.020899763,
0.008442301,
0.0041296,
-0.023777077,
-0.016793052,
0.024574878,
0.021867588,
0.0006404476,
-0.046324756,
0.007304454,
0.01609988,
-0.02304467,
0.02596122,
-0.0049666367,
-0.015406709,
0.023332402,
-0.02887777,
0.0143734915,
0.017564695,
-0.03131041,
0.00009369663,
-0.001081445,
-0.0027105608,
-0.016021408,
-0.0402824,
0.00042137937,
0.010757231,
-0.0046985233,
-0.010077138,
0.0017639897,
0.0015040506,
0.007690276,
0.0021105753,
0.02777916,
0.0006392215,
0.011555032,
-0.0011231335,
0.033743046,
0.008520774,
-0.0070101833,
0.025804276,
0.03029027,
0.011927775,
-0.016073722,
-0.002275694,
0.006369327,
-0.007520253,
0.004741029,
0.030054854,
0.0017623549,
0.03128425,
0.010404106,
0.010410646,
0.009331653,
-0.01579907,
-0.0318074,
0.0012964262,
-0.0535442,
0.00092858775,
-0.00352144,
0.0038974527,
0.00744832,
0.00443041,
-0.04104096,
-0.018990273,
-0.00054644444,
0.02092592,
0.03293217,
0.018375574,
-0.009279338,
-0.009070079,
0.00583964,
-0.018493282,
-0.0025552511,
-0.01763009,
-0.0002521737,
0.010920715,
-0.011914697,
0.0023803236,
-0.6407517,
-0.017460065,
0.023070827,
-0.023593975,
0.026039694,
0.02133136,
0.004132869,
0.0023721494,
-0.011299998,
0.024705665,
-0.0014394745,
0.011522335,
0.020376615,
-0.020677425,
-0.021972217,
-0.035077076,
-0.008331132,
-0.016152196,
0.016623028,
0.015210529,
-0.01882025,
-0.0011402993,
-0.0086123245,
0.028773142,
0.012457462,
0.014478122,
0.023868628,
-0.0019013161,
-0.020860527,
0.037012722,
-0.014569673,
0.0051464685,
-0.016963074,
-0.0101032965,
0.051687025,
0.0067486097,
0.00048513804,
0.024601037,
0.034161568,
0.04860045,
-0.00714751,
-0.008089176,
0.014451964,
0.031205779,
-0.01659687,
0.020494323,
-0.011430784,
0.01479201,
0.011522335,
-0.0019797883,
0.0127648115,
0.0054080426,
-0.017054625,
0.006048899,
0.02817152,
0.015275923,
0.009482058,
-0.0054472787,
0.013242184,
-0.006179686,
-0.0028053813,
0.011404627,
-0.034083094,
-0.0064151026,
-0.012065101,
0.00694479,
0.0017836078,
-0.009416664,
0.0013520106,
-0.0156028895,
0.000774913,
0.01862407,
0.0031634108,
0.0020795134,
0.00956707,
0.018074764,
0.0075660283,
-0.0017819729,
0.01026024,
0.02133136,
-0.0096063055,
-0.0038385987,
-0.019539578,
0.0037405083,
0.007873378,
-0.009684778,
-0.011077659,
0.020206593,
-0.01832326,
0.0014746235,
0.0018048607,
-0.003894183,
0.005744819,
-0.03774513,
-0.041930314,
0.008690797,
-0.008233042,
0.007860299,
-0.013614927,
-0.014948955,
-0.0032991022,
-0.0063791364,
0.010809546,
0.025019554,
0.038634483,
0.015171292,
-0.029348604,
-0.009416664,
0.036489576,
-0.013392589,
-0.0051268507,
-0.0004606155,
-0.021174416,
-0.011352312,
-0.016243747,
-0.019330319,
0.009652081,
0.007585646,
-0.0024587957,
-0.011940854,
0.01781319,
-0.011326155,
-0.013798029,
0.019291084,
0.01318333,
0.022495365,
-0.010901097,
-0.007866838,
0.0017018659,
0.0020419122,
0.01208472,
-0.024365619,
0.017656246,
-0.028720826,
0.016714578,
-0.01207164,
0.033272214,
-0.009148551,
0.015589811,
-0.017133098,
-0.031676613,
0.0015833402,
0.007860299,
-0.007840681,
-0.010593748,
-0.024378698,
-0.0138765015,
-0.0015808879,
0.01740775,
0.0009318574,
0.012993689,
0.0036881936,
-0.0055322903,
0.0020582606,
0.018166315,
-0.012692879,
-0.008703875,
-0.031153465,
0.009246641,
-0.030159483,
-0.017473144,
0.034684714,
-0.011084199,
0.017041547,
0.0003568033,
-0.024993397,
-0.017904742,
0.015053584,
-0.01993194,
-0.01832326,
0.00062123826,
-0.01156811,
-0.02123981,
0.0071867458,
-0.007729512,
0.0068990146,
-0.00814803,
0.000086442036,
-0.0024032113,
-0.005192244,
-0.015655205,
-0.01942187,
-0.014635066,
-0.020363538,
0.034684714,
0.005074536,
0.01802245,
0.010907636,
0.0054211216,
0.02696828,
-0.008017244,
0.0010798102,
0.0029835785,
0.016112959,
0.015040506,
-0.0125293955,
0.0056369198,
-0.00047819,
-0.009063539,
0.022783097,
0.017368514,
0.0023492617,
-0.0020190245,
-0.03384768,
0.004355207,
-0.03350763,
0.011025345,
-0.03149351,
-0.019173374,
0.014935876,
0.00068499695,
-0.0021089404,
-0.013575691,
-0.018035527,
-0.0024179248,
0.008357289,
-0.019500343,
-0.0032075513,
-0.006388945,
-0.0024587957,
0.00513666,
-0.0040282398,
0.027203698,
0.0077425907,
-0.015707519,
0.0072521395,
0.0012171366,
0.008370369,
0.014517358,
-0.001971614,
0.0059835054,
0.013248724,
-0.0007050237,
0.0018931419,
0.02848541,
0.021802194,
0.020782055,
-0.012208967,
0.0388699,
0.003694733,
0.0023198344,
0.012954453,
0.011581189,
-0.0064968443,
-0.025411915,
0.0030064662,
0.05252406,
-0.007396005,
-0.015445946,
0.014661224,
-0.02295312,
0.01609988,
-0.004217881,
-0.0034168104,
0.010907636,
-0.03512939,
-0.0015302079,
0.012137034,
0.016021408,
0.025542703,
-0.008821583,
-0.02143599,
-0.012614407,
-0.028511567,
-0.0015277558,
0.0021465418,
0.008985068,
-0.0018490013,
-0.01922569,
-0.0000062551694,
-0.013032925,
0.019003352,
0.01358877,
-0.01500127,
0.00028446174,
-0.007958389,
0.01237899,
0.017080784,
0.0012964262,
-0.008206884,
0.0078014447,
-0.014621987,
0.024692588,
0.036097214,
-0.0006878579,
0.0006175599,
-0.019382635,
-0.028223835,
-0.0073109935,
0.012555553,
0.010776849,
0.004348668,
0.0021514462,
0.007173667,
-0.008998146,
-0.019081824,
0.027203698,
-0.012549013,
0.023214694,
-0.018179394,
-0.0011517431,
-0.0123266755,
-0.0273868,
0.0006711008,
0.0388699,
0.015563654,
0.0000974261,
-0.020729741,
-0.015720598,
-0.028328465,
-0.008239581,
-0.010999187,
-0.0071278918,
0.0046135117,
-0.017120019,
0.00613718,
0.0111561315,
0.011528875,
0.024679508,
0.010240623,
-0.012359372,
-0.01621759,
-0.0052151317,
0.017499302,
0.026994439,
0.03573101,
-0.010410646,
0.012156652,
-0.010090218,
0.0037372387,
-0.00048432063,
-0.024339462,
0.026837494,
-0.026811337,
0.011895078,
0.022429971,
0.01981423,
-0.00844884,
0.00073281594,
0.020180436,
0.00130787,
-0.038189806,
-0.021265967,
-0.005784055,
-0.0008828123,
0.009318574,
0.030839575,
0.03492013,
0.011927775,
-0.013562612,
0.015236686,
0.02657592,
-0.008841202,
-0.010449882,
-0.022011453,
0.01751238,
0.004914322,
0.010018284,
0.011129974,
-0.026105087,
0.025712725,
0.00825266,
-0.00664398,
0.027334483,
0.007258679,
0.024182517,
0.019618051,
-0.011581189,
0.0068009244,
-0.0010904367,
0.0067486097,
-0.0010446612,
-0.0056728865,
-0.032042816,
-0.013346814,
-0.026183559,
-0.025908906,
-0.0003612991,
0.013771872,
0.001711675,
0.014608908,
-0.035600223,
0.007304454,
-0.01066568,
-0.013981131,
-0.029217817,
0.013000228,
-0.006189495,
-0.012934835,
-0.014177311,
0.012137034,
-0.011496178,
-0.011816606,
0.010050981,
0.010109835,
-0.042819664,
-0.04781573,
0.01348414,
0.025019554,
0.031258095,
0.0026402627,
-0.02053356,
-0.004034779,
0.019958097,
-0.004008622,
-0.028354622,
0.0097240135,
-0.020049648,
0.020598954,
0.0003004014,
0.0029508818,
-0.019068746,
0.007722973,
0.012719036,
0.017499302,
-0.014948955,
0.021122102,
0.0035149008,
-0.0059573483,
0.02265231,
0.025346521,
0.018964116,
0.00050802575,
-0.011352312,
-0.009416664,
-0.03858217,
-0.006624362,
-0.012202428,
-0.0048260405,
-0.009063539,
0.0015015983,
-0.0074417805,
-0.027229855,
-0.0187287,
0.022626152,
-0.016034488,
0.018597912,
0.016282983,
0.03544328,
0.017185412,
0.00044998905,
0.018584834,
-0.004263656,
-0.0037372387,
0.0029312638,
-0.015746756,
0.043813646,
0.010227544,
-0.015982172,
0.009076619,
0.0054080426,
-0.011044962,
-0.01982731,
-0.0019356477,
-0.009508215,
0.046010867,
-0.0064968443,
-0.016060645,
-0.005483245,
-0.0062156525,
0.010619905,
0.021488305,
0.0217368,
-0.014700459,
-0.013497219,
-0.004577545,
-0.013719557,
-0.011293458,
0.013131015,
-0.038686797,
0.0017737987,
0.023803236,
0.016766895,
0.009037382,
0.0066407104,
-0.00036599927,
-0.018794093,
-0.030944206,
-0.01581215,
-0.027099067,
0.009900576,
-0.03301064,
0.04862661,
0.022900805,
0.0489405,
0.02526805,
0.0005697409,
0.022979276,
0.002777589,
0.0052903346,
-0.0047148718,
0.018924879,
-0.017891662,
0.013131015,
0.0050516482,
-0.003946498,
0.0091093145,
-0.03251365,
0.027936105,
0.023737842,
-0.017564695,
-0.020768976,
0.017120019,
-0.040622443,
-0.031441197,
0.0039301496,
0.005748089,
0.0041132513,
-0.027857631,
0.016387612,
-0.0016642646,
-0.0035966428,
0.01056759,
0.017538538,
0.03371689,
0.0015522783,
0.023934022,
-0.00091223937,
0.00075938203,
-0.021109022,
0.0014827977,
-0.012097798,
-0.0041296,
0.018964116,
0.0008623768,
0.029845595,
0.007834142,
0.0019454567,
-0.0065753167,
0.033743046,
-0.026445132,
-0.031362724,
-0.0147527745,
-0.014857404,
-0.012169731,
-0.0058952244,
0.0074940952,
-0.031388883,
-0.015053584,
-0.003181394,
-0.023423953,
0.01630914,
-0.02193298,
-0.010391028,
0.020703582,
0.0054342,
0.0053491886,
-0.013771872,
0.008246121,
0.01912106,
0.0067682276,
-0.030787261,
-0.03191203,
-0.025895827,
0.000033437536,
0.040622443,
0.005999854,
-0.0035116312,
-0.0173162,
0.0112738395,
-0.010090218,
-0.046220127,
-0.032539807,
-0.005071266,
-0.008481537,
-0.02696828,
0.0031225397,
0.011201907,
-0.020337379,
0.0058657974,
0.0012964262,
0.021802194,
0.003501822,
-0.0046952534,
-0.032147445,
0.02979328,
-0.01408576,
0.0028805838,
0.009187787,
-0.013758793,
0.0056303805,
-0.019448027,
-0.012804048,
0.014700459,
-0.019539578,
0.019382635,
-0.024339462,
0.0011051502,
0.010894557,
0.0076968153,
-0.01338605,
-0.009841722,
0.0039563067,
0.040674757,
-0.011110356,
-0.00068254466,
0.007860299,
0.0061960346,
0.0071540494,
-0.008095715,
-0.002131828,
-0.0028609657,
-0.021749878,
0.0021759688,
0.024404855,
0.018153237,
0.015929857,
-0.0065687774,
-0.021815272,
0.008102255,
-0.027256012,
-0.0388699,
0.016230667,
-0.03735277,
0.008775808,
0.017826268,
0.045540035,
0.025241893,
0.0064052935,
0.021919902,
0.0053295703,
0.027596058,
-0.025542703,
0.02273078,
0.016936917,
-0.005911573,
-0.024692588,
0.021985296,
-0.02887777,
-0.025778119,
0.008560009,
-0.01901643,
-0.031362724,
0.0108684,
0.010194847,
0.02406481,
0.00765104,
0.0051072324,
-0.012418226,
0.019604972,
0.0066962945,
-0.010731074,
-0.024313305,
-0.010999187,
-0.020455088,
0.005293604,
0.024117123,
-0.010345252,
-0.0028724095,
-0.011940854,
-0.011967011,
0.015132057,
-0.025137262,
-0.0062548886,
0.016531477,
-0.0022266489,
-0.021174416,
0.013248724,
0.0071540494,
-0.008501155,
-0.014922798,
0.0109795695,
0.0019585355,
-0.013680321,
-0.028694669,
0.01609988,
0.013523377,
-0.0073109935,
-0.002324739,
0.0067486097,
-0.008376908,
-0.031258095,
-0.044415265,
0.0149881905,
-0.02263923,
0.022560759,
0.03442314,
-0.017957056,
-0.026759021,
-0.0004483542,
-0.050300684,
-0.024810296,
0.006964408,
0.0063529788,
0.014281941,
0.009658621,
-0.010489118,
-0.0136934,
-0.017695481,
0.0042015323,
0.010946873,
-0.016112959,
0.0059835054,
0.0014149519,
0.013497219,
-0.00583964,
-0.03633263,
-0.016636107,
0.013863423,
-0.0094885975,
-0.0064968443,
0.012954453,
-0.01621759,
0.038372908,
-0.016282983,
0.019801153,
0.020782055,
0.023293165,
0.031258095,
-0.01763009,
-0.015563654,
0.008076098,
-0.0009580148,
-0.039706934,
0.0022380927,
-0.004420601,
0.0024473518,
-0.008219963,
-0.018100921,
-0.026732864,
0.004247308,
-0.028720826,
0.027517585,
0.0018097652,
-0.0022053958,
0.001983058,
0.004136139,
-0.007925693,
-0.014451964,
0.0042800047,
-0.017970135,
-0.002457161,
0.008278818,
-0.018480204,
-0.00085992453,
0.010024824,
-0.012490159,
-0.0071278918,
-0.009148551,
-0.010083678,
-0.024888767,
-0.029767122,
0.013098319,
-0.006693025,
-0.012058562,
-0.0035704852,
-0.008592706,
-0.008474998,
-0.018676385,
-0.0096063055,
-0.0040576668,
-0.0040903636,
0.005653268,
-0.024784138,
-0.0039497674,
0.002445717,
0.00533284,
0.005094154,
-0.014072682,
0.017695481,
0.18048607,
-0.015014349,
-0.005597684,
0.0040413183,
0.0049535576,
-0.022129161,
0.02384247,
-0.00084521103,
-0.019068746,
-0.013784951,
0.024836453,
0.012444383,
-0.004881625,
-0.009508215,
0.019565737,
-0.008272278,
-0.012143574,
0.01328796,
-0.02717754,
0.004914322,
0.025189577,
-0.01781319,
0.008017244,
-0.0009367619,
0.01721157,
-0.00216289,
-0.020075805,
0.026536683,
0.021776037,
0.012182809,
-0.03944536,
0.021200573,
-0.0018179393,
0.00044181486,
-0.005705583,
-0.0002648437,
0.008913134,
-0.018937958,
0.0013160442,
-0.015118978,
0.014778932,
0.0066014742,
-0.004812962,
-0.008906595,
0.0047933436,
0.008762729,
-0.0050974237,
-0.0005023038,
0.0035508673,
-0.0077687483,
-0.02728217,
0.0013528281,
0.005195514,
0.017224649,
0.009089697,
-0.015655205,
0.008226503,
0.020991314,
-0.00825266,
0.011908157,
-0.015419788,
0.009697856,
-0.043055084,
0.004770456,
-0.015589811,
0.014935876,
-0.007657579,
-0.0029966573,
0.022704624,
-0.024836453,
0.011463481,
0.01258171,
-0.03133657,
0.0026108357,
-0.016034488,
-0.025791198,
0.06429489,
0.008134952,
0.030525686,
0.015563654,
0.028903928,
0.004548118,
-0.03353379,
0.00029999268,
0.0034756646,
-0.031441197,
0.053282626,
0.011391548,
-0.042610407,
-0.0032484222,
0.017564695,
-0.0096063055,
-0.019644208,
-0.011705437,
-0.010888019,
-0.005427661,
-0.010456421,
0.022063768,
0.0059933146,
-0.01258171,
-0.03029027,
0.052968737,
0.007807984,
0.008690797,
-0.009580148,
0.017747797,
0.016374534,
0.0074744774,
0.005947539,
-0.011260761,
0.01479201,
-0.000363547,
0.019709602,
-0.0022184746,
0.002035373,
0.012725576,
-0.018794093,
-0.029740965,
0.05116388,
0.009312035,
-0.00844884,
-0.021069787,
0.0053786156,
0.01630914,
-0.017185412,
-0.0026418974,
-0.0100706,
0.015877543,
-0.027909948,
-0.015576732,
0.010920715,
-0.006722452,
0.011502717,
0.011698898,
-0.00043445808,
-0.02154062,
0.004760647,
-0.0057644374,
-0.015733676,
0.015289001,
-0.011110356,
-0.00603582,
0.0029279941,
-0.0075137136,
-0.008291896,
-0.01317679,
0.019356476,
0.022783097,
-0.010443343,
-0.013307578,
-0.0021220192,
0.0017574504,
-0.0065687774,
0.0028462522,
0.018467125,
-0.0067093736,
-0.010417185,
-0.028746983,
-0.017106941,
0.021056708,
-0.032958325,
0.050666887,
-0.0024718745,
-0.006493575,
-0.00266642,
-0.016662264,
-0.16332681,
-0.009207405,
0.027622215,
-0.024326382,
0.03544328,
0.030107168,
0.017983213,
-0.012804048,
-0.012320136,
0.011849303,
0.022861568,
0.0027710497,
-0.03400462,
-0.032644436,
0.011437324,
0.018872565,
-0.012110877,
0.04457221,
0.0064445296,
-0.0006923537,
0.008239581,
-0.017800111,
0.027569901,
0.0062875855,
0.00013180877,
-0.0057611675,
0.022416893,
-0.005427661,
-0.015328237,
-0.031388883,
-0.018074764,
0.0073109935,
0.018192472,
-0.010829164,
0.007592186,
-0.008769269,
0.003019545,
-0.0051464685,
-0.009037382,
0.028433096,
0.02265231,
0.005999854,
-0.01258171,
0.0030228146,
-0.005267447,
0.023123143,
-0.017185412,
0.0025928523,
0.010554511,
0.024823373,
-0.007840681,
-0.008893517,
-0.014308099,
0.008893517,
0.023881707,
-0.0070494195,
0.012562091,
0.011993169,
-0.020180436,
-0.01248362,
-0.023698606,
0.002022294,
0.05270716,
0.013059082,
0.006395485,
-0.021017471,
0.010731074,
0.009253181,
-0.03724814,
0.008520774,
-0.0024391776,
-0.0110972775,
-0.0076118037,
-0.021213653,
0.02083437,
-0.00041381826,
-0.0054015033,
0.00016235981,
0.003894183,
-0.012738654,
-0.029348604,
0.031022677,
-0.027700689,
-0.023293165,
-0.015746756,
-0.00044140616,
0.0063660573,
0.021514462,
-0.011842763,
-0.013372972,
0.027648373,
-0.019801153,
-0.008442301,
-0.004159027,
0.01901643,
0.012300518,
-0.007978007,
-0.019500343,
-0.0062156525,
-0.0147527745,
0.022979276,
-0.0015187641,
-0.010122914,
0.013444904,
0.06382406,
-0.009122394,
-0.025882749,
0.007075577,
0.053177997,
-0.0071932855,
-0.009920195,
0.0040217005,
0.0025323634,
0.010606826,
-0.01730312,
0.048365034,
-0.005777516,
0.009880958,
-0.014098839,
0.00068949274,
0.07486248,
0.007821063,
-0.00624181,
0.018362496,
-0.009684778,
-0.020716662,
-0.14072682,
-0.007526792,
0.0037078117,
0.007853759,
0.016126039,
0.031127308,
-0.005493054,
0.010691837,
0.0028135555,
0.019251848,
-0.021475226,
-0.023162378,
0.020245828,
-0.012398608,
0.010083678,
0.0008231407,
0.017499302,
-0.014844325,
-0.015929857,
0.048051145,
-0.0046004327,
0.0041524875,
-0.00029161415,
-0.023829393,
0.009246641,
0.026915966,
-0.039209943,
0.013510298,
0.02265231,
0.022482287,
-0.0139942095,
-0.022220712,
0.0047377595,
0.004548118,
-0.0067878454,
-0.013163712,
0.008422683,
-0.027936105,
0.027439114,
-0.010789928,
0.0024408125,
-0.018506361,
-0.0063824058,
0.009697856,
0.0028707748,
0.002668055,
-0.013222566,
-0.0037372387,
0.004145948,
-0.012614407,
-0.045827765,
-0.021396754,
-0.012908678,
-0.0112738395,
0.008906595,
-0.024287147,
0.023777077,
0.0108684,
-0.017577773,
0.0094297435,
-0.008278818,
-0.023227772,
-0.015210529,
-0.014844325,
0.010888019,
-0.01781319,
-0.029217817,
-0.017826268,
0.022835411,
-0.014438885,
-0.014124997,
0.008023783,
-0.022992356,
0.023162378,
-0.0388699,
0.0008219146,
-0.027125224,
-0.020768976,
0.009449361,
-0.030865733,
-0.0019552656,
-0.019291084,
0.01026678,
-0.0014419267,
0.03714351,
0.021906823,
0.0045710057,
-0.021449069,
-0.0007916701,
0.0025814085,
-0.019657288,
0.032487493,
-0.0016430118,
-0.021658327,
-0.015328237,
0.006058708,
-0.0057709767,
-0.0048848945,
-0.0029754045,
0.015472103,
-0.010384488,
0.0017656246,
-0.053387254,
-0.004969906,
-0.013928816,
-0.019879624,
0.0086581,
-0.0068074637,
0.00664398,
0.011313076,
-0.0014901544,
0.0032140906,
-0.013968052,
0.011496178,
-0.03965462,
-0.006686486,
-0.03243518,
-0.0039922735,
0.02525497,
-0.0033285292,
0.0075071743,
0.017067704,
-0.0034135408,
-0.0016487337,
0.018375574,
0.009043922,
-0.013641085,
0.0041099815,
-0.012934835,
0.020991314,
-0.0201412,
-0.014648145,
0.0060554384,
-0.031153465,
-0.019461107,
0.0027252743,
-0.003150332,
-0.013837265,
-0.0044958033,
0.039994664,
0.020455088,
0.04969906,
-0.0028511568,
-0.024914924,
0.0023427221,
0.00916163,
-0.00035741637,
0.01700231,
-0.028773142,
0.008867359,
0.0049372097,
-0.0122678215,
0.043368973,
0.012110877,
0.0076248823,
0.0010070599,
-0.0089916065,
-0.015459024,
-0.00814803,
-0.0060325507,
0.017329277,
-0.026458211,
0.020585874,
0.012339754,
0.02193298,
-0.0023345482,
-0.0031078262,
-0.013457983,
-0.023607055,
-0.0028119206,
0.004891434,
-0.022495365,
-0.018532518,
0.014569673,
0.01982731,
0.013745714,
-0.009410125,
0.00030367108,
-0.018087843,
0.0014917892,
-0.016557636,
0.018872565,
0.004911052,
-0.007722973,
-0.008167649,
0.0032664055,
0.042924296,
0.0031356185,
-0.014177311,
0.015642125,
-0.008429223,
0.009926734,
-0.004688714,
0.0016242111,
0.018859487,
0.01278443,
0.014805089,
0.0101621505,
-0.00372416,
0.01761701,
0.01942187,
0.023620132,
0.0072848364,
0.009096236,
0.022168398,
-0.01840173,
-0.018558675,
0.016400691,
-0.016727658,
-0.040988646,
-0.0141380755,
0.0067355307,
-0.0006224644,
-0.00286914,
-0.012261282,
-0.0030783992,
-0.017146176,
0.001750911,
-0.009691318,
-0.021095945,
-0.008900056,
0.04831272,
0.006833621,
0.008736572,
0.0013070527,
0.0024996665,
0.016989231,
-0.00835075,
0.017460065,
0.005453818,
0.016832288,
0.005385155,
0.025843512,
0.023515504,
-0.00916163,
-0.017865505,
-0.01358877,
-0.009135473,
-0.0005877241,
0.028328465,
-0.008187267,
0.08454072,
0.020101963,
-0.030891892,
0.010018284,
-0.008965449,
0.023227772,
0.014962033,
0.012804048,
-0.026510525,
-0.0015629047,
0.026863651,
-0.043552075,
0.009266259,
-0.03070879,
-0.014674302,
0.027229855,
-0.004064206,
0.025738882,
-0.01107112,
-0.0068924753,
-0.0047017927,
-0.016675344,
0.013628006,
0.018650226,
-0.052314803,
-0.011810066,
0.022534601,
-0.0051464685,
0.003763396,
0.005927921,
-0.0005566622,
-0.0061764163,
-0.03594027,
0.0037306994,
0.0012539204,
0.005627111,
-0.00432578,
-0.01910798,
0.04237499,
0.0095474515,
-0.0007356769,
-0.009952891,
-0.012895599,
-0.012771351,
-0.00523148,
0.012091259,
-0.0033743049,
-0.012934835,
-0.0033203552
] |
The relationship of migraine and stroke is complex. Stroke may be coincidental with migraine but migraine may confer an increased risk of stroke in women under 45 years of age and possibly in men who have migraine with aura. Stroke may mimic migraine but migraine syndromes may be symptomatic of underlying cerebrovascular disorders. True migraine-induced stroke is rare. The mechanisms of stroke induced during a migraine attack remain to be determined but probably involve an interaction between the dynamic shifts in cerebral blood flow and stroke risk factors.
|
[
-0.008746608,
-0.014260774,
0.016808698,
-0.016048124,
-0.035138547,
-0.0039391425,
0.008848018,
-0.011738201,
0.0012256342,
-0.0150847295,
0.0022151736,
0.027101807,
0.0021280244,
0.016986165,
-0.0031294476,
0.008182515,
0.055521946,
-0.009431125,
0.025986299,
-0.04416403,
0.001574231,
0.021790462,
-0.007041653,
0.004687041,
-0.0031690607,
0.01849464,
-0.009646621,
-0.023349639,
-0.009659297,
-0.011433971,
0.019952407,
-0.005114864,
0.010014232,
-0.010001556,
-0.014995996,
0.0036792795,
0.014539651,
0.0041863294,
-0.023451049,
-0.0044430234,
-0.005621914,
0.0063096,
-0.010267757,
0.00062549335,
-0.029028596,
0.009418448,
-0.0032308574,
-0.021093268,
-0.025707422,
0.049513407,
0.029256769,
-0.010533958,
-0.026975045,
0.02081439,
0.005073666,
-0.02355246,
-0.006572632,
0.005514166,
0.021232707,
-0.031944133,
-0.011472,
0.009760708,
0.0020662276,
-0.019052394,
-0.017227015,
-0.0072127823,
0.0144762695,
-0.0017509061,
0.013398789,
0.00874027,
0.052581057,
0.031766664,
0.024655294,
-0.0045571094,
0.026214471,
-0.036279406,
0.0006706525,
-0.034428675,
-0.0026873637,
-0.003444769,
0.0101093035,
-0.022272158,
0.0060307225,
0.017062223,
-0.007041653,
-0.009456477,
-0.0028790918,
0.003286316,
-0.014362183,
0.011351576,
-0.012631876,
0.013728371,
-0.024908818,
-0.006325445,
0.033718806,
0.007200106,
-0.011681158,
-0.002931381,
-0.013221322,
0.0014007249,
-0.0018364707,
0.006056075,
-0.031183558,
-0.008423364,
-0.05425432,
-0.015198816,
0.0010751039,
0.009659297,
0.008119133,
-0.030144107,
-0.002297569,
0.020979183,
-0.016288972,
-0.020573543,
0.008195192,
0.0088733705,
0.018190408,
0.009912822,
-0.0011369005,
-0.017265042,
0.018063646,
-0.015781922,
-0.002894937,
-0.0069972863,
0.020979183,
0.009082528,
-0.007244473,
0.0038123801,
-0.0032989923,
0.00394865,
-0.010952274,
-0.012625538,
0.0012192961,
-0.016174886,
-0.00354301,
-0.0009562641,
-0.036254056,
-0.021866519,
-0.021270735,
-0.022170749,
-0.0045571094,
0.01713828,
-0.042186536,
-0.011484676,
-0.020928478,
0.031665254,
0.04875283,
0.02672152,
-0.0030898342,
-0.018950984,
0.01599742,
-0.027507447,
0.0019790784,
-0.026011651,
-0.009652959,
0.018088998,
-0.012562157,
0.012308632,
-0.0331357,
-0.032146953,
0.018127028,
-0.006927567,
0.0052352883,
0.020725658,
0.010673396,
0.0075930697,
-0.029991992,
-0.017632654,
0.0076881414,
-0.035442777,
-0.024110215,
0.031234263,
-0.010318462,
0.012207222,
0.019039717,
0.022360893,
0.008017723,
0.02692434,
-0.009893808,
-0.040640034,
-0.01805097,
-0.006068751,
0.04190766,
0.0003232442,
-0.020053817,
0.01987635,
0.035544187,
-0.02160032,
-0.0027190542,
-0.02578348,
-0.0076881414,
0.019191831,
-0.018900279,
-0.008676888,
-0.64091086,
-0.0058374098,
0.008594492,
-0.011421295,
0.029713115,
0.024072185,
0.0033718806,
0.012904416,
0.014666413,
0.013183293,
-0.0139311915,
0.023780633,
-0.004737746,
0.012530467,
-0.013246674,
-0.016846728,
-0.001481536,
-0.003961326,
0.009431125,
-0.015338254,
-0.004012031,
0.014704442,
-0.018519992,
0.020193255,
0.0005272525,
-0.01748054,
-0.0017889348,
-0.022310188,
-0.019812968,
0.043504868,
-0.0015163956,
0.01987635,
-0.002658842,
0.021486232,
0.041248497,
-0.019141126,
0.006319107,
0.036355466,
0.0044366852,
0.019407328,
-0.0055553634,
-0.01366499,
0.027101807,
0.0032989923,
0.0042021745,
0.017315747,
0.023970775,
-0.016327001,
-0.0038504088,
-0.010907907,
-0.013424141,
0.015262197,
-0.016301649,
0.0031532154,
0.0109332595,
-0.008499421,
0.028217318,
-0.024908818,
-0.03346528,
0.010679735,
0.0043986565,
-0.002948811,
0.014666413,
-0.0020693967,
0.017049547,
0.009684649,
-0.0117572155,
-0.021536937,
0.007364897,
-0.0043004155,
0.028470842,
0.014488946,
-0.0076437746,
-0.012238912,
0.0047630984,
0.020624248,
0.024655294,
0.022487655,
-0.004804296,
-0.004731408,
0.000055755663,
-0.000081009115,
-0.025834184,
0.0052035977,
0.041679487,
-0.012764976,
-0.025175018,
0.0085437875,
0.013804428,
-0.02101721,
-0.0014767824,
-0.003999355,
-0.022005958,
-0.027913088,
-0.00910788,
0.021435527,
0.0010061768,
0.002604968,
0.052378237,
-0.013715695,
0.00030819117,
-0.0058754385,
-0.008879708,
0.010001556,
0.009272672,
0.013183293,
-0.0550656,
-0.015160787,
0.03937241,
-0.002446515,
0.005171907,
-0.0006084597,
0.01154172,
-0.024198947,
0.008043076,
-0.01683405,
0.0068641854,
-0.0015251104,
-0.0071684155,
-0.03138638,
0.016605878,
0.0018127027,
-0.001415778,
-0.0123339845,
-0.0051307096,
-0.003647589,
0.0226778,
0.005742338,
0.0032641327,
-0.005111695,
0.01855802,
-0.009557887,
0.023134144,
0.013474846,
0.004953242,
-0.009538873,
0.017493216,
-0.011636791,
0.008651536,
-0.026670815,
-0.026341233,
0.014438241,
-0.012948782,
0.005514166,
-0.01190933,
-0.023020057,
-0.0160608,
-0.011472,
-0.04578659,
-0.038332958,
-0.0038409017,
-0.032527238,
-0.015439664,
0.030752566,
0.008081105,
0.005111695,
-0.0073205302,
-0.018190408,
0.0044049947,
-0.0068578473,
-0.00938042,
0.0036666032,
-0.0071050343,
0.0170749,
-0.028521547,
-0.022652447,
-0.023134144,
0.0009776553,
0.009209291,
-0.017772093,
0.0077958894,
-0.005628252,
0.014526974,
0.028952539,
-0.0011527459,
0.0321216,
-0.00489303,
-0.00708602,
-0.013855134,
0.005729662,
-0.0023641193,
-0.010552973,
-0.0036254055,
-0.002685779,
0.005536349,
0.0011305624,
0.035138547,
-0.016491793,
-0.008721256,
0.023641193,
0.012993149,
0.039828755,
-0.006845171,
-0.021904549,
-0.0052035977,
0.0052479645,
-0.015287549,
-0.00698461,
-0.024439797,
0.026062356,
0.055724766,
-0.012967797,
-0.006889538,
0.027558152,
0.040234394,
-0.020510161,
0.003279978,
-0.0053018387,
0.028090555,
-0.002668349,
-0.004338444,
-0.011934683,
0.0014450917,
-0.022791885,
0.0039835093,
-0.0017635823,
0.02324823,
0.008905061,
0.006737423,
0.0061162873,
-0.002536833,
-0.003967664,
0.003333852,
-0.0015845303,
0.021131298,
0.043149933,
-0.0022072508,
-0.006255726,
0.013474846,
-0.024667969,
0.011998064,
0.024629941,
-0.014577679,
0.029434236,
0.0043986565,
0.020611571,
-0.009564226,
-0.021435527,
0.017987588,
0.021891871,
0.0034067403,
0.012771315,
0.0051338784,
-0.019407328,
0.043859802,
-0.022551037,
0.038586482,
-0.019014364,
0.019483386,
0.048372544,
0.0033623734,
-0.009583239,
-0.011136079,
0.008417025,
-0.0150847295,
-0.012074121,
0.013918515,
-0.005007116,
0.021131298,
0.022170749,
0.014856557,
0.0013975558,
0.0010125149,
-0.008201529,
0.0052606408,
0.018481962,
0.0060750893,
0.008283925,
0.005491982,
0.0065282653,
-0.044113327,
0.0123656755,
-0.010882555,
-0.036279406,
0.021283412,
-0.0030074387,
0.01713828,
0.020586219,
0.0122515885,
0.011262842,
-0.0086261835,
-0.04885424,
0.0036254055,
0.006033892,
-0.006794466,
-0.021435527,
0.007497998,
0.00090714364,
0.004636336,
0.0018031956,
0.02253836,
0.010293109,
-0.038409017,
-0.0011788906,
-0.0048771845,
-0.00044446078,
0.022905972,
-0.00856914,
0.0105212815,
-0.026949693,
0.000325621,
0.0063919956,
-0.0051687383,
0.0031468773,
-0.016098829,
0.01083185,
-0.012885401,
-0.009088866,
-0.011472,
-0.01144031,
0.026366586,
-0.031969484,
0.010185361,
0.016238267,
0.008493083,
0.037369564,
-0.026239824,
-0.000021589227,
0.008429701,
0.009044499,
0.004953242,
-0.01488191,
-0.0050388067,
-0.035772357,
0.037572384,
0.011155094,
-0.022563713,
-0.00019053978,
0.015072053,
-0.009545211,
-0.0086261835,
-0.034327265,
0.032070894,
0.025352485,
0.0023863027,
-0.01407063,
0.037876613,
0.02146088,
0.02416092,
0.038206197,
0.018583372,
-0.015617131,
0.010058599,
0.008676888,
0.027279275,
-0.022614418,
0.017936883,
0.045634475,
0.018811544,
-0.008340968,
-0.0068641854,
0.035341367,
-0.011136079,
-0.006119456,
0.0019125282,
0.02277921,
-0.022589065,
0.005523673,
-0.013272027,
-0.0069592576,
0.0028252178,
-0.0062779095,
-0.0033718806,
0.0106860725,
0.03397233,
0.022170749,
0.014679089,
0.022107368,
-0.0098621175,
-0.013449494,
0.019850997,
0.0011028332,
0.011934683,
-0.01052762,
0.0040437216,
0.016124181,
0.00910788,
-0.018304495,
0.008448716,
-0.0032340265,
-0.0008508928,
-0.040944267,
-0.012308632,
0.022386245,
-0.026975045,
0.0022294342,
-0.0012137502,
-0.016136857,
-0.011554396,
-0.0010006309,
0.0046553505,
-0.010286772,
-0.01427345,
-0.0060148775,
0.0120867975,
-0.007922652,
-0.02662011,
0.004360628,
0.008733932,
0.03916959,
0.02824267,
-0.027203217,
-0.018241113,
0.024186272,
-0.017518569,
-0.0049849325,
-0.031031443,
-0.0063888263,
-0.012834696,
0.0023815492,
-0.01575657,
-0.0018982674,
0.0039232974,
0.01713828,
-0.0021375315,
-0.006407841,
0.00600537,
-0.016035447,
0.006138471,
0.0103564905,
-0.008201529,
-0.0040532285,
-0.027558152,
0.0036666032,
0.015972067,
-0.041071028,
-0.011839611,
-0.0115924245,
-0.014463593,
-0.01801294,
0.009069852,
-0.014780499,
-0.006154316,
0.009551549,
0.0063317833,
-0.0017334763,
0.026544053,
0.014286126,
0.0053335293,
0.017125605,
0.007035315,
0.0030724045,
0.029738467,
-0.01012198,
-0.012321308,
0.01967353,
0.03138638,
-0.013588932,
-0.025618687,
0.011053684,
0.024667969,
-0.022817237,
-0.038307607,
-0.008112796,
0.012733286,
0.060896672,
0.0124987755,
0.0124987755,
-0.049944397,
0.0068008043,
-0.018672107,
-0.021815814,
-0.018405905,
0.0051814145,
-0.012257927,
0.015908685,
-0.028775072,
-0.034910373,
0.039803404,
-0.030422984,
-0.01666926,
-0.025491925,
-0.027786326,
0.0024813747,
0.006144809,
-0.005941989,
-0.027989145,
-0.013069207,
0.016301649,
-0.024629941,
-0.019458033,
-0.0209158,
0.009418448,
0.016200239,
0.017049547,
0.029560998,
0.027355332,
-0.00035592515,
-0.011218475,
-0.0066043227,
0.0054476154,
-0.0077451845,
-0.026670815,
0.030853976,
-0.012860049,
-0.010400858,
-0.009158585,
0.014957967,
0.010147332,
0.027152512,
-0.010280433,
-0.03384557,
-0.021372145,
-0.04751056,
0.03447938,
-0.008309278,
-0.011408619,
-0.0027681745,
-0.014932615,
-0.0010101381,
0.02125806,
-0.023451049,
0.0040088617,
0.0086261835,
0.015008672,
0.017772093,
-0.006395165,
-0.025720097,
-0.0054444466,
0.0023229215,
0.010508605,
-0.0016922784,
-0.0045888,
0.015579103,
0.008138148,
0.007567717,
0.0038979447,
-0.006049737,
-0.030118754,
0.02743139,
-0.030955385,
0.029003244,
-0.0064775604,
-0.014945291,
-0.017429834,
-0.0017049547,
-0.033008937,
0.001024399,
-0.00678179,
0.010476915,
-0.0062430496,
0.0036317436,
-0.0239581,
-0.017987588,
-0.012384689,
-0.029611703,
0.00833463,
-0.016846728,
0.026265176,
-0.0015219414,
-0.0067564375,
0.0080494145,
0.007250811,
0.005827903,
-0.021410175,
0.018507315,
0.004167315,
-0.006566294,
-0.0008326707,
-0.010793821,
0.0051909215,
-0.0315892,
-0.034428675,
0.01845661,
0.029231416,
-0.0078846235,
0.006731085,
-0.017467864,
-0.010939598,
0.019369299,
-0.030448336,
0.017150957,
-0.008283925,
-0.019179156,
0.0051243715,
0.022094691,
-0.032248363,
0.01575657,
-0.04038651,
0.02277921,
-0.0035366719,
0.007314192,
0.0054095867,
-0.007358559,
0.0116748195,
0.009925499,
-0.01126918,
-0.004908875,
-0.013449494,
-0.008423364,
-0.008017723,
-0.0013072375,
-0.01821576,
0.038003378,
0.020066492,
0.002351443,
0.007814904,
-0.019077746,
-0.018279143,
-0.006895876,
-0.012029755,
-0.01693546,
-0.0014466762,
-0.003549348,
0.027558152,
0.00052210275,
-0.0026097216,
0.0021533768,
-0.019787615,
-0.013031178,
0.004595138,
-0.0082966015,
-0.008816327,
-0.029003244,
0.0017968575,
-0.022551037,
-0.016618555,
-0.0029155358,
0.008575479,
-0.006731085,
0.0048676776,
0.0010624276,
-0.015198816,
0.0014363768,
0.02436374,
0.013195969,
-0.013119912,
-0.0032514564,
-0.0022563713,
-0.04875283,
0.010071275,
0.005257472,
-0.035392072,
0.0051370477,
-0.0017524906,
-0.0066360133,
-0.013829782,
-0.02540319,
0.052124713,
-0.015579103,
-0.0013048608,
-0.0074663074,
-0.025022903,
0.029611703,
-0.021283412,
0.012067784,
0.024249652,
-0.013335408,
-0.004937397,
-0.0010434133,
0.021536937,
-0.0143114785,
-0.011053684,
0.0060433988,
-0.0122515885,
0.040640034,
-0.008695903,
0.0067120707,
0.0048898607,
-0.02176511,
-0.026670815,
0.023451049,
-0.005748676,
-0.0077325082,
0.00620819,
0.008448716,
0.005073666,
0.0034732907,
-0.000887337,
0.0014688596,
-0.0068008043,
-0.024338387,
0.0007510674,
0.0011234321,
-0.00041475083,
0.007098696,
0.020104522,
0.008575479,
-0.02028199,
-0.023780633,
-0.038510427,
0.020231284,
0.0056948024,
0.0036349127,
0.03977805,
0.013094559,
-0.026696168,
0.010052261,
0.009272672,
0.0015005503,
-0.010369167,
0.031437084,
-0.0024480994,
-0.005799381,
0.015173463,
0.017810121,
-0.01012198,
-0.014691765,
0.017214337,
-0.014387536,
-0.0023197525,
0.010470577,
-0.020003112,
0.022069339,
0.0060655824,
-0.0076374365,
0.008347306,
0.007656451,
-0.010045922,
-0.016327001,
0.0046204906,
-0.02355246,
0.016491793,
-0.010793821,
-0.007719832,
-0.008752946,
0.008581816,
-0.0093677435,
-0.043783743,
-0.017125605,
-0.008486745,
-0.027304627,
0.0029187049,
0.011586086,
-0.0003890022,
0.020205932,
-0.021029888,
0.0075360266,
-0.013069207,
-0.010514944,
0.0013183292,
-0.0013373436,
0.0096149305,
-0.015490369,
-0.008353644,
0.012809344,
0.034301914,
-0.0072127823,
0.012131165,
-0.021752434,
-0.016605878,
-0.016922785,
0.035569537,
-0.009874794,
0.009139571,
0.03376951,
-0.0021787293,
-0.041324552,
-0.02976382,
-0.01855802,
0.0023672883,
-0.015211492,
-0.00023866989,
0.0078973,
0.0022009127,
-0.0010442055,
0.022563713,
0.006502913,
-0.037775204,
0.0005446823,
0.15931502,
0.010007894,
-0.019343946,
0.016593203,
-0.0044652065,
0.007852932,
0.04555842,
0.0006928359,
0.012644553,
0.020383399,
0.01221356,
0.0056092376,
-0.020104522,
0.0037616752,
0.019280566,
-0.040766798,
-0.02257639,
-0.019369299,
0.0030343756,
-0.03602588,
0.002841063,
0.0094501395,
0.0045666164,
-0.011801583,
0.035949826,
0.026797578,
0.02298203,
-0.0036190674,
0.044341497,
0.009507182,
-0.022221453,
0.019622825,
-0.011579748,
0.013018502,
-0.0038282254,
-0.01666926,
-0.0012470254,
-0.00867055,
-0.017721388,
0.0014648983,
-0.028090555,
0.005976849,
-0.0040088617,
0.029231416,
-0.002105841,
0.043707687,
0.010261419,
-0.009088866,
0.01366499,
0.02044678,
-0.039600585,
-0.024275005,
-0.007314192,
0.027482094,
-0.0015892839,
-0.007371235,
0.022893295,
0.015439664,
-0.013779076,
0.0026002144,
-0.011782568,
0.008486745,
-0.032856822,
0.014083306,
-0.010736777,
0.027710268,
-0.017024195,
0.0143114785,
-0.026898988,
0.012276942,
-0.00823322,
-0.034986433,
-0.011858625,
0.002166053,
0.014349507,
-0.0051909215,
0.027203217,
0.0013698265,
-0.012232575,
0.0012026585,
-0.0131579405,
0.009298025,
-0.002166053,
0.000090813395,
-0.012505114,
-0.012441733,
0.01535093,
0.040766798,
-0.014539651,
0.0027253923,
0.0009237812,
-0.024959523,
0.003600053,
-0.013284703,
0.00209158,
0.00012775276,
-0.0034669526,
0.000328592,
0.0014656906,
0.009500844,
-0.03954988,
0.06414179,
0.001182852,
-0.000337505,
-0.004943735,
0.008068428,
-0.01589601,
0.010001556,
0.018177733,
0.011072698,
-0.008765622,
-0.00268261,
0.0062842476,
-0.0126635665,
-0.016580526,
0.018849574,
0.012124826,
-0.029130006,
-0.013005826,
0.008968442,
0.0037775205,
-0.020307342,
0.011883978,
0.010578325,
-0.0036190674,
-0.02314682,
-0.008898723,
-0.0006100442,
-0.0044588684,
-0.037547033,
0.029434236,
-0.026645463,
-0.0030216994,
0.0028838452,
-0.006217697,
0.008993794,
0.012771315,
-0.008657874,
0.020015787,
0.009893808,
-0.008588155,
-0.023603166,
0.010914246,
0.0055458564,
0.010755792,
-0.0010505436,
-0.012352999,
-0.010977627,
-0.023729928,
0.021283412,
-0.018710135,
-0.01811435,
0.017924208,
-0.0018634078,
0.016136857,
-0.016656583,
-0.008372659,
-0.03427656,
0.00058548397,
0.017100252,
-0.030600451,
0.044392202,
0.027989145,
-0.020003112,
0.023387669,
0.008277587,
-0.15475157,
0.015832627,
-0.0072698253,
0.002365704,
0.03356669,
0.021296088,
0.013284703,
-0.0031357857,
0.000606479,
-0.013373436,
-0.0014276619,
0.009931836,
0.0075423648,
-0.0074726455,
0.019166479,
0.0014213237,
-0.0058786077,
0.025390515,
0.011414957,
0.023983452,
0.0038789304,
-0.038586482,
0.0134875225,
-0.01703687,
0.00041395857,
-0.02253836,
-0.0275328,
0.022614418,
-0.015110082,
0.003539841,
0.0014910431,
0.009272672,
0.013715695,
-0.0019378806,
0.028521547,
-0.002142285,
-0.022766532,
-0.020003112,
0.0012121657,
-0.00046149446,
0.030169459,
-0.0018269635,
0.017860826,
0.021967929,
0.0052923313,
0.017632654,
0.012917092,
-0.0109332595,
0.013880487,
0.023767956,
0.014831205,
-0.024883466,
-0.014894586,
0.0056060683,
0.008676888,
0.02743139,
0.010762131,
-0.013614285,
0.01116777,
-0.027760973,
0.00012824794,
-0.0336681,
0.024338387,
0.015921362,
0.0050990186,
-0.016352354,
-0.009139571,
0.0004813011,
-0.0049785944,
0.02095383,
-0.024414444,
-0.034301914,
0.009469153,
-0.021777786,
0.0052828244,
0.020763686,
0.00094834145,
0.023742603,
-0.021942576,
-0.007440955,
-0.02034537,
0.030853976,
-0.021080593,
-0.015363607,
0.000005997695,
-0.011871302,
0.02763421,
-0.023577813,
0.0068578473,
-0.022627095,
0.0075930697,
-0.021308765,
0.003283147,
-0.018469287,
-0.005412756,
-0.012676243,
-0.0007399757,
-0.000024795425,
-0.0011297702,
0.027760973,
-0.00020153246,
0.017011518,
-0.020193255,
-0.004411333,
0.039397765,
0.004240203,
-0.0027444067,
0.0103248,
0.021866519,
0.0018855912,
-0.02243695,
0.018127028,
0.007307854,
0.020586219,
-0.004325768,
0.008220544,
0.008321954,
0.008664212,
0.0044081635,
-0.00863886,
0.06926299,
0.015224168,
-0.0020725657,
-0.00698461,
0.005209936,
-0.018735487,
-0.11753412,
-0.026949693,
-0.006718409,
-0.008087443,
0.0038504088,
0.007200106,
-0.006458546,
0.024148243,
0.015224168,
0.022005958,
-0.03762309,
-0.02253836,
0.0034320927,
-0.0139311915,
0.023260906,
-0.022094691,
0.0048423246,
-0.00124861,
-0.033592045,
0.03384557,
-0.012143841,
0.00008759482,
-0.02223413,
0.005419094,
-0.009557887,
0.014045278,
-0.002449684,
-0.011161432,
0.016415736,
0.020383399,
0.0007276956,
0.008924075,
0.01646644,
0.023324287,
0.0011891901,
-0.006914891,
0.0031215248,
-0.019850997,
0.02081439,
-0.049209177,
0.004737746,
0.0206496,
0.032273713,
0.00593882,
0.010489591,
0.0070733437,
-0.034606144,
0.013601609,
0.011579748,
0.023324287,
-0.010331138,
-0.015946714,
-0.020636924,
-0.023729928,
0.021511585,
0.023235554,
-0.0070670056,
-0.0012232575,
-0.0009229889,
0.024439797,
0.018127028,
-0.01336076,
-0.008119133,
0.019445358,
0.021232707,
-0.01993973,
-0.021955254,
-0.022728505,
0.010362829,
0.0049310587,
0.01498332,
-0.0008928829,
-0.0072317966,
-0.0015156033,
-0.016694613,
0.032552592,
0.008936752,
-0.02142285,
-0.0056028995,
-0.0032736398,
-0.011446647,
-0.014349507,
0.011281856,
-0.018076323,
0.0072317966,
0.040006224,
0.0065346034,
-0.008733932,
0.0030422984,
-0.01801294,
0.025960946,
0.013170617,
0.030194812,
0.0025463402,
0.029231416,
-0.012454409,
-0.007605746,
0.006154316,
0.021410175,
0.022031311,
0.0026762718,
-0.0275328,
-0.020256637,
0.029637055,
0.010635368,
0.0024591913,
0.022703152,
0.0070036245,
0.021346793,
0.0033496972,
0.0003648381,
0.005273317,
-0.0024179933,
0.002408486,
0.0054951515,
0.011446647,
0.0006817442,
0.014704442,
0.016757993,
0.0157946,
0.023374991,
-0.0036190674,
-0.024984876,
0.0157946,
-0.008207868,
0.030296221,
-0.016377706,
0.020167902,
0.011414957,
0.029307473,
-0.04038651,
0.020535514,
-0.004750422,
-0.026544053,
0.0089557655,
0.021574967,
-0.01569319,
-0.045228835,
-0.0071240487,
0.035366718,
-0.0011749293,
0.041552726,
-0.022817237,
-0.021067915,
0.0022151736,
-0.021980606,
0.0014894586,
0.0067564375,
-0.030651156,
0.018380553,
0.009963527,
-0.020472134,
0.014565003,
-0.0106036775,
0.00354301,
-0.022120044,
-0.038637187,
0.009811413,
0.020573543,
0.019001689,
-0.00029353425,
-0.009570563,
0.0035556862,
0.004908875,
-0.015579103,
-0.01811435,
0.01865943,
-0.017505892,
-0.017442511,
0.030575098,
-0.0023973945,
0.0073205302,
-0.009748031,
-0.0065979846,
-0.0047567603,
0.005786705,
0.016441088,
0.025149666,
0.007662789,
0.0055965614,
-0.008074767,
0.0036380817,
-0.014298802,
-0.004417671,
-0.02578348,
0.0068134805,
0.016605878,
0.0027713436,
-0.017924208,
0.02763421,
-0.018786192,
0.004474714,
0.018101675,
-0.023070762,
0.0014617293,
0.009215629,
0.024921494,
0.02672152,
-0.032375123,
-0.014831205,
-0.007979695,
0.02996664,
0.0011979049,
0.013183293,
-0.016986165,
-0.018367875,
-0.008315615,
0.013449494,
-0.03356669,
-0.016517146,
-0.023527108,
-0.0022611248,
0.013943868,
0.039499175,
-0.013183293,
-0.015426988,
0.017911531,
-0.025415868,
-0.012162855,
0.0091776,
0.0063317833,
0.0063793194,
0.014146687,
0.0072761634,
0.014932615,
-0.015807275,
0.02034537,
0.0072191204,
0.028065203,
-0.046445753,
0.024452472,
-0.0056250826,
0.035316013,
0.01947071,
-0.038713247,
0.016174886,
-0.005273317,
-0.035493482,
-0.03640617,
0.034099095,
-0.0021296088,
0.052378237,
-0.027076455,
-0.0051845834,
-0.012828358,
-0.019445358,
0.011586086,
-0.0018095337,
-0.0074663074,
-0.010711425,
-0.022056663,
0.012441733,
-0.012327647,
0.0099445125,
-0.04467108,
-0.016517146,
0.009196614,
-0.014298802,
0.023565136,
-0.017049547,
-0.030549746,
0.0285469,
0.013994573,
0.004262387,
-0.015667837,
-0.014501622,
0.0042877393,
0.0033528663,
-0.017835474,
-0.014197392,
-0.013601609,
-0.015186139,
-0.00296941,
-0.015477693,
0.0044525303,
0.017696036,
-0.00489303,
-0.0005688464,
-0.0196355,
0.0096149305,
0.030575098,
-0.025986299,
0.012207222,
-0.0057233237,
-0.025758127,
-0.0098621175,
-0.052479647,
0.0058247335,
-0.007764199,
-0.018634077
] |
The Polycomb Group (PcG) of chromatin modifiers regulates pluripotency and differentiation. Mammalian genomes encode multiple homologs of the Polycomb repressive complex 1 (PRC1) components, including five orthologs of the Drosophila Polycomb protein (Cbx2, Cbx4, Cbx6, Cbx7, and Cbx8). We have identified Cbx7 as the primary Polycomb ortholog of PRC1 complexes in embryonic stem cells (ESCs). The expression of Cbx7 is downregulated during ESC differentiation, preceding the upregulation of
|
[
-0.019989772,
-0.013366574,
-0.0153562045,
-0.041181333,
-0.025998723,
0.020243483,
-0.01836068,
0.00785837,
-0.0063027204,
-0.010809433,
0.010862846,
-0.004820513,
0.005421408,
0.011637332,
-0.016571349,
0.008419206,
0.01956247,
-0.021939343,
-0.0011817601,
0.023862207,
-0.011096527,
-0.0076914555,
-0.00994815,
-0.02822871,
-0.014568364,
0.001154219,
0.02105803,
-0.029483913,
0.019455643,
-0.0033600044,
0.007511187,
0.021578806,
-0.0036687974,
-0.0037989914,
-0.031700548,
-0.007965197,
-0.006352795,
0.0038190214,
-0.000908019,
0.010675901,
0.033623412,
0.017025357,
-0.0073643015,
0.021445272,
-0.00990809,
-0.005678457,
0.00024202713,
-0.00553491,
-0.02718716,
0.017292421,
-0.009814617,
0.01686512,
-0.0047070105,
-0.004960722,
-0.03287563,
0.0021582143,
0.027694581,
0.024863698,
0.013873997,
0.0006664092,
0.0009188685,
-0.0019846226,
-0.011644009,
0.005765253,
-0.004893956,
0.031620428,
-0.0014413133,
-0.00057293667,
0.029670857,
-0.0043798564,
0.039311882,
0.012278287,
-0.007350948,
-0.014127708,
0.004069394,
-0.0277747,
-0.035572983,
0.004446623,
-0.008639534,
0.0062292777,
0.020537253,
-0.009854677,
0.0034417927,
0.0041161305,
0.0044966973,
0.0030378578,
0.020296896,
0.0111032035,
0.0053112437,
0.0045834933,
0.025718303,
0.04633568,
0.04385198,
-0.007798281,
-0.016144045,
-0.0020046523,
0.008092052,
0.03204773,
-0.007798281,
-0.017546132,
-0.0019445629,
0.012672207,
-0.025558066,
-0.013480077,
-0.017492719,
-0.0022032815,
0.004930677,
-0.010529015,
0.016197458,
0.005448114,
-0.038190212,
0.038029972,
-0.0058320193,
-0.036801476,
0.02607884,
-0.03453143,
0.0062927054,
-0.00044524646,
-0.01160395,
-0.0157568,
0.019869594,
0.022914128,
0.0077181617,
-0.052344628,
-0.003652106,
0.0037989914,
-0.0019645926,
0.016477875,
-0.007284182,
-0.00906016,
0.016517935,
0.0048605725,
-0.010135095,
0.009794588,
-0.02428951,
-0.014688543,
-0.007784928,
-0.0047837915,
-0.0009998224,
-0.030845942,
0.017733078,
0.01309951,
-0.017025357,
-0.019161873,
0.00093889836,
0.015075787,
0.0012526991,
0.0016182435,
0.019121813,
0.017372541,
0.01670488,
0.0016800022,
0.027013566,
0.003708857,
0.02205952,
0.013460047,
0.02499723,
0.020483842,
0.0014763655,
-0.020163365,
-0.0018928191,
-0.004319767,
0.026532851,
0.0042496626,
0.023808794,
0.019215286,
0.0022867392,
-0.009213722,
0.0023685277,
-0.011116557,
0.010816109,
0.014421479,
-0.05496186,
0.009620996,
-0.017786492,
-0.01571674,
-0.009393991,
0.0067333616,
-0.021071384,
0.0023985724,
-0.008245614,
-0.005020811,
0.00636281,
0.013560196,
-0.032101143,
-0.01189772,
0.0079718735,
-0.024169331,
-0.003608708,
-0.026920093,
0.0064128847,
0.008058669,
0.018293913,
-0.024943817,
-0.6178803,
-0.019348817,
0.012138078,
-0.027427517,
0.011370268,
0.04513389,
0.030124867,
-0.012118048,
-0.017385894,
0.015195966,
-0.00014678111,
0.00037430748,
0.026666382,
-0.00835244,
-0.025170822,
-0.043504793,
0.008051992,
-0.01303942,
0.03971248,
0.016785,
-0.02627914,
-0.0022867392,
-0.01985624,
0.013740465,
0.0061591733,
-0.0006392855,
0.03800327,
-0.011003055,
-0.0011200014,
0.026653029,
-0.0024920448,
0.036080405,
-0.016063925,
-0.0070237946,
0.045000356,
0.027053626,
-0.022647064,
0.011997869,
0.023328077,
0.06073045,
-0.0034034022,
0.003455146,
0.02031025,
-0.009814617,
-0.01981618,
0.020203425,
-0.00059672206,
0.021418568,
0.0052711843,
0.00055207225,
-0.020537253,
-0.014127708,
0.0034484693,
-0.017065417,
0.013319838,
0.006856879,
0.021218268,
0.0015723418,
0.007591306,
-0.012471909,
0.0058253426,
0.0261189,
-0.016758293,
-0.016157398,
-0.016237518,
0.02458328,
-0.011370268,
-0.004693657,
0.012091341,
-0.009187017,
0.0129392715,
0.014167768,
0.0004794641,
0.009921444,
0.003949215,
0.033222813,
0.010829463,
-0.010862846,
0.0020814333,
0.012077989,
0.009353931,
-0.0071239434,
-0.019055046,
0.012572058,
0.019014986,
-0.010395483,
-0.016184105,
0.023822147,
-0.005584985,
-0.0056817955,
0.018908162,
0.014141061,
-0.0029560693,
-0.010388806,
-0.020069892,
-0.004723702,
0.0024019107,
0.0056918105,
-0.00009994052,
-0.02263371,
-0.005294552,
-0.0014471554,
-0.01073599,
-0.0042296327,
-0.0005504031,
0.0011942787,
-0.03843057,
0.0109496415,
0.043825272,
-0.026572911,
-0.0118376305,
-0.01832062,
0.0035352653,
0.007043824,
0.000084553016,
-0.029270262,
0.004503374,
-0.0013987499,
-0.023154486,
-0.02507735,
0.0054915124,
-0.017813196,
-0.0042596776,
-0.021832516,
0.043050785,
0.01235173,
0.005047518,
-0.0051643583,
0.0019829534,
-0.0022583636,
0.026359258,
-0.0045634634,
0.016063925,
-0.017105477,
0.012879182,
0.012665531,
0.006516372,
-0.006135805,
0.025237588,
-0.027534341,
-0.0294305,
-0.023528377,
-0.008699624,
-0.013767171,
0.019095106,
-0.023688614,
-0.014060942,
0.00906016,
0.028923078,
0.012759003,
0.022620358,
-0.025170822,
0.0000511178,
0.010769373,
0.0071239434,
-0.0013152923,
-0.021111444,
-0.017973436,
-0.0040827473,
-0.025331061,
-0.0046001845,
-0.008686271,
-0.027614461,
0.003805668,
-0.0031947582,
-0.021538746,
-0.00906016,
0.021779103,
-0.012124725,
-0.009714468,
0.004626891,
0.00024724324,
-0.0116840685,
0.014381419,
-0.012345053,
0.0068368493,
0.0059021236,
0.0034384546,
-0.0022049507,
-0.015182612,
-0.0107560195,
-0.017920023,
-0.012104695,
-0.023194546,
0.04323773,
0.0015189289,
0.024075858,
0.011697422,
0.021418568,
0.02491711,
-0.0103687765,
0.017279068,
-0.019295406,
0.017759785,
-0.009313872,
-0.03159372,
0.015770154,
0.0074510975,
-0.00050575327,
0.034184247,
0.027908232,
-0.024169331,
0.018133674,
-0.03357,
0.016304282,
-0.04991434,
-0.001508914,
-0.012445202,
-0.0075178635,
0.016437816,
0.0034084097,
0.010889552,
-0.00035427764,
-0.010041622,
0.002261702,
0.010455572,
-0.022420058,
0.004112792,
-0.023515023,
-0.0050875773,
-0.0054648058,
-0.019669294,
0.021111444,
0.0069236453,
-0.0107159605,
0.008212231,
0.006997088,
0.015690034,
-0.00080453156,
0.00713062,
-0.012057959,
0.025771717,
-0.0033499894,
-0.02089779,
-0.007197386,
0.01816038,
0.03244833,
-0.005277861,
0.026426025,
-0.020403722,
-0.011971163,
0.012498615,
0.0069837347,
0.005344627,
-0.026519498,
-0.022273174,
0.019509057,
0.011003055,
-0.011570566,
0.02499723,
-0.020710846,
-0.0038323745,
-0.018400738,
-0.0018711202,
0.012999361,
-0.003268201,
0.009213722,
0.021325095,
0.045374244,
0.014982314,
-0.00035991104,
-0.03121983,
-0.0020947866,
-0.0022934158,
0.02147198,
0.003992613,
0.002677321,
-0.003344982,
-0.026479438,
-0.022860715,
-0.006099084,
0.0069236453,
0.010635841,
-0.032154556,
0.016090631,
-0.004513389,
-0.0087063005,
0.0043164287,
0.013166276,
0.007998579,
0.013873997,
-0.032181263,
0.02296754,
0.02105803,
-0.010041622,
0.0021966049,
-0.042356417,
0.008773066,
0.010048299,
0.0026272463,
0.015770154,
0.0062259394,
0.00079451664,
0.0047504087,
-0.004560125,
-0.012471909,
-0.0007782424,
-0.012191491,
0.015075787,
-0.01579686,
0.0071640033,
-0.0039425385,
0.0024186021,
-0.008539385,
0.03519909,
0.0041495133,
-0.005094254,
-0.0037121954,
0.004656936,
-0.0022132965,
-0.011363591,
-0.01349343,
-0.0011508807,
-0.022460118,
-0.013687052,
0.0066298745,
-0.011056467,
-0.0042663543,
0.029911216,
0.018000143,
-0.032902338,
-0.022753889,
0.006536402,
-0.0030762483,
0.022860715,
0.01786661,
-0.01303942,
0.0109496415,
-0.004613538,
-0.00551488,
-0.042356417,
-0.016945237,
0.009560906,
-0.01158392,
-0.020216778,
0.019468997,
-0.0059955963,
-0.006823496,
0.00835244,
0.005801975,
-0.0024403012,
-0.023221252,
-0.023661908,
-0.013967469,
-0.011650685,
0.012598764,
0.013373251,
0.038537398,
0.03092606,
0.012672207,
-0.001459674,
0.023768734,
0.00008330115,
-0.00785837,
-0.0049941046,
0.013106187,
0.004146175,
0.006289367,
0.007103914,
-0.030204987,
0.025384475,
0.027614461,
-0.0061524967,
0.015983805,
0.018787982,
0.024796931,
0.017399248,
-0.0049006324,
0.004036011,
0.0033867108,
-0.016758293,
0.0011984516,
-0.015115847,
-0.01973606,
0.01355352,
-0.029644152,
0.00067558954,
-0.00376227,
0.00045943426,
-0.022379998,
0.0029594076,
-0.007264152,
-0.005541587,
-0.025157468,
-0.0044866824,
-0.0131328935,
-0.0011583919,
-0.0165847,
-0.006069039,
-0.02420939,
0.012438525,
-0.028656013,
-0.008833156,
-0.018721215,
0.005084239,
-0.031567015,
-0.032394916,
-0.0010473933,
0.018948222,
0.031273246,
0.036080405,
-0.01948235,
-0.0030245045,
0.027587755,
0.011263442,
-0.047484055,
0.014728603,
-0.030658996,
0.010248598,
0.0005391363,
0.01114994,
-0.005668442,
-0.02209958,
0.0050575323,
0.004800483,
-0.012491939,
0.014581718,
-0.009293842,
-0.009347255,
0.027561048,
0.0054948507,
0.034024008,
0.015249379,
-0.020043185,
-0.006603168,
-0.02889637,
-0.0030378578,
-0.023020953,
0.004089424,
0.005047518,
-0.010121741,
0.005905462,
-0.030285105,
-0.015730094,
0.008866539,
-0.028015058,
-0.005611691,
0.002830883,
0.028282123,
0.009260459,
-0.019963065,
0.018253854,
-0.01102976,
-0.012358407,
0.019976418,
-0.01475531,
0.019455643,
0.0060657007,
-0.03154031,
-0.002602209,
-0.029991334,
-0.023902265,
-0.011156617,
0.009941474,
-0.01806691,
0.039392002,
-0.0136736985,
-0.005454791,
-0.0067266854,
0.021071384,
-0.012238228,
0.018440798,
-0.0033850416,
-0.013727112,
-0.014474892,
0.027427517,
0.014114355,
-0.02076426,
-0.009106897,
-0.034024008,
0.00078116346,
0.024756873,
0.016090631,
0.015516443,
0.005925492,
0.0009197031,
-0.012905888,
-0.020363662,
-0.020417076,
-0.0435315,
0.001979615,
-0.018173734,
0.042970665,
0.02184587,
0.048525605,
0.015236026,
-0.010502309,
0.031807374,
0.022166347,
0.017425954,
-0.010508985,
0.026319198,
-0.022620358,
0.033863768,
-0.018480858,
-0.0069637047,
0.025598126,
-0.00052995596,
0.024035798,
0.040353436,
-0.032154556,
-0.02897649,
0.02462334,
-0.02868272,
-0.029564032,
-0.00079952413,
-0.016557995,
0.0046769655,
-0.041555226,
-0.0064362525,
0.017960083,
0.027000213,
0.007391008,
-0.0012877512,
0.014114355,
-0.012825769,
0.037469137,
-0.006603168,
0.0047671,
-0.0071372967,
-0.003652106,
0.002909333,
-0.015316145,
0.004293061,
-0.0058220043,
0.041234747,
0.0056350594,
-0.023782087,
-0.008212231,
0.0153562045,
-0.008652887,
-0.01301939,
-0.00594886,
-0.016598053,
-0.023408197,
-0.026559558,
-0.01471525,
-0.038190212,
0.0055949995,
0.010502309,
-0.024423042,
0.030124867,
0.018787982,
-0.0153562045,
0.013052774,
-0.005992258,
0.03957895,
-0.012738973,
0.014808723,
0.018881455,
-0.0003932941,
0.0044866824,
-0.023928972,
-0.016157398,
-0.0015957099,
0.051596846,
0.034798495,
-0.006289367,
-0.008733007,
-0.0075646,
-0.009240429,
-0.016464522,
-0.03933859,
0.00060214684,
-0.001416276,
0.01237176,
0.022473471,
0.010869523,
-0.016344342,
-0.02330137,
-0.004800483,
0.007477804,
-0.003738902,
-0.024609987,
-0.008078699,
0.0058854325,
-0.014928902,
0.0026856665,
0.02615896,
-0.010669224,
0.00036262342,
-0.006195895,
0.010375453,
-0.0002518334,
-0.01558321,
0.01388735,
-0.0038857874,
-0.0030328503,
0.0070371474,
0.0061057606,
-0.012184815,
-0.0033817033,
-0.0017759785,
0.047030047,
-0.0064562825,
0.0034851907,
0.0008112082,
0.0075712763,
0.030605583,
0.009974856,
-0.008692947,
-0.018667804,
-0.032261383,
-0.008459265,
0.005868741,
0.014408126,
-0.011550536,
0.007684779,
-0.024556573,
-0.0076914555,
-0.0331694,
-0.019936359,
-0.0033049223,
-0.040513672,
0.007030471,
0.00047779494,
0.014862135,
0.02454322,
0.012178138,
0.008145465,
-0.00557497,
0.008092052,
0.0011775872,
0.027334044,
0.016184105,
0.0061324667,
-0.037202075,
0.01388735,
-0.0052611693,
-0.031113006,
-0.0023434903,
-0.02814859,
-0.015703388,
0.011844307,
-0.008733007,
0.026559558,
0.007945167,
-0.037068542,
-0.0033433128,
0.005618368,
0.028656013,
-0.017706372,
0.0025638186,
-0.000057950892,
-0.015730094,
-0.02027019,
0.012451879,
-0.01309951,
-0.008459265,
-0.0052511543,
-0.012986008,
0.020884437,
-0.03469167,
0.0017893317,
-0.023101073,
0.0044399463,
0.02080432,
0.009734498,
-0.044332694,
-0.019001635,
-0.015997158,
0.008158818,
-0.014635131,
0.007511187,
-0.01820044,
0.013126217,
-0.012658854,
0.010001563,
-0.03640088,
-0.0074043614,
0.00717068,
-0.050261524,
-0.044466227,
0.008826479,
-0.024262803,
0.05060871,
0.006713332,
-0.011757512,
-0.0135201365,
-0.012578734,
-0.04294396,
-0.048979614,
0.005468144,
0.023581788,
-0.006222601,
-0.0038657575,
0.0032965764,
-0.0034351163,
0.0051777116,
0.017025357,
-0.00065764616,
-0.02838895,
-0.008799773,
-0.004987428,
0.018881455,
0.0069236453,
-0.02060402,
-0.013646992,
0.029457206,
-0.0021932665,
-0.01158392,
0.051009305,
-0.009520846,
0.05335947,
-0.019161873,
0.026572911,
0.02586519,
0.02844236,
0.021832516,
-0.016304282,
0.0021832518,
0.016437816,
0.0037322254,
0.0024836992,
0.0038791108,
-0.019709354,
-0.016344342,
0.0068268343,
-0.00017807772,
0.0013328184,
0.0067734215,
-0.00066390546,
0.009213722,
0.003618723,
0.01948235,
0.014888842,
0.022313233,
0.007197386,
-0.03263527,
-0.005381348,
-0.021779103,
0.0009631011,
0.003498544,
-0.022473471,
-0.01475531,
-0.008165495,
-0.0059188153,
-0.025838483,
-0.015863627,
-0.014822076,
0.003475176,
-0.007731515,
0.038190212,
-0.012405142,
-0.008939981,
-0.0054948507,
-0.010101712,
-0.005598338,
-0.0190684,
0.0055282335,
-0.018721215,
-0.01794673,
0.005521557,
0.011183322,
-0.02470346,
0.01154386,
-0.0038323745,
0.016544642,
0.012618794,
0.01973606,
0.18769288,
0.0042396476,
-0.0054614674,
0.017773138,
0.014514952,
-0.00986803,
0.0038857874,
-0.0036120464,
-0.008485972,
-0.014835428,
-0.00955423,
0.009193693,
-0.010996378,
0.007638043,
0.0373089,
-0.023408197,
-0.02980439,
-0.016063925,
-0.021365155,
-0.0034584843,
0.029483913,
-0.012491939,
0.0157568,
-0.019348817,
0.023234606,
-0.0037589318,
-0.024970524,
0.010916258,
0.004703672,
0.00988806,
-0.033970594,
0.015623269,
-0.009681085,
0.006643228,
0.006746715,
0.0014396441,
-0.01786661,
-0.012118048,
-0.01191775,
-0.008031962,
0.0036387527,
0.0030211664,
0.011370268,
0.0036654593,
-0.0076246895,
0.0066565806,
0.009794588,
-0.00520108,
0.0045968466,
0.0015815222,
-0.036667947,
0.057258613,
0.019696001,
0.043745153,
-0.0017592869,
-0.009560906,
0.0007673929,
0.0019195256,
-0.01504908,
0.029296968,
-0.010215214,
0.0029544001,
-0.023515023,
0.010983025,
-0.009814617,
0.014595071,
-0.010455572,
0.026893388,
0.02590525,
-0.054908447,
-0.011463741,
0.01973606,
-0.010448895,
0.0009121919,
0.00050617056,
-0.028549187,
0.04646921,
0.014501599,
0.038083386,
0.014461539,
0.018828042,
0.007684779,
-0.028709427,
0.0004940692,
-0.013566873,
-0.031860787,
0.038190212,
-0.00040518682,
-0.014007529,
-0.026145607,
0.029617446,
-0.018574331,
-0.0056717806,
0.0013369913,
0.02478358,
0.001246857,
-0.030311812,
0.023528377,
-0.012865828,
-0.008232261,
-0.02852248,
0.06687293,
0.020550607,
0.01782655,
-0.014488245,
0.0018060232,
0.018507564,
-0.00034593188,
-0.015409618,
0.005391363,
0.007377655,
-0.0050441795,
0.0030545495,
-0.020470489,
0.0033299595,
0.0068502026,
0.0246634,
-0.017452661,
0.041421693,
-0.00085126783,
-0.009193693,
-0.02988451,
-0.0048238514,
0.040300023,
-0.006569785,
0.001006499,
-0.008679594,
0.00085460616,
-0.008799773,
-0.023995738,
-0.012511969,
0.0010690923,
0.02176575,
-0.017412601,
0.008285674,
-0.011096527,
0.021498686,
-0.011750835,
-0.016437816,
0.009961503,
-0.02080432,
-0.0059755663,
0.0061024223,
0.007197386,
0.010609134,
-0.0052511543,
0.0034100788,
0.041074507,
-0.0062059094,
-0.007290859,
-0.036667947,
-0.0010482279,
-0.0058220043,
-0.0040927622,
0.022193054,
-0.018560978,
-0.003551957,
-0.0381368,
0.007411038,
0.008425883,
-0.029243555,
0.00994815,
0.006890262,
-0.020790966,
-0.005050856,
-0.016811706,
-0.16728915,
0.0034618226,
0.022553591,
-0.025624832,
0.014434832,
0.027133746,
0.0026405996,
-0.019629234,
-0.01038213,
0.0019912992,
0.00843256,
0.0100215925,
-0.051436607,
-0.030391932,
0.016397756,
0.011850984,
-0.00358534,
0.042970665,
0.016050572,
0.019549116,
0.021445272,
-0.003445131,
-0.0003392553,
-0.0016165744,
-0.00013238467,
0.0039024788,
0.026880035,
-0.015075787,
-0.0115038,
-0.044386107,
-0.028816251,
-0.00064804853,
0.021645572,
0.005611691,
-0.00711059,
-0.005738547,
-0.0025938633,
0.0002414012,
-0.0063060587,
0.01944229,
0.004843881,
0.018747922,
-0.0071439734,
0.008252291,
0.013213012,
0.037202075,
-0.009427374,
-0.012044606,
0.024222743,
0.014114355,
0.019509057,
0.0012076319,
0.03279551,
0.002066411,
0.047564175,
0.012471909,
0.03805668,
0.009013425,
-0.01307948,
-0.0056817955,
0.0014346368,
-0.010115065,
0.039311882,
-0.0044032247,
0.007531217,
-0.013713758,
0.000094880896,
0.033623412,
-0.034424603,
0.010408836,
-0.003718872,
-0.012411819,
0.020617373,
-0.012698913,
0.021405214,
0.015236026,
0.00042855495,
0.016023865,
-0.010034946,
0.00042897224,
-0.008899922,
0.009707792,
-0.01471525,
-0.008278998,
0.014902195,
-0.0038190214,
0.0061491583,
0.012652177,
-0.00092888344,
0.00038891257,
0.010922935,
-0.0069236453,
0.012625471,
0.002044712,
0.02221976,
0.019882947,
-0.022553591,
-0.033676825,
-0.023715321,
-0.000008410964,
0.0103621,
-0.019909654,
-0.0029994673,
-0.003126323,
0.03957895,
-0.0009848,
-0.029697563,
0.00908019,
0.064843245,
-0.0043631652,
0.01666482,
-0.00017974687,
0.012438525,
0.027213866,
0.008025286,
0.019375524,
-0.025184175,
0.01349343,
-0.013667022,
-0.021512039,
0.06890262,
0.0056350594,
0.0051476667,
0.0077248383,
0.00843256,
-0.010642517,
-0.11900391,
0.0014338022,
-0.0031329996,
0.022740535,
-0.013092834,
0.022112934,
-0.00026101375,
0.023862207,
-0.008265644,
0.044840116,
-0.005294552,
-0.0044699907,
0.015823567,
-0.009013425,
0.0018828042,
0.006012288,
0.016090631,
-0.018801335,
0.0043130904,
0.032742098,
-0.004406563,
-0.006286029,
0.000057011996,
-0.009273812,
0.025397826,
0.01699865,
-0.030338518,
0.0049774135,
0.032475036,
0.0010857838,
-0.011256766,
-0.028335536,
0.02586519,
0.0055783084,
-0.029296968,
-0.017773138,
0.004396548,
-0.027667874,
0.034958735,
-0.012091341,
0.0054080547,
-0.021231622,
-0.023595141,
-0.0127656795,
0.010075006,
0.0055716317,
0.0025104056,
-0.008826479,
0.008819803,
-0.013366574,
-0.03904482,
-0.032822218,
0.0024403012,
-0.011724128,
-0.0021231622,
-0.0058320193,
0.02060402,
0.026693089,
0.0006129963,
-0.006509695,
0.017065417,
0.01475531,
-0.012999361,
0.00711059,
0.0077381916,
-0.011704098,
-0.0092871655,
-0.035706513,
0.016411109,
-0.031059593,
-0.018734569,
0.008953335,
-0.0058987853,
0.014555011,
-0.022233114,
0.00336835,
-0.025104055,
-0.025170822,
0.0024453087,
-0.024770226,
-0.0025321045,
-0.03725549,
0.022486825,
-0.021298388,
0.0044800057,
0.021391861,
0.027200513,
-0.028095178,
-0.007998579,
-0.022793949,
-0.0064362525,
0.035626393,
-0.0032815542,
-0.027374104,
-0.019923005,
0.013086157,
-0.0008863201,
-0.024943817,
0.004109454,
0.03138007,
-0.011136587,
-0.020363662,
-0.07536558,
0.01558321,
-0.002480361,
-0.0017759785,
-0.0005829516,
-0.018801335,
0.0030194973,
-0.008619504,
-0.014408126,
0.006079054,
-0.015983805,
0.027040273,
-0.018587684,
-0.008906598,
-0.027801408,
0.0054147313,
0.030365225,
-0.017626252,
0.0043331203,
0.008158818,
-0.0009881384,
-0.009126927,
0.024115918,
-0.0039992896,
-0.02507735,
0.00679679,
-0.029483913,
0.024690107,
-0.03236821,
0.0043231053,
-0.016638113,
-0.039899424,
-0.02702692,
0.012011223,
0.00829235,
-0.003378365,
-0.003632076,
0.036748067,
0.022620358,
0.014060942,
-0.002765786,
-0.049647275,
0.013253072,
-0.0069236453,
0.01355352,
0.0077381916,
-0.03760267,
0.001503072,
0.0053947014,
-0.009580936,
0.035386037,
0.009146957,
0.02312778,
-0.02093785,
0.0031630443,
-0.026412671,
-0.02093785,
-0.011951133,
0.0096343495,
-0.021431921,
0.0034150863,
0.012518645,
0.013713758,
-0.025304355,
-0.003685489,
-0.0038256978,
-0.009707792,
-0.011577243,
0.002834221,
-0.016985297,
-0.04294396,
-0.004102777,
0.027881525,
0.0111032035,
-0.0045868317,
-0.0073643015,
-0.00717068,
-0.0032848925,
-0.023114426,
0.02570495,
0.009874707,
0.0051743733,
0.0005266177,
0.002996129,
0.030071454,
-0.002393565,
-0.017319128,
-0.005935507,
-0.002919348,
0.0120312525,
-0.008793096,
0.0047370554,
0.008986718,
0.012084666,
0.013586903,
0.0105824275,
-0.008038639,
0.007063854,
-0.0068368493,
0.03551957,
0.008652887,
0.020430429,
0.0007548743,
-0.0294305,
-0.014875488,
0.013046097,
-0.022313233,
-0.02491711,
0.0018060232,
-0.008893246,
0.01790667,
-0.0002668558,
-0.0032782159,
0.0012718943,
-0.009641026,
0.014915548,
-0.00074319023,
-0.010241921,
-0.010515662,
0.046709567,
-0.0023601819,
0.018013496,
0.0018343987,
0.00679679,
0.016651466,
-0.011376944,
0.030498758,
-0.019081753,
0.018347327,
-0.027093686,
0.013940763,
-0.014501599,
-0.014247887,
-0.01806691,
-0.014181121,
-0.008345763,
-0.01554315,
0.015690034,
-0.0062960437,
0.09384644,
0.009020101,
-0.03543945,
-0.006222601,
-0.0023034306,
0.037202075,
0.01158392,
0.0207242,
-0.028923078,
-0.0031663827,
0.019255346,
-0.024115918,
0.009146957,
-0.010288657,
-0.0004174968,
0.025918603,
-0.0026072164,
0.0062059094,
-0.0023468286,
-0.015142553,
0.011350238,
-0.032501742,
0.003935862,
0.0074844807,
-0.03821692,
-0.018374033,
0.01786661,
0.016785,
-0.015436323,
-0.0026322538,
0.009814617,
0.0009697777,
-0.036614534,
0.0062493077,
0.0054247463,
0.0041528516,
0.016037218,
-0.02474352,
0.020243483,
0.017265715,
0.00289598,
-0.021111444,
0.018374033,
-0.0026856665,
0.023661908,
-0.008192201,
0.0048405426,
0.0055716317,
-0.012825769
] |
The renin-angiotensin-aldosterone system plays a major role in the pathophysiology of hypertension and closely related cardio- and cerebrovascular events. Although both angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor antagonists (angiotensin receptor blockers; ARBs) are equally important in the treatment of hypertension, according to the results of recent years, there might be substantial differences in their cardiovascular protective effects, and these differences might be explained by our increasing knowledge of their non-overlapping mechanisms of action. The number of studies investigating how ACE inhibitors and ARB agents differ will certainly
|
[
-0.030625626,
0.00031333975,
0.015207751,
-0.030047784,
0.006730546,
0.025884695,
-0.000037756723,
0.0038807343,
-0.025871562,
-0.0032142461,
-0.0070457323,
0.00026491264,
-0.008982817,
0.004550506,
-0.017243331,
-0.0030944096,
0.042051136,
0.007807433,
0.0022046643,
-0.007735203,
-0.002815338,
0.014038934,
-0.008352444,
-0.005663508,
-0.008339311,
0.017453454,
0.02462395,
-0.018110093,
0.007945327,
-0.019909283,
-0.00632343,
0.019265778,
-0.006119872,
-0.001041593,
-0.015260282,
-0.009409632,
-0.015759327,
0.0039168494,
0.010873936,
-0.0017220348,
0.03637778,
-0.009403065,
-0.00828678,
0.008280213,
-0.00035581607,
-0.0022128723,
0.015128954,
-0.019397106,
-0.026515068,
0.029706331,
0.02296922,
-0.005420552,
0.0064481916,
-0.0022128723,
-0.013986403,
-0.017611047,
-0.033330977,
0.04126317,
0.017453454,
-0.01847781,
-0.004488125,
-0.0055453135,
-0.007879663,
0.013841942,
-0.013815677,
0.0010186107,
0.008227682,
0.019502167,
0.011235087,
0.019383973,
0.036298983,
0.025516978,
-0.014695573,
0.00906818,
0.021800403,
-0.038058776,
-0.028970897,
-0.013566154,
-0.0037132914,
0.014380386,
0.004471709,
-0.0047671963,
-0.0018681369,
0.00061231555,
0.018871794,
-0.0036771763,
0.012443302,
0.005952429,
-0.013658084,
-0.0027841479,
0.010348625,
0.003271702,
0.0041368236,
0.004015345,
-0.012009921,
0.01177353,
0.016547294,
0.02509673,
-0.021537747,
-0.014380386,
0.009199508,
-0.013014577,
-0.012463002,
-0.007085131,
-0.013618685,
0.02240451,
-0.021918597,
0.0037691058,
0.018635405,
-0.0054435343,
-0.014892564,
0.037585996,
-0.006920971,
-0.03225409,
0.018438412,
-0.014892564,
0.012837285,
-0.014958228,
0.006172403,
-0.0038150705,
-0.00308456,
0.023717787,
0.02089424,
-0.012745356,
0.020263867,
0.00079412234,
-0.025398782,
-0.013126207,
0.0077220704,
-0.015969452,
-0.0026955015,
0.027526291,
0.0056733578,
0.0061133057,
-0.012206912,
-0.005167746,
-0.0052826577,
-0.010020305,
-0.014025801,
-0.043311883,
-0.0014372178,
0.0113467155,
-0.04157836,
-0.026252413,
-0.013999536,
0.03790118,
0.028524382,
0.019239511,
0.008772692,
0.01311964,
-0.0047704796,
-0.028970897,
0.009573791,
-0.027920274,
-0.009160109,
0.013933872,
-0.017177667,
0.020001212,
-0.014616776,
0.0080832215,
0.018530343,
-0.0040744427,
0.004294417,
0.0026134218,
0.032385416,
0.0051578963,
-0.0024476205,
-0.0085954,
-0.0025986475,
-0.0043141157,
-0.0014396802,
0.018937457,
-0.024308762,
0.0018073978,
0.026094818,
0.008056956,
0.02155088,
0.0096854195,
0.0016957693,
-0.025451314,
-0.012357939,
-0.013001445,
0.038584087,
0.0011187481,
0.006694431,
0.02069725,
0.030362971,
-0.015417875,
0.020959904,
-0.02883957,
-0.008982817,
0.037192013,
-0.018845528,
-0.04058027,
-0.6383578,
-0.02287729,
0.0070129004,
-0.0046424353,
0.016468497,
0.0054435343,
0.020001212,
0.010933033,
-0.00042106953,
0.033803757,
-0.0017794907,
0.0016309262,
0.022575237,
-0.0058506504,
-0.009304569,
-0.018005032,
0.0031288832,
-0.014866299,
0.018215155,
-0.0042681512,
-0.0051578963,
0.025188658,
-0.002335992,
-0.01342826,
0.009626322,
0.007984726,
-0.0032651357,
-0.007446282,
-0.024177434,
0.030100316,
0.0095934905,
0.02883957,
0.00090534054,
0.020395195,
0.042024873,
0.0050922325,
0.008089788,
0.02002748,
0.0035064502,
0.047199186,
-0.009632889,
-0.021196295,
0.024046106,
-0.019370839,
0.012686258,
0.015076423,
0.020920508,
0.0022309297,
-0.005968845,
-0.013973271,
-0.016928144,
-0.0037855217,
-0.021353887,
-0.0018845529,
0.009698553,
0.011077493,
0.009652588,
-0.019003121,
-0.0065893685,
0.0068027764,
-0.022916688,
0.024151169,
-0.022483306,
-0.02320561,
0.010690077,
0.019725425,
-0.016258372,
0.010519351,
-0.012325107,
0.006783077,
0.012843852,
0.018070696,
-0.005230127,
-0.016310904,
0.021721605,
0.000020750807,
0.024085505,
0.006326713,
-0.009370233,
0.0130999405,
0.0056044105,
0.01851721,
-0.01824142,
0.013224702,
0.024164302,
0.0070785643,
0.0033685563,
-0.011294184,
0.014117731,
-0.015089556,
0.012469567,
0.0042747175,
-0.036876824,
-0.03325218,
-0.010171332,
0.036456577,
-0.013139339,
0.015247149,
0.01055875,
-0.01747972,
-0.02491287,
0.0052957907,
-0.010355191,
0.004271434,
-0.013461092,
0.012528665,
-0.02553011,
-0.0024328462,
0.05140167,
-0.0538969,
0.002352408,
-0.005863783,
-0.01629777,
0.0030385952,
0.021616545,
-0.03078322,
-0.00023249112,
-0.008148885,
0.031860106,
-0.02202366,
0.01606138,
-0.005492782,
-0.0026577448,
-0.004232036,
0.010026872,
-0.0062643327,
0.011747265,
-0.016415967,
-0.02320561,
-0.022483306,
0.018110093,
-0.02335007,
0.017138269,
0.0040383274,
0.019489035,
-0.0028678693,
0.02936488,
-0.0068421746,
-0.0009110861,
-0.030389236,
0.0005207965,
-0.021051835,
-0.0058998982,
0.015969452,
-0.009606623,
-0.012935781,
0.0071704937,
0.0058834823,
-0.0054107024,
0.0034440695,
-0.005118498,
-0.020171938,
-0.014235926,
0.023153078,
0.010617847,
-0.009737951,
-0.015089556,
-0.0062347837,
-0.023284405,
-0.009501561,
0.009586924,
-0.010276395,
-0.03154492,
0.0043436647,
-0.0041959207,
-0.03314712,
0.0035983797,
0.019318309,
-0.010946166,
-0.04191981,
0.011097193,
-0.004639152,
-0.010690077,
0.016678622,
-0.00044815586,
0.027788946,
-0.031387325,
0.0057390216,
0.0076761055,
0.0017811323,
0.0042057703,
-0.0005068429,
-0.00655982,
-0.006750245,
0.013789412,
0.0018205306,
0.0031485823,
-0.0014093106,
-0.015417875,
0.03685056,
-0.0033521403,
0.044703957,
-0.03490691,
0.0045308066,
-0.015916921,
-0.011070928,
0.0012172438,
0.006861874,
0.008615099,
0.03372496,
0.044362508,
-0.0052662417,
0.022141855,
-0.014931963,
0.009698553,
-0.0067765107,
0.016586691,
-0.0002821494,
0.035117034,
0.014643041,
-0.00975765,
-0.0018566457,
0.000679621,
-0.02013254,
-0.0005712756,
0.017125135,
0.010873936,
-0.0018467961,
-0.00045595344,
-0.013933872,
-0.02349453,
-0.014117731,
0.011169423,
-0.016127044,
-0.02387538,
0.00944903,
0.028314257,
0.025924094,
-0.016875613,
-0.008306479,
-0.007682672,
-0.00812262,
0.028261727,
-0.02396731,
-0.01319187,
0.018543474,
0.015339078,
-0.008418107,
0.016901879,
0.00671413,
0.006441625,
-0.010959298,
0.0006299627,
0.0050889496,
0.015128954,
0.023665257,
0.034276538,
0.035169564,
-0.004146673,
0.031203467,
-0.001611227,
0.008089788,
-0.011635637,
0.010191032,
0.008010991,
-0.00041101474,
0.025398782,
0.02226005,
0.036692966,
0.023704655,
0.03220156,
0.0140651995,
0.0030254624,
-0.021091232,
-0.0022900272,
0.012843852,
0.016560426,
-0.020920508,
0.0065532536,
-0.00016672465,
-0.015273415,
-0.003271702,
-0.002083186,
-0.021590278,
0.011090627,
0.018267687,
0.004928073,
-0.0077286367,
0.030967077,
0.00961319,
0.008496904,
-0.030074049,
0.022667166,
0.0010678585,
-0.0033849722,
-0.018057562,
0.0016719662,
-0.0039201328,
-0.0039792303,
0.039398316,
0.0017909819,
-0.0029844225,
0.014432917,
0.01600885,
-0.00460632,
-0.0087792585,
0.023218742,
0.013855075,
0.010092536,
-0.021485217,
-0.00011039737,
0.0015242224,
-0.0074856803,
-0.024269363,
0.030809484,
0.0045078243,
0.017768642,
-0.009002516,
-0.013658084,
0.004110558,
0.019357707,
-0.010972432,
0.009980908,
-0.006425209,
0.010473386,
0.016849346,
-0.006730546,
-0.0029680065,
0.01738779,
0.0041959207,
-0.006888139,
-0.025031066,
0.008280213,
-0.01629777,
0.04874885,
-0.018871794,
-0.016402833,
0.024597684,
-0.018385882,
-0.0012073943,
-0.012220045,
-0.019961815,
0.020959904,
0.0056536584,
-0.018648537,
-0.0093768,
0.012929215,
0.0051480466,
0.015234016,
0.024177434,
-0.0008056135,
-0.027211105,
0.019725425,
-0.007052299,
0.01084767,
0.014800635,
0.035931267,
0.03472305,
0.015023892,
0.00445201,
0.005725889,
0.006697714,
0.01704634,
-0.021826668,
0.014012668,
0.010933033,
-0.02093364,
0.0144591825,
-0.0116487695,
-0.0073215207,
-0.00040301197,
0.009954642,
0.016429098,
0.00045882625,
0.0421562,
0.02089424,
0.004793462,
0.004671984,
-0.0065237046,
-0.037717324,
0.022194386,
0.008503471,
0.0171514,
-0.0049740374,
-0.02396731,
-0.005341755,
-0.025687704,
-0.008240815,
0.029233553,
-0.015312813,
-0.008890887,
-0.009698553,
-0.012594329,
0.00039295718,
-0.029916456,
-0.007682672,
0.03921446,
-0.025280587,
0.009672287,
0.0061133057,
-0.013920739,
-0.010880502,
-0.00522356,
0.025411915,
0.029522473,
-0.015286547,
-0.026370607,
0.0413945,
0.0336199,
0.018096961,
0.011451778,
-0.020066876,
-0.0007206609,
0.024335029,
-0.009192941,
-0.014130863,
-0.009540959,
-0.03950338,
-0.00554203,
-0.0059064645,
-0.009258605,
-0.005985261,
0.01956783,
0.012673126,
0.010762307,
-0.023008619,
0.053844366,
-0.025661437,
0.00999404,
0.006231501,
0.01139268,
0.017978765,
-0.008693895,
-0.01709887,
-0.014892564,
-0.018044429,
-0.0044290274,
-0.031098405,
0.0073477863,
-0.011675035,
0.0005343397,
0.0022571953,
-0.0014437842,
-0.012062452,
0.011353282,
-0.027683884,
0.0009890619,
0.0042451685,
0.015483539,
0.00710483,
-0.004415895,
0.016205842,
0.023284405,
0.000111936366,
-0.009691986,
0.011970522,
0.022010528,
0.01420966,
-0.029706331,
0.019449636,
0.018451545,
-0.01006627,
-0.018083828,
0.0036476275,
-0.014905697,
0.054317147,
-0.007262423,
-0.032910727,
-0.03808504,
0.015785594,
-0.011661902,
-0.0068027764,
-0.002168549,
-0.0029121924,
-0.026515068,
-0.015943186,
-0.0034112376,
0.012344806,
0.020631585,
-0.039319523,
-0.002751316,
0.013139339,
-0.015234016,
-0.0022818192,
-0.022338847,
-0.004176222,
-0.009803615,
0.007597309,
-0.01430159,
-0.03143986,
-0.013855075,
-0.023914779,
0.0147612365,
0.041525826,
0.0038150705,
-0.0021504916,
0.011130025,
0.01600885,
0.010433988,
0.0001470255,
-0.0020700532,
0.005473083,
-0.040475205,
0.040002424,
0.016468497,
0.019475901,
0.014748104,
-0.013815677,
0.019791089,
0.0011688168,
0.0012689541,
-0.018924326,
-0.01231854,
-0.010361758,
0.001639955,
0.01633717,
-0.009219206,
0.0023950895,
-0.03524836,
-0.012141248,
0.020237602,
-0.01600885,
-0.00280713,
-0.018372748,
0.0011138233,
-0.001070321,
0.020500258,
-0.000008586319,
0.009934942,
-0.002391806,
-0.014406651,
-0.010427422,
0.016048249,
0.009580358,
0.0018123226,
0.011510875,
0.018162625,
-0.033856288,
-0.012791321,
0.010795139,
-0.02723737,
0.00050438056,
-0.0072821225,
-0.005016719,
0.015470406,
0.003719858,
-0.017505987,
-0.02140642,
0.014879432,
0.019108184,
-0.012791321,
0.022601502,
-0.005909748,
0.00018098603,
0.010519351,
-0.022745961,
0.02491287,
0.0061067394,
0.020053744,
0.03614139,
-0.0058670663,
0.0040547433,
-0.0083852755,
0.0020930357,
0.0035918134,
0.030074049,
0.008700462,
-0.00068700814,
-0.018044429,
-0.011635637,
0.021957995,
-0.02718484,
-0.035642345,
0.039188195,
-0.0095934905,
0.004159806,
0.0032093213,
0.011327016,
-0.0035655478,
-0.00022797672,
-0.009665721,
-0.014222792,
0.0072821225,
-0.023809716,
-0.0249654,
0.016757417,
0.0022457042,
0.010617847,
0.0074988133,
-0.02841932,
-0.019633494,
0.016205842,
0.00045800544,
0.00010536998,
-0.0005335189,
0.018727334,
-0.009396499,
-0.0027611654,
-0.00061108434,
0.009626322,
0.0006746962,
-0.00522356,
-0.0050889496,
0.04021255,
-0.013126207,
-0.022851024,
0.03643031,
-0.021472083,
0.009304569,
-0.0013871491,
-0.009468729,
-0.03803251,
-0.014262191,
-0.00089713256,
0.029680066,
0.02960127,
-0.038242634,
0.008700462,
-0.021537747,
-0.017217064,
-0.016376568,
-0.0063825273,
-0.00070014095,
-0.029837659,
-0.03482811,
-0.0041565225,
-0.018792998,
0.014249058,
-0.0015521295,
-0.012351372,
0.01053905,
-0.007511946,
-0.014905697,
0.0028416037,
-0.0029121924,
0.01653416,
-0.019869884,
0.006270899,
-0.0390306,
-0.036745496,
0.0117997965,
-0.0058178185,
-0.020631585,
-0.01571993,
-0.005272808,
0.009383366,
0.011340149,
-0.0021390005,
0.019003121,
-0.01866167,
-0.0036968754,
-0.017676711,
-0.0075710434,
-0.0056044105,
0.006920971,
-0.014354121,
0.028445585,
-0.024269363,
-0.011996788,
-0.0052990736,
0.017913101,
-0.0012508966,
-0.0000983932,
-0.023034884,
-0.028261727,
0.02382285,
-0.032516744,
-0.021866066,
-0.002226005,
-0.006576236,
-0.014787502,
0.008221116,
0.012154381,
0.003486751,
0.01766358,
-0.0036213621,
-0.008037257,
-0.016455363,
-0.025464445,
0.02008001,
0.0026150635,
-0.010374891,
-0.03130853,
-0.009206073,
-0.005065967,
0.033567365,
0.011110325,
0.0035786806,
-0.006070624,
-0.0069932016,
-0.051795654,
0.00065048266,
-0.019541565,
0.033383507,
0.0031436575,
0.006238067,
0.04940549,
0.014012668,
-0.0018041147,
0.008089788,
-0.009422764,
-0.017125135,
0.00035930445,
-0.0028547365,
0.02145895,
0.00016928965,
-0.058467105,
-0.018674802,
0.036062595,
-0.03732334,
0.0013157397,
0.027158573,
0.0026413288,
0.021590278,
-0.0043305317,
0.021091232,
0.012778188,
-0.009698553,
0.015207751,
-0.029338613,
-0.005033135,
0.027500026,
0.015785594,
-0.023901647,
-0.0031321663,
-0.0070982636,
0.0070916973,
-0.008214549,
-0.024899736,
-0.027788946,
0.02155088,
-0.0022489873,
0.009107578,
0.012055885,
-0.020460859,
0.014038934,
0.0031387326,
0.002751316,
0.0012640294,
-0.015010759,
0.0019879735,
-0.006080474,
0.009540959,
-0.0009652588,
-0.01606138,
-0.009606623,
0.014314722,
-0.025543243,
0.009672287,
0.000060944272,
-0.0072821225,
-0.0024180717,
0.019265778,
-0.002014239,
0.0062347837,
0.016376568,
0.009606623,
-0.019856753,
-0.011996788,
-0.006661599,
0.01055875,
-0.0031502238,
0.011116892,
0.0073346533,
-0.012331674,
-0.001033385,
0.0010612921,
-0.015470406,
-0.012673126,
0.018674802,
0.19152835,
0.0053811534,
-0.010965865,
0.016271506,
-0.018096961,
0.006133005,
-0.0043567973,
0.0070457323,
-0.0015783951,
0.0066681653,
-0.0035327158,
0.0017679995,
-0.030730687,
-0.0013296932,
-0.0017105436,
-0.041289438,
-0.016048249,
-0.01709887,
0.021616545,
0.0060771904,
0.004911657,
0.01124822,
0.008982817,
-0.014879432,
0.017282728,
-0.0008659422,
-0.0093505345,
-0.0034769014,
0.037769854,
0.0019666327,
-0.012292275,
-0.0025658153,
-0.0027808647,
0.02008001,
-0.0069472366,
-0.026370607,
-0.013789412,
0.010873936,
0.0048755417,
-0.005903181,
-0.030678157,
0.008188284,
0.0008265439,
-0.008181717,
0.013763146,
0.01420966,
-0.0024164303,
-0.03485438,
0.0017532251,
-0.002644612,
-0.046542548,
0.011359848,
0.010624413,
0.013763146,
0.0077089374,
-0.0067633777,
0.02700098,
-0.0017663579,
-0.009048481,
0.008746427,
-0.0010424139,
-0.009678854,
-0.014288456,
0.010519351,
-0.015601734,
0.033856288,
-0.02491287,
0.013342897,
0.02723737,
0.000025354972,
-0.00323887,
-0.036036327,
-0.016310904,
-0.006595935,
-0.0050397017,
-0.008096354,
0.02145895,
0.040133752,
0.015641132,
0.014052067,
0.008858055,
0.010814838,
-0.01842528,
0.019121317,
-0.023901647,
-0.023560194,
0.0017236765,
0.008877754,
-0.009206073,
0.0030057633,
0.0038282033,
-0.041341968,
-0.031177202,
-0.021944864,
0.030940812,
-0.007682672,
-0.025871562,
-0.02249644,
0.0060574915,
-0.0006812626,
-0.007518512,
0.09728758,
0.0018779865,
0.005190728,
-0.017991899,
-0.009980908,
0.014038934,
0.016415967,
-0.00261178,
0.022509573,
0.0023540496,
-0.01577246,
-0.004028478,
-0.018530343,
-0.0054336847,
0.02273283,
0.02055279,
-0.023048015,
0.009862713,
-0.03425027,
-0.02202366,
-0.008221116,
-0.015930053,
0.03306832,
0.0029121924,
0.010499652,
-0.01895059,
0.009087878,
-0.021800403,
-0.021655941,
0.001058009,
-0.03230662,
0.0071639274,
0.0013920739,
0.009324268,
0.011031529,
0.021432685,
-0.017519118,
-0.012141248,
0.021485217,
0.0028350372,
0.010795139,
0.00883179,
0.013034277,
0.020736648,
-0.0040514604,
0.011878593,
-0.00070096174,
-0.008752993,
0.011819496,
-0.01847781,
-0.006710847,
-0.007439716,
-0.010657245,
0.006609068,
-0.01070321,
0.004543939,
-0.023914779,
0.03296326,
0.011366415,
-0.032437947,
0.014222792,
0.006730546,
-0.021038702,
0.004839427,
-0.004383063,
-0.16452737,
0.027447496,
0.04026508,
-0.0147612365,
0.010309227,
0.010348625,
0.017558517,
0.01600885,
-0.012712524,
0.0069800685,
0.02273283,
-0.02543818,
0.0071639274,
-0.02202366,
0.035064504,
-0.0015669039,
0.005663508,
0.018438412,
0.018582873,
0.0024082223,
0.039345786,
-0.018569741,
0.010814838,
-0.026777724,
0.017597916,
0.01288325,
0.005502632,
-0.010755741,
0.0005556804,
0.003992363,
-0.011963956,
0.011826062,
0.038689148,
-0.0011302392,
0.010250129,
0.011707867,
-0.0061953855,
-0.0034046713,
-0.009363667,
0.015641132,
0.03262181,
0.018963724,
-0.006888139,
0.001159788,
-0.023573328,
0.038242634,
0.004455293,
-0.010644112,
0.024032975,
-0.004862409,
-0.00061847153,
0.0014954945,
0.0055814283,
0.0033143836,
0.027526291,
0.011753831,
-0.026515068,
0.020263867,
-0.015995717,
-0.016218973,
-0.008102921,
0.012778188,
0.018254554,
0.006054208,
0.015115822,
-0.026462536,
0.017637314,
-0.0041565225,
-0.011911425,
0.031361062,
-0.03461799,
-0.031466123,
-0.00041470834,
-0.039372053,
0.023363203,
0.023100547,
-0.026803989,
0.002726692,
0.00788623,
0.01319187,
0.0074922466,
0.0009127277,
-0.022076191,
-0.03690309,
0.013539889,
0.0041236905,
0.02193173,
0.0034801848,
0.026738325,
-0.017295862,
0.025254322,
-0.037244543,
0.011123459,
-0.029968986,
-0.02841932,
0.01122852,
0.01295548,
-0.012187213,
-0.0007255857,
-0.006848741,
0.02287729,
-0.012561497,
-0.00046949662,
0.0008815374,
0.0131590385,
-0.008693895,
-0.013566154,
-0.0014470674,
0.026436271,
-0.019449636,
-0.0029138338,
0.015627999,
0.013763146,
0.023560194,
-0.015982585,
0.025595773,
-0.005656942,
-0.02008001,
-0.025044197,
-0.05247856,
0.05925507,
0.01704634,
0.0033751226,
0.027867744,
-0.004261585,
-0.040659063,
-0.12733537,
-0.03383002,
0.018884927,
0.0073674857,
-0.016521027,
0.018740466,
-0.004662134,
0.028865835,
-0.0025608907,
0.023192476,
-0.035773672,
-0.006149421,
-0.0037658226,
-0.019305175,
0.021826668,
-0.008109487,
-0.0047310814,
-0.032359153,
-0.020907374,
0.03367243,
-0.014117731,
-0.015168352,
0.00912071,
-0.027263636,
0.0038971503,
0.016718019,
-0.007019467,
0.0017794907,
-0.016179577,
0.0059885443,
0.018215155,
0.0019354423,
-0.0047310814,
-0.0020076726,
-0.0014995985,
-0.02694845,
-0.0046490016,
-0.018372748,
0.038479023,
-0.014012668,
0.010486519,
0.0010448762,
0.033462305,
-0.015785594,
-0.014012668,
-0.0069144047,
-0.03477558,
-0.01264686,
-0.0026265546,
-0.021248827,
-0.007117963,
-0.033882555,
-0.020500258,
0.007859965,
0.045675784,
0.0020322965,
0.0019223096,
0.025241189,
-0.021051835,
-0.015404742,
0.0058670663,
0.0015734703,
-0.005863783,
-0.017361525,
0.008707028,
-0.028077869,
-0.0024115054,
-0.022286315,
0.009698553,
-0.023599593,
-0.0016974108,
0.0043469477,
-0.024282496,
0.020066876,
-0.0257271,
0.018228289,
-0.024597684,
-0.015588601,
0.0077286367,
-0.011182556,
-0.031623717,
-0.011517442,
0.008162018,
-0.0072821225,
0.008162018,
0.0027168423,
-0.0041007083,
-0.01766358,
-0.0059885443,
-0.036745496,
-0.0029253252,
0.029863926,
-0.00026511785,
0.011701301,
0.017558517,
0.015352211,
-0.002380315,
-0.027211105,
0.0072689895,
0.00944903,
-0.012962047,
-0.0036673266,
-0.030914547,
0.009015649,
0.0038150705,
0.008844922,
0.0005166925,
0.0037001588,
0.023100547,
-0.01006627,
0.0016842781,
-0.018031297,
-0.036535375,
-0.009829881,
-0.003051728,
0.007564477,
-0.02623928,
-0.010328926,
0.032464214,
-0.0035655478,
0.0062840316,
-0.0059754117,
-0.014288456,
0.026488803,
0.011024962,
0.01084767,
-0.0046654176,
0.009146976,
-0.022181254,
-0.0070982636,
-0.017729243,
-0.004823011,
0.005065967,
-0.028760772,
0.006031226,
-0.012699391,
-0.017611047,
0.002234213,
-0.00624135,
0.052846275,
0.02060532,
0.020211337,
-0.025753368,
-0.028997162,
0.008798958,
-0.027500026,
0.021918597,
-0.0021537747,
-0.048564993,
0.029916456,
-0.011720999,
-0.027762681,
0.0096854195,
0.013828809,
-0.016113913,
-0.037244543,
-0.044966612,
-0.006192102,
0.010473386,
-0.017256463,
-0.03059936,
-0.025543243,
0.032464214,
0.006375961,
-0.0043797796,
-0.0272899,
0.012916082,
-0.0032158876,
-0.0022539122,
0.0041959207,
0.03537969,
0.005302357,
-0.011944257,
-0.014971361,
-0.02600289,
0.006953803,
0.014695573,
0.009192941,
0.000017518914,
0.004438877,
-0.008956551,
-0.0095343925,
0.013868208,
-0.020447727,
-0.013434826,
-0.0003921364,
-0.018359616,
-0.013067109,
-0.006694431,
0.009127277,
-0.010342059,
0.0009192941,
0.010493086,
-0.0010268186,
-0.02718484,
0.025976624,
0.025162393,
0.03425027,
-0.012581197,
-0.021025568,
-0.0028678693,
0.03154492,
0.0095934905,
0.0003720268,
-0.025700836,
-0.020592187,
-0.010250129,
0.00648759,
0.0030090464,
-0.015181486,
-0.020093143,
-0.00022428314,
0.0093571,
0.014143996,
0.012653426,
-0.0046358686,
0.0031518654,
0.02638374,
-0.012640294,
-0.023612725,
-0.010827971,
0.018871794,
0.0029647234,
0.011596238,
-0.01610078,
0.019305175,
-0.007748336,
0.010696643,
0.029102225,
-0.015076423,
0.020145673,
0.012587762,
0.0075053796,
-0.012489267,
-0.032464214,
-0.0041959207,
-0.022601502,
-0.036351513,
0.010709777,
0.02936488,
-0.0061297216,
0.062249344,
0.0037132914,
-0.004130257,
0.0074594147,
-0.0012041111,
0.03566861,
-0.012069018,
0.027132308,
-0.0069144047,
-0.027683884,
-0.0031748477,
0.0014265474,
0.011517442,
-0.038216367,
-0.013658084,
0.021524614,
-0.023901647,
0.00025998786,
0.0003326285,
-0.024413824,
0.023441998,
-0.0011244937,
0.018202024,
0.0033784057,
-0.034171473,
-0.014485449,
0.035064504,
-0.010525918,
-0.006037792,
-0.031387325,
-0.03212276,
0.020434594,
-0.042129934,
-0.0015562335,
0.041026782,
0.003759256,
-0.005847367,
-0.0049313563,
-0.0011105401,
0.0040514604,
0.015614866,
0.024991667,
-0.015273415,
-0.041184373,
0.0015701872,
-0.013631818,
-0.031150937,
-0.02491287,
-0.011898292
] |
Cells such as fibroblasts and endothelial cells migrate through the coordinated responses of discrete integrin-containing focal adhesions and complexes. In contrast, little is known about the organization of integrins on the highly motile T lymphocyte. We have investigated the distribution, activity, and cytoskeletal linkage of the integrin lymphocyte function associated antigen-1 (LFA-1) on human T lymphocytes migrating on endothelial cells and on ligand intercellular adhesion molecule-1 (ICAM-1). The pattern of total LFA-1 varies from low expression in the lamellipodia to high expression
|
[
-0.022203786,
0.015387183,
-0.003936488,
0.00018789672,
-0.012982106,
0.0055908095,
-0.03887988,
0.0061223186,
-0.029551897,
-0.005325055,
0.019479802,
-0.0048732725,
0.0015762561,
0.009985724,
-0.025897773,
0.002061258,
0.029232992,
-0.007354755,
-0.038135767,
-0.005703755,
-0.022974474,
0.004999506,
0.0074145496,
-0.021273645,
-0.016436914,
0.008643664,
0.012417377,
-0.03816234,
-0.009839559,
-0.017672671,
0.016264174,
-0.0015480197,
-0.026628597,
0.0073879743,
0.00014678782,
-0.013845808,
0.010085382,
0.0009459198,
0.03887988,
0.0011809464,
0.012158267,
0.017486643,
0.000006342163,
-0.0007532478,
0.0032289168,
0.00093927595,
0.0018038084,
-0.0137129305,
-0.026469145,
0.03986317,
0.012829297,
-0.0019184151,
-0.0065010185,
-0.004212208,
-0.033591364,
-0.028116822,
0.01065011,
0.0019931586,
0.005192178,
-0.03672727,
-0.020436518,
-0.005707077,
-0.018257331,
-0.00077400985,
-0.010178396,
0.02579147,
0.0043052225,
0.012902379,
0.015387183,
-0.006510984,
0.019639255,
0.021831729,
-0.00799921,
0.0007511716,
0.042627018,
-0.016131297,
-0.016157871,
-0.009680106,
-0.012450596,
0.006491053,
-0.00085373624,
-0.03319273,
0.005288514,
0.04727772,
-0.0036441581,
0.0011576929,
0.02054282,
0.010450794,
0.006278449,
0.010902577,
0.0014907165,
0.0037604256,
0.009560517,
0.030109981,
0.0003243035,
0.0014375655,
-0.012204774,
0.019001445,
0.01458992,
-0.022947898,
0.0053449864,
-0.0019914976,
0.0016368814,
-0.017818836,
-0.021752004,
-0.038374946,
0.021805154,
0.0073215356,
0.01949309,
-0.002640935,
-0.023040911,
0.033405337,
-0.0046340935,
-0.035983153,
0.00088446407,
-0.01354019,
0.023612285,
-0.010351136,
-0.009088803,
-0.024675302,
0.006823246,
0.038747,
0.013447176,
-0.02334653,
0.03922536,
0.026097089,
0.011267989,
0.0057768375,
-0.026216678,
0.004451387,
0.0008994128,
0.01187258,
-0.01216491,
0.0032438654,
-0.012742926,
-0.028488878,
-0.008444348,
0.004308544,
-0.014961977,
-0.022084195,
0.009241612,
0.02310735,
0.0038036108,
0.00041524135,
0.0016202717,
0.03468096,
0.0312793,
-0.0037205624,
0.001777233,
0.0052154316,
-0.013686355,
-0.01009867,
0.0021476282,
0.0024266704,
-0.022854883,
0.015068278,
-0.021725427,
0.026229966,
-0.019147608,
0.0031026835,
-0.0049629644,
0.0052021435,
0.021313509,
0.025605442,
0.04581607,
0.02515366,
0.011832718,
-0.0065442035,
-0.0012158267,
-0.01605157,
0.011500524,
0.020356791,
-0.017460069,
0.013360806,
-0.0011552015,
0.011473949,
0.017406918,
-0.002685781,
-0.02878121,
-0.048872247,
0.014696222,
0.022283511,
0.02124707,
-0.027983945,
-0.0122778565,
-0.00758729,
0.028807783,
-0.014523481,
-0.017247465,
-0.02947217,
-0.019705694,
0.022655569,
-0.0026043938,
-0.041723453,
-0.63398385,
-0.015599787,
0.03869385,
-0.0038202205,
0.003976351,
0.027160106,
0.017088013,
-0.017486643,
0.005242007,
-0.0016377119,
-0.02468859,
0.034813836,
0.00010682084,
-0.021100905,
-0.03553137,
-0.019293774,
0.00018914243,
-0.019931585,
0.017181026,
0.0018320448,
-0.0107697,
-0.015599787,
0.010776344,
0.019293774,
0.0021276968,
-0.015825678,
0.04230811,
0.0024167045,
-0.00061621814,
0.033485062,
-0.021911455,
0.020449806,
-0.012410734,
-0.008716746,
0.04746375,
0.0005875665,
-0.014005261,
0.01639705,
0.025990786,
0.038906455,
-0.011055386,
-0.016250886,
-0.004288613,
0.0127628585,
-0.0050194375,
0.01365978,
-0.0023685368,
-0.002355249,
0.010258122,
-0.010949084,
-0.009985724,
0.013068476,
-0.043344554,
0.0030927176,
0.00813873,
0.0056140632,
0.025100509,
0.0018071304,
-0.0014109901,
0.00918846,
0.014908825,
0.0051058074,
-0.028063672,
-0.015785815,
-0.003783679,
0.004451387,
0.005624029,
0.009607024,
0.014829099,
-0.0004127499,
0.015373896,
0.038481247,
0.0073879743,
0.007135507,
0.008590513,
0.019772133,
0.009613668,
0.028356,
-0.022961186,
-0.0015438673,
-0.013061832,
-0.0047237854,
0.0011659977,
0.015054991,
0.009533942,
0.017699247,
-0.035797127,
0.024901193,
-0.007859688,
0.0085506495,
0.0072152335,
0.02281502,
-0.0045145038,
-0.05596789,
-0.028754633,
0.029950527,
-0.0029066894,
0.02339968,
-0.0030478714,
-0.025047358,
0.00011107706,
-0.006225298,
0.01751322,
-0.012065252,
0.02159255,
0.002057936,
-0.044620175,
0.019745557,
0.02708038,
-0.04400894,
-0.010789631,
-0.024994208,
-0.009746545,
-0.014736085,
-0.010278054,
-0.013407312,
-0.0019300418,
0.017460069,
0.027093668,
-0.035451647,
0.011726416,
-0.013347518,
0.02095474,
0.006202045,
0.039836593,
0.0008250846,
-0.015453622,
-0.021579262,
-0.010484014,
-0.005760228,
0.00016547368,
0.0004957982,
0.020861726,
-0.023200365,
0.018828703,
0.017194314,
0.027558738,
0.010590316,
-0.011560319,
-0.037099324,
-0.03263465,
-0.0006988512,
0.008789829,
-0.03675384,
-0.023412969,
-0.00452447,
-0.004982896,
0.00997908,
0.00015550789,
0.0070225615,
-0.010557096,
0.0025578868,
-0.009620312,
0.013599984,
0.025485853,
-0.013035256,
-0.01517458,
-0.025366263,
0.014111562,
-0.019851858,
-0.01605157,
-0.0013296028,
-0.0059329686,
0.012510391,
0.010663398,
0.017008286,
-0.0071421512,
0.005079232,
-0.0036175826,
-0.039756868,
0.0022771836,
-0.017752398,
-0.01312827,
0.029658198,
0.0011676587,
0.006567457,
-0.0070823566,
-0.003220612,
0.0012980445,
-0.021087617,
-0.00843106,
-0.014908825,
0.020742135,
-0.004331798,
0.023878038,
0.0072418093,
0.029339293,
0.014643071,
-0.01873569,
0.027146818,
-0.00469721,
0.0009550551,
-0.027558738,
-0.009347913,
-0.0008072292,
0.00021966267,
0.0132345725,
0.017420204,
-0.004411524,
0.017871987,
0.0074145496,
-0.020502957,
0.0012316059,
-0.008949282,
0.014403892,
-0.008537362,
-0.022243649,
-0.024183657,
0.034016572,
-0.00016651179,
0.01896158,
0.009494078,
0.00010920848,
0.00307943,
0.017074725,
-0.005766872,
-0.0030893956,
0.0019433295,
-0.0042487495,
-0.004504538,
-0.019466514,
0.010776344,
0.033538215,
-0.022549266,
-0.0014118206,
-0.002011429,
0.010889289,
0.023492694,
-0.008404485,
-0.007308248,
-0.020037886,
0.010689973,
0.03981002,
0.029153265,
0.0029050284,
-0.0023170467,
0.012769502,
-0.004707176,
0.027851067,
-0.00012021237,
0.027532162,
0.026057225,
-0.0065209502,
0.00018633956,
0.0025263284,
-0.020861726,
0.0002732288,
0.011487237,
0.0011535404,
0.014563344,
-0.00005564234,
0.019147608,
-0.007813181,
-0.006949479,
-0.006863109,
-0.002501414,
0.0009700038,
0.017553082,
0.032501772,
0.0138059445,
0.002647579,
0.0023054199,
0.0017855378,
-0.0012332668,
-0.00066936907,
0.002069563,
-0.006394717,
-0.0025661916,
-0.014430467,
-0.0151480045,
-0.0138059445,
0.0050227595,
0.042228386,
-0.04674621,
0.009759833,
0.014111562,
0.021845017,
-0.00090107374,
0.018350346,
0.00070466456,
0.000517806,
-0.03728535,
0.018363634,
0.021021178,
-0.012224705,
-0.024662014,
-0.022416389,
0.011294565,
-0.017420204,
-0.011055386,
0.011859293,
0.001629407,
0.011254702,
-0.005810057,
-0.0006236925,
0.004717142,
0.025352975,
-0.0064478675,
0.02363886,
-0.010025587,
0.0033302356,
-0.00039427166,
0.0049729305,
-0.019918296,
0.044965655,
0.0077068796,
0.0048201215,
-0.01470951,
-0.0038467958,
-0.016994998,
-0.012311076,
-0.009035652,
0.00041607182,
-0.009793052,
0.002695747,
0.0009708343,
0.011008878,
-0.000578016,
0.03927851,
-0.015294169,
-0.022163922,
-0.03316616,
-0.0037770353,
-0.021526111,
0.02019734,
0.010344492,
-0.003973029,
0.01140751,
-0.006663793,
-0.011640046,
-0.0033235918,
-0.008683527,
0.01298875,
-0.005869852,
-0.012596762,
-0.012410734,
0.0107697,
-0.01321464,
0.0215394,
0.04079331,
-0.013553478,
-0.014523481,
0.0047337515,
0.0066671153,
0.013606628,
-0.010696617,
0.04020865,
0.022575842,
0.026402706,
0.01345382,
-0.005175568,
0.008995788,
0.003363455,
-0.014802524,
0.019360213,
0.029100114,
0.0037272063,
0.004906492,
-0.031438753,
-0.03531877,
-0.0010920848,
0.001974888,
0.010909221,
-0.01056374,
0.017101299,
0.012038677,
0.009440928,
0.000041550087,
0.0042520715,
-0.0048666284,
0.0046108398,
-0.005172246,
0.01658308,
-0.01856295,
0.021605838,
-0.032182865,
-0.0018287229,
-0.02642928,
-0.0018403496,
0.020051174,
-0.0067368755,
-0.020343505,
-0.0017905207,
-0.029923953,
-0.011799498,
-0.018549662,
-0.0044447435,
-0.01949309,
-0.007042493,
-0.017473357,
-0.02264228,
0.003747138,
-0.011467305,
-0.021393234,
-0.0037637476,
-0.030508613,
-0.030296009,
-0.0074145496,
0.023718586,
0.013925534,
0.024117218,
0.0016676093,
-0.001107864,
0.024369685,
-0.00526526,
-0.009301406,
-0.018403497,
-0.017234176,
-0.018974869,
0.0036109388,
0.010105314,
-0.012151623,
0.011839361,
-0.009905998,
-0.0020778677,
-0.0037670694,
0.003600973,
-0.014829099,
-0.013307655,
0.014271014,
0.0116134705,
-0.00054272043,
-0.006776739,
-0.009321338,
-0.008152018,
-0.04249414,
0.010849426,
-0.00078065373,
-0.017778974,
-0.0036175826,
0.010809563,
0.008005853,
-0.019240623,
-0.0040560775,
-0.011254702,
-0.020821862,
0.009454215,
-0.0005364918,
0.034388628,
0.030375736,
0.010763056,
0.0012930615,
0.027505588,
-0.019758845,
-0.013686355,
-0.01412485,
0.022389814,
0.004315188,
-0.027186682,
0.004856663,
-0.0049762526,
-0.0045776204,
-0.019625967,
-0.00918846,
-0.0049629644,
0.013181421,
0.019944873,
-0.01943994,
-0.02573832,
-0.0022954543,
0.0026758153,
0.004986218,
-0.0131415585,
-0.00033966743,
-0.007235165,
0.015958555,
-0.0045311134,
-0.029791076,
0.001729065,
-0.03215629,
-0.014829099,
0.02615024,
-0.0051058074,
0.024608864,
-0.009494078,
0.00019599391,
-0.0067003346,
0.0008886165,
-0.009666818,
-0.03284725,
-0.016038282,
-0.015400471,
0.04044783,
0.044567022,
0.024675302,
0.00182374,
0.039305083,
-0.0017041505,
-0.004551045,
0.01365978,
0.0035212466,
0.015706088,
-0.000093844545,
0.015427046,
0.024595575,
0.011852649,
0.03553137,
-0.011108536,
0.018297195,
0.019466514,
-0.01896158,
-0.012085184,
0.000984122,
-0.018257331,
-0.020330217,
0.018828703,
-0.004956321,
-0.0076537286,
-0.03391027,
0.0010430863,
-0.0040361458,
-0.0058764955,
-0.005192178,
-0.0004933067,
0.0152410185,
0.00020772449,
0.03199684,
0.0003384217,
0.0029482136,
-0.007015918,
-0.017154451,
0.001250707,
0.0016285765,
0.033299033,
-0.0021476282,
-0.004740395,
0.02351927,
-0.00095173315,
0.005315089,
-0.011633402,
-0.006388073,
-0.006099065,
-0.018283907,
-0.021898167,
-0.0038368301,
-0.021154055,
-0.03728535,
-0.029339293,
0.0024698556,
-0.0071487953,
-0.0061156745,
0.015745953,
0.0036939871,
-0.024941057,
0.03717905,
-0.012935598,
0.02637613,
-0.03600973,
0.021991182,
0.013686355,
0.00063116685,
-0.017539795,
-0.011846005,
-0.009620312,
0.0013520259,
0.03034916,
0.011400866,
-0.0040660435,
-0.01832377,
-0.017154451,
0.009301406,
0.004793546,
-0.01990501,
0.016795682,
0.01563965,
-0.00053483085,
-0.022442965,
-0.015320745,
-0.028329426,
0.008955926,
0.006481087,
0.0137129305,
-0.001508987,
0.0015189529,
-0.010371068,
0.029684775,
0.0019134321,
0.0034282326,
-0.0011518796,
-0.013174778,
0.00062120106,
-0.01065011,
-0.010204972,
-0.00021758646,
0.00799921,
0.014510194,
0.018190892,
0.0034049791,
0.020051174,
0.015679514,
-0.0028983846,
-0.007899552,
0.003600973,
0.0448062,
-0.0048699505,
0.004212208,
0.01307512,
0.0121848425,
0.010092026,
-0.011454018,
0.01593198,
0.022429677,
-0.029073538,
-0.014749372,
0.017553082,
-0.005796769,
-0.00555759,
-0.006099065,
-0.02981765,
-0.00913531,
-0.015985131,
-0.03332561,
-0.026004074,
-0.05158294,
-0.008510787,
0.021393234,
0.018350346,
0.00225393,
-0.009075515,
-0.0024216876,
-0.013447176,
0.03298013,
-0.034388628,
0.03252835,
0.020941451,
0.020981316,
-0.031172998,
-0.0023785024,
-0.010590316,
-0.022496115,
-0.005570878,
-0.011759635,
-0.027292984,
0.00225393,
0.0038999468,
0.0037072748,
0.0055011176,
-0.033750817,
0.0077533866,
0.005727009,
0.032076564,
0.0106567545,
-0.0027738123,
0.004185633,
-0.038587548,
-0.002880114,
0.030136555,
-0.024622152,
0.014071699,
0.03941139,
-0.0118991565,
-0.00163439,
0.006922904,
-0.021924743,
-0.03468096,
-0.004836731,
-0.017074725,
-0.0040593995,
0.00750092,
-0.010743124,
-0.015918693,
0.004501216,
0.0014350741,
-0.011799498,
-0.0011219821,
0.025525717,
-0.0045776204,
0.04190948,
-0.018709114,
-0.0016966761,
0.015573212,
-0.0153340325,
0.0013412295,
0.013154846,
-0.014244439,
0.024781603,
0.00022381509,
-0.005325055,
-0.015347321,
0.00024063236,
-0.069308765,
-0.022947898,
0.013380737,
-0.006720266,
-0.008331402,
0.01149388,
-0.0130419005,
0.01470951,
-0.0018087913,
0.012304432,
0.0053483085,
-0.010297986,
0.026668461,
-0.018164318,
0.008769898,
0.028488878,
-0.030375736,
-0.04544401,
0.028063672,
0.005218753,
-0.00024436953,
0.01639705,
-0.020436518,
0.029445594,
-0.0056838235,
0.0027040518,
-0.008424416,
0.0012166571,
0.021632414,
-0.015666226,
0.009148598,
0.006949479,
-0.011958951,
0.0047702924,
0.008351334,
-0.01761952,
0.007354755,
0.0063149906,
0.016011706,
-0.024064066,
0.021738715,
-0.01132114,
0.022217073,
-0.007853044,
-0.006706978,
0.024356397,
0.0051091295,
0.004182311,
-0.003886659,
-0.023944477,
-0.029206416,
-0.013181421,
0.0025529037,
-0.014138138,
-0.00934127,
0.012643268,
-0.006135606,
-0.023545846,
-0.0010572044,
-0.002828624,
-0.0005518558,
-0.016011706,
0.01164669,
0.0067136222,
-0.0014101596,
-0.01178621,
-0.014815811,
-0.011812786,
-0.035398494,
0.012018746,
-0.0019582782,
-0.002061258,
-0.017127875,
0.024436124,
-0.0051058074,
0.0018337058,
-0.005388172,
-0.012802721,
0.0030445496,
-0.009759833,
0.18911088,
-0.02498092,
-0.011566963,
-0.00090854807,
-0.015613074,
0.0020878336,
0.0016476776,
0.0019067883,
-0.006231942,
0.014616496,
0.02539284,
0.008949282,
0.0010405948,
-0.001388567,
0.009912642,
-0.0017971646,
-0.012982106,
0.0077002356,
-0.010836138,
-0.0015712733,
0.0071222195,
-0.012649912,
0.02696079,
0.0013080103,
0.02771819,
-0.0111351125,
-0.015825678,
0.0073148916,
0.012882448,
-0.009447571,
-0.025937635,
0.013068476,
-0.0065010185,
0.0073613985,
0.010982303,
-0.0009542246,
-0.020463094,
0.01231772,
0.027399285,
0.0071487953,
0.00182374,
-0.03478726,
-0.02668175,
-0.008032429,
0.0051190956,
0.02503407,
0.005129061,
-0.020449806,
-0.009992368,
0.014948688,
-0.037072748,
-0.0016966761,
-0.0070292056,
0.021393234,
-0.0035013151,
0.0044181678,
0.023851464,
0.02981765,
-0.003889981,
0.027797917,
-0.029551897,
0.011659977,
-0.002454907,
0.01727404,
-0.018244045,
0.022323376,
0.00019049196,
-0.002351927,
-0.0015264272,
-0.017818836,
0.009746545,
-0.0002059597,
-0.015187868,
0.016676093,
-0.021991182,
-0.017181026,
0.017991576,
0.005341665,
0.0017871988,
0.01978542,
0.0036308703,
-0.014975264,
-0.039756868,
0.0130419005,
0.0011601844,
-0.003408301,
0.01231772,
0.014231152,
-0.026602022,
-0.006182113,
-0.0016111365,
-0.030854093,
-0.0084576355,
0.009314694,
0.022655569,
-0.012251281,
-0.0011884207,
-0.023040911,
-0.016556503,
-0.017792262,
-0.020968027,
0.0742518,
0.052619383,
0.0028967236,
-0.018629389,
0.009533942,
0.00011595615,
0.010278054,
-0.022735294,
-0.022894748,
0.0032837286,
-0.025259962,
-0.0001355763,
-0.008318115,
-0.009095446,
0.01164669,
0.021752004,
-0.015772527,
0.03000368,
0.002933265,
-0.014722797,
-0.015559924,
0.015533349,
0.02561873,
-0.01149388,
0.006132284,
-0.028063672,
0.015094854,
0.019041307,
-0.03776371,
-0.019307062,
0.025725031,
-0.006922904,
0.01599842,
0.001006545,
-0.0012540289,
-0.0005252803,
-0.021898167,
-0.01856295,
0.021924743,
-0.015400471,
-0.012915667,
0.023001049,
0.012889092,
-0.002444941,
0.007401262,
0.028143398,
0.025259962,
-0.04488593,
-0.022283511,
-0.0017656062,
-0.022961186,
-0.0008695154,
-0.0019416686,
0.025326401,
-0.01651664,
0.0008969213,
-0.014377316,
0.02019734,
-0.0070491373,
-0.031545054,
0.012477173,
0.014802524,
-0.027425861,
0.0013428906,
-0.008882843,
-0.16646859,
0.009952505,
0.023333242,
-0.005507761,
0.024356397,
0.00567718,
0.000695114,
0.007248453,
-0.008703459,
0.022044333,
0.03704617,
-0.012244637,
-0.037870012,
-0.0033584721,
-0.0038135767,
0.0146696465,
-0.0064976965,
0.014922113,
0.00311431,
0.01902802,
0.031119848,
-0.03537192,
0.000755324,
-0.027425861,
0.008331402,
0.002493109,
0.011593538,
-0.022828309,
-0.0011385918,
-0.02264228,
0.0062618395,
0.011653333,
0.033591364,
-0.007786606,
0.016835546,
0.010756412,
-0.0026143596,
0.0036607678,
0.0065475255,
0.011600182,
0.03380397,
0.026004074,
-0.013201353,
0.008763254,
-0.01316149,
0.021140767,
-0.00750092,
-0.007520851,
0.030774366,
-0.02678805,
0.028621756,
-0.02731956,
0.00574694,
0.017074725,
0.036913294,
0.023997629,
0.025286537,
0.011852649,
0.014643071,
-0.0012797739,
0.0037105968,
0.004843375,
0.028169973,
-0.0019815317,
-0.002596089,
-0.037949737,
-0.01140751,
0.017287329,
-0.017473357,
0.01447033,
-0.018948294,
-0.00977312,
0.009607024,
-0.021858305,
0.012257924,
0.0282497,
-0.015772527,
-0.009733257,
0.008829692,
-0.0115271,
-0.03470753,
0.01832377,
-0.018629389,
-0.01053052,
-0.026070513,
0.009141954,
0.016450202,
0.017406918,
-0.004574299,
0.006577423,
0.019586105,
-0.035557948,
0.0037803573,
-0.026415994,
0.023891326,
0.026190102,
-0.011048742,
-0.0072683846,
-0.012530323,
0.018403497,
0.015838966,
-0.031545054,
-0.0063349223,
0.009799696,
0.0018636031,
-0.011507168,
-0.01856295,
0.0019532952,
0.047171418,
-0.020941451,
-0.023944477,
-0.0018868567,
0.0066039986,
0.025911061,
-0.002255591,
0.027399285,
0.009494078,
-0.0013528563,
0.005580844,
-0.017207602,
0.06845835,
-0.010344492,
-0.0035876853,
0.017579658,
-0.012497104,
-0.012629981,
-0.13776712,
0.0017091334,
0.008942638,
-0.005909715,
-0.0029382478,
0.019386789,
-0.0130485445,
0.015360608,
-0.0060658455,
0.0122845005,
-0.006102387,
-0.0003203587,
-0.009673462,
-0.024143793,
0.019160897,
0.0074344813,
0.006052558,
-0.010497301,
-0.034016572,
0.02071556,
-0.0027256443,
-0.013606628,
-0.000104381295,
-0.017752398,
0.012171554,
0.010437506,
-0.026628597,
0.025539003,
0.002833607,
0.018469935,
-0.012583474,
-0.0047271075,
0.03319273,
-0.007919483,
0.006202045,
-0.00249477,
-0.022203786,
-0.015546636,
0.03045546,
-0.019346924,
-0.008105511,
0.016649516,
-0.011593538,
-0.02369201,
-0.03372424,
-0.0107697,
-0.00989271,
0.008563938,
0.01920076,
-0.020117613,
-0.010743124,
-0.03880015,
-0.028223123,
-0.026641885,
0.03351164,
0.0029399088,
-0.002210745,
0.013952109,
-0.0070358496,
0.01546691,
-0.0032372216,
-0.012709707,
0.0039232,
0.0011045419,
0.025419414,
-0.00287347,
-0.012683132,
-0.008112155,
0.027532162,
-0.004863307,
0.0050161155,
-0.0030877346,
-0.025698457,
-0.0066671153,
-0.0068431776,
0.011361003,
-0.0038501178,
-0.015918693,
-0.005962866,
-0.016702669,
-0.014390605,
-0.028914087,
0.006391395,
0.0060459143,
0.037444804,
0.001419295,
0.0016177803,
-0.009115378,
0.020782,
-0.002444941,
-0.0026542228,
0.052672535,
0.027877644,
-0.015400471,
-0.009281475,
0.018124454,
-0.009108734,
-0.0022788446,
0.02468859,
0.030083405,
-0.023705298,
0.012942242,
-0.053496372,
0.0083579775,
-0.03146533,
0.020263778,
0.040288378,
-0.023253515,
-0.001102881,
-0.026336268,
0.025897773,
0.021619126,
0.00089027744,
0.01658308,
-0.0004949677,
0.020449806,
-0.027558738,
-0.024010915,
0.048473615,
-0.002549582,
0.013121626,
0.036275484,
-0.0017573014,
0.006863109,
0.0032272558,
0.004859985,
0.004474641,
0.0047802585,
-0.011500524,
0.011108536,
-0.009899354,
0.014550057,
0.010570384,
-0.03887988,
-0.024569001,
-0.00951401,
-0.023266803,
-0.017539795,
-0.002297115,
0.01949309,
0.01412485,
0.018483223,
-0.007062425,
-0.012085184,
0.021021178,
0.002547921,
-0.0073613985,
-0.004328476,
-0.03088067,
0.0005593301,
0.0037637476,
-0.014005261,
0.021433098,
0.0032438654,
0.005507761,
-0.021818442,
-0.006195401,
-0.016011706,
0.033405337,
-0.017845413,
-0.002644257,
-0.020463094,
0.007301604,
0.004461353,
-0.0124705285,
0.009726614,
0.0005003658,
-0.014058411,
-0.03957084,
0.03444178,
-0.008132087,
-0.016503353,
-0.028542029,
0.002067902,
-0.00971997,
-0.0021227137,
0.0028934018,
0.042972498,
-0.015094854,
0.00892935,
-0.013021968,
0.011048742,
0.014629783,
-0.006291737,
0.0022672177,
0.015054991,
0.022044333,
0.0059994073,
-0.012629981,
0.034813836,
0.016822258,
-0.013898958,
-0.017699247,
0.0060259826,
0.010849426,
0.012211418,
-0.01668938,
0.016941847,
-0.002689103,
0.043663457,
-0.01546691,
0.047251143,
0.0146696465,
-0.006803314,
0.01149388,
-0.010470726,
-0.015387183,
0.017260753,
-0.0046307715,
-0.031172998,
-0.02463544,
-0.0019267199,
0.012596762,
0.0076935915,
0.006723588,
-0.01563965,
-0.001966583,
-0.010743124,
0.0002339885,
0.0032422044,
-0.018802129,
0.02642928,
0.006491053,
0.015985131,
-0.01563965,
-0.014696222,
0.006102387,
0.011620114,
0.024569001,
-0.013965397,
0.031093271,
0.009540585,
0.007680304,
0.008862912,
-0.014868963,
0.0027190004,
-0.008610445,
-0.0065574916,
0.014629783,
0.02234995,
-0.048234437,
0.08674226,
0.0021144089,
-0.021446384,
0.01123477,
-0.026136952,
0.020529533,
0.008889487,
0.007520851,
-0.026562158,
-0.042999074,
0.013181421,
0.0075142076,
-0.00025911062,
-0.045603465,
-0.018350346,
0.024382971,
-0.031704508,
0.0073215356,
-0.018695826,
-0.0033402015,
0.00036686574,
-0.028409151,
-0.01675582,
0.0088363355,
-0.017672671,
0.0024100607,
0.00075656973,
0.0044447435,
-0.019984735,
-0.025645306,
0.0178587,
-0.02176529,
-0.048526764,
-0.004617484,
0.014629783,
-0.014031836,
-0.018642675,
-0.041059066,
-0.0020894944,
0.03263465,
-0.009713326,
0.029605048,
-0.026974078,
-0.0121848425,
-0.004165701,
0.011799498,
-0.03898618,
-0.0009915964,
-0.023240227
] |
OBJECTIVE To evaluate the efficacy and relative adverse effects of tricyclic antidepressants in the treatment of migraine, tension-type, and mixed headaches. DESIGN Meta-analysis. DATA SOURCES Medline, Embase, the Cochrane Trials Registry, and PsycLIT. Studies reviewed Randomised trials of adults receiving tricyclics as only treatment for a minimum of four weeks. DATA EXTRACTION Frequency of headaches (number of headache attacks for migraine and number of days with headache for tension-type headaches), intensity of headache, and headache index. RESULTS 37 studies met the inclusion criteria. Tricyclics significantly reduced the
|
[
-0.00858118,
0.0018808518,
0.027687198,
-0.03995736,
-0.015734367,
0.02292722,
0.0027733475,
-0.030807626,
0.0075564627,
-0.03027874,
-0.007014354,
0.025545208,
0.021486005,
0.0088985115,
-0.024725433,
0.017876357,
0.051222637,
0.01048517,
-0.012680049,
-0.0056128055,
0.01709625,
0.013870043,
-0.013413878,
-0.006700328,
-0.010571115,
0.020785231,
0.01923824,
-0.03818559,
-0.009824063,
-0.02053401,
-0.00027683892,
0.006581329,
0.00057599024,
-0.020996785,
-0.015866589,
-0.017479692,
0.005493806,
0.027065756,
0.017506136,
0.016752472,
0.029432522,
-0.0077680172,
-0.0016478113,
0.00671355,
0.0024196547,
0.014676594,
0.012045385,
-0.035752714,
-0.019965457,
0.016818583,
0.009050567,
0.013070102,
0.008977844,
0.026589759,
0.009791007,
-0.017664801,
0.004862448,
0.022821443,
0.011562777,
-0.024421325,
-0.026391426,
0.0073647415,
-0.009665397,
-0.018973796,
-0.007853962,
-0.014729483,
0.012005718,
-0.008495236,
0.022715665,
-0.023746993,
0.024222992,
0.025095655,
0.004855837,
-0.025055988,
0.040116023,
-0.02097034,
0.0029187913,
-0.025122099,
0.015641812,
-0.0013048616,
0.025571652,
0.004733532,
-0.018484576,
0.0010528143,
0.00612847,
0.01906635,
-0.0023899048,
0.0010090158,
-0.004241007,
-0.0021254618,
-0.019383682,
0.016845029,
-0.0156947,
0.019145682,
0.014425374,
0.026021205,
-0.0022642943,
0.025267541,
-0.021023229,
0.00044955334,
-0.016712807,
-0.0204679,
-0.020507565,
-0.008131627,
-0.032156285,
-0.00008279343,
-0.01648803,
-0.006449107,
0.0075564627,
-0.026761645,
-0.021750448,
0.036810484,
-0.029458966,
-0.012574271,
-0.020600121,
0.013724599,
0.028454082,
-0.0007028403,
0.004591394,
-0.028850747,
0.0037121207,
-0.0013850209,
0.021657893,
-0.012342883,
0.025042765,
0.011496666,
-0.01925146,
-0.016646696,
0.010405838,
0.005996248,
-0.027502086,
0.03175962,
0.030701848,
0.001488319,
-0.010366171,
0.002978291,
-0.0058441935,
-0.0012271814,
-0.030543182,
-0.022490889,
-0.007530018,
0.028877191,
-0.014570817,
-0.031283624,
-0.010366171,
0.03223562,
0.01997868,
0.023733772,
0.0047665876,
-0.016025255,
0.005983026,
-0.035408936,
-0.009883562,
0.028004529,
-0.00080448564,
0.0031171236,
0.0026295565,
-0.0046013105,
-0.037788924,
-0.011847053,
0.0062309415,
-0.029141635,
0.023760216,
0.00876629,
0.04143824,
0.008144849,
-0.0019965458,
-0.027607864,
0.019053128,
-0.022014892,
-0.01262716,
0.033266947,
-0.021988448,
-0.008786123,
-0.01483526,
0.0086406795,
0.03120429,
-0.00043839714,
0.0024494047,
-0.021168673,
-0.029088745,
-0.001061078,
0.008045683,
-0.017453248,
-0.010670281,
0.0024576685,
0.010650448,
-0.0024130438,
-0.0072523532,
-0.052571297,
-0.0012337925,
0.011271889,
-0.01759869,
-0.016051698,
-0.6333942,
-0.01734747,
0.0037517871,
-0.017744135,
0.019780347,
0.005351668,
0.021684337,
0.023429662,
-0.0112785,
0.02403788,
0.009334843,
0.024222992,
0.007675462,
-0.016792139,
-0.006399524,
-0.022543779,
-0.020388566,
-0.033187613,
0.028850747,
-0.016633473,
-0.024447769,
0.0062904414,
-0.005870638,
0.009215844,
0.013400656,
-0.009791007,
0.011913164,
0.00919601,
-0.009017511,
0.020388566,
-0.019886125,
0.046938658,
-0.0009090233,
-0.0060359146,
0.04363312,
-0.023337107,
0.010921502,
0.011100001,
-0.0065251347,
0.02262311,
-0.02132734,
-0.0144914845,
0.022570223,
-0.005566528,
-0.012455272,
0.028163195,
0.03170673,
-0.004984753,
0.01226355,
0.011615665,
-0.0038278145,
0.0033699973,
-0.0004404631,
0.007397797,
0.01710947,
-0.021115785,
0.00410548,
-0.0011437166,
-0.015350924,
0.02188267,
-0.0015428604,
-0.001380889,
-0.02403788,
-0.0030675405,
-0.010227338,
0.02225289,
0.0041385354,
-0.00066152104,
0.0046508936,
0.013632044,
0.012600715,
-0.0015064995,
-0.017215248,
-0.007318464,
0.013632044,
0.017056582,
0.01495426,
0.014716261,
-0.015668256,
0.008125016,
0.01648803,
0.0032443868,
0.000101851925,
0.0028708607,
0.050905306,
0.0010197589,
-0.017254915,
0.005870638,
0.010333116,
-0.0046541994,
0.0028163195,
0.018193688,
-0.026708758,
-0.028295416,
-0.017440025,
0.044849556,
0.011899942,
-0.0052062245,
0.019780347,
-0.021803336,
-0.014742705,
0.0042509236,
0.0040294523,
-0.015456702,
-0.024910543,
-0.014689816,
-0.019965457,
-0.0031187763,
0.061932582,
0.0005020288,
-0.005358279,
-0.0064854682,
-0.0179028,
-0.010571115,
0.021010008,
-0.031283624,
0.0023370162,
-0.0043236455,
-0.021869447,
-0.030622516,
0.023165219,
0.002065962,
0.012891603,
-0.013856821,
-0.0052855574,
0.0016990472,
-0.011476832,
0.000080314276,
-0.029934963,
-0.025571652,
0.0032047203,
0.015588923,
0.013751043,
-0.0049054204,
0.01594592,
0.008805957,
0.036889818,
-0.012772604,
0.0020362122,
-0.04603955,
-0.026642647,
0.015126147,
-0.015813699,
0.012243717,
0.0010428976,
-0.028903635,
-0.0030146518,
0.006392913,
-0.020137345,
0.0066672727,
0.00821096,
-0.018987017,
-0.013235379,
0.0072589642,
0.0016519432,
-0.026735201,
-0.027065756,
-0.031045625,
-0.018061467,
-0.019701013,
0.0026427787,
0.00797296,
-0.022292556,
0.00043178606,
-0.030490294,
-0.021935558,
-0.024646102,
0.032262065,
0.007920072,
-0.01692436,
0.003236123,
-0.03683693,
-0.013870043,
0.025902206,
-0.042205125,
0.033637166,
-0.003199762,
-0.028454082,
0.008158071,
-0.0016610335,
-0.019608459,
0.014557594,
-0.0086406795,
0.0021353783,
0.02855986,
-0.014385707,
0.0057351105,
-0.0049087256,
-0.010101728,
0.021657893,
0.0017833384,
0.009493508,
-0.02715831,
0.0056590834,
-0.02335033,
-0.00085034996,
0.0074969633,
0.0025849317,
-0.00007215372,
0.0060656643,
0.041464683,
-0.0068622995,
-0.0013775835,
0.002303961,
0.027660752,
0.0020990174,
-0.009004289,
-0.017202027,
0.022728888,
-0.0014312984,
0.0038972308,
-0.01041906,
-0.029564744,
-0.006730078,
-0.014874927,
0.03223562,
0.013658488,
0.0060425256,
-0.0053979456,
0.0041583683,
0.0076225735,
-0.016501252,
0.018907685,
0.022768555,
-0.011351222,
0.023138775,
0.015906256,
0.0026493897,
0.006379691,
-0.00035617186,
-0.0020824897,
0.0035303158,
0.0046442826,
0.017744135,
0.034271833,
0.030754738,
0.0076952954,
-0.0083828475,
0.022689221,
0.008098572,
0.004621144,
0.032156285,
-0.015403813,
-0.009652175,
-0.0032427341,
0.014438596,
0.015721144,
-0.0017916022,
0.028639192,
0.022795,
0.0025303904,
0.01250816,
-0.002497335,
-0.02377344,
0.0043798396,
-0.0037550926,
0.011516498,
0.034536276,
0.04315712,
0.02451388,
0.01317588,
-0.002568404,
0.012713104,
0.013400656,
0.01250155,
-0.0026361675,
-0.000511119,
0.032764506,
-0.022226445,
-0.029776298,
-0.019225016,
-0.006888744,
0.01066367,
-0.045457777,
0.025650986,
0.0001087729,
-0.012825493,
0.0026394732,
0.005093836,
0.009962895,
-0.029987853,
-0.03525027,
0.012613938,
0.013275046,
0.008310126,
-0.01611781,
0.011014056,
0.010181061,
0.0053483625,
0.009215844,
-0.008475402,
0.008415903,
-0.017400358,
0.013136213,
0.0043269508,
-0.02053401,
0.026748424,
0.0017899495,
-0.009281954,
-0.02924741,
0.013949376,
0.0046971715,
-0.007007743,
-0.010743002,
-0.009493508,
-0.015575701,
-0.029617632,
-0.016157476,
-0.011146278,
-0.010062061,
0.019965457,
0.0066176895,
0.000687139,
0.01839202,
0.0020857952,
0.022821443,
-0.0032080258,
-0.00075738167,
0.04826087,
-0.009817451,
0.0056656944,
-0.023125554,
0.0069416324,
-0.0002547331,
0.018841574,
0.0019849762,
-0.014213819,
0.005338446,
0.02813675,
0.01213794,
0.0011891677,
-0.007576296,
0.00876629,
0.018378798,
0.0038906196,
-0.014901371,
0.014121263,
0.010895058,
0.014755927,
0.028692082,
-0.0023353635,
-0.028163195,
0.0025353485,
0.0064259684,
0.021803336,
0.014147708,
0.020256344,
0.041094463,
0.025360098,
-0.011126445,
0.030093629,
0.04775843,
0.0182598,
-0.0040162303,
0.006135081,
-0.0015015412,
-0.006769744,
0.034456942,
-0.030437406,
-0.0047533656,
0.004131924,
0.00536489,
0.017611913,
-0.014795594,
0.014319596,
0.00480956,
0.0017585469,
0.0043434785,
-0.0061681364,
-0.0054045566,
0.027237643,
-0.008329959,
0.0064127464,
-0.0028378055,
-0.006369774,
0.026933534,
0.00011590047,
-0.010571115,
0.020507565,
-0.009308399,
-0.017704468,
-0.0046971715,
-0.004188118,
-0.007331686,
-0.004488922,
-0.013235379,
0.020798452,
-0.035038717,
0.0054905005,
-0.011232222,
-0.0071002985,
-0.0011850358,
-0.010366171,
0.013367601,
-0.019330794,
-0.017426804,
-0.01710947,
0.03702204,
0.024791544,
0.018801907,
0.029855631,
-0.010313283,
0.011291722,
0.028639192,
-0.025333652,
-0.010247172,
-0.002302308,
-0.01397582,
-0.019753903,
-0.005507028,
0.00020329066,
0.023429662,
0.010167839,
0.0072920197,
-0.0025551817,
-0.028480526,
0.018828351,
-0.037603814,
-0.01035956,
0.0045847828,
0.0089514,
0.0081382375,
-0.011939608,
-0.012389161,
0.015112925,
-0.001728797,
0.0029733325,
-0.04032758,
0.0025750152,
-0.005503723,
-0.008561347,
0.014769149,
0.009460453,
-0.015350924,
0.0047070878,
-0.0051533356,
-0.021287672,
0.013394045,
0.04027469,
0.027554976,
-0.024725433,
0.013737821,
-0.0008974539,
-0.0074308524,
-0.00852168,
0.0015932699,
0.030781182,
-0.021036452,
-0.031230735,
0.01287177,
0.0023849467,
-0.013479989,
-0.022821443,
0.0013032089,
-0.0025865845,
0.034721386,
0.005873943,
0.000023861861,
-0.03517094,
-0.004237701,
-0.038952474,
0.024606435,
-0.015350924,
-0.018339131,
0.009962895,
0.010181061,
-0.03916403,
-0.020891009,
0.020494344,
-0.025598096,
-0.027131867,
-0.010696725,
-0.027502086,
0.026801312,
0.016897917,
-0.013506433,
-0.01390971,
-0.004059202,
-0.022451222,
-0.036625374,
-0.0010040576,
-0.0072589642,
-0.0007891975,
0.014438596,
0.03831781,
0.01648803,
0.00294193,
0.0028444165,
0.00054210844,
0.011192556,
-0.0031832343,
0.014385707,
-0.036757596,
0.00772174,
-0.0025237792,
-0.01906635,
0.020388566,
-0.013037046,
0.0067399945,
0.016236808,
-0.02569065,
-0.037127815,
-0.01611781,
-0.03995736,
0.0019287822,
0.021525672,
0.0047798096,
0.00056979235,
-0.028533414,
0.017678024,
0.038079813,
0.019595237,
-0.006968077,
0.02169756,
0.018101133,
-0.013446934,
-0.00050120236,
-0.013248601,
0.009281954,
-0.008647291,
-0.004112091,
-0.021010008,
-0.049133535,
0.015919477,
0.021049675,
0.005949971,
0.010769447,
-0.010795891,
-0.024619656,
0.018841574,
-0.012369328,
0.022874331,
-0.01918535,
-0.0026923618,
-0.017069805,
0.002862597,
-0.030040741,
-0.009143122,
0.021829782,
0.024302324,
0.0014122917,
0.020983564,
-0.019079573,
-0.0050310306,
-0.01611781,
-0.03641382,
0.038159147,
-0.032314952,
0.014676594,
0.0064193574,
0.00950012,
0.014319596,
0.010584337,
-0.018616797,
-0.019013463,
0.030252295,
0.033610724,
0.009771174,
0.009348065,
0.010862002,
0.0023551967,
-0.045510665,
-0.007596129,
0.0021552115,
0.023614772,
-0.0038972308,
-0.0028278888,
-0.017863134,
-0.021195117,
0.03990447,
-0.011734664,
0.0052326685,
0.008726624,
-0.019106017,
-0.013149435,
0.059552595,
-0.036598932,
0.015350924,
0.006062359,
0.01048517,
-0.004740143,
0.002984902,
-0.020811675,
-0.0018048245,
-0.009328232,
0.016078142,
-0.009295177,
-0.0022692527,
0.0030096935,
0.0038443422,
0.0024857656,
-0.017479692,
-0.0071002985,
0.041782018,
-0.0044591725,
0.0005169037,
0.0047599766,
-0.012673438,
0.0010850433,
-0.021591783,
-0.01992579,
-0.008673735,
-0.020256344,
-0.019145682,
0.022424778,
0.0025270847,
-0.033240505,
0.0022279334,
-0.017241692,
-0.015853366,
0.009506731,
-0.0031154708,
-0.0012941186,
-0.033240505,
-0.0010065367,
-0.009420787,
-0.023641217,
0.03525027,
-0.0068556885,
-0.0009842243,
0.0106901135,
-0.003824509,
-0.020348899,
0.01342049,
0.008442347,
0.011747886,
-0.026431091,
0.011040501,
-0.0064755515,
-0.052280407,
-0.004217868,
-0.028982969,
-0.044214893,
-0.02329744,
-0.008237404,
0.00741763,
-0.0027568198,
-0.024170103,
0.0060458314,
0.0024642795,
0.010445504,
0.01453115,
-0.028665636,
0.028427638,
-0.017056582,
-0.0041385354,
0.023733772,
-0.0072986307,
-0.017982133,
-0.02439488,
0.010465337,
-0.0012883339,
-0.023932105,
0.0025188208,
-0.026047649,
0.022913998,
-0.024791544,
0.015337702,
0.020943897,
-0.008792735,
-0.010571115,
0.022345446,
0.008012627,
0.0008817526,
-0.0035534548,
-0.014081597,
-0.0027683892,
0.0029733325,
-0.010795891,
-0.00557975,
-0.01465015,
-0.0084092915,
-0.021300895,
-0.01397582,
0.004003008,
0.03879381,
0.014888149,
-0.011304944,
-0.012951103,
-0.028824301,
-0.045669332,
0.00398648,
-0.0031485262,
0.008607624,
0.026867423,
0.0055500004,
0.007139965,
0.005113669,
0.018801907,
-0.013446934,
-0.018180465,
0.003926981,
-0.0036460098,
0.0084092915,
0.013314712,
-0.0013998959,
-0.03882025,
-0.014941038,
0.02188267,
-0.027211199,
-0.03255295,
-0.004009619,
0.022504112,
0.014967482,
-0.008872068,
-0.016514475,
-0.0018147411,
-0.033002503,
0.012435439,
-0.014385707,
0.008277071,
-0.014346041,
0.014253485,
0.0043732286,
-0.011575999,
0.002976638,
0.0029601103,
-0.0064226626,
-0.054025732,
-0.036757596,
-0.010875224,
-0.035884935,
-0.009705063,
0.02397177,
0.003487344,
0.014888149,
-0.017572246,
-0.012303217,
-0.01955557,
0.007397797,
-0.0071796314,
0.00523928,
0.021935558,
-0.0063102744,
-0.003983175,
0.004178202,
0.012309828,
0.0077085174,
0.017175581,
-0.029644076,
0.005308696,
-0.009176177,
0.008686957,
0.0081514595,
-0.013645266,
-0.0031154708,
-0.0037484816,
-0.029168079,
0.009923229,
-0.020348899,
0.0068622995,
-0.04656844,
0.010967779,
0.013552711,
-0.029644076,
0.023218108,
-0.00045079293,
-0.008058905,
-0.017188804,
0.020005124,
0.16511829,
0.025809651,
-0.015112925,
0.022160335,
-0.004816171,
-0.0012114801,
0.026378203,
0.020362122,
-0.008984456,
0.02948541,
0.03953425,
-0.0019023379,
-0.010181061,
0.0064193574,
0.021340562,
-0.029432522,
-0.009229066,
-0.014557594,
0.007278797,
-0.010148006,
0.005229363,
0.005374807,
0.010584337,
-0.015668256,
0.020547232,
0.009103455,
-0.0039435085,
-0.014028708,
0.024368435,
-0.010319893,
-0.024236213,
-0.008085349,
0.015853366,
0.010148006,
-0.019330794,
-0.0067763557,
-0.00986373,
-0.011490054,
-0.01710947,
-0.003315456,
-0.012944492,
-0.010386004,
-0.028163195,
0.000893322,
-0.00499467,
0.03022585,
0.022913998,
-0.025703873,
0.00054210844,
-0.0014932774,
-0.0409358,
-0.0029468883,
0.008085349,
0.007913461,
-0.020005124,
-0.020348899,
0.05153997,
0.011179334,
0.005738416,
0.0035534548,
0.0003200175,
-0.002656001,
-0.019621681,
-0.007741573,
0.005725194,
-0.018828351,
-0.012316439,
0.00312704,
-0.0015858324,
-0.00041959688,
-0.009434009,
-0.017982133,
-0.018180465,
0.008224182,
-0.013017214,
-0.016316142,
0.025055988,
0.026721979,
-0.002991513,
0.015298036,
-0.012104885,
-0.010901668,
0.014676594,
0.02795164,
-0.0140022645,
-0.012918048,
0.01152311,
0.03403383,
0.0027683892,
0.010280227,
0.0032989283,
-0.0011222305,
-0.011205778,
-0.008257237,
0.026536869,
0.015866589,
-0.022649555,
-0.018987017,
0.009143122,
0.0041484516,
-0.026695535,
0.08218893,
0.006085498,
0.0017469774,
-0.01397582,
-0.0037815368,
-0.020269567,
-0.013195713,
-0.006908577,
0.011133056,
-0.0014569164,
-0.020692676,
0.010624004,
-0.01765158,
-0.01544348,
0.020507565,
0.013936154,
-0.05040286,
0.008389459,
-0.014372485,
0.012389161,
-0.015258369,
0.0066838004,
0.0033534695,
-0.009057177,
-0.0041286186,
-0.009764563,
0.0040294523,
0.03683693,
-0.03617582,
0.012620549,
-0.018035023,
0.02065301,
0.017995356,
-0.014425374,
0.009162955,
0.037286483,
0.010352949,
0.013327934,
0.013142824,
0.0052855574,
-0.013870043,
0.0145179285,
0.0062177195,
-0.0030311795,
-0.005827666,
-0.015179036,
-0.0060160817,
-0.045933772,
-0.012276772,
0.01587981,
-0.008971234,
0.019436572,
0.0032262064,
0.02690709,
0.014319596,
-0.023337107,
-0.015787255,
0.018101133,
0.03400739,
-0.03567338,
0.0033749556,
0.027792973,
-0.008475402,
-0.005302085,
-0.00057351106,
-0.16501252,
0.011913164,
0.019225016,
-0.005847499,
0.03599071,
-0.0060392204,
0.031521622,
0.0007044931,
-0.0084092915,
-0.014068375,
-0.017387137,
0.025095655,
-0.02850697,
-0.021406673,
0.013830376,
0.014980704,
-0.005830971,
0.005245891,
-0.0029287077,
0.016712807,
0.00013325455,
-0.0067829667,
0.00048756704,
-0.010895058,
0.0156947,
0.023561884,
-0.011761108,
0.02451388,
0.01152311,
0.0008544819,
-0.013565933,
0.008283681,
0.045272667,
0.018524243,
0.02048112,
0.021049675,
-0.00017849912,
0.0017486303,
-0.003350164,
0.0034245388,
-0.0030824153,
0.009315009,
0.018233355,
0.0037220372,
0.0027155005,
0.0112785,
0.008561347,
-0.029934963,
-0.014584039,
0.0081382375,
-0.0033319835,
-0.016501252,
0.029088745,
-0.0039005363,
0.048287317,
0.013645266,
0.023178441,
-0.008574569,
0.019264683,
-0.05204241,
0.007397797,
-0.023310663,
0.022385111,
0.0040360633,
0.008495236,
-0.029934963,
-0.00003246143,
-0.008244015,
-0.006247469,
0.034906495,
-0.042390235,
-0.022160335,
0.003098943,
-0.017069805,
0.010108339,
0.0318654,
0.0028444165,
0.010815725,
0.014689816,
0.0032658728,
-0.0058441935,
0.0057979156,
-0.03125718,
-0.0031039014,
0.017823467,
0.003191498,
0.014822038,
0.014623705,
-0.0066243005,
-0.007490352,
0.02457999,
-0.021195117,
0.021776892,
-0.01011495,
0.010273616,
-0.007992794,
-0.009817451,
0.017373914,
0.006442496,
-0.011701609,
0.0089117335,
-0.0017684635,
-0.01164872,
0.018312687,
0.014068375,
0.015655033,
-0.0035666768,
0.01293127,
0.015985588,
0.0014007223,
-0.007946516,
0.012237106,
0.009387732,
0.017321026,
0.016051698,
0.017294582,
0.0015436868,
-0.013751043,
0.0030328322,
-0.0073647415,
0.059552595,
-0.0032675255,
-0.013552711,
-0.03450983,
-0.012104885,
-0.027184755,
-0.12122074,
0.00010427943,
0.008508458,
-0.02262311,
-0.007166409,
0.02972341,
-0.00423109,
0.018484576,
0.00723252,
0.02636498,
-0.02164467,
0.0134998225,
-0.006710245,
-0.009711674,
0.026999645,
-0.019648125,
0.009705063,
-0.026682314,
-0.027078977,
0.05222752,
-0.014240263,
0.012223884,
-0.009367898,
-0.023641217,
0.0012999033,
-0.009110066,
-0.016157476,
0.019410126,
0.00023551968,
0.03530316,
0.0075630737,
-0.0024130438,
0.00999595,
0.029220967,
-0.0064028297,
0.008012627,
0.0049550035,
-0.014438596,
0.029882075,
-0.041887794,
0.011787553,
0.010881836,
0.029511854,
-0.0038773976,
0.022781776,
-0.017717691,
-0.020613343,
0.00091728714,
0.004383145,
-0.0049814475,
-0.02323133,
-0.011344611,
0.0029270551,
0.005870638,
0.023998216,
0.007397797,
0.011847053,
0.014980704,
-0.02893008,
-0.0033468585,
0.010828947,
0.0020857952,
-0.019449793,
0.025452653,
0.016157476,
-0.000047284706,
-0.003979869,
-0.007853962,
-0.0055566113,
-0.032500062,
-0.008244015,
0.022953665,
-0.024844432,
0.009420787,
-0.040803578,
0.0072523532,
-0.02065301,
0.0053285295,
0.022001669,
0.0031881926,
-0.025836095,
-0.012951103,
-0.0129709365,
-0.0015626937,
0.006333413,
0.024236213,
-0.0013321324,
-0.010617392,
-0.0010982654,
-0.0409358,
0.003536927,
0.030490294,
0.012455272,
0.010954557,
0.007146576,
0.002533696,
0.021591783,
-0.010795891,
0.026087316,
0.008415903,
-0.029141635,
-0.014068375,
-0.05333818,
0.016236808,
0.026999645,
-0.002403127,
0.023984993,
0.008415903,
0.03953425,
-0.00043963673,
-0.0064259684,
-0.01710947,
-0.008607624,
-0.012177607,
-0.011192556,
0.017797023,
-0.00487567,
-0.009506731,
0.022980109,
-0.0044228113,
0.014570817,
0.015707923,
-0.011060335,
-0.0052888626,
0.027502086,
0.033240505,
-0.027184755,
-0.0023700716,
0.00020484014,
0.01397582,
-0.024289103,
0.016831806,
0.0016783875,
-0.02114223,
0.0009205927,
0.009447231,
-0.031627398,
-0.023680883,
-0.023469329,
0.038026925,
0.011192556,
0.0017469774,
-0.032896727,
-0.020058012,
0.038026925,
-0.022451222,
-0.010557893,
-0.002862597,
-0.026312092,
0.0016345892,
-0.008111794,
-0.0026411258,
0.02169756,
0.0077085174,
0.0038807031,
-0.007569685,
-0.019317571,
0.024064327,
0.0047665876,
0.0069416324,
-0.01851102,
-0.0067267725,
0.00073878805,
-0.022768555,
-0.014372485,
0.0025750152,
0.00076234,
-0.0013833682,
-0.0035303158,
-0.009334843,
0.018947352,
-0.0001141444,
-0.006968077,
-0.016527696,
0.0069416324,
0.0081514595,
0.006835855,
0.020005124,
-0.009341454,
0.030913403,
-0.0036856763,
0.0021122396,
-0.0043798396,
-0.006710245,
-0.034589164,
-0.00240478,
0.007331686,
0.0031402623,
-0.031733178,
0.021909114,
-0.017889578,
-0.013922932,
0.010366171,
-0.011291722,
-0.0038212035,
0.0012453619,
-0.010769447,
0.042707566,
-0.022451222,
-0.019634902,
0.026774868,
0.022292556,
0.01520548,
0.012289995,
0.0028675552,
-0.024328768,
-0.011946219,
0.013803932,
-0.037736036,
-0.024817988,
-0.029511854,
0.0074506854,
0.0088985115,
0.019939013,
-0.0049186423,
-0.006118553,
0.0018858102,
-0.01716236,
0.009275343,
0.008415903,
-0.0025568346,
0.017545803,
-0.020296011,
0.030490294,
0.020084456,
0.0012875076,
0.021340562,
0.00084580487,
0.027131867,
-0.02292722,
0.025809651,
0.0075035742,
0.0035534548,
-0.005467362,
-0.029088745,
0.01618392,
0.016210364,
-0.033769388,
-0.017400358,
0.02893008,
-0.00472031,
0.06991877,
-0.0072920197,
-0.0036856763,
0.003343553,
0.00029233363,
0.009605897,
-0.0076952954,
0.026444314,
0.005817749,
-0.027316976,
0.014187374,
-0.001786644,
0.021565339,
-0.042760454,
-0.02874497,
0.0026130287,
-0.008931567,
0.016977249,
0.0028791246,
-0.013579155,
0.029564744,
-0.007576296,
0.013896487,
-0.02335033,
-0.021248007,
-0.021446338,
0.010035617,
-0.007265575,
-0.022173557,
-0.03985158,
0.0044757,
-0.008171293,
-0.009777785,
0.003794759,
0.013579155,
-0.032341395,
-0.01642192,
-0.009830674,
0.014663372,
-0.00079208985,
-0.011807386,
0.012316439,
-0.0030906792,
-0.01685825,
-0.0048822816,
-0.038635142,
0.016937584,
0.008938178,
-0.018048244
] |
Antisense transcription is widespread in many genomes; however, how much is functional is hotly debated. We are investigating functionality of a set of long noncoding antisense transcripts, collectively called COOLAIR, produced at Arabidopsis FLOWERING LOCUS C (FLC). COOLAIR initiates just downstream of the major sense transcript poly(A) site and terminates either early or extends into the FLC promoter region. We now show that splicing of COOLAIR is functionally important. This was revealed through analysis of a hypomorphic mutation in the core spliceosome component PRP8. The prp8 mutation pertur
|
[
-0.042715788,
-0.012265612,
-0.0014581799,
-0.023013545,
-0.015025031,
0.01687384,
-0.014293784,
0.011237729,
-0.014735292,
-0.01739813,
0.008830138,
0.00008057285,
-0.008561094,
0.0047186045,
0.004684112,
-0.004559938,
0.027552787,
-0.0045254454,
0.003711417,
-0.003066403,
0.008574891,
0.021440677,
-0.025359051,
-0.0049324594,
0.001829839,
0.0088508325,
0.0147766825,
-0.040839385,
-0.038769823,
-0.037196953,
0.014279988,
0.015369957,
-0.0012322526,
-0.004066692,
-0.025690181,
-0.032257594,
-0.0035061853,
-0.017439522,
0.005884459,
-0.01298996,
0.03228519,
0.004052895,
-0.02061285,
0.009485499,
0.0058948062,
-0.0099270055,
0.0021385488,
-0.011955178,
-0.011824106,
0.025441833,
0.020240331,
0.013314191,
-0.026862932,
-0.014666306,
-0.012907177,
-0.011368802,
0.013562539,
0.014900857,
-0.00012826982,
-0.0050083436,
0.015977029,
-0.006708835,
-0.029001482,
0.015949436,
-0.000943376,
0.019633258,
-0.013141728,
-0.013824684,
-0.0017410202,
-0.010989382,
0.033913247,
0.026048904,
-0.007381443,
0.0011615425,
0.011396396,
-0.024407052,
0.006926139,
0.018419115,
-0.003380287,
0.027828729,
0.017025609,
0.00050574954,
0.011334309,
0.022199517,
0.0051359665,
0.0040563443,
0.009471701,
0.03360971,
-0.015756276,
0.011306715,
0.0039321706,
0.045668367,
0.032588724,
0.022434067,
-0.02304114,
-0.0027421715,
0.018281143,
0.019509085,
-0.009499296,
-0.022033952,
0.004256402,
0.00886463,
-0.033113014,
-0.013058946,
-0.024820965,
0.00038696526,
0.009250948,
0.008361036,
0.02232369,
-0.009202658,
-0.015163002,
0.03217481,
-0.0024920993,
-0.036231156,
0.02341366,
-0.037196953,
0.0040218513,
0.0005117858,
-0.04199834,
-0.008147181,
0.020212736,
0.03830072,
-0.0009011224,
-0.022820385,
0.036921013,
0.005191155,
-0.024724385,
-0.0029715481,
-0.042908948,
-0.009782136,
0.013148626,
0.032864667,
0.026655978,
0.006622603,
-0.01634955,
0.0026559397,
-0.02924983,
-0.0013296945,
-0.01071344,
-0.02413111,
0.011023874,
0.04152924,
-0.037583273,
0.0021161286,
-0.0012451874,
0.004639271,
0.03236797,
-0.0001821647,
0.011292918,
0.006926139,
0.0068192114,
-0.023206705,
0.0012883032,
0.0060845166,
0.021440677,
0.030988263,
0.009457905,
0.009050891,
-0.013824684,
0.0047324016,
0.021026764,
0.0029905192,
0.021109547,
0.017991405,
0.019219346,
0.013300395,
-0.004559938,
-0.011030773,
0.008285152,
-0.0032267943,
0.011299816,
0.012079352,
-0.02971893,
0.012569148,
0.011030773,
0.017839637,
-0.007588399,
0.02617308,
-0.0044771554,
-0.015756276,
0.003171606,
0.014597321,
0.015094016,
0.0065915594,
-0.026973309,
0.0050980244,
0.011106657,
0.0030819247,
-0.003811446,
-0.018474303,
-0.018101782,
0.01104457,
0.024958935,
-0.0038735329,
-0.6269398,
-0.013162423,
0.012169033,
-0.05587821,
0.0026749107,
0.007816051,
0.0055498793,
0.00018087123,
-0.016818652,
0.029415395,
-0.013003757,
0.01687384,
0.027525194,
-0.017411927,
-0.018350128,
-0.037886806,
0.013252105,
-0.013141728,
0.039652836,
0.0013822959,
-0.021413082,
0.014293784,
0.014624915,
-0.0016392667,
0.00293878,
0.01957807,
0.03090548,
-0.011292918,
-0.024972731,
0.0010891077,
-0.01445935,
0.018626072,
-0.02090259,
0.0032336928,
0.065618955,
0.010975584,
-0.0001653495,
0.002071288,
0.02531766,
0.03294745,
0.0018902012,
0.0015901146,
0.020033374,
-0.025703978,
-0.009547586,
0.029194642,
0.017356738,
0.0060603716,
0.010161556,
-0.018432911,
0.004842778,
0.0057844296,
-0.008002312,
-0.010603063,
-0.014500741,
0.029553365,
0.04536483,
-0.0068054143,
0.020116156,
-0.0056671547,
-0.022475459,
0.030877886,
-0.023662008,
-0.008588688,
0.007836747,
-0.021840792,
-0.020516273,
-0.005922401,
0.010554774,
-0.010837614,
0.031043451,
0.019095171,
-0.017480912,
-0.007609095,
-0.016101204,
0.019136563,
0.0070641097,
-0.009264746,
0.0045219962,
0.027138876,
-0.004446112,
0.002293766,
-0.01739813,
0.010133962,
0.00091319485,
-0.009561383,
-0.019854011,
0.018267347,
0.012348395,
-0.022365082,
-0.011230831,
0.011610251,
-0.011175643,
-0.04152924,
-0.014079929,
0.019191751,
-0.021882184,
0.0106927445,
0.014956045,
-0.032781884,
-0.00682611,
-0.0072986605,
-0.010782425,
-0.013017554,
0.0077056745,
-0.0022523748,
-0.0203783,
0.011113555,
0.0020678388,
-0.0057706325,
-0.014956045,
-0.022544444,
-0.014735292,
-0.01825355,
-0.010196049,
-0.024807166,
0.0279667,
-0.0030733016,
0.00896121,
-0.015342363,
0.019660853,
0.0062293857,
-0.012879583,
-0.010127064,
0.0053463723,
-0.008774949,
-0.00034083123,
-0.036562286,
0.00091233256,
-0.0071882834,
0.009444107,
-0.006812313,
0.027511396,
-0.021109547,
0.013541844,
0.008457616,
0.03454791,
0.015369957,
0.025248673,
-0.013245206,
-0.033002637,
-0.0056154155,
0.006119009,
0.017839637,
-0.013610829,
-0.024103515,
-0.035513707,
0.014804277,
0.003994257,
0.008112689,
-0.004632373,
0.013617727,
-0.03598281,
0.014038539,
-0.01014086,
-0.024682993,
-0.02142688,
-0.05386384,
-0.023096329,
-0.017232565,
0.00967176,
-0.0029853452,
0.014093727,
0.024048327,
0.0021402736,
0.003478591,
-0.0022247806,
0.00073814427,
-0.014887059,
-0.028021889,
0.0038321416,
-0.01710839,
-0.009278542,
-0.0015745928,
-0.00071831094,
0.01588045,
-0.0005596444,
0.021647634,
0.0016297812,
-0.01772926,
-0.017453318,
0.0072503705,
-0.023206705,
-0.017177377,
0.010085672,
0.0112170335,
0.034630693,
0.008430022,
0.0050842273,
0.025841948,
0.0070503126,
-0.003801098,
-0.009823528,
0.01654271,
-0.011906888,
-0.016418537,
0.0005635249,
0.006715733,
-0.0017065275,
0.01426619,
0.027814932,
-0.006688139,
0.008540398,
-0.015163002,
0.0024593312,
-0.021744212,
0.013624626,
-0.012907177,
0.0068433564,
0.0011296367,
0.005774082,
0.02650421,
0.0002789599,
-0.008091993,
0.017950013,
0.00025309037,
-0.0004660829,
-0.008616283,
0.0040597934,
-0.0010416802,
-0.016059812,
-0.024862355,
0.0054532997,
-0.007636689,
-0.008609383,
0.01341767,
0.00012503612,
0.0007489233,
0.003256113,
-0.011713729,
0.0023679254,
0.0022730704,
-0.0062259366,
0.019812621,
-0.0030733016,
0.005691299,
0.018515695,
-0.0024869253,
0.041142922,
-0.01000289,
-0.017936217,
0.015245784,
0.0012926148,
-0.026614586,
-0.004004605,
-0.011272222,
0.059713803,
-0.0053877635,
-0.0025990268,
0.022723807,
-0.0056568068,
-0.0070779067,
-0.0028559975,
-0.0035768955,
0.0049738507,
-0.0112170335,
0.008298949,
-0.0032026493,
0.060320877,
0.04602709,
-0.0016728971,
-0.01673587,
-0.007829849,
-0.0044737062,
-0.008885326,
0.018943403,
0.0044771554,
-0.009168166,
-0.015066422,
0.009175064,
-0.022365082,
0.003356142,
0.009747644,
-0.023593023,
0.027056092,
0.022806589,
0.014293784,
0.02991209,
0.010589266,
0.0017479188,
-0.0032440408,
-0.031209016,
0.029222235,
0.018322535,
-0.028946294,
-0.013445264,
-0.018846825,
0.0011425714,
-0.0041460255,
0.006981327,
-0.0072503705,
0.0023972443,
-0.0015211292,
0.012569148,
-0.003949417,
-0.0050359378,
0.014762886,
-0.019329723,
0.016294362,
-0.0032871566,
-0.010458194,
-0.0053774156,
-0.007636689,
-0.010775527,
0.06434962,
0.027511396,
0.009699354,
-0.0027387224,
-0.011479178,
-0.016708275,
0.002564534,
0.000017259836,
-0.0013486654,
0.0071261968,
-0.02033691,
0.0010270209,
0.00010143017,
-0.0030543306,
0.017508507,
-0.014859465,
-0.048289813,
-0.011134251,
0.001694455,
0.010092571,
0.022047749,
0.01066515,
-0.02621447,
0.01910897,
-0.007898834,
0.01512161,
-0.025497021,
-0.015080219,
0.01052028,
-0.03493423,
-0.030188031,
-0.013238307,
0.00094165135,
-0.013052046,
0.016804855,
0.009961499,
0.005532633,
-0.036948606,
-0.024048327,
0.0006527748,
0.00815408,
0.008781848,
0.020461084,
0.050469752,
0.022668619,
0.0033492434,
0.009506195,
0.030463973,
0.00929234,
-0.012879583,
0.0077194716,
0.01891581,
-0.0017643028,
0.023662008,
0.011941381,
-0.008512804,
0.017867232,
0.0031440118,
-0.0059982846,
0.0058430675,
0.04478535,
0.0046910103,
0.012189728,
-0.0053118793,
-0.0045426916,
-0.014928451,
-0.033720087,
0.031981654,
-0.003573446,
-0.015894247,
0.014583523,
-0.021826996,
-0.014569727,
-0.010437498,
0.018529491,
0.002336882,
-0.005908604,
0.008085094,
0.034906637,
-0.039321706,
-0.0003830848,
-0.012920974,
0.0063018207,
0.00210923,
-0.0064397915,
-0.026380034,
0.031981654,
-0.006550168,
0.0062259366,
-0.02113714,
0.004239156,
-0.03454791,
-0.028780729,
0.00021633405,
0.018405316,
0.019922998,
0.0043495325,
-0.024103515,
-0.0060465746,
-0.00016922993,
-0.018101782,
-0.020171344,
0.014652509,
-0.041308485,
0.0032785335,
0.0031164177,
0.03440994,
-0.015728682,
-0.021882184,
0.01251396,
0.0058430675,
-0.017232565,
0.03090548,
0.005939647,
-0.008043703,
0.02640763,
0.029332612,
0.03189887,
-0.0010934194,
-0.02222711,
-0.0050083436,
-0.01986781,
-0.008036804,
-0.011893091,
0.0056050676,
-0.011430888,
0.0033009537,
0.015604508,
-0.010672049,
-0.018998591,
0.010989382,
0.013238307,
-0.0010149484,
-0.008367935,
0.02261343,
0.00369762,
-0.0024627806,
0.033113014,
-0.013624626,
-0.017260158,
0.006529473,
-0.024089718,
0.013017554,
-0.014279988,
-0.017798245,
0.014887059,
0.01521819,
-0.00091233256,
-0.017356738,
0.016252972,
-0.019826418,
0.05005584,
0.01829494,
-0.02146827,
-0.018419115,
-0.003973562,
0.003071577,
-0.0075263125,
-0.0035303303,
0.005711995,
-0.026352441,
0.0036803735,
-0.0073400517,
-0.014024741,
0.0063984003,
-0.031622928,
-0.009775238,
0.022765197,
0.0035630984,
0.019081375,
-0.014376567,
-0.005867212,
-0.015797667,
-0.017812042,
-0.0074711237,
-0.033692494,
0.012589844,
-0.022806589,
0.04569596,
0.00972005,
0.02175801,
-0.009823528,
-0.0004958329,
0.025041718,
0.0075194137,
-0.0022696212,
-0.0009761441,
0.019164158,
-0.001938491,
-0.005470546,
0.022006357,
0.015369957,
0.010540976,
-0.016915232,
0.009685556,
0.028118469,
-0.021150937,
-0.0152319865,
0.012155236,
-0.023344675,
-0.046661757,
0.0065053278,
-0.0037045185,
0.01568729,
-0.026518006,
-0.0013253829,
0.023054937,
-0.007029617,
0.020226533,
-0.01668068,
0.048703726,
-0.009961499,
0.035430927,
-0.0028922148,
0.016266769,
-0.007760863,
-0.020309316,
-0.006943385,
0.005670604,
0.039845996,
-0.019619461,
-0.0012072453,
0.0059879366,
0.0008571442,
0.01554932,
0.016404739,
-0.022999749,
-0.009747644,
0.0008916369,
-0.02284798,
0.0032819826,
-0.01730155,
-0.013955756,
-0.05976899,
0.014321378,
0.0027094034,
0.013514249,
0.023910357,
-0.016059812,
-0.022544444,
0.021413082,
0.00263007,
0.032147218,
0.003337171,
0.018267347,
0.017356738,
-0.010009788,
-0.04014953,
-0.019647056,
-0.0052739372,
0.0012753685,
0.037252143,
0.027580382,
-0.018874418,
-0.02678015,
0.023675805,
0.010251237,
-0.012396685,
-0.028973889,
0.0010365064,
-0.0042977934,
0.015894247,
-0.022447864,
0.0051359665,
0.0051566623,
0.012769206,
-0.0050083436,
0.008285152,
-0.01588045,
-0.006394951,
-0.0026662876,
0.009678658,
-0.00067993783,
0.0012710568,
0.016280565,
0.0045909816,
-0.0027663165,
-0.018501896,
0.009050891,
-0.004014953,
0.0036941706,
0.03763846,
-0.01142399,
0.0030991712,
0.027828729,
-0.011258425,
0.002014375,
-0.0011718903,
-0.009313036,
0.030739915,
-0.019136563,
0.0049531553,
0.008802543,
0.010154658,
0.00048246697,
-0.000019307841,
0.012348395,
-0.0128657855,
0.0023351575,
-0.0032198958,
0.02469679,
0.009775238,
-0.03256113,
-0.0027749396,
-0.013121032,
-0.0041494747,
-0.0017194622,
-0.029636148,
0.009526891,
-0.054526098,
-0.009030195,
0.008643877,
0.021081952,
0.014093727,
0.008381732,
-0.0028973888,
-0.0029956931,
0.021578647,
-0.032588724,
0.021978764,
-0.006132806,
-0.0033820115,
-0.018957201,
0.038576663,
-0.007760863,
-0.026890527,
0.003952866,
-0.016225377,
-0.004594431,
0.016625492,
-0.0064673857,
0.0060983137,
-0.0011503323,
-0.021192329,
0.03156774,
0.017798245,
0.005646459,
0.0062328354,
-0.010361614,
-0.00881634,
-0.035817243,
0.008492108,
0.03678304,
-0.009388919,
-0.0009563108,
-0.004156373,
-0.0111687435,
0.0106927445,
-0.015300972,
-0.027332034,
0.0008054051,
0.007484921,
0.0066364002,
0.015314769,
-0.005232546,
-0.020985372,
-0.019302128,
0.0047048074,
0.012541554,
0.0013426293,
0.00013279698,
0.012003467,
-0.007409037,
0.012665728,
-0.021771807,
-0.015300972,
-0.0135349445,
-0.026090296,
-0.050331783,
0.000083752646,
0.009409615,
0.030629538,
0.009775238,
-0.03024322,
-0.017425723,
0.009299238,
-0.038273126,
-0.03474107,
0.0023920704,
0.016432334,
0.012762308,
0.042053528,
0.00886463,
0.007167588,
0.0010408179,
0.013052046,
0.009533789,
-0.015990827,
0.0015271653,
0.016156392,
-0.003413055,
-0.0031181423,
-0.039294112,
-0.008554195,
0.022309894,
-0.010589266,
-0.039928775,
0.040701415,
-0.026297253,
0.014224799,
-0.00019412936,
-0.010941092,
0.0067812693,
0.013824684,
-0.012976163,
-0.021578647,
-0.00022571176,
0.006315618,
0.0025058964,
-0.021302706,
0.01360393,
-0.029139454,
0.016749667,
-0.0035665475,
-0.017094593,
-0.04241225,
-0.0012098323,
-0.009768339,
0.012686424,
0.037472896,
0.009609673,
-0.0032440408,
0.026752556,
-0.028284034,
-0.012976163,
-0.033444144,
0.002952577,
0.0064397915,
0.035817243,
0.009775238,
-0.005884459,
-0.002421389,
-0.013162423,
-0.013955756,
-0.024710586,
-0.0017332594,
-0.00507388,
-0.011051469,
0.0035493013,
0.008257558,
-0.009168166,
-0.0006109524,
0.0010778976,
-0.009913209,
-0.012748511,
0.01152057,
0.00044711193,
-0.00810579,
0.02308253,
-0.0029111858,
-0.026048904,
-0.0036010405,
-0.022875573,
0.0041839676,
-0.019039983,
0.0062638787,
0.19834696,
-0.00056136906,
-0.0029887946,
0.015342363,
-0.0042839963,
-0.0002653784,
-0.0035941417,
-0.019357316,
-0.021247517,
0.0106927445,
0.0175361,
-0.01018915,
-0.016321957,
-0.001282267,
0.0066329506,
-0.008450718,
-0.008347239,
-0.0066950377,
-0.03223,
-0.0013503901,
0.01934352,
-0.0053981114,
-0.012010367,
-0.013521148,
0.020116156,
-0.0018419115,
-0.013024452,
-0.005715444,
0.0031181423,
0.011148049,
-0.034051217,
0.012789902,
0.003161258,
-0.0027852873,
0.0016866942,
0.0031543595,
0.008381732,
0.023772385,
0.014735292,
0.010465092,
-0.006722632,
0.0203783,
0.012783003,
-0.0119827725,
-0.0012296656,
0.010451295,
0.0015219914,
-0.026048904,
-0.043957528,
0.01545274,
-0.048179436,
0.015535522,
-0.0072917617,
0.040839385,
-0.009692456,
-0.00025804868,
0.013872974,
0.0043771267,
0.0035941417,
0.032478347,
-0.0068468056,
0.02360682,
-0.027718352,
-0.0065053278,
-0.0026197224,
0.034851447,
-0.009382021,
0.0023834473,
0.012044859,
-0.018281143,
0.015673494,
-0.022392675,
0.010327121,
0.006698487,
-0.0056809518,
-0.004394373,
0.016984217,
0.019205548,
0.010058078,
0.029111858,
0.008381732,
0.010396107,
-0.042357065,
0.011775816,
0.0014305857,
-0.035486113,
0.029001482,
0.001244325,
-0.019315924,
-0.007422834,
0.02304114,
-0.021192329,
0.0012503612,
0.0083748335,
-0.0019453897,
-0.01957807,
0.013114134,
0.0036010405,
-0.009644166,
-0.02753899,
-0.013838481,
0.046330627,
0.00022571176,
0.02156485,
-0.0020074765,
0.008933616,
0.013334887,
0.014680103,
-0.0015159552,
-0.0038079966,
0.026697367,
-0.047324017,
0.00007114124,
-0.016059812,
-0.0003695033,
0.01071344,
0.015908044,
-0.039100952,
0.042743385,
-0.0019919549,
-0.019991983,
0.005691299,
-0.008402428,
0.023386067,
-0.015507928,
-0.0029025627,
-0.029001482,
0.0022075344,
-0.0270147,
-0.010361614,
0.019467693,
0.0033113016,
0.018515695,
0.007353849,
-0.006981327,
-0.012934771,
0.007822949,
-0.00114947,
-0.014445553,
-0.017977608,
-0.013403872,
-0.025469428,
0.014818074,
-0.007926428,
-0.0074573266,
-0.021413082,
0.030326003,
0.016708275,
-0.021537257,
-0.0054257056,
-0.0007286588,
-0.015038827,
-0.018115578,
0.001434035,
-0.014024741,
-0.004221909,
-0.0026904324,
-0.015645899,
-0.003583794,
0.019357316,
-0.037252143,
0.018750245,
0.018695056,
0.0014840495,
0.01332109,
-0.019288331,
-0.17627162,
-0.0072779646,
-0.008581789,
-0.035706867,
0.020405896,
0.018736448,
0.014928451,
-0.0040080543,
-0.0063915015,
0.020930184,
0.023786182,
0.004128779,
-0.009837325,
-0.03156774,
-0.008002312,
0.0046668653,
-0.045088887,
0.034906637,
0.018998591,
0.008264457,
0.04039788,
-0.02853238,
0.0036803735,
-0.0130106555,
-0.00011317925,
0.02384137,
-0.009775238,
-0.022530647,
0.00047427494,
-0.019136563,
-0.01099628,
0.0013434916,
0.0153975515,
-0.012189728,
0.02218572,
-0.010554774,
-0.031650525,
0.008954311,
-0.008402428,
0.031788494,
0.028422004,
0.014010944,
-0.0039563156,
0.0015357885,
-0.020681838,
0.019881606,
0.031236611,
-0.00445646,
0.014183408,
0.013955756,
0.007974718,
-0.014279988,
0.004063243,
0.020226533,
-0.0051187202,
-0.0037286633,
0.0000056993836,
0.019233143,
-0.0076642833,
-0.022544444,
0.0068812985,
-0.043102108,
0.009526891,
-0.00388733,
0.01445935,
-0.016239174,
-0.015604508,
0.033140607,
-0.00848521,
0.022282299,
-0.023675805,
0.0105961645,
0.0038666343,
-0.0029025627,
0.025069311,
0.010361614,
-0.023524037,
0.007933326,
-0.0010830716,
-0.013293495,
-0.029470583,
0.020267924,
-0.035486113,
-0.011527468,
0.0066777915,
-0.0044633583,
-0.0018970998,
0.025069311,
0.0014806002,
0.020074764,
0.018087985,
-0.008112689,
-0.0050083436,
-0.006153502,
0.012789902,
0.027152672,
0.0047151553,
-0.0075539066,
-0.008650775,
0.0039563156,
0.018805433,
-0.0025714326,
-0.017218767,
0.00051092345,
0.0044633583,
0.023717197,
-0.02080601,
0.00535672,
0.05455369,
-0.020488678,
0.009319934,
0.0022575487,
0.019026186,
0.025469428,
-0.015535522,
0.015811464,
-0.010879005,
-0.016556507,
0.0047772424,
-0.036231156,
0.044150688,
-0.0020281721,
-0.0022075344,
0.0074021383,
-0.002616273,
-0.008174775,
-0.12671247,
-0.020143751,
0.02773215,
0.023524037,
-0.011230831,
0.037941996,
0.0019505635,
0.048482973,
-0.044592194,
0.034244377,
-0.011513671,
-0.038852602,
-0.012141439,
0.013017554,
-0.028808324,
-0.014293784,
0.0004622025,
-0.03327858,
-0.0035199823,
0.037334923,
0.016142596,
0.007871239,
0.029001482,
-0.027842527,
0.009416513,
-0.0058706617,
-0.016791059,
0.014928451,
0.0045288946,
0.010885904,
-0.0037079677,
-0.004252953,
0.0132245105,
0.0029594756,
-0.03203684,
-0.033250984,
0.009706252,
-0.026518006,
0.028863512,
0.008774949,
0.0022920414,
-0.006105212,
-0.0021350996,
-0.022641024,
0.032257594,
-0.025345253,
0.016515115,
0.016087405,
-0.00046306482,
-0.016335754,
-0.02678015,
-0.017743057,
-0.023620617,
-0.011189439,
0.019453896,
0.008705963,
0.028863512,
0.020240331,
-0.0040459963,
-0.026655978,
-0.010451295,
0.005494691,
-0.004152924,
0.008243761,
0.00095458614,
-0.02317911,
-0.012272511,
-0.030326003,
0.028946294,
-0.039956372,
-0.011286019,
0.024972731,
-0.016915232,
0.008664573,
-0.016197784,
-0.003361316,
-0.026324846,
-0.016942825,
0.003095722,
-0.03303023,
-0.020157548,
-0.018970998,
0.013735003,
-0.040453065,
-0.0019453897,
0.0066536465,
0.012500163,
-0.016115,
-0.017563695,
-0.016225377,
-0.016584102,
0.0237034,
-0.02351024,
0.006119009,
-0.015576914,
0.0053774156,
-0.008257558,
-0.0027628671,
0.012300105,
0.018460507,
-0.021854589,
-0.015259581,
-0.053256765,
-0.0077056745,
0.01512161,
0.001095144,
0.008705963,
-0.022916965,
0.0072986605,
0.016390942,
-0.008443818,
0.015908044,
-0.036865823,
-0.0076435874,
-0.017467115,
-0.009485499,
0.0029422294,
-0.010216745,
0.010630657,
0.002085085,
0.032257594,
0.013300395,
0.0039080256,
0.004190866,
0.008160979,
0.021551054,
-0.012113845,
0.007843645,
-0.025690181,
0.032533538,
-0.0068399073,
-0.0055705747,
-0.015618306,
-0.00336649,
-0.025165891,
-0.0011029048,
-0.001523716,
-0.005180807,
0.0118861925,
0.026724963,
0.014121321,
0.008126486,
-0.021288909,
-0.032202408,
0.011679236,
0.0035044607,
-0.0024110414,
0.019467693,
-0.03090548,
0.0036010405,
0.026421426,
0.001618571,
0.03802478,
0.014528335,
-0.0027318236,
-0.03901817,
-0.0037562577,
0.004390924,
0.013741901,
-0.011658541,
-0.006753675,
-0.011023874,
0.029525772,
0.009782136,
0.03261632,
0.007381443,
0.013755698,
-0.0030267364,
-0.019936794,
-0.020143751,
0.016059812,
-0.017894825,
-0.03954246,
-0.005660256,
0.015811464,
0.00007841705,
0.029774118,
0.0064018494,
-0.017687868,
0.004063243,
0.003019838,
0.028021889,
0.014666306,
0.0044909525,
-0.008809442,
0.027607976,
0.019274535,
-0.0017815492,
-0.012175932,
0.0037769533,
-0.020888794,
0.020819807,
0.0089957025,
-0.007988514,
-0.017411927,
0.013941959,
0.00036799425,
0.015163002,
-0.013831582,
0.0031129683,
0.0030491569,
0.007809153,
-0.004128779,
0.009175064,
0.0005273075,
-0.01147228,
0.0005760285,
0.024669196,
-0.008809442,
-0.031181423,
-0.013900568,
-0.0027266499,
-0.004042547,
-0.004442663,
0.027180266,
0.0061362553,
-0.015756276,
0.019053781,
-0.008630079,
-0.002000578,
-0.017743057,
-0.0026007514,
0.008919818,
0.018612273,
0.004866923,
0.02175801,
-0.010327121,
0.009554485,
0.00502559,
-0.013610829,
0.0077953557,
-0.02251685,
0.020847403,
-0.0041736197,
-0.034823854,
-0.021413082,
0.005887908,
0.014066133,
0.022544444,
0.0099546,
-0.015273378,
0.088577315,
0.018874418,
-0.015245784,
0.00052773865,
-0.020599054,
0.014900857,
-0.0047186045,
0.01720497,
-0.0035355042,
-0.023013545,
-0.0018332882,
-0.019081375,
0.0125553515,
-0.033113014,
-0.01223112,
0.0050462857,
0.0074918196,
0.0007441805,
-0.018184563,
-0.008416224,
0.010658252,
-0.037417706,
0.008616283,
-0.0025783312,
-0.027428614,
-0.013231409,
0.030795103,
-0.012341497,
-0.0049186624,
-0.019922998,
0.026338644,
-0.0046047787,
-0.025593601,
-0.0034061566,
0.004459909,
0.014004046,
0.012796801,
-0.009837325,
0.017991405,
0.017991405,
0.016501319,
-0.0015676942,
-0.020695634,
-0.031926464,
0.024282878,
-0.0028732438,
-0.0033216493,
-0.002843925,
-0.025372848
] |
We developed a novel mouse model of malignant pleural effusion (MPE) by injecting Lewis lung cancer (LLC) cells directly into the pleural space of syngeneic C57B/6 mice. The pleural effusions in this model share common cellular and biochemical features with human MPEs. Implantation and growth of pleural tumors triggers a host inflammatory response characterized by a mixed inflammatory cell influx into the pleural fluid. LLC cells exhibited high basal nuclear factor (NF)-κB activity in vitro and in vivo, which we used to drive expression of a NF-κB–dependent green fluorescent protein-fire
|
[
-0.029716605,
0.007056362,
-0.010165156,
-0.04670513,
-0.0245375,
0.0065803905,
-0.02514994,
0.0059646233,
-0.0390097,
0.0024447632,
-0.0052223736,
0.014312433,
0.02172827,
0.023046345,
0.0013313891,
0.011256895,
0.028278705,
0.0003430407,
-0.010611171,
-0.006230901,
-0.01573702,
-0.0023266023,
0.006337412,
-0.026614469,
0.00795505,
0.0059812656,
0.0062009445,
-0.03240601,
-0.012395232,
-0.001063447,
0.0049161543,
0.017720789,
0.002146865,
0.013467001,
-0.0063274265,
-0.0045899637,
0.017507767,
-0.0059812656,
0.03024916,
-0.012341977,
0.015856843,
0.007056362,
-0.0015810245,
0.00601455,
-0.008327839,
-0.0183066,
-0.005472009,
-0.024857035,
0.0059246817,
-0.0043336716,
0.033923794,
-0.01560388,
0.00058539514,
0.0044668103,
-0.017161606,
-0.0032153046,
0.0025895517,
0.025775693,
-0.0062774997,
-0.03794459,
-0.019345084,
0.0031670418,
-0.028118938,
0.025536044,
-0.0035181956,
0.01519115,
-0.0052956003,
0.025655868,
0.008001649,
-0.01161637,
0.027746148,
0.01943828,
0.006780099,
-0.006324098,
0.011882648,
0.009912192,
-0.028544983,
0.022833323,
-0.021235656,
0.0068899384,
0.0047197742,
-0.026854118,
-0.014605339,
0.024324479,
0.021581817,
0.011762823,
0.0018506309,
0.010118557,
0.0012797978,
0.0031637133,
0.0126215685,
0.019251887,
0.009579345,
-0.0039309263,
-0.0023116244,
-0.007469093,
0.0023182812,
0.004999366,
0.023831865,
-0.060285296,
0.003724561,
-0.0055951625,
-0.02100932,
-0.009419578,
-0.030675204,
-0.002885786,
0.0032818741,
-0.012581627,
0.031500667,
-0.008554175,
-0.021595132,
0.018226717,
0.009759082,
-0.01950485,
0.03839726,
-0.012861218,
0.0071761874,
0.010624485,
0.0031137862,
-0.008168072,
0.023112915,
0.013633424,
0.016522538,
-0.0015319296,
0.02700057,
-0.00780194,
-0.01416598,
-0.016882014,
-0.019251887,
0.010404806,
0.008767197,
0.0015252726,
0.029263932,
0.007948393,
-0.014871616,
-0.005328885,
-0.0059280097,
0.0020370253,
-0.023459075,
-0.008221327,
-0.007063019,
0.03480251,
-0.0064605656,
0.0052956003,
-0.003774488,
0.03530844,
0.020849554,
-0.005408768,
0.014219236,
0.0021435365,
-0.00018899485,
-0.024697268,
0.020450136,
-0.005618462,
-0.014898244,
0.0038976416,
-0.008813796,
0.027559754,
-0.011742852,
-0.014805047,
-0.003667977,
0.0016201341,
0.018825842,
0.025189882,
0.012741393,
0.031261016,
0.014032841,
0.0006061981,
-0.010484689,
0.003288531,
0.0014195936,
0.02094275,
-0.01867939,
0.031234387,
-0.023565587,
-0.0046698474,
-0.012375262,
0.019078806,
-0.0022816681,
-0.024550814,
0.001985434,
0.039409116,
0.012082356,
-0.003251918,
-0.0061177327,
-0.009299753,
0.018666076,
-0.03986179,
-0.00008295178,
-0.02747987,
0.022886578,
0.016495911,
-0.007036391,
-0.030142648,
-0.6407709,
-0.016695619,
0.017081723,
0.0050526215,
-0.0058481265,
0.02870475,
-0.0019355069,
-0.02514994,
-0.026814176,
0.01440563,
-0.026468014,
0.036772966,
0.010165156,
-0.0039209407,
-0.0061010905,
-0.016815444,
-0.023871806,
-0.030834971,
0.014631966,
0.0106511125,
0.0018240031,
0.008008305,
0.008054904,
0.035015535,
0.010737653,
0.03411019,
0.01019844,
0.007921765,
0.0034349838,
0.040953528,
-0.00636404,
0.015803589,
-0.022913206,
-0.005155804,
0.05160464,
0.005951309,
-0.014112724,
0.023272682,
0.016842073,
0.03754517,
-0.009945476,
0.0016084844,
0.0066003613,
-0.00884708,
-0.033444494,
0.02425791,
-0.001309754,
0.009306409,
0.0058048563,
-0.003844386,
-0.00007587878,
0.022247512,
-0.015444114,
0.01721486,
0.014365688,
-0.00041106637,
0.022859951,
-0.0070297346,
0.0021385436,
-0.0018955652,
0.008853737,
-0.0028242092,
-0.0044002407,
-0.033524375,
-0.006114404,
0.011496545,
0.008074875,
-0.00850092,
-0.0053222277,
0.00040669777,
0.013160781,
0.04212515,
-0.014445571,
0.01512458,
0.01765422,
0.03698599,
-0.0014570389,
0.008514233,
-0.00051840965,
-0.010191783,
-0.012854561,
-0.0057981997,
-0.01793381,
0.017600963,
0.01745451,
0.010917391,
-0.015390858,
0.014046155,
0.008753884,
0.004104007,
0.025789008,
0.008667343,
-0.02087618,
-0.04513409,
-0.03706587,
0.023059659,
-0.003970868,
0.005525265,
0.014352375,
-0.024817092,
-0.028065681,
-0.026321562,
0.0015976669,
-0.016402714,
0.02388512,
0.0057416153,
-0.03538832,
0.0064339377,
0.03490902,
-0.02569581,
0.008680657,
-0.015470741,
0.0019454923,
-0.031607177,
0.0038577,
-0.02443099,
0.015404171,
0.018772585,
-0.0068766247,
-0.030914854,
0.025003487,
0.0011233595,
0.02528308,
-0.007915108,
-0.009652571,
0.012934445,
-0.00394424,
-0.015470741,
-0.023552272,
0.0061543463,
0.010571229,
-0.011676283,
0.026374819,
-0.012841248,
0.025828948,
-0.0076155458,
0.023765296,
0.005824827,
0.012461802,
-0.027666265,
-0.011103785,
0.005708331,
0.016748875,
-0.002667771,
0.0017241489,
0.008381094,
-0.012961073,
0.006597033,
0.009932162,
-0.0067767706,
-0.008687314,
-0.008048247,
0.0041173208,
0.016788816,
0.02737336,
-0.00068025663,
-0.01385976,
-0.019225258,
-0.0084876055,
-0.02323274,
-0.0140195275,
-0.0041206493,
-0.017880555,
-0.004949439,
-0.004450168,
-0.016961897,
0.008307868,
0.0021784855,
0.021435365,
-0.024617385,
-0.007828568,
-0.011722881,
-0.009519432,
0.022460533,
0.011023901,
-0.02063653,
0.0012822942,
-0.03658657,
-0.0061643315,
-0.012102326,
0.005442053,
-0.009865593,
0.019691244,
0.027133709,
0.02039688,
0.018359855,
0.031261016,
0.03448298,
0.0008911986,
0.022247512,
-0.011123756,
-0.002731012,
0.0061177327,
0.020609902,
0.016842073,
-0.015803589,
0.011649654,
0.013353833,
0.023991631,
0.02360553,
-0.012974387,
-0.021648386,
0.0332581,
-0.0108441645,
0.030302417,
-0.0313409,
-0.015097952,
-0.010065301,
0.008926963,
0.014272491,
0.00093530084,
0.0067967414,
-0.003990839,
-0.01536423,
-0.013074241,
0.010491346,
0.008727255,
-0.01584353,
0.0055219363,
-0.017494453,
-0.0143390605,
-0.0063473973,
0.01656248,
0.0014245863,
0.00040940216,
0.01137672,
0.014072782,
0.016455969,
0.011769479,
0.005718316,
0.0027276834,
0.0072960122,
0.023432449,
0.009306409,
0.012135612,
0.0008441839,
0.007515691,
-0.005894725,
0.03062195,
0.011623027,
0.00298564,
0.027133709,
0.008966905,
-0.0010726004,
-0.0001098396,
-0.005082578,
-0.0016426013,
-0.0033035092,
-0.031047994,
0.008101502,
-0.011416662,
0.005119191,
0.0028907785,
0.016642364,
-0.0022849964,
-0.01724149,
0.008141444,
0.010644455,
0.043855958,
0.0016792145,
0.006513821,
-0.024590757,
0.0025229824,
-0.0064672227,
-0.0030805015,
-0.0037711596,
-0.017640905,
-0.017121663,
-0.004123978,
0.00453338,
-0.032352757,
0.0044335257,
0.014006213,
-0.03877005,
0.017401256,
0.017547708,
0.017427884,
0.0049527674,
0.030355671,
-0.019291827,
-0.024044886,
-0.024071515,
0.019797755,
0.026720978,
-0.0064871935,
-0.021461992,
-0.031660434,
0.010451404,
-0.0103315795,
0.0018972295,
0.00954606,
0.015856843,
-0.0074025234,
0.015031382,
0.0005329717,
-0.0057549295,
0.0144722,
0.0046565332,
0.015151208,
-0.0011108777,
-0.0055152792,
-0.0077353707,
0.004070722,
-0.0040041525,
0.029796489,
0.012401889,
-0.0031853484,
-0.029743232,
0.0060178787,
-0.011915932,
-0.013273949,
-0.020157231,
-0.004210518,
-0.0077154,
-0.007435808,
0.0035248527,
0.007675458,
0.0101119,
0.037199013,
-0.012654853,
-0.0019671274,
-0.03829075,
-0.0019321784,
-0.014112724,
0.033764027,
0.032539148,
0.005398783,
-0.001245681,
-0.002541289,
-0.020689787,
-0.004809643,
-0.022540417,
0.025815634,
0.004759716,
-0.007994992,
0.018532936,
0.013673366,
0.008693971,
0.012774678,
0.012708109,
0.012242123,
-0.022593673,
-0.019038863,
-0.00017588898,
0.007076333,
-0.00250634,
0.051444873,
0.029823115,
0.011143726,
0.008381094,
0.019864324,
0.017614277,
-0.011955874,
0.004217175,
-0.017867241,
0.017494453,
0.020889495,
-0.0015552288,
-0.0024797122,
-0.017960439,
0.0049793953,
0.0018106891,
0.018745959,
0.004513409,
0.01170291,
0.017960439,
0.0046731755,
-0.0029323844,
0.0038244152,
-0.0017291416,
-0.008427693,
-0.008161415,
0.01717492,
-0.030941483,
0.051791035,
-0.03658657,
-0.008940278,
-0.017254803,
0.03586762,
0.013913016,
-0.023565587,
-0.030941483,
-0.016269574,
-0.010950675,
-0.0058048563,
-0.021355482,
0.0077154,
-0.015204463,
-0.012701452,
-0.0058281557,
-0.004802986,
0.0058913967,
-0.03698599,
-0.020077348,
0.0036513347,
-0.026601154,
-0.02111583,
-0.003681291,
0.017228175,
-0.0003723729,
0.011509859,
0.005635104,
-0.0048895264,
0.009539403,
-0.0026444716,
0.0061543463,
-0.006294142,
-0.033684146,
-0.0060245357,
0.0051924177,
-0.0022650256,
-0.015856843,
-0.020649845,
0.0006910741,
0.019864324,
-0.024377733,
0.008753884,
-0.0066869017,
-0.011183668,
0.015590566,
-0.0053322134,
0.009173271,
-0.0030122679,
0.010444747,
0.0152310915,
-0.026894059,
-0.029210677,
-0.014831674,
-0.015790274,
-0.0029939613,
0.016269574,
0.009432891,
-0.035068788,
0.008534204,
0.0120490715,
-0.018359855,
0.0057482724,
-0.01553731,
0.017907184,
0.017867241,
-0.016642364,
-0.0023698725,
0.021981234,
0.0049594245,
0.013480315,
-0.0042371457,
0.04058074,
-0.015630508,
-0.011809421,
0.0051591326,
-0.008374438,
-0.010644455,
-0.030595321,
-0.007662144,
-0.01168294,
0.044228744,
-0.0048196283,
-0.011256895,
-0.02676092,
-0.018745959,
-0.032113105,
0.011210296,
-0.0076088887,
-0.008101502,
-0.01721486,
0.023738667,
0.009013504,
-0.008480948,
0.02142205,
-0.02870475,
-0.015377544,
0.032512523,
-0.01614975,
0.0021535219,
-0.028971026,
0.0121755535,
-0.008094845,
-0.023565587,
-0.009838966,
-0.028731376,
-0.01824003,
-0.010644455,
0.044495024,
0.014072782,
0.02323274,
-0.013427059,
0.03144741,
0.012981043,
0.0039941673,
0.002429785,
0.0067967414,
0.014205921,
-0.0009561038,
0.02857161,
0.015004755,
-0.0037212325,
0.020130603,
-0.0011624692,
0.0077154,
0.025815634,
-0.017667534,
0.0023748653,
-0.009978761,
-0.013886388,
-0.042817473,
-0.0034066918,
0.008181386,
-0.003534838,
-0.046518736,
-0.004783015,
0.022034489,
0.014991441,
-0.000605782,
-0.006440595,
0.012954416,
-0.0318202,
0.021981234,
-0.012368605,
-0.015097952,
0.013120839,
-0.015617194,
0.0059379954,
-0.010125214,
-0.0077819694,
-0.009372979,
0.0054520383,
0.02152856,
0.00038006998,
0.007063019,
-0.0047630444,
-0.028305331,
0.00049178186,
-0.02094275,
-0.036187157,
-0.036826223,
-0.014032841,
-0.0063906675,
-0.03408356,
0.0041306345,
0.009120015,
-0.0013239001,
0.003175363,
-0.0016742218,
0.0021684999,
0.016309517,
0.007915108,
0.01741457,
-0.0240582,
0.022899892,
0.035494834,
-0.020663159,
-0.029956255,
0.0031437424,
0.0027776104,
0.023272682,
0.029503582,
0.007056362,
-0.018759273,
0.017534394,
0.006720186,
0.008294554,
-0.0046265773,
-0.018120205,
0.037119128,
-0.01553731,
-0.005092563,
-0.015244405,
-0.029982882,
-0.021568503,
-0.0035082102,
-0.04036772,
0.004703132,
-0.009026818,
-0.005415425,
-0.011862677,
0.021062575,
0.008274583,
0.0041306345,
-0.01662905,
-0.01741457,
0.0046731755,
-0.02401826,
-0.011556458,
0.02299309,
0.009799024,
0.014765105,
0.01178945,
-0.0032968523,
0.011915932,
0.0036513347,
0.0044734674,
-0.003844386,
0.0016242947,
0.043110378,
-0.0055485643,
0.02111583,
0.015337602,
-0.0022866607,
0.0117295375,
-0.029689977,
-0.028837888,
-0.015244405,
-0.0027376688,
0.00621093,
0.030116022,
0.008840424,
-0.0322995,
0.005781557,
-0.028624866,
0.004696475,
-0.015217777,
-0.010165156,
0.016668992,
-0.042684335,
0.009532746,
0.0060744626,
0.009772396,
0.035814367,
-0.0027626324,
-0.004569993,
-0.01440563,
0.037039243,
-0.016948583,
-0.001358849,
-0.0034682686,
-0.0018672732,
-0.02381855,
0.006084448,
-0.0040174667,
0.0045267227,
-0.01793381,
-0.016242947,
-0.005139162,
-0.02388512,
-0.017361313,
0.005605148,
0.006780099,
-0.009745768,
0.019544791,
0.008274583,
0.025176568,
-0.011882648,
0.008227984,
0.018146833,
-0.031607177,
-0.0021784855,
0.010644455,
0.0022966461,
-0.03349775,
0.010464719,
-0.0047364165,
0.0023249383,
-0.017600963,
-0.011523172,
-0.011489888,
-0.0116696255,
-0.009745768,
0.005112534,
-0.019065492,
-0.011383377,
-0.014219236,
0.01680213,
0.014032841,
-0.0037611742,
-0.0013155788,
-0.01043809,
0.0007759502,
0.028278705,
-0.033071704,
0.0018423096,
0.01002536,
-0.02425791,
-0.024324479,
0.004646548,
-0.024044886,
0.040128067,
-0.006610347,
-0.00786851,
-0.035734482,
0.015697077,
-0.046012808,
-0.01769416,
-0.0075023775,
0.018652761,
-0.01902555,
0.02094275,
-0.008141444,
0.0075822608,
0.006597033,
-0.0009827316,
-0.001358849,
-0.038929816,
0.012415203,
-0.033524375,
0.009812337,
0.03107462,
-0.01360014,
-0.021874722,
0.031287644,
0.0005429571,
-0.01717492,
0.0245375,
-0.00882711,
-0.010298295,
0.00020594925,
0.008507576,
-0.010750967,
0.023392506,
0.01146326,
-0.0108441645,
-0.01392633,
0.024364421,
0.017561022,
0.0026178437,
-0.013560198,
0.019464908,
0.007315983,
-0.008600773,
-0.011929247,
-0.0039841817,
0.01209567,
-0.0049161543,
0.01457871,
0.0042438027,
-0.011090471,
0.004104007,
0.008221327,
0.0029956254,
-0.027932543,
-0.005075921,
-0.007056362,
0.0020303684,
0.0072960122,
0.0049261395,
-0.014498827,
0.018732645,
0.0047630444,
-0.032352757,
-0.021182401,
-0.016003298,
0.013227351,
-0.012854561,
0.0017491124,
0.010165156,
-0.01710835,
-0.022007862,
-0.017441196,
-0.022034489,
-0.031021366,
-0.0025512744,
0.021209028,
-0.03158055,
0.006097762,
-0.006863311,
0.002471391,
0.002386515,
-0.00780194,
-0.007861853,
0.012062385,
0.030941483,
0.19129398,
-0.011802765,
0.0021069231,
0.01943828,
0.005162461,
-0.020250428,
0.0009211548,
-0.010717683,
-0.0016867035,
0.012681481,
0.026920687,
-0.013713308,
-0.023991631,
-0.0013272285,
0.008068218,
-0.0026977272,
-0.042364802,
0.0050393078,
-0.028278705,
-0.011822735,
-0.0030455526,
-0.008720598,
0.038849935,
-0.00077678234,
0.012255437,
-0.008121474,
-0.011489888,
0.021648386,
0.0040307804,
0.0076155458,
-0.02087618,
0.009426234,
0.011489888,
-0.010937361,
-0.0024680626,
-0.0071495594,
0.0008425197,
-0.019118747,
0.0034882394,
0.011390034,
0.0042138463,
0.022460533,
-0.012914474,
0.020583276,
-0.013047613,
0.033178218,
-0.016003298,
-0.00030538737,
0.021035947,
0.00043145329,
-0.044122234,
0.019118747,
0.015404171,
0.025123311,
0.021541875,
-0.0067601283,
0.016961897,
0.027666265,
0.014205921,
0.018945666,
-0.01957142,
0.0061709885,
-0.041113295,
0.020530019,
-0.0054220823,
0.026121855,
-0.010571229,
-0.012075699,
0.0033900496,
-0.009765739,
-0.007116275,
-0.009759082,
0.0007443297,
0.002035361,
-0.010378178,
-0.017201547,
0.024457617,
0.023352565,
0.014991441,
0.022021176,
0.0024048216,
-0.0040174667,
-0.04465479,
-0.006816712,
-0.019451594,
-0.03360426,
0.011569771,
0.0111570405,
-0.014964813,
-0.018759273,
-0.0011108777,
0.0032286185,
-0.01765422,
-0.0032802098,
0.021035947,
0.014485513,
0.0076488303,
-0.0100786155,
-0.02381855,
0.0046099345,
-0.031021366,
0.06332087,
0.011716224,
-0.018639447,
-0.0053255563,
0.020849554,
0.009925506,
0.0032269543,
0.011416662,
0.0011599727,
-0.0071761874,
-0.027040513,
0.004866227,
-0.016642364,
-0.009639257,
0.01662905,
0.0025928803,
-0.04225829,
0.013646739,
-0.0096326005,
-0.0082346415,
-0.02275344,
0.018373169,
0.003112122,
-0.003844386,
0.011623027,
-0.005914696,
0.012162239,
-0.019038863,
-0.015803589,
-0.013247321,
0.0027376688,
-0.00505595,
0.0059612948,
0.014046155,
-0.00274599,
-0.018519621,
0.005025994,
-0.008154758,
0.0053954544,
-0.018093579,
-0.0062009445,
0.003731218,
0.01752108,
0.009219869,
-0.013467001,
0.02059659,
0.010963989,
-0.005851455,
-0.008354466,
-0.029077537,
-0.021302225,
0.0053754835,
-0.02586889,
0.0380511,
-0.034190074,
-0.011809421,
-0.019012237,
-0.012568313,
0.025789008,
-0.034695998,
0.017494453,
0.016349457,
-0.007189501,
0.008973562,
0.0018672732,
-0.16807456,
-0.0009394614,
0.02905091,
-0.0018190104,
-0.0034183415,
0.019917581,
0.0025296393,
-0.020077348,
-0.008088189,
0.0051924177,
0.033790655,
0.015324288,
-0.01806695,
0.0011291844,
-0.0033134946,
0.02580232,
-0.02063653,
0.033071704,
0.014152666,
0.0143390605,
0.04215178,
-0.01710835,
0.0010168484,
-0.0021135802,
-0.010032017,
0.007189501,
0.0012972723,
-0.016362771,
-0.017667534,
-0.013147467,
-0.0054254103,
-0.005934667,
0.030808343,
-0.0018406454,
0.01618969,
-0.0024813765,
0.008547518,
-0.018333228,
0.019278513,
0.028039055,
0.037199013,
0.024004946,
0.007788626,
0.019491537,
-0.014978128,
0.018945666,
-0.004783015,
0.007988335,
0.024950232,
0.0025263107,
0.031394154,
-0.02809231,
-0.010677741,
0.020263743,
0.002857494,
0.01368668,
0.008494263,
-0.0076022316,
-0.007568947,
-0.00048678913,
-0.015643822,
-0.015710391,
0.01131015,
-0.0022284125,
-0.00022446387,
-0.0409269,
-0.0073892092,
0.00891365,
-0.029610094,
-0.018852469,
-0.020090662,
-0.015683763,
0.031234387,
-0.011596399,
0.030568693,
0.0049394537,
0.0109706465,
0.019558106,
0.0035082102,
-0.0022234197,
-0.011935903,
0.01895898,
-0.013726622,
-0.013673366,
-0.03349775,
-0.0005816506,
-0.0046864897,
0.024777152,
-0.023632156,
-0.006187631,
-0.007835225,
-0.02976986,
0.011756166,
-0.026268307,
0.012348634,
0.02833196,
-0.025482787,
-0.014365688,
0.0021984563,
0.029130794,
0.024071515,
-0.031287644,
-0.030408926,
0.016708933,
0.026068598,
-0.022673557,
-0.015683763,
-0.013220694,
0.040767133,
-0.0322995,
-0.0040807077,
0.00075847574,
0.0061709885,
0.017973753,
0.0040673935,
0.014126038,
0.013713308,
-0.0029673334,
0.026294934,
-0.03706587,
0.06481202,
-0.018053636,
0.0030372313,
0.03158055,
0.0033184872,
0.0069032526,
-0.12642871,
-0.034882393,
0.003484911,
0.02142205,
-0.026454702,
0.010278324,
-0.0073825526,
0.026494643,
-0.011010588,
0.028518355,
0.008201357,
-0.0073692384,
0.015377544,
0.0014636959,
0.026694352,
-0.007469093,
0.02593546,
0.007515691,
-0.028598238,
0.028864516,
-0.0005941324,
0.013739935,
0.0018772586,
-0.041246433,
0.029370444,
0.021848096,
-0.054586954,
0.029956255,
0.017268116,
-0.00032993485,
0.03442972,
-0.019691244,
0.0014462214,
0.004639891,
-0.02042351,
-0.018027008,
-0.020809611,
-0.00010879945,
0.040873647,
-0.006963165,
-0.004922811,
0.0025096685,
-0.0021601787,
0.0065005072,
-0.006830026,
-0.016296202,
-0.034722626,
0.00906676,
0.034136817,
-0.024777152,
-0.020316998,
-0.03528181,
-0.024830407,
0.013453687,
0.0056717177,
0.0019837697,
0.0055951625,
0.022567045,
-0.033417866,
-0.021834781,
-0.0010243375,
-0.01226875,
-0.011543144,
0.002260033,
0.0116030555,
-0.013134154,
-0.008421036,
-0.0045932923,
0.0062076016,
-0.019291827,
-0.017907184,
0.0011633012,
-0.012082356,
-0.01002536,
-0.022074431,
-0.013873074,
-0.0072627277,
-0.012754708,
0.0070497054,
-0.022606988,
-0.021914665,
-0.012368605,
0.020569962,
-0.025229823,
0.043403283,
0.029450327,
0.008867051,
-0.005541907,
0.0068899384,
0.010304951,
-0.028864516,
0.017747417,
-0.003415013,
-0.015856843,
-0.024510873,
0.00095527165,
-0.018626133,
-0.010963989,
0.029503582,
0.021648386,
-0.002083624,
-0.008973562,
-0.055971596,
0.016828759,
-0.009326381,
0.0016867035,
-0.00568836,
-0.014938186,
0.0048628985,
-0.0075023775,
0.029956255,
0.007362582,
-0.033098333,
0.019917581,
0.009625943,
0.012481772,
-0.0065171495,
-0.012861218,
0.016988525,
0.018453052,
-0.00031308446,
0.022593673,
0.00254961,
-0.013833133,
-0.0011982502,
0.00632077,
-0.016256262,
-0.012541685,
-0.0050592786,
0.034376465,
-0.016416028,
-0.018759273,
-0.027213592,
-0.02891777,
-0.0011008923,
0.0009769067,
0.0008391912,
-0.02953021,
-0.0028891144,
0.0337374,
0.025709122,
0.015497369,
-0.0011408341,
-0.044122234,
-0.008940278,
0.0029889685,
-0.0010834179,
-0.00788848,
-0.009739111,
0.01019844,
-0.0055152792,
0.015883472,
0.025828948,
-0.0015469077,
-0.0006540449,
-0.03240601,
-0.03453623,
0.037491918,
-0.0017033459,
-0.0117295375,
0.0036113928,
-0.012062385,
0.035627972,
0.006337412,
0.010810879,
0.009266468,
-0.003055538,
-0.0043270146,
-0.036559943,
0.0008042422,
-0.0060711345,
-0.031979967,
0.0015044697,
0.0077154,
0.01724149,
-0.00520906,
0.003934255,
-0.002105259,
-0.009372979,
0.0151645215,
-0.013360489,
0.021675015,
0.01139669,
-0.012787992,
-0.023738667,
-0.014698535,
0.031047994,
0.007056362,
-0.030142648,
0.027160337,
0.006483865,
0.007682115,
-0.0052057314,
0.019531477,
0.00923984,
0.0030372313,
-0.00260453,
-0.009945476,
0.013493628,
-0.0076554874,
0.016509226,
0.022247512,
0.0016966889,
-0.00858746,
0.012907817,
-0.031287644,
-0.013353833,
0.0046698474,
-0.05618462,
-0.03285868,
-0.01098396,
0.014379002,
0.0052756295,
0.00398751,
-0.03528181,
0.005062607,
-0.030781716,
0.01002536,
0.0022683542,
0.0018922368,
-0.008148101,
0.047450706,
0.027506499,
0.020157231,
0.011123756,
0.02251379,
0.0017341343,
0.014219236,
0.019118747,
-0.014858303,
0.016229633,
-0.010358207,
0.021741584,
0.00414062,
-0.031740315,
-0.009679198,
-0.0031087936,
0.002161843,
0.0050892346,
-0.0053421985,
0.009040132,
0.08094846,
-0.0006498843,
-0.01680213,
0.009326381,
-0.01943828,
0.022314081,
0.025176568,
0.03237938,
0.006557091,
-0.03315159,
0.011210296,
-0.017947124,
0.014685222,
-0.04295061,
-0.040287834,
0.007109618,
-0.011802765,
0.0016500903,
-0.020064034,
-0.010245039,
0.016615735,
0.0065071643,
0.0044035693,
0.014432258,
-0.02976986,
0.026468014,
0.026135167,
-0.0012506737,
-0.0028059024,
0.0028275375,
-0.0031387499,
-0.00040336928,
-0.030701833,
-0.0154308,
0.023751982,
-0.015031382,
0.004550022,
-0.03480251,
-0.0030821657,
0.0124950865,
-0.016362771,
0.020130603,
-0.027080454,
-0.03456286,
0.004746402,
-0.0016267911,
-0.011276865,
0.00011920093,
-0.019704558
] |
PURPOSE To estimate the maximum tolerated dose (MTD) of single-agent PF-04449913, and to evaluate safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity in patients with advanced tumors. EXPERIMENTAL DESIGN A 3+3 design was used in this open-label, multicenter, phase I study and dose escalation/de-escalation applied until identification of the MTD. PF-04449913 was orally administered once daily in continuous 28-day treatment cycles. The starting dose was 80 mg. RESULTS A total of 23 patients were enrolled; 19 were evaluable for
|
[
-0.01580677,
-0.015126479,
0.0008399431,
-0.02168929,
-0.017847644,
0.03662902,
-0.033134192,
0.0059025283,
-0.026424652,
0.021956071,
0.032814056,
0.0027161634,
0.028732307,
-0.0014097706,
-0.022142818,
0.01007765,
0.018688004,
-0.023823537,
-0.03273402,
0.00037036696,
-0.017154014,
0.012331949,
-0.009404028,
-0.023730164,
-0.0030046203,
0.002162593,
0.014499544,
-0.029612685,
-0.007956741,
0.001715735,
0.0051422026,
-0.0057824766,
0.0062760217,
-0.016807199,
0.01049783,
-0.005288932,
0.0069162957,
-0.0035815341,
0.0056757643,
-0.026998231,
0.009837547,
-0.009677478,
0.019901859,
-0.0003107581,
-0.014312797,
-0.008456956,
0.00440522,
-0.026704771,
-0.019795146,
0.011818396,
-0.0042418167,
0.009470724,
0.0072697806,
0.016313653,
0.012305271,
-0.00068696094,
0.020235334,
0.031426795,
-0.009437376,
-0.017941019,
-0.0075165527,
-0.009577435,
-0.034628164,
0.03260063,
-0.008597015,
0.016700488,
-0.008096801,
0.01104473,
-0.007870038,
0.0037416026,
0.019888518,
0.01778095,
-0.0059425454,
-0.0082502,
0.04423228,
-0.014726308,
-0.026144532,
0.009023866,
0.009310654,
-0.005272258,
0.041457757,
-0.023490062,
-0.012338619,
0.02615787,
0.017500829,
0.024783948,
0.008690389,
0.010944688,
-0.0064861113,
0.0025627643,
0.02310323,
0.013425751,
-0.0007173906,
0.021942733,
-0.025410885,
0.006316039,
0.013585819,
0.031026622,
0.006246009,
-0.05666427,
-0.020328708,
0.012438661,
0.0048087263,
0.0040183878,
-0.059172012,
0.0032430557,
-0.016273636,
-0.010757942,
0.01834119,
-0.017180692,
-0.010577864,
0.042604916,
0.0077166385,
-0.016460383,
-0.010531178,
-0.00075448985,
0.00895717,
0.0043752072,
0.0071964157,
-0.012572052,
0.0071897465,
0.004548615,
0.003191367,
-0.017554186,
0.035001658,
0.0064861113,
0.00004415954,
-0.03865656,
0.008930492,
0.019061498,
0.014112712,
0.014806342,
0.023156585,
-0.018914768,
-0.045699574,
0.012158541,
-0.030679807,
-0.018007712,
-0.028625594,
-0.025544275,
0.005248915,
0.024397116,
-0.0030262962,
-0.015313226,
-0.0127788065,
-0.0036448946,
0.019795146,
0.014152729,
-0.0047220225,
-0.02730503,
-0.0044685807,
-0.011391546,
0.0055090263,
0.013385734,
-0.009950929,
-0.018741362,
-0.016113568,
0.015513311,
-0.03668238,
-0.003314753,
0.0046586622,
-0.016967267,
0.013659184,
0.0074765356,
0.014152729,
0.017927678,
0.0068429313,
-0.011604971,
-0.00881711,
0.0053256145,
-0.005065503,
0.034894947,
-0.0033164206,
0.027398402,
0.0038816626,
-0.0043885466,
0.0066695237,
0.005499022,
-0.007303128,
0.00965747,
-0.0006769566,
0.031586863,
0.0193016,
0.019021481,
-0.027478436,
-0.003681577,
0.0060559274,
-0.0028228757,
-0.020435419,
-0.0062093264,
-0.0022576337,
0.007069695,
-0.014246102,
-0.017007284,
-0.6308836,
-0.036789093,
-0.006902957,
-0.02546424,
0.0045419456,
0.04257824,
0.00406174,
-0.009804199,
-0.018808056,
0.019088177,
-0.003528178,
0.034094606,
0.020048587,
-0.02713162,
-0.010984705,
-0.01987518,
-0.015193175,
-0.030332992,
0.009590775,
-0.012498687,
-0.034227993,
0.02308989,
-0.014819681,
0.0067062057,
-0.007683291,
-0.010717924,
0.037482724,
0.00005319987,
-0.012278592,
0.026691433,
0.0045686234,
0.020968981,
-0.0007753321,
-0.006462768,
0.038709912,
-0.045192692,
0.0082502,
0.009397359,
0.006572815,
0.019955214,
-0.0033847832,
0.013519124,
0.036709055,
-0.0041451086,
-0.043325223,
0.0077499864,
0.028492205,
-0.009223951,
0.002544423,
0.0024410456,
0.007830021,
0.011038061,
-0.004141774,
-0.014486205,
0.01413939,
0.0038883323,
0.024463812,
0.009110569,
0.004802057,
-0.017901001,
0.003651564,
-0.011411554,
-0.004421894,
-0.022129478,
-0.004185126,
0.028305458,
0.009303985,
0.020968981,
0.015606685,
-0.0057724724,
0.039963786,
0.015233192,
-0.0016798862,
-0.006149301,
0.048634164,
0.010544516,
0.008370252,
-0.0028712298,
-0.006476107,
0.022756414,
0.009950929,
-0.001101305,
-0.04089752,
0.004351864,
0.042044677,
-0.0060225795,
-0.023556758,
-0.000096499665,
0.022729736,
0.015886804,
0.0015473295,
-0.0016573765,
-0.0050121467,
-0.043165155,
-0.0142861195,
0.009984276,
0.009757513,
-0.0063860686,
-0.0053356187,
-0.054503344,
-0.028465526,
-0.025037391,
0.021075694,
-0.0075965873,
0.020235334,
0.0025994468,
-0.017327422,
-0.012071838,
0.02966604,
-0.026651416,
0.003958362,
0.0062793563,
-0.01903482,
-0.00021186158,
0.010431135,
-0.02645133,
-0.006189318,
0.016607113,
-0.019928535,
-0.03107998,
0.024650559,
0.001182173,
0.026851501,
-0.005585726,
0.016660469,
0.018287834,
0.0028712298,
-0.016020196,
0.0061526354,
-0.002789528,
-0.004858748,
0.0045686234,
0.031320084,
-0.011978464,
0.02365013,
0.000603175,
0.009670809,
-0.010297745,
-0.003988375,
-0.017180692,
-0.037295975,
0.01091134,
0.01624696,
0.016460383,
-0.00045394443,
-0.02517078,
0.00027615996,
0.004251821,
-0.005819159,
-0.0059525496,
0.014913054,
-0.00909723,
0.01161831,
0.023049872,
0.0066094976,
-0.009344002,
0.01623362,
-0.042178065,
-0.0038449802,
-0.014672952,
-0.005512361,
-0.0040383963,
-0.0078500295,
-0.021329137,
-0.025504258,
-0.026504686,
-0.0013497449,
-0.0009295648,
-0.001031275,
-0.041751217,
-0.008830449,
-0.026931535,
-0.0165004,
0.0136458445,
-0.001982516,
0.0013630838,
0.009910912,
-0.021862699,
0.010617881,
-0.010171023,
0.0024510499,
0.016206942,
0.014312797,
0.031026622,
0.030306315,
0.008403599,
-0.008130149,
0.018021053,
-0.004785383,
0.024837306,
0.00057649694,
0.030599773,
-0.011871751,
0.025851073,
0.006526129,
-0.0053823055,
0.0103310915,
-0.014192746,
0.012965553,
0.027318368,
0.020742217,
0.009143917,
0.036175497,
0.0037582763,
0.024103658,
-0.009764182,
-0.017380778,
-0.0207022,
0.031666897,
0.018594632,
-0.009477393,
-0.0115382755,
-0.029212512,
-0.00867038,
-0.001812443,
0.024397116,
0.0045319414,
-0.018527936,
-0.02044876,
0.0027511783,
-0.0022609686,
0.01372588,
0.02337001,
0.004211804,
-0.012918867,
-0.00044935916,
0.018434564,
0.0020508785,
0.01623362,
-0.0072697806,
-0.015313226,
-0.007816682,
-0.016300315,
-0.0030613113,
0.04209803,
-0.014873037,
-0.010477821,
-0.016033534,
0.037829537,
0.002556095,
0.020128623,
0.023329994,
0.04575293,
-0.0044285636,
-0.009984276,
-0.00504216,
-0.0022409598,
0.037456043,
-0.00019206143,
0.007343145,
0.0070029995,
0.018768039,
-0.0053489576,
-0.026344618,
0.0024627214,
0.0062793563,
-0.0056757643,
0.039136764,
0.022969838,
0.013792574,
0.023530079,
0.019901859,
0.00853699,
0.0013213994,
0.0014672951,
0.008890475,
0.0019925202,
-0.0070029995,
-0.005849172,
0.00032784877,
-0.0015815108,
-0.005145537,
-0.0044018854,
-0.02603782,
-0.0039683664,
0.003528178,
0.0019908526,
0.020101944,
0.021742646,
0.010177692,
-0.014739647,
-0.027638504,
0.0056557558,
0.024303744,
0.00054898515,
-0.009724165,
-0.004155113,
0.010110998,
0.00011421559,
-0.0012747126,
0.0069229654,
0.010731263,
0.0070296777,
0.0021492539,
-0.0243571,
-0.031053301,
-0.0027878608,
-0.005522365,
-0.02084893,
-0.008023437,
0.012158541,
-0.012792146,
0.012525365,
-0.0064894464,
0.003406459,
0.0025410885,
-0.018861413,
-0.03454813,
-0.009277307,
-0.01819446,
0.0040484006,
-0.012605399,
0.007863368,
0.010737932,
0.0020758891,
0.012612069,
-0.0021775994,
0.026811484,
0.03438806,
-0.021382492,
0.007149729,
-0.0078500295,
0.0007182243,
0.0030563092,
0.013672523,
0.044125568,
0.01959506,
-0.0063894033,
0.0029479293,
0.018381206,
0.010157684,
-0.011945116,
0.015419939,
0.01707398,
-0.0119918035,
-0.00057733065,
-0.016753843,
0.0014772995,
-0.0016106899,
0.02926587,
-0.0024843975,
-0.030919911,
-0.0017090654,
0.0045786276,
0.005542374,
-0.0065127895,
0.020141961,
0.013779235,
-0.008223522,
-0.013172309,
0.00096374616,
0.02308989,
0.0041951304,
-0.0028862362,
0.010391117,
-0.0045386106,
0.014486205,
0.015620024,
-0.012965553,
-0.024557184,
-0.0015423273,
-0.009424036,
0.009370681,
-0.0014114379,
0.01791434,
-0.0072431024,
-0.013619167,
-0.001645705,
0.0029279208,
-0.012572052,
-0.019394973,
0.015486633,
-0.0016748841,
0.0026244575,
0.053516258,
-0.026211226,
-0.031400118,
-0.009297316,
0.0034514784,
0.011851743,
-0.0046253144,
-0.02633128,
-0.03985707,
-0.010404456,
0.0026144532,
-0.040630735,
0.02168929,
-0.0040484006,
-0.010577864,
-0.0007328139,
-0.011531606,
-0.0064560985,
-0.012045159,
-0.0042051347,
-0.015246531,
-0.020462098,
-0.010617881,
0.018154442,
0.029719396,
-0.00924396,
0.0030546417,
-0.012932206,
-0.0015056449,
0.029452616,
-0.01035777,
0.010431135,
-0.016286977,
-0.03302748,
-0.007223094,
0.017927678,
0.026984893,
-0.017154014,
-0.017740933,
0.013612498,
0.011371537,
-0.021742646,
0.0050021424,
-0.011785048,
-0.015499973,
-0.0051021855,
0.0004889594,
0.021062355,
-0.0069162957,
0.0004626982,
-0.008963839,
-0.0058458373,
-0.022209514,
-0.034308027,
-0.0035048346,
-0.0032530602,
0.020141961,
-0.00084786315,
-0.019995231,
0.0006602828,
-0.009197273,
-0.011458241,
-0.0070830337,
0.012018481,
0.036735736,
0.026771467,
-0.0044318982,
0.020262012,
0.0075632394,
0.006062597,
-0.01567338,
0.0048920955,
0.027371725,
-0.017300744,
-0.026904857,
0.007543231,
0.012485348,
-0.016407028,
-0.0100709805,
-0.00636606,
0.009484062,
0.033534363,
0.0066528497,
-0.015446616,
-0.015366582,
-0.007683291,
-0.026117854,
0.012445331,
0.010844645,
-0.022743074,
-0.009784191,
0.0012413651,
-0.004181791,
0.0048520784,
0.01751417,
-0.025477579,
-0.02379686,
-0.010424465,
-0.0077900034,
0.014873037,
-0.015740076,
0.002227621,
-0.008423608,
0.004085083,
-0.03569529,
-0.013032249,
-0.0047787135,
-0.0009979274,
0.03662902,
0.03035967,
0.04257824,
-0.015620024,
-0.0073564844,
0.008583677,
-0.004358534,
-0.006549472,
-0.03537515,
0.007870038,
-0.000022092796,
0.036895804,
0.018768039,
-0.013505785,
0.01846124,
-0.02379686,
0.014166067,
0.023890233,
0.00068821147,
-0.006349386,
-0.010851314,
-0.014152729,
-0.023516739,
0.019074837,
-0.0046953447,
-0.0040250574,
-0.018567953,
-0.008383591,
0.040257245,
0.013405742,
-0.0014814679,
0.004802057,
0.012125194,
-0.03542851,
-0.0062326696,
-0.0151531575,
0.010484491,
-0.0056024,
-0.01049783,
-0.0054123183,
-0.00064694375,
0.011218138,
0.010391117,
0.009837547,
0.033827823,
-0.014046016,
0.0006923799,
-0.0050288206,
-0.015660042,
-0.0028645603,
-0.019501686,
-0.021115711,
-0.008230192,
-0.0026828158,
-0.012358627,
-0.022863127,
0.0013589154,
0.0032864076,
0.0035515213,
0.0032030386,
-0.023183264,
-0.0002674062,
0.018447902,
-0.006379399,
0.025397545,
-0.0039550276,
0.018034391,
0.029799432,
-0.0008407768,
-0.021382492,
-0.018261155,
-0.020755557,
0.026011141,
0.019781807,
0.029586006,
-0.016527079,
0.00290291,
0.001101305,
0.008577007,
-0.020101944,
-0.0414044,
0.016900573,
0.0133457165,
0.010551186,
-0.014299458,
0.008330234,
-0.029025765,
0.049594577,
0.0017624216,
0.010411127,
0.02056881,
-0.0062059914,
-0.021622594,
0.011571623,
-0.0024093653,
-0.00812348,
0.010624551,
-0.0012672094,
-0.00055815576,
-0.026918197,
-0.013872609,
0.016740505,
-0.02589109,
0.037749503,
0.0049754647,
-0.0066261715,
0.0062093264,
-0.014312797,
-0.00854366,
-0.01610023,
-0.031586863,
0.03790957,
-0.0008945498,
0.006746223,
0.02002191,
-0.018514598,
-0.016860556,
-0.012798815,
-0.00812348,
-0.018034391,
-0.039963786,
0.002849554,
0.028518882,
0.0027795238,
-0.014632935,
0.0071897465,
-0.010511169,
-0.010924679,
-0.01231861,
-0.020555472,
0.036308885,
-0.04577961,
-0.011138104,
0.0032580623,
-0.0061693094,
0.01692725,
0.011644988,
-0.0033847832,
0.016473724,
0.019434992,
-0.017954357,
-0.0031313412,
0.01441951,
0.014099373,
-0.028625594,
-0.0008420273,
-0.022583006,
-0.036362242,
-0.007990089,
0.0021042346,
-0.05287598,
-0.028358813,
-0.0124786785,
-0.0010696248,
0.029746074,
-0.037402686,
0.028598916,
0.013339047,
0.037482724,
0.0015064786,
-0.00064402586,
0.016820539,
-0.00937735,
0.013592489,
0.027531793,
0.0071030427,
-0.0006619502,
-0.011118095,
-0.019088177,
-0.010437804,
-0.011364868,
0.008050115,
-0.017807627,
0.0024610541,
-0.02633128,
-0.000514387,
-0.028999088,
-0.0131523,
-0.010411127,
0.018021053,
0.011798387,
-0.020195317,
0.0057357904,
-0.014672952,
-0.0061759786,
-0.010664568,
-0.019288262,
-0.02056881,
-0.0008466126,
-0.003186365,
-0.014406171,
-0.021649273,
-0.012938876,
0.024250388,
0.0039283494,
-0.006422751,
0.0015765086,
-0.03596207,
-0.03006621,
-0.011558284,
-0.010711255,
0.022102801,
0.012051829,
0.018541275,
-0.011578293,
0.016727164,
0.003283073,
-0.0027611826,
-0.008143488,
-0.01860797,
0.02255633,
-0.039937105,
0.027691862,
-0.020355385,
-0.041377723,
-0.001543161,
0.026491348,
-0.015379921,
-0.023303315,
0.03417464,
-0.00511219,
-0.01372588,
-0.037936248,
-0.0032864076,
-0.012838833,
0.0066428455,
0.016700488,
-0.008990518,
0.008096801,
0.009924251,
-0.00004426375,
-0.006869609,
-0.030733164,
0.031053301,
-0.001182173,
-0.010411127,
-0.006326043,
-0.026051158,
0.0012922202,
-0.016847216,
-0.0077032996,
0.0049787993,
-0.002539421,
-0.00581249,
0.005418988,
-0.0073097977,
-0.0019941875,
-0.00035744478,
-0.011111426,
-0.007843359,
0.028065355,
0.009537418,
0.010451144,
0.01610023,
0.0000010014055,
0.022342904,
-0.0040383963,
-0.0007915891,
0.005819159,
-0.014819681,
0.025650987,
0.0067128753,
-0.009737505,
-0.022969838,
-0.0054223225,
-0.009117238,
-0.0038383107,
-0.02196941,
0.011658327,
-0.033134192,
0.0038283064,
-0.016993945,
-0.016593775,
0.012091846,
0.025450902,
-0.0136858625,
-0.0007832522,
0.023570096,
0.20776899,
0.008316896,
-0.00062735204,
0.027398402,
0.008963839,
0.023303315,
0.021062355,
0.0072831195,
-0.008183505,
0.023183264,
0.043405257,
-0.0073831626,
-0.0086370325,
0.005835833,
0.020208657,
0.006686197,
-0.024330422,
-0.030306315,
-0.009023866,
-0.016353672,
0.003037968,
0.012618738,
0.025664326,
0.0062326696,
0.017874323,
-0.00713639,
-0.00070738635,
-0.008723737,
-0.0066595194,
0.015073123,
-0.016153585,
-0.01679386,
0.019221567,
-0.012231906,
-0.0067228796,
-0.024330422,
-0.013805914,
-0.028038677,
-0.009257299,
-0.007216424,
-0.003651564,
0.00044685806,
-0.033667754,
-0.02127578,
0.0007207254,
0.023596775,
-0.009897573,
-0.00065903226,
-0.0033430986,
-0.006782905,
-0.03513505,
0.0030579765,
0.03959029,
0.006479442,
0.007149729,
-0.019568382,
0.04631317,
0.00297294,
-0.016620452,
0.009784191,
-0.019821825,
-0.0144728655,
-0.026117854,
0.029932821,
-0.0035048346,
0.013425751,
-0.017794289,
0.0032413884,
0.00018872667,
-0.001015435,
0.0022559664,
-0.0050988505,
-0.015780093,
0.0061659743,
0.0059592193,
-0.009984276,
0.021569239,
0.007843359,
0.022462955,
0.03662902,
-0.005418988,
-0.0069363043,
-0.0008737076,
0.009530749,
-0.036602344,
-0.015313226,
0.03246724,
0.012532035,
-0.012958884,
0.032067068,
-0.010877993,
-0.013025579,
-0.01104473,
-0.0009445713,
0.010271066,
0.017154014,
0.01958172,
0.02419703,
-0.008603686,
-0.017834306,
-0.02099566,
0.07389832,
-0.018941447,
0.010697915,
-0.01679386,
0.0006294363,
0.005122194,
0.0070029995,
-0.0009804199,
-0.027878609,
-0.004688675,
-0.041271012,
0.019715112,
-0.0059592193,
0.004688675,
0.012285262,
-0.007449858,
-0.0124786785,
0.014046016,
-0.036762413,
0.0049154386,
-0.042178065,
-0.005345623,
0.015740076,
-0.016420366,
0.0030179594,
-0.00012432408,
-0.0067628967,
0.014246102,
-0.0031896995,
-0.013652515,
-0.00009472808,
0.00087537494,
0.0003067981,
0.0119918035,
0.013979321,
-0.023823537,
0.0011621645,
-0.030306315,
0.017180692,
0.01791434,
-0.009870894,
0.00065903226,
0.01638035,
0.008103471,
-0.023289977,
-0.00011682087,
-0.007870038,
-0.0173541,
-0.009864225,
-0.0048053917,
-0.040070496,
-0.0041084266,
-0.015926821,
0.016580435,
0.0030396353,
-0.00657615,
-0.027798574,
0.017674237,
-0.0036015427,
-0.03438806,
-0.013885948,
0.02517078,
0.012285262,
-0.011358199,
0.024237048,
-0.16849884,
0.017274065,
0.037989605,
-0.0054456657,
0.03484159,
0.002857891,
0.039430223,
-0.013965982,
-0.013192317,
-0.008603686,
0.042071354,
0.016140247,
-0.015233192,
-0.023890233,
0.01133152,
0.0036749074,
-0.013385734,
0.020181978,
0.025797717,
0.027665183,
0.025504258,
0.008383591,
0.0018091082,
-0.00050563324,
-0.00021196579,
0.02266304,
-0.010751272,
-0.0107846195,
-0.0023960264,
0.0034648175,
-0.024730593,
0.014619595,
0.03180029,
0.0138325915,
0.02042208,
-0.012978893,
0.015353243,
-0.0050354903,
-0.023730164,
0.016113568,
0.001403101,
0.042071354,
0.02603782,
-0.022316225,
-0.021729307,
0.011418224,
0.01834119,
-0.004518602,
0.0014889711,
-0.008903814,
0.025931107,
-0.027345046,
0.0038683235,
0.0025861077,
-0.000012375092,
0.0076699518,
0.017714255,
-0.002587775,
0.01776761,
-0.019941876,
-0.010437804,
-0.0058991937,
0.007176407,
-0.027505115,
-0.011758369,
-0.039083406,
-0.031987034,
-0.012205228,
-0.013625836,
0.013045588,
-0.027478436,
-0.021622594,
0.012525365,
-0.002442713,
0.01274546,
0.017287405,
0.01763422,
0.002315992,
0.018861413,
0.018074408,
-0.018021053,
-0.00120635,
-0.014392831,
-0.022009427,
-0.018981464,
-0.001648206,
-0.0051488723,
0.029612685,
-0.01287885,
-0.009437376,
-0.005145537,
-0.017060641,
0.02255633,
-0.019114854,
0.0121385325,
0.030039534,
-0.0017107328,
0.005388975,
-0.0257577,
-0.030866554,
0.013212326,
-0.014873037,
-0.012898859,
0.005755799,
0.036175497,
0.0018791382,
-0.00867705,
0.010964696,
0.014793003,
-0.0027311698,
-0.024863983,
0.00040246407,
0.0056224084,
0.007723308,
-0.009357342,
0.027171638,
-0.0010729596,
-0.0023810198,
-0.018421223,
-0.014432848,
0.05709112,
0.015353243,
-0.020915626,
0.037162583,
-0.0022976508,
-0.022289548,
-0.10068312,
-0.00080451125,
0.0027194982,
0.0074765356,
-0.013032249,
0.020608827,
-0.0031330087,
0.00088788033,
0.0072697806,
0.019408314,
0.0111981295,
-0.006199322,
0.0014564572,
-0.0057724724,
0.03414796,
0.001494807,
0.051301975,
-0.013659184,
-0.03374779,
0.04159115,
-0.008216853,
0.0069363043,
0.018661326,
-0.01734076,
-0.0043485295,
0.008350244,
-0.02631794,
0.0086370325,
0.0014914721,
0.02841217,
0.013359056,
-0.00076949626,
0.0079233935,
0.03065313,
-0.015206513,
-0.012992232,
-0.037162583,
-0.016313653,
0.025250815,
-0.025557613,
-0.010717924,
0.017540846,
0.0009970937,
0.002407698,
0.009524079,
-0.012125194,
-0.037536077,
0.005529035,
0.012632078,
-0.000027694154,
-0.013752557,
-0.020141961,
-0.018634649,
0.0059258714,
0.004211804,
-0.025717683,
0.007449858,
-0.025237476,
-0.020382063,
-0.012325279,
-0.012345288,
-0.012658755,
-0.0100709805,
-0.003002953,
-0.0022793096,
0.013925965,
-0.007649943,
-0.00080075965,
0.0080367755,
-0.0068762787,
-0.016126908,
-0.006816253,
-0.0042017996,
-0.006422751,
-0.015980178,
-0.0077032996,
-0.02755847,
-0.013492446,
-0.00050563324,
-0.006829592,
-0.011811726,
-0.018941447,
0.019221567,
-0.011564953,
0.034921624,
0.0073164674,
0.019621737,
-0.0015656706,
0.033267584,
-0.019341618,
-0.0068029137,
0.012865511,
-0.0038149673,
-0.015233192,
-0.027251672,
-0.0065528066,
0.003051307,
-0.018541275,
0.010271066,
0.03009289,
-0.024183692,
-0.016913911,
-0.07048352,
0.032147102,
0.035615254,
0.0015831782,
-0.025144104,
-0.011638318,
0.034201317,
0.011291503,
0.011731692,
0.007109712,
0.0025027387,
0.0034681521,
-0.03732265,
0.014459527,
-0.031240048,
-0.024717255,
0.0071163815,
-0.00033180878,
0.026224567,
0.018141104,
-0.002526082,
0.00064861117,
0.004561954,
0.01834119,
0.008997187,
0.0027328373,
-0.014752986,
0.014112712,
-0.0020242003,
0.0021659278,
0.011871751,
-0.021049015,
0.00016361175,
0.010804628,
-0.028652273,
-0.00966414,
0.01273212,
0.0257577,
-0.0015573337,
0.009924251,
0.002022533,
-0.03220046,
0.023543417,
-0.014953071,
0.023903573,
0.013259012,
-0.012798815,
0.000089621724,
-0.0085636685,
0.00088788033,
0.018181121,
-0.00434186,
-0.0037416026,
-0.015126479,
-0.016687147,
0.0060492577,
0.007910055,
-0.009197273,
-0.029159157,
-0.017754272,
0.033374295,
-0.00038057967,
0.007863368,
0.0041351044,
0.01203849,
0.001685722,
-0.019888518,
0.0013239004,
-0.0036315555,
-0.015179835,
-0.030973267,
0.0081501575,
0.020128623,
0.0022843117,
0.032413885,
-0.01497975,
-0.04447238,
0.012678764,
-0.007429849,
0.014739647,
0.03244056,
-0.023530079,
-0.0215559,
-0.010624551,
-0.000853699,
0.014152729,
-0.005979228,
0.022743074,
-0.0061059487,
0.01091801,
-0.010857984,
0.010978036,
0.00030909074,
-0.006429421,
0.0045786276,
0.02631794,
0.024036963,
-0.026277922,
0.009724165,
0.04799389,
0.0029162492,
0.01651374,
-0.00037474386,
-0.015980178,
-0.030413026,
-0.012011812,
-0.02056881,
-0.035748646,
-0.0201553,
0.022583006,
0.038789947,
0.024183692,
0.018728022,
0.015019767,
-0.021635935,
0.013385734,
0.017020624,
-0.0004174705,
0.005135533,
0.042044677,
0.006909626,
0.027638504,
0.0065394677,
-0.0026778136,
0.017020624,
-0.0011288169,
0.03862988,
-0.017207371,
0.037722826,
0.007609926,
0.008276879,
0.014606256,
-0.011018053,
0.0067395535,
0.0023926916,
-0.03473488,
-0.007209755,
0.0118784215,
0.0011354864,
0.09892237,
-0.0010454478,
-0.016847216,
-0.010104328,
-0.0064160815,
0.009217282,
0.014659612,
0.0074832053,
0.0014481202,
-0.029906143,
0.010304414,
-0.019915197,
0.018594632,
-0.028305458,
-0.026718112,
0.010764611,
0.019274922,
0.010397787,
0.0016757178,
-0.029319225,
0.038389776,
-0.015473294,
-0.0091039,
0.01497975,
-0.03468152,
-0.0031413455,
0.028732307,
0.017901001,
-0.007816682,
-0.04631317,
0.010104328,
0.000087902234,
-0.014592918,
-0.025717683,
0.022823108,
-0.010424465,
-0.01567338,
-0.024303744,
0.019795146,
0.0033981223,
-0.030493062,
0.02378352,
-0.0070430166,
-0.012158541,
-0.01888809,
-0.016593775,
-0.018861413,
-0.028598916,
-0.013379064
] |
Histone levels are tightly regulated to prevent harmful effects such as genomic instability and hypersensitivity to DNA-damaging agents due to the accumulation of these highly basic proteins when DNA replication slows down or stops. Although chromosomal histones are stable, excess (non-chromatin bound) histones are rapidly degraded in a Rad53 (radiation sensitive 53) kinase-dependent manner in Saccharomyces cerevisiae. Here we demonstrate that excess histones associate with Rad53 in vivo and seem to undergo modifications such as tyrosine phosphorylation and polyubiquitylation, before their proteolysis by the proteasome. We
|
[
-0.013664529,
-0.02075083,
0.0071531534,
-0.028051058,
-0.035297804,
0.026112353,
-0.00553868,
0.009065118,
-0.008356487,
0.0007696325,
-0.006859005,
-0.020189274,
0.023358054,
0.0014949756,
-0.004499133,
-0.008122507,
0.033479434,
-0.030029874,
-0.011719138,
-0.009452859,
-0.0358861,
0.0002158063,
-0.008610525,
-0.03478973,
-0.0132834725,
0.01581716,
0.008677376,
-0.028773058,
0.0034829841,
-0.013250047,
0.01196649,
0.015950864,
0.015536382,
0.015389308,
-0.0019420477,
-0.0025537426,
0.022328535,
-0.0024768629,
-0.0018568116,
-0.01722105,
0.0031804792,
0.014747529,
-0.012434454,
0.00013401717,
-0.0018551403,
0.008303006,
0.012434454,
-0.0035565211,
-0.001774918,
0.019092903,
0.023558611,
0.03200869,
-0.017782606,
0.012955898,
-0.015496271,
-0.010783212,
0.008356487,
0.017354753,
-0.01195312,
-0.011545324,
0.0057058097,
-0.014680678,
-0.021165311,
0.022783129,
0.006227255,
0.0204032,
0.011478472,
-0.008490192,
0.011679027,
-0.013484029,
0.026072241,
0.005802745,
-0.012741973,
-0.0004917793,
-0.00002154407,
-0.021833831,
-0.018357532,
-0.011946435,
0.019868385,
0.01441327,
0.037731215,
-0.01320325,
0.000105552885,
-0.004261809,
0.012614954,
0.011338082,
-0.004515846,
0.00789521,
0.010255082,
-0.0034194747,
0.014132492,
0.03658136,
0.029388096,
0.02422713,
-0.008309691,
0.023358054,
-0.005144254,
0.021994276,
-0.018905718,
-0.020483423,
-0.008690747,
0.014934715,
-0.01722105,
-0.015523012,
-0.031046024,
-0.014881234,
0.025229909,
-0.0151085295,
-0.0075141536,
-0.015616604,
-0.018611569,
0.017755866,
0.0007867633,
-0.04003092,
0.039897215,
-0.016606012,
0.032917876,
0.012802139,
0.0050640316,
-0.024347464,
0.012868991,
0.046849813,
0.034228172,
-0.027997576,
0.008744229,
-0.0010662879,
-0.005194393,
-0.00027534628,
-0.0039810305,
-0.005903023,
0.004332003,
0.008075709,
0.016565902,
0.015536382,
-0.030110097,
0.027489502,
-0.009038378,
-0.0071865795,
-0.0038172435,
-0.04754507,
0.0055019115,
0.030110097,
-0.016231641,
0.0041381326,
0.011003823,
0.0038874382,
-0.007527524,
0.029040467,
-0.013758121,
0.004128105,
0.008022228,
0.016646124,
0.018571459,
-0.012768714,
0.0015367582,
0.009258988,
-0.010629453,
-0.010315249,
-0.028184762,
-0.018745273,
0.016418828,
-0.016325235,
0.013577621,
0.002027284,
0.005481856,
0.032463282,
-0.0147609,
0.008904673,
0.00007922995,
-0.015736938,
-0.0077347653,
0.017822716,
-0.032249358,
0.009352582,
-0.025376981,
0.010034471,
0.0041013644,
0.022221573,
-0.037784696,
-0.018571459,
-0.018090125,
0.0074205613,
0.012441139,
0.020964757,
-0.013417177,
0.008189358,
0.026580317,
-0.01754194,
0.0013428876,
-0.009706896,
-0.0014531933,
0.0069058016,
-0.023023795,
-0.024548018,
-0.6417783,
-0.021593165,
-0.0052879853,
-0.028051058,
0.0015476216,
0.03190173,
0.032837655,
0.01687342,
-0.024120167,
0.023050535,
-0.013377066,
0.020871164,
0.034869954,
-0.03473625,
-0.03968329,
-0.047652036,
-0.004639522,
-0.021018239,
0.024347464,
0.0020022145,
-0.033853803,
-0.00863058,
-0.01929346,
0.005277958,
0.0074272463,
0.016191531,
0.025256649,
-0.00789521,
-0.0039275493,
0.041555144,
-0.04003092,
0.0147609,
-0.018477866,
0.017408235,
0.042143438,
0.006471264,
-0.0037002529,
0.01209351,
0.033773582,
0.044764034,
0.0024400945,
-0.012146991,
0.017114086,
0.0061904863,
-0.023826018,
0.023558611,
-0.0041013644,
0.010248397,
0.0032222618,
-0.0034194747,
0.005545365,
-0.017742494,
-0.011491842,
0.0087108025,
0.0047264295,
0.02283661,
0.015309085,
-0.014827752,
-0.0052378466,
0.01089686,
0.0032556877,
0.02069735,
-0.020082312,
-0.017742494,
-0.038479954,
0.017608792,
-0.004582698,
0.007534209,
0.0012091838,
0.0041481606,
0.022997055,
0.005481856,
0.007159839,
-0.005582134,
0.008824451,
0.020991497,
0.0064746067,
0.017595422,
-0.015295715,
0.026259428,
0.012868991,
-0.010936971,
-0.024454426,
-0.0002603046,
0.01177262,
-0.011819417,
-0.024708463,
0.029468318,
-0.0010654522,
-0.007968747,
-0.0072534312,
0.022047758,
-0.0050807446,
-0.011057304,
-0.038961288,
0.024802055,
0.016325235,
0.01727453,
-0.005481856,
-0.0076010614,
-0.040966846,
-0.0047598556,
-0.004465707,
0.01727453,
0.011739194,
-0.007594376,
-0.028933503,
-0.008316376,
0.03794514,
0.007674598,
0.0066517643,
-0.002010571,
-0.01089686,
-0.012040027,
-0.009606618,
-0.019106274,
0.0287998,
0.019159755,
-0.022234943,
-0.012507991,
0.024387574,
-0.006250653,
0.011525268,
-0.012621639,
0.01248125,
0.019961977,
-0.0021192052,
-0.0013946978,
-0.009446174,
-0.006330875,
0.022341905,
0.0034595858,
0.0316878,
-0.03826603,
0.013731381,
-0.0018501264,
0.009907451,
-0.007099672,
0.031152986,
-0.036313955,
-0.015028307,
-0.007634487,
-0.011224435,
0.012167046,
-0.011819417,
-0.03128669,
-0.02704828,
0.003747049,
0.01726116,
0.01441327,
0.01299601,
0.019239977,
-0.012608268,
0.01143836,
0.005866254,
-0.007935321,
-0.0018952515,
-0.029227652,
-0.008470136,
-0.011411619,
-0.0009334197,
0.012708547,
-0.005013893,
0.0073670796,
-0.010415526,
-0.031420395,
0.01018823,
-0.007962061,
-0.019413792,
-0.009539766,
-0.012868991,
-0.004144818,
-0.039496105,
0.020202644,
0.020443311,
0.029334614,
-0.0014423298,
0.0074071907,
0.0022194833,
-0.01157875,
-0.00790858,
0.001151524,
-0.020470053,
-0.019801533,
0.02420039,
0.03160758,
0.019560866,
-0.0041815867,
-0.0007671256,
0.023785906,
0.00010299371,
0.0061604027,
-0.0047398,
-0.005672384,
0.0066317087,
-0.041956253,
0.01617816,
0.00501055,
0.0052445317,
0.023344684,
0.015188752,
-0.014974826,
-0.0044389665,
-0.012307435,
0.01754194,
-0.01722105,
-0.0002534105,
-0.011104101,
-0.018477866,
0.013657844,
-0.0021091774,
-0.004268494,
-0.010803267,
-0.0026256084,
0.0053682076,
0.010228341,
-0.011518583,
0.0059565045,
0.0012476236,
-0.010796582,
0.005655671,
-0.01649905,
0.026433242,
0.0018584828,
-0.007982117,
-0.011344768,
0.007520839,
0.03187499,
-0.008062339,
0.0069124866,
-0.014252826,
0.016271753,
-0.020510163,
-0.0025754694,
0.024441056,
0.030163579,
0.010295193,
-0.008122507,
0.0256845,
0.012146991,
-0.021392608,
-0.009586562,
-0.016619382,
-0.011852842,
-0.0068021812,
0.009332526,
0.037009213,
0.013784862,
0.0016621054,
-0.0026256084,
-0.013022751,
0.011979861,
-0.004325318,
0.02533687,
0.006711931,
-0.02391961,
0.020964757,
0.016793197,
0.032516766,
-0.00016336933,
-0.0007537552,
-0.011224435,
-0.006892431,
-0.016298493,
-0.0147609,
-0.012253954,
0.008984895,
-0.003190507,
-0.011959805,
-0.0054384023,
-0.019400422,
0.00081517536,
-0.01442664,
-0.005903023,
0.017087346,
0.0022395388,
0.019146385,
0.017622162,
0.013256732,
0.008155932,
-0.02778365,
-0.030511208,
0.03265047,
0.013363696,
-0.002577141,
-0.001982159,
-0.03192847,
-0.020162534,
-0.0035765767,
0.031179728,
-0.013865084,
0.018758643,
-0.018090125,
0.006721959,
-0.014747529,
-0.011097415,
0.010047841,
-0.029495059,
0.037223138,
-0.009874026,
-0.0018183717,
-0.006421125,
-0.0037303362,
-0.007828358,
0.029093947,
0.010990453,
-0.004549272,
0.0026306224,
-0.015910752,
-0.021098461,
-0.0018217143,
-0.0014682349,
0.00015825099,
0.0016395429,
-0.008984895,
0.0017548625,
-0.005789375,
-0.004823365,
0.025122944,
0.0023130758,
-0.017087346,
-0.022997055,
-0.012133621,
0.004599411,
0.02492239,
0.03192847,
-0.027222095,
0.007594376,
-0.0018868949,
0.014306307,
-0.007855099,
-0.046315,
0.039255437,
-0.013651159,
0.0031587523,
0.013824973,
-0.0006990202,
0.013183195,
0.007119728,
0.018718533,
0.016793197,
-0.02633965,
-0.015977604,
0.010402156,
0.0064445236,
0.0049169576,
0.018197088,
0.032195877,
0.028478911,
-0.011003823,
0.014667307,
0.016458938,
0.008155932,
-0.009406063,
-0.0060133287,
0.026927946,
0.004261809,
0.022047758,
-0.015884012,
-0.030163579,
0.017822716,
0.011973175,
0.0034228174,
-0.0031554098,
0.013236676,
0.006280736,
0.027128503,
0.025189796,
-0.011518583,
0.0060801804,
0.017167568,
0.024882277,
-0.035725657,
-0.013972048,
0.023612091,
-0.013477343,
-0.023531869,
-0.012233898,
-0.0016604341,
-0.037544027,
0.021486202,
-0.025350241,
-0.011037249,
-0.0014707418,
-0.0056489855,
-0.0099275075,
0.018531347,
0.0065681995,
-0.0006196336,
-0.010041156,
0.011658972,
-0.025002612,
-0.019213237,
-0.010128063,
0.0111575825,
-0.039175216,
-0.03687551,
0.008924729,
0.037089434,
0.016204901,
-0.0006580734,
-0.024775315,
-0.0123609165,
0.0017983161,
-0.016378716,
-0.0055520507,
-0.0049570687,
-0.029949652,
-0.0051041427,
-0.019159755,
-0.0012718574,
0.0022595944,
-0.0231575,
-0.003100257,
0.022582572,
-0.020256126,
0.022114608,
-0.02420039,
-0.019547496,
0.01617816,
0.024080055,
0.035993066,
0.014894604,
-0.0030885579,
-0.01405227,
-0.0046261516,
-0.025430463,
-0.0108500635,
0.0027659975,
-0.02600539,
-0.001791631,
0.0065514864,
-0.0029581967,
-0.011197694,
0.009332526,
-0.0065982826,
-0.007072931,
0.011973175,
0.025256649,
0.015068418,
0.0053214114,
0.029949652,
-0.02636639,
-0.013958677,
-0.011946435,
-0.01687342,
0.022555832,
-0.004786596,
-0.01825057,
0.011933064,
-0.0015267304,
-0.025831575,
-0.018411014,
-0.014827752,
-0.014132492,
0.031447135,
-0.0077414503,
-0.024307352,
-0.023732426,
-0.022395387,
0.0024584788,
-0.0038205863,
0.008677376,
-0.02391961,
-0.013945307,
-0.00493367,
-0.0012024986,
-0.012307435,
-0.027008168,
-0.039496105,
-0.011672342,
0.012715232,
-0.007581006,
-0.007099672,
0.0066918754,
-0.007119728,
-0.010141433,
-0.0158439,
-0.012775399,
-0.03821255,
0.03192847,
0.026326278,
0.03369336,
0.027195353,
0.0351641,
-0.0011130841,
0.007453987,
0.021726869,
0.020068942,
-0.0060500973,
-0.008336432,
0.026927946,
-0.019748053,
0.014119122,
-0.0065013473,
-0.008844507,
0.013336955,
-0.014854493,
0.020617127,
0.046849813,
0.010943657,
-0.029227652,
0.015202123,
-0.035591953,
-0.026419872,
0.014346418,
-0.02214135,
0.00019616855,
-0.038105585,
-0.005755949,
-0.000287881,
-0.0010328619,
0.0076545426,
-0.024882277,
0.023277832,
-0.0033576367,
0.009158711,
-0.009178766,
0.008536988,
0.0035799195,
-0.009245618,
0.0020523535,
0.011926379,
0.024133537,
0.0013871769,
0.018477866,
-0.014132492,
-0.008924729,
0.0005657342,
0.009091859,
-0.032543506,
-0.026834354,
-0.017715754,
-0.0023782565,
-0.008897988,
0.00049470406,
-0.0023348026,
-0.036768544,
0.013918566,
-0.007801617,
-0.0056523285,
0.001510853,
0.0071865795,
-0.0057258653,
0.02218146,
-0.013149769,
0.023571981,
-0.014881234,
-0.00048425846,
0.021900684,
0.0017665615,
-0.010194915,
-0.014159233,
-0.02141935,
0.009706896,
0.043828107,
0.013390436,
-0.016579272,
-0.0042384104,
-0.006721959,
0.0070461906,
-0.0030300624,
-0.044095516,
0.00060709886,
-0.017341383,
-0.0025988678,
0.0051475964,
0.0120667685,
-0.014894604,
0.006601625,
0.017648902,
0.027730169,
0.012387658,
0.0025687844,
-0.0087041175,
0.00457267,
0.009700211,
0.037383582,
-0.0005811937,
-0.004689661,
-0.009820544,
0.00057200156,
-0.0013428876,
0.010255082,
-0.011251175,
0.051128335,
-0.014948085,
-0.011124156,
0.019761423,
0.005983245,
-0.004499133,
-0.010836693,
0.0033342387,
0.033479434,
-0.020577015,
-0.010081267,
0.009533081,
0.024815425,
-0.014199344,
-0.002067395,
-0.008216099,
-0.002067395,
-0.033131804,
0.0102350265,
0.02421376,
0.008109136,
0.00023043015,
-0.021994276,
-0.011598805,
0.0050874297,
-0.025497315,
-0.029388096,
0.018838866,
-0.045833666,
-0.018451124,
0.0010570957,
0.011204379,
0.02075083,
-0.0009543109,
0.009706896,
0.001915307,
0.022649424,
-0.0021409323,
0.008864562,
0.004870161,
0.0029531827,
-0.025015982,
0.009426118,
-0.018437754,
-0.009940878,
0.0024768629,
-0.0057994025,
-0.040512253,
0.006986024,
-0.00012472058,
0.019587608,
0.04257129,
-0.012768714,
-0.0046328367,
0.0023515157,
0.023678944,
0.012822195,
-0.0142127145,
0.02813128,
-0.025564168,
0.0025821547,
0.01018823,
-0.01231412,
-0.023438277,
-0.008296321,
-0.019413792,
0.00914534,
0.0032757432,
-0.00276934,
-0.006752042,
-0.0076411725,
-0.001836756,
0.007794932,
0.008476821,
-0.018544717,
-0.010749786,
0.010388786,
-0.011311342,
0.0025988678,
-0.019948607,
0.011665657,
0.005712495,
0.0054183467,
0.0036033175,
0.0056021893,
0.013363696,
-0.027649947,
-0.034335136,
0.012434454,
-0.004515846,
0.04358744,
0.010756471,
-0.01405227,
-0.0058495416,
-0.005224476,
-0.04321307,
-0.003797188,
-0.0076478575,
0.0096601,
0.019895125,
0.028318467,
-0.010061211,
-0.01230075,
0.0005314726,
0.03235632,
0.0182372,
-0.013744751,
0.0045459294,
-0.011792676,
0.018531347,
0.013450603,
-0.015750308,
0.002786053,
0.033613138,
0.00068941026,
-0.02778365,
0.0316878,
0.010268453,
0.037089434,
-0.011170953,
0.040645957,
0.013470658,
0.03946936,
0.004549272,
-0.038800843,
-0.0026439927,
0.0045459294,
0.010916916,
-0.028880022,
0.020109052,
-0.02073746,
-0.002398312,
-0.0056991247,
-0.012548102,
-0.029388096,
-0.012621639,
-0.03618025,
0.025577538,
0.015375937,
0.004960411,
0.0105358595,
0.0065982826,
-0.018638311,
-0.0013855057,
-0.021486202,
-0.014145862,
-0.008951469,
-0.004525874,
-0.03446884,
-0.012775399,
0.011130841,
0.01070299,
-0.0024400945,
-0.0024334092,
0.005786032,
-0.022275053,
-0.046154555,
0.017047236,
-0.011518583,
0.0008849521,
0.0016420499,
-0.009412748,
-0.017675644,
-0.0032640442,
0.016565902,
-0.005685754,
-0.006060125,
0.007948691,
-0.013631103,
-0.014012159,
-0.0132901585,
-0.01687342,
-0.0035698917,
-0.022916833,
0.0148143815,
0.18258591,
-0.004987152,
-0.003533123,
-0.00057325506,
-0.0111375265,
-0.022676164,
0.010489063,
-0.008984895,
-0.014319678,
0.0066985604,
0.015255604,
0.016686235,
-0.018370902,
-0.0015167026,
0.012909102,
-0.0094796,
-0.01723442,
-0.002415025,
-0.02418702,
0.0072266906,
0.022636054,
-0.007948691,
-0.009472915,
0.00061085925,
0.029227652,
-0.01827731,
-0.025216537,
-0.003740364,
-0.0148143815,
0.011886268,
-0.036420915,
-0.002707502,
-0.0029030438,
-0.0076478575,
0.0060567823,
0.00009239142,
-0.009559822,
-0.0033576367,
-0.002538701,
-0.007527524,
-0.007835043,
0.0096601,
-0.01581716,
-0.015335826,
-0.0048333923,
-0.020510163,
0.0032256043,
0.0054250318,
-0.025069464,
0.0014715774,
-0.043828107,
-0.0007504126,
0.008383228,
0.02394635,
-0.0057258653,
0.0037737899,
0.0132968435,
0.0014690706,
-0.023826018,
0.03235632,
-0.014680678,
-0.0072801723,
-0.04350722,
0.002415025,
-0.009907451,
0.031126246,
-0.029200912,
-0.0047732256,
0.030243801,
-0.0057325508,
0.00949297,
0.0058495416,
-0.01683331,
0.0012434453,
0.0061804582,
-0.017100716,
0.04457685,
0.0063241897,
0.03449558,
0.00519105,
-0.00013224142,
-0.0045626424,
-0.025564168,
0.009894081,
0.000059539976,
-0.029361356,
0.026607057,
0.007119728,
-0.02073746,
-0.0071464684,
0.008282951,
-0.005819458,
-0.006320847,
-0.0056523285,
0.0029548542,
-0.0036367434,
-0.00085069047,
0.011404934,
-0.008670691,
-0.012340861,
-0.039282177,
0.0674402,
-0.0069124866,
0.02666054,
-0.018517977,
-0.0077882465,
0.0009568178,
0.016204901,
-0.010174859,
-0.021111831,
0.00985397,
-0.015268974,
0.01726116,
-0.0120667685,
0.000889966,
0.016138049,
-0.012507991,
-0.022047758,
0.05128878,
-0.011665657,
0.010662878,
-0.021004867,
0.010876805,
0.021192053,
-0.007821673,
0.0065681995,
-0.011892953,
0.01651242,
-0.021566425,
-0.05104811,
0.012227213,
-0.009767063,
0.013477343,
0.00036643198,
0.004763198,
-0.03789166,
0.006006643,
-0.022636054,
-0.0017682328,
0.020978127,
-0.002869618,
-0.0033442664,
0.022074498,
0.009452859,
-0.011431675,
-0.008657321,
0.008249525,
0.014653937,
-0.0058328286,
-0.010475693,
0.0033158544,
-0.008744229,
0.005154282,
-0.0033292247,
-0.013397121,
-0.029735725,
-0.00701945,
-0.03513736,
-0.016311863,
0.035591953,
-0.023291202,
0.013316899,
0.026861094,
-0.0033693358,
-0.011043934,
-0.009472915,
-0.16835983,
0.025858317,
0.01970794,
-0.035351288,
0.007982117,
0.028238244,
0.033987507,
-0.0013136399,
-0.01232749,
0.009847285,
0.00017548625,
0.005348152,
-0.043694403,
-0.047197443,
0.011705768,
0.0019203209,
0.029227652,
0.037276622,
0.019774793,
-0.0014356446,
-0.0012509662,
-0.011491842,
0.036661584,
-0.011277916,
0.0023481732,
0.020336349,
-0.0064278105,
-0.020082312,
0.010502433,
-0.013430547,
-0.0069191717,
0.007861784,
0.012507991,
0.004174901,
0.0105358595,
0.009232247,
0.0034729564,
0.005745921,
-0.004275179,
0.00022896776,
0.029254392,
0.010970397,
0.005582134,
-0.012962583,
0.024400944,
0.044068772,
0.0018083439,
0.00094344746,
0.011418305,
-0.02283661,
0.012340861,
-0.0009910795,
0.016111309,
0.032490026,
0.014373159,
0.008343117,
-0.008048969,
0.02042994,
-0.0048267073,
-0.0055085965,
-0.004385485,
-0.019400422,
0.046181295,
-0.009218877,
-0.0061771157,
-0.011799361,
-0.012180417,
0.013076232,
-0.025363611,
-0.00050598534,
0.009693526,
0.0033191969,
0.0075609502,
0.0028378633,
-0.0064512086,
0.01352414,
0.011237805,
0.011104101,
-0.016445568,
-0.009773748,
-0.012889047,
0.015081789,
-0.028505651,
-0.03414795,
-0.025483945,
-0.008309691,
-0.0071063573,
0.008476821,
-0.01282888,
0.002095807,
0.011144212,
0.0012760357,
0.012882361,
-0.00395429,
0.02248898,
0.0074071907,
-0.008744229,
0.015964234,
-0.018116865,
-0.0072801723,
0.012401028,
-0.021726869,
-0.012648379,
-0.003633401,
0.044523366,
0.013637788,
-0.009974304,
0.016606012,
0.04845426,
-0.007835043,
-0.0051108277,
-0.005247874,
0.010890175,
0.017689014,
0.014627196,
0.03684877,
0.004184929,
0.012287379,
-0.009386007,
-0.006695218,
0.06936553,
-0.00019115466,
-0.026861094,
0.010067897,
-0.006217227,
-0.01333027,
-0.13787536,
0.004218355,
-0.0021476173,
0.003673512,
-0.0029114003,
0.0042417534,
0.009025007,
0.016418828,
-0.00896484,
0.025470575,
-0.020857794,
0.0062138843,
-0.0083965985,
-0.013303529,
-0.008349802,
0.0068055238,
-0.005301356,
-0.010328619,
-0.0011222763,
0.019520756,
-0.0053046984,
-0.004455679,
0.0038205863,
-0.0026807613,
0.017996533,
0.004993837,
-0.030430986,
0.019774793,
0.012133621,
0.006006643,
-0.0068422924,
0.00483005,
-0.014252826,
0.0039442624,
-0.0123676015,
0.0009401049,
-0.0027542983,
-0.024173647,
0.027355798,
-0.010034471,
-0.0037938454,
0.015603234,
0.026486723,
0.013263417,
0.01899931,
-0.0045225313,
-0.004442309,
0.01441327,
0.014440011,
-0.010001045,
-0.024106797,
-0.0056423005,
-0.026326278,
-0.03339921,
0.018772013,
-0.010656193,
0.026927946,
0.020938016,
-0.028585874,
0.007206635,
-0.007587691,
0.01649905,
-0.024106797,
0.005789375,
0.006023356,
-0.019761423,
-0.019239977,
-0.018036643,
0.021125201,
-0.025885057,
-0.0013838344,
0.008456766,
-0.02420039,
0.0048835315,
-0.013417177,
0.008911358,
-0.041287735,
-0.006508033,
0.014105751,
-0.0065681995,
0.004191614,
-0.009827229,
0.0108433785,
-0.034656025,
0.02462824,
-0.0021609878,
0.012594898,
-0.0035398083,
0.0039442624,
0.012915787,
-0.0011364823,
0.051208556,
-0.003549836,
-0.011552009,
-0.009787118,
0.036046546,
-0.00950634,
-0.01231412,
0.013484029,
0.03374684,
-0.021566425,
0.0006960954,
-0.032891136,
0.015482901,
0.007166524,
-0.014961456,
0.022823239,
-0.016793197,
-0.0111575825,
0.013390436,
-0.016218271,
-0.002415025,
-0.004332003,
0.0027743538,
-0.013303529,
-0.009486285,
-0.034228172,
-0.0196812,
0.03454906,
0.0027041594,
0.035672177,
0.034014247,
-0.006217227,
-0.0067954957,
0.011110786,
0.012935843,
-0.01684668,
-0.0035765767,
0.01000773,
0.010428897,
-0.0032556877,
0.005291328,
0.032490026,
-0.044817515,
-0.014988196,
-0.0037303362,
-0.0018751959,
-0.026192576,
-0.028024318,
0.019440534,
0.0039442624,
0.021151941,
-0.028986985,
-0.047250923,
-0.011612175,
-0.00023356383,
-0.012601583,
0.015616604,
-0.04754507,
0.005388263,
-0.0031587523,
-0.019480644,
0.028612614,
0.017729124,
0.010983768,
-0.028933503,
-0.014292937,
0.0025804834,
-0.000835231,
0.004021142,
0.008610525,
-0.025216537,
-0.021379238,
0.005745921,
0.014453381,
0.011645601,
-0.013497399,
0.0053949486,
-0.019855015,
-0.018571459,
-0.0031771366,
-0.035431508,
-0.03195521,
0.019226607,
0.02845217,
-0.00449579,
0.0019420477,
0.0061470326,
-0.032222617,
-0.0015258946,
-0.009807174,
-0.00069358846,
0.008924729,
-0.011598805,
-0.015349196,
0.008904673,
0.051101595,
-0.017715754,
0.0020573672,
0.020269496,
0.0041982993,
0.027329057,
-0.017328013,
0.026139094,
0.016886791,
0.007534209,
0.0019754737,
0.015081789,
-0.02561765,
-0.0027877244,
0.0014431655,
0.022743016,
-0.0046595777,
0.009800489,
-0.01684668,
-0.010094637,
-0.009058433,
0.033800323,
-0.008824451,
-0.036955733,
0.0076077464,
-0.0005360687,
0.028719578,
0.015055048,
0.015255604,
0.0019587607,
-0.0015175382,
0.01195312,
-0.004870161,
-0.018731903,
0.0043119476,
0.037864916,
0.011324712,
-0.005762634,
-0.008677376,
0.0011548667,
0.045218628,
-0.021125201,
0.011204379,
-0.029602023,
0.0043554013,
-0.019079532,
0.01929346,
-0.025951909,
-0.049069297,
-0.011632231,
-0.012741973,
0.0019387052,
0.009606618,
0.032837655,
-0.011030564,
0.07535546,
0.005869597,
-0.009459544,
0.013631103,
-0.009559822,
0.024280611,
0.01969457,
0.005588819,
-0.017114086,
-0.027623206,
0.009767063,
-0.035431508,
0.04179581,
-0.020282866,
0.01125786,
0.024828797,
-0.008764285,
0.018103495,
0.0071932646,
-0.03125995,
0.016779827,
-0.01195312,
-0.00439217,
0.009947563,
-0.024400944,
-0.0010637809,
0.020897904,
0.007440617,
-0.00078216725,
-0.028612614,
0.013002695,
-0.0047832537,
-0.021847202,
-0.017836088,
-0.004071281,
0.007962061,
-0.005859569,
0.0029364699,
0.022047758,
0.0038740677,
0.010034471,
-0.019868385,
0.015095159,
-0.010569286,
0.0038840955,
0.015696827,
-0.0014214385,
-0.00064010697,
0.009533081
] |
TLR sense microbial infections, and control activation of immune responses. Dendritic cells, macrophages, and B lymphocytes express TLR and the TLR-signaling adaptor protein MyD88. The impact of TLR-activated B cells on T cell-mediated inflammation is unknown. In this study, we have used mice carrying B cell-restricted deficiencies in MyD88 or in distinct TLR to examine the impact of TLR-activated B cells on a T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis (EAE). We demonstrate that TLR-signaling in B cells suppresses inflammatory T cell responses
|
[
-0.042076524,
-0.0095842425,
-0.013225731,
-0.030360997,
-0.021992764,
0.00817864,
-0.015520458,
-0.00041085246,
-0.020175288,
-0.017154878,
0.0028569673,
0.0013410421,
0.0069691692,
-0.0049261437,
-0.0000046191535,
0.016043473,
0.03506813,
0.011414793,
-0.008237479,
-0.005883914,
-0.022607306,
0.018227058,
-0.003478047,
-0.02434633,
-0.001729217,
0.0062042605,
0.003089055,
-0.061924927,
-0.03007334,
0.0041318154,
0.0115324715,
-0.005158231,
-0.015847342,
0.00026886218,
-0.00012952783,
-0.017416386,
0.03159008,
-0.0053805127,
0.037918556,
0.012192777,
0.015585834,
0.0054589645,
0.0038376194,
-0.0051320805,
0.010525668,
0.009963428,
0.015102046,
-0.016370356,
-0.017965551,
0.003987986,
0.027013702,
-0.027667472,
-0.026765272,
-0.0065899836,
-0.03043945,
-0.0070476215,
0.008995851,
0.017167954,
0.005285716,
-0.038075462,
-0.011584773,
-0.005991786,
-0.013925264,
-0.012924998,
0.004488119,
0.012473898,
0.010865628,
0.020149136,
0.0035107355,
-0.0075640986,
0.03156393,
0.01506282,
0.004154697,
-0.002098596,
0.0036872528,
-0.022345798,
-0.02115594,
0.00691033,
-0.0072764405,
-0.0019318851,
0.012558888,
-0.0051941886,
0.00032381958,
0.015115121,
0.008276706,
-0.008799721,
0.011918195,
-0.0037297478,
-0.0106891105,
-0.009728071,
-0.013206118,
0.021221317,
0.021678954,
0.05159539,
0.0027997624,
0.019273087,
0.014513655,
0.033943646,
-0.011146748,
-0.015102046,
-0.0026804497,
0.00010373463,
0.0010264161,
-0.015677363,
-0.030308696,
0.006844953,
-0.021247467,
-0.005573374,
0.024241725,
-0.019037731,
-0.037029434,
0.031380873,
0.001729217,
-0.05057551,
0.02344413,
0.031877737,
-0.00029092687,
-0.0016916253,
-0.007805993,
0.018750073,
0.018501641,
0.033525236,
-0.011369029,
-0.007884445,
0.0086755045,
0.00953194,
0.013153817,
0.005779311,
-0.021927387,
0.008211329,
0.0034943912,
0.033760592,
-0.012676566,
0.0027213104,
-0.0011081372,
0.008008661,
-0.019416917,
-0.0014489138,
-0.018723922,
-0.0029860863,
0.005168038,
0.042782594,
-0.008100188,
-0.017651742,
0.023561807,
0.030021038,
0.04814349,
0.007655626,
-0.007073772,
0.016161151,
-0.037107885,
-0.031459328,
0.01119905,
-0.01867162,
-0.00024761472,
0.00078452186,
-0.021600502,
0.04618219,
-0.0019645735,
-0.005740085,
-0.0077863797,
-0.019299239,
0.023679486,
-0.0029272472,
0.02383639,
0.033603687,
0.017024124,
0.02944572,
-0.00009576683,
-0.0009708458,
0.0038016622,
0.038990736,
0.0030432912,
0.012245079,
-0.028765801,
0.008113264,
-0.0170372,
0.0031299153,
0.0032247119,
-0.015075895,
-0.0048869173,
-0.0044586994,
0.024241725,
-0.015049744,
-0.012539275,
0.009211594,
0.027405964,
-0.012957687,
-0.015625061,
-0.012447747,
0.010715261,
0.010401453,
-0.0010166096,
-0.027327511,
-0.62217814,
-0.015167423,
0.020201439,
0.012735405,
-0.014082167,
0.035120428,
-0.004553496,
-0.01362453,
-0.0057335473,
0.012957687,
-0.02171818,
0.0050340155,
0.0140037155,
-0.042442635,
-0.010571432,
-0.017337933,
-0.0067011244,
0.0033832507,
0.029916434,
-0.010388377,
-0.009649619,
-0.016056547,
0.009538478,
0.006671705,
-0.04016752,
0.0017635397,
0.016435733,
-0.0035728433,
0.0032623035,
0.043540966,
-0.007629475,
0.011460557,
0.01503667,
-0.015873492,
0.044979256,
0.0014734302,
-0.0036120694,
0.03480662,
0.013925264,
0.025170077,
-0.0137422085,
-0.0031593349,
-0.0038735766,
-0.009826137,
-0.014395976,
0.028242787,
-0.0038768456,
0.024071746,
0.0009455123,
-0.015324327,
-0.0074398825,
-0.00004017099,
-0.036924828,
-0.014735936,
0.018959278,
0.0060408185,
0.023143396,
-0.00017120555,
0.0055079972,
0.011813592,
0.0043508275,
0.016684165,
-0.007825606,
-0.017377159,
-0.014291373,
-0.008570901,
-0.029131912,
-0.002984452,
0.009479639,
-0.00789752,
0.025235454,
0.029210364,
-0.008852022,
-0.0014056017,
-0.0077144653,
0.02242425,
-0.015938869,
0.02524853,
-0.010381839,
0.016043473,
-0.0050111334,
-0.007511797,
-0.02262038,
0.009793448,
0.017220255,
-0.002919075,
-0.009035077,
0.014879765,
-0.019076956,
0.01055182,
0.004834616,
0.016161151,
-0.019926855,
-0.045502268,
-0.026935251,
0.024686288,
-0.0016319689,
-0.008557826,
0.01635728,
-0.0113363415,
-0.0014750645,
0.0015240972,
0.011898582,
-0.004883649,
0.017730195,
-0.0035270795,
-0.04581608,
-0.0029648389,
0.052170705,
-0.017194105,
0.016226528,
-0.0033015294,
0.014945142,
-0.00640366,
0.01720718,
-0.006380778,
0.01937769,
0.024163274,
0.007949822,
-0.020175288,
0.038180064,
-0.005285716,
0.014304449,
-0.011552084,
0.0050340155,
0.0010108891,
-0.011382105,
0.00311684,
0.0047463574,
-0.020332191,
0.007629475,
0.0029092687,
0.010604121,
-0.020136062,
0.01771712,
0.013585304,
0.022581154,
0.018750073,
-0.008466299,
-0.024084821,
-0.03365599,
-0.020868283,
0.0053674374,
-0.006671705,
-0.015481232,
0.010793714,
0.004775777,
0.018828524,
0.01235622,
-0.005903527,
0.010885241,
0.0066324784,
-0.0051549627,
0.010519131,
0.022999566,
-0.0047398196,
-0.018697772,
-0.0065899836,
0.005622407,
-0.012611189,
-0.01937769,
0.0063742404,
0.006688049,
0.0049653696,
-0.012147014,
0.0063186698,
0.012140476,
0.010571432,
0.0047104,
-0.03870308,
0.014945142,
-0.024189424,
-0.021652803,
0.01246736,
0.003077614,
-0.006214067,
-0.006524607,
0.0034388208,
-0.006956094,
-0.0074594957,
0.0037493608,
-0.014042942,
0.012761556,
-0.0047104,
0.037918556,
0.012088175,
0.019194635,
-0.004037019,
0.0055243415,
0.03653257,
-0.014866689,
0.014762087,
-0.036820225,
0.016213452,
0.0035270795,
-0.026072277,
0.011100984,
0.013206118,
-0.006733813,
0.007426807,
-0.02617688,
-0.023901766,
0.011996647,
-0.02939342,
0.00072077947,
-0.019390766,
-0.009891514,
-0.027615169,
0.030753257,
-0.00221464,
0.009486177,
0.003322777,
0.003085786,
-0.010878704,
-0.0020299503,
0.015886568,
0.023326451,
-0.00140315,
0.0037755114,
-0.013062289,
0.0009708458,
-0.0029713765,
0.016958747,
-0.018828524,
-0.01308844,
0.024150198,
0.0011285674,
0.012133938,
-0.014644409,
-0.00933581,
-0.002101865,
-0.0069299433,
0.02471244,
0.016318055,
-0.0032884541,
0.0058773765,
-0.000090761416,
0.012323531,
0.034675866,
0.0075379475,
-0.010695648,
0.024973946,
-0.0044717747,
0.015245875,
-0.013663756,
-0.0019792833,
0.01630498,
-0.0062532932,
-0.0084793735,
0.017900174,
-0.0059590973,
-0.016370356,
-0.024437856,
-0.020672152,
-0.004896724,
-0.019403841,
0.010270699,
0.00012585039,
0.054759625,
0.015886568,
0.024633987,
-0.010571432,
0.023156472,
-0.030099489,
0.021051336,
0.01635728,
-0.012094712,
-0.018763147,
0.0025954598,
-0.00046499266,
-0.047934286,
0.0066324784,
0.029367268,
-0.03799701,
0.0068057273,
0.035120428,
-0.0027899558,
0.019469218,
0.014173695,
0.018187832,
-0.014056017,
-0.031407025,
0.02047602,
0.028033582,
-0.003004065,
-0.022201968,
-0.017677892,
-0.0049490253,
-0.006129077,
0.0057073967,
0.021456674,
0.00922467,
0.00930966,
0.01686722,
-0.0025644058,
0.000005749202,
0.025340056,
-0.010721799,
0.014461353,
0.0060244743,
-0.0052595655,
0.0033472932,
-0.002992624,
-0.009701921,
0.027092155,
-0.0065932525,
-0.009244283,
-0.020528322,
-0.018200908,
-0.024607835,
0.0012225466,
-0.012147014,
-0.01193127,
-0.031223971,
0.023574883,
0.015729664,
-0.00394876,
0.020750603,
0.012303918,
0.010545282,
-0.020868283,
-0.032086946,
0.015559684,
0.00832247,
0.019848403,
0.01633113,
-0.014932066,
0.014905916,
-0.010074568,
0.013519927,
-0.022607306,
-0.015664287,
0.033839043,
-0.011473632,
-0.011172899,
0.024503233,
-0.0038539637,
0.00060064957,
0.01156516,
0.028164335,
0.0058316127,
-0.026255332,
0.009538478,
0.0007166934,
0.0051549627,
0.012630803,
0.03043945,
0.028844254,
0.030256394,
-0.0098719,
-0.0035957252,
0.019273087,
-0.00078942516,
-0.01720718,
0.004978445,
0.02169203,
-0.012480436,
0.0042364183,
-0.0018305511,
-0.020096835,
-0.0012544178,
0.025601564,
0.007825606,
0.011813592,
0.02688295,
0.027196757,
0.016135,
0.002775246,
0.008767032,
-0.015102046,
0.011885506,
0.013859887,
0.008923937,
-0.01057797,
0.031302422,
-0.02366641,
-0.012192777,
-0.03946145,
0.004076245,
0.0013998812,
0.012885772,
0.0018125724,
-0.0061388835,
0.0046156035,
-0.008943549,
-0.020384494,
0.023117244,
-0.0037558984,
-0.016344206,
-0.009178906,
-0.007302591,
-0.008616665,
-0.040324423,
-0.00595256,
-0.011715527,
-0.014827464,
-0.038101614,
0.008799721,
0.006380778,
0.016906446,
0.014801312,
0.010257623,
0.001379451,
0.042808745,
-0.0074987216,
-0.01057797,
-0.0052562966,
-0.03436206,
0.009649619,
0.0049065305,
0.02101211,
-0.013768359,
-0.025549263,
-0.0107741,
-0.0020103373,
-0.008466299,
0.010715261,
-0.008806258,
-0.01176129,
0.014683634,
0.01540278,
0.021848934,
-0.0033195082,
-0.01596502,
-0.0323746,
-0.010630271,
-0.032505356,
-0.0050176713,
-0.0076033245,
-0.03509428,
0.0016703778,
0.013428399,
-0.0056126,
-0.0097803725,
-0.006357896,
-0.008427072,
-0.00097493187,
0.0017782496,
0.003726479,
0.04450854,
-0.005789118,
0.028975008,
0.006583446,
-0.011172899,
-0.019560745,
-0.026189955,
0.015468156,
0.0006983062,
-0.02276421,
0.018423188,
-0.0036741775,
-0.00815249,
-0.0033603688,
-0.02473859,
-0.014788237,
0.00930966,
0.0045142695,
-0.0045567644,
-0.03334218,
0.007740616,
-0.0063709714,
0.0037166723,
-0.009035077,
-0.022790361,
-0.013140742,
0.0128334705,
-0.0062042605,
-0.008335545,
0.02262038,
-0.0340744,
-0.007184913,
0.02795513,
-0.007904058,
0.026163805,
-0.0005704128,
0.0031331843,
-0.029654928,
-0.0057662358,
-0.017821722,
-0.04552842,
0.010904854,
-0.016161151,
0.044979256,
0.018763147,
0.023182621,
-0.031616233,
0.03297607,
0.01055182,
-0.0070083956,
-0.007341817,
-0.00059166027,
0.028739652,
-0.004256031,
-0.014016791,
-0.0016221624,
-0.010767562,
0.010832939,
-0.004998058,
0.0013377733,
0.012761556,
-0.009106992,
-0.008812795,
-0.0046254103,
-0.013199581,
-0.041030493,
0.0154289305,
-0.0066749738,
-0.0068645664,
-0.018187832,
-0.00069462875,
0.029158063,
-0.0014693441,
0.009662694,
-0.003974911,
0.014409052,
-0.020855207,
0.028556596,
-0.021783557,
0.008878172,
-0.005723741,
-0.028295089,
-0.0077210027,
-0.01503667,
0.024803966,
0.011963959,
-0.015350478,
0.010917929,
-0.0018452608,
0.00840746,
0.006858029,
-0.01540278,
-0.010381839,
-0.030988613,
-0.013121128,
-0.031746984,
-0.035120428,
-0.030282544,
-0.005001327,
0.016318055,
0.011545547,
0.0014758818,
0.030700956,
-0.016684165,
-0.023404902,
0.033551384,
-0.0025693092,
0.027039854,
-0.027405964,
0.010793714,
0.010133407,
0.00043230425,
-0.009597317,
-0.0060440875,
-0.00908084,
-0.015651211,
0.027510567,
0.027615169,
-0.02651684,
-0.016540335,
0.0027360201,
0.0061650346,
0.009969966,
-0.020763678,
0.011172899,
-0.0065474887,
-0.0024107704,
-0.01540278,
-0.017730195,
-0.015847342,
0.014461353,
-0.030622505,
0.006665167,
0.0071914503,
-0.010133407,
0.012755018,
0.024555534,
-0.0029076342,
0.012558888,
-0.023601033,
-0.026752196,
0.018514717,
-0.02944572,
-0.0032394216,
-0.025549263,
-0.0026510302,
0.029341118,
0.016514186,
0.013663756,
0.0045567644,
-0.0042723753,
0.0104276035,
-0.0025284486,
-0.015546609,
0.049451027,
-0.007341817,
0.0034257455,
-0.0014987637,
-0.0041056643,
-0.013833736,
-0.004321408,
-0.017874023,
-0.012813857,
-0.02668682,
0.009623468,
0.039016888,
-0.010192247,
-0.010839477,
0.0042527625,
-0.028138185,
-0.0042298804,
-0.032740712,
-0.017520988,
0.015167423,
-0.03697713,
-0.0066520916,
0.008701655,
-0.008204792,
0.026961401,
0.021260543,
0.0223981,
-0.012656953,
0.025130851,
-0.03198234,
0.012160089,
0.0012012991,
0.014788237,
-0.0075444854,
-0.012526199,
-0.0053445552,
-0.042102672,
-0.009969966,
-0.0033897883,
-0.026778346,
-0.02298649,
-0.00041514283,
-0.00075959694,
0.009460026,
-0.022175819,
0.041422755,
-0.0058675697,
0.018593168,
0.004148159,
-0.012905384,
0.020489097,
-0.0068253404,
-0.01720718,
0.022698833,
0.0066749738,
0.0003027764,
0.025483886,
-0.0013614723,
-0.005373975,
0.009427338,
-0.010813327,
-0.023614109,
-0.0010231473,
-0.013506851,
0.0035009289,
-0.015925795,
0.006240218,
-0.0011555353,
0.0034257455,
0.010931005,
-0.006645554,
0.006570371,
0.0013998812,
0.014330599,
0.013134204,
-0.016710317,
-0.0033701751,
0.008904323,
-0.0067665013,
-0.023980219,
-0.007237214,
-0.051830746,
0.036061857,
-0.0119247325,
0.018580092,
-0.008244017,
0.007962897,
-0.038546175,
-0.016213452,
0.018174756,
0.007936746,
0.01667109,
0.020214513,
-0.00036999196,
0.008485911,
-0.0112252,
-0.00086951174,
-0.0013246979,
-0.03300222,
0.007197988,
-0.0008037263,
0.025418509,
0.01576889,
-0.015376628,
-0.022881888,
0.0467052,
-0.021273619,
-0.010198784,
0.03127627,
-0.020018384,
0.0044096666,
-0.0018354543,
-0.002459803,
-0.015376628,
0.011826667,
0.025457734,
-0.0082832435,
0.009754222,
0.014801312,
-0.016736466,
-0.017834798,
-0.011852818,
0.019979157,
0.0030645386,
0.016788768,
-0.014500579,
-0.019403841,
0.02044987,
-0.023208773,
0.015625061,
0.0025660403,
-0.01334341,
0.0089697,
0.0023846196,
-0.027798224,
-0.016605712,
-0.004386785,
-0.009303122,
0.021822784,
-0.015690437,
-0.008832409,
-0.022267345,
0.009146217,
-0.011414793,
-0.023927918,
0.015834266,
-0.031616233,
0.016095774,
-0.041004345,
0.005622407,
0.00032954005,
-0.026987553,
-0.00578258,
-0.009486177,
-0.027536718,
-0.021508975,
-0.00038735766,
0.015180498,
-0.021312844,
-0.0057106656,
0.0036512956,
-0.0012813858,
0.0052530277,
-0.000022652048,
0.00010158945,
-0.013506851,
0.004216805,
0.19215555,
-0.045946833,
-0.011094447,
0.00059860654,
-0.01681492,
0.007577174,
-0.0026493957,
0.00029072256,
-0.009139679,
-0.008191716,
0.031067066,
0.013402249,
0.0043475586,
0.004543689,
0.007243752,
-0.011983572,
-0.0197438,
-0.012153551,
-0.021652803,
-0.0069364808,
0.012983837,
0.0044685057,
-0.009067765,
-0.0021786827,
0.04155351,
0.00795636,
-0.038859982,
0.016566487,
0.030256394,
-0.0022669414,
-0.034492813,
0.013147279,
0.0075837113,
-0.004403129,
0.009067765,
0.015415855,
-0.008714731,
-0.009440414,
0.018462414,
0.006521338,
0.006295788,
-0.019024655,
-0.008721268,
0.0018583362,
0.021744331,
0.017965551,
-0.0016066354,
-0.016932597,
-0.009819599,
0.014134469,
-0.021744331,
-0.0032426903,
-0.0056975903,
0.015088971,
0.016265754,
-0.022633456,
0.02237195,
0.013101515,
-0.0040631695,
0.015285101,
-0.025379283,
-0.00071138155,
-0.030570202,
0.037918556,
-0.009152755,
0.020502172,
-0.010878704,
0.023064943,
0.010153021,
-0.026333785,
-0.002724579,
0.011460557,
-0.01852779,
-0.0040631695,
-0.014212921,
-0.0069234055,
0.020031458,
-0.006557295,
0.023378752,
0.0069299433,
-0.0060179364,
0.013251882,
-0.012218928,
0.009636544,
0.0056322133,
-0.022921113,
0.018030928,
-0.0054230075,
-0.021051336,
-0.0012936438,
-0.0037591674,
-0.012009722,
-0.0021819514,
-0.009492715,
0.023587957,
-0.014382901,
0.005171307,
-0.018266285,
-0.004197192,
-0.039304547,
-0.030387146,
0.09539786,
-0.004275644,
-0.0052530277,
-0.018488565,
0.03441436,
0.002654299,
0.0010819865,
0.014317525,
-0.0013671928,
0.019116184,
-0.01582119,
0.013833736,
0.01165015,
-0.015978096,
0.005226877,
0.021639729,
-0.012140476,
0.022071216,
-0.0032786475,
-0.0064134663,
-0.010937543,
0.0049522943,
0.02434633,
-0.013964489,
0.016213452,
-0.029001158,
0.006792652,
-0.0010443948,
-0.021600502,
-0.009839212,
0.0049621006,
0.0032737444,
0.024973946,
0.014147544,
0.0024009638,
0.013467626,
-0.024973946,
-0.04087359,
0.0023552,
-0.0010354054,
0.00009183401,
0.018044002,
-0.0016491304,
-0.00860359,
-0.00081516727,
0.032793015,
0.020175288,
-0.027510567,
0.006027743,
-0.013533003,
-0.023731787,
-0.021025186,
-0.0043933224,
0.01635728,
-0.01681492,
-0.017560214,
0.0014783334,
0.0063873157,
0.019861478,
-0.030727107,
-0.003762436,
-0.0017700775,
-0.012447747,
0.011395181,
-0.0072502894,
-0.1617161,
0.009734609,
0.01582119,
-0.020698301,
0.03015179,
0.010166096,
-0.022777285,
-0.0015592373,
-0.009930739,
0.013519927,
0.041187398,
0.0067011244,
-0.03127627,
0.0039193407,
0.003909534,
0.009950353,
-0.0024205768,
0.03506813,
0.011512859,
0.016553411,
0.023614109,
-0.019704575,
-0.0077144653,
-0.01210125,
0.010695648,
0.008897786,
0.012022798,
-0.010643347,
0.0051974575,
-0.026163805,
-0.02047602,
0.014840539,
0.02564079,
-0.0055308794,
0.04055978,
0.0054197386,
0.008119801,
-0.021456674,
0.009747684,
0.028844254,
0.04048133,
0.008505525,
0.009237745,
0.0020185094,
-0.019142333,
0.026438387,
-0.0115324715,
-0.0057335473,
0.015899643,
-0.018906977,
0.018331662,
-0.021979688,
-0.009564629,
0.020384494,
0.026621442,
0.032086946,
0.0027932248,
0.017900174,
-0.007348355,
0.010957155,
-0.018044002,
0.0028847523,
0.020999035,
-0.0016662917,
0.010355689,
-0.008132877,
-0.0033080673,
0.020842131,
-0.0068776417,
0.0073156664,
-0.030674806,
-0.024777817,
0.024241725,
-0.016592637,
0.008329007,
0.022267345,
-0.006858029,
-0.011264427,
0.003621876,
-0.007139149,
-0.002984452,
0.007904058,
-0.025863072,
-0.0022522316,
-0.032583807,
0.001853433,
0.0069691692,
0.022385024,
0.003909534,
-0.0031920234,
0.011460557,
-0.022241196,
-0.0024238457,
-0.030936312,
0.014252148,
0.030308696,
-0.016252678,
-0.008159027,
-0.017795572,
0.005883914,
-0.0005062618,
-0.019312313,
-0.003912803,
0.0029664733,
-0.0004527345,
-0.020384494,
-0.026072277,
-0.0066324784,
0.031877737,
-0.01725948,
0.011519396,
0.007204526,
0.008355158,
0.017429462,
-0.0000030374047,
-0.0041252775,
0.0018240133,
0.009558092,
-0.007426807,
-0.028661199,
0.07275133,
0.014579032,
-0.0071652997,
0.018213984,
0.00014331825,
-0.02578462,
-0.14027251,
-0.0022587692,
0.017821722,
-0.0121797025,
-0.020502172,
0.01582119,
-0.0047463574,
0.019769952,
-0.021051336,
0.015389704,
-0.023431053,
0.014997443,
-0.019338464,
-0.037918556,
-0.009898051,
-0.012800782,
0.007073772,
-0.01469671,
-0.019796101,
0.034754317,
0.0094534885,
-0.02171818,
-0.008714731,
-0.01472286,
0.015219725,
-0.008374771,
-0.03585265,
0.03271456,
-0.0032574001,
0.0014644408,
-0.003683984,
-0.01525895,
0.023875616,
0.0011726967,
-0.01503667,
0.0027801495,
0.007309129,
-0.021116713,
0.048640355,
0.012990375,
0.009819599,
0.018200908,
0.005759698,
-0.01040799,
-0.0076229377,
-0.011545547,
-0.034675866,
0.014958217,
0.02578462,
-0.003291723,
-0.028870406,
-0.037840106,
-0.045842227,
0.002584019,
0.016592637,
0.009244283,
-0.016618788,
0.028922707,
-0.016200377,
0.001251149,
0.016121924,
-0.009701921,
0.01317343,
0.016344206,
0.027798224,
-0.033499084,
0.007819068,
-0.010218398,
0.023784088,
-0.03227,
0.0060963887,
-0.02530083,
0.00039246524,
0.001255235,
-0.0068711042,
0.019665347,
-0.015141272,
-0.014186771,
-0.001962939,
-0.015468156,
-0.02544466,
-0.0056126,
0.01582119,
-0.008420534,
0.042076524,
-0.010414528,
0.000089382374,
0.014225997,
0.006619403,
-0.0041808477,
-0.013264957,
0.035486538,
0.008583977,
0.002541524,
-0.021234391,
0.019939931,
0.0035466927,
0.00093325414,
0.01576889,
0.020868283,
-0.0055864495,
-0.009093916,
-0.058682237,
0.025235454,
-0.019429991,
0.012539275,
0.01576889,
-0.030387146,
0.024189424,
-0.041527357,
0.010388377,
0.037447844,
-0.011218662,
0.010983306,
0.0010198784,
0.01435675,
-0.030360997,
-0.042834893,
0.025941523,
-0.0074856463,
0.018030928,
0.037473995,
0.0029664733,
-0.015180498,
0.015389704,
0.027458265,
-0.0073745055,
0.0074202693,
-0.006691318,
0.020829055,
-0.01119905,
-0.0011105888,
-0.0030220437,
-0.040612083,
-0.016226528,
-0.0031871202,
-0.030753257,
-0.02795513,
-0.0070476215,
0.025457734,
0.018436264,
0.022581154,
-0.012513123,
-0.03974911,
0.006733813,
-0.017756345,
0.0019400573,
-0.02366641,
-0.039356846,
0.018540867,
0.0004192289,
-0.024594761,
0.04050748,
-0.005491653,
-0.0077733044,
-0.03870308,
-0.002078983,
0.022345798,
0.023051867,
-0.023954067,
-0.002098596,
-0.015873492,
0.010061493,
0.03381289,
0.01952152,
0.018684696,
0.0077667665,
-0.011682838,
-0.02727521,
0.02352258,
-0.0141998455,
-0.010336076,
-0.015834266,
0.02349643,
-0.00048869173,
-0.00275073,
0.022711908,
0.0046613673,
-0.0061977226,
0.008642816,
-0.041108947,
0.015651211,
0.00077921,
-0.0128334705,
-0.021783557,
0.0046319477,
0.03525118,
0.007302591,
-0.009884976,
0.006119271,
0.014474428,
0.000012583761,
-0.010957155,
0.01813553,
0.0154289305,
0.029994886,
0.029733378,
0.015324327,
0.010022267,
0.007014933,
0.00465483,
0.028295089,
0.022162743,
-0.01861932,
-0.00037040055,
-0.023718711,
0.011192512,
0.038912285,
-0.040062916,
-0.05554415,
-0.017416386,
0.014317525,
0.0037591674,
0.014500579,
-0.01345455,
0.0029632044,
-0.028425843,
0.024607835,
-0.0009299853,
0.0010484807,
-0.0043083327,
0.024947796,
0.008714731,
0.0136114545,
0.0006366068,
-0.007917133,
0.0057106656,
-0.00044088493,
0.029916434,
-0.026621442,
0.012643877,
0.0035434237,
0.008224404,
0.0057564294,
-0.041422755,
0.0016540337,
0.00043230425,
-0.01489284,
0.0045731086,
0.046835955,
-0.030308696,
0.07233292,
0.015559684,
-0.0053020604,
-0.00044129355,
-0.031511627,
0.024503233,
0.023483355,
0.028112033,
-0.0010010826,
-0.032086946,
0.034754317,
0.010421066,
0.01599117,
-0.03551269,
-0.046835955,
0.01864547,
-0.0011048682,
-0.010002654,
0.007139149,
-0.020829055,
0.007936746,
-0.008806258,
0.0038245441,
-0.0070280083,
-0.03234845,
-0.003726479,
0.030413298,
-0.012003184,
-0.00082374795,
-0.033132974,
0.023365676,
-0.007400656,
-0.041318152,
-0.0019416916,
0.0052334145,
-0.01579504,
-0.0304656,
-0.028504295,
-0.0053608995,
0.008374771,
0.0011702451,
0.012630803,
-0.03164238,
-0.0121274,
0.019024655,
-0.02110364,
-0.012388908,
-0.012205853,
0.0019449604
] |
Strategies to prevent organ transplant rejection whilst minimizing long-term immunosuppression are currently under intense investigation with regulatory T cells (Tregs) nearing clinical application. The clinical trial, ThRIL, recently commenced at King's College London, proposes to use Treg cell therapy to induce tolerance in liver transplant recipients, the success of which has the potential to revolutionize the management of these patients and enable a future of drug-free transplants. This is the first report of the manufacture of clinical grade Tregs from prospective liver transplant recipients via a CliniMACS-based GMP isolation technique and expanded using anti-CD3/CD28 beads
|
[
-0.00399478,
-0.0024210273,
0.0057914103,
-0.025098382,
-0.008023588,
0.011766568,
-0.034163196,
0.020184869,
-0.02572448,
-0.01360403,
-0.0058628675,
-0.026677238,
0.007846647,
0.0005708044,
0.0010012471,
0.007329435,
0.03748424,
-0.009704526,
0.0022968284,
-0.0007081888,
-0.014863033,
-0.006665907,
-0.017163264,
0.004369078,
-0.010187711,
-0.0005001982,
0.03595983,
-0.041839708,
-0.0069006938,
-0.013808193,
0.0030301122,
-0.012501553,
-0.014304988,
0.004818236,
-0.0013270564,
-0.03647704,
0.0126648825,
-0.0024754708,
0.022866204,
0.015067195,
0.031985465,
0.0027800133,
0.006172514,
0.0048658736,
-0.0004240626,
0.019327387,
0.014250545,
-0.02557476,
-0.0068666665,
0.019409051,
0.021409845,
0.011453518,
-0.004695738,
0.009173703,
-0.014291378,
-0.0032529896,
-0.018116022,
0.026731681,
0.0059207133,
-0.026826957,
-0.015883844,
0.0034877767,
-0.019300165,
-0.0012564503,
0.022580376,
0.032393787,
-0.017312983,
0.008241361,
-0.00085663196,
-0.018156854,
0.017939081,
0.02820165,
-0.002865081,
-0.013923884,
0.020715691,
-0.01709521,
-0.0117053185,
0.0067509743,
0.00295185,
0.0011382061,
0.021151239,
-0.010827419,
-0.0018697885,
0.033237662,
0.011712124,
0.008037198,
0.006733961,
0.018047968,
0.015938288,
-0.009554806,
0.013692501,
0.031822134,
0.011548794,
0.034163196,
-0.018959895,
0.005131285,
0.0052435743,
0.03977086,
-0.018755732,
-0.039879747,
0.010065213,
-0.0073362403,
-0.005457945,
-0.017299373,
-0.04725682,
0.0121000325,
0.0066999337,
0.004675322,
0.017762141,
-0.008561215,
-0.029943839,
0.049107894,
-0.012270168,
-0.013787776,
0.024118401,
0.008425107,
0.018987115,
0.01614245,
-0.010432705,
-0.0224851,
0.02458117,
0.0039369343,
0.016496332,
-0.020484308,
0.011875454,
0.03163158,
-0.0062133465,
-0.0026319954,
-0.020770134,
0.012712521,
0.020729303,
-0.008411496,
-0.012025173,
0.032176014,
-0.004369078,
0.01693188,
-0.020634027,
0.015502742,
-0.015053584,
-0.027711662,
-0.021722894,
0.019191278,
-0.0046481006,
0.011514767,
-0.005631483,
-0.0025622398,
0.015380244,
0.010432705,
0.00020650189,
-0.00038067804,
-0.0132773705,
-0.012304195,
0.018374627,
0.0038790882,
0.015012751,
-0.0007315824,
-0.008989957,
0.014522761,
-0.016482722,
-0.007941922,
0.0036511067,
-0.040015858,
0.017489923,
0.0036919392,
0.023369804,
0.0057573835,
0.0047433763,
0.035551503,
0.0075131813,
-0.0010165593,
-0.0006333292,
0.028854972,
-0.027575552,
0.009568417,
0.002606475,
0.016033564,
-0.014386653,
0.0038620746,
-0.01171893,
-0.016863825,
-0.016006343,
0.032475453,
0.014536372,
0.025071159,
-0.021886224,
0.0090035675,
0.01287585,
-0.0009901883,
-0.0028871985,
-0.020565972,
0.0021181863,
0.010296597,
-0.007601652,
-0.043718003,
-0.6328494,
-0.033782095,
0.03092382,
0.00092893955,
0.018810175,
0.026010307,
0.029426627,
-0.026200859,
-0.047501817,
0.014277766,
0.013100429,
0.024676444,
0.022580376,
-0.02183178,
-0.008078031,
-0.025955863,
-0.012637661,
-0.002717063,
0.041159168,
-0.017204097,
-0.0077717872,
-0.013311397,
-0.002875289,
0.02213122,
0.009554806,
0.007098051,
0.014046382,
-0.0048284438,
-0.01629217,
0.018292964,
-0.0027851171,
-0.00067884044,
-0.007928312,
0.006910902,
0.055450544,
0.0007856004,
-0.032666005,
0.0035728444,
-0.0006796911,
0.025833366,
-0.0019140238,
-0.0027442847,
0.04529686,
-0.00043767344,
-0.013488338,
0.01807519,
0.018184077,
-0.003033515,
-0.0034537495,
-0.0043963,
0.00145721,
0.0144955395,
-0.010303402,
0.022240106,
0.019327387,
-0.009854245,
0.039199207,
0.0071933265,
0.012957515,
0.001639255,
-0.026854178,
0.02607836,
-0.021913445,
-0.024118401,
0.0044609513,
0.004018599,
-0.0059921704,
0.0075540137,
0.03078771,
0.016686885,
0.005961546,
0.017612422,
-0.012658077,
-0.0050121904,
0.0027034522,
0.029862173,
-0.009030789,
-0.016047176,
0.011875454,
0.016156062,
-0.0056893295,
-0.0061520976,
-0.006383482,
0.014386653,
0.034680407,
-0.0024414437,
-0.0048964983,
0.007921507,
-0.007833036,
0.01825213,
0.008105253,
-0.0071116616,
-0.0050258012,
-0.030597158,
-0.007948728,
0.030542715,
-0.012835018,
-0.010282986,
0.026908621,
-0.0027629996,
0.0014597621,
-0.008472745,
0.011201718,
-0.0012037082,
0.010412289,
-0.009670499,
-0.051394515,
0.011426296,
0.04317357,
-0.03503429,
0.0047876113,
0.010977139,
-0.01889184,
-0.008568021,
0.014781367,
-0.020212092,
0.01035104,
0.012732937,
-0.0051040635,
-0.035878163,
0.04644017,
-0.015897457,
0.017449092,
0.012202114,
0.006216749,
0.00042640197,
0.00646855,
0.0049339277,
0.007601652,
0.015693294,
-0.0063732737,
-0.0043792864,
0.025819754,
-0.017530756,
0.029453848,
-0.011616848,
0.026200859,
0.00080133794,
-0.0111404685,
-0.018674066,
-0.020919854,
-0.015529963,
0.016795771,
0.010983944,
-0.017925471,
-0.0059683514,
0.0055225966,
-0.00065714814,
-0.0011194912,
-0.020416254,
0.005845854,
-0.002754493,
-0.00016832775,
-0.014618037,
0.013216121,
-0.00327851,
-0.013311397,
-0.045215197,
0.0018034357,
-0.018674066,
-0.012331417,
0.024240898,
-0.005478361,
-0.00018853134,
-0.016891047,
-0.019232111,
0.007833036,
0.009459531,
-0.02508477,
-0.038055897,
-0.023764519,
-0.036041494,
-0.0224851,
0.030243278,
-0.001697101,
0.0014214816,
-0.016482722,
-0.01547552,
0.018810175,
0.0069347206,
-0.021137627,
-0.019654047,
-0.00095190783,
0.006924513,
-0.0014725223,
-0.0020195078,
0.003787215,
0.006580839,
0.009017179,
0.03481652,
-0.0257517,
0.0018731912,
-0.01173254,
0.033155996,
0.006437925,
-0.008397886,
-0.011487545,
0.009827023,
0.009037595,
0.010446317,
-0.0010233647,
-0.021219293,
0.029045522,
-0.029916616,
0.006917707,
-0.021314569,
0.003344863,
-0.015598018,
0.0063188304,
0.014427486,
-0.021450676,
-0.0009604146,
-0.018919062,
-0.018224908,
0.013032375,
0.026173636,
0.005151701,
-0.00960925,
0.0013551288,
-0.028882192,
0.0030692434,
-0.00262519,
0.01465887,
-0.0076152626,
-0.022076776,
0.014427486,
0.010385067,
-0.014645259,
0.007002775,
-0.01825213,
-0.024009515,
-0.02200872,
0.001818748,
0.005947935,
0.012358638,
0.025370598,
0.0033125372,
-0.017381037,
0.026840568,
0.0069585396,
0.0077105383,
0.017149653,
-0.00022542947,
0.007962339,
-0.012685299,
-0.015652461,
0.022403436,
0.011133663,
0.002126693,
0.030188832,
-0.015162471,
0.028065544,
-0.017762141,
-0.017217707,
0.017013544,
-0.0042397752,
0.0118074,
0.013467922,
0.047447372,
0.013386257,
0.025465874,
0.015529963,
0.0010063512,
-0.029290518,
-0.0042976215,
0.017476313,
0.022199273,
0.00038004006,
-0.02428173,
-0.0040968615,
-0.021369012,
-0.009622861,
0.02639141,
-0.030842153,
0.004222762,
0.035578724,
0.014971919,
-0.0015303683,
0.013780971,
-0.014767757,
-0.008921903,
-0.03307433,
0.012358638,
0.02441784,
-0.008568021,
-0.017136041,
-0.023070367,
-0.008506772,
0.0060364055,
0.0062575815,
0.0071797157,
0.011610042,
0.017054377,
0.00797595,
0.00027689544,
-0.03176769,
0.03242101,
0.0005912207,
0.007268186,
-0.025098382,
0.008908292,
-0.015843013,
-0.0121000325,
-0.033319324,
0.0175852,
0.003600066,
-0.008282194,
-0.029998282,
-0.008928708,
-0.0027987282,
-0.010248959,
0.003431632,
0.008357053,
-0.027861381,
0.0031424016,
0.012903072,
-0.0056484966,
0.028800528,
0.008499967,
-0.0047399737,
-0.0063800793,
-0.018224908,
-0.0011501156,
-0.0003249587,
0.037565906,
-0.01295071,
0.012807797,
0.027548332,
-0.0046821274,
0.000052263484,
0.005022398,
-0.042275254,
0.027167227,
-0.00008097384,
-0.016196894,
0.0062677898,
0.002553733,
0.014726924,
0.013311397,
0.026636405,
-0.006080641,
-0.009582028,
-0.01644189,
0.004185332,
0.018483514,
-0.0074042943,
0.023737296,
0.015516353,
0.025384208,
-0.006802015,
0.024390617,
0.023397027,
-0.00043682277,
0.002169227,
0.005053023,
0.0016596713,
0.0067611826,
0.00054230675,
0.01710882,
-0.021287346,
0.007601652,
-0.0024669638,
0.008241361,
-0.00022670548,
0.006359663,
0.029099967,
0.019327387,
-0.012426693,
0.0068088206,
-0.031985465,
-0.0024992896,
0.015774958,
-0.016795771,
-0.03598705,
0.019790156,
-0.008513577,
-0.024540337,
-0.022621209,
0.0022866204,
0.012304195,
-0.015679682,
-0.009650082,
0.0005499628,
-0.0037259662,
0.018633233,
-0.038872547,
0.0041513047,
0.0070572183,
-0.02083819,
-0.0039539477,
-0.011460324,
-0.020429865,
-0.026963064,
-0.0164555,
0.010602841,
-0.012351833,
-0.0040049884,
0.037212025,
-0.00011005637,
-0.021872614,
0.029208854,
0.0021641229,
0.023887016,
0.039634753,
-0.0023989098,
0.0030794516,
0.0064923684,
-0.028637199,
0.0012998348,
-0.005563429,
0.020783747,
-0.0038042285,
-0.016646052,
0.0030607367,
-0.0066761146,
-0.0024703667,
0.010412289,
0.009513974,
-0.011759762,
-0.0073770727,
0.034299307,
0.0042703995,
-0.00978619,
-0.013740138,
-0.045024645,
-0.011249356,
-0.014413875,
-0.008241361,
-0.006767988,
-0.0073158243,
0.0076424843,
-0.004079848,
0.0013423687,
-0.0280111,
0.016251337,
-0.0028310537,
-0.002529914,
-0.0041308887,
0.0030352164,
0.007397489,
-0.00928259,
0.0091328705,
0.016469112,
-0.009867855,
-0.028119987,
-0.00370555,
0.018592402,
-0.0033278493,
-0.013256954,
-0.012746547,
-0.013849026,
0.016863825,
-0.0280111,
-0.0059037,
-0.020130426,
0.025152825,
-0.005144896,
-0.018020747,
-0.032121573,
-0.004593657,
-0.006849653,
0.017489923,
0.008976346,
-0.016074397,
-0.020212092,
0.013542782,
-0.0090444,
0.0040764455,
0.016019953,
-0.028228873,
-0.008486356,
0.019082392,
0.0029637595,
0.0059411298,
0.004675322,
-0.013488338,
-0.02101513,
0.013359035,
-0.021736505,
-0.046004623,
-0.0093098115,
-0.035742056,
0.040805284,
0.026309745,
0.02686779,
-0.00978619,
0.01124255,
0.0031747273,
0.017911859,
0.0064855632,
-0.003028411,
0.023260918,
-0.016904658,
-0.0013849025,
-0.0048114303,
-0.015625238,
0.0031985464,
-0.020416254,
-0.0065774363,
0.012467525,
-0.0032019492,
-0.0075676246,
0.009343838,
-0.024200065,
-0.039553087,
0.007751371,
-0.006308622,
0.010766171,
-0.02083819,
0.0030913611,
0.009493558,
0.025016716,
0.019477107,
0.018047968,
0.021464288,
-0.026541129,
-0.0071116616,
-0.0038654774,
-0.0011365048,
-0.0042874133,
-0.013290981,
-0.010766171,
-0.02980773,
0.020593194,
0.00839108,
0.005127882,
0.016169673,
-0.0075608194,
0.0014504046,
0.0049033035,
-0.033292104,
-0.008533994,
-0.01840185,
-0.032176014,
0.0026490088,
0.01400555,
0.0047365706,
-0.020171259,
-0.011433102,
-0.0005469855,
0.00177111,
0.0127533525,
-0.025942253,
-0.004573241,
0.02132818,
0.0017881235,
0.017340204,
-0.0064243143,
0.0046583083,
0.02002154,
0.011038388,
-0.031849355,
-0.021355402,
-0.0035388172,
-0.017367426,
0.04254747,
0.032611564,
-0.014944698,
-0.030488271,
0.008241361,
0.012630856,
-0.04426244,
-0.033836536,
-0.004930525,
0.009418698,
-0.0093098115,
-0.028718863,
-0.023083977,
-0.024880607,
0.013427089,
0.0065706307,
-0.0055123884,
-0.0026422034,
-0.010841031,
-0.015516353,
0.014345821,
-0.01727215,
-0.003987975,
-0.0018970103,
-0.0280111,
0.0047876113,
-0.036531482,
-0.013964717,
0.0006864965,
0.013297786,
0.015298579,
0.016496332,
-0.0036136769,
0.030188832,
-0.018497126,
0.014686092,
-0.0120115625,
-0.002290023,
0.038028676,
0.011950314,
0.0043282458,
0.023356194,
0.0035966632,
-0.001697101,
-0.030188832,
-0.00015142055,
0.013209316,
-0.019667657,
-0.009874661,
0.031304922,
0.02753472,
-0.01710882,
0.007472349,
-0.017381037,
-0.013270564,
-0.0063052196,
-0.016564388,
0.017353816,
-0.029344961,
0.007479154,
0.0046310867,
-0.009827023,
0.0006830938,
-0.022076776,
0.017966302,
0.0030726462,
0.041322496,
-0.019953486,
0.009126065,
0.011800595,
0.0074519324,
-0.0015848117,
0.008186918,
0.0049271225,
-0.03538817,
0.0068666665,
-0.016754938,
-0.029344961,
-0.016482722,
0.004056029,
-0.010140073,
-0.014059993,
-0.004818236,
-0.0020841593,
0.023982292,
0.0296444,
0.016319392,
-0.004671919,
0.036994252,
-0.017476313,
-0.013685695,
0.008989957,
-0.015870234,
0.021545952,
0.01825213,
0.003038619,
0.011691708,
-0.017762141,
-0.014155269,
-0.007799009,
0.021464288,
-0.032012686,
-0.004266997,
-0.013372646,
0.004362273,
-0.008336637,
0.001396812,
0.024308952,
-0.0070504127,
-0.009881467,
0.010534787,
0.0022576973,
0.016972711,
-0.021300958,
0.016319392,
0.002553733,
-0.013903469,
-0.038681995,
0.0035592336,
-0.014209712,
0.045569077,
0.0048964983,
-0.013386257,
-0.018129634,
0.0086973235,
-0.057546612,
-0.0023972085,
0.020947076,
0.030842153,
-0.0024329368,
0.014209712,
0.013168483,
0.021532342,
-0.022580376,
0.011045193,
0.004862471,
-0.018660456,
0.034925405,
-0.02229455,
0.030760488,
0.018810175,
-0.057111066,
-0.018361017,
0.04769237,
0.00063375453,
0.009806607,
0.032666005,
0.0030471259,
0.034680407,
-0.015407466,
0.0065638255,
-0.03601427,
0.0071797157,
0.012433498,
-0.03277489,
0.013787776,
0.037212025,
-0.005342253,
0.0017090106,
-0.0067509743,
0.0073226294,
0.015734127,
0.0013857532,
-0.009377866,
-0.009486753,
0.006284803,
-0.009377866,
0.015489131,
0.008874265,
0.0007115915,
-0.005951338,
-0.0028616781,
-0.015421077,
-0.0008676908,
0.005219755,
0.009493558,
0.0011628758,
-0.0032478857,
-0.01612884,
0.008357053,
0.014059993,
-0.014073604,
-0.008928708,
-0.015135249,
0.004505187,
0.00798956,
-0.015244136,
0.014577205,
0.04981566,
-0.019803766,
-0.014767757,
0.010725338,
-0.017081598,
-0.019899042,
-0.0073158243,
0.006417509,
-0.007948728,
-0.016863825,
-0.0017472911,
-0.011188107,
-0.0046549058,
0.003773604,
-0.022389825,
-0.0017268747,
0.013740138,
0.19882709,
-0.030243278,
0.0033193426,
-0.0042567886,
0.00919412,
-0.002337661,
0.018102411,
-0.0034435415,
-0.021232903,
0.024145622,
0.011467129,
-0.020116815,
-0.012991543,
-0.009411893,
0.0027306739,
-0.019463494,
-0.027112784,
-0.021396233,
-0.023056755,
-0.014958308,
0.004062834,
0.014359431,
0.016673274,
-0.0057880078,
0.03832811,
0.0007860258,
0.0021743309,
0.022566766,
0.021940667,
-0.008928708,
-0.026173636,
0.0031662206,
0.0042874133,
0.00028667823,
0.019830987,
-0.005039412,
-0.0112289395,
-0.014209712,
0.010419095,
-0.00606703,
-0.014373043,
0.00295185,
-0.014917476,
-0.0032121572,
0.020334588,
0.038409777,
0.012072811,
0.0025214073,
0.0037463824,
-0.025806144,
-0.040369738,
0.005304823,
0.037511464,
0.029372184,
0.028582755,
-0.00023925297,
0.024172844,
0.016646052,
0.007921507,
0.014604427,
-0.023887016,
-0.0058016186,
-0.03225768,
0.041513048,
-0.0057097455,
0.021682061,
-0.03141381,
0.005270796,
0.010786587,
-0.013889858,
-0.0144547075,
-0.008404691,
-0.013903469,
-0.007070829,
-0.016006343,
-0.020647638,
0.010779782,
0.015502742,
-0.00010372946,
0.016401056,
0.00096977205,
0.0024839775,
-0.0084387185,
0.0049713575,
0.00059675006,
-0.026255302,
0.018782953,
0.009228147,
-0.022580376,
0.009704526,
-0.00871774,
0.0063868845,
-0.020960687,
-0.01514886,
0.025111992,
-0.00406964,
0.00051465974,
0.016333003,
-0.015353022,
-0.020484308,
-0.03827367,
0.05879881,
0.006043211,
0.012807797,
-0.0096568875,
0.028119987,
0.0061997357,
-0.0025690452,
-0.011324215,
-0.011392269,
0.022035943,
-0.03272045,
0.0159519,
-0.009418698,
0.006437925,
0.04611351,
0.008853848,
-0.0090035675,
0.021872614,
-0.000038253893,
0.014754145,
-0.012311,
0.00066522957,
0.009840634,
-0.025234489,
0.019259332,
-0.030052725,
0.000832813,
-0.010827419,
-0.018592402,
-0.0037599932,
-0.009452726,
-0.0041104723,
0.021287346,
0.009881467,
-0.021246515,
-0.004382689,
-0.024513114,
-0.029834952,
0.016714105,
0.0003402709,
-0.010255764,
-0.014645259,
-0.012018368,
0.011419491,
-0.02102874,
0.0019990916,
0.021695672,
-0.030515494,
-0.0077649816,
0.0049611498,
-0.026432242,
-0.018469904,
-0.015611628,
0.0322849,
-0.0021743309,
-0.0043928972,
-0.019245721,
0.025356987,
0.012120449,
-0.008091642,
0.013393062,
0.004062834,
-0.0053966963,
-0.006315428,
-0.009718137,
-0.17269428,
-0.003383994,
0.025833366,
-0.0043486618,
0.03615038,
-0.013760555,
-0.006284803,
0.025166435,
0.007894285,
-0.0074995705,
0.035115957,
0.0066080606,
-0.0504962,
-0.019994317,
0.0074519324,
-0.01629217,
-0.016891047,
0.019327387,
0.017489923,
0.02621447,
0.01051437,
-0.011514767,
0.015897457,
-0.022403436,
0.005471556,
0.0036783284,
-0.0076424843,
-0.030270498,
-0.005202742,
-0.011303799,
-0.026255302,
0.017312983,
0.015570796,
-0.0029059134,
-0.0017302774,
-0.0015712008,
0.0037191608,
-0.022988701,
0.0010871654,
0.046031848,
0.028092764,
0.011746151,
0.010003964,
0.00031687727,
-0.036449816,
0.04088695,
0.000025015228,
-0.008214139,
0.022730095,
-0.005389891,
0.0038654774,
-0.022185663,
-0.0034503469,
0.009160092,
0.0208518,
0.0052980175,
0.0153258005,
0.005845854,
-0.008928708,
0.008302609,
-0.01106561,
-0.016618831,
0.0026881401,
-0.003739577,
-0.006461744,
-0.037756458,
0.002822547,
-0.015829401,
0.005971754,
-0.0017489924,
-0.060867656,
-0.002740882,
0.015094416,
-0.014944698,
0.028092764,
0.013835414,
-0.026595572,
0.008336637,
0.026010307,
0.004726363,
-0.00406964,
0.002058639,
-0.015257747,
-0.0077105383,
-0.018320184,
0.01173254,
0.009411893,
0.01629217,
-0.0062575815,
-0.0021351997,
0.027602775,
-0.0144547075,
-0.013753749,
-0.014481929,
0.00864288,
0.03223046,
0.0006235464,
0.0048284438,
-0.0068054176,
-0.012120449,
0.050087877,
-0.008955929,
-0.017027155,
-0.0029586554,
0.008547605,
-0.0008098447,
-0.032067128,
0.004818236,
0.03800145,
0.0139306905,
-0.006870069,
0.013937496,
0.005485167,
0.030733267,
-0.003033515,
0.01220892,
0.0051380903,
-0.015448298,
-0.0021862404,
-0.03860033,
0.039634753,
0.004464354,
0.008915097,
0.008152891,
-0.0020892632,
0.0040662372,
-0.12870406,
-0.0296444,
0.03223046,
0.001401916,
-0.025261711,
0.017394647,
-0.0073158243,
-0.0056042615,
-0.026473075,
0.022280937,
-0.020797357,
-0.0051857284,
-0.008595243,
-0.009915493,
0.02166845,
0.01578857,
-0.0050564255,
-0.01597912,
0.0032121572,
0.040941395,
-0.0020144037,
-0.020484308,
-0.009650082,
-0.0034826726,
0.0013423687,
0.014345821,
-0.026432242,
0.021055963,
0.009643277,
0.031822134,
-0.013787776,
-0.008472745,
0.024254508,
-0.008336637,
-0.0042601917,
-0.00043023,
-0.027629996,
-0.015271357,
0.02817443,
-0.019585993,
-0.0005886686,
0.0047535845,
0.006179319,
-0.008057615,
-0.0056723156,
-0.02915441,
-0.029399404,
-0.01418249,
0.030107168,
-0.012617244,
-0.013733333,
-0.03990697,
-0.0005308226,
-0.004699141,
0.022879815,
-0.02735778,
0.025261711,
0.020620415,
-0.013474727,
-0.007792203,
0.006771391,
-0.0083502475,
-0.019463494,
0.017911859,
0.029263297,
-0.013386257,
0.0009025685,
-0.037402578,
0.012379055,
-0.017612422,
0.002922927,
-0.016006343,
-0.019803766,
-0.011433102,
0.014155269,
-0.000023048036,
-0.009187314,
-0.015448298,
-0.0007515733,
-0.009867855,
-0.013855831,
-0.023873406,
0.015407466,
-0.020402642,
0.038736437,
0.01131741,
0.004314635,
0.0022474893,
0.0061078626,
-0.018905452,
-0.0069517344,
0.020075982,
-0.024499504,
0.009874661,
0.013182094,
-0.00060355547,
-0.00036855592,
-0.014863033,
0.027248893,
0.024880607,
-0.0062575815,
-0.017394647,
-0.0662031,
0.00014333912,
0.0027493888,
-0.0033907995,
-0.005995573,
-0.008819821,
0.013631252,
-0.0061452924,
0.018306574,
-0.016237726,
-0.026690848,
-0.004198943,
-0.032312125,
0.0025996696,
-0.031087149,
-0.025261711,
0.020974297,
-0.0001528029,
0.01838824,
0.02247149,
0.013787776,
-0.020144036,
0.0065740338,
0.008418302,
0.019272944,
0.012154476,
-0.020565972,
0.025683647,
-0.0012419887,
-0.013910274,
-0.0001205835,
-0.014849422,
-0.022907035,
0.002711959,
-0.011460324,
-0.0032189626,
0.029698843,
0.020565972,
0.014903865,
0.022798149,
-0.011045193,
-0.025043938,
0.02621447,
0.015666071,
0.0020756524,
0.004266997,
-0.019980706,
0.010800198,
0.008078031,
-0.012174892,
0.040941395,
0.024213677,
0.016251337,
-0.029426627,
-0.028528312,
0.008241361,
-0.004338454,
-0.020307366,
-0.023165641,
-0.027820548,
0.017884638,
0.00016067165,
-0.005144896,
-0.0009570119,
0.02036181,
-0.016891047,
-0.028800528,
0.0068564583,
0.012338222,
-0.0073770727,
-0.020348199,
0.024717277,
0.00020352453,
-0.0031815327,
-0.0015431285,
0.0015329204,
-0.026309745,
0.009085232,
-0.009554806,
0.019585993,
0.019204888,
-0.023424247,
-0.023192864,
0.003086257,
0.012249752,
0.010255764,
0.004420119,
0.030651601,
0.0074179056,
0.0033414601,
0.007669706,
0.009126065,
-0.007833036,
0.009105649,
0.0187149,
0.01987182,
0.005481764,
0.0061078626,
-0.0081733065,
0.051530622,
0.00813928,
-0.0012743145,
0.017707696,
-0.009200925,
-0.018660456,
0.0016511645,
-0.033754874,
-0.021246515,
-0.023805352,
-0.0023121408,
0.0081324745,
0.00074731995,
0.010752561,
0.008363859,
-0.0472296,
0.024295341,
-0.02183178,
-0.0018442682,
-0.00155759,
0.03141381,
0.018102411,
0.0093098115,
-0.0014529567,
-0.011929898,
-0.006346052,
0.0051482986,
0.017340204,
-0.015829401,
-0.002443145,
0.011011166,
0.012351833,
-0.009126065,
-0.02572448,
-0.031168813,
-0.0023444665,
-0.030270498,
0.016850214,
-0.0069959695,
-0.006781599,
0.07730955,
0.0014138256,
-0.033972647,
0.0224851,
-0.011507962,
0.04053307,
-0.010487149,
0.045514636,
-0.024839776,
-0.017136041,
0.033509877,
-0.004450743,
0.024826163,
-0.03402709,
-0.012726131,
0.030107168,
-0.010072018,
-0.0016001238,
0.0062269573,
-0.016156062,
0.012113644,
-0.026268912,
-0.010534787,
-0.0027391806,
-0.008595243,
-0.01287585,
0.016537165,
-0.0068122232,
0.0016928477,
-0.008037198,
0.0153258005,
0.005706343,
-0.02753472,
-0.0064583416,
-0.0019735713,
-0.0063188304,
-0.019232111,
-0.0032172613,
0.015298579,
-0.0020994714,
0.0077581764,
0.03111437,
-0.037266467,
-0.03367321,
-0.017898249,
-0.04053307,
-0.027453056,
-0.0084795505,
-0.0077717872
] |
The prediction of novel pre-microRNA (miRNA) from genomic sequence has received considerable attention recently. However, the majority of studies have focused on the human genome. Previous studies have demonstrated that sensitivity (correctly detecting true miRNA) is sustained when human-trained methods are applied to other species, however they have failed to report the dramatic drop in specificity (the ability to correctly reject non-miRNA sequences) in non-human genomes. Considering the ratio of true miRNA sequences to pseudo-miRNA sequences is on the order of 1:1000, such low specificity prevents the application of most existing tools to non-human genomes,
|
[
-0.032219224,
-0.031847056,
-0.009496962,
-0.024310628,
0.0012053964,
0.020814896,
-0.00801493,
-0.004745158,
-0.043995723,
-0.009217835,
0.017850833,
0.0077557415,
0.010168196,
-0.02093452,
0.0028411136,
0.01151731,
0.03498391,
-0.007795617,
0.018980632,
-0.022117488,
-0.020216765,
0.019990806,
-0.025759429,
-0.03384082,
-0.010075154,
0.009915653,
0.020748436,
-0.03679159,
-0.025360677,
-0.021426316,
0.0011198308,
0.010228009,
-0.017279288,
-0.016229238,
-0.011696748,
0.00082533516,
0.009623233,
-0.007609532,
0.005200401,
-0.029374788,
0.021625692,
0.020376267,
-0.010753033,
-0.01685395,
0.000993559,
0.009197897,
0.020907937,
-0.0035655145,
-0.03461174,
0.010493844,
0.0036186813,
-0.0068651936,
-0.017279288,
0.0051173274,
-0.035329495,
0.017106494,
-0.0009021782,
0.0024274075,
0.012753443,
-0.011105265,
-0.003387737,
-0.00087393314,
-0.027593693,
0.016083028,
-0.013251884,
0.012766735,
-0.0072639463,
-0.009922299,
0.009038396,
-0.010593532,
0.015896944,
0.007788971,
-0.0021050824,
-0.006117532,
0.029507706,
-0.01759829,
-0.01843567,
-0.008194369,
-0.005034254,
0.0020369622,
0.01858188,
-0.004515875,
-0.0065594832,
0.007496552,
0.0031933452,
0.010832784,
0.001789403,
-0.0063102627,
0.012321461,
-0.009556775,
0.033388898,
0.018834423,
0.022383323,
0.02417771,
-0.019392677,
-0.016056444,
-0.012414503,
0.025719553,
-0.0067056925,
-0.02327387,
-0.03280406,
0.0014122494,
-0.02069527,
-0.01012832,
-0.0012884699,
0.013092383,
0.016335571,
-0.022622574,
0.009357398,
-0.019605344,
-0.010327697,
0.023074495,
-0.01957876,
-0.02493534,
0.0311293,
-0.0004901336,
0.021878235,
0.0019455813,
-0.003818058,
-0.010347635,
0.030810298,
0.0013092383,
0.0054496215,
-0.03974236,
0.023566289,
0.016455198,
-0.011098619,
0.0024689443,
-0.0048847217,
0.0063900133,
0.010586887,
0.006233835,
0.022649158,
0.032697726,
-0.020336391,
0.009071626,
-0.025081549,
-0.005958031,
-0.013052507,
-0.03716376,
-0.011836312,
0.02969379,
-0.013570886,
0.00073727727,
0.019352801,
0.0035289621,
0.009815964,
-0.004868107,
0.017957166,
0.015126022,
0.010101737,
-0.03368132,
0.0034525346,
0.00827412,
0.006021167,
-0.006130824,
-0.008985229,
0.0017212828,
-0.009104855,
-0.006107563,
0.011018869,
-0.003337893,
0.0153785655,
0.010434031,
-0.0010002048,
0.028497532,
0.0013549287,
-0.005758655,
0.001736236,
-0.02124023,
0.0033179554,
0.020894645,
-0.033442065,
0.02372579,
-0.006958236,
-0.0015817194,
0.010247947,
-0.000012071618,
-0.017717915,
-0.010460614,
-0.012653755,
0.021226939,
0.011995813,
0.0039609442,
-0.02712848,
0.017199537,
0.018528713,
-0.003582129,
0.005084098,
-0.018488837,
-0.00027102727,
-0.020801604,
0.034026902,
0.028417781,
-0.6418325,
-0.051518857,
0.0011156771,
-0.004874753,
0.013810138,
0.019857889,
0.0035455767,
-0.009629879,
-0.013291759,
0.03559533,
-0.021931402,
-0.017053327,
0.009590005,
-0.020429434,
-0.020043973,
-0.036233336,
0.014075973,
-0.027022146,
0.023008035,
0.0051405877,
-0.013717095,
0.017133078,
0.013165488,
0.019073674,
-0.013431323,
-0.018635046,
-0.012261648,
-0.032033138,
0.009051688,
0.02411125,
-0.021585817,
0.042347547,
-0.01722612,
0.01466081,
0.046521157,
-0.025653096,
0.007303822,
0.041363955,
0.012261648,
0.015737442,
-0.018409086,
0.0022762138,
0.0112780575,
0.012494254,
-0.023513122,
0.02077502,
-0.008313996,
-0.012035688,
0.009802672,
0.008958646,
-0.0029673853,
0.021718735,
-0.005423038,
-0.0043829577,
-0.011749915,
0.013969639,
0.03572825,
-0.021599108,
0.024151126,
-0.0031783918,
-0.021811778,
0.014926646,
0.017584998,
-0.0070778616,
-0.024868881,
0.017970458,
-0.010626761,
-0.0019040445,
0.011098619,
-0.005187109,
0.03211289,
0.02637085,
0.007822201,
-0.0063501378,
-0.012048979,
0.033309147,
0.010759679,
0.01390318,
0.0028128684,
-0.00441951,
0.011218245,
-0.0041270913,
-0.026769603,
0.015006396,
0.007908597,
-0.009304231,
-0.017159661,
0.021971278,
0.009756152,
-0.010055216,
-0.010400802,
-0.0012884699,
0.0040606325,
-0.023393497,
-0.017638164,
-0.007682637,
-0.017704623,
0.013391447,
0.020456018,
-0.028922869,
-0.020269932,
0.0063135857,
0.029029202,
0.004542459,
0.008114619,
-0.011284703,
-0.015710859,
-0.0011297995,
0.026131598,
-0.031288803,
0.0094305035,
0.0054031,
-0.008932062,
0.0018093407,
-0.016946994,
-0.027101897,
0.005363225,
0.016588116,
-0.011085327,
-0.023925167,
-0.007503198,
-0.009550129,
-0.01046726,
0.0017162984,
-0.010194779,
-0.009570067,
0.00023219042,
-0.008952,
0.032086305,
-0.017013451,
-0.0077557415,
-0.02229028,
0.011437559,
-0.0075231357,
0.0059912605,
0.00506416,
0.015670985,
0.039715778,
-0.010566949,
-0.0035023785,
-0.019140134,
-0.017252704,
-0.007994994,
0.0045889798,
-0.00827412,
-0.015950112,
-0.011311287,
-0.010779616,
0.0150462715,
-0.021466192,
0.019312926,
-0.011091973,
0.008526663,
0.0037848284,
-0.015325398,
-0.0035256392,
-0.016508365,
-0.03211289,
-0.0012527483,
-0.027022146,
0.0066990466,
0.035675082,
-0.010640053,
0.023366913,
-0.0016332249,
-0.019618636,
0.008220953,
0.0111916615,
-0.0134512605,
-0.049312428,
0.027886111,
-0.016016569,
-0.0006039443,
0.0059879376,
-0.008858957,
0.012939528,
-0.028364614,
0.0080880355,
-0.02833803,
-0.02153265,
-0.011577122,
-0.022941576,
-0.014301933,
-0.0054296837,
0.027646858,
0.032697726,
0.04208171,
-0.0050409,
0.01707991,
0.024310628,
-0.006473087,
-0.01707991,
-0.014115849,
0.030544464,
0.0025786012,
-0.02266245,
0.024603046,
0.0039177462,
-0.012148668,
0.024656214,
0.025334094,
-0.0007501537,
-0.01812996,
-0.037987847,
-0.004037372,
-0.018316044,
-0.00058691425,
-0.021519357,
-0.005901541,
0.0008440267,
-0.015192481,
0.0012469331,
-0.0023044588,
-0.031235633,
0.01412914,
0.010892597,
-0.006905069,
-0.00796841,
-0.017717915,
-0.001739559,
0.008659581,
0.015365274,
0.017877417,
0.006625942,
0.01012832,
0.030278627,
0.004323145,
-0.0028294832,
0.012088855,
-0.0166147,
-0.0042965612,
0.016375447,
0.011796436,
0.0009486993,
0.014235474,
0.014036098,
0.0078421375,
-0.015232356,
0.016189363,
0.008965292,
-0.03346865,
-0.008546601,
-0.008061452,
-0.008858957,
0.015458316,
-0.012713567,
0.0074168015,
0.018262878,
-0.00425004,
0.014993104,
-0.0127800265,
-0.006071011,
-0.020801604,
0.011171724,
0.003535608,
-0.038067598,
0.0017312516,
-0.0034957326,
0.05545322,
0.025799304,
0.011105265,
0.00441951,
0.015617817,
-0.035409246,
0.014607644,
0.0023260578,
0.033362314,
-0.006512962,
-0.014674102,
0.011882832,
-0.0061873137,
-0.019711679,
-0.00078587525,
-0.033388898,
-0.008294058,
0.005133942,
0.012660401,
0.007795617,
0.023659332,
0.012002459,
-0.031182468,
-0.027248107,
0.033202816,
0.016016569,
-0.017505247,
-0.017398912,
-0.025879055,
-0.014860187,
-0.006742245,
-0.00007782948,
-0.0058217905,
-0.0014745545,
-0.0026782895,
-0.004878076,
-0.0049279197,
-0.0012552405,
0.031820472,
-0.031847056,
0.004416187,
0.0010616792,
0.023180827,
-0.027407607,
-0.019166717,
-0.016867243,
0.017997041,
-0.0012220112,
-0.0075895945,
0.002435715,
-0.0029790155,
0.005014316,
-0.012686985,
-0.00568555,
-0.00022533686,
0.0042201336,
-0.014434851,
0.017624872,
-0.014953229,
0.00762947,
0.01798375,
0.016282406,
-0.008520017,
-0.041443706,
-0.0015335367,
0.009855839,
0.03929044,
0.020721853,
-0.010473906,
0.012574004,
0.011304641,
0.022689033,
-0.028896285,
-0.022981452,
0.03227239,
-0.020442726,
-0.025121424,
0.0023958397,
-0.011769853,
-0.007503198,
0.019166717,
0.014753853,
0.010028632,
-0.027248107,
-0.029826708,
0.007662699,
0.004898013,
0.018555297,
0.025294218,
0.023925167,
0.011643581,
-0.005755332,
0.019618636,
0.01700016,
-0.003974236,
0.0021333273,
0.005758655,
0.0028195144,
-0.010447322,
0.015285523,
0.011424267,
0.007994994,
0.018329335,
-0.0069848197,
0.00627371,
-0.007901951,
0.01729258,
0.018342627,
0.011656873,
0.00010098622,
-0.006778797,
-0.00007777756,
-0.006991465,
0.011803082,
-0.00568555,
-0.018927464,
0.00835387,
-0.0031916837,
-0.015710859,
-0.010985639,
0.015750734,
0.022861825,
-0.01918001,
-0.002078499,
-0.02251624,
-0.022582699,
-0.014448143,
-0.02727469,
0.0013532672,
0.014488017,
-0.013889888,
-0.013717095,
-0.011464142,
-0.013251884,
-0.034266155,
-0.025759429,
0.010168196,
-0.01348449,
-0.023925167,
-0.010766325,
0.013152196,
0.021638984,
0.009151376,
-0.018648338,
0.01466081,
0.015232356,
-0.007975056,
-0.02303462,
0.019512303,
-0.034345906,
0.032166056,
-0.0070579243,
-0.019366093,
-0.03120905,
-0.032139473,
-0.014315224,
-0.012441087,
0.009988757,
0.014860187,
0.017239412,
0.009337461,
0.008652935,
-0.008367162,
0.046893325,
-0.0034359198,
-0.018821131,
-0.007463323,
-0.03392057,
-0.007994994,
-0.029746957,
-0.013889888,
-0.014009514,
-0.0068519018,
-0.009576713,
-0.017345745,
-0.023978334,
0.010394156,
-0.0130392155,
0.01828946,
0.021519357,
0.037722014,
-0.0010234654,
0.0145411845,
0.031900223,
0.017518539,
-0.022090904,
-0.032963563,
-0.0068120267,
0.010885951,
0.012387919,
0.0049445345,
0.008805791,
-0.0059380936,
-0.008878895,
-0.037349842,
0.0029823384,
-0.013404739,
0.047956668,
0.021718735,
-0.029135536,
-0.022502948,
-0.014089265,
0.011497372,
-0.0014446481,
-0.008034868,
-0.01012832,
-0.015657693,
-0.0010068507,
0.00036282348,
0.0028477595,
0.016960286,
-0.029879875,
0.00056780735,
0.028869702,
-0.005536018,
0.01004857,
-0.004366343,
0.014913354,
-0.027155064,
-0.02727469,
-0.014169015,
-0.012421149,
0.0009221158,
-0.0031169176,
0.0332294,
0.024603046,
0.033893988,
-0.021878235,
-0.015418441,
0.030703964,
0.0023858708,
-0.008858957,
0.00413706,
0.014195599,
-0.0061839907,
0.0022712294,
0.026610103,
-0.018143252,
-0.004083893,
-0.0040639555,
-0.011656873,
-0.00014589782,
-0.01896734,
-0.020442726,
-0.002892619,
-0.030119127,
-0.017850833,
0.0025088196,
-0.0064963475,
0.010314405,
-0.029560873,
-0.0356485,
0.038865104,
-0.017239412,
0.028683616,
-0.011676811,
0.023486538,
0.005781915,
0.005894895,
-0.014301933,
0.02530751,
-0.026198057,
0.0009561759,
-0.027155064,
0.0055991537,
0.018422378,
-0.005363225,
0.019432552,
0.016189363,
-0.0025686324,
0.0037216926,
0.011351163,
-0.029614039,
-0.0109391175,
0.005625737,
-0.024510004,
-0.0118562495,
-0.014860187,
-0.0016897148,
-0.01488677,
-0.014102557,
0.0142088905,
0.008553247,
0.001598334,
-0.008453559,
-0.02153265,
0.0067189843,
0.007675991,
0.030757131,
-0.0068917773,
0.020389559,
0.022542823,
-0.01630899,
-0.02093452,
-0.004864784,
0.017106494,
-0.005077452,
0.03998161,
0.008686164,
-0.00071692426,
-0.03067738,
0.041496873,
0.0077690333,
-0.016043153,
-0.0403272,
0.020057265,
0.0013341603,
0.0045989486,
-0.017412204,
-0.006606004,
-0.025440427,
0.031528052,
-0.015285523,
0.013996222,
-0.0106068235,
-0.018555297,
-0.013105675,
-0.0057785925,
0.005585862,
0.011876187,
-0.01280661,
-0.015232356,
-0.0117764985,
0.0049312427,
0.027301274,
-0.008526663,
-0.00070986303,
0.017412204,
-0.013491136,
-0.01117837,
0.03408007,
-0.009310877,
0.001767804,
-0.0005993753,
-0.0037349844,
0.040061362,
-0.020389559,
-0.021732027,
0.002354303,
-0.00086147216,
-0.009975465,
0.013477844,
-0.003115256,
-0.01880784,
-0.004130414,
-0.002683274,
0.009629879,
0.050721355,
0.0039077774,
-0.0034691491,
-0.01004857,
0.01280661,
-0.026184766,
-0.018395795,
0.015365274,
-0.014913354,
-0.018940756,
0.0064830557,
0.015445024,
0.014780437,
0.016960286,
-0.02756711,
-0.0039343606,
0.03104955,
-0.019764846,
0.0128664225,
0.020004097,
-0.024443544,
-0.037961263,
0.0005017639,
-0.010600178,
-0.019844597,
0.0044261557,
-0.051651776,
-0.031528052,
0.018528713,
0.0058284365,
0.012926236,
0.014155723,
-0.015777318,
-0.0027696702,
0.0077490956,
0.01828946,
-0.005735394,
0.00022180623,
0.0023592873,
-0.042267796,
0.0036319732,
0.012348045,
0.007988348,
0.013172134,
-0.014634226,
-0.0113578085,
0.022011153,
-0.005240276,
-0.027381023,
-0.0056656124,
0.005027608,
-0.0073702806,
0.002429069,
-0.009118147,
-0.0024406994,
-0.015843777,
0.010061862,
0.011504018,
-0.004353051,
-0.0166147,
0.0050940667,
-0.0046554385,
0.0060543963,
-0.0074766143,
-0.0023127662,
0.0077490956,
-0.016627992,
-0.035861168,
0.00052128616,
-0.010553657,
0.028683616,
0.024802422,
-0.000937069,
-0.022250405,
-0.00160498,
-0.029215287,
-0.02561322,
0.023778956,
0.028045611,
0.0045059063,
0.023101078,
0.00678212,
0.006130824,
-0.016867243,
0.015351982,
0.0031418395,
-0.027540525,
-0.003532285,
0.009895715,
0.028577283,
0.018861007,
-0.019764846,
-0.0037050778,
0.043783054,
-0.011603706,
-0.02395175,
0.029454539,
-0.0067621823,
0.02756711,
-0.01782425,
0.0070845075,
0.00281453,
0.018090084,
0.028657032,
-0.024390379,
-0.023300454,
-0.0013549287,
-0.011377746,
-0.041895624,
0.009118147,
-0.007124383,
0.009902361,
0.018329335,
-0.013012632,
-0.023260579,
0.0008099666,
0.00075638416,
0.004967795,
0.0109391175,
0.013112321,
0.018023625,
-0.008333933,
-0.0028577282,
-0.016654573,
-0.013318343,
0.022994744,
0.0076959287,
0.038067598,
0.017040035,
0.0039243917,
-0.023287162,
-0.008991875,
-0.014953229,
0.008300704,
-0.015697567,
0.0068917773,
-0.008539955,
0.024975216,
0.006459795,
-0.004309853,
0.024390379,
-0.00021111051,
0.009304231,
-0.0029756925,
0.015989987,
-0.0120290425,
-0.0026915811,
0.007609532,
0.005057514,
-0.00937069,
-0.032086305,
-0.004848169,
0.011118556,
-0.027912695,
0.016534949,
0.18980633,
-0.015538067,
-0.000669157,
0.01670774,
0.0077424496,
-0.011437559,
0.01782425,
0.005752009,
-0.0044328016,
-0.01692041,
0.033973735,
-0.0053432873,
-0.032830644,
-0.0001011939,
0.009304231,
-0.016800784,
-0.018395795,
-0.029215287,
0.0014454788,
-0.00066458795,
0.00835387,
0.004751804,
-0.006087626,
-0.009217835,
0.027912695,
0.020602226,
-0.015644401,
0.010314405,
-0.011916062,
0.009603296,
-0.027301274,
0.0013673897,
0.0009844209,
0.017651455,
-0.0048880447,
0.014301933,
0.011118556,
0.021040855,
0.00029698774,
0.0049378886,
-0.014993104,
0.023739083,
0.015272232,
-0.011975875,
0.0203231,
0.025254343,
-0.008672873,
-0.0017345746,
-0.0062238663,
-0.012959465,
-0.012686985,
0.03572825,
-0.0050043473,
0.01995093,
-0.0074035097,
0.003068735,
-0.0019356124,
-0.0029408017,
0.0066458797,
0.022489656,
-0.008380454,
-0.019206593,
0.0034458886,
0.039955027,
-0.040832285,
0.031421717,
-0.015471607,
0.011809728,
0.029481122,
-0.0026384143,
-0.0056988415,
-0.02235674,
-0.02093452,
-0.012813256,
-0.01828946,
-0.029135536,
0.059653416,
0.02772661,
0.028391197,
0.008426975,
0.0022197238,
-0.021944694,
-0.03777518,
-0.02577272,
-0.013690512,
-0.03665867,
0.029427955,
-0.0036851403,
-0.009423858,
0.00031318708,
0.012009105,
-0.008878895,
-0.027022146,
-0.011231537,
0.011816374,
0.011457496,
-0.00425004,
0.0063567837,
-0.016322281,
-0.038492933,
-0.035488997,
0.08208991,
-0.023765665,
0.0180635,
0.0032398663,
0.020349683,
-0.016083028,
0.0111916615,
0.002698227,
0.02130669,
0.025280926,
-0.038200516,
0.005941416,
-0.019512303,
0.007882013,
0.038652435,
0.015179189,
-0.03929044,
0.03240531,
0.002015363,
0.0065561603,
0.016574824,
0.012846486,
0.052475866,
-0.009942235,
-0.010134966,
-0.010553657,
0.0076892828,
0.00032253284,
-0.0113711,
-0.0020336392,
-0.014474725,
0.012480962,
0.0090915635,
0.02056235,
-0.023260579,
0.025360677,
-0.013557594,
-0.0071443208,
0.000032398664,
0.009656463,
-0.02001739,
0.0145411845,
0.022104196,
0.014421559,
0.028683616,
0.037110593,
0.03511683,
-0.001796049,
0.0031235635,
-0.0015127683,
-0.014594352,
0.004675376,
0.007117737,
0.020735145,
-0.0032548194,
-0.014421559,
-0.012760089,
-0.016149487,
-0.010360926,
-0.03461174,
0.022649158,
0.01291959,
-0.011098619,
-0.012607234,
-0.0032415278,
-0.16705082,
0.0100153405,
0.021160481,
-0.042028543,
0.02546701,
0.0075297817,
0.001447971,
-0.012753443,
0.011337871,
-0.01759829,
0.029055785,
0.004156998,
-0.0066026812,
-0.035010494,
0.0009810979,
0.0056622894,
-0.021878235,
0.026184766,
0.029667206,
-0.00040166033,
0.011995813,
-0.023047911,
0.007503198,
-0.017199537,
0.0058217905,
0.014620936,
-0.018528713,
0.013324989,
0.006606004,
-0.036818173,
-0.007988348,
0.0039509754,
0.022316864,
-0.004705283,
0.02138644,
0.009669755,
0.009842548,
0.004246717,
-0.021173773,
-0.0048249085,
0.03506366,
0.021266814,
0.008493434,
-0.020309808,
0.010972347,
-0.00094039197,
0.011729977,
-0.010188133,
0.012288231,
-0.018674921,
0.015245648,
-0.0008772561,
0.035382662,
-0.010566949,
0.010274529,
-0.002018686,
0.0089254165,
0.026184766,
-0.00028141146,
-0.006449826,
-0.020150308,
-0.023685915,
0.02666327,
0.0040872158,
-0.005728748,
0.0016714387,
0.0042400714,
0.016202655,
-0.008347224,
0.0042766235,
-0.022077613,
-0.005555955,
0.0029358172,
-0.0070446325,
0.021479484,
0.025081549,
-0.025148008,
0.015086147,
-0.0060377815,
-0.0047916793,
-0.0214529,
0.006905069,
-0.017850833,
0.005622414,
0.014262058,
-0.009975465,
0.023685915,
0.0017295901,
-0.0058417283,
0.0123679815,
0.027301274,
-0.0074300934,
0.0057653007,
-0.0049611493,
0.020083848,
0.011025514,
0.017279288,
-0.006237158,
-0.005569247,
-0.020429434,
-0.010347635,
0.0063169086,
-0.0035023785,
0.0030571045,
0.024975216,
0.00046022717,
-0.009264356,
-0.0039210687,
0.045431234,
-0.012906298,
-0.0065428684,
-0.0026184765,
0.014846895,
0.02719494,
-0.0026500444,
0.03543583,
0.01046726,
-0.004751804,
-0.019857889,
-0.02493534,
0.057739403,
-0.009204543,
0.002291167,
0.02425746,
-0.0049478575,
-0.023925167,
-0.13621394,
-0.0132851135,
0.013165488,
0.014474725,
-0.017930584,
0.027168356,
0.0011655211,
0.01979143,
-0.037908096,
0.021319982,
-0.00018120406,
-0.019259758,
-0.0047617727,
-0.017704623,
-0.01046726,
-0.0032863875,
-0.013331635,
-0.019552179,
0.0056157685,
0.032245807,
0.018980632,
-0.0027497327,
-0.0059347707,
-0.00796841,
0.013424677,
-0.0015825501,
-0.02222382,
0.011238182,
0.01398293,
0.008021576,
0.020243349,
-0.019525595,
0.0047950023,
-0.009563421,
-0.035409246,
0.012135376,
-0.014607644,
-0.009271002,
0.010327697,
0.0027779776,
-0.00006837987,
0.015086147,
-0.00031692538,
0.015072855,
0.01356424,
-0.010759679,
0.0033511848,
0.016043153,
-0.0021333273,
-0.036605503,
-0.018036917,
-0.030491296,
-0.04200196,
-0.011317933,
0.016189363,
-0.012992695,
0.008586477,
-0.0004064371,
-0.01525894,
-0.011085327,
-0.008034868,
0.007775679,
-0.0034492116,
0.010553657,
0.008539955,
-0.013045861,
-0.004572365,
-0.02441696,
0.01911355,
-0.020389559,
0.0014080957,
0.017133078,
0.0016440245,
-0.002510481,
-0.010553657,
0.007722512,
-0.029241871,
-0.030597629,
0.014102557,
-0.008480143,
0.0026068462,
-0.019459136,
0.019671803,
-0.019126842,
0.018688213,
-0.009722922,
0.01640203,
-0.005918156,
-0.010453968,
-0.00018400779,
-0.011072036,
0.039343607,
-0.017771082,
-0.007961764,
-0.0013715434,
0.020416142,
-0.0010791247,
-0.006393336,
0.025746137,
0.0022978128,
-0.0019954254,
-0.009350752,
-0.03801443,
0.008765915,
-0.0053399643,
-0.024735963,
0.018834423,
-0.032431893,
-0.003224913,
-0.002846098,
-0.00521037,
0.0003676002,
-0.029507706,
-0.013404739,
-0.017478663,
-0.012474316,
-0.032298975,
0.0072373627,
0.024124542,
-0.008506726,
0.008407038,
0.017026743,
-0.008028222,
0.007310468,
-0.0046255323,
0.011218245,
-0.013165488,
-0.013391447,
-0.030943215,
0.026556935,
0.003990851,
-0.017704623,
0.012454378,
-0.007230717,
-0.018861007,
0.006615973,
-0.011557185,
-0.016694449,
0.03120905,
0.01979143,
0.014501309,
0.031235633,
-0.014328516,
-0.039317023,
-0.014009514,
0.024044793,
0.009809318,
0.015923528,
-0.025972098,
-0.012480962,
0.005456267,
-0.014222182,
0.034957327,
0.013637345,
-0.0042367484,
-0.038041014,
-0.037509345,
-0.012574004,
0.010879305,
-0.0080880355,
0.0034259509,
-0.0056656124,
0.030039376,
0.016867243,
-0.015139313,
-0.00608098,
-0.023101078,
0.0075364276,
-0.029082369,
0.017066618,
0.005373194,
-0.0056124455,
-0.038944855,
0.00521037,
0.003136855,
-0.011929354,
0.02704873,
-0.013477844,
-0.01050049,
0.015112731,
0.0012710245,
0.02509484,
0.020283224,
0.017345745,
-0.0032996791,
0.012082209,
0.029640622,
0.0051505566,
0.00419355,
0.0042168107,
-0.013477844,
0.001667285,
0.0021931403,
0.022037737,
0.007323759,
0.022875117,
-0.023752375,
0.02478913,
-0.016441906,
0.019405968,
0.0017727884,
0.0137038035,
0.008426975,
-0.009656463,
0.021732027,
-0.028019028,
-0.00869281,
0.020269932,
-0.037349842,
-0.019512303,
0.019166717,
-0.009968819,
0.010301113,
0.01012832,
-0.00019532656,
-0.0027248107,
-0.0087592695,
0.048674423,
-0.0033295858,
-0.019246466,
-0.022941576,
0.024775838,
0.020043973,
0.019618636,
0.014793728,
-0.01050049,
0.013092383,
0.016282406,
0.023818832,
-0.043570388,
0.03232556,
-0.010041924,
0.020961104,
-0.013398093,
0.000040654093,
-0.012181898,
-0.009676401,
0.020083848,
-0.009310877,
0.0018957371,
-0.008094681,
0.063056104,
0.016747616,
0.007682637,
-0.0016838998,
-0.029640622,
0.031926807,
0.024124542,
0.021811778,
-0.008480143,
-0.013889888,
0.012480962,
-0.01466081,
0.019698387,
-0.027513942,
-0.01224171,
0.019405968,
-0.031474885,
0.011091973,
-0.024682797,
0.0006110056,
0.035887748,
-0.002156588,
0.029454539,
-0.007915243,
-0.025573345,
-0.0022263697,
0.027407607,
0.0013698819,
0.0024938663,
-0.010560303,
0.025041675,
0.007908597,
-0.022117488,
0.0054728817,
0.016601408,
0.004748481,
-0.00047227283,
-0.02229028,
0.022875117,
-0.0020801604,
0.019140134,
-0.0056722583,
-0.019592052,
-0.013437969,
0.011058744,
-0.010713158,
-0.0142088905,
-0.00850008,
0.018914172
] |
Leishmania mexicana (Lm) causes localized (LCL) and diffuse (DCL) cutaneous leishmaniasis. DCL patients have a poor cellular immune response leading to chronicity. It has been proposed that CD8 T lymphocytes (CD8) play a crucial role in infection clearance, although the role of CD8 cytotoxicity in disease control has not been elucidated. Lesions of DCL patients have been shown to harbor low numbers of CD8, as compared to patients with LCL, and leishmanicidal treatment restores CD8 numbers. The marked response of CD8 towards Le
|
[
-0.016559178,
0.018342473,
0.030999852,
-0.03330607,
-0.023745995,
0.028210938,
-0.022123598,
0.009640525,
-0.012556817,
-0.0041096257,
0.0039319666,
0.020943671,
0.014856331,
0.04167281,
-0.013119964,
0.029685846,
0.034459177,
0.000104280494,
-0.0073611243,
0.0011162361,
-0.046767943,
0.0046057305,
0.019160377,
-0.0218018,
0.009975731,
0.012530001,
0.005007978,
-0.02370577,
-0.013642885,
0.0016584317,
-0.002944785,
-0.006570038,
-0.020755956,
0.006516405,
-0.010230487,
0.00014864292,
0.04341588,
-0.01379708,
0.012147866,
-0.0007064467,
0.0077164425,
0.010518765,
-0.0026766201,
-0.002120178,
0.013783672,
0.01592899,
0.005671686,
-0.018610638,
-0.014668616,
0.032877006,
0.025663372,
0.006831499,
-0.002346442,
0.003958783,
-0.010411499,
-0.009613709,
0.013656293,
-0.004917472,
0.022659928,
-0.032689292,
-0.011671874,
0.003958783,
-0.0049208244,
0.010847267,
0.0056515737,
0.020742549,
0.00558118,
0.03665813,
0.029685846,
0.008789102,
0.046982475,
0.032501575,
0.014038428,
0.004029176,
0.021091163,
-0.013059626,
-0.015942398,
-0.0066203186,
0.011008166,
0.00039826665,
0.02300854,
-0.023866668,
-0.011651761,
0.01875813,
0.015580376,
-0.008105282,
0.0056616296,
-0.007233746,
-0.025113635,
-0.012905432,
-0.0035531837,
0.012516593,
0.012315469,
0.0076561053,
-0.033949666,
-0.004394551,
0.0012888671,
0.021466594,
-0.002844223,
-0.024590714,
-0.008628203,
0.008782398,
-0.018650863,
-0.023772812,
-0.021962699,
-0.002891152,
-0.00081706466,
-0.009975731,
0.029739479,
-0.010398091,
-0.018181574,
0.027701424,
0.005604645,
-0.065378584,
0.020688916,
-0.014521125,
0.0033202155,
0.002056489,
-0.014628391,
-0.0027889141,
0.015446293,
0.016666444,
-0.010699776,
-0.024349365,
0.022646518,
0.015794907,
-0.011417117,
-0.011772435,
-0.02118502,
0.0013869149,
-0.0013542323,
0.024014158,
-0.0005367486,
0.0029330526,
-0.0028039983,
0.00069890457,
-0.018704496,
0.002004532,
-0.012275244,
-0.011537791,
-0.00053130154,
0.032957457,
-0.0055241953,
0.0003848584,
0.029819928,
0.024791837,
0.029283598,
0.016063072,
-0.013435057,
0.008829326,
0.002617959,
-0.017739102,
0.018302249,
-0.013240637,
-0.002230796,
0.01169869,
0.011088615,
0.026923748,
-0.0067577534,
-0.022297904,
-0.031643447,
-0.0037576593,
0.020367118,
0.0026330433,
0.04931551,
0.033654682,
0.008065057,
-0.0014296536,
0.005101836,
0.022807417,
-0.0018469852,
0.03665813,
-0.01158472,
0.04786742,
-0.027325995,
0.019656481,
0.009513147,
0.0048135584,
-0.024443222,
-0.007341012,
-0.010471836,
0.035505023,
0.014467492,
-0.0059398506,
-0.0193615,
0.0065867985,
0.0021855433,
-0.0052292137,
0.00013135886,
-0.022995133,
0.010947828,
0.01744412,
0.011933334,
-0.037918504,
-0.62943643,
-0.031804346,
0.0047029406,
0.011383597,
-0.0036269291,
0.013401536,
0.014092061,
0.006124214,
-0.033225622,
0.004736461,
0.0031676968,
-0.0064359554,
0.0068717236,
-0.042960003,
-0.003670506,
-0.031723898,
-0.010760114,
0.004461592,
-0.012570226,
-0.009117603,
0.00039219105,
-0.02292809,
-0.008929889,
0.026253335,
-0.011014869,
0.0041867234,
0.027674608,
-0.019857604,
0.020139178,
0.031992063,
-0.025086818,
0.004438128,
-0.023987344,
-0.007743259,
0.048511013,
0.0113903005,
0.0019441949,
0.010156742,
0.021533635,
0.05030772,
-0.021386145,
0.0012427763,
0.017497754,
-0.014387042,
-0.024805246,
0.019401724,
0.01516472,
0.01851678,
-0.008849439,
-0.005018034,
0.013455169,
-0.01988442,
-0.030624421,
-0.0074214614,
0.014440675,
-0.0027738297,
0.001614017,
-0.023692362,
-0.0017732398,
-0.0066571916,
-0.016063072,
-0.002829139,
-0.012670787,
-0.020058729,
-0.023960527,
-0.004518577,
-0.013528915,
-0.0036436894,
0.01646532,
0.0058627534,
0.0019140263,
0.022110188,
-0.0049442886,
-0.0015126171,
-0.0035766482,
0.021962699,
-0.00971427,
-0.017645245,
-0.016022848,
-0.0010156742,
-0.0016550797,
-0.017832961,
-0.01002266,
0.01158472,
0.019455357,
-0.023102399,
0.0067745135,
-0.009539964,
-0.016532362,
0.00044372896,
0.021627491,
0.0145613495,
-0.027151687,
-0.039205696,
-0.016076481,
0.03207251,
-0.031723898,
-0.008105282,
-0.020393934,
-0.004769982,
-0.015258578,
-0.0116048325,
0.018691087,
-0.0006008568,
0.042665023,
0.022056555,
-0.037167642,
0.010445019,
0.03955431,
-0.05030772,
-0.008132098,
0.0037073786,
0.011826068,
-0.017189365,
0.021506818,
-0.013086443,
0.00052124535,
0.0015670882,
0.019120151,
-0.032689292,
0.0017137408,
0.0031559647,
0.0218018,
-0.03641678,
-0.0018738017,
-0.0059264423,
0.00013492042,
-0.0206621,
0.020916855,
-0.024577305,
-0.012174683,
-0.016398279,
0.035692737,
-0.026427642,
0.015057454,
0.004733109,
0.038803447,
-0.006298521,
0.0015277014,
-0.02347783,
-0.014159102,
-0.017350264,
0.0072605624,
-0.002612931,
0.007086255,
-0.009104195,
0.0030202062,
-0.0024235395,
-0.010800338,
-0.007870637,
0.016599402,
-0.02721873,
-0.00064024347,
0.018476555,
0.017591612,
-0.008474008,
0.007703034,
-0.0098483525,
0.0069454685,
-0.030892586,
0.0035364234,
0.004112978,
-0.0007567276,
0.030758504,
-0.00022773059,
-0.008587978,
0.021761574,
0.0041029216,
0.004082809,
-0.049985923,
-0.006462772,
0.0036973224,
-0.009855057,
0.012214907,
0.003060431,
0.0065566297,
-0.013723334,
-0.017819552,
-0.005007978,
0.017618429,
0.012261836,
0.00367721,
0.011061799,
-0.0015168072,
0.0066739516,
0.0065566297,
0.0362827,
0.0021419665,
0.02072914,
0.03437873,
0.0022291201,
0.006177847,
-0.009801424,
0.0038146444,
-0.006925356,
0.005426985,
0.02614607,
0.032152962,
0.01798045,
0.023182848,
-0.005400169,
-0.021774983,
0.014869739,
-0.007917566,
0.01261045,
-0.026387418,
-0.0024822005,
-0.025408616,
0.05931806,
0.037543073,
0.004052641,
-0.011691986,
-0.0021402903,
-0.007998016,
0.0077164425,
0.015513334,
-0.0033721726,
-0.0058191763,
-0.012945657,
-0.013126668,
-0.006690712,
0.0047733337,
0.020286668,
-0.023973934,
-0.007703034,
0.02476502,
0.014051836,
0.010103109,
-0.0073611243,
-0.0047096447,
-0.028693635,
-0.0038381089,
0.013696518,
0.018637454,
-0.0051219477,
0.00823266,
0.010123222,
0.008728765,
0.035531837,
-0.012416031,
-0.010337753,
0.049583673,
-0.001336634,
0.005473914,
-0.010713184,
0.023652136,
0.012824982,
0.017189365,
-0.005185637,
0.008581274,
-0.009781311,
0.011906518,
-0.022767194,
-0.0139177535,
-0.015245169,
-0.017470937,
-0.0023699065,
0.0193615,
0.031348467,
0.01799386,
0.012972473,
-0.01981738,
0.021292286,
-0.018463148,
0.010954533,
-0.012416031,
-0.010679664,
-0.024121424,
-0.0145077165,
0.0083064055,
-0.013019402,
0.012570226,
0.0192006,
-0.03909843,
0.00095030904,
0.03330607,
0.017631836,
0.002059841,
0.0073276036,
0.009479626,
-0.018530188,
-0.028988617,
0.02780869,
0.022378353,
0.0053197197,
-0.0145077165,
-0.029256782,
0.013388128,
0.0020179402,
0.031563,
0.010626031,
0.01002266,
0.006797978,
0.011142248,
-0.009868465,
-0.012335582,
0.018396106,
-0.0046426035,
0.008561161,
0.012637267,
-0.0017715638,
0.008286293,
-0.016518952,
0.0018805057,
0.03467371,
0.01875813,
0.004525281,
0.00032913042,
0.0030788672,
0.003844813,
0.0029162923,
-0.017108915,
-0.00037249769,
-0.00758236,
0.02453708,
0.0016986565,
0.0216409,
0.016974833,
0.024094608,
-0.009895282,
-0.0229415,
-0.020554833,
-0.00044791904,
-0.03413738,
0.013998203,
0.00545045,
-0.0006176171,
0.013837304,
0.009010337,
0.0037442513,
-0.022217454,
0.0017363671,
0.028666819,
0.0061577344,
-0.03376195,
0.016036255,
-0.005182285,
0.013334495,
0.01988442,
0.03429828,
-0.0003293399,
0.00899693,
-0.012583634,
0.017015057,
0.008708652,
0.003065459,
0.033279255,
0.01973693,
0.0054940265,
0.0023531462,
-0.012637267,
0.000013657026,
0.0043174536,
-0.008386855,
-0.00998914,
0.015151312,
0.011571311,
0.027620975,
-0.010190263,
-0.018409515,
-0.022780601,
-0.004498465,
0.021010714,
-0.015955806,
0.028130488,
0.014829515,
0.0024235395,
-0.0034995507,
0.025717005,
-0.013347903,
-0.0033135114,
0.01988442,
0.0013039514,
-0.0098483525,
0.04290637,
-0.013877529,
-0.018329065,
-0.030302623,
0.008809214,
0.015178128,
-0.00023611073,
0.004565506,
-0.0029280246,
0.007441574,
0.012925544,
-0.028854534,
-0.011457342,
-0.0072806748,
-0.031455733,
-0.0008409481,
-0.019079927,
0.006251592,
-0.04062697,
-0.02126547,
-0.0026766201,
-0.020715732,
-0.02064869,
0.004022472,
-0.01646532,
0.00567839,
0.019803971,
-0.018798353,
0.040519703,
0.012811574,
-0.010552285,
0.011041686,
0.0012570226,
-0.041619178,
0.018007267,
0.012054008,
0.014909964,
-0.013770264,
-0.03376195,
0.0063219853,
0.019321274,
-0.004521929,
-0.0068113864,
0.022204047,
-0.006402435,
-0.0041263863,
0.025743822,
0.028934984,
-0.016344646,
-0.02042075,
-0.006563334,
-0.03786487,
-0.02354487,
0.011215993,
-0.012677492,
-0.037703972,
0.008950001,
0.0030453466,
0.0047565736,
0.0021838672,
0.026011987,
-0.03405693,
-0.0012167979,
0.007139888,
0.016170338,
0.038991164,
-0.008983522,
0.004769982,
0.042504124,
0.008111985,
-0.007904158,
-0.015271986,
0.03475416,
0.025810864,
-0.015044046,
-0.00015419477,
0.006114158,
-0.018047491,
-0.025502473,
-0.026789665,
0.0080918735,
0.008051649,
0.0011304823,
-0.007086255,
-0.01867768,
0.011772435,
0.024791837,
0.021453185,
-0.007703034,
-0.025167268,
0.00026627927,
0.024979552,
-0.022458803,
-0.01147075,
0.0157815,
-0.03542457,
-0.018811762,
0.024563897,
0.0144004505,
-0.013200413,
-0.017765919,
0.0062180716,
-0.032501575,
-0.0059297946,
-0.011222698,
-0.0049845134,
0.012342285,
-0.016438503,
0.041109666,
0.039205696,
0.03137528,
-0.005018034,
0.013609365,
0.014440675,
0.0012302061,
0.0056683337,
-0.0026028748,
0.03805259,
-0.021694534,
0.0026397475,
0.0042034835,
0.0022978373,
0.008581274,
-0.018570414,
0.016411686,
0.027915956,
-0.013153484,
-0.010505357,
-0.0013064655,
-0.012255132,
-0.028988617,
0.011953447,
-0.02004532,
0.0072739706,
-0.031080302,
-0.010310937,
0.026883522,
0.012550114,
-0.004790094,
-0.011578016,
0.019079927,
0.008862847,
0.008480712,
0.0079309745,
-0.0096874535,
-0.013904345,
-0.017242998,
-0.00007055039,
0.017055282,
-0.016948016,
0.00724045,
-0.016948016,
0.01996487,
-0.020393934,
-0.0027000846,
0.0057320227,
-0.0064191953,
-0.024523672,
-0.016183747,
-0.022820825,
-0.01996487,
-0.0077164425,
-0.018436331,
-0.015996031,
0.0037073786,
0.012107641,
-0.006281761,
0.016036255,
-0.014856331,
-0.014990414,
0.04223596,
0.004401255,
0.001558708,
-0.046821576,
0.022431986,
0.015647417,
-0.007294083,
-0.011195881,
-0.0031542885,
-0.0077164425,
-0.021842023,
0.017819552,
0.027446669,
-0.006402435,
0.0036269291,
0.032501575,
0.0029749535,
0.0049845134,
-0.031348467,
0.014802698,
0.0044582402,
-0.0026045507,
-0.026226519,
-0.010646143,
-0.022874458,
-0.002998418,
-0.030356256,
0.011376892,
-0.005185637,
0.000027183112,
-0.0065432214,
0.013166892,
-0.01150427,
0.008292997,
-0.012141162,
-0.012845094,
-0.012617154,
-0.033037905,
-0.01744412,
0.014333409,
-0.010605918,
0.00480015,
0.0009804775,
-0.0035565358,
0.017350264,
0.019991687,
0.014896556,
-0.0035934085,
0.0043677343,
0.038642548,
-0.01177914,
0.014883148,
0.01299929,
-0.006854963,
-0.017242998,
-0.021989515,
0.009969027,
-0.009895282,
-0.0016592698,
-0.0005124462,
0.017336855,
0.02149341,
0.0007596606,
0.010230487,
-0.032796558,
-0.0040794574,
-0.023142623,
-0.039125245,
0.009694158,
-0.02316944,
0.016599402,
0.0026883523,
0.00078731513,
0.02300854,
0.013542323,
0.0070996634,
-0.008212548,
0.017162548,
-0.017323447,
0.023142623,
0.0029933897,
-0.0068784277,
-0.03024899,
-0.0072605624,
-0.002505665,
-0.044086296,
0.009385768,
-0.01368311,
-0.026870115,
-0.011061799,
-0.0026330433,
-0.006566686,
-0.0040928656,
-0.03276974,
0.011886406,
0.0011472426,
0.039178878,
-0.005413577,
-0.00344927,
0.05390113,
-0.035183225,
-0.024429815,
0.018811762,
0.00025559458,
-0.0071063675,
-0.023518054,
0.0008296349,
-0.0014087033,
0.0034827904,
-0.033225622,
-0.001063441,
-0.010652848,
-0.014494308,
-0.0015193212,
-0.012731125,
-0.009204757,
-0.011571311,
-0.012033896,
-0.0032498224,
-0.0052694385,
-0.0023196256,
-0.0077231466,
-0.022619702,
0.023732586,
-0.025314758,
0.013093147,
-0.005118596,
-0.023571687,
-0.034968693,
-0.005913034,
-0.04373768,
0.028988617,
-0.0070661427,
0.018194983,
-0.0065398696,
0.00063940545,
-0.052077606,
-0.0011564607,
0.007394645,
0.0017765919,
0.0030336145,
0.022619702,
0.0017631836,
0.014695432,
0.0011991996,
0.04223596,
0.011537791,
-0.02035371,
0.011028278,
-0.0022911332,
0.038615733,
-0.0074885027,
-0.010176855,
-0.00925839,
-0.0046124347,
0.019455357,
0.005953259,
0.018020675,
-0.020192811,
-0.017497754,
-0.00880251,
0.002783886,
-0.016572585,
0.005943203,
-0.026360601,
-0.017779328,
-0.0063253376,
0.0113903005,
0.0036101688,
0.015137903,
-0.008929889,
0.0144809,
-0.012315469,
0.009157828,
-0.0042269477,
-0.013274158,
0.003393961,
-0.020890038,
0.012650675,
0.010793634,
0.003509607,
0.013549027,
-0.0025542697,
0.0067141764,
-0.011859589,
-0.0059398506,
-0.0023598503,
-0.0019307866,
-0.0010910956,
0.01623738,
-0.0077700755,
-0.009560076,
-0.012744533,
-0.029095883,
0.002609579,
-0.01768547,
-0.004716349,
-0.037221275,
0.033922847,
0.005356592,
-0.016974833,
-0.006137622,
0.023451013,
-0.02780869,
-0.011215993,
0.0053197197,
0.021694534,
-0.008621499,
-0.012925544,
-0.018691087,
-0.017310038,
0.0021821912,
-0.013481986,
-0.018315656,
-0.01394457,
0.010109814,
0.18052855,
-0.008205843,
-0.007461686,
0.0057253186,
-0.0034827904,
0.0022458804,
0.031107118,
0.00025412807,
-0.017323447,
0.015714457,
0.028908167,
-0.024872286,
0.031589814,
0.009546667,
0.0027218729,
-0.0023799627,
-0.015245169,
-0.01630442,
-0.0008497473,
-0.0049979216,
0.0124830725,
-0.0029146164,
0.025851088,
0.0067812176,
0.035317305,
-0.008990225,
-0.012657379,
0.022633111,
0.0016341293,
0.0052526784,
-0.004723053,
0.002512369,
0.0020833055,
0.013575844,
0.0102975285,
-0.0104584275,
-0.015714457,
-0.041190114,
0.0027436612,
0.017859777,
0.017645245,
-0.024027567,
-0.023518054,
-0.0109411245,
-0.019160377,
0.016948016,
0.0022157119,
-0.021077754,
-0.0019592792,
-0.008373447,
-0.030463522,
-0.008728765,
0.009003634,
0.015124495,
0.0083600385,
-0.016170338,
0.039607942,
0.0076561053,
-0.009318727,
0.016022848,
-0.008815918,
-0.000107004045,
-0.024014158,
0.037301727,
-0.002832491,
0.032903824,
-0.011678577,
0.0024620881,
0.0035196631,
-0.013153484,
0.013877529,
-0.01568764,
-0.011705394,
-0.0063957307,
0.008567866,
-0.017618429,
0.004780038,
-0.00031362713,
0.012094233,
0.008554458,
-0.0039185584,
-0.0105120605,
-0.010270712,
0.0017413952,
-0.012965769,
-0.026910339,
0.027111463,
0.011678577,
-0.036711764,
-0.006285113,
0.0014950188,
-0.006787922,
-0.009352248,
0.0117120985,
0.02056824,
0.015955806,
0.02644105,
-0.009412585,
0.016130114,
-0.018583821,
-0.0064728283,
0.06929379,
0.026280152,
0.006285113,
-0.013616068,
0.010605918,
-0.013730039,
0.00914442,
0.008775693,
-0.025314758,
0.03276974,
-0.018784946,
0.00041900753,
-0.01085397,
-0.011678577,
0.010713184,
0.018583821,
-0.011671874,
-0.0031894853,
0.0048705433,
-0.020635283,
-0.028371837,
0.006640431,
0.024175057,
0.009124308,
-0.02111798,
-0.03421783,
0.005859401,
-0.0051755807,
-0.025408616,
-0.012469664,
-0.01934809,
-0.001226016,
0.02492592,
0.00968075,
0.009700862,
0.014829515,
-0.019750338,
-0.009365656,
-0.0017732398,
-0.0017330151,
-0.00012161693,
0.0023866668,
-0.0076695136,
0.0060571725,
-0.0138641205,
0.017806144,
0.031723898,
-0.04261139,
-0.0072806748,
-0.019683298,
-0.036014535,
-0.02111798,
-0.015875356,
0.023571687,
-0.018329065,
-0.01706869,
-0.0077834837,
0.00956678,
0.013314383,
-0.02614607,
0.007535431,
0.008266181,
-0.0015696022,
0.018865395,
-0.003620225,
-0.1684075,
0.00925839,
0.010599215,
-0.018610638,
0.028720452,
0.034700528,
0.005752135,
-0.011591424,
-0.033118356,
0.016746894,
0.030731687,
0.009486331,
-0.039876107,
-0.0012964093,
-0.008655019,
-0.0026011986,
0.00044917606,
0.012201499,
0.022472212,
0.012308765,
0.020769365,
-0.0117657315,
0.006844907,
-0.015835132,
0.0029079122,
0.01539266,
0.007951086,
-0.0012411003,
-0.0021335862,
-0.03032944,
-0.025207493,
0.010230487,
0.008373447,
-0.0006536517,
0.0071130716,
0.01299929,
-0.0058828657,
0.014534533,
-0.0035800003,
0.026561724,
0.004354326,
0.016411686,
0.009801424,
0.00025370906,
-0.010659551,
0.044461727,
0.009995843,
-0.010518765,
-0.004394551,
-0.012476368,
0.03317199,
0.013475282,
0.028934984,
0.003673858,
0.0007596606,
0.019656481,
0.0031123878,
0.016116705,
0.0072069294,
-0.0012126077,
0.0011556228,
-0.03625588,
-0.00567839,
0.012308765,
0.011993672,
-0.016210563,
-0.010217079,
-0.001615693,
-0.010485244,
0.019803971,
-0.021278879,
-0.0011480806,
0.010927716,
-0.021386145,
0.0265215,
0.010974645,
0.00588957,
0.013703222,
0.0057789516,
-0.0029263485,
-0.017765919,
0.018932436,
-0.019106744,
-0.01059251,
-0.033413336,
0.02370577,
-0.0067175287,
0.013160189,
0.008520937,
-0.02149341,
0.0010919336,
-0.01820839,
-0.013716631,
-0.017323447,
-0.012824982,
0.062375136,
-0.011718802,
-0.018463148,
-0.026695807,
0.0028844478,
0.007501911,
-0.012167978,
-0.026172886,
0.012764645,
-0.01568764,
-0.0053599444,
-0.022606295,
-0.006469476,
0.03504914,
-0.02110457,
0.000056827896,
-0.00872206,
0.03024899,
0.005789008,
-0.011135544,
-0.00046048927,
0.019535806,
-0.0029112643,
0.010652848,
-0.0056616296,
0.0480015,
-0.005132004,
-0.02149341,
0.011370189,
-0.010646143,
-0.0014849626,
-0.13579866,
0.004022472,
-0.019562623,
0.007186817,
-0.01417251,
0.026856706,
-0.0054873223,
0.019750338,
0.0015779823,
0.027165096,
-0.01623738,
-0.00234309,
0.0019274346,
0.0028861237,
-0.004622491,
-0.0058862176,
-0.004414663,
-0.0104047945,
-0.028613186,
0.024657754,
0.005752135,
0.006794626,
-0.01814135,
-0.030275807,
0.019589439,
-0.005845993,
-0.017310038,
0.021158203,
0.001002266,
0.01576809,
0.006127566,
0.0067577534,
0.017645245,
0.003442566,
-0.011014869,
0.008836031,
-0.010424907,
-0.0055543636,
0.0460439,
-0.019656481,
-0.01261045,
0.0120406,
-0.015835132,
0.0015771443,
0.019120151,
-0.0019860957,
-0.0140786525,
0.006854963,
0.01631783,
-0.02355828,
-0.039500676,
-0.036845844,
-0.033949666,
0.017082099,
0.016746894,
-0.03032944,
-0.010927716,
0.039286144,
-0.04829648,
-0.006298521,
-0.0110483905,
0.00037040265,
0.0057487832,
0.0036537456,
0.04314772,
-0.016948016,
-0.013394833,
-0.01913356,
0.013193709,
-0.031268016,
-0.002111798,
-0.01615693,
-0.03137528,
-0.011631649,
-0.022552662,
0.00546721,
0.004793446,
-0.014360226,
-0.015634008,
-0.01158472,
-0.01700165,
0.0013693166,
0.00876899,
0.012114345,
0.060766146,
0.017618429,
-0.003176077,
-0.015245169,
0.00257103,
-0.012744533,
-0.0062616486,
0.02888135,
0.0016978185,
-0.01737708,
0.0043710866,
0.01394457,
-0.017122323,
-0.03263566,
0.019750338,
0.03276974,
-0.01272442,
-0.02064869,
-0.06081978,
0.019214008,
-0.017390488,
-0.00007405958,
0.0003737547,
-0.010123222,
-0.0018436331,
-0.0010843915,
0.019951463,
0.020755956,
-0.0064862366,
0.01737708,
-0.010766817,
0.015486518,
-0.03901798,
-0.01798045,
0.0024654402,
-0.014923372,
0.025073411,
0.016720077,
-0.009533259,
-0.013481986,
0.012892024,
0.025502473,
0.006630375,
0.022445396,
-0.007522023,
0.029819928,
-0.004300693,
-0.015070862,
0.004176667,
-0.044166744,
-0.008024832,
0.008728765,
-0.003179429,
-0.023410788,
0.0034928466,
0.04293319,
-0.009506443,
0.019468766,
-0.0006239022,
-0.039715208,
0.017269814,
0.014105469,
-0.001396971,
-0.03185798,
-0.03032944,
0.009191349,
0.006616967,
-0.01677371,
0.031455733,
-0.014735657,
-0.0016039608,
-0.029471314,
-0.007139888,
-0.0116048325,
0.011303147,
-0.021909066,
-0.0017732398,
0.006402435,
0.009204757,
0.017551387,
0.02279401,
-0.017926818,
0.005018034,
-0.014306593,
-0.02476502,
-0.00030838954,
-0.008292997,
-0.005527547,
-0.016022848,
0.023813035,
-0.024201874,
0.00031383664,
-0.0074348697,
0.007287379,
0.004277229,
0.011484158,
0.0019559271,
0.0014849626,
-0.011752323,
0.0060001877,
-0.0182218,
0.002944785,
0.021480002,
0.000005797362,
-0.011276331,
0.033118356,
-0.018530188,
0.00017441188,
-0.011624944,
0.013783672,
0.027419852,
0.010860675,
0.0066638957,
0.02186884,
0.015124495,
-0.014266368,
0.0058795135,
0.03169708,
0.012503184,
-0.0032196539,
0.0075622476,
-0.020769365,
-0.006791274,
0.03703356,
-0.044327643,
-0.010605918,
-0.0008715356,
0.013274158,
0.031965245,
-0.0015913906,
0.0067275846,
0.0010525469,
-0.005061611,
-0.0021101218,
-0.0110483905,
0.017417304,
-0.01615693,
0.011564608,
-0.004639251,
0.02850592,
-0.0050984835,
0.0021821912,
0.00038862947,
0.0037677155,
0.018355882,
-0.01913356,
0.023263298,
0.021895656,
0.0019592792,
0.017175956,
-0.05274802,
0.0022492325,
0.0005698502,
-0.015204945,
0.037221275,
0.0030000939,
-0.020152586,
0.08447192,
0.004575562,
-0.027996406,
0.015660824,
-0.027755057,
0.001505913,
-0.006221424,
0.014977005,
0.021506818,
-0.03507596,
0.009553372,
0.009962323,
0.027755057,
-0.041511912,
-0.047572438,
0.0021788392,
-0.025019778,
-0.01150427,
0.025167268,
-0.028318204,
0.011343372,
0.018087717,
0.004401255,
0.022874458,
-0.017041873,
-0.0020916855,
0.019120151,
-0.0076158806,
-0.0059633153,
-0.03574637,
0.026963972,
-0.011262923,
-0.030517155,
-0.025690189,
-0.009888577,
-0.01874472,
-0.036336333,
-0.030624421,
-0.003342004,
0.0072069294,
-0.036684945,
0.0140786525,
-0.016585995,
-0.022726968,
0.002059841,
-0.012550114,
-0.01942854,
-0.008587978,
-0.036845844
] |
The mammalian radiation has corresponded with rapid changes in noncoding regions of the genome, but we lack a comprehensive understanding of regulatory evolution in mammals. Here, we track the evolution of promoters and enhancers active in liver across 20 mammalian species from six diverse orders by profiling genomic enrichment of H3K27 acetylation and H3K4 trimethylation. We report that rapid evolution of enhancers is a universal feature of mammalian genomes. Most of the recently evolved enhancers arise from ancestral DNA exaptation, rather than lineage-specific expansions of repeat elements. In contrast, almost all liver promoters are partially or fully cons
|
[
-0.014794575,
-0.0066919955,
0.0026373945,
-0.044820808,
-0.022873975,
0.006599281,
-0.035072546,
-0.0010165476,
-0.027364003,
-0.0033410308,
0.005920479,
-0.0017665412,
0.020105788,
-0.015549535,
-0.0036622202,
0.02396006,
0.03276793,
-0.013536308,
-0.009198597,
0.0069800727,
-0.02213226,
-0.0010736663,
-0.005990015,
-0.012834327,
-0.00821185,
0.011377386,
0.014940269,
-0.040132105,
-0.01561576,
-0.020794524,
0.015496556,
0.011648906,
-0.011205202,
-0.005274789,
-0.0033228192,
0.0016415422,
0.0008907208,
-0.01071514,
0.014092594,
-0.013125715,
0.013602532,
0.017059457,
0.0022135573,
-0.004364201,
-0.0076290737,
-0.0035330823,
0.0065893475,
-0.01036415,
-0.018317724,
0.018330969,
-0.008887341,
-0.011125732,
0.00430791,
-0.005658892,
-0.02943021,
0.0024171977,
-0.0013335978,
0.030224906,
-0.004970156,
-0.011423743,
-0.007662186,
0.0014519743,
-0.030940132,
0.020317707,
0.0015711786,
0.034092423,
-0.013629022,
0.003890695,
0.011304539,
-0.004642344,
0.04765522,
0.0053112125,
-0.026820961,
0.0022648813,
0.007086032,
-0.016489925,
-0.018807786,
2.9102605e-7,
-0.011589305,
-0.002867525,
0.02140379,
-0.020198502,
-0.008913831,
0.007622451,
0.009145617,
0.02033095,
0.004728436,
0.0008406385,
0.012337643,
0.017589252,
0.015311127,
0.033589117,
0.0430195,
0.029218292,
-0.0011415465,
-0.017112436,
0.032185156,
0.0031738137,
0.0021175314,
-0.016119067,
-0.023973305,
0.0077615227,
-0.0043377113,
-0.00043997966,
-0.027337514,
0.007132389,
0.011278049,
-0.0058277645,
0.009509852,
-0.017840907,
-0.005692004,
0.038701653,
-0.0027565989,
-0.029986497,
0.03615863,
-0.022609077,
0.00066762674,
0.0011738309,
0.0061986223,
0.0015115765,
0.016794559,
0.03131099,
0.0014718417,
-0.025059387,
0.009344291,
0.00084933045,
-0.004480094,
0.0022367358,
-0.018556133,
0.0018476662,
0.0220263,
-0.029138822,
0.019774664,
0.019761419,
-0.03743014,
0.016463434,
0.0007934534,
-0.010191966,
0.007986686,
-0.039655287,
-0.00086009194,
0.011814468,
-0.022542853,
-0.008609198,
-0.0019370695,
0.022715036,
0.013026378,
-0.012198571,
0.012364132,
0.007913839,
0.013907165,
-0.0008501583,
0.020662075,
0.008569463,
0.011284672,
0.002158922,
-0.030224906,
0.008516483,
-0.011198579,
-0.025893817,
0.028370617,
-0.014119084,
0.010761497,
0.010993283,
0.01109262,
0.035284463,
0.041483086,
-0.00047805882,
0.0020215057,
-0.014900534,
-0.011715131,
0.0045032725,
-0.02221173,
0.011436988,
-0.036635447,
0.018662091,
-0.027496453,
0.023059405,
-0.0132449195,
0.009887332,
0.00904628,
0.0053377026,
0.035072546,
0.016357476,
-0.006559546,
0.0018592556,
0.0045463187,
-0.018993214,
0.013629022,
-0.032556012,
-0.0057847183,
0.020887237,
-0.0034403678,
-0.01655615,
-0.63363695,
-0.0086754225,
0.01631774,
-0.033986464,
0.0036390417,
0.0035926844,
0.0102317,
-0.00089899893,
-0.009456872,
0.015364107,
-0.033695076,
0.0076158284,
0.039681777,
-0.031787805,
-0.030489804,
-0.03949635,
-0.0074105323,
0.0007971786,
0.021920342,
0.0038211592,
-0.017218396,
-0.0009089326,
0.019946849,
0.012595918,
0.016569395,
0.01819852,
0.002829446,
0.022224974,
0.018569376,
0.04296652,
-0.03268846,
0.023138873,
-0.01819852,
0.0016481647,
0.04882077,
-0.008145626,
-0.0023013048,
0.021960076,
0.019165399,
0.04402611,
0.018158784,
0.0031224897,
0.026926922,
0.019138908,
-0.010344282,
0.0053377026,
0.01058269,
-0.0019619036,
0.015430331,
0.0013576043,
-0.018609112,
0.012125724,
-0.028503066,
0.0018476662,
-0.0052946564,
0.0073575526,
0.015390596,
-0.015152188,
0.009589322,
0.0028046116,
-0.0027416984,
0.013907165,
-0.011019773,
-0.008635688,
-0.023933569,
0.0030496428,
-0.0067946436,
0.019390563,
-0.0025827594,
-0.014145574,
0.016119067,
0.018768052,
0.015629005,
-0.012119101,
0.0036257966,
0.014662126,
0.0030794437,
-0.010225078,
0.0070794094,
0.02552296,
0.010562823,
-0.0042284406,
-0.025761368,
-0.0040397006,
0.016728332,
-0.024887204,
-0.021152137,
0.009675413,
0.014927024,
0.0065198117,
0.011231692,
-0.0040926803,
-0.027152084,
-0.019536257,
-0.0312845,
0.013503196,
0.010331037,
0.03438381,
-0.010384017,
-0.030807683,
-0.027761351,
0.0072847055,
0.024251448,
-0.0010033026,
0.0062946477,
0.006211867,
-0.050463144,
-0.0068939803,
0.038357288,
-0.0097283935,
0.0065761027,
-0.010629048,
0.005821142,
0.003336064,
-0.0148608,
-0.02135081,
0.01467537,
0.023509732,
-0.032158665,
-0.02573488,
0.025006408,
0.0138276955,
0.015112453,
-0.015761454,
0.038012918,
0.021655444,
-0.002966862,
-0.013344256,
0.0015869068,
0.010033026,
0.016993232,
-0.0051622074,
0.030675232,
-0.035390425,
0.024542836,
0.01806607,
0.03499308,
0.010198588,
0.0012119102,
-0.012576051,
-0.0278938,
-0.0037681796,
-0.020450156,
0.006238357,
-0.022741526,
-0.036847364,
-0.02382761,
0.02299318,
0.0030065966,
-0.0035761283,
0.0012781348,
0.005258233,
-0.009304556,
0.006599281,
0.023231588,
-0.0038840726,
0.0020777967,
-0.032052703,
-0.015734965,
-0.013417103,
-0.0031721583,
0.019589236,
-0.0098608425,
0.015165432,
-0.0037681796,
-0.0164237,
-0.0012433669,
0.0019337583,
-0.0029999742,
-0.02546998,
-0.0017284619,
-0.018728316,
-0.018781295,
0.0010190309,
0.027416984,
-0.009013168,
-0.0068343785,
-0.019827643,
-0.021006443,
-0.0028393795,
0.00072764274,
-0.0047483034,
0.007132389,
-0.016993232,
0.0458804,
0.023284568,
0.03131099,
0.023522977,
0.0019503144,
0.016913762,
-0.00017270133,
0.01957599,
-0.011185334,
0.00055173365,
0.00452314,
-0.020198502,
0.008503239,
0.0010173754,
0.0078012575,
0.017032966,
0.02124485,
-0.012383999,
0.003344342,
-0.03109907,
0.009880709,
-0.024344161,
-0.007086032,
-0.005893989,
-0.0075959614,
0.00003590615,
-0.004801283,
-0.004410558,
-0.005506575,
-0.009781373,
-0.012476714,
0.007072787,
-0.013178695,
-0.006788021,
-0.012225061,
-0.01884752,
-0.0010057861,
-0.01233102,
0.011436988,
0.0012350887,
0.0232051,
0.02033095,
-0.014225043,
0.030913642,
-0.006986695,
-0.013907165,
-0.011185334,
0.017271375,
-0.0064999443,
0.007258216,
0.026224941,
-0.0041555935,
0.00092714437,
-0.013238297,
0.009801241,
0.0025562695,
0.01569523,
0.00035036952,
-0.0026854074,
-0.012953531,
0.021986566,
-0.0127747245,
0.0002785572,
0.0048741302,
-0.02218524,
-0.0013782994,
0.0010074417,
0.01192705,
-0.013278032,
0.013470083,
0.037297692,
-0.020066053,
0.013509817,
-0.003645664,
0.026224941,
0.025814347,
0.010701895,
0.0025165346,
-0.009377403,
-0.0406619,
0.005417172,
-0.0071191443,
0.02048989,
0.0018112428,
0.013026378,
-0.0023791187,
-0.0075628487,
-0.007105899,
0.0040297667,
-0.028926903,
0.022542853,
0.0052516107,
0.0018758117,
0.017377334,
0.0025960042,
0.006456898,
-0.011417121,
-0.034251362,
0.03276793,
0.02802625,
-0.019907113,
-0.0010728384,
-0.048449915,
-0.026397124,
-0.011986652,
-0.005499953,
0.016158802,
-0.0010355872,
-0.014198554,
0.00007786564,
-0.014609146,
-0.011291293,
0.02546998,
-0.025205081,
0.027046125,
-0.0141853085,
0.0012326053,
-0.0042747976,
-0.015907148,
0.0024105753,
0.041403618,
0.00020757272,
0.0059999484,
-0.02194683,
-0.013695247,
-0.012158836,
-0.011794601,
0.000045684625,
0.011059508,
-0.02458257,
-0.016278006,
0.017244885,
-0.004003277,
0.016304495,
0.0002442032,
0.013099225,
-0.021059422,
-0.028609026,
-0.011211825,
0.00452314,
0.028476577,
0.008390657,
-0.0015529668,
0.017364088,
0.010350904,
0.007059542,
-0.021032931,
-0.012238305,
0.0229402,
-0.0021224984,
-0.025297796,
0.007900595,
-0.00052648556,
0.0010521433,
0.030012988,
0.010105873,
0.0044900277,
-0.06426435,
-0.029801069,
-0.009721771,
0.011761488,
-0.0035926844,
0.03160238,
0.029827558,
0.01725813,
-0.0021423658,
0.0018774673,
0.028609026,
0.0066655055,
-0.021655444,
-0.008019798,
0.028158698,
-0.008927075,
0.029085843,
0.029774578,
-0.015787944,
0.03586724,
0.0011804535,
0.026039511,
0.0036655315,
0.02805274,
0.02708586,
0.025165347,
0.013562798,
0.011787978,
-0.0022417025,
-0.002915538,
0.02132432,
-0.0063741175,
-0.015205167,
0.008933698,
-0.014423717,
-0.024979917,
-0.011701887,
0.017350845,
0.008860851,
-0.008701912,
-0.019284602,
-0.007059542,
-0.020092543,
-0.0064602094,
-0.011814468,
-0.009953557,
-0.001289724,
-0.0032979848,
-0.019602481,
-0.020317707,
-0.014874045,
-0.02940372,
0.008536351,
0.005188697,
-0.024079263,
-0.02619845,
-0.004784727,
0.02280775,
0.021377299,
0.00945025,
-0.04452942,
0.017191906,
0.03247654,
0.0039502974,
-0.010960171,
0.0061158417,
-0.032556012,
-0.011297916,
-0.010840966,
0.004867508,
-0.020582605,
-0.0068807355,
-0.015032983,
0.009350913,
-0.029218292,
0.020940218,
0.008999922,
-0.00024999786,
0.013496573,
0.0074370224,
0.041377127,
0.009569454,
-0.0013145582,
0.0024900448,
-0.013774716,
-0.027258044,
-0.025748122,
0.00003947607,
-0.006814511,
0.013410481,
-0.0059403465,
-0.037138753,
-0.024701774,
0.01268201,
-0.0022036235,
0.0025612363,
0.014569411,
0.018728316,
0.0070926542,
0.00452314,
0.003658909,
-0.01313896,
-0.026569309,
-0.0071390118,
-0.011099243,
0.037059285,
-0.0076092063,
-0.011423743,
0.03448977,
0.0034933474,
0.004642344,
-0.022595832,
-0.0054635294,
0.013655512,
0.04765522,
-0.0047814157,
-0.028635515,
-0.013814451,
0.005744984,
-0.0045363847,
-0.0001285171,
-0.02377463,
-0.00037727325,
-0.03329773,
0.010006537,
0.005228432,
-0.017801171,
0.0017052834,
-0.035973202,
-0.005662203,
0.009834353,
-0.005718494,
-0.0037714909,
-0.015946884,
-0.015602515,
-0.010344282,
-0.014489942,
-0.02466204,
-0.015284637,
0.002266537,
-0.012801214,
0.021046177,
0.021536238,
0.039814226,
-0.0053675035,
0.0013418759,
0.023536222,
0.019615725,
0.006615837,
-0.014648881,
0.019880624,
-0.0042019505,
0.00823834,
-0.0004066604,
0.0042350627,
0.0018244877,
0.0006138192,
0.027840821,
0.027575921,
-0.01731111,
-0.02792029,
-0.0072251037,
-0.05115188,
-0.031920254,
0.006695307,
-0.010973415,
0.0045032725,
-0.030754702,
-0.024463367,
0.032158665,
-0.0032003035,
0.029244782,
-0.020741543,
0.014728351,
-0.0085628405,
0.03109907,
0.008814494,
-0.009456872,
0.0032152042,
-0.010814477,
-0.013960145,
-0.018688582,
0.018741561,
0.00912575,
0.03250303,
0.009807862,
-0.015191923,
-0.006456898,
0.015496556,
-0.019483276,
0.0020347508,
-0.02539051,
-0.019072684,
0.003427123,
-0.024966672,
0.009384026,
-0.02396006,
-0.00096853473,
0.0052946564,
-0.0023807744,
0.021138892,
-0.0024966672,
-0.015999863,
0.023496486,
-0.0018311101,
0.028847434,
-0.013734981,
0.022277955,
0.027152084,
0.004003277,
-0.03499308,
-0.033880502,
-0.0067946436,
-0.00011113315,
0.03769504,
0.0040297667,
-0.0010380705,
0.006427097,
0.0151256975,
0.011781355,
-0.025032898,
-0.046754565,
0.020940218,
-0.026887186,
-0.008112513,
-0.007821125,
-0.0059237904,
-0.015854169,
0.0000035343498,
-0.0026092492,
0.010119119,
0.007490002,
-0.025695143,
0.0033228192,
0.03769504,
0.013185318,
0.009648924,
-0.021562729,
-0.016026352,
0.00850986,
-0.0049867122,
-0.00063865347,
-0.01723164,
-0.0085628405,
0.029006373,
-0.017271375,
-0.011225069,
0.028688496,
0.0046324106,
-0.010271435,
-0.0041721496,
0.02135081,
0.041403618,
-0.010271435,
0.00027400427,
0.015761454,
0.008377411,
0.006559546,
0.009489985,
-0.008079401,
-0.0072847055,
-0.01911242,
0.03287389,
0.015178678,
0.023734896,
-0.009238332,
-0.004612543,
-0.015708474,
0.009953557,
-0.02948319,
-0.035204995,
0.004162216,
-0.030595765,
0.0035463271,
0.013814451,
0.019046195,
0.01973493,
0.025695143,
0.0010182032,
-0.013854186,
0.038569205,
-0.0067217965,
0.026052756,
0.008006554,
-0.002821168,
-0.043284398,
0.0067052403,
-0.032105684,
-0.017814416,
-0.0110263955,
-0.03287389,
-0.039204963,
0.0017350845,
0.0004921315,
0.017668722,
0.0049900236,
0.0011721754,
-0.0036489754,
-0.0012301219,
0.023509732,
-0.021046177,
-0.022834241,
0.019602481,
-0.03973476,
0.00034850693,
0.016383965,
0.0026026266,
-0.0016175358,
-0.0106886495,
-0.033695076,
0.0061025964,
-0.007840992,
-0.009953557,
-0.013761471,
0.009364158,
-0.009946935,
0.005347636,
-0.010450241,
-0.012589295,
-0.023456752,
0.01566874,
0.012562806,
0.012092612,
-0.0035032812,
0.025681898,
0.009768128,
0.008576085,
-0.017138926,
0.0031887144,
0.007794635,
-0.013509817,
-0.048582364,
-0.013191939,
-0.015734965,
0.015907148,
0.01806607,
-0.014648881,
-0.016874027,
0.020370686,
-0.060131934,
-0.030754702,
0.0114701,
0.033695076,
0.003009908,
0.028900415,
0.014370738,
-0.0032019592,
-0.016781313,
-0.0007528909,
0.014940269,
-0.038887084,
-0.004278109,
-0.0012483336,
0.019801155,
0.011761488,
-0.02781433,
0.0038575828,
0.036582466,
-0.0077681453,
-0.02124485,
0.041483086,
-0.030277885,
0.039867207,
-0.018079314,
0.031496417,
0.0014254844,
0.023258079,
0.05101943,
-0.035019565,
-0.0071522566,
0.014529676,
-0.008569463,
-0.022039546,
0.023456752,
-0.008801249,
0.020768033,
0.02792029,
-0.010251568,
-0.020277971,
0.02948319,
-0.017907131,
0.013642267,
0.0017566074,
0.0063873623,
0.008688667,
0.0006982556,
-0.029297762,
-0.011840958,
-0.024953429,
-0.0142780235,
0.006456898,
0.020741543,
-0.016026352,
-0.007423777,
0.012145591,
-0.0034933474,
-0.019509766,
-0.010218455,
0.0033575871,
-0.021814382,
-0.0207283,
0.005635713,
-0.00786086,
-0.0057847183,
-0.021774648,
-0.0011357518,
0.0018774673,
0.009403893,
-0.0024056085,
-0.0024072642,
0.016436946,
0.023377283,
0.017483294,
-0.006364184,
-0.0041423487,
0.006513189,
-0.02455608,
-0.021734912,
0.02546998,
0.18002494,
-0.03276793,
-0.0017880641,
0.010622425,
-0.003293018,
-0.028714985,
0.01012574,
0.0053939936,
-0.012648898,
0.00048550908,
0.014344248,
0.0036257966,
-0.038436756,
0.0032748063,
0.014966759,
-0.022873975,
-0.034966588,
0.017536273,
-0.03112556,
0.015032983,
0.019059438,
-0.0053807483,
-0.024688529,
-0.0010463486,
0.024847468,
0.011794601,
-0.030436825,
-0.0017665412,
-0.0027532876,
0.01548331,
-0.023549467,
0.010344282,
-0.020476645,
0.007331063,
-0.012589295,
0.0061986223,
0.010092628,
0.0050529367,
-0.0057549174,
0.009324423,
0.001543033,
0.015734965,
0.01071514,
-0.0056390245,
0.004827773,
0.002996663,
0.012099233,
0.0020099166,
-0.014383983,
0.0036357304,
-0.029456701,
0.023231588,
0.02617196,
0.025099123,
-0.010145608,
0.0063443165,
0.010768119,
0.0075628487,
-0.00036051014,
0.02533753,
-0.016052842,
0.0033675206,
-0.020834258,
0.013099225,
-0.0119667845,
0.024834223,
-0.01389392,
-0.008854229,
0.014489942,
-0.014741595,
-0.0086688,
-0.004956911,
-0.01723164,
-0.0039105625,
-0.00038120535,
-0.011509835,
0.030516295,
0.02546998,
0.032317605,
0.01558927,
0.008728402,
-0.004903931,
-0.025509715,
-0.0017284619,
0.007840992,
-0.03120503,
0.033403687,
0.009695281,
-0.011920427,
-0.00025765508,
-0.005086049,
-0.029615639,
-0.011708509,
-0.008754891,
0.00977475,
-0.013191939,
-0.00089403207,
0.0052648555,
-0.015920393,
-0.023059405,
-0.044820808,
0.040211577,
0.0043277773,
0.007185369,
0.00656948,
0.008609198,
-0.003279773,
-0.002170511,
-0.011244937,
-0.0058906777,
0.0031953368,
-0.031681847,
0.020701809,
-0.0067615313,
-0.001836077,
0.022979936,
0.025059387,
-0.028794454,
0.043867175,
0.007059542,
-0.013562798,
-0.015377351,
0.00089320424,
0.01074163,
-0.009516475,
0.0015231657,
-0.013536308,
-0.0060098823,
-0.015244902,
-0.021854118,
-0.0032317603,
-0.0049006203,
0.010536334,
0.001302969,
-0.004682079,
-0.034251362,
-0.0050430032,
-0.0072714607,
-0.0014610802,
0.017774682,
-0.006456898,
0.002398986,
0.006013193,
0.012178703,
0.0018890566,
-0.022489874,
0.029986497,
0.02711235,
-0.00901979,
0.012337643,
-0.010099251,
-0.003890695,
-0.0039569195,
-0.0076158284,
0.043416847,
-0.022330934,
-0.008026421,
-0.04238374,
-0.003400633,
0.015629005,
-0.027364003,
0.0048343954,
0.025708389,
-0.039072514,
-0.00079635077,
0.020238237,
-0.16625023,
-0.031999726,
0.011450233,
-0.048370447,
0.007231726,
0.03949635,
0.02773486,
-0.014436962,
-0.010622425,
-0.012291285,
0.047072444,
-0.002321172,
-0.060025975,
-0.04595987,
-0.005341014,
0.0031556021,
-0.016145557,
0.02517859,
0.0028013005,
-0.008602575,
0.019668706,
-0.013158827,
0.023165364,
-0.004827773,
-0.017920377,
0.0142780235,
-0.0074304,
-0.012350887,
0.0055992897,
-0.023364037,
-0.005370815,
0.005288034,
0.016132312,
-0.02062234,
0.002162233,
0.005801275,
0.001328631,
-0.011198579,
-0.007086032,
0.0069933175,
0.003430434,
0.0061191525,
0.007185369,
-0.006066173,
0.013549552,
0.012602541,
0.003427123,
-0.004278109,
0.024516346,
0.0014792919,
0.013907165,
-0.019364072,
0.011728376,
0.005215187,
0.02080777,
0.0060297498,
-0.0018029646,
0.0025678587,
0.01192705,
-0.014609146,
-0.005586045,
-0.01970844,
0.023973305,
0.0016142245,
0.0051456513,
-0.027125595,
-0.01793362,
0.019761419,
-0.024185224,
-0.0059999484,
0.0005782235,
-0.021562729,
0.00038969037,
-0.03252952,
0.025721634,
0.0068674907,
-0.023032915,
0.017695213,
0.0048443293,
-0.00041307593,
-0.014039614,
0.011450233,
-0.026529573,
-0.014383983,
-0.033589117,
-0.003834404,
-0.0046622115,
0.016013108,
0.009569454,
0.009735016,
0.03430434,
-0.014357492,
-0.021668687,
-0.015377351,
0.02140379,
0.013562798,
-0.008569463,
-0.015032983,
-0.0024056085,
0.004526451,
0.02150975,
-0.0060827294,
-0.02641037,
0.027125595,
0.024675285,
0.006397296,
-0.023668671,
0.007145634,
0.051443268,
-0.0021721667,
-0.012748235,
0.017589252,
-0.003917185,
0.011264804,
-0.013211807,
0.026423614,
-0.0054933303,
-0.013311144,
-0.00085926417,
-0.0049502887,
0.053456493,
-0.0047913496,
-0.0038542715,
0.014900534,
-0.0037681796,
-0.00783437,
-0.12736315,
-0.037801,
0.002471833,
0.013211807,
-0.009218464,
0.038701653,
0.0042714863,
0.0049933344,
-0.022834241,
0.025297796,
-0.015324372,
0.007244971,
0.005705249,
-0.009529719,
0.016039597,
-0.004016522,
0.016927008,
-0.014648881,
-0.028476577,
0.03954933,
0.011682019,
-0.0049536,
0.027575921,
-0.026224941,
-0.0052416767,
0.018185275,
-0.028503066,
0.0037483121,
0.020900482,
-0.004562875,
0.019231623,
-0.024436876,
-0.010238322,
-0.007748278,
-0.018185275,
-0.026940165,
0.0008414663,
-0.005903923,
0.028556047,
0.013079358,
-0.0032996405,
0.01561576,
0.016436946,
-0.011986652,
0.0149932485,
-0.014079349,
-0.011761488,
-0.000743785,
-0.002730109,
-0.031549398,
-0.01709919,
-0.022489874,
-0.014158819,
-0.011754866,
0.024979917,
-0.020979952,
0.020158768,
0.01556278,
-0.016648864,
0.0077549005,
-0.00091555505,
-0.0013725047,
-0.010013159,
0.013013133,
0.013629022,
-0.016953496,
-0.02127134,
0.00039010425,
0.019642215,
-0.027231554,
0.005864188,
0.007622451,
-0.023814365,
-0.011231692,
-0.024754755,
0.019973338,
-0.040052637,
-0.0073111956,
-0.00035844062,
-0.021867363,
-0.008516483,
-0.029615639,
0.017827662,
-0.0132449195,
0.020900482,
0.011430365,
-0.0119469175,
-0.01109262,
0.00393043,
-0.014092594,
-0.02458257,
0.04111223,
0.004033078,
-0.02051638,
-0.013655512,
0.025509715,
0.00058484596,
-0.006642327,
0.024132242,
0.028158698,
-0.014357492,
-0.010211833,
-0.0594432,
-0.002673818,
0.0026887187,
-0.007741655,
0.017840907,
-0.01819852,
0.014198554,
-0.0059833922,
0.005211876,
0.0045132064,
-0.0027698437,
0.026860697,
0.004221818,
-0.023350792,
-0.022781262,
-0.009927067,
0.012582674,
0.011576059,
-0.00086009194,
0.019390563,
0.003731756,
-0.0002485492,
0.014489942,
-0.014291268,
-0.009940312,
0.0004329433,
-0.0027698437,
0.0077681453,
-0.023734896,
-0.00068087166,
-0.01182109,
-0.025642164,
-0.00511585,
0.0071655014,
0.010271435,
-0.023920324,
0.004407247,
0.0058277645,
0.003031431,
0.032317605,
-0.006264847,
-0.031072581,
0.005188697,
0.018582622,
0.017748192,
0.011264804,
-0.012264796,
-0.00148757,
0.0121919485,
-0.0121919485,
0.03308581,
0.0017268064,
-0.0070330524,
-0.014966759,
-0.0054403506,
0.0066191484,
-0.000288077,
-0.004579431,
0.00912575,
-0.0263309,
-0.0013741604,
0.008602575,
0.010794609,
-0.0031506352,
0.009244953,
-0.017774682,
-0.01978791,
-0.007549604,
0.017668722,
-0.020821013,
-0.021721669,
-0.0015629005,
0.010622425,
0.018357458,
-0.006639016,
-0.013529685,
-0.012423734,
0.00452314,
-0.010927059,
0.013033001,
0.016132312,
-0.021019688,
0.005291345,
0.026450103,
0.041562557,
0.00086837,
-0.01467537,
-0.006268158,
0.0022284577,
0.026238184,
0.00037002994,
0.015827678,
0.015496556,
0.017642232,
-0.015470066,
0.0076754307,
-0.0046887016,
0.012609163,
0.00414566,
0.014132329,
0.010595935,
-0.001895679,
0.017893886,
-0.003675465,
-0.01731111,
0.018556133,
-0.0095032295,
-0.03785398,
-0.003327786,
0.009893955,
0.020450156,
-0.009496607,
-0.022820996,
0.0018890566,
-0.01195354,
0.032185156,
0.012284663,
-0.019615725,
-0.017297864,
0.040635414,
0.01715217,
0.010655537,
-0.005744984,
0.005129095,
0.007748278,
0.02312563,
0.03557585,
-0.015774699,
-0.005529754,
0.0033906994,
0.00020012245,
-0.008059533,
-0.038489737,
-0.010695272,
-0.027152084,
0.0051489626,
-0.0015960127,
0.0149932485,
-0.0062482907,
0.08598602,
0.010059516,
-0.013397236,
0.039204963,
-0.016847538,
0.060237892,
0.022662057,
0.02964213,
-0.02132432,
0.009311179,
0.0017847529,
-0.04442346,
0.015059473,
-0.050569102,
-0.008794626,
0.010483353,
-0.009688659,
0.015787944,
0.012655521,
-0.030622253,
0.005774785,
-0.011503212,
0.013185318,
0.008496616,
-0.036608957,
0.00823834,
0.035787772,
0.009026413,
0.013529685,
0.0031473238,
0.01788064,
-0.007450267,
-0.038781125,
0.008172115,
-0.008112513,
-0.0016821048,
-0.010854212,
-0.020781279,
0.038436756,
0.015999863,
0.012953531,
-0.022609077,
0.0021804448,
-0.021840872,
0.017390579,
0.0012566118,
-0.023575956,
0.0127747245,
0.0005753262
] |
Oncogenic mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) occur in several types of cancer, but the metabolic consequences of these genetic changes are not fully understood. In this study, we performed (13)C metabolic flux analysis on a panel of isogenic cell lines containing heterozygous IDH1/2 mutations. We observed that under hypoxic conditions, IDH1-mutant cells exhibited increased oxidative tricarboxylic acid metabolism along with decreased reductive glutamine metabolism, but not IDH2-mutant cells. However, selective inhibition of
|
[
-0.009911038,
-0.0107096825,
0.011757084,
-0.032993153,
-0.026734928,
0.016981,
-0.01885323,
0.0034596988,
-0.008660703,
0.0069848597,
0.029720023,
0.015344434,
0.023749834,
0.006762287,
-0.023252318,
-0.00013777832,
0.038282532,
-0.00024466647,
0.0053646606,
0.014912382,
-0.03948704,
0.0134329265,
-0.0016062887,
-0.010087787,
0.007456191,
0.03521888,
0.0034498794,
-0.03147442,
0.0036102626,
-0.0139959045,
0.018669935,
-0.0059440047,
-0.0074038208,
-0.007043776,
-0.007115785,
-0.0042092456,
0.0044383644,
-0.010519841,
0.00060962053,
-0.025124548,
0.015828857,
0.012176044,
-0.023226133,
-0.0072205253,
0.0016627501,
0.029641468,
0.002386112,
-0.01316453,
-0.0054661273,
0.026054116,
0.0045823823,
0.030531758,
0.0038524743,
0.012483719,
-0.003202758,
-0.0030505573,
0.012110582,
0.025687527,
-0.016548946,
-0.00024712132,
0.0122545995,
-0.0211837,
-0.025163826,
0.022702431,
-0.0059178197,
0.005734524,
0.033255003,
0.0101205185,
0.013720962,
-0.0071812477,
0.025320936,
0.008431584,
-0.019232914,
-0.016090708,
0.020267222,
-0.022767894,
-0.04056063,
-0.022165637,
0.013786425,
0.008228649,
0.028960656,
-0.02778233,
-0.0055905064,
0.025425676,
0.018355714,
0.006353146,
-0.014532698,
0.020162482,
0.012981234,
-0.0027936166,
0.010035417,
0.013616222,
0.023880757,
0.0020866205,
-0.018237881,
0.0068015647,
-0.0065724454,
0.020005371,
-0.0034367868,
-0.02181214,
-0.012719384,
0.011940379,
-0.0063400534,
-0.012090943,
-0.020712368,
0.00007645828,
0.0027379734,
0.0127717545,
0.010231805,
-0.005727978,
0.004117598,
0.032338526,
0.004523466,
-0.040586814,
0.0131383445,
-0.0111024575,
0.035035588,
0.019586412,
-0.01407446,
-0.014061367,
0.011685075,
0.01391735,
0.00055684126,
-0.019049618,
0.015305157,
-0.0035153418,
-0.015501545,
-0.0151742315,
0.012123674,
-0.009033839,
0.014401773,
-0.0073710894,
0.013537667,
-0.007992984,
-0.016365651,
0.013904258,
-0.0069979522,
-0.016404929,
-0.002250277,
-0.036528133,
0.0012920682,
0.015017121,
-0.0046183867,
0.0026037751,
-0.024797235,
0.012725931,
0.002464667,
0.017177388,
0.0016758427,
-0.009701558,
-0.008032261,
-0.013616222,
0.033124078,
-0.016653687,
0.013210353,
0.03584732,
0.003390963,
0.006582265,
-0.026158856,
-0.0022028165,
-0.0021422638,
-0.019350747,
-0.020856386,
0.0031127469,
0.011213744,
0.024954345,
0.0126735605,
-0.009649188,
-0.0074169133,
-0.012856856,
-0.003692091,
0.036685243,
-0.034668997,
0.026564725,
-0.0161038,
0.018159326,
-0.0020309773,
0.02746811,
-0.02321304,
-0.0119600175,
-0.0034236943,
0.037366055,
0.018303344,
-0.007115785,
-0.006853935,
0.0006812202,
0.0043761753,
0.014375588,
0.006182943,
-0.017858198,
-0.012824125,
0.02587082,
0.0037117298,
-0.0054104845,
-0.6305358,
-0.038596753,
-0.007822781,
-0.035009403,
0.0010989534,
0.03157916,
0.019206729,
0.0066673663,
-0.006104388,
0.010068148,
0.0059374585,
0.044802606,
0.008064993,
-0.024522291,
0.0007184521,
-0.040324964,
-0.011914194,
-0.014244663,
-0.003845928,
-0.0064447937,
-0.007953706,
-0.0031487513,
-0.0161038,
-0.016038338,
-0.0034826107,
0.026355244,
0.029772393,
-0.012876495,
0.013511482,
0.03322882,
-0.008745804,
0.017897476,
-0.004575836,
-0.025399491,
0.045823824,
-0.0024483015,
0.019586412,
0.01874849,
0.007266349,
0.030505573,
-0.0016079253,
-0.0034924299,
0.026198134,
-0.004654391,
-0.022047805,
0.019206729,
-0.00088456343,
0.014768364,
0.023134485,
-0.006781926,
-0.010474017,
0.0026397796,
-0.02746811,
-0.006516802,
0.008045354,
-0.013603129,
0.021785954,
-0.0033336831,
0.024941253,
0.013210353,
0.00172003,
0.035454545,
-0.03417148,
0.00087392575,
0.012974688,
0.0155801,
0.0054726736,
0.008955284,
-0.013668592,
-0.0045922017,
0.017308313,
0.017059555,
-0.013190715,
0.016444206,
0.023291595,
0.023632001,
0.010402008,
0.02123607,
-0.0016578404,
0.021209884,
0.011953471,
-0.0023288322,
-0.03948704,
0.001682389,
0.02051598,
-0.0056232377,
-0.008608333,
0.012856856,
-0.015278972,
-0.010559118,
0.03584732,
-0.012588459,
-0.009989593,
-0.05017054,
-0.011207198,
0.014270848,
-0.017399961,
0.024011683,
0.01729522,
-0.021249162,
-0.0250329,
-0.011678529,
0.009799752,
0.0063433265,
0.016404929,
0.012667014,
-0.04503827,
-0.013799517,
0.037994497,
-0.0012192411,
-0.0062222206,
-0.013747147,
-0.0101205185,
0.0068997587,
-0.008091178,
-0.01165889,
0.023736741,
0.005253374,
-0.014676716,
-0.041948438,
0.005227189,
0.014270848,
-0.02009702,
-0.017557072,
0.012843763,
0.0018149507,
0.0050177085,
-0.016182356,
0.00010606988,
-0.008686888,
0.0075609307,
0.008968377,
0.014310125,
-0.015108769,
0.00789479,
-0.01155415,
0.011881463,
-0.008241742,
-0.0018558649,
-0.025635157,
-0.029196322,
-0.019390024,
0.007763865,
0.00833339,
-0.019717336,
-0.0014655441,
-0.036999464,
-0.008876729,
0.008601787,
0.007017591,
-0.011717807,
0.0039048444,
-0.0311602,
0.029667653,
0.012627737,
-0.025255473,
0.013603129,
-0.0042812545,
0.0049947966,
0.0024433918,
0.0066542737,
0.016954815,
0.00799953,
0.013393649,
-0.020136297,
-0.008241742,
-0.008706527,
-0.008948738,
0.00009067594,
-0.013485297,
-0.01787129,
-0.025019808,
-0.008117363,
-0.0066477275,
0.009904492,
0.009976501,
-0.011632705,
0.0032796764,
-0.014427958,
0.0072467104,
0.0072467104,
-0.008267927,
-0.0038557474,
-0.0180284,
0.015462267,
0.022113267,
0.020804016,
0.004824594,
0.00859524,
0.05011817,
-0.0081828255,
0.032678932,
-0.0029818215,
0.008968377,
0.015069491,
0.008483954,
0.01080133,
-0.016444206,
-0.019638782,
0.02316067,
0.023906942,
-0.023920035,
0.011541057,
-0.0037804653,
0.03241708,
-0.016483484,
-0.00026144128,
-0.0026479624,
0.0024712132,
-0.009132033,
0.0054923124,
0.0044940077,
-0.0030538305,
0.015252787,
-0.017648717,
0.0025955923,
-0.023854572,
0.0054759467,
-0.008523231,
-0.021772861,
0.0005515224,
0.012856856,
0.015056399,
-0.014964752,
0.022087082,
-0.011174466,
-0.010820969,
0.0051879114,
0.024784142,
0.0056887004,
0.0044907345,
0.012405164,
-0.009289144,
-0.003976853,
0.0066771857,
0.037313685,
-0.002009702,
-0.0061469385,
0.05561703,
-0.0049129683,
-0.006886666,
-0.0018525918,
-0.015396805,
0.00037640997,
0.008418491,
-0.0042059724,
0.053260375,
-0.004405633,
-0.02762522,
0.007285988,
-0.013446019,
0.022401303,
0.003466245,
-0.01832953,
0.0082810195,
-0.020031556,
0.0043565365,
0.034826107,
0.043467168,
0.013747147,
-0.0012617917,
-0.013243085,
0.0048802374,
-0.01599906,
-0.027075334,
0.010284175,
0.0040554083,
0.007515107,
0.018813953,
0.017360684,
-0.041869882,
-0.0108078765,
-0.018787768,
-0.0444622,
0.01391735,
0.0070830537,
-0.012817578,
0.005436669,
0.03770646,
0.02389385,
0.016221633,
-0.020070834,
0.036737613,
0.01176363,
-0.0071485164,
-0.010650766,
-0.020385055,
0.0006971767,
0.005927639,
0.021262255,
0.009276051,
0.007973345,
-0.004497281,
0.009708105,
-0.00424525,
-0.029405802,
0.0042583426,
-0.02746811,
0.028070364,
-0.012090943,
-0.01832953,
0.009773567,
-0.018290251,
0.0142184775,
0.050091986,
0.022204915,
0.012274238,
-0.002212636,
-0.011109004,
-0.03333356,
0.0019033252,
-0.0038819325,
-0.0051453607,
-0.013203807,
-0.010631127,
-0.016444206,
-0.006755741,
0.0064775245,
0.008215557,
0.001870594,
-0.00623204,
-0.01962569,
-0.009046932,
-0.023933128,
0.0121564055,
0.02597556,
-0.029955689,
0.011410132,
0.022204915,
0.019429302,
0.006107661,
-0.030688869,
0.019507857,
-0.024692494,
-0.00006321233,
-0.005502132,
0.016758427,
-0.015213509,
0.003462972,
0.02191688,
0.0034466062,
-0.01412683,
-0.026289782,
0.013524574,
-0.014873104,
-0.020908756,
0.007135424,
0.039565597,
0.030086612,
0.0027265174,
0.023487983,
0.030453203,
0.008830905,
-0.018840138,
-0.0017020277,
0.002754339,
-0.0056952466,
0.017557072,
0.0019949728,
-0.026721835,
0.017007185,
-0.0026512356,
0.029667653,
0.007292534,
0.0072008865,
-0.0068408423,
0.013720962,
0.020607628,
0.0069390363,
0.011095911,
-0.026119579,
0.01207785,
0.0007900518,
-0.029877134,
0.01631328,
-0.013720962,
-0.026132671,
-0.022466766,
0.008699981,
0.0011799635,
-0.0084774075,
-0.021118237,
-0.0016791158,
0.011881463,
-0.0016954815,
-0.008294112,
0.014637439,
0.017203573,
0.0039343024,
0.012071304,
-0.0036069895,
-0.023239225,
-0.03194575,
-0.011757084,
0.011599974,
-0.0115934275,
-0.020123204,
0.0053122905,
0.006038925,
0.029667653,
-0.0016987546,
-0.020934941,
0.004363083,
0.018447362,
-0.037156574,
-0.007266349,
-0.009537902,
-0.027049148,
-0.005030801,
-0.010716229,
-0.008798174,
-0.021877602,
-0.009675373,
0.02680039,
0.0033582316,
-0.023645094,
-0.020489795,
0.0063858773,
0.0045071,
0.025582787,
0.005508678,
-0.001589923,
-0.006058564,
0.0019475125,
0.012981234,
-0.023710556,
-0.023566538,
-0.03375252,
-0.0050929906,
-0.030453203,
-0.0024597573,
-0.0076329396,
0.016378744,
-0.005983282,
0.024600847,
0.010382369,
0.00344006,
-0.004346717,
0.024273533,
0.02389385,
-0.02144555,
0.006209128,
-0.006182943,
0.0038295623,
0.010762053,
-0.008569055,
0.035873506,
-0.003518615,
-0.012228414,
0.010061602,
-0.0034727913,
-0.03802068,
-0.016994093,
0.007115785,
-0.005348295,
0.03883242,
0.008078085,
-0.0138257025,
-0.019023433,
0.00649389,
0.003927756,
-0.0011030448,
0.004677303,
-0.0043794485,
-0.02289882,
0.02186451,
-0.0026856035,
-0.018512825,
-0.009380791,
-0.030479388,
-0.018394992,
0.019913724,
0.011992749,
0.002325559,
-0.0093349675,
-0.003518615,
-0.025962468,
-0.019874446,
-0.017007185,
-0.026407614,
0.007953706,
-0.005079898,
0.04482879,
0.030557944,
0.026158856,
0.002574317,
0.03697328,
0.038177792,
0.014676716,
-0.0036528134,
0.009943769,
0.00096311857,
-0.029981872,
0.006562626,
-0.013013965,
0.0026365065,
0.02326541,
-0.009636096,
0.008719619,
0.027127704,
-0.01370787,
-0.020659998,
0.004477642,
-0.028227475,
-0.021825232,
0.022885727,
-0.025281658,
-0.018421177,
-0.046504635,
-0.014008997,
0.038570568,
-0.0015792854,
-0.00009931905,
0.0038557474,
0.0231083,
-0.0083792135,
0.025582787,
0.0004827867,
-0.0075543844,
0.005423577,
-0.023632001,
0.010212166,
-0.012280785,
0.008752351,
-0.0072074328,
0.018368807,
0.005034074,
-0.0316839,
0.03163153,
0.015108769,
-0.018237881,
0.0076984023,
-0.0023828389,
-0.01979589,
-0.008071539,
-0.029327247,
-0.006736102,
-0.016679872,
0.0069193975,
0.015030214,
-0.02862025,
0.0010793147,
-0.0125753665,
-0.008981469,
0.03105546,
-0.008287566,
0.026577817,
-0.017282128,
0.041162886,
0.0023206493,
-0.008006076,
-0.0211837,
-0.013851888,
0.0020195213,
-0.0076787635,
0.044017054,
0.0134329265,
-0.0060421983,
-0.01724285,
-0.0021193519,
-0.016706057,
-0.017151203,
-0.009852122,
0.019154359,
-0.0040619546,
0.013563852,
-0.017949846,
-0.014689809,
-0.016339466,
0.011874917,
-0.0015449175,
0.019442394,
-0.014454143,
-0.008752351,
-0.027546665,
0.033464484,
0.01381261,
0.01004851,
0.016967908,
0.0066968245,
-0.01376024,
-0.043702833,
-0.023343965,
0.016653687,
-0.008863636,
0.019494765,
-0.02326541,
0.009616457,
-0.0019769706,
-0.006254952,
-0.019128174,
-0.0077835037,
-0.01682389,
0.036135357,
-0.009845575,
-0.0027788875,
0.016745334,
-0.0012814305,
0.019560227,
-0.0025923192,
0.0026299602,
-0.026970593,
-0.0372875,
0.019586412,
0.034407146,
0.0044940077,
0.009649188,
0.0049882503,
-0.02638143,
-0.015017121,
-0.032783672,
-0.040482074,
0.022636969,
-0.04310058,
-0.010356184,
-0.008248288,
0.02420807,
0.005420304,
0.007835873,
-0.0030161894,
0.00063375983,
0.035454545,
-0.0094331615,
0.021092052,
0.026446892,
0.008457769,
-0.008641064,
0.0086737955,
-0.0038295623,
-0.020555258,
0.0073449044,
-0.002991641,
-0.032888412,
-0.012326608,
0.018093864,
-0.0007057687,
0.007285988,
-0.0042092456,
0.01936384,
0.0078031425,
0.01671915,
-0.017426146,
-0.034040555,
0.032940783,
-0.035611656,
0.021772861,
0.011259568,
-0.00058834517,
-0.008667249,
-0.010035417,
-0.00547922,
-0.008444676,
0.0044449107,
-0.011390493,
-0.02233584,
-0.008006076,
0.0012216959,
0.011135189,
0.0071485164,
-0.0069652214,
-0.023330873,
0.00833339,
0.00784242,
0.006467705,
-0.017439239,
0.0031896655,
-0.00079700723,
0.0031683901,
-0.026080301,
-0.0211837,
-0.0016742061,
-0.017635625,
-0.03919901,
-0.013105613,
-0.010938801,
0.024286626,
0.01974352,
-0.021196792,
-0.023252318,
-0.01573721,
-0.060854036,
-0.010369277,
0.002423753,
0.009177857,
0.022571506,
0.030348463,
-0.025478046,
0.007357997,
-0.011344669,
0.019128174,
-0.014008997,
-0.013085974,
0.01832953,
0.026211226,
0.02062072,
-0.0019736975,
-0.017255943,
-0.010755506,
0.012680107,
-0.0065495335,
0.0012012388,
0.011816001,
-0.011076272,
0.019167451,
0.0078882435,
0.0106114885,
0.009073117,
0.0011586881,
-0.015095676,
-0.005482493,
-0.005502132,
0.024587754,
0.017753458,
0.0053613875,
-0.0039179367,
0.0040914128,
0.022244193,
-0.00890946,
-0.019442394,
-0.026289782,
0.0043827216,
-0.017491609,
-0.010598396,
0.012437895,
0.011979656,
0.012045119,
0.018120049,
-0.012608098,
0.010094333,
-0.0040914128,
-0.022650061,
-0.010441286,
0.014820734,
-0.0022568232,
-0.014270848,
-0.0027821606,
-0.0075805695,
-0.028122734,
-0.019232914,
-0.0020146116,
-0.009249866,
-0.021249162,
0.015449175,
-0.022754801,
-0.036423393,
-0.015357527,
0.0113970395,
-0.017858198,
-0.0018542283,
0.0013272543,
0.0068670274,
-0.021956157,
-0.011698168,
-0.020371962,
0.0024859423,
0.0024581207,
0.0010776782,
-0.028489325,
-0.015265879,
0.027939439,
0.18507588,
0.010912616,
0.0039441218,
0.0316839,
-0.008798174,
-0.013341279,
0.0071288776,
0.00084692246,
0.0048605986,
0.015213509,
0.0086737955,
-0.0019376931,
-0.004369629,
-0.007456191,
0.030348463,
0.013256177,
-0.030531758,
0.009374245,
-0.027860885,
-0.013851888,
0.0037248223,
-0.013485297,
0.0071026925,
-0.006454613,
0.014100645,
0.0018935058,
-0.01337401,
-0.0070044985,
0.02851551,
-0.00019260326,
-0.027206259,
0.0105132945,
-0.012889587,
-0.0043794485,
-0.005397392,
0.0061011147,
-0.00397358,
-0.01703337,
-0.017858198,
0.0077049485,
0.00693249,
0.015593193,
-0.018630657,
-0.009839029,
-0.038806234,
0.010251444,
0.0010334909,
0.00040341332,
0.011259568,
-0.021039682,
-0.054622,
0.005534863,
0.009891399,
0.010997717,
0.015645562,
-0.010323453,
0.032783672,
-0.011757084,
-0.011979656,
0.008758897,
-0.014663624,
0.011292299,
-0.025320936,
0.009714651,
-0.010244898,
0.03152679,
-0.038413458,
-0.019167451,
-0.00061084796,
0.002924542,
0.0031683901,
-0.035349805,
-0.017753458,
0.010087787,
0.0013100704,
-0.0074758297,
0.028489325,
0.02107896,
0.008726166,
0.017727273,
0.016850075,
0.0027117885,
-0.01692863,
0.011455956,
-0.03333356,
-0.02830603,
0.017360684,
0.023029745,
-0.021314625,
-0.0031585707,
0.017596347,
-0.008994562,
-0.0025579513,
-0.0035055224,
-0.00397358,
0.012444441,
-0.007187794,
-0.019088896,
0.0014745452,
-0.03432859,
-0.026892038,
0.076303214,
-0.0017920388,
0.0017773097,
-0.011835639,
0.012693199,
-0.010382369,
-0.0027117885,
0.0027117885,
0.008372667,
0.0024712132,
-0.0334383,
0.00041159612,
-0.000004238448,
-0.0026790572,
0.022165637,
-0.0061894893,
-0.037523165,
0.011914194,
-0.013053243,
0.016889352,
-0.026302874,
-0.0002160266,
0.023448706,
-0.026813483,
-0.0010776782,
-0.032600377,
0.0046314793,
-0.013459112,
-0.03189338,
-0.001491729,
0.0025448587,
0.0047100345,
0.012529543,
0.0037575534,
0.012667014,
0.014846919,
-0.023592724,
-0.00896183,
0.0121564055,
-0.0065266215,
0.029720023,
0.006487344,
0.017727273,
0.0018133142,
-0.03194575,
0.022741709,
-0.016418021,
-0.006104388,
-0.019547135,
-0.0047394927,
-0.020843294,
-0.0047133076,
0.011560696,
0.028803546,
-0.010827515,
-0.0008227831,
-0.044331275,
0.0033549585,
0.02072546,
-0.020123204,
0.035245065,
-0.002273189,
-0.012143313,
0.0010735868,
-0.0024384821,
-0.16339466,
-0.0041045053,
0.021681216,
-0.014729086,
0.03328119,
0.020489795,
0.024312811,
-0.017111925,
0.01144941,
0.0087719895,
0.022375118,
-0.021511013,
-0.04825903,
0.00024343906,
-0.00155801,
0.032888412,
0.0069979522,
0.036554318,
0.013243085,
-0.005073352,
0.028594065,
-0.013747147,
0.02487579,
-0.006182943,
-0.001552282,
0.020293407,
-0.0010351274,
0.0062189475,
-0.01578958,
0.0067230095,
-0.009125487,
0.004530012,
0.03079361,
-0.010546026,
0.023618909,
-0.009164765,
-0.02056835,
0.023566538,
-0.0044841883,
-0.022859542,
0.018722305,
0.014558883,
0.015331342,
-0.012326608,
-0.014715994,
0.025687527,
0.0161038,
0.0030914715,
0.017897476,
0.010506748,
0.0360568,
0.002980185,
0.008758897,
0.021366995,
0.029405802,
-0.0024744864,
0.006925944,
0.00968192,
-0.025936283,
-0.023304688,
-0.014990936,
-0.02746811,
0.030060427,
-0.008601787,
0.0030538305,
-0.02856788,
0.00022195914,
-0.0125491815,
-0.034957033,
0.0094528,
-0.01832953,
-0.0052402816,
0.009367699,
-0.00022032257,
0.019337654,
-0.0058949078,
-0.0071550626,
0.0034924299,
-0.0096557345,
-0.0012437894,
-0.02477105,
0.009033839,
-0.03686854,
-0.017648717,
-0.011141735,
0.005829445,
0.017465424,
0.007515107,
-0.009393884,
0.0021128056,
0.023906942,
-0.018761583,
0.006182943,
-0.02767759,
0.005230462,
0.015017121,
0.008549416,
0.00789479,
0.0148076415,
0.004500554,
-0.0020326138,
-0.016745334,
-0.036475763,
0.009151672,
0.040901035,
0.009269505,
-0.019442394,
-0.0014786366,
0.050798982,
0.01004851,
-0.009727743,
0.010487109,
0.0061469385,
0.022780987,
-0.0072532566,
0.024273533,
-0.0037640997,
-0.0032453085,
-0.01626091,
-0.008686888,
0.073108636,
0.008830905,
-0.00784242,
-0.00628441,
-0.0118880095,
-0.03681617,
-0.12767826,
-0.03241708,
0.0063858773,
-0.0044612763,
0.015724117,
0.021877602,
0.0010277629,
-0.00263487,
-0.0070896,
0.026054116,
-0.024836512,
-0.0053908457,
0.004742766,
0.015095676,
0.015108769,
-0.011390493,
0.016496576,
0.00688012,
-0.011894555,
0.037837386,
-0.026211226,
0.017596347,
-0.031291123,
-0.014454143,
-0.012182591,
-0.012018934,
-0.03359541,
0.026761113,
-0.0011177739,
0.008732712,
0.022244193,
0.0046642106,
0.014977844,
0.004984977,
-0.013027058,
0.009969954,
0.030322278,
-0.038308717,
0.05291997,
-0.01626091,
-0.012182591,
0.02062072,
0.025504231,
0.031657714,
0.021851417,
-0.018735398,
0.00054824934,
0.006808111,
0.010997717,
-0.039303746,
-0.033255003,
0.0108537,
-0.023579631,
-0.020699276,
0.015436082,
-0.038439643,
0.013799517,
0.020319592,
-0.030269908,
0.0070503224,
-0.0032305794,
-0.01760944,
-0.01262119,
0.001450815,
0.018093864,
-0.03194575,
-0.020044649,
-0.029720023,
0.031291123,
-0.035009403,
-0.0068735736,
0.007285988,
-0.024338996,
-0.016234726,
-0.018630657,
0.0011472321,
0.0024548478,
0.00016754336,
-0.0007049504,
-0.006153485,
-0.017583255,
-0.010703136,
0.011796362,
-0.024640124,
0.019285284,
-0.003390963,
0.007639486,
-0.0049096956,
0.022257285,
-0.017255943,
-0.0136293145,
0.04118907,
0.006709917,
-0.019036526,
-0.0087719895,
0.032783672,
0.014624346,
0.0007147698,
0.02077783,
0.02788707,
-0.03574258,
-0.02570062,
-0.05535518,
0.022807172,
0.004556197,
0.0005093809,
0.017426146,
-0.013904258,
0.0022895546,
-0.009308782,
-0.00049137865,
0.025530417,
-0.0018640477,
0.0035284343,
-0.027389554,
-0.013878073,
0.00061166624,
-0.01573721,
0.016339466,
0.007240164,
0.014820734,
0.01776655,
0.0069128512,
-0.011482141,
0.0007839147,
0.000999123,
-0.007292534,
-0.009485532,
-0.021432457,
0.023920035,
0.0046609375,
-0.03563784,
0.01760944,
-0.027389554,
0.0003226079,
-0.005708339,
-0.011043541,
-0.014663624,
-0.009943769,
0.012149859,
0.005511951,
0.03697328,
-0.031029275,
-0.0148076415,
0.021196792,
0.026041023,
0.00089765596,
-0.00075895706,
-0.035821136,
0.009629549,
-0.0018836864,
0.00515518,
0.026708743,
0.0019802437,
-0.015344434,
-0.028436955,
-0.013616222,
-0.026119579,
0.0047656777,
0.013472204,
-0.019586412,
-0.0146112535,
0.015331342,
-0.012562274,
0.033962,
-0.0002299374,
0.006634635,
-0.0067950184,
-0.021144422,
-0.011390493,
0.0063629653,
-0.03157916,
-0.026669465,
0.0010932256,
0.0030391014,
0.017360684,
0.001810041,
-0.0059931013,
-0.011907647,
0.01885323,
0.019075803,
0.00973429,
0.027206259,
-0.00553159,
-0.024142608,
0.018866323,
0.026106486,
-0.008935645,
0.0017691269,
0.037627906,
0.022728616,
-0.011331577,
0.0042845276,
-0.004598748,
0.009328421,
0.01127266,
0.010271083,
0.011364308,
-0.005106083,
-0.0013198898,
0.007973345,
0.061430108,
-0.0014835463,
-0.0044645495,
0.008346482,
-0.01584195,
-0.0025186737,
0.015134954,
-0.02014939,
-0.04488116,
-0.016850075,
0.009269505,
0.004117598,
0.026237411,
-0.02014939,
0.010336545,
-0.016326373,
-0.008339936,
-0.014270848,
0.015409897,
-0.008038808,
0.023199948,
0.011279207,
0.0041896068,
0.007547838,
0.0043303515,
0.03390963,
0.007875151,
0.03443333,
-0.013472204,
0.024064053,
-0.011809454,
0.026211226,
0.008267927,
-0.039565597,
-0.022820264,
-0.002186451,
-0.022034712,
0.011082819,
-0.009118941,
0.0049686115,
0.083582655,
0.021668123,
-0.015881227,
-0.0125753665,
-0.02233584,
0.013734055,
0.026892038,
0.0105132945,
0.003345139,
-0.042550694,
0.007541292,
-0.015252787,
0.029746208,
-0.04451457,
-0.03739224,
0.011822547,
-0.00026225956,
0.0067950184,
0.026473077,
-0.017399961,
0.008130455,
0.006212401,
-0.0025759535,
0.020686183,
-0.020542165,
-0.0072794417,
0.033831075,
-0.0095575405,
-0.019560227,
-0.028882101,
0.0065233484,
-0.012123674,
-0.026944408,
0.0065233484,
0.032836042,
-0.015108769,
0.0028803546,
-0.0128699485,
0.019311469,
0.019966094,
0.0025677707,
-0.010212166,
-0.023671279,
-0.023985498,
-0.01589432,
-0.011567242,
0.004215792,
0.0022682792,
-0.008137002
] |
The aim of this study is to determine the prognostic value of tumor markers, as squamous cell carcinoma antigen (SCCAg) and cytokeratin-19 fragment (CYFRA 21.1) and interleukin 6 (IL-6), vascular endothelial growth factor (VEGF), soluble tumor necrosis factor receptor I (sTNF RI), and sTNF RII in patients with squamous cell carcinoma of the cervix. The subjects of analysis were 138 patients with stage I-IVA according to the International Federation of Gynecology and Obstetrics (FIGO) classification. The collected
|
[
-0.021744432,
-0.0013697867,
0.009713484,
-0.017546512,
-0.00999158,
-0.009283097,
-0.037847493,
0.0006124726,
-0.040972758,
-0.000083232124,
0.029213287,
0.0011430063,
0.0034298464,
0.015401202,
-0.01938724,
-0.0057373783,
0.02428702,
-0.008508403,
-0.021333909,
-0.00249955,
-0.013904783,
0.028921949,
-0.01544093,
0.0055288062,
-0.023492461,
0.03996632,
-0.008501781,
-0.046878982,
0.0052705747,
-0.003338803,
-0.0028306164,
-0.00012994351,
-0.010455072,
-0.000011542056,
0.0063697146,
0.0026154234,
0.006601461,
-0.00056943396,
0.02158552,
0.0033487352,
0.012752672,
0.0038834072,
-0.00015291122,
-0.022459535,
-0.016394401,
-0.0062803268,
0.0040092124,
-0.020473137,
-0.008481917,
0.014646371,
0.0199964,
0.00023629854,
-0.02643233,
-0.009859153,
0.003933067,
0.0031467848,
0.00944201,
0.027915506,
-0.0056082625,
-0.02143985,
-0.012156753,
0.010878837,
-0.02992839,
0.004283997,
-0.0024912735,
-0.012474576,
-0.015401202,
0.017586239,
-0.011567455,
0.0030706394,
0.029769478,
0.04423045,
-0.016328188,
-0.020367196,
0.022711145,
-0.009832668,
-0.027015006,
-0.012858613,
-0.00020143313,
0.011878657,
0.016977077,
-0.027809566,
-0.0049659936,
0.0069590127,
0.009852531,
0.021135269,
-0.016672496,
-0.00031678902,
0.0010031308,
0.0029448343,
0.028577639,
0.023068696,
-0.0048236353,
0.020777717,
-0.015520386,
0.013997481,
-0.005671165,
0.027438771,
0.014659613,
-0.033477418,
0.0075747957,
-0.0018953542,
0.0086408295,
-0.016248731,
-0.03082889,
-0.015123107,
-0.0021701392,
0.0070914393,
0.01834107,
-0.0071841376,
-0.014222606,
0.04168786,
-0.0020046062,
-0.004187988,
0.028312786,
-0.014235849,
0.026617726,
0.016116304,
-0.02578344,
-0.006680917,
0.006770305,
-0.0011446616,
0.032762315,
-0.027173918,
0.03572867,
0.0028935191,
-0.0026021807,
-0.0069590127,
-0.021810645,
-0.008680557,
0.0016453993,
0.0018920436,
0.026140992,
-0.003717874,
0.009726726,
-0.020751232,
-0.014845011,
-0.014553673,
-0.012646731,
-0.025717227,
-0.017453812,
0.036258377,
-0.013368456,
-0.0021717947,
-0.03326554,
-0.014672857,
0.011607183,
0.0057042716,
0.017030047,
-0.0049858578,
-0.010700061,
-0.034271978,
0.01808946,
-0.0053235455,
0.004168124,
0.011680017,
0.006740509,
0.034324948,
-0.020949872,
0.003989348,
-0.02788902,
-0.00043162762,
0.022923028,
0.021333909,
0.0038635433,
0.010223326,
0.0024929289,
-0.00479715,
-0.013295621,
-0.0035424088,
-0.009640649,
0.043197524,
-0.014527187,
0.01958588,
-0.009931987,
-0.00027809566,
0.003317284,
0.006919285,
-0.023214366,
-0.04152895,
-0.014818526,
0.046375763,
0.021360395,
-0.018976718,
-0.009918745,
0.00008369769,
0.025823168,
0.013136709,
-0.01314333,
-0.018380798,
0.00035610315,
0.018010003,
0.02093663,
-0.029027889,
-0.64369875,
-0.05021613,
0.023611644,
0.0007072403,
0.026511787,
0.032338552,
0.0080978805,
-0.021598762,
-0.014858253,
0.02618072,
-0.0122163445,
0.016261974,
-0.006101551,
-0.0010238223,
-0.019665336,
-0.029107345,
-0.026326388,
-0.025558315,
0.016050093,
0.008932168,
-0.014196121,
0.017414086,
0.017321387,
0.016142791,
0.007740329,
0.03498708,
0.021519307,
-0.028365757,
0.01434179,
0.03088186,
-0.022207925,
0.02623369,
-0.0061677643,
0.005316924,
0.035596244,
-0.010719925,
-0.00914405,
-0.008720285,
0.016937349,
0.044045053,
-0.02913383,
-0.013527367,
0.011309223,
-0.0025144482,
-0.046481702,
0.03843017,
0.011507863,
0.006230667,
0.009461873,
-0.0018821117,
0.00043576595,
0.01289172,
-0.015109864,
-0.00010459624,
0.020870417,
-0.00078173017,
0.029478138,
-0.025558315,
-0.007170895,
0.0027528158,
0.008515024,
0.014686099,
0.006200871,
-0.033477418,
0.016328188,
0.028127389,
0.0151495915,
0.013110223,
0.0068994206,
0.0017728598,
0.017996762,
0.033053655,
-0.005710893,
-0.016897622,
0.013030767,
0.051460937,
0.0011272806,
0.0019549462,
-0.0049726153,
0.00069565297,
0.014752313,
-0.00005917809,
-0.015003922,
0.028524669,
0.0019201842,
-0.006535248,
-0.04502501,
0.022419807,
-0.000537155,
0.021625247,
0.02163849,
-0.0051182844,
-0.024565116,
-0.031358596,
0.0034232251,
0.039039332,
-0.006240599,
0.0051547014,
0.0019350823,
-0.043488864,
-0.007866134,
-0.0007151031,
-0.0072238655,
-0.012461334,
0.017996762,
0.015719026,
-0.033450935,
0.008323005,
0.022472776,
-0.046931952,
0.00419792,
0.0020079168,
0.0039562415,
-0.022697903,
-0.0040158336,
-0.028577639,
0.011653532,
0.025015365,
-0.013573716,
-0.023028968,
0.009938609,
0.008078016,
0.005201051,
-0.004323725,
0.0069590127,
-0.007104682,
-0.0056446795,
-0.0037145633,
0.0009874051,
-0.030908346,
0.0007502789,
-0.034616288,
0.022870056,
-0.020896902,
0.012362014,
-0.01789082,
0.009382417,
-0.0030342222,
-0.015096622,
-0.025015365,
-0.033450935,
-0.02823333,
0.018778078,
-0.007535068,
0.0041515706,
0.0054692146,
-0.008680557,
0.016950592,
0.009117564,
0.010362374,
-0.008521645,
-0.01039548,
-0.017771637,
0.0021469647,
0.011481377,
-0.017784879,
-0.0057870382,
-0.00859448,
0.00829652,
-0.0059327073,
-0.012719565,
0.0191886,
-0.0039562415,
-0.023254093,
-0.006104862,
0.00041548815,
-0.015242291,
0.03281529,
-0.00814423,
-0.030007845,
-0.02773011,
-0.012017705,
-0.012587139,
0.023399763,
0.0057903486,
-0.024048652,
-0.016209004,
-0.01199122,
0.00659484,
-0.029954875,
-0.00052267086,
-0.015798481,
-0.010839109,
0.017175717,
0.0132757565,
0.017851092,
0.015507143,
0.020751232,
0.012871856,
0.012401742,
-0.009097701,
-0.0071841376,
-0.013560474,
0.030299183,
0.0122163445,
-0.025558315,
0.012832128,
-0.01114369,
-0.014686099,
0.014897982,
0.031517506,
-0.006257152,
0.0383772,
0.003492749,
0.019413725,
0.0020708195,
0.0099717155,
-0.004413113,
0.019678578,
0.014076937,
0.02403541,
0.01084573,
-0.014527187,
0.006872935,
-0.025849653,
0.0011612149,
0.014752313,
-0.012858613,
-0.00025678327,
-0.02392947,
-0.025147792,
0.0038370579,
0.02749174,
-0.0056976504,
-0.0063531613,
0.0025972147,
-0.00034368815,
0.008779877,
0.024909426,
-0.00849516,
-0.017083019,
0.009190399,
0.030802405,
-0.0022909786,
0.032735832,
0.007866134,
0.022168197,
-0.006455792,
0.03443089,
0.0072635934,
0.005512253,
0.003443089,
0.010210083,
0.0038205045,
0.01434179,
0.0019400483,
0.031040773,
0.007250351,
0.0017182338,
0.036708627,
0.021227969,
0.0070583327,
0.012103782,
0.008448811,
0.0025458995,
-0.013487639,
0.00022429739,
0.019122386,
0.037847493,
0.013295621,
0.035622727,
-0.003717874,
-0.0017662385,
0.00013832362,
0.0036847673,
0.044389363,
0.0036748354,
-0.0072967,
-0.013315485,
-0.011905142,
-0.021863615,
0.0035225449,
0.007799921,
-0.019797763,
-0.0030938142,
-0.0053732055,
0.024472417,
0.009673756,
0.0015527008,
0.017917305,
0.0010147181,
-0.019943431,
0.024472417,
0.014845011,
-0.007190759,
-0.00384699,
0.007170895,
-0.014288819,
-0.021413365,
0.001863903,
0.012004462,
0.016897622,
-0.0027991652,
0.0017380979,
0.010368995,
0.017255174,
-0.003552341,
-0.0048832274,
0.0047408687,
0.011289359,
-0.0031616827,
-0.009475117,
0.020353952,
0.0005984022,
0.032709345,
-0.0060254056,
-0.013626687,
-0.0020542662,
-0.025968837,
0.0024200943,
-0.004651481,
-0.012030948,
-0.01808946,
-0.0054990104,
0.0072635934,
0.014209364,
0.009667135,
-0.020168556,
0.030166756,
0.0007059988,
0.0011454893,
-0.03318608,
-0.0048501207,
-0.03329202,
0.004936198,
0.030537551,
0.016354673,
0.008289899,
0.028657096,
-0.0007171723,
-0.022989241,
-0.03488114,
0.01868538,
-0.02783605,
-0.010004822,
0.004651481,
0.008667314,
0.003007737,
0.01654007,
0.02533319,
0.004082047,
-0.0025574868,
-0.0029928389,
0.011958113,
-0.01879132,
-0.007349671,
0.024975639,
0.024829969,
0.0345898,
-0.0119183855,
0.016765196,
0.024512146,
-0.0030209795,
-0.02538616,
-0.022446292,
0.03043161,
-0.015374716,
0.01853971,
-0.020075858,
-0.02392947,
0.017625967,
0.012673216,
-0.009686999,
0.009766455,
0.017851092,
0.011905142,
0.0030805715,
0.00914405,
0.0071841376,
-0.008309763,
0.0114019215,
0.0018357624,
0.016023606,
-0.022459535,
0.022168197,
-0.021519307,
0.012699702,
-0.007998561,
-0.0016727123,
0.0022926338,
-0.010958293,
0.0032345173,
-0.0125606535,
-0.021002844,
-0.008210443,
-0.011719746,
0.017374357,
-0.012540789,
-0.013798841,
-0.0016511929,
-0.0020857174,
-0.0121170245,
-0.018552953,
-0.012699702,
0.03167642,
-0.020976357,
-0.02263169,
-0.0014533808,
0.027703624,
0.013428047,
0.005581777,
-0.0092566125,
-0.013600201,
0.01953291,
-0.0056645437,
-0.00999158,
-0.013222787,
-0.03167642,
-0.024022168,
0.00056653714,
0.0007184138,
-0.0088858185,
-0.011050992,
0.005806902,
-0.000025502448,
0.025425889,
-0.009488359,
-0.032762315,
0.009872396,
-0.008078016,
0.015030408,
-0.009746591,
-0.02733283,
-0.018817807,
0.008481917,
-0.029557595,
-0.001878801,
-0.020671777,
-0.0061644535,
0.016738709,
-0.008958653,
-0.0046349275,
-0.0103425095,
-0.00049370254,
0.01834107,
-0.015374716,
0.008051531,
-0.008991759,
0.00989226,
0.0017033359,
-0.01314333,
0.01664601,
0.02143985,
0.007912483,
-0.0018076218,
0.0032841773,
0.043250494,
-0.014672857,
-0.023717586,
0.023121668,
0.00829652,
0.005101731,
-0.016857894,
-0.009898881,
-0.020949872,
0.022075498,
0.0020724747,
-0.007455612,
-0.007164274,
0.00014660027,
-0.011295981,
0.009177157,
0.000136151,
-0.01608982,
-0.0125606535,
0.0016859549,
-0.0027296413,
-0.015705783,
0.0076476303,
-0.033874698,
-0.0063233655,
0.049289145,
-0.01084573,
0.00018487981,
-0.025823168,
0.007872756,
-0.019943431,
-0.009554572,
0.011229767,
-0.042138115,
-0.0026452194,
-0.0038536112,
0.039383642,
0.022075498,
0.031411566,
0.012163375,
0.009190399,
0.023545433,
0.012832128,
0.0021502753,
-0.010302782,
0.011454892,
-0.024816727,
0.020486379,
0.014262334,
-0.006879557,
0.008038289,
-0.013997481,
0.015096622,
0.01659304,
-0.010799381,
0.0007275181,
0.0065153837,
-0.030060817,
-0.04362129,
0.017334629,
0.00088725757,
0.008700421,
-0.024525387,
-0.0071444097,
0.025558315,
0.0006170247,
-0.0076211453,
-0.014368275,
0.029742992,
-0.0071444097,
-0.017109504,
-0.0020012956,
-0.00529706,
-0.012845371,
-0.0033156285,
-0.00054336246,
0.0055387383,
0.014487459,
0.0282863,
0.021625247,
0.019599123,
0.0010784484,
-0.017612725,
0.014871496,
-0.0006567527,
0.0037211848,
0.01744057,
-0.020248013,
-0.013010904,
-0.017904064,
-0.02953111,
-0.023452733,
0.0055983304,
0.009501602,
-0.011534348,
0.008157472,
-0.0021039261,
-0.014831768,
0.023518946,
-0.008270035,
0.025452374,
-0.031014286,
0.03413955,
0.0012083919,
-0.0002913383,
-0.03003433,
0.0031385082,
-0.00055288064,
-0.0036185542,
0.011329087,
0.050586924,
0.0034397785,
-0.017851092,
0.0024002304,
0.0044429093,
-0.009905502,
-0.047329232,
0.017215446,
0.024909426,
0.0019367376,
-0.028312786,
-0.025929108,
-0.024697542,
0.030511066,
0.0069325273,
-0.007799921,
-0.011348952,
-0.005250711,
-0.014937709,
0.02833927,
-0.03522545,
0.023068696,
0.011077477,
-0.025677498,
-0.018605923,
-0.022168197,
-0.0023224298,
0.01704329,
-0.00025761093,
0.032206126,
0.008786499,
-0.014871496,
0.001596567,
-0.010150491,
0.011309223,
0.011885279,
-0.008435568,
0.038906906,
0.0034364676,
-0.0066147037,
0.027915506,
0.0014285509,
0.0010172011,
-0.010183598,
0.00026692217,
0.009501602,
-0.040231172,
-0.008561374,
0.045846056,
0.0076674945,
-0.022830328,
0.009488359,
-0.023148153,
0.0029547664,
-0.011037749,
-0.010872216,
0.004191299,
-0.04788542,
0.003942999,
0.00028657922,
0.034060095,
0.026061535,
0.02722689,
-0.016579797,
-0.0038370579,
0.039357156,
-0.02388974,
0.012050811,
0.017069776,
-0.0011802512,
-0.014381518,
0.014196121,
-0.002413473,
-0.032047212,
-0.007005362,
0.0007713844,
-0.019877218,
-0.027941993,
0.01583821,
0.025624529,
-0.0024217498,
-0.040257655,
0.024816727,
0.01544093,
0.011050992,
-0.0036086221,
-0.010276296,
0.02273763,
-0.008607723,
-0.0061479,
0.0064226855,
-0.021519307,
0.015003922,
0.023095181,
-0.011706503,
0.0077270865,
-0.0010163734,
-0.00839584,
-0.006406132,
0.024909426,
-0.012461334,
0.0023406383,
-0.023757314,
-0.01374587,
-0.017374357,
0.0042409585,
-0.015679298,
-0.031861816,
-0.022896541,
-0.010918565,
-0.011289359,
0.0151495915,
-0.029372199,
-0.0016528483,
-0.012626867,
-0.028471697,
-0.03443089,
-0.0100909,
-0.03223261,
0.011454892,
0.020605564,
0.00019450142,
-0.04367426,
-0.026246933,
-0.0457666,
-0.019890461,
-0.003602001,
-0.000008748684,
0.0059856777,
0.014871496,
-0.032947715,
0.035967037,
-0.019373998,
0.0057473104,
-0.003512613,
-0.0122891795,
0.025372917,
0.0036913888,
0.022128468,
0.008031667,
-0.02749174,
-0.026392601,
0.019109145,
0.011898521,
-0.028206846,
0.02428702,
-0.017665695,
0.015666055,
-0.015030408,
0.000792076,
-0.014355033,
0.0002749919,
0.013984239,
-0.0068067224,
0.0001430827,
-0.008263414,
0.0008500126,
0.0029746303,
0.016156033,
-0.018950233,
0.008117745,
0.012547411,
0.001993019,
-0.025015365,
0.012037569,
-0.009302962,
0.020155314,
0.03991335,
0.0076741157,
0.022525748,
0.0042078523,
0.010263054,
0.008892439,
0.012527547,
-0.0070848176,
-0.007965454,
0.001061895,
-0.008117745,
-0.008561374,
0.0053996905,
-0.002972975,
-0.017149232,
-0.0041648136,
0.013679658,
-0.02533319,
-0.016910864,
0.009931987,
0.0048434995,
-0.0008334593,
0.0067504407,
-0.008832848,
-0.005677786,
-0.017467055,
-0.017135989,
-0.0017231998,
-0.006690849,
0.0017496852,
-0.0058896686,
-0.0073629133,
0.031199684,
0.004376696,
-0.009163914,
-0.02313491,
-0.004727626,
0.19196546,
0.028789522,
-0.013904783,
0.02643233,
0.013163194,
0.0051646335,
0.0356757,
-0.013573716,
0.0022115225,
0.021479579,
0.02553183,
-0.003737738,
-0.004274065,
0.001933427,
0.019069416,
0.0050156536,
0.0033354925,
-0.022313865,
-0.020115586,
-0.02408838,
0.0046912087,
0.0052043614,
0.018023247,
0.0055552917,
0.026498543,
-0.01414315,
0.0019499803,
0.011322466,
0.031835333,
0.012507683,
-0.014725827,
0.014010724,
0.013136709,
0.012176617,
-0.01644737,
-0.006200871,
0.00037224262,
0.00082642416,
0.005578466,
0.00784627,
-0.018658893,
-0.021744432,
-0.029239772,
-0.0067471303,
-0.0077668144,
0.023452733,
-0.0033619779,
-0.0031567167,
-0.016526828,
0.012785778,
-0.046375763,
0.004668034,
0.023664616,
0.014010724,
0.0026617728,
-0.0024598222,
0.044309907,
-0.0010925187,
-0.013044011,
0.0046812766,
-0.019082658,
0.0021751053,
-0.025372917,
0.01814243,
-0.012527547,
0.015096622,
-0.030643493,
0.0018026558,
0.0044991905,
-0.006700781,
0.014076937,
-0.00814423,
-0.008521645,
0.015997121,
0.00055412215,
-0.02433999,
0.0138915405,
0.00859448,
-0.0031335421,
0.020274498,
-0.0017927238,
0.0026717046,
0.0024714095,
0.010329267,
-0.031835333,
-0.040231172,
0.011660153,
0.0132757565,
-0.012017705,
-0.014897982,
-0.001849005,
-0.011593941,
-0.014845011,
-0.020075858,
0.01978452,
0.010448451,
-0.02513455,
0.021492822,
0.022724388,
0.01363993,
-0.022353593,
0.0493686,
0.018301342,
0.030749433,
0.0026419086,
0.010481558,
-0.018725106,
-0.00084918493,
0.0015138005,
-0.019956674,
0.013600201,
-0.021016086,
0.022366837,
-0.008627587,
0.0030193243,
0.0191886,
-0.015123107,
-0.046402246,
0.018354313,
-0.0023720898,
0.0049295765,
-0.0028405485,
-0.0075681745,
0.02079096,
-0.031120228,
0.00023609163,
-0.028312786,
-0.009031488,
-0.003462953,
-0.033450935,
0.002307532,
-0.022803843,
0.011084098,
-0.0007953867,
0.019016445,
-0.0209896,
0.018327828,
-0.009773076,
-0.020353952,
0.0014840044,
-0.013123467,
0.0016056714,
-0.0043700747,
0.009415524,
-0.013759114,
0.013249272,
0.012454713,
0.009210263,
-0.022724388,
-0.018857533,
-0.02263169,
-0.03827126,
0.0059227752,
-0.008084638,
0.029107345,
-0.03607298,
0.003717874,
-0.016579797,
-0.007190759,
0.013732628,
-0.033053655,
0.009673756,
0.04338292,
0.0012166685,
-0.0067040916,
-0.006204182,
-0.16706927,
0.014302062,
0.01744057,
-0.03178236,
0.01089208,
0.0052540214,
0.011547591,
-0.013328727,
-0.025611285,
-0.00065137283,
0.036814567,
0.0007618662,
-0.03302717,
0.004711073,
-0.01544093,
0.0038834072,
-0.008223685,
0.03403361,
0.019625608,
0.028498184,
0.013328727,
-0.011706503,
-0.0015055238,
-0.024353234,
0.006210803,
-0.0064690346,
-0.014964195,
-0.023876498,
-0.010428587,
0.005290439,
-0.0003819677,
0.028630609,
0.030590521,
-0.009091079,
-0.01089208,
-0.0041350173,
-0.013017525,
0.0052738856,
-0.000690687,
-0.002928281,
0.02394271,
0.024353234,
0.020353952,
-0.005356652,
-0.02293627,
0.02273763,
-0.0008011803,
-0.007230487,
0.03917176,
-0.0067074024,
0.024300262,
-0.00769398,
0.014474217,
-0.008826226,
-0.002903451,
0.0057539316,
0.00904473,
0.015003922,
0.032391522,
0.00078504084,
-0.021373637,
-0.017016806,
0.025041852,
0.0046845875,
-0.020499622,
-0.042349994,
-0.029398683,
0.0036549715,
-0.021214725,
0.0009857498,
-0.008852712,
-0.0146066435,
0.016381158,
-0.006925906,
0.017917305,
0.0064226855,
-0.0072768363,
0.035967037,
-0.01699032,
0.010263054,
0.0049262657,
0.0061876285,
-0.00914405,
-0.019321026,
0.0059327073,
0.00207413,
0.021161756,
0.01958588,
-0.024260536,
-0.015864694,
0.014050452,
-0.039304186,
-0.0020079168,
0.0017331318,
0.012249451,
0.017904064,
-0.0048699845,
0.003203066,
-0.003203066,
-0.011713124,
0.020300983,
-0.01893699,
-0.035808127,
-0.0064127534,
0.018725106,
0.0017049912,
0.0045455396,
0.023624888,
0.031835333,
-0.0072371084,
-0.015917666,
-0.00829652,
0.014739069,
0.00040307315,
-0.020605564,
0.02392947,
-0.009077837,
-0.005902911,
0.011295981,
-0.013851812,
0.058956277,
0.0010685163,
0.023095181,
0.0032328619,
0.007515204,
-0.012686458,
-0.12416309,
-0.010004822,
0.0034099824,
0.0133485915,
-0.011302602,
0.022141712,
-0.01544093,
0.030352155,
-0.024644572,
0.023267336,
-0.008998381,
-0.015970636,
-0.023624888,
-0.0089851385,
0.016924107,
-0.005277196,
-0.006972255,
-0.0009137429,
-0.009481737,
0.015520386,
0.0025161034,
0.0039562415,
-0.0070848176,
0.0013797187,
-0.004707762,
0.0056546116,
-0.025598044,
0.0038734751,
0.020870417,
0.038244773,
-0.0019880529,
-0.014023966,
0.018950233,
0.0063233655,
-0.033874698,
-0.0153217465,
-0.022340352,
-0.048865378,
0.01868538,
-0.040601965,
0.0045389184,
0.0013929612,
0.0053136135,
-0.009614164,
-0.015268776,
0.015401202,
-0.04462773,
-0.010719925,
0.033159595,
-0.01269308,
-0.026591241,
-0.03662917,
-0.00839584,
-0.007932347,
0.009408903,
-0.011183418,
0.008157472,
0.0065484904,
-0.01454043,
0.025902623,
-0.0126334885,
-0.0026568067,
-0.013878297,
0.01363993,
0.016698983,
0.0026319767,
0.0028620677,
-0.027200403,
0.0068067224,
-0.0017314765,
0.0080978805,
-0.008554752,
-0.023624888,
-0.015030408,
0.012554033,
-0.0114747565,
-0.00539638,
-0.0016967145,
0.0018672136,
-0.021479579,
-0.018698622,
-0.017798122,
0.016248731,
-0.013295621,
0.035410848,
0.0040588723,
0.00034844724,
-0.029319227,
0.012368635,
0.00162388,
0.035543274,
0.04062845,
0.010256433,
-0.02722689,
-0.008567994,
0.010024686,
-0.012712944,
0.011249632,
0.006985498,
0.024260536,
-0.025399404,
-0.023201123,
-0.0583736,
0.0037112527,
0.019268056,
-0.00095181545,
0.009753211,
-0.010501422,
0.014302062,
-0.0075747957,
0.013527367,
0.02373083,
-0.02998136,
0.021797402,
-0.015970636,
0.02708122,
-0.018778078,
0.0073364284,
0.03196776,
0.010117385,
0.017533269,
0.024392962,
-0.013494261,
-0.0034000503,
-0.0058929794,
0.013315485,
-0.01679168,
0.0119183855,
-0.005306992,
0.01454043,
-0.018023247,
-0.0069788764,
0.025161035,
-0.030007845,
-0.006574976,
0.012315664,
-0.0043535214,
-0.010931808,
0.0013159884,
0.03742373,
0.008289899,
0.017453812,
-0.010971536,
-0.046587642,
0.028206846,
-0.0074688545,
0.0003896236,
0.0029398683,
-0.015334989,
0.0025293462,
0.0018721797,
-0.0010114074,
-0.009117564,
-0.002218144,
0.00008680143,
-0.017414086,
-0.0040158336,
-0.008799741,
-0.012653352,
-0.0029067616,
-0.026088022,
-0.024075137,
0.024498902,
0.02043341,
-0.0009352622,
0.009117564,
0.022049012,
-0.0073893988,
-0.018844292,
-0.011123826,
0.0110576125,
-0.014222606,
-0.031252656,
-0.011289359,
-0.009197021,
0.020459894,
0.0035059915,
0.0034662636,
-0.0118919,
0.008084638,
0.0056976504,
0.027200403,
0.02268466,
0.0070980606,
0.0068596927,
0.02158552,
0.031040773,
-0.01019684,
0.0019582568,
0.017678939,
0.01963885,
0.005542049,
-0.012275937,
0.012580518,
0.01234215,
-0.017347872,
0.00018519019,
0.010236569,
-0.012150131,
0.010666954,
0.02053935,
0.026803125,
-0.008667314,
0.01403721,
-0.000547087,
0.0019483248,
-0.008382598,
0.005575156,
-0.024406204,
-0.026273418,
-0.029690022,
-0.013467776,
0.005691029,
0.00509511,
0.03742373,
-0.0031385082,
-0.0137193855,
-0.0073231854,
-0.0036384182,
0.003552341,
-0.012640109,
0.017957034,
0.004671345,
0.005340099,
0.018420527,
0.016963834,
-0.004416424,
0.00028492388,
0.021598762,
-0.012977798,
0.016129548,
-0.026419086,
-0.0077072224,
-0.03196776,
-0.00087235955,
0.0009137429,
-0.0011214869,
-0.018672137,
0.014249092,
0.01628846,
-0.025452374,
0.0942347,
0.015705783,
-0.021254454,
-0.00084049447,
-0.031093743,
0.008382598,
0.018023247,
0.0060684443,
-0.025942352,
-0.035066538,
0.0010701717,
-0.015017165,
0.01684465,
-0.0365762,
-0.03628486,
0.0037311167,
0.003893339,
0.008256792,
0.006839829,
-0.019599123,
0.018221887,
-0.017652452,
0.004532297,
0.017586239,
-0.017228687,
-0.006972255,
0.022300623,
-0.0063664042,
-0.004658102,
-0.035967037,
-0.011971355,
-0.00046266508,
-0.0040489403,
-0.018711865,
0.017414086,
-0.02053935,
0.004631617,
-0.017202202,
-0.0072238655,
0.032206126,
-0.0076079024,
0.016579797,
-0.018460255,
-0.026525028,
-0.018579438,
-0.018897261,
-0.022194682,
-0.010865594,
0.001888733
] |
The aim of this study is to search the most powerful prognostic factor from routine blood test for esophageal squamous cell cancer (ESCC) patients. Multiple laboratory tests were evaluated including those reflecting red blood cell parameters (hemoglobin (Hb), mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), and red blood cell distribution width (RDW)), platelet morphological parameters (mean platelet volume (MPV) and platelet count (PLT)), blood coagulation status (D-dimer), and tumor biomarker (CA19-9). Known inflammatory indices (N
|
[
-0.015020453,
0.00012999112,
0.03565853,
-0.03573878,
-0.009810777,
0.0044640037,
-0.013428794,
-0.009255703,
-0.029639648,
-0.008700628,
-0.0082124295,
0.024222655,
0.02400865,
0.0022654403,
-0.021079462,
0.011676631,
0.039162856,
-0.00789811,
-0.011964199,
-0.007450038,
-0.01849803,
-0.0006604051,
-0.004571006,
-0.0011034616,
-0.004744885,
0.038333587,
0.02216286,
-0.0296664,
0.005219708,
-0.0048552314,
0.030522417,
-0.0016159025,
-0.007376474,
-0.024222655,
-0.019140044,
0.0063599516,
0.0016376374,
-0.0069819028,
0.02923839,
-0.011074742,
0.02148072,
-0.007042092,
-0.005106018,
-0.01665224,
-0.013749801,
-0.010118409,
0.0025212427,
-0.035471275,
-0.024610538,
0.011984263,
0.0070621544,
-0.004711447,
-0.0062128236,
0.0021985637,
-0.0061894166,
0.0043068444,
0.013348542,
0.040580638,
0.0044171903,
-0.03734382,
0.0014930171,
-0.0027352474,
-0.025386306,
0.007169157,
-0.0006319826,
0.010064907,
-0.006242918,
0.010245474,
0.011656567,
0.020236818,
0.022202985,
0.029532647,
-0.012091265,
0.007938236,
0.027258847,
-0.016585363,
-0.050398104,
-0.0070822174,
0.013910305,
-0.010245474,
0.013910305,
-0.011516127,
-0.017428007,
0.008158929,
0.0063465764,
0.013870179,
-0.010064907,
0.00080795126,
-0.01185051,
0.0133351665,
0.012713215,
0.014819824,
0.0055674654,
-0.0038153022,
-0.024316283,
-0.0038420528,
0.023767896,
0.045850504,
0.01690637,
-0.029880404,
0.0013927023,
-0.01738788,
-0.01576947,
-0.006791305,
-0.016638864,
-0.004032651,
-0.012318645,
-0.008673877,
0.011750194,
-0.0050257663,
-0.0057981894,
0.028863883,
-0.001059992,
-0.017066874,
0.033678986,
-0.010579856,
0.012311957,
0.008319432,
-0.02469079,
-0.0019009635,
-0.01244571,
0.00003168795,
0.036247045,
-0.029933905,
0.028596375,
0.0030729736,
-0.0433627,
-0.013361918,
0.012178204,
-0.014645945,
0.000044436274,
-0.009677025,
0.0028790317,
0.010767111,
-0.014686071,
-0.0039423676,
-0.024075527,
-0.0030595982,
-0.032234456,
-0.022243112,
-0.006901651,
0.031164432,
0.016344607,
-0.03153894,
-0.031164432,
0.0029893778,
0.023005504,
0.025560185,
0.02716522,
-0.01105468,
0.0006073219,
-0.02474429,
0.03512352,
0.005941974,
-0.0016819431,
-0.0021149681,
0.014124309,
0.016505111,
-0.008165617,
-0.03153894,
-0.019688431,
0.0020631389,
0.013422106,
-0.0063666394,
0.003805271,
0.031993702,
0.009442957,
-0.0063967337,
-0.0010892504,
0.0033220884,
-0.020437447,
0.037210066,
-0.042560183,
0.0012606214,
0.004012588,
0.018591657,
0.007436663,
0.020597951,
-0.030709673,
-0.019621555,
-0.015675843,
0.038039334,
0.03434775,
-0.01761526,
-0.0075771036,
0.009570022,
0.030870175,
-0.0069685276,
-0.0142580625,
-0.033090476,
0.015649093,
0.018324152,
0.014030682,
-0.012138078,
-0.63644993,
-0.02198898,
0.0071156556,
-0.003143194,
0.025894567,
0.0061392593,
0.035391025,
-0.004878638,
-0.0091353245,
0.022296613,
-0.0116097545,
0.018845787,
-0.009951218,
-0.01139575,
0.0015415025,
-0.044058215,
-0.042747434,
-0.009971281,
0.0012739967,
0.0131679755,
-0.030014157,
0.021627849,
-0.0024108966,
0.016170729,
0.005510621,
0.026162073,
0.023553891,
-0.007964986,
-0.0074232873,
0.01096774,
-0.004203186,
0.020905582,
0.0006875736,
0.006333201,
0.04756254,
-0.022764748,
-0.009456332,
0.009616835,
0.0042834375,
0.032608964,
0.0020414041,
-0.004025963,
0.0077309194,
-0.0025479933,
-0.035257272,
0.022483867,
-0.002497836,
-0.0056176228,
0.0020380602,
-0.006239574,
-0.0057948455,
-0.0006604051,
-0.010773798,
0.007771045,
0.001381835,
-0.003136506,
0.016291106,
-0.027258847,
-0.0028405779,
-0.000567614,
-0.0018708691,
0.015100705,
-0.009884342,
-0.027954362,
0.011964199,
0.024878044,
0.0010081627,
0.005560778,
0.0036347357,
0.01258615,
0.01690637,
0.0059820996,
-0.008185679,
0.0059520053,
0.039055854,
0.026162073,
0.010419353,
0.0042600306,
-0.014003932,
0.0021417188,
0.020303695,
0.019822184,
-0.014498818,
0.00787136,
0.01437844,
-0.011335561,
-0.04063414,
-0.0026265732,
0.01693312,
0.015689218,
0.015956724,
0.0007030388,
-0.0012923876,
-0.026188822,
-0.01233202,
0.012204954,
-0.003574547,
0.011007866,
0.015007079,
-0.042720687,
-0.02832887,
-0.017735638,
-0.0020932334,
-0.0031532252,
0.013047598,
0.015261209,
-0.019247046,
-0.011121556,
0.028007863,
-0.04750904,
0.00912195,
-0.010486229,
-0.009356017,
-0.008861131,
0.012980722,
-0.028863883,
0.020437447,
0.017468132,
-0.020731704,
-0.017494883,
0.013388668,
0.006105821,
0.012800155,
-0.0137096755,
-0.00034127897,
-0.006319826,
-0.011074742,
-0.012525962,
-0.009630211,
-0.028703379,
0.0074968515,
-0.014793074,
0.015929973,
-0.023794645,
0.025025172,
-0.011228559,
0.013341854,
-0.019247046,
-0.021560973,
-0.030709673,
-0.02082533,
-0.015247834,
0.019942561,
-0.01670574,
-0.007149094,
-0.0060255695,
-0.010546418,
-0.0006691826,
0.012298582,
0.0049053887,
-0.010098346,
-0.020758454,
-0.015756095,
0.003444138,
0.0088410685,
-0.014431941,
-0.014512192,
-0.015608966,
0.0009437941,
-0.024302907,
0.0027887486,
0.0029726587,
-0.001322482,
-0.008192367,
0.004878638,
-0.0021617818,
-0.012659715,
0.017468132,
-0.015608966,
-0.019247046,
-0.0019293859,
-0.004015932,
-0.0094697075,
0.011636505,
-0.019420926,
-0.0026115258,
-0.026309201,
-0.0055908724,
-0.006222855,
-0.026442954,
0.013910305,
-0.008767504,
-0.011335561,
0.007088905,
0.027058218,
0.034963015,
0.011034616,
0.0069350894,
0.0046044444,
0.0019812153,
-0.018096771,
-0.0061325715,
-0.028409122,
0.018792287,
0.016317857,
-0.015194332,
-0.0071624694,
0.0006311466,
0.0057948455,
0.030281663,
0.019086543,
-0.0069819028,
0.024088902,
0.001003983,
0.032180954,
-0.015582216,
0.011937449,
0.0037083,
0.010593232,
0.032234456,
0.010439416,
0.0009362705,
-0.0116097545,
0.0014512193,
-0.021467345,
0.0023958492,
0.016518487,
0.0020731704,
-0.006296419,
-0.013636111,
0.004393784,
0.00011807876,
0.01986231,
0.010212036,
-0.00869394,
-0.007891423,
0.027499601,
0.02605507,
0.0033571986,
-0.005109362,
-0.015782846,
0.0038487406,
0.0010658436,
-0.019969312,
0.03597954,
-0.0038420528,
0.025252553,
0.0012029404,
0.016826117,
-0.0017939612,
-0.0044907546,
0.027285596,
0.006446891,
0.0020564513,
0.017922893,
-0.020691577,
0.027767107,
0.008566875,
-0.010619982,
0.03017466,
0.0047549168,
0.027472852,
-0.010439416,
0.021855228,
-0.0073296605,
-0.010733672,
-0.004571006,
0.018364277,
0.026790712,
0.011776946,
0.038868602,
-0.014298188,
-0.0029994093,
-0.010345789,
-0.01247246,
0.006654208,
0.014338314,
-0.0019310579,
-0.023794645,
-0.007597166,
-0.01988906,
-0.0058316276,
-0.001230527,
-0.030040907,
-0.0010558121,
0.005346773,
0.023834772,
0.018939415,
0.017896142,
0.01786939,
-0.0011168369,
-0.016612114,
0.024543662,
0.03651455,
-0.013422106,
-0.022871751,
-0.011469314,
0.017655386,
-0.024289532,
0.0122852065,
0.024851294,
0.010238786,
-0.004978953,
-0.010486229,
-0.0148465745,
0.0131679755,
0.008359558,
-0.008239181,
0.022457117,
0.00878088,
-0.0016953184,
-0.01346892,
-0.01786939,
-0.004517505,
0.031351686,
0.01718725,
-0.0049990155,
-0.012318645,
-0.0056410297,
0.0002591463,
-0.026790712,
-0.03065617,
-0.014391815,
0.016077101,
-0.0052631777,
0.0341605,
0.0067745857,
0.0022386897,
0.02102596,
0.0037852079,
-0.007095593,
-0.036728553,
-0.003235149,
-0.01897954,
0.02531943,
0.025881192,
-0.008546812,
0.0058215964,
0.014940202,
0.0017705543,
-0.00843981,
-0.024985047,
0.023861522,
0.0054571196,
-0.004032651,
-0.0023189413,
0.024530286,
0.01440519,
0.013896929,
0.02145397,
-0.015154207,
-0.02622895,
-0.011382374,
0.0009580053,
-0.028730128,
-0.011148307,
0.019247046,
0.044245467,
0.02671046,
-0.001154455,
-0.00026395303,
-0.005313335,
0.026844213,
0.00639339,
-0.024530286,
0.023794645,
-0.0012372145,
0.013402043,
-0.015221084,
-0.012873719,
0.022684496,
-0.008386308,
-0.007042092,
0.007978362,
0.0062261987,
0.024623914,
-0.0036180166,
0.010111721,
0.007964986,
-0.007831234,
0.015033829,
0.004634539,
0.0017638667,
-0.018203773,
0.036835555,
-0.015100705,
-0.017240752,
-0.012860344,
0.007657355,
0.0052431147,
-0.0007419108,
0.005707906,
-0.008921321,
0.00033542726,
-0.010379227,
-0.019113293,
0.0343745,
0.0058383155,
-0.012833593,
0.007470101,
-0.019554678,
-0.027111718,
-0.020330446,
0.0047549168,
-0.0008284322,
-0.027312348,
-0.023179382,
0.020370571,
0.015261209,
-0.004952202,
0.0008497491,
-0.016558612,
-0.0057747825,
0.0052498025,
-0.011583003,
0.015729344,
0.009850903,
-0.02534618,
-0.0011853853,
-0.010265538,
0.0013208102,
-0.008366246,
-0.014003932,
0.014017307,
0.00041944082,
0.003328776,
-0.013060973,
-0.016999997,
0.0013701315,
0.004293469,
0.010579856,
0.007048779,
-0.028007863,
-0.010031469,
-0.01849803,
-0.041356403,
-0.014980328,
-0.000321216,
0.016505111,
0.010084971,
-0.015261209,
-0.0025362899,
-0.0028338903,
-0.004159716,
0.025747439,
-0.02418253,
0.004142997,
0.00032832165,
0.00835287,
0.0160236,
-0.010272224,
0.031458687,
0.019782059,
-0.013749801,
-0.010078283,
0.010245474,
0.026309201,
-0.003781864,
-0.014619195,
0.007229346,
-0.0088410685,
-0.019554678,
-0.020437447,
-0.009362705,
-0.022577494,
0.025212428,
-0.0142580625,
-0.006600707,
-0.010379227,
-0.0013968821,
0.011382374,
0.0060021626,
-0.006092446,
-0.0017906174,
-0.015956724,
0.02542643,
0.009242327,
-0.008245868,
0.02628245,
-0.027058218,
-0.0053969305,
0.03383949,
-0.008520061,
-0.009081824,
0.0035310772,
-0.0008869491,
-0.023286385,
-0.017936267,
-0.014458692,
-0.02210936,
-0.023647517,
-0.016371358,
0.033705737,
0.03517702,
0.038574345,
0.017468132,
0.023393387,
0.016357983,
0.012011013,
0.0044874107,
-0.010198661,
0.011843822,
-0.00024326313,
0.017254127,
0.0024443348,
-0.022376865,
-0.0052063325,
-0.029479146,
0.025894567,
0.019875685,
0.0014136012,
-0.00029425643,
-0.0036648302,
-0.042372927,
-0.029505895,
0.03255546,
-0.010533043,
0.0062696687,
-0.034401253,
-0.010780486,
0.022858376,
0.0039624306,
-0.022724623,
-0.0116966935,
0.018310776,
-0.0056042476,
0.008132178,
-0.026844213,
0.00023051481,
-0.0051929574,
-0.008774192,
0.004841856,
-0.03140519,
0.01372305,
0.010907551,
0.022818249,
0.016692365,
-0.013843428,
-0.0023306448,
0.0012221674,
-0.023714393,
-0.006112509,
0.020704953,
-0.02881038,
-0.014391815,
-0.009670337,
-0.0082525555,
-0.022818249,
0.008727378,
0.020103065,
-0.014003932,
0.01758851,
-0.035337523,
0.011843822,
0.0094697075,
-0.0025964787,
0.021239964,
-0.027633354,
0.032073952,
0.012412271,
-0.01639811,
-0.03565853,
0.00009064896,
-0.0069551524,
-0.0015874801,
0.02696459,
0.03667505,
-0.020932334,
-0.02168135,
-0.006299763,
0.008593625,
-0.0046813525,
-0.028623126,
0.024784418,
-0.012412271,
0.0003935262,
-0.013977181,
0.00077075127,
-0.028409122,
0.019541303,
0.0048853257,
-0.025640436,
0.0011870572,
-0.008660502,
-0.0045308806,
0.023660893,
-0.03750432,
0.011027928,
0.016692365,
-0.030361915,
-0.017294254,
-0.018056646,
-0.027151844,
0.0075369775,
-0.009335955,
0.030067658,
0.0034173874,
0.0012062842,
0.006460266,
-0.0061426032,
0.018457904,
-0.003044551,
-0.013736426,
0.04290794,
-0.007022029,
-0.0023473639,
0.018992916,
-0.024195904,
0.009797402,
-0.011342248,
-0.016438235,
-0.0019895749,
-0.043710455,
-0.0047181346,
0.04464673,
0.003365558,
-0.02105271,
0.00003017278,
-0.017936267,
0.0042800936,
-0.04202517,
-0.01571597,
-0.0024125683,
-0.028542874,
-0.01920692,
0.006771242,
0.01301416,
0.04432572,
0.008473248,
-0.0046412265,
-0.0065639247,
0.029800152,
-0.0296664,
0.029184889,
0.010680172,
0.0080853645,
-0.011817072,
0.003024488,
-0.015060579,
-0.042239174,
-0.0079984255,
-0.009075136,
-0.013047598,
-0.03517702,
0.0014997047,
0.015100705,
0.0057781264,
-0.012338707,
0.00047231503,
0.033678986,
0.020838706,
0.006500392,
-0.017949643,
0.0109811155,
-0.021761602,
-0.012091265,
0.0015924958,
-0.011817072,
-0.004781667,
0.008600313,
-0.0077041686,
0.0005659421,
-0.003328776,
-0.015501964,
-0.0056109354,
0.022296613,
-0.017200626,
0.005935286,
-0.032100704,
0.008205742,
-0.0038654597,
0.02309913,
0.006089102,
-0.014806449,
-0.013575922,
-0.029907154,
0.022497242,
0.007015341,
-0.037183315,
0.005958693,
-0.007844609,
0.007436663,
-0.012726591,
-0.0030913646,
-0.014712822,
0.018083395,
0.032528713,
-0.016250981,
-0.030923678,
-0.0004480723,
-0.04852556,
-0.019166794,
-0.013288354,
0.030950427,
0.019728556,
0.021132963,
-0.01571597,
0.03020141,
-0.009021635,
0.011489376,
0.0028071397,
-0.01872541,
0.004146341,
0.00006071129,
0.0060456325,
0.0059954748,
-0.03335798,
-0.013000784,
0.03750432,
0.0048585753,
-0.012091265,
0.028221868,
-0.0037684888,
0.01025885,
-0.00043218915,
0.0024710854,
-0.0054337126,
-0.008493311,
0.00018359679,
0.00013333495,
-0.011134931,
0.019327298,
-0.0072159707,
-0.004025963,
-0.0002004204,
0.018631782,
-0.008660502,
0.002362411,
-0.012893782,
-0.029318642,
0.02329976,
-0.018899288,
-0.005744688,
0.022537367,
-0.007256096,
0.028221868,
0.020691577,
0.01153619,
-0.0034123715,
0.016638864,
-0.011583003,
-0.0073296605,
-0.004353658,
-0.021092836,
-0.032635715,
0.0022804874,
-0.0069551524,
0.0052163643,
0.0030729736,
-0.011241933,
-0.022818249,
-0.018658534,
0.014485442,
-0.012298582,
-0.0054203374,
-0.009422894,
-0.000283807,
-0.026884338,
-0.016745867,
-0.0102856,
-0.014191186,
-0.01326829,
-0.003952399,
-0.016665615,
0.010131785,
0.0042633745,
0.0037584573,
-0.01923367,
0.003628048,
0.0033555266,
0.19453026,
0.0069885906,
-0.006443547,
0.027499601,
0.019982688,
-0.013295041,
0.014900076,
-0.0024376472,
0.030121159,
0.022577494,
0.03750432,
-0.0024660695,
-0.0026198854,
0.001040765,
0.016384734,
-0.0035611717,
-0.028542874,
-0.01804327,
-0.008433122,
-0.018819036,
-0.017749013,
0.004554287,
0.010920927,
-0.004176435,
0.012546024,
-0.021320216,
0.0058149085,
0.002476101,
0.02721872,
0.007028716,
-0.019327298,
0.016665615,
-0.00518627,
0.019929186,
-0.003728363,
-0.0032050544,
0.013595985,
-0.007456726,
-0.012867032,
0.0028121553,
-0.014057432,
-0.008018488,
0.0032017108,
0.0023607393,
0.006202792,
-0.0025814315,
-0.015301335,
0.002683418,
0.0012974034,
-0.020811956,
-0.05128087,
0.005637686,
0.01940755,
0.028168367,
0.012184892,
-0.009175451,
0.032341458,
-0.010111721,
-0.027352473,
-0.0014227967,
-0.016464986,
-0.015461839,
-0.029024385,
0.035872534,
-0.012017701,
0.038601093,
-0.025948068,
-0.018899288,
0.0030813331,
-0.0075369775,
0.014311563,
-0.022122733,
0.0063398886,
-0.0054604635,
-0.0033872928,
-0.012405584,
0.0205177,
0.018819036,
0.0006252949,
0.027258847,
-0.009891029,
0.012057827,
-0.019099917,
-0.005132769,
-0.023059005,
-0.01935405,
-0.0037785203,
0.028997635,
-0.034321003,
-0.012064514,
0.0002873598,
0.0008618704,
-0.018538157,
0.009697087,
0.034989767,
0.029693149,
-0.009784027,
0.021092836,
-0.0077041686,
-0.0073162853,
-0.03424075,
0.05794177,
0.011669943,
0.006543862,
-0.0045843814,
-0.0018959477,
-0.017668761,
0.005687843,
0.015662467,
-0.0035712032,
0.0028656565,
-0.03386624,
-0.0008179828,
-0.00946302,
0.0039457115,
0.0034508256,
-0.0013141225,
-0.019982688,
0.021320216,
-0.016759241,
0.011188433,
-0.029559396,
0.028516125,
0.016959872,
-0.009743901,
0.00033375536,
-0.008433122,
-0.006296419,
-0.007610542,
-0.031913448,
-0.00798505,
-0.005182926,
-0.00020972041,
0.004540912,
0.024784418,
0.0007490164,
-0.019594803,
-0.012044451,
-0.010680172,
-0.0055875285,
0.0044640037,
-0.008413059,
-0.0073162853,
0.023112506,
-0.0019193545,
0.0011995966,
0.0023925055,
0.016411483,
-0.030549169,
-0.014993703,
-0.042265926,
-0.019126669,
-0.0077643576,
-0.015194332,
0.025078675,
-0.023259634,
-0.0083796205,
-0.02079858,
0.0044539724,
0.012071202,
-0.02008969,
0.022149485,
0.04651927,
-0.0064234845,
-0.0063398886,
0.005346773,
-0.1693847,
0.03196695,
0.025439806,
-0.03785208,
0.017668761,
0.008647127,
0.010064907,
0.011870572,
-0.019300546,
-0.0005968724,
0.02665696,
-0.011509439,
-0.050371353,
-0.01290047,
0.005764751,
0.00021212378,
0.013388668,
0.035872534,
0.015421713,
0.012231705,
0.03333123,
-0.0075704157,
0.019808808,
-0.004176435,
-0.012044451,
-0.018698659,
0.0036782054,
0.03236821,
0.0013350215,
0.004614476,
-0.019394174,
-0.0010750392,
0.03062942,
-0.008673877,
-0.029479146,
-0.00404937,
-0.011288747,
-0.015809596,
-0.0061827293,
0.0046947277,
0.036220293,
0.011409124,
0.0040861517,
0.009931155,
-0.009583397,
0.044191968,
0.015114081,
-0.009389455,
0.029907154,
-0.0061760414,
0.006333201,
-0.013161288,
0.018096771,
-0.0027018092,
-0.011723444,
-0.007022029,
-0.011542877,
0.008533437,
0.026469704,
-0.014766323,
-0.02198898,
-0.026777336,
0.014137684,
-0.01219158,
0.005166207,
-0.040152628,
-0.011348936,
0.0036915808,
-0.02145397,
0.008058614,
-0.004704759,
0.0038086146,
0.0052163643,
-0.005106018,
0.029184889,
-0.008794255,
-0.022737999,
0.018177023,
-0.010767111,
0.0026249012,
0.0013467248,
0.001814024,
-0.009583397,
-0.027419351,
0.009115262,
0.009342642,
0.0046044444,
0.010753735,
-0.001890932,
-0.0063298573,
0.025640436,
-0.036354046,
0.01258615,
-0.017321004,
0.0057915016,
0.016719116,
-0.01804327,
0.009442957,
-0.015929973,
-0.007242721,
0.023420138,
-0.017441383,
-0.04261368,
0.0054771826,
0.024837919,
0.017949643,
0.0035043268,
-0.007202595,
0.048177805,
-0.012659715,
-0.001949449,
-0.0036347357,
0.02466404,
0.019848935,
-0.013348542,
0.044994485,
0.011355624,
-0.01960818,
-0.009416206,
-0.008560187,
0.054678198,
-0.0026148697,
-0.008640439,
0.021213215,
0.0065338304,
-0.014231311,
-0.1231597,
0.002250393,
0.00639339,
0.022403615,
0.013575922,
0.032849718,
-0.023313135,
-0.0011686662,
0.0030980522,
0.028382372,
-0.009630211,
-0.011583003,
0.00001198421,
0.003404012,
0.042720687,
-0.000035580368,
0.01258615,
-0.023674268,
-0.011315498,
0.03929661,
0.0026014945,
-0.006654208,
-0.013629423,
0.000025274601,
0.0084197465,
0.003805271,
-0.005293272,
0.013555859,
0.018912664,
0.022938628,
-0.01713375,
-0.010887489,
0.012258456,
-0.01099449,
-0.024610538,
-0.018431153,
-0.016424859,
-0.042319424,
0.022711247,
-0.016411483,
0.004898701,
0.031699445,
0.0025262584,
-0.00669099,
0.00010888324,
-0.009864278,
-0.058209274,
0.020437447,
0.007657355,
-0.008259243,
0.0044807233,
-0.024597164,
-0.012372145,
0.0022403616,
0.0027168563,
-0.020624701,
0.020664828,
0.008961447,
-0.015488589,
0.024878044,
-0.016036976,
-0.012893782,
-0.021654598,
0.023607392,
0.024597164,
-0.018631782,
0.002666699,
-0.026362702,
0.0057915016,
-0.037798576,
-0.018698659,
-0.0022654403,
-0.03151219,
-0.01639811,
-0.013488983,
0.013161288,
-0.008045238,
-0.008192367,
0.00994453,
-0.0053434293,
-0.0007068006,
-0.013154601,
0.017601885,
-0.028676627,
0.0410354,
0.014271437,
-0.010238786,
-0.00798505,
0.018819036,
-0.029398894,
0.011094806,
0.03830684,
0.012626276,
-0.01627773,
-0.014712822,
0.012653027,
0.01761526,
-0.016959872,
0.0021584379,
0.003798583,
-0.007864672,
-0.01963493,
-0.062435865,
0.011837134,
0.0073296605,
-0.014699447,
-0.0022453773,
-0.024302907,
0.015729344,
-0.0048385123,
0.014472066,
0.028141616,
-0.019675056,
0.0116097545,
-0.01758851,
0.008346182,
-0.035043266,
-0.0054236813,
0.0071758446,
-0.011703381,
0.016625488,
0.026255699,
-0.010319038,
-0.0020280287,
0.01139575,
0.0071357186,
-0.00077869283,
-0.0077242316,
0.0050993306,
0.024543662,
-0.03836034,
-0.01892604,
0.010178598,
-0.035016518,
-0.0067946487,
0.0018976197,
-0.01551534,
-0.017374504,
-0.010606607,
0.02878363,
0.022256488,
0.016411483,
0.00809874,
-0.018712034,
0.0056309984,
0.0073831617,
-0.001380999,
0.017147126,
-0.030896926,
0.02130684,
-0.00019488219,
0.0020263568,
0.017347755,
-0.00030491487,
0.006634145,
-0.037210066,
0.0052230516,
-0.022229737,
-0.0017404599,
-0.003024488,
-0.003537765,
-0.0205177,
0.037263565,
0.030522417,
0.017601885,
-0.00066625676,
0.0054504317,
-0.00529996,
0.008961447,
-0.026095197,
0.011743507,
-0.007603854,
-0.017267503,
-0.013234852,
0.009269078,
0.033973243,
0.015207708,
0.0004313532,
0.00666424,
0.012372145,
0.0034140435,
0.019380799,
0.008901257,
0.010660108,
-0.016184105,
0.024851294,
0.029024385,
0.013789927,
-0.0103926025,
0.029452395,
-0.012318645,
0.025506683,
-0.01556884,
0.024102278,
0.0021885324,
0.00044681836,
0.0075102267,
-0.0050558606,
-0.0082525555,
0.0087541295,
0.041409906,
0.046358764,
-0.018163648,
0.010426041,
-0.017896142,
-0.017347755,
0.0087541295,
-0.00200295,
-0.00994453,
-0.008901257,
-0.019982688,
-0.0006846478,
0.020678202,
-0.003101396,
-0.002459382,
-0.00537018,
-0.021801727,
-0.018083395,
-0.019086543,
0.017481508,
-0.012178204,
0.04282769,
-0.0043068444,
0.017548384,
0.001077547,
0.03969787,
0.0071624694,
0.0037149875,
0.025292678,
-0.013020848,
0.039136108,
-0.010827299,
0.009442957,
-0.002023013,
-0.018631782,
-0.009864278,
-0.005905192,
-0.009088512,
0.020584576,
-0.005009047,
-0.017227378,
0.092664026,
0.028141616,
-0.022724623,
0.013274978,
-0.023767896,
0.01415106,
0.033010222,
0.011482689,
0.0136695495,
-0.034080245,
0.0011795337,
-0.0032017108,
-0.0038420528,
-0.030870175,
-0.033545233,
0.012599526,
0.010827299,
0.036113292,
-0.00582494,
-0.008760816,
0.0054738387,
-0.022778124,
0.04111565,
0.027793858,
0.0076506673,
-0.012659715,
0.031244684,
0.010091659,
0.008045238,
-0.024837919,
-0.009971281,
0.018685283,
-0.02628245,
-0.008767504,
0.013194726,
0.0040059,
-0.017160501,
-0.03785208,
0.027526353,
0.028248617,
-0.008767504,
0.023393387,
-0.020116441,
-0.01619748,
-0.046760023,
-0.023915023,
-0.026068445,
-0.020664828,
0.007262784
] |
BACKGROUND Results of the few cohort studies from countries with low incomes or middle incomes suggest a lower incidence of dementia than in high-income countries. We assessed incidence of dementia according to criteria from the 10/66 Dementia Research Group and Diagnostic and Statistical Manual of Mental Disorders (DSM) IV, the effect of dementia at baseline on mortality, and the independent effects of age, sex, socioeconomic position, and indicators of cognitive reserve. METHODS We did a population-based cohort study of all people aged 65 years and older living in urban sites in Cuba, the Dominican Republic, and Venezuela, and rural and urban sites in Peru, Mexico, and
|
[
0.00028945509,
-0.0011153616,
0.028898152,
-0.0516561,
-0.02341116,
0.02696464,
-0.008851039,
0.014514397,
-0.02209167,
-0.010359962,
-0.028558481,
0.03172003,
0.0151414815,
0.020824436,
-0.020641537,
0.014148598,
0.03456804,
-0.008622414,
0.03015232,
0.0034456996,
-0.030335221,
0.018407548,
0.020811373,
0.0050787325,
0.009510784,
0.0106931,
0.008086779,
-0.021752,
0.0006666857,
0.0013072429,
0.013782798,
-0.008282743,
-0.013769734,
-0.030648762,
-0.011228735,
0.0025018065,
-0.00054012565,
-0.01020319,
0.00084019545,
-0.03200745,
0.008615882,
0.00093327835,
-0.0212033,
-0.0153113175,
0.004020527,
0.027199797,
0.004402657,
-0.0068522063,
-0.014031019,
0.0045790244,
0.014671168,
0.041622747,
-0.026886255,
0.007832026,
-0.007093895,
-0.023476481,
-0.011320185,
0.022130864,
-0.009471592,
-0.010098676,
-0.0053628804,
-0.008197825,
-0.02095508,
0.013221035,
-0.024195017,
-0.025749665,
0.00148606,
0.018237712,
0.009647959,
0.026755612,
0.034123857,
0.020968143,
0.0029884505,
0.00977207,
0.044784296,
-0.0010614714,
-0.00802799,
-0.0039813346,
0.01890399,
0.005940974,
0.021856513,
-0.028244939,
-0.020027516,
0.02220925,
0.007890816,
0.011960333,
0.0026063207,
0.019923003,
0.008099844,
-0.0077013834,
-0.022156991,
0.008374193,
0.019322047,
0.02398599,
0.0017751069,
0.001308876,
0.006767289,
0.006734628,
-0.01599066,
-0.011718645,
-0.020510895,
-0.004817447,
-0.033209357,
0.00044459323,
-0.0045300336,
-0.0021539705,
-0.011424699,
-0.0013937936,
0.003264433,
-0.01945269,
-0.004363464,
0.026494328,
0.006793417,
-0.04243273,
0.0055261836,
-0.016800644,
-0.0072441343,
-0.0071134917,
0.016591616,
-0.0039813346,
0.018773347,
-0.003027643,
0.041622747,
-0.0130512,
-0.0070155095,
-0.0074531627,
-0.028349454,
-0.0076621906,
-0.008178229,
0.0021360072,
-0.032556146,
-0.0015391336,
-0.008276211,
0.01587308,
-0.024978872,
0.0006017727,
-0.0014109405,
-0.005408605,
-0.019230597,
-0.034698684,
0.017061928,
0.017884977,
-0.00940627,
-0.025632085,
0.021373136,
0.036527682,
0.027591726,
0.0066170497,
-0.00012849929,
-0.0062675807,
0.00085897534,
-0.012704996,
0.0023711638,
0.012097509,
0.005392275,
0.006590921,
0.031432617,
0.019113017,
-0.017205635,
-0.01644791,
0.003021111,
-0.022039413,
-0.026781742,
0.021738935,
-0.019727038,
0.017819656,
0.0058233957,
-0.01158147,
0.005993231,
-0.0049252277,
-0.0070873634,
0.042484988,
-0.00643415,
0.030413607,
-0.0038735543,
-0.0041675004,
0.0019498414,
0.022862462,
-0.02300617,
-0.036292527,
-0.01808094,
0.016160494,
0.012620079,
-0.004157702,
-0.01464504,
0.005447798,
0.040917274,
0.015102289,
0.0005466578,
-0.019531075,
-0.013521513,
0.007022042,
0.008733461,
-0.015180674,
-0.6509139,
-0.020184288,
-0.015245996,
-0.010915193,
0.000033834403,
0.016800644,
0.0075576766,
0.021151043,
-0.022196185,
0.034202244,
0.0056731566,
0.021542972,
-0.0027761562,
-0.005297559,
-0.010889064,
-0.013795863,
-0.009759005,
-0.005787469,
0.015677117,
0.004307941,
0.0014436012,
0.029603623,
-0.020824436,
0.021947963,
-0.013430064,
0.01694435,
0.024795974,
-0.012084444,
0.0033836444,
0.020811373,
0.0023564666,
0.021699741,
-0.004670474,
0.032765172,
0.038957637,
-0.022601176,
-0.009445462,
0.015925338,
-0.012639675,
0.020262673,
-0.0010712696,
-0.009125388,
0.010791082,
0.0054282015,
-0.012737657,
0.02439098,
-0.005898515,
0.012665804,
0.020719923,
-0.021712806,
0.005049338,
0.0077928333,
-0.022588111,
-0.014174727,
0.017231764,
0.0063590305,
-0.0031991117,
-0.04083889,
0.012737657,
0.0072637307,
0.00043642806,
-0.007387841,
-0.027931396,
-0.0028806701,
-0.040055033,
0.02493968,
-0.02616772,
0.01366522,
0.015363574,
-0.016474036,
-0.00980473,
0.019557202,
-0.01525906,
-0.020354124,
0.052753497,
-0.014031019,
0.032294862,
0.01418779,
-0.02439098,
-0.009850455,
0.007890816,
-0.013064264,
-3.986897e-8,
0.002186631,
-0.001832263,
-0.015324381,
-0.0116271945,
0.0017016204,
-0.039192792,
0.009275627,
0.0052257054,
0.014213919,
0.011411634,
-0.026402878,
0.008766121,
0.017819656,
-0.006499471,
0.007714448,
0.008387257,
-0.0041315733,
-0.02475678,
0.011653324,
0.0014035918,
0.01844674,
0.030282963,
0.024260338,
-0.028427837,
0.014710361,
0.063283294,
-0.01970091,
-0.0024136228,
0.0037494437,
0.0065484624,
-0.0015007573,
0.015102289,
-0.022065543,
0.0044189873,
-0.0049154293,
0.00090470025,
-0.01774127,
0.0021294751,
0.00058625883,
0.018760283,
-0.007825494,
0.013286357,
0.007172281,
0.008315404,
0.014958582,
-0.001928612,
-0.014057148,
0.0071004275,
0.0022013285,
0.013253695,
0.008080247,
0.027643982,
-0.010862935,
0.005245302,
-0.022013284,
-0.0047423276,
-0.026128529,
-0.021516843,
-0.0017653087,
0.017270956,
-0.020759115,
0.004209959,
-0.015833888,
-0.0056731566,
-0.007120024,
-0.029368466,
-0.0069501884,
-0.0029035327,
-0.010320769,
0.00079079624,
0.02086363,
-0.014331497,
-0.0044810427,
-0.004546364,
-0.008178229,
-0.013652156,
-0.01348232,
0.008001862,
0.014057148,
-0.019504946,
0.0132798245,
-0.020262673,
-0.026585776,
-0.008054119,
0.020053646,
0.0011553708,
-0.023633253,
-0.0111634135,
-0.004846842,
0.012313069,
0.0011529212,
0.014671168,
0.010745357,
-0.011385506,
0.010902128,
-0.0041283076,
-0.019831553,
0.018577384,
-0.0076556588,
0.0031795152,
-0.011614131,
0.04614298,
0.014266176,
0.022065543,
-0.0070416383,
0.009680619,
0.019243661,
0.01587308,
0.024456302,
0.0009708381,
0.009563041,
-0.0027369633,
0.0030766341,
-0.0034914245,
-0.012032188,
-0.009726345,
0.0069044633,
0.022771012,
-0.005490257,
0.012600482,
0.005150586,
0.021242494,
-0.007923476,
0.01890399,
-0.0024838431,
0.016212752,
0.024809036,
0.017270956,
-0.006734628,
0.0074858232,
-0.0110589,
-0.011280992,
0.03459417,
0.024142759,
-0.0059834328,
-0.028323324,
-0.003311791,
0.0014297204,
0.0013276559,
0.014906325,
0.021033464,
-0.00940627,
0.022953913,
0.018394483,
0.00953038,
0.0019188138,
-0.01464504,
-0.018485934,
0.0007642594,
0.002821881,
0.037363794,
0.0033248551,
0.027670112,
-0.010889064,
-0.019348174,
0.015846953,
0.005696019,
0.010288108,
0.014566654,
0.006679105,
-0.0015277023,
0.011143818,
-0.0081521,
0.028009782,
0.028062038,
0.001389711,
0.033235487,
0.0011063799,
0.0064014895,
-0.026860127,
-0.021347007,
-0.0076099336,
-0.004908897,
-0.0020592546,
0.008622414,
0.008661607,
0.03367967,
0.04974872,
0.009399738,
-0.0072571984,
-0.004301409,
-0.01237839,
-0.008165165,
0.009981098,
0.009641427,
0.009569573,
-0.020693794,
-0.029342337,
-0.008223955,
-0.017728206,
-0.04188403,
-0.002779422,
0.009171113,
-0.0066693067,
-0.0016575285,
0.027434954,
0.018747218,
-0.023816153,
-0.019099955,
0.013443127,
0.024913551,
-0.005549046,
-0.018512063,
0.003114194,
-0.013652156,
0.008001862,
0.006084681,
0.0018828871,
0.011999526,
-0.019073825,
0.0045006387,
0.0071918773,
0.0032056437,
0.025200965,
-0.0076948516,
-0.0038996828,
0.008256615,
0.008446047,
-0.0073682447,
-0.017035801,
-0.009367078,
0.007185345,
-0.0014378856,
-0.024704523,
0.016369523,
0.0041315733,
0.0052289716,
-0.0046900706,
-0.0031942124,
-0.020354124,
0.032451633,
0.03195519,
0.010712696,
-0.01599066,
-0.008929424,
0.02484823,
0.006038956,
0.010647375,
-0.030204577,
-0.016199687,
-0.017061928,
0.058632415,
0.0020396581,
-0.0069240597,
0.009504252,
0.033078715,
0.0088837,
0.0032742312,
-0.035378028,
0.019439625,
0.021307815,
-0.016186623,
-0.012384922,
0.043425612,
-0.001982502,
0.0058723865,
0.032216474,
-0.0011790498,
-0.021490714,
-0.0012639675,
-0.0046770065,
0.00043601982,
-0.019962195,
0.0056633586,
0.037703466,
0.034123857,
-0.019648653,
0.005486991,
0.035378028,
0.00505587,
0.014331497,
-0.011738241,
0.005950772,
0.006780353,
0.04619524,
0.010471008,
0.015023904,
0.028558481,
0.004066252,
0.021987157,
-0.012770318,
0.03300033,
-0.010190126,
0.010889064,
0.0078124297,
0.03642317,
-0.005408605,
0.003266066,
0.0149716465,
0.0048337774,
-0.01605598,
0.02892428,
0.00009236843,
0.0022993104,
-0.022143926,
0.002124576,
0.005385743,
0.018799476,
0.002475678,
-0.017479986,
-0.014409883,
-0.0095957015,
-0.02022348,
0.030335221,
-0.002186631,
-0.008798782,
0.0033068918,
-0.026037078,
0.004843576,
-0.006623582,
-0.017584499,
-0.0075315484,
-0.0014778948,
-0.029054923,
0.007871219,
-0.011810095,
0.016696129,
0.028845895,
-0.021765064,
0.0077993656,
-0.009922309,
0.009425866,
0.00909926,
0.0054151374,
-0.029760392,
0.024129696,
0.013626027,
-0.012528629,
-0.03070102,
-0.0059834328,
0.009981098,
-0.010921725,
-0.009229902,
0.023881475,
0.0015456657,
0.00723107,
-0.019687846,
0.011868884,
0.015154546,
-0.017819656,
-0.00407605,
0.013390871,
-0.036632195,
-0.006274113,
-0.014997775,
0.0019874012,
-0.022026349,
-0.03268679,
-0.0005658459,
0.010052951,
-0.022352956,
0.024534687,
-0.042302087,
0.018329162,
0.0019906673,
-0.00202986,
-0.005647028,
-0.0055229175,
0.01712725,
0.039323434,
-0.0073159877,
-0.009902712,
0.001362766,
0.033470646,
0.03655381,
-0.03349677,
0.021477649,
-0.010719229,
-0.017205635,
-0.041857902,
-0.011509617,
0.007211474,
0.040211804,
0.0036514618,
-0.03673671,
-0.015232932,
-0.0129401535,
0.0052257054,
-0.011685984,
-0.026455134,
-0.01216283,
0.0013807294,
-0.017884977,
-0.02733044,
-0.02022348,
0.03705025,
-0.03438514,
-0.0021686677,
-0.0012166096,
-0.0041217753,
0.005059136,
-0.018760283,
0.004409189,
-0.022666497,
-0.0035273512,
-0.00574501,
-0.008759589,
0.007172281,
-0.017414663,
0.025527572,
-0.0014713628,
0.017466921,
0.022339892,
-0.0055392478,
0.022392148,
0.00900781,
0.011699049,
0.016160494,
0.026468199,
0.0011463892,
0.0016534459,
0.005506587,
0.0151414815,
-0.0023303381,
-0.011862352,
0.007211474,
-0.00036824893,
0.003166451,
-0.030465864,
-0.018825604,
-0.03634478,
-0.011679452,
-0.0074531627,
-0.003801701,
-0.004699869,
-0.022379084,
0.0036090028,
0.033313874,
0.0011439396,
0.0044353176,
-0.002377696,
0.03247776,
-0.008276211,
0.017950298,
0.0035077548,
-0.033052586,
-0.029394593,
-0.008583222,
-0.016160494,
-0.009850455,
0.016617743,
-0.030387478,
0.035639312,
0.03015232,
-0.0027973854,
0.024195017,
0.010764954,
-0.027095284,
-0.014031019,
-0.008282743,
-0.0151414815,
-0.0078124297,
-0.016709194,
-0.013273292,
0.0077405763,
-0.0087073315,
0.023058426,
0.0001342149,
0.021765064,
-0.03375806,
-0.0023385033,
-0.025253221,
-0.010229318,
0.024926616,
-0.026638035,
0.021934899,
0.018498998,
-0.028584609,
-0.040055033,
0.034489658,
0.028244939,
0.0087922495,
0.047161993,
0.030622635,
-0.013952634,
-0.011176478,
0.01719257,
0.027905269,
-0.0008067183,
-0.033104844,
0.024704523,
0.03600511,
0.002475678,
-0.018956248,
-0.006793417,
-0.011725177,
0.0053171553,
-0.001661611,
-0.025592893,
0.0075838054,
-0.029054923,
0.002676541,
0.028715253,
-0.032294862,
0.014031019,
-0.012352262,
-0.0066039856,
-0.00891636,
-0.021621358,
-0.005101595,
0.022418277,
0.0067215636,
0.017074993,
-0.029002666,
-0.0011071963,
0.004056454,
-0.0009790033,
-0.0052551003,
0.0087073315,
-0.0177674,
0.030100064,
-0.016134366,
-0.03532577,
0.012084444,
-0.006773821,
-0.0128356395,
-0.012332665,
-0.0120517835,
-0.012914025,
-0.012424115,
-0.009811263,
0.011392038,
0.002820248,
-0.0033297543,
0.014044084,
-0.027356569,
-0.009752473,
-0.010921725,
-0.0057123494,
0.022483598,
0.004520235,
0.006349232,
-0.003364048,
0.0061042774,
0.032294862,
0.009948437,
0.0013211237,
0.013155714,
-0.009347481,
-0.013835056,
0.034489658,
0.024273403,
-0.012247748,
-0.003958472,
0.010052951,
-0.030047808,
-0.0070024454,
0.011679452,
-0.026677227,
-0.025801921,
-0.01970091,
-0.00864201,
-0.0007103694,
0.008929424,
-0.009837391,
0.02254892,
-0.0077405763,
0.0076425946,
0.0018028684,
-0.033444516,
0.03725928,
-0.018224647,
0.013952634,
0.0068718027,
-0.007982265,
0.009830859,
-0.0037461778,
0.01535051,
0.010653907,
-0.033130974,
0.0026063207,
-0.021268621,
0.039297305,
-0.03088392,
0.01899544,
-0.023920666,
-0.0042883446,
-0.006715032,
0.0327913,
0.00041581102,
0.0006083048,
0.009856987,
0.009961502,
-0.0003210951,
0.005493523,
0.012816043,
-0.009745941,
-0.006839142,
-0.016696129,
-0.02821881,
0.0020592546,
-0.010954386,
0.029185565,
0.018120134,
0.03200745,
-0.008047586,
-0.01896931,
-0.05591505,
-0.009667555,
0.015794694,
0.026572714,
0.0149716465,
0.020510895,
0.0032807633,
0.008851039,
0.013495385,
0.013835056,
-0.034750942,
-0.029394593,
-0.00012921373,
-0.017806591,
0.010640843,
-0.006140204,
-0.004706401,
-0.002779422,
0.033104844,
-0.023567932,
-0.021007337,
0.024795974,
0.007472759,
0.0035338835,
-0.0221178,
-0.0056698904,
-0.021360071,
-0.013730542,
-0.00011186276,
-0.02837558,
-0.0018975843,
-0.018394483,
-0.014854068,
0.004013995,
-0.015389703,
-0.013586834,
0.0018861531,
-0.0063982233,
-0.021830386,
-0.020550087,
0.023215197,
-0.027434954,
-0.0047292635,
0.0074923555,
0.012077912,
0.010248915,
0.013018539,
-0.002774523,
-0.021438457,
0.013201439,
-0.012770318,
-0.006943656,
-0.0019155476,
-0.016800644,
-0.007864687,
-0.023032296,
0.0027369633,
-0.035613183,
0.0033901765,
-0.040368576,
-0.023254389,
-0.0052191736,
0.01651323,
0.014762619,
-0.017636755,
0.010529797,
0.005486991,
-0.009164581,
-0.01872109,
-0.015794694,
0.005493523,
-0.020001387,
0.0048631723,
0.0010769853,
-0.003073368,
0.008204358,
-0.007427034,
0.0030978636,
-0.0085179005,
0.02334584,
0.18404935,
0.013547642,
-0.000063841384,
0.018224647,
-0.00931482,
0.03689348,
0.024704523,
0.0026602107,
-0.002825147,
0.020027516,
-0.02218312,
0.01127446,
-0.0064798747,
0.019099955,
0.018917054,
-0.018250776,
-0.03195519,
-0.030857792,
0.012796447,
-0.008818378,
0.0015072895,
-0.019491881,
-0.02527935,
-0.013136118,
0.029760392,
0.0070873634,
-0.0030586708,
0.0053498163,
0.023672447,
0.015193739,
0.0015407667,
-0.021347007,
-0.0045953547,
0.0025916235,
-0.020327995,
-0.026912384,
-0.015938401,
-0.026664162,
0.0031354234,
0.0049840165,
0.01899544,
0.0027679908,
-0.026376748,
-0.014279241,
0.01970091,
0.0436869,
0.013835056,
-0.01728402,
-0.009876584,
-0.010771486,
-0.05554925,
-0.013155714,
0.0017947033,
0.0019482083,
0.009765537,
0.009229902,
0.0145274615,
0.020811373,
-0.008785717,
-0.0051636505,
0.0039878665,
-0.0026814402,
-0.02564515,
0.022692626,
-0.014540526,
0.007675255,
-0.012914025,
-0.002719,
0.0055817068,
-0.005696019,
0.006228388,
-0.013136118,
-0.018864797,
-0.007668723,
0.00015054522,
-0.02625917,
0.039427947,
0.024377916,
0.013416999,
0.021451522,
-0.020523958,
0.0064635444,
-0.025880307,
0.0050232094,
-0.014854068,
-0.03545641,
0.0136390915,
0.0037527098,
-0.026128529,
0.0036481956,
-0.01908689,
-0.005800533,
-0.009517317,
-0.007361713,
0.016173558,
0.0007091446,
0.005921378,
0.0030521387,
-0.002516504,
-0.02386841,
-0.025383865,
0.087635085,
0.007890816,
0.0065027373,
0.0043797945,
0.008256615,
-0.014775682,
0.024404045,
0.009340948,
0.009981098,
0.007877751,
-0.016604679,
0.012509033,
0.0015521978,
-0.013057732,
0.026729483,
0.0068456745,
-0.017506113,
0.013560706,
-0.006404755,
-0.0036971867,
-0.034045473,
-0.006042222,
0.031119077,
-0.013626027,
-0.010673503,
-0.018708026,
-0.014671168,
-0.025788857,
-0.0130250715,
-0.0043863268,
-0.050663214,
-0.002975386,
-0.014253112,
-0.013900377,
-0.008400322,
0.025671279,
-0.0053269537,
-0.005251834,
0.017297085,
0.0021082456,
-0.03723315,
0.029603623,
-0.011450827,
0.012548226,
-0.0023874943,
0.0034326355,
0.0022437873,
-0.017858848,
-0.014331497,
-0.028898152,
-0.0015228032,
0.014788747,
-0.0040335916,
0.022431342,
-0.031876802,
-0.016095173,
-0.020968143,
-0.031223591,
0.027225927,
-0.018485934,
0.014122469,
0.035195127,
-0.0070612347,
-0.0035306173,
0.026494328,
-0.16429618,
0.030596506,
0.009915777,
-0.021085722,
0.028950408,
-0.00034518234,
0.012914025,
-0.009994162,
0.005486991,
-0.005291027,
0.008139037,
0.0020429243,
-0.018668832,
-0.01348232,
0.001062288,
0.009334416,
-0.0149716465,
0.024247274,
0.02785301,
0.027095284,
0.02261424,
-0.031197462,
-0.0025491645,
-0.021673614,
0.014893261,
0.008544029,
0.015664052,
0.015455024,
-0.020811373,
-0.021451522,
-0.0052746967,
-0.016683064,
0.039610848,
-0.018956248,
-0.022287635,
0.010764954,
-0.030309092,
-0.019713974,
-0.0068522063,
-0.011431231,
0.008400322,
0.041152433,
0.007074299,
-0.001609354,
0.010177062,
0.02172587,
0.024560817,
-0.053119298,
0.003114194,
0.002777789,
0.015376639,
-0.025135644,
0.022588111,
-0.0012982612,
-0.014488269,
-0.001982502,
-0.00046745568,
0.009347481,
0.020706858,
-0.00022699159,
-0.012567822,
-0.020824436,
0.016578551,
0.021738935,
0.008530964,
-0.027304312,
-0.0036906546,
-0.007120024,
-0.00297212,
0.0047782543,
-0.035874467,
-0.014592783,
0.0017636756,
-0.012456776,
0.017519178,
0.018786412,
-0.0018926852,
-0.023228262,
-0.017558372,
-0.0108041465,
-0.011431231,
0.009393206,
-0.033183232,
-0.015089225,
-0.022196185,
-0.0041511697,
0.02086363,
0.009060067,
0.005085265,
-0.023580996,
0.004938292,
-0.025135644,
0.031171333,
-0.002273182,
0.008655075,
0.044078827,
-0.026912384,
0.017297085,
-0.0051603843,
-0.012006058,
-0.004415721,
0.0065974533,
-0.037834108,
0.012149765,
0.029159438,
0.0044614463,
-0.015363574,
-0.001732648,
0.009628363,
-0.002367898,
0.016487101,
0.020550087,
0.009902712,
0.0031909465,
0.0034261032,
0.0068522063,
-0.02389454,
-0.010849871,
-0.0013031603,
0.023293583,
0.052727368,
-0.011437763,
0.0073813093,
-0.00317135,
0.012090976,
-0.007511952,
-0.11538358,
0.0026112197,
-0.0066954354,
0.021647485,
0.011359378,
0.016265009,
-0.015206804,
0.019674782,
-0.018877862,
0.02022348,
-0.0012639675,
-0.010307704,
-0.0034032408,
-0.005042806,
0.037363794,
-0.034123857,
-0.006581123,
-0.019491881,
-0.030047808,
0.038644094,
-0.004321005,
-0.020654602,
0.021856513,
-0.01801562,
-0.001457482,
-0.014501333,
-0.004405923,
0.01908689,
0.0042752805,
0.018512063,
-0.015886145,
-0.0121367015,
0.00079569535,
0.013521513,
0.0019090156,
-0.016474036,
0.010092144,
-0.011411634,
0.045646537,
-0.011679452,
0.0014427847,
0.012332665,
0.0048631723,
0.001291729,
0.008184762,
-0.0085179005,
-0.027121412,
-0.0024413844,
-0.00035824662,
-0.0028529086,
-0.009086195,
-0.014854068,
-0.012678868,
-0.0066660405,
0.004415721,
-0.0072506666,
0.0012304904,
0.012300004,
-0.01393957,
-0.014253112,
0.00024434255,
0.0065549943,
-0.024809036,
0.012397987,
0.021347007,
-0.03195519,
-0.041126303,
-0.029760392,
-0.013821991,
-0.020732988,
-0.014422948,
0.012280408,
-0.009092728,
-0.0029949825,
-0.020484766,
0.02874138,
-0.0022846132,
0.003560012,
0.0062055252,
-0.011117688,
-0.016839836,
-0.008361129,
0.005114659,
-0.010621247,
0.013978763,
0.018603511,
0.007884284,
0.0040466557,
0.0049186954,
-0.011927673,
0.008145569,
0.028349454,
-0.01154881,
-0.005438,
0.0064570126,
0.02058928,
0.011463892,
-0.02245747,
0.02245747,
-0.0012949952,
-0.006878335,
-0.014409883,
-0.04972259,
0.014318434,
0.0016967213,
-0.023110682,
-0.00025209947,
-0.0015342345,
0.008870635,
-0.010222786,
-0.009393206,
0.015768567,
-0.037572823,
0.012829107,
-0.011463892,
0.009536913,
-0.029603623,
-0.0212033,
0.020811373,
0.012032188,
0.040211804,
0.035168998,
-0.003458764,
0.022627305,
-0.00031252168,
0.043164328,
-0.016526293,
-0.008622414,
-0.008237018,
0.01544196,
0.0013823624,
-0.0038702881,
0.009549977,
-0.016016787,
0.0036971867,
0.0012753988,
0.0073682447,
-0.016487101,
0.009732877,
0.013305953,
0.034959972,
0.04334723,
-0.019727038,
-0.033940956,
-0.00084019545,
-0.040917274,
-0.027931396,
-0.012123637,
-0.018773347,
0.009536913,
0.0014533993,
-0.01856432,
0.027173668,
-0.001979236,
-0.0067215636,
-0.014566654,
-0.019909939,
0.0037821045,
-0.0032203412,
0.013861184,
-0.014213919,
-0.025671279,
0.008459111,
0.011496552,
0.005046072,
0.01100011,
0.012678868,
-0.016291138,
-0.0049709524,
0.023032296,
-0.015820824,
-0.006675839,
-0.020602344,
-0.006976317,
-0.0036351315,
0.0050134114,
-0.003811499,
-0.016774515,
-0.006045488,
0.00058258453,
0.003221974,
0.0039748023,
0.015376639,
0.018381419,
-0.01764982,
0.022771012,
0.017061928,
0.024809036,
-0.010503668,
0.024129696,
-0.0008324386,
-0.0045235013,
-0.004157702,
0.014932454,
-0.0031599188,
0.009856987,
-0.007962669,
-0.0010116639,
-0.007133088,
0.017506113,
0.024704523,
0.007910412,
0.00015993517,
-0.008615882,
-0.018054813,
-0.0424066,
-0.009249499,
-0.00002407448,
-0.021686679,
-0.015363574,
-0.01393957,
0.02527935,
0.018603511,
0.037389923,
-0.0083480645,
-0.004102179,
0.005696019,
0.0006695435,
-0.0108237425,
0.014122469,
-0.0087726535,
0.008439515,
-0.004752126,
0.02200022,
0.014697297,
0.009001277,
0.018368356,
-0.006447214,
0.0111830095,
-0.008197825,
0.021752,
-0.0013227568,
0.008870635,
-0.010412218,
-0.022431342,
-0.007982265,
-0.012783382,
-0.036841225,
0.020563152,
0.007211474,
0.0075054197,
0.06877028,
0.0031256252,
-0.0039094808,
0.006443948,
-0.010399154,
-0.0074596945,
-0.012313069,
0.010059483,
-0.0041740322,
-0.009843923,
0.019191403,
-0.005477193,
0.024116632,
-0.016382586,
-0.00821089,
0.0054184035,
0.001877988,
0.02298004,
0.0028774042,
-0.020367188,
0.018368356,
-0.022784077,
0.025697406,
-0.0039258115,
-0.020327995,
0.0055196513,
0.018067878,
-0.013096925,
-0.012672336,
-0.025579829,
0.00034171215,
0.0032317722,
-0.028088167,
0.0068522063,
0.0005291027,
-0.015703246,
0.0027908534,
-0.016003724,
-0.0154158315,
-0.020458637,
-0.008204358,
0.000036334983,
-0.018498998,
-0.014671168,
-0.008361129,
-0.026089335,
-0.0153113175,
-0.03890538,
-0.0064962055
] |
Extracellular vesicles, including exosomes, are small membrane vesicles derived from multivesicular bodies or from the plasma membrane. Most, if not all, cell types release extracellular vesicles, which then enter the bodily fluids. These vesicles contain a subset of proteins, lipids and nucleic acids that are derived from the parent cell. It is thought that extracellular vesicles have important roles in intercellular communication, both locally and systemically, as they transfer their contents, including proteins, lipids and RNAs, between cells. Extracellular vesicles are involved in numerous physiological processes, and vesicles from both
|
[
-0.024060013,
0.0042014667,
-0.0019184117,
-0.029171474,
-0.025428232,
0.00007790018,
-0.003005888,
-0.008822435,
-0.012862555,
-0.0060343645,
0.007905986,
0.013462764,
-0.031623945,
-0.0004953342,
-0.0017844939,
0.00056108297,
0.017657777,
-0.0065603545,
0.0022298107,
-0.005914968,
-0.01758033,
0.0076220157,
-0.0083319405,
-0.010971572,
0.0075962003,
0.02248527,
0.007809178,
-0.012417238,
0.010777956,
-0.025428232,
-0.005066285,
0.012378515,
-0.012094544,
-0.006505497,
0.0041724243,
0.017335083,
0.0049178456,
-0.010061577,
0.012133268,
0.016973667,
0.025040999,
0.015244031,
-0.021839881,
-0.0018877558,
-0.0036690228,
-0.009041866,
-0.031210896,
-0.008312579,
0.011300719,
0.0021297757,
0.039652552,
0.0046564643,
-0.00058528496,
-0.0058020256,
-0.032062806,
-0.0011052245,
-0.02509263,
0.01951649,
0.016638067,
-0.023259733,
-0.0033463296,
0.0033592372,
-0.019942446,
-0.0011052245,
-0.011842844,
0.035754416,
0.0039239503,
0.013837089,
-0.0007780942,
0.01712856,
0.012352699,
0.010197108,
-0.006266704,
0.0051146885,
0.018871104,
-0.0278807,
-0.02333718,
0.0022991898,
-0.033611733,
0.001705434,
-0.015321477,
-0.0044079903,
-0.0043079555,
0.022678886,
0.013669288,
0.02116868,
0.015889417,
0.0042046937,
0.004333771,
-0.010235831,
0.013294964,
0.008499742,
-0.004033666,
0.011100649,
-0.0097001605,
0.015528002,
0.007867263,
0.02697716,
0.0020975063,
-0.022201298,
0.0032850178,
0.030178277,
-0.043215085,
-0.019335782,
-0.034954138,
0.015631264,
0.00008359773,
-0.018057916,
0.022149667,
-0.0013916148,
-0.027364392,
0.03159813,
0.00964853,
-0.02948126,
0.018535502,
0.010932849,
0.035547893,
-0.011165188,
-0.015850695,
-0.01616048,
0.008938604,
0.0176965,
0.019671382,
-0.025634754,
0.021065418,
-0.0018199902,
-0.003420549,
0.0025750925,
0.0055987285,
0.011449158,
-0.0071121603,
0.004140155,
-0.015618356,
0.011339443,
-0.021530097,
-0.0073315916,
-0.018535502,
0.011371711,
0.01547637,
-0.010545617,
0.01816118,
0.022885408,
-0.014972969,
0.017012391,
-0.015334385,
0.034128044,
0.042827856,
0.022227114,
0.024060013,
0.01649608,
0.04842981,
-0.018470963,
0.008461018,
-0.021607542,
-0.010823133,
0.024834476,
-0.0070863445,
0.022098036,
0.005592275,
-0.010603702,
-0.023492072,
0.019077627,
0.02544114,
-0.0005691503,
0.034128044,
0.02679645,
-0.009583991,
0.00824804,
0.0051275967,
0.007557477,
-0.032837268,
0.021117048,
-0.036683775,
0.014779353,
-0.01337241,
0.024718307,
0.013282056,
0.021104142,
-0.031649757,
-0.037148453,
-0.002881651,
0.025931634,
0.032837268,
-0.010765049,
-0.0027122372,
-0.0024266536,
0.025286246,
-0.038490858,
0.031339973,
-0.016805867,
-0.013862904,
0.002041035,
-0.025376601,
-0.023646964,
-0.6315495,
-0.03812944,
0.008441657,
-0.00788017,
-0.0035915764,
0.021814067,
0.0059956415,
0.008699811,
-0.015037508,
0.00836421,
-0.03141742,
0.020665279,
0.021801159,
-0.012430145,
-0.0057987985,
-0.034618538,
-0.024047105,
-0.019645568,
0.03916206,
-0.016573528,
-0.036967743,
0.009958315,
-0.0034463643,
0.026486665,
0.0029671649,
0.00933229,
-0.00036161818,
-0.017257638,
-0.029042397,
0.0148567995,
-0.016663881,
0.002525075,
-0.01871621,
0.012727023,
0.040065598,
0.012694755,
0.0005243766,
0.035083216,
0.011984829,
0.02362115,
-0.006750744,
-0.016715514,
-0.0037238805,
0.020574924,
-0.03159813,
0.008054425,
0.009325836,
0.0047371374,
-0.006315108,
-0.017154375,
0.012798016,
0.0018458057,
-0.026228512,
0.001551348,
-0.019645568,
0.003849731,
0.024189088,
0.00080753997,
0.0037335614,
0.0025863869,
0.009061228,
0.02509263,
-0.005727806,
-0.015114954,
-0.0029994342,
0.0049436614,
-0.018225716,
0.004343452,
0.015244031,
0.0009842146,
0.001463414,
0.03198536,
0.010681148,
0.021491373,
0.0036464343,
0.023827672,
0.0059536914,
0.0028235663,
-0.018057916,
0.016121756,
0.018006286,
-0.013979074,
-0.029352183,
-0.0012092931,
0.03807781,
0.002697716,
-0.014121058,
0.028216302,
0.02128485,
0.01849678,
0.009583991,
0.017064022,
0.0051405043,
-0.04951406,
-0.035134844,
0.010532709,
-0.0088159805,
0.0055567785,
0.0011907383,
0.0043466785,
0.005789118,
-0.008544918,
0.0078479005,
-0.000065950444,
0.00009322811,
-0.0064086886,
-0.04233736,
0.00080068276,
0.030591324,
-0.03528974,
0.023814766,
0.0034399105,
0.013785457,
-0.002860676,
-0.0325533,
-0.018238625,
0.008441657,
0.01118455,
0.011494335,
-0.055038568,
-0.002095893,
-0.013720918,
-0.010339093,
0.008028609,
0.014185597,
0.012255891,
-0.002652539,
-0.03624491,
-0.036916114,
-0.016095942,
-0.010435902,
0.0054470627,
0.0056955367,
-0.0030720402,
0.025634754,
0.007060529,
0.02298867,
0.012623762,
-0.01672842,
-0.04866215,
0.004275686,
-0.015489278,
0.012623762,
-0.023763135,
-0.011178096,
-0.007938255,
0.002576706,
-0.01215263,
0.005188908,
-0.010358455,
0.008880519,
-0.010687602,
0.0012141336,
-0.0016312146,
0.02497646,
-0.011023203,
-0.014121058,
-0.030204093,
0.0021943145,
-0.0011165187,
-0.012107452,
0.0040013967,
-0.010009946,
0.010145477,
0.007912439,
-0.0150246,
-0.0094613675,
0.006069861,
0.0155796325,
-0.03647725,
0.017670685,
0.0013391771,
-0.012100998,
0.01030037,
-0.005388978,
0.010894125,
0.01632828,
0.0037819655,
-0.001757065,
-0.0155796325,
0.004817811,
-0.04809421,
-0.01021647,
0.006008549,
0.029997569,
0.021129956,
0.043163456,
0.008306125,
0.00731223,
0.009028958,
-0.010177746,
-0.003105923,
-0.013198156,
0.013133617,
0.01861295,
-0.027519284,
0.0018425788,
0.02071691,
0.020368401,
0.024498874,
0.01644445,
-0.010597248,
-0.0022120625,
-0.015811972,
0.005004973,
-0.02128485,
-0.015321477,
-0.0009277432,
-0.009028958,
0.028422825,
0.023646964,
0.014469568,
-0.017670685,
-0.0063893273,
-0.017257638,
0.004627422,
0.010861856,
-0.0046145143,
-0.027235314,
-0.030720402,
-0.007925347,
-0.018819474,
0.010242285,
-0.015631264,
-0.027725808,
0.010313278,
0.0023395263,
0.029507075,
-0.02981686,
-0.019245429,
0.028009778,
0.0040627085,
0.020678187,
-0.00048807362,
0.025028093,
-0.007867263,
0.015218216,
-0.02572511,
0.018367702,
-0.0031704616,
-0.015166584,
0.02076854,
0.008106056,
0.011849298,
0.007563931,
-0.015902326,
0.015941048,
0.011513697,
-0.0025670251,
-0.009364559,
-0.0066216663,
-0.004604833,
-0.028551903,
-0.0030946287,
-0.005340574,
-0.021801159,
0.012023552,
0.017051114,
0.041356374,
0.004030439,
0.012301069,
-0.0223691,
-0.004975931,
-0.0006143274,
0.009429098,
0.0034334566,
0.009661437,
-0.017851394,
-0.007518754,
0.0047403644,
-0.016870406,
-0.019077627,
-0.001950681,
-0.009358105,
0.025028093,
0.042750407,
-0.0075123,
0.0015465076,
0.022498177,
0.022717608,
-0.035780232,
-0.009777606,
-0.0012512433,
0.004378948,
-0.013043263,
-0.016741328,
-0.044764012,
0.016121756,
-0.006305427,
0.0076220157,
0.0104294475,
0.021775344,
-0.008054425,
-0.0038271425,
-0.00674429,
0.026396312,
0.024679583,
0.014585737,
0.032114435,
-0.012894824,
0.003202731,
0.008086694,
-0.018432241,
-0.005305078,
0.043008562,
0.017064022,
0.009822784,
0.0068927286,
0.012088091,
-0.016070126,
-0.03665796,
-0.01126845,
-0.0024702172,
-0.026925528,
-0.0026364042,
0.0039304043,
0.0044499408,
0.0072928686,
0.03601257,
-0.0062344344,
-0.014805168,
-0.025234615,
-0.02134939,
-0.026021987,
0.026267234,
0.009738884,
-0.0038787734,
0.024395613,
0.003054292,
-0.010577886,
-0.024718307,
0.00436604,
0.0064990427,
-0.014405029,
0.007751093,
-0.02389221,
0.0032124117,
-0.010958664,
-0.003126898,
0.029119844,
-0.023776041,
-0.0049468884,
-0.0046919603,
-0.020019893,
0.011281357,
-0.026667373,
0.022098036,
0.015205308,
0.017218914,
-0.001297227,
-0.007893078,
0.021710806,
0.003952993,
0.001506171,
-0.0022394916,
0.0061505344,
0.0029316687,
-0.0024492422,
-0.034850877,
-0.019374505,
-0.003002661,
0.019013088,
0.0014658343,
0.04871378,
0.018070824,
0.031727206,
-0.00075066526,
-0.024111643,
-0.012636669,
-0.017593239,
-0.007402584,
0.0029865263,
0.022394914,
-0.0123591535,
0.025454046,
-0.0070540756,
0.0028332472,
-0.036838666,
0.014972969,
-0.0015884577,
0.0149342455,
0.0010334253,
-0.016431542,
-0.024821568,
-0.0010777956,
0.019400321,
-0.004514479,
-0.012668938,
0.003662569,
-0.021388112,
-0.008467472,
-0.008822435,
-0.014585737,
-0.003801327,
-0.0006538573,
-0.032914717,
-0.011494335,
-0.013436949,
0.007783362,
0.029558705,
0.009764699,
-0.02082017,
0.02038131,
0.039110426,
-0.0029929804,
-0.0005066285,
-0.0068991827,
-0.03732916,
-0.012778655,
0.009041866,
-0.010958664,
0.011823482,
-0.005789118,
-0.023995474,
0.0055600055,
-0.019710107,
0.010926395,
0.0033366487,
-0.00093661726,
0.020678187,
0.032527484,
0.006050499,
-0.0035367184,
-0.0016336348,
-0.005298624,
-0.017489977,
0.0006841098,
-0.022007683,
0.0047306838,
-0.0044983444,
-0.019077627,
0.004033666,
-0.0088998815,
0.006976629,
-0.002742893,
-0.010861856,
-0.0058956067,
-0.021426834,
-0.013875811,
0.025053907,
0.0076413774,
0.0018974366,
-0.005259901,
-0.0056051826,
-0.0048403996,
-0.01838061,
0.0065861703,
-0.01587651,
-0.0024686037,
0.030746218,
0.011629866,
-0.0139661655,
-0.0035367184,
-0.000031386964,
0.016379911,
0.029584521,
-0.014766445,
-0.011746036,
-0.01934869,
-0.0014222707,
0.03580605,
0.0084158415,
-0.0038271425,
-0.011326535,
0.015386016,
0.019129258,
-0.0018361248,
0.0015707096,
-0.0023120975,
-0.039239503,
0.0071444297,
0.022227114,
-0.0012189739,
0.012714116,
-0.0021749528,
0.0009898617,
-0.043395795,
-0.036167465,
-0.007073437,
-0.037638947,
-0.01826444,
-0.0006175543,
0.040168863,
0.028009778,
-0.0027800028,
-0.0011979989,
0.040194675,
0.0021701124,
0.017064022,
0.016057217,
0.021775344,
-0.007454215,
-0.012707662,
0.014882615,
0.015669987,
0.0021943145,
0.019284151,
-0.016405728,
0.0028090451,
0.020833079,
0.009293566,
-0.012242984,
0.0020152195,
-0.02452469,
-0.0030833345,
0.016250834,
0.011720221,
0.011888021,
-0.030229907,
-0.0073896763,
-0.012171991,
0.013462764,
-0.0059052873,
-0.021943145,
0.02151719,
-0.03126253,
0.023285547,
-0.013056171,
-0.023130655,
-0.0026880351,
-0.003649661,
-0.018638765,
-0.007318684,
0.01570871,
0.008099602,
-0.0076284693,
0.030358985,
0.01223653,
-0.012662485,
-0.008125417,
-0.02679645,
-0.0045015714,
-0.010526256,
-0.007854355,
-0.028706795,
-0.0026993295,
-0.012165537,
-0.065364756,
0.004624195,
0.01445666,
-0.0028477684,
0.024950646,
-0.007699462,
0.00066676503,
0.016483173,
-0.011236181,
-0.00030837377,
-0.02082017,
0.027157867,
0.03386989,
0.000375736,
-0.023517888,
-0.006492589,
0.0031656213,
0.006789467,
0.0404012,
0.017657777,
-0.0007736572,
-0.000061009203,
0.0028413145,
0.002884878,
-0.011765397,
-0.038800642,
0.021465559,
-0.00436604,
-0.0037174267,
-0.017257638,
-0.013566026,
-0.015953956,
0.014701907,
-0.017477069,
-0.0044370326,
0.016625158,
0.0032834043,
-0.0028445413,
0.03549626,
0.0014989104,
0.0322177,
0.012849647,
-0.0037303346,
-0.020110246,
-0.013643472,
-0.012042914,
-0.013824181,
-0.007854355,
0.0075510233,
0.00031704616,
-0.008467472,
0.029042397,
0.027338576,
0.011997737,
-0.003988489,
0.017064022,
0.03743242,
-0.024034197,
-0.0029236013,
0.031830467,
0.020587832,
-0.009919592,
-0.013798365,
-0.011371711,
-0.001566676,
-0.03425712,
-0.023608241,
0.033431027,
0.008957966,
-0.0044467137,
-0.029068211,
-0.009861507,
-0.007815632,
-0.0479135,
-0.023208102,
0.004579018,
-0.022459453,
-0.020794356,
-0.014443751,
0.015928142,
0.038490858,
-0.012378515,
-0.0022039951,
-0.025918726,
0.02555731,
0.00076034607,
0.019142166,
-0.0035883493,
-0.004759726,
-0.020058615,
0.002836474,
-0.0018845288,
-0.032088622,
-0.0038077808,
-0.022640161,
-0.03590931,
-0.015218216,
-0.011675043,
0.035831865,
0.007505846,
-0.016883314,
0.01564417,
-0.021710806,
0.01348858,
-0.008035063,
-0.005524509,
0.03170139,
-0.021052511,
-0.0073767686,
-0.0014150101,
-0.025363693,
-0.027751623,
0.037251715,
-0.007867263,
-0.018277349,
0.005879472,
-0.011371711,
-0.011997737,
-0.007234784,
0.008151232,
-0.012875463,
-0.0024234266,
-0.00913222,
-0.010881218,
-0.009577537,
-0.0031188307,
-0.014637368,
-0.016702605,
0.0063473773,
0.03936858,
0.015553817,
-0.014921338,
0.0009075749,
-0.032630745,
-0.02697716,
0.0049727038,
0.014701907,
0.0020862122,
0.032191884,
0.0063280156,
-0.0048952573,
-0.0016408954,
0.010648878,
-0.062008742,
-0.0069637215,
0.004624195,
0.011332989,
0.010222924,
0.023079025,
0.0069830827,
-0.006360285,
0.01021647,
0.011681497,
-0.009196759,
-0.03203699,
0.017761039,
-0.01166859,
0.017761039,
0.008525557,
-0.04700996,
0.003943312,
0.036632143,
-0.003112377,
-0.005443836,
0.020394215,
-0.004478983,
0.024253627,
-0.0068088286,
0.019826276,
-0.0069120903,
0.015140769,
0.02589291,
-0.03632236,
-0.013798365,
-0.0010850562,
-0.009790515,
-0.015437648,
0.00045782112,
0.0019200251,
0.013075532,
0.011545966,
0.024821568,
-0.0064538657,
0.007073437,
-0.00456611,
0.0025863869,
0.015127862,
-0.011746036,
0.015321477,
0.009035412,
0.0062796115,
-0.00811251,
0.0043950826,
-0.0089773275,
0.002313711,
-0.007970524,
0.019116351,
-0.015489278,
-0.0027993643,
-0.014495383,
-0.038568303,
0.0071121603,
0.008170594,
0.030926926,
-0.013294964,
0.016934944,
0.011003842,
-0.033172872,
-0.020290954,
-0.00074098445,
-0.007957617,
-0.019116351,
-0.005143731,
0.0024944192,
-0.012849647,
0.0049275267,
-0.005443836,
-0.0009705001,
-0.007673647,
-0.00071678247,
-0.018019194,
-0.013746735,
-0.00941619,
0.17523536,
-0.036038388,
0.021026695,
0.03658051,
-0.01288837,
-0.0223691,
-0.0010043829,
-0.0018103094,
0.02338881,
0.0006586977,
0.011558874,
0.015889417,
-0.015360201,
0.004272459,
0.02265307,
-0.022278745,
-0.03407641,
0.0068991827,
0.0015529615,
0.014753537,
-0.029429628,
-0.022343284,
0.010926395,
-0.011061926,
0.022201298,
-0.012443054,
-0.01354021,
0.005192135,
-0.011261996,
0.007738185,
-0.012301069,
-0.017683592,
0.0037432422,
0.0025040999,
0.02868098,
0.015373109,
0.01656062,
0.0073832227,
0.014960061,
0.022911225,
0.02782907,
-0.0100228535,
-0.013630564,
-0.009713069,
-0.005240539,
0.0026961025,
-0.012210715,
-0.013695103,
-0.003701292,
-0.028293747,
-0.050443415,
0.024189088,
-0.012301069,
0.01838061,
0.00020975064,
0.015282755,
0.01405652,
0.033147056,
0.011197457,
0.01980046,
-0.008725626,
0.017180191,
-0.022394914,
0.03226933,
-0.010442355,
0.021439742,
-0.006511951,
-0.038723197,
0.029971752,
-0.012701208,
0.0003733158,
0.022201298,
-0.011997737,
-0.010597248,
-0.0015335999,
-0.010932849,
0.014921338,
0.009074136,
-0.0056987638,
0.024989368,
0.0013593455,
0.0038755464,
-0.053644534,
0.0039788084,
-0.015941048,
-0.045202877,
0.016638067,
-0.0035560802,
-0.022214206,
-0.009725976,
0.015824879,
-0.017993378,
-0.011481428,
0.0006147307,
0.03170139,
0.006247342,
0.0074219457,
0.00027146575,
-0.024214905,
-0.014972969,
-0.033998966,
0.08255785,
0.04120148,
0.0004047784,
0.0017151148,
0.002555731,
-0.032579117,
0.004230509,
0.008299671,
-0.014637368,
0.0036819305,
-0.017025298,
-0.004330544,
-0.02442143,
0.0002886088,
0.008919243,
0.012701208,
-0.024485968,
0.06345441,
-0.020355493,
-0.019426137,
-0.006486135,
0.025312062,
0.0036270726,
0.017554516,
0.032682378,
-0.016741328,
0.033431027,
0.0027574142,
-0.016650975,
0.004630649,
0.009364559,
-0.004191786,
-0.013862904,
0.023169378,
-0.02617688,
0.0034721799,
0.010306824,
-0.005782664,
-0.0076284693,
-0.011171642,
0.0062763845,
0.018703304,
0.034695983,
-0.000015731299,
0.004011078,
0.03492832,
0.015928142,
-0.0038335964,
-0.015528002,
-0.029945938,
-0.024111643,
0.0035012222,
-0.026615743,
0.033198684,
-0.031056004,
-0.015618356,
-0.016625158,
-0.020691095,
-0.0037658308,
-0.035005767,
-0.003985262,
0.006211846,
-0.027674178,
-0.00074461475,
0.0021281622,
-0.1594363,
0.0051146885,
-0.002158818,
0.0017602919,
0.01894855,
-0.0017925613,
-0.010113208,
0.0027380525,
-0.0075123,
-0.007899532,
0.036554698,
-0.0059472374,
-0.033714995,
-0.035083216,
-0.0033915066,
0.005911741,
0.024950646,
0.027132053,
0.026538296,
0.007964071,
0.03916206,
-0.011178096,
0.01849678,
-0.021710806,
0.030436432,
0.009067682,
0.0076284693,
-0.0069959904,
-0.013643472,
-0.009880869,
0.029068211,
-0.016805867,
0.027983962,
-0.013307871,
0.018522596,
0.013785457,
-0.0008022962,
-0.002510554,
0.018367702,
0.014753537,
0.015721617,
0.017941747,
-0.031882096,
0.018006286,
-0.006315108,
-0.010597248,
-0.035599526,
-0.018522596,
0.0012343018,
-0.016922036,
0.0011584689,
0.0047694067,
-0.014792261,
0.010229377,
0.0022717607,
0.010106754,
0.0069830827,
0.025750926,
0.03203699,
-0.012739931,
-0.019451952,
0.008751442,
0.024615044,
-0.001753838,
0.018019194,
-0.016379911,
-0.0052147238,
0.013036809,
-0.025363693,
0.0030284766,
-0.024318166,
-0.014818076,
0.004427352,
-0.007822085,
0.011733128,
0.02026514,
-0.014469568,
0.031649757,
-0.012927094,
-0.0046790526,
-0.029713599,
0.016792959,
-0.0052502197,
-0.03237259,
-0.011126465,
-0.016044311,
-0.010222924,
0.009106405,
-0.002234651,
0.003510903,
0.0020313542,
-0.023169378,
0.0102616465,
0.0069056363,
0.023698596,
0.027777439,
0.0023701822,
-0.012765747,
-0.005043696,
0.009158036,
0.017851394,
-0.00031220575,
0.0026622196,
0.001357732,
0.0075962003,
-0.009371013,
-0.0059504644,
-0.0012697981,
0.047139037,
-0.03652888,
-0.031649757,
-0.013578934,
0.0070540756,
0.03676122,
0.015489278,
0.02464086,
0.02225293,
-0.0044983444,
0.0357286,
-0.023156472,
0.05348964,
-0.008106056,
-0.00027388593,
0.026925528,
0.0034270028,
-0.023091933,
-0.12742513,
-0.007905986,
-0.005395432,
0.028577719,
0.003202731,
0.004669372,
0.0035915764,
0.034050595,
0.013043263,
0.038542487,
-0.02190442,
0.016044311,
0.014960061,
-0.019529399,
0.014676091,
-0.0046887337,
0.004537068,
-0.0061860303,
-0.05514183,
0.013043263,
0.006886275,
-0.003991716,
-0.011933198,
0.004466075,
0.016431542,
0.021555912,
-0.029223105,
0.03954929,
0.02617688,
-0.003946539,
0.020807264,
0.008719173,
0.004362813,
-0.027390206,
0.001046333,
0.0063893273,
0.005385751,
-0.026112342,
0.02333718,
-0.011662136,
-0.002739666,
0.016199203,
0.0019813369,
-0.022059314,
0.012991632,
-0.03363755,
-0.028242117,
-0.010448809,
0.004475756,
-0.0116363205,
-0.049436614,
-0.017154375,
-0.046519466,
-0.024176182,
0.0035463993,
-0.008099602,
-0.035831865,
0.020303862,
-0.017180191,
-0.018806566,
-0.0068023745,
0.012978724,
-0.0018119229,
-0.0016941398,
0.0071121603,
-0.03647725,
0.00008500952,
-0.0101842005,
0.018561319,
-0.03278564,
0.0082544945,
0.008538465,
-0.0006958074,
0.0100228535,
-0.020368401,
0.015850695,
0.007060529,
0.0030042746,
-0.005821387,
-0.018225716,
-0.007989886,
-0.019335782,
0.00022830551,
-0.0018199902,
0.02265307,
0.017967563,
0.014753537,
0.007279961,
-0.0063893273,
-0.015979772,
-0.006989537,
0.029042397,
0.005879472,
-0.0572587,
0.007918893,
-0.009087043,
-0.0065151774,
0.011294265,
0.02566057,
0.019038904,
-0.012578584,
-0.00055785605,
-0.046751805,
0.0056471326,
0.006047272,
-0.004540295,
0.012146176,
-0.038568303,
0.0018700076,
-0.02862935,
0.006705567,
0.032837268,
-0.006679751,
0.012952909,
-0.0024234266,
-0.005004973,
-0.017309269,
-0.0005393012,
0.02475703,
-0.018238625,
-0.007208968,
0.02749347,
-0.0018813019,
-0.0065280856,
0.01764487,
0.00010487532,
-0.007170245,
0.023362994,
-0.0015763567,
0.029042397,
-0.020742726,
-0.035883494,
-0.016315373,
-0.041975945,
-0.000731707,
0.008538465,
-0.0049920655,
0.003985262,
-0.008157686,
0.014650276,
0.009887323,
0.017283453,
-0.019439043,
-0.058136422,
0.01564417,
0.0050759655,
-0.024886107,
0.010113208,
-0.004098205,
0.017167283,
-0.01838061,
-0.0066281203,
0.03482506,
0.023285547,
-0.009771153,
-0.041020773,
-0.00040094642,
0.02901658,
0.0032285464,
-0.008964419,
-0.009809876,
-0.019206705,
0.032914717,
0.029068211,
0.0056987638,
0.0073380456,
-0.009435552,
-0.0063861003,
-0.022614347,
-0.0022072222,
0.021865698,
-0.0055955015,
-0.003891681,
0.0005074352,
0.0074219457,
-0.0017005936,
0.00788017,
-0.000792212,
-0.0062763845,
0.021891514,
-0.00961626,
0.014237228,
0.013030355,
0.0142114125,
-0.0061247186,
0.009254844,
0.038490858,
0.0079318015,
-0.024331074,
0.020807264,
-0.0029381225,
0.016896222,
-0.022459453,
0.019864999,
-0.0012697981,
0.005982734,
-0.0024879654,
0.0029348955,
-0.005914968,
0.011926744,
0.0128431935,
0.013759642,
-0.0034721799,
0.015489278,
-0.0036012572,
-0.027261129,
0.002981686,
0.0014069427,
-0.040168863,
-0.03859412,
-0.017115653,
0.013256241,
0.0003844084,
-0.010442355,
0.011578236,
-0.009855053,
-0.022859594,
0.016083034,
0.028035594,
0.004388629,
-0.0038271425,
0.028190486,
0.012836739,
0.031959545,
0.0032850178,
0.0045951526,
-0.0006106971,
0.006886275,
0.008506196,
-0.0011261996,
0.012023552,
-0.009325836,
-0.008757896,
-0.03118508,
-0.011746036,
0.0058568832,
-0.0064280503,
-0.005682629,
-0.0018813019,
0.005814933,
-0.02088471,
0.054522257,
0.011881568,
0.009338744,
0.0146115525,
0.001397262,
0.036064204,
0.017025298,
0.02156882,
-0.007938255,
-0.025983265,
0.009125766,
-0.0032462946,
0.03676122,
-0.0225369,
-0.00061190716,
0.023350086,
0.0085707335,
0.021917328,
-0.017683592,
-0.004798449,
0.012455961,
-0.00771237,
0.024666676,
0.0058568832,
-0.020665279,
0.012869009,
0.041175663,
-0.00017264091,
-0.0021733392,
-0.012830285,
0.014172689,
0.000375736,
-0.04466075,
-0.012094544,
0.0031075364,
-0.007473577,
-0.009642076,
-0.032114435,
0.005537417,
0.019025996,
-0.00019764964,
-0.0023943842,
-0.018535502,
-0.0013343368,
-0.01741253,
-0.022046406,
-0.02071691,
0.007409038,
-0.029945938
] |
OBJECTIVES To provide direct estimates of risk of cancer after protracted low doses of ionising radiation and to strengthen the scientific basis of radiation protection standards for environmental, occupational, and medical diagnostic exposures. DESIGN Multinational retrospective cohort study of cancer mortality. SETTING Cohorts of workers in the nuclear industry in 15 countries. PARTICIPANTS 407 391 workers individually monitored for external radiation with a total follow-up of 5.2 million person years. MAIN OUTCOME MEASUREMENTS Estimates of excess relative risks per sievert (Sv) of radiation dose for mortality from cancers other than leukaemia and from leukaemia
|
[
0.0046882257,
-0.016851014,
0.015560919,
-0.038117602,
-0.03317003,
0.019870097,
-0.0062808925,
-0.0110522425,
-0.010054748,
0.021545889,
-0.01549442,
0.014284126,
0.0060880436,
0.030297244,
-0.016930813,
0.016997311,
0.038117602,
-0.008458756,
0.01762241,
-0.0035311317,
-0.018340604,
0.009090503,
-0.028249053,
0.009496151,
0.008086358,
-0.0003476685,
0.014137827,
-0.039660394,
0.013073833,
-0.0020598269,
0.014071327,
0.0030207469,
-0.0023457753,
-0.022676382,
-0.011956638,
0.010353996,
-0.0051670233,
0.008791255,
0.02135969,
-0.0193248,
-0.0069226143,
0.014643224,
-0.0048810747,
0.000004857592,
0.00014235082,
0.0030207469,
0.0090772025,
-0.02123999,
0.0068295146,
0.0082725575,
0.016026417,
0.004847825,
-0.016837712,
0.003098884,
-0.008944204,
-0.027584057,
-0.005572671,
0.018194307,
-0.0032052833,
-0.021519288,
-0.0031504212,
-0.0027414483,
-0.035138417,
0.025961466,
-0.023367979,
-0.01173054,
-0.0044056023,
0.0058785696,
-0.018114505,
0.020375494,
0.033941425,
0.026280664,
-0.00041603847,
0.0074280114,
0.031201638,
0.0028611477,
-0.014869323,
-0.0020448645,
0.014284126,
-0.007933409,
0.009502801,
-0.029871644,
0.003677431,
0.01339968,
0.016611613,
0.013206831,
-0.020721292,
0.03098884,
0.0058951946,
0.0012053063,
0.02324828,
0.0017156911,
0.0016358915,
0.0037871555,
0.0016965724,
0.02310198,
0.0064537916,
0.033569027,
-0.007966659,
-0.054689318,
-0.021851787,
-0.018699704,
-0.007999908,
-0.0036807558,
-0.029685447,
-0.0009567638,
-0.0011978251,
0.008851104,
0.036973808,
-0.024564972,
-0.0193514,
0.030430242,
-0.00783366,
-0.014111227,
0.021984786,
-0.020694694,
0.03668121,
0.011417991,
0.008738055,
-0.024525072,
0.015840217,
-0.00766741,
0.033489227,
-0.028648052,
0.024139374,
-0.0034147573,
-0.033569027,
-0.014164426,
0.0194711,
-0.012176087,
-0.025815167,
-0.016957412,
0.01577372,
-0.010846094,
-0.016545115,
0.021838486,
0.008678205,
-0.012335686,
-0.021998087,
-0.031840034,
0.019497698,
-0.007308312,
-0.0034081074,
-0.014310726,
-0.0007597586,
0.025256569,
0.014403826,
0.011105442,
-0.016864313,
-0.0135326795,
-0.008059759,
-0.028062854,
0.009043953,
-0.0028711227,
-0.006929264,
-0.014044727,
-0.0061345934,
0.02896725,
-0.021958185,
-0.028727852,
0.0053232973,
0.00973555,
-0.010746344,
0.019377999,
-0.007474561,
0.024072876,
0.008285857,
0.00084288314,
0.010068048,
-0.0033100203,
0.0039766794,
0.046017762,
-0.019018902,
0.04101699,
-0.026546663,
0.022476884,
-0.025655568,
0.025682166,
-0.022463584,
-0.021266589,
-0.038357,
0.0115576405,
0.022476884,
0.0053399224,
-0.020016396,
0.009329902,
0.026599862,
0.019511,
-0.018806102,
-0.003674106,
-0.0025402869,
0.011670689,
-0.0073149623,
-0.026879162,
-0.64903665,
-0.030616442,
-0.00957595,
-0.006942564,
0.00788686,
0.031095238,
-0.0024272373,
-0.00081004895,
-0.022796081,
0.045432564,
0.00032688736,
0.018194307,
0.022264084,
-0.03686741,
-0.028461853,
-0.029499248,
-0.024897471,
0.014244226,
0.026559962,
-0.0059517194,
-0.03277103,
0.035590615,
-0.024511773,
0.016372215,
-0.006749715,
0.0192051,
0.019524299,
-0.025296468,
0.032052834,
0.0056624454,
-0.023447778,
-0.0026782737,
0.012428786,
0.018726302,
0.04628376,
-0.029366247,
0.014177727,
0.022530083,
0.008026509,
0.022024686,
-0.021665588,
0.009057253,
0.02493737,
-0.013200182,
-0.040910587,
0.010506946,
0.020162696,
0.01707711,
0.037346207,
-0.016465316,
0.012382236,
0.00769401,
-0.014377225,
0.0011595878,
0.026187565,
-0.013067182,
0.014523525,
-0.014377225,
-0.021811888,
0.013107082,
-0.0018187655,
0.0052667726,
-0.01361913,
0.007933409,
-0.018792802,
0.024764473,
-0.004658301,
0.011145342,
0.0017572534,
-0.03082924,
0.031600635,
0.030244043,
0.013778728,
-0.008957503,
0.038755998,
0.008445457,
0.006334092,
0.0005935094,
-0.008292507,
0.003647506,
0.0025968116,
-0.007228513,
-0.03457982,
0.027397858,
-0.0025352994,
-0.023647277,
-0.018380504,
0.00769401,
0.029313048,
0.010520246,
-0.018673103,
0.0067297653,
0.0034347072,
-0.01351938,
-0.009449601,
0.028328853,
0.005589296,
0.0009866887,
-0.009176953,
-0.044235572,
-0.039022,
-0.012388886,
0.0003270952,
0.0039700293,
-0.00005164114,
-0.005017399,
-0.02120009,
-0.00022402071,
0.030456843,
-0.029286448,
0.015826918,
0.0011255067,
0.005396447,
0.0074479613,
-0.0036175812,
-0.023075381,
0.019963197,
0.010234297,
-0.020774493,
-0.01157759,
0.027876657,
0.022117786,
0.027504258,
0.0012352311,
0.008844454,
0.018513504,
0.002091414,
0.0041030287,
0.008126258,
-0.029419448,
0.010447096,
-0.0021629012,
0.017210111,
-0.013426281,
0.021479389,
-0.008033158,
-0.0015793669,
-0.011384741,
-0.010879343,
-0.00033769355,
-0.043863174,
0.002104714,
0.00670649,
-0.010220997,
0.0015976542,
-0.013938328,
0.004977499,
0.026240764,
0.011411341,
-0.0023640627,
-0.005938419,
-0.023407878,
-0.008179458,
0.01731651,
0.01147784,
0.00770731,
-0.0068960143,
-0.032478433,
-0.01161749,
-0.00764081,
0.01361913,
0.011125392,
-0.0050373487,
-0.0015236733,
-0.0045585516,
-0.014018128,
-0.012488635,
0.010320746,
0.012215987,
-0.034420222,
0.0019384649,
-0.009057253,
-0.004036529,
0.01730321,
0.020481894,
0.016917512,
0.0054496466,
-0.006756365,
-0.008718105,
-0.024804372,
0.0025668866,
-0.008126258,
-0.016186016,
0.002137964,
0.0384102,
0.024658073,
0.00774721,
-0.011910088,
-0.007148713,
0.022543384,
-0.0089375535,
0.023806877,
-0.0074147116,
0.025469368,
0.0004638351,
-0.0037738555,
0.008758005,
-0.006975814,
0.03215923,
0.023886677,
0.018034706,
-0.0032834206,
0.037426006,
0.011238442,
0.012368936,
0.011351491,
0.013160282,
0.0015760418,
0.016970713,
-0.0063906168,
0.014310726,
0.0007368993,
-0.012275836,
0.0035278068,
-0.014310726,
0.02682596,
0.0024139376,
0.002689911,
-0.010533545,
-0.008472056,
-0.005233523,
-0.015787018,
0.029791845,
-0.0055394215,
-0.009728899,
0.0033299702,
0.0037505806,
-0.0123622855,
0.007155363,
0.005343247,
-0.012229287,
0.0035145069,
0.006038169,
0.0003054828,
0.014935822,
0.018500203,
-0.0044887266,
-0.012322386,
0.02138629,
0.022782782,
-0.0057123206,
-0.003285083,
0.004275928,
0.008166158,
0.011331541,
-0.02298228,
0.023700478,
0.010546845,
-0.018061306,
0.00013206416,
-0.0101079475,
0.02503047,
-0.0389422,
0.0097555,
0.0018570028,
-0.006330767,
0.0103007965,
0.021798586,
0.021811888,
0.022809383,
0.04375677,
-0.0026832612,
0.025828466,
0.011198542,
-0.0013141994,
0.007986609,
-0.015906718,
0.0010124573,
-0.0004916818,
-0.0067397403,
-0.009110453,
-0.031414438,
-0.008984104,
-0.022224184,
0.009196903,
0.009828649,
0.0053665224,
0.014470325,
0.016944112,
0.013233432,
-0.031653836,
-0.010533545,
0.022609882,
0.026107764,
-0.007940059,
-0.01726331,
0.0013707242,
-0.01736971,
-0.010686494,
-0.0038004552,
0.035989612,
0.0061345934,
-0.03332963,
0.00079425523,
-0.0010772945,
-0.007394762,
-0.0027963105,
-0.021904986,
-0.010141198,
-0.00667989,
0.008106308,
-0.020854292,
0.02493737,
-0.0193514,
0.012980733,
0.01740961,
0.0019700523,
-0.018885903,
-0.0196174,
-0.0005876907,
-0.017835207,
-0.014643224,
0.0003549419,
-0.012521885,
0.012861033,
-0.005233523,
-0.0067663398,
-0.020335594,
0.009349852,
-0.010693145,
-0.017848508,
-0.028701251,
-0.010154498,
-0.016930813,
0.02925985,
0.025376268,
-0.0041329535,
0.009941698,
0.0087979045,
-0.0096757,
-0.006174493,
-0.027171759,
0.01363243,
0.020136096,
0.0027763606,
0.04476757,
0.013991527,
0.02113359,
0.0075876107,
0.025881667,
0.016518515,
-0.023953175,
-0.013698929,
-0.0083257565,
-0.0030057845,
0.009509451,
0.03702701,
0.061605282,
0.013426281,
-0.008644955,
0.014882623,
0.02505707,
0.010187747,
-0.009409701,
0.00030091094,
0.024897471,
-0.0051570483,
0.026879162,
-0.005070599,
-0.020561693,
0.03154744,
0.0028711227,
-0.001532817,
-0.0012210999,
0.02679936,
-0.0020581644,
0.0035643815,
0.012215987,
0.022357184,
-0.0194312,
-0.010187747,
0.029712046,
0.00092018896,
-0.010447096,
0.016877612,
-0.007228513,
-0.010852744,
-0.031308036,
-0.0024621498,
-0.010713095,
0.01730321,
-0.020202596,
-0.024259074,
0.0073615117,
-0.002919335,
-0.006201093,
0.009948349,
0.0016200979,
-0.03098884,
-0.018500203,
-0.024631472,
0.0078004096,
-0.007102163,
0.0063374173,
0.0030623092,
-0.02491077,
-0.028541652,
0.018859303,
0.011005693,
-0.0022609883,
0.026280664,
-0.013778728,
-0.028275654,
-0.004063129,
-0.019883396,
0.01747611,
-0.0151752215,
-0.015720518,
-0.006131268,
0.03253163,
-0.004033204,
-0.006357367,
-0.026187565,
0.024791071,
0.01707711,
-0.014949122,
0.008751355,
-0.009901798,
0.006975814,
0.007374812,
-0.0060148938,
0.011916738,
-0.00778711,
-0.005030699,
0.005393122,
-0.025722066,
-0.014696424,
-0.00969565,
0.012568435,
-0.018048007,
-0.0194312,
0.0055593713,
0.0053498973,
0.003474607,
0.010254247,
-0.03298383,
0.0192982,
-0.001157094,
0.008711454,
0.018061306,
0.015055522,
0.017901707,
0.016132817,
0.0066133905,
0.002709861,
0.013240081,
0.014324026,
-0.009303302,
-0.0090240035,
-0.001958415,
-0.0005049818,
-0.028089454,
-0.018872602,
-0.010952493,
0.011417991,
0.018965703,
-0.010939193,
-0.032185834,
-0.0011745502,
-0.018500203,
0.0068827146,
0.005788795,
0.0013233431,
-0.027451057,
0.0031653836,
0.011351491,
-0.012196037,
0.0098818485,
0.031361237,
-0.024179274,
-0.004462127,
0.019165201,
-0.0041795033,
-0.0019151901,
-0.009875199,
-0.005795445,
-0.008877704,
0.008146208,
-0.018194307,
-0.02517677,
-0.006171168,
-0.008472056,
0.048970345,
0.003102209,
0.027823456,
0.008212707,
-0.005396447,
0.00579212,
0.0064770663,
0.016624914,
0.007368162,
0.012741334,
0.00003634102,
0.012947483,
-0.0003094312,
-0.0076807104,
-0.005087224,
-0.026307264,
0.0062775677,
0.018659804,
-0.001420599,
-0.024192575,
-0.0007838647,
-0.033994623,
-0.0193647,
0.010360646,
-0.006523616,
0.015082122,
-0.006929264,
-0.014962423,
0.004801275,
-0.014031427,
-0.0122226365,
-0.0033549077,
0.00077388977,
-0.020308996,
-0.016372215,
-0.022144385,
0.0035411066,
-0.020601593,
-0.0069226143,
-0.012009838,
-0.015201821,
0.0064205416,
0.000075903125,
0.023979776,
0.01557422,
-0.0190322,
0.005077249,
-0.010187747,
-0.025495969,
-0.010746344,
-0.015906718,
-0.01160419,
-0.007940059,
0.010380596,
-0.00062010926,
-0.006304167,
0.0016982349,
0.0024106125,
0.0005793783,
0.014643224,
-0.005755545,
-0.025469368,
-0.0047248006,
-0.020308996,
0.044075973,
-0.021758687,
0.0386762,
0.017742109,
0.00085618306,
-0.030164244,
0.00069076516,
0.010766294,
0.015920017,
0.02495067,
0.016744614,
-0.02723826,
-0.020441994,
-0.014363926,
0.018659804,
-0.015933318,
-0.031574037,
0.023700478,
-0.00385698,
-0.0021612388,
-0.01167734,
-0.0041662036,
-0.019750398,
0.018752903,
0.022809383,
-0.022104485,
0.008711454,
-0.022264084,
0.0008204395,
0.031786837,
-0.02299558,
0.021971487,
0.0032002958,
-0.022463584,
-0.002601799,
-0.018274106,
-0.021732088,
0.006380642,
-0.01542792,
0.044900566,
0.0015760418,
-0.010792894,
0.0055427463,
-0.012807834,
0.013186881,
0.0005419722,
-0.028568253,
0.035191618,
-0.0025618991,
-0.014683124,
-0.004575176,
-0.0037672054,
0.0027480982,
-0.0020448645,
-0.027318059,
-0.0020814391,
-0.031520836,
0.007846959,
0.026639761,
0.0095693,
-0.012043088,
-0.007940059,
-0.01349278,
-0.008758005,
0.0037605555,
-0.014124527,
-0.0004987474,
-0.026413662,
-0.0070556137,
0.002520337,
0.017635709,
0.017981507,
0.01160419,
-0.009190252,
0.008784604,
0.0020481893,
-0.023407878,
0.018526804,
0.020428695,
0.023660578,
-0.011856888,
0.016970713,
-0.0193115,
-0.007175313,
-0.008226007,
-0.0037040308,
-0.049156547,
-0.04819895,
-0.029738646,
0.000007883846,
0.020029696,
-0.038170803,
0.025708767,
0.0074812113,
0.010154498,
-0.012209337,
-0.02690576,
0.04242678,
-0.0013998178,
0.008492006,
0.018340604,
-0.015122022,
0.018606603,
-0.02896725,
-0.0047647003,
-0.012648234,
-0.0062576174,
-0.00773391,
-0.010201047,
0.008777955,
-0.021545889,
0.004199453,
-0.029685447,
-0.0063906168,
-0.010234297,
0.008678205,
0.003860305,
-0.0041063535,
0.013645729,
-0.033835024,
0.0015710543,
-0.0018869278,
-0.020668093,
-0.02131979,
-0.0005232692,
-0.010334047,
-0.014935822,
-0.0048976997,
-0.005353222,
0.029818445,
0.032850828,
0.01548112,
-0.014762923,
-0.016412115,
-0.060966883,
-0.008977453,
-0.001738966,
0.021439489,
0.013273331,
0.043889772,
0.013659029,
0.024578273,
-0.008804554,
0.01545452,
-0.020601593,
-0.038117602,
0.013925028,
-0.0035677066,
0.026839262,
-0.0053299475,
-0.04428877,
0.0037539057,
0.028621452,
0.0056657707,
-0.009183602,
0.031893235,
-0.019856798,
-0.00022069573,
-0.00679959,
0.0125019355,
-0.019989796,
0.0021895012,
-0.021851787,
-0.021771988,
-0.0039268048,
0.015999816,
-0.0028445227,
-0.020162696,
-0.0026616487,
0.019936597,
0.01744951,
-0.00044139146,
-0.007574311,
-0.02098729,
0.021492688,
-0.033489227,
-0.006975814,
0.028302254,
0.019670598,
0.026147665,
0.0115576405,
-0.013792029,
-0.0039268048,
-0.012987383,
-0.016066317,
-0.014882623,
0.00019295291,
-0.0095493505,
0.017795308,
0.012801183,
0.0028395352,
-0.02109369,
0.00020947392,
-0.020481894,
-0.014284126,
-0.012388886,
0.03290403,
0.0023042131,
-0.02682596,
-0.0043856525,
0.008066408,
-0.005572671,
-0.009017353,
-0.019417899,
0.01744951,
-0.040006194,
-0.00490435,
-0.004126304,
0.007135413,
-0.0047447504,
-0.0026333863,
-0.014669824,
-0.008904303,
0.02098729,
0.18375185,
-0.010826144,
0.0002632971,
0.018127806,
-0.02314188,
0.006796265,
0.033702027,
0.0048578,
-0.0073881117,
0.045512363,
0.004428877,
0.015959917,
0.0070423135,
0.009004054,
0.025522567,
0.0057056705,
-0.02722496,
0.0035976314,
-0.005575996,
0.035909813,
0.014191027,
0.0033100203,
-0.0033066953,
-0.015747119,
0.007354862,
0.022144385,
-0.019856798,
0.011151992,
0.03295723,
0.006350717,
0.00082833634,
-0.009954998,
0.012156137,
-0.001255181,
-0.0017439534,
-0.010600045,
-0.00006940901,
-0.035643816,
-0.013127032,
-0.0031986334,
0.005396447,
-0.0194046,
-0.031627238,
-0.024392074,
0.011863539,
0.026214164,
-0.0023657253,
-0.022264084,
-0.011770439,
-0.0123622855,
-0.04013919,
0.01157094,
0.0065934407,
-0.014071327,
0.005379822,
0.0039234795,
0.039846595,
-0.011763789,
-0.010872694,
0.0055693462,
0.007142063,
-0.010353996,
-0.02508367,
0.012182737,
-0.027823456,
0.02722496,
-0.010247597,
-0.005423047,
-0.013326531,
0.004960874,
0.0016142791,
-0.005060624,
-0.026599862,
0.0043457523,
-0.011976588,
-0.0051204734,
0.022636482,
0.029180048,
0.022264084,
0.0083257565,
-0.0033549077,
-0.012987383,
-0.03104204,
0.02689246,
-0.008206057,
-0.015028922,
0.010486996,
0.021120291,
-0.009117103,
0.018114505,
-0.0095693,
-0.00049001933,
-0.015986517,
-0.003311683,
0.010114597,
-0.0064105666,
0.0004310009,
0.0019966522,
-0.02146609,
-0.022769483,
-0.026041266,
0.08692835,
0.0059616943,
0.020894192,
-0.004412252,
0.0011462878,
-0.026839262,
0.039553996,
-0.004635026,
-0.0008545206,
0.0016907537,
-0.014856023,
0.017010612,
-0.014643224,
-0.0004079338,
0.007368162,
-0.007082213,
-0.028009655,
0.018659804,
-0.0057123206,
0.024019675,
-0.038091004,
0.004309178,
0.009190252,
-0.013173582,
-0.02883425,
-0.03689401,
-0.0019634024,
-0.013911728,
-0.019963197,
0.007913459,
-0.021811888,
0.015015623,
-0.0024405373,
0.014443725,
0.00004878373,
-0.009123753,
-0.0012368936,
0.001603473,
0.00037509963,
0.005226873,
-0.02516347,
0.009489501,
0.010174448,
-0.002141289,
0.0054795714,
0.020734593,
0.024086175,
-0.013366431,
0.0049342746,
-0.018593304,
-0.011537691,
-0.0020116146,
-0.022383785,
0.00009060578,
-0.029392848,
-0.0058153947,
-0.052348528,
0.0019501024,
0.01732981,
-0.01718351,
-0.00079259276,
0.026466863,
-0.025575768,
-0.023527578,
0.0059051695,
-0.16885592,
0.008053108,
0.024737872,
-0.022742882,
0.0193913,
0.0049641994,
0.013951628,
0.01758251,
0.0011662378,
-0.0011645752,
0.033382826,
0.0021230015,
-0.056551307,
-0.027530858,
0.0022643132,
0.0061445683,
0.0013582555,
0.049076747,
0.023899976,
0.0195775,
0.019550899,
0.010413846,
-0.000017118466,
-0.0038968797,
-0.00083872693,
0.020801092,
-0.009176953,
-0.0014737986,
-0.005948394,
0.005592621,
-0.016172716,
0.004289228,
0.022131085,
-0.004099704,
-0.012674835,
0.008099658,
-0.009309952,
-0.004684901,
-0.006955864,
-0.00037925586,
0.015787018,
0.031095238,
-0.0029293098,
0.009908449,
-0.012515235,
0.026653063,
0.033648826,
-0.02679936,
0.015946617,
-0.011404691,
0.02318178,
-0.022277385,
-0.00965575,
-0.00479795,
-0.010493645,
0.0062077427,
0.012009838,
0.011078843,
0.021612387,
0.014629925,
-0.02513687,
-0.035776816,
0.015015623,
-0.016092917,
-0.01541462,
-0.043304577,
-0.01577372,
-0.007521111,
-0.014324026,
0.0010540196,
-0.023673877,
-0.0022992257,
0.014882623,
-0.010959143,
0.03082924,
0.012302436,
-0.00953605,
-0.006909314,
-0.011830289,
-0.008259257,
0.0053465725,
0.020814393,
-0.0026732862,
0.0035710316,
-0.01542792,
-0.0023125254,
0.0036441812,
0.016239217,
-0.005442997,
-0.00008218942,
0.017595809,
-0.022264084,
0.006955864,
-0.029499248,
0.0017988157,
0.01731651,
0.012708084,
0.006769665,
0.008112958,
-0.017595809,
0.010068048,
-0.020840991,
-0.030483441,
0.012621635,
0.024165975,
-0.011211842,
-0.013260031,
0.0029392848,
0.023953175,
-0.0191918,
-0.0114711905,
-0.0037805054,
0.0051503982,
0.0016018105,
-0.0027431108,
-0.0015710543,
-0.006586791,
-0.005955044,
-0.018008107,
-0.017569209,
0.045592163,
-0.005655796,
-0.014470325,
0.005014074,
0.0028894101,
-0.01151109,
-0.10772944,
-0.019909997,
0.0083257565,
0.020375494,
0.006004919,
0.03261143,
0.00060597813,
-0.010726394,
0.0013166931,
0.024804372,
-0.003308358,
-0.0091304025,
-0.027903255,
0.0064770663,
0.027796855,
-0.01538802,
0.008764654,
-0.045459166,
-0.015241721,
0.02298228,
0.00012790793,
-0.018181005,
0.005213573,
-0.0006109656,
-0.0017273285,
0.009290002,
-0.019417899,
0.011883489,
0.009469551,
0.006506991,
0.011883489,
-0.003687406,
-0.012355636,
-0.008492006,
-0.023913275,
-0.0051005236,
-0.026839262,
-0.032398634,
0.018939102,
-0.02125329,
0.011863539,
0.029499248,
0.018872602,
-0.004073104,
-0.0026234114,
-0.02312858,
-0.02522997,
0.01359918,
0.01728991,
-0.015866818,
-0.019005602,
-0.041203186,
-0.0054795714,
0.0059051695,
0.0017954907,
-0.02504377,
0.0011911751,
0.008365656,
-0.021998087,
0.008146208,
0.00776716,
0.018393805,
-0.016718013,
0.014709724,
0.022264084,
-0.02701216,
-0.024126075,
-0.014616624,
0.0032335457,
-0.023514278,
-0.016944112,
-0.012375586,
-0.016664814,
0.010014848,
-0.02499057,
-0.011092142,
-0.02883425,
-0.0039401045,
-0.0014638237,
-0.021825187,
-0.0073814616,
-0.01537472,
0.021971487,
-0.0076275105,
0.032052834,
0.02122669,
0.013127032,
-0.0098087,
0.00052077544,
0.00033499202,
0.013645729,
0.034420222,
0.0011288316,
-0.03261143,
0.014284126,
0.022769483,
-0.005270098,
-0.0070689134,
0.010520246,
0.010360646,
-0.032132633,
-0.015042222,
-0.06261607,
0.018646503,
0.0148959225,
-0.008372307,
0.008039808,
-0.014696424,
0.02703876,
-0.0135858795,
0.0040398543,
0.02127989,
-0.0143373255,
0.018673103,
-0.025509268,
0.01359253,
-0.0033416077,
-0.016146116,
-0.010240947,
0.02689246,
0.039261397,
0.021865087,
-0.0021845137,
0.0075543607,
0.023793576,
0.021000592,
-0.0028328854,
0.0064571165,
0.020069595,
0.020588294,
-0.0193248,
-0.010919243,
0.029978044,
-0.015813619,
-0.016332315,
-0.004046504,
0.0067397403,
-0.029100249,
0.0019933272,
0.021878386,
0.018433705,
0.014523525,
-0.019497698,
-0.011271692,
-0.0058918693,
0.006450467,
-0.011324891,
0.0043856525,
-0.019511,
0.014603324,
-0.0009185265,
0.016890913,
0.018659804,
-0.004073104,
0.0047214758,
-0.015707219,
-0.012541835,
0.019045502,
0.011763789,
0.026333863,
-0.012754634,
-0.012588385,
0.030004645,
0.008059759,
0.0062376675,
-0.004585151,
0.0039700293,
-0.022117786,
-0.010739694,
-0.015614119,
0.006121293,
-0.015893418,
-0.024285674,
0.0022909131,
0.01528162,
0.016851014,
-0.00040294635,
-0.023115281,
-0.023328079,
-0.008019858,
-0.012315736,
0.010786244,
0.0081861075,
0.009057253,
0.0025702117,
0.009183602,
0.033728626,
0.03473942,
-0.018792802,
0.016385514,
0.014377225,
0.0032086084,
-0.0013831928,
0.018287405,
0.008651605,
-0.0030323842,
-0.0022077886,
0.027850056,
0.026200864,
0.004674926,
0.018181005,
0.023540879,
0.011836939,
-0.0017938282,
-0.005828695,
-0.027477657,
-0.012688134,
0.013805329,
-0.019511,
-0.022689683,
-0.016970713,
0.02915345,
0.031228239,
0.025402868,
0.009383101,
0.010267546,
-0.023607377,
0.0021778636,
0.018500203,
0.0041562286,
-0.0032119334,
0.031680435,
-0.002503712,
0.018992301,
0.018513504,
-0.006989114,
0.034473423,
0.0047248006,
-0.00034288884,
-0.023115281,
0.038463403,
-0.0072484626,
0.00783366,
-0.011404691,
-0.029499248,
0.0014222614,
0.0008125427,
-0.029791845,
0.012601685,
0.0017206786,
-0.020814393,
0.082778774,
-0.0016533476,
-0.014523525,
-0.0074812113,
-0.01147784,
0.023301478,
0.026373763,
0.00045427578,
0.013925028,
-0.059530493,
0.008917604,
-0.008146208,
0.021572487,
-0.029313048,
-0.01730321,
0.02102719,
0.016784513,
0.017422909,
-0.015840217,
-0.02295568,
0.009196903,
-0.012807834,
0.017649008,
0.008844454,
-0.02686586,
-0.020069595,
0.0148959225,
-0.00292266,
0.006915964,
-0.026466863,
-0.00966905,
-0.0014322363,
-0.012654885,
-0.011171943,
0.018274106,
-0.019989796,
-0.0012834433,
-0.041256387,
0.00680624,
-0.001823753,
0.0060880436,
0.020415394,
-0.0031603961,
-0.01528162,
-0.030643042,
-0.0007522774,
-0.027371258,
-0.01538802,
0.012654885
] |
The multifunctional signaling protein p75 neurotrophin receptor (p75(NTR)) is a central regulator and major contributor to the highly invasive nature of malignant gliomas. Here, we show that neurotrophin-dependent regulated intramembrane proteolysis (RIP) of p75(NTR) is required for p75(NTR)-mediated glioma invasion, and identify a previously unnamed process for targeted glioma therapy. Expression of cleavage-resistant chimeras of p75(NTR) or treatment of animals bearing p75(NTR)-positive intracranial tumors with clinically applicable gamma-secretase inhibitors resulted
|
[
-0.03330545,
-0.009616746,
0.010404558,
-0.017997442,
-0.00090921036,
0.011212746,
-0.018011024,
0.013032864,
-0.0390103,
-0.012849494,
0.035125572,
0.013596557,
0.0003854169,
0.0050358875,
-0.012903825,
-0.005334713,
0.03474525,
0.0050257007,
-0.008095453,
0.016041493,
-0.010017443,
0.021406768,
0.007457053,
-0.027084451,
0.0074638445,
0.014968438,
-0.0076607973,
-0.040341433,
0.009419792,
-0.025291499,
0.008468985,
0.011158413,
-0.016639143,
0.0030425861,
0.004655564,
-0.01073055,
0.018255517,
-0.00995632,
0.0014380974,
0.020211466,
0.009283963,
-0.009161716,
0.003922084,
0.0024704034,
-0.008305989,
0.0023617398,
-0.008061496,
-0.016557645,
-0.018038189,
0.0214611,
0.01136895,
-0.00963712,
-0.014384369,
-0.012503128,
-0.013460727,
-0.024150528,
0.008394278,
0.020129967,
0.023512129,
-0.019029748,
-0.0018303058,
-0.012292592,
-0.030860517,
0.025957065,
0.015240097,
0.028687242,
-0.0058984067,
0.0140583785,
0.020170717,
-0.0009983486,
0.038983136,
0.03393027,
-0.006030841,
-0.0034466798,
0.021148691,
-0.026133642,
-0.029257726,
0.00036525467,
-0.023783788,
-0.004006977,
0.020849865,
-0.024367856,
-0.009127758,
0.0118715195,
0.018228352,
-0.004754041,
-0.013440353,
0.015729085,
0.0137595525,
-0.009942737,
0.000056984823,
0.009657495,
-0.00794604,
0.011396116,
-0.01183077,
0.016856471,
-0.009929154,
0.018880334,
0.0073959297,
-0.025495242,
-0.00082304335,
0.018459262,
-0.014791859,
-0.01927424,
-0.006557181,
-0.0010968251,
0.0022581695,
-0.0036504243,
0.028578578,
-0.007328015,
-0.008251657,
0.015769834,
-0.020320129,
-0.026595464,
0.03284363,
0.011307826,
0.048708547,
0.030425861,
0.00040897485,
-0.013712012,
0.022126665,
-0.017956693,
0.02287373,
-0.02123019,
0.029475054,
0.0390918,
0.016774973,
0.0089443885,
-0.013474311,
-0.0037013604,
0.0086116055,
0.010098942,
0.011301034,
0.0066217,
-0.005721828,
-0.012156762,
-0.012863076,
-0.016122991,
-0.03183849,
-0.025658239,
0.021406768,
0.031132177,
-0.012034515,
-0.00076658913,
-0.017250378,
0.01726396,
0.015362344,
0.014452284,
0.018635841,
0.01927424,
-0.004709896,
-0.02228966,
0.012183928,
-0.014153459,
-0.010771299,
0.008142993,
-0.00039815094,
0.02370229,
-0.014805442,
-0.019029748,
-0.0031970926,
-0.0010229677,
0.011063333,
0.014560948,
0.03553306,
0.02849708,
0.000781021,
0.011891894,
0.009107384,
-0.006475683,
0.006563972,
0.028035259,
-0.040069774,
0.016870053,
-0.023512129,
-0.015905663,
0.012469171,
0.020768367,
-0.022167414,
-0.0021681823,
-0.01945082,
0.007280474,
0.011334992,
-0.0058848234,
-0.002358344,
0.006655657,
0.037298847,
-0.022928061,
0.006210815,
-0.027980927,
0.0041631814,
0.0035417606,
-0.0016630654,
-0.027980927,
-0.6259034,
-0.031186508,
0.031593997,
0.00945375,
0.012625375,
0.053218093,
0.013209443,
-0.014927689,
-0.011790021,
0.01749487,
-0.011681357,
0.032300312,
-0.011362158,
-0.02963805,
-0.016978718,
-0.02287373,
-0.031947155,
-0.02095853,
0.016313152,
-0.0132434,
-0.025060587,
0.005589394,
-0.011654192,
0.025372995,
0.008292406,
0.032327477,
0.018866751,
-0.02105361,
-0.022235328,
0.018486427,
-0.026962204,
0.017617118,
-0.021895755,
-0.001377823,
0.053408254,
-0.016489731,
0.0052905683,
0.028252587,
0.023729457,
0.022099499,
-0.010255146,
0.006030841,
0.035505895,
0.0052226535,
-0.023036724,
0.009555622,
0.0047981855,
-0.002422863,
0.007375555,
-0.020102803,
0.0030493778,
0.008407861,
-0.020673286,
0.0038337945,
0.0063500404,
-0.016095825,
0.02753269,
-0.022371158,
0.020781951,
-0.01913841,
-0.0022751482,
0.0189075,
0.00004008569,
-0.021529013,
0.0016223165,
0.0149820205,
0.0007351785,
0.0005581753,
-0.007993581,
0.01250992,
0.028904568,
0.02283298,
0.0189075,
0.016557645,
0.013739179,
0.03996111,
-0.006475683,
0.026704127,
0.01183077,
0.013481102,
0.008421444,
-0.020754784,
-0.031023514,
0.022778647,
0.008570856,
-0.00840107,
0.0012920804,
0.030887684,
0.018106105,
0.01475111,
0.009480916,
0.0013498081,
-0.031240841,
-0.038032327,
-0.026541132,
0.0075385505,
0.0009227933,
0.01904333,
0.004781207,
-0.025726153,
-0.01155232,
-0.0057388064,
0.025834817,
-0.013270566,
0.0058203046,
0.0037964412,
-0.016476147,
0.017793696,
0.04197139,
-0.008319572,
-0.00084469124,
-0.004193743,
-0.005681079,
-0.017712198,
0.0035417606,
-0.023539294,
0.007497802,
0.009521665,
-0.006261751,
-0.0232948,
0.017155297,
-0.00664547,
0.020116385,
0.0024687056,
0.025454493,
0.0007364519,
0.029719548,
-0.019029748,
-0.007069938,
0.00073942315,
-0.006862798,
-0.008041121,
0.013657681,
-0.016598394,
0.01894825,
0.03330545,
0.01790236,
0.0015951506,
0.013386021,
-0.037027188,
-0.020646121,
0.00027187172,
0.02151543,
-0.00035082275,
-0.014452284,
-0.016218072,
-0.0044586114,
-0.018296266,
0.0214611,
-0.0065232236,
-0.0036640074,
-0.008387486,
0.0067337593,
0.012163553,
0.014343621,
-0.019219909,
-0.027804349,
-0.013827467,
0.00958958,
-0.02283298,
-0.014764693,
0.008706686,
-0.017888777,
-0.01351506,
-0.0138818,
-0.026595464,
0.011728899,
0.010438516,
0.0048830793,
-0.023580043,
-0.009032678,
-0.0034806372,
-0.019939806,
0.010791673,
0.007966414,
0.014302872,
0.00022093556,
-0.009331503,
0.014560948,
-0.012245052,
-0.011898685,
-0.019844726,
-0.0059799044,
-0.009514874,
0.019817559,
0.025685403,
0.036782693,
0.017848028,
0.005202279,
0.012652541,
-0.023498546,
0.017481288,
-0.019885475,
0.036837026,
-0.006635283,
-0.035044074,
0.015742667,
0.0130939875,
-0.003361786,
0.030697523,
0.016707059,
-0.024924757,
0.007844168,
-0.014588115,
0.024191277,
0.009759367,
0.010289103,
-0.03265347,
-0.0016044888,
0.0040477263,
0.011973392,
0.012231468,
-0.006567368,
-0.014764693,
-0.008468985,
-0.0009907082,
0.003589301,
0.004023956,
-0.011205954,
-0.036429536,
0.009154924,
-0.006248168,
-0.010947878,
-0.005049471,
0.0069307126,
0.02128452,
-0.008890057,
-0.006037632,
0.011817188,
-0.032028653,
0.007823793,
0.016788555,
0.009365461,
0.02283298,
0.021257354,
0.0026571692,
0.0010840911,
-0.010126107,
0.038005162,
-0.010934294,
0.01114483,
0.012958158,
-0.002567182,
0.0065232236,
0.009861239,
-0.013012489,
0.01424854,
0.015959995,
-0.024802512,
0.03306096,
-0.008238073,
0.02594348,
-0.021393184,
0.0094265845,
0.0103909755,
-0.021270938,
0.011851145,
0.00415639,
0.050365668,
0.013134736,
0.016924387,
-0.019328572,
0.008727061,
-0.008034329,
0.021067193,
-0.0039798114,
0.008176951,
-0.008061496,
0.010343435,
-0.012088847,
-0.0048151645,
-0.016068658,
0.011110873,
-0.021311687,
-0.0062889173,
0.01913841,
0.011287452,
0.013678055,
0.010424932,
0.00039878764,
-0.017073799,
-0.036266543,
0.03528857,
0.014859774,
-0.0214611,
-0.028795905,
-0.03004554,
-0.001988208,
-0.018024607,
-0.00017817042,
0.0036232583,
0.010526805,
0.0022343993,
0.029040398,
-0.0116881495,
-0.016448982,
0.008156576,
-0.020075636,
0.001376125,
-0.017345458,
0.01689722,
0.0066692405,
-0.020170717,
0.008557274,
0.023580043,
0.004988347,
-0.02497909,
-0.0036470287,
-0.019518735,
-0.014533782,
0.008672729,
-0.006570764,
0.014017629,
-0.043927338,
0.013372438,
-0.02178709,
0.03808666,
0.0020493313,
0.017562786,
0.020754784,
-0.027328944,
-0.03425626,
-0.001988208,
-0.019668147,
0.023634376,
0.060525734,
0.014357204,
0.015606837,
-0.0019304802,
-0.017060217,
-0.015471008,
-0.029040398,
0.0026130248,
-0.03667403,
0.010513222,
0.014737527,
-0.00059383066,
0.012156762,
0.019953389,
0.029067565,
0.015063519,
-0.03164833,
-0.002806582,
-0.0157155,
0.024571601,
-0.010866379,
0.009148133,
0.025671821,
0.015742667,
-0.01041135,
0.03338695,
0.016340317,
0.010818839,
-0.008917223,
0.0059833,
0.00532113,
-0.013121153,
-0.009555622,
-0.03575039,
-0.041944224,
0.021950087,
0.008305989,
0.010757715,
0.01525368,
0.016448982,
0.010744133,
0.004492569,
-0.0033193394,
-0.010295895,
-0.014805442,
-0.017073799,
-0.0051581343,
-0.0058712405,
-0.024001116,
0.022710733,
-0.0024534247,
-0.005996883,
-0.0077422955,
0.009148133,
-0.0082041165,
0.017467706,
-0.0028269566,
-0.00087610184,
-0.01703305,
0.004754041,
-0.031349506,
-0.006475683,
-0.020265797,
0.009997069,
-0.014275706,
-0.008380695,
-0.011586277,
-0.013922549,
-0.009535247,
0.03325112,
-0.0441175,
-0.025006255,
0.017644284,
0.0041529946,
0.005229445,
0.010153273,
-0.0061123385,
0.016462564,
0.018146854,
-0.0006120828,
-0.018201185,
0.004302407,
-0.03566889,
0.018649423,
-0.01790236,
-0.021814257,
-0.022371158,
-0.005080032,
-0.006703198,
0.011878311,
-0.015457424,
0.014330038,
0.006662449,
-0.008102244,
0.0004792243,
0.015294429,
0.009698244,
0.018798836,
0.009202465,
-0.0077694613,
-0.030887684,
-0.018106105,
-0.02936639,
-0.015308012,
0.00072202,
0.019151993,
0.009317921,
-0.0059018023,
-0.008387486,
-0.0031308755,
0.008740644,
-0.0031342714,
0.0054399814,
0.006849215,
0.015851332,
-0.0006146296,
0.00940621,
0.012720455,
0.004448424,
-0.0052769855,
-0.02086345,
0.028877404,
-0.009243214,
-0.01689722,
-0.00020024275,
-0.0021647864,
0.0012284103,
-0.011294243,
-0.009555622,
-0.00093807414,
0.03137667,
0.010655844,
-0.012306174,
-0.0083535295,
-0.025277914,
-0.02685354,
-0.01840493,
-0.012346923,
-0.022710733,
-0.010064984,
-0.0016240143,
-0.016150156,
-0.003400837,
-0.0020883824,
-0.029420722,
-0.011199162,
0.020673286,
0.015810583,
-0.009487707,
-0.012007349,
0.0043635303,
-0.034636583,
-0.014275706,
-0.023226885,
-0.03009987,
0.00028205896,
0.0032565182,
0.035994884,
0.02319972,
0.018228352,
-0.0126117915,
0.0011239911,
0.01945082,
0.0055792066,
0.017223211,
0.001760693,
0.0030952203,
-0.031947155,
0.032028653,
-0.0054773344,
-0.0063058957,
0.037271682,
-0.00050554133,
-0.00023069832,
0.022371158,
-0.011063333,
-0.004859309,
0.010173648,
-0.036239374,
-0.02635097,
0.031349506,
-0.021488266,
-0.0007177753,
-0.037190184,
-0.009623537,
0.025997812,
0.014357204,
0.004275241,
0.01214997,
0.016231654,
-0.0189075,
0.0069069425,
0.004489173,
0.022411907,
0.0072600995,
-0.014397953,
0.013990464,
-0.009827282,
-0.007959623,
-0.00026762704,
0.00015058,
0.0019763228,
-0.013345272,
-0.0046283985,
0.000054756365,
-0.021121524,
-0.020225048,
-0.01712813,
0.00028099777,
-0.03471808,
-0.016611978,
-0.013528642,
-0.035913385,
0.004777811,
-0.007966414,
-0.022928061,
0.0031410628,
-0.0040341434,
-0.010486056,
0.035315733,
-0.013623723,
0.027301779,
-0.003640237,
0.009446959,
0.032707803,
-0.0057965345,
-0.01844568,
0.0061123385,
-0.000057833757,
0.0143164545,
0.031892825,
0.016095825,
0.006146296,
-0.016489731,
-0.002450029,
0.014031213,
-0.032762133,
-0.053353924,
0.02142035,
-0.00080946035,
0.009283963,
-0.022602068,
-0.015688336,
-0.029665215,
0.02379737,
-0.015471008,
-0.00347045,
-0.0030425861,
-0.008170159,
-0.025400162,
0.019532317,
0.0009703337,
0.024082614,
-0.010465682,
-0.027573438,
-0.02443577,
-0.012645749,
-0.0058474704,
-0.015457424,
-0.008272031,
0.028714407,
-0.0040884754,
0.010248354,
0.01790236,
-0.0029831608,
0.0061259214,
-0.013603348,
-0.003867752,
0.03713585,
0.000039369403,
-0.006499453,
0.01374597,
-0.012666124,
0.005280381,
-0.0130939875,
0.004903454,
-0.006421351,
-0.034582254,
-0.012598209,
0.026323805,
0.006794883,
-0.025780486,
0.008319572,
-0.018649423,
0.0066047213,
-0.028469915,
-0.00532113,
0.007979997,
-0.03686419,
-0.012829119,
-0.0046521686,
0.009664286,
0.027845098,
0.013535433,
-0.0031308755,
0.0032293522,
0.050365668,
-0.040368598,
0.0053856494,
-0.002925433,
0.0034806372,
-0.020347295,
0.0023617398,
0.0072872657,
-0.024625933,
0.021379601,
-0.029040398,
-0.014289289,
0.014357204,
-0.0138342595,
0.02658188,
0.02219458,
-0.012116013,
0.008665938,
-0.013046447,
0.01287666,
0.0058406787,
0.008604814,
0.025495242,
-0.010499639,
0.02300956,
-0.0070359805,
-0.010886754,
-0.041074913,
0.0008485114,
-0.0003079515,
0.01858151,
-0.0020051866,
0.0042039305,
-0.02501984,
-0.023349132,
-0.012930991,
-0.015498173,
0.0026537736,
-0.0014202697,
-0.024327107,
-0.0049917432,
0.0069307126,
-0.029230561,
-0.0022140248,
0.002781114,
-0.012795161,
-0.007776253,
-0.03311529,
-0.015837748,
-0.0009058146,
-0.031566832,
-0.026187975,
0.004006977,
-0.035424396,
0.030616025,
0.01342677,
-0.022860145,
-0.013372438,
-0.0037251306,
-0.045856122,
-0.013813885,
-0.0057557854,
0.0009779742,
0.0064553083,
0.0039560413,
-0.02594348,
-0.008876474,
-0.0033702755,
0.018418513,
0.014330038,
-0.008272031,
0.026568297,
-0.009922363,
0.0038847306,
0.010329852,
-0.024897592,
-0.017426956,
0.035315733,
-0.012299383,
-0.015471008,
0.02571257,
-0.021012861,
0.009440167,
-0.00935867,
-0.007708338,
0.009148133,
0.020659704,
0.020469543,
-0.015104268,
-0.02004847,
-0.0026571692,
0.0030425861,
0.0033736713,
0.010846005,
0.016353901,
0.021950087,
-0.015294429,
-0.0040443307,
-0.012774787,
-0.0022683567,
-0.0049475986,
0.027709268,
0.030344365,
0.01351506,
0.010221188,
0.0069544828,
-0.009840865,
-0.006703198,
0.004625003,
-0.021080775,
-0.005365275,
0.028279752,
-0.007925666,
-0.0107237585,
-0.0037013604,
0.02228966,
-0.027695684,
0.0050528664,
-0.010553971,
-0.0009083614,
-0.026785625,
0.0040443307,
0.011049749,
-0.010445307,
-0.007375555,
-0.013841051,
0.0050223046,
-0.014207791,
-0.012829119,
-0.00072626467,
-0.03996111,
-0.0020595184,
0.0054637515,
-0.0023108034,
-0.0040884754,
0.0076607973,
-0.021298103,
-0.015810583,
0.01488694,
0.2040706,
-0.019939806,
0.01693797,
-0.008543691,
0.00056878704,
0.0022259098,
0.00712427,
-0.015661169,
0.017141713,
0.0023600417,
0.013148319,
0.013263774,
-0.018078938,
-0.009487707,
0.016285986,
-0.004845726,
-0.0328708,
-0.021040028,
-0.029665215,
-0.005928968,
0.002714897,
-0.012801954,
0.025631072,
-0.016951552,
0.021366019,
0.015226514,
-0.03050736,
0.00288808,
0.009616746,
0.0014839399,
-0.044361994,
0.001469508,
-0.0036300498,
0.00072202,
0.035913385,
0.015280846,
-0.03501691,
-0.019192742,
-0.0026266077,
-0.0034806372,
0.012489545,
0.031702664,
0.019994138,
0.0046012327,
-0.0031970926,
0.0054705427,
-0.004859309,
-0.012136388,
0.006635283,
0.012917409,
-0.059384763,
0.011239911,
0.011627026,
0.019369321,
-0.0035383648,
-0.0066760317,
-0.0063636233,
0.00031283288,
-0.0013727293,
0.029230561,
-0.015701918,
-0.0004134318,
-0.034908243,
0.016000744,
-0.016951552,
0.046345107,
-0.003402535,
0.015511757,
0.02631022,
-0.021977253,
0.012163553,
0.010486056,
-0.031240841,
-0.004265054,
-0.0109818345,
-0.013216234,
0.021732759,
0.011253494,
0.023077473,
0.026418885,
0.006764321,
0.0048796837,
-0.0046827304,
0.007966414,
-0.011239911,
-0.026758458,
0.005351692,
0.014221374,
0.013066821,
-0.0030273055,
0.02366154,
0.007708338,
0.00014463745,
0.009236422,
0.0057795555,
0.008733853,
0.0070156064,
-0.013365647,
0.00041725198,
-0.0028812885,
-0.029149063,
0.08008522,
0.018921083,
0.008706686,
-0.02095853,
-0.0047200834,
0.021990836,
0.030072706,
0.010064984,
-0.014601697,
0.00013020555,
-0.011409698,
0.003589301,
-0.010879963,
-0.00037968656,
0.014397953,
-0.003006931,
-0.012679706,
0.035994884,
-0.013121153,
0.0028371438,
-0.028116757,
-0.008285615,
0.03191999,
-0.012849494,
0.005986696,
-0.012007349,
-0.003467054,
0.0038066285,
0.003285382,
-0.00977295,
-0.0067337593,
0.00744347,
-0.003969624,
-0.005782951,
-0.011620235,
0.027152365,
0.012082055,
0.0070903124,
0.005389045,
-0.01274083,
-0.019464402,
-0.015647586,
0.0029627862,
-0.010907128,
-0.0082041165,
0.0012097337,
0.021148691,
0.002132527,
0.0071310615,
0.007083521,
-0.034908243,
-0.005497709,
-0.0052260496,
0.01379351,
-0.0390918,
-0.03996111,
-0.045502964,
0.0019780206,
0.0054943133,
-0.023498546,
0.00077125826,
0.022506988,
-0.018486427,
-0.018622257,
0.018934665,
-0.17212345,
0.015049935,
0.021950087,
-0.027464774,
0.020741202,
0.0031970926,
-0.0055045,
-0.016041493,
-0.0058848234,
0.014017629,
0.03648387,
-0.00089223165,
-0.040613092,
-0.026704127,
0.0046283985,
0.013684846,
0.0062651467,
0.030724688,
-0.0019304802,
0.018744504,
0.0037590882,
-0.018554343,
0.018758088,
0.0027896033,
0.003431399,
0.0011239911,
-0.0157155,
-0.029339224,
-0.002142714,
0.011301034,
-0.005260007,
0.0098340735,
0.046915594,
-0.0061259214,
0.04574746,
0.008109036,
0.009005512,
-0.007966414,
-0.0113146175,
0.024381438,
0.028741574,
0.021121524,
0.017522037,
0.010689801,
-0.02402828,
0.01749487,
-0.0031869053,
-0.00020947494,
0.016408233,
0.0009694848,
0.019722478,
-0.023457797,
-0.0065096403,
0.016122991,
0.036456704,
0.02612006,
0.022140248,
0.009080218,
0.0008204965,
-0.009256797,
-0.015701918,
-0.016598394,
0.045611627,
0.002541714,
-0.0030816372,
-0.048301056,
0.00057897426,
-0.012360507,
-0.010146482,
0.0029220374,
-0.023919618,
-0.025671821,
0.014642446,
-0.02287373,
0.018567925,
0.01790236,
0.009114176,
0.03713585,
-0.00013105448,
0.0013846144,
-0.0013328294,
0.01054718,
-0.013066821,
-0.02635097,
-0.0033821606,
-0.027342526,
0.016109407,
0.02936639,
0.005582602,
-0.011993766,
0.002939016,
-0.02617439,
0.019858308,
-0.016421815,
0.027301779,
0.019328572,
-0.00036016107,
-0.0056776833,
-0.001933876,
-0.004214118,
0.01662556,
0.0014533782,
-0.0070088147,
-0.0023074078,
0.027790766,
0.0077422955,
-0.011287452,
0.0064519127,
0.019301407,
-0.010255146,
-0.008822142,
0.0014618676,
0.00024046109,
0.015308012,
-0.01465603,
0.004835539,
-0.0002525584,
-0.0040477263,
-0.00060826255,
-0.030860517,
0.06671957,
-0.005996883,
0.00023069832,
0.00089223165,
0.0010739039,
-0.032816466,
-0.13843767,
-0.017970275,
0.016068658,
0.027016535,
-0.04197139,
0.025182834,
0.015077101,
0.024653098,
-0.024245609,
0.026405303,
-0.024109779,
-0.006434934,
-0.00089223165,
-0.007226142,
-0.0009423188,
-0.024666682,
0.03064319,
-0.014411536,
-0.024680264,
0.034500755,
-0.004346552,
-0.0006702349,
0.010071775,
-0.007558925,
0.00065452955,
0.008380695,
-0.0155389225,
0.0043906965,
-0.005691266,
-0.0018897313,
0.016707059,
-0.021542598,
0.043166693,
0.0019593441,
-0.03716302,
-0.000827288,
-0.015919246,
-0.025318664,
0.019885475,
-0.018201185,
0.0018286079,
0.0056165596,
0.0050664493,
0.025563158,
-0.020781951,
-0.013311314,
-0.025522409,
0.009175299,
0.015579672,
-0.011776439,
-0.025916316,
-0.025834817,
-0.016598394,
0.0005573264,
0.0264868,
-0.002606233,
0.016136574,
0.030480195,
-0.014819025,
-0.010900337,
-0.020809116,
0.01096146,
-0.012217885,
0.0007207466,
0.02580765,
0.005389045,
-0.022765065,
-0.036348037,
0.023851702,
0.0029576926,
-0.0061089424,
-0.00579993,
-0.013542226,
-0.012414838,
-0.04303086,
-0.0010102337,
-0.003928875,
-0.02420486,
0.019233491,
-0.018730922,
-0.021841422,
-0.025875567,
0.0038168158,
-0.005827096,
0.024598766,
-0.0049611814,
0.005175113,
-0.013297732,
0.012951366,
-0.009630329,
0.014370787,
0.031213675,
-0.0024466333,
-0.016462564,
-0.0034840328,
0.0023006164,
0.0045095473,
-0.019029748,
0.015335178,
0.034908243,
-0.020700453,
-0.006115734,
-0.061395045,
0.009752575,
0.0027963948,
-0.0034330967,
0.025291499,
-0.0029186415,
0.0058440748,
-0.0047200834,
0.016068658,
0.008034329,
-0.012747621,
0.01735904,
0.0073144315,
0.021121524,
-0.018975414,
-0.012543877,
0.040124107,
-0.022085916,
0.005056262,
0.035505895,
-0.0025790671,
-0.0048117684,
0.0066658445,
-0.001961042,
-0.008604814,
-0.021067193,
-0.004485777,
0.028660076,
-0.001377823,
0.0018727526,
-0.015742667,
-0.03982528,
-0.005932364,
-0.014805442,
-0.004394092,
-0.027573438,
-0.010289103,
0.02155618,
0.00840107,
0.029991208,
-0.0135014765,
-0.04438916,
0.020075636,
0.006356832,
0.01465603,
0.010628677,
-0.024422187,
-0.018391347,
0.004006977,
-0.0049475986,
0.03219165,
0.011912269,
-0.004781207,
-0.015946412,
-0.008414652,
0.008421444,
-0.009528456,
-0.019885475,
-0.010615095,
-0.018296266,
0.030860517,
0.010995418,
-0.0005819455,
0.019654565,
0.010377392,
0.014547366,
-0.036076378,
0.008699895,
0.023077473,
-0.004709896,
-0.028877404,
0.0003824456,
0.031105012,
0.0013014188,
0.030018372,
-0.0021529014,
-0.014601697,
-0.0032904756,
-0.02434069,
0.011294243,
0.023131805,
0.0258484,
-0.025563158,
0.015362344,
0.0024398419,
0.0007037679,
-0.0019814165,
0.009854448,
0.0066420743,
-0.018051773,
0.006054611,
0.039526455,
0.019355739,
0.00054077216,
-0.0030357947,
0.029203394,
-0.014207791,
-0.00067745085,
0.026513966,
0.02059179,
0.0032378414,
-0.0054331897,
0.01329094,
-0.0068797763,
0.00066047214,
0.014126293,
-0.04137374,
-0.033441283,
-0.0015671357,
-0.02178709,
0.015701918,
0.0031020117,
0.0066896146,
0.0026945225,
-0.011233119,
0.0019491568,
0.022276077,
-0.010995418,
-0.00347045,
0.033441283,
0.023851702,
0.021203022,
0.0012224676,
-0.007640423,
-0.0002604111,
0.004781207,
0.007497802,
-0.029094731,
0.026907872,
-0.02612006,
0.0056471215,
-0.0077015464,
-0.030724688,
-0.011606651,
-0.0020476333,
-0.011742481,
-0.004370322,
0.006197232,
0.0020306546,
0.09149492,
-0.0009117572,
-0.014873357,
-0.008292406,
-0.00958958,
0.0071989764,
-0.0005140307,
0.025196418,
-0.031675495,
-0.031485334,
0.017372625,
-0.017603535,
0.031865656,
-0.03393027,
-0.026323805,
0.004023956,
-0.03164833,
0.021298103,
-0.0044654026,
-0.020320129,
0.019151993,
-0.011762856,
-0.0127612045,
0.004265054,
-0.021175858,
0.01397688,
0.02165126,
-0.0074163037,
-0.003640237,
-0.013820676,
0.0065605766,
-0.00085233164,
-0.03575039,
-0.0009601465,
-0.0050766366,
-0.008102244,
-0.014438702,
-0.017915944,
0.0082788225,
0.024354273,
0.005266798,
0.018024607,
-0.011701732,
-0.020578206,
0.030779019,
-0.0049170367,
-0.02269715,
-0.003721735,
0.0022089311
] |
CONTEXT Vaso-occlusion is central to the painful crises and acute and chronic organ damage in sickle cell disease. Abnormal nitric oxide-dependent regulation of vascular tone, adhesion, platelet activation, and inflammation contributes to the pathophysiology of vaso-occlusion. Nitric oxide may have promise as a mechanism-of-disease-based therapy for treatment of vaso-occlusion. OBJECTIVE To explore the efficacy and safety of inhaled nitric oxide (INO) for treatment of vaso-occlusive crisis in pediatric patients. DESIGN Prospective, double-blind, placebo-controlled, randomized clinical trial with enrollment between September
|
[
-0.010124365,
-0.01761507,
0.00913178,
-0.025939548,
-0.022525057,
0.02837469,
-0.019944336,
-0.0056544244,
-0.035124265,
0.009105311,
0.012592592,
-0.001090189,
0.032477375,
0.0090523735,
0.01541815,
0.0032440978,
0.034886047,
-0.015510791,
0.0080465535,
-0.01852825,
-0.018223856,
0.030201046,
-0.018951751,
-0.0152196335,
-0.006104396,
-0.0030174577,
0.011619859,
-0.04640003,
0.012896985,
-0.048941046,
0.012268348,
0.010091279,
-0.0029562484,
-0.009158249,
-0.011024308,
-0.008139195,
-0.019970806,
-0.016993051,
-0.013790311,
-0.0013830015,
0.022141257,
-0.0034244175,
0.0053301803,
-0.013346956,
-0.013578559,
0.010746384,
-0.006521282,
-0.008728129,
-0.025119012,
0.0104419915,
0.022988264,
0.008192133,
0.008800918,
0.010382437,
0.007206165,
-0.015113757,
0.007623051,
0.006001829,
-0.0138300145,
-0.019348785,
-0.010521399,
0.0029860258,
-0.018276794,
0.016582783,
-0.026588038,
0.008020085,
0.007252486,
0.016357796,
-0.0036229345,
0.0034078744,
0.04441486,
0.037321188,
-0.012744788,
0.0044302368,
0.0122484965,
-0.010415523,
-0.02552928,
-0.018250326,
0.0032788385,
-0.00067495764,
0.020672232,
-0.029248165,
-0.03287441,
0.02517195,
0.025092542,
-0.00032775977,
0.0020265272,
0.01752243,
-0.024827853,
-0.004066289,
0.009694245,
0.020195791,
0.00024235611,
-0.0069150073,
-0.0050621824,
0.027077712,
0.0020381075,
0.022498589,
0.0020166014,
0.0034674294,
0.007285572,
-0.015100523,
-0.012175706,
-0.011553687,
-0.011090481,
0.004764407,
-0.010197154,
0.009409703,
0.018634126,
-0.0059753605,
-0.025846908,
0.050158616,
-0.010812556,
-0.009985403,
0.016834239,
-0.015471088,
0.018051809,
-0.002600572,
-0.017098928,
-0.035362486,
-0.009383235,
0.0015244448,
0.021042798,
-0.019878164,
-0.0011108678,
-0.009237655,
-0.011600007,
0.0021704521,
-0.0075568785,
-0.018012105,
0.0060282983,
0.032953814,
0.0024599559,
-0.032450903,
0.00013038014,
0.015722543,
-0.020698702,
-0.013088885,
-0.018422373,
-0.025370467,
-0.003685798,
0.030783363,
-0.022167727,
0.0104419915,
0.0026717074,
0.022300072,
0.017218037,
0.014743192,
0.014385862,
-0.011494132,
0.0062499754,
-0.01974582,
-0.017443024,
-0.0132278465,
-0.00059472374,
0.022988264,
-0.018065043,
0.027792374,
-0.007682606,
-0.0070076487,
-0.0068686865,
-0.021056032,
0.008496526,
-0.008397267,
0.0003974475,
0.0034045659,
-0.013578559,
-0.011467663,
-0.003738736,
0.0080465535,
-0.02333236,
0.0448913,
-0.00032279684,
0.012169089,
-0.0056246473,
0.010534633,
0.02306767,
0.033880226,
0.012122769,
-0.0148225995,
-0.020764874,
0.00015767623,
0.016728362,
0.0110441595,
-0.009866293,
-0.0025658316,
0.051667348,
-0.0069745625,
0.009859676,
-0.011202973,
0.011547069,
0.01903116,
-0.021611879,
-0.004737938,
-0.64075977,
-0.011507366,
0.0064981217,
-0.0010819174,
0.028295284,
0.01408147,
0.016503377,
0.01073315,
-0.01838267,
0.027289463,
-0.017098928,
0.033033222,
-0.012294817,
-0.007728927,
-0.004893443,
-0.02713065,
0.0011613242,
-0.0043475213,
0.029512854,
-0.021294251,
0.00456589,
-0.0078480365,
-0.0098530585,
0.0140285315,
0.011805141,
0.02354411,
0.020394308,
-0.011864697,
-0.019560536,
0.015524026,
0.02505284,
-0.0013523968,
0.006795897,
0.021664817,
0.049655706,
-0.026760085,
0.010124365,
0.022458885,
-0.007986999,
0.021453066,
-0.02440435,
0.004873591,
0.02834822,
-0.011930869,
0.0062929876,
0.016966583,
0.016529845,
-0.023755861,
-0.004873591,
0.002567486,
0.0122484965,
-0.005614721,
-0.012347754,
0.024708744,
0.0056577334,
-0.02098986,
0.028507035,
-0.0016816041,
0.0025592144,
0.019150268,
-0.026230708,
0.0051283548,
-0.008999435,
-0.03721531,
0.03896226,
0.038988728,
-0.03877698,
0.016291624,
0.012625678,
-0.00077132107,
0.011957338,
0.030386329,
-0.0045096437,
-0.018184153,
0.011375021,
0.031445086,
0.0034773552,
0.022577995,
-0.027792374,
0.017310679,
0.0043640644,
0.01135517,
-0.01604017,
0.0037321188,
0.044600144,
0.0040464373,
-0.032186214,
0.018078277,
0.020526653,
-0.019137034,
0.009303828,
0.0024798077,
-0.01995757,
-0.042085595,
-0.010428757,
0.0316039,
0.022048617,
0.013644732,
0.010197154,
-0.008423736,
-0.018898815,
-0.0052904766,
-0.030227514,
-0.020447247,
-0.0016791226,
0.019467896,
-0.032133278,
-0.010130982,
0.038141724,
-0.045235395,
0.0066635525,
0.00033334305,
0.0025112394,
-0.018395904,
0.002239933,
-0.02368969,
0.013882953,
0.012758023,
-0.0037519704,
-0.024589634,
-0.008761215,
-0.0092575075,
-0.017456258,
-0.015973998,
0.007841419,
-0.028242346,
-0.016146045,
-0.0067264163,
-0.02837469,
-0.02638952,
-0.0065179733,
-0.018184153,
0.024166131,
-0.0011365096,
0.016344562,
-0.012844047,
0.026058659,
0.015788715,
0.014716724,
-0.035971273,
-0.010693447,
-0.008920029,
0.0023160311,
0.018303264,
-0.016940113,
-0.012685234,
0.001981861,
0.0071135242,
-0.0016270119,
-0.007444386,
-0.0051184287,
-0.03253031,
-0.012407309,
0.025185185,
-0.010964753,
-0.0057404484,
-0.0144255655,
-0.009575134,
-0.028798193,
-0.0034674294,
0.0014268407,
0.0037486618,
-0.023888206,
-0.015074054,
-0.02863938,
-0.014055001,
-0.0021621806,
0.017840058,
0.015497557,
-0.035838928,
-0.0039405613,
-0.042826723,
-0.01656955,
0.015524026,
-0.0014706798,
0.015404915,
-0.026614506,
-0.021572176,
-0.0023772405,
0.016384266,
-0.008933263,
-0.024642572,
0.0038743892,
0.011202973,
0.0142138135,
-0.0026899048,
0.013201377,
0.041397404,
-0.0037188842,
0.044997178,
-0.011004456,
0.009462642,
-0.036130086,
0.023147076,
-0.015815184,
-0.021188376,
-0.017363617,
0.0069216243,
0.00000633936,
0.040126894,
0.041291527,
-0.029036414,
0.02911582,
-0.007656137,
0.019825226,
-0.014504972,
-0.0044997176,
0.0039901906,
0.030545142,
0.0024185982,
0.0028404468,
0.020407543,
-0.0037122671,
-0.0008151602,
0.011520601,
0.006554368,
0.0030124949,
-0.0112426765,
0.01799887,
0.0002663436,
-0.021903038,
-0.020195791,
0.01998404,
0.00039248457,
-0.02570133,
0.00057363126,
0.014359393,
-0.0008999435,
-0.0017320605,
-0.026614506,
-0.026336582,
-0.0002801984,
-0.0015294077,
-0.014478503,
0.0013788657,
0.019110566,
0.007133376,
-0.0016088145,
0.027236527,
0.022180961,
0.014279986,
0.0058628675,
0.025211653,
-0.003986882,
0.021333955,
-0.0075833476,
0.023385298,
-0.012367606,
-0.012427161,
0.0045625814,
0.0011290652,
-0.0009090422,
-0.017350381,
-0.01166618,
-0.0075105582,
-0.006855452,
0.003019112,
0.0152196335,
0.046188276,
0.014002062,
0.035018392,
0.0047776415,
0.009958934,
-0.02271034,
0.008622253,
-0.003421109,
-0.006220198,
-0.000038721144,
-0.0065345163,
0.007285572,
-0.024496993,
-0.0042284112,
-0.0057900776,
-0.022630934,
0.026614506,
0.0035567621,
0.011394873,
0.0066304663,
0.018250326,
-0.0033334305,
0.023239719,
-0.02366322,
0.022855919,
0.0084634395,
-0.0024566473,
-0.0029463226,
-0.0092442725,
-0.0027196822,
-0.012976391,
0.025105778,
0.0023292657,
0.014293221,
0.017654775,
-0.015034351,
-0.0073186583,
-0.011064012,
0.01704599,
-0.0008569315,
0.0041920166,
0.00052234775,
0.004019968,
-0.003131605,
-0.008609018,
-0.0032474066,
0.026018955,
0.0015881356,
0.013525622,
-0.002524474,
-0.0052606994,
-0.0097538,
0.023649987,
-0.024338178,
-0.01233452,
-0.015140226,
0.013962359,
0.0142138135,
-0.0032639496,
-0.0034740467,
0.019282613,
-0.029830482,
0.013644732,
-0.021029564,
0.008959732,
-0.014478503,
0.031656835,
-0.0019950953,
-0.010554485,
0.03679181,
-0.001283743,
-0.00019810337,
-0.0043375953,
-0.03107452,
0.019110566,
-0.013499153,
0.022604464,
0.0044203107,
0.006375703,
0.0031646912,
0.0090457555,
0.034674294,
0.006802514,
-0.016238688,
-0.025343997,
0.0016427278,
0.005985286,
0.0036030826,
0.015153461,
0.04663825,
0.018131215,
-0.021069266,
-0.0003180407,
0.010614039,
0.023292655,
-0.010382437,
-0.013327105,
0.028507035,
-0.010528016,
0.009283977,
-0.033218503,
-0.027739435,
-0.0048636654,
0.0015790369,
0.032265622,
0.015285806,
0.015378446,
0.018329732,
0.0014715069,
0.0012688542,
-0.001460754,
-0.023610283,
0.0027577314,
-0.0010835717,
-0.0023110681,
-0.015696073,
0.029221695,
-0.009283977,
0.0041291527,
-0.037824098,
0.011394873,
-0.005710671,
-0.008178898,
0.002498005,
0.009006052,
0.012182324,
-0.027951187,
-0.034674294,
0.019467896,
-0.0323715,
-0.03178918,
-0.026243942,
-0.026257176,
-0.0032192832,
-0.024033787,
0.0028288667,
0.019759053,
0.013856484,
-0.024444055,
0.022697106,
0.029248165,
-0.007993616,
0.03205387,
-0.014849069,
-0.001842899,
0.0076627545,
-0.0068289833,
-0.019044394,
-0.0075767306,
-0.017588602,
-0.0090457555,
-0.0026386213,
0.007252486,
0.003679181,
-0.015960762,
-0.011745586,
0.041926783,
-0.018541483,
-0.008073023,
-0.022472119,
0.004248263,
0.015815184,
0.024391117,
0.027342401,
-0.02502637,
-0.019150268,
0.0056014867,
-0.029936356,
-0.007728927,
-0.02357058,
-0.0019272688,
-0.0024037093,
-0.01778712,
0.017284209,
0.023994083,
-0.018660594,
0.010977987,
-0.009145014,
-0.01740332,
-0.010951519,
0.00064311223,
0.016993051,
-0.0035005156,
0.04621475,
0.004909986,
0.005144898,
-0.009879527,
0.011699266,
0.022432417,
-0.015960762,
-0.009819972,
0.013657967,
0.012566123,
-0.01666219,
-0.023861738,
0.009065608,
0.014531441,
0.034753703,
-0.0025608686,
-0.011752204,
-0.039835736,
-0.002679979,
-0.011738969,
0.004909986,
-0.0053070197,
-0.030651018,
0.0046552224,
0.0007928271,
0.004909986,
-0.016000466,
0.060084466,
-0.028030595,
-0.0057073627,
-0.007001031,
-0.020553121,
-0.014279986,
-0.027501216,
-0.009667776,
-0.001068683,
-0.002901656,
-0.022723574,
-0.029671667,
-0.032186214,
-0.00021898902,
0.01885911,
0.02529106,
0.03904167,
-0.015272571,
-0.0011216208,
0.011103715,
0.009224421,
0.022511823,
-0.01615928,
0.004185399,
-0.019414958,
0.036553588,
0.0025443255,
-0.0071863136,
0.0065841456,
-0.039597515,
-0.0028090149,
0.0048173447,
-0.017456258,
-0.018409139,
-0.018435609,
-0.036871217,
-0.014769661,
0.02911582,
0.0037420446,
-0.010772853,
-0.04274732,
-0.0045063347,
0.036632996,
-0.009270742,
0.010276561,
-0.021929506,
-0.001933886,
-0.008542846,
0.011070629,
-0.0039571044,
0.011375021,
0.0060448414,
-0.009694245,
-0.00014640625,
-0.008569315,
0.0024268697,
0.008569315,
-0.002368969,
0.0024616101,
-0.018065043,
-0.035865396,
0.031498022,
-0.016582783,
0.0034045659,
0.0261513,
-0.010786088,
0.00091317797,
0.00066420465,
-0.028004125,
-0.021386893,
0.009462642,
0.016966583,
0.0011604971,
0.004605593,
-0.043991357,
-0.008284775,
-0.0020645764,
-0.025383702,
-0.005684202,
-0.013088885,
0.028242346,
0.001397063,
-0.000988449,
-0.01455791,
-0.0067826626,
-0.004314435,
-0.013618263,
0.0116330935,
0.005177984,
-0.020553121,
-0.007080438,
0.0044732485,
0.016463673,
-0.022353008,
-0.03152449,
0.030492203,
0.012486717,
-0.004178782,
-0.02268387,
-0.018104747,
-0.0020017126,
0.026971838,
0.0011100406,
-0.0088472385,
0.008972966,
-0.015457854,
-0.013346956,
0.019428192,
-0.008470057,
0.02371616,
0.020500185,
-0.0036758722,
-0.011884549,
-0.0019570463,
-0.01023024,
0.0047842585,
0.00062780984,
0.03427726,
0.00041399058,
-0.011388256,
-0.0033019986,
0.019931102,
0.006408789,
0.0006232605,
-0.00045576185,
0.04163562,
0.008264923,
-0.011103715,
0.043064944,
-0.0080465535,
-0.012513185,
-0.01852825,
-0.0004929838,
-0.03282147,
-0.024139661,
-0.009138397,
0.02938051,
0.0064253323,
-0.023636753,
0.0041589304,
-0.009601603,
-0.02908935,
0.004850431,
-0.0017601837,
0.007073821,
-0.028480565,
-0.0063955546,
0.0069017727,
-0.021042798,
0.008562698,
-0.018290028,
0.00051862554,
0.0021853407,
0.014266752,
-0.012652148,
0.022776512,
0.013737373,
0.0077884817,
-0.003685798,
-0.0024748447,
-0.019428192,
-0.02443082,
0.014782896,
0.017535664,
-0.03896226,
0.01381678,
0.0012382495,
-0.0084634395,
0.0014111247,
-0.009707479,
0.0245764,
0.003384714,
0.0061705685,
-0.012896985,
-0.010772853,
0.031895056,
-0.022723574,
-0.0014921858,
0.020103151,
-0.028692316,
-0.016132811,
0.0026584729,
0.0075105582,
0.029486384,
0.0063161477,
-0.018581187,
-0.029142288,
0.013108736,
-0.016146045,
-0.024351412,
-0.01618575,
0.00052731065,
-0.005968743,
0.0055518574,
0.008516378,
-0.015947528,
-0.01627839,
0.0063359994,
-0.0065146647,
0.000467342,
-0.0102500925,
0.0074642375,
0.009859676,
-0.008536229,
-0.04224441,
-0.023054436,
-0.005770226,
0.02392791,
0.024219068,
0.00056205114,
-0.030651018,
-0.0005798349,
-0.050132148,
-0.001552568,
-0.017800353,
0.01345945,
0.026045425,
0.00021361251,
0.010991222,
0.013174908,
-0.008615636,
0.00069480937,
-0.011798524,
-0.0090457555,
0.035627175,
-0.0055849436,
0.030412797,
-0.0072260173,
-0.03234503,
0.0044931006,
0.025185185,
0.0019272688,
0.010104513,
0.018104747,
0.022604464,
0.019084096,
-0.005088651,
0.01183161,
-0.01049493,
0.0023375372,
-0.007986999,
-0.029645199,
-0.017932698,
0.010197154,
0.0073782136,
-0.021810396,
-0.00094791845,
-0.0092442725,
0.006279753,
-0.0060944706,
-0.0033086159,
-0.0077223093,
-0.006279753,
-0.0022548218,
-0.008867091,
0.028321752,
-0.02938051,
0.026230708,
0.002390475,
0.0009925847,
-0.0058297813,
0.019375255,
0.009489111,
-0.0027246452,
0.012486717,
-0.0051879096,
-0.018462077,
0.016053405,
0.0006964636,
-0.026243942,
0.0036163172,
-0.0037155757,
-0.0031547653,
-0.014385862,
-0.0015335435,
0.0043409043,
0.019666413,
-0.000008691579,
0.010753002,
-0.043567855,
-0.0069017727,
-0.005039022,
0.018038575,
-0.008324478,
0.007973764,
-0.013882953,
-0.002600572,
-0.0039240182,
0.005763609,
-0.02072517,
-0.0022051926,
0.027368871,
0.184859,
0.032159746,
-0.006690021,
0.02882466,
-0.007020883,
0.0033499736,
0.00937,
-0.026455693,
0.0016137774,
0.009217804,
0.02478815,
0.0041423873,
0.0104419915,
-0.009614837,
0.010700064,
-0.022392713,
-0.00071838323,
-0.02232654,
0.0038181427,
-0.030306922,
-0.035706583,
-0.006961328,
0.023411766,
0.00095949863,
0.022630934,
-0.009204569,
0.0075436444,
0.011977189,
0.03157743,
0.045738306,
-0.006961328,
0.017535664,
0.011619859,
0.01862089,
0.01725774,
-0.0058694845,
0.010150834,
-0.025264591,
-0.009231038,
0.013174908,
-0.0011232751,
0.008708277,
-0.03184212,
-0.011924252,
-0.015100523,
0.042509098,
0.005866176,
-0.007953913,
-0.041582685,
0.0063690855,
-0.035097796,
-0.00874798,
0.0057073627,
0.032450903,
0.009356766,
-0.0007514694,
0.018700298,
0.01998404,
0.0020496876,
-0.026826257,
-0.0030803215,
0.0053103287,
-0.0031299507,
-0.01764154,
-0.004929838,
0.0106537435,
-0.019137034,
-0.025542514,
-0.018779704,
-0.008761215,
0.015775481,
-0.03033339,
-0.008284775,
-0.018329732,
-0.01778712,
-0.018713532,
0.01862089,
0.017562132,
-0.015193164,
0.008020085,
0.000031380154,
-0.0010777817,
-0.01271832,
0.006081236,
-0.020698702,
-0.039782796,
-0.0044500884,
0.005416204,
-0.020936921,
-0.0048636654,
-0.010475078,
-0.0049232203,
-0.023676455,
-0.011176504,
0.0014954944,
0.0025145481,
0.0098398235,
0.0071002897,
0.0001905556,
-0.00008555874,
-0.021506004,
0.09121192,
0.0011001148,
0.0049496894,
0.008476674,
0.020566357,
-0.020764874,
0.008132578,
-0.017654775,
-0.008112726,
0.0051217373,
-0.010753002,
0.0013598411,
-0.026257176,
-0.011897783,
0.010554485,
0.011970572,
-0.036315367,
0.014055001,
-0.011183122,
0.014385862,
-0.009184718,
0.016596017,
0.019335551,
-0.0064815786,
0.0056014867,
-0.017972402,
0.02787178,
-0.0020381075,
-0.022247134,
0.00635916,
0.00092972105,
0.0036030826,
-0.008814152,
0.021069266,
0.017098928,
-0.0008536229,
-0.010858878,
0.012658765,
0.00052234775,
0.014121173,
-0.0035931568,
0.021929506,
0.008092875,
0.019070862,
-0.017681243,
0.021770693,
-0.02985695,
-0.018091511,
0.0038975496,
-0.02084428,
-0.031947996,
0.0183562,
0.006349234,
0.015973998,
-0.011467663,
0.0023871665,
-0.026574804,
-0.0026584729,
0.02318678,
-0.02318678,
0.039756328,
0.024946963,
-0.008589167,
-0.016807768,
-0.0037420446,
-0.16664837,
0.013141822,
0.012400692,
-0.0077421614,
0.03234503,
-0.019534068,
0.01713863,
0.025476342,
-0.010488313,
-0.008304626,
0.01592106,
0.004625445,
-0.0030770127,
-0.0014938401,
0.0010885346,
0.0009967205,
0.00085445005,
0.017840058,
0.017350381,
0.002770966,
0.010991222,
-0.0014268407,
0.02282945,
-0.03676534,
-0.0071135242,
-0.010673595,
-0.0070076487,
-0.0071135242,
0.0029794087,
-0.0037255015,
-0.016463673,
-0.012625678,
0.018237092,
-0.00018373158,
-0.000808543,
0.01185808,
-0.0005124219,
0.0043971506,
0.014915241,
0.023822034,
0.015722543,
0.02137366,
-0.0036494033,
-0.007656137,
-0.031895056,
0.021135438,
0.009707479,
-0.009707479,
0.026071893,
0.0042217937,
0.021691285,
-0.010316265,
-0.007967147,
0.037427064,
0.014650552,
0.030730424,
-0.011275763,
0.009733948,
0.020672232,
-0.0009545357,
-0.0063161477,
0.0066635525,
0.01467702,
0.01850178,
-0.0069480934,
-0.0136314975,
0.0104486095,
0.005247465,
-0.021281017,
0.034886047,
-0.032477375,
-0.012261731,
-0.006822366,
-0.0054426733,
0.018210622,
0.002734571,
-0.012116152,
0.012758023,
0.0023110681,
0.025568984,
0.010554485,
0.007523793,
-0.0067826626,
-0.013300636,
0.012420544,
0.033430256,
-0.0032275547,
0.003411183,
0.010428757,
-0.018422373,
-0.0022415873,
-0.0343302,
0.02206185,
-0.018832643,
0.00296452,
0.026164535,
0.014743192,
-0.010322882,
0.0062830616,
-0.007192931,
0.019732585,
-0.0077884817,
-0.0034409605,
0.01369767,
0.015497557,
0.013975593,
0.009740565,
0.0047213947,
0.033271443,
-0.007993616,
-0.009687628,
-0.0020281815,
0.007795099,
0.018435609,
-0.011811758,
0.0011456083,
0.0124337785,
-0.009409703,
-0.0031547653,
-0.03133921,
0.06484887,
0.012241879,
-0.010911815,
0.01876647,
0.0094560245,
-0.038194664,
-0.11953367,
-0.020195791,
0.014756427,
-0.0006886057,
0.01257274,
0.020328136,
-0.0038545376,
0.025489576,
0.0018958369,
0.028295284,
-0.019520834,
-0.0073451274,
0.0026038808,
0.0025707947,
0.028030595,
0.00604815,
-0.0032077031,
-0.027077712,
-0.019785523,
0.04467955,
-0.018316498,
0.0004094412,
0.002287908,
-0.02440435,
-0.018409139,
-0.0132344635,
-0.0108390255,
0.014650552,
-0.005945583,
0.02861291,
0.038300537,
0.01271832,
0.01417411,
-0.0025989178,
-0.034489013,
-0.00437399,
0.0084634395,
-0.026058659,
0.03721531,
-0.036924154,
0.0018925283,
0.0034773552,
0.025926314,
-0.0026717074,
0.009436172,
-0.012294817,
-0.025926314,
-0.0055452404,
-0.00296452,
-0.0063790116,
-0.015471088,
-0.0057040537,
-0.023041202,
-0.007087055,
0.019917868,
-0.017482726,
0.017006285,
0.0073186583,
-0.034621358,
-0.0076098167,
-0.004400459,
0.00015829659,
-0.021016328,
0.022604464,
0.0044401623,
-0.020486949,
-0.010858878,
-0.029433448,
0.0092442725,
-0.022895621,
-0.030703956,
-0.011083864,
-0.00999202,
-0.011341935,
-0.017310679,
0.002100971,
-0.014809364,
-0.015960762,
-0.004764407,
0.01687394,
-0.01701952,
-0.010203771,
0.017098928,
-0.018607656,
-0.0036063914,
0.023822034,
0.004936455,
0.011328701,
-0.0017022829,
-0.006041533,
-0.0102567095,
-0.011692649,
0.004043129,
0.010693447,
0.011150036,
-0.008953115,
-0.011269146,
-0.006021681,
0.012341137,
0.0023425,
-0.014809364,
-0.0335626,
-0.05113797,
0.015828418,
0.014002062,
0.0013052489,
-0.012083066,
-0.021797162,
0.039174013,
-0.009191335,
0.008317861,
0.0007932407,
-0.035971273,
0.015907826,
0.0021721064,
0.0033632081,
-0.021506004,
-0.0018114672,
0.033430256,
-0.0011671142,
0.0018296646,
0.00657422,
0.0142138135,
-0.017204802,
0.0046651484,
0.032186214,
0.014068235,
0.0035369105,
0.021664817,
0.0110507775,
-0.015881356,
0.006445184,
-0.0017585293,
-0.04015336,
0.016132811,
0.012162472,
-0.021757457,
0.0038346858,
0.012030127,
0.030571612,
0.008337712,
0.021903038,
-0.010508164,
-0.033112627,
0.013763842,
0.001950429,
0.008125961,
0.008536229,
-0.019851696,
0.025463108,
-0.013141822,
-0.017972402,
0.0218501,
-0.0017701095,
-0.030968646,
-0.03012164,
-0.026786555,
0.0112426765,
0.011368404,
0.027090946,
0.00882077,
-0.020566357,
0.04984099,
-0.016119577,
0.025449874,
0.009780268,
0.01455791,
-0.0042614974,
-0.0098398235,
0.0035865395,
0.021029564,
0.008304626,
-0.03358907,
-0.022935325,
-0.007887741,
0.012083066,
0.00659738,
0.0050853426,
-0.0102567095,
0.011520601,
-0.0058463244,
0.006253284,
0.0011580156,
0.0014888771,
-0.023888206,
0.030280452,
0.020288432,
0.0033648624,
-0.020857515,
0.055584747,
-0.016344562,
0.0036163172,
-0.03110099,
0.013869718,
0.00044418167,
0.0029727914,
0.023888206,
0.032636188,
-0.008873708,
-0.00096032576,
0.012771257,
0.028507035,
0.0059522,
0.028665848,
-0.014385862,
-0.018991455,
0.009111928,
0.028586442,
-0.023769097,
-0.016529845,
-0.0238088,
0.0029711372,
0.014531441,
0.008953115,
0.011103715,
-0.0004491446,
-0.0163975,
0.0060282983,
-0.016741596,
-0.011805141,
-0.0016452093,
0.019613475,
0.0051548234,
-0.0020381075,
0.008086258,
-0.002120823,
-0.0061441,
-0.0066701695,
0.03435667,
-0.027289463,
0.032397967,
-0.0025608686,
0.027501216,
-0.0020083298,
-0.041106243,
0.0040232767,
0.0088538565,
-0.036606528,
0.021148672,
0.013188143,
0.013882953,
0.0780304,
-0.007126759,
-0.015762245,
-0.015484323,
-0.0018842567,
0.0014417294,
-0.027262995,
0.0120367445,
0.007073821,
-0.029406978,
0.02206185,
-0.0011993733,
0.04473249,
-0.037665285,
-0.025873376,
0.010713298,
0.00669333,
0.024060255,
0.0036328603,
-0.019534068,
0.010799322,
-0.025635157,
-0.0019752437,
0.009422938,
-0.0134263635,
-0.0048239618,
0.03650065,
-0.026111597,
-0.013896187,
-0.052196726,
-0.01147428,
-0.0013821743,
-0.037850566,
-0.012268348,
-0.0014309763,
-0.013294019,
0.014002062,
0.000025900259,
-0.004393842,
0.013108736,
-0.018792938,
0.032927345,
-0.029274633,
-0.02531753,
-0.024245538,
-0.024721978,
-0.013333722,
0.0051879096,
-0.0027478056
] |
Over the years, methods of cytogenetic analysis evolved and became part of routine laboratory testing, providing valuable diagnostic and prognostic information in hematologic disorders. Karyotypic aberrations contribute to the understanding of the molecular pathogenesis of disease and thereby to rational application of therapeutic modalities. Most of the progress in this field stems from the application of metaphase cytogenetics (MC), but recently, novel molecular technologies have been introduced that complement MC and overcome many of the limitations of traditional cytogenetics, including a need for cell culture. Whole genome scanning using comparative genomic hybridization and single nucleotide polymorphism arrays (CGH
|
[
-0.019741064,
0.019987019,
0.032025833,
-0.033346217,
-0.023766948,
0.013488648,
0.009385096,
-0.008485422,
-0.020116469,
-0.0053980486,
0.000025991054,
0.0006375393,
0.0058964295,
0.0074239345,
0.0019012911,
0.014226511,
0.048181143,
-0.003572809,
-0.0026585711,
-0.0073268474,
-0.03590932,
0.037100255,
-0.0026941698,
-0.02095789,
-0.0069902786,
0.06156623,
0.017941715,
-0.044090535,
0.0008656942,
0.0019724884,
0.011760497,
0.016867284,
-0.0027168235,
-0.029825188,
-0.01957278,
-0.011961143,
0.024931993,
-0.0040194103,
0.0178511,
-0.009896422,
0.007055003,
0.00001544799,
-0.0014579261,
-0.019585725,
-0.003423942,
0.0018122945,
-0.005152094,
0.000330501,
-0.012524249,
0.011514542,
-0.0036957862,
0.00046318685,
-0.028556582,
0.0051035504,
-0.008239468,
-0.033708677,
-0.004404523,
0.020168249,
0.0017135891,
-0.015676348,
-0.01946922,
0.0008527493,
-0.009035583,
0.018200614,
-0.0017200616,
-0.019042037,
0.013462759,
-0.0007370537,
-0.014148842,
-0.011359203,
0.0292815,
0.03549508,
-0.001860838,
0.00111893,
0.017812265,
-0.030938456,
-0.01811,
0.0002688102,
-0.02630416,
0.005553388,
0.0043721604,
-0.009656941,
0.01923621,
0.017126182,
0.006003225,
0.0035501553,
-0.014847869,
-0.0025533934,
0.02116501,
0.0017313884,
-0.002546921,
0.03637534,
0.014084117,
0.0034207057,
-0.013197387,
0.022459505,
0.0052653626,
0.027106747,
0.009585743,
-0.015741073,
-0.013812273,
0.0140193915,
-0.0039967564,
-0.018627798,
-0.023443323,
-0.01205823,
0.030653667,
0.0023349472,
0.010705482,
-0.025851086,
-0.023741057,
0.022368891,
0.0026601893,
-0.0121164825,
0.038187634,
-0.012349492,
0.005365686,
-0.0070032235,
-0.01638832,
0.0020388311,
0.0056051677,
0.010880239,
0.021100285,
-0.013773438,
0.033346217,
0.006647237,
-0.03870543,
-0.013631043,
-0.011540432,
-0.0159223,
0.012951433,
-0.0033203822,
0.0142394565,
0.027520986,
-0.01242069,
-0.00978639,
-0.0004368924,
0.0018656924,
-0.0050841332,
-0.03950802,
0.018770192,
0.032129392,
-0.0071779806,
-0.006410992,
-0.019132651,
0.029902859,
0.0075922194,
0.024491865,
0.018653687,
-0.015016153,
0.0051553305,
-0.013928778,
0.026537169,
-0.008491894,
0.007456297,
-0.0019919057,
0.0070096957,
0.007669889,
-0.04214879,
0.0072232876,
-0.0060614776,
0.023896396,
0.011605157,
0.021618083,
-0.000930419,
0.02121679,
-0.013009685,
0.00032524212,
0.009715193,
-0.024336526,
-0.004003229,
0.020647211,
-0.013592208,
0.013003212,
-0.025190894,
-0.014032337,
-0.0025825195,
0.0017071166,
-0.022355946,
-0.017760485,
-0.0016359193,
0.015999971,
0.004598697,
-0.010349495,
-0.004948211,
0.0010469237,
0.028711922,
0.011100303,
-0.015598677,
-0.0056278217,
-0.005702255,
0.0026181182,
0.0035631002,
-0.008161797,
-0.63668495,
-0.00725565,
-0.0053462684,
-0.03593521,
0.0037410934,
0.018731358,
0.017307412,
0.0072880127,
-0.013540428,
0.018394789,
-0.024310635,
0.026718399,
0.0034174696,
-0.0318446,
-0.027106747,
-0.037281487,
-0.017061457,
-0.03231062,
0.028660143,
0.0039773392,
-0.038627762,
0.007184453,
-0.0035275016,
0.007831701,
-0.015961137,
0.018433623,
0.039922256,
0.017048514,
0.010200629,
0.043883417,
-0.028220013,
0.013656933,
-0.030446546,
-0.007948206,
0.054575954,
0.014291236,
-0.008789628,
0.018304173,
0.02925561,
0.020673102,
-0.0040194103,
-0.016932009,
0.022588955,
0.028686032,
-0.031430364,
0.021993488,
0.0046084058,
-0.021307405,
0.0003889556,
-0.0013179588,
-0.0034951393,
0.0013438486,
-0.0054368833,
-0.00533656,
0.004233002,
0.00005688703,
0.010245936,
-0.022213552,
0.021967597,
0.009313899,
-0.007682834,
0.018809028,
-0.006763742,
-0.020750772,
-0.0077281413,
0.027987003,
-0.0034433594,
-0.0031213535,
0.0014077644,
0.0036731325,
0.025385067,
0.03290609,
-0.015521008,
-0.0027394772,
0.021682808,
0.0328802,
0.0063689207,
-0.0069384985,
-0.00018042038,
0.00819416,
0.0014603534,
-0.00164401,
-0.034200586,
0.021786368,
0.028660143,
0.0048705414,
-0.03549508,
0.020893166,
0.0121164825,
-0.009177977,
-0.0021812257,
-0.00058252324,
0.005275071,
-0.04789635,
-0.0068090493,
0.0076634167,
-0.007909371,
-0.0015962754,
-0.00022673907,
-0.030886674,
-0.037695725,
-0.010200629,
-0.0010525871,
0.017553367,
-0.004896431,
0.008019403,
-0.021682808,
-0.004035591,
0.040595394,
-0.018770192,
0.0075080767,
-0.011922308,
-0.009281537,
-0.019145597,
0.026899626,
-0.021618083,
-0.0015266963,
0.027262086,
-0.017967604,
-0.02111323,
0.009300954,
0.0035598641,
-0.0007576847,
-0.028763702,
0.002333329,
-0.006242707,
0.017501587,
-0.00369255,
0.006466008,
-0.03303554,
0.005135913,
-0.02006469,
0.007430407,
-0.01800644,
0.018990256,
-0.01471842,
0.018601907,
0.0014004828,
-0.01939155,
-0.006970861,
-0.033760455,
-0.016090585,
-0.0062362347,
0.030809006,
-0.0031359165,
0.009126197,
-0.037540384,
-0.009728137,
0.014097062,
0.007022641,
-0.020608377,
0.0146148605,
-0.0019433622,
0.02938506,
0.016543658,
-0.012194153,
0.0027669852,
-0.029876968,
0.007184453,
-0.045229692,
0.018433623,
0.0068284664,
-0.0075986916,
-0.00036144757,
0.005731381,
-0.011728134,
-0.02440125,
0.0042524193,
-0.0053495048,
-0.020388313,
0.00070995017,
-0.017229741,
-0.0295404,
0.001509706,
0.0034595407,
0.02437536,
-0.0031245898,
0.012310658,
-0.010019399,
-0.012731369,
0.010899656,
-0.024867268,
-0.025475683,
-0.01587052,
0.023987012,
0.01489965,
0.013838163,
-0.0036504788,
0.028556582,
0.033838127,
-0.013592208,
0.017786376,
-0.017346246,
0.00046116422,
0.001388347,
-0.0033883434,
-0.006847884,
0.015132658,
-0.0018656924,
0.060478855,
0.03303554,
-0.00994173,
0.0103236055,
0.0018770192,
0.016349485,
-0.034330033,
0.008122963,
-0.011760497,
-0.012122955,
-0.008161797,
0.0019886696,
0.013941722,
0.0011019397,
0.003880252,
0.0047249105,
0.00887377,
-0.026666619,
-0.0012176353,
-0.004514555,
0.011980561,
-0.0068025766,
-0.0068155215,
0.039818697,
0.018537182,
0.0007860018,
0.014084117,
-0.002239478,
0.016582495,
0.010485418,
0.0024999955,
-0.013566318,
0.020297697,
-0.012621337,
0.013158552,
0.014627805,
0.023754003,
0.003870543,
-0.020919057,
0.03645301,
0.008213577,
-0.013812273,
-0.0001384504,
0.03326855,
-0.0005865685,
0.016168255,
-0.0012855964,
0.020517763,
0.015896412,
-0.017889936,
-0.0076116365,
-0.006834939,
0.003153716,
-0.024776654,
-0.0005291253,
0.0019449802,
-0.013184442,
0.0143947955,
0.012478942,
0.044530664,
0.015171493,
-0.0008252412,
-0.021501578,
-0.019844623,
-0.015326833,
-0.001631874,
0.022355946,
0.03987048,
-0.010135904,
-0.010174739,
0.012601919,
-0.027287977,
-0.01623298,
0.014420685,
-0.009728137,
0.0034530682,
-0.011915836,
0.0042686006,
0.028453022,
0.027520986,
0.009113252,
-0.02429769,
-0.03277664,
0.01777343,
0.024944939,
-0.012168263,
-0.025126169,
-0.003113263,
0.009255647,
-0.034977283,
-0.008071182,
0.0046213507,
-0.01779932,
0.008711958,
-0.0100129265,
-0.00832361,
-0.01805822,
0.012737841,
0.011152083,
0.01049189,
0.019313881,
-0.003278311,
0.021514524,
-0.015650457,
0.003129444,
0.044116426,
0.015572787,
-0.0049935183,
-0.008038821,
-0.020051744,
-0.026239434,
-0.007618109,
-0.021449799,
-0.0057766885,
-0.011702244,
-0.012763731,
0.015754016,
0.0010744317,
0.004663422,
0.00058940024,
0.0031585703,
-0.020375367,
-0.027184416,
-0.022433616,
0.0039449767,
0.03228473,
0.03295787,
-0.01597408,
0.015521008,
-0.015831687,
0.023275038,
-0.0033495084,
-0.017734595,
0.023611607,
-0.0145501355,
0.004203876,
-0.0036310614,
0.018343009,
0.00221197,
-0.0051262043,
0.01936566,
-0.0056601837,
0.009618105,
-0.00796115,
0.0140193915,
-0.002344656,
-0.012906126,
0.044996683,
0.044401214,
0.006737852,
0.0012499978,
0.0009999982,
0.012763731,
-0.0075080767,
-0.010983799,
-0.024543645,
0.030265316,
-0.0029999944,
0.016608384,
-0.0035048479,
0.003019412,
0.008343027,
-0.008135907,
-0.01148218,
-0.023559827,
0.025165003,
0.00008753018,
0.02897082,
-0.0077993385,
-0.0025598658,
0.00010340798,
0.017449806,
-0.001225726,
-0.026640728,
-0.020245917,
0.01620709,
-0.015313888,
-0.0047961078,
-0.015961137,
0.017605146,
0.010427166,
-0.024155296,
-0.006362448,
-0.0037087312,
0.0061941636,
0.0015129423,
-0.018394789,
0.00725565,
-0.012103538,
-0.017165016,
-0.0062977234,
-0.022381837,
-0.020660156,
-0.02907438,
-0.014174731,
0.0055048442,
-0.03572809,
-0.02293847,
-0.012679589,
0.025864031,
0.019223265,
0.015106768,
-0.010122959,
-0.01962456,
0.04903551,
-0.020207083,
-0.01489965,
-0.005530734,
-0.035184402,
-0.004961156,
-0.012362437,
0.00045469173,
0.0035533917,
-0.011566322,
0.027029077,
-0.027080856,
-0.016142365,
-0.0073980447,
0.0065954574,
-0.0010995126,
0.008582508,
-0.0012799329,
0.018977312,
-0.010349495,
-0.031456254,
0.008608399,
-0.038109962,
-0.011689299,
-0.020142358,
-0.007022641,
-0.0066795996,
-0.03847242,
0.0051391493,
-0.0012467615,
0.0014765345,
-0.0018220032,
-0.047352664,
-0.002291258,
0.015365668,
0.025902865,
0.022744294,
0.010517781,
0.020323588,
0.019300936,
-0.012796093,
0.010226519,
-0.008407752,
0.008608399,
0.0011367294,
-0.015818741,
0.024090571,
-0.0043462706,
-0.02948862,
-0.021695754,
-0.009223284,
-0.02280902,
0.040103488,
-0.021592194,
-0.009132669,
-0.013643988,
0.0063430304,
-0.0014975701,
0.020297697,
0.0149255395,
0.00604206,
-0.00007756863,
0.018524239,
0.0061650374,
-0.011197391,
0.019080872,
-0.039715137,
-0.010809042,
0.03867954,
-0.012472469,
0.004417468,
-0.01993524,
0.0015938482,
-0.0025016135,
-0.00614562,
-0.0066407644,
-0.033967577,
0.00027406908,
-0.0067249066,
0.036038768,
0.028090565,
0.019171486,
-0.012796093,
0.033087317,
0.010556615,
-0.0102782985,
-0.008990275,
-0.03306143,
0.004961156,
-0.03888666,
0.0075404393,
-0.012012923,
0.0019029091,
-0.015844632,
-0.024867268,
0.01939155,
0.015210329,
-0.014252401,
-0.013592208,
0.01474431,
-0.030135868,
-0.02455659,
0.014964374,
0.0071197283,
0.00407119,
-0.025851086,
0.011585739,
0.028349463,
-0.007760504,
-0.0029983765,
-0.018174725,
0.022744294,
-0.01044011,
0.014200621,
-0.018886697,
0.015792852,
-0.009203867,
-0.020142358,
-0.014058227,
-0.0047508003,
0.011197391,
0.008511311,
0.02247245,
-0.0055695693,
-0.0159223,
-0.0035825178,
-0.0014069554,
-0.0071067833,
-0.0055469153,
0.012355965,
-0.01646599,
-0.013410979,
-0.010362441,
-0.0087961005,
-0.024737818,
0.018938476,
0.01469253,
-0.015896412,
0.017760485,
0.009779917,
-0.01082846,
0.02132035,
0.0002868118,
0.010097069,
-0.026459498,
0.011190918,
-0.010938492,
-0.0074109896,
-0.023184424,
-0.008440114,
0.011126193,
0.006951444,
0.025022607,
0.0015129423,
-0.0032831656,
-0.0046407683,
0.014524246,
-0.0037443298,
-0.02633005,
-0.03937857,
-0.010006454,
0.005456301,
0.007967623,
-0.021760479,
0.0022702224,
-0.027029077,
0.04012938,
0.0065533863,
0.0064142277,
-0.0025501573,
-0.0009878622,
0.0029676321,
0.037876952,
-0.012595447,
0.012977323,
-0.0038187632,
-0.012705479,
-0.0027718395,
-0.012407744,
-0.010990271,
0.011391565,
-0.01774754,
0.030990236,
0.0112750605,
-0.008543674,
0.014821979,
0.012355965,
-0.0012241078,
-0.028271792,
-0.025423901,
0.04012938,
-0.025410958,
0.002558248,
0.002156954,
0.02006469,
-0.0025161766,
0.003776692,
0.0014385087,
-0.021022616,
-0.02293847,
0.000053751926,
0.010731372,
0.00111893,
0.00735921,
-0.028919041,
-0.018860808,
-0.013786383,
-0.028919041,
-0.021333294,
0.030653667,
-0.040181156,
-0.014187677,
0.0044692475,
0.013210332,
0.023624552,
-0.010925546,
-0.0037928734,
-0.0057928697,
0.027572766,
0.010265353,
0.015326833,
0.013145607,
0.011035578,
-0.028116453,
0.00816827,
-0.023339763,
-0.020944946,
-0.0058802483,
-0.020323588,
-0.031792823,
-0.012925543,
0.000014891761,
0.020478927,
0.009818752,
-0.011734607,
0.0062912507,
0.016660163,
0.0159223,
-0.027987003,
-0.042796038,
0.01620709,
-0.02956629,
-0.006268597,
0.02098378,
-0.030964345,
-0.011754024,
-0.0041423873,
-0.010226519,
-0.010550142,
-0.02599348,
-0.021566303,
-0.001969252,
0.024919048,
-0.013488648,
0.011288005,
-0.008291247,
-0.00488025,
-0.009721665,
0.008679596,
0.0024757236,
0.0063851015,
-0.0028187651,
-0.016802559,
0.00029753183,
0.03174104,
-0.029747518,
-0.0027330047,
-0.009035583,
-0.008207105,
-0.05237531,
0.00728154,
-0.01946922,
0.019275045,
0.017812265,
-0.023741057,
-0.036401227,
-0.007766976,
-0.027520986,
-0.04220057,
0.02142391,
0.00015483386,
0.0009182831,
0.03943035,
0.008944968,
0.011333313,
-0.009042054,
0.013812273,
-0.0050161723,
0.00647248,
0.016789613,
0.00665371,
0.046938427,
0.0012491887,
-0.027003188,
0.005647239,
0.023520993,
-0.006834939,
-0.0074045174,
0.011721661,
0.018433623,
0.014330071,
-0.0054724817,
0.0068155215,
0.0010347877,
0.012957905,
0.012809038,
-0.018847862,
-0.0012200625,
0.0054724817,
-0.0111197205,
0.0130226305,
0.020944946,
0.005233,
-0.00074190804,
0.020647211,
-0.018265339,
-0.031378582,
0.011728134,
-0.014122952,
0.0049190847,
0.05322968,
-0.008453059,
0.016530715,
0.0012168263,
-0.0036375339,
0.018951422,
-0.009022637,
0.017333303,
-0.013501594,
-0.0064142277,
-0.010148848,
-0.009818752,
-0.00023907723,
-0.0035922264,
-0.013236222,
-0.0075080767,
-0.0049190847,
-0.03269897,
-0.019326827,
0.0037572747,
0.008595454,
0.0003033975,
-0.013967612,
0.010271826,
-0.028530693,
0.0027297684,
0.011126193,
-0.0077151963,
-0.028427133,
0.008239468,
-0.0015032336,
-0.0028300919,
0.0023349472,
-0.009339789,
0.006482189,
-0.025229728,
-0.010459528,
0.18102233,
-0.022394782,
-0.005365686,
0.013333309,
0.0012338165,
-0.027805775,
0.016867284,
0.013184442,
0.0027313866,
0.001254852,
0.032129392,
-0.0027588946,
-0.008317137,
-0.0008810664,
0.03880899,
-0.01656955,
-0.008511311,
-0.010103541,
-0.020051744,
0.0051326766,
0.017100293,
-0.021993488,
0.0109643815,
0.0011820367,
0.023106754,
-0.0027087328,
-0.0053139064,
0.018174725,
0.031922273,
0.00012722469,
-0.027753994,
0.0046342956,
-0.0016974079,
-0.009669885,
0.0010833314,
0.017721651,
0.009877005,
0.0023673095,
0.0030857548,
-0.023870507,
-0.011288005,
-0.0037961097,
0.019896405,
-0.0033236186,
0.023210313,
0.014317126,
0.0007115683,
-0.02291258,
0.010951436,
-0.030394766,
-0.03593521,
0.021540415,
0.009378624,
0.011475707,
-0.00889966,
0.001980579,
0.026317105,
-0.0037928734,
-0.011106776,
0.024673095,
-0.010783152,
-0.013579263,
-0.033423886,
0.013346254,
-0.010789624,
0.024970828,
0.0071779806,
0.0020744298,
0.023365654,
-0.008880243,
0.0006840602,
-0.0007831701,
-0.0063948105,
0.0072168154,
0.0060452963,
-0.020181194,
0.03601288,
0.030084088,
0.017410971,
-0.0035242655,
0.018964367,
0.00978639,
-0.019741064,
-0.0027184417,
-0.019313881,
-0.02948862,
0.037022587,
0.01633654,
-0.001969252,
-0.010330078,
-0.0068996637,
0.013851107,
-0.0048058163,
-0.0036893138,
0.0013891561,
0.019715175,
0.024207076,
0.0005554197,
-0.011579267,
-0.018757248,
-0.011799331,
0.06270539,
0.01933977,
0.009288009,
0.0037152036,
0.015352723,
-0.025760472,
0.0006326849,
-0.02943684,
0.009152086,
0.018834917,
-0.016025862,
0.016983788,
-0.007482187,
0.0046990206,
0.02165692,
0.018524239,
-0.0590808,
0.025773415,
0.009650468,
-0.003951449,
-0.012880236,
0.009423931,
0.012407744,
-0.011715189,
0.0012063085,
-0.008608399,
0.008576036,
-0.018045275,
-0.021799313,
-0.018731358,
0.00033616443,
-0.011229753,
0.013773438,
0.007682834,
-0.0031067904,
-0.0013495121,
-0.004352743,
-0.037048478,
-0.0066245836,
0.008084128,
-0.002953069,
0.006514551,
0.037928734,
-0.010944963,
-0.019508054,
0.011210335,
0.01297085,
-0.020854332,
-0.035054952,
-0.010498363,
-0.024621315,
-0.01751453,
-0.01453719,
0.027365645,
-0.017618092,
-0.002372164,
-0.0027459497,
0.009456294,
-0.004084135,
-0.027598655,
0.015171493,
0.0349255,
0.001495952,
0.010019399,
-0.013003212,
-0.16031039,
0.00036609964,
0.0035501553,
-0.025682801,
0.013954667,
0.005828468,
0.013760493,
-0.018226504,
-0.0065113152,
0.0076957787,
0.024207076,
0.003987048,
-0.03883488,
-0.01135273,
0.017475696,
0.0042394744,
-0.020906111,
0.055766888,
0.00978639,
0.009197394,
0.013760493,
-0.004961156,
0.03883488,
0.0059708627,
0.0017135891,
0.023054974,
-0.0017135891,
0.0043656877,
-0.015054989,
-0.023456268,
-0.008084128,
-0.01294496,
0.0038867244,
0.00923623,
0.009449821,
-0.007631054,
-0.015300943,
-0.0049417387,
-0.0020291226,
-0.0103236055,
0.031093795,
0.024517754,
0.025113223,
-0.010511308,
0.006255652,
0.045100242,
0.010744317,
-0.031896383,
0.01954689,
-0.004576043,
0.025682801,
0.008174743,
0.0042653643,
-0.0041229697,
0.035054952,
0.0050776605,
0.0034692492,
0.004491901,
0.006135911,
0.007469242,
-0.0035501553,
-0.018368898,
0.0051294407,
-0.007883481,
-0.010498363,
-0.019262102,
-0.018355954,
0.018860808,
-0.023533938,
-0.0035372104,
-0.0072232876,
0.019119706,
0.025048498,
-0.015482172,
0.03906789,
0.013210332,
-0.0036601876,
0.015495118,
0.0011124575,
-0.020129412,
-0.031585705,
0.0039708666,
-0.012284767,
-0.018122945,
0.006090604,
0.0105889775,
0.012511304,
0.0030388294,
-0.017449806,
0.0065469136,
0.017126182,
-0.030550105,
0.012349492,
-0.030757226,
0.030032307,
0.0050517707,
-0.013113244,
-0.010504835,
0.014860814,
-0.016996732,
0.020996725,
7.5375317e-7,
0.0057993424,
0.0018818736,
0.027676325,
-0.00025121315,
0.011728134,
0.0240129,
0.033915795,
0.00077831576,
-0.030886674,
0.002184462,
0.015987026,
0.017203853,
0.00061974,
0.030524217,
-0.0020064688,
0.003721676,
-0.0030339751,
-0.00735921,
0.078084,
-0.023508048,
-0.00816827,
0.025695747,
-0.011682827,
0.008058238,
-0.13980557,
-0.013249167,
-0.0103236055,
0.0075404393,
-0.002977341,
0.01664722,
-0.021152064,
0.02147569,
0.00085679453,
0.036038768,
-0.04566982,
-0.022343002,
-0.013359199,
-0.019922294,
0.00030420657,
0.0021957888,
0.0012977322,
-0.0021747532,
-0.013080882,
0.026925517,
0.012647226,
-0.010349495,
-0.028737811,
-0.010524252,
-0.01299674,
0.004110025,
-0.0393009,
0.018744303,
0.0051618028,
0.014472466,
-0.0030582468,
-0.017708706,
0.027572766,
-0.006699017,
0.0012540431,
-0.012355965,
-0.005996753,
-0.037514497,
0.037851065,
-0.00733332,
-0.011126193,
0.026588948,
0.021398019,
-0.006750797,
0.018317118,
-0.0028381825,
-0.020724881,
0.005165039,
0.019896405,
-0.017320357,
-0.023417434,
-0.016634274,
-0.02124268,
-0.009792862,
0.016660163,
-0.025242673,
0.00046278234,
-0.011359203,
-0.023663387,
0.0038187632,
-0.019313881,
-0.0043592155,
0.00528478,
0.014278291,
0.010951436,
-0.013035575,
-0.014200621,
-0.03513262,
0.022355946,
-0.03194816,
-0.002236242,
0.0053009614,
-0.027753994,
-0.011268588,
-0.012258877,
0.017475696,
-0.031508032,
0.0069902786,
0.017294466,
-0.007055003,
-0.026821958,
-0.008906133,
0.021566303,
-0.018135889,
0.050770134,
0.010809042,
-0.0012872145,
-0.022148827,
0.017255632,
-0.0025258854,
0.0033753985,
0.034459483,
-0.017812265,
-0.025643967,
-0.013669878,
0.015042044,
0.0055598603,
0.0009118106,
0.022368891,
0.04639474,
-0.027702214,
-0.005906138,
-0.04888017,
0.01208412,
0.009585743,
0.013210332,
0.0033106736,
-0.01787699,
0.008491894,
-0.0036148801,
0.012407744,
0.028375354,
-0.023352709,
0.008718431,
-0.020038798,
-0.0077151963,
-0.023378598,
-0.024414195,
0.013812273,
0.005498372,
0.021825204,
0.028220013,
0.01474431,
-0.004734619,
0.03502906,
0.034563042,
0.008647233,
-0.0027944932,
-0.00725565,
0.013410979,
-0.0065663313,
-0.017281521,
0.03893844,
-0.011786386,
-0.0024983773,
-0.008595454,
-0.015689291,
-0.0071520903,
-0.015883466,
0.028142344,
0.023728112,
0.060685974,
-0.018148834,
0.0019643977,
0.018912587,
-0.007184453,
-0.026213545,
0.006996751,
-0.038990222,
0.017682815,
0.0012766967,
-0.00009294077,
0.024491865,
-0.0067896317,
0.010718427,
-0.046783086,
-0.012588974,
-0.00288349,
-0.004718438,
-0.0023171478,
-0.005647239,
-0.022679571,
0.028737811,
0.020271808,
0.01226535,
-0.018796083,
-0.024543645,
-0.016621329,
-0.018148834,
0.008789628,
0.003129444,
-0.028168233,
-0.018653687,
0.029902859,
0.0068284664,
0.009766973,
-0.007559857,
-0.0014457903,
-0.0042686006,
0.015987026,
0.013158552,
-0.0046569495,
0.008388334,
0.02242067,
-0.020375367,
0.0076957787,
0.019689284,
-0.018821971,
-0.0011391565,
0.01458897,
-0.0065728035,
0.0043074354,
-0.0076375264,
0.009656941,
0.000095165684,
0.030653667,
-0.01829123,
0.0045469175,
-0.0017588965,
0.018420678,
0.009197394,
0.03306143,
-0.009766973,
-0.015999971,
0.019249156,
-0.011540432,
-0.019171486,
0.01044011,
-0.021708699,
-0.030705446,
0.009190922,
0.029721629,
0.015999971,
0.006443354,
0.013294474,
-0.01291907,
-0.018576019,
-0.0058317045,
0.0050841332,
-0.0077087237,
-0.013398034,
0.02450481,
0.001361648,
0.006336558,
0.006970861,
0.0011067941,
0.026977297,
0.010731372,
0.017281521,
-0.016893173,
0.0065889847,
0.007268595,
0.023443323,
-0.0075145494,
-0.034433596,
0.005851122,
0.0051391493,
-0.015715182,
0.015443337,
0.00093365525,
-0.012207097,
0.07388984,
0.01756631,
-0.008886715,
0.001092231,
-0.01941744,
0.02956629,
0.015987026,
-0.0075274943,
-0.007236233,
-0.03953391,
0.028271792,
-0.026718399,
0.018614853,
-0.010330078,
-0.023508048,
0.020401258,
-0.00040129377,
-0.0014474083,
-0.011307423,
-0.00024595426,
0.021255625,
-0.00793526,
0.01787699,
0.033501558,
-0.011546904,
-0.0058414135,
0.03821352,
-0.008919078,
0.019766955,
-0.008310664,
-0.0076245815,
-0.026977297,
-0.036893137,
-0.01471842,
-0.00026739432,
-0.018459514,
0.0067896317,
-0.027961114,
0.012407744,
0.02106145,
-0.0060452963,
0.010498363,
-0.00647248,
-0.0051035504,
-0.01474431,
-0.001941744,
0.00084870396,
-0.019067926,
-0.0066245836
] |
Genome-wide association studies (GWAS) have now identified at least 2,000 common variants that appear associated with common diseases or related traits (http://www.genome.gov/gwastudies), hundreds of which have been convincingly replicated. It is generally thought that the associated markers reflect the effect of a nearby common (minor allele frequency >0.05) causal site, which is associated with the marker, leading to extensive resequencing efforts to find causal sites. We propose as an alternative explanation that variants much less common than the associated one may create "synthetic associations" by occurring, stochastically, more often in
|
[
-0.031968575,
0.005013135,
0.009179811,
-0.035091944,
-0.037112944,
0.020931806,
-0.018753324,
0.01142391,
-0.024370134,
-0.0010424892,
-0.008307105,
-0.011896352,
0.009521019,
0.0036614256,
0.013740188,
0.033464644,
0.028661482,
-0.019501356,
0.001761815,
-0.016745444,
-0.027244156,
0.012276931,
-0.013189006,
-0.030525003,
0.0058759977,
0.04832032,
0.0092060575,
-0.015393736,
-0.022126034,
0.007755923,
0.009055139,
-0.00014046127,
-0.032126058,
-0.0031742197,
-0.0010162424,
-0.00995409,
0.0062664184,
-0.010898975,
0.00592521,
-0.028399015,
-0.016719198,
0.017454108,
0.00902233,
-0.0035695618,
0.001958666,
-0.0062664184,
0.029133923,
-0.016929172,
-0.011003962,
0.020839943,
0.00708663,
0.033359654,
-0.025420005,
0.0050984365,
0.00073039863,
-0.007847787,
0.015734944,
0.009658814,
-0.010078763,
-0.02439638,
-0.01719164,
-0.0071850554,
-0.032231044,
0.0033267792,
-0.03120742,
-0.0038287488,
-0.018241512,
0.01808403,
0.017375367,
0.0058530318,
0.033149682,
0.02024939,
0.0052329516,
-0.0152231315,
0.010459341,
-0.024868822,
0.001943902,
0.014448851,
-0.023727087,
0.019028915,
0.014042026,
0.0077493615,
0.0033087344,
0.0073359744,
0.013208691,
-0.0052395132,
0.0043930546,
0.009475087,
-0.016391113,
-0.011482965,
-0.008129939,
-0.002601712,
-0.019330753,
-0.0032119495,
-0.0012450815,
0.0093044825,
0.015183762,
0.001177004,
0.0022375379,
-0.019199518,
-0.012303177,
0.0069750813,
-0.011371417,
-0.010879289,
-0.012650947,
0.006459988,
0.0020603721,
-0.006486235,
-0.025288772,
-0.0068832175,
-0.012979032,
0.029475132,
-0.017493477,
-0.013221814,
0.016876679,
-0.013057772,
0.024934439,
-0.009225743,
0.004757229,
-0.009179811,
0.040630013,
0.010662754,
0.032729734,
0.0075525106,
0.002915033,
0.015275625,
-0.03356963,
0.02776909,
-0.014291371,
-0.013024963,
0.0329922,
0.018254634,
0.03128616,
0.0030036157,
-0.037139192,
-0.003589247,
-0.0026394418,
-0.0029330775,
-0.01479006,
-0.02578746,
0.019055162,
0.03333341,
-0.028950196,
0.0036614256,
0.0053609046,
0.043464664,
0.014671949,
-0.0044783563,
0.016797937,
-0.0049245516,
0.0035170682,
0.015498723,
0.021443618,
0.005551194,
-0.00083005434,
0.0003430536,
0.024461998,
0.02272971,
-0.05068253,
-0.011194251,
0.0047408245,
0.0010465903,
-0.008254612,
0.026850455,
0.015419982,
0.023530237,
-0.0042880676,
-0.0113058,
0.003973106,
-0.015183762,
-0.034357034,
0.031417392,
-0.045984354,
0.021863567,
0.004885182,
0.010209997,
0.000029681416,
0.018700829,
-0.015997412,
-0.019409493,
-0.009671938,
-0.0016420641,
0.029317651,
-0.005551194,
-0.017283503,
0.00236221,
0.028320273,
-0.004858935,
0.003782817,
-0.03209981,
0.0023802547,
-0.0011138477,
-0.014842553,
-0.002075136,
-0.63832164,
0.0052952874,
-0.01049215,
-0.030262535,
-0.003996072,
0.028713975,
0.005780853,
0.0138976695,
-0.022296637,
0.035774358,
-0.012611577,
0.010433095,
0.016023658,
-0.0071456856,
-0.020472487,
-0.033018447,
0.005262479,
-0.026378011,
0.0419686,
0.014619456,
-0.02505255,
0.012611577,
0.0043339995,
-0.0018651617,
0.0018126682,
0.022099787,
-0.0014632579,
-0.030026315,
-0.005292007,
0.01943574,
-0.016889801,
0.009809733,
-0.019737577,
0.028057806,
0.0501051,
-0.0038156253,
0.018792693,
0.029868834,
0.020459363,
0.035748113,
-0.016246757,
-0.0029904924,
0.021745456,
0.016128646,
-0.0091535635,
0.032204796,
0.0029675264,
0.02171921,
0.0058071,
-0.04692924,
0.0053182533,
0.011430472,
-0.010190312,
-0.014619456,
0.009002645,
0.004465233,
0.026102422,
-0.01730975,
0.010000022,
0.0034612939,
-0.014002657,
0.0064140563,
0.014842553,
-0.0037532893,
0.0041437102,
0.019540727,
0.0027821586,
0.01923889,
0.015748067,
-0.008569573,
0.009094508,
0.03443577,
0.0010605339,
-0.022231022,
0.0048654964,
0.024488244,
-0.008451463,
0.032021068,
-0.030839965,
0.012276931,
-0.018963298,
-0.013464597,
-0.01401578,
0.0069947666,
0.00216864,
0.022231022,
-0.015078774,
-0.0042454163,
-0.001699479,
-0.01266407,
0.0075131403,
0.0012541038,
-0.02106304,
-0.043307185,
-0.014278247,
0.024304517,
-0.013950163,
0.020774325,
0.01506565,
-0.003953421,
-0.023740212,
-0.02017065,
-0.0052296706,
0.007093192,
0.024028925,
0.021076163,
-0.01901579,
0.0065682563,
0.022165405,
-0.020262513,
0.008458024,
0.011364855,
-0.006706052,
-0.005521666,
-0.00077961135,
-0.030288782,
-0.003070873,
-0.00087188516,
-0.019291382,
-0.04173238,
0.03070873,
0.023818951,
-0.00302002,
-0.018359622,
0.010419971,
-0.006338597,
-0.017099775,
-0.032047316,
0.0025820269,
-0.015669327,
0.021128656,
-0.02675859,
0.017782193,
-0.0037893786,
-0.01792655,
-0.03732292,
0.007053822,
0.0056036874,
-0.010242805,
-0.029265158,
-0.0043536844,
0.00023478564,
0.007178494,
-0.0040715314,
-0.03519693,
-0.006358282,
-0.020183772,
-0.012047271,
0.0023097165,
-0.017637836,
0.027559116,
-0.0107349325,
-0.013963286,
0.020826818,
-0.00914044,
-0.0005626653,
0.00057496846,
-0.023097165,
0.0015813684,
-0.007388468,
0.005308411,
-0.004019038,
-0.0039632637,
-0.016784815,
0.012683756,
-0.019330753,
-0.016745444,
0.02288719,
-0.03322842,
-0.02532814,
0.02826778,
-0.040735,
-0.0031807814,
0.023333386,
0.016312372,
0.021351755,
-0.0064796736,
-0.0019455424,
0.001773298,
-0.02265097,
-0.014593209,
-0.029107677,
-0.021706086,
-0.016719198,
0.026207408,
0.008602382,
0.028215287,
-0.0070144515,
0.015708696,
0.009094508,
-0.01142391,
0.016666705,
-0.01490817,
0.023294017,
0.010439656,
0.015879301,
0.014842553,
-0.004045285,
-0.014881924,
0.015761191,
0.023372756,
-0.013405542,
0.0035498769,
-0.054540806,
0.032047316,
-0.04015757,
0.01629925,
-0.015262501,
-0.016351743,
0.0029019094,
-0.0011154881,
-0.010793988,
0.00321359,
0.008398969,
0.011916038,
-0.0060334783,
-0.009055139,
0.00014497244,
0.00082021183,
0.00069061836,
0.011692939,
0.007040698,
0.030026315,
0.00029240552,
-0.005866155,
-0.007040698,
0.0066765244,
0.02060372,
0.0039895102,
-0.0113058,
-0.0076903063,
0.0017880618,
-0.002915033,
0.0014099441,
0.01188979,
-0.0064370222,
-0.0152231315,
-0.019868812,
0.028766468,
0.02125989,
-0.0053445003,
-0.014960663,
-0.00016014636,
-0.016561717,
0.022322886,
-0.0016412438,
0.03267724,
0.014475098,
-0.015813684,
0.020078786,
-0.0047506667,
0.008024952,
0.0034284855,
0.012887168,
-0.00025877682,
-0.016089275,
0.031076185,
0.0025836672,
0.037007958,
0.018871434,
0.019461986,
-0.009107632,
-0.024225777,
-0.018057784,
0.0027887202,
-0.0010310062,
0.0032316346,
-0.003287409,
-0.0010810392,
0.004150272,
-0.014068273,
-0.0100722015,
0.016509224,
-0.020105032,
-0.00031332092,
0.00468505,
0.012814989,
0.009265113,
0.023189029,
0.006706052,
-0.010984276,
-0.015761191,
0.027034182,
0.011023647,
-0.0074672084,
-0.022139158,
0.0021752017,
0.007545949,
-0.028897703,
0.0058759977,
0.005584002,
0.008608943,
0.005269041,
-0.017047282,
0.012178505,
-0.008267735,
0.03354338,
-0.0048884624,
0.016115522,
-0.016102398,
-0.0021079443,
0.0024688377,
-0.015551216,
-0.024553861,
0.014042026,
0.018346498,
-0.008576135,
-0.00352363,
0.00008196992,
-0.017979043,
0.008589258,
-0.0069488348,
0.0072900425,
-0.016692951,
-0.0014968866,
0.011207375,
-0.02249349,
0.03233603,
0.018254634,
0.0027001374,
0.018989544,
-0.042493533,
-0.0031332092,
0.00336943,
0.04774289,
0.009960652,
-0.025721842,
0.0054494874,
0.0032168708,
0.011476404,
-0.022952808,
-0.017126024,
0.018569596,
0.0026919353,
-0.010741494,
-0.003054469,
0.030315029,
0.006335316,
0.026246779,
0.021929184,
0.016430484,
-0.026614234,
-0.0129331,
0.01091866,
-0.0036187745,
-0.019173272,
0.016246757,
0.046588033,
0.015761191,
-0.018372744,
-0.00012836316,
0.0309712,
0.0045866244,
-0.011647008,
-0.019776948,
0.017834686,
-0.005862874,
0.050813764,
-0.0043110335,
-0.0028133267,
0.0022326165,
-0.0025147696,
-0.008274297,
-0.00017901123,
0.012473782,
0.0100197075,
0.018635213,
0.0309712,
0.014068273,
-0.004816284,
0.030157547,
0.0069553964,
0.013103704,
-0.014763813,
-0.0059875464,
-0.027139168,
-0.00026246777,
-0.010813673,
0.03446202,
-0.016036782,
0.008385845,
-0.0015575823,
-0.020354377,
-0.03236228,
-0.016627334,
-0.022217898,
0.009068262,
0.016404236,
-0.022572229,
-0.016246757,
-0.0047178585,
-0.031233666,
-0.023202153,
-0.015944919,
0.004872058,
-0.021312384,
-0.023385879,
-0.03094495,
0.023215275,
0.0113451695,
-0.0076181274,
0.0012442613,
0.0047145775,
0.04170613,
-0.024015803,
0.0018996106,
-0.024619479,
-0.030105054,
0.011699501,
-0.0031742197,
0.0010941626,
-0.001792983,
-0.022742834,
0.020971175,
-0.0011491168,
-0.0009760521,
0.011647008,
-0.009540704,
-0.008333352,
0.02265097,
0.016168015,
-0.0029232348,
-0.010387163,
-0.020564351,
0.00081775116,
-0.031259913,
-0.0045013223,
-0.018149648,
-0.0005474914,
-0.015301872,
-0.0010285457,
-0.010032831,
-0.0023868163,
-0.009238866,
0.005049224,
-0.023674594,
0.010689001,
0.010964592,
0.031181173,
0.015275625,
0.030262535,
0.0093569765,
-0.0037401658,
0.0049606413,
-0.006227048,
0.019383246,
0.01758534,
-0.014422605,
-0.016102398,
0.028451508,
0.011069579,
-0.0006885678,
-0.021706086,
-0.0018553191,
-0.024868822,
0.041181196,
0.0007562353,
-0.008011829,
-0.003415362,
0.0009169968,
0.005780853,
0.012565645,
-0.029448885,
-0.011935722,
-0.0031233667,
0.015616833,
-0.008812356,
-0.021273013,
0.01188979,
-0.032467265,
-0.007605004,
0.0040091956,
-0.014698196,
-0.0010580732,
0.0021538762,
-0.0016912768,
-0.019947551,
-0.030446263,
-0.0018536787,
-0.011968531,
0.007349098,
0.006315631,
0.028320273,
0.00216864,
0.025157537,
-0.0023868163,
0.020472487,
0.016522346,
0.0032972514,
-0.019028915,
-0.0056397766,
0.001192588,
-0.0020472487,
0.009225743,
0.024868822,
0.010387163,
0.00025180503,
0.007545949,
0.023674594,
0.01923889,
-0.008858288,
-0.031023692,
-0.0003941118,
-0.048110344,
-0.009468526,
0.0030036157,
0.00013974358,
0.040708754,
-0.045091964,
0.01401578,
0.023950186,
0.0074475235,
0.008563012,
0.0011491168,
0.054540806,
0.0035334725,
0.033044692,
-0.021771703,
0.02145674,
-0.038399037,
-0.023057794,
-0.014383234,
0.018648336,
0.027401637,
0.0037696934,
0.026824208,
0.0075525106,
-0.00050771114,
-0.0027345861,
0.00336943,
-0.05637808,
-0.00046629042,
-0.007027575,
-0.034330785,
0.006679805,
-0.019934429,
-0.01053152,
-0.009383223,
0.012887168,
-0.0006975902,
-0.02060372,
0.013818929,
-0.018910803,
-0.029186418,
0.0063517205,
0.01583993,
0.024252024,
-0.017165393,
0.038845234,
0.002029204,
0.002919954,
-0.040446285,
0.007650936,
0.004547254,
0.009494772,
0.020944929,
0.011049894,
-0.030078808,
-0.012224437,
0.007591881,
-0.018057784,
-0.024658848,
-0.056903016,
0.031049939,
-0.0021423933,
0.011377978,
0.00012641515,
-0.005006573,
-0.016246757,
0.017559094,
-0.013766435,
0.02060372,
0.013805806,
-0.042729754,
0.004278225,
-0.008018391,
0.016601088,
0.01177168,
-0.01297247,
-0.032703485,
-0.012762496,
-0.0016043343,
0.006292665,
0.0012130933,
0.005354343,
0.037506647,
-0.022322886,
-0.007939651,
0.01842524,
0.019343875,
0.0016174577,
-0.014645702,
-0.02675859,
0.03797909,
-0.01641736,
-0.0021817635,
0.009396346,
0.007946212,
-0.0036876723,
0.018713953,
-0.00569227,
-0.031076185,
-0.0033628684,
-0.0039140508,
0.02578746,
-0.0009063341,
0.004698173,
0.0057414826,
-0.011148319,
0.008615505,
-0.011279553,
-0.037401658,
0.038425285,
-0.040236313,
0.0077428,
-0.0085433265,
0.00487862,
0.006624031,
0.034750734,
-0.011673255,
-0.024737589,
0.007624689,
-0.012171944,
0.008320229,
0.0053805895,
-0.00003086047,
-0.011135195,
0.021128656,
-0.015406859,
-0.034671996,
-0.0060301973,
0.0061778356,
-0.017427862,
-0.035905592,
-0.0018225106,
0.0113976635,
-0.000483925,
-0.010419971,
0.020853065,
0.01413389,
0.013090581,
0.017021036,
-0.024790082,
0.028740222,
-0.01289373,
0.018175894,
0.037139192,
-0.014199507,
0.0031036816,
0.0078281015,
-0.001958666,
0.008667999,
-0.008930466,
-0.01045278,
-0.018556472,
0.026456753,
-0.0005097616,
0.01661421,
-0.0053116917,
-0.014698196,
-0.014960663,
0.018963298,
0.020380624,
-0.014238877,
-0.0062598567,
0.00782154,
0.0074672084,
0.018267758,
-0.0099212825,
-0.0062828227,
-0.01173231,
-0.013005279,
-0.042336054,
0.0074212765,
-0.017257256,
0.022664092,
0.026181161,
-0.020196896,
-0.022047294,
0.013392419,
-0.03217855,
-0.018884556,
0.009061701,
0.003438328,
0.018412115,
0.041653637,
-0.013687695,
0.02489507,
-0.015314995,
-0.0036647064,
-0.016811062,
0.0026738904,
0.00867456,
0.004268382,
0.0142520005,
0.027742844,
-0.025853077,
0.025262523,
0.031154925,
-0.0040748124,
-0.03517068,
0.01285436,
0.001010501,
0.02958012,
-0.019133901,
0.03162737,
0.0013500687,
0.00859582,
0.017532848,
-0.009671938,
-0.01909453,
-0.0018126682,
0.005921929,
-0.010964592,
0.021036793,
-0.018149648,
0.007716553,
0.01951448,
-0.03280847,
-0.0403413,
0.014593209,
0.0045308503,
0.0013804164,
0.010255929,
-0.007021013,
0.017755946,
-0.011883229,
-0.014475098,
-0.0026312396,
-0.029396392,
-0.0013574506,
0.0047801947,
-0.001142555,
0.0066043455,
-0.0155774625,
-0.00019869632,
-0.007624689,
-0.009527581,
-0.00008068834,
-0.008129939,
-0.027847832,
-0.0046456796,
0.014553838,
0.016784815,
0.015958041,
0.014750689,
-0.0076115658,
-0.038425285,
-0.009803171,
-0.0035958085,
-0.0054757344,
0.012355671,
0.017992167,
0.006204082,
-0.0065354477,
-0.009993461,
-0.008366161,
-0.010111571,
-0.03146989,
0.03333341,
0.1922314,
-0.018937051,
-0.022375379,
0.039790116,
0.023175905,
-0.019488232,
0.024829453,
-0.0006951295,
-0.013221814,
0.0040485654,
0.03146989,
-0.00014066632,
-0.028582742,
0.008845164,
0.029947573,
-0.025616856,
-0.029291404,
-0.024606355,
-0.017283503,
0.02195543,
0.03517068,
0.003093839,
-0.016076151,
-0.018438362,
0.025183784,
0.0033792728,
-0.01808403,
-0.0018389149,
-0.0034711363,
0.015118144,
-0.027585365,
0.010754618,
-0.0005339579,
0.0080315145,
-0.025000056,
-0.0015337961,
0.01142391,
-0.00070415187,
0.008477709,
0.0063123503,
0.0043077525,
0.02052498,
-0.03446202,
-0.010859605,
0.011272991,
0.0029560435,
-0.0033546663,
-0.008412093,
-0.014370111,
-0.025603732,
-0.03582685,
0.022467243,
-0.01889768,
0.022559106,
-0.0133858565,
-0.0046817693,
0.023910815,
0.0036154937,
-0.000112779126,
0.015210008,
0.00790028,
-0.0062204865,
-0.020892436,
0.021076163,
-0.02106304,
0.034671996,
-0.014435728,
0.015091898,
0.003759851,
-0.010859605,
0.016574841,
-0.026063051,
-0.013700819,
0.0013648325,
0.012034148,
-0.0020357657,
0.03566937,
0.02005254,
0.011692939,
-0.003608932,
0.0056725848,
-0.002687014,
-0.013687695,
0.008654875,
-0.0109383445,
-0.047112968,
0.019763824,
0.0058136615,
-0.019133901,
0.007198179,
-0.00890422,
-0.012303177,
-0.0023376036,
-0.02497381,
0.0030757943,
0.0021752017,
-0.0016404237,
-0.00979661,
-0.014934417,
-0.014461975,
-0.006578099,
0.058372837,
0.0009768723,
0.013687695,
-0.00013307937,
0.0045177266,
-0.0010670956,
0.0068241623,
0.02818904,
0.0098687885,
0.0042060465,
-0.0480841,
-0.00023417048,
-0.012572207,
0.005049224,
0.014698196,
0.008812356,
-0.043490913,
0.007276919,
-0.00243931,
-0.021981677,
-0.016469853,
0.01820214,
0.039790116,
-0.0004859755,
0.004324157,
-0.013713942,
-0.005931772,
-0.015262501,
-0.032021068,
0.0072900425,
-0.005390432,
0.0005060707,
-0.0009883553,
-0.0037434467,
-0.03517068,
0.003930455,
-0.02640426,
-0.02892395,
0.0010597137,
-0.011502651,
-0.007926527,
0.0011335327,
0.011528897,
0.025157537,
-0.00063074287,
-0.000012886297,
0.018713953,
-0.012670632,
0.013884545,
0.0113058,
-0.0093701,
-0.0123163005,
0.016128646,
0.004639118,
-0.0064993585,
-0.018372744,
-0.025629979,
0.013313678,
-0.00013102884,
-0.035905592,
0.029212665,
0.04089248,
0.0031742197,
0.00054257014,
0.01138454,
-0.16440982,
0.03992135,
-0.0010785785,
-0.00094816484,
0.013175882,
0.010885851,
0.023871444,
-0.00607941,
0.007965897,
-0.014042026,
0.01800529,
-0.008996083,
0.0047047352,
0.021154903,
0.0045866244,
-0.015708696,
-0.030446263,
0.03706045,
0.016010534,
0.0058825593,
0.009875351,
-0.014356988,
0.023766458,
-0.020433117,
0.019868812,
0.0045275693,
-0.007992144,
0.018385869,
-0.015433106,
-0.024566984,
-0.007847787,
-0.0048884624,
0.018385869,
-0.015866177,
-0.0062861033,
0.0005122223,
-0.008011829,
-0.009416032,
-0.004986888,
-0.0011852061,
0.04897649,
0.036876723,
0.016548594,
0.00077879115,
-0.016115522,
0.0061581503,
0.02090556,
-0.03682423,
0.0067126136,
0.0012180145,
-0.0015141111,
0.008832041,
0.016706074,
0.005784134,
0.026876701,
0.02133863,
0.004967203,
0.0053609046,
-0.002908471,
-0.035748113,
-0.0056135296,
-0.022480365,
0.028451508,
-0.0049048667,
-0.0009161766,
-0.013517091,
-0.043280937,
-0.0051246835,
-0.0079790205,
0.0058825593,
-0.022139158,
-0.021010546,
0.019409493,
-0.0018487575,
0.020839943,
0.015944919,
-0.000638945,
0.017742822,
0.0018602405,
-0.017860932,
-0.021535482,
0.020787448,
-0.019042037,
-0.008175871,
0.006916026,
-0.012992156,
0.016430484,
0.012880607,
-0.0028198883,
-0.0032660835,
-0.002598431,
-0.011095826,
-0.009514458,
-0.026194286,
0.016141769,
0.0019258574,
0.0006295126,
0.012093203,
0.008005267,
-0.006318912,
-0.0047178585,
-0.02110241,
-0.022322886,
0.0022096506,
0.04627307,
-0.022637846,
0.0128740445,
0.008300544,
0.029790094,
-0.018464608,
-0.016089275,
0.022926562,
-0.0029019094,
0.02052498,
-0.011417349,
0.03860901,
-0.0031545346,
-0.005364185,
-0.002524612,
0.010813673,
0.052677285,
-0.0131824445,
0.0073425365,
-0.00018905883,
-0.003654864,
-0.017664082,
-0.11905539,
-0.009553827,
-0.016259879,
-0.00094160315,
-0.014540715,
0.02195543,
-0.018713953,
0.021745456,
-0.016404236,
0.05695551,
-0.027244156,
-0.0203675,
-0.0020718551,
-0.0281103,
-0.010524958,
0.009566951,
-0.020236267,
-0.013766435,
-0.029396392,
0.029238911,
0.0071391235,
-0.016443606,
-0.0024540739,
-0.023057794,
0.0031807814,
-0.00096785,
-0.022204775,
0.019776948,
-0.0032775665,
0.0069882045,
0.010380601,
-0.010879289,
-0.013858299,
-0.012618138,
-0.03160112,
-0.029763848,
0.008398969,
-0.03186359,
0.0048819007,
0.011916038,
-0.00006910285,
0.013569584,
0.018320251,
-0.011548582,
-0.010925221,
0.004406178,
-0.0026378012,
0.012309739,
-0.010859605,
0.0009858946,
-0.0012721486,
-0.00886485,
-0.040944975,
-0.008293982,
-0.00067544443,
-0.013556461,
-0.01002627,
0.009593197,
0.002424546,
0.001932419,
0.018753324,
-0.011870106,
-0.013713942,
-0.006204082,
0.007303166,
-0.01780844,
-0.00041769288,
-0.021640468,
0.00851708,
-0.024422627,
-0.010761179,
0.017939674,
-0.00902233,
-0.0022588633,
-0.017769068,
0.017388491,
-0.023608977,
-0.016246757,
0.016784815,
-0.05385839,
-0.015761191,
-0.014147013,
0.01677169,
-0.035328165,
0.03209981,
0.023018425,
-0.0022424592,
0.0075721955,
-0.0025377353,
-0.029685106,
-0.017637836,
0.03372711,
-0.0054232404,
-0.0046325563,
-0.013366172,
0.016574841,
0.0058136615,
-0.005610249,
0.009685061,
0.0022408187,
-0.03682423,
-0.0025328142,
-0.030052561,
0.012552522,
0.0061581503,
-0.018372744,
0.00921262,
-0.015590587,
0.0070997537,
0.009514458,
-0.006916026,
0.0036023704,
0.0018077468,
-0.010485588,
-0.011817612,
-0.012421288,
-0.021614222,
-0.004402897,
0.023753334,
0.008753301,
0.044225823,
0.013569584,
0.009127317,
0.015997412,
0.022598477,
0.033700865,
0.002009519,
-0.0042716633,
-0.009324168,
0.018503979,
-0.03047251,
-0.025367511,
0.0061319037,
-0.0129331,
-0.00820868,
0.0050787516,
-0.003008537,
-0.007532825,
0.019173272,
0.02118115,
0.03094495,
0.046246823,
-0.04104996,
-0.013543338,
-0.00886485,
0.0018520383,
-0.011909476,
0.013727065,
-0.042414796,
0.015433106,
0.006459988,
-0.009337291,
0.02745413,
0.0018028256,
-0.00005900399,
-0.034357034,
-0.035538137,
-0.00024073217,
0.012381918,
-0.0026476437,
0.015498723,
-0.02517066,
0.018097153,
0.023175905,
0.020157525,
-0.0020669338,
-0.012053833,
-0.017204763,
0.0014968866,
0.013169321,
0.010925221,
-0.02582683,
-0.020105032,
-0.002919954,
0.013070895,
0.004849092,
0.01804466,
0.0011835657,
-0.0014960663,
-0.003720481,
0.01154202,
0.016929172,
-0.0012147337,
0.00014548507,
-0.015853055,
0.03666675,
0.030682484,
-0.025118167,
-0.013556461,
-0.009337291,
0.0009981978,
0.019763824,
-0.007834664,
0.035380658,
-0.0117060635,
0.028582742,
-0.0058103804,
0.033674616,
-0.013884545,
0.0012655868,
0.026496124,
0.008005267,
0.0077362377,
0.0164961,
-0.011916038,
-0.009580074,
-0.00971787,
-0.0016273003,
-0.033858344,
-0.022834698,
0.0032053879,
-0.0009096149,
0.029028937,
0.027401637,
-0.030288782,
-0.01967196,
-0.027349142,
0.015564339,
0.009711308,
-0.0209843,
-0.0148688,
0.011607638,
0.0047375434,
0.012867483,
-0.004084655,
0.02032813,
0.026391136,
-0.00522639,
0.011548582,
-0.02640426,
0.02818904,
-0.008136502,
0.008477709,
-0.004813003,
-0.0055675977,
0.019265136,
-0.015367488,
-0.010360916,
0.0071456856,
0.014527592,
-0.028766468,
0.055380702,
0.014842553,
0.009127317,
0.01494754,
-0.016391113,
0.01661421,
0.01804466,
-0.006870094,
-0.0065124817,
-0.024212653,
-0.003392396,
-0.027244156,
0.022572229,
-0.020000044,
-0.014960663,
0.011922599,
0.0017109619,
0.01583993,
-0.014278247,
-0.0007353199,
0.029133923,
0.012952785,
0.034593254,
0.01677169,
-0.006099095,
-0.01138454,
0.029685106,
0.0002706699,
-0.004058408,
-0.0018372745,
-0.007191617,
0.0032103092,
-0.03493446,
0.011673255,
-0.013077457,
-0.012126012,
0.015367488,
-0.020262513,
0.010380601,
0.008563012,
0.000944884,
-0.02803156,
-0.005606968,
-0.0094094705,
0.024291394,
-0.0042716633,
-0.016482977,
-0.020577474,
-0.015958041
] |
Cytoplasmic Ca(2+) oscillations are a universal signaling mode that activates numerous cellular responses [1, 2]. Oscillations are considered the physiological mechanism of Ca(2+) signaling because they occur at low levels of stimulus intensity [3]. Ca(2+) oscillations are proposed to convey information in their amplitude and frequency, leading to activation of specific downstream targets [4-6]. Here, we report that the spatial Ca(2+) gradient within the oscillation is key. Ca(2+) oscillations in mast cells evoked over a range of agonist concentrations in the presence of external Ca(2+) were
|
[
-0.029982068,
-0.0040655895,
0.019732013,
-0.019705528,
-0.01108436,
0.022923568,
-0.019612828,
-0.0024416712,
-0.012898645,
-0.011839208,
0.013329042,
0.014368614,
-0.012653651,
0.003727894,
0.0041947085,
0.012481492,
0.028233996,
0.018937437,
-0.006128181,
0.032683633,
-0.018791763,
0.018434204,
0.0026171405,
-0.018844735,
0.009872628,
0.0076279463,
-0.0034862098,
-0.03120042,
-0.014924819,
-0.0063764863,
0.013262827,
0.008594682,
-0.018844735,
0.012461628,
0.013587279,
-0.019824715,
0.019189052,
-0.019904172,
0.009025079,
-0.002150326,
0.009952086,
0.0011388948,
-0.005416372,
-0.014567259,
-0.015202921,
-0.004313895,
0.017997187,
-0.0025674794,
-0.0038967417,
0.028366426,
0.0161829,
0.02472461,
-0.011905423,
-0.00059634715,
0.018646091,
-0.018354746,
0.004045725,
0.016063714,
0.019228783,
-0.033822525,
-0.013547551,
0.010640721,
-0.01524265,
0.007680918,
-0.0004945419,
0.010978416,
0.03334578,
0.03437873,
-0.0024267728,
-0.0003606638,
0.026181336,
0.011693536,
-0.02472461,
-0.00016005362,
0.0055852192,
-0.01028316,
-0.031491764,
-0.004472811,
-0.0044363923,
0.017202608,
0.011759751,
0.0058368356,
-0.007800105,
0.05975225,
-0.0053700213,
0.012077582,
-0.0098461425,
0.02297654,
-0.038245674,
-0.0031716896,
0.019930659,
0.007071742,
0.010382483,
0.007634568,
-0.0046648337,
0.00062035,
0.015573724,
0.027863193,
-0.030193955,
-0.018169345,
0.016076956,
0.00057772425,
-0.012660272,
-0.02310897,
-0.056891765,
-0.016712619,
-0.0028323387,
-0.0078067263,
0.012647029,
-0.010018301,
-0.013090668,
0.020089574,
-0.00594609,
-0.037980817,
0.015057248,
0.022314392,
0.013997812,
0.004628415,
-0.008786705,
-0.013070804,
0.014116998,
0.02194359,
0.013103912,
-0.010759907,
0.015878312,
0.022195205,
-0.002637005,
-0.010779772,
-0.009011836,
-0.00086741406,
-0.019877687,
0.014805632,
-0.013355528,
0.028763715,
-0.017454224,
0.016964234,
-0.0022761342,
-0.0023986315,
0.0070982277,
-0.02109604,
0.006406283,
0.029081546,
-0.027916165,
0.010382483,
0.012223254,
0.015957769,
0.022685194,
0.01989093,
0.0005570321,
0.010170595,
0.0066711423,
-0.016686132,
0.01273973,
-0.0053501567,
0.017335039,
0.020023359,
0.009071429,
0.027810222,
0.006710871,
-0.049555168,
0.009462097,
0.010091137,
0.02400949,
0.015229407,
0.013090668,
0.006386419,
0.019427426,
0.006052034,
-0.008998593,
-0.0020377608,
-0.025757562,
0.010561262,
-0.0057143383,
0.027412932,
-0.02743942,
0.0068995836,
0.0067870184,
0.010289782,
-0.009124401,
-0.017268823,
-0.037557043,
-0.0012133864,
0.0049197604,
-0.0064691873,
-0.0014923164,
-0.01345485,
0.029584778,
-0.015507509,
0.008376174,
-0.028286967,
-0.009753441,
-0.0053137387,
-0.0066181705,
0.010521534,
-0.6293056,
-0.009958708,
0.0072571435,
-0.023956519,
0.013295935,
0.03888134,
-0.00303926,
-0.002329106,
0.0009493549,
0.013527686,
-0.04076184,
0.0072306576,
0.0014054094,
-0.019692285,
-0.025439732,
-0.024525966,
-0.013587279,
-0.0019632692,
0.015428051,
-0.012527843,
-0.009435611,
-0.0037974196,
-0.020817937,
0.035385195,
0.0031187176,
0.028896144,
0.006038791,
-0.018884465,
-0.020897394,
0.052336186,
-0.015216164,
0.009912358,
-0.0029266947,
0.007939156,
0.0449731,
0.001479901,
-0.012190147,
0.03138582,
-0.005426304,
0.038642965,
-0.010038165,
-0.019149324,
0.034352243,
-0.011574349,
-0.029796666,
-0.0005673782,
0.0030475368,
-0.01537508,
-0.0070982277,
-0.030538272,
0.023771118,
-0.01501752,
-0.034802504,
0.014779146,
0.026300523,
-0.008753599,
0.008468875,
-0.0032461812,
-0.0027578468,
0.0249365,
0.0045290934,
0.029372891,
-0.01569291,
-0.029161004,
0.0035424924,
0.019639313,
-0.022301149,
-0.016792076,
0.015388322,
0.022234933,
0.011998124,
0.010488426,
0.005757378,
-0.00030872656,
0.00076064264,
0.028843172,
0.004747602,
0.00012166972,
0.0058136606,
0.021029824,
-0.010680449,
0.00786632,
-0.043357458,
-0.005131648,
0.018301774,
0.040735353,
-0.008846299,
0.028154539,
0.017864756,
-0.014964548,
0.008713869,
-0.0029978757,
0.0061612884,
-0.043119088,
-0.01591804,
0.020897394,
0.01050167,
0.0031584466,
0.00056903355,
-0.021082796,
-0.004287409,
0.012700001,
-0.0040887645,
-0.002610519,
0.00075650425,
-0.004085454,
-0.027783735,
0.00223475,
0.051832955,
-0.021453599,
0.026896456,
0.004519161,
-0.006240746,
-0.014461315,
-0.008866163,
-0.024804069,
0.018752035,
0.030856103,
-0.004787331,
-0.011825966,
0.0001637782,
-0.019321483,
0.009031701,
-0.013693224,
0.010084516,
0.02735996,
-0.0010528155,
-0.009223724,
-0.0071180924,
0.0014285846,
-0.031677168,
-0.028763715,
0.009025079,
-0.0058798753,
0.010250053,
0.023572473,
0.014580502,
0.004446325,
0.013554173,
-0.034564134,
-0.034590617,
-0.015798854,
-0.0064724977,
-0.026499169,
-0.0140772695,
-0.00058393186,
-0.045079045,
0.015745882,
0.012620543,
-0.003496142,
0.013295935,
-0.0049727326,
0.0029051749,
0.0033206728,
0.021996561,
-0.00047012517,
-0.01940094,
-0.0079788845,
0.0043867314,
-0.01367998,
0.01019046,
0.0070982277,
-0.03880188,
0.0065056053,
-0.019692285,
-0.024128677,
0.008329824,
-0.028949115,
0.006194396,
-0.02995558,
0.014381858,
-0.002082456,
0.010349375,
0.03263066,
-0.0030409154,
0.008442389,
-0.022791138,
0.006406283,
-0.014090512,
-0.013355528,
-0.009217102,
-0.025174871,
-0.017679354,
-0.009097915,
0.030246926,
0.013666737,
0.03088259,
0.0056381915,
0.0002447879,
0.025519188,
-0.029372891,
0.016129928,
-0.03795433,
0.0033819214,
0.0016015708,
-0.03313389,
0.001253943,
0.0011653807,
0.012256362,
0.024645153,
0.008197394,
0.0004850235,
0.026499169,
-0.009170751,
-0.007171064,
-0.012660272,
-0.00015570827,
-0.02525433,
0.02794265,
0.016143171,
0.0058169714,
0.008468875,
0.0057739317,
-0.026459439,
0.0014078924,
0.0062738536,
-0.0067936396,
0.006048723,
0.021983318,
-0.017546926,
0.008647654,
-0.012964861,
0.038166218,
0.01108436,
-0.004956179,
0.015096977,
0.003186588,
0.031041505,
-0.0011397224,
0.017374767,
-0.01765287,
0.013395256,
-0.015255893,
0.018632848,
-0.0013789234,
0.012680137,
-0.017732326,
-0.0021735013,
0.021797916,
-0.0067803967,
0.008786705,
0.026181336,
0.0270024,
-0.0024035978,
-0.017229095,
-0.0045787543,
0.021453599,
0.0016702686,
-0.009938844,
0.0023324168,
-0.006419526,
0.0049992185,
-0.04876059,
0.0055057616,
0.00030665734,
-0.0052541452,
0.01685829,
-0.004161601,
0.027598334,
0.027306989,
0.027730763,
0.0016735793,
0.027995624,
-0.016116686,
-0.01144192,
0.021294683,
-0.00027189456,
-0.004482743,
-0.023281127,
-0.020645779,
-0.01524265,
-0.011024767,
0.0179707,
-0.015971012,
0.016950993,
-0.007541867,
0.012779458,
0.0030078078,
0.023612203,
0.015891556,
-0.020433892,
-0.045529306,
-0.008482117,
0.012097446,
-0.014328886,
-0.0133687705,
-0.020844422,
-0.0069525554,
-0.009952086,
0.010362619,
-0.0013044318,
0.007945778,
-0.039146196,
-0.017242337,
-0.012183526,
-0.0065420233,
0.027412932,
0.00063317915,
0.013474714,
0.00040866956,
-0.0019632692,
0.00005317877,
-0.01202461,
0.0072703864,
0.021281442,
0.010104381,
0.008369552,
-0.0047211163,
-0.00023154492,
-0.027174558,
0.011819344,
-0.0030011863,
-0.004611862,
-0.031120962,
0.009415747,
-0.0006191085,
0.044867158,
-0.00083347893,
0.058110118,
-0.0007329152,
-0.011998124,
-0.008660898,
0.00084920495,
-0.031995,
0.0134151215,
0.008601304,
0.009376017,
0.0064923624,
-0.019612828,
-0.018447448,
-0.018116374,
-0.0064890515,
0.02132117,
-0.02034119,
-0.020460377,
-0.013064182,
0.0031816217,
0.007224036,
-0.0026270726,
0.030273411,
-0.0005131648,
-0.015785612,
0.012997968,
-0.005552112,
0.008058343,
0.007184307,
0.035332225,
0.04068238,
0.027068615,
-0.012885403,
-0.009647498,
0.017401252,
0.004621794,
-0.03361064,
0.007800105,
0.015388322,
-0.0002071282,
-0.0068135043,
-0.03549114,
-0.03003504,
-0.011978259,
0.026340252,
-0.019096352,
0.004764156,
0.021427114,
0.008839677,
0.0039066738,
-0.0017679355,
-0.015971012,
-0.022062775,
0.009064808,
0.02735996,
0.008051721,
0.0022132301,
0.041609388,
-0.027148074,
-0.0024333943,
-0.036471117,
0.015931284,
-0.011375705,
-0.012991346,
-0.018235559,
0.018473933,
-0.0039364705,
-0.011163818,
0.0041020075,
-0.003999375,
-0.010806258,
0.0027876436,
-0.0014476214,
-0.028816687,
-0.021559544,
-0.027518876,
0.014805632,
-0.008607926,
-0.042483423,
-0.035332225,
-0.0035391818,
0.044046093,
0.02369166,
0.014315642,
0.00286048,
-0.011733265,
0.034431703,
-0.020685507,
-0.029584778,
-0.042986657,
-0.05167404,
0.0057242704,
0.018924193,
0.029876124,
-0.007906049,
0.013017832,
0.00029631128,
0.039543487,
-0.0036583685,
0.02310897,
0.001354093,
-0.0058434573,
0.023519501,
0.011885559,
-0.003585532,
0.016129928,
-0.016129928,
0.0033206728,
-0.03919917,
-0.017215852,
-0.009640877,
-0.0054925187,
-0.009852764,
0.0145275295,
0.021864131,
-0.009839521,
-0.0007685057,
-0.008991972,
-0.018209074,
0.01644776,
-0.015096977,
0.0020245179,
0.018553391,
0.022817625,
0.0159975,
-0.012461628,
-0.02096361,
0.013428364,
-0.004777399,
0.022009803,
-0.014368614,
-0.018301774,
0.01148827,
0.0059791976,
0.008978728,
-0.021758188,
0.007303494,
-0.013289313,
0.028763715,
-0.020433892,
-0.028949115,
-0.011428677,
0.017202608,
0.003112096,
0.015626695,
-0.009799792,
-0.011971639,
-0.0066347243,
0.01019046,
-0.0072703864,
-0.031942025,
0.035173308,
-0.04237748,
-0.00024023562,
-0.014103755,
-0.0005868288,
0.009303181,
-0.0050852974,
0.009422367,
-0.019030137,
-0.021294683,
0.005168066,
-0.06012305,
-0.013044318,
-0.016831806,
0.033504695,
0.014328886,
0.026565382,
0.012282847,
0.010210324,
0.014646716,
-0.014514287,
-0.01019046,
-0.009627634,
-0.0036716114,
-0.02659187,
0.021612516,
0.010647342,
0.007482274,
0.024472995,
-0.015361836,
0.023360586,
0.02181116,
0.003110441,
-0.017401252,
-0.0025873438,
-0.02534703,
-0.018632848,
0.0018871222,
-0.019228783,
-0.012547707,
-0.0069525554,
-0.0130376965,
0.038060274,
0.012216633,
-0.011938531,
-0.025982693,
0.0077471333,
-0.03151825,
0.019904172,
-0.036497604,
0.02248655,
-0.023718147,
-0.029346405,
-0.012726487,
0.004492675,
0.016063714,
0.012534464,
-0.00241353,
0.0033769554,
-0.007892806,
-0.016580189,
-0.019083109,
-0.01998363,
0.008276852,
-0.025241086,
-0.0034266165,
-0.031173933,
-0.013289313,
-0.022910325,
-0.030379357,
-0.00952169,
0.018791763,
-0.02190386,
0.019599585,
-0.023029512,
-0.010740043,
0.040602922,
0.01246825,
0.016288843,
-0.02704213,
0.031306364,
-0.010680449,
0.013468093,
-0.011527999,
-0.005280631,
-0.00800537,
0.010210324,
0.038854852,
0.0033008084,
-0.02194359,
-0.020513348,
0.004330449,
0.011912045,
-0.0095150685,
-0.024618667,
0.015083734,
0.016143171,
0.004913139,
-0.017176121,
0.011097603,
-0.0068730977,
0.0038470805,
-0.012799324,
-0.012938375,
0.005906361,
0.0026833552,
-0.04264234,
0.03639166,
-0.0064791194,
0.020169033,
0.0059957514,
-0.008886028,
-0.014805632,
0.00088893384,
-0.011567728,
0.017017206,
-0.0022016426,
0.0029117963,
0.006012305,
-0.006055345,
0.007839833,
0.013918353,
0.008449011,
-0.02583702,
-0.0007325014,
0.041503444,
0.010309646,
-0.010528156,
0.045555793,
0.011806102,
-0.0004024619,
-0.028181024,
-0.009594526,
-0.018169345,
-0.040576436,
0.012839052,
0.030644216,
0.01269338,
-0.0038901202,
-0.020010116,
-0.021639,
-0.005386575,
-0.031306364,
0.006866476,
0.0032379043,
-0.017176121,
-0.0053302925,
0.0066148597,
0.005581909,
0.03686841,
0.0050058397,
-0.011329355,
0.015308864,
0.017599897,
-0.017732326,
0.012229876,
0.027545363,
0.0024284283,
-0.029876124,
0.0011877283,
0.007469031,
-0.012752973,
0.015189678,
-0.009534933,
-0.033690095,
0.009356153,
-0.011408812,
0.034166843,
0.010759907,
0.012289469,
-0.005257456,
0.022764653,
0.00800537,
0.0008814847,
-0.006373176,
-0.004929693,
-0.014633474,
-0.00035859458,
0.023863818,
-0.003362057,
-0.0036053965,
0.014686446,
0.000011438868,
0.0058533894,
-0.0021850888,
-0.005154823,
-0.019957144,
0.0058004176,
-0.01712315,
-0.027386447,
-0.01085923,
-0.005833525,
-0.015706154,
0.03183608,
-0.0048866533,
0.008217258,
-0.012051096,
-0.036418147,
0.006710871,
0.015944527,
-0.004889964,
0.005244213,
0.017983943,
-0.02557216,
-0.033637125,
0.0061679096,
-0.043198545,
0.006558577,
0.0034067521,
-0.013825653,
0.0015750849,
0.016156415,
-0.028181024,
-0.01475266,
-0.005873254,
-0.0031534804,
-0.0022099193,
0.021400627,
-0.0035491139,
0.009025079,
-0.017361524,
0.00257079,
-0.0014236185,
0.0054561007,
0.008786705,
-0.024830556,
0.0010238466,
-0.0016818562,
-0.032577686,
0.008568197,
0.030008553,
-0.006068588,
0.0027561917,
0.013348906,
-0.011203546,
0.006280475,
0.01774557,
0.0012001435,
-0.019480398,
0.023493016,
0.024817312,
-0.034537647,
0.0015452881,
-0.00093528425,
-0.007667675,
-0.020976853,
0.0016967546,
-0.0018026982,
0.004479432,
0.0062573,
-0.0050621224,
-0.03106799,
0.015984256,
-0.0035590462,
0.0041682227,
0.0376365,
-0.030538272,
0.0080252355,
0.017891243,
-0.011693536,
-0.028869659,
-0.001343333,
-0.022950053,
0.009124401,
-0.006114938,
-0.0032064524,
0.0019566477,
0.013852139,
0.009985194,
-0.03281606,
0.0021354277,
-0.018407717,
0.019228783,
-0.038033787,
0.01944067,
0.02069875,
-0.030988533,
-0.0010420557,
-0.022446822,
-0.021996561,
-0.017639626,
-0.008482117,
0.0033736448,
-0.0014873502,
0.007190929,
0.0140772695,
-0.0028720675,
0.026671326,
-0.012249741,
-0.018407717,
-0.023042755,
0.015136706,
0.18052806,
-0.02516163,
-0.0072770077,
0.02297654,
-0.001582534,
0.0036980973,
0.005757378,
-0.0010395725,
-0.019149324,
-0.026697813,
0.019798229,
0.011885559,
0.0075815963,
-0.0069393124,
-0.0032279722,
0.0019682352,
-0.0038967417,
0.009753441,
-0.0070916065,
0.00008132007,
0.014898333,
-0.027651306,
-0.0143951,
0.011633943,
0.04089427,
-0.011236654,
-0.008276852,
-0.008607926,
0.020778209,
0.020619292,
-0.021069553,
0.028048595,
-0.0022579252,
0.0035921535,
0.0008252021,
0.008886028,
-0.000678288,
-0.01851366,
0.025267573,
-0.0021470152,
-0.0030938871,
0.003112096,
-0.028128052,
-0.005105162,
-0.0014525874,
0.012686758,
0.0052541452,
-0.03419333,
0.0037874873,
-0.0051846197,
-0.041768305,
0.020036602,
0.0016206076,
0.032577686,
-0.010561262,
-0.0039530243,
0.015004276,
0.039305113,
-0.010746664,
0.017003965,
-0.02346653,
-0.0053832643,
-0.0055123833,
0.018778522,
-0.02588999,
-0.007071742,
-0.024433266,
0.00084672193,
0.012812566,
-0.017798541,
-0.0071048494,
0.011402191,
-0.019586341,
-0.005131648,
-0.021360898,
0.0077934833,
0.0149513045,
0.019957144,
0.01028316,
0.007290251,
0.0005160617,
0.015533995,
-0.032577686,
-0.013057561,
0.014845361,
-0.016341817,
0.018553391,
0.019957144,
-0.014898333,
0.0125410855,
-0.0066181705,
-0.014368614,
-0.0046813875,
-0.009899114,
0.0077007827,
-0.022950053,
-0.0049197604,
-0.022009803,
-0.007488895,
-0.0000037536815,
-0.014818875,
0.07077039,
0.029293433,
0.015255893,
-0.003751069,
-0.015891556,
-0.012057717,
0.0056216377,
0.002807508,
-0.009905736,
0.011958395,
-0.004466189,
0.0074226805,
-0.009270074,
-0.020327948,
0.021970075,
0.0025807223,
-0.013196612,
0.06176518,
-0.014222941,
-0.022314392,
-0.033822525,
-0.010005058,
0.017507197,
0.008290094,
0.008329824,
-0.02369166,
0.0032792885,
-0.006700939,
-0.03580897,
0.016487489,
0.015785612,
0.0028356493,
0.011296247,
0.019811472,
-0.005403129,
-0.015745882,
-0.030193955,
-0.0015138362,
-0.01748071,
-0.0027876436,
-0.007177686,
0.0012175249,
0.040391035,
0.00187719,
-0.012488114,
0.015507509,
0.028022109,
-0.008568197,
-0.021771431,
-0.0020195518,
-0.021268198,
-0.0007027047,
-0.010230188,
0.046376854,
-0.01640803,
-0.022645466,
-0.027677791,
0.008819813,
0.0036583685,
-0.020010116,
-0.009746821,
0.0071512,
0.0025823778,
-0.00768754,
-0.009548176,
-0.16495433,
0.014712932,
0.023519501,
-0.016898021,
0.021956831,
0.013785924,
-0.0017729016,
0.016553704,
-0.0028240618,
-0.0028770335,
0.012627165,
0.007879563,
-0.027412932,
-0.017268823,
0.029161004,
-0.0049992185,
-0.0035557353,
0.026830243,
-0.004797263,
0.027598334,
0.018871222,
-0.029823152,
0.042165592,
-0.02668457,
0.006432769,
0.009223724,
-0.0011157196,
-0.017361524,
0.0035822215,
-0.032710116,
-0.026207823,
0.01748071,
0.007210793,
0.009965329,
0.03858999,
-0.012269605,
-0.014991034,
-0.003741137,
-0.00737633,
0.020711994,
0.017983943,
0.015441295,
-0.015428051,
0.0048303707,
-0.014924819,
0.020327948,
-0.008442389,
-0.013011211,
0.010183838,
-0.019573098,
0.0147394175,
-0.016355058,
0.006846612,
0.031862568,
-0.009528312,
0.028684257,
0.012507978,
0.017811785,
0.0055090724,
-0.017520439,
0.0053832643,
-0.0060056834,
0.026009178,
-0.0017646247,
-0.0050753653,
-0.01601074,
-0.013315799,
0.0065056053,
-0.021281442,
0.012421899,
-0.018089887,
-0.017493954,
0.014011054,
-0.026313767,
0.030432329,
0.008078207,
0.010395725,
-0.008468875,
0.0026138297,
0.007363087,
-0.0065916847,
0.018871222,
-0.033901986,
-0.029664235,
-0.008647654,
-0.010726799,
0.008813191,
0.029213976,
0.009793171,
0.00034245473,
0.02587675,
-0.009806414,
0.0030425705,
-0.012143796,
0.030856103,
-0.006575131,
-0.0053137387,
0.006217571,
0.0019632692,
0.009945465,
0.031571224,
0.008336445,
0.0064261477,
0.02171846,
0.013997812,
-0.0077338903,
-0.01332242,
-0.010408969,
0.023969762,
-0.02400949,
-0.026896456,
-0.016990721,
0.007952399,
0.012289469,
-0.016129928,
0.028445883,
-0.0043602455,
0.0022827557,
0.006598306,
-0.012527843,
0.06261273,
0.003446481,
-0.010051409,
0.016474245,
-0.021691972,
-0.038907822,
-0.14524882,
-0.009786549,
0.0069326907,
0.02833994,
-0.0023257954,
0.011388948,
0.00473767,
0.015123463,
-0.016275601,
0.035411682,
-0.032153912,
-0.010329511,
0.006446012,
-0.0016305398,
0.0106738275,
0.019573098,
0.03723921,
-0.013891867,
-0.029849637,
0.012772838,
-0.0052144164,
-0.004608551,
-0.0125146,
0.010448697,
-0.0024830555,
0.02024849,
-0.018089887,
0.021983318,
-0.0029664235,
0.015216164,
0.0013756127,
0.0071313353,
0.028869659,
0.0054428577,
-0.013825653,
0.0024780894,
0.0067208037,
-0.03244526,
0.033796042,
-0.0036848544,
0.0021784673,
0.016103443,
0.031120962,
0.007786862,
0.005373332,
0.0070518777,
0.001716619,
0.016871534,
0.01126314,
-0.021533057,
-0.011792858,
-0.019122837,
-0.02440678,
-0.0036815435,
0.02171846,
-0.002534372,
-0.0065420233,
0.014567259,
-0.00750876,
0.011494892,
0.006091763,
-0.003598775,
-0.021281442,
-0.004446325,
0.034537647,
-0.03003504,
-0.0072571435,
-0.03702732,
0.021599272,
-0.011097603,
-0.0052111056,
0.018778522,
-0.011104224,
0.015984256,
-0.021334413,
0.017467467,
0.0046880087,
0.010475183,
-0.016712619,
0.005605084,
-0.012309333,
-0.025042443,
0.008601304,
-0.019255267,
0.015030762,
-0.00029941511,
0.024976227,
0.0033901983,
-0.0026022422,
-0.023360586,
-0.032524716,
0.02641971,
0.004793952,
-0.02038092,
-0.0060023726,
0.007839833,
0.002633694,
0.006220882,
0.013838896,
0.018341502,
-0.01497779,
-0.02950532,
-0.031306364,
0.020526592,
0.015560481,
0.00037638983,
0.0034630348,
-0.03496142,
0.01842096,
-0.023347342,
-0.00030541583,
0.017136393,
0.0017977322,
0.009157509,
0.0050488794,
-0.00058558723,
-0.019943902,
-0.03607383,
0.026009178,
-0.021572785,
0.020274976,
0.040523466,
-0.013137019,
0.007853077,
0.024380295,
-0.00019150565,
-0.009230345,
0.014633474,
-0.002158603,
0.014580502,
-0.013209855,
-0.007594839,
0.0048866533,
-0.039119713,
-0.014514287,
0.0064923624,
-0.038298648,
-0.020764966,
-0.001832495,
0.02494974,
0.01891095,
0.028233996,
0.0026088636,
-0.02060605,
0.00594609,
-0.013918353,
-0.005280631,
-0.0018126304,
-0.03978186,
0.009733577,
0.013242963,
-0.013627009,
0.010104381,
0.019427426,
0.0056481236,
-0.013547551,
0.004519161,
0.0010230188,
0.01202461,
0.018844735,
0.0032875654,
-0.0029382822,
0.01913608,
0.03281606,
0.008343066,
-0.0025045753,
0.0017977322,
0.00081816677,
-0.049316794,
-0.005747446,
0.029849637,
-0.016911263,
-0.01367998,
0.009746821,
0.022499794,
-0.0041549797,
-0.010263296,
0.02423462,
0.0014343783,
-0.0115478635,
-0.011580971,
0.024896769,
0.02570459,
-0.0014592089,
-0.011527999,
0.00929656,
0.023281127,
0.017083421,
-0.01207096,
0.02056632,
0.00257079,
-0.004135115,
0.006061966,
0.0069790413,
0.00060876244,
0.0029432485,
0.02181116,
0.02833994,
-0.01622263,
0.0020443823,
0.00018809145,
0.04362232,
0.0054792757,
0.026658084,
0.011044631,
-0.036471117,
0.017017206,
0.026949428,
-0.041556418,
-0.028975602,
-0.017546926,
0.029452348,
0.019573098,
0.001595777,
0.014858604,
0.0008086484,
-0.0038603237,
0.014448072,
0.017586654,
-0.0037179617,
-0.008204015,
0.008422524,
-0.0055123833,
-0.003262735,
-0.017083421,
-0.016686132,
-0.0057375133,
-0.008833056,
0.041980192,
0.0002954836,
0.0049065175,
-0.012163661,
0.028763715,
-0.027095102,
0.0009030045,
-0.019824715,
-0.0048833424,
-0.02516163,
0.01113071,
0.0061844634,
-0.02024849,
0.06404296,
-0.0023804225,
0.009323046,
0.017917728,
0.0006633896,
0.02668457,
-0.0021983318,
0.032683633,
-0.02346653,
-0.040841296,
-0.0061977063,
-0.02109604,
0.015189678,
-0.03843108,
-0.006101695,
0.034272786,
-0.0060288585,
0.010005058,
0.0021701904,
-0.03371658,
0.015812097,
-0.018394476,
-0.0048403027,
0.0017695909,
-0.011408812,
-0.015560481,
0.028286967,
-0.0026932876,
-0.015653182,
-0.044681754,
0.005081987,
-0.012958239,
-0.055991247,
0.002231439,
-0.02463191,
-0.017440982,
-0.009713713,
-0.006919448,
-0.0027363272,
0.009945465,
-0.046006054,
0.011276383,
-0.015507509,
-0.02659187,
0.0007954054,
0.013878625,
-0.010958551,
0.010435455,
-0.029240461
] |
CONTEXT Chronic low back pain (LBP) with degenerative lumbar osteoarthritis (OA) is widespread in the adult population. Although glucosamine is increasingly used by patients with chronic LBP, little is known about its effect in this setting. OBJECTIVE To investigate the effect of glucosamine in patients with chronic LBP and degenerative lumbar OA. DESIGN, SETTING, AND PARTICIPANTS A double-blind, randomized, placebo-controlled trial conducted at Oslo University Hospital Outpatient Clinic, Oslo, Norway, with 250 patients older than 25 years of age with chronic LBP (>6 months) and degenerative
|
[
0.001620309,
0.016346304,
0.039859936,
-0.053874858,
-0.02455276,
0.014467877,
-0.0374353,
-0.00091423397,
-0.009492046,
-0.013681869,
0.007660248,
0.0109108575,
0.0040532704,
0.017318822,
-0.011277217,
0.011583627,
0.050677538,
0.009378808,
0.013635241,
-0.0062947255,
-0.01565355,
0.00926557,
-0.0025711788,
-0.011570305,
-0.0038534377,
0.008552833,
-0.0019267189,
-0.023673497,
0.00343712,
-0.0046760817,
0.015906671,
0.0013913342,
-0.012542823,
-0.018837549,
-0.0046627596,
-0.02405984,
-0.010264732,
-0.009318858,
0.0025511957,
-0.005045772,
0.022594402,
0.0017934972,
-0.0014929157,
-0.0077135367,
0.014134822,
-0.017891675,
-0.008552833,
-0.0064046336,
-0.004995814,
0.007573654,
-0.0008734348,
0.034024823,
-0.023220543,
0.0075403485,
0.03093408,
-0.022874167,
0.010564481,
0.011203946,
0.004892567,
-0.034078114,
-0.00939213,
0.014401266,
-0.020063188,
-0.0049858224,
-0.020689331,
0.01798493,
-0.0077668256,
0.020063188,
0.01344207,
-0.009751828,
0.023433698,
0.05027787,
-0.0020416225,
0.0011423761,
0.015520329,
0.0012439577,
-0.0011781794,
-0.028429512,
0.008066574,
0.0080865575,
0.023113966,
-0.0152938515,
0.0083530005,
0.026111454,
0.002436292,
-0.014228078,
0.017891675,
0.014387944,
-0.023127288,
-0.02792327,
-0.026257997,
0.008612784,
0.016852546,
0.007886725,
-0.024659337,
0.021715138,
0.0032972372,
0.024272995,
-0.006118207,
-0.009705201,
-0.029175553,
-0.008359662,
-0.016506169,
-0.012682706,
-0.027790047,
-0.022194736,
-0.006328031,
0.019077348,
0.034397844,
0.005965002,
-0.02246118,
0.061175406,
0.0008984139,
-0.017105667,
-0.015267207,
-0.017918319,
0.017891675,
-0.006148182,
0.02092913,
-0.025645178,
0.009591963,
-0.020422887,
0.011523677,
-0.020462854,
-0.0027959906,
0.011969971,
-0.036129728,
0.019490335,
-0.0020349615,
0.012096531,
-0.016492847,
0.042497724,
0.01866436,
0.009591963,
-0.006371328,
0.009598624,
-0.0067510097,
-0.016679358,
-0.046361152,
-0.047053907,
-0.010058239,
0.018278018,
-0.035197176,
-0.0026411202,
0.014601098,
0.013089033,
0.04444276,
0.010877552,
-0.007433771,
-0.022474501,
-0.0050424417,
-0.012755978,
0.010671059,
0.010078222,
-0.0002787248,
-0.015933316,
0.0070008007,
0.032426164,
-0.020715974,
-0.018104829,
-0.01662607,
-0.01528053,
0.013615258,
0.00095919624,
-0.022554435,
0.01166356,
-0.00411322,
-0.005788483,
-0.0022014887,
0.0059583406,
-0.0013838405,
0.03008146,
0.005488734,
0.008726021,
0.00065195374,
0.0048292866,
-0.014934153,
-0.00803993,
-0.015173952,
-0.01645288,
-0.024126451,
-0.014747643,
0.011383794,
-0.0031806682,
-0.005715211,
-0.011603611,
0.021981582,
-0.014254723,
0.00988505,
-0.008326356,
0.013368798,
0.028003203,
-0.004253103,
-0.005701889,
-0.6313643,
-0.030854147,
0.035889927,
-0.0105444975,
0.01049787,
0.021701816,
0.017825063,
0.005445437,
-0.019743457,
0.039193824,
-0.010184799,
0.041565172,
0.020902485,
-0.001108238,
0.006284734,
-0.021009063,
0.0059716627,
-0.028562734,
0.028802533,
-0.015613584,
-0.008912532,
-0.010504532,
0.019730134,
0.006118207,
0.024952425,
0.028935755,
0.021835037,
-0.029788373,
0.011750154,
0.04617464,
-0.018451206,
0.03338536,
-0.013468714,
0.01619976,
0.051450223,
-0.02608481,
-0.025405379,
0.0031290448,
0.011949987,
0.024139773,
-0.035436973,
-0.018651038,
0.0047526844,
-0.008259745,
-0.043430276,
0.0011090707,
0.030614348,
0.011317184,
-0.0072405995,
0.0066377716,
0.02062272,
0.014334655,
0.0034604338,
-0.020302989,
-0.000886757,
-0.008432934,
0.014747643,
-0.02479256,
0.015173952,
0.0018268026,
-0.004769337,
0.030001529,
-0.009558657,
-0.017305499,
-0.02792327,
0.0100649,
-0.015853383,
0.00853285,
0.0058550937,
0.014587777,
0.035303753,
0.026377898,
-0.0015986605,
-0.0020632711,
0.04438947,
0.010990791,
0.011383794,
0.021315472,
-0.03847443,
-0.004283078,
-0.007966658,
0.004143195,
0.0014712672,
0.0009991628,
0.046920683,
0.01975678,
-0.0402596,
0.0071007167,
0.016985767,
-0.02731045,
0.020076511,
0.038767517,
-0.037275434,
-0.011457067,
-0.010804281,
0.028402867,
-0.0018667692,
0.019836713,
0.022394568,
-0.02136876,
-0.009538674,
0.017052379,
0.011916681,
0.00037843292,
-0.0023230535,
0.013248898,
-0.032133076,
-0.0015420412,
0.048412766,
-0.031014012,
0.01338212,
-0.018677684,
0.005432115,
-0.0099450005,
0.032053143,
-0.016106505,
0.0046927347,
-0.043403633,
0.0025611874,
-0.04905223,
0.010797619,
-0.003247279,
0.009125687,
-0.021462016,
0.0015845057,
0.011670222,
-0.0171856,
-0.022847522,
-0.016919157,
-0.017545298,
0.002437957,
0.0005607801,
0.022487823,
0.00023771748,
0.022674333,
-0.006421286,
0.015333818,
-0.0014213091,
0.033491936,
-0.046361152,
-0.027630182,
-0.012236414,
-0.011736833,
-0.013188949,
-0.0039866595,
0.009745168,
-0.015813416,
0.00356035,
-0.006587813,
0.017758453,
0.0032939066,
-0.031040657,
-0.025605211,
0.028136425,
-0.014281367,
-0.0034404504,
-0.009991628,
-0.010764314,
-0.01657278,
-0.010144833,
0.0034204673,
-0.005358843,
-0.011437084,
-0.013355476,
-0.013262221,
-0.034904085,
0.018517816,
0.013721836,
0.0058817384,
-0.030667637,
-0.0073871436,
-0.01847785,
0.0034970697,
0.0036469442,
-0.004529538,
0.008559494,
0.010298038,
-0.004046609,
0.025871655,
-0.006131529,
0.00073355203,
0.022514468,
0.0032306262,
0.022541113,
0.008446256,
0.009165653,
0.008805955,
0.033172205,
-0.019103993,
0.005395479,
-0.013208932,
0.042870745,
-0.030800859,
0.001816811,
-0.008646089,
-0.030800859,
-0.031200523,
0.0046361154,
0.020969097,
0.009132348,
0.019410402,
-0.04510887,
0.03165348,
-0.017318822,
0.026657663,
-0.026524441,
-0.009831762,
-0.022168092,
0.030188039,
0.0054354453,
-0.003105731,
0.00067818176,
0.00021523632,
-0.02264769,
0.015533651,
0.0254187,
-0.0034904086,
-0.0033471952,
0.0013222254,
-0.009112365,
0.011323845,
0.017904997,
0.028802533,
-0.0011232255,
-0.016799256,
0.03285247,
0.003590325,
0.018331306,
0.016985767,
-0.0025928274,
-0.003567011,
0.004652768,
-0.012596112,
0.0171856,
0.0072139553,
0.009032432,
-0.009825101,
-0.019103993,
0.03738201,
0.0053488514,
-0.0016894178,
0.013448731,
-0.0006964997,
0.004762676,
0.0035270446,
0.018637717,
0.017811742,
-0.0029741745,
-0.003983329,
-0.00083013775,
-0.02300739,
0.0046061403,
-0.0051656715,
-0.001547037,
0.0021631874,
0.00050582614,
-0.00067943067,
0.028189713,
0.05616627,
0.027083972,
0.02264769,
0.017971609,
0.0026277981,
0.0077668256,
0.021808393,
-0.015786773,
-0.011437084,
0.0005620291,
-0.015880028,
0.0061015543,
-0.01405489,
-0.028616022,
0.01117064,
-0.040685907,
0.015267207,
0.008479562,
0.019050704,
-0.0026094802,
0.03498402,
0.00079308543,
-0.0040965676,
-0.04758679,
0.018944126,
-0.0044429437,
-0.0076136203,
0.0072938884,
-0.014068212,
0.01117064,
-0.025791721,
0.012329669,
0.0026894133,
0.0024213046,
0.011090707,
-0.0036103083,
0.015120664,
0.0054154624,
0.038900737,
0.00079558336,
-0.000474186,
-0.019836713,
-0.00840629,
-0.00478599,
0.0030824172,
-0.01737211,
0.020915808,
0.0067476793,
-0.031387035,
-0.0040899063,
0.005575328,
-0.02302071,
0.020223055,
-0.012989116,
-0.0012431251,
-0.0022331288,
0.009831762,
0.02363353,
0.0029658482,
0.018464528,
0.027630182,
-0.014494522,
0.00047376967,
-0.037088923,
-0.0017485349,
-0.016905835,
0.020236377,
-0.0046128016,
0.0011240582,
0.020449532,
0.011363812,
0.024965748,
0.036795836,
-0.027203873,
0.0227143,
0.024139773,
-0.013062388,
0.02712394,
-0.020476175,
0.0021648528,
0.007893386,
0.031999853,
0.0040366175,
-0.010644414,
0.015387107,
0.010631092,
0.01565355,
0.015999926,
0.020409565,
0.03668926,
0.019157281,
0.00036157202,
-0.0042264587,
0.013628581,
0.010351326,
0.010131511,
-0.000094191906,
0.001206489,
-0.0003638618,
0.021435373,
-0.03234623,
-0.0065711606,
0.015200596,
-0.0013646898,
0.014840898,
0.013961635,
0.013988279,
-0.001970016,
0.024939103,
0.00088176114,
0.01135715,
-0.011623594,
-0.016226403,
0.011057401,
0.004399647,
-0.0038634294,
0.02086252,
-0.009738507,
0.009771812,
-0.015240563,
0.031387035,
-0.019090671,
-0.014867542,
0.005788483,
0.016732646,
-0.0126027735,
-0.012729334,
-0.01939708,
0.009258908,
-0.01970349,
0.003430459,
-0.025432024,
-0.039247114,
0.0058517633,
-0.006497889,
0.0028026516,
-0.018930804,
-0.001252284,
-0.0025944926,
0.0020133131,
0.0114171,
0.0038334546,
0.040312886,
-0.02344702,
0.011969971,
0.014014923,
-0.013541986,
-0.0074537545,
-0.013302187,
-0.02479256,
0.014281367,
0.015413751,
0.014880864,
-0.016186437,
-0.013148982,
-0.014521166,
0.04604142,
0.003553689,
-0.0042431112,
0.0071473443,
-0.019596912,
-0.03271925,
0.02596491,
0.022367924,
-0.0055686673,
-0.009099042,
-0.004922542,
-0.011143995,
-0.0041298727,
-0.026870817,
-0.03466429,
0.002504568,
-0.007906708,
0.011343828,
0.019290503,
-0.0287226,
0.0043130526,
-0.00030516097,
-0.007094056,
-0.02184836,
0.0019600242,
0.010384632,
-0.009905034,
0.015107341,
0.04153853,
0.008825938,
-0.027257161,
-0.031280458,
0.030214682,
0.0013422087,
-0.002406317,
-0.013388781,
0.00300748,
-0.010471226,
-0.035250463,
-0.027736759,
-0.004872584,
0.029921595,
0.0009641921,
0.009338842,
-0.034024823,
0.021901648,
-0.0256585,
0.021781748,
-0.0005253931,
-0.021781748,
0.00092838873,
0.016346304,
0.009658573,
-0.012496196,
0.022261348,
-0.024725948,
-0.017012412,
-0.009238925,
-0.021928292,
0.0127026895,
-0.01823805,
0.0056319474,
-0.026444508,
-0.00791337,
-0.0048326175,
-0.0013047401,
0.016839223,
-0.0011282213,
0.03357187,
-0.004462927,
0.046068065,
-0.031680122,
-0.0051590106,
-0.0012289702,
0.018038219,
-0.0005041609,
-0.007560332,
-0.005991646,
-0.032985695,
0.036023147,
0.01657278,
-0.000025928795,
0.0025029029,
-0.024739271,
-0.02443286,
0.027710114,
-0.034717575,
-0.025831688,
-0.012902522,
-0.017132312,
-0.01565355,
-0.017811742,
-0.0056119645,
-0.0014537818,
-0.037781674,
-0.0031839986,
0.032506097,
0.024099806,
0.004979161,
-0.038874093,
0.036715902,
-0.026710952,
0.004056601,
0.012016598,
-0.01633298,
-0.0056985584,
-0.020103155,
-0.004136534,
0.020103155,
-0.009059076,
-0.002043288,
-0.002178175,
-0.016213082,
-0.021741781,
-0.01577345,
-0.0029308775,
-0.032426164,
0.01000495,
-0.01885087,
-0.029015686,
0.0032006514,
-0.013761802,
-0.024805881,
-0.014427911,
-0.0068542566,
0.014907509,
-0.0033605176,
0.0151606295,
-0.011443744,
-0.020942451,
0.027603537,
-0.0078201145,
0.02056943,
-0.023300476,
0.029015686,
-0.0012123175,
-0.011576966,
-0.016439559,
0.004406308,
0.0002943367,
-0.013895024,
0.019490335,
0.013408764,
-0.027337093,
-0.013921668,
0.00064029684,
0.0061115455,
-0.010437921,
-0.0034404504,
0.028855821,
0.025911622,
-0.026404541,
0.011790121,
-0.000662778,
-0.0284828,
0.03596986,
-0.00650788,
-0.00040403646,
0.025405379,
-0.0008900875,
-0.0058684163,
0.019064026,
-0.006900884,
0.013388781,
0.0059583406,
-0.02203487,
-0.012622757,
-0.008273068,
0.014121501,
0.022194736,
-0.012875877,
0.026098132,
-0.0022397898,
-0.010984129,
-0.01743872,
0.009338842,
-0.0029908272,
0.00046419437,
-0.017398754,
0.038181342,
-0.0009675226,
0.0018584428,
0.036369525,
0.009365486,
-0.004979161,
-0.0019133968,
0.0054221232,
-0.014920831,
-0.020156443,
-0.0056186253,
0.027949914,
0.021528628,
-0.04750686,
0.03362516,
-0.0075137042,
-0.0134354085,
-0.012656062,
-0.01767852,
-0.0037435298,
-0.020729298,
-0.010990791,
-0.012915844,
0.01473432,
0.01866436,
0.0010008281,
-0.02387333,
0.0067110434,
-0.019490335,
-0.035490263,
0.0256585,
0.030854147,
0.019370437,
-0.018464528,
0.007966658,
-0.029815018,
-0.04209806,
-0.0038567684,
-0.0062580896,
-0.019223891,
-0.03450442,
0.006741018,
-0.011463728,
-0.007840097,
-0.01903738,
0.01019146,
-0.021688493,
0.018624395,
-0.007173989,
-0.017145634,
0.0024079822,
-0.007906708,
-0.013022422,
0.021795072,
-0.0003519967,
0.026484475,
0.011303862,
0.018371273,
0.013488698,
0.0025578567,
-0.013342153,
-0.02399323,
0.0127693005,
-0.010031594,
-0.003670258,
-0.010271394,
-0.008213118,
-0.010564481,
0.009938339,
0.0033105593,
-0.009365486,
-0.008386306,
-0.0074537545,
-0.020556109,
0.0022864174,
-0.016213082,
-0.0050923997,
-0.0046927347,
-0.010158155,
-0.027790047,
-0.011823426,
-0.009525352,
0.026644342,
-0.010138172,
-0.021795072,
-0.041645106,
-0.02147534,
-0.020356277,
0.0024779236,
0.015573617,
-0.0054021403,
0.015706839,
0.014681032,
0.0053754956,
0.031200523,
0.0027943254,
-0.0035270446,
-0.002068267,
-0.030587703,
-0.008339679,
-0.03706228,
0.05568667,
0.016546136,
-0.018011574,
-0.013422087,
0.0029142248,
0.013974957,
-0.016346304,
-0.020556109,
0.019916644,
-0.01871765,
-0.018824227,
0.003487078,
-0.00013977871,
-0.005641939,
0.006377989,
-0.035756707,
0.0020216394,
-0.0015112337,
0.015813416,
0.012656062,
-0.022794234,
0.002406317,
-0.027150583,
0.027257161,
-0.0027943254,
-0.023153933,
-0.00558532,
0.0046927347,
-0.008999126,
0.0100449165,
0.0010857569,
0.00019119396,
0.013488698,
-0.007873403,
-0.013575291,
-0.0036402831,
0.004892567,
-0.0042197974,
0.0010233092,
0.007094056,
-0.004762676,
0.0012306354,
-0.011776798,
-0.024406217,
-0.011883376,
-0.022168092,
0.00957198,
-0.0042064753,
0.026924107,
0.008746005,
-0.005905052,
-0.025725111,
-0.0100649,
-0.021621883,
0.008359662,
-0.009638591,
-0.0027959906,
-0.022967422,
-0.009099042,
0.017545298,
-0.01344207,
-0.016319659,
0.01546704,
-0.011989953,
-0.013535325,
0.022780912,
0.18160783,
0.003000819,
-0.015933316,
0.010757653,
-0.0021049029,
0.029175553,
0.029575218,
0.0060116295,
-0.029335419,
0.018118152,
0.041058928,
-0.01190336,
0.0012739325,
-0.003352191,
-0.010124849,
-0.020169767,
-0.004939195,
-0.0013497024,
-0.00046627596,
-0.029735085,
0.00546209,
0.02866931,
0.00834634,
0.002977505,
0.023167254,
0.0018717649,
-0.0018784261,
-0.0042064753,
0.017318822,
0.030481126,
0.012955811,
0.013455392,
-0.002982501,
0.007586976,
0.0051423577,
0.007966658,
0.015800094,
-0.029441997,
-0.0057618385,
0.034451135,
-0.007193972,
-0.027004039,
-0.024526116,
0.004659429,
-0.0013638572,
0.009312198,
0.0013630246,
0.004283078,
-0.014094857,
0.0320265,
-0.03554355,
-0.021675171,
0.015373785,
0.029575218,
-0.010870891,
-0.013708513,
0.022181414,
-0.010757653,
-0.0028243002,
0.0075669927,
-0.019490335,
0.012682706,
0.0017485349,
0.018331306,
-0.018917482,
-0.008885887,
0.0029009026,
-0.02099574,
-0.013408764,
-0.023060678,
0.007247261,
-0.017198922,
-0.010238088,
0.008659411,
0.00025166414,
-0.013615258,
0.038207985,
0.0369557,
0.011363812,
-0.009805118,
-0.0043363664,
0.007347177,
-0.028989043,
0.01687919,
-0.02768347,
-0.023580242,
-0.0064545916,
0.01233633,
-0.0010241419,
0.00028517772,
0.0128026055,
0.0059983074,
0.003596986,
-0.008666072,
0.018504495,
-0.009578641,
-0.011283878,
-0.013581953,
-0.008372984,
0.01356197,
-0.01374848,
0.07199301,
-0.023113966,
0.014281367,
-0.015173952,
-0.00048958976,
-0.011443744,
-0.011310522,
-0.00460281,
0.02308732,
0.027363738,
-0.031280458,
-0.0036602663,
-0.023620209,
-0.01749201,
0.006880901,
0.02228799,
-0.020636043,
0.009185636,
-0.006457922,
-0.007507043,
-0.014427911,
0.0016261374,
0.021675171,
-0.0025878316,
0.018917482,
0.0062680813,
-0.02203487,
0.011616932,
-0.048386123,
-0.011969971,
-0.021168929,
0.0066744075,
0.017625231,
-0.010764314,
0.01669268,
-0.011703527,
0.018357951,
-0.022634368,
0.029122265,
-0.015120664,
-0.009352163,
0.027710114,
-0.0031873293,
0.023207221,
0.0055520143,
-0.012789284,
-0.008879227,
-0.022541113,
-0.0038068101,
-0.015706839,
0.0005424621,
0.0032056472,
0.012482874,
0.025178902,
-0.010604448,
-0.0150940195,
-0.024019873,
-0.008366323,
0.0058018053,
-0.026431186,
0.007946675,
0.03149361,
-0.006358006,
0.016293015,
-0.0064612525,
-0.16721988,
-0.007946675,
-0.00041527703,
-0.058404393,
0.012542823,
0.0126693845,
0.01638627,
-0.0065811523,
-0.006667746,
0.020636043,
0.01651949,
0.021435373,
-0.041058928,
-0.0044529354,
-0.0057418556,
-0.02928213,
-0.0021265515,
0.024352927,
0.016639391,
0.0058417716,
-0.0042730863,
-0.022887489,
0.019890001,
-0.026830852,
-0.0014271375,
0.028695956,
0.016253049,
0.030028172,
0.0030707603,
-0.0075270263,
-0.014867542,
-0.002737706,
0.026444508,
-0.0068542566,
-0.019623557,
0.0017618571,
0.0020083173,
0.024233028,
-0.00595168,
0.020302989,
-0.004396316,
0.03037455,
-0.010597787,
-0.0002720637,
0.0081198625,
0.020782586,
0.034237977,
-0.022874167,
0.0008975812,
0.015493684,
-0.01356197,
-0.023540275,
0.032932404,
0.012209769,
-0.003836785,
0.024912458,
0.029175553,
0.009898373,
-0.011270557,
-0.010484548,
-0.009558657,
-0.010824263,
-0.0032056472,
0.011810104,
0.015933316,
-0.0042431112,
-0.0015853383,
0.0074604154,
-0.0042364504,
0.0061281985,
-0.02497907,
0.014308011,
-0.0003819716,
0.002737706,
0.011876715,
0.028562734,
0.020369599,
0.022367924,
0.022474501,
0.0015412086,
-0.018091507,
-0.008472901,
-0.034584355,
-0.011457067,
-0.00074604154,
0.019383758,
0.018624395,
0.04289739,
0.013235576,
-0.02688414,
0.017118989,
-0.02191497,
-0.014707676,
0.013555309,
0.0039067264,
0.025858333,
-0.003112392,
-0.0021465346,
-0.018278018,
-0.0025445346,
0.0041032284,
-0.018064864,
-0.017811742,
0.0063979723,
0.01805154,
-0.010551159,
-0.028349578,
0.0070740725,
0.015480362,
-0.009791795,
-0.008366323,
-0.0014895851,
0.022234702,
0.018944126,
0.006181487,
-0.0024229698,
-0.0006161504,
-0.010984129,
0.0034404504,
-0.0077734864,
0.046867397,
0.002246451,
-0.02154195,
-0.0070074615,
-0.016959123,
0.0071473443,
-0.11648906,
-0.0028825847,
0.006677738,
-0.011430422,
-0.0022198067,
0.038394496,
-0.015640229,
0.019277181,
-0.008459578,
0.011923343,
-0.021968259,
-0.0075536706,
0.007753503,
-0.011517016,
0.020183088,
-0.03314556,
-0.014494522,
-0.023740107,
-0.018770939,
0.02290081,
-0.010318021,
-0.0051390273,
0.012016598,
-0.021328796,
-0.012183125,
-0.03935369,
-0.013868379,
0.028003203,
0.012309685,
0.011956648,
0.02019641,
0.014188112,
0.02099574,
0.011303862,
-0.00014050727,
-0.030427838,
0.00079142017,
-0.008799294,
0.046227932,
-0.012696029,
0.013641902,
-0.00656783,
0.004719379,
-0.018491173,
0.029308775,
-0.01817144,
-0.010258071,
0.005825119,
0.009611946,
-0.01025141,
-0.017052379,
-0.022008225,
-0.018491173,
-0.016039893,
0.027270483,
0.0051889853,
-0.01815812,
0.02111564,
-0.009818439,
-0.0065345247,
-0.011956648,
0.024126451,
0.01172351,
0.0040133037,
0.005798475,
-0.028562734,
0.0010241419,
-0.016972445,
-0.012722673,
-0.0080532525,
-0.014134822,
-0.0060615875,
0.011237251,
-0.005132366,
-0.0129358275,
0.014414588,
-0.014068212,
-0.026790885,
0.0056885667,
0.0042098057,
-0.02227467,
0.0020699322,
0.013988279,
-0.011530339,
0.00031098942,
0.01055782,
0.0040965676,
0.009738507,
0.029921595,
-0.015080697,
-0.015147308,
0.028935755,
0.0032689276,
-0.013655225,
0.0026044843,
0.008912532,
-0.019570269,
-0.013495359,
0.020596076,
0.011470389,
-0.022874167,
-0.010817602,
-0.056699157,
0.021795072,
0.031999853,
0.014081534,
-0.010457904,
-0.019503657,
0.02768347,
-0.0037102245,
0.0067510097,
-0.007107378,
-0.008639428,
0.016506169,
0.0008059913,
-0.002529547,
-0.012329669,
-0.011983292,
0.04185826,
0.026857495,
0.03807476,
0.012442907,
-0.0070607504,
0.0083196955,
-0.014174789,
0.037968185,
0.00048625923,
0.011890037,
-0.03338536,
0.025498634,
-0.006967495,
-0.015014086,
-0.014694354,
-0.046973974,
0.005192316,
0.013402103,
-0.025005713,
-0.022674333,
0.013961635,
0.005695228,
0.025471989,
0.026684307,
-0.008999126,
-0.013115677,
0.054061368,
-0.00343712,
0.0037368687,
-0.0049258727,
-0.020795908,
0.009658573,
0.011243911,
-0.025218869,
0.020489499,
-0.0018651038,
0.009798456,
-0.024326283,
-0.022700978,
0.0006282236,
0.020449532,
0.019890001,
-0.027017362,
0.0031157227,
0.014041567,
-0.0071473443,
0.005235613,
-0.0073604994,
-0.009638591,
-0.005935027,
-0.017891675,
-0.014654388,
0.012023259,
-0.015120664,
-0.02092913,
0.01191002,
0.012109853,
0.0036369525,
0.0049358644,
0.019010738,
-0.019250536,
-0.0065578385,
-0.007420449,
0.005861755,
0.03271925,
-0.009631929,
-0.024872493,
0.028935755,
0.018397918,
0.0025029029,
-0.02676424,
0.02405984,
0.008159829,
-0.0024296308,
-0.00019431635,
0.009252247,
0.006264751,
0.006008299,
-0.001556196,
0.016799256,
0.0069208676,
-0.005715211,
-0.0038234629,
0.012616095,
-0.0028193044,
0.015054053,
-0.010897536,
-0.036902413,
-0.00032847477,
0.010038256,
-0.03780832,
-0.012049903,
0.0003621965,
0.008579478,
0.036529392,
0.0049125506,
-0.017651876,
0.0023413715,
0.003933371,
-0.0015362127,
-0.002885915,
-0.015520329,
-0.016759291,
0.00736716,
0.005818458,
0.016506169,
0.016119827,
0.0052955626,
0.0005299726,
-0.010238088,
0.028775888,
0.0048192954,
0.0084862225,
-0.0019999908,
0.002835957,
-0.010764314,
-0.022381246,
-0.0028526098,
0.0076469257,
-0.02731045,
-0.0013988279,
0.0257784,
-0.012902522,
0.08590136,
0.0043929857,
-0.009165653,
-0.013342153,
-0.0041531865,
0.014947475,
-0.0056386087,
0.027363738,
0.008392967,
-0.009838423,
0.0020416225,
-0.013482036,
0.010704364,
-0.049931496,
-0.025205547,
0.005628617,
0.0060782405,
0.03399818,
0.005781822,
0.018437885,
0.023127288,
0.010697703,
-0.02651112,
-0.007520365,
-0.016959123,
-0.0044595967,
0.0052855713,
-0.029841661,
-0.009958322,
-0.020769265,
-0.0021098987,
0.013335492,
-0.033465292,
-0.015440396,
0.033545226,
-0.022447858,
-0.008459578,
-0.029761728,
-0.006574491,
-0.011423761,
-0.014308011,
0.026870817,
-0.020849196,
-0.012223091,
-0.02405984,
-0.00951203,
-0.018144796,
0.0068409345,
-0.019929968
] |
BACKGROUND AND PURPOSE There are only few small studies assessing potential risk factors, comorbidity, and prognostic factors in adult spontaneous cervicocerebral artery dissection (CAD). METHODS We conducted a retrospective, hospital-based analysis on the prognostic factors and association of CAD with vascular risk factors in 301 consecutive Finnish patients, diagnosed from 1994 to 2007. RESULTS Two thirds of the patients were men (68%). Women were younger than men. Migraine (36% of all patients), especially with visual aura (63% of all migraineurs), and smoking were more common in patients with CAD compared with the
|
[
-0.011126052,
-0.010335604,
0.045513857,
-0.030130014,
-0.03597534,
0.0097245015,
-0.009518586,
0.00062314194,
-0.02633055,
-0.0160348,
0.00028043464,
0.03937626,
-0.0020740954,
0.013178559,
-0.009963629,
0.013470826,
0.043627407,
-0.005453426,
0.014334341,
-0.021494867,
-0.013397759,
0.009990199,
-0.01639349,
-0.0029143614,
-0.006732092,
0.028349845,
0.019608421,
-0.026237555,
-0.0038658879,
-0.02874839,
0.008190103,
-0.006399971,
-0.003945597,
-0.024563666,
-0.008415945,
0.028084148,
0.0049984204,
0.004048554,
0.0009888902,
-0.00003871285,
0.00052184507,
-0.017535986,
-0.0035603365,
-0.009139969,
-0.014015504,
0.00013326353,
-0.009179823,
-0.010787289,
-0.02007339,
0.028615542,
0.02540061,
0.0092329625,
-0.020578215,
0.014626606,
0.009697932,
-0.015118145,
-0.0016207503,
0.005646056,
0.013384474,
-0.045354437,
0.0009340902,
0.010528234,
-0.014693031,
0.0041116574,
-0.0338232,
-0.00083030236,
0.017775113,
0.011637518,
0.02262408,
0.012321687,
0.042219214,
0.026875228,
-0.010561447,
-0.003457379,
0.031006813,
-0.014507043,
-0.026144562,
-0.021083038,
-0.009770999,
0.006120989,
0.008229957,
-0.0311928,
0.008489012,
0.016685756,
-0.0004525148,
0.004706154,
-0.013962365,
0.0067653037,
-0.024364393,
-0.0082498845,
-0.003600191,
0.003975488,
-0.0074727214,
0.0003838073,
0.0037529669,
0.005088093,
0.012148985,
0.0049685296,
-0.0015526655,
-0.012959359,
-0.010116404,
-0.015994946,
-0.028270135,
-0.01436091,
-0.037994638,
-0.0035769427,
-0.024204975,
0.0023480952,
0.01930287,
-0.003806106,
0.004755972,
0.046629783,
-0.02007339,
-0.0028329918,
0.0037363607,
-0.019555282,
-0.0075524305,
-0.0017751865,
-0.0014530292,
-0.0124811055,
0.019023888,
-0.013895941,
0.014865734,
-0.023461023,
0.012740159,
0.0062040193,
-0.01521114,
0.013052354,
0.0044006025,
-0.012348257,
-0.031591345,
-0.012155627,
0.012879651,
-0.011265542,
-0.010455168,
0.00623391,
-0.03432802,
0.0026536465,
-0.019781124,
-0.0338232,
-0.007891194,
0.021096323,
-0.026808804,
-0.02625084,
-0.0188379,
0.013776377,
0.02874839,
0.010222683,
0.009970271,
0.001776847,
0.014135067,
-0.032627564,
0.0045400932,
-0.0008709872,
-0.01164416,
0.004061839,
-0.009797568,
0.022863206,
-0.012547529,
-0.0073730852,
-0.0032796944,
0.015649538,
-0.0032963005,
-0.009186465,
0.0147461705,
0.010262538,
-0.014321055,
-0.0020309195,
0.0134243285,
-0.020817341,
-0.022238819,
0.03435459,
-0.0164732,
-0.0149720125,
0.019940542,
0.0075856424,
-0.013842802,
0.008993835,
-0.032308728,
-0.035550226,
-0.025334187,
-0.0014762776,
0.044504207,
0.0061077042,
-0.013318051,
0.010229325,
0.038074344,
-0.021162746,
-0.0010046659,
-0.030980242,
-0.013643528,
0.021441728,
-0.006639098,
-0.0038160698,
-0.64192337,
-0.011245616,
-0.0018665198,
-0.006692237,
0.013895941,
0.023686867,
0.0031186158,
0.010003483,
-0.0026071495,
0.016951453,
-0.006815122,
0.01644663,
0.009525229,
0.008615217,
-0.013988934,
-0.014015504,
0.0062405528,
0.00033129065,
0.01518457,
-0.000248468,
0.010375459,
0.036639582,
-0.005210978,
0.024616806,
0.021641001,
0.0082498845,
0.0045234873,
-0.02589215,
-0.0088543445,
0.017934531,
0.011205761,
0.02671581,
-0.0011649142,
0.026091423,
0.049685296,
-0.026968222,
-0.0084026605,
0.014600037,
0.004945281,
0.038100917,
-0.023925994,
0.002844616,
0.01436091,
-0.0015767443,
-0.017748544,
0.01963499,
0.024125267,
-0.004865572,
0.003470664,
0.0031119734,
-0.0043009664,
-0.0048091114,
-0.013364547,
-0.020525075,
-0.00483236,
-0.015968375,
0.03116623,
-0.042139508,
-0.010402028,
0.011298755,
-0.0072535216,
0.008900842,
0.01029575,
-0.010169543,
-0.0036101548,
0.019369295,
-0.010302392,
-0.011803579,
0.00064971164,
-0.014453904,
0.014214776,
0.018957464,
0.010315677,
-0.02130888,
0.028429553,
0.025679592,
0.010800573,
0.021587862,
-0.029997164,
-0.021813704,
0.00096315076,
0.00941895,
-0.01727029,
0.008641787,
0.012773372,
-0.0025739374,
-0.024723085,
0.0126338815,
0.0034839488,
-0.011737155,
0.0005330541,
-0.0169116,
-0.0056825895,
-0.030927103,
0.00532722,
0.029093796,
0.0011275506,
0.012388112,
0.0053670746,
-0.01855892,
-0.021760564,
-0.02007339,
-0.012567457,
-0.0025639737,
-0.0015260958,
0.01754927,
-0.03674586,
-0.022610795,
0.04261776,
-0.033344943,
0.0011424961,
-0.011019773,
0.018731622,
-0.03220245,
0.004961887,
-0.025108345,
-0.008037327,
0.00089672656,
0.014759455,
-0.005101378,
-0.0057656197,
0.016805321,
-0.010196113,
-0.039110564,
0.02048522,
-0.0034939125,
-0.0045899116,
-0.01065444,
0.001331805,
-0.023647012,
0.010601301,
0.001600823,
0.028456124,
-0.008223315,
0.014201492,
-0.020883765,
0.011126052,
-0.008947339,
-0.022743642,
-0.013072281,
-0.03209617,
0.008794563,
0.0019628347,
0.0016381866,
-0.026596246,
0.0039256695,
-0.004609839,
0.0057656197,
-0.022756929,
-0.010481738,
0.0061907344,
-0.025480319,
-0.010893567,
0.020471936,
0.013570462,
0.00051520264,
0.013616959,
-0.0058752196,
0.008582005,
-0.011624234,
-0.015065007,
-0.0013019141,
-0.022916345,
0.0123283295,
-0.020671207,
-0.018970748,
-0.0015493443,
0.00615088,
-0.00026507405,
-0.030794255,
-0.0040817666,
-0.0012097505,
0.014533613,
0.017974386,
-0.013935795,
0.016194217,
0.0053770384,
-0.019541997,
-0.0058918255,
0.00060155406,
-0.010395386,
-0.027207348,
-0.012613954,
-0.0075657154,
0.022491232,
0.025560029,
0.025918718,
0.0013542232,
-0.00047078147,
0.0069346856,
-0.010700937,
0.017695405,
-0.0344343,
0.002474301,
-0.008396017,
0.009405665,
0.011338609,
0.0003223649,
-0.0129327895,
0.033026107,
0.043255433,
-0.0019811015,
0.020325802,
0.02045865,
0.019834263,
-0.00988392,
0.0022833315,
0.004148191,
0.018027525,
-0.0033411367,
0.017124156,
-0.0023896103,
-0.009751071,
-0.0057722623,
-0.023275036,
0.0064730374,
0.011145979,
-0.002979125,
-0.001029575,
0.0031734158,
-0.012381469,
-0.0064564315,
0.024762938,
-0.0051777656,
0.007034322,
0.022836637,
-0.003806106,
-0.0029293068,
0.0151978545,
-0.025799155,
-0.017323429,
0.034115463,
-0.0112721855,
0.018293222,
0.010973277,
0.021335451,
-0.0049851355,
-0.0069346856,
0.0128198685,
0.026835373,
-0.0049087475,
0.0121423425,
-0.0020475257,
-0.00927946,
0.012607312,
-0.015862096,
0.030501988,
0.0114781,
0.005533135,
0.03198989,
0.014135067,
-0.0042112935,
0.013630244,
0.0197147,
-0.0061708074,
0.00053554506,
0.0116973,
-0.0023397922,
0.031059952,
0.031697623,
0.03626761,
0.022172395,
-0.006114347,
0.0028014402,
0.009392381,
0.0060678497,
-0.00037073,
0.013251626,
-0.0018117198,
-0.014440619,
-0.0061409166,
0.0089672655,
-0.0050017415,
-0.040811025,
0.009020405,
0.003958882,
-0.0028894523,
0.019927258,
0.015583115,
0.02265065,
-0.004709475,
-0.035789356,
0.017389853,
0.02051179,
-0.011006488,
-0.016539624,
0.03028943,
-0.00085604173,
-0.01968813,
0.021986406,
0.00075640547,
0.016313782,
-0.019874118,
-0.0067619826,
0.011710585,
-0.004281039,
0.029226644,
-0.0030986886,
0.006024674,
-0.017788399,
-0.0087414235,
-0.013218414,
-0.012979287,
-0.015822243,
0.0075723575,
0.01966156,
0.0036898637,
0.0007784085,
-0.0014364232,
-0.017589126,
0.007273449,
-0.016606048,
-0.015025152,
0.013909225,
-0.009133326,
0.015343988,
-0.025387326,
-0.008953981,
0.027140925,
0.009040332,
0.008914126,
-0.0017137441,
-0.004168118,
-0.017177295,
0.04516845,
0.0052707596,
-0.002432786,
0.021548007,
0.011471458,
-0.003457379,
-0.002995731,
-0.026861943,
0.032441575,
0.020764202,
0.0075524305,
-0.014294486,
0.025493605,
0.024284685,
0.025214624,
0.030661406,
-0.0073797274,
-0.014786025,
0.00085687207,
-0.0080174,
-0.012202124,
0.00033731034,
0.04407909,
0.04848966,
0.02460352,
-0.021109607,
-0.014786025,
0.04445107,
-0.0018382894,
0.004755972,
-0.026051568,
0.04583269,
-0.022876492,
0.043202292,
0.010123047,
-0.01043524,
0.020219523,
-0.0058054742,
-0.012992572,
0.034673426,
0.05016355,
0.004769257,
0.01109284,
0.009591653,
0.014865734,
-0.026117992,
0.035683077,
-0.011856718,
0.022610795,
-0.022145825,
0.026303979,
0.013225056,
0.01958185,
-0.010162901,
0.02957205,
-0.013112135,
-0.0018366289,
0.0007339873,
-0.0010304053,
0.006848334,
-0.009113399,
-0.0039057424,
-0.0016348654,
-0.014453904,
0.008077182,
-0.0040850877,
-0.022677219,
0.004028627,
-0.018957464,
-0.009066902,
-0.00068333885,
0.0122154085,
-0.029811177,
0.007718491,
0.0009457144,
0.038818296,
0.03448744,
-0.035523657,
-0.003882494,
0.030501988,
-0.020126529,
-0.0027001433,
-0.007286734,
-0.018226799,
-0.020631354,
0.017947817,
-0.024085412,
-0.030050304,
0.0018449319,
0.022969484,
-0.00096647197,
-0.008276454,
-0.0072668064,
-0.03366378,
0.010886925,
0.00033191338,
0.017057732,
0.011796936,
-0.01683189,
-0.013882656,
0.027791882,
-0.04596554,
0.0010868658,
-0.023713436,
-0.013377832,
-0.0031883612,
-0.021587862,
-0.02468323,
0.019595137,
-0.010853712,
-0.0023829679,
0.006941328,
0.0112589,
-0.019475572,
0.026848657,
0.0045932326,
0.008927411,
0.023022624,
0.029040657,
0.0030322643,
0.010946707,
0.009153253,
0.028137287,
-0.0062970133,
-0.008555436,
0.039881084,
0.028960947,
-0.032255586,
-0.039748237,
-0.015808957,
0.009319314,
0.0453013,
-0.013709953,
-0.022331813,
-0.03371692,
-0.006037959,
0.013723237,
0.0012421324,
-0.024271399,
0.0069811824,
-0.015131431,
0.030156583,
-0.016101224,
-0.017788399,
0.039721668,
-0.032654133,
-0.013145347,
-0.025626453,
-0.022012977,
0.018359646,
-0.025719447,
0.0007348176,
-0.01765555,
-0.015848812,
0.0007788236,
-0.041368987,
-0.0008867629,
-0.006519534,
0.022863206,
0.0038991,
0.041528404,
0.021933267,
0.02045865,
0.026117992,
0.0042710756,
0.0024892467,
0.0062737647,
0.004071803,
-0.013696668,
0.03616133,
0.0044935965,
0.0032996216,
-0.00042137847,
-0.0114781,
0.015702678,
0.037569523,
-0.016632617,
-0.029146936,
-0.0033975975,
-0.040518757,
-0.004732724,
-0.012753445,
0.0025922041,
0.0007580661,
-0.04174096,
0.016048085,
0.031378787,
0.002441089,
-0.0048057903,
-0.021494867,
0.02959862,
0.0009357508,
0.014879019,
0.0013949081,
0.01087364,
0.02087048,
0.009711217,
0.0035470517,
0.0121024875,
0.025520174,
0.007944333,
0.016606048,
0.03191018,
-0.005210978,
-0.023673581,
0.021069754,
-0.026901796,
0.019541997,
0.008508938,
-0.02581244,
-0.015862096,
-0.026596246,
-0.016619332,
-0.00947209,
0.011544525,
0.0112721855,
-0.013225056,
0.01696474,
-0.030767685,
-0.007818127,
-0.012740159,
-0.026928367,
0.021853559,
-0.017961102,
0.04195352,
-0.0062704436,
-0.028987518,
-0.014400764,
0.020285947,
0.019900687,
-0.009292744,
0.0055597047,
0.02009996,
0.0005666814,
0.00051852386,
-0.011139337,
0.030714545,
-0.026569676,
-0.03701156,
0.044397928,
0.018399501,
-0.0031152945,
0.0055763107,
-0.018293222,
-0.011411676,
0.03369035,
-0.016672472,
-0.019874118,
0.020405512,
-0.02262408,
0.014573468,
0.024125267,
-0.047958266,
0.013530607,
-0.0051810867,
-0.0038791727,
0.012281833,
0.0038426395,
-0.0064431466,
-0.0003478967,
0.009863992,
0.020086676,
-0.0074727214,
0.0014505383,
-0.00760557,
0.0030007127,
-0.018333077,
0.013052354,
-0.008860987,
0.042936597,
0.018731622,
-0.008562078,
0.011816864,
-0.009624865,
-0.0049652085,
-0.0061077042,
-0.02265065,
-0.04009364,
-0.014533613,
-0.01394908,
0.035683077,
0.0011989566,
-0.015476837,
0.00064929645,
-0.022411522,
-0.006768625,
-0.019449003,
-0.010926779,
-0.001056975,
-0.03135222,
-0.0072203097,
0.009066902,
-0.013371189,
0.018319791,
0.019900687,
-0.002298277,
-0.0028213675,
0.0023115617,
-0.027765311,
0.016818605,
0.022677219,
0.010109762,
-0.023740007,
0.010395386,
-0.005337184,
-0.013391117,
0.009624865,
0.005513208,
-0.016207503,
-0.018147089,
-0.003168434,
0.0011541203,
-0.015556545,
-0.002823028,
0.031405356,
0.012148985,
-0.0060147103,
0.0016639259,
-0.021441728,
0.016486485,
-0.020352373,
-0.007293376,
0.012374827,
-0.02045865,
-0.0029724825,
0.0038426395,
0.0122154085,
0.0022401558,
-0.019913973,
-0.00008412001,
-0.025214624,
0.029811177,
-0.019754555,
-0.0021654286,
-0.003248143,
-0.006147559,
-0.024776224,
0.013105493,
-0.004882178,
-0.031006813,
0.010714222,
-0.01002341,
-0.01210913,
0.011936427,
-0.008415945,
-0.008568721,
0.001117587,
-0.014852449,
-0.013178559,
-0.0018416106,
-0.016194217,
0.0073531577,
0.014852449,
0.005423535,
-0.020897051,
-0.017004592,
-0.044796474,
0.00087845995,
-0.014015504,
0.028562402,
0.027366767,
0.017961102,
0.005234226,
0.013138705,
-0.00862186,
-0.0043175723,
-0.011405034,
0.00741294,
0.008655072,
-0.011099482,
0.030475419,
-0.007891194,
-0.025134914,
-0.02957205,
-0.007306661,
-0.002276689,
-0.0050183474,
0.012667093,
-0.014294486,
0.010634513,
0.009053617,
-0.010328962,
-0.013736523,
-0.0038858152,
-0.014427334,
-0.019608421,
-0.00348727,
-0.0074860062,
0.01809395,
0.019236445,
-0.0030106765,
-0.006619171,
-0.001422308,
-0.0015186231,
-0.019449003,
-0.014905589,
0.007897836,
-0.015689394,
-0.025546744,
0.0070808185,
0.012507675,
0.042139508,
0.008070539,
0.0016954775,
-0.0088543445,
0.0047858628,
0.0010162902,
-0.008555436,
0.012042706,
-0.020139815,
0.010866998,
-0.005164481,
0.007406297,
-0.0021239135,
0.0010553143,
-0.008887556,
-0.015928522,
-0.0233946,
0.022305243,
-0.006114347,
-0.0034939125,
0.008794563,
0.026410257,
-0.047851987,
-0.010302392,
-0.020033536,
0.0022584226,
-0.037489813,
0.0012288475,
0.00532722,
-0.012501033,
0.019674845,
0.032149307,
-0.014666461,
-0.027393335,
0.012540887,
0.18173659,
0.0043375,
-0.018319791,
0.008296382,
0.01249439,
0.006130953,
0.039482538,
0.0040319483,
-0.008907484,
0.019820979,
0.010182829,
-0.008203387,
-0.014719601,
0.008123678,
0.030555127,
-0.012288475,
-0.014095213,
-0.04115643,
-0.009100114,
-0.026343834,
-0.00059823284,
-0.007944333,
0.015051722,
0.00024535434,
0.008043969,
0.0044304933,
0.01026918,
-0.022398237,
0.04833024,
0.010016768,
-0.0033793307,
-0.0037629304,
0.0023995738,
0.0010030053,
-0.019608421,
-0.014759455,
-0.0024228224,
-0.0192763,
-0.0075059338,
-0.005609523,
-0.02125574,
-0.014440619,
-0.010441883,
0.017961102,
-0.025520174,
0.026529822,
-0.00017913774,
-0.03281355,
-0.016459914,
0.011298755,
-0.032229017,
-0.0026735736,
0.0015435321,
0.000069122674,
-0.030050304,
-0.009312672,
0.031724192,
0.0048755356,
-0.003503876,
0.000724854,
-0.008163533,
-0.008143606,
-0.020857196,
0.014081929,
-0.01068101,
0.023819715,
-0.011238973,
-0.010249252,
-0.021680856,
-0.016898314,
0.011564451,
-0.028509263,
-0.009963629,
0.007764988,
0.0048954627,
-0.010880282,
0.037968066,
0.0050017415,
0.005802153,
-0.002504192,
-0.011617591,
-0.01556983,
-0.007950976,
0.0057722623,
-0.023235181,
-0.019741269,
0.0052973293,
0.03775551,
-0.00151032,
-0.01521114,
-0.0048091114,
-0.0054733534,
-0.0008510599,
0.002916022,
0.010096477,
0.011185833,
-0.014174922,
-0.020060105,
0.009877278,
0.020644639,
-0.027087785,
0.06467059,
0.011982924,
-0.009850708,
-0.008316308,
0.024231546,
-0.027008075,
0.03135222,
0.013171917,
-0.020843912,
-0.007326588,
-0.006828407,
-0.0040983725,
-0.010149617,
-0.021441728,
0.0140287895,
0.009372453,
-0.027061215,
0.0010245931,
-0.0076188548,
-0.015383842,
-0.032361865,
0.012899578,
0.036799002,
-0.0052873655,
-0.018465925,
-0.008309666,
-0.01729686,
-0.0052740807,
-0.032521285,
0.006795195,
-0.02421826,
-0.0044637057,
0.0155034065,
0.024125267,
0.010548161,
0.0038160698,
-0.002441089,
0.005264117,
0.015689394,
0.003978809,
-0.006914758,
0.01855892,
0.013517323,
0.0021455013,
0.014042074,
-0.0140287895,
0.0016630957,
-0.022969484,
0.00090918114,
-0.029731467,
0.004563342,
-0.0020873803,
0.004041912,
0.04431822,
-0.010933422,
0.008562078,
-0.020498505,
-0.011464816,
0.009850708,
0.0006567692,
0.016725611,
0.04352113,
-0.0018847864,
0.020737633,
-0.0033843126,
-0.166645,
0.00906026,
-0.022849921,
-0.018439356,
0.03198989,
0.01768212,
0.009531871,
-0.008508938,
-0.005137911,
-0.013517323,
0.010302392,
0.016645903,
0.01924973,
0.0023165436,
0.012454536,
0.0011209082,
-0.010182829,
0.031378787,
0.013264911,
0.025347471,
0.0061110253,
-0.020684494,
0.007319946,
-0.015065007,
-0.010275822,
-0.021680856,
-0.021986406,
0.01762898,
-0.018930895,
-0.018000955,
0.0023265074,
0.0068881884,
0.0353111,
0.0010710901,
-0.011179191,
-0.008774635,
-0.03113966,
-0.028349845,
0.002605489,
-0.004453742,
0.016539624,
0.02965176,
0.018200228,
-0.018266652,
-0.00074810244,
0.011318682,
0.021229172,
-0.0326807,
0.014600037,
0.00022584225,
0.01024261,
-0.019541997,
0.017841538,
0.004443778,
0.000051349012,
0.027419906,
0.0044869543,
-0.0043341783,
0.013583747,
-0.022770213,
-0.0069014733,
-0.008415945,
0.023128903,
0.031485066,
-0.011664088,
-0.03751638,
-0.0024809435,
-0.0017320107,
-0.013039068,
0.035603367,
-0.026901796,
-0.0144804735,
-0.0049087475,
-0.030581698,
0.029279783,
0.013550535,
-0.005768941,
0.02092362,
-0.016924884,
-0.02718078,
-0.007087461,
0.013244984,
-0.023620442,
-0.0071538854,
-0.0024062162,
0.0013301445,
0.005609523,
-0.0051744445,
0.02051179,
-0.023992417,
0.01683189,
-0.03462029,
0.003945597,
-0.010594659,
-0.006519534,
0.02954548,
-0.01026918,
-0.025692876,
0.0037164334,
-0.00903369,
-0.006725449,
-0.00842923,
-0.02792473,
0.004516845,
0.021933267,
0.0053039715,
-0.0022667255,
0.020432081,
0.0046662996,
-0.0040817666,
0.0019927258,
0.004330857,
0.0201531,
-0.0014505383,
-0.001735332,
0.009259532,
-0.013962365,
0.0027399978,
-0.0008464933,
-0.0033826518,
0.053033073,
-0.0020325803,
0.008827775,
-0.009678004,
0.0067553404,
-0.00085936295,
-0.12997885,
-0.007273449,
-0.005632771,
0.029200073,
-0.0004973511,
0.014626606,
-0.01356382,
0.035071973,
0.0018266652,
0.018014241,
-0.028934378,
-0.021601146,
-0.0018432713,
-0.018585488,
0.045354437,
-0.032733843,
-0.0029127009,
-0.022252103,
-0.027446475,
0.021601146,
-0.010475094,
0.006436504,
-0.0082498845,
-0.028854668,
-0.020684494,
0.001334296,
-0.0027167494,
0.007944333,
0.015357273,
0.020883765,
-0.011624234,
0.0031335612,
-0.0016074654,
0.022026261,
-0.017575841,
-0.017429708,
0.017894678,
-0.050429247,
0.034274884,
-0.031644486,
0.028456124,
0.019183306,
0.026529822,
-0.015038437,
0.013118777,
0.0029807854,
-0.04670949,
0.0140287895,
0.01685846,
-0.029731467,
0.011969639,
-0.015131431,
0.0048423237,
0.002949234,
0.005423535,
0.001823344,
0.0058718985,
-0.0054633897,
-0.012879651,
-0.009591653,
0.0112589,
0.0047792206,
-0.009810853,
0.01353725,
0.019674845,
-0.041634683,
-0.0077716303,
-0.024510527,
-0.00044338146,
-0.011265542,
-0.010787289,
-0.006330225,
-0.0169116,
-0.006213983,
-0.0329464,
0.008761351,
-0.0013542232,
0.021840274,
-0.0059682135,
-0.0084757265,
-0.02419169,
-0.024975495,
0.011531239,
-0.0065992433,
0.019820979,
0.026264125,
0.004961887,
-0.017469563,
-0.003958882,
-0.024125267,
0.030209722,
0.03759609,
-0.003503876,
-0.011717227,
0.015529976,
0.024430817,
0.0048854994,
-0.000433833,
-0.0034042397,
0.014400764,
-0.01048838,
-0.00941895,
-0.05008384,
0.0055995593,
0.03358407,
-0.0069546127,
0.0020940227,
0.013909225,
0.022039546,
0.009106756,
-0.00055339653,
0.013278196,
-0.007811485,
0.023527449,
0.0028911128,
0.019834263,
-0.012288475,
-0.00023497558,
0.02416512,
0.0019595136,
0.039748237,
0.007824769,
-0.0070608915,
0.027552754,
0.0034972336,
0.031671055,
-0.011710585,
0.01606137,
0.0053338627,
0.036559876,
-0.01290622,
0.014108498,
0.0019927258,
-0.027366767,
0.0003451982,
0.012062633,
-0.010481738,
-0.013842802,
-0.004925354,
0.010993203,
0.024709798,
0.040837593,
-0.010574731,
-0.03036914,
0.015450267,
-0.016592763,
-0.014958728,
0.02097676,
-0.03286669,
0.014573468,
0.015370558,
-0.01438748,
-0.0012778353,
-0.006483001,
0.009306029,
-0.029811177,
-0.028349845,
0.033398084,
0.020086676,
0.008396017,
0.008801205,
-0.028482692,
0.02308905,
0.02213254,
0.0123681845,
0.003928991,
-0.0012421324,
-0.028376414,
-0.016273927,
0.008668357,
0.007492649,
-0.0072601642,
-0.015450267,
-0.019130167,
-0.0083628055,
0.016712327,
0.008575363,
0.0119895665,
-0.005616165,
0.015038437,
-0.028163858,
0.007877909,
-0.0068616187,
0.010162901,
-0.00862186,
0.021548007,
0.01150467,
0.019555282,
-0.020737633,
0.015397128,
-0.011637518,
-0.0007040964,
-0.026436828,
-0.0036035124,
0.0033328338,
0.021853559,
0.0052807233,
0.017416423,
-0.020192955,
-0.016366921,
0.02221225,
0.016566193,
-0.0060678497,
0.0061077042,
-0.025599884,
-0.021614432,
0.005433499,
0.00010690143,
-0.00842923,
-0.031883612,
-0.023447739,
0.0030804218,
0.040704746,
0.028349845,
-0.009604938,
-0.0020309195,
0.019727984,
-0.031006813,
-0.018665198,
0.0042378632,
-0.0016846835,
0.010030053,
-0.015397128,
0.026370404,
0.013895941,
0.0074727214,
0.015450267,
0.0077251336,
0.025599884,
-0.021003328,
0.02872182,
-0.022066116,
0.022876492,
0.0048921416,
-0.011657446,
-0.002012653,
0.0027117676,
-0.030634837,
-0.0050017415,
0.020750917,
-0.014135067,
0.07322603,
-0.0025091737,
-0.008409303,
-0.014679746,
-0.021508154,
0.0037131123,
0.003882494,
-0.0046995115,
0.017788399,
-0.019568566,
0.0034773063,
-0.014374195,
-0.0031767369,
-0.03600191,
-0.011391749,
0.004829039,
0.007638782,
0.023593873,
0.023647012,
-0.031086521,
0.011883288,
-0.02097676,
0.009697932,
0.005549741,
-0.018240083,
-0.013895941,
0.022969484,
-0.010787289,
-0.024975495,
-0.008223315,
-0.013484111,
0.008601933,
-0.021003328,
0.0022152467,
0.00645311,
0.0049818144,
-0.0012861384,
-0.025108345,
-0.009193108,
0.0062571587,
-0.031219369,
0.026888512,
-0.014055359,
-0.019143451,
-0.020272663,
-0.043122586,
0.003314567,
-0.021919983,
-0.01600823
] |
BACKGROUND Data on genetic susceptibility to sporadic gastric carcinoma have been published at a growing pace, but to date no comprehensive overview and quantitative summary has been available. METHODS We conducted a systematic review and meta-analysis of the evidence on the association between DNA variation and risk of developing stomach cancer. To assess result credibility, summary evidence was graded according to the Venice criteria and false positive report probability (FPRP) was calculated to further validate result noteworthiness. Meta-analysis was also conducted for subgroups, which were defined by ethnicity (Asian vs Caucasian), tumour histology (intestinal vs diffuse), tumour site (cardia vs non-card
|
[
0.0010556366,
0.0104107605,
0.03102711,
-0.0502205,
-0.039789885,
0.018187393,
-0.0234027,
0.0004155121,
-0.01624158,
-0.0036037248,
-0.022687912,
0.0044343355,
0.0094312355,
0.022714386,
0.0030659789,
0.003944573,
0.04707014,
0.0031321628,
-0.0136206895,
0.0039379545,
-0.024302805,
0.010331339,
-0.004659361,
-0.003530922,
0.004543539,
0.044078615,
0.010748299,
-0.023707148,
0.008729684,
-0.0035176855,
0.023985121,
0.0035838694,
-0.008570842,
-0.019616969,
-0.006310655,
-0.0054701166,
0.0065654637,
0.0048612226,
0.014335478,
-0.02431604,
-0.013177256,
0.007267015,
-0.006883147,
-0.019378707,
-0.009530512,
-0.01153589,
0.024011595,
-0.012396283,
-0.0021708386,
0.020344995,
0.009226065,
0.009464327,
-0.016029792,
0.0015164434,
-0.0143619515,
-0.019246338,
0.010960088,
0.011297627,
-0.007425857,
-0.029121008,
0.011264536,
0.011019654,
-0.030947689,
0.005681906,
-0.028644482,
0.008081079,
-0.023813043,
0.005188834,
0.010112932,
0.016956368,
0.033939213,
0.05421802,
-0.0136206895,
0.020768574,
0.0322449,
0.0011127203,
-0.008266395,
-0.010126169,
0.0031073438,
-0.0049969,
0.0013352644,
-0.0036335075,
0.024938172,
0.016837237,
0.001828336,
0.009967327,
-0.015447371,
0.005059775,
-0.011873429,
-0.012846336,
0.0012169603,
0.025851512,
-0.006863292,
-0.0016273018,
-0.010893905,
0.0047619464,
-0.009384907,
0.022145202,
0.0064794244,
-0.030285848,
-0.0066349567,
-0.0023627726,
-0.018306524,
-0.012713967,
-0.026804565,
-0.0073729097,
0.016254816,
-0.021827519,
0.008683355,
-0.0048413677,
-0.013051506,
0.02386599,
-0.01599008,
-0.008901763,
0.010218826,
-0.010232063,
0.028618008,
0.0015412624,
-0.005685215,
0.000775595,
0.0104173785,
-0.002495141,
0.04259609,
0.0031636003,
0.041669514,
-0.011972705,
-0.036639523,
0.010476944,
-0.0049108607,
0.0003274045,
0.0065787006,
0.016426897,
0.022145202,
0.027717905,
-0.028512115,
0.005301347,
-0.020212626,
-0.012938993,
-0.018941892,
-0.047467243,
0.011171877,
0.028882746,
-0.016043028,
-0.013256677,
-0.015513555,
0.004417789,
0.026010355,
0.02673838,
0.00072926615,
-0.008167119,
0.014309004,
-0.01903455,
-0.00041344386,
-0.002682111,
0.0055859387,
-0.007822962,
0.0049869725,
0.0038353691,
-0.014772293,
-0.02115244,
0.009583459,
0.0045633945,
-0.006360293,
0.021059783,
0.0014105488,
0.03356858,
0.010026893,
-0.023813043,
-0.0033340245,
-0.020027312,
-0.022687912,
0.028670955,
-0.032589056,
0.009140026,
-0.017022552,
-0.0026026901,
-0.013230204,
0.009477564,
-0.02811501,
-0.022793807,
-0.027294327,
0.020371469,
0.033886265,
0.007187594,
-0.001180559,
-0.018041788,
0.021681914,
0.0010928651,
-0.028670955,
-0.03544821,
-0.0020483981,
0.011932995,
0.01166164,
-0.005364222,
-0.6455333,
-0.027479641,
-0.015778292,
-0.012892664,
0.014719346,
0.02282028,
0.004060395,
0.021562783,
-0.016360711,
0.023707148,
-0.02194665,
0.01936547,
0.029650481,
-0.02136423,
-0.028856272,
-0.03902215,
0.019921416,
-0.012091837,
0.032668475,
-0.00383206,
-0.03430984,
0.026910458,
-0.0021245098,
0.002931956,
0.0004130302,
0.016956368,
0.0010440543,
-0.018147683,
0.012588218,
0.021708388,
-0.036030628,
0.011615311,
-0.022131966,
-0.004960499,
0.04526993,
-0.03531584,
0.00081820105,
0.035633523,
-0.0007044471,
0.028379746,
-0.0063867667,
-0.024501357,
0.031265374,
-0.0032463304,
-0.035633523,
0.01928605,
0.019219866,
0.0031751825,
0.008584079,
0.0014254402,
-0.0072405413,
0.004904242,
-0.016824,
-0.010470326,
0.03489226,
-0.0028459167,
0.019868469,
-0.031503636,
-0.010523274,
0.0011458123,
0.0016670122,
0.015857713,
-0.00034519148,
-0.023839517,
-0.017525552,
0.0139913205,
-0.007922238,
0.022780571,
0.025891224,
0.007935475,
0.009192972,
0.03168895,
-0.0062146876,
-0.004378079,
0.027876746,
0.04913508,
-0.0046659796,
0.013104454,
-0.022330519,
0.017525552,
0.0012897628,
0.005509827,
-0.01270073,
0.01740642,
0.021562783,
-0.0011094111,
-0.024474883,
0.010146024,
0.0025100324,
0.00249845,
0.013885426,
-0.0008579115,
-0.008484803,
0.0009092042,
-0.020622969,
0.018677155,
0.0030295777,
0.0061981417,
-0.0005509827,
-0.034203947,
-0.034918737,
-0.018584497,
0.013633926,
-0.009504038,
0.014322241,
0.0006138576,
-0.02060973,
-0.013580979,
0.024607252,
-0.020755336,
0.019471364,
0.013938373,
-0.0022122038,
0.0056157215,
-0.005430406,
-0.02790322,
-0.00040330942,
0.004977045,
-0.016916659,
-0.011628548,
0.007214068,
0.009603314,
0.001274044,
-0.015566503,
0.016890185,
0.020212626,
-0.006380148,
-0.014997319,
0.01095347,
-0.018968366,
-0.0019855232,
-0.008769395,
0.020795047,
-0.019974364,
0.0018051716,
-0.018134445,
0.014044268,
-0.012442612,
-0.013964847,
-0.02669867,
-0.029491639,
-0.018610971,
0.0075648436,
0.0024041377,
-0.012925756,
-0.0075317514,
-0.025785329,
-0.0068699103,
0.01878305,
0.022079019,
0.014216347,
0.00088521244,
-0.0058837673,
0.009834958,
0.0019954508,
-0.000048940045,
0.019272812,
-0.019047786,
-0.0012938994,
-0.029226903,
0.040372305,
-0.004235783,
-0.002440539,
-0.0071280287,
-0.00023433311,
-0.024792567,
-0.016109211,
0.00034457102,
-0.0026341276,
-0.026235381,
0.008809105,
-0.009815103,
0.0014163399,
0.017856473,
-0.016890185,
0.017777052,
-0.0056256494,
0.003911481,
-0.013289769,
-0.010457089,
0.006684595,
-0.024276331,
-0.010271774,
-0.0008310242,
0.050829396,
0.017472604,
0.031794846,
0.009861432,
0.01278677,
0.027373748,
-0.015540029,
0.0025563613,
-0.011436614,
0.0239057,
-0.013243441,
-0.0039677373,
-0.0071611204,
0.014653162,
-0.027161958,
0.03198016,
-0.007472186,
-0.014904661,
0.0009001039,
-0.01612245,
0.035474684,
-0.00753837,
0.023177674,
0.0053873863,
0.0025001047,
0.004431026,
0.013580979,
0.007988422,
-0.019484602,
0.0035408498,
-0.011145404,
0.010960088,
0.007889146,
-0.010066603,
-0.0083259605,
0.014586978,
0.015354713,
0.016850473,
0.024342515,
0.015037029,
-0.004073632,
0.002890591,
-0.002152638,
0.020755336,
0.009967327,
-0.0244087,
-0.013210348,
0.03211253,
-0.012032271,
0.0049009332,
0.033462685,
0.0031884194,
0.006691213,
-0.012469086,
0.009967327,
0.013111072,
0.0037327837,
-0.008425237,
0.00087776675,
0.00310238,
0.028167957,
-0.020186152,
0.025772091,
-0.0046957624,
-0.017803526,
0.0122705335,
0.009027513,
0.0122639155,
-0.01849184,
0.005238472,
0.004556776,
-0.051041186,
-0.007683975,
0.0044872826,
0.030947689,
0.018147683,
0.020331759,
0.0021642204,
0.0022833517,
-0.002273424,
-0.0024306113,
0.0022270952,
-0.0033952447,
-0.0010142715,
-0.006042609,
0.012740441,
-0.009834958,
-0.023826279,
0.015434134,
-0.045614086,
0.00170755,
0.008047988,
0.020662678,
0.013580979,
0.012217587,
-0.0016976224,
-0.01637395,
-0.040239938,
0.042543147,
0.027876746,
-0.003865152,
-0.009609933,
-0.0027615319,
0.006489352,
-0.013461848,
0.008822341,
0.016135685,
0.009643025,
0.008915,
-0.009947471,
-0.008550987,
0.00015129274,
0.006052537,
-0.01990818,
0.020847995,
-0.0044508814,
0.0066779763,
-0.013296387,
-0.015632687,
-0.004176217,
0.024223384,
0.016029792,
-0.0037427114,
0.01174768,
0.0100467475,
-0.014692872,
0.0066945227,
-0.0057414714,
-0.022065781,
0.0038883165,
0.001164013,
0.0013038269,
-0.008253158,
0.002478595,
0.026963405,
0.013508176,
-0.015778292,
-0.03428337,
-0.01703579,
0.0019971055,
0.03168895,
0.013051506,
-0.021986362,
0.000021664955,
0.035289366,
0.0010895559,
-0.0022502597,
-0.031503636,
0.02045089,
-0.016559264,
-0.00091582263,
0.0128860455,
0.010695352,
0.0029468474,
0.015685635,
0.02906806,
-0.005480044,
-0.016426897,
-0.022277571,
-0.0058870763,
-0.017565262,
0.010821102,
0.03986931,
0.038545623,
0.030709427,
-0.016797528,
0.008239921,
0.018134445,
0.0013029997,
0.0030957616,
-0.012171257,
0.016268054,
0.0056620506,
0.03131832,
-0.0039909016,
-0.018544788,
0.020411178,
-0.014520793,
-0.00035077578,
0.010761536,
0.015129687,
0.00970259,
0.019246338,
0.02927985,
0.023270333,
-0.0014419863,
0.008385527,
0.027003117,
0.0017340237,
-0.0128860455,
-0.007862672,
0.0048347493,
0.009517275,
-0.021192152,
0.029888744,
-0.005863912,
-0.012614691,
-0.014401662,
-0.024289567,
-0.013183874,
-0.012555125,
-0.0013410555,
0.008981183,
-0.0056024846,
-0.018915419,
-0.02536175,
-0.02869743,
-0.026354512,
-0.018544788,
-0.021602493,
0.011132167,
-0.030259375,
-0.008729684,
-0.0011524308,
0.027929693,
0.010198971,
0.007571462,
-0.02332328,
0.008610552,
0.018187393,
0.0047420915,
-0.019206628,
0.004285421,
-0.036057103,
0.0068302,
-0.003769185,
-0.0009861432,
0.0038386784,
-0.005897004,
0.023588017,
-0.005135887,
-0.005020065,
0.007154502,
-0.00441448,
0.00053236843,
0.007505278,
0.0041662897,
-0.002127819,
-0.000108169654,
-0.008716447,
0.002165875,
-0.024554305,
-0.03568647,
-0.02215844,
0.0049969,
-0.020821521,
-0.0086635,
-0.0038088954,
0.016254816,
-0.0070949364,
0.009649643,
-0.024382226,
0.0109137595,
0.0047420915,
0.030312322,
0.042543147,
-0.011985942,
0.023389464,
0.0002930715,
-0.017247578,
0.0032926593,
0.021298045,
0.030762374,
0.020715626,
-0.000155119,
0.007624409,
-0.013170637,
-0.015156161,
-0.023177674,
-0.0030345414,
0.008034751,
0.022065781,
-0.007280252,
-0.02194665,
0.0025050684,
-0.007624409,
0.0014196491,
0.021443652,
-0.016678395,
-0.019299285,
-0.024368988,
0.004202691,
0.0017704249,
-0.016466606,
0.026486881,
-0.030947689,
-0.006883147,
-0.013084598,
-0.015182635,
0.0073001073,
-0.0041001057,
-0.0023909009,
-0.027453167,
-0.0060624643,
-0.01004013,
-0.008425237,
0.01037105,
-0.017512316,
0.040848833,
0.025507355,
0.017750578,
-0.009404762,
0.013216967,
0.009868051,
-0.0022568782,
0.0016703214,
-0.005509827,
0.011377049,
-0.0020053785,
0.013911899,
0.0056785964,
-0.004801657,
-0.004315204,
-0.012919138,
0.022105493,
0.016321002,
-0.01798884,
-0.016612211,
-0.0051954524,
-0.021801045,
-0.025163198,
0.007558225,
-0.0050167553,
0.03595121,
-0.042887304,
0.0059962803,
0.01224406,
0.0049737357,
-0.00021840756,
-0.01149618,
0.025719145,
-0.019180154,
0.015884185,
-0.005810965,
0.0034713566,
-0.0068368185,
-0.01928605,
-0.016731342,
0.0043615326,
-0.0040670135,
-0.008167119,
0.047970243,
0.011324101,
-0.0038254415,
-0.0054866625,
0.006522444,
-0.005930096,
-0.00912017,
0.0132500585,
-0.017552026,
0.0030510875,
-0.0054039326,
0.02495141,
-0.0037956587,
-0.0014626688,
0.0012053781,
-0.014256057,
0.02285999,
-0.001899484,
-0.019736102,
-0.0064992793,
0.010304865,
0.02890922,
-0.020768574,
0.02473962,
0.02336299,
-0.006856674,
-0.033939213,
0.02244965,
0.01678429,
-0.0035209947,
0.023640964,
0.017724104,
0.007988422,
0.00064860424,
0.0027003116,
-0.005976425,
-0.04230488,
-0.015182635,
0.008438474,
0.00015873845,
0.023601253,
-0.017009316,
-0.004877769,
-0.020146443,
0.02332328,
0.0025067232,
0.012224205,
-0.0038750796,
-0.027373748,
-0.016387185,
0.026050065,
-0.016916659,
0.005350985,
0.009232683,
-0.010582839,
-0.016625447,
-0.021496598,
-0.01965668,
0.0028723902,
0.011363812,
0.04259609,
-0.0049869725,
0.0015321621,
0.0083193425,
0.011456469,
0.0037460206,
-0.01111893,
-0.014957609,
0.04169599,
-0.0136206895,
-0.0038419876,
-0.020411178,
0.008226684,
0.029465165,
0.0003036196,
-0.001139194,
-0.02698988,
-0.03036527,
-0.0072339233,
0.013389045,
0.016890185,
-0.0034515013,
0.0018763195,
-0.012277152,
-0.0023875916,
-0.013713348,
-0.028326798,
0.0066117924,
-0.021920176,
-0.0057149976,
-0.011846956,
0.004090178,
0.015195872,
0.033012632,
-0.0016041374,
-0.012932375,
0.022409938,
-0.03240374,
0.020067021,
0.01769763,
-0.015010556,
-0.03131832,
0.03544821,
-0.018610971,
-0.020212626,
0.010596076,
-0.00995409,
-0.007882527,
-0.048790924,
-0.015897423,
0.018425656,
-0.00953713,
-0.020874469,
0.002644055,
0.01162193,
0.014070742,
0.0016711487,
-0.0012128238,
0.022754097,
-0.021576019,
0.021576019,
0.013521413,
0.0018713557,
0.015354713,
-0.03986931,
-0.0014312314,
0.0067375423,
-0.0011193388,
0.00924592,
0.0010192352,
0.020847995,
-0.0045402297,
0.008524513,
-0.004639506,
-0.0007350573,
-0.014163399,
0.010708589,
0.007088318,
-0.022304045,
0.007392765,
-0.00041199606,
0.006816963,
0.018213866,
-0.024117488,
0.0062643257,
0.00491417,
0.0047420915,
-0.028035589,
-0.002481904,
-0.019722864,
0.026036829,
0.027691431,
-0.0069559496,
-0.026460407,
0.0010655641,
-0.04018699,
-0.006896384,
0.006770634,
0.020146443,
0.01420311,
0.018558023,
-0.00079875946,
0.020424416,
-0.006922858,
0.004573322,
0.0016546027,
0.0086635,
-0.013342717,
-0.02303207,
0.043707985,
0.0057745636,
-0.021681914,
-0.026089776,
0.013117691,
0.015884185,
-0.029676955,
0.010344576,
-0.0047917296,
0.030788848,
-0.03814852,
-0.0029584297,
-0.0067110686,
0.013130927,
0.026328038,
-0.009126789,
-0.01095347,
-0.012972086,
0.004699072,
0.0010407451,
0.008008277,
0.000051060008,
0.0027846964,
0.011707969,
-0.025374988,
-0.035421737,
0.0070419894,
-0.014759056,
-0.008306106,
0.025269093,
0.010470326,
0.013594216,
-0.0015751818,
-0.006922858,
-0.028141484,
-0.01982876,
-0.007048608,
0.0077832513,
0.0139913205,
-0.010807865,
-0.016479842,
-0.012892664,
0.008418619,
0.0028062062,
0.006651503,
-0.001235161,
-0.032615528,
-0.010920378,
0.037460204,
0.003039505,
-0.002764841,
-0.006360293,
0.011363812,
-0.0375661,
-0.0054998994,
-0.019643443,
-0.012297007,
-0.028432693,
0.00824654,
-0.0038916257,
-0.006462878,
-0.0011780772,
0.004285421,
-0.03407158,
-0.029306324,
0.0151032135,
0.18171509,
-0.013885426,
-0.00026390914,
0.019140445,
0.0076310276,
-0.02303207,
0.025083777,
0.031847794,
-0.004963808,
0.013289769,
0.021258336,
-0.006942713,
0.0017935893,
0.0018630826,
0.032139003,
-0.008544369,
-0.03211253,
-0.013342717,
-0.016956368,
-0.0027731142,
0.014970846,
-0.03306558,
-0.027188431,
-0.004940644,
0.020186152,
-0.008478184,
-0.019391945,
-0.0136206895,
0.02507054,
-0.006797108,
-0.013150782,
-0.0050663934,
0.010198971,
0.009219446,
-0.028300324,
0.0030841795,
0.0018581188,
-0.005814274,
-0.0027036208,
-0.002744986,
-0.018928654,
0.01266102,
-0.027797326,
-0.011019654,
-0.027347274,
0.018280052,
0.00027611182,
0.0052484,
-0.0060591553,
-0.023190912,
-0.0419872,
-0.00066970044,
0.0059201685,
0.0040140664,
-0.024845514,
-0.013673637,
0.022515833,
-0.017379947,
-0.0046957624,
0.0066349567,
-0.000011149178,
0.010390905,
-0.032430213,
0.01715492,
-0.030762374,
0.016188633,
0.00904075,
0.012819862,
-0.0084450925,
-0.015751818,
0.010874049,
-0.033462685,
-0.014759056,
0.0072074495,
-0.017141685,
-0.0040703225,
0.018888945,
0.011615311,
0.02219815,
0.005926787,
0.0037791126,
0.0012781806,
-0.018955128,
-0.0019358852,
-0.020106733,
-0.04307262,
0.014719346,
0.022462886,
-0.0073729097,
-0.030312322,
-0.012654401,
0.01907426,
0.0026523282,
-0.019736102,
0.0076773567,
0.0038088954,
-0.0033472613,
0.01536795,
-0.008967946,
-0.013872189,
-0.029253377,
0.07597936,
-0.016929895,
0.004649434,
-0.022833517,
0.0060161357,
-0.029173955,
0.029465165,
0.03052411,
0.011516035,
0.00637353,
0.0015578085,
0.0041199606,
-0.016890185,
0.007055226,
0.021470126,
0.017552026,
-0.040081095,
0.023151202,
-0.025970643,
-0.017393183,
-0.024011595,
0.013296387,
0.027797326,
-0.011006418,
0.0014270948,
-0.000483144,
0.0064297863,
-0.0026242,
-0.043760933,
0.006730924,
-0.027691431,
0.002577871,
-0.0005112722,
0.0055627744,
-0.013296387,
0.0046163416,
-0.014878187,
0.0032397122,
0.008127408,
0.0019524312,
-0.0024273023,
0.008173738,
0.013415519,
-0.029544586,
0.0024637035,
0.013475085,
0.020318521,
-0.015156161,
-0.0010688733,
-0.007346436,
-0.010768155,
-0.026301565,
0.019047786,
0.022105493,
-0.01953755,
-0.023707148,
-0.042543147,
0.008881907,
-0.002152638,
-0.008306106,
0.009411381,
0.05143829,
-0.0037460206,
-0.0067739435,
0.009868051,
-0.16720754,
0.034045104,
0.009073841,
-0.030682953,
0.027506115,
0.019378707,
0.024117488,
-0.00012699075,
0.022171676,
0.020649442,
0.022648202,
0.005976425,
-0.02790322,
-0.025467645,
0.008147264,
0.0017919347,
-0.03777789,
0.03436279,
0.018769814,
0.015685635,
0.016135685,
-0.019709628,
0.019802285,
-0.015142924,
0.010516655,
0.023508595,
-0.018849235,
0.014110452,
-0.029226903,
-0.0033141694,
0.0014221311,
-0.014269294,
0.019140445,
-0.023958648,
-0.0035375406,
0.0023478812,
-0.020292047,
-0.0044674273,
-0.0059830435,
-0.0104968,
0.032853793,
0.03560705,
0.028300324,
-0.02219815,
-0.0118271,
0.022211388,
0.014520793,
-0.023588017,
0.022793807,
0.000517477,
-0.0020599803,
0.007988422,
0.03065648,
-0.0035375406,
0.008312724,
0.002566289,
0.0014006211,
-0.0055859387,
0.012555125,
-0.020411178,
0.0016008281,
-0.019762576,
0.028167957,
0.008292869,
-0.008173738,
-0.02935927,
-0.024064543,
-0.0033092054,
-0.0030957616,
0.004510447,
-0.010867431,
0.018359471,
0.00399752,
-0.019140445,
0.018624209,
-0.004086869,
0.0022998978,
0.0010663915,
0.0001853155,
-0.017274052,
-0.01507674,
0.0024967955,
-0.018266814,
-0.029173955,
0.015050266,
0.03798968,
0.01511645,
0.005503209,
-0.007061844,
-0.0042291647,
0.041828357,
-0.019312523,
0.010099695,
-0.012581599,
0.027850272,
0.008795868,
-0.004510447,
0.015023793,
-0.012224205,
-0.0151032135,
-0.0012426067,
-0.025480881,
-0.044210985,
0.0076575014,
0.03378037,
-0.002569598,
-0.0023875916,
0.016837237,
0.040266413,
-0.010821102,
-0.005284801,
-0.0024752857,
0.012131548,
0.020543547,
-0.015394424,
0.033462685,
-0.02469991,
-0.018412419,
-0.016148923,
0.003881698,
0.04323146,
-0.010331339,
0.015182635,
-0.007458949,
0.008623789,
-0.012800006,
-0.116378136,
0.004649434,
0.0028707357,
0.009550367,
-0.010847575,
0.015526792,
-0.012469086,
0.0044210986,
-0.012892664,
0.0443963,
-0.003398554,
-0.021549545,
-0.02215844,
-0.024263095,
-0.0013402282,
-0.005476735,
0.0028707357,
-0.016095975,
-0.021853993,
0.029782848,
0.0049505713,
0.00068872835,
-0.0111520225,
-0.0019458128,
-0.0048380583,
0.0009977254,
-0.024911698,
0.009583459,
0.013415519,
0.010251919,
0.005718307,
0.004199382,
-0.0065290625,
-0.019762576,
-0.041034147,
0.0045832493,
-0.017327,
-0.04648772,
0.02644717,
0.0015255437,
-0.006525753,
0.013938373,
0.032139003,
0.009179736,
0.011059364,
-0.0038088954,
-0.02935927,
0.024501357,
0.014070742,
-0.02761201,
-0.005380768,
-0.03277437,
-0.0072868704,
-0.0076575014,
0.0029997947,
-0.030179953,
0.007849435,
0.01004013,
0.003085834,
0.0013195457,
-0.002898864,
-0.014083979,
-0.0204906,
0.0027979333,
0.016148923,
-0.01715492,
-0.0011516035,
-0.027823798,
0.0059698066,
-0.028220903,
-0.011317482,
0.005443643,
-0.029015113,
-0.0014419863,
-0.021589257,
-0.0053873863,
-0.030550584,
-0.0010457089,
0.019749338,
-0.038386784,
-0.0020351612,
-0.008848815,
0.013064743,
-0.021086257,
0.035209946,
0.0019557404,
-0.00945109,
-0.008842197,
-0.0007726995,
-0.01969639,
-0.015235581,
0.04709661,
0.004990282,
-0.022251097,
-0.010205589,
0.020146443,
0.01007984,
-0.0021344374,
-0.000066908,
0.0010531546,
-0.027717905,
-0.013435374,
-0.066819474,
0.0068302,
0.0053840773,
-0.021721624,
-0.0015445716,
0.008047988,
0.018280052,
0.005440334,
-0.002528233,
0.009398144,
-0.012978704,
0.017221104,
-0.024051305,
-0.020728862,
-0.015619449,
-0.030285848,
0.013263295,
0.015791528,
0.025507355,
0.048261452,
-0.0090672225,
0.028062062,
-0.0089348545,
-0.0016413659,
-0.0063669113,
-0.0054568797,
0.001345192,
0.021509835,
-0.018372709,
-0.047864348,
0.01936547,
-0.017803526,
-0.026394222,
-0.0012293698,
-0.0028045515,
-0.01649308,
0.008140645,
0.023680674,
0.034230422,
0.018597735,
-0.010933614,
-0.003261222,
0.00087942136,
0.009464327,
-0.009868051,
0.014375188,
-0.04963808,
0.006231234,
0.0070949364,
0.00791562,
0.028512115,
-0.0032347483,
0.02015968,
-0.03489226,
-0.00040951418,
0.01220435,
0.02324386,
0.022383466,
-0.02219815,
-0.033250894,
0.035527628,
0.019100733,
0.0005199589,
0.0076442645,
-0.01349494,
-0.0026175815,
-0.022767333,
-0.0072603966,
0.006400003,
-0.03597768,
-0.015910659,
0.0069030025,
-0.0009166499,
0.011866811,
-0.002478595,
-0.0071478835,
0.0042424016,
0.014851714,
0.011919758,
0.024779331,
-0.00041964863,
0.017432895,
-0.023561543,
0.04571998,
0.043840352,
0.008650263,
-0.0009737337,
-0.0026258545,
0.009179736,
0.02507054,
0.0044707367,
0.016625447,
0.009543749,
0.02444841,
0.01420311,
0.038201466,
-0.0041662897,
0.004136507,
0.022039307,
0.023376226,
0.010834338,
0.017432895,
0.0077700145,
-0.021483362,
0.004543539,
0.0034415736,
-0.013633926,
-0.029438691,
-0.0066349567,
0.0014725964,
0.033753894,
0.012833099,
-0.014004557,
-0.0034879025,
0.002994831,
-0.006492661,
0.0012715622,
-0.007650883,
-0.0032711495,
0.015976844,
-0.0029385744,
0.012065363,
0.022767333,
0.0014486046,
0.011668258,
0.010874049,
0.03269495,
-0.01674458,
0.029041586,
-0.024435174,
0.021271573,
0.004672598,
-0.018293288,
-0.022423176,
0.0047950386,
-0.019021314,
0.00222875,
0.0056620506,
-0.020874469,
0.0799504,
0.016625447,
0.013938373,
-0.003818823,
-0.010735063,
0.012416139,
0.019193392,
-0.0010093077,
-0.0065456084,
-0.027638484,
0.0055462285,
-0.018822761,
0.015606212,
-0.03531584,
-0.022807043,
0.030868268,
0.020662678,
0.002490177,
-0.016916659,
-0.027400222,
0.013713348,
-0.00001782576,
0.021139205,
0.018928654,
-0.031344794,
-0.008656882,
0.008564224,
0.015897423,
0.014573741,
-0.019775812,
-0.014917898,
-0.004967117,
-0.03436279,
-0.00483144,
0.020967126,
-0.012402902,
-0.009199591,
-0.04201367,
0.010655642,
0.019868469,
0.0019209938,
0.004576631,
-0.024077779,
-0.02244965,
-0.004255638,
-0.009199591,
-0.022846755,
-0.008531132,
-0.0016901767
] |
Neural signalling within the central nervous system (CNS) requires a highly controlled microenvironment. Cells at three key interfaces form barriers between the blood and the CNS: the blood-brain barrier (BBB), blood-CSF barrier and the arachnoid barrier. The BBB at the level of brain microvessel endothelium is the major site of blood-CNS exchange. The structure and function of the BBB is summarised, the physical barrier formed by the endothelial tight junctions, and the transport barrier resulting from membrane transporters and vesicular mechanisms. The roles of associated cells are outlined, especially the endfeet of
|
[
-0.005631094,
0.008253306,
0.010586327,
-0.020990692,
0.0014093982,
-0.009631023,
0.0020746992,
-0.008318293,
-0.0099299615,
-0.022784323,
-0.00667413,
0.013198791,
-0.008155826,
-0.0023590159,
-0.011099721,
0.00008138564,
0.028100232,
0.01295834,
-0.03940791,
0.017754355,
-0.032961234,
0.0066806288,
-0.006475921,
-0.02411005,
0.0008521376,
0.03342914,
0.004828509,
-0.025370792,
-0.0041591465,
-0.025500765,
-0.0054101394,
0.014972926,
-0.02674851,
0.013218286,
0.0160777,
0.012789374,
0.0015150015,
-0.0122564845,
0.031219592,
0.011795078,
0.015804756,
0.014219081,
-0.006638387,
0.014660991,
0.0075189564,
-0.006108746,
-0.014258074,
0.0022485384,
-0.03127158,
0.015570804,
0.039771836,
-0.0032607056,
-0.019989897,
-0.014790963,
-0.03623656,
-0.025097849,
-0.010846274,
0.01597372,
0.015661785,
-0.030127816,
-0.011658607,
-0.0059820223,
-0.020093875,
0.015843747,
-0.015921732,
-0.0053808955,
0.007590442,
0.024668936,
-0.0031161103,
0.0018586185,
0.015999716,
0.022082467,
-0.008558743,
0.017559396,
0.031011634,
-0.022888301,
-0.015427833,
-0.008968159,
-0.027320392,
-0.0032119658,
0.021861512,
-0.031193597,
-0.00662539,
0.031297576,
0.018079288,
-0.0001923199,
0.008168823,
0.0023541418,
0.009728503,
-0.0016595968,
0.008779698,
0.013322265,
-0.0016352269,
0.011411658,
0.012405953,
0.029633917,
0.00048374446,
0.039433904,
0.007668426,
0.006008017,
0.004623801,
0.0028675364,
-0.01003394,
-0.024227027,
-0.0140891075,
-0.008591237,
0.005728574,
0.0028285445,
0.0214326,
0.00964402,
0.00030807737,
0.022004483,
-0.01622067,
-0.030959645,
0.021562574,
0.031167602,
0.023577161,
-0.023122253,
-0.0017010259,
0.0060827513,
0.011795078,
0.026540551,
0.022771325,
-0.013868153,
0.027710311,
0.025968669,
-0.007473466,
-0.005231426,
-0.015466825,
0.00516319,
-0.019080084,
0.018547192,
0.014647993,
0.009520546,
-0.019184062,
-0.014024121,
-0.013647199,
0.009650519,
-0.026514558,
-0.015557806,
0.015063908,
0.036886428,
-0.023317214,
0.0023216484,
0.005949529,
0.03355911,
0.045360688,
0.017858334,
0.00677161,
-0.0011470146,
0.0067001246,
-0.016194675,
0.012724388,
-0.034468923,
0.0058358023,
0.02362915,
-0.015791759,
0.048064135,
0.009637522,
-0.009514047,
0.008896674,
-0.011002242,
0.014933934,
-0.007837391,
0.022368409,
0.011132215,
-0.018378228,
-0.0008521376,
0.014245076,
-0.016337646,
0.0011795079,
0.029321982,
-0.005247673,
0.00487075,
0.0033728078,
0.034936827,
0.037146375,
0.010969748,
-0.039199952,
-0.03293524,
-0.016766557,
0.002596217,
0.023824109,
-0.003658749,
0.0034280464,
-0.0012867359,
0.043593053,
-0.029192008,
0.026085645,
-0.01758539,
-0.009553039,
0.009078637,
-0.023031272,
-0.040109765,
-0.64383584,
-0.022056472,
0.0010219152,
-0.010976247,
0.0021201898,
0.03010182,
-0.00022928105,
-0.022472387,
0.0012940469,
0.028568136,
-0.01471298,
0.009618025,
-0.0067976047,
0.0042501274,
-0.031557523,
-0.0102224015,
-0.015622793,
-0.011697599,
0.036080595,
-0.026254611,
0.00011788986,
-0.0024093804,
-0.0035580196,
0.017156478,
-0.01334826,
0.013426244,
0.023876099,
-0.024201032,
-0.024447981,
0.012444945,
-0.015999716,
0.0035970116,
-0.006189979,
0.02430501,
0.04699835,
0.0029308985,
-0.009897469,
0.023109255,
0.005484874,
0.02605965,
-0.007070549,
-0.021328622,
0.007642431,
-0.007824394,
-0.0050884555,
0.030855667,
0.009293092,
-0.015414836,
-0.0039966796,
-0.017793348,
0.009273596,
0.015583801,
-0.017793348,
0.025968669,
-0.0028659117,
-0.007947869,
0.022537373,
-0.0024175039,
0.0051664393,
0.0007034806,
0.0009918589,
-0.019028094,
-0.017429423,
-0.031401552,
0.003678245,
-0.018846132,
-0.029971847,
-0.0027944264,
0.00686909,
0.013413247,
0.013192292,
0.012756881,
-0.006388189,
0.008298797,
0.035794653,
0.01588274,
0.02611164,
0.010111924,
-0.0151029,
0.01856019,
-0.018079288,
-0.022810318,
-0.01763738,
0.0024857398,
0.017039502,
-0.010488847,
0.0052541713,
0.024395993,
0.017598387,
-0.02474692,
-0.0064531756,
0.004029173,
-0.01213301,
-0.038602076,
-0.014440035,
0.018820137,
0.016298654,
0.013231284,
0.012659402,
0.0029601424,
-0.0029780136,
0.00019932627,
-0.012444945,
-0.029815879,
-0.0049519837,
0.028516147,
-0.015180884,
0.005777314,
0.062231224,
-0.028126227,
-0.013595209,
-0.005062461,
0.0012834865,
-0.010079431,
-0.0030088823,
-0.019599976,
0.013621204,
0.018248254,
-0.0007859324,
-0.020691752,
-0.013322265,
0.007837391,
0.009150121,
-0.0037854728,
0.031843465,
-0.0074539697,
-0.0037529797,
-0.022134457,
-0.041695442,
-0.016012713,
-0.011372666,
0.0030852417,
0.021640558,
0.005452381,
0.022589363,
0.027294397,
0.018456211,
-0.016194675,
-0.01529786,
-0.035768658,
-0.015609796,
-0.0076164366,
-0.014777967,
-0.01100874,
-0.023161246,
0.021159656,
-0.008110335,
0.011944548,
-0.013413247,
-0.009618025,
-0.0035677676,
-0.009923463,
0.003444293,
0.0025458524,
0.025734717,
-0.011359668,
-0.021146659,
-0.009078637,
0.0057415715,
0.0027846785,
-0.017039502,
0.0014695108,
-0.00034503854,
0.008415773,
-0.0044255913,
-0.0018586185,
0.0022956538,
0.0067001246,
0.0001879536,
-0.036964413,
0.0038504596,
-0.0017416425,
-0.026722515,
0.013855156,
-0.009780493,
0.008578239,
0.014920937,
-0.0070900447,
-0.007765906,
0.0009569286,
-0.012386457,
-0.009832482,
0.0030348771,
-0.015310857,
0.042007376,
0.0116911,
0.02605965,
0.0090006525,
-0.008058346,
0.011411658,
0.0085652415,
0.024123048,
-0.029841874,
0.017130483,
0.011054231,
-0.053133093,
0.0023265225,
-0.006206226,
-0.0075059594,
0.023122253,
0.04018775,
-0.011749588,
0.008838186,
-0.030075826,
0.018677166,
-0.008682217,
-0.0117040975,
-0.004672541,
0.0053516515,
0.0052346755,
0.015557806,
0.012626908,
-0.0009431189,
-0.020600772,
-0.000121139194,
0.00993646,
0.0072070207,
0.006124993,
-0.0007168841,
-0.008896674,
-0.016064702,
-0.008025853,
0.0068365964,
-0.0061119953,
-0.01198354,
0.027632328,
0.011743089,
0.017819341,
-0.017533401,
-0.04203337,
-0.0023460183,
0.011093223,
0.0074799648,
0.0043930984,
-0.0018326238,
0.0029438958,
0.0048675006,
-0.008981156,
0.019418014,
0.007863386,
0.020964697,
0.019327033,
-0.01067081,
-0.010586327,
0.020548781,
-0.0060535073,
0.015258868,
0.017312447,
-0.008350786,
0.00034036764,
0.011047732,
-0.016974516,
-0.033975028,
0.0025653483,
0.0042403797,
0.0071160393,
0.0070120604,
0.003765977,
0.016987514,
0.0041786423,
0.028906066,
-0.015258868,
-0.01729945,
-0.012997332,
0.005559609,
0.0042208834,
0.0023801364,
-0.017845336,
-0.023356205,
-0.0013752802,
-0.010436858,
-0.0052411743,
-0.0037107384,
-0.009442561,
0.022693342,
0.017754355,
0.010170412,
0.009871474,
0.01641563,
0.008045348,
-0.019301038,
-0.017715363,
0.006534409,
0.040603664,
-0.026241614,
0.0012656152,
0.013764175,
-0.0015263741,
-0.0025507263,
0.015115897,
-0.0017416425,
-0.003999929,
-0.002859413,
0.00082329975,
-0.017338442,
-0.0042403797,
0.0010698428,
-0.016480617,
0.007408479,
-0.004019425,
0.0037334836,
-0.008162324,
-0.017546399,
-0.016909529,
0.012035529,
0.015648788,
-0.0038699557,
-0.0063394485,
0.0044710822,
-0.027242407,
0.0056733354,
-0.014907939,
-0.018911118,
-0.028802088,
0.022134457,
-0.009683012,
0.009683012,
0.021393608,
0.031973436,
-0.0012014409,
-0.026124638,
-0.029451955,
-0.010215903,
-0.023161246,
0.047726203,
-0.022238435,
-0.007369487,
0.018989103,
-0.022576366,
-0.03186946,
-0.027684318,
-0.024175037,
0.020184856,
-0.014362052,
0.008591237,
-0.011080226,
0.0118795615,
0.015596799,
0.021211646,
0.02299228,
-0.019716952,
-0.03371508,
0.01763738,
0.013595209,
0.02011987,
-0.012496934,
0.022082467,
0.042241327,
0.032415345,
0.0062972074,
0.002786303,
0.0062582153,
0.013751177,
-0.003137231,
0.011190703,
0.022433395,
0.009897469,
0.013374255,
-0.030725693,
-0.007304501,
-0.0026774504,
-0.005026718,
0.014557011,
0.019483,
0.02201748,
0.026930472,
-0.0028139225,
0.006534409,
-0.0023687638,
-0.01583075,
0.016727567,
-0.0070575513,
-0.008032351,
-0.00085457455,
0.02494188,
-0.005445882,
0.00452957,
-0.025695726,
-0.00032554255,
-0.0065149125,
-0.002771681,
0.002484115,
-0.0014191462,
-0.0049032434,
-0.01427107,
-0.027840285,
0.015648788,
-0.0074994606,
-0.004614053,
-0.007869884,
-0.0019431012,
0.007863386,
-0.011054231,
-0.016350644,
0.005367898,
-0.014154094,
-0.023213236,
0.0054588793,
0.033819057,
0.011639111,
0.0170525,
-0.022186445,
0.010703303,
0.010839775,
-0.013985129,
-0.015141891,
-0.008337788,
-0.014219081,
0.006908082,
0.0054296353,
0.016571598,
-0.003980433,
0.009884471,
-0.010254895,
0.011639111,
-0.010241898,
0.0057610674,
0.0075124577,
-0.010566831,
0.018482206,
0.015427833,
0.025565753,
-0.0032948237,
-0.00905914,
-0.01627266,
-0.03303922,
0.0054621287,
-0.017988307,
0.022953289,
-0.02226443,
0.005104702,
-0.0023720132,
-0.014141098,
-0.01471298,
0.022316419,
-0.025968669,
0.021354616,
0.0050104717,
-0.0009504299,
0.0040551675,
0.03004983,
0.029945852,
0.018937113,
-0.026072647,
0.011054231,
-0.013582212,
0.037770245,
0.015466825,
-0.021692548,
0.020678755,
0.0170525,
-0.009091633,
-0.016649581,
-0.021172654,
0.00067098724,
0.045490663,
0.005202182,
-0.017455418,
0.0068041035,
-0.0118210735,
0.013504228,
0.0040259236,
-0.006901583,
0.0011583872,
-0.018521199,
0.0100469375,
0.020171858,
-0.015011919,
0.017429423,
-0.04374902,
0.017338442,
0.00021344057,
-0.006154237,
0.013881151,
-0.024395993,
0.0039284434,
-0.01763738,
-0.008701714,
-0.011307679,
-0.047284294,
-0.0034410437,
-0.027216414,
0.045126736,
0.026618537,
0.012204494,
0.0014110229,
0.0150769055,
0.027736306,
-0.006459674,
0.008987655,
0.005208681,
0.021640558,
-0.02644957,
0.006693626,
-0.0030949896,
-0.004636798,
0.019119075,
-0.00555311,
0.018586185,
0.009280095,
0.011418156,
-0.0029487696,
-0.010781287,
-0.010631817,
0.0076814233,
0.027346386,
-0.0076749246,
0.01213301,
-0.03857608,
-0.0077139167,
-0.0053321556,
-0.0024191283,
0.013062319,
-0.0067651113,
0.021068675,
-0.00803885,
0.0029731398,
-0.008890175,
0.02547477,
-0.0113271745,
-0.008201317,
-0.010852772,
-0.036834437,
0.0336111,
0.01159362,
-0.0041656448,
0.017377432,
-0.00044353397,
-0.018690163,
0.019132072,
0.00027355322,
-0.026085645,
-0.0043346104,
-0.01437505,
-0.015310857,
-0.0041721435,
-0.02674851,
-0.036158577,
-0.018339235,
-0.013062319,
-0.0048934957,
0.038082182,
-0.029451955,
-0.015999716,
0.04387899,
0.0025994664,
0.020093875,
-0.017819341,
0.043385096,
0.01622067,
-0.0068755886,
0.0014946932,
-0.025461772,
0.008363783,
-0.004389849,
0.027138429,
0.02937397,
-0.0075124577,
-0.013159798,
-0.016038708,
0.045958567,
0.002971515,
-0.023902094,
0.017013507,
0.019846926,
-0.01661059,
-0.01627266,
-0.017507406,
-0.012945343,
0.016285658,
-0.013582212,
-0.025903683,
-0.0021916751,
-0.012730886,
-0.0008135518,
0.032753278,
-0.0065311594,
0.021081673,
0.014673987,
-0.0032038423,
-0.007830893,
0.0027993005,
-0.015726771,
-0.019989897,
0.009981951,
0.023031272,
-0.01261391,
0.009234604,
0.017325444,
0.020145865,
-0.0041818917,
0.0011543256,
-0.008025853,
0.03618457,
0.0063102045,
-0.0133612575,
0.024344003,
0.0017578892,
0.0219265,
-0.003902449,
-0.008682217,
-0.024071058,
-0.024538962,
-0.015778761,
0.013296271,
0.027320392,
-0.035586696,
-0.002732689,
-0.018378228,
-0.0021656805,
-0.035690673,
0.011405159,
-0.007642431,
-0.03186946,
-0.020925704,
0.012685396,
-0.0028090484,
0.014621998,
-0.0030852417,
0.00959853,
-0.011073727,
0.025747715,
-0.027060445,
0.031739485,
0.03132357,
0.03644452,
-0.022420397,
0.012399455,
-0.004185141,
-0.025305806,
0.013491231,
-0.035820648,
-0.023408195,
-0.023980077,
-0.0058195554,
0.027684318,
0.014803961,
-0.036262557,
0.0142060835,
-0.010690305,
0.008669221,
0.0045230715,
-0.0022761577,
0.003395553,
-0.03862807,
-0.016597593,
0.012334468,
-0.035014812,
-0.0036749956,
-0.003512529,
0.0071745273,
-0.008415773,
-0.0054328847,
-0.00027964573,
-0.023460185,
0.004243629,
-0.005777314,
-0.006394687,
0.015947726,
-0.013751177,
-0.023148248,
0.015271865,
0.0003968248,
-0.013322265,
0.006060006,
-0.0072720074,
0.027268402,
0.008773199,
-0.007427975,
0.004857753,
0.014141098,
-0.04086361,
-0.018547192,
0.010118423,
-0.007544951,
0.02187451,
0.014881945,
0.016285658,
-0.0027603083,
0.0006945449,
-0.04983177,
0.015219876,
-0.00053248444,
0.026436573,
0.010092428,
0.0048057637,
0.026462568,
0.010807281,
0.02674851,
0.026072647,
-0.012360463,
0.006849594,
0.038186163,
-0.008207815,
0.0032233384,
0.0044938275,
-0.022693342,
-0.017065497,
0.029633917,
-0.013283273,
0.006254966,
0.028074237,
-0.0060762526,
-0.013881151,
0.026722515,
-0.0032428342,
0.0031404803,
-0.0062679634,
0.007661927,
-0.011873063,
0.01651961,
0.0025247317,
-0.008298797,
0.0016376638,
-0.017130483,
0.0064044353,
0.00774641,
-0.011580623,
-0.004263125,
-0.024136046,
0.033351153,
-0.0071615297,
0.0051826863,
0.022745332,
0.002683949,
0.039095975,
-0.005445882,
0.008370282,
0.01354322,
-0.015817752,
-0.022134457,
0.0049422355,
-0.009553039,
0.0005052713,
-0.0045328196,
0.007525455,
0.007817895,
-0.036990408,
0.008649725,
-0.013829161,
-0.002820421,
-0.0018180019,
0.018963108,
0.02061377,
-0.005972274,
0.00009829232,
-0.0092605995,
-0.017130483,
-0.031115612,
-0.0059885206,
-0.002654705,
-0.021328622,
0.010261393,
0.00051948713,
0.0073369937,
-0.00608925,
-0.0034897837,
0.006303706,
-0.020886712,
-0.011860065,
0.1792592,
-0.023395197,
-0.003717237,
0.01919706,
-0.0248509,
0.009799988,
-0.02245939,
0.018781144,
0.010956751,
0.025097849,
-0.014011124,
0.02747636,
-0.027502354,
-0.004607554,
0.01130118,
-0.031401552,
-0.019976899,
-0.015531812,
-0.009462058,
-0.008084341,
-0.029451955,
-0.003224963,
0.016896531,
-0.010014445,
0.040031783,
-0.0006677379,
-0.008207815,
0.0034800356,
0.03423497,
0.0052054315,
-0.01018341,
0.03025779,
-0.020626767,
0.0045133233,
0.018937113,
-0.00608925,
-0.004402846,
-0.002835043,
-0.021510584,
0.0019577232,
-0.0050819567,
0.0103653725,
-0.014596004,
-0.0014971301,
-0.0072850045,
0.013075316,
0.0020925705,
-0.011359668,
-0.0101639135,
-0.005202182,
-0.057864122,
0.017572394,
-0.0025750964,
0.020769736,
-0.0128088705,
-0.0043833503,
0.015284862,
0.01861218,
0.0123149725,
0.012418951,
-0.034858845,
0.02334321,
-0.010118423,
0.048454054,
0.011905557,
0.019638969,
-0.012600914,
0.012009535,
0.009566036,
0.009039644,
-0.0040909103,
0.00017779943,
-0.009442561,
0.0026969465,
-0.01836523,
-0.0033825557,
0.02089971,
0.013127306,
0.014115103,
0.02123764,
-0.005803309,
0.008929167,
-0.010456353,
0.018690163,
0.0094360635,
-0.028074237,
0.018417219,
0.008552245,
-0.02255037,
-0.009130626,
0.03316919,
-0.019431012,
-0.008409274,
-0.012094017,
0.015219876,
-0.014297065,
-0.0007554699,
-0.008155826,
-0.025032861,
0.010683807,
-0.0345989,
0.07798399,
0.024369998,
-0.0021932998,
-0.013179295,
-0.012977836,
-0.009065639,
0.024590952,
0.0027505604,
-0.015362847,
-0.008415773,
-0.0085067535,
0.0055173673,
-0.020132868,
0.007525455,
0.023941085,
0.00511445,
-0.03673046,
0.044398885,
-0.027736306,
-0.015310857,
0.0021153158,
0.006635138,
0.021016685,
-0.02299228,
0.00940357,
-0.016363641,
0.01135317,
0.014388046,
-0.03779624,
-0.01032638,
-0.0148429535,
-0.027138429,
-0.00964402,
-0.011223196,
0.0036522504,
0.023707133,
-0.00959853,
-0.007070549,
0.028490152,
-0.018885123,
-0.002781429,
-0.004272873,
0.014297065,
0.022940291,
-0.024538962,
0.017611384,
0.0051534423,
-0.029633917,
-0.012405953,
-0.01744242,
-0.009735001,
-0.009760996,
-0.0075124577,
0.0074019805,
-0.029581927,
-0.009475055,
-0.032467335,
0.0145830065,
0.023876099,
-0.022875303,
-0.0015824252,
0.011015239,
-0.038862024,
-0.005962526,
0.0013655322,
-0.16179079,
0.018820137,
0.021458596,
-0.005179437,
0.021276632,
0.012210993,
-0.02255037,
0.025487768,
-0.017351437,
0.019547988,
0.04213735,
-0.014440035,
-0.006849594,
-0.013237783,
-0.00798686,
-0.013335262,
0.00599177,
0.03010182,
0.017234461,
0.0046595437,
0.0233822,
-0.029737895,
-0.001982093,
-0.008266303,
0.021211646,
0.02469493,
-0.02226443,
-0.0020438305,
0.0016612215,
-0.014803961,
0.009994948,
0.0014987548,
0.025370792,
-0.013231284,
0.028386174,
0.0035840143,
-0.003059247,
-0.025084851,
-0.0014353929,
0.018911118,
0.02396708,
0.022147454,
-0.025162835,
0.014673987,
-0.0036847435,
0.014609002,
-0.019002099,
-0.024993869,
-0.0010600949,
-0.005757818,
0.015947726,
-0.009955957,
-0.016883533,
0.04520472,
0.019599976,
0.030361768,
-0.012016034,
0.01612969,
0.023876099,
0.0009967329,
-0.008987655,
0.010209404,
0.0024483723,
-0.001967471,
-0.009975452,
-0.019859923,
-0.0065246606,
-0.006358945,
-0.011743089,
0.010690305,
-0.029867869,
-0.03231137,
0.018378228,
-0.034520913,
0.016532606,
0.021939496,
-0.0034182982,
-0.008415773,
-0.020964697,
0.008162324,
0.0035677676,
-0.0035775157,
-0.025396787,
-0.028984051,
-0.019262046,
-0.014790963,
0.016636586,
0.0072265165,
0.0033728078,
0.009150121,
-0.00075628224,
-0.026410578,
0.019314036,
-0.009124127,
0.03254532,
0.022888301,
0.021848515,
-0.012607412,
0.00028695673,
0.009247602,
0.027684318,
0.011190703,
-0.031141607,
-0.006615642,
0.0053516515,
-0.0015548058,
0.0025750964,
0.009416567,
0.019885918,
0.0019837178,
-0.01149614,
-0.02270634,
0.015375844,
0.027788296,
-0.0016636585,
0.0077334126,
0.011769084,
-0.01719547,
-0.0067066234,
-0.027450366,
0.06176332,
0.004461334,
-0.009046143,
-0.0019723452,
0.008383279,
-0.01914507,
-0.12737386,
-0.021354616,
0.009475055,
0.01646762,
0.004107157,
-0.0077983993,
-0.005920285,
0.03322118,
-0.003054373,
0.022953289,
-0.028620126,
-0.0026969465,
-0.007122538,
-0.023980077,
0.029529938,
-0.007882882,
0.007005562,
-0.0017205218,
-0.014751972,
0.013868153,
0.009124127,
-0.01889812,
-0.00040697897,
0.009098132,
0.019911913,
0.0060177646,
-0.025448777,
-0.008701714,
0.022628356,
0.0057253246,
-0.017182473,
-0.008955162,
0.003843961,
-0.018885123,
0.008714711,
-0.016545603,
0.015479823,
-0.029919859,
0.026722515,
-0.023122253,
-0.013660196,
0.006579899,
0.044632837,
-0.013608207,
-0.0148429535,
-0.0032623303,
-0.037328336,
-0.0018797391,
-0.0031534776,
-0.0050722086,
-0.018300243,
-0.015128895,
-0.008786197,
-0.008844685,
0.04437289,
-0.0032964484,
-0.011912054,
0.0121395085,
-0.009423066,
-0.00080339756,
0.016428627,
0.0008659472,
-0.009267097,
0.014245076,
0.027398376,
-0.002718067,
-0.03673046,
-0.016506612,
0.034910835,
-0.02513684,
0.0036262556,
0.0014028995,
-0.01149614,
-0.006449926,
-0.011561126,
-0.0052541713,
0.008383279,
-0.026579544,
-0.017845336,
0.0032623303,
-0.016792553,
-0.03795221,
0.012340967,
-0.0005913786,
0.0050722086,
0.020080877,
-0.006498666,
0.010371871,
0.0023785117,
-0.024538962,
0.019599976,
0.033975028,
-0.0005016158,
-0.004022674,
0.0131013105,
-0.0077529084,
0.0043671033,
-0.013608207,
0.010300386,
0.010781287,
-0.0018618678,
0.002542603,
-0.037432317,
0.011658607,
0.0000063273146,
-0.0025978417,
0.031063624,
-0.008259805,
0.01680555,
-0.012210993,
-0.009773994,
0.018339235,
-0.021159656,
0.01651961,
-0.0013005455,
-0.0058520488,
-0.041149553,
-0.028776092,
0.03316919,
-0.01817027,
-0.0018732405,
0.026189623,
-0.0066026445,
-0.011678102,
0.0069535724,
-0.014868948,
-0.02703445,
-0.003590513,
0.002864287,
0.024344003,
-0.034182984,
-0.010358874,
0.012834866,
-0.029295987,
0.009241103,
-0.004760273,
-0.011743089,
-0.0082793,
-0.012542426,
0.034910835,
0.009994948,
0.02888007,
-0.040343717,
-0.029737895,
0.0021738037,
-0.034754865,
-0.0051274477,
-0.0047440263,
-0.04281321,
0.0000034238576,
-0.00798686,
-0.028230205,
0.033949032,
0.011925052,
-0.01110622,
-0.020431805,
0.00081233325,
0.019937906,
0.0072915033,
0.0015962349,
-0.029347975,
-0.042397298,
0.026007662,
0.036522504,
-0.007869884,
-0.004623801,
0.0069405753,
0.0033695584,
-0.021705544,
0.002913027,
0.0036360037,
-0.021081673,
-0.02031483,
-0.018872127,
0.014063113,
-0.008838186,
0.0010690306,
-0.0133027695,
0.006547406,
-0.007200522,
-0.02162756,
0.035118792,
0.025643736,
0.007876383,
-0.0043541063,
0.004636798,
0.023798116,
-0.00045531278,
0.0001557649,
0.0092021115,
-0.00915662,
-0.008623729,
-0.0065701515,
0.007817895,
0.009637522,
0.01232147,
0.024292013,
0.044840794,
-0.010612322,
-0.004899994,
-0.0040941597,
0.0041591465,
-0.020431805,
0.006563653,
0.005705829,
-0.033637095,
-0.0035222769,
0.023408195,
-0.017377432,
-0.030777682,
-0.024395993,
0.0122564845,
-0.014427039,
0.008831687,
0.011535132,
-0.015375844,
-0.007668426,
0.00608925,
-0.0044060955,
0.0103653725,
-0.019768942,
0.009657018,
0.00019292915,
0.0021153158,
-0.010144417,
0.019859923,
0.009039644,
0.0065734005,
0.016584596,
-0.012165503,
0.009566036,
0.007310999,
0.0014524518,
-0.023057267,
-0.004614053,
0.0019788437,
-0.012366962,
-0.025981667,
-0.0104238605,
0.018846132,
-0.0024532464,
0.065402575,
0.015765764,
0.00012377927,
0.015310857,
-0.02396708,
0.010527839,
-0.017247459,
0.013439241,
0.0006734243,
-0.039953798,
0.026176626,
-0.020912707,
0.03366309,
-0.038082182,
-0.0028659117,
0.024188034,
-0.0302058,
0.0049194903,
-0.007187525,
0.005484874,
0.012932345,
-0.03293524,
0.0071615297,
0.016051706,
-0.012737385,
-0.0022241685,
0.010534338,
-0.0034572904,
0.005855298,
-0.0005909724,
0.02552676,
-0.0103653725,
-0.04598456,
-0.008324791,
0.0007445034,
0.007005562,
-0.020912707,
-0.014349055,
-0.016818548,
0.033143196,
0.017962312,
0.037042398,
-0.026423575,
-0.033793062,
-0.02527981,
-0.024097053,
-0.03327317,
-0.0384721,
-0.026878482
] |
Calcium influx is crucial for T cell activation and differentiation. The detailed regulation of this process remains unclear. We report here that golli protein, an alternatively spliced product of the myelin basic protein gene, plays a critical role in regulating calcium influx in T cells. Golli-deficient T cells were hyperproliferative and showed enhanced calcium entry upon T cell receptor stimulation. We further found that golli regulates calcium influx in T cells through the inhibition of the store depletion-induced calcium influx. Mutation of the myristoylation site on golli disrupted its association with the plasma membrane and reversed its inhibitory action on Ca2+
|
[
-0.02520408,
-0.0011636347,
0.0033608752,
-0.048871,
-0.038667455,
0.023746429,
-0.033287406,
-0.0071292296,
-0.0068244482,
-0.024355993,
0.016126899,
-0.004359696,
-0.0051083975,
0.010190292,
-0.0057080216,
-0.0017889331,
0.039356526,
0.011813584,
-0.023998205,
0.031432215,
-0.013715154,
0.037845872,
0.004568405,
-0.021533454,
-0.00025570975,
-0.008315226,
0.004280188,
-0.047545865,
-0.011654567,
-0.014324715,
0.0069370847,
0.0025011934,
-0.014258459,
0.005327045,
0.012529157,
-0.02864943,
0.032015275,
-0.007672535,
0.014298213,
0.008911537,
0.031405713,
0.02472703,
-0.007195486,
-0.009733121,
0.01749179,
0.016603949,
-0.0019313851,
-0.0030362168,
-0.026568968,
0.015464332,
0.024581265,
-0.00033666726,
0.015663102,
-0.013198351,
-0.025429351,
-0.017240014,
0.028410906,
-0.0066157393,
-0.0011147703,
-0.011124513,
-0.005101772,
-0.0015719421,
-0.00050065276,
0.012522531,
0.010329432,
0.016736463,
-0.01089924,
0.013549511,
0.0025177577,
-0.0030461554,
0.026926754,
0.034957077,
-0.018154357,
0.009143435,
0.020764874,
-0.020221569,
-0.035434127,
-0.011051631,
-0.0072551174,
0.024037959,
0.020367334,
-0.019002445,
0.0063440865,
0.033896968,
-0.0006016944,
-0.0081760865,
0.0033956598,
0.012860441,
0.0005789186,
-0.013218228,
0.019121706,
0.007460513,
0.030239593,
0.030239593,
-0.0056715803,
-0.004747298,
-0.008726018,
0.031299703,
-0.015133048,
-0.027880853,
0.0037633851,
-0.010866112,
-0.0026883688,
-0.016034141,
-0.01641843,
-0.019240968,
-0.010177041,
-0.017836325,
0.024355993,
-0.0015048571,
-0.026105171,
0.026767738,
-0.0014046438,
-0.04235133,
0.012138242,
0.006075747,
0.042086307,
-0.024607768,
0.00079011207,
-0.011011876,
0.005148152,
-0.008779023,
0.024077713,
-0.010249924,
0.019452991,
0.02150695,
0.013330864,
0.0029964629,
-0.013403746,
0.00087127666,
0.000663396,
0.0051083975,
-0.008527247,
0.021917742,
-0.006688622,
-0.0091765635,
0.004121172,
-0.0058537866,
0.011184144,
-0.019108456,
-0.011290155,
0.037209805,
0.0027745026,
0.013224853,
0.004220557,
0.02130818,
0.023136867,
0.023627168,
-0.012197873,
0.019439738,
-0.008209215,
-0.021268426,
0.0043265675,
-0.004873186,
0.008659761,
0.024369244,
-0.018101351,
0.05051417,
-0.011780456,
-0.03781937,
0.007864679,
-0.019519247,
0.010336057,
0.0006894846,
0.016723212,
0.022885092,
0.0034055985,
0.0009425027,
0.016577447,
-0.01721351,
0.00044433452,
0.030372107,
-0.0283579,
0.021758726,
-0.038084395,
0.015278813,
-0.005310481,
0.020844383,
-0.008262221,
-0.005247537,
-0.02491255,
0.022116512,
0.015013786,
-0.017929085,
0.0005979674,
0.0069172075,
0.03498358,
-0.007831551,
-0.004687667,
-0.024037959,
-0.0018651283,
0.0035149222,
-0.016179906,
-0.014019934,
-0.6369132,
-0.031220194,
0.029895058,
-0.003332716,
-0.013317613,
0.052925915,
0.009998148,
-0.024408998,
-0.005303855,
0.02570763,
-0.011806958,
0.023574162,
-0.008832029,
-0.020009547,
-0.015371572,
-0.041715268,
-0.004545215,
-0.01427171,
0.017332774,
-0.0005192875,
-0.008991045,
-0.022447797,
-0.008633258,
0.028410906,
0.0023040795,
0.025151074,
0.011608188,
-0.017677309,
-0.01925422,
0.04293439,
-0.014033185,
0.02091064,
-0.008136332,
0.00962711,
0.054330558,
0.0031621049,
-0.0042238696,
0.012734553,
-0.006463349,
0.032121286,
-0.023348888,
-0.0029434573,
0.019704767,
-0.0074737645,
-0.006423595,
0.015596846,
-0.0073545026,
0.012608665,
0.005698083,
-0.008626632,
0.019267472,
-0.0011445859,
-0.028596425,
-0.010296304,
-0.0021781917,
0.0019396672,
0.013012831,
-0.01670996,
0.014536737,
0.011866589,
-0.016762964,
0.01769056,
-0.014284962,
-0.0064832256,
-0.0052309725,
0.0034188498,
-0.002219602,
0.0077454173,
0.010581207,
0.032015275,
0.0092892,
-0.0025127884,
-0.036017183,
0.01916146,
0.0069238334,
0.009945142,
0.0063805277,
0.010640839,
-0.0011164268,
0.009759624,
-0.012734553,
0.006400405,
-0.0030941917,
0.0066554933,
0.020261323,
0.030080577,
-0.03400298,
0.02756282,
-0.00083773414,
0.0033393416,
0.025482357,
0.0029782422,
-0.014629497,
-0.035831667,
-0.02854342,
0.015027038,
0.006665432,
0.007553273,
0.003803139,
-0.03000107,
0.0033542495,
0.016550943,
0.003344311,
0.003929027,
0.0052508498,
0.020460093,
-0.040310625,
0.0016274322,
0.029152982,
-0.033684947,
0.0021964123,
0.0046744156,
-0.002519414,
-0.011608188,
0.006416969,
-0.01103838,
0.015769113,
0.014960781,
-0.027218284,
0.0005524159,
0.016034141,
-0.024806539,
0.013026083,
0.0146825025,
0.009534351,
0.011985851,
0.0020440216,
-0.009680116,
-0.0022676382,
-0.005721273,
-0.0016738119,
-0.0048599346,
0.0371568,
-0.032624837,
0.033896968,
0.016988238,
0.025005309,
0.0072021117,
0.01739903,
-0.030796152,
-0.015411327,
-0.02599916,
-0.0028175695,
-0.019943291,
0.00009343241,
0.0036905026,
-0.0062413886,
-0.008765772,
0.016656954,
-0.004899689,
0.013231479,
0.0060028643,
0.00085471245,
-0.0048201806,
0.0027728463,
0.0027662206,
-0.02727129,
-0.0026585532,
0.016034141,
-0.028013365,
-0.008149584,
0.017253265,
-0.020460093,
0.022434546,
-0.004584969,
-0.018684411,
-0.0048433705,
0.010309555,
-0.017717063,
-0.034268007,
0.010488448,
-0.011946097,
-0.013900672,
0.027032766,
0.0072153634,
0.008447739,
0.003435414,
0.008739269,
-0.016789468,
-0.015596846,
-0.0012737865,
-0.022845337,
-0.0020539602,
-0.011813584,
0.03588467,
0.015172802,
0.032624837,
0.026794242,
-0.00014607549,
0.031432215,
-0.002918611,
0.0129532,
-0.027350798,
-0.00016222558,
-0.020446843,
-0.057404872,
0.018233865,
0.017558046,
0.00071143213,
0.014974032,
0.00071060396,
-0.017823074,
0.008361606,
-0.0009822567,
0.025773887,
-0.016948484,
-0.0074406364,
-0.022885092,
0.019545749,
0.0051945313,
0.0077255405,
0.0061420035,
0.006956962,
0.0062447013,
0.011734076,
-0.00006480741,
-0.015504086,
-0.0077056633,
0.0072087375,
-0.016259413,
-0.0010137287,
0.011681071,
0.024302987,
-0.010428817,
-0.018114604,
0.006645555,
-0.001409613,
0.019532498,
-0.0006977667,
-0.009077178,
-0.013019457,
0.0023305821,
0.007241866,
-0.00017288879,
-0.003597743,
-0.0039157756,
0.008162835,
-0.00270162,
0.03734232,
0.003743508,
0.020208318,
0.012867066,
-0.006436846,
0.010640839,
-0.011111262,
-0.031405713,
0.017717063,
0.0014021591,
-0.0072484915,
0.026542466,
-0.0046512256,
-0.0032879927,
-0.013728404,
-0.017160505,
0.0054198047,
0.0012770994,
0.02491255,
0.019280722,
0.02814588,
0.02187799,
0.013913924,
-0.0035447376,
0.016073894,
-0.014868021,
-0.008745895,
0.010958871,
-0.015305316,
-0.016895479,
-0.025389597,
-0.008089953,
-0.021533454,
-0.0071491064,
0.016378677,
-0.036388222,
-0.0052342857,
0.031432215,
0.009574104,
-0.002559168,
0.006045931,
-0.0017905894,
-0.028119378,
-0.05883602,
0.0036043688,
0.0011197396,
-0.016749714,
-0.0020804629,
-0.026529213,
0.0035745532,
0.0049526943,
0.008189338,
0.0016531067,
0.00060293666,
-0.0062612654,
-0.0015032006,
-0.016047392,
-0.02952402,
-0.0036706256,
0.0014501952,
0.02267307,
0.004707544,
-0.021851486,
0.00013675813,
-0.016166653,
0.011416043,
0.032889865,
0.020738373,
-0.02112266,
-0.0025889836,
-0.007824926,
-0.023004353,
0.015292064,
-0.0012075298,
0.007692412,
-0.031988773,
0.0076659094,
0.005032202,
0.038269915,
0.0016340578,
0.016829222,
0.003972094,
-0.021334684,
-0.042669367,
0.0030262785,
-0.027072519,
0.0061651934,
0.029205987,
0.003849519,
0.0110185025,
0.0026171429,
-0.016140152,
-0.017558046,
-0.0067449403,
0.019280722,
-0.01828687,
-0.00032693578,
0.009242821,
-0.007685786,
0.007043096,
0.008361606,
0.03646773,
0.011919594,
-0.008255594,
0.023083862,
-0.0023090488,
0.024382494,
0.003683877,
0.0037136925,
0.027403804,
0.022302032,
-0.0155703435,
-0.0019048824,
0.01905545,
-0.004522025,
-0.01074685,
0.011495551,
0.01456324,
0.0075333957,
-0.025455855,
-0.021162415,
-0.040602155,
-0.008911537,
0.04195379,
0.006340774,
0.0093554575,
0.038428932,
-0.0015959601,
-0.0057080216,
0.005217721,
-0.014629497,
-0.013377244,
0.0016183219,
0.020393837,
0.02032758,
-0.023150118,
0.018644657,
-0.0034718553,
-0.0021864737,
-0.015676353,
0.0093554575,
-0.004873186,
0.0042238696,
-0.013118843,
0.006645555,
0.0000726754,
-0.008944665,
-0.015451081,
-0.013953677,
-0.011594936,
-0.006771443,
-0.012734553,
0.004522025,
-0.009613859,
-0.0046379743,
-0.027297793,
0.02785435,
-0.03694478,
-0.04327893,
-0.007274994,
0.015252311,
0.007977316,
0.0148282675,
0.0024564702,
0.00221132,
0.025548615,
-0.009189815,
-0.015702857,
0.0021533454,
-0.03800489,
0.007115978,
0.017518293,
-0.003475168,
-0.015954632,
0.01476201,
0.00037103795,
-0.007652658,
-0.0051713414,
0.00031575497,
-0.02258031,
-0.0022328536,
0.012409895,
0.02472703,
0.009620484,
0.0017541482,
-0.0073081227,
-0.010620962,
-0.036812264,
-0.02629069,
-0.017942335,
-0.023335638,
-0.020221569,
0.008567002,
0.016789468,
0.011813584,
-0.013966929,
-0.018445887,
-0.004180803,
0.0032018588,
-0.018220615,
-0.0041410485,
0.023044107,
0.00046503978,
0.023759682,
0.003620933,
-0.020248072,
0.014205453,
-0.028967464,
0.011893092,
-0.015278813,
-0.01094562,
0.012780933,
0.008991045,
-0.017160505,
0.0046512256,
-0.019903537,
0.007752043,
0.0059564845,
-0.00034287883,
-0.034215,
-0.013337489,
0.0045783436,
-0.018406132,
-0.0008306944,
0.0031621049,
-0.022898342,
-0.007261743,
0.015848622,
0.00012899366,
-0.018631406,
0.016153403,
-0.032810356,
-0.0051713414,
-0.004071479,
0.022593562,
-0.0021003399,
0.0043696347,
0.002733092,
-0.04357046,
-0.020460093,
-0.027350798,
-0.025561865,
-0.010018025,
-0.014894524,
0.039568547,
0.032969374,
0.051335752,
0.014086192,
0.022964599,
-0.008427862,
0.0036308714,
0.011846712,
-0.0036673127,
0.010938995,
-0.025840145,
-0.00065262924,
0.0020407087,
0.0017226762,
0.05130925,
-0.023799434,
0.008295349,
0.023759682,
-0.021096159,
-0.011217273,
-0.0022875152,
-0.010342683,
-0.03479806,
0.020738373,
-0.009421714,
-0.00048988604,
-0.015888376,
-0.0022096636,
0.037183303,
0.0054463074,
0.010819732,
0.0022593562,
0.015504086,
-0.026940007,
0.02258031,
-0.009998148,
0.009328955,
-0.0034221627,
-0.039727565,
0.0042172438,
0.008606755,
0.012502654,
-0.016749714,
0.013271233,
0.011787081,
0.0049030017,
-0.006681996,
0.01036256,
-0.0148282675,
-0.006685309,
-0.016405178,
-0.008971168,
-0.026767738,
-0.019731268,
-0.015027038,
-0.023494653,
0.0064500975,
0.00723524,
-0.028967464,
0.012668296,
-0.0026419892,
-0.012946575,
0.038640954,
-0.0019396672,
0.026025662,
-0.027721837,
0.020168563,
0.011349786,
0.015451081,
-0.007911059,
0.005429743,
0.010077656,
0.0016075551,
0.041582756,
0.016034141,
-0.017717063,
-0.009269323,
-0.011707573,
0.007400882,
-0.010375812,
-0.018843427,
0.005406553,
0.015875123,
0.013754907,
-0.019678263,
-0.0029865243,
-0.037077293,
-0.0045518405,
0.006045931,
0.0020655552,
0.005280665,
-0.025482357,
-0.020102307,
0.02883495,
-0.0064269076,
0.015649851,
-0.012403269,
-0.021745475,
0.0011470704,
-0.010057779,
0.0026270812,
0.0009996492,
-0.005691457,
0.047201328,
-0.01060771,
0.0019645134,
0.002733092,
0.010170416,
0.019081952,
-0.013363992,
0.009660238,
0.040151607,
-0.0020589293,
0.0003521962,
0.023998205,
-0.008712767,
0.002025801,
-0.033260904,
-0.0049891355,
-0.0053634862,
-0.033790957,
0.019559002,
0.01750504,
0.0065594213,
-0.021520201,
0.018737417,
-0.011051631,
-0.0117605785,
-0.031750247,
-0.00020405017,
0.0026751175,
-0.032200795,
-0.011349786,
-0.027138777,
0.012727927,
0.012992954,
-0.001480839,
0.0058570993,
-0.0180881,
0.02854342,
-0.033472925,
0.020367334,
0.016762964,
0.011257026,
-0.017929085,
-0.008229092,
-0.0053568603,
-0.02454151,
0.019903537,
-0.014205453,
-0.040443137,
-0.01447048,
-0.02121542,
0.027430307,
0.0041311104,
-0.00596311,
0.02207676,
0.009666864,
0.017942335,
0.028278394,
0.00061784446,
0.009315703,
-0.012356889,
-0.01885668,
-0.018300122,
-0.010978748,
-0.019532498,
0.0077189147,
0.005611949,
-0.0020473346,
-0.0017707124,
-0.0016555913,
-0.030425113,
-0.0039224015,
0.0050984593,
0.0029484266,
-0.007904434,
-0.005452933,
-0.0072021117,
-0.002128499,
0.008547124,
-0.016550943,
-0.013112216,
-0.015702857,
-0.008083327,
0.01720026,
-0.021175666,
-0.016961735,
-0.0014824955,
-0.032412816,
-0.025535362,
-0.012032231,
-0.030239593,
0.021480449,
0.0046446,
-0.012257504,
-0.01260204,
0.02178523,
-0.05199832,
-0.025296839,
0.0031919202,
0.0024134032,
-0.011402791,
0.020393837,
-0.014152448,
0.017531544,
-0.019824028,
0.02081788,
0.0081760865,
0.009024173,
0.010157164,
-0.0062645786,
0.020195067,
0.0047969907,
-0.011912969,
-0.019704767,
0.0244355,
-0.013622394,
0.008341729,
0.028914459,
-0.024594516,
0.01275443,
-0.013635645,
0.015040289,
0.010044527,
0.010992,
0.023348888,
-0.032677844,
0.004035038,
-0.010832983,
-0.010488448,
-0.011522054,
0.006950336,
-0.010110784,
0.0043464447,
-0.0046512256,
0.022209272,
-0.02540285,
-0.003095848,
-0.0043729474,
0.008871783,
0.031882763,
-0.016299168,
0.008944665,
0.017558046,
0.00009871225,
-0.0057411497,
0.007261743,
-0.010011399,
0.0020986835,
-0.006151942,
-0.0015686293,
-0.0112437755,
-0.0039224015,
0.007712289,
-0.027324295,
-0.009269323,
-0.018883182,
0.024965554,
-0.032571834,
0.018406132,
-0.00326149,
-0.031935766,
0.010382437,
-0.012920072,
0.0071491064,
-0.031750247,
-0.0017276455,
-0.02432949,
-0.0021550017,
-0.021440694,
0.01769056,
0.013582639,
0.0027827846,
-0.008262221,
0.0032366437,
-0.02385244,
-0.008944665,
0.19283372,
-0.023534408,
-0.0175978,
0.009494596,
-0.013204976,
-0.011634691,
0.019240968,
-0.012476152,
-0.0035281735,
0.018048346,
0.01788933,
0.019187963,
0.0027662206,
-0.011157641,
-0.0018634719,
0.008759147,
-0.026940007,
-0.015133048,
-0.019718017,
-0.013847667,
0.022315282,
-0.0037700108,
0.0014386004,
-0.01266167,
0.04258986,
0.015477584,
-0.011349786,
0.006585924,
0.0021036528,
0.02258031,
-0.02472703,
0.014231956,
-0.016140152,
-0.008010444,
0.003929027,
0.026343696,
-0.02207676,
-0.015424578,
0.009262698,
-0.017359275,
-0.0033029004,
-0.0013441844,
-0.025681127,
0.0009996492,
-0.007241866,
0.01847239,
0.0071491064,
-0.022765828,
-0.016431682,
0.022143016,
-0.04174177,
0.002602235,
0.0011835117,
0.014496983,
0.005409866,
-0.005366799,
0.0033227776,
0.016829222,
-0.000014428966,
0.03832292,
-0.005737837,
0.0141656995,
-0.021771977,
0.032783855,
-0.016590698,
-0.006168506,
-0.025084816,
-0.009806003,
-0.0056715803,
-0.025667876,
0.008156209,
0.009799378,
-0.015278813,
-0.016444933,
-0.027827848,
-0.006334148,
0.033896968,
0.02491255,
0.00042859855,
0.014218705,
0.00042155877,
0.029152982,
-0.022461047,
0.0003285922,
0.00875252,
-0.01799534,
0.004568405,
-0.0054562455,
-0.024422249,
-0.016776217,
0.009302451,
-0.016391927,
-0.0019992983,
0.014417475,
0.00039112204,
-0.016285917,
-0.006393779,
0.00028656056,
-0.007871306,
-0.016974987,
-0.040496144,
0.07007317,
0.019863782,
0.022898342,
-0.0071557323,
-0.0022046943,
-0.013953677,
0.00022258137,
-0.009401837,
-0.0041708644,
0.0046644774,
-0.018300122,
0.013218228,
-0.008162835,
-0.027218284,
-0.013185099,
0.019413237,
-0.0071557323,
0.05122974,
0.002262669,
0.0020870885,
-0.009063927,
-0.010150539,
0.032492325,
-0.0004240434,
-0.00046503978,
-0.030054076,
0.0175978,
-0.01847239,
-0.02981555,
-0.010336057,
-0.0012812405,
0.013151971,
0.011793707,
-0.0013988463,
-0.01045532,
0.02512457,
-0.010243298,
-0.005386676,
0.0015512368,
-0.01828687,
-0.009415088,
0.018432636,
0.0007437323,
-0.0010957215,
-0.0058471607,
0.0041476744,
0.021082908,
-0.010044527,
-0.029974567,
-0.0030494682,
-0.024462003,
-0.012542408,
-0.005906792,
0.035831667,
-0.037395325,
0.0021781917,
-0.026436456,
0.00522766,
0.0049063144,
0.00036482638,
-0.009746372,
0.025058314,
-0.015941381,
-0.012257504,
-0.003170387,
-0.16633102,
0.014284962,
0.0075400216,
-0.008726018,
0.016007638,
0.016312419,
0.0081760865,
-0.005307168,
-0.011840086,
0.005085208,
0.030531123,
0.009859009,
-0.03821691,
-0.01417895,
0.016007638,
-0.0019893597,
-0.026515963,
0.030955167,
0.011442546,
0.024766784,
0.025084816,
-0.032810356,
0.014443978,
-0.023229627,
0.0059564845,
0.019863782,
0.013224853,
-0.0050918334,
-0.01916146,
0.0003037459,
-0.029921561,
0.010952245,
0.023733178,
0.009786126,
0.039356526,
-0.014934278,
-0.0070298444,
-0.010846235,
0.014404223,
0.040151607,
0.037898876,
0.006436846,
0.007937562,
0.012529157,
-0.014510235,
0.03628221,
0.00013924277,
-0.012767681,
0.033658445,
-0.010084282,
0.039727565,
-0.017558046,
-0.0029765859,
0.033313908,
0.02169247,
0.029842053,
0.010289677,
0.017465286,
-0.002973273,
0.006701873,
0.002222915,
-0.004724108,
0.0244355,
-0.003498358,
0.014033185,
-0.03683877,
0.002693338,
0.008931414,
-0.016034141,
0.006539544,
-0.027907355,
-0.018419385,
0.021824982,
-0.008381482,
0.020579355,
0.009249446,
-0.0078050485,
-0.003889273,
-0.0122773815,
-0.0065064155,
-0.016789468,
0.009156687,
-0.02549561,
-0.017160505,
-0.03312839,
0.012568911,
0.009766249,
0.03312839,
0.01876392,
0.011482299,
-0.006145316,
-0.022063507,
-0.007361128,
-0.01583537,
0.038985487,
0.026966508,
-0.011919594,
-0.010614336,
0.00029856962,
0.013032708,
0.023242878,
-0.0067581916,
-0.018432636,
-0.009474719,
0.007612904,
-0.0005789186,
-0.0011677757,
0.010382437,
0.026171427,
-0.011740701,
0.0072948714,
0.01114439,
-0.0015545497,
0.010832983,
-0.0064070304,
0.008070076,
-0.003044499,
-0.015649851,
0.008745895,
-0.012780933,
0.054860614,
-0.007712289,
0.007241866,
0.004869873,
-0.021135913,
-0.010687218,
-0.13463378,
-0.022063507,
0.0033989728,
0.018445887,
-0.013118843,
0.005923356,
-0.006440159,
0.017942335,
-0.020155312,
0.007851428,
-0.0249258,
0.013125468,
-0.017717063,
-0.016484687,
-0.0016671862,
-0.000060821654,
0.0075400216,
0.009077178,
-0.019704767,
0.018035095,
0.00026916817,
-0.019837279,
-0.005552318,
-0.0020009547,
-0.0040482893,
0.0067350017,
-0.037686855,
0.024488505,
0.008779023,
0.015808867,
0.009746372,
-0.001409613,
0.0254161,
-0.006347399,
-0.013224853,
-0.0027082458,
0.0016208064,
-0.011912969,
0.032969374,
-0.0013706872,
0.0008480868,
0.019333728,
0.0049030017,
0.017120752,
0.0010841265,
-0.006393779,
-0.015822118,
0.007964064,
0.018538646,
-0.02178523,
-0.019108456,
-0.02658222,
-0.03400298,
-0.013728404,
0.008639884,
0.011747327,
-0.0025442604,
0.036971282,
-0.013112216,
0.008626632,
0.010475197,
0.018101351,
0.012992954,
-0.009302451,
0.039224014,
-0.010256549,
-0.0041079205,
-0.044498052,
0.027986864,
-0.025243832,
-0.012641793,
-0.012177996,
-0.013357366,
-0.009613859,
-0.023560911,
0.032598335,
-0.0069172075,
-0.001662217,
0.011833461,
-0.038614452,
-0.020764874,
-0.011310033,
0.020645613,
0.0005872007,
0.040628657,
0.01417895,
0.0048599346,
0.00777192,
0.014059689,
-0.016749714,
-0.01758455,
0.03644123,
0.019214466,
-0.016087146,
-0.0064766,
0.031246698,
-0.0036308714,
0.000639792,
0.012012354,
0.0042669363,
-0.025283586,
-0.03508959,
-0.063765526,
0.021082908,
0.013966929,
0.0059366073,
0.018233865,
-0.014788513,
-0.0049825097,
-0.015769113,
0.007791797,
-0.0024415622,
0.008315226,
0.007506893,
-0.00041389783,
0.0028970777,
-0.02228878,
-0.011230524,
0.038826473,
-0.02158646,
0.007447262,
0.03665325,
0.000068637884,
-0.0073478767,
0.014642748,
0.010157164,
0.0035049836,
0.0037203182,
0.004339819,
0.031617735,
-0.014483732,
-0.02140094,
0.004975884,
-0.027880853,
0.0007408336,
-0.00544962,
0.0037302566,
-0.02648946,
-0.006168506,
0.02219602,
0.025588367,
0.019267472,
-0.001472557,
-0.026264187,
0.011263653,
-0.0020125497,
0.00023065641,
-0.0044491426,
-0.043649964,
0.011184144,
0.0069635874,
-0.013191724,
0.014218705,
0.007142481,
0.008169461,
-0.03334041,
0.0021152478,
0.01837963,
-0.0047207954,
-0.001737584,
0.0030627197,
-0.0036010558,
-0.000722613,
0.02112266,
0.007241866,
-0.006903956,
0.010534828,
0.0058869147,
-0.04966608,
0.008162835,
0.0058537866,
-0.035222102,
-0.021082908,
0.029471016,
0.02464752,
0.0042238696,
-0.002222915,
0.016365424,
-0.016246162,
-0.012827313,
-0.008865157,
0.0065759853,
0.020672115,
0.000073348325,
-0.014589743,
0.013112216,
0.035911173,
0.023348888,
0.007778546,
0.028490415,
-0.010077656,
0.006857577,
-0.0039025242,
0.028490415,
0.008613382,
0.017041244,
0.043623462,
0.040390134,
-0.016643703,
0.01632567,
0.024316238,
0.03469205,
-0.00022051085,
0.0011578372,
0.005025577,
-0.02083113,
-0.0053303577,
0.017080998,
-0.042854883,
-0.049507067,
-0.0066356165,
-0.0073545026,
0.0180881,
-0.0035082963,
0.007964064,
0.00008328684,
-0.0069370847,
0.015146299,
0.028622929,
-0.0022692946,
-0.0025094755,
0.015822118,
0.0014054719,
0.010296304,
-0.01701474,
-0.01779657,
0.0093223285,
0.0005549005,
0.020367334,
-0.008441114,
0.015411327,
-0.0122442525,
0.0019280723,
0.011555182,
-0.03760735,
-0.013887421,
0.010587833,
0.00040851446,
0.016272664,
0.024316238,
-0.01770381,
0.09164637,
-0.01119077,
-0.001840282,
-0.016762964,
0.014112694,
0.015702857,
-0.008639884,
0.027112273,
-0.032889865,
-0.03691828,
0.025747385,
0.0008571971,
0.013476629,
-0.040681664,
-0.010263175,
0.031803254,
-0.0074406364,
0.007241866,
0.013754907,
-0.017240014,
0.007752043,
-0.025151074,
-0.004035038,
0.004840058,
-0.02190449,
-0.011257026,
0.022037005,
0.005595385,
-0.024355993,
-0.023401894,
0.0015959601,
-0.0070165927,
-0.043729473,
-0.019148208,
-0.001725989,
-0.023401894,
-0.030266097,
-0.008971168,
-0.016736463,
0.011078133,
-0.020990148,
0.013496506,
-0.012443023,
-0.019863782,
-0.0024134032,
-0.0016572477,
-0.016391927,
0.001208358,
-0.006340774
] |
Renal carcinomas have been shown to contain a population of cancer stem cells (CSCs) that present self-renewing capacity and support tumor growth and metastasis. CSCs were shown to secrete large amount of extracellular vesicles (EVs) that can transfer several molecules (proteins, lipids and nucleic acids) and induce epigenetic changes in target cells. Mesenchymal Stromal Cells (MSCs) are susceptible to tumor signalling and can be recruited to tumor regions. The precise role of MSCs in tumor development is still under debate since both pro- and anti-tumorigenic effects
|
[
-0.008145606,
-0.00928205,
0.0028985876,
-0.014018325,
-0.018130543,
-0.004351987,
-0.020758158,
-0.000009936952,
-0.026420668,
0.009019288,
0.020745018,
0.013558493,
-0.010523598,
-0.0024502508,
-0.008815648,
-0.00429615,
0.032713804,
-0.012382635,
-0.0065821754,
0.0059581166,
-0.021047195,
-0.0034947277,
-0.0033863387,
-0.005971255,
0.010385647,
0.033002842,
0.014622676,
-0.023976985,
0.010392217,
-0.0372333,
0.0034126148,
0.011357865,
-0.020285187,
-0.013000124,
-0.022045689,
0.017105773,
0.010720668,
-0.015266442,
0.016251797,
-0.0148722995,
0.01378184,
-0.0039545605,
-0.012586275,
-0.012514016,
-0.008106192,
0.0080930535,
0.004062949,
-0.004407824,
-0.006595313,
0.03137372,
0.020797571,
0.00344546,
-0.015082509,
0.00044176774,
-0.023753637,
-0.0034158994,
-0.0077646016,
0.030874474,
0.025487864,
-0.0088090785,
0.020836985,
0.009682761,
-0.030795645,
0.0018212656,
-0.0059614014,
0.013479664,
-0.010109748,
0.0042403135,
0.0001738742,
0.008828786,
0.031268615,
0.01009661,
-0.024712717,
-0.013427112,
-0.001152866,
-0.01895824,
-0.021677822,
0.0065329075,
-0.009906108,
0.000867934,
-0.0027392884,
-0.026184183,
-0.0075346855,
0.031767864,
0.0027655647,
0.02987598,
-0.016383179,
-0.015029957,
0.010720668,
-0.006086213,
0.01378184,
0.026079077,
-0.016816735,
-0.0044045392,
-0.009814141,
0.007804016,
0.011883388,
0.029665772,
0.009978367,
-0.043381922,
-0.0019329392,
0.034842175,
-0.009899539,
-0.026079077,
-0.04687665,
-0.0026440374,
0.016186107,
0.0025947697,
0.031321168,
0.010313388,
-0.017026944,
0.03439548,
-0.0010157373,
-0.034185268,
0.016659077,
0.010622133,
0.03452686,
0.018879412,
-0.016343765,
-0.007087991,
0.007061715,
0.015910208,
0.021638408,
-0.027668783,
0.047165688,
0.011922803,
-0.0038396022,
0.00034323218,
-0.006358828,
0.005935125,
-0.0011224842,
-0.013584768,
-0.0073507526,
0.022190208,
-0.017499914,
-0.005258514,
-0.017499914,
-0.0101294555,
-0.020915814,
-0.02653891,
-0.006884351,
0.023057321,
-0.020153806,
0.01998301,
-0.024844099,
-0.013611045,
0.01357163,
0.0035866944,
0.016120417,
0.012763639,
0.020232635,
-0.022255898,
0.011508953,
-0.023438325,
-0.012382635,
-0.011292174,
0.010865187,
0.010405355,
-0.016803596,
-0.010582719,
-0.0004889827,
0.004923493,
0.023346357,
0.008493765,
0.0071930955,
0.020140668,
0.011843974,
0.000177364,
-0.0059614014,
-0.009610501,
0.002919937,
0.030296398,
-0.016317489,
0.014412467,
-0.025671797,
0.0043224264,
-0.019772802,
0.013965772,
-0.04816418,
-0.02790527,
0.0040563806,
0.032240834,
0.021152299,
0.0046016104,
-0.005833305,
-0.016698493,
0.041227277,
-0.01480661,
-0.0015420815,
-0.020574223,
-0.015923345,
0.023057321,
-0.0066544344,
-0.013886944,
-0.6365134,
-0.04763866,
0.019076483,
-0.000045008168,
0.020074977,
0.034815896,
0.009728744,
-0.009925815,
-0.043697234,
0.0014648953,
-0.023162425,
-0.003964414,
-0.0019904182,
0.003236893,
-0.009544811,
-0.030637989,
-0.020731881,
-0.012382635,
0.03200435,
-0.0034947277,
-0.023083596,
0.017026944,
-0.003560418,
0.013663597,
0.00041343877,
0.011167363,
0.00784343,
-0.002571778,
0.011088534,
0.03505238,
-0.029008867,
0.014412467,
-0.033712298,
0.004023535,
0.04577305,
0.025093721,
0.0009968514,
0.031216064,
-0.010267405,
0.04204184,
-0.009748451,
-0.0012218409,
0.015043095,
0.0050844345,
-0.024673304,
0.009393723,
0.011449832,
-0.005035167,
-0.019312968,
-0.005327489,
0.012934434,
0.012185564,
-0.02803665,
-0.0020495395,
0.025737487,
0.00073573214,
0.019785939,
-0.018656066,
0.003875732,
0.003015188,
0.015726274,
0.034185268,
-0.0077711707,
-0.010582719,
0.019877907,
0.019470626,
-0.03752234,
0.00003317877,
0.007889413,
-0.014267948,
0.008375523,
0.029140249,
-0.00900615,
0.0064902087,
0.016593387,
0.05189539,
-0.0064278026,
-0.004930062,
-0.0023484307,
-0.0005756119,
0.00798138,
-0.004066234,
-0.026276149,
0.0072062337,
0.0067661083,
0.006936903,
-0.011081966,
-0.003609686,
0.0052289534,
0.031689037,
0.0065657524,
0.008894476,
-0.0074361498,
-0.054549284,
-0.0023205124,
0.025435312,
-0.014662091,
0.024778407,
0.0017588597,
-0.02995481,
-0.019588869,
-0.02183548,
0.0055836816,
-0.007114267,
0.015121924,
-0.0040925103,
-0.054969702,
-0.008539748,
0.026644014,
-0.029718325,
0.024121504,
0.0071930955,
0.009058702,
-0.018853137,
-0.018406441,
-0.02530393,
0.00024284908,
0.031268615,
0.0010994925,
-0.034185268,
0.0005366082,
-0.00045080017,
-0.00402682,
0.0061354805,
0.021598995,
0.0026588177,
0.00016135197,
-0.020850124,
0.00018968094,
-0.023911295,
-0.0006129733,
-0.041463763,
0.008835355,
-0.020074977,
0.020902677,
-0.028430793,
-0.002368138,
-0.0008983158,
-0.010168869,
-0.027248366,
-0.03807414,
-0.026171044,
0.020416567,
-0.018787446,
-0.012842467,
0.007987949,
-0.004059665,
-0.0071930955,
0.01146297,
-0.01991732,
-0.011436693,
-0.00586615,
0.00024079626,
0.0026637446,
0.019194726,
-0.0033732005,
0.00064130226,
-0.0058760038,
0.013900083,
-0.022347864,
-0.007961673,
0.01023456,
-0.0036031168,
0.006838368,
-0.0059252717,
-0.014924852,
-0.015200752,
0.005636234,
0.0016553974,
-0.029797152,
-0.018327614,
-0.018669203,
-0.0035571335,
0.02756368,
-0.008257279,
-0.0031679182,
-0.02613163,
-0.0016258367,
-0.0029872695,
-0.001709592,
0.01807799,
-0.029140249,
-0.00020887484,
-0.0035111504,
0.027984098,
0.03662895,
0.041726522,
0.004020251,
0.012842467,
0.022689454,
-0.04078058,
0.023530291,
-0.01214615,
0.01617297,
0.029376734,
-0.036812883,
0.0073573217,
0.017250292,
0.018169956,
0.013118367,
0.003711506,
-0.007797447,
0.019391797,
-0.0059318403,
0.026565187,
-0.010247698,
-0.015161337,
-0.006181464,
0.016895564,
0.01903707,
0.014438744,
0.022111379,
-0.028010374,
-0.000026211997,
-0.0068186605,
0.008953597,
0.0030628135,
-0.027668783,
-0.0056329495,
-0.008198158,
-0.012507447,
-0.01418912,
0.022006275,
-0.019693973,
-0.0027179392,
0.0062405854,
0.0011405491,
0.029113973,
-0.015568618,
-0.0009147384,
-0.0017933472,
0.03915146,
0.014754057,
0.0060500833,
0.01555548,
0.003984121,
0.014701505,
-0.016869288,
0.02906142,
-0.003491443,
0.0056592254,
0.003345282,
-0.002913368,
0.016829873,
-0.0008297515,
-0.018235646,
0.026525771,
0.015857656,
-0.008743389,
0.014780333,
-0.011180501,
0.016054727,
-0.01357163,
0.015739413,
-0.0021152298,
-0.01807799,
0.0077251876,
0.022886526,
0.052552298,
0.00453592,
0.01698753,
-0.00054317724,
0.0031432842,
-0.025001755,
0.0050253132,
0.011062259,
0.03000736,
0.007554393,
0.0025028032,
0.01412343,
-0.009222928,
0.0036688072,
0.0069763176,
-0.042199492,
-0.0022285457,
0.0132957315,
0.021953722,
0.016593387,
0.0018229078,
0.02053481,
0.008355815,
-0.016843012,
0.030611712,
0.00019039944,
-0.008079915,
-0.012842467,
-0.030690541,
0.0050318823,
-0.008467489,
0.007948535,
0.018603513,
0.029271629,
-0.01719774,
-0.008559455,
-0.009518535,
-0.0026062655,
-0.0073441835,
-0.015450375,
0.04558912,
0.009853556,
-0.004631171,
-0.010576149,
-0.0022597488,
0.0035637026,
0.029744599,
0.010536736,
-0.006904058,
-0.01022799,
-0.01064184,
-0.028351964,
-0.011042551,
-0.010825773,
-0.011009706,
-0.017368535,
0.00791569,
-0.0018376881,
0.035446525,
-0.009636777,
0.039256565,
0.021454476,
-0.0077054803,
-0.029350458,
-0.0055771125,
-0.022111379,
0.024607614,
0.027800165,
-0.0129935555,
0.015161337,
0.013466526,
-0.0066347276,
-0.009873263,
-0.025185687,
0.005442447,
-0.018577237,
-0.0023812759,
-0.002964278,
0.011134518,
0.00433228,
0.0016102352,
0.02224276,
-0.011246191,
0.0033305017,
-0.004200899,
-0.024975479,
-0.0014501149,
0.004223891,
0.046272296,
0.047165688,
0.014412467,
-0.0031810561,
0.0041582007,
0.019667696,
-0.007219372,
-0.009531673,
-0.003268096,
0.026985604,
-0.0013573273,
0.012402342,
0.0047986815,
-0.03615598,
0.0059614014,
0.02668343,
0.0028903764,
0.016488284,
0.016264936,
0.019312968,
0.024371129,
0.00675297,
0.012599413,
-0.015660584,
0.0063456898,
0.0040892255,
0.012789915,
-0.011160794,
0.019299831,
-0.0326087,
-0.0012497593,
-0.018393304,
0.0171846,
0.013315438,
0.00069878134,
-0.014070878,
-0.01357163,
-0.0058694347,
0.0017325835,
0.0009442991,
0.0017621442,
-0.015200752,
-0.000023132761,
0.009222928,
-0.006217594,
-0.018472133,
-0.027957821,
0.010464476,
0.023477739,
-0.015371547,
-0.028220583,
0.010168869,
0.0016685354,
0.020850124,
0.017920334,
-0.00010500195,
-0.009833848,
0.02803665,
0.01752619,
-0.011305313,
-0.02019322,
-0.043881167,
-0.017355395,
-0.008933891,
-0.0052026776,
-0.0012251254,
-0.018301338,
0.00084412127,
0.021204852,
-0.0065394766,
0.0076792045,
-0.0088682,
-0.014964267,
-0.0032516734,
0.014898576,
-0.010556443,
-0.0038396022,
0.009150669,
-0.0009894612,
-0.039913468,
-0.021677822,
-0.010490752,
-0.0012711086,
-0.01589707,
0.0031432842,
0.018721756,
-0.0077251876,
-0.004309288,
0.013729287,
-0.023228114,
-0.01350594,
-0.014412467,
-0.014451882,
0.0053340583,
-0.014241672,
-0.0025734203,
0.0046541626,
0.0044866526,
0.013387698,
-0.010444769,
0.024541922,
-0.01903707,
-0.00497933,
-0.0055278447,
0.013703011,
0.0017588597,
-0.024752133,
0.0015355124,
-0.010812635,
0.050397653,
-0.021257404,
-0.024055814,
-0.010188577,
-0.0064245183,
0.027432298,
0.0171846,
0.006493493,
-0.01902393,
-0.025566692,
0.02510686,
-0.015016818,
-0.013433681,
0.008066777,
-0.03055916,
-0.00429615,
0.019470626,
0.014084016,
-0.01091117,
-0.004939916,
0.005885857,
-0.013611045,
-0.014359915,
0.0036392466,
-0.03076937,
-0.0061420496,
-0.010083472,
0.036234807,
0.026184183,
0.04078058,
-0.009518535,
0.031452548,
0.008329539,
0.010576149,
-0.0030250417,
0.0019312969,
0.03200435,
-0.018261923,
0.015069371,
0.025435312,
-0.00055344135,
0.007876275,
-0.00477569,
0.011108242,
0.024660164,
-0.009104686,
-0.0075478237,
0.005022029,
-0.04072803,
-0.047323342,
0.021809204,
-0.0016365114,
0.0071602506,
-0.0342641,
-0.008618576,
0.011660041,
0.014570124,
-0.009144099,
-0.006690564,
0.031268615,
-0.012763639,
0.008349246,
-0.022558073,
-0.004598326,
0.0072062337,
0.008657991,
-0.0063325516,
-0.019470626,
-0.0005522097,
-0.006601882,
-0.0001656629,
0.029376734,
-0.014412467,
0.008375523,
-0.0021694244,
-0.02571121,
-0.023727361,
0.0011372645,
-0.027169537,
-0.0103199575,
-0.0030578868,
-0.027169537,
-0.023543429,
-0.015371547,
0.00859887,
-0.026959328,
0.00641138,
-0.009334601,
0.0045621963,
0.033948783,
0.0029232216,
0.02803665,
-0.021914307,
0.0010953869,
0.015529203,
-0.010365941,
0.0058300206,
0.00038264642,
-0.005465439,
0.0049826144,
0.03676033,
0.024449956,
-0.008460919,
-0.02188803,
0.004749414,
-0.004749414,
-0.011607489,
-0.038941253,
0.028457068,
0.00226796,
-0.0025898428,
-0.01118707,
-0.020639915,
-0.026407529,
0.000782126,
-0.015910208,
-0.0010403713,
0.0055179913,
0.0005920345,
-0.026223596,
0.03534142,
-0.0042337445,
0.012684811,
0.0045260666,
-0.020745018,
-0.02824686,
-0.016225522,
-0.013952635,
0.011949078,
-0.0132957315,
0.015187614,
-0.010549873,
-0.0043289955,
0.034500584,
-0.013479664,
-0.0054785768,
-0.007758033,
-0.003704937,
0.041463763,
-0.008270417,
-0.002680167,
0.025750626,
0.014924852,
-0.0075215474,
-0.004719853,
-0.0066478658,
-0.002983985,
-0.051396146,
-0.009919246,
0.028404517,
0.025356483,
-0.0050975727,
-0.013663597,
-0.02134937,
-0.00032147224,
-0.029455563,
-0.022190208,
0.004115502,
-0.03513121,
-0.014714643,
0.006595313,
0.026933052,
0.03268753,
-0.0016209099,
0.0022203345,
0.003514435,
0.036129706,
-0.0024716002,
0.01985163,
0.007455857,
0.031767864,
-0.0009705752,
0.00084412127,
-0.006365397,
-0.033659745,
-0.005389895,
-0.023175564,
-0.04283012,
-0.020784434,
-0.010379079,
0.015437237,
-0.0067168404,
-0.011903095,
0.0174605,
0.008973305,
0.015910208,
-0.0031892676,
0.0010600784,
0.019339245,
-0.0075675305,
-0.017026944,
0.015424099,
-0.019877907,
-0.004453807,
-0.0114826765,
-0.015778827,
-0.014031463,
-0.001589707,
-0.0060402295,
-0.020679329,
-0.0058070286,
-0.017210877,
-0.011088534,
0.003141642,
-0.012540292,
-0.018235646,
0.0004306825,
0.018853137,
-0.018984517,
-0.00081497116,
0.010090041,
0.029639496,
0.011141087,
-0.034158994,
0.009952092,
-0.019930458,
-0.009137531,
-0.011154225,
0.019838491,
-0.03838945,
0.031689037,
0.013013262,
0.003908577,
-0.01255343,
0.011338158,
-0.043723512,
-0.03996602,
0.015542341,
0.021993136,
-0.0040432424,
0.002983985,
0.0008556171,
-0.012507447,
-0.0039447066,
0.00487751,
0.0059384094,
-0.002704801,
0.012527154,
-0.016383179,
0.011995061,
0.018025437,
-0.0383369,
-0.007804016,
0.03405389,
0.0020544664,
-0.008211296,
-0.00497933,
-0.013992049,
0.024909789,
-0.00620774,
0.022400416,
-0.0017687132,
0.00975502,
0.022098241,
-0.023832466,
0.0022022696,
0.0088879075,
-0.0038330331,
0.0044308156,
0.0066741416,
-0.0026916629,
0.013768702,
0.005136987,
0.013354853,
-0.0052815056,
0.009433137,
-0.0024847384,
0.01861665,
0.017762676,
0.009853556,
0.020666191,
0.021638408,
-0.0019230857,
-0.01576569,
-0.007423012,
0.0052880747,
-0.0042928657,
0.0016496495,
0.0026686713,
-0.009925815,
0.0048578028,
-0.018603513,
-0.036865436,
0.005409602,
0.03137372,
0.0039545605,
-0.0069894553,
0.033607192,
-0.009998075,
-0.028273135,
-0.029271629,
-0.0075215474,
-0.033580918,
-0.0148722995,
-0.005820167,
0.0006831799,
-0.006982886,
-0.0028164748,
0.0067792465,
-0.0050384514,
0.007120836,
0.00873025,
-0.016370041,
-0.009873263,
0.00501546,
0.19192098,
-0.0064015267,
-0.015936485,
0.01916845,
-0.009768158,
-0.017381672,
0.01869548,
-0.001589707,
0.009768158,
0.0049826144,
0.014885438,
0.0056132423,
-0.014294225,
-0.0016521128,
0.02585573,
-0.011338158,
-0.006884351,
-0.002818117,
-0.009617071,
-0.03042778,
-0.016343765,
-0.0022597488,
0.009649916,
-0.014819748,
0.010352802,
-0.00852661,
-0.018104266,
0.00005342475,
0.026657153,
-0.008500334,
-0.01664594,
0.020364014,
-0.013992049,
-0.007468995,
0.01957573,
-0.003704937,
-0.0034553136,
-0.00016453385,
0.013532217,
-0.009702467,
0.012034476,
0.0019920606,
-0.013479664,
0.0034126148,
-0.0055245603,
0.018997656,
-0.02619732,
0.0072982004,
-0.0064212335,
-0.018800585,
-0.04380234,
0.017618157,
0.013952635,
0.009203221,
-0.003332144,
0.022965353,
0.020653052,
0.013157781,
-0.010727238,
0.0035965478,
-0.017407948,
0.002317228,
-0.011738869,
0.0014468305,
-0.015450375,
0.015450375,
-0.00723251,
0.010385647,
0.01575255,
-0.02271573,
-0.01446502,
-0.016974391,
0.0028673846,
0.008973305,
0.0046705855,
-0.01576569,
0.005156694,
-0.007784309,
0.0080602085,
0.023425186,
0.024581337,
-0.008086485,
-0.027668783,
-0.0060500833,
-0.0109571535,
-0.03875732,
0.016632803,
0.015883932,
-0.0064015267,
-0.014084016,
-0.00399069,
-0.012776777,
0.0010699319,
-0.018511547,
0.025264516,
0.008276987,
0.007928828,
0.007836862,
0.00995866,
-0.007830292,
-0.049819577,
0.073152795,
0.01889255,
0.0025110145,
-0.009314895,
0.013834392,
-0.0071011293,
-0.00033112054,
0.0034487445,
-0.008933891,
0.017499914,
-0.019076483,
0.011692886,
-0.0043224264,
-0.0023320082,
0.018708618,
-0.014346777,
-0.012310375,
0.057597317,
-0.020350877,
-0.014110291,
-0.023372633,
-0.00559682,
0.017276568,
-0.01568686,
0.01194251,
-0.021743514,
0.0049432004,
0.00236978,
-0.02196686,
-0.003294372,
-0.01474092,
-0.0035932632,
0.016409455,
0.025750626,
-0.02271573,
0.009196652,
0.003806757,
-0.009393723,
-0.00059326616,
-0.0078697065,
-0.0019608575,
0.018931964,
0.03568301,
0.0048019662,
-0.013078953,
0.023320083,
0.005833305,
-0.021677822,
-0.030795645,
0.00042534515,
-0.032976568,
-0.007225941,
-0.0053800414,
0.02898259,
-0.016133554,
-0.0371282,
-0.032582425,
-0.010497321,
0.014451882,
-0.03200435,
0.011200208,
-0.0037673428,
-0.022006275,
-0.012927865,
-0.014754057,
-0.16438359,
0.0062865685,
0.028614726,
-0.02182234,
0.016606526,
0.020626776,
-0.0157,
-0.0044439537,
-0.0012341578,
0.0214282,
0.05738711,
-0.00811933,
-0.052473467,
-0.022820834,
0.025356483,
0.0068580746,
0.022820834,
0.039387945,
0.01064184,
0.021953722,
0.032529872,
-0.0446169,
-0.0025882006,
-0.01493799,
-0.0022285457,
-0.016317489,
0.010904602,
-0.027931545,
-0.026722843,
-0.005156694,
0.015594894,
-0.0027376462,
0.01282276,
0.011022844,
0.0047986815,
0.012034476,
-0.005540983,
0.0060500833,
0.010208284,
0.006631443,
0.012284099,
0.02183548,
0.0019674266,
0.01583138,
0.0014279444,
0.02948184,
-0.022426693,
-0.017683849,
0.018196233,
-0.013900083,
0.03197807,
0.0020889537,
-0.0041319244,
0.0030414641,
0.0174605,
0.020613639,
0.013978911,
-0.007856568,
0.018984517,
-0.007994518,
-0.017513053,
-0.015358409,
0.01951004,
0.003236893,
-0.0022630333,
-0.027931545,
0.004920209,
0.00995866,
-0.02188803,
0.011489246,
-0.019457487,
-0.0014517572,
-0.00040912785,
-0.004604895,
0.041595142,
0.012297237,
0.004351987,
0.015437237,
-0.027537404,
0.0031170081,
-0.014767195,
0.009374016,
-0.0097944345,
-0.019352384,
-0.010352802,
-0.011338158,
0.010063765,
-0.007961673,
-0.010011213,
-0.013243179,
0.012507447,
-0.02701188,
-0.008296694,
0.006838368,
0.014399329,
0.01713205,
0.0023484307,
-0.002685094,
0.004013682,
-0.019628283,
0.033738576,
-0.021270541,
-0.019155312,
0.010694392,
0.015029957,
-0.006923765,
-0.006506631,
0.00804707,
0.034001336,
-0.025028031,
-0.013978911,
-0.0082835555,
0.011502384,
0.026407529,
0.0039414223,
0.046009537,
0.007646359,
0.003704937,
0.016488284,
-0.029692048,
0.05654627,
-0.0065263384,
0.010359371,
0.029639496,
0.03807414,
-0.01139728,
-0.12265706,
-0.024555061,
-0.008979874,
0.033239327,
-0.033265606,
0.02530393,
-0.0038724474,
0.0054785768,
-0.016961254,
0.030165019,
-0.00852661,
-0.016803596,
0.0033124369,
-0.012592844,
0.020416567,
-0.02121799,
0.025474725,
-0.008927321,
-0.041437484,
0.035446525,
0.013637321,
-0.008500334,
-0.011725731,
-0.020613639,
0.02012753,
0.04871598,
-0.05307782,
0.014294225,
0.020613639,
0.020298325,
-0.0028575312,
0.005350481,
0.004168054,
-0.010149162,
-0.019142173,
-0.002414121,
-0.002177636,
-0.038468283,
0.026933052,
-0.016829873,
0.012474601,
0.01602845,
0.028746106,
-0.014885438,
-0.012100167,
-0.021585856,
-0.039755814,
-0.0059318403,
0.026578324,
-0.026171044,
-0.030637989,
-0.022400416,
-0.00473956,
-0.0035045813,
0.017999161,
-0.023543429,
-0.0004458734,
0.023530291,
-0.0061519034,
-0.005156694,
0.004214037,
-0.018130543,
-0.0077054803,
0.003566987,
-0.00045121074,
-0.008835355,
-0.009242635,
-0.013834392,
0.017171463,
-0.0032894453,
0.013597907,
-0.016895564,
-0.022150792,
-0.01064184,
-0.01711891,
-0.0007849999,
0.011725731,
-0.009643346,
-0.0000597885,
-0.022124518,
-0.011265899,
-0.01500368,
0.016278073,
-0.027721336,
0.014543848,
0.00048734044,
0.00880251,
-0.012908158,
0.00067989534,
-0.017105773,
-0.004870941,
0.017644433,
-0.00545887,
-0.05129104,
0.014662091,
-0.0035899787,
-0.01698753,
0.023017906,
0.023963848,
0.006030376,
-0.011495815,
-0.006746401,
-0.052315813,
0.010109748,
-0.015043095,
-0.001387709,
0.009426569,
-0.012047614,
0.011968786,
-0.02893004,
0.011298744,
0.013808116,
0.0073376144,
0.0017194455,
0.009925815,
0.0043257107,
-0.027195813,
-0.0037279285,
0.0007743252,
-0.014819748,
-0.0011183786,
0.028325688,
-0.008290125,
0.011778284,
0.0032795917,
0.0052815056,
0.010937447,
-0.0036458157,
-0.005028598,
0.03725958,
-0.017276568,
-0.019904183,
0.0021119455,
-0.042199492,
-0.0107338065,
0.0012062395,
-0.011154225,
-0.0046771546,
0.004509644,
0.045273803,
0.009833848,
0.030270122,
-0.008520041,
-0.033712298,
0.022978492,
0.02367481,
-0.022098241,
0.0133023,
-0.027957821,
0.0057150624,
-0.0149511285,
0.0043848325,
0.024160918,
0.00525523,
0.0044439537,
-0.023293806,
-0.009328033,
-0.0035177195,
0.005445732,
-0.0035538492,
-0.032109454,
-0.0064245183,
0.010536736,
0.034211546,
0.011955648,
0.0054949997,
-0.015949622,
-0.0039118617,
-0.033712298,
0.004844665,
0.02006184,
-0.025290793,
-0.026249873,
-0.0017128764,
0.004742845,
0.008631715,
0.009741882,
-0.003609686,
0.0018524685,
0.016396316,
-0.0147277815,
0.028194306,
-0.0013655386,
0.0024157634,
0.0019230857,
0.009255773,
0.029297905,
-0.0024371129,
-0.017171463,
0.02463389,
0.0073507526,
-0.006165041,
0.0031153657,
0.028062927,
0.013939497,
-0.002647322,
0.0034323218,
0.028325688,
-0.028273135,
0.024384266,
0.022518659,
0.044038825,
-0.00047584463,
0.00021144089,
0.006936903,
-0.0070551457,
-0.000849048,
0.0020380437,
-0.025619244,
-0.016724769,
-0.017696986,
-0.00012553019,
0.008224434,
0.011968786,
0.0046541626,
-0.003008619,
-0.017972885,
0.0053767567,
0.007087991,
-0.009814141,
0.0000032941412,
0.024870375,
0.012566568,
0.024160918,
0.0009525104,
0.021099746,
0.011896526,
0.009636777,
0.009446275,
-0.011127949,
0.030217571,
-0.005041736,
0.025987111,
-0.013387698,
-0.015581756,
0.0009541526,
-0.02613163,
-0.02238728,
0.011029413,
-0.0009935668,
-0.025553554,
0.08403112,
0.020429706,
-0.015542341,
0.00852661,
-0.019693973,
0.0315051,
0.035761837,
0.024752133,
-0.016002174,
-0.017368535,
0.01255343,
-0.014359915,
0.023963848,
-0.038599662,
-0.0046213176,
0.020350877,
0.017631296,
0.011508953,
-0.01446502,
-0.0054687234,
0.0028969455,
0.013900083,
0.007258786,
0.015266442,
-0.032529872,
0.0038166104,
0.039177738,
-0.008644853,
0.009084978,
-0.010109748,
-0.006657719,
0.009472552,
-0.030927027,
0.0068055224,
0.01677732,
0.0028526043,
0.007895983,
-0.057334557,
0.0010543305,
0.02381933,
-0.013939497,
0.0026111922,
-0.0012497593,
-0.035393972,
-0.0119753545,
-0.02572435,
-0.014609539,
-0.020272048,
-0.004926778
] |
The cognitive deficits observed in children with cyanotic congenital heart disease suggest involvement of the developing hippocampus. Chronic postnatal hypoxia present during infancy in these children may play a role in these impairments. To understand the biochemical mechanisms of hippocampal injury in chronic hypoxia, a neurochemical profile consisting of 15 metabolite concentrations and 2 metabolite ratios in the hippocampus was evaluated in a rat model of chronic postnatal hypoxia using in vivo 1H NMR spectroscopy at 9.4 T. Chronic hypoxia was induced by continuously exposing rats (n = 23) to 10
|
[
-0.0074329027,
0.016212488,
0.024802493,
-0.053056676,
-0.047120813,
0.020291759,
-0.008727287,
0.0130419005,
-0.021690741,
-0.0033830495,
-0.0041904054,
0.015231894,
0.003067625,
0.0009389188,
0.00022737525,
-0.010786534,
0.027848871,
-0.0043440317,
-0.0006786528,
-0.013283781,
-0.030045401,
0.023063572,
0.0058508776,
-0.012028621,
0.003932182,
-0.0031852964,
0.016447831,
-0.02644989,
0.006831472,
-0.032503422,
0.014120555,
-0.011531786,
-0.014133628,
-0.023991868,
0.0012894812,
-0.015728729,
-0.01313996,
-0.0082173785,
0.0060175788,
0.0084984815,
0.011061101,
0.015088074,
-0.010989191,
0.013715242,
-0.0039844806,
-0.0067334124,
-0.009936687,
-0.02975776,
0.0017421887,
0.020344058,
0.02596613,
0.026515262,
0.019101972,
-0.0019252329,
0.021978382,
-0.015767952,
-0.0009021465,
0.012891543,
-0.0069099194,
-0.017467648,
0.012865393,
0.0021654784,
-0.011649457,
0.015584908,
-0.011394503,
0.00062390295,
0.015323416,
0.030803727,
0.0023452542,
0.004628404,
0.040060535,
0.03192814,
-0.005396536,
-0.0065830545,
0.018788181,
0.012113605,
-0.02722129,
-0.02200453,
-0.0007677234,
0.016421681,
0.0057985797,
-0.03388933,
-0.024436403,
0.043590672,
0.0221745,
-0.002642701,
-0.004602255,
0.023377363,
0.027770422,
0.010695012,
0.020984713,
0.030149998,
0.011420652,
-0.0076878574,
0.0075113503,
0.0024498508,
-0.00005766097,
0.030437639,
0.008112782,
-0.006671308,
-0.022945901,
0.004683971,
-0.020043341,
-0.01338184,
-0.01195671,
0.0012641492,
0.0018794719,
0.009812478,
0.021769188,
-0.010727699,
0.00026333035,
0.03519679,
-0.0045368816,
-0.018265199,
-0.008393885,
0.00040183926,
0.023586556,
0.017624544,
-0.0012894812,
-0.017977558,
0.012904618,
0.010158954,
0.001915427,
-0.019271942,
-0.0129503785,
0.0083154375,
-0.009799403,
-0.018618213,
0.0063150255,
-0.017925259,
-0.018016782,
0.008943018,
0.013277243,
-0.0062790704,
-0.035066042,
0.023024349,
-0.01710156,
-0.01171483,
-0.020592475,
-0.026881352,
-0.0064196223,
0.014002883,
-0.02118083,
-0.008380811,
-0.010799609,
0.025770012,
-0.0035072581,
0.04398291,
0.005164462,
-0.02374345,
-0.0022275827,
-0.016761621,
-0.020500952,
-0.012643126,
0.004850672,
0.028973285,
-0.0017258455,
0.015663356,
-0.0117605915,
-0.031771246,
-0.0062954137,
-0.016617801,
-0.0020183893,
0.01992567,
0.010878056,
-0.0009430046,
0.01393751,
-0.010015134,
0.034621507,
-0.035249088,
-0.013715242,
0.0023011274,
-0.031457458,
0.0086946,
0.0042459723,
0.01710156,
0.018984301,
0.023887271,
-0.0084069595,
-0.02727359,
-0.017193083,
0.017480724,
-0.0049748803,
-0.008341586,
-0.0083154375,
-0.006285608,
0.03365399,
-0.0013605743,
0.008184692,
-0.014368972,
-0.009459464,
0.008289289,
-0.019651104,
-0.02101086,
-0.6493363,
-0.022475215,
-0.008452721,
-0.01538879,
0.0033895867,
0.02465867,
-0.0015493386,
0.0034190046,
-0.004007361,
0.035405982,
0.00026721187,
0.030568385,
-0.011106862,
-0.011100325,
-0.005592655,
-0.026737532,
-0.0063379062,
-0.010472745,
0.039093018,
-0.011466413,
-0.007968961,
-0.011577547,
-0.0069360686,
0.0076551707,
0.01806908,
0.044427447,
0.035693623,
-0.010793072,
-0.0074786637,
0.029130181,
0.00857693,
0.00806702,
-0.0018860092,
0.022619035,
0.04882051,
-0.01118531,
-0.015271118,
0.04147259,
-0.0057430123,
0.020487878,
0.00050909177,
0.0015893795,
0.023978792,
-0.0030529161,
-0.0013483168,
0.023508107,
-0.00007328919,
0.0017013306,
0.0105838785,
-0.009511762,
-0.009622896,
-0.028920988,
-0.004602255,
0.010825758,
-0.006798785,
-0.045734905,
0.005988161,
-0.019350389,
0.01710156,
0.0024972463,
-0.017964482,
0.008871107,
-0.018945077,
-0.024985537,
-0.004330957,
0.035405982,
-0.024174912,
-0.0064719208,
-0.004755881,
-0.00768132,
0.011512174,
0.029940804,
0.0018157333,
-0.0061221756,
0.01710156,
0.0019873374,
0.032189634,
0.0045303446,
-0.01997797,
0.03135286,
0.010642714,
0.012277038,
-0.039197613,
-0.015009626,
0.032189634,
0.009086838,
-0.024554076,
0.009747105,
-0.0119436355,
-0.013662944,
0.00052175776,
0.006877233,
0.0009372845,
-0.052847482,
-0.012205128,
0.023900345,
-0.022605961,
0.018578988,
0.017402276,
-0.005635147,
-0.015571834,
-0.0047689555,
-0.025573893,
0.0039289133,
0.008302363,
0.020187162,
-0.011747517,
-0.01616019,
0.051173933,
-0.027848871,
-0.026240697,
-0.013146497,
0.007217172,
0.005285402,
0.006053534,
-0.018918928,
0.016892366,
0.0003029627,
-0.020710146,
-0.022135276,
0.030202296,
-0.0051971483,
-0.00045148184,
-0.012708499,
-0.0043473,
0.0014635366,
-0.0013622085,
0.004174062,
-0.0089495545,
-0.017023113,
0.008943018,
0.0069556804,
0.022540588,
-0.0060045044,
0.01021779,
0.010132805,
0.025247028,
-0.0008318706,
-0.009184898,
-0.012937304,
-0.0060764146,
0.022383694,
-0.008688063,
-0.009681731,
-0.024841717,
0.000010559262,
-0.019415762,
0.00216221,
-0.02094549,
0.01881433,
-0.012263963,
-0.01966418,
-0.020226387,
0.028267257,
0.004386524,
-0.011780203,
0.0021540383,
0.0047722245,
-0.006210429,
-0.009544449,
0.010727699,
0.03132671,
-0.008321974,
0.012728111,
-0.022945901,
-0.02231832,
0.0071779485,
0.0002347297,
-0.00011562838,
-0.024907088,
-0.019219643,
-0.020683996,
-0.002876409,
-0.017363051,
0.016748546,
0.02975776,
-0.021141607,
-0.012250888,
-0.025207805,
0.00008472946,
0.025613116,
-0.01553261,
-0.025390849,
0.0017421887,
0.015885623,
0.002319105,
0.020370208,
0.01946806,
0.004814717,
0.041917127,
0.0011244145,
0.03705338,
-0.023246616,
-0.0016531182,
0.0086815255,
-0.02248829,
-0.011296444,
-0.016081743,
0.0033503629,
0.050807845,
0.016683172,
-0.023965718,
0.016382458,
0.00085638545,
0.02818881,
-0.0134799,
-0.0117605915,
-0.002324008,
-0.014604314,
-0.012388172,
-0.0076878574,
0.016643949,
0.024201062,
-0.011061101,
-0.030254595,
0.017951408,
-0.009740568,
-0.000111236135,
-0.007236784,
-0.019546509,
0.029339373,
-0.01610789,
0.018056005,
0.012734648,
-0.0012216568,
-0.0072694705,
0.010322386,
0.018291347,
0.0020330984,
0.0000412922,
0.011067638,
0.009269882,
-0.009426777,
0.013545272,
-0.009969373,
0.0049552685,
0.00526579,
-0.0044551655,
0.0056122667,
0.049395792,
-0.013806764,
0.023377363,
0.010315849,
-0.017820662,
0.0032179828,
0.0087665105,
0.01693159,
0.018618213,
-0.016826995,
0.0047591496,
-0.017637618,
0.0049454626,
-0.016356308,
0.0016032712,
-0.0062888763,
0.009557523,
0.00799511,
0.02220065,
0.011165697,
0.0114925625,
0.0089495545,
0.0014324845,
-0.0026002086,
-0.010113194,
-0.010786534,
-0.0067791734,
-0.0037262575,
0.0071060383,
-0.012603902,
-0.012348948,
-0.03394163,
-0.008759974,
-0.024031091,
-0.016081743,
0.030960623,
-0.0039354507,
-0.017964482,
0.009433315,
0.028267257,
0.0050042984,
0.00084004225,
-0.009655583,
0.022161426,
0.023037422,
-0.010204716,
0.0042623156,
-0.023665003,
0.017232306,
-0.030856026,
0.016251711,
-0.007184486,
0.0103093125,
0.01707541,
-0.0060175788,
-0.022239873,
-0.037262574,
0.012250888,
0.0034091987,
0.008380811,
-0.0050141043,
-0.019454986,
0.008511556,
-0.0205794,
0.0056972513,
0.028685644,
0.01345375,
-0.002712977,
0.0042361664,
-0.0058247284,
0.009969373,
0.020500952,
-0.008524631,
0.017899109,
0.014264375,
0.014565091,
0.004170793,
-0.014042106,
0.009413702,
0.0063379062,
0.007890513,
-0.006962218,
-0.020814743,
-0.0013360594,
-0.01678777,
0.03823009,
0.0061679366,
-0.01536264,
0.018578988,
0.0031558785,
-0.012558141,
-0.0022406573,
-0.018565914,
0.028371854,
0.015258043,
0.015637206,
-0.0025086864,
0.009779791,
0.006831472,
0.009792866,
0.011211459,
0.013159572,
-0.0022668066,
-0.012786946,
0.00872075,
-0.010224327,
-0.0030561849,
0.0012755895,
0.042100172,
0.018160602,
-0.0072237095,
0.027142843,
0.035092194,
0.018461317,
-0.016617801,
-0.011263757,
0.007145262,
-0.010793072,
0.010204716,
-0.014303599,
-0.00072482246,
0.0021507696,
-0.005939131,
0.04842827,
0.0174415,
0.018748958,
0.008413497,
0.009819015,
0.004386524,
0.017689917,
0.011002265,
0.022279097,
0.009609821,
0.005488058,
-0.022998199,
0.013676018,
-0.01995182,
-0.01550646,
-0.019311165,
0.020330982,
-0.020827817,
0.016944665,
-0.002273344,
0.01823905,
0.011126474,
-0.015336491,
-0.027090544,
-0.00011491337,
-0.010054357,
-0.0017748752,
-0.003618392,
-0.0055501624,
-0.003396124,
-0.030934473,
-0.0045205387,
0.009819015,
-0.0015035776,
-0.04113265,
0.0031509756,
0.028764091,
0.021050086,
0.033470944,
-0.027299738,
0.009335255,
0.009112988,
-0.0109499665,
-0.01852669,
-0.019389613,
0.006792248,
0.025351625,
0.0049912236,
-0.0104008345,
-0.028554898,
-0.0016089914,
0.00557958,
0.02451485,
-0.005635147,
0.011603696,
0.014029033,
-0.0050304476,
0.011963247,
0.020644773,
0.03075143,
0.0019088897,
-0.014839657,
-0.003997555,
-0.027796572,
-0.009296032,
-0.019193495,
0.0009585307,
-0.021952232,
-0.029548567,
0.018762033,
0.004056391,
-0.01219859,
0.022449067,
-0.009047614,
0.019101972,
0.0046774335,
0.0074198283,
0.022619035,
-0.020187162,
0.029365523,
0.005592655,
-0.0070929634,
0.014708911,
-0.013172647,
0.018291347,
-0.012473157,
-0.027665827,
0.010727699,
0.0005626158,
-0.03673959,
-0.03605971,
0.013159572,
0.00857693,
0.02584846,
0.002712977,
-0.028711794,
-0.013924436,
-0.000114606926,
-0.00041430097,
-0.010119731,
-0.0008433109,
-0.005056597,
0.003249035,
-0.010185104,
-0.0012829439,
-0.03354939,
0.05297823,
-0.031169817,
-0.021337727,
-0.011250682,
0.001874569,
-0.009139136,
-0.018474393,
0.0063542495,
-0.042675454,
0.0073806043,
-0.0104923565,
-0.031901993,
-0.0024841717,
0.0075963354,
0.021743039,
0.013440676,
0.023926495,
0.002410627,
0.027665827,
0.0118848,
0.014787358,
-0.0065928604,
0.014565091,
0.0010982653,
-0.0153103415,
0.005739744,
-0.024410255,
0.012074381,
-0.0065046074,
-0.01050543,
0.019964894,
0.028581047,
-0.013780615,
-0.023651928,
0.0025381043,
-0.01125722,
-0.013649869,
-0.001556693,
-0.01596407,
0.0058999076,
-0.04400906,
-0.016578577,
0.03904072,
-0.010139342,
0.010655789,
-0.04725156,
0.012460082,
-0.02465867,
-0.0048179855,
-0.00004124113,
0.0076420964,
0.010485819,
-0.03765481,
0.0032621096,
-0.0020592476,
0.004729732,
-0.0032277887,
0.0075963354,
0.005684177,
0.00019642524,
-0.0067007258,
-0.0033389227,
-0.011695218,
-0.0058279973,
-0.015271118,
-0.009943224,
-0.02345581,
-0.0017111367,
0.0071583367,
-0.0221745,
0.008884182,
-0.0012314627,
-0.027482782,
0.027613528,
-0.04060967,
0.012832708,
-0.0018892778,
-0.017781438,
0.018108303,
-0.025037834,
0.05229835,
-0.00096261647,
-0.015545684,
-0.010374685,
0.0013613914,
0.016094817,
-0.0015076633,
0.04207402,
0.010714624,
-0.030228445,
0.010616565,
-0.0038831525,
0.021638442,
-0.0017781439,
-0.008420034,
0.0097667165,
0.0066582337,
-0.024475627,
0.0019971433,
-0.018435167,
-0.04181253,
0.0071975603,
-0.017180007,
-0.017454574,
-0.010498893,
-0.03360169,
-0.020200238,
0.023338139,
-0.011590621,
0.018134452,
0.009282957,
0.01108725,
-0.019141195,
0.004134838,
-0.03226808,
0.023390437,
0.005997967,
0.018827405,
-0.0116756065,
0.0116690695,
-0.0029221703,
-0.0032768184,
0.007576723,
-0.00019683382,
-0.025534669,
0.037210274,
0.020082567,
-0.009871313,
0.024044165,
0.013728317,
0.0014104211,
-0.014159778,
-0.0060143103,
-0.0411588,
-0.016918516,
0.00071828516,
0.018892778,
-0.0045140013,
-0.018173676,
-0.005478252,
-0.013492974,
-0.007798991,
-0.020252535,
-0.02314202,
0.0059097135,
-0.030123848,
0.007230247,
0.00644904,
0.0011865188,
0.010237402,
-0.012728111,
-0.0129438415,
-0.010557729,
0.022592887,
-0.017010039,
0.035981264,
0.015284193,
0.015833326,
-0.022501364,
0.012120143,
-0.022553664,
-0.016657025,
0.008230452,
-0.00024821286,
-0.044244405,
0.0009928514,
0.003533407,
0.016578577,
-0.0070733516,
0.0021801875,
0.01729768,
-0.0043473,
-0.01550646,
0.0023174705,
-0.026240697,
0.024004942,
-0.031091368,
-0.001071299,
0.014146703,
-0.040688116,
-0.002203068,
-0.021638442,
0.0055566994,
0.0049944925,
-0.022396768,
-0.006684383,
0.002016755,
0.01613404,
-0.027508931,
-0.014185927,
-0.026855202,
-0.0108584445,
-0.030202296,
0.017036187,
0.0052984767,
0.003608586,
-0.010511968,
0.023181243,
0.0072956197,
-0.011564473,
-0.011250682,
0.007772842,
0.01181289,
-0.014708911,
-0.03422927,
0.023442734,
-0.0038014362,
0.027953468,
0.007877439,
-0.028136512,
-0.023338139,
-0.014225151,
-0.044819687,
-0.007857827,
0.0038145108,
-0.0010394297,
0.004278659,
0.013832914,
0.0041773305,
0.020683996,
-0.0068903076,
0.027325887,
0.0023632317,
-0.0072106346,
0.020932414,
-0.0056776395,
0.024305658,
-0.004125032,
-0.0047460753,
-0.01376754,
0.025207805,
0.006962218,
-0.008511556,
0.027090544,
0.009269882,
0.0050827456,
-0.019651104,
0.014355897,
0.024724044,
-0.019938746,
-0.017572245,
-0.0071779485,
-0.0035660937,
-0.0055959234,
0.0063509806,
-0.0011546495,
-0.012590827,
0.014525866,
0.001081105,
-0.0056188037,
-0.028005766,
-0.0040956144,
0.023926495,
-0.009119525,
0.011054563,
0.017023113,
-0.028031915,
0.015192671,
0.028894838,
-0.020514028,
-0.02188686,
0.0034124672,
0.00010561815,
-0.006589592,
-0.0034484223,
-0.02362578,
-0.0049585374,
0.0037589439,
0.0075178877,
-0.038151644,
-0.010322386,
-0.013192259,
-0.007262933,
-0.026515262,
0.020487878,
-0.0064555774,
-0.0035791683,
-0.012420858,
0.0058410717,
-0.0023109333,
0.013898286,
-0.010557729,
-0.007191023,
-0.013172647,
-0.020043341,
0.006792248,
-0.00086373993,
-0.009988985,
-0.016526278,
-0.004425748,
0.0068249344,
0.013466825,
0.16620415,
-0.0012265597,
0.0042950017,
0.0019268673,
-0.012891543,
-0.008073557,
0.01550646,
0.015637206,
-0.004062928,
0.00432442,
0.014643538,
0.0050042984,
-0.012178978,
-0.0005291122,
0.00026353466,
-0.023926495,
-0.031222114,
-0.011021877,
-0.025482371,
-0.020357132,
-0.0124927685,
-0.004278659,
0.0316928,
-0.0061973543,
0.007720544,
-0.0016800845,
-0.0073609925,
0.0074459775,
0.013205333,
0.008759974,
-0.0074067535,
0.011133011,
-0.013924436,
0.0042034797,
-0.0074655893,
-0.009296032,
-0.00005643523,
-0.0022292172,
-0.008335049,
-0.014617388,
-0.0028224764,
0.026855202,
-0.00862269,
0.016513204,
-0.018631287,
0.04696392,
0.016565502,
-0.027482782,
-0.016604725,
-0.006929531,
-0.027142843,
-0.0034745715,
0.018147526,
0.03075143,
-0.0017732409,
0.00077630364,
0.004334226,
0.011878262,
-0.01538879,
0.020527102,
-0.02627992,
0.009812478,
0.006413085,
0.026175324,
-0.0009748739,
0.020827817,
-0.009165286,
-0.0021948963,
-0.025247028,
-0.010172029,
0.019206569,
-0.040322028,
-0.03700108,
-0.015663356,
-0.018709734,
-0.016866218,
0.03681804,
0.012963453,
-0.014617388,
0.021193907,
0.015258043,
-0.015833326,
-0.03106522,
0.010649252,
-0.0108584445,
-0.046336338,
0.021965306,
0.023834972,
-0.020814743,
0.006190817,
0.019873373,
-0.009799403,
-0.014643538,
0.007498276,
0.009086838,
-0.010198178,
0.0023583288,
0.019886447,
-0.008733824,
0.011799815,
-0.027770422,
0.075152725,
0.0021458666,
0.015336491,
-0.0014422904,
-0.009302569,
-0.0018909122,
0.02229217,
0.0036151235,
0.0075178877,
-0.009838627,
-0.018147526,
-0.00932218,
-0.014774283,
-0.005053328,
0.039249912,
0.009792866,
-0.034516912,
0.018108303,
-0.009354867,
0.0011415749,
-0.009367942,
0.010982653,
0.022357544,
-0.009642508,
-0.022043753,
-0.03221578,
0.0015950997,
-0.0057332064,
-0.052847482,
0.012303187,
-0.00802126,
0.006439234,
0.0070602773,
-0.0047722245,
0.009701344,
0.013924436,
0.009165286,
0.002830648,
0.021808412,
-0.004402867,
-0.016094817,
0.011590621,
0.015741803,
0.015911773,
-0.03229423,
0.005324626,
-0.011486025,
-0.0056972513,
-0.01050543,
-0.009884388,
-0.0043767183,
0.0068641584,
-0.0007334026,
0.012205128,
-0.044427447,
-0.0060404595,
-0.033680137,
-0.011688681,
-0.008929943,
-0.018618213,
0.016800845,
0.0077793794,
-0.0052919392,
-0.018448243,
0.010878056,
-0.16327545,
-0.010551192,
0.016500128,
-0.031248264,
0.0058541466,
-0.001586928,
0.0285026,
0.0046970453,
0.013584496,
0.0007922383,
0.03137901,
-0.008668452,
-0.012741186,
-0.024632523,
0.0072433213,
-0.00014310544,
-0.0063967416,
0.026070727,
0.0034288105,
-0.014133628,
0.018592063,
-0.020644773,
0.023155093,
0.012839245,
0.011335667,
-0.00027967358,
-0.010511968,
0.02009564,
-0.0018582257,
-0.008387348,
-0.020383282,
-0.01992567,
0.038203944,
-0.0023926494,
0.005484789,
-0.000116547686,
0.010165491,
-0.013636795,
-0.009819015,
0.012865393,
-0.005533819,
0.027822722,
-0.0024727313,
-0.0152188195,
-0.030646833,
0.005994698,
0.0098582385,
-0.018108303,
0.016290937,
0.0037426006,
0.014473568,
-0.014342822,
0.024946313,
0.014787358,
0.0018108303,
-0.0029172674,
0.00025761023,
0.019389613,
-0.020043341,
-0.008073557,
-0.007308694,
-0.03616431,
0.0025707907,
0.015571834,
0.026005354,
-0.02248829,
0.006720338,
-0.007236784,
-0.038151644,
0.010740774,
-0.009139136,
-0.026476039,
0.017716065,
-0.011721367,
0.027430484,
0.011845576,
-0.024201062,
-0.000005151949,
-0.00340593,
0.04147259,
-0.0067007258,
0.0061319815,
-0.049526535,
-0.009609821,
-0.02482864,
-0.0021082773,
-0.00855078,
-0.018343646,
0.0062496527,
-0.0053409687,
0.0038831525,
-0.04523807,
0.0035530191,
0.0088580325,
0.01823905,
0.0114925625,
-0.00044984752,
-0.010270088,
0.022815155,
-0.01306805,
0.010832296,
0.010989191,
-0.012813096,
0.0032751842,
0.03990364,
0.010904206,
-0.011250682,
0.004925851,
0.047303855,
-0.010734236,
0.005707057,
0.0023076646,
0.0005679274,
0.017258456,
-0.0012298283,
0.00032625181,
-0.014447419,
-0.01715386,
0.007720544,
0.0011497465,
0.080957845,
0.007825141,
-0.02818881,
0.01487888,
0.0015321781,
-0.0026819247,
-0.14047337,
-0.038125496,
-0.008635765,
0.018827405,
0.019507283,
0.015650282,
-0.002183456,
0.00371972,
0.005615535,
0.032111187,
-0.021337727,
-0.009792866,
0.004821254,
0.0049846866,
0.03611201,
-0.0032326917,
0.009452927,
0.012080919,
-0.011368354,
0.035615176,
0.008374273,
-0.0035889742,
0.0026492383,
-0.010779997,
0.0015158349,
-0.023834972,
-0.027796572,
0.020357132,
0.01536264,
0.006746487,
0.028345706,
-0.0054913266,
0.010904206,
0.0052004172,
-0.01229665,
0.00023064388,
0.028633347,
-0.011361816,
0.044793535,
-0.0071060383,
0.007831678,
0.025037834,
0.03705338,
0.012002471,
0.022252947,
-0.004360375,
-0.02485479,
-0.00705374,
-0.0041446444,
-0.009511762,
-0.02186071,
0.0026753873,
-0.0037131829,
-0.0033470944,
0.02852875,
-0.04155104,
0.020043341,
0.03386318,
-0.017990632,
-0.0007644548,
0.020592475,
-0.002997349,
-0.014891955,
0.02422721,
0.041341845,
-0.023560407,
-0.032869514,
-0.040322028,
-0.0018353452,
-0.05159232,
0.006857621,
0.0123097235,
0.01181289,
-0.0074786637,
-0.027038246,
-0.0015991854,
-0.009590209,
-0.012394709,
0.0021899934,
0.004510733,
-0.0062888763,
-0.008178154,
0.028842539,
-0.0020298297,
-0.011930561,
0.030176148,
0.0024531195,
-0.003608586,
-0.0008089901,
-0.009243733,
-0.010806146,
0.027064396,
0.0012715036,
-0.029627014,
-0.00587049,
-0.0051971483,
-0.0012314627,
-0.0042525097,
0.015519535,
-0.0018827405,
-0.014238225,
-0.034621507,
-0.032424975,
0.028607197,
0.001263332,
-0.018997375,
0.011309518,
0.0019775312,
0.01550646,
-0.004017167,
-0.0021883592,
-0.0052592526,
-0.029182479,
-0.00013391237,
-0.012597364,
0.002304396,
-0.022945901,
-0.000707662,
0.025613116,
0.01963803,
0.00997591,
0.011191847,
0.02599228,
0.010394297,
-0.014682761,
0.03833469,
-0.008256602,
-0.023128945,
-0.0011660898,
0.016356308,
-0.004814717,
0.0010377953,
0.013832914,
-0.03221578,
0.029313225,
0.0054913266,
-0.0013033729,
-0.004916045,
0.009792866,
0.001349134,
0.013153035,
0.053710405,
-0.019206569,
-0.006798785,
-0.0033389227,
-0.015597982,
0.023952644,
0.010132805,
-0.04024358,
0.014434344,
0.011806352,
-0.031091368,
0.027299738,
0.018971225,
0.0011758957,
-0.011381428,
-0.043904465,
0.021390025,
-0.010688475,
0.011381428,
0.008727287,
-0.013532198,
0.016487055,
-0.018932002,
0.031300563,
-0.014303599,
0.01610789,
-0.013793689,
0.016460905,
0.0008596541,
0.0033438257,
-0.0023730376,
-0.02818881,
-0.008282751,
0.012832708,
0.0109499665,
-0.003219617,
-0.010851908,
-0.0002623089,
0.01758532,
-0.00014770198,
0.007276008,
0.007883976,
-0.007524425,
-0.017650694,
0.016212488,
0.02973161,
-0.014656613,
-0.00095526205,
0.03386318,
0.0070864265,
-0.00012706865,
0.0008277848,
0.0012666007,
0.0061058323,
-0.0051121637,
-0.00095444487,
0.027378187,
-0.009315643,
-0.010381223,
0.010747311,
0.012362022,
0.0004841683,
-0.0034091987,
-0.003932182,
0.0022096052,
-0.010851908,
0.0020232925,
-0.012460082,
-0.03443846,
0.012028621,
0.014669687,
0.012701961,
0.023521183,
0.00017701766,
0.003785093,
-0.018762033,
0.0026574098,
-0.0065961294,
0.015480312,
-0.009897462,
0.02043558,
-0.0097667165,
-0.003925645,
0.029260926,
0.005432491,
0.024410255,
-0.006753024,
0.030489938,
-0.014669687,
0.01362372,
0.0039485255,
0.023037422,
0.013303393,
-0.04947424,
0.0038798838,
0.010198178,
-0.024436403,
0.010178566,
0.0068706954,
0.009191435,
0.073060796,
-0.00656998,
-0.033784732,
-0.020213312,
-0.0044224793,
0.013061512,
-0.0057037887,
0.007007979,
0.00813893,
-0.024331806,
0.027796572,
-0.03221578,
0.031535905,
-0.036896486,
-0.010819221,
-0.0080408715,
0.0029532225,
0.020291759,
0.0444013,
-0.00862269,
0.0028273794,
-0.01618634,
0.016212488,
0.016395532,
-0.025887683,
0.014748135,
0.045081176,
-0.046310186,
-0.014957327,
-0.0108584445,
0.014983477,
0.012630051,
-0.040008236,
-0.01695774,
-0.0008661914,
-0.009269882,
-0.011525249,
0.0009176726,
-0.004147913,
0.009459464,
0.0033634375,
0.0005503584,
-0.022422917,
-0.020344058,
-0.011995934,
-0.016826995,
0.010662326,
-0.018225975,
-0.019559583
] |
Nuclear transcription is not restricted to genes but occurs throughout the intergenic and noncoding space of eukaryotic genomes. The functional significance of this widespread noncoding transcription is mostly unknown. We show that Arabidopsis RNA polymerase IVb/Pol V, a multisubunit nuclear enzyme required for siRNA-mediated gene silencing of transposons and other repeats, transcribes intergenic and noncoding sequences, thereby facilitating heterochromatin formation and silencing of overlapping and adjacent genes. Pol IVb/Pol V transcription requires the chromatin-remodeling protein DRD1 but is independent of siRNA biogenesis.
|
[
-0.049848814,
-0.02015887,
-0.001488414,
-0.014831915,
-0.025642501,
0.014087708,
-0.019884689,
0.0035153988,
-0.031439483,
-0.008897844,
0.015288884,
-0.012782082,
-0.0083755925,
-0.0008396809,
0.0040311213,
-0.0029180748,
0.021751733,
-0.0115547925,
0.011398118,
0.00053857086,
-0.00901535,
0.029533267,
0.0010183885,
-0.0024105127,
-0.018082924,
0.035016898,
0.009243834,
-0.039952166,
-0.019323269,
-0.026817564,
0.009576769,
0.015262771,
-0.0029882523,
-0.0052225054,
0.00082050456,
-0.02739204,
-0.0036133209,
-0.027418153,
0.0026373651,
0.00025459714,
0.025081081,
0.010236111,
-0.011744109,
-0.003022525,
-0.0006426129,
-0.0039397273,
0.012325113,
-0.010046794,
0.004781856,
0.018670456,
0.021986747,
0.02120337,
-0.01488414,
-0.008153636,
-0.007494295,
-0.003319555,
0.0018980543,
0.018840188,
-0.0005300027,
-0.010536404,
-0.010281807,
-0.0023484954,
-0.01530194,
0.01233164,
-0.014035483,
0.016764242,
0.0046317093,
-0.009589825,
-0.010960733,
0.004703519,
0.031256694,
0.016255047,
-0.021059752,
0.00536286,
0.020903077,
-0.034129072,
-0.002676534,
-0.0016328489,
-0.007291923,
0.0140746515,
0.01477969,
-0.007135248,
0.012873475,
0.025642501,
0.011789805,
0.008447402,
0.0058753183,
0.023775455,
0.0074551264,
0.0016279528,
0.023488218,
0.032379534,
0.028436542,
0.017730406,
-0.01509304,
-0.012573182,
0.016516173,
0.023318486,
0.0052779946,
-0.01411382,
-0.014636071,
0.010804058,
-0.00022889262,
-0.0072723385,
-0.04465242,
0.006958988,
0.013604626,
0.009596353,
0.018709624,
-0.024023524,
-0.030342756,
0.037288688,
-0.008930484,
-0.033006232,
0.040970553,
-0.018095981,
0.033110682,
0.0024562094,
-0.018422388,
-0.031831168,
0.022835404,
0.0383593,
0.02205203,
-0.045461908,
0.027209252,
0.015941698,
0.005473838,
0.01649006,
-0.022835404,
-0.00075195916,
0.006355136,
0.013513233,
0.0129387565,
0.00674356,
-0.023997411,
-0.0075530484,
-0.028697666,
-0.021007527,
0.0009237306,
-0.047864262,
-0.009694275,
0.013787414,
-0.034677435,
-0.002976828,
0.007872927,
0.012932229,
0.029115466,
0.0059862966,
0.030629992,
0.005715379,
-0.0074681826,
0.0065640365,
0.012560125,
-0.02239149,
-0.0030111007,
0.0061331796,
-0.0026634778,
0.0043314155,
0.0027662958,
-0.0020694176,
0.0076313857,
-0.004380376,
0.0026961183,
0.02082474,
0.023697117,
0.031047793,
-0.016646735,
-0.018774906,
-0.0016777298,
-0.022456773,
0.0047851205,
0.011398118,
-0.049352676,
0.018631287,
-0.008179748,
0.010960733,
0.0000050076633,
0.007977377,
-0.011391589,
0.002433361,
0.004605597,
0.016751185,
0.03112613,
0.015132209,
-0.025289983,
0.001978024,
0.009348284,
-0.00022930063,
-0.019453833,
0.0018898941,
-0.017939305,
0.011639658,
0.027548715,
-0.0064302096,
-0.63631004,
-0.016346442,
0.01613754,
-0.01834405,
0.016020035,
0.021464497,
-0.0051931287,
0.006893707,
-0.010477651,
0.026360596,
-0.036087513,
0.019819407,
0.040866103,
-0.026230033,
-0.048438735,
-0.056664184,
-0.007350676,
-0.009374397,
0.039012115,
0.022757066,
-0.015393334,
-0.00030784222,
0.007324564,
0.016933974,
0.022156479,
0.0022114045,
0.012344697,
-0.008812978,
-0.0101055475,
0.018017642,
-0.018082924,
0.014740521,
-0.027757615,
-0.00901535,
0.045827482,
0.01978024,
-0.00415842,
0.03483411,
0.022038972,
0.013983258,
-0.0043966966,
-0.00814058,
0.03895989,
0.0065934127,
-0.0122467745,
0.024780788,
-0.0072005293,
0.009870535,
-0.0054771025,
-0.025838345,
-0.014244383,
0.024937462,
-0.018814076,
0.009785669,
-0.0043412074,
0.006260478,
0.012396921,
-0.014871084,
0.019297156,
-0.0029654037,
-0.011078239,
0.007892511,
-0.002479058,
-0.01534111,
-0.0068806508,
-0.027914291,
-0.027627053,
0.004527259,
-0.00016279529,
-0.002825049,
0.015419447,
0.011163105,
0.023318486,
-0.0042498135,
0.0042857183,
0.01509304,
0.015014702,
0.0031873602,
0.0048275534,
0.02651727,
-0.021568947,
-0.02149061,
-0.041101117,
-0.0077097234,
0.030734444,
-0.007083023,
-0.016581453,
0.04021329,
0.0052943146,
-0.012338169,
-0.0014043642,
0.006097275,
-0.020276377,
-0.043346792,
-0.05478408,
-0.0026128846,
-0.009002293,
0.016581453,
-0.0007066702,
-0.011698412,
-0.0029050186,
-0.00067321357,
-0.014740521,
-0.006998157,
-0.00094168296,
-0.022078142,
-0.022443715,
-0.0024186727,
0.018814076,
-0.007846815,
0.0070242696,
-0.013983258,
-0.010242638,
-0.003029053,
-0.0054477258,
-0.019858576,
0.025629444,
0.00009389289,
0.004775328,
-0.01331086,
-0.010549461,
-0.010072907,
-0.02267873,
0.0025720838,
-0.0013782518,
-0.0040507056,
0.019088257,
-0.021164203,
-0.007938208,
0.0039103506,
-0.0056272494,
0.00040576418,
0.028488766,
-0.017456224,
0.010392785,
-0.006250686,
0.035800274,
0.018487668,
0.015876416,
-0.026687002,
-0.015014702,
0.012703744,
-0.0011677195,
0.009570241,
0.00061119633,
-0.0094135655,
-0.03206618,
0.00842129,
0.009302587,
0.0037699959,
-0.0020955303,
0.010249167,
-0.011130464,
0.016346442,
0.001978024,
-0.012240247,
-0.029272143,
-0.033946283,
-0.022156479,
0.0036067928,
0.014335777,
0.0033456674,
-0.011698412,
0.02072029,
-0.0028119928,
0.0035872082,
-0.012605822,
0.013369613,
-0.019558283,
-0.024937462,
0.013062791,
-0.0020498333,
-0.010014154,
0.0009669795,
-0.010209998,
0.009563712,
0.0007152384,
0.014179102,
-0.01093462,
-0.009974985,
-0.015171378,
0.0073702605,
-0.027940404,
-0.016672848,
0.02532915,
0.021307822,
0.03206618,
-0.0009800358,
0.016189767,
0.019310214,
0.00022522054,
0.012586238,
0.0033048666,
0.023892961,
-0.0126580475,
-0.010706136,
0.017090648,
0.008023074,
-0.0059503918,
0.017025366,
0.0027238629,
-0.015132209,
0.0027679277,
-0.033737384,
0.0119007835,
-0.010281807,
-0.0025476033,
-0.015902529,
0.007951264,
-0.0056272494,
-0.000744615,
0.015536953,
0.004507675,
-0.0016826259,
-0.008212389,
0.024062693,
-0.017312605,
0.0013268427,
0.0018262448,
-0.008251558,
-0.008695471,
-0.012083571,
0.017717348,
0.008460458,
-0.013167242,
0.009961929,
0.013500176,
0.006945932,
0.0062180455,
-0.0023060625,
-0.0034468535,
0.021125033,
0.0012093363,
-0.0050331894,
0.004618653,
-0.0041551557,
0.017129818,
-0.009661634,
0.03130892,
0.0029294991,
-0.020393884,
-0.0039429916,
0.009576769,
-0.0058655264,
0.012135796,
0.0014941262,
0.029428817,
0.0031057587,
-0.030656105,
0.0051441677,
-0.005020133,
0.017652068,
-0.029820506,
0.011815918,
0.024349932,
-0.02205203,
0.0032983385,
0.0044456576,
0.05467963,
0.04363403,
0.0015675676,
0.0019274309,
-0.0010616374,
-0.0068610664,
-0.010784473,
0.004507675,
0.015602235,
-0.0030062045,
-0.029272143,
0.007344148,
-0.021673396,
-0.015785022,
0.013212938,
-0.030969456,
0.025733894,
-0.009929288,
0.0016304009,
0.026739227,
0.016437836,
0.01233164,
0.004618653,
-0.02718314,
0.03326736,
0.014518565,
-0.0059928247,
-0.004461978,
-0.033450145,
-0.008682415,
-0.022300098,
0.007435542,
-0.0005381628,
0.021595059,
0.011411174,
0.021007527,
0.009002293,
0.0031694078,
0.034102958,
-0.0016361129,
0.008473515,
-0.010751832,
0.01100643,
-0.0038646539,
0.009948872,
0.0003676154,
0.032718994,
0.015184434,
-0.008088355,
0.002730391,
-0.019793294,
-0.01121533,
-0.0058785826,
0.017430112,
0.017273435,
-0.036400862,
-0.016294217,
0.014688296,
0.0013113384,
0.008264614,
0.019493,
0.009061047,
-0.011828975,
-0.028854342,
-0.006152764,
0.022260929,
0.029141579,
0.024428269,
-0.023462106,
0.019806352,
-0.009354812,
0.014244383,
-0.040761653,
-0.018840188,
0.015824191,
-0.03151782,
0.0049842284,
-0.0012819618,
0.00929606,
0.0011815918,
0.004830817,
0.016685905,
0.008715056,
-0.034155183,
-0.013141129,
-0.016555341,
0.013682963,
-0.009302587,
-0.0004275926,
0.037236463,
0.023279317,
-0.017756518,
0.01575891,
0.009393982,
0.013030151,
-0.020485276,
0.0022864782,
0.032614544,
0.006345344,
0.017547617,
-0.005770868,
-0.018004587,
0.04154503,
0.017377887,
0.0017022103,
-0.0028625857,
0.03162227,
0.025642501,
0.025250813,
0.0063779843,
0.0029539794,
-0.01921882,
-0.008153636,
0.02309653,
-0.01201829,
0.0087542245,
-0.0018017644,
-0.021725621,
-0.024937462,
-0.030812781,
0.0077945893,
-0.018983807,
0.0029751959,
-0.0046349736,
-0.018526837,
-0.020002196,
-0.0031514554,
-0.016960086,
0.005405293,
-0.017808743,
-0.0014533253,
-0.0027042786,
0.0040996666,
-0.02613864,
-0.0013790678,
0.0015194226,
0.006146236,
-0.04248508,
-0.029272143,
0.0032950744,
0.030029405,
0.0067305034,
0.017103706,
-0.019414663,
-0.011939952,
0.017913193,
-0.021712566,
-0.03360682,
0.005963448,
-0.028514879,
-0.0024496813,
-0.0118812,
-0.006808841,
-0.0023076944,
-0.0020237209,
-0.017312605,
-0.0024888502,
-0.01840933,
0.047707584,
-0.024872182,
0.0087868655,
0.01921882,
0.018605174,
0.044704646,
0.031439483,
-0.016777297,
0.001989448,
-0.01711676,
-0.009968457,
-0.049483236,
0.012573182,
-0.026700059,
-0.01173758,
0.007409429,
-0.008643246,
-0.025812233,
0.016307272,
-0.01596781,
0.003721035,
0.02718314,
0.017247323,
0.019375494,
-0.0072201136,
0.017103706,
-0.018200431,
-0.0012738017,
0.004370584,
-0.009472319,
0.0068610664,
-0.0022163007,
-0.013878807,
0.007344148,
-0.00038005965,
-0.020093588,
-0.011515624,
0.015589179,
0.004755744,
0.045853596,
0.012299,
-0.0237624,
-0.010255694,
-0.003665546,
0.014831915,
-0.011156577,
-0.00018431772,
0.0021771318,
-0.009028406,
-0.0032640658,
0.016529229,
-0.004654558,
-0.01121533,
-0.02822764,
0.020211095,
0.036191963,
-0.000643837,
0.011744109,
-0.012181493,
0.010066379,
0.00080336817,
-0.0020171925,
-0.018435443,
-0.037262574,
-0.00023378871,
-0.028488766,
0.04206728,
0.02232621,
0.023253204,
0.01613754,
-0.008297255,
0.017077591,
0.011855087,
0.006407361,
0.014897197,
0.024558831,
-0.010680024,
0.019688845,
0.0018474612,
0.014218271,
0.009674691,
-0.03138726,
0.018814076,
0.01859212,
-0.019323269,
-0.022300098,
0.0055423835,
-0.019401606,
-0.03548692,
0.0022195647,
-0.020184983,
-0.00015167706,
-0.013983258,
0.0017299548,
0.014414115,
-0.014087708,
0.024689393,
-0.031047793,
0.024637168,
-0.013748245,
0.031073906,
0.007918623,
0.043137893,
-0.020589726,
-0.011639658,
-0.026869789,
0.008617134,
0.01565446,
0.011345892,
0.0005887559,
0.013813526,
0.0048340815,
0.008858674,
0.009883591,
-0.028619329,
-0.0111435205,
0.0058851107,
-0.013983258,
-0.012155381,
-0.011776749,
-0.0014916781,
-0.043503467,
-0.0025443393,
0.023253204,
-0.00061323633,
0.013017095,
-0.003717771,
-0.014335777,
0.030865006,
-0.006998157,
0.046558633,
-0.0008249926,
0.017286493,
0.024506606,
0.004974436,
-0.03577416,
-0.030551655,
-0.0008168325,
-6.470755e-7,
0.03491245,
0.015863359,
-0.010405841,
-0.018069869,
0.024362987,
0.0028038325,
-0.021190315,
-0.024741618,
0.0047296314,
-0.029924955,
-0.005672946,
-0.0111761615,
0.01726038,
-0.02263956,
0.0080948835,
0.00011648635,
0.0125927655,
-0.012827778,
0.01390492,
-0.04123168,
0.026269201,
0.0021722359,
-0.0013660116,
-0.0065281317,
-0.0137613015,
-0.005473838,
-0.014231327,
0.006074426,
0.00824503,
-0.0031873602,
0.041623365,
0.020772515,
-0.010183885,
0.019910801,
0.007938208,
0.011482984,
-0.0095376,
-0.019688845,
0.03441631,
-0.008956596,
-0.011117408,
0.016529229,
0.022156479,
0.01684258,
-0.0024464172,
0.005418349,
0.0008829298,
-0.016986199,
-0.0018964222,
0.0064302096,
0.010608214,
-0.0040017446,
-0.012899588,
0.00047859363,
-0.0024578415,
-0.041414466,
-0.03193562,
0.022260929,
-0.03277122,
-0.007853342,
-0.0021118505,
0.027444266,
0.024963574,
-0.007246226,
0.012227191,
0.00377326,
0.022273986,
-0.027444266,
0.015380278,
0.01002721,
0.007957792,
-0.0071809446,
0.018696569,
0.003223265,
-0.042850655,
0.009426622,
-0.03595695,
-0.017456224,
0.029272143,
-0.0005675394,
0.01191384,
0.009322172,
-0.023292374,
0.027313702,
0.0053269556,
0.012990981,
0.011835502,
-0.008799922,
-0.008728112,
-0.029115466,
0.010699607,
0.005806773,
-0.0024137767,
-0.013363086,
-0.011136993,
0.0023582876,
0.020002196,
-0.016189767,
-0.011652715,
-0.0062767984,
0.0037471475,
-0.0058459416,
0.0031955205,
0.015314996,
-0.008205862,
-0.021529777,
0.009119799,
-0.0127168,
0.007096079,
-0.025068026,
0.010294863,
0.0045598997,
0.010497236,
-0.009772613,
0.002229357,
0.020106645,
-0.01746928,
-0.040839992,
0.008512683,
-0.014296608,
0.03235342,
-0.00009251587,
-0.018278768,
-0.008950069,
-0.007637914,
-0.043660145,
-0.034155183,
0.0038026366,
0.01467524,
0.012808194,
0.0067239753,
0.0031171828,
0.016751185,
-0.010477651,
0.008271143,
0.0044032247,
-0.010262223,
-0.0033375074,
0.009387453,
-0.0051866006,
0.0054281414,
-0.04013495,
-0.00625395,
0.039221015,
-0.0114895115,
-0.02997718,
0.038620427,
-0.03378961,
0.020237207,
-0.0060417857,
-0.0058753183,
-0.007853342,
0.022822348,
0.028984904,
-0.03337181,
-0.023122642,
0.018370163,
0.0011138625,
-0.03989994,
0.010399314,
-0.029689942,
0.013526289,
0.016646735,
-0.0052910508,
-0.050527737,
0.007135248,
-0.018095981,
0.01212274,
0.029898843,
-0.01002721,
0.015680572,
-0.0006662774,
-0.015210547,
-0.032927897,
-0.028305978,
-0.019584395,
-0.014061595,
0.03491245,
-0.006887179,
-0.0038842382,
0.0023484954,
-0.015732797,
0.0014769897,
-0.011039071,
0.010967261,
-0.009909703,
-0.015863359,
-0.0031024946,
0.0035186629,
-0.0046839346,
-0.00024072485,
-0.010823642,
0.015210547,
-0.010125132,
0.0014631174,
-0.017142873,
0.0005903879,
-0.00008012261,
-0.00733762,
-0.008395177,
-0.00855838,
-0.0016100005,
-0.0031498235,
-0.03326736,
0.022417603,
0.16889583,
-0.017286493,
-0.001391308,
0.00083192874,
-0.0073833168,
-0.01002721,
0.018213486,
-0.014636071,
-0.013878807,
-0.01289306,
0.0062898546,
0.011835502,
-0.0049777003,
-0.0021036903,
0.00754652,
-0.03253621,
-0.014479396,
-0.02770539,
-0.029481042,
0.0084408745,
0.025511937,
-0.011039071,
-0.013813526,
-0.0065640365,
0.030342756,
0.017939305,
-0.028018741,
0.032901783,
0.012631934,
0.009850951,
-0.038698763,
0.0056794747,
0.0071221916,
-0.003228161,
0.022287041,
0.010196942,
0.020132758,
-0.0012770657,
0.00208737,
-0.011156577,
-0.0055782883,
0.015915584,
-0.010490707,
-0.019688845,
0.01498859,
-0.011574377,
-0.0017332189,
-0.0012754337,
-0.029846618,
-0.001243609,
-0.027313702,
-0.00006670934,
-0.018396275,
0.050710525,
0.004409753,
0.005405293,
0.0004210645,
0.017273435,
-0.008852147,
0.04050053,
-0.008081827,
0.010405841,
-0.024127975,
0.016568398,
-0.023697117,
0.026948128,
0.0016214247,
0.0010461331,
0.018579062,
-0.0151452655,
0.011626602,
-0.010112076,
-0.015850304,
0.009668163,
-0.0078011174,
-0.0074224854,
0.018500725,
0.024741618,
0.01855295,
0.018278768,
0.011352421,
-0.0034044206,
-0.031230582,
-0.023671005,
0.019166594,
-0.021373102,
0.01569363,
-0.008891315,
-0.01994997,
-0.013513233,
0.005953656,
-0.010758361,
-0.017443167,
0.0010241006,
0.0037863164,
-0.0018458292,
-0.019231876,
0.0021542835,
-0.012664575,
-0.029324368,
-0.024624113,
0.07348065,
0.009655107,
0.018774906,
-0.006074426,
0.019323269,
0.018579062,
-0.0041453633,
-0.012161909,
0.0017772838,
0.01191384,
-0.012560125,
0.022822348,
-0.0053334837,
0.024075748,
0.014544677,
0.019466888,
-0.05624638,
0.05561968,
0.0065216036,
-0.0075399918,
-0.0237624,
-0.02124254,
0.011992178,
-0.025812233,
0.011639658,
-0.0049972846,
-0.0039821602,
-0.042354517,
-0.01669896,
-0.0014500612,
0.005898167,
0.029324368,
0.005806773,
0.008538796,
-0.018383218,
0.02557722,
0.018709624,
-0.011665771,
0.0070112133,
0.0068218973,
-0.003570888,
0.008179748,
0.007344148,
-0.003122079,
0.0064595863,
0.03232731,
0.0059830328,
-0.009870535,
-0.0052029206,
-0.027679278,
-0.011659243,
0.00026622537,
0.01477969,
0.010921564,
-0.011783278,
-0.0027597677,
-0.04039608,
-0.017808743,
-0.004413017,
-0.050136052,
0.01310196,
0.037367024,
-0.009452734,
0.0024921142,
0.0077619483,
-0.16262881,
0.0016638575,
-0.005855734,
-0.04598416,
0.02197369,
0.019897744,
-0.0049483236,
-0.021699509,
0.0036981865,
-0.014048539,
0.010405841,
-0.0001537171,
-0.036975335,
-0.015027759,
0.0032183689,
0.0078011174,
-0.0064889626,
0.030865006,
0.02414103,
0.0062311017,
0.02176479,
-0.017208155,
0.0026961183,
-0.021999802,
-0.002185292,
0.0052747303,
-0.010288335,
-0.024793843,
-0.0068741227,
-0.018605174,
-0.01467524,
0.022469828,
-0.004253078,
-0.021020584,
0.009420094,
0.0036949224,
0.0024007205,
-0.014166046,
-0.005516271,
0.0075399918,
0.014087708,
0.018879356,
-0.017338717,
-0.017665124,
-0.014309664,
0.02239149,
0.016933974,
-0.017965417,
0.0030062045,
0.009798725,
-0.0050821505,
-0.00055897125,
-0.004351,
0.0042465497,
0.015106097,
-0.0057382276,
-0.008584493,
0.036949225,
-0.0024154086,
0.012174966,
-0.020876965,
-0.01613754,
0.021320878,
0.00445545,
-0.000118832395,
-0.02414103,
-0.0011097824,
0.008832562,
-0.013891864,
0.011221858,
-0.013957146,
-0.008127524,
-0.011026015,
-0.025864458,
0.008218918,
-0.0037340913,
-0.024075748,
0.018539894,
-0.010360145,
-0.022587335,
-0.0111435205,
0.029376592,
-0.023958243,
-0.02176479,
0.011750637,
0.0067305034,
0.013323916,
0.020067476,
-0.0018898941,
0.004915683,
0.01205093,
-0.02882823,
0.009165497,
0.0032559056,
0.016973142,
0.0023174868,
0.029402705,
-0.014087708,
-0.001787076,
-0.0071287197,
0.019858576,
-0.01680341,
0.012442619,
0.005424877,
0.036949225,
0.007096079,
-0.02361878,
0.008499627,
0.054940756,
-0.019297156,
-0.0051800725,
0.0019976082,
0.008512683,
0.041022778,
0.0087215835,
0.028906567,
-0.019049088,
-0.0038156928,
-0.0012933861,
-0.01534111,
0.06413236,
0.015941698,
-0.004253078,
0.009766085,
-0.004912419,
-0.0072592823,
-0.13620293,
-0.022169534,
0.017417055,
0.030943343,
0.0034631738,
0.009700803,
0.0026683738,
0.043346792,
-0.006018937,
0.028671553,
-0.026269201,
0.0014255807,
0.0029637718,
-0.00960941,
0.00008374369,
0.016359497,
-0.007833757,
-0.0083429525,
-0.022835404,
0.036453087,
-0.013957146,
0.0020155606,
0.023984356,
-0.019871632,
0.02382768,
0.0025116985,
-0.03112613,
-0.0052355616,
0.020511389,
0.0013203146,
-0.0048928345,
-0.019623563,
0.01855295,
-0.00237624,
-0.03350237,
0.0020057685,
0.0036786022,
-0.0084082335,
0.023840737,
0.015367222,
-0.00091149035,
0.007592217,
-0.0043477356,
-0.026425876,
0.009028406,
-0.00047247353,
0.009008821,
0.006440002,
-0.007298451,
-0.0026030925,
-0.034129072,
-0.015850304,
-0.040161066,
-0.01855295,
0.014596902,
-0.010190413,
0.01551084,
0.015053871,
-0.010634326,
-0.015980866,
-0.014949421,
-0.0008082643,
-0.0049777003,
-0.0056827385,
-0.007683611,
-0.010804058,
-0.015837247,
-0.02976828,
0.033841833,
-0.028358204,
-0.00901535,
0.012651519,
-0.0036492255,
-0.003079646,
-0.020093588,
0.0071613602,
-0.0502405,
-0.021190315,
-0.0031335033,
-0.012220662,
-0.00960941,
-0.021085866,
0.031700607,
-0.015497784,
0.0016573294,
0.026869789,
-0.00019206987,
-0.015811134,
0.006087483,
-0.002234253,
-0.034364086,
0.018148206,
-0.007690139,
-0.016960086,
-0.00922425,
0.01893158,
-0.015158322,
-0.0060711624,
0.015236659,
0.011842031,
-0.026817564,
-0.019923858,
-0.05334789,
0.008075299,
0.00030111006,
-0.01767818,
0.0006050762,
-0.02874989,
0.006384513,
0.01247526,
-0.013128073,
-0.0014778058,
-0.041623365,
0.0009172025,
-0.014531621,
-0.011117408,
-0.018278768,
-0.0047361595,
0.024650225,
-0.014949421,
0.017103706,
0.01799153,
-0.0150799835,
0.015941698,
0.01320641,
-0.0057937168,
-0.00504951,
-0.014270496,
-0.037158124,
0.0151452655,
-0.009968457,
-0.009028406,
0.0005765156,
-0.023435993,
-0.00803613,
0.005072358,
-0.0023533914,
-0.02316181,
0.012886532,
0.041205566,
0.016725073,
0.04381682,
-0.016437836,
-0.044077944,
0.010242638,
0.0061723483,
-0.0071026073,
0.006449794,
-0.04164948,
0.009994569,
0.010379729,
-0.009948872,
0.023879904,
0.008055714,
0.004612125,
-0.022260929,
-0.017025366,
0.0027581356,
0.0061560282,
-0.018709624,
0.008512683,
-0.021999802,
0.010973789,
0.029898843,
0.015027759,
0.004811233,
-0.0058851107,
0.0008074483,
-0.011345892,
-0.027522603,
0.0122467745,
-0.041388355,
-0.018840188,
0.0013684595,
0.02205203,
-0.0036329052,
-0.0015561434,
-0.000069310394,
-0.024598,
0.0025590276,
0.0071091354,
0.02620392,
0.00006247626,
-0.00960941,
-0.0010771417,
0.021947578,
0.019558283,
0.0065934127,
-0.0064661144,
0.024924407,
-0.012827778,
0.014048539,
0.025420545,
0.014844971,
-0.0024137767,
0.030447206,
-0.014257439,
0.0005867158,
-0.014492452,
0.0151452655,
0.006632582,
0.030342756,
0.0035349831,
-0.003962576,
0.002178764,
-0.020433052,
0.005029925,
0.011261027,
-0.027731502,
-0.033032347,
-0.002483954,
-0.0006548532,
0.004514203,
-0.00055611524,
-0.0028625857,
0.0062963828,
-0.013461007,
0.013826583,
-0.0057186433,
-0.013957146,
-0.023279317,
0.008369065,
0.022456773,
0.023266261,
0.02330543,
-0.0012509532,
-0.014152989,
0.015132209,
0.027522603,
-0.0061397078,
0.011476455,
-0.0019437511,
0.016189767,
-0.004830817,
-0.010399314,
0.0050331894,
-0.012096628,
0.021595059,
0.009576769,
0.01911437,
-0.0045860126,
0.066012464,
0.022874573,
-0.008604078,
0.0053367475,
-0.023932131,
0.023527386,
0.020981414,
0.012174966,
0.00082703267,
-0.018370163,
-0.00026663337,
-0.021307822,
0.040787768,
-0.027235365,
-0.008950069,
0.024963574,
0.0026259408,
0.030891119,
-0.044208508,
-0.0032493775,
0.023684062,
-0.020850852,
0.02138616,
0.00625395,
-0.038829327,
0.010425426,
0.047289785,
0.0033424033,
0.012044403,
-0.018918525,
0.01569363,
-0.018748794,
-0.020224152,
0.0009180185,
0.006391041,
-0.014505508,
-0.001186488,
0.010320976,
0.033241246,
0.030760556,
0.021647284,
-0.013271691,
-0.005904695,
-0.025564164,
0.02103364,
0.02026332,
-0.025381375,
-0.00863019,
-0.013682963
] |
Intestinal microbiota metabolism of choline and phosphatidylcholine produces trimethylamine (TMA), which is further metabolized to a proatherogenic species, trimethylamine-N-oxide (TMAO). We demonstrate here that metabolism by intestinal microbiota of dietary L-carnitine, a trimethylamine abundant in red meat, also produces TMAO and accelerates atherosclerosis in mice. Omnivorous human subjects produced more TMAO than did vegans or vegetarians following ingestion of L-carnitine through a microbiota-dependent mechanism. The presence of specific bacterial taxa in human feces
|
[
0.022302197,
-0.018498411,
-0.0032982829,
-0.016629886,
-0.030884072,
0.018445026,
-0.039319135,
-0.005832472,
-0.02099423,
-0.00017215051,
0.024531083,
0.015268531,
-0.013146418,
0.0023790346,
-0.016589845,
-0.0061361073,
0.046766546,
0.0026392937,
-0.004411057,
0.00726056,
-0.029442638,
0.027494032,
0.0041374513,
-0.010643927,
0.025812358,
0.014254187,
0.015241837,
-0.04631276,
-0.03739722,
-0.009956577,
0.02248905,
-0.005995968,
-0.02912232,
-0.0025492038,
-0.0044844635,
0.001728387,
0.009302592,
0.011971916,
0.009022313,
-0.00033408252,
-0.0063763466,
0.010236856,
0.012278888,
0.0058658384,
-0.016856778,
-0.005792432,
0.0042375512,
-0.019512754,
-0.03638288,
0.007520819,
0.04052033,
0.0038371524,
0.008021317,
-0.0059993044,
-0.017190443,
0.013146418,
-0.009856477,
0.022355584,
-0.008695321,
-0.009369326,
0.007734365,
-0.010817434,
-0.037210368,
0.00624288,
0.0051117544,
0.0019185762,
-0.0072071734,
0.03216535,
0.0056122527,
0.018004587,
0.011471418,
0.029175706,
-0.0068935277,
-0.005548856,
0.024998214,
-0.012158768,
-0.042068537,
-0.005105081,
0.008728688,
-0.00361026,
0.035955787,
-0.01929921,
-0.0037003497,
0.044497624,
0.018445026,
-0.020233473,
0.004751396,
0.0070403405,
0.013706976,
-0.011104385,
0.005945918,
0.018151399,
0.029629491,
0.016870124,
-0.010917533,
0.0039138957,
-0.029816343,
0.039399214,
-0.012779386,
-0.0069535878,
-0.010997613,
-0.0032198715,
-0.015121718,
-0.01720379,
-0.040707182,
-0.0071137473,
-0.0024207428,
-0.004788099,
0.011704983,
-0.008708668,
-0.0027060267,
0.030563753,
0.014721319,
-0.040493637,
-0.008788748,
0.01357351,
0.03149802,
-0.009155779,
0.00019832239,
-0.023062956,
0.03448766,
0.018992236,
0.0014063998,
0.011444724,
-0.00541539,
0.01254582,
-0.004257571,
-0.0026860067,
-0.0070536872,
-0.005685659,
0.009956577,
-0.003263248,
0.008134764,
0.010143429,
-0.018244825,
0.02166156,
-0.04190838,
0.004451097,
-0.0075942255,
-0.026186064,
0.0034934771,
0.012966239,
-0.010603888,
0.008361656,
-0.023797018,
0.04532511,
0.020326898,
0.025825705,
-0.0028895426,
-0.0035368537,
0.016042635,
-0.018404985,
0.0148280915,
-0.007694325,
0.008928887,
0.023797018,
0.006966934,
0.03616933,
-0.027360566,
-0.0013129734,
-0.0038438258,
-0.028107977,
0.007607572,
0.0065198224,
0.025652198,
0.023676898,
0.0088688275,
0.025385266,
0.0032048565,
-0.037584074,
0.010116736,
0.03149802,
-0.009416038,
0.02083407,
-0.018084666,
0.03267252,
-0.008701994,
0.013106379,
-0.007680978,
-0.026586462,
0.023823712,
0.027253794,
0.03705021,
-0.010623908,
0.008354982,
-0.0049649416,
0.01000329,
-0.01363357,
-0.0013379984,
-0.033206385,
-0.004671316,
0.012799406,
-0.008194823,
-0.03176495,
-0.6393564,
-0.016429687,
-0.004751396,
-0.016950205,
0.017524108,
0.0009492782,
0.011838449,
-0.0057957685,
0.0033166343,
0.009429385,
0.0044444236,
0.015655583,
0.019739646,
-0.028107977,
0.0045712166,
-0.028988853,
0.010483768,
-0.02446435,
0.009889844,
0.0030830686,
-0.01432092,
-0.021514747,
0.01893885,
-0.0029245776,
0.0032081932,
0.0061127506,
0.019472715,
0.0005638946,
-0.021835066,
0.021047616,
-0.021247815,
0.023917139,
-0.0036669832,
-0.005148458,
0.055842247,
-0.017590841,
-0.0021488054,
0.02462451,
-0.0054554297,
0.016910164,
0.010190142,
-0.028188055,
0.024557777,
0.009989943,
-0.0015682275,
0.029415945,
0.03149802,
0.013173112,
0.010543828,
-0.013326597,
-0.0033733575,
0.004858169,
0.0017300553,
0.006710012,
0.010630581,
0.0004696341,
0.044924714,
-0.026706582,
-0.005542183,
0.039933078,
-0.012005283,
0.0148280915,
-0.0076008984,
-0.020353591,
-0.021981878,
0.023730285,
-0.020220125,
0.00015160923,
-0.0050149914,
-0.016082674,
0.011444724,
0.026172716,
-0.014200801,
-0.025705585,
0.022315545,
0.032805987,
0.0009884839,
0.02553208,
-0.0069268947,
0.01248576,
0.0013396668,
0.018244825,
-0.004110758,
-0.0034234074,
0.024317537,
0.012065342,
-0.0066933287,
-0.0051884977,
-0.010570521,
-0.016523112,
0.006966934,
0.027707579,
-0.024477696,
-0.0307773,
-0.00722052,
0.00881544,
-0.009556178,
0.008401696,
-0.0030480337,
-0.01353347,
-0.02623945,
-0.00112195,
0.022782676,
0.020073313,
0.022729289,
-0.0053519937,
-0.043670133,
0.0046779895,
0.02591913,
-0.0036236066,
0.005268577,
0.0087353615,
0.00057390454,
-0.016896818,
-0.005945918,
-0.009496118,
0.01333327,
-0.0010627244,
-0.006159464,
-0.054934677,
0.022475705,
0.012699306,
0.007520819,
0.015041638,
0.020340245,
0.020447018,
0.018525105,
-0.009929883,
-0.010323608,
-0.01339333,
-0.0011444724,
0.024677895,
0.029282479,
-0.017550802,
0.014254187,
0.03400718,
0.035448615,
-0.0023189748,
0.001871863,
-0.020326898,
-0.007133767,
-0.013093032,
0.00057307037,
-0.0055555296,
-0.029762957,
-0.029229091,
0.006696665,
0.013947215,
-0.009929883,
0.005885858,
0.009816437,
0.0029479342,
-0.03227212,
0.009843131,
0.02186176,
-0.006593229,
-0.022755982,
-0.028268136,
-0.008281576,
0.015855782,
-0.016029287,
0.021448014,
0.0099832695,
0.0077276914,
-0.025705585,
-0.004084065,
0.0055922326,
-0.0023990546,
-0.017470723,
-0.011951895,
0.005732372,
-0.035048217,
-0.010423708,
-0.0011302916,
-0.013827096,
0.025038254,
-0.008101397,
-0.015829088,
-0.024798015,
0.002197187,
-0.002212202,
0.008001297,
-0.0036736564,
0.015949208,
0.03002989,
-0.011584864,
0.01976634,
0.0010343628,
0.00356021,
0.048741847,
-0.0033850358,
0.027000207,
0.007560859,
-0.014948212,
0.010784067,
-0.018218134,
0.00638302,
0.013313251,
0.006816785,
0.008448409,
0.003436754,
-0.014921518,
0.0007857821,
-0.04652631,
0.023543432,
0.007680978,
-0.021488054,
-0.016990244,
0.02864184,
0.026773315,
-0.016015941,
-0.0060994043,
-0.01803128,
-0.022075305,
-0.00021521421,
0.0018384965,
-0.004190838,
-0.023009568,
0.014214148,
-0.02371694,
0.017684268,
-0.010590541,
0.007867831,
-0.019152395,
-0.0071537867,
0.025932478,
0.013032972,
0.017751,
-0.035955787,
-0.010577194,
0.012158768,
0.005982621,
0.02063387,
0.00074198854,
0.04009324,
0.008174803,
-0.004391037,
0.004267581,
0.0292024,
0.02264921,
-0.013133071,
0.01897889,
0.013466737,
-0.024944829,
0.012792733,
-0.005528836,
0.020593831,
0.02813467,
0.0064697727,
0.0068801814,
-0.006286257,
0.008368329,
-0.013026299,
-0.02623945,
-0.011538151,
-0.0037403896,
0.0060560275,
0.016362952,
0.03977292,
0.0051551308,
0.015335264,
0.0009976596,
-0.006349653,
-0.015842434,
-0.014587853,
0.00538536,
0.0037503995,
0.01163825,
-0.0010894176,
-0.01807132,
-0.024811361,
0.00818815,
-0.0024390942,
-0.04924902,
0.009662951,
0.007801098,
0.022262158,
0.0048248023,
0.00816813,
0.015201797,
-0.019899806,
-0.036035866,
0.032645825,
0.02450439,
-0.016202794,
-0.002340663,
-0.032005187,
-0.02020678,
-0.006980281,
0.0071137473,
-0.010977593,
0.022635862,
0.0031097617,
0.008655282,
-0.03739722,
-0.017297216,
0.016002594,
-0.0217016,
0.025398612,
-0.008508469,
-0.0014389321,
0.0045912364,
-0.022182077,
-0.0012162105,
0.021768333,
0.005532173,
-0.03555539,
-0.0037303795,
0.0061928304,
-0.021261161,
0.018004587,
-0.014881479,
-0.0056456192,
-0.021327894,
-0.008748707,
0.013239845,
-0.013500104,
-0.01605598,
0.01169831,
-0.010370322,
-0.005568876,
-0.030430287,
-0.0067967647,
0.015375303,
0.018805385,
0.0046212664,
-0.0046946728,
0.015642235,
0.015682276,
0.020473711,
-0.0065131495,
-0.03467451,
0.030430287,
0.006363,
0.0070136474,
-0.002819473,
0.011044326,
-0.0034000508,
0.022982875,
0.010163449,
-0.010784067,
-0.020193432,
-0.011538151,
-0.007807771,
0.01913905,
-0.023983872,
0.0075341654,
0.018885463,
0.028908772,
0.009249206,
0.019352594,
0.03886535,
0.0065098125,
-0.014067335,
0.0073006,
-0.00007507472,
-0.006746715,
-0.0008333294,
0.00077994296,
-0.0055455193,
0.007907871,
0.02020678,
-0.00996325,
0.008114743,
0.014214148,
0.030323515,
-0.0032415597,
-0.00315147,
-0.0054187267,
-0.005028338,
-0.009229186,
0.0030497022,
-0.0010468753,
-0.033633474,
0.013947215,
0.030910766,
-0.019686261,
-0.018778691,
0.008768728,
-0.013433371,
0.0072939266,
0.007994624,
-0.0070536872,
-0.008321616,
0.016229486,
-0.03227212,
0.013853789,
-0.0023907127,
0.010617234,
0.0022005236,
-0.022849409,
-0.012112055,
-0.03240559,
0.004013995,
0.0036803298,
-0.019312555,
-0.028721921,
-0.010657274,
-0.014574506,
0.013059665,
0.011871817,
-0.042442244,
-0.0018218133,
0.049622722,
-0.0067600617,
0.002861181,
0.0020019927,
-0.018004587,
0.011511457,
0.009676297,
0.01077072,
-0.037690848,
-0.010597214,
-0.0060693743,
-0.005205181,
-0.0047947722,
0.017884467,
-0.004344324,
-0.020660564,
-0.0060593644,
-0.0042242045,
0.013893829,
-0.0011911856,
-0.006806775,
-0.008655282,
-0.013406677,
-0.002916236,
-0.0051584677,
-0.013540143,
-0.028908772,
-0.008528489,
-0.027413951,
0.011958569,
-0.007680978,
0.025718931,
0.020019926,
-0.02805459,
-0.0037604095,
0.022449011,
0.016790045,
0.006533169,
0.023650207,
-0.01077072,
0.0036469633,
-0.021674907,
0.0031581433,
0.029522717,
-0.0013238176,
-0.01893885,
0.01002331,
0.011037652,
0.011471418,
-0.039986465,
0.01353347,
0.011518131,
-0.0005955928,
-0.0146946255,
-0.038811963,
-0.02611933,
-0.025305187,
-0.0099165365,
0.0015039969,
-0.020019926,
-0.0114847645,
-0.016109368,
0.0060293344,
-0.023102995,
-0.013893829,
0.027520726,
-0.031791642,
-0.017777694,
-0.00030822345,
-0.010290242,
0.020233473,
0.0023106332,
-0.009382672,
-0.042629097,
0.008261556,
-0.01546873,
-0.023049608,
-0.0042408877,
-0.0146012,
0.030750606,
0.0051884977,
0.027867736,
-0.029149013,
0.019112356,
0.024491044,
0.012806079,
-0.013066338,
-0.011711657,
0.022622516,
-0.019312555,
0.004344324,
0.01593586,
0.0023289847,
0.0118117565,
-0.0064430796,
-0.0033800309,
0.019339249,
-0.012712653,
-0.0048781885,
0.013006278,
-0.029335866,
-0.0048248023,
0.0019002246,
-0.023383273,
0.016242834,
-0.023129689,
-0.028268136,
0.05578886,
0.020153392,
0.034194034,
0.012392335,
0.028107977,
-0.01823148,
0.028107977,
0.0019285862,
0.017897815,
0.030190049,
-0.029255785,
0.010483768,
-0.006846815,
0.018338252,
-0.018218134,
0.011765043,
0.021915145,
-0.027921123,
0.010643927,
0.0068301316,
0.0009876497,
-0.0060994043,
-0.008361656,
-0.010223509,
-0.023823712,
-0.015829088,
0.018551799,
-0.055254996,
-0.0061160875,
-0.0011786731,
-0.01885877,
0.0118117565,
-0.028588455,
-0.015201797,
0.030163355,
0.0070803803,
0.019659568,
-0.029415945,
0.013146418,
-0.015482076,
0.0065131495,
-0.008581875,
0.017417336,
-0.004818129,
-0.009696318,
0.03424742,
0.01704363,
-0.0035101604,
-0.019379288,
-0.0024791341,
0.01621614,
-0.03830479,
-0.03398049,
0.00624288,
-0.0040473617,
0.013760363,
-0.014227495,
-0.014454386,
-0.011211159,
0.0023623512,
-0.0054320735,
-0.0035001505,
-0.021434668,
-0.008141437,
-0.014067335,
0.036543038,
0.015602196,
-0.0037470628,
-0.011438051,
0.003987302,
0.0063563264,
-0.03219204,
-0.015361956,
0.023369927,
0.022395624,
0.024437657,
0.0073139463,
0.020580484,
-0.010397015,
0.03219204,
0.005268577,
-0.018338252,
-0.0032832678,
0.036115948,
-0.010683967,
0.00728058,
0.0050617047,
-0.0023690246,
0.0059759477,
-0.018618532,
0.009576198,
-0.026960168,
-0.027520726,
-0.004064045,
0.025145028,
0.0076876516,
-0.017390642,
0.013506777,
-0.026973514,
-0.021274509,
-0.024704589,
-0.010924206,
0.026559768,
-0.016015941,
0.003967282,
-0.0015840767,
0.0061260974,
0.006786755,
0.01452112,
-0.022502396,
-0.033446625,
0.028508374,
-0.022195425,
0.017417336,
0.0049082185,
0.0135134505,
-0.009996616,
-0.012879486,
-0.004034015,
0.0108508,
0.010236856,
-0.02055379,
-0.05488129,
-0.015401997,
0.019472715,
0.0075942255,
0.0011244526,
-0.005065041,
0.018618532,
-0.010483768,
0.0139071755,
0.007680978,
0.0046779895,
0.016576499,
-0.044551007,
0.0057590655,
0.010670621,
0.017550802,
0.0068668346,
-0.005805779,
-0.01909901,
0.005779085,
0.0066933287,
0.006873508,
-0.0012020298,
0.009876497,
-0.01869861,
-0.006476446,
-0.010110063,
-0.012512454,
-0.018738652,
-0.014841438,
-0.0008958917,
-0.009682971,
-0.0089756,
0.0031498016,
-0.010663947,
-0.013733669,
0.00049716147,
0.010350302,
0.0031598117,
0.00986315,
-0.019459369,
-0.012779386,
-0.022235464,
0.015642235,
-0.017377296,
-0.027627498,
-0.008141437,
-0.002697685,
-0.04714025,
-0.030964153,
-0.010677294,
-0.0036836665,
0.00028924624,
-0.00059851236,
-0.0116182305,
0.0076409383,
-0.016830085,
0.0048014456,
-0.02186176,
0.0049882983,
0.010457074,
-0.010477095,
0.010737354,
0.0034968138,
-0.017991241,
-0.018912157,
0.014013948,
0.0012345621,
-0.013867135,
0.014948212,
0.005722362,
0.010517134,
-0.02142132,
0.012659267,
0.012445721,
-0.0043076207,
0.020153392,
-0.032458972,
0.0026659868,
-0.004971615,
-0.021594826,
0.003763746,
-0.012085362,
-0.017190443,
0.010717334,
0.008114743,
0.0033566742,
-0.008828787,
0.022822715,
-0.0036069234,
0.012532474,
-0.0007916212,
0.0015223485,
0.020113353,
0.01562889,
-0.032939453,
-0.024424309,
-0.008588549,
-0.019392636,
-0.012812752,
-0.0024457676,
-0.0059125517,
-0.010263549,
0.008575202,
0.014414347,
-0.020366939,
0.014174107,
-0.017390642,
-0.0102435285,
-0.0015698959,
0.011211159,
0.0045144935,
0.0066766455,
-0.020380285,
0.0016800055,
-0.020059966,
0.021007575,
-0.025198413,
-0.016736658,
-0.017297216,
-0.002861181,
0.029255785,
-0.019339249,
-0.00059684407,
0.013680283,
-0.033606783,
-0.018445026,
0.015295223,
0.17371957,
-0.008575202,
-0.014360961,
0.035341844,
-0.0035468636,
0.0055788863,
0.008788748,
0.0017734318,
-0.016082674,
0.019739646,
0.040146627,
0.006689992,
-0.0059025413,
-0.0011152767,
0.002060384,
0.013326597,
-0.03390041,
-0.00818815,
0.006913548,
-0.023650207,
0.008428389,
-0.012859466,
0.01353347,
-0.0041274414,
0.01248576,
-0.0030163354,
-0.006793428,
-0.0037770928,
0.015775701,
-0.02280937,
-0.02051375,
-0.002834488,
-0.0016174432,
0.004904882,
0.0060593644,
0.014641239,
-0.007006974,
0.0007861992,
0.014547813,
-0.005191834,
0.008054684,
0.0068401415,
-0.0044344137,
-0.016696619,
-0.021568134,
0.017083671,
0.0018368282,
0.0034434274,
-0.011017633,
0.0013171443,
-0.038651805,
0.008435062,
0.01851176,
0.02446435,
-0.01165827,
-0.0054887966,
0.0044677802,
0.009082373,
0.0163763,
0.051037464,
-0.010777393,
0.019325903,
-0.019939847,
0.027026901,
-0.015815742,
0.010510461,
-0.012005283,
-0.013947215,
0.0017250503,
-0.016856778,
0.018778691,
-0.012225501,
-0.007694325,
-0.02738726,
0.0033950459,
-0.012358968,
0.020473711,
0.0035702202,
0.0009325949,
0.027333872,
-0.025585465,
-0.012919526,
-0.0183516,
-0.0025158373,
-0.015922515,
-0.01901893,
0.014707972,
0.012365641,
-0.017924508,
-0.00362027,
0.011197812,
-0.011044326,
-0.00014493593,
-0.0045778896,
0.0061661373,
-0.018138053,
0.01077072,
-0.03184503,
0.0022155384,
-0.0069869542,
-0.0434032,
0.05173149,
-0.0015740667,
0.01163825,
-0.023423314,
0.017937854,
-0.030190049,
0.013159765,
0.0065965657,
0.0045612063,
-0.010283569,
-0.015281877,
-0.011651597,
-0.020860763,
0.0014614546,
0.022582477,
0.027627498,
-0.0035902401,
0.031684868,
-0.010543828,
-0.0034501005,
-0.012612553,
-0.00724054,
0.025331879,
-0.01925917,
0.000088473476,
-0.027467338,
-0.0021287855,
-0.012679286,
-0.015909167,
0.0013688625,
0.002157147,
-0.010483768,
0.02978965,
-0.020366939,
0.008328289,
0.000115844465,
-0.0146946255,
0.0053052804,
0.03069722,
-0.012352294,
0.0049582683,
0.006486456,
-0.03558208,
0.02406395,
-0.027841045,
-0.007227193,
-0.014094028,
-0.033286463,
-0.00903566,
-0.006586556,
-0.00820817,
-0.012065342,
0.016309567,
0.012719327,
-0.008715341,
-0.011371318,
-0.038918737,
-0.012732673,
0.0062695737,
-0.0146012,
0.013706976,
0.026813354,
-0.007147114,
0.0078211175,
0.025478693,
-0.16763352,
0.022996223,
0.015255184,
-0.01448108,
0.041187663,
0.006189494,
0.017684268,
0.0052752504,
0.008261556,
-0.002764418,
0.04620599,
0.00046337786,
-0.036329493,
-0.012812752,
0.023236461,
0.005872512,
-0.0037804295,
0.008121417,
-0.007093727,
0.0056756493,
0.013213151,
-0.009496118,
0.015041638,
-0.035021525,
0.012198809,
0.03648965,
0.006546516,
0.025438653,
-0.0043176305,
-0.021488054,
-0.020727297,
-0.011951895,
0.026212757,
0.027013553,
0.039025508,
0.011458071,
0.0073206197,
-0.030056583,
-0.02095419,
0.013706976,
-0.0019969877,
0.03400718,
0.0026142686,
-0.015135064,
-0.012692633,
0.0036269433,
-0.016202794,
-0.0093893455,
0.016990244,
0.0018585165,
0.011044326,
-0.00042062698,
0.008481775,
0.021634867,
0.0037770928,
0.034274112,
0.007133767,
0.013433371,
-0.0070136474,
-0.0070603606,
0.0063463165,
-0.012779386,
0.027213752,
0.0059926314,
0.008368329,
-0.03523507,
-0.0044043837,
-0.01424084,
-0.009069026,
0.010824107,
-0.027867736,
-0.005792432,
-0.002819473,
-0.015121718,
0.018645225,
0.006873508,
0.0056756493,
0.010523808,
0.00358023,
0.033126306,
-0.013867135,
0.0056923325,
-0.06262233,
-0.0072338665,
-0.030884072,
0.011304585,
0.0057490557,
0.003339991,
-0.019352594,
-0.002962949,
0.010316935,
-0.036089253,
0.0008500127,
-0.03184503,
0.02111435,
0.025038254,
0.017804388,
0.015722316,
0.0053987065,
-0.008688648,
0.009549505,
-0.006593229,
-0.021234468,
0.022395624,
0.004641286,
0.022235464,
-0.030563753,
-0.014948212,
0.04011993,
-0.017977893,
-0.0034334173,
-0.0062128506,
0.004334314,
0.030857379,
-0.021367934,
0.015495423,
-0.0048715156,
-0.030723913,
-0.012372314,
-0.0050250012,
0.04956934,
-0.006042681,
0.011584864,
0.021995226,
-0.003513497,
-0.03283268,
-0.14019287,
-0.018431678,
-0.022715943,
0.012799406,
-0.008808767,
0.0020170074,
-0.0040773917,
-0.0020103343,
0.0054554297,
0.03763746,
0.017177097,
-0.01538865,
0.0076209186,
-0.010957573,
0.006853488,
0.014307573,
0.0050617047,
-0.006913548,
-0.02055379,
0.033713557,
-0.006089394,
-0.019779688,
-0.007267233,
-0.02888208,
0.0051017446,
-0.006806775,
-0.011598211,
0.020620523,
-0.010230183,
0.017871121,
0.025104987,
-0.009689644,
-0.004804782,
-0.008715341,
0.004257571,
0.012932872,
0.043109573,
-0.0057390453,
0.031951804,
0.0041007483,
-0.0059726113,
0.009155779,
0.020166738,
0.009189146,
0.03929244,
-0.012712653,
-0.013827096,
0.011725004,
-0.0019119029,
-0.0031548068,
-0.0119452225,
-0.0060727107,
-0.04644623,
0.009889844,
0.03547531,
-0.01452112,
0.020353591,
0.027787657,
-0.027053593,
-0.026252797,
-0.009309266,
-0.008468429,
0.0010468753,
0.012532474,
0.024891442,
-0.01593586,
-0.003401719,
-0.016082674,
0.014961558,
-0.023143034,
0.012639247,
0.004544523,
-0.006763398,
-0.0126659395,
-0.021728294,
0.0060860575,
-0.019058969,
-0.026679888,
0.002794448,
-0.017390642,
0.0011027643,
-0.02706694,
0.0077944244,
-0.0027393932,
-0.012732673,
0.015268531,
0.005462103,
0.0048815254,
-0.02099423,
-0.029816343,
-0.023917139,
0.036863357,
-0.0011403016,
-0.016576499,
-0.012132076,
0.0066632987,
0.0056756493,
0.0012228838,
0.050556988,
-0.014267534,
-0.0039072223,
-0.031631485,
-0.04623268,
0.008535162,
0.0013455058,
-0.016563153,
0.015562156,
-0.002197187,
0.011064346,
-0.009669624,
0.016896818,
0.026746621,
-0.01909901,
0.033526704,
-0.022662556,
0.010463748,
-0.013026299,
0.0021855086,
0.020527098,
0.016803391,
0.016896818,
0.009342632,
0.015268531,
0.022449011,
0.0008016312,
0.013359964,
0.0048381486,
0.01901893,
-0.019112356,
0.030216742,
-0.012132076,
0.0045311768,
0.02154144,
-0.022876102,
0.010116736,
-0.010430382,
-0.024771322,
-0.00091507746,
-0.026586462,
0.017297216,
-0.0064831194,
0.039265748,
-0.0032749262,
-0.020527098,
0.014360961,
-0.0066632987,
0.011050999,
-0.027440645,
-0.028668534,
-0.0021805037,
0.00903566,
-0.01177839,
0.018445026,
0.006886855,
-0.0039772918,
-0.036356185,
-0.012679286,
0.016669925,
0.009776398,
0.004067382,
0.0039072223,
-0.025772318,
0.013026299,
0.013620223,
0.010617234,
0.010230183,
0.003743726,
-0.008294922,
-0.0059626014,
-0.0026042587,
0.026853394,
-0.051891647,
-0.042095233,
-0.01444104,
-0.0016433023,
0.00031010032,
0.009109067,
-0.0037103596,
0.003553537,
0.014974904,
-0.011498111,
0.023450008,
-0.007974604,
-0.00025066617,
-0.024277497,
0.038331486,
0.02351674,
-0.009028987,
-0.0055355094,
-0.0056623025,
0.004130778,
-0.0011094376,
-0.008968927,
0.01881873,
0.022248812,
-0.013159765,
-0.0035869034,
0.02311634,
-0.002605927,
-0.0014047315,
0.018084666,
0.01819144,
0.018658571,
-0.0016966887,
-0.006012651,
-0.0047247023,
0.0018017933,
0.00903566,
-0.033820327,
-0.019699607,
-0.014374307,
0.0069202213,
0.021634867,
0.020473711,
0.0017700951,
0.0052952706,
-0.013867135,
0.027627498,
-0.02450439,
0.009469425,
-0.004140788,
0.008314943,
0.012225501,
0.021394627,
-0.00028882915,
0.014707972,
0.032485668,
0.0123389475,
0.032645825,
-0.02954941,
0.030296821,
0.014174107,
0.0077744047,
0.010090043,
-0.026546422,
-0.022168731,
-0.025959171,
0.0077076717,
0.0035568736,
0.009342632,
-0.025425306,
0.073086075,
0.0039606085,
-0.0001715249,
0.012979586,
0.024451002,
0.020967536,
0.025932478,
0.027680885,
0.005822462,
-0.00015087934,
0.009649605,
-0.013933868,
0.031711563,
-0.042121924,
-0.009335958,
0.014307573,
-0.018138053,
0.0051718145,
0.014360961,
-0.023663552,
0.010590541,
-0.008962254,
0.0006760896,
0.013166438,
-0.035021525,
0.00034805475,
0.027467338,
-0.012699306,
-0.00017246332,
-0.04060041,
0.00360025,
0.022422317,
-0.040653795,
0.008281576,
-0.0062228604,
-0.015175104,
-0.0055154897,
-0.033820327,
0.029736264,
0.008988947,
-0.0046946728,
-0.002355678,
-0.022275504,
-0.027040247,
-0.0025425307,
-0.02359682,
-0.0052952706,
-0.0012704311,
-0.031658176
] |
CONTEXT Use of antiretroviral drugs, including protease inhibitors, for treatment of human immunodeficiency virus (HIV) infection has been anecdotally associated with hepatotoxicity, particularly in persons coinfected with hepatitis C or B virus. OBJECTIVES To ascertain if incidence of severe hepatotoxicity during antiretroviral therapy is similar for all antiretroviral drug combinations, and to define the role of chronic viral hepatitis in its development. DESIGN Prospective cohort study. SETTING University-based urban HIV clinic. PATIENTS A total of 298 patients who were prescribed new antiretroviral
|
[
-0.017635843,
-0.024669493,
0.0072405217,
-0.041038245,
0.00031192426,
0.020247603,
0.009600156,
0.017416041,
-0.02212238,
-0.006535864,
0.0025551931,
0.0007353655,
0.013110517,
-0.003267932,
-0.009897535,
0.0078029553,
0.044632643,
-0.010026829,
0.0078029553,
-0.005317258,
-0.031418692,
0.00076486095,
-0.0166532,
-0.02991887,
0.0034392478,
0.0018521514,
0.016549764,
-0.04683066,
-0.02653134,
-0.00729224,
0.0010278955,
-0.0029026736,
0.0018618484,
-0.007628407,
0.002304684,
-0.009005399,
-0.00014485084,
0.017752208,
-0.008255488,
0.017519478,
0.005753629,
-0.0056404956,
-0.0048647257,
0.033927016,
-0.0050812946,
0.0061964644,
0.013291529,
-0.019678704,
-0.029815434,
0.011830496,
0.031935874,
0.0051491745,
0.01640754,
0.002364483,
0.034185607,
-0.01773928,
-0.024281606,
0.018553836,
-0.011035331,
-0.011882214,
-0.016769566,
0.005226752,
-0.011494328,
0.014765493,
-0.017247958,
0.034263182,
-0.00950965,
0.012651519,
-0.0117012,
0.024488479,
0.04685652,
0.02968614,
-0.0016008341,
0.006131817,
0.018540908,
-0.0015458837,
-0.04450335,
-0.018993441,
0.0023628667,
0.025173742,
0.020945795,
-0.006597279,
-0.0038820833,
0.029841293,
0.018140092,
-0.007363352,
0.015773993,
0.03661635,
0.029349972,
-0.010052688,
-0.018618485,
0.000069950634,
0.000550716,
0.03203931,
0.0058085793,
0.035607852,
0.017545335,
0.03480622,
-0.017390182,
-0.0023095326,
-0.00017646751,
0.00041091576,
-0.035866443,
-0.007964574,
-0.0063289916,
0.039745294,
-0.014468114,
0.014519832,
0.011261597,
-0.006219091,
-0.010783206,
0.060665227,
0.009167017,
-0.022510266,
0.022820573,
0.018838286,
0.015024083,
0.0072728456,
0.014998224,
-0.026156384,
-0.0003664706,
0.018140092,
0.032091025,
-0.02313088,
0.021359539,
-0.0066005113,
-0.03765071,
-0.009063582,
0.010757347,
-0.00806801,
0.018308176,
0.0078869965,
0.012767884,
-0.00448977,
-0.009722986,
0.03596988,
-0.04085723,
-0.023583414,
-0.026841648,
-0.026660636,
0.012283028,
0.023867862,
-0.0040243077,
0.00923813,
-0.015748136,
0.016045513,
0.033694286,
0.011151697,
-0.020467404,
-0.0022384203,
0.0012283028,
-0.006574652,
-0.0013834569,
-0.01510166,
-0.008236093,
-0.0035976344,
-0.020777712,
0.009399748,
-0.0048388666,
-0.009141158,
0.0012202219,
-0.020273462,
0.024759999,
0.0120826205,
0.01457155,
0.017312605,
0.006241718,
-0.004499467,
0.004341081,
-0.009813493,
-0.0046126004,
0.014739634,
-0.013963863,
0.0067815245,
0.011610694,
0.010466433,
-0.013769921,
0.025846077,
-0.008268417,
-0.032116886,
-0.0007975887,
0.009082976,
0.028419048,
-0.006710412,
-0.011539581,
-0.006167373,
0.014261242,
0.0035556133,
-0.0021753889,
-0.016446328,
0.010169054,
0.0043637073,
-0.017286746,
-0.028212177,
-0.6388209,
-0.019161524,
0.0070142555,
-0.006671624,
0.018075446,
0.0073504224,
0.024540197,
0.025690923,
-0.009167017,
0.018346965,
-0.013382036,
0.041038245,
0.030565346,
-0.019704564,
0.002382261,
-0.009451467,
-0.016989367,
-0.01302001,
0.023854934,
-0.017235028,
-0.0113133155,
0.0046061357,
-0.007938715,
0.0067168768,
0.008501149,
-0.0063192947,
0.03485794,
-0.015218025,
-0.0045802766,
0.046597928,
-0.009225201,
0.02267835,
0.012677378,
0.012011508,
0.043520708,
-0.015567122,
0.010679769,
0.021501765,
0.016976438,
0.012399393,
-0.010951289,
-0.003843295,
0.013123446,
0.004732198,
0.0003054595,
0.017312605,
0.02342826,
-0.010886642,
0.005546757,
0.0012670914,
-0.0060574724,
0.008501149,
-0.009231665,
0.009257524,
-0.00077334594,
-0.028496625,
-0.0020622557,
-0.019536478,
0.012457577,
-0.0013988107,
0.0037043027,
0.008061545,
-0.013213952,
-0.03565957,
0.0002080842,
0.0057148403,
-0.018553836,
-0.00076445687,
-0.0154378265,
-0.004570579,
0.023260176,
0.002821864,
-0.0032032845,
-0.014804281,
0.018540908,
0.0028057022,
0.012961827,
-0.01197272,
-0.027772574,
0.0057730232,
0.006038078,
0.0051556393,
-0.037055954,
-0.007899926,
0.026078807,
-0.022174098,
-0.028005304,
-0.0034748039,
0.015334391,
-0.000102930964,
0.016446328,
0.025690923,
-0.002640851,
-0.012030902,
-0.014364678,
0.02631154,
0.0007256684,
0.003120859,
-0.025380615,
-0.009050652,
-0.014196594,
-0.03721111,
0.017881503,
0.013123446,
0.00049414946,
-0.004774219,
-0.029763717,
0.00083556917,
0.049519997,
-0.01874778,
-0.012935968,
-0.0190193,
0.0021624593,
-0.004198856,
0.044580925,
-0.026634777,
0.008132658,
-0.004525326,
0.0014125482,
-0.03175486,
0.026182244,
0.015153377,
0.012328281,
0.011145231,
-0.003998449,
0.0036752112,
0.004593206,
-0.00631283,
0.00079435634,
-0.0012186057,
0.028393188,
-0.0055790804,
0.023298964,
0.016756637,
0.03669393,
-0.010240166,
0.025846077,
0.00552413,
-0.02888451,
-0.018411612,
-0.028936228,
-0.015980866,
-0.009884605,
0.029556844,
-0.013563049,
-0.035788864,
0.000842842,
-0.0059831277,
-0.009903999,
0.0034295507,
0.029065523,
-0.0044768406,
0.003070757,
0.025122024,
0.0076154773,
-0.018437471,
0.008158516,
-0.028832791,
-0.005427159,
0.002527718,
0.015347321,
0.008313671,
0.010472897,
0.0035814724,
-0.022497335,
-0.013705273,
0.024578985,
0.010524616,
-0.0042247153,
-0.03509067,
0.0066845533,
-0.022587841,
-0.015761064,
0.028289752,
0.009626015,
0.022536123,
-0.00076162856,
-0.018838286,
-0.011119373,
0.004900282,
-0.0046546212,
0.0007470829,
0.004017843,
0.00715648,
0.018618485,
-0.017855644,
0.0077770962,
0.013226882,
0.0072728456,
0.038219612,
-0.0104276445,
0.00028747943,
-0.0031871225,
0.0061576758,
-0.0072469865,
0.011242203,
-0.006930214,
0.02625982,
-0.013692344,
0.025884865,
0.044891234,
-0.015955007,
0.02315674,
-0.026970943,
0.009516114,
-0.014804281,
-0.013938004,
-0.015334391,
0.033125386,
-0.007628407,
-0.0021867023,
-0.019071016,
-0.012328281,
0.0043637073,
0.007751237,
0.001987911,
0.0034748039,
-0.0044606784,
-0.007861138,
-0.02186379,
-0.0017729581,
0.0009931475,
0.0200278,
-0.01771342,
-0.0074797175,
0.012522223,
0.009755311,
0.01691179,
-0.0041148146,
-0.019226171,
-0.009057117,
-0.025122024,
0.015631769,
0.0011224425,
0.006742736,
0.020182954,
-0.015786923,
-0.018799497,
0.01405437,
0.00068445556,
-0.012134339,
0.010595728,
-0.002133368,
0.021398328,
0.0058441353,
0.010880177,
0.020415686,
0.018683132,
-0.0040727933,
0.041814014,
0.00019889213,
0.02107509,
-0.03405631,
-0.029505126,
0.015528333,
-0.0075766887,
-0.0010998158,
0.02422989,
0.032375477,
0.022497335,
0.01952355,
-0.00023414522,
0.010434109,
0.009690663,
0.021514693,
-0.0008412258,
-0.013614767,
-0.005679284,
-0.0046222974,
0.04243463,
-0.008662767,
-0.05487281,
0.0028170154,
-0.012567477,
0.016873002,
0.014170735,
0.0025341827,
-0.011778777,
0.020622557,
-0.006800919,
-0.012392929,
-0.035323404,
0.0076154773,
0.018010799,
0.0027410546,
-0.012890715,
-0.010492292,
0.005352814,
0.0053366525,
0.012903644,
0.009755311,
0.011397357,
0.038633354,
0.018592626,
-0.0042214827,
-0.041762296,
0.03542684,
-0.013601838,
-0.00768659,
-0.017493619,
-0.00500695,
-0.016769566,
-0.012237775,
-0.012250705,
0.01746776,
0.015269743,
-0.005950804,
-0.04708925,
-0.013912145,
0.0066005113,
0.0226137,
-0.013252741,
0.0040243077,
0.0038045063,
0.013718203,
0.011436146,
-0.026272751,
0.030823935,
-0.0004169765,
-0.020144166,
-0.011778777,
-0.0400556,
-0.011358568,
-0.032944374,
0.025716782,
0.0050619007,
-0.0018699294,
0.013394965,
0.01536025,
0.031185962,
0.019859716,
-0.03227204,
0.01773928,
-0.0043507777,
0.011520187,
-0.012683842,
-0.0012000195,
0.0037851122,
0.018683132,
0.009412678,
0.0040566316,
-0.017247958,
0.010628052,
-0.0040954202,
0.0100139,
0.01261273,
0.028703498,
0.027720856,
0.029246537,
0.004360475,
0.013071728,
0.028315611,
0.01767463,
-0.00034162172,
-0.0010610274,
-0.00208165,
-0.018165952,
0.012147268,
-0.01798494,
-0.041245114,
0.011138767,
0.0070659737,
0.019058088,
0.00923813,
0.019135665,
0.02029932,
0.00897954,
-0.00016111373,
0.011410287,
-0.0018586161,
-0.009483791,
0.01510166,
-0.01688593,
-0.019420113,
0.010110872,
0.013472542,
0.006044543,
-0.024785858,
-0.0056728194,
-0.030875653,
-0.0043992633,
0.007072438,
-0.022665419,
-0.010834924,
-0.0017519477,
-0.026350327,
0.011365034,
-0.0071500153,
-0.017144522,
0.006280506,
-0.038866088,
-0.024695352,
-0.0043927985,
-0.0059572686,
0.012179592,
-0.019898506,
0.00429906,
0.021230245,
-0.012011508,
0.011028866,
0.014222453,
-0.028238036,
0.011287456,
0.027126098,
-0.011035331,
0.00014384072,
0.0011765847,
-0.027953586,
0.0021559948,
-0.0012072923,
-0.024966871,
-0.009710057,
-0.013149304,
0.025988301,
0.005168569,
-0.008565796,
0.010421179,
0.021450046,
-0.0046772477,
-0.015140449,
0.009593692,
0.033125386,
-0.014959435,
-0.015179236,
-0.022794714,
-0.024941012,
0.014532762,
-0.024656562,
0.017338464,
-0.0068138484,
-0.02836733,
-0.012910109,
-0.021967227,
-0.031185962,
0.01250283,
-0.009393284,
-0.013459613,
-0.0025212532,
0.031832438,
0.02265249,
-0.002477616,
0.012399393,
0.027410546,
-0.007188804,
-0.0072534513,
0.0061803027,
0.024268677,
0.0032824776,
-0.01457155,
0.0010117337,
0.0075379005,
-0.022238746,
-0.028703498,
-0.002640851,
-0.015605911,
0.051407706,
0.0094967205,
-0.01379578,
-0.032349616,
0.017506547,
-0.010039759,
-0.004276433,
0.024630703,
-0.038374767,
0.00643566,
-0.0069366787,
-0.013873357,
0.0065908143,
-0.0005204125,
-0.030901512,
0.005262308,
0.014170735,
-0.016472187,
-0.022316322,
0.0075443652,
-0.006703947,
-0.01078967,
0.023570484,
-0.036073312,
-0.0064130337,
0.00077859854,
0.004334616,
0.025173742,
0.019213242,
0.024837576,
-0.007874068,
-0.0012363837,
0.011093514,
0.02602709,
0.018023727,
-0.01848919,
0.01719624,
-0.021721566,
0.027798431,
0.027126098,
-0.0006359699,
-0.0021366004,
-0.024139382,
0.012515759,
-0.0044445167,
-0.009865211,
-0.038607497,
-0.022432689,
-0.0140673,
-0.011481399,
0.01236707,
-0.001711543,
-0.00404047,
-0.028832791,
-0.02028639,
0.02110095,
0.015696418,
0.012877786,
-0.006710412,
0.00689789,
0.0023450886,
0.01223131,
0.010867247,
-0.0056469603,
0.005223519,
-0.006183535,
-0.0004078854,
-0.008527007,
0.0048291693,
-0.0078869965,
0.0062740413,
0.0050037177,
-0.02364806,
0.011759384,
0.028315611,
-0.020674275,
-0.01740311,
-0.022536123,
-0.0077124485,
-0.0123864645,
-0.007389211,
-0.0039596604,
-0.021656917,
-0.0138992155,
-0.0012800208,
-0.011242203,
0.0039790547,
-0.008371853,
-0.006021916,
0.0022642792,
-0.029711999,
0.017778067,
-0.026479622,
0.034728646,
0.036280185,
-0.0068914252,
-0.009548438,
-0.019885575,
0.018010799,
0.002398423,
0.025535768,
0.046546213,
-0.0062740413,
-0.00689789,
-0.0016565926,
0.010169054,
-0.02319553,
-0.037573136,
0.015592981,
0.0022852896,
-0.0070918323,
-0.013718203,
-0.00078021473,
-0.037676573,
0.029039664,
-0.0027976213,
0.023906652,
0.007182339,
-0.021049231,
0.0048453314,
0.016355822,
-0.011985649,
0.006872031,
0.004198856,
-0.012742026,
-0.01458448,
-0.02028639,
0.0036913732,
-0.0037818798,
-0.008152052,
0.01300708,
-0.002726509,
-0.017933222,
-0.00075475976,
-0.011591299,
0.013938004,
0.0066199056,
-0.0143905375,
0.035995737,
0.009554903,
-0.014080229,
0.028962087,
-0.008759739,
-0.0018262924,
-0.0033616708,
0.01092543,
-0.02653134,
-0.012114945,
-0.0011192102,
0.01825646,
0.040779654,
-0.0022060964,
0.018605554,
-0.008785597,
0.0052946317,
-0.0037818798,
-0.035685427,
0.031729,
-0.016446328,
-0.00020929633,
-0.026427904,
0.00059920165,
-0.004573812,
0.025807288,
0.009121764,
-0.011248668,
0.01156544,
-0.012858391,
0.013369107,
0.005614637,
0.018346965,
-0.028238036,
0.00331965,
-0.033668425,
-0.017855644,
-0.0057148403,
-0.0032630833,
-0.038891945,
-0.03390116,
-0.011507258,
0.0033051043,
0.027229534,
-0.014235383,
0.050399203,
-0.005032809,
0.013252741,
0.0019507388,
-0.022872292,
0.036228467,
-0.022755926,
0.017920291,
0.022303393,
-0.018799497,
0.008313671,
-0.0034683393,
0.025729712,
-0.015631769,
-0.03043605,
-0.019601127,
-0.012153733,
0.023066234,
-0.01797201,
-0.01261273,
-0.009768239,
-0.0057503968,
-0.0077706315,
-0.0066780886,
0.019562338,
-0.01587743,
-0.01312991,
0.013239811,
0.010757347,
-0.016058443,
0.007815884,
-0.028160458,
0.004732198,
-0.006904355,
-0.0047192685,
-0.006597279,
-0.010990078,
0.04499467,
0.011623624,
-0.0050974567,
-0.022316322,
-0.03721111,
-0.039667714,
0.020480333,
-0.008675696,
0.00897954,
0.01157837,
0.005281702,
0.009451467,
0.013407894,
-0.0027830757,
0.0059960573,
-0.010091477,
-0.031366974,
0.008145587,
-0.01431296,
0.041296832,
0.005653425,
-0.038685072,
0.008061545,
0.04445163,
-0.0020153862,
-0.016704919,
0.02602709,
-0.000073132505,
-0.005882924,
-0.029996447,
0.022212887,
-0.020273462,
-0.0066974824,
0.00897954,
-0.04140027,
-0.022833502,
0.025936583,
-0.0049229083,
-0.025535768,
0.006115655,
0.0041568354,
0.007001326,
-0.008468824,
-0.005873227,
-0.0380386,
0.018799497,
-0.017118663,
-0.016420469,
-0.0043216865,
0.02421696,
-0.007621942,
0.0059281774,
-0.009393284,
-0.0050198794,
0.00794518,
0.002021851,
0.0057697906,
0.017002298,
0.003552381,
0.005394835,
0.0007329412,
0.006002522,
-0.0090765115,
-0.0047095716,
0.0055693835,
0.0015620457,
-0.012043832,
0.025755571,
0.016821284,
0.008358924,
-0.023286035,
0.0016105312,
-0.004396031,
-0.015696418,
-0.0020331645,
0.009289848,
-0.018282317,
0.008623979,
-0.0034877334,
-0.0039628926,
0.008520543,
0.00058425195,
-0.021812072,
-0.013382036,
0.007848209,
0.1717038,
-0.005763326,
0.018618485,
-0.0035297545,
-0.027746715,
0.01926496,
0.021682777,
-0.0027879241,
-0.002513172,
0.02885865,
0.016601482,
-0.0020250834,
-0.014351749,
0.0055758483,
-0.0024355953,
-0.011533117,
-0.04085723,
-0.03617675,
-0.009535508,
-0.0063968715,
-0.0075443652,
0.028031163,
0.019976083,
-0.0137828505,
0.0051039215,
-0.0005066749,
-0.028160458,
0.011630088,
0.0074732527,
-0.007059509,
0.0015111357,
-0.03661635,
-0.0067556654,
-0.0026715586,
0.006280506,
-0.018346965,
-0.018864146,
-0.015476615,
0.0032242949,
-0.0150887305,
-0.0210363,
0.041503705,
-0.025665063,
-0.027410546,
0.0017729581,
0.022717137,
0.019368395,
-0.04183987,
-0.0014165887,
-0.00086950907,
-0.034030452,
-0.0241911,
0.02473414,
0.026919225,
-0.0078417435,
0.008934286,
0.023790285,
0.0038077387,
-0.02058377,
0.029013805,
0.003120859,
-0.0051071537,
-0.0029269163,
0.019782139,
-0.012289492,
0.016006725,
-0.00026384267,
-0.012147268,
0.021928437,
-0.013860428,
0.011358568,
-0.03020332,
-0.024837576,
0.018114233,
0.00806801,
-0.010679769,
-0.0057730232,
0.03043605,
0.025600417,
0.01876071,
0.0056728194,
-0.011403821,
-0.023570484,
0.01274849,
-0.016860072,
-0.02991887,
0.026608918,
-0.0064550545,
-0.02006659,
0.03772829,
-0.011636553,
-0.030875653,
-0.013407894,
-0.014183665,
0.027488124,
0.006529399,
-0.01130685,
-0.017868573,
0.013705273,
-0.014532762,
-0.022355111,
0.10483241,
-0.009283383,
0.018308176,
-0.00846236,
-0.0031273237,
-0.0075379005,
-0.009794098,
-0.0019830626,
-0.0105440095,
0.014752563,
-0.030591205,
0.0041148146,
-0.032840937,
0.008294276,
0.022781784,
0.012257169,
-0.018308176,
0.023816144,
0.008281346,
0.009167017,
-0.028806932,
-0.004405728,
0.018915864,
-0.0069431434,
-0.005090992,
-0.02421696,
0.00046303784,
-0.001633966,
-0.023143811,
0.02550991,
-0.0072987047,
-0.009386819,
0.002459838,
0.0057730232,
0.006539096,
0.003907942,
-0.027539842,
-0.02989301,
0.025432333,
0.009878141,
-0.016019655,
0.01589036,
-0.009167017,
0.00638071,
-0.015825711,
0.006539096,
-0.0016404308,
-0.008682162,
-0.0067879893,
0.0069883964,
-0.020454474,
0.00094546995,
-0.01873485,
0.0020687205,
-0.012373535,
-0.005908783,
-0.016174808,
0.0009745613,
0.003500663,
-0.03666807,
0.005737467,
0.03250477,
-0.003233992,
-0.023092093,
0.013563049,
-0.16001554,
0.0143905375,
0.011869284,
0.0033164176,
0.024837576,
0.0019733654,
0.011074119,
0.014261242,
0.008468824,
0.0149723645,
0.026272751,
-0.0031079294,
-0.03333226,
-0.021462975,
0.013039404,
-0.015489545,
-0.02810874,
0.034754504,
0.053941887,
-0.008384783,
0.0328668,
-0.02134661,
0.0043798694,
-0.018941723,
0.00624495,
0.02054498,
-0.017273815,
-0.011203415,
0.01130685,
0.010007435,
0.01483014,
0.015605911,
0.048046034,
-0.0050101825,
-0.013886287,
-0.0011814333,
-0.0033487412,
0.03123768,
-0.010634516,
0.017118663,
0.041141678,
0.01511459,
-0.0010513302,
-0.005488574,
-0.01746776,
0.028470766,
0.017041085,
-0.012670913,
0.007130621,
0.014558621,
0.030487768,
-0.013744062,
0.024087664,
0.002527718,
0.006235253,
-0.010938359,
-0.006005754,
-0.005246146,
0.014881859,
0.012483436,
-0.0059217126,
-0.024242818,
0.025380615,
-0.0043313834,
0.023467049,
-0.025458192,
-0.0071112267,
-0.009852282,
-0.0017551801,
0.030280897,
-0.041219257,
0.004467143,
-0.0063257595,
-0.013498401,
0.02525132,
0.02185086,
-0.03250477,
0.010821994,
0.009529044,
0.010970684,
-0.008042151,
-0.020493263,
-0.0156447,
-0.0025584255,
-0.038426485,
-0.014144876,
0.0103112785,
-0.007389211,
-0.015541263,
-0.0070401146,
0.0047806837,
-0.018773638,
-0.011248668,
-0.0061803027,
-0.019963153,
0.01900637,
0.019588197,
0.0156447,
0.0015959855,
-0.010589263,
0.019743351,
-0.008876104,
-0.018618485,
-0.0013559817,
0.015502474,
-0.020221744,
-0.028315611,
-0.00058182765,
0.050787088,
0.006209394,
-0.014468114,
0.035038956,
0.008126193,
0.010763811,
-0.0071952688,
-0.0007107186,
-0.016148949,
-0.012451111,
-0.020118307,
-0.025160814,
0.055803735,
0.010834924,
-0.028936228,
0.007356887,
-0.014881859,
0.0011410287,
-0.13095,
-0.026246892,
0.025574557,
0.0005571808,
0.0027798433,
0.037676573,
0.016342891,
-0.0034424802,
0.00028707538,
0.00572777,
-0.017235028,
-0.021837931,
-0.011811101,
-0.027384687,
0.017855644,
0.013950934,
0.017299674,
-0.00058101956,
-0.027876008,
0.019536478,
-0.0018650808,
-0.00872095,
0.014920646,
0.00045616904,
0.0055952426,
-0.0008141546,
0.0024226657,
0.009942788,
0.014765493,
0.030306755,
0.012011508,
0.0076413364,
0.0019135665,
0.011979185,
-0.012742026,
-0.016485117,
-0.016898861,
0.00500695,
0.03022918,
-0.022458548,
0.014364678,
0.013614767,
0.009257524,
-0.023467049,
0.035194106,
-0.007027185,
-0.010130266,
-0.011474934,
-0.0007466788,
-0.002364483,
-0.009522579,
-0.019458903,
-0.033125386,
-0.02291108,
0.016523905,
-0.029530985,
0.01209555,
0.043443132,
-0.01847626,
-0.0051039215,
-0.011035331,
-0.007680125,
-0.012670913,
0.006568188,
0.019161524,
-0.014429325,
-0.001264667,
-0.010298349,
0.02263956,
-0.046494495,
-0.011041796,
-0.04711511,
-0.023454119,
-0.01353719,
-0.017260887,
0.016019655,
0.007369817,
-0.031547986,
0.00178912,
-0.00741507,
-0.0059475712,
-0.014610339,
0.015748136,
0.017066944,
0.0052752374,
0.0002244481,
0.019717492,
-0.0010990078,
-0.018941723,
-0.010595728,
-0.004728966,
0.038891945,
-0.011462005,
-0.015230955,
-0.00578272,
-0.017028155,
0.0014287101,
-0.018334035,
0.01352426,
0.031832438,
-0.013252741,
0.0062611117,
-0.057665583,
0.014119018,
0.0030416655,
-0.023906652,
0.013071728,
0.00072041573,
-0.0028848953,
0.0006169797,
-0.009044187,
-0.008274882,
-0.031625565,
0.008753274,
-0.011739989,
0.014093159,
-0.017584125,
0.021786213,
0.027694996,
0.00912823,
0.021812072,
0.0038853157,
0.002726509,
-0.0045899735,
0.009645409,
0.02159227,
0.009018328,
0.0009487023,
0.0034457126,
0.02473414,
-0.01874778,
0.0017050783,
0.0052687726,
-0.007699519,
0.0050780624,
-0.0013705273,
0.007783561,
-0.0030675246,
0.027255394,
0.016601482,
0.009832887,
0.041736435,
-0.018527977,
-0.0249798,
0.0025648903,
0.0026343863,
0.0012913342,
-0.008578725,
-0.013252741,
0.02263956,
0.010278955,
-0.015399038,
0.012379999,
0.015812783,
-0.012056761,
-0.011423216,
-0.049856164,
0.011630088,
-0.0067879893,
-0.02785015,
-0.01925203,
-0.023117952,
0.0017002297,
-0.0153214615,
0.003086919,
0.0065326313,
0.011604229,
-0.0062255557,
-0.01794615,
-0.004001681,
0.023596343,
0.010000971,
-0.025690923,
-0.003269548,
-0.019239102,
0.004754825,
0.005417462,
-0.01926496,
-0.015980866,
0.03408217,
0.004644924,
-0.001255778,
-0.003104697,
-0.008914893,
-0.008552866,
0.02186379,
0.018657273,
0.009916929,
-0.00016222487,
0.024333324,
0.011132303,
0.001633966,
-0.009276918,
0.014144876,
-0.012444647,
0.024643634,
-0.005915248,
0.01925203,
-0.0037818798,
-0.0110805845,
-0.008281346,
0.03462521,
-0.0007353655,
0.0154378265,
-0.0021624593,
0.010052688,
-0.010343603,
0.015567122,
-0.0343149,
-0.04706339,
-0.008688626,
0.009677733,
0.012063227,
0.0090765115,
0.010893106,
-0.00085981196,
-0.0150887305,
0.0152050955,
-0.003250154,
0.020338109,
-0.002812167,
0.022148238,
-0.00026444875,
0.02082943,
0.017312605,
-0.010421179,
0.03353913,
0.0025406473,
0.010699164,
-0.021450046,
0.015230955,
0.0115007935,
0.009367425,
-0.017041085,
-0.030513627,
-0.009141158,
-0.029970588,
-0.02916896,
0.0027168118,
-0.013407894,
0.002812167,
0.06190646,
-0.0041826945,
-0.032711644,
-0.0055338275,
-0.0048194723,
0.010085013,
0.006574652,
0.015075801,
-0.012561012,
-0.012509295,
0.014597409,
-0.011164626,
0.016252385,
-0.039745294,
-0.014196594,
-0.000087779204,
0.0025503444,
0.00820377,
0.0017083106,
-0.016019655,
0.004961697,
0.004955232,
0.014287101,
-0.00016555825,
-0.025044447,
0.0007086984,
0.024255749,
-0.025587486,
-0.027358828,
-0.02450141,
-0.0061803027,
-0.013563049,
-0.04108996,
-0.029867152,
0.020622557,
-0.010867247,
-0.034909658,
-0.010181984,
0.015011153,
-0.008384783,
0.0027135795,
0.004059864,
-0.014946505,
-0.021424187,
0.0009955717,
-0.031729,
-0.04034005,
-0.013369107,
0.001066684
] |
The novel phosphatidylinositol-3-kinase (PI3K) inhibitor PX-866 was tested against 13 experimental human tumor xenografts derived from cell lines of various tissue origins. Mutant PI3K (PIK3CA) and loss of PTEN activity were sufficient, but not necessary, as predictors of sensitivity to the antitumor activity of the PI3K inhibitor PX-866 in the presence of wild-type Ras, whereas mutant oncogenic Ras was a dominant determinant of resistance, even in tumors with coexisting mutations in PIK3CA. The level of activation of PI3K signaling
|
[
-0.011719434,
-0.03688214,
0.007596919,
-0.021835295,
-0.006818519,
0.03589327,
-0.036053628,
-0.010095818,
-0.02146113,
-0.008652603,
0.020873154,
-0.0026826411,
0.013142603,
0.012160416,
-0.019229492,
0.008158169,
0.031456724,
-0.015407647,
0.00009395926,
0.010162633,
-0.015127023,
0.0031670532,
-0.015621457,
-0.019015683,
-0.002042883,
0.012841933,
0.015581368,
-0.055964638,
-0.013964433,
-0.020271813,
0.016743956,
0.017037945,
0.004763943,
0.010449939,
-0.012882023,
0.011265088,
0.029746247,
-0.02215601,
0.008338571,
-0.0037784148,
0.010089136,
-0.0035612646,
-0.0035311976,
-0.0030584782,
-0.021100326,
-0.0036514655,
0.0053352155,
-0.012988928,
-0.02085979,
0.026659373,
-0.007423199,
0.000330319,
0.00410247,
-0.0022533517,
-0.0072227526,
-0.015594731,
0.017225029,
0.017198302,
0.0038251856,
0.005178199,
-0.00045685077,
-0.0019877602,
-0.014151516,
0.015902082,
0.00842543,
0.016289612,
0.013550177,
0.0067216363,
0.008986681,
0.0076904604,
0.040837616,
0.021220593,
-0.015755087,
-0.010790698,
0.020939969,
-0.009420982,
-0.034824222,
0.008906502,
-0.00392875,
0.030868748,
0.028089223,
-0.023759581,
-0.016637051,
0.018320803,
0.022997884,
-0.00003434733,
0.0032539135,
0.017786277,
0.002707697,
0.009414299,
0.030414402,
0.013964433,
0.009855282,
0.010550163,
-0.011184909,
0.01615598,
-0.007490014,
0.005188221,
-0.011980014,
-0.050993565,
0.0044499105,
-0.0020529053,
0.0036381024,
-0.020632617,
-0.0342897,
0.00048357697,
-0.014672677,
-0.0023502342,
-0.0008460509,
0.021274045,
-0.017612558,
0.03995565,
-0.004633653,
-0.02707363,
0.039421126,
-0.00855238,
0.019403212,
0.007670416,
-0.0067483624,
-0.010937693,
0.011191592,
0.02832976,
0.012634805,
-0.0022817482,
0.03506476,
0.0009763411,
-0.009567975,
-0.009955505,
-0.0337819,
-0.007062395,
0.00820494,
0.01999119,
0.006330766,
-0.022971159,
-0.020164909,
0.02039208,
-0.025162706,
-0.03001351,
-0.022583628,
-0.050993565,
-0.0054320977,
0.016596964,
0.009167083,
-0.006621413,
-0.0053318744,
-0.006841904,
0.008124761,
-0.0030801932,
0.0062839948,
0.012427677,
0.0073764278,
0.003985543,
0.0058363313,
-0.00811808,
0.0035779683,
-0.0051247464,
-0.0056292033,
0.033354282,
-0.016877588,
-0.008265073,
-0.0062205205,
-0.017933272,
-0.00920049,
0.00855238,
0.04345678,
0.022436636,
0.032365415,
0.009367529,
-0.013910981,
0.012875341,
0.014178243,
0.04236101,
-0.02677964,
0.028703926,
-0.009267306,
0.008318526,
0.0032271873,
0.026017943,
-0.0082918,
0.017599195,
-0.012815207,
0.03183089,
0.02345223,
0.004069062,
-0.010877559,
-0.0020796314,
0.011024552,
-0.023104789,
-0.0014198287,
-0.026886545,
0.006688229,
0.00496773,
-0.0033023546,
-0.008478883,
-0.643139,
-0.027501248,
0.0008969977,
-0.015434374,
0.03952803,
0.038405534,
0.02068607,
-0.017799642,
-0.021821933,
0.0064978045,
-0.009086904,
-0.0023719491,
0.001308748,
-0.027902141,
-0.03570619,
-0.040089283,
-0.018173808,
-0.02854357,
0.028917735,
0.0050813165,
0.01183302,
0.010563526,
-0.005381986,
0.021928838,
0.016570237,
0.016516784,
0.011131457,
-0.024213927,
0.005001138,
0.029906604,
-0.019269582,
0.024721725,
-0.0029565846,
0.012334135,
0.0399022,
-0.021795206,
0.011853064,
0.03549238,
0.025122616,
0.04845458,
-0.007329657,
0.022623718,
0.02172839,
0.015260654,
-0.03498458,
0.021527944,
0.009527886,
0.0034777452,
0.0036915548,
0.005505595,
-0.0038018003,
-0.0019226151,
-0.02211592,
0.012942157,
0.010022321,
0.005164836,
0.015447737,
-0.008752827,
0.006016733,
0.017131487,
0.0078107286,
0.013469999,
-0.0018725035,
-0.036828686,
-0.011866428,
0.03070839,
-0.0041793077,
0.005913169,
0.002832976,
-0.0044298656,
0.03864607,
0.032552496,
-0.008572425,
0.016262885,
0.0009938801,
0.022383183,
0.013416546,
0.008445475,
0.0073831095,
-0.0063040396,
0.008632558,
-0.002124732,
-0.04794678,
0.034717318,
0.024080295,
0.015113659,
-0.020953331,
-0.0014365326,
0.012521219,
-0.0065746424,
0.017211664,
-0.014245058,
-0.02958589,
-0.02608476,
-0.014231695,
0.02289098,
-0.0024738428,
0.015568005,
0.016262885,
-0.04220065,
-0.036213987,
-0.010075773,
-0.01602235,
-0.0062639504,
0.032579225,
-0.02569723,
-0.03562601,
-0.00087862345,
0.03934095,
-0.050352138,
0.0006184607,
-0.0033324216,
0.009995595,
-0.0027862052,
0.021300772,
-0.022663807,
0.021153778,
0.005589114,
-0.0064076036,
-0.047144994,
0.011599165,
-0.002863043,
0.0090267705,
-0.023144878,
0.018347528,
0.013576903,
0.0052149473,
0.0054254164,
0.002846339,
-0.0010657067,
0.0013371446,
-0.011946606,
0.015113659,
-0.019269582,
0.005251696,
0.011198273,
0.008699374,
0.01088424,
0.0044866586,
-0.015621457,
-0.04078416,
-0.011385356,
-0.006481101,
0.034262974,
-0.013176011,
-0.03303357,
-0.025510147,
0.0047706245,
0.015006755,
0.009681562,
0.017692737,
-0.00035725397,
0.022637082,
0.0062773135,
0.026632646,
-0.01766601,
0.013924344,
-0.021140415,
-0.010129225,
-0.010937693,
-0.008084672,
-0.009080223,
0.009721651,
-0.013256189,
-0.013670445,
-0.021327497,
0.020846426,
0.010356398,
-0.005595796,
-0.03268613,
-0.028837558,
-0.016730594,
-0.030200593,
-0.012728347,
0.0096013835,
0.019670475,
-0.006377537,
-0.009160401,
-0.006033437,
0.008191576,
0.0015467781,
-0.0349044,
-0.03303357,
0.013790713,
0.01852125,
0.028356485,
0.013049061,
0.030868748,
-0.0057929014,
0.030735116,
-0.021514582,
0.0020445534,
0.007910952,
0.024654908,
0.0058496944,
-0.009287351,
0.023118153,
0.016743956,
-0.0073430203,
0.029692795,
0.014686041,
0.00052366627,
0.021140415,
-0.012755074,
0.011686026,
-0.016984493,
-0.003377522,
-0.045167256,
0.020779612,
0.008024538,
0.013035698,
0.0309222,
-0.030948926,
0.0046102675,
-0.01787982,
-0.00005548816,
-0.0036247394,
-0.018801874,
-0.014138154,
-0.038031366,
-0.019964462,
0.014525684,
0.010256175,
-0.0055690696,
-0.0018157104,
0.009180445,
0.029184997,
0.02099342,
0.018334165,
-0.0011726115,
-0.031643808,
-0.00064978044,
-0.0030000147,
0.014178243,
0.0071292105,
0.006223861,
0.0072494787,
-0.006357492,
0.024681635,
-0.0007500037,
0.028917735,
0.0036481246,
-0.012086919,
-0.0029031322,
-0.0044732955,
-0.007329657,
0.028650474,
0.02768833,
-0.026752915,
0.015768452,
0.0025239545,
0.023398777,
-0.012200505,
0.0017505654,
0.021193868,
-0.016343065,
0.02811595,
0.042467915,
0.042307556,
0.022396546,
0.010029002,
-0.00643433,
0.016249523,
0.00081514876,
-0.0072093895,
0.011772886,
0.019162677,
0.0046704016,
-0.008084672,
0.003965498,
-0.014726129,
-0.003015048,
0.009000043,
-0.020552438,
-0.008779553,
0.0042361007,
0.012962202,
-0.022262914,
0.02478854,
0.004095788,
-0.00072453025,
-0.044205114,
0.030842021,
0.020833064,
-0.0055356617,
-0.020899879,
-0.02889101,
-0.0012210527,
0.016877588,
-0.001710476,
-0.0051581543,
0.002138095,
-0.0017639284,
-0.016062438,
-0.021260682,
-0.03784428,
0.009748377,
-0.022222826,
0.014044612,
-0.0032839803,
0.018694969,
-0.011665981,
-0.0050078193,
0.007804047,
0.027287439,
-0.007329657,
0.002181525,
-0.015314106,
0.0026442222,
-0.01783973,
-0.0059666215,
-0.008659285,
0.004954367,
-0.013269552,
-0.015354195,
0.0037283031,
0.014258421,
0.007302931,
0.03196452,
-0.015300742,
0.0024688316,
-0.0196972,
-0.004129196,
-0.016543511,
0.02685982,
0.007490014,
0.00725616,
0.01265485,
0.0026341998,
-0.0028780764,
-0.017064672,
-0.025282973,
0.023091426,
-0.0072962493,
-0.009454389,
0.008311844,
0.000628483,
-0.0041124923,
0.025911039,
0.02029854,
-0.0084053865,
-0.034530234,
-0.010630341,
-0.004025632,
0.00885305,
-0.00071576075,
0.025429968,
0.029158272,
0.020846426,
-0.006648139,
0.008859731,
0.034931127,
0.014378689,
-0.012180461,
-0.021354225,
-0.0028095904,
-0.011772886,
0.0026625965,
0.0012335806,
-0.037363213,
-0.0040790844,
0.013844165,
0.0030584782,
-0.0058931243,
0.01235418,
-0.0009997265,
-0.002600792,
0.011873109,
-0.018240623,
-0.023465592,
-0.006180431,
0.014392052,
-0.010737246,
-0.017866457,
0.031804163,
-0.007282886,
-0.031456724,
-0.023599224,
0.010596934,
0.028436664,
0.007630327,
-0.011492261,
-0.014071338,
-0.015260654,
-0.00535526,
-0.014204969,
-0.011672663,
-0.018761784,
-0.0044098212,
-0.0025022393,
0.0066915695,
-0.017759552,
-0.04262827,
-0.0044031395,
0.009868645,
-0.0070289876,
0.000352034,
0.0005407877,
0.010543481,
-0.0019894305,
0.013977797,
-0.009066859,
-0.00043513576,
0.03624071,
-0.0006552092,
-0.003407589,
-0.008532336,
-0.03666833,
0.019162677,
0.012541263,
0.009060178,
-0.022356456,
-0.007463288,
-0.007870862,
0.007035669,
-0.019790743,
-0.009447708,
-0.011906517,
0.004466614,
-0.0052283104,
0.014245058,
0.012447722,
-0.012367544,
0.012641487,
0.003200461,
-0.025590325,
-0.012200505,
-0.013276234,
-0.017612558,
0.010389806,
0.006050141,
-0.009755058,
-0.011806293,
0.0077505945,
-0.008913184,
0.00062388944,
-0.015568005,
-0.011899835,
0.0050813165,
0.014325237,
-0.00015555476,
0.006915401,
-0.0006422637,
-0.00246215,
-0.03851244,
0.008893139,
0.01791991,
-0.0137639865,
-0.013496725,
0.004072403,
-0.007850817,
-0.008331889,
-0.017692737,
-0.015274016,
-0.005131428,
0.039634936,
-0.0034977898,
-0.0020362015,
-0.010717201,
0.0017438838,
-0.030227318,
-0.013804076,
-0.0026893227,
-0.014191606,
-0.0043329834,
0.006724977,
0.030307498,
-0.010810743,
-0.01416488,
-0.0309222,
-0.03813827,
0.026525741,
-0.009247261,
0.0012811866,
-0.006190453,
0.007596919,
-0.011351949,
-0.004814055,
-0.029078092,
-0.02854357,
-0.017826367,
0.016062438,
0.021073598,
0.048855472,
0.017131487,
-0.008251711,
0.001718828,
0.04241446,
0.0030568077,
-0.00076086115,
-0.0017255095,
0.023478957,
-0.030948926,
0.029318629,
0.0055924547,
0.003835208,
0.032712854,
0.004560156,
0.017078035,
0.0014741163,
-0.016129255,
-0.014325237,
0.002440435,
-0.035946723,
-0.029078092,
0.018374255,
-0.013022335,
-0.011632574,
-0.0410247,
-0.0024304127,
0.023599224,
-0.0025840884,
0.019443301,
0.0064543746,
0.009915416,
-0.022369819,
0.015380921,
-0.001520052,
0.006474419,
0.003554583,
-0.021995652,
0.010202723,
-0.0040623806,
0.003942113,
-0.008712737,
0.017037945,
0.018040176,
-0.00665148,
-0.01675732,
0.015153749,
0.00582965,
-0.000048676113,
-0.019309672,
-0.036053628,
-0.006948809,
-0.00015743395,
-0.014111428,
-0.01852125,
-0.015180475,
0.015086933,
-0.028677199,
0.0022433293,
-0.011539032,
-0.025189431,
0.017265117,
-0.0022700557,
0.039234046,
-0.009634791,
0.034850948,
0.035572555,
0.013750624,
-0.018855326,
-0.01619607,
-0.0061102747,
-0.004720513,
0.033808626,
0.029639343,
-0.007483333,
-0.014806308,
0.010757291,
0.03567946,
-0.034102615,
-0.033594817,
0.009133675,
-0.018815236,
0.013022335,
-0.010510073,
-0.018120356,
-0.02832976,
0.022957796,
-0.0073964726,
0.021367587,
0.0016837498,
-0.0014632588,
-0.012674895,
0.008138124,
-0.005034546,
0.005826309,
-0.00220324,
-0.0068819933,
0.010637023,
-0.028597021,
0.019229492,
0.01999119,
-0.008759508,
0.022062467,
0.007069077,
0.001974397,
0.009153719,
-0.0062572686,
0.0275547,
0.0053786454,
0.0034309744,
0.044953447,
0.007596919,
-0.013155966,
0.033541366,
-0.003273958,
-0.0060534817,
-0.0050378866,
-0.01139872,
-0.03399571,
-0.029933332,
0.010002276,
0.016356427,
-0.0029164953,
-0.005712723,
-0.002928188,
-0.017198302,
0.0023335302,
-0.021795206,
-0.018213898,
0.01826735,
-0.04249464,
-0.01675732,
-0.0022249552,
0.0028530206,
0.016463332,
0.016610326,
-0.0012277343,
-0.001114148,
0.017572468,
-0.025991218,
0.004413162,
0.014498957,
0.007944359,
-0.025389878,
0.00669491,
-0.015861992,
-0.025777409,
0.017225029,
-0.013102514,
-0.022075832,
-0.025416605,
-0.010035683,
0.0073563834,
0.015888719,
-0.015688272,
0.0036514655,
0.015033481,
0.017398749,
-0.010129225,
-0.01101119,
-0.017171577,
-0.031670533,
0.015314106,
0.013282916,
-0.016596964,
-0.027020177,
-0.01200674,
-0.009213854,
-0.0033407735,
0.005148132,
-0.0045802006,
-0.018000087,
-0.0069354456,
-0.0044098212,
0.005929873,
0.00837866,
-0.03105583,
-0.03134982,
0.014953302,
0.021394314,
-0.0011333574,
-0.010817424,
0.001036475,
0.0011951617,
0.0030267409,
-0.035091486,
0.0041960115,
-0.016730594,
-0.0239333,
-0.04086434,
0.0051080426,
-0.015434374,
0.03156363,
0.018240623,
-0.015220564,
-0.013115876,
-0.014204969,
-0.0275547,
-0.014579136,
-0.011786249,
0.0012026784,
-0.017652648,
0.010389806,
-0.016917678,
0.009942142,
-0.012588034,
-0.004115833,
0.007837455,
-0.027501248,
0.013082469,
-0.016957765,
0.019897647,
0.0053318744,
-0.036026902,
-0.015447737,
0.052490234,
-0.008625877,
-0.011071323,
0.048214044,
-0.030467855,
0.013830802,
0.004426525,
0.0174522,
0.013697172,
0.021113688,
0.033835355,
-0.02910482,
0.008973317,
0.0196972,
0.0096013835,
0.0008694363,
-0.0056759743,
-0.011365311,
0.011371993,
-0.006417626,
0.005251696,
-0.027821962,
-0.00185747,
0.008151487,
0.006384218,
0.009307395,
0.014098064,
-0.00569936,
0.018213898,
-0.008806279,
-0.019550206,
0.007971086,
-0.018561337,
-0.0003783426,
0.024000118,
-0.0014699403,
-0.0040089283,
-0.010396487,
-0.0015066889,
-0.017519016,
-0.021741753,
0.016810773,
0.021100326,
-0.010095818,
0.031082558,
0.01183302,
0.0027110376,
-0.0055991365,
0.0038519118,
-0.010550163,
-0.01412479,
-0.01904241,
0.012420996,
-0.02958589,
-0.011298496,
0.007289568,
-0.01023613,
0.008879776,
0.0038585935,
-0.015020118,
-0.025029074,
0.027180534,
0.18419689,
0.01952348,
0.00946107,
0.023772944,
0.018040176,
0.008371978,
0.002440435,
-0.0013012313,
-0.00062347186,
-0.00643433,
0.01861479,
-0.004089107,
-0.013530132,
-0.009701606,
0.007884226,
0.011071323,
-0.011525668,
-0.011184909,
-0.003312377,
0.0013404854,
0.02958589,
0.00686863,
0.010169314,
-0.0027611493,
0.030227318,
-0.0043263016,
-0.008665967,
0.012902067,
0.008599151,
0.016035713,
-0.02811595,
0.006888675,
0.021327497,
0.010483347,
-0.014204969,
0.00065980275,
-0.026499016,
0.0012970553,
0.014445505,
-0.009815193,
-0.0017029593,
-0.009828555,
-0.007650371,
0.0049610487,
-0.014445505,
0.022396546,
-0.0046670604,
-0.008365297,
0.005726086,
-0.0019192743,
-0.030521307,
0.006902038,
0.023225058,
0.010924329,
-0.018574702,
-0.005265059,
0.023772944,
-0.0058931243,
-0.0020846426,
0.01714485,
-0.00773055,
-0.016062438,
-0.022182737,
0.008525654,
-0.010763972,
0.03113601,
-0.01991101,
-0.0028713949,
0.013436591,
-0.0049610487,
-0.015274016,
0.003001685,
-0.001408136,
0.0069421274,
-0.003157031,
-0.027527973,
0.019242855,
0.010309627,
0.04150577,
0.0027494566,
0.0098486,
0.01598226,
-0.019242855,
0.010135907,
-0.024374284,
-0.0230647,
0.018815236,
0.0054254164,
0.006611391,
0.027260711,
-0.0021531286,
-0.013209418,
-0.023572497,
0.00037145225,
0.009908734,
-0.0018290735,
-0.0036180578,
0.018307438,
-0.024026843,
-0.024441099,
-0.026164938,
0.08130106,
-0.02699345,
0.0025974514,
-0.02215601,
0.002949903,
0.0032539135,
0.0047572614,
0.0014707756,
0.009748377,
0.001321276,
-0.024948897,
0.00993546,
-0.006417626,
0.005325193,
0.013536815,
0.003524516,
-0.010416532,
0.016556874,
-0.0163297,
0.009608065,
-0.023372052,
-0.0037049178,
0.020539075,
0.00047981858,
0.0064076036,
-0.035786364,
-0.011639255,
0.003222176,
-0.013790713,
0.0030601486,
-0.005662611,
-0.0028146016,
0.016383152,
-0.016690504,
0.0014373678,
0.007510059,
-0.004052358,
-0.0022516814,
0.0275547,
0.005298467,
0.009668198,
-0.011084687,
0.03183089,
-0.00031173593,
-0.030307498,
0.026712826,
0.020017914,
-0.019924372,
-0.029960057,
-0.02685982,
-0.04099797,
-0.01416488,
0.0049977973,
0.02832976,
-0.014378689,
-0.006765066,
-0.02971952,
0.019015683,
0.021073598,
-0.011392037,
-0.004162604,
0.0037082585,
-0.006517849,
-0.022423271,
0.0051982435,
-0.1688026,
0.0047138315,
0.019189402,
-0.027287439,
0.033888806,
0.0012669883,
0.025550235,
-0.018775146,
0.016423242,
0.007055714,
0.027180534,
0.020098094,
-0.024387646,
-0.022877617,
0.008953273,
0.0018040177,
-0.01861479,
0.024775177,
0.014592499,
0.014111428,
0.021955563,
-0.015407647,
0.021527944,
-0.00012381742,
-0.0030935563,
0.013630356,
-0.031216187,
-0.037523568,
0.0016678812,
-0.010610296,
-0.007109166,
0.016516784,
0.014712767,
-0.005351919,
0.034583688,
-0.013723898,
0.01191988,
0.0065412344,
-0.014699403,
0.007510059,
0.025991218,
0.02012482,
0.011605848,
-0.01774619,
-0.010276219,
0.0010865866,
0.016864225,
-0.00024178848,
0.0116593,
-0.01973729,
0.02470836,
-0.009688243,
0.019229492,
0.0038318671,
0.002625848,
0.013830802,
0.0070022615,
0.007022306,
0.012541263,
-0.00539869,
-0.005726086,
-0.004897574,
0.020579165,
-0.013964433,
-0.008899821,
-0.033487912,
0.0032355392,
-0.001822392,
-0.027421068,
0.007937678,
-0.013490044,
-0.004032314,
0.018160446,
-0.018708332,
0.010343035,
0.01282857,
-0.01109805,
-0.0049610487,
0.009307395,
0.011559077,
-0.013964433,
0.0075301034,
-0.014712767,
-0.01977738,
-0.020071367,
0.006855267,
0.004720513,
0.011138139,
0.0039621573,
0.0016962778,
0.00842543,
-0.018320803,
0.012193823,
-0.016864225,
0.003222176,
0.03386208,
-0.020752884,
-0.0017956657,
-0.003631421,
-0.00418933,
0.014579136,
-0.01127177,
-0.0053084893,
0.01524729,
0.03239214,
0.011672663,
-0.001243603,
0.00855238,
0.05377309,
0.0059398953,
-0.019590296,
0.0026926633,
0.00742988,
0.01762592,
-0.018000087,
0.028597021,
0.0030217296,
0.0032539135,
-0.007476651,
-0.023104789,
0.055055946,
0.016543511,
0.010790698,
0.017291844,
0.016316338,
-0.041345414,
-0.123581894,
-0.027741782,
0.015768452,
0.010717201,
-0.019162677,
0.00932744,
0.010276219,
0.0029315287,
-0.0063942405,
0.04220065,
0.0027862052,
-0.01563482,
-0.0009988913,
0.0014833035,
0.02379967,
-0.0024537982,
0.030681664,
-0.019015683,
-0.00038189217,
0.044151664,
-0.0052550365,
0.018588064,
0.0057160635,
-0.007610282,
0.0029833107,
-0.001291209,
-0.036160532,
0.0177061,
0.0149132125,
0.015888719,
0.003614717,
-0.00032217585,
0.016877588,
-0.0065713017,
-0.02881083,
-0.005014501,
-0.013723898,
-0.031750713,
0.037149403,
0.0032772988,
0.009420982,
0.015835267,
0.024387646,
-0.00084730366,
0.00018384695,
-0.018200533,
-0.008966636,
0.01109805,
0.03070839,
-0.016249523,
-0.020311903,
-0.019750653,
-0.016222795,
-0.002699345,
0.011766205,
-0.025282973,
-0.00030860395,
0.020245088,
0.009714969,
-0.024521278,
0.0028413278,
-0.024387646,
0.0067182956,
0.0049142777,
0.011579121,
-0.012721665,
-0.00076169637,
-0.035519104,
0.018628154,
-0.0010339695,
-0.0012118656,
-0.01973729,
-0.00976174,
0.000660638,
-0.01836089,
-0.028730651,
-0.013443273,
-0.00850561,
-0.0038752973,
-0.014632588,
-0.004252805,
-0.01844107,
0.022383183,
-0.016075803,
0.016262885,
-0.0048173955,
0.014098064,
0.003420952,
0.013657082,
-0.015701635,
-0.023425505,
0.01822726,
-0.01347668,
-0.008686011,
-0.009915416,
-0.0031754053,
0.008238347,
-0.019323034,
-0.0006907049,
0.02414711,
-0.020592527,
-0.010309627,
-0.057033684,
0.023919938,
0.008398704,
-0.018681606,
0.0054387795,
-0.005238333,
0.003895342,
-0.0030000147,
-0.0039120456,
0.007844136,
-0.026512379,
0.010383124,
-0.016383152,
0.014298511,
-0.0151671115,
-0.008017857,
0.016209433,
-0.015888719,
-0.009233898,
0.010864195,
0.0030768523,
-0.014138154,
0.014392052,
-0.013282916,
-0.0019510117,
-0.0153274685,
-0.029291902,
0.02776851,
-0.012227231,
0.0036347616,
0.0153274685,
-0.024387646,
-0.009407618,
0.0067349994,
-0.007523422,
-0.006701592,
-0.007964404,
0.02647229,
0.011819657,
0.022289641,
-0.01952348,
-0.049096007,
0.0061136154,
-0.01139872,
-0.0069354456,
0.011305178,
-0.016743956,
-0.009547931,
-0.025617052,
0.021233957,
0.0239333,
0.005826309,
-0.022516813,
-0.0075434665,
-0.018494522,
-0.022035742,
0.003718281,
-0.023652676,
-0.024133747,
-0.014325237,
0.020913241,
0.01818717,
0.0024287424,
0.0093942555,
-0.007302931,
-0.01183302,
-0.04810714,
-0.01105796,
-0.012661532,
-0.030895473,
-0.028196128,
0.008438794,
-0.0031152712,
0.012694939,
0.01749229,
-0.01710476,
-0.021474492,
-0.015728362,
0.008679329,
0.013316323,
0.028784104,
0.0010799051,
-0.021715028,
-0.007182663,
0.009527886,
0.0014106416,
0.0073697465,
0.012801844,
0.008031219,
0.0015985601,
0.0030050257,
0.019683838,
0.0046536974,
0.016289612,
0.010857514,
0.012120326,
-0.0056960187,
-0.028677199,
0.008051264,
0.02043217,
-0.002383642,
-0.013610311,
0.012922112,
-0.0067884517,
0.004981093,
0.012287365,
-0.034957852,
-0.04145232,
-0.019122588,
-0.004854144,
0.0031737348,
0.013363094,
0.010530118,
0.0022967819,
0.005739449,
0.02747452,
0.030467855,
0.013008972,
-0.01071052,
0.044980176,
0.020886516,
0.028757378,
-0.0037249625,
-0.00003502592,
0.011826338,
-0.022476723,
0.031804163,
-0.045755234,
0.04452583,
-0.015314106,
0.015568005,
-0.0020078048,
-0.037256308,
0.0038418896,
-0.005739449,
-0.010002276,
0.0025673844,
-0.00781741,
-0.019376487,
0.09402273,
0.012073555,
-0.0049243,
-0.008478883,
-0.020833064,
0.01528738,
0.011652618,
0.010951055,
-0.020792974,
-0.020672707,
-0.00011076752,
-0.018935503,
0.029772973,
-0.010008957,
-0.028837558,
0.016423242,
0.0017990065,
0.002517273,
-0.0045634964,
-0.013897618,
0.01123168,
0.002051235,
-0.0066648433,
0.019857557,
-0.026205027,
-0.0061303196,
0.03370172,
0.007216071,
0.000628483,
-0.06579988,
0.00053285336,
0.0016403198,
-0.04073071,
-0.013596948,
0.0056592706,
-0.019202767,
0.0069287643,
-0.010383124,
0.021715028,
0.009581339,
0.007490014,
0.007596919,
-0.010109181,
-0.046663925,
0.012461085,
-0.008305163,
-0.0057461304,
0.0038418896,
-0.007670416
] |
OBJECTIVES To examine trends in life expectancy at birth and age and cause specific patterns of mortality in the former German Democratic Republic (GDR) and Poland during political transition and throughout the 1990s in both parts of Germany and in Poland. METHODS Decomposition of life expectancy by age and cause of death. Changes in life expectancy during transition by cause of death were examined using data for 1988/89 and 1990/91 for the former GDR and Poland; examination of life expectancy changes after transition were based on 1992-97 data for Germany and 1991-96 data for Poland. RESULTS In both the
|
[
0.010240163,
-0.00923455,
0.010785691,
-0.045587786,
-0.0009768576,
0.015511415,
-0.021755418,
0.011975339,
-0.030707344,
-0.014630682,
0.0050872182,
0.037595462,
0.0032403083,
0.01220538,
-0.0030661335,
0.015682304,
0.025725288,
-0.011515254,
0.016129242,
-0.017877564,
-0.014499229,
0.013815676,
-0.00071230915,
0.008781038,
0.009208259,
0.00172203,
0.018087888,
-0.030654762,
0.0076505453,
0.007959459,
0.00375626,
-0.015090766,
-0.03586029,
-0.02530464,
-0.017851273,
-0.015182784,
-0.011995056,
-0.004308361,
0.003029984,
-0.010739683,
-0.0066317874,
0.0071050166,
0.0040290244,
0.001536353,
0.010660811,
0.018403374,
-0.009043944,
-0.018311357,
-0.0006313836,
0.002180471,
0.005655751,
0.031785257,
-0.01888975,
-0.018732006,
0.0020210848,
-0.018377082,
0.007519093,
0.0030677768,
0.002469667,
-0.0040848916,
-0.019520722,
0.008925636,
-0.018784586,
0.0053895595,
-0.03189042,
-0.011436382,
-0.018166758,
0.026461422,
0.009221405,
-0.00039271486,
0.047612157,
0.021847434,
0.02393753,
0.024213582,
0.027578771,
-0.00885991,
-0.0046862876,
0.014407213,
-0.016431583,
0.0072101788,
0.017575221,
-0.0075059473,
-0.0018403374,
0.02613279,
0.012954661,
-0.008669304,
-0.023674626,
0.024226727,
0.010062702,
-0.009076807,
0.010062702,
0.009181969,
0.014341487,
0.034861248,
-0.00838668,
-0.0048275995,
-0.0039468664,
0.026947798,
-0.0024203723,
-0.031206863,
-0.023030508,
0.000015340423,
0.003246881,
-0.0015626436,
-0.030838797,
0.0023710774,
-0.0023940818,
-0.020769522,
0.0037003926,
-0.015130202,
-0.016615618,
0.0438789,
0.021610819,
-0.023398574,
-0.010733111,
-0.018363938,
0.011199768,
-0.01330301,
-0.011758441,
-0.028104581,
0.018824022,
-0.0010335466,
0.038594503,
-0.035728835,
-0.00041530828,
-0.004636993,
-0.023293413,
0.010075848,
-0.00626372,
-0.00019399538,
-0.014459793,
-0.00070039625,
-0.0072956234,
0.003910717,
-0.014026,
0.009379148,
-0.016010934,
-0.01120634,
-0.0073087686,
-0.034388017,
0.018626843,
0.0025041734,
0.010989443,
-0.018009016,
0.0026027628,
0.030181533,
0.020204276,
0.01752264,
0.0034604915,
-0.0016793079,
0.009911532,
-0.017364897,
0.010772547,
-0.010325607,
0.008163211,
0.02318825,
0.027946837,
0.018955475,
-0.028709263,
-0.010976298,
-0.0089913625,
0.008104057,
-0.001349033,
0.015182784,
0.0013276719,
0.027631352,
-0.01727288,
0.0046468517,
0.016326422,
0.014551811,
-0.0065627745,
0.033283815,
-0.040277097,
0.031338315,
0.0120936455,
0.014762135,
-0.014170598,
0.021426786,
-0.041907113,
-0.018981766,
0.007893733,
0.013454181,
0.027789094,
0.028604101,
-0.0109500075,
-0.0035886578,
0.011613843,
0.019362979,
-0.011771587,
-0.005770772,
0.00061823835,
0.026684891,
-0.0052646794,
-0.021006137,
-0.64864004,
-0.023595754,
-0.009333139,
-0.01480157,
0.013230711,
0.016523601,
-0.00021874545,
0.03399366,
-0.037832078,
0.03983016,
-0.0009711066,
0.021610819,
0.022938492,
-0.016379002,
-0.019297251,
-0.02021742,
-0.011515254,
0.016733926,
0.03199558,
0.027184412,
-0.015734885,
-0.0077688526,
0.01135751,
0.036333516,
-0.021847434,
0.04574553,
0.031233154,
-0.007729417,
0.018390229,
0.03344156,
-0.010411051,
0.012764054,
-0.0028360914,
0.019625884,
0.044615038,
-0.016681343,
-0.007966032,
0.018679425,
-0.0031795115,
0.027210703,
-0.012980951,
-0.007874015,
0.0216634,
0.011022306,
0.0030776355,
0.011620416,
0.009050516,
0.019783627,
0.0046238475,
-0.01142981,
0.014709554,
0.013414745,
0.0047224374,
0.024187291,
0.003496641,
0.01674707,
0.0057937764,
-0.011318075,
0.00184691,
-0.014762135,
0.0058266395,
0.004998488,
-0.0032830304,
-0.001712171,
-0.04485165,
0.026185371,
-0.017838128,
0.03260026,
-0.013105831,
0.0018518395,
0.0064674714,
0.038226437,
-0.0033471137,
-0.028682973,
0.03338898,
0.012290824,
0.015419398,
-0.002749004,
0.00023127453,
0.010115283,
0.015222219,
0.0069144103,
-0.025567545,
0.009812942,
0.031627513,
-0.029734595,
-0.025396656,
0.010877709,
-0.010805409,
0.017496351,
0.00075585285,
0.0034374874,
-0.0016973827,
0.0054027047,
0.017062556,
0.01874515,
-0.0071575977,
-0.0105425045,
0.008406398,
-0.023069944,
-0.0052055256,
-0.0018797732,
0.011291784,
0.012146227,
-0.01130493,
0.026895216,
-0.031180574,
-0.004512113,
0.04285357,
-0.022964781,
0.0058233533,
-0.009030798,
0.01158098,
-0.015458834,
0.0017926858,
-0.023122525,
0.0146043915,
0.0021919734,
-0.0021854006,
-0.026763763,
0.024726247,
-0.021203315,
0.033730756,
-0.030365568,
0.01499875,
0.031732675,
0.011488963,
0.004607416,
-0.000060848208,
-0.0103584705,
0.01267861,
0.012448568,
0.019060638,
-0.0039402936,
0.014578101,
-0.013086113,
0.016852232,
-0.023017362,
-0.010825127,
-0.008570714,
-0.022583568,
0.008794184,
-0.006017246,
-0.018022161,
-0.002262629,
-0.0048078815,
-0.016825942,
-0.016010934,
0.0033602589,
-0.0048801806,
-0.0031302166,
-0.0046468517,
0.010627949,
-0.00069957465,
-0.01821934,
-0.013184703,
-0.0010442272,
-0.0014804857,
-0.033152364,
0.016457874,
0.013881402,
0.0063655954,
-0.03940951,
0.013723658,
0.0048834668,
-0.022530988,
-0.008472125,
0.027631352,
0.004160477,
-0.023319704,
-0.010680529,
0.0027736514,
-0.0066054966,
-0.013125549,
-0.009444875,
-0.0010105424,
-0.0044956813,
-0.0029330377,
0.016457874,
-0.01874515,
0.026343115,
-0.012244816,
-0.022964781,
-0.01699683,
0.034756087,
0.013414745,
0.0041374727,
0.005074073,
-0.007834579,
0.028052,
0.006181562,
0.041223556,
-0.016102953,
0.01265232,
-0.010476778,
0.012593166,
-0.0072233244,
0.007459939,
0.018232485,
0.016931104,
0.028893298,
-0.034887537,
0.019980805,
-0.004525258,
0.018758295,
0.011659852,
-0.0069998545,
-0.018009016,
0.003072706,
0.02760506,
0.0034309146,
-0.025028588,
-0.02113759,
-0.008616722,
-0.013907692,
0.016576182,
-0.029918628,
-0.0009004508,
-0.01694425,
0.008189501,
0.007335059,
0.008498415,
0.019928224,
-0.011719005,
-0.019073782,
0.00876132,
0.0032731714,
0.017391188,
0.019560156,
-0.03649126,
-0.008564142,
0.016484166,
0.024200436,
0.014012855,
0.017180864,
0.007880587,
0.0038318452,
-0.0070064273,
0.028814426,
0.015550851,
-0.016076662,
0.0026701323,
0.00008600907,
-0.005527585,
-0.028341196,
-0.022544133,
0.023030508,
0.01477528,
-0.038988862,
0.015642868,
-0.012560302,
0.012757482,
-0.001095165,
-0.024989152,
0.019100074,
-0.01991508,
0.015826901,
0.0031975862,
0.017627804,
0.04432584,
0.025462382,
0.0027243565,
0.015471979,
-0.0011830741,
-0.014210033,
0.0047454415,
-0.0248577,
-0.0053566964,
-0.0075782463,
-0.013710514,
-0.0172203,
-0.00898479,
0.014407213,
-0.03399366,
0.007499375,
-0.009241123,
0.0056919004,
-0.008577286,
-0.01095658,
0.0077557075,
-0.01624755,
0.0036083758,
0.021466222,
0.03354672,
-0.0063557364,
-0.021834288,
-0.0074862298,
-0.00017602334,
-0.026737474,
0.013197848,
-0.0038647086,
-0.0018797732,
0.007374495,
0.016037226,
-0.0055341576,
-0.014722699,
-0.0018124037,
-0.0073942128,
0.019783627,
0.0008187037,
0.010259881,
0.0011855387,
-0.014144307,
-0.0088073285,
0.017982725,
0.00985895,
-0.013072968,
-0.020125404,
0.01894233,
0.009589472,
-0.016102953,
-0.011423237,
-0.02338543,
-0.000018292974,
-0.0027210703,
-0.0035952306,
-0.024463343,
-0.000008048909,
0.012389414,
0.012540584,
-0.007643973,
-0.01330301,
-0.021347914,
-0.015866337,
0.07009056,
0.043589704,
0.016957395,
0.0028147304,
-0.0021837575,
0.005106936,
0.016904814,
-0.023122525,
0.023175105,
0.03352043,
0.007966032,
-0.02113759,
0.0128692165,
-0.0073087686,
0.015958354,
-0.0018058311,
0.01155469,
-0.02363519,
-0.015064476,
0.019362979,
-0.013342446,
-0.010752829,
0.025843594,
0.051608317,
-0.0020293007,
0.012790345,
0.020822102,
0.0015642868,
0.015366817,
0.0020210848,
-0.02563327,
0.009648626,
-0.023990111,
0.032863166,
-0.014302051,
0.034782376,
0.031785257,
-0.0004379017,
0.0130532505,
-0.0031910136,
0.0077688526,
-0.008399826,
-0.008176356,
-0.010936862,
0.037306268,
-0.022084048,
-0.024529068,
0.021807998,
-0.0063425913,
-0.021992031,
0.03302091,
-0.0046107024,
-0.0051956666,
-0.028341196,
0.0072101788,
-0.013118977,
0.015656013,
-0.012165945,
-0.008393253,
0.010470205,
0.0011912899,
-0.032810587,
0.013710514,
-0.0038712812,
0.009898386,
0.0016612331,
-0.049058136,
0.010871136,
-0.024542214,
-0.013671078,
-0.018758295,
-0.021834288,
-0.0011608914,
0.005688614,
-0.00788716,
0.0076111094,
0.031154282,
-0.031180574,
-0.012468286,
-0.015143348,
-0.0058660754,
-0.023345994,
-0.013973419,
-0.012934943,
0.0048013087,
-0.006276865,
-0.013072968,
-0.031811547,
-0.035150442,
0.022491552,
-0.0013810747,
-0.008202647,
-0.014144307,
-0.013007241,
-0.011791305,
0.0073087686,
0.01672078,
0.0388837,
-0.0005097899,
-0.0007246328,
0.0034736367,
-0.009333139,
-0.023963822,
-0.02638255,
-0.0058923657,
-0.0018863458,
-0.012323688,
-0.0014377636,
0.00425578,
-0.004781591,
0.01342789,
-0.016352711,
0.014683263,
0.011173477,
0.033152364,
0.01155469,
0.010003548,
0.022754457,
0.018166758,
-0.018114178,
-0.0040947506,
0.0029396103,
0.027184412,
0.012954661,
-0.012488004,
0.0072430423,
-0.0018814163,
-0.007939741,
-0.039882742,
-0.018784586,
-0.0017729679,
0.005106936,
0.014867297,
-0.029208783,
0.0111340415,
0.018179905,
-0.011009161,
0.024831409,
0.0070590083,
-0.02094041,
-0.01944185,
0.009918104,
-0.012001629,
-0.017706675,
0.031837836,
-0.02710554,
-0.0048407447,
-0.015209074,
-0.0024351608,
0.006122408,
-0.005455286,
-0.016234405,
-0.015892629,
0.026698038,
-0.008176356,
-0.025409801,
0.003785837,
-0.008458979,
0.02685578,
-0.00014244129,
0.032810587,
0.020532908,
0.02163711,
0.024897136,
0.0072430423,
0.008117203,
0.014630682,
0.019652175,
-0.0012093646,
0.01716772,
0.014551811,
-0.0012348335,
-0.01819305,
-0.013763094,
0.013164985,
-0.014131162,
-0.010963153,
-0.020559197,
-0.002893602,
-0.053843014,
0.005031351,
0.009688062,
-0.010200727,
0.012606311,
-0.040277097,
-0.0040520285,
0.018022161,
0.006993282,
-0.011502109,
0.00034177693,
0.010443915,
-0.008570714,
0.043484543,
0.015734885,
-0.014959314,
0.00093742186,
-0.026421987,
-0.010476778,
-0.0012159372,
-0.021295333,
0.008932209,
0.012967806,
-0.003953439,
-0.017903853,
0.023345994,
-0.010325607,
-0.027026668,
-0.020151695,
-0.01265232,
-0.014814716,
0.0071773157,
-0.01452552,
-0.0095828995,
-0.025725288,
-0.01001012,
0.009214832,
0.0052876836,
0.021163879,
-0.011653279,
-0.047638446,
-0.0037891231,
-0.01352648,
0.006184848,
0.0023612187,
0.02480512,
0.0059186565,
-0.052817684,
-0.0274999,
0.009773506,
0.009050516,
0.0032452377,
0.008919064,
0.013684223,
-0.01070682,
-0.010443915,
-0.010555649,
0.013920838,
-0.0052876836,
-0.028998459,
0.025975049,
-0.0059810965,
0.009550037,
0.00040832485,
0.009845805,
-0.039094023,
0.0066416464,
-0.013454181,
-0.019704755,
0.02094041,
-0.01694425,
-0.0011617129,
0.008025185,
-0.04440471,
0.011876749,
0.00042064855,
-0.014656973,
0.008281518,
-0.029971208,
-0.008577286,
0.03727998,
-0.009142533,
0.0030316273,
-0.0022741312,
0.007446794,
-0.0063524502,
-0.0057444815,
-0.0128692165,
-0.008623295,
-0.019021202,
0.033757046,
-0.016024081,
-0.022294372,
-0.011442955,
0.0019685037,
0.0041769086,
0.005619602,
-0.020033387,
0.0037924096,
-0.013309583,
-0.011830741,
0.003414483,
0.011042024,
-0.025948757,
-0.008406398,
-0.032179613,
-0.009898386,
-0.0006100226,
-0.017654093,
0.018732006,
-0.014630682,
-0.0177724,
0.001110775,
-0.00247131,
0.006953846,
-0.005123368,
-0.01505133,
0.0027046388,
0.03049702,
-0.018508537,
0.014630682,
0.03599174,
-0.006421463,
-0.0013597136,
0.0197179,
-0.031154282,
-0.0015010252,
0.021466222,
0.01752264,
-0.01824563,
-0.01255373,
-0.00629001,
0.011377228,
0.016129242,
-0.017746111,
0.019836208,
0.010102138,
0.002218264,
-0.024529068,
-0.010516213,
0.023280269,
0.0033750474,
0.022833329,
0.007551956,
-0.008314381,
0.013933983,
-0.017391188,
0.0060205325,
0.019362979,
-0.02141364,
-0.0053106877,
-0.02211034,
0.033231236,
-0.008150065,
0.017798692,
-0.015629722,
-0.014433503,
-0.022084048,
0.030312985,
0.001415581,
0.007335059,
0.0015215647,
0.008314381,
-0.01098287,
0.016523601,
0.0041736225,
-0.009208259,
0.009648626,
0.0015215647,
-0.005343551,
0.0074139307,
-0.00858386,
0.03646497,
0.025199477,
-0.009201687,
-0.016076662,
-0.015866337,
-0.052975427,
0.010187582,
-0.0070590083,
0.02677691,
0.030418148,
0.035203025,
-0.0028048714,
0.017338607,
-0.0009160608,
0.008209219,
-0.027841676,
-0.032547683,
0.03136461,
-0.008912491,
0.038226437,
-0.0042097718,
-0.014065436,
-0.008044903,
0.021045573,
-0.013841966,
-0.009661771,
0.02099299,
-0.016641907,
-0.0077819983,
-0.006027105,
-0.007696554,
-0.016352711,
0.0029889052,
-0.013671078,
-0.03727998,
0.011640134,
0.008675876,
0.0018748437,
-0.0021098154,
-0.017207155,
-0.01694425,
-0.018009016,
-0.011160332,
-0.002469667,
0.0011691072,
-0.0042064856,
-0.028236033,
0.02188687,
0.03312607,
0.009037371,
0.020375164,
0.0111143235,
0.009720925,
-0.023700917,
0.0030069798,
-0.014328341,
-0.0111143235,
-0.0017795406,
0.015682304,
0.01996766,
-0.013973419,
0.021255897,
-0.012264534,
0.0039370074,
-0.034256566,
-0.0146043915,
-0.007571674,
0.01799587,
0.020007096,
0.0042064856,
0.022031467,
0.0065069073,
-0.016457874,
-0.0051693763,
-0.013736804,
0.00045926275,
-0.01844281,
-0.015642868,
-0.00029700086,
-0.009674917,
0.017562076,
-0.0045942706,
-0.018771442,
-0.012336833,
0.013565916,
0.17562076,
-0.022872765,
0.0034111969,
0.007959459,
-0.0041374727,
-0.0026241238,
0.029366527,
-0.0064773303,
0.0027473608,
0.021255897,
-0.02652715,
0.011672997,
0.0011649993,
0.0071181622,
0.0044463864,
-0.02343801,
-0.0374903,
0.00485389,
-0.010713393,
0.021032427,
-0.007926596,
-0.012593166,
-0.014722699,
0.00572805,
0.004025738,
-0.0066580777,
-0.002832805,
0.016484166,
0.020532908,
0.003174582,
-0.005780631,
-0.040277097,
-0.0052745384,
0.0011017377,
-0.017404333,
-0.005547303,
0.0015831831,
-0.050556697,
0.022084048,
-0.00898479,
0.014551811,
0.009563182,
-0.0113377925,
-0.004420096,
0.0134016,
0.043668576,
-0.004213058,
-0.015511415,
-0.016326422,
-0.0097669335,
-0.046481665,
-0.009135961,
-0.00038737457,
0.025712142,
0.0035623673,
0.026500858,
0.017009975,
-0.0071838885,
-0.0039501525,
0.0029001746,
0.005028065,
0.0058857934,
-0.038568214,
0.010023266,
-0.0009538534,
0.02168969,
0.0019586447,
0.004867035,
0.013289865,
-0.03691191,
0.0071510253,
-0.011916185,
-0.015642868,
0.014762135,
-0.011127468,
-0.013224139,
0.039619833,
0.033730756,
0.024016403,
0.027894257,
-0.024068983,
-0.017562076,
-0.007867442,
-0.007624255,
-0.024239872,
-0.018285066,
0.011390374,
0.020085968,
-0.023622045,
0.00425578,
-0.007282478,
-0.01821934,
-0.0011296713,
0.010529359,
0.020072823,
0.001540461,
-0.00425578,
0.022281228,
-0.007920023,
-0.019270962,
-0.012829781,
0.07240413,
0.02677691,
-0.00616513,
-0.0041243276,
0.0040060203,
-0.023464302,
0.04435213,
0.0005455286,
-0.03207445,
0.0007127199,
-0.005997528,
0.012711473,
-0.016273841,
0.01008242,
0.011272066,
0.019941371,
-0.009181969,
0.009674917,
-0.019796772,
-0.018613698,
-0.04840087,
0.0032403083,
0.02685578,
-0.018298212,
-0.01205421,
-0.016786506,
-0.026264243,
-0.019165799,
-0.019100074,
0.008590432,
-0.047480706,
-0.0048801806,
-0.012980951,
-0.009096525,
0.0036346663,
-0.0053402646,
-0.0033536863,
-0.012139654,
0.003112142,
0.0070787263,
-0.020506617,
-0.0021755416,
-0.018363938,
0.005583452,
0.006756667,
0.001068053,
0.01524851,
-0.02138735,
-0.0077359895,
-0.014394067,
-0.019034347,
0.012796917,
-0.010910572,
0.014118017,
-0.0034473464,
-0.04393148,
-0.028104581,
0.01502504,
0.020125404,
-0.014880442,
0.010713393,
0.026619166,
-0.015787465,
-0.0014476225,
0.0045088264,
-0.16615617,
0.031180574,
0.0094185835,
-0.023227686,
0.017575221,
-0.016707635,
0.020677505,
0.00036026246,
0.0003193889,
0.0060731135,
0.008504988,
0.036701586,
-0.039593544,
-0.031837836,
-0.011719005,
-0.0029954778,
-0.0017072415,
0.045508914,
0.011725578,
0.012954661,
0.032942038,
-0.006815821,
0.015209074,
0.0065496294,
-0.0034736367,
0.021623963,
0.01130493,
0.015064476,
-0.002145965,
-0.010483351,
-0.03938322,
0.0023431438,
0.022938492,
0.004982056,
-0.056261744,
0.010575367,
-0.011482391,
-0.014827861,
-0.01008242,
0.00032657772,
0.024068983,
0.011561262,
-0.0013597136,
0.0049031847,
0.007282478,
0.009122815,
0.0039140033,
-0.015471979,
0.032284778,
-0.005014919,
0.019297251,
-0.025028588,
0.013487044,
-0.003848277,
-0.0023694343,
-0.021860579,
0.020585489,
-0.00012364767,
-0.0023053512,
0.025173187,
-0.016392147,
-0.0036576705,
0.017325463,
0.014328341,
0.010798837,
-0.0039238622,
-0.02897217,
0.007959459,
-0.027631352,
-0.016129242,
-0.018771442,
0.0040947506,
0.008084339,
-0.01330301,
0.0363861,
0.012152799,
-0.026303679,
-0.037542883,
0.008820474,
-0.00041777303,
-0.010529359,
0.037148524,
-0.006713945,
-0.0040553147,
-0.027920548,
-0.00085772865,
0.011252348,
0.025659561,
-0.015090766,
-0.025094315,
0.0088270465,
-0.011160332,
0.0019652175,
-0.018916039,
-0.0045712665,
0.020835249,
-0.018311357,
-0.016063517,
0.0140522905,
-0.0076834084,
0.019205235,
-0.02505488,
-0.02138735,
0.011876749,
0.019336687,
0.012632602,
-0.01205421,
0.0064083175,
0.030602181,
-0.00998383,
-0.004245921,
0.023306558,
-0.017824981,
0.010220445,
0.0033208232,
0.022333808,
0.0088862,
-0.0013038461,
0.013171557,
-0.00013514978,
0.043431964,
-0.016681343,
-0.008531278,
-0.017509496,
0.0055144397,
-0.006161844,
-0.10810667,
-0.008853338,
0.024555359,
0.018363938,
0.034992702,
0.0006860186,
-0.012185662,
0.010279599,
-0.008491842,
0.02608021,
-0.016576182,
0.00870874,
0.00042516724,
-0.020611778,
0.06020532,
-0.010115283,
0.011048597,
-0.026303679,
-0.008432689,
0.030681053,
-0.0010713392,
0.012290824,
0.0064148903,
-0.023030508,
-0.014078581,
-0.014196889,
-0.01913951,
0.009142533,
-0.003723397,
0.00040216302,
-0.0005919478,
-0.0076374,
0.018508537,
-0.016379002,
-0.0047125784,
-0.009773506,
-0.013342446,
-0.00009165743,
0.025068024,
-0.024870845,
0.007584819,
0.018114178,
0.0058496436,
-0.02505488,
0.011515254,
-0.021177026,
-0.0048177405,
0.034624632,
0.009024226,
-0.0033241094,
-0.020401454,
-0.00485389,
-0.016063517,
-0.0028590956,
0.002313567,
-0.018035306,
0.008787611,
-0.020979846,
0.0012192235,
0.00038675842,
-0.0018748437,
0.012080501,
-0.020730086,
0.002895245,
0.027920548,
-0.009727498,
-0.049925726,
-0.019402415,
-0.01747006,
-0.014670118,
-0.023069944,
0.013736804,
-0.0063557364,
0.0024335175,
-0.015853193,
-0.0035623673,
-0.004406951,
-0.0064904755,
0.013723658,
-0.013086113,
-0.006704086,
-0.019901935,
0.021926306,
-0.017338607,
0.006713945,
0.021715982,
0.006743522,
-0.030891377,
0.0150118945,
-0.013697368,
0.010923717,
0.047454413,
0.009694634,
-0.029261364,
0.016365858,
0.021505658,
-0.016878523,
-0.0065857787,
0.011850459,
0.008353817,
-0.026053919,
-0.025909321,
-0.05265994,
0.007867442,
0.004472677,
-0.018666279,
-0.013026959,
-0.009780078,
0.026067065,
-0.009326567,
0.01716772,
0.014039145,
-0.0149724595,
-0.003808841,
-0.027526189,
-0.021518802,
-0.016523601,
-0.042012274,
0.003205802,
0.030602181,
0.035281897,
0.028867006,
0.013171557,
0.009431729,
0.015511415,
-0.0007632471,
-0.02438447,
-0.015853193,
-0.0069472734,
-0.0027161408,
0.0003352043,
-0.014722699,
0.015642868,
-0.031785257,
-0.001593042,
-0.011725578,
-0.008130347,
-0.01966532,
-0.0011904682,
0.009517173,
0.03352043,
0.048032805,
-0.020519761,
-0.02143993,
0.009346285,
-0.03657013,
0.015761174,
-0.0058759344,
0.014762135,
-0.0034999272,
-0.0008848408,
0.01624755,
0.041723076,
-0.007453366,
-0.00019091446,
-0.006237429,
-0.0039041443,
0.0060468228,
0.006713945,
0.021150734,
0.0099509675,
-0.006401745,
0.032284778,
-0.020835249,
0.000284061,
-0.00090702344,
0.03996161,
-0.03996161,
-0.009280559,
-0.00566561,
-0.00579049,
-0.028656682,
-0.012764054,
0.022399535,
0.014814716,
0.03533448,
-0.0015322452,
-0.005501294,
-0.0134016,
0.012008201,
0.00063425914,
0.010936862,
0.004906471,
0.018311357,
-0.026921507,
0.02707925,
0.011252348,
0.026264243,
-0.022991072,
0.019205235,
-0.0072693327,
0.0021854006,
0.00017191544,
0.00535341,
0.0015913988,
-0.002458165,
-0.013723658,
-0.0017516068,
0.007604537,
-0.0052942564,
0.02441076,
-0.009819514,
-0.0022544132,
-0.0031729387,
-0.009839232,
-0.03596545,
-0.009688062,
0.019100074,
-0.019047491,
-0.038121276,
0.00021052967,
0.0059745237,
0.01630013,
0.019849353,
-0.043563414,
-0.004374088,
-0.009405439,
0.018508537,
-0.007315341,
-0.015590287,
-0.0007788571,
0.021400495,
0.0022692017,
0.011837313,
-0.007604537,
-0.013579061,
0.014762135,
0.00429193,
0.026106501,
0.0101744365,
0.011666425,
-0.013855112,
0.01888975,
-0.0066153556,
-0.012165945,
-0.015471979,
0.0067895306,
-0.0274999,
0.019008055,
0.025646416,
-0.0115218265,
0.06604182,
0.032573972,
-0.013631642,
0.008702166,
0.018048452,
0.023240833,
-0.005051069,
0.012757482,
-0.014617537,
-0.046008434,
0.019875644,
-0.020362018,
0.0045975572,
-0.015511415,
-0.00005278646,
0.010049556,
-0.008892773,
0.0072101788,
-0.0037201105,
-0.008150065,
0.011587553,
-0.009024226,
0.0010392977,
0.010148146,
-0.016418438,
-0.0034572051,
0.03738514,
-0.006007387,
0.015103912,
-0.006536484,
-0.011981911,
0.0012126509,
-0.023648335,
-0.0072101788,
-0.0014640541,
-0.028998459,
-0.002698066,
-0.02652715,
-0.002883743,
-0.006151985,
-0.0014739131,
0.006161844,
0.012218526,
-0.010871136,
-0.018035306,
-0.02260986,
0.009333139,
-0.012231671,
-0.0047355825
] |
CONTEXT For the last 40 yr, the first line of treatment for anovulation in infertile women has been clomiphene citrate (CC). CC is a safe, effective oral agent but is known to have relatively common antiestrogenic endometrial and cervical mucous side effects that could prevent pregnancy in the face of successful ovulation. In addition, there is a significant risk of multiple pregnancy with CC, compared with natural cycles. Because of these problems, we proposed the concept of aromatase inhibition as a new method of ovulation induction that could avoid many of the adverse effects of CC. The objective of
|
[
-0.042464726,
-0.0022449568,
-0.010334514,
-0.01377488,
0.009905306,
0.007879983,
-0.028595954,
-0.010757015,
-0.022546811,
-0.015397822,
0.012420194,
0.030822469,
-0.001370614,
0.008322603,
-0.021500617,
0.022171253,
0.044422984,
0.011132572,
-0.007812919,
0.005492516,
-0.030741993,
-0.0020856806,
-0.01671227,
0.0009246405,
-0.0030145126,
-0.0068371426,
0.016229412,
-0.051585384,
-0.0150625035,
0.020105692,
-0.010535705,
0.014888138,
-0.0062134503,
-0.027630238,
-0.03613391,
-0.01857664,
0.0013773204,
-0.0024528543,
0.006954504,
-0.014110199,
0.03964805,
-0.010300982,
0.000112646034,
0.017584099,
-0.007122163,
0.0017688046,
0.012507377,
0.002885415,
-0.017275605,
0.0030966655,
0.0059217233,
0.016967112,
-0.024250228,
0.0311712,
-0.006548769,
-0.0011593634,
-0.018898547,
0.026557218,
0.010153442,
-0.022023713,
-0.014324803,
0.012587854,
-0.015639251,
0.024706261,
-0.0013806736,
0.025886582,
-0.0045066797,
0.015129567,
0.0012079846,
0.0014485755,
0.016135523,
0.04072107,
-0.014525994,
0.011642256,
-0.0030430146,
-0.010126616,
-0.047105532,
-0.012587854,
-0.0027546408,
0.013352379,
0.033934224,
0.0040875315,
-0.006448173,
0.020601964,
0.0038896936,
0.029883577,
0.0190595,
0.009744354,
0.007155695,
-0.0022097484,
0.01215194,
0.011065508,
0.032673426,
0.02371372,
-0.02166157,
0.046273943,
0.016256237,
0.03033961,
0.0033598905,
-0.00830919,
0.01455282,
0.01117281,
0.0020555018,
-0.018442513,
-0.027764365,
-0.0024830329,
0.0016841368,
-0.001758745,
0.022680938,
-0.011528247,
0.0143918665,
0.052068245,
-0.009958957,
-0.014968614,
0.027871666,
-0.02033371,
0.004473148,
-0.014217501,
-0.014525994,
-0.003839396,
0.0011954102,
0.007859863,
0.023807608,
-0.0096705835,
0.00764526,
-0.0012691802,
-0.030446913,
-0.0032408526,
-0.019984977,
0.005757417,
-0.0018995788,
0.02435753,
-0.001342112,
0.0121184075,
-0.038011696,
0.015357584,
-0.016189173,
-0.017530447,
-0.005358388,
-0.01626965,
0.011367294,
0.034229305,
-0.010683245,
0.002783143,
-0.024277054,
0.002358965,
0.007900102,
0.0068170233,
0.006116208,
0.012252535,
-0.016309887,
-0.015800204,
0.01093138,
-0.0063241054,
0.006733194,
0.008738398,
0.017262192,
0.027657064,
-0.007980579,
-0.02940072,
0.015786791,
-0.0106027685,
0.0134798,
0.008537207,
0.005167257,
0.004617335,
0.009295027,
-0.010294275,
0.0031687592,
-0.011045389,
0.028488653,
0.012735394,
-0.016698858,
0.013332261,
-0.0023187269,
0.016162347,
-0.010770428,
0.0075647836,
-0.009006653,
-0.031734534,
-0.041284405,
0.012601267,
0.009663877,
-0.0111124525,
-0.015451473,
0.017087827,
-0.0033146227,
-0.011622136,
-0.024518482,
-0.0076117283,
-0.02740222,
0.023056494,
-0.008631096,
-0.0053785075,
-0.6330812,
-0.010763722,
-0.008356135,
-0.01891196,
0.024531895,
-0.0016321624,
0.016819572,
-0.00434908,
-0.0076251407,
0.000040762145,
-0.03946027,
0.014150437,
0.0000975567,
0.008979827,
0.019287515,
-0.027898492,
-0.017570686,
-0.023874672,
-0.00727641,
0.0026356028,
-0.0012054697,
-0.017745052,
-0.009221257,
0.010046139,
0.02186276,
-0.018026719,
0.01340603,
-0.0017067707,
-0.024840388,
0.020038629,
0.013841945,
0.040452816,
-0.02725468,
-0.009610225,
0.047534738,
0.010810666,
0.010314395,
0.014002897,
0.010669832,
0.042625677,
-0.029668974,
-0.0029893636,
0.011648962,
-0.003768979,
-0.013687698,
0.015357584,
0.00899324,
-0.00757149,
-0.0005268691,
0.0014443841,
0.0036281452,
0.0050700144,
-0.006488411,
0.013976072,
-0.010388165,
0.030125007,
0.011179516,
-0.024035625,
0.0011249933,
0.015800204,
-0.013117656,
0.00057716685,
-0.019300928,
-0.034390256,
-0.002540037,
0.00860427,
-0.03122485,
0.00082027266,
0.0012398398,
0.00025526114,
0.02112506,
0.035302322,
-0.004436263,
-0.022774827,
0.026074361,
0.01739632,
-0.006840496,
-0.0011861889,
-0.010649713,
0.012051344,
0.012044637,
-0.007913515,
-0.009194431,
-0.0036817961,
0.015786791,
-0.008356135,
-0.019153388,
-0.0018979022,
0.0017604217,
-0.010374752,
0.0053013843,
0.020239819,
0.004590509,
-0.030071355,
0.0018895193,
0.007853158,
0.016081871,
0.013788293,
0.0055562262,
-0.030232308,
-0.016390365,
-0.022560224,
-0.012507377,
0.016497666,
-0.00046064367,
0.007048393,
-0.02308332,
-0.009040184,
0.04444981,
-0.038762808,
-0.0067264875,
-0.021742046,
0.00039588532,
-0.042357422,
0.03219057,
-0.020132517,
-0.012641504,
0.011608724,
-0.0037019153,
-0.030741993,
0.022144428,
-0.00838296,
0.016444014,
-0.002967568,
-0.01078384,
-0.023217447,
0.014418692,
-0.01543806,
-0.03240517,
-0.0068371426,
0.022908954,
-0.014566232,
0.014727185,
-0.008342722,
0.022090778,
-0.00009006443,
0.021017758,
-0.013506626,
0.019917915,
-0.003058104,
-0.024196576,
-0.005311444,
0.0012976823,
0.003986936,
0.013734642,
-0.017771875,
-0.00012480133,
0.011642256,
-0.0128762275,
-0.002387467,
-0.020548312,
-0.015894093,
-0.012232416,
0.033987876,
-0.016229412,
-0.006595713,
-0.0033749798,
-0.04659585,
-0.02945437,
-0.021165298,
0.0021929825,
-0.011830034,
-0.008228714,
0.005569639,
0.0009766149,
0.0036918558,
-0.000016399166,
-0.012802457,
-0.009449273,
-0.0241161,
0.009020066,
-0.028783733,
0.0062402757,
0.0440206,
-0.011796502,
0.018348623,
-0.011159397,
-0.018496163,
-0.017463382,
-0.0038494554,
0.00073979626,
-0.029642148,
-0.012621385,
-0.007812919,
0.013788293,
-0.008906057,
0.037877567,
0.0065990663,
0.0027563174,
0.030902946,
-0.026946189,
0.02415634,
-0.020239819,
0.00024750692,
0.013064005,
-0.030420087,
0.011145984,
0.02910564,
0.008141532,
0.04101615,
0.036965504,
0.009375503,
0.021232363,
-0.0022080718,
0.01861688,
-0.021406727,
-0.00035501836,
0.0028552364,
0.033800095,
0.011374,
-0.015706316,
-0.0019465234,
-0.022613874,
-0.024773324,
0.0039433446,
0.02018617,
0.002112506,
-0.0017805408,
0.014485756,
0.0050331294,
-0.0220103,
-0.0017302431,
0.022989431,
0.0021343017,
-0.01229948,
0.036697246,
0.017275605,
-0.011514834,
0.010683245,
0.0001547704,
-0.010207092,
0.011970867,
-0.01813402,
-0.0021728633,
0.008758517,
-0.008436612,
0.015599012,
-0.01911315,
0.0340147,
0.0069477977,
0.0022416036,
0.006719781,
0.05729921,
0.005385214,
0.020642202,
0.0034671924,
0.039916303,
0.022318793,
0.03283438,
0.02323086,
0.010897849,
0.0037086217,
-0.024558721,
0.01370111,
-0.015545362,
-0.0062000374,
-0.012413488,
-0.0006199199,
0.030768817,
0.032619774,
0.018160846,
-0.016900048,
-0.002732845,
-0.0063442243,
0.0043591396,
0.022654112,
0.031707708,
0.0169537,
-0.00696121,
-0.016497666,
0.0031301975,
0.009865068,
0.0012037931,
-0.011420946,
0.009013359,
0.00079763867,
0.006756666,
0.02142014,
0.02690595,
0.0106363,
-0.013587102,
-0.04037234,
0.02563174,
0.020843392,
-0.008201889,
0.014579644,
-0.018066956,
0.0020152638,
0.017892592,
0.0067834915,
0.022654112,
0.0065320027,
0.0022449568,
0.0019515532,
-0.0122055905,
-0.005294678,
0.030259134,
-0.02524277,
0.023847846,
0.014002897,
0.0050599547,
-0.010569236,
0.0046005687,
0.009006653,
0.03146628,
-0.016041633,
0.01445893,
-0.028193573,
0.00005443685,
-0.022050539,
0.010676539,
-0.010575943,
-0.00092212565,
-0.006850555,
0.010844198,
0.005915017,
-0.0042686034,
0.0122055905,
-0.013117656,
-0.00845673,
0.024880627,
0.0059451954,
-0.0155721875,
0.0004451352,
0.012869521,
-0.0062000374,
-0.010656419,
0.00930844,
0.012943291,
0.025806105,
0.003571141,
-0.029025162,
0.026047535,
0.014432104,
-0.009912012,
0.010770428,
0.004033881,
-0.015505124,
0.011374,
0.019394817,
0.0013555248,
-0.0296958,
-0.0047682277,
0.0053650946,
-0.002692607,
0.010461935,
0.030205483,
0.032727078,
0.012956704,
-0.010622888,
0.025162295,
0.035516925,
-0.0059720213,
0.011876978,
-0.004204893,
0.012534202,
-0.0033649204,
0.030232308,
0.009040184,
-0.023485702,
0.0043457267,
-0.008114706,
-0.020883631,
-0.025108643,
0.0039969957,
0.033934224,
-0.0021024465,
0.0079068085,
-0.010394871,
-0.021876173,
0.03656312,
0.0050163637,
-0.011830034,
-0.021594506,
0.019153388,
0.00840308,
-0.016993938,
0.005660175,
-0.011662374,
0.02690595,
-0.02029347,
-0.010582649,
-0.009710821,
0.00877193,
-0.0090871295,
-0.049171094,
0.0021678335,
-0.006096089,
-0.009690702,
-0.02058855,
-0.016511079,
-0.022466334,
-0.010891142,
-0.0026976366,
-0.012165352,
-0.011769677,
-0.032324694,
0.012393368,
0.004640807,
0.032458823,
-0.001302712,
0.0038695745,
-0.016148934,
0.042223297,
-0.029159289,
-0.03283438,
-0.025457375,
-0.02773754,
-0.007544664,
-0.0055461666,
0.0035879072,
0.003279414,
-0.006806964,
0.006515237,
0.021755459,
-0.015196631,
0.0032827673,
-0.027522936,
-0.010260744,
0.01122646,
0.003193908,
0.019931328,
-0.0013530098,
-0.029025162,
-0.0035610816,
-0.009764472,
0.017315842,
-0.013660872,
-0.014472343,
0.0410698,
-0.006552122,
0.013271903,
-0.012172058,
-0.00351749,
0.0062000374,
0.0058848383,
-0.017128065,
-0.017034175,
-0.0059787272,
0.032753903,
-0.011119159,
0.03248565,
0.016967112,
-0.0063140457,
0.011997693,
-0.02121895,
0.040506463,
-0.009113954,
-0.013855357,
0.025497612,
0.013734642,
-0.01244702,
-0.02465261,
0.0029323595,
0.0012163676,
0.040989324,
-0.01078384,
-0.026664522,
-0.043993775,
-0.015397822,
-0.036294866,
-0.006387816,
-0.0043960246,
-0.0076117283,
-0.012239122,
-0.003041338,
-0.013949246,
-0.019542357,
0.021768872,
-0.02533666,
0.03425613,
0.0023053142,
-0.023579592,
0.00749772,
-0.0014896521,
0.0035577284,
-0.035865657,
-0.015397822,
-0.0047212834,
-0.040211383,
-0.018603466,
-0.03785074,
0.00906701,
0.020092279,
0.016967112,
-0.024974516,
-0.00029151744,
0.00569706,
0.007953753,
0.0013940863,
-0.010871023,
-0.0034537797,
-0.025068404,
0.036321692,
0.020870218,
-0.015035678,
0.02768389,
-0.022171253,
0.029910402,
0.01857664,
-0.028461827,
-0.022519985,
-0.010535705,
-0.026744997,
-0.015102741,
0.0033464779,
0.011327056,
0.0027395515,
-0.0022717824,
-0.005200789,
0.0233784,
0.028059445,
0.02430388,
-0.011870272,
0.017798701,
0.009717528,
-0.002885415,
-0.025283009,
-0.004033881,
-0.015759965,
-0.004292076,
0.0033431246,
0.006340871,
0.012192178,
0.0059083104,
0.02773754,
0.00419148,
-0.015934331,
-0.02430388,
0.032029614,
0.01401631,
0.009972369,
0.011863566,
-0.026396265,
-0.0241161,
-0.0019666424,
-0.008201889,
-0.030554214,
0.01710124,
0.020360535,
-0.002296931,
0.022117604,
-0.024424594,
0.0019716723,
0.024733087,
-0.0482322,
0.0077793873,
-0.026651109,
0.036053438,
-0.024773324,
0.0155856,
-0.0015860561,
-0.021178711,
-0.0087518105,
0.019099737,
0.02675841,
0.021701807,
0.016309887,
-0.022989431,
0.002466267,
0.0033766564,
-0.021299426,
-0.032029614,
0.007544664,
0.033290412,
-0.0033263587,
-0.006843849,
-0.02572563,
0.0126280915,
0.029642148,
0.006538709,
-0.0048922957,
-0.00531815,
0.008369547,
0.0038427492,
0.037421536,
-0.013855357,
0.009355384,
-0.014351629,
0.019005848,
-0.002075621,
-0.030795643,
0.0031503167,
0.00397017,
-0.012326305,
0.025256183,
0.006669483,
-0.002910564,
0.012239122,
0.009006653,
-0.015947744,
-0.023043081,
-0.025122056,
0.049519826,
0.025363484,
0.008832287,
0.019663071,
0.0061765653,
0.02121895,
-0.015089328,
-0.012661624,
-0.007819626,
-0.0021292719,
-0.014955201,
0.023284512,
0.021970063,
-0.042464726,
-0.0047078705,
-0.01416385,
0.018898547,
-0.019716723,
-0.016148934,
0.023767369,
-0.028274048,
0.0017822174,
0.0025752455,
-0.000540701,
0.019636247,
0.004627394,
-0.0026255432,
0.002211425,
0.01612211,
-0.008134825,
-0.0058144215,
0.0101802675,
0.008094586,
-0.010428403,
0.016886635,
-0.025283009,
-0.01999839,
-0.0031922313,
-0.015759965,
-0.025578089,
-0.0241161,
0.011367294,
0.0022684291,
0.0066560707,
-0.015022265,
0.045603305,
0.009388915,
0.0077592684,
-0.0050834273,
-0.035221845,
-0.0037890982,
-0.030822469,
-0.003695209,
0.04225012,
-0.007987285,
0.00030262486,
-0.0152368685,
0.018348623,
0.018791243,
-0.023767369,
0.006334165,
0.009013359,
-0.0014678563,
0.004919121,
-0.01543806,
0.0003508269,
-0.021500617,
-0.016752508,
0.0010990062,
-0.027120553,
-0.032217395,
-0.015531949,
0.013801706,
-0.000028921213,
0.009865068,
-0.011414239,
-0.0066292454,
-0.033505015,
-0.017932829,
-0.039862655,
-0.019609421,
-0.007142282,
0.02225173,
0.019958152,
-0.021111649,
-0.033048984,
-0.01252079,
-0.010495466,
-0.014365041,
-0.014244326,
0.0076586725,
0.009026771,
0.029266592,
0.023579592,
0.020400772,
0.012185471,
-0.011186223,
-0.021621332,
-0.01207817,
0.0149015505,
-0.0060558505,
0.053248566,
0.000030938365,
-0.041284405,
-0.017758463,
0.022050539,
-0.009268201,
0.0067298408,
0.018241322,
0.014566232,
0.012943291,
-0.012970116,
-0.012856108,
0.0023338161,
-0.0063945223,
-0.0023472288,
-0.021889586,
0.00599214,
0.0038829872,
-0.02352594,
-0.012091582,
-0.010207092,
-0.016242824,
-0.03337089,
0.0060223187,
-0.030473737,
-0.018147433,
0.0057037664,
-0.008248833,
0.010468641,
0.040855195,
-0.008295777,
-0.003916519,
-0.0035409625,
-0.0008424875,
-0.04013091,
-0.007048393,
-0.0059787272,
-0.0046307473,
0.010461935,
0.006988036,
-0.01724878,
-0.00606591,
0.03656312,
-0.02779119,
0.0020555018,
0.00823542,
-0.0018341917,
-0.019636247,
0.0020236466,
0.0014963584,
0.009757766,
-0.0045033265,
0.013761468,
-0.00899324,
0.005894898,
-0.011521541,
-0.012587854,
-0.029266592,
0.0009531426,
-0.0014636649,
-0.02862278,
0.023043081,
-0.017677987,
0.00269596,
0.0054723965,
0.013392618,
0.18230592,
0.028408177,
-0.016846398,
0.039513923,
0.00032693546,
-0.0017453324,
0.02749611,
0.004399378,
-0.014834487,
0.008228714,
0.036375344,
-0.010850904,
-0.013707817,
-0.001866047,
0.0143918665,
-0.03532915,
-0.01115269,
-0.013855357,
-0.008107999,
-0.01406996,
-0.004872177,
0.0053047375,
0.020669028,
-0.020199582,
0.013064005,
-0.004292076,
-0.0037052685,
-0.011528247,
0.030473737,
0.0050901338,
-0.019193627,
0.017074414,
0.01999839,
-0.0033649204,
0.006330812,
-0.002581952,
-0.009395622,
-0.014418692,
-0.027657064,
-0.004771581,
-0.010763722,
0.009496218,
-0.019783787,
0.003698562,
-0.0025065052,
0.03004453,
0.019824024,
-0.027871666,
-0.0030530742,
-0.010656419,
-0.02166157,
-0.006719781,
0.019542357,
0.017034175,
0.0025417136,
0.005858013,
0.029427545,
0.005173963,
-0.004764875,
0.011253286,
-0.012037931,
0.003353184,
0.0063106925,
0.023633242,
-0.011776383,
0.029722625,
-0.025068404,
-0.0085774455,
0.008584152,
0.020883631,
0.0056903535,
0.0041847737,
0.011085627,
0.0077257366,
-0.012353131,
-0.0091005415,
-0.015652664,
0.05161221,
0.01460647,
0.0028585894,
-0.012420194,
-0.009569988,
-0.008262246,
0.003021219,
-0.011306937,
-0.012835989,
0.02773754,
-0.00607597,
-0.02754976,
0.0057976553,
0.0017436558,
-0.0057607703,
-0.012480551,
0.0006295603,
0.02494769,
-0.010448522,
0.008027523,
-0.014083373,
-0.009301733,
0.015263694,
-0.03288803,
0.071784966,
0.005331563,
0.023056494,
-0.0133859115,
0.024961103,
-0.0150625035,
0.017409733,
-0.010287569,
0.010079672,
0.010790546,
-0.018536402,
0.016202586,
-0.021245776,
-0.020508075,
0.021299426,
0.0048319385,
-0.03307581,
0.019475294,
-0.0073702987,
-0.022077365,
-0.023244273,
-0.0023489054,
0.034175653,
-0.012286067,
-0.0043088417,
-0.0025450669,
-0.0062402757,
-0.0035812007,
-0.017557273,
-0.00051177974,
-0.016309887,
-0.009764472,
0.0091743115,
0.007886689,
0.008242127,
0.0009380533,
-0.011769677,
-0.007772681,
-0.0069813295,
0.0005750711,
0.0058479533,
0.016283063,
0.013184721,
0.007189227,
-0.004070766,
-0.007900102,
-0.004473148,
-0.036965504,
-0.01370111,
-0.0072227586,
-0.013714523,
0.007537958,
0.0018073663,
0.02690595,
-0.008121412,
-0.028220398,
-0.012051344,
0.015169805,
0.03028596,
-0.032512475,
-0.013727936,
0.0212726,
-0.007242878,
0.0024897393,
-0.017610922,
-0.16792746,
0.00606591,
-0.0013236695,
-0.029829927,
0.021031171,
0.015370997,
0.009737647,
-0.002038736,
-0.022037126,
-0.014673534,
0.023445465,
0.009221257,
-0.0066929557,
-0.013017061,
0.008107999,
0.015089328,
-0.027214443,
0.0035443157,
0.027066903,
0.008242127,
0.020950695,
-0.030393261,
0.0038360427,
-0.035221845,
0.009556575,
0.014633296,
0.0044194967,
-0.0024059096,
0.018549815,
-0.0008491939,
-0.011769677,
0.0014510904,
0.015424647,
-0.005938489,
0.009925425,
-0.01754386,
0.008765223,
-0.0024092628,
0.0017352728,
0.018294973,
0.01935458,
-0.008564033,
0.010884436,
0.016993938,
-0.03235152,
0.027710713,
-0.007605022,
-0.018898547,
0.028005794,
0.0016640177,
0.010401578,
0.01117281,
0.014660121,
0.010569236,
-0.009281614,
0.021540856,
0.015424647,
0.008543913,
0.014499169,
-0.01455282,
0.0032123504,
-0.007377005,
0.011870272,
-0.003032955,
0.013976072,
-0.018160846,
0.0020739443,
0.018415688,
-0.0063811094,
0.019730136,
-0.002457884,
-0.0020907104,
0.009221257,
-0.004255191,
0.035114545,
0.008443317,
-0.00043088416,
0.023297925,
0.018710768,
0.010589356,
-0.036321692,
-0.008061055,
-0.019810611,
-0.00862439,
0.0022432802,
-0.010099791,
0.008336016,
0.026248725,
-0.016980525,
-0.0015215073,
0.021339664,
-0.037877567,
-0.0050465423,
-0.034578037,
0.0019951446,
0.0039299317,
0.00696121,
0.014244326,
0.0009590107,
-0.028864209,
0.03135898,
-0.013010355,
-0.007021568,
-0.0030966655,
0.048795536,
-0.0029005043,
-0.010911262,
-0.010985032,
0.014338216,
-0.0062503354,
-0.013486506,
-0.00074314943,
0.01588068,
0.0283277,
-0.013064005,
0.020803155,
0.016993938,
-0.013271903,
-0.002868649,
-0.0226407,
0.066580825,
0.0064179944,
-0.008517087,
-0.006186625,
-0.017087827,
-0.008389667,
-0.1362734,
-0.012252535,
0.021742046,
0.022841891,
-0.029078813,
0.017999893,
-0.010824079,
0.032512475,
-0.020615377,
0.029132465,
-0.020280058,
-0.017919416,
-0.0033481545,
0.0074306563,
0.021232363,
-0.004238425,
-0.018844895,
-0.021084823,
-0.032512475,
0.02710714,
0.014807661,
-0.019005848,
0.0072026397,
-0.022560224,
-0.016832985,
-0.0015114477,
0.0038829872,
0.029373894,
0.010401578,
0.0036616772,
0.0021242423,
0.015210044,
0.011085627,
0.0049794787,
-0.01940823,
-0.035409626,
-0.017154891,
-0.0042585437,
0.0034101882,
-0.0326466,
0.008899351,
0.004520092,
0.016283063,
-0.0083293095,
0.03240517,
-0.0079068085,
-0.043886475,
-0.010508879,
0.0002483452,
-0.0030279253,
-0.03642899,
-0.01950212,
-0.013573689,
0.0027345216,
0.026221901,
-0.005100193,
0.02068244,
0.0042719566,
-0.009201137,
-0.0036784431,
-0.030527389,
-0.009241376,
-0.032136917,
-0.011776383,
0.005572992,
0.007886689,
0.010951499,
-0.0150625035,
0.0017973067,
-0.004603922,
-0.025551263,
-0.002273459,
-0.017315842,
0.00449662,
0.001849281,
-0.01514298,
0.0036851494,
-0.0010067936,
0.005479103,
-0.02215784,
-0.023297925,
-0.033853747,
0.02940072,
0.012708568,
-0.007812919,
0.009918719,
0.017919416,
-0.0076251407,
-0.014096786,
-0.017369494,
-0.014579644,
0.021084823,
-0.008953001,
-0.036294866,
-0.019166801,
-0.0030296019,
-0.01543806,
-0.022533398,
0.038682334,
0.023364987,
-0.0035007242,
-0.02749611,
-0.054241106,
0.027603412,
0.02572563,
-0.007021568,
-0.0016246177,
-0.003021219,
0.02724127,
0.013949246,
0.009563281,
0.004969419,
-0.031010248,
0.005418746,
-0.0069276784,
0.004298782,
-0.012990235,
-0.0069947424,
0.014646709,
-0.011065508,
0.0132987285,
0.0067868447,
0.004107651,
-0.025323248,
0.006169859,
0.03259295,
-0.0069679166,
0.002424352,
0.0023153736,
0.007698911,
-0.01922045,
0.027657064,
0.002441118,
-0.030420087,
-0.015008853,
-0.005951902,
-0.012607972,
0.017999893,
-0.025215944,
0.035704706,
0.01124658,
0.019032674,
-0.029534847,
-0.0062402757,
0.037019152,
-0.00025735688,
-0.026141424,
-0.0070148613,
-0.007879983,
0.010730189,
0.0026406324,
-0.003225763,
0.017906003,
0.001212176,
0.013164601,
-0.031037074,
-0.009858361,
-0.00855062,
0.00035711413,
-0.007846451,
-0.044288855,
-0.0226407,
0.03288803,
0.013318848,
-0.006206744,
0.0013295375,
0.010274156,
-0.026074361,
-0.027174205,
-0.013365792,
0.026503569,
-0.0062905736,
-0.033558667,
-0.003202291,
-0.02121895,
0.02142014,
-0.002905534,
0.019515531,
0.0040674126,
0.014445517,
0.022318793,
0.0034738989,
-0.029776275,
-0.013828532,
-0.0046508666,
-0.00014167203,
-0.008912764,
-0.007021568,
0.013989485,
-0.00013842364,
-0.012165352,
0.02797897,
0.004882236,
0.0053282096,
0.00943586,
0.010066259,
-0.011293524,
0.016215999,
-0.005502575,
-0.012426901,
-0.008054349,
0.004107651,
0.023901496,
0.019435056,
0.026449917,
-0.021728633,
-0.011796502,
0.005495869,
-0.036777724,
-0.021192124,
-0.020467836,
0.034175653,
0.00247465,
0.013110951,
0.04289393,
0.009878481,
-0.00016975495,
-0.002223161,
0.0006756666,
0.0007473409,
-0.020159343,
-0.0045368583,
-0.0029206234,
0.02450507,
0.0034018054,
0.009730941,
0.02587317,
-0.015666077,
0.021178711,
-0.030420087,
0.04278663,
-0.008195182,
0.022077365,
-0.010093085,
-0.017047588,
0.00096907024,
0.0016011455,
-0.021554267,
-0.008342722,
0.010877729,
0.000029418952,
0.07709641,
0.011105746,
-0.029803101,
0.0030195424,
-0.0022198078,
0.01783894,
-0.007631847,
0.021500617,
-0.010052846,
-0.0025551263,
0.0076519665,
-0.00569706,
0.025618328,
-0.010676539,
-0.03814582,
0.023928322,
0.008872526,
-0.008175063,
-0.0071825203,
-0.021017758,
0.030259134,
-0.016108697,
-0.00104787,
0.0029910402,
-0.022238318,
-0.007537958,
0.028971512,
0.00142175,
-0.00847685,
-0.035892483,
0.0028652959,
-0.005274559,
0.003098342,
-0.0021963357,
0.007960459,
0.0015215073,
-0.000741892,
0.0074507752,
0.018737594,
0.0051236656,
-0.04219647,
0.04385965,
-0.018992435,
-0.054133806,
-0.028193573,
-0.023016255,
0.014874725,
0.006770079,
-0.01656473
] |
Patent ductus arteriosus (PDA) is a common diagnosis among extremely premature infants, especially in those with lung disease. Treatments are often used to close the PDA. Despite nearly three decades of research, the question of whether the benefits of treatments to prevent ductal patency or promote closure outweigh the risks of these treatments remains unanswered. The authors rarely use treatments designed to close the PDA. This article reviews three considerations in support of this restrained approach: rates of spontaneous closure of the ductus arteriosus; adverse effect of persistent ductal patency; and benefits and risks of treatments for closure.
|
[
-0.016234433,
0.011317529,
0.020332962,
-0.029248593,
-0.017072769,
0.01555578,
-0.019880528,
0.025788795,
-0.037685174,
0.0014945326,
-0.0032452233,
0.024710936,
0.0054757944,
0.020825317,
0.0024734223,
-0.0031886688,
0.035609297,
-0.0071125445,
-0.008755948,
-0.008423275,
-0.029461503,
-0.000097878576,
-0.030579284,
-0.008403315,
-0.010545728,
0.005798487,
0.04529673,
-0.024165353,
-0.012295587,
-0.009847115,
0.013772654,
0.0075383657,
-0.009541056,
-0.0038922718,
0.0065636346,
0.0011751667,
-0.0014862157,
-0.011969567,
0.025682341,
-0.0110181235,
0.010978202,
0.0037891432,
-0.0042382516,
-0.013240377,
-0.015635623,
-0.008928938,
0.0048403894,
-0.018323619,
-0.011942954,
-0.0020376209,
0.01646065,
-0.0032568667,
-0.004637459,
0.010978202,
0.0035995198,
-0.0030223324,
-0.010638876,
0.022222543,
-0.0032751637,
-0.025549272,
-0.019441398,
0.007152465,
-0.024537945,
0.015968295,
-0.0329213,
0.01590176,
0.010825173,
0.03486411,
0.025496043,
0.03470443,
0.046201598,
0.022342306,
0.027864674,
-0.006067952,
0.0018529876,
0.0029258572,
-0.013253684,
-0.008862403,
-0.019428091,
0.010805213,
0.0004869498,
-0.02935505,
-0.0065736147,
0.036487553,
0.023965748,
-0.014770673,
-0.0009439591,
0.010326164,
-0.021570506,
-0.010279589,
0.0075649796,
0.014690831,
0.003815757,
0.01043262,
0.016354196,
0.005372666,
0.032442253,
0.023686303,
0.017445361,
-0.02874293,
-0.004670726,
0.00615112,
-0.00080589985,
-0.016540492,
0.0020026902,
-0.005153102,
0.0036228069,
-0.009920303,
0.0057286257,
-0.011064697,
-0.014131941,
0.05442527,
-0.0060014175,
-0.0066767433,
0.04745245,
-0.009228343,
0.014384772,
0.02262175,
-0.0032152827,
0.0068330993,
0.034810882,
0.012042755,
0.021610426,
-0.023167334,
0.006201021,
0.0005867517,
-0.041437723,
-0.005835081,
-0.003486411,
-0.012521804,
-0.012774636,
0.032069657,
0.032176115,
-0.0023919174,
-0.014491227,
0.0009439591,
-0.027571922,
-0.003928866,
-0.023925828,
-0.03374633,
0.014145248,
0.002188987,
-0.014371465,
-0.016780017,
-0.013533129,
0.03249548,
0.022688285,
0.008157137,
0.007372029,
-0.0048104487,
0.0016567105,
-0.023553235,
-0.022302385,
-0.011962914,
0.0054957545,
0.010652184,
0.009294878,
0.024511332,
-0.009926956,
0.0016009879,
0.0019494627,
0.0032235994,
-0.0008462364,
-0.0030289858,
0.007817811,
0.015396098,
-0.012348815,
0.00850977,
0.002225581,
-0.018243777,
-0.016048135,
0.006360704,
-0.03709967,
-0.0011618597,
0.009321492,
0.009208383,
-0.02361977,
0.011610281,
-0.017511897,
-0.030978492,
-0.0070859306,
-0.01956116,
0.0031404314,
0.046387896,
-0.017525204,
-0.0032701737,
0.020359576,
-0.0058683483,
-0.0018646311,
-0.016154591,
-0.0040220143,
0.012095983,
-0.014477921,
-0.008789215,
-0.63745433,
-0.0035529456,
-0.002759521,
-0.021996327,
-0.003107164,
0.0281042,
0.006107873,
-0.013865802,
0.0054358738,
0.02150397,
-0.0020891852,
0.0025615806,
-0.0025066896,
0.014371465,
-0.0040319944,
-0.011816538,
0.007219,
-0.020319656,
0.021357594,
-0.015436018,
0.0022971057,
0.0246444,
0.0056820516,
-0.016780017,
0.012155864,
0.02012005,
0.039707825,
0.008549691,
0.0005871675,
0.0010429292,
-0.016646948,
0.0031554014,
-0.0014645921,
0.01461099,
0.056634218,
0.004783835,
-0.0072589205,
0.028503407,
-0.005931556,
0.042422436,
0.006300823,
0.019268408,
0.03313421,
0.012348815,
-0.00816379,
0.017964331,
0.034571357,
-0.017990945,
0.0055390024,
-0.01715261,
0.0035429653,
-0.009614244,
-0.0073321084,
0.0011710082,
0.0044378554,
-0.005455834,
0.034624584,
-0.026973112,
0.022528602,
-0.0016117997,
0.021583812,
0.0110181235,
0.023566542,
-0.011157846,
-0.0040319944,
0.016088057,
0.0014562752,
0.0075915935,
-0.004171717,
0.0022239177,
-0.011823191,
0.033852786,
0.010984856,
0.001951126,
0.033453576,
0.0051930225,
0.007857732,
0.028450178,
-0.00976062,
0.020545872,
0.002678016,
0.0037425691,
-0.012368775,
0.0094745215,
0.04258212,
0.016181204,
-0.008137177,
0.010079986,
-0.016500572,
-0.0026464122,
-0.0113308355,
0.005808467,
-0.013639585,
-0.01956116,
-0.0107985595,
0.020838624,
-0.008130523,
-0.02090516,
-0.0031371044,
0.022475375,
-0.014903742,
0.009062007,
-0.025589192,
-0.01934825,
0.032868072,
0.02408551,
-0.0060746055,
-0.010991509,
0.021171298,
-0.042688575,
-0.012155864,
-0.009421294,
0.017897798,
-0.014118634,
0.031271245,
-0.013732733,
-0.0074651777,
-0.025908558,
-0.0048603495,
-0.019627696,
0.02004021,
-0.011131232,
-0.009700739,
-0.017738113,
-0.010805213,
-0.007352069,
-0.005479121,
-0.010552381,
0.00453433,
-0.00850977,
0.013020813,
0.0069794753,
-0.00034556387,
-0.010485847,
0.009707392,
0.011756657,
0.010984856,
0.007671435,
-0.026467448,
-0.005971477,
-0.008676107,
0.014065406,
0.0012441963,
0.0066833966,
-0.014823901,
-0.020585794,
0.0058217742,
-0.005675398,
-0.02421858,
0.020678941,
-0.03515686,
-0.0329213,
0.007631514,
0.014890435,
-0.0028044318,
-0.012395388,
0.022515295,
-0.023167334,
-0.016899778,
-0.020186586,
0.004404588,
0.024511332,
-0.026414221,
-0.013366793,
-0.012388735,
-0.008356741,
0.0014279981,
-0.004271519,
-0.021756802,
-0.02727917,
-0.00487033,
-0.019281715,
-0.0002474254,
-0.0066035553,
0.016300967,
-0.009913649,
-0.0081704445,
-0.035289932,
-0.027571922,
0.0064305654,
-0.018656291,
-0.018044174,
0.0065835947,
0.0016467304,
0.038377136,
0.0018945716,
0.013333526,
0.006214328,
-0.008516423,
0.024484718,
0.0021424128,
0.021397514,
-0.021583812,
0.03270839,
-0.0042482316,
-0.011616934,
-0.0027445506,
0.016646948,
-0.004271519,
0.04572255,
-0.00032789062,
-0.0075383657,
0.03829729,
-0.019201875,
0.002238888,
-0.02860986,
0.004308113,
-0.012661527,
0.017964331,
-0.013107308,
-0.013486556,
0.010133213,
0.016633641,
-0.01892243,
-0.010233016,
0.050353356,
-0.0031470847,
-0.018483302,
-0.009913649,
0.016686868,
0.00523627,
-0.021996327,
0.015795305,
0.0050100526,
0.0024235214,
-0.012974239,
0.032522094,
0.019813992,
-0.011104618,
-0.046308056,
-0.0114971725,
0.01628766,
0.001571879,
0.013785961,
-0.014983583,
0.037392423,
0.009441254,
-0.02283466,
0.025695648,
0.006570288,
-0.008636186,
-0.0065636346,
0.03348019,
0.0082236715,
0.000201371,
0.0029724315,
0.02930182,
0.017378828,
-0.02908891,
-0.017285679,
0.012468576,
-0.0025199966,
-0.011237687,
-0.004634132,
-0.0025482737,
-0.024072204,
0.013167189,
0.009507788,
0.020838624,
0.016088057,
0.031218017,
-0.0061744074,
-0.0033100944,
-0.021104762,
0.029727641,
-0.009348106,
0.00451437,
-0.006181061,
0.009288224,
-0.022954423,
-0.004970132,
0.0051697353,
0.021477357,
-0.034970567,
0.019680923,
0.020825317,
-0.024458105,
0.016740095,
0.017445361,
0.005888309,
0.013679505,
-0.01823047,
0.017831262,
0.029009068,
-0.014677525,
-0.00939468,
0.027997743,
0.02017328,
-0.032069657,
0.015436018,
-0.012561725,
0.0026197983,
0.0051664086,
0.015263028,
-0.0018696211,
-0.028290495,
0.025070222,
0.011736697,
0.013280299,
-0.010938282,
-0.012887744,
0.0027628476,
-0.014783979,
-0.011004817,
0.019720843,
0.0061943675,
0.0012466913,
-0.026334379,
0.01262826,
-0.0025698973,
-0.019201875,
-0.029807484,
-0.013932337,
0.005529022,
-0.005269537,
-0.011304222,
0.01620782,
0.004444509,
0.018483302,
0.0064305654,
-0.0116435485,
0.0114971725,
-0.0041950042,
-0.00976062,
0.051045313,
-0.0077645835,
0.018469995,
0.027172714,
-0.012708101,
-0.0075317123,
-0.00939468,
-0.031697065,
0.031830136,
0.008829136,
0.007298841,
-0.0090886215,
0.003902252,
0.011503826,
0.019774072,
0.021597119,
0.005578923,
-0.026400914,
-0.023553235,
-0.004753894,
-0.01068545,
-0.011863112,
0.026560597,
0.021450743,
0.013586357,
-0.0051065274,
0.03856343,
0.019108726,
0.019774072,
0.002330373,
-0.012115943,
0.015076731,
0.001914532,
0.020891853,
-0.0055090617,
-0.009175116,
0.025669033,
-0.009521096,
0.0048636766,
0.0494751,
0.023140721,
0.03430522,
-0.0032635203,
-0.00906866,
0.007451871,
-0.0188692,
0.008516423,
-0.0034015793,
0.0149702765,
-0.02693319,
0.02741224,
-0.014118634,
-0.014584376,
-0.0073587224,
0.061477933,
0.0027112833,
0.014251703,
-0.0006491278,
0.006743278,
-0.005725299,
-0.0029325108,
-0.018469995,
0.008476503,
0.009986837,
0.01262826,
-0.01827039,
-0.015462632,
-0.001553582,
-0.019441398,
-0.024897233,
-0.011710083,
-0.0025549273,
-0.026866656,
-0.0046141716,
0.004328073,
0.0011502162,
0.026427528,
-0.005981457,
0.014158554,
0.019494627,
0.017964331,
-0.0048370627,
-0.002395244,
-0.0088490965,
0.014411386,
-0.00031084116,
-0.012348815,
-0.008895671,
-0.03313421,
0.019867219,
0.02042611,
-0.0009239987,
0.015316256,
-0.01228228,
-0.0022954424,
0.034544744,
0.027545309,
0.016447343,
-0.017445361,
-0.021064842,
-0.0006470486,
0.0031687084,
-0.01564893,
-0.0008458206,
0.008955552,
-0.012382082,
-0.008270246,
-0.008090602,
-0.016101364,
-0.021796722,
0.023140721,
0.0014529484,
0.007831118,
-0.028689703,
0.017219145,
0.032628547,
-0.018483302,
0.031909976,
0.013459941,
-0.01913534,
-0.018975656,
0.010119907,
0.030765582,
0.021597119,
-0.015422711,
0.011463905,
-0.0007181574,
-0.022315692,
-0.049448486,
0.0006973654,
0.001679166,
0.0128744375,
0.018802667,
-0.026746893,
-0.033160824,
-0.01840346,
-0.00015354929,
-0.008270246,
-0.028450178,
-0.013732733,
0.0038822917,
0.014491227,
-0.0008408305,
-0.012169171,
0.044977363,
-0.024338342,
-0.0042648655,
0.014171861,
-0.028822772,
0.00234867,
-0.014491227,
-0.0032701737,
-0.0052562305,
0.010213055,
-0.012555072,
-0.05658099,
0.019867219,
-0.033985853,
0.014943662,
0.008622879,
0.005934883,
-0.024484718,
0.02038619,
0.037152898,
0.0053028045,
0.004843716,
-0.007744623,
0.0023636403,
-0.0038490244,
0.029275207,
0.0031337778,
0.0054026064,
0.039761055,
-0.0011959587,
0.037791632,
0.009720699,
-0.02288789,
-0.016354196,
0.009833808,
-0.010179788,
-0.011064697,
0.0005788507,
0.0051930225,
-0.012555072,
-0.051364683,
-0.0066102087,
0.0070859306,
0.00061294966,
-0.0009664145,
-0.0155957015,
0.02327379,
-0.014025485,
0.037339196,
0.020279733,
0.014438,
0.017964331,
-0.022555215,
-0.014624297,
0.0056487843,
0.0019444725,
-0.015103346,
0.01965431,
0.004407915,
-0.020332962,
-0.028210653,
-0.010858441,
-0.010332817,
-0.022475375,
-0.0015843542,
-0.020053517,
-0.021597119,
-0.012940972,
-0.013100655,
-0.042901486,
0.02331371,
0.003915559,
-0.00048445477,
0.02805097,
-0.025881944,
0.009035394,
-0.021118069,
-0.025669033,
-0.004574251,
-0.0011360777,
0.029488117,
0.019321637,
-0.020519258,
-0.008935591,
-0.03284146,
0.009461215,
0.0027129466,
0.01465091,
0.0020825318,
0.005489101,
-0.0072456137,
-0.0065370207,
0.042821642,
-0.018629678,
-0.019800685,
0.016314274,
-0.0020392842,
-0.013240377,
-0.00030813817,
-0.03720613,
0.0068663666,
0.004634132,
-0.011557053,
0.0014704138,
-0.006310803,
-0.035396386,
0.0076381676,
0.00009709888,
-0.0140521,
0.03571575,
0.010366085,
-0.0093281455,
-0.009015433,
-0.016660254,
-0.0020975021,
0.00089987996,
0.010598956,
0.008622879,
0.0267602,
0.018549835,
0.008449889,
-0.005505735,
-0.004624152,
-0.0051697353,
-0.035582684,
0.032468867,
0.009966877,
-0.018696211,
0.018336926,
-0.0053759925,
-0.0031005105,
-0.028343722,
-0.00506328,
-0.02922198,
-0.02077209,
-0.009055354,
0.007970841,
0.015289642,
-0.016447343,
-0.005505735,
-0.003928866,
-0.012215746,
-0.01534287,
-0.027704991,
0.028130813,
-0.020958386,
-0.052908283,
-0.0046208254,
-0.029807484,
-0.0010620579,
-0.0024152047,
-0.012748022,
0.0004441182,
0.010771945,
-0.0143448515,
0.042289365,
-0.010791906,
0.008250286,
0.00045285086,
0.01861637,
-0.020053517,
-0.0041783703,
0.0042748456,
0.0073321084,
0.0028127485,
-0.011310875,
0.0056587644,
0.0069395546,
-0.008529731,
0.0060978923,
-0.0014487901,
0.005525695,
0.00005379943,
-0.0028110852,
-0.016567105,
0.015329563,
-0.010918321,
-0.021144683,
0.027545309,
-0.032043044,
-0.027026339,
0.0065835947,
0.019401478,
0.015529167,
-0.017738113,
0.0036860146,
-0.03978767,
0.006360704,
-0.039415073,
-0.017139303,
-0.006227635,
0.0010304541,
-0.023979057,
0.013905724,
0.008669454,
-0.017857876,
-0.0018662944,
0.018656291,
-0.026108162,
0.0018197203,
-0.037339196,
0.020891853,
0.017445361,
-0.014624297,
-0.008303513,
-0.00079841475,
-0.011883073,
0.033799555,
0.043699898,
-0.017179223,
-0.0234867,
0.020159973,
-0.04689356,
0.0116435485,
-0.0134998625,
0.006560308,
0.0013057408,
0.002599838,
0.02154389,
0.012169171,
0.008017414,
0.011264301,
-0.008010761,
-0.021384208,
0.020625714,
-0.007731316,
0.046441123,
-0.0081504835,
-0.03912232,
-0.019241795,
0.0141984755,
0.01646065,
0.015622315,
0.0036693811,
-0.0114040235,
0.01555578,
0.0060945656,
0.016593719,
0.010020105,
0.0045775776,
0.011443945,
-0.021184605,
-0.015316256,
0.026267845,
-0.005994764,
-0.006290843,
-0.01753851,
-0.01137741,
0.014424693,
0.0019378191,
0.001642572,
0.00042540533,
0.007984147,
-0.0032186094,
-0.0041650636,
0.0006287516,
-0.035130247,
0.026480755,
0.015941681,
-0.012940972,
-0.00071150396,
-0.0022372247,
-0.005598883,
-0.015542474,
0.008250286,
-0.014690831,
-0.010951589,
-0.002618135,
0.0061744074,
-0.00758494,
-0.00850977,
-0.008549691,
-0.007704702,
-0.019295022,
0.031643838,
-0.01611467,
0.017272372,
-0.0066767433,
0.011616934,
-0.014211782,
0.008250286,
-0.008383355,
0.012674834,
-0.026959805,
0.00074061286,
-0.01499689,
-0.03606173,
0.01701954,
0.003240233,
-0.010712064,
0.004354687,
-0.0034098963,
0.19066143,
0.0023137394,
-0.02762515,
0.0076381676,
-0.021384208,
-0.0074052964,
0.018988963,
0.005079914,
-0.019960368,
0.01749859,
0.007824465,
-0.011949607,
-0.016167898,
0.0049002706,
0.024657708,
-0.01555578,
-0.023965748,
-0.0139589505,
-0.018376846,
-0.009640858,
-0.009002126,
-0.015409404,
0.027438853,
0.008263593,
0.011084658,
-0.001137741,
0.012621606,
0.004451162,
0.024298422,
0.007298841,
-0.0153561765,
0.00651706,
0.012222399,
0.015808612,
-0.007192386,
-0.022382226,
0.0023686304,
-0.01900227,
0.01516988,
-0.019680923,
-0.0047505675,
0.022355612,
-0.0123421615,
0.008449889,
-0.026307765,
0.041836932,
0.0041950042,
-0.025828717,
0.008403315,
-0.021597119,
-0.01892243,
0.02943489,
0.021490663,
0.010113253,
-0.042289365,
-0.015462632,
0.0050333394,
0.02662713,
-0.012335507,
0.010073332,
0.011503826,
0.0048969435,
-0.017644966,
0.034012467,
-0.020878546,
0.014025485,
-0.0066468026,
0.01711269,
-0.0029208672,
-0.01892243,
0.01135745,
-0.021770108,
-0.015036811,
0.0040785684,
-0.012076023,
-0.025669033,
0.017072769,
0.029594572,
-0.0064971,
0.01210929,
0.009680779,
-0.017658273,
-0.020665634,
-0.01688647,
-0.013932337,
-0.03646094,
-0.01576869,
0.025096836,
-0.010658837,
-0.027651763,
0.0021374228,
-0.01243531,
-0.02922198,
0.003130451,
0.021690266,
-0.0069062873,
0.0040186876,
0.02202294,
0.0073121483,
0.03813761,
-0.011630241,
0.062808625,
0.027545309,
0.0005867517,
0.00088241464,
0.0123421615,
-0.02874293,
0.05594226,
0.001951126,
-0.009574323,
0.011696775,
0.0015302949,
-0.015954988,
-0.038190838,
0.00097057293,
0.02935505,
0.018935736,
-0.019707536,
-0.0026480756,
0.0049867653,
0.012654874,
-0.020013595,
-0.0015236414,
0.023473393,
-0.003198649,
-0.017125996,
-0.009108582,
0.012155864,
-0.014491227,
-0.02585533,
-0.023087492,
-0.014451306,
-0.0087759085,
-0.0008641176,
-0.005642131,
0.027891288,
0.0104925,
-0.009640858,
0.009121888,
0.04654758,
0.0036194802,
0.0032917974,
0.02421858,
0.040612698,
0.010026759,
-0.037392423,
0.010964896,
-0.023566542,
-0.013852496,
-0.005362686,
0.0021390861,
-0.0011710082,
0.026467448,
-0.0075317123,
0.0028094219,
-0.029834097,
-0.006127833,
-0.024724243,
0.010372738,
-0.0011003152,
-0.010625569,
-0.00020750467,
0.019095419,
0.0011335826,
-0.0072722277,
-0.009281571,
-0.16660254,
0.008875711,
-0.0004632469,
0.016553799,
0.024671014,
0.0067831986,
0.030765582,
0.010831826,
-0.018949043,
-0.004377974,
0.020918466,
0.017791342,
0.008789215,
0.0055955565,
0.0028842732,
0.0065470007,
-0.0067665647,
0.025802102,
0.010040065,
-0.02206286,
0.018815974,
-0.023979057,
0.01680663,
-0.024857312,
0.00523627,
-0.0006761575,
-0.0043946076,
0.006117853,
-0.008882364,
-0.016780017,
-0.021517277,
0.00045077165,
0.03654078,
0.0019660962,
0.010811866,
-0.014225089,
0.013513169,
-0.021743495,
-0.012209092,
0.041916773,
-0.0066767433,
0.027891288,
0.017259065,
-0.008596266,
-0.010239669,
0.0069195945,
-0.019933755,
-0.011969567,
0.026001707,
-0.027252557,
0.01336014,
-0.01642073,
-0.00906866,
0.005998091,
-0.026054934,
0.0034165496,
-0.007731316,
0.035289932,
-0.018842587,
-0.019468013,
0.003486411,
-0.0011177806,
0.016992927,
0.025602499,
0.008596266,
-0.034331832,
-0.000042285832,
0.005552309,
-0.034145538,
0.014131941,
-0.012076023,
-0.022089474,
-0.0017931064,
-0.02029304,
0.011004817,
0.012355468,
-0.023939135,
0.019334944,
0.0013747704,
0.015289642,
-0.018909123,
0.006234288,
-0.015369483,
-0.016300967,
-0.022355612,
0.028902613,
0.01230224,
0.0016716808,
-0.00083126617,
0.004427875,
0.023766145,
-0.033373736,
-0.0028443525,
-0.017072769,
-0.00093231554,
0.022116087,
-0.0034564703,
-0.017990945,
-0.0064638327,
-0.027571922,
-0.0019112052,
-0.030792195,
-0.004933538,
-0.008755948,
0.030978492,
0.009587631,
-0.007292188,
0.0055223685,
0.039441686,
-0.011636895,
0.0036727078,
0.002691323,
0.0013232061,
0.011577014,
-0.008037375,
0.016553799,
0.008303513,
0.0020193239,
0.0031770254,
-0.026520675,
0.033985853,
0.0040652617,
0.0053527053,
0.016686868,
0.013087348,
-0.0074385637,
-0.13796607,
-0.0093281455,
0.042475663,
0.0033699756,
-0.01823047,
-0.01210929,
-0.008988819,
0.017405441,
-0.015449325,
0.014398079,
-0.011836498,
-0.02672028,
0.00956767,
0.00016384135,
0.037552107,
-0.047665358,
0.004670726,
-0.019068806,
-0.025110144,
0.023845987,
-0.0064937733,
0.008662799,
0.030073622,
-0.024152046,
-0.013506516,
-0.029913938,
-0.01823047,
0.014757366,
0.0019045518,
-0.010346124,
0.01763166,
0.00810391,
0.008642839,
-0.0088490965,
-0.015316256,
-0.021650346,
-0.005678725,
-0.030313145,
0.05003399,
-0.025096836,
0.0076847416,
0.0031504114,
0.045349956,
-0.0094013335,
0.007804504,
-0.030472828,
-0.04431202,
0.006004744,
0.007844425,
-0.013253684,
-0.004747241,
-0.02658721,
-0.0026015013,
0.007831118,
0.018030865,
-0.038669888,
0.009867076,
-0.011610281,
0.005379319,
-0.014038793,
0.0114040235,
-0.0007564148,
-0.011596974,
0.008383355,
0.011310875,
-0.03896264,
-0.01564893,
-0.0086295325,
0.0028393625,
-0.020918466,
-0.026573904,
-0.01646065,
0.0031271244,
-0.006410605,
-0.026919883,
-0.00072980096,
-0.013113962,
-0.009680779,
-0.0038323908,
-0.015954988,
-0.00669005,
-0.008203711,
0.011962914,
-0.019667616,
0.026414221,
0.0148771275,
-0.004680706,
-0.021583812,
-0.0011710082,
-0.019122032,
-0.015954988,
0.010771945,
-0.0029358375,
-0.008549691,
-0.030073622,
0.03249548,
-0.0041883504,
-0.010745332,
0.013839189,
0.0153561765,
-0.016221127,
-0.0055822497,
-0.04008042,
-0.0038190838,
0.017964331,
0.00615112,
-0.0065303673,
-0.0049401913,
0.016088057,
0.014185169,
0.033799555,
-0.019161953,
-0.039548144,
0.016088057,
-0.014664217,
-0.009674125,
-0.004637459,
0.0027179369,
0.019680923,
0.009966877,
0.0009930283,
-0.0012234042,
0.014744058,
0.0038789648,
0.00452435,
0.009454561,
0.0023004324,
0.000021571752,
-0.00018369776,
0.016553799,
0.0023270464,
0.00031687084,
-0.0032053024,
-0.044791065,
0.024591174,
-0.002024314,
-0.02038619,
0.015196494,
-0.013333526,
0.012847824,
0.018163934,
0.026986418,
-0.010379392,
-0.033852786,
0.025070222,
-0.01534287,
0.011483865,
0.0020575812,
-0.023633076,
0.019175261,
0.01336014,
-0.013240377,
0.016048135,
0.0148771275,
-0.021517277,
-0.028157426,
-0.02930182,
0.0002900491,
0.010692104,
-0.008303513,
-0.0062110014,
-0.022262463,
0.060306925,
-0.0029707681,
-0.010911668,
0.0023386898,
0.018988963,
-0.0011443944,
-0.015954988,
-0.0034165496,
0.0009422957,
-0.005099874,
-0.009108582,
-0.020492645,
-0.013393407,
0.0027761545,
0.031430926,
-0.02004021,
-0.00086162257,
0.0087759085,
-0.007937573,
0.020572485,
0.011696775,
-0.015010197,
-0.026746893,
0.00006887367,
0.03534316,
-0.016700175,
-0.0070393565,
0.0016184532,
0.0021091455,
0.018603064,
-0.036168188,
0.0108717475,
-0.018177243,
0.041011903,
-0.0128744375,
0.017338907,
0.014823901,
-0.012721408,
-0.009308185,
0.012861131,
-0.0031204708,
0.013213764,
-0.002485066,
0.013000853,
-0.028796159,
-0.0068397527,
0.00702605,
-0.04974124,
-0.019361557,
0.00019679675,
0.0037159552,
0.0140521,
-0.013140576,
0.010931629,
-0.007006089,
-0.00027299963,
-0.0065669613,
-0.02150397,
-0.010292897,
0.004045301,
-0.007890999,
0.03324067,
-0.0046041915,
0.004833736,
-0.0017997599,
-0.0042216177,
0.025695648,
-0.027332397,
0.04503059,
0.015795305,
-0.0018080767,
0.0006977812,
-0.012348815,
-0.024205273,
0.022475375,
0.0066833966,
0.02421858,
0.011663509,
0.0012832853,
0.055569664,
0.018243777,
-0.03209627,
-0.00054807845,
0.0032069657,
0.014624297,
0.0074851383,
0.00072855345,
0.01043262,
-0.018975656,
0.025788795,
-0.010692104,
0.020479338,
0.0019860566,
-0.013047427,
0.023500007,
0.0020908485,
-0.0065137334,
-0.0048270826,
-0.000018582896,
0.0029624514,
-0.009660819,
0.012275627,
-0.0014304931,
-0.038110998,
-0.017990945,
0.0143448515,
0.0078111575,
0.013353487,
-0.017764729,
0.0055755964,
0.011171153,
-0.03986751,
-0.020678941,
0.0045210235,
0.002476749,
-0.03611496,
-0.0054125865,
0.0039920737,
0.020053517,
0.005016706,
0.03361326,
-0.011670162,
-0.012189131,
-0.014664217,
-0.0033932626,
0.00004155811,
-0.0069195945,
-0.025229905
] |
In recent years, the treatment of autoimmune diseases has been significantly advanced by the use of biological agents. However, some biologics are accompanied with severe side effects, including tuberculosis and other types of infection. There is thus a critical need for nonsystemic and lesion-specific methods of delivering these therapeutic agents. We attempted to treat a mouse model of arthritis by using T cells that expressed a regulatory molecule and were specifically directed to the inflamed paw. To this end, we first identified the TCR alphabeta genes accumulating in the inflamed paw of mice with collagen-induced arthritis (CIA) by a combination of single-strand chain polym
|
[
-0.024890825,
0.008403545,
0.009015949,
-0.020603996,
-0.003817319,
0.022590907,
-0.029259307,
-0.0035655529,
-0.02162467,
-0.0064200363,
0.007314827,
-0.0012316128,
0.018902874,
0.007416894,
0.009322152,
0.017038444,
0.041425735,
0.024931652,
-0.0010912701,
-0.007301218,
-0.009424219,
0.021148356,
0.0036948381,
-0.008648507,
-0.019188663,
0.00295485,
0.014030859,
-0.05432705,
-0.013751875,
-0.0005953929,
0.003402245,
-0.0031623868,
-0.01775972,
-0.0021757358,
-0.0023781692,
-0.018862046,
0.020331817,
-0.00974403,
0.011846618,
0.012690375,
0.0201549,
0.008621289,
0.009043167,
-0.0031742947,
0.007859186,
-0.0075461795,
-0.007539375,
-0.009104408,
-0.024387293,
-0.00774351,
0.028007282,
0.004885624,
-0.026673602,
-0.007634638,
-0.01880761,
-0.016262732,
0.0059097,
0.021611061,
0.008281064,
-0.039384387,
-0.0122616915,
0.009573918,
-0.029585924,
-0.0046950984,
-0.011064101,
0.0068521216,
-0.0019477853,
0.0045317905,
-0.0013481396,
-0.014234994,
0.026455859,
0.02176076,
-0.0018712349,
-0.005481017,
0.018603476,
-0.0077094873,
-0.021692716,
-0.002886805,
-0.0019596932,
0.01148598,
0.016466867,
-0.004276622,
0.012431803,
0.019324752,
0.022182638,
0.0038003079,
0.008873055,
0.015446193,
-0.027612621,
-0.003929593,
0.012254887,
0.016902354,
-0.013302778,
0.008131366,
-0.023666017,
0.03285208,
0.02401985,
0.03644485,
-0.013976423,
-0.037234172,
0.012098383,
0.01021354,
-0.009308543,
-0.03391358,
-0.036553722,
0.014030859,
-0.0028953105,
-0.0045181816,
0.017433103,
-0.019528886,
-0.025693756,
0.046787675,
-0.0005316008,
-0.032117195,
0.026877737,
0.008144975,
0.020508733,
-0.015936116,
0.019569714,
-0.002635039,
0.017596412,
0.009655572,
0.012690375,
-0.005498028,
0.024918044,
-0.011690115,
-0.037343044,
0.0036335979,
-0.017487539,
0.0057531963,
-0.00760742,
0.032743208,
-0.0014757238,
0.012288909,
-0.0052394574,
0.0050421273,
-0.02201933,
-0.008267456,
-0.016031379,
-0.030946821,
-0.018331297,
0.04254167,
-0.0076414426,
0.005385754,
0.015174014,
0.021107528,
0.026605556,
0.015323712,
-0.0050863563,
0.020304598,
-0.011295454,
-0.022386773,
0.003967018,
-0.025339922,
-0.011785377,
-0.00010270527,
-0.013030599,
0.027068263,
-0.002526167,
-0.013949205,
0.011458761,
-0.006287349,
0.0095467,
-0.0018099943,
0.014997097,
0.019596932,
0.0014221384,
0.008961514,
-0.008893468,
-0.013323192,
0.0023254345,
0.023693236,
0.015541456,
0.018236034,
-0.0058892863,
0.0047019026,
-0.029966975,
-0.00410651,
-0.02747653,
-0.023135267,
-0.008628094,
0.016861526,
0.033423655,
0.0028680926,
-0.006134248,
-0.00480397,
0.0058484594,
-0.008893468,
-0.00006474898,
-0.014194166,
0.0054197763,
-0.0021995516,
0.010002601,
-0.039711006,
-0.6414729,
-0.030130282,
0.040255364,
-0.004429723,
0.002720095,
0.03698921,
0.015976943,
-0.0224276,
-0.02671443,
0.029477052,
-0.011036883,
0.015623109,
0.014901834,
-0.019297535,
-0.016480476,
-0.03165449,
-0.0020634616,
-0.018317688,
0.0101386905,
0.013248342,
0.012227668,
0.011921467,
0.006549322,
-0.003305281,
0.012459022,
-0.0048379926,
0.006896351,
-0.002624832,
-0.005127183,
0.0389489,
-0.019175053,
0.025203831,
-0.0055014305,
-0.014166948,
0.05405487,
0.013459282,
-0.022495644,
0.02548962,
0.019052573,
0.04044589,
-0.029694796,
-0.008396741,
0.025843455,
-0.007083474,
-0.017038444,
0.034267414,
0.005079552,
0.0067398474,
0.0076958784,
0.008560048,
0.009771248,
0.03042968,
-0.022060158,
-0.007457721,
0.026510295,
0.00087267585,
0.0070018205,
-0.011247822,
0.03777853,
-0.006763663,
0.0033767282,
0.016439648,
-0.006814697,
-0.029286526,
-0.034267414,
0.011043687,
-0.01721536,
0.0068317084,
0.021747151,
0.0070086247,
0.019637758,
0.011982707,
-0.015922507,
-0.008022494,
-0.0002626108,
0.02176076,
-0.0079272315,
-0.019583322,
-0.025108568,
0.002150219,
-0.0048686126,
-0.0089274915,
-0.0037016426,
-0.0053789495,
0.03696199,
0.0025601895,
-0.022005722,
0.033723053,
0.010165908,
0.0155958915,
0.021025876,
0.019583322,
-0.020508733,
-0.02282226,
-0.010662636,
0.010029819,
0.017773328,
-0.0051816194,
0.0043786895,
0.006161466,
-0.009825684,
-0.003150479,
0.015282885,
-0.009226888,
0.008716552,
0.01107771,
-0.04654271,
-0.0027098882,
0.034104105,
-0.034212977,
-0.0002373066,
-0.016480476,
0.0035961731,
0.00011652689,
0.02871495,
-0.016915962,
-0.017460322,
-0.0085940715,
-0.0034941058,
-0.019447234,
0.02871495,
-0.0059097,
-0.0010546959,
0.001033432,
-0.000659185,
0.0048516016,
-0.006117237,
-0.034376286,
-0.0010113174,
-0.01241139,
0.0018031899,
-0.012935336,
0.017596412,
-0.021161964,
0.024251204,
-0.0068895463,
0.017011225,
0.009369783,
0.012799246,
-0.017052053,
-0.028606078,
-0.016453257,
0.012445413,
0.013711047,
0.0056443247,
-0.00053457776,
-0.016875135,
0.013255147,
0.0036608158,
0.009383392,
0.0036404023,
0.0020923808,
0.019991592,
0.0066888137,
0.031736143,
-0.0055218437,
-0.00887986,
-0.033723053,
0.00017744834,
-0.016847918,
-0.008859446,
0.016058598,
0.018780394,
0.005981147,
-0.031246219,
-0.013731461,
0.016698219,
0.023407446,
-0.02338023,
-0.039030556,
0.01628995,
-0.019828284,
-0.012424999,
0.019869111,
0.017678065,
-0.002305021,
-0.013091839,
-0.01507875,
-0.015636718,
-0.0031164566,
-0.029340962,
-0.012778833,
0.019610541,
-0.0008080332,
0.016303558,
0.007845577,
0.021556625,
0.007968058,
-0.014847398,
0.033532526,
0.0011873835,
0.014289429,
-0.031545617,
0.022277901,
-0.003555346,
-0.020222945,
0.009158844,
0.00988012,
0.02042708,
0.017052053,
0.005011507,
-0.02602037,
0.030729078,
-0.027843975,
0.009669181,
-0.04003762,
-0.014643263,
-0.028197808,
0.040826943,
0.0002789841,
0.016058598,
0.0101999305,
-0.0018202012,
-0.0037118495,
0.015269276,
0.015623109,
-0.00033086832,
-0.009934556,
0.0024206974,
-0.018889265,
-0.016099423,
0.0125338705,
0.008757379,
-0.018086335,
-0.008485199,
0.015446193,
0.022400381,
0.009798466,
0.0031011463,
-0.008015689,
0.00071957486,
-0.0021127942,
0.013227929,
0.014561609,
0.012554284,
-0.0040588784,
0.005814437,
-0.0010257768,
0.037451915,
0.0076414426,
0.0045215837,
0.0049638757,
-0.005746392,
-0.0049196463,
0.004950267,
0.019692194,
0.020672042,
-0.004385494,
-0.018794002,
0.002233574,
-0.02135249,
-0.0080769295,
-0.024223985,
0.0014025755,
-0.005246262,
-0.022890305,
0.008240238,
0.017228968,
0.05008105,
0.03326035,
0.03282486,
0.00053202605,
0.017024834,
-0.027816756,
0.013119057,
0.016113034,
-0.0077094873,
-0.022999177,
-0.007920426,
0.01895731,
-0.03603658,
-0.0050319205,
0.027272396,
-0.020331817,
0.021937676,
0.019392798,
0.011431543,
0.018521823,
0.019801067,
0.00016256352,
-0.008281064,
-0.028361116,
0.019664977,
0.00026537513,
0.012948945,
-0.012996577,
-0.019855503,
-0.008811815,
-0.019202271,
0.013615785,
0.011132146,
0.010996056,
0.023788497,
0.006886144,
0.010873576,
0.0040384647,
0.053319987,
-0.004290231,
0.014316647,
-0.014548,
-0.0134865,
-0.016766263,
0.017433103,
-0.01735145,
0.03004863,
0.006872535,
-0.0062124995,
-0.014003641,
-0.027585404,
-0.035791617,
0.015350929,
0.00057710585,
-0.011043687,
-0.024196766,
0.0015182518,
0.018671522,
-0.0025057534,
0.0021178976,
0.015650328,
-0.014765744,
-0.0015871474,
-0.030538552,
0.008294674,
0.00041528654,
0.026755255,
0.00024559957,
-0.014616045,
0.014779353,
0.0026418434,
0.008818619,
-0.009539896,
-0.034485158,
0.032743208,
-0.016466867,
-0.030674642,
0.0063587963,
0.009580722,
0.012962554,
0.023271356,
0.0469782,
0.0053075026,
-0.034349065,
-0.011669701,
0.014194166,
0.014588827,
-0.003691436,
0.020127682,
0.008131366,
0.03658094,
-0.016534911,
0.0071787373,
0.012574698,
-0.0025074547,
-0.026782474,
0.0025942118,
0.007049452,
-0.0049196463,
0.023271356,
-0.004552204,
-0.00794084,
0.008825424,
0.02871495,
-0.0073080226,
0.008451177,
0.031137347,
0.033423655,
0.0063553937,
0.007423699,
-0.011479175,
-0.011234214,
0.011771768,
0.001986911,
-0.011969098,
-0.017120097,
0.04444693,
-0.01735145,
-0.007117497,
-0.035328913,
0.013098644,
-0.00430384,
-0.004113314,
-0.016466867,
-0.001221406,
0.0029531487,
-0.007423699,
-0.020590387,
-0.009022754,
-0.01947445,
-0.021706324,
-0.019569714,
-0.011322672,
0.011186582,
-0.014343865,
-0.009383392,
0.008777793,
-0.02080813,
-0.005052334,
0.008015689,
0.028388333,
0.0032457418,
0.013418455,
-0.0027660253,
-0.008961514,
0.03900334,
-0.010893988,
-0.018399341,
0.008682529,
-0.037234172,
0.024128722,
0.011839813,
0.0036982405,
0.001957992,
-0.027871192,
0.018930092,
0.008961514,
-0.009526286,
0.016915962,
-0.0011133847,
0.00069278217,
0.009934556,
0.031001257,
0.036744248,
-0.019406406,
-0.032498244,
-0.025571274,
-0.003555346,
-0.02656473,
-0.01341165,
-0.0074781347,
-0.02480917,
-0.0016398821,
0.005627313,
-0.007369263,
-0.017923027,
0.0018014888,
-0.009832488,
-0.009335761,
-0.00544019,
0.020114074,
0.0038207213,
-0.0037730897,
0.003650609,
0.024768345,
0.0046440647,
-0.0035825642,
-0.01441191,
0.018004682,
0.0125338705,
-0.018970918,
0.00088203204,
-0.0013107149,
-0.0073488494,
-0.016181078,
-0.021325272,
-0.009403805,
0.027027436,
-0.0055320505,
-0.015323712,
-0.047985263,
-0.005484419,
-0.006995016,
0.021080311,
0.020658432,
-0.015391757,
-0.013649807,
0.017147316,
-0.0050047026,
-0.019107008,
0.014548,
-0.028333897,
-0.017487539,
0.024877217,
-0.005270078,
0.029885322,
0.004620249,
-0.000118121694,
-0.013323192,
-0.007886404,
-0.01521484,
-0.025693756,
0.009036363,
-0.002208057,
0.045426775,
0.040609196,
0.035709966,
-0.02817059,
-0.0043718847,
0.006967798,
0.008505613,
0.029994193,
-0.004912842,
0.026346985,
-0.011622069,
0.0112138,
0.013649807,
-0.011070905,
0.009505873,
-0.025244659,
0.00054563506,
0.010825944,
-0.020359036,
-0.021039484,
0.00006209097,
-0.0014493564,
-0.03750635,
0.023870151,
0.0013294272,
0.011792181,
-0.027041044,
0.0079272315,
0.029150436,
0.0109280115,
0.028007282,
0.002983769,
0.028116154,
-0.0035111168,
-0.003915984,
-0.01947445,
-0.0033495103,
-0.018113554,
-0.022726998,
0.000087129374,
0.00312156,
0.0077979458,
0.022876697,
-0.010186322,
0.0050217137,
0.00033405793,
-0.004640662,
0.0005162907,
-0.021747151,
-0.00644045,
-0.033314783,
-0.021012265,
-0.025938716,
-0.027544577,
-0.027612621,
-0.014166948,
-0.0009118017,
0.0089411,
-0.008798206,
0.016589347,
-0.01482018,
-0.015636718,
0.020944221,
-0.020998657,
0.013860746,
-0.012424999,
0.017392278,
0.019079791,
0.0028782994,
-0.016711827,
-0.017582802,
-0.0028936095,
0.012064361,
0.023421055,
0.020998657,
-0.0032967755,
-0.029041564,
0.007634638,
-0.0076142247,
-0.0052292505,
-0.056939974,
0.019787457,
-0.006926971,
-0.00198521,
-0.016330777,
-0.020903394,
-0.026850518,
0.0037458718,
-0.009301738,
0.011601656,
-0.0071515194,
0.0006876788,
-0.013248342,
0.003875157,
-0.010485719,
0.025258267,
-0.017827764,
-0.02562571,
-0.0020430482,
-0.013105448,
-0.0037288605,
-0.015105968,
0.004718914,
0.017337842,
0.023176095,
0.0068385126,
0.009914142,
-0.011465566,
0.016575739,
-0.0017325933,
-0.0020855763,
0.05029879,
-0.009641963,
0.0008543888,
0.0075053526,
0.014942661,
-0.011656092,
-0.015187622,
-0.008757379,
-0.010267976,
-0.025557665,
-0.0038989729,
0.028524423,
0.02480917,
-0.031137347,
0.0073216315,
-0.008893468,
-0.0051714126,
-0.0071719326,
-0.011349889,
-0.00091520394,
-0.022944741,
0.002332239,
0.000597094,
-0.012540676,
0.015704764,
-0.004783557,
0.006923569,
-0.0056987605,
0.01775972,
-0.04537234,
0.019977983,
0.0039636157,
0.007934036,
-0.008063321,
-0.0031708924,
-0.027925627,
-0.030892385,
0.000008605288,
0.010091059,
-0.035029516,
-0.031845015,
-0.019365579,
-0.005025116,
0.014983487,
-0.016698219,
0.03326035,
0.005756599,
0.021815196,
-0.0040894984,
-0.006096823,
-0.004960473,
0.0028136566,
-0.0034090495,
0.010125081,
0.00050013,
-0.007437308,
0.0125951115,
0.007920426,
0.0085328305,
-0.0060559963,
-0.026673602,
-0.01668461,
0.029259307,
0.007396481,
-0.0014204374,
-0.007981667,
0.011227408,
-0.026578339,
0.02321692,
0.008457981,
-0.029667577,
-0.016194686,
0.0055864863,
0.0037356652,
-0.00494006,
-0.019460842,
0.0040282584,
0.010948425,
-0.015065141,
-0.041289646,
-0.009655572,
-0.041997313,
0.040228147,
-0.00410651,
-0.007995276,
-0.03241659,
0.024482556,
-0.052503448,
0.0032457418,
0.018440168,
-0.008206215,
0.0040486716,
0.021175573,
0.001748754,
0.016085815,
-0.011894248,
0.003359717,
0.016630175,
-0.022495644,
-0.0012962554,
-0.025190223,
0.022495644,
0.027177135,
-0.036553722,
-0.03296095,
0.010751095,
-0.009002341,
-0.014371083,
0.010308803,
-0.0010232253,
0.013255147,
0.00331889,
0.004460343,
-0.03590049,
0.021243619,
0.008131366,
-0.023910979,
0.009308543,
0.016521303,
-0.016698219,
-0.018154379,
-0.008226628,
0.0040554763,
0.014765744,
0.01774611,
0.009730421,
-0.02695939,
-0.010152299,
-0.011833008,
0.022999177,
0.015623109,
-0.015269276,
0.010465306,
-0.022250682,
-0.02001881,
-0.010771508,
0.006705825,
0.012663156,
0.005093161,
-0.0071311058,
-0.0039329953,
0.0045590084,
0.018794002,
0.0098052705,
-0.011948685,
0.005038725,
-0.0058348505,
0.008628094,
-0.013581762,
-0.006113834,
0.0014680688,
-0.018617086,
-0.01814077,
-0.016276341,
-0.017868591,
-0.020535951,
-0.0048958305,
0.0038241234,
-0.011336281,
-0.010070645,
-0.0048924284,
-0.0092609115,
0.009220084,
0.007124301,
-0.0076686605,
-0.023516318,
0.016317168,
0.18649746,
-0.024754735,
0.011098123,
-0.00200052,
0.0059879515,
-0.010689854,
0.009349369,
-0.005426581,
-0.009975383,
0.006603758,
0.02148858,
-0.010451697,
-0.0018116955,
-0.009628354,
0.0014842295,
-0.0109280115,
-0.009294934,
-0.015514238,
-0.026850518,
0.0045896284,
0.00013226228,
0.013323192,
0.020222945,
-0.00034724164,
0.023053613,
0.0035043124,
-0.0061920863,
0.015500628,
0.003053515,
0.0073760673,
-0.035274476,
0.020386253,
0.01094162,
0.0090771895,
0.0063928184,
0.0070562563,
-0.014017249,
-0.014030859,
0.017541977,
0.0020498526,
-0.0031981105,
0.007314827,
-0.022087375,
-0.002885104,
-0.0032831666,
0.018031899,
0.0042357952,
-0.006705825,
-0.0015658833,
0.011390717,
-0.008954709,
-0.020780914,
0.011159364,
0.020318208,
0.0043888963,
-0.0022863087,
0.024659472,
0.020985048,
0.002345848,
0.028932692,
-0.020467907,
-0.013193906,
-0.020740086,
0.028088935,
-0.009220084,
0.017963855,
-0.000044521566,
-0.0035179215,
0.005300698,
-0.024877217,
-0.0035757597,
0.011492784,
-0.010955229,
-0.005219044,
0.010825944,
-0.0024496166,
0.019610541,
0.03644485,
0.006579942,
0.017038444,
0.013302778,
0.0050999653,
-0.02016851,
0.006263533,
-0.016249122,
-0.009492264,
0.018589867,
0.0013991733,
-0.026210897,
0.0017912821,
0.013962814,
-0.011030079,
-0.026945781,
-0.009526286,
0.015242058,
0.00047759016,
-0.0037424697,
-0.007934036,
-0.0029259308,
-0.008900274,
-0.034893427,
0.07822442,
0.014833788,
0.009152039,
-0.010118277,
0.023856543,
-0.013459282,
-0.010723877,
-0.00015448319,
-0.0035791618,
0.008995536,
-0.02964036,
-0.0015361137,
-0.012159624,
0.0010036624,
0.02495887,
0.0020872774,
-0.016616564,
0.033723053,
0.009145235,
0.019433623,
-0.032715987,
-0.014479955,
0.012513458,
0.004150739,
0.017256187,
-0.019664977,
0.010206736,
0.0045692152,
-0.04069085,
-0.012860486,
0.0031572834,
-0.009716812,
0.010084255,
-0.0014110812,
-0.005984549,
-0.0029480453,
-0.02001881,
-0.029422615,
0.0245506,
-0.0072263684,
0.0027013826,
0.0032457418,
0.0012622329,
0.008587266,
-0.0155958915,
0.025244659,
0.022754215,
-0.013799506,
-0.014724917,
-0.012111993,
-0.025462402,
-0.025339922,
-0.0070562563,
0.019705804,
-0.014248602,
-0.0114723705,
-0.010356434,
-0.008233434,
0.030075846,
-0.0403098,
0.0051884237,
0.03391358,
0.001986911,
-0.0058348505,
-0.016153859,
-0.17256187,
0.007818359,
0.0190934,
-0.013738265,
0.034893427,
-0.0006506794,
0.0049026352,
0.0010861667,
-0.020046027,
0.005232653,
0.024414511,
0.022672562,
-0.019705804,
-0.0112138,
-0.006260131,
0.0018202012,
-0.01614025,
0.043575954,
0.019746631,
0.0040214537,
0.024727518,
-0.025652928,
0.0068351105,
-0.036825903,
0.0012988071,
0.013772288,
0.006756859,
-0.03391358,
0.005103368,
-0.008961514,
-0.011778573,
-0.00707667,
0.032198846,
-0.0014485059,
0.015663937,
-0.0026418434,
-0.014343865,
0.0007995276,
-0.0028527826,
0.023774888,
0.029994193,
0.018617086,
0.008253846,
-0.00013226228,
-0.029177655,
0.025421575,
0.010703463,
0.0004397402,
0.025789019,
-0.01709288,
0.008396741,
0.005150999,
-0.0015046429,
0.011070905,
0.02750375,
0.019120617,
0.02321692,
0.025203831,
-0.014643263,
0.0041031074,
-0.014303039,
-0.017405886,
0.021066701,
-0.009186062,
0.004120119,
-0.022332337,
0.0048107747,
0.0030484116,
0.007219564,
0.012656352,
-0.032498244,
0.018521823,
-0.018535431,
-0.00008968105,
0.010043427,
0.008655312,
-0.0075189616,
-0.0030279981,
0.013758679,
-0.020032419,
-0.014752135,
0.00577361,
-0.024890825,
-0.00024007092,
0.014316647,
0.017365059,
0.0059062974,
0.019937156,
-0.009485459,
0.0010342825,
0.013064621,
-0.021434145,
0.0058076326,
-0.010254366,
-0.0005490373,
0.037070863,
0.009029559,
-0.004320851,
0.0010385353,
-0.00091435335,
0.0041303257,
-0.023407446,
-0.01683431,
-0.0008526877,
0.0121392105,
-0.0039193863,
-0.016793482,
-0.012874096,
0.011302258,
-0.00023475492,
-0.017610021,
0.009669181,
0.017228968,
0.03189945,
0.00094752526,
0.020331817,
-0.00328827,
0.0032457418,
0.010764703,
-0.036526505,
0.063962206,
0.0037288605,
-0.0022846076,
0.015160404,
-0.0055286484,
-0.02480917,
-0.14414632,
-0.022509253,
0.016657392,
-0.025435185,
-0.022318728,
0.010669441,
0.002582304,
0.019869111,
-0.032062758,
0.0049060374,
-0.019651368,
-0.013561349,
-0.0017206855,
-0.026864128,
-0.008485199,
0.010104668,
-0.0015990552,
-0.0029293331,
-0.017147316,
0.018372124,
0.006151259,
-0.005164608,
0.008934296,
-0.0049060374,
-0.001159315,
0.007566593,
-0.014561609,
0.032362156,
0.005814437,
0.025870671,
0.0067092273,
0.00447055,
0.009968578,
0.008845837,
-0.007219564,
0.0042255884,
-0.017718893,
-0.025693756,
0.04218784,
-0.0021195987,
-0.00017957475,
0.0010419376,
-0.0013625992,
0.014003641,
0.0108667705,
-0.011431543,
-0.014956269,
-0.001929073,
0.036717027,
-0.026374204,
-0.014833788,
-0.048774585,
-0.03535613,
-0.0006647136,
0.023366619,
0.011588047,
-0.0039227884,
0.018902874,
-0.00328827,
-0.007587007,
0.028851038,
-0.016385213,
-0.009029559,
-0.0048754173,
0.016589347,
-0.028061718,
0.013636198,
-0.022890305,
0.017378667,
-0.028252244,
0.0010461904,
-0.013738265,
-0.015677545,
-0.012282105,
-0.008070125,
0.0032100182,
-0.017433103,
-0.036499284,
0.021202791,
-0.02162467,
-0.019311143,
-0.00041528654,
0.017174533,
-0.004916244,
0.0480397,
0.004807372,
-0.010540156,
0.0063417847,
-0.0071311058,
-0.0056545315,
-0.004293633,
0.022536471,
-0.007097083,
-0.029177655,
0.0011389016,
0.012336541,
-0.017487539,
-0.011506393,
0.021679105,
0.023176095,
-0.005916504,
-0.013649807,
-0.05563351,
0.01816799,
-0.001568435,
0.0049094395,
0.0070290384,
-0.018766783,
0.011315867,
-0.008185802,
0.014629654,
0.0012860487,
-0.029939758,
0.013670221,
-0.0016135147,
0.019011745,
-0.0062090973,
-0.016534911,
0.025571274,
0.006232913,
0.017678065,
0.021447754,
-0.0063485894,
0.0004720615,
0.02535353,
0.014221384,
0.00080973434,
0.0009687893,
-0.0027098882,
0.035138387,
-0.0157592,
-0.02016851,
-0.0050421273,
-0.020794522,
-0.009288129,
0.008539635,
-0.0026265332,
-0.00410651,
0.008226628,
0.04096303,
0.019011745,
0.02256369,
-0.02495887,
-0.05310224,
0.023529926,
-0.0045624105,
-0.0012783936,
-0.011268236,
-0.035410568,
0.01415334,
0.007906818,
-0.007566593,
0.021951286,
0.01441191,
-0.007328436,
-0.039493263,
-0.017800547,
0.009710007,
0.015500628,
-0.017637238,
-0.038567852,
-0.022264292,
0.017854983,
0.03097404,
-0.0053619384,
-0.0011286949,
-0.0021281042,
-0.016562128,
-0.022985568,
-0.0048413947,
0.02483639,
-0.025407966,
-0.02404707,
0.020889785,
0.0062090973,
-0.006300958,
0.014874616,
-0.002041347,
-0.019515278,
0.010281584,
0.003888766,
0.02215542,
0.0047291205,
-0.0017793742,
-0.03268877,
0.0052122395,
0.02415594,
0.0066309758,
-0.0010232253,
0.0019494864,
0.002723497,
-0.016507693,
0.0013821621,
0.016739046,
-0.0026265332,
0.029068783,
0.006270338,
0.039329953,
0.014888224,
-0.006583344,
-0.00046653286,
0.046107225,
0.012118797,
0.0014782755,
0.0007999529,
-0.020059638,
-0.019066181,
0.010791921,
-0.04338543,
-0.025680145,
-0.023992632,
0.005957331,
-0.004133728,
-0.002983769,
0.010492524,
0.00041826352,
-0.030538552,
0.023040004,
-0.0010317308,
-0.017024834,
-0.014956269,
0.029531488,
0.008526026,
0.015350929,
-0.011887444,
-0.0024394097,
-0.0058484594,
0.005481017,
0.016371604,
-0.04207897,
0.009417415,
-0.00090925,
0.0094106095,
-0.0035111168,
-0.025557665,
-0.00058178394,
-0.009716812,
-0.021842413,
0.023611581,
0.02338023,
-0.019528886,
0.075774804,
0.009995796,
0.015174014,
0.0029395397,
-0.0128060505,
0.02054956,
0.017610021,
0.035410568,
-0.0025142592,
-0.020032419,
0.013751875,
-0.0040588784,
0.03802349,
-0.04028258,
-0.046624366,
0.023597972,
-0.008954709,
-0.0010325814,
0.008036103,
-0.011315867,
0.014656872,
0.0021417134,
0.0074713305,
-0.012710787,
-0.028388333,
0.0060253763,
0.014289429,
-0.022863086,
-0.008553244,
-0.04392979,
0.0011601655,
-0.013085035,
-0.038404543,
-0.02789841,
0.022005722,
-0.020944221,
-0.029722013,
-0.008437567,
-0.003946604,
-0.0027796342,
0.00594032,
0.03549222,
-0.028197808,
-0.025911499,
-0.012370563,
0.016085815,
-0.035682745,
0.0019750032,
-0.0020379447
] |
Melatonin has been speculated to be mainly synthesized by mitochondria. This speculation is supported by the recent discovery that aralkylamine N-acetyltransferase/serotonin N-acetyltransferase (AANAT/SNAT) is localized in mitochondria of oocytes and the isolated mitochondria generate melatonin. We have also speculated that melatonin is a mitochondria-targeted antioxidant. It accumulates in mitochondria with high concentration against a concentration gradient. This is probably achieved by an active transportation via mitochondrial melatonin transporter(s). Melatonin protects mitochondria by scavenging reactive oxygen species (ROS), inhibiting the mitochondrial perme
|
[
-0.00865995,
-0.032119125,
0.00048521382,
-0.027259678,
-0.029052736,
0.022049416,
-0.039213397,
-0.01025811,
-0.028039267,
0.0024053613,
0.031417493,
0.015228,
-0.009900798,
-0.013993648,
-0.00919267,
-0.0126423575,
0.04532019,
0.0063309236,
-0.020360302,
0.00009531711,
-0.0067369603,
0.008250665,
-0.005603306,
-0.0059183906,
0.03884959,
0.016488338,
0.01222008,
-0.049685895,
-0.010550457,
-0.013668818,
0.011356033,
-0.0023290263,
-0.023673562,
-0.0052687316,
-0.019632686,
-0.018528266,
-0.004388444,
-0.016982079,
0.0029608193,
0.0039596697,
0.017839627,
-0.004385196,
0.00035447002,
0.002600259,
0.012414977,
0.011674366,
0.0041675605,
-0.01269433,
-0.0042357747,
0.030793821,
0.008497535,
0.011297564,
-0.003975911,
-0.0042455196,
-0.02403737,
-0.015137047,
-0.00038735897,
-0.011375523,
0.0037712685,
-0.009004269,
0.010206138,
-0.007139749,
-0.028481036,
0.024803968,
0.017631736,
0.010777838,
-0.007867366,
-0.006311434,
0.0019798349,
-0.0031248583,
0.041812032,
0.009920288,
0.001405699,
0.0076984554,
0.022919958,
-0.022335265,
-0.029338585,
-0.008172706,
-0.0050705858,
-0.015098068,
0.025466619,
-0.0008035466,
-0.02980634,
0.050699364,
-0.004385196,
0.01461732,
-0.018775135,
0.028221173,
0.01298018,
0.024635056,
0.009511003,
0.008094747,
0.0340681,
0.00485295,
-0.01985357,
0.013136098,
0.0021292563,
0.028844845,
-0.02411533,
-0.015916638,
-0.006067812,
0.004316982,
-0.0134739205,
-0.022179347,
-0.047113247,
-0.009088725,
0.0073216534,
0.008296141,
0.011745829,
-0.016124528,
0.0035243982,
0.03050797,
-0.010959742,
-0.03393817,
-0.024128323,
0.006801926,
0.022569142,
-0.007406109,
-0.013577866,
-0.008497535,
0.016150514,
0.03762823,
0.005388919,
-0.027753418,
0.024505125,
0.025375668,
0.0005790083,
-0.011485965,
-0.016358405,
-0.009218656,
-0.026129272,
0.0028487532,
-0.016696228,
0.015955618,
-0.030533958,
0.01743684,
-0.031833276,
-0.014513374,
-0.0039044486,
-0.023361726,
0.003475674,
0.005648782,
-0.032768782,
0.009082228,
-0.0026165002,
0.028143214,
0.025843421,
0.020334316,
-0.0073216534,
0.03050797,
-0.007808897,
-0.027805392,
-0.008055768,
-0.015292965,
0.005353187,
0.03487368,
-0.010427021,
0.016943099,
-0.032768782,
-0.021581661,
0.03427599,
-0.025544578,
0.025271723,
-0.004352713,
0.010420525,
0.029494504,
0.01031658,
-0.0069383546,
-0.0021081425,
-0.019515747,
-0.0022803019,
0.019879555,
-0.003378225,
0.03165137,
-0.019801596,
0.037862107,
0.0036348403,
0.004021387,
-0.010927259,
-0.0005481495,
-0.0045898384,
-0.0030972478,
0.016124528,
-0.018801121,
-0.0032596623,
0.012512426,
0.016527317,
-0.020191392,
0.018697176,
-0.024310227,
-0.023556624,
-0.007185225,
-0.0222703,
-0.027129747,
-0.62783015,
-0.02301091,
-0.0013691556,
-0.015734732,
0.01355188,
0.0077764145,
0.015955618,
0.002293295,
0.0017427094,
0.022997918,
-0.009900798,
0.0315994,
0.021451728,
-0.023972405,
0.008517025,
-0.024726009,
-0.017514797,
-0.0126358615,
0.011239095,
-0.012648854,
-0.034587827,
-0.004096098,
0.010069709,
-0.003266159,
0.00003540132,
0.016189493,
0.009498009,
-0.0054441397,
-0.01404562,
0.04318931,
-0.021438736,
0.027623486,
-0.0019441036,
0.019009013,
0.056078535,
-0.01383773,
-0.015046095,
0.035367418,
-0.011369026,
0.01547487,
-0.016202487,
-0.014487389,
0.035913132,
-0.01490317,
-0.01977561,
0.011297564,
0.012401984,
-0.013967661,
-0.00841308,
-0.026077298,
0.006012591,
-0.0013090622,
-0.015487863,
0.018892074,
-0.01437045,
0.02088003,
0.023036897,
-0.0216986,
-0.007263184,
0.02592138,
-0.0069578444,
0.022686081,
0.010953245,
-0.031209603,
-0.012609875,
0.005814445,
-0.01326603,
0.0026278694,
-0.008042774,
-0.014058613,
0.0061879987,
0.030456,
-0.03271681,
0.009926785,
0.009692907,
0.018086497,
0.020970982,
-0.008867841,
-0.02514179,
0.025492607,
0.0026294934,
0.002114639,
-0.013642832,
-0.031963207,
0.052544393,
-0.011018211,
-0.0067694434,
0.02845505,
0.0121746035,
0.0017540784,
-0.0048561986,
0.002658728,
0.0075230473,
-0.027155733,
-0.0112520885,
0.00023265902,
-0.0023306506,
0.0030712613,
-0.001737837,
-0.019918535,
-0.030923752,
0.0113430405,
0.0014982753,
-0.00788036,
0.02460907,
-0.022738053,
-0.043657064,
-0.020074453,
0.02993627,
-0.021269824,
-0.0012757672,
-0.0067174705,
-0.01948976,
-0.013434941,
0.0031963207,
-0.016046569,
0.019593706,
-0.0009574345,
0.008348114,
-0.01863221,
0.006951348,
0.016813166,
-0.0015673016,
0.0038134963,
0.007919339,
0.0030062955,
0.0149551425,
-0.026973829,
-0.012388991,
-0.009153691,
-0.017423846,
0.006343917,
0.008055768,
0.0031216098,
0.030715862,
0.022880979,
0.037316393,
-0.008685936,
0.022517169,
-0.015331944,
-0.026921855,
-0.0032710314,
-0.021685606,
0.0043234783,
-0.01838534,
-0.012492936,
-0.0146563,
0.00014414302,
-0.0199835,
0.0062692063,
-0.0125514055,
0.011141647,
-0.03087178,
0.008627467,
0.021412749,
-0.014916163,
-0.010647906,
-0.036952585,
-0.010381546,
0.009270629,
0.0076269927,
0.039369315,
-0.022556148,
0.023686554,
-0.01383773,
-0.0071917213,
0.0068928786,
0.0037550272,
-0.01113515,
-0.03632891,
-0.011576918,
-0.013694805,
-0.003220683,
0.024453152,
0.0037940065,
0.02571349,
0.0026181245,
-0.016189493,
-0.008653454,
0.0054733744,
0.00080801296,
-0.0059963497,
0.007614,
-0.008237672,
0.0012895725,
0.022166355,
0.033418443,
0.010998721,
-0.007497061,
0.02923464,
-0.0075100544,
0.03258688,
0.0035536329,
0.0025758967,
-0.005447388,
-0.03890156,
0.0032271794,
0.00845206,
0.00031833275,
0.023920432,
-0.0073671294,
-0.011336544,
0.015526842,
-0.04373502,
0.011745829,
-0.0052232556,
-0.012798276,
-0.016722213,
-0.0021617392,
-0.00582419,
0.0039791595,
-0.014071607,
-0.010855797,
-0.018619217,
0.0005781962,
0.011200115,
-0.005129055,
0.009069235,
0.008068761,
-0.026259204,
0.011849774,
-0.0011986203,
-0.006379648,
-0.0037810134,
-0.012285045,
0.013733785,
0.0134739205,
-0.0054019117,
-0.0052947183,
-0.0053207045,
-0.0047490047,
-0.01111566,
-0.003829738,
-0.005060841,
0.025063831,
0.0073801223,
-0.006256213,
-0.004628818,
0.050257593,
0.01985357,
-0.0106024295,
0.0025222998,
0.0030842545,
-0.01140151,
0.0035633778,
-0.011817291,
0.017696703,
0.0075035575,
0.008068761,
0.0046125767,
-0.011349537,
-0.0000980071,
-0.023816487,
-0.004761998,
0.006025584,
0.0033912184,
0.003875214,
0.020230372,
0.023348732,
0.011453482,
0.030767834,
0.009543486,
-0.022413224,
-0.019009013,
-0.0054896157,
0.0199835,
0.031287562,
0.011849774,
0.011518449,
-0.015124054,
-0.0110701835,
0.014539361,
0.018372348,
-0.029962258,
0.030248107,
0.0029965506,
-0.010634912,
0.043838967,
0.017943572,
0.0056715203,
-0.045138285,
-0.04004496,
0.026999814,
0.010855797,
-0.037992038,
-0.026025327,
-0.034587827,
0.00078121456,
-0.015137047,
0.018775135,
-0.011336544,
-0.0018921308,
-0.018723164,
-0.010537463,
-0.010446511,
-0.030637903,
0.024842948,
-0.038018025,
0.019996494,
-0.009472024,
-0.010498484,
0.0026294934,
-0.018164456,
-0.0019392312,
0.024089344,
-0.0032353,
-0.008062264,
-0.0071917213,
0.0028828604,
-0.012986677,
-0.0034626806,
-0.010303587,
0.021841524,
-0.017449832,
-0.024803968,
0.0050543444,
0.004537866,
0.009569473,
0.005889156,
0.0033489903,
-0.013525894,
-0.028325118,
0.0055870647,
0.0028000288,
0.028117226,
0.0163714,
-0.015059088,
0.026791923,
0.009199167,
0.014526368,
-0.0002702174,
-0.028143214,
0.011433993,
-0.008328624,
0.0042844987,
-0.017852621,
0.026506074,
0.0030810062,
0.007256687,
0.0073021636,
-0.013694805,
-0.0043234783,
-0.0041155876,
-0.003641337,
0.02095799,
-0.037940066,
0.0051095653,
0.038251903,
0.044072844,
-0.018255409,
0.012622868,
0.025973354,
0.015630787,
-0.020126425,
0.022738053,
-0.007094273,
-0.007399612,
0.01086879,
-0.01863221,
-0.010154165,
-0.0049081715,
0.028533008,
0.0061425227,
0.013272527,
0.013668818,
0.023205807,
0.009290119,
0.001893755,
0.00515829,
-0.02091901,
0.013733785,
-0.012687834,
-0.005788459,
0.0015673016,
-0.00047668704,
-0.008601481,
-0.016735207,
-0.0108817825,
-0.004518376,
-0.0011344665,
-0.035731226,
0.01490317,
-0.0021990945,
0.0050445995,
-0.00974488,
-0.0016371398,
0.03427599,
-0.019190917,
0.016644254,
0.0041058427,
0.0013821488,
-0.013064636,
-0.039239384,
0.00230304,
0.014279498,
-0.009666921,
-0.044020873,
-0.0077699176,
0.035601296,
0.031131644,
0.014825211,
-0.03328851,
0.00839359,
0.032249056,
-0.011635386,
-0.016475344,
-0.020438261,
-0.019216903,
-0.0028666188,
0.0016103415,
0.019918535,
-0.037992038,
-0.0029299606,
-0.024531111,
0.026765937,
0.0046677976,
0.012213583,
-0.010375049,
0.00036076357,
0.011167632,
0.019749623,
0.047321137,
-0.006093798,
-0.0011791305,
0.006200992,
-0.040798564,
0.0287409,
-0.01948976,
0.015773712,
-0.006480345,
-0.01086879,
0.0035731227,
-0.006558304,
-0.0032466692,
0.006155516,
0.003774517,
0.0060743084,
0.0010256487,
0.002335523,
0.001760575,
-0.03783612,
0.05618248,
-0.00435921,
0.0067174705,
-0.011310558,
-0.013616846,
0.030040218,
0.003511405,
-0.004154567,
0.009523996,
0.005853425,
0.011408006,
-0.0281692,
0.01111566,
0.015825685,
0.028870832,
-0.021139894,
-0.06668097,
-0.009283623,
-0.0033749768,
-0.024972878,
0.0061295293,
0.0071137627,
0.0002777291,
0.003046899,
0.009575969,
-0.02293295,
0.0048204674,
0.036172993,
-0.028688926,
-0.008426073,
-0.011330048,
0.021464722,
0.021633634,
-0.00611004,
-0.022945944,
-0.024414172,
-0.013434941,
-0.0021243838,
-0.018086497,
-0.02194547,
-0.011472972,
0.03391218,
0.009809846,
0.010771341,
0.002202343,
-0.0075100544,
0.014838204,
0.0005063277,
-0.0025352929,
-0.03412007,
0.03926537,
-0.0131036155,
0.019593706,
-0.004018139,
-0.006996824,
0.031495452,
-0.006210737,
-0.0013431692,
0.02194547,
-0.0013675315,
-0.024323221,
-0.007750428,
-0.017332893,
-0.028792873,
0.031885248,
-0.011219605,
0.00757502,
-0.03484769,
-0.010063212,
0.046437602,
0.019151937,
0.02628519,
-0.024414172,
0.029260626,
-0.028117226,
0.0205552,
-0.0011815667,
-0.009335595,
-0.0051355516,
-0.004316982,
0.011986203,
-0.007750428,
0.020711118,
-0.004063615,
-0.006454359,
0.028117226,
-0.021763565,
0.026545053,
-0.00040664573,
-0.012785283,
0.010517973,
-0.0027821632,
-0.01324654,
-0.006431621,
-0.00018200594,
-0.03131355,
-0.04659352,
0.02034731,
0.02993627,
-0.008536515,
0.009608451,
-0.015305959,
-0.0103230765,
0.027987296,
-0.008835358,
0.0293126,
-0.010686886,
0.016410379,
-0.0118952505,
0.0043559615,
-0.010745354,
0.010407532,
-0.008192196,
-0.0029949264,
0.03037804,
0.010336069,
-0.019294862,
-0.025102811,
0.014227525,
0.010290593,
-0.02710376,
-0.027129747,
0.021009961,
0.008523522,
0.020178398,
-0.02095799,
0.0030582682,
-0.001373216,
0.019632686,
-0.0073476397,
-0.0053304494,
0.016085548,
0.00017814859,
-0.027831377,
0.029416544,
0.02628519,
-0.0024735753,
0.0030387784,
0.00420654,
0.010693382,
0.0043104854,
-0.006347165,
-0.0021227598,
-0.0050088684,
0.02514179,
-0.011024708,
0.010160661,
0.012583888,
0.006343917,
0.0052947183,
-0.016891126,
-0.024674036,
0.042721555,
0.0084715495,
0.014318477,
0.019268876,
0.0122720525,
0.0008226303,
0.00077471795,
0.0047684945,
0.0010232124,
-0.020256357,
-0.01891806,
0.016982079,
0.019684657,
-0.016488338,
0.00542465,
-0.005382422,
-0.009939778,
-0.024907913,
-0.014747252,
-0.004862695,
-0.024245262,
-0.005012117,
0.0049536475,
0.0034139564,
0.013720791,
-0.014773238,
-0.018398333,
-0.015098068,
0.0006281387,
0.00917318,
0.009595458,
0.024713015,
0.0023079123,
-0.010368552,
-0.014292491,
-0.000974488,
-0.038095985,
0.022660095,
-0.018827109,
-0.040564686,
0.0015096443,
0.0038849588,
0.017241942,
-0.0025320447,
-0.023712542,
-0.0037387856,
-0.010725864,
0.0070033204,
0.0055870647,
-0.012388991,
0.012401984,
-0.034327965,
0.018762143,
-0.005460381,
0.014201539,
-0.009465527,
-0.010206138,
-0.011369026,
-0.0036283436,
-0.02116588,
0.015916638,
-0.011459979,
0.014695279,
-0.0028032772,
-0.012947697,
0.01592963,
-0.016033577,
-0.013590859,
0.009549983,
-0.010121682,
-0.0032824005,
-0.027129747,
0.0055740713,
0.031547423,
0.00086323393,
-0.005827438,
0.0019116206,
-0.0049536475,
-0.032560892,
-0.008932807,
-0.015448883,
0.006496587,
0.013928682,
0.011635386,
-0.031495452,
0.0148641905,
-0.018320374,
-0.03762823,
-0.018515272,
0.009543486,
0.017839627,
-0.0035958607,
0.030793821,
0.002260812,
0.0021633634,
0.008594984,
0.009640935,
-0.016072556,
-0.018203435,
0.024985872,
-0.017125003,
0.047113247,
-0.005736486,
-0.042929444,
-0.0075230473,
0.033964157,
-0.019905541,
-0.044930395,
0.038069997,
0.0025401653,
-0.002247819,
-0.02538866,
0.026506074,
0.00082222425,
0.0005388107,
0.020659145,
-0.025973354,
-0.002601883,
-0.007971312,
0.004836709,
-0.011472972,
0.011453482,
0.0016988574,
0.020763092,
0.002832512,
-0.03479572,
-0.03505558,
0.019047992,
-0.00032482934,
-0.00090871006,
0.037316393,
0.0077894074,
0.015331944,
-0.0011888754,
-0.028610967,
0.0015811068,
-0.012869738,
-0.005827438,
0.0002292077,
0.015409904,
0.015916638,
0.014708272,
0.017670715,
0.009101718,
-0.03050797,
0.010076206,
-0.0070163137,
-0.012616372,
-0.024583085,
0.018775135,
0.008588487,
0.0018417824,
0.011888754,
-0.00008257771,
-0.0022104636,
0.008374101,
-0.00049983116,
0.006035329,
0.012388991,
-0.011102667,
0.01197321,
-0.019216903,
0.006015839,
-0.014968135,
-0.021529688,
-0.027649473,
0.0066070287,
0.18762143,
-0.008588487,
-0.016358405,
0.022569142,
0.0058826595,
0.011297564,
0.010271103,
0.008309134,
0.0015413152,
-0.008387093,
0.0275975,
0.009556479,
0.02084105,
-0.0031410996,
-0.011576918,
-0.018528266,
-0.019827582,
0.0054019117,
-0.017722689,
-0.018814115,
-0.008913317,
-0.016592283,
-0.00033761948,
-0.02165962,
0.009926785,
0.018619217,
0.006369903,
-0.011791305,
-0.010751851,
-0.007620496,
-0.0053207045,
-0.022686081,
-0.004794481,
-0.012044672,
0.012785283,
-0.020932002,
-0.023842473,
-0.0052070143,
0.005317456,
-0.0011498958,
-0.026713964,
0.014097593,
-0.023062883,
-0.014721265,
-0.01003073,
0.041084412,
-0.0076724687,
-0.007951822,
-0.026311176,
0.020854043,
-0.04573597,
-0.0022218328,
0.0327428,
0.014630313,
-0.007354136,
0.0027171974,
0.022647101,
0.012135624,
0.017488811,
0.040018976,
-0.038953535,
0.003089127,
-0.0053207045,
0.022608122,
-0.0041578156,
0.018827109,
-0.026051313,
-0.005038103,
0.051193103,
-0.02108792,
0.0030095438,
-0.021828532,
-0.011797802,
0.0157997,
0.0003843137,
-0.0051647862,
0.03632891,
0.018281395,
0.0050705858,
-0.014409429,
-0.010803823,
-0.0032742796,
-0.014643307,
-0.005622796,
0.010771341,
-0.03258688,
0.010894776,
0.014383443,
-0.008627467,
-0.004839957,
-0.0021682358,
-0.021529688,
0.013941675,
-0.009387568,
-0.0017800648,
-0.0036250954,
0.03201518,
-0.018892074,
-0.016774187,
-0.020542206,
-0.010836307,
0.035679255,
0.012337018,
0.016176501,
-0.022127375,
-0.007951822,
-0.016111536,
0.0115314415,
-0.0019392312,
-0.00013490568,
0.017631736,
-0.047918823,
0.0072436943,
-0.013318003,
-0.0039889044,
0.0022494432,
0.016280446,
-0.034094088,
0.023712542,
-0.015448883,
-0.012973684,
-0.030456,
0.022426218,
0.010446511,
-0.01191474,
-0.013694805,
-0.031105658,
0.00702281,
-0.0026960834,
-0.03087178,
0.007074783,
-0.011589911,
0.010089199,
0.029754367,
0.007497061,
0.006730464,
0.0069578444,
0.0014739131,
0.0126358615,
0.031963207,
-0.00008349129,
0.0016444485,
0.02030833,
-0.006879885,
-0.019801596,
-0.0069708377,
-0.007217708,
-0.014435416,
-0.024310227,
-0.017891599,
-0.022036422,
-0.03770619,
-0.005989853,
-0.005648782,
0.013954668,
0.010940252,
-0.019762617,
-0.039967,
-0.003865469,
0.030430011,
-0.0022169603,
0.0126423575,
0.0061717574,
-0.019047992,
-0.021997442,
0.013369976,
-0.16080351,
0.0022396983,
0.042903457,
-0.027181718,
0.03757626,
-0.00010455444,
0.0051875245,
0.012850248,
-0.0073346463,
-0.004099346,
0.03991503,
0.013577866,
-0.018515272,
-0.035523336,
0.017501805,
0.0016330795,
-0.009140697,
0.03443191,
0.020399282,
-0.004547611,
0.038225915,
-0.02440118,
0.017631736,
-0.025947368,
0.011213109,
0.01937282,
0.004664549,
-0.010537463,
0.0037485305,
0.0008624219,
-0.0071982183,
0.017267928,
-0.00011358876,
-0.004404686,
0.046047807,
0.00197009,
0.0055318438,
-0.00997226,
-0.0038167448,
-0.0014804096,
0.016800173,
-0.0035926125,
0.0005160726,
0.026791923,
-0.028584981,
0.023751521,
0.006629767,
-0.010953245,
0.014383443,
-0.04147421,
0.00365433,
0.0075035575,
0.008133726,
0.017293913,
0.0074320952,
0.0059833564,
0.011654876,
0.010758348,
0.00056763925,
-0.014032627,
0.0067824367,
-0.023452679,
0.025167776,
0.0010443263,
0.010816817,
-0.015981603,
-0.016982079,
0.00083481136,
-0.01058294,
0.0115314415,
-0.063770495,
0.001783313,
0.012278548,
-0.01924289,
0.02059418,
0.015344937,
-0.007854373,
0.021477716,
0.0014527992,
0.008530018,
-0.0013862092,
0.006918865,
-0.027805392,
-0.017060036,
-0.008952296,
-0.014526368,
0.010615422,
0.007516551,
-0.018151464,
0.023400705,
0.03515953,
-0.018476292,
0.010069709,
-0.043786995,
0.027415596,
-0.012317528,
0.035913132,
0.012194093,
0.0066265184,
0.0021877256,
0.028273145,
-0.015046095,
-0.0069578444,
0.003930435,
0.011180625,
0.012298038,
-0.00031366333,
0.0024963135,
0.024946893,
-0.025895394,
0.0034042115,
-0.009621445,
0.0076919585,
0.025596552,
-0.032093138,
0.01874915,
0.022958938,
-0.029000763,
-0.009569473,
-0.0019684657,
0.05399963,
0.011089673,
0.016709222,
0.013343989,
0.003012792,
-0.039733123,
-0.12192794,
-0.028403077,
-0.008744406,
0.02047724,
-0.0044826446,
0.012557902,
0.0211269,
0.035471365,
-0.0055708233,
0.039239384,
-0.011330048,
-0.009348588,
0.012902222,
0.0022429465,
0.0073411427,
0.006587539,
0.009575969,
-0.0015445634,
-0.022114381,
0.034483884,
0.001937607,
0.002778915,
-0.0073151565,
0.0074126055,
0.012142121,
-0.0028584981,
-0.017891599,
0.020711118,
0.010186648,
0.017696703,
-0.0012936328,
-0.006347165,
0.013980655,
-0.018398333,
0.0020350558,
-0.0062269783,
-0.013045146,
-0.004671046,
0.013889702,
-0.004164312,
-0.014019634,
0.010966239,
0.017293913,
-0.006821416,
0.01739786,
-0.0011320303,
-0.0025823931,
0.0016493209,
0.011784809,
0.010095696,
-0.016696228,
0.017150989,
-0.03677068,
-0.011570421,
0.031027699,
-0.013499907,
0.006788933,
0.015864665,
-0.021763565,
-0.019879555,
0.00867944,
0.005629292,
0.012317528,
-0.010693382,
0.039187413,
-0.010660899,
-0.0024297235,
-0.021594655,
0.010706374,
-0.030923752,
-0.00036116963,
0.024674036,
-0.01086879,
-0.015916638,
-0.013097119,
0.007685462,
-0.0076724687,
-0.0019018757,
-0.005889156,
-0.0057754656,
-0.034561843,
-0.006178254,
0.009809846,
-0.0073931157,
-0.009751377,
0.00039487067,
0.014006641,
0.007938829,
-0.011291068,
-0.015500856,
-0.02042527,
0.017579764,
-0.014747252,
-0.0020837802,
-0.016579289,
0.010816817,
-0.019022007,
0.012408481,
0.056754183,
0.010459505,
-0.009387568,
-0.047840863,
-0.048412565,
0.00871842,
0.02980634,
-0.004638563,
0.008068761,
-0.004109091,
0.027779404,
0.012070658,
0.010946749,
0.0028097737,
-0.0012838879,
-0.029676408,
-0.013168581,
0.00135129,
-0.01001124,
-0.013090623,
0.0037712685,
0.0097708665,
0.020944996,
0.01596861,
-0.023426691,
0.027701445,
-0.013785757,
0.027779404,
-0.018203435,
-0.00008465865,
-0.011999195,
0.0045671007,
-0.027363623,
-0.002525548,
0.031131644,
-0.013668818,
-0.012947697,
-0.005665024,
-0.05555881,
-0.029000763,
-0.011180625,
0.0119017465,
0.007945325,
0.010764844,
-0.024920907,
-0.0075685233,
0.0157997,
-0.004261761,
0.013980655,
0.00471977,
-0.024011385,
-0.013090623,
0.0022072154,
-0.013863716,
0.044150803,
0.014175552,
-0.0054214015,
-0.0021536185,
-0.023712542,
-0.012285045,
0.012967187,
0.0037550272,
-0.018866088,
-0.02746757,
-0.00784138,
0.009225153,
0.0072371974,
0.0003577183,
-0.015228,
-0.004138326,
-0.024388187,
-0.011791305,
0.02293295,
-0.01924289,
-0.040408768,
-0.011784809,
0.038251903,
-0.016917111,
-0.011856271,
-0.0031151134,
-0.012064162,
-0.010284097,
-0.0075815166,
0.028013282,
0.004430672,
-0.0067954296,
-0.015812691,
0.02002248,
0.030559944,
-0.0055415886,
0.00078446284,
0.03328851,
0.013577866,
-0.0034301977,
0.016046569,
-0.0010776214,
0.006334172,
-0.01932085,
0.004252016,
0.032171097,
0.007074783,
0.0032694072,
0.009251139,
0.022374244,
0.0067954296,
0.005934632,
0.02460907,
-0.012882732,
-0.006512828,
0.0034626806,
-0.02944253,
-0.034172047,
-0.0064153792,
0.0025076824,
0.0100502195,
-0.0040896013,
0.012720317,
-0.006389393,
-0.005989853,
0.020542206,
-0.015877659,
0.015747726,
-0.0013309882,
0.0032141863,
0.002413482,
0.021971457,
0.03926537,
0.015279972,
0.023764513,
0.0017199713,
0.027311651,
-0.013447935,
0.033834223,
0.0030923754,
0.016033577,
-0.009127704,
-0.0043559615,
-0.01054396,
-0.020802071,
-0.023439685,
0.015942624,
0.01887908,
-0.00038268956,
0.06875987,
0.003608854,
-0.020048467,
-0.0029754366,
-0.00392069,
0.03419803,
0.0093031125,
0.03279477,
-0.027545528,
-0.0017508301,
0.024816962,
-0.003664075,
0.038018025,
-0.021009961,
-0.008646957,
0.016072556,
-0.006421876,
0.0070552933,
-0.013980655,
-0.00540516,
0.03747231,
-0.006168509,
-0.0108817825,
0.006256213,
-0.024167303,
-0.014721265,
0.047061276,
-0.007730938,
0.022023428,
-0.03640687,
-0.000608649,
-0.0055285953,
-0.01735888,
0.021191865,
-0.003641337,
-0.022854991,
-0.020373296,
-0.03380824,
0.033340484,
0.042357747,
-0.023244787,
0.019437788,
-0.0006801114,
-0.008984779,
-0.0030176644,
-0.016579289,
-0.0017086023,
-0.010368552,
-0.009290119
] |
BACKGROUND Self-reported health status in underserved population of prisoners has not been extensively explored. The purposes of this cross-sectional study were to assess self-reported health, quality of life, and access to health services in a sample of male prisoners of Italy. METHODS A total of 908 prisoners received a self-administered anonymous questionnaire pertaining on demographic and detention characteristics, self-reported health status and quality of life, access to health services, lifestyles, and participation to preventive, social, and rehabilitation programs. A total of 650 prisoners agreed to participate in the study and returned the questionnaire. RESULTS Respectively, 31.6% and 43.
|
[
0.0139813805,
-0.015439155,
0.020607626,
-0.052135307,
-0.021389524,
0.011595932,
-0.0040188185,
0.01679091,
-0.03360832,
-0.016194547,
-0.0071695987,
0.015425902,
-0.013848855,
0.006483782,
0.008892423,
-0.0071099624,
0.043918762,
-0.030904815,
-0.010939933,
-0.008680383,
-0.0040155053,
0.015386145,
-0.022847299,
0.010920054,
0.0006609681,
0.006944306,
0.0037405163,
-0.022966571,
0.01339827,
-0.020952191,
-0.0034854056,
-0.003377729,
-0.03464202,
-0.011701952,
-0.026836298,
0.011483286,
-0.0047675846,
-0.017480038,
0.007938243,
-0.011450154,
0.016459597,
-0.005377199,
0.010562237,
0.006404267,
0.005784713,
0.007898486,
0.0036775668,
0.0012101183,
-0.01998476,
0.015810225,
0.0056786933,
0.01924262,
-0.02918199,
0.010509227,
0.0170162,
-0.005718451,
0.007037074,
0.005778087,
-0.015757214,
-0.0007918365,
0.0009276745,
-0.0013625219,
-0.04267303,
0.012868171,
-0.03151443,
0.0039790613,
-0.0090713315,
-0.0053142495,
0.035861246,
0.0052910578,
0.03485406,
0.01712222,
-0.009170725,
-0.00567538,
0.028095286,
0.00736176,
-0.0156777,
0.0010759368,
-0.0023821357,
0.009786966,
0.0049001095,
-0.030083159,
-0.01903058,
0.018208925,
0.0055163503,
0.016154788,
-0.008865918,
0.030295199,
0.025590565,
-0.0033760727,
-0.015147599,
-0.003498658,
0.016552364,
0.0147367725,
-0.0024500547,
0.01203989,
-0.011556174,
-0.000873008,
-0.009667694,
-0.024583375,
-0.01198688,
0.016088527,
-0.022582248,
-0.02238346,
-0.013597058,
-0.012450717,
-0.024305072,
-0.029314514,
0.004270616,
0.00082165457,
-0.023311136,
0.0150415795,
-0.0017957129,
-0.033449292,
0.01345128,
0.00039177682,
-0.00789186,
-0.025842361,
0.002335752,
-0.016565617,
0.0075737997,
-0.009455654,
0.031249378,
-0.016009012,
0.010071895,
0.016353577,
-0.019679952,
0.016260808,
0.0021584998,
0.0017957129,
-0.024742404,
-0.0028327205,
0.039624956,
0.010701388,
-0.0012142597,
-0.016605373,
-0.005238048,
0.00088708877,
-0.01993175,
-0.022794288,
0.008408707,
0.020395586,
0.010290561,
-0.011754962,
-0.00205248,
0.0049597453,
0.037451547,
-0.0059238644,
-0.0324156,
0.0062783686,
0.0057317032,
-0.007063579,
0.0019928436,
0.015121095,
0.00542027,
0.021005202,
-0.011821223,
0.03493357,
-0.02201239,
-0.021919623,
-0.0074545275,
0.005135341,
-0.017983634,
0.0009400987,
-0.016843919,
0.03024219,
0.019520922,
-0.0068382863,
-0.003140841,
0.0044263327,
-0.001061856,
0.025855614,
-0.011026074,
0.015227115,
0.01235795,
0.008733393,
-0.010867044,
0.0052082296,
-0.020501606,
-0.008070768,
-0.033502303,
0.05497134,
0.023417156,
0.024265315,
-0.017652322,
-0.011801345,
0.013206109,
0.0061127124,
0.00059553393,
-0.008965312,
-0.0030580128,
0.0068647913,
-0.0061392174,
-0.0043302523,
-0.6505384,
-0.021429282,
0.0024881556,
-0.0015265215,
0.008097273,
0.01956068,
0.019481165,
0.026703773,
-0.015372892,
0.034164928,
0.015651194,
0.020276314,
-0.00016420668,
-0.039041843,
-0.014577743,
-0.015757214,
-0.0020905808,
0.014060895,
0.018208925,
-0.012914554,
-0.02812179,
0.0059106117,
-0.00049738266,
0.01641984,
-0.0021336514,
0.020236557,
0.010953185,
-0.019693205,
-0.011529669,
0.033290263,
-0.005933804,
0.008620746,
0.017453533,
0.036179308,
0.040155053,
-0.037875626,
-0.0055991784,
0.021336515,
0.009217109,
0.040526126,
-0.0115628,
0.00024993374,
0.016075274,
0.0010303813,
0.0025361958,
-0.0032369215,
0.0072358614,
0.019176358,
0.017851109,
0.009535169,
0.021310009,
0.0011794718,
-0.027247125,
-0.002040884,
0.021137727,
-0.0027664579,
0.012563364,
-0.011516416,
0.022078654,
-0.005609118,
-0.0068714176,
0.0128482925,
-0.0007495941,
-0.016115032,
-0.0005197462,
0.037239507,
0.005933804,
0.012364576,
-0.00042263028,
-0.0040453235,
-0.0000032306189,
0.022966571,
-0.015253619,
0.000016280896,
0.034164928,
0.008846039,
0.0027830235,
0.004108273,
-0.036073286,
-0.0073286286,
0.0012407646,
0.0072358614,
0.0072159823,
0.014803035,
0.006132591,
-0.0006116854,
-0.026743531,
0.020276314,
-0.010867044,
0.02667727,
0.018725773,
-0.011059205,
0.016658384,
-0.0016805818,
-0.0145379845,
0.013126594,
-0.01278203,
-0.021389524,
0.029367525,
-0.021084717,
-0.021243747,
-0.010939933,
0.016552364,
0.031540934,
-0.0002869993,
0.018208925,
-0.023642447,
0.008574363,
0.045058478,
-0.023112347,
0.020528112,
0.03387337,
0.00951529,
0.0017824604,
0.016830666,
-0.025153233,
0.044130802,
0.011708578,
-0.011648942,
-0.02339065,
0.006241924,
0.021469038,
0.03922738,
-0.0053341286,
0.02381473,
0.036550377,
0.0015480568,
-0.0063877017,
-0.016936686,
-0.007421396,
0.0027714276,
0.023589438,
0.02189312,
-0.005337442,
0.00709671,
-0.011728456,
-0.0049233013,
-0.0078123445,
0.002595832,
-0.008342444,
-0.0064804694,
-0.016393334,
0.006510287,
0.002430176,
-0.010721267,
-0.030798795,
-0.0029304575,
-0.007984627,
0.008965312,
-0.012331445,
0.0050425734,
-0.034827553,
-0.030083159,
0.0039890003,
-0.00946228,
-0.017360765,
0.0059205513,
-0.019375145,
0.018116158,
-0.008229799,
0.00789186,
0.032124043,
-0.02609416,
-0.010674884,
0.02088593,
-0.025179736,
0.010171289,
0.03283968,
0.008276182,
-0.045376536,
0.017652322,
-0.010761024,
-0.0045754234,
0.009767087,
-0.019865487,
-0.00018812327,
-0.008070768,
0.0052778055,
0.010555611,
-0.018633006,
0.009502037,
0.0006845741,
-0.021429282,
-0.020978697,
0.013285625,
-0.0032170427,
0.04985588,
0.04177186,
-0.008985191,
0.008368949,
-0.0039890003,
0.009362887,
0.00494318,
0.018739026,
-0.016843919,
0.023827983,
-0.00231256,
0.025577312,
0.006265116,
0.0029072657,
0.026849551,
0.015624689,
0.026942318,
-0.028943446,
0.011622436,
-0.011867608,
0.0071629724,
0.010688135,
0.008846039,
-0.0034754663,
0.024941193,
-0.02769771,
-0.013497665,
-0.010542358,
-0.02854587,
0.01467051,
-0.015584932,
0.0036775668,
-0.015107842,
-0.0008779777,
0.0014345824,
-0.0047609583,
0.0047212006,
-0.0001344921,
-0.0015902992,
0.00661962,
-0.0035947387,
0.026955571,
0.009475533,
0.0010966439,
-0.006666004,
0.015227115,
0.014842792,
0.0050193816,
0.022052148,
0.018513734,
0.01084054,
-0.013060332,
0.00026401452,
0.008938807,
0.0013641785,
0.02727363,
0.009634563,
-0.0008117152,
0.0020922374,
-0.034191433,
0.043706723,
0.0014710267,
-0.016035516,
0.01987874,
0.0058410363,
0.016631879,
-0.013795845,
0.003087831,
-0.008408707,
-0.0076930723,
-0.004085081,
-0.006178975,
0.020660637,
0.0022164795,
0.035490178,
0.02169433,
0.0127223935,
-0.011940496,
0.008064142,
-0.0033214062,
-0.018116158,
-0.016048769,
0.0140874,
0.0013020574,
-0.01631382,
-0.010409833,
0.028943446,
-0.011542922,
0.0053440677,
0.012172415,
-0.006646125,
-0.012119405,
0.04715237,
0.0037703342,
-0.037398536,
-0.0065732365,
0.023085844,
0.00940927,
0.02009078,
-0.026385713,
-0.0017360765,
0.030295199,
-0.028784415,
0.008150283,
0.0019116722,
0.013106716,
0.0015911275,
-0.010807408,
0.00494318,
-0.0039525563,
0.0015969254,
-0.023735216,
0.017175231,
-0.006175662,
0.0095683,
-0.0063711363,
-0.026876057,
-0.00097322994,
0.035092603,
0.007500911,
-0.015372892,
-0.022303946,
-0.012523606,
-0.009495411,
0.0068184077,
0.013265746,
-0.0078852335,
0.01299407,
0.0025825796,
0.0014776529,
-0.020263063,
-0.002781367,
0.022675015,
-0.0035847994,
-0.012894676,
-0.034111917,
-0.024596628,
-0.011251367,
0.081529334,
0.023059338,
0.020011265,
0.010694762,
0.017784845,
-0.013192857,
0.00656661,
-0.012404334,
-0.007606931,
-0.008905675,
0.0021319948,
-0.015346387,
0.0021982573,
0.008991817,
0.030427724,
0.006096147,
-0.0028509425,
-0.01419342,
0.0058708545,
-0.0024136102,
0.0029337707,
-0.00925024,
0.00935626,
0.050518505,
0.027856741,
-0.005754895,
0.02950005,
0.0076930723,
0.014312693,
-0.0030182553,
0.0018172481,
0.022542492,
-0.011410397,
0.0014909055,
-0.05202929,
0.016446345,
0.023536427,
0.00599344,
0.009455654,
0.016645132,
0.024066528,
0.015664447,
0.004078455,
0.0005006958,
0.017453533,
-0.012132658,
0.008905675,
0.022900308,
0.012874797,
-0.0018056522,
0.031673457,
-0.011377266,
-0.0023374085,
-0.03662989,
-0.0049597453,
0.014339197,
0.017281251,
-0.0053871386,
-0.011277871,
-0.004648312,
-0.020488353,
-0.006079581,
0.0074545275,
-0.0063545704,
-0.042779047,
-0.016287314,
-0.016936686,
-0.0034489613,
-0.0049531194,
0.0026803168,
0.0515522,
-0.01691018,
-0.0001598582,
0.02944704,
0.017970381,
0.0030513864,
-0.010621874,
-0.0002105904,
0.01403439,
0.027326642,
-0.014047643,
-0.016274061,
0.0043401914,
-0.009846603,
-0.013000696,
0.016578868,
-0.024225557,
-0.03975748,
-0.008991817,
0.016260808,
-0.016724646,
0.0068184077,
-0.017692078,
-0.002146904,
-0.012371202,
0.0053440677,
0.02088593,
0.0071033365,
-0.02386774,
-0.0068979226,
0.015253619,
-0.03024219,
-0.01166882,
-0.025020707,
0.00483716,
-0.0051452806,
-0.02780373,
0.0072954977,
-0.0063843885,
-0.03246861,
0.020965444,
-0.030639764,
-0.008978564,
0.005890733,
0.0046085543,
-0.015651194,
-0.012265182,
0.0067587714,
0.022224432,
0.006182288,
-0.01680416,
-0.0010394924,
0.032362588,
0.016499354,
-0.025974886,
0.014166915,
-0.023430407,
-0.01403439,
-0.03177948,
-0.015465659,
-0.010615247,
0.021058211,
-0.0068647913,
-0.050730545,
-0.0038332837,
-0.018010138,
-0.030401219,
0.015386145,
-0.00021514595,
-0.013166352,
-0.031037338,
-0.0005408674,
-0.026624259,
-0.015730709,
0.031381905,
-0.0257761,
-0.0075605474,
-0.0008402909,
-0.028678395,
0.0002067596,
-0.014259683,
0.0019365206,
-0.0028525991,
0.009654441,
-0.012483848,
-0.048186064,
-0.005499785,
-0.00010581288,
0.04815956,
0.023642447,
0.011357387,
0.0047477055,
0.010230925,
0.014206673,
-0.010184541,
-0.0055726734,
-0.0095219165,
0.0062750555,
-0.0038233444,
0.023178611,
0.0077725872,
0.014657257,
-0.018792035,
-0.00336282,
0.006228672,
0.03220356,
-0.015651194,
-0.013378392,
-0.020329325,
-0.016393334,
0.0036775668,
0.0031242752,
-0.025696585,
-0.011224861,
-0.03424444,
-0.015213862,
0.0028923566,
-0.014074148,
-0.008554485,
-0.032574628,
-0.012338071,
-0.014259683,
0.015306629,
-0.015505417,
-0.007017195,
-0.0022280754,
0.0050723916,
-0.018686015,
0.008918928,
0.027127853,
0.001958056,
0.010423086,
-0.004598615,
-0.021310009,
-0.0069774375,
0.0150415795,
-0.024901435,
-0.009661067,
0.003783587,
-0.017334262,
0.0052744923,
-0.002017692,
-0.011821223,
-0.012126031,
-0.011383892,
0.005592552,
-0.0029155484,
0.012265182,
-0.0068449127,
-0.01283504,
-0.0016698141,
-0.0134777855,
-0.0048239073,
-0.009813471,
0.013597058,
0.02238346,
-0.02003777,
-0.0086406255,
0.004621807,
0.025471292,
-0.012265182,
0.025020707,
0.011443527,
-0.007017195,
-0.027750721,
0.0029105789,
0.0060365107,
-0.014272935,
-0.044183813,
0.026703773,
0.03034821,
-0.0003424941,
-0.024941193,
0.013126594,
-0.04964384,
-0.0076731937,
-0.008912302,
-0.010721267,
0.006175662,
-0.005811218,
-0.013756088,
0.04044661,
-0.027406156,
-0.0012200576,
0.00741477,
-0.008037637,
0.012556737,
-0.023934003,
-0.011178478,
-0.0010568863,
0.0021667827,
0.022290694,
-0.00547328,
0.009813471,
0.010078521,
-0.004538979,
0.007858728,
0.016300566,
-0.012391081,
0.030533744,
-0.028731406,
-0.022635259,
0.024040023,
-0.013219362,
-0.009912865,
0.024305072,
-0.005562734,
-0.0023009642,
-0.02280754,
-0.0021634696,
0.012656131,
0.019587185,
-0.022197926,
-0.021720836,
-0.0095219165,
-0.013650068,
-0.02769771,
-0.02323162,
0.010383328,
-0.0072424873,
-0.018261936,
-0.020276314,
0.016433092,
0.02626644,
-0.005778087,
0.013126594,
-0.016631879,
0.012801908,
-0.036126297,
0.021442534,
0.015624689,
-0.0025063779,
-0.02397376,
0.005456714,
-0.015054832,
-0.025723089,
0.012026638,
0.0015902992,
-0.018222177,
-0.021150978,
0.002203227,
0.024093032,
0.0044760294,
-0.0008738363,
0.012682636,
0.010827287,
0.0021170857,
-0.013809098,
-0.015121095,
0.035251632,
-0.008932181,
0.0063446313,
0.018619753,
-0.03056025,
0.015174105,
-0.009011695,
0.03379386,
0.023695458,
-0.022025643,
-0.008415333,
-0.03535765,
0.015757214,
-0.017877614,
-0.0015116124,
-0.013623563,
0.012364576,
-0.021575058,
0.04336216,
-0.0097008245,
-0.017055959,
0.008057516,
-0.0060597025,
0.014100653,
-0.00068995793,
0.00029548918,
-0.011794719,
0.0028161549,
-0.009608057,
-0.008547858,
-0.012609747,
-0.008143657,
0.02397376,
0.031275883,
-0.013835602,
-0.02838684,
-0.0050624525,
-0.05245337,
-0.0013177948,
-0.0011281185,
0.02849286,
0.011098963,
0.015266872,
-0.009402644,
0.02838684,
0.018248683,
0.0055859257,
-0.026200179,
-0.04129477,
0.027883245,
-0.02003777,
0.02344366,
-0.016009012,
-0.03207103,
-0.013060332,
0.008143657,
0.008832786,
-0.0063015604,
0.013212736,
0.0002843074,
-0.00636451,
-0.0046085543,
0.019573933,
0.019732961,
-0.0013343605,
0.00053755427,
-0.018063148,
-0.000775685,
-0.0007968061,
0.019229367,
0.008667131,
0.019269126,
0.006450651,
0.013716331,
-0.025232747,
0.0009044827,
-0.0313554,
0.019587185,
-0.011629063,
0.0140874,
0.026982076,
-0.0048967963,
0.0017145413,
-0.022264188,
0.0030397906,
-0.0152403675,
0.018911308,
-0.0035052844,
-0.012921181,
0.0119670015,
-0.015333135,
-0.007984627,
-0.01802339,
-0.016671637,
0.012881423,
0.010058642,
-0.02647848,
-0.031090349,
-0.012914554,
0.017904118,
0.005996753,
-0.011947122,
-0.008441838,
-0.0038929197,
-0.003038134,
-0.0034191431,
-0.014869297,
-0.011741709,
-0.0162078,
0.013484412,
-0.009488785,
0.007633436,
0.023377398,
0.0066030547,
-0.0071099624,
-0.0074280226,
0.018805288,
0.19751516,
-0.00667263,
-0.0059006726,
0.015054832,
0.0008754928,
0.019679952,
0.03811417,
0.0016217738,
0.0010105026,
0.046118677,
0.018222177,
-0.01749329,
0.0009914521,
0.009111089,
0.015399397,
-0.023483418,
-0.0075406684,
-0.008117152,
0.0040685153,
0.0072358614,
-0.036576882,
-0.008620746,
-0.0007164629,
-0.0061922274,
0.02854587,
0.019017328,
-0.01251698,
-0.00993937,
0.040976707,
0.015386145,
0.015730709,
-0.009422523,
0.010171289,
-0.026637511,
-0.017798098,
-0.0036146175,
0.0071695987,
-0.004267303,
-0.0005052513,
-0.020978697,
-0.0043401914,
-0.013086837,
-0.0075472947,
-0.012861544,
0.011483286,
0.014166915,
0.009574926,
0.011032701,
-0.013471159,
-0.001456946,
-0.033237252,
0.0023224994,
0.0324156,
0.017334262,
-0.02460988,
0.00736176,
0.013510916,
-0.0076268096,
-0.018314945,
-0.011854355,
0.034138422,
-0.0010287248,
-0.023801478,
0.018898055,
-0.023191864,
0.028201306,
-0.00967432,
-0.008203293,
-0.026041148,
-0.005556108,
0.0071961037,
-0.0035914257,
-0.0147367725,
0.0024517113,
-0.00820992,
-0.012510354,
0.04134778,
0.031090349,
0.0064407117,
0.007090084,
0.014392207,
-0.017837856,
-0.013742835,
0.009528543,
-0.033899877,
-0.0287049,
0.008229799,
0.011065831,
-0.032177053,
-0.017851109,
-0.0018255309,
-0.0073153763,
-0.008534606,
-0.012967564,
-0.0001793228,
0.009608057,
0.012106152,
0.012046516,
-0.0067488323,
-0.037981644,
-0.01850048,
0.06414206,
-0.012497101,
0.0126495045,
-0.005294371,
-0.016989697,
-0.01881854,
0.024000265,
0.006659378,
-0.01722824,
0.0067024482,
-0.02637246,
0.00018801975,
-0.020978697,
0.036391348,
0.0058708545,
-0.005556108,
-0.029791605,
0.037027467,
-0.022582248,
0.013809098,
-0.025020707,
0.013689825,
0.015876487,
-0.022728026,
-0.0150415795,
-0.022820793,
-0.011927244,
0.015412649,
-0.01839446,
-0.004578736,
-0.030798795,
0.0034025777,
-0.008852665,
0.0028128417,
0.00709671,
-0.019640194,
0.008435212,
-0.0072226087,
-0.0012631282,
0.010674884,
-0.025259253,
-0.0067488323,
-0.009707451,
0.016512606,
-0.025418282,
0.007282245,
0.012927807,
0.013298877,
-0.005837723,
-0.011364013,
-0.013285625,
-0.0029470231,
-0.01084054,
0.044793427,
-0.012086274,
-0.02376172,
-0.024861677,
-0.008368949,
0.006178975,
-0.005148594,
0.004326939,
0.016287314,
-0.0068979226,
0.00012848707,
0.039890002,
-0.16772355,
0.035516683,
0.00925024,
-0.03246861,
0.02934102,
-0.010661631,
0.0133518865,
0.0048172814,
-0.01477653,
-0.013742835,
0.015836729,
0.0030315078,
-0.02148229,
-0.01140377,
0.014604247,
-0.000766988,
-0.0077725872,
0.0065069743,
0.028042275,
0.01892456,
0.025113475,
0.008494848,
-0.0018371269,
0.010462843,
0.012086274,
-0.023403903,
-0.010807408,
0.009309877,
-0.011132094,
-0.0236557,
0.01498857,
0.017374018,
0.0132259885,
-0.00039571116,
-0.022065401,
0.011224861,
-0.0018354703,
0.0065732365,
0.002244641,
0.0040188185,
0.033899877,
0.02748567,
-0.0040883943,
0.011741709,
0.0022860551,
0.03225657,
0.01722824,
-0.02971209,
0.0036775668,
-0.004121525,
-0.0162078,
-0.013066959,
0.02035583,
0.0020773283,
0.018301694,
0.015359639,
-0.009760461,
0.008223172,
0.021641321,
0.0031988206,
-0.030003645,
-0.0038465362,
0.015359639,
0.003061326,
0.0032799921,
-0.017851109,
-0.025471292,
-0.0030778914,
-0.002501408,
0.015439155,
-0.032495115,
0.0028592255,
0.0023904184,
0.009336381,
0.035463672,
0.016393334,
-0.0076996987,
-0.014763277,
0.007593679,
-0.011675446,
0.0013467846,
-0.0054235826,
-0.01850048,
-0.018208925,
-0.00024330748,
0.015266872,
-0.0027068218,
-0.0063015604,
-0.0056058047,
-0.016830666,
0.015929496,
-0.03289269,
0.007964748,
-0.01897757,
0.00094506843,
0.023032833,
0.013650068,
-0.0150415795,
0.0034522745,
-0.030957824,
0.013053706,
-0.0048272205,
-0.016433092,
0.0009376139,
-0.006781963,
-0.02127025,
-0.024954444,
-0.006781963,
0.020183546,
-0.011118841,
-0.02397376,
0.010423086,
-0.013901865,
-0.0028128417,
0.008667131,
0.037451547,
0.0018106218,
-0.014577743,
0.0023042771,
-0.021429282,
0.042699534,
-0.011112216,
-0.0040685153,
0.0124705965,
0.012642878,
0.013040453,
-0.12573965,
0.021985887,
0.016221052,
0.031063844,
0.030613258,
0.031222874,
0.0077858395,
0.02833383,
-0.027127853,
0.016552364,
-0.0038200312,
-0.012748898,
-0.0019365206,
-0.016989697,
0.04450187,
-0.006712388,
-0.00794487,
-0.022529239,
0.0055991784,
0.025418282,
-0.00160438,
-0.016035516,
0.008117152,
-0.017745089,
0.006215419,
0.00046549382,
-0.025524301,
0.018155916,
0.0115362955,
0.008362323,
-0.008998442,
0.011940496,
0.0035284762,
-0.015174105,
-0.011443527,
0.0030016897,
0.004273929,
-0.016393334,
0.030056654,
-0.029208494,
0.0056853197,
0.006185601,
0.022356955,
-0.016936686,
0.018911308,
-0.008342444,
0.0021999138,
-0.022224432,
0.02487493,
-0.008017758,
-0.031461418,
0.009329755,
-0.013391645,
-0.02024981,
0.0007930789,
-0.026001392,
0.010615247,
-0.015213862,
-0.0037802737,
0.0036146175,
-0.012139284,
0.014431965,
-0.0014312692,
0.025815856,
0.0186065,
-0.008017758,
-0.025511049,
-0.004406454,
0.003167346,
-0.015001822,
-0.010807408,
0.011383892,
0.0014229865,
-0.012523606,
-0.01435245,
-0.01759931,
-0.006013319,
-0.010290561,
-0.0020574497,
-0.0007218467,
-0.008090647,
-0.0019216115,
0.021747341,
-0.03442998,
0.0000958735,
-0.013809098,
0.01135076,
-0.009839976,
0.0060862075,
0.0009583209,
-0.009422523,
0.027538681,
0.00405195,
-0.025723089,
0.020501606,
0.008918928,
-0.004138091,
0.0023738528,
-0.012159162,
-0.020541364,
-0.025259253,
-0.02158831,
-0.05831097,
0.006079581,
0.012503727,
-0.035225127,
-0.013285625,
0.008958685,
0.01294106,
-0.005297684,
-0.0010071895,
0.009634563,
-0.020011265,
0.020634132,
-0.011112216,
-0.017440282,
-0.03077229,
0.0072954977,
0.03268065,
0.015200609,
0.031965014,
0.039677963,
0.005513037,
-0.009528543,
0.019110095,
-0.007984627,
-0.009376138,
0.010184541,
0.0035616076,
0.035384156,
-0.023178611,
-0.015253619,
-0.0027084784,
-0.005718451,
-0.011609184,
0.0081900405,
-0.022436472,
-0.019282378,
0.031673457,
0.01987874,
0.012980817,
0.023880992,
-0.014750025,
-0.018540237,
0.017692078,
-0.01770533,
-0.0073418813,
0.022555742,
-0.018314945,
0.026968824,
-0.0038200312,
-0.0062750555,
0.025895372,
0.0049498063,
-0.011410397,
-0.012682636,
-0.006500348,
-0.0037504556,
-0.020620879,
0.03225657,
-0.0044462113,
-0.023576185,
0.030162673,
0.011794719,
0.005698572,
-0.008514727,
0.0018520359,
-0.0217871,
-0.006159096,
-0.003919425,
0.0021551866,
-0.008329192,
-0.020819666,
-0.018288441,
0.0035384158,
0.008687009,
0.006175662,
0.009263493,
0.0011231488,
0.016578868,
-0.010847165,
0.030745784,
0.02067389,
0.0015091277,
-0.024570122,
0.035119105,
0.040473115,
0.015174105,
-0.025709836,
0.03647086,
-0.00035616074,
-0.0027250438,
-0.004886857,
0.020514859,
0.014948812,
0.020077527,
0.0001817041,
0.02397376,
-0.00037210516,
-0.012172415,
0.018434217,
0.012563364,
0.006878044,
0.010926681,
-0.0036775668,
-0.058151938,
-0.013862108,
-0.011741709,
-0.013338635,
-0.04762946,
-0.020766657,
0.016154788,
0.031487923,
0.00820992,
-0.037769604,
0.00052927143,
-0.031063844,
0.003985687,
-0.0065732365,
0.010118279,
-0.0068117813,
0.01445847,
-0.0137825925,
0.029314514,
0.013153099,
-0.01881854,
0.0057615214,
0.004138091,
0.006182288,
-0.004270616,
-0.015929496,
-0.023827983,
0.011688699,
-0.00012776232,
-0.023377398,
0.0018801974,
-0.004085081,
-0.016287314,
0.001987874,
0.009236988,
-0.011569426,
0.05523639,
0.018155916,
-0.01110559,
-0.005373886,
0.003268396,
0.008501475,
-0.00028389326,
0.0115362955,
-0.004618494,
-0.021389524,
0.023854489,
-0.021840109,
0.016221052,
-0.03694795,
-0.008110526,
-0.0029884372,
-0.011450154,
0.015333135,
-0.0058443495,
-0.019322135,
0.013206109,
-0.023032833,
0.0076996987,
-0.00024662062,
-0.01881854,
-0.0014768247,
0.018155916,
-0.015823476,
-0.008899049,
-0.015969254,
0.016340325,
0.00005352765,
-0.03183249,
-0.011576053,
0.03917437,
-0.0064937216,
-0.0038631018,
-0.009581553,
0.0033760727,
-0.005771461,
-0.004121525,
0.03140841,
-0.018036643,
0.014869297,
-0.019043833,
-0.047284894,
0.0045058476,
0.0034787795,
0.0000063771154
] |
Hypoxia is a common cause of cell death and is implicated in many disease processes including stroke and chronic degenerative disorders. In response to hypoxia, cells express a variety of genes, which allow adaptation to altered metabolic demands, decreased oxygen demands, and the removal of irreversibly damaged cells. Using polymerase chain reaction–based suppression subtractive hybridization to find genes that are differentially expressed in hypoxia, we identified the BH3-only Bcl-2 family protein Noxa. Noxa is a candidate molecule mediating p53-induced apoptosis. We show that Noxa promoter responds directly to hypoxia via
|
[
-0.01931079,
-0.009708265,
-0.004345258,
-0.033572488,
-0.033281703,
0.017513208,
-0.014565702,
0.019191831,
-0.01989236,
0.0011474455,
-0.0024022833,
-0.0034365538,
0.025721284,
0.01872922,
-0.010441837,
-0.0023312392,
0.03180134,
0.000120816345,
0.007758681,
0.0063576247,
-0.01728851,
0.039335325,
0.000085345906,
0.0067805853,
-0.0022106294,
0.014975444,
0.0023940224,
-0.03653321,
-0.00024824144,
-0.03621599,
0.021518115,
0.002260195,
-0.013693346,
-0.009556264,
0.0030482893,
-0.0015712321,
-0.016905202,
-0.007031718,
0.014724311,
-0.0020536713,
-0.0006947456,
0.013785868,
0.0067805853,
0.009853657,
-0.010336096,
-0.016310412,
-0.0043419534,
-0.024148399,
0.01393126,
0.004940046,
0.019641226,
0.013534735,
-0.007824769,
-0.0074480698,
0.011287758,
-0.012060982,
0.014208828,
0.0065492787,
0.003952037,
0.0076198974,
-0.004222996,
-0.008056075,
-0.02340822,
0.0073357206,
-0.0021841943,
0.0004878089,
0.013785868,
0.02638216,
0.013587605,
-0.017936168,
0.047239397,
0.027571736,
-0.0023312392,
0.0003506772,
0.0065129306,
-0.028285481,
-0.029210707,
-0.0053035277,
-0.00867069,
0.0023708916,
0.018689565,
-0.021993944,
-0.0008930084,
0.033149526,
0.039388195,
-0.014023784,
-0.038145747,
0.015147272,
0.004659174,
0.0009855309,
0.037088346,
0.019456182,
0.017486772,
0.009001127,
-0.011320801,
0.019442964,
-0.0004031342,
0.026183898,
-0.0061891014,
-0.02696373,
-0.005049091,
0.0016744939,
-0.025774155,
-0.0070449356,
-0.0405249,
-0.0020900196,
0.0030235066,
0.004702131,
0.0019842794,
0.014922574,
-0.028999228,
0.028047567,
-0.012675596,
-0.04623487,
0.029237144,
-0.0104880985,
0.027703911,
0.008954866,
-0.030664634,
-0.019509053,
0.014843269,
0.015543797,
0.007388591,
-0.034233365,
0.0031722037,
-0.0016199717,
-0.025126496,
-0.0058090976,
-0.0006910282,
-0.009384436,
0.0041899523,
0.02340822,
-0.00396195,
-0.019746967,
-0.01973375,
0.014856487,
-0.015411622,
-0.03711478,
-0.010858188,
-0.032382913,
0.013329864,
0.01925792,
-0.022218643,
-0.00095579156,
-0.011882545,
0.024756406,
0.007547201,
0.0015811452,
0.009562872,
0.0060767527,
-0.0037339479,
-0.012133678,
0.012510378,
-0.016905202,
0.0010020528,
0.014882922,
0.0065823225,
0.027518867,
-0.010329488,
-0.01728851,
0.0073621557,
-0.013415777,
-0.0063807555,
0.017090246,
-0.00059230987,
0.007705811,
-0.010045311,
0.0092126075,
-0.0010747492,
-0.01202133,
0.005521617,
0.008624429,
-0.042851184,
0.01925792,
0.01031627,
0.025523022,
0.019178614,
0.041688044,
0.009093651,
0.0005299397,
-0.0075075487,
0.01611215,
0.0068995426,
-0.006919369,
-0.037960704,
0.0112811485,
0.027703911,
-0.021095153,
0.024544924,
-0.010831754,
-0.016720157,
0.019165397,
-0.011234888,
0.00045435206,
-0.62894225,
-0.021901421,
-0.008003205,
-0.0032531607,
0.012041156,
0.021941075,
0.0130985575,
0.0006038752,
-0.014697877,
0.038595144,
-0.024663882,
0.01537197,
0.0007013544,
-0.026157461,
-0.0023378478,
-0.0322243,
-0.009100259,
-0.0060701435,
0.05249997,
-0.022482993,
-0.0033555967,
-0.020910108,
-0.026501117,
0.018967133,
-0.0067111934,
0.05101961,
0.027571736,
-0.025232235,
-0.00033725315,
0.03679756,
-0.0015918844,
0.012094026,
0.008743386,
-0.0069854567,
0.056941055,
-0.0015373622,
0.018570608,
0.025840241,
0.029104969,
0.008710342,
-0.01771147,
0.006978848,
0.031404816,
-0.0019066265,
0.001561319,
0.025787372,
0.016455807,
0.0071705016,
0.02165029,
-0.0056339656,
0.007388591,
0.0120543735,
-0.014023784,
0.019205049,
-0.009470349,
0.0025460238,
0.043432754,
-0.023897266,
0.023117434,
-0.007137458,
-0.00851208,
0.019231483,
-0.029422188,
-0.027545301,
-0.011895764,
0.033863273,
-0.023606481,
0.0068797166,
0.0064237122,
-0.012926729,
0.028734878,
0.014248481,
-0.002783939,
0.005227527,
0.0046294346,
0.03494711,
0.013382734,
0.040551335,
0.00016470262,
0.013561171,
0.0010532708,
-0.014116306,
-0.025430499,
-0.0012639249,
0.038145747,
-0.0016017975,
-0.02217899,
0.022998476,
0.006588931,
0.000846747,
0.007487722,
0.0012804468,
-0.035925206,
-0.023725439,
-0.019495834,
0.023685787,
-0.017248858,
0.0024121965,
0.019865924,
-0.02249621,
-0.007216763,
-0.0079371175,
-0.009833831,
-0.00048450453,
0.0037636873,
-0.0013944479,
-0.021253765,
-0.019178614,
0.032647263,
-0.018002255,
-0.013997348,
-0.008584776,
0.008247729,
-0.016746592,
-0.0027938522,
-0.012662379,
0.031457685,
0.008875561,
-0.011109321,
-0.050385166,
0.017262075,
-0.015398405,
-0.00867069,
-0.00888217,
0.033678226,
0.0055612694,
0.012292289,
-0.01324395,
-0.023223173,
-0.021399157,
0.008604602,
-0.0079239,
0.025945982,
-0.012642553,
0.0063311895,
-0.01393126,
0.01797582,
0.009780961,
0.02026245,
-0.0075009395,
-0.022416905,
0.0076463325,
-0.0073489384,
0.002808722,
-0.021570984,
0.006503017,
-0.026289636,
0.0022469775,
0.005557965,
0.015557015,
0.0041304734,
0.001082184,
-0.019390095,
0.019059656,
0.018636696,
-0.009034172,
-0.018517738,
-0.006846673,
-0.029712973,
-0.005617444,
0.009668612,
0.020011317,
-0.0013539692,
0.0073489384,
-0.02963367,
-0.021081936,
0.013442213,
0.025615543,
-0.0009442262,
-0.012417856,
-0.0015770147,
-0.026183898,
0.007355547,
-0.00034757933,
0.016984507,
0.007269633,
-0.020341756,
0.006440234,
-0.00898791,
-0.007104414,
0.018940698,
-0.032382913,
-0.018967133,
-0.004100734,
0.014129523,
0.015755277,
0.025827024,
0.010917667,
0.007441461,
0.026131026,
-0.016032845,
0.024743188,
-0.02562876,
0.018187301,
0.018094778,
-0.018319476,
0.014592136,
-0.0046657827,
0.01760573,
0.017632164,
0.020751499,
-0.015715625,
-0.0014564049,
-0.008161816,
0.03658608,
-0.010607055,
0.0032680305,
-0.0025427195,
-0.024148399,
0.0010887928,
-0.003104464,
0.008003205,
0.014446744,
-0.0066979756,
-0.0049433503,
0.0009962702,
-0.011942024,
0.008842518,
-0.0025344584,
-0.029078532,
0.013131601,
0.007190328,
0.011347236,
-0.009291913,
0.012589683,
-0.0033539443,
0.006945804,
0.017949386,
0.013812303,
0.007758681,
0.01175698,
0.008948257,
-0.0077785077,
-0.011836285,
-0.0006439408,
-0.0045864778,
0.0009120085,
-0.010197313,
0.023910485,
-0.0017942777,
-0.022152554,
0.0074480698,
0.0039189933,
-0.011353846,
-0.0036843822,
-0.012014721,
0.040974297,
-0.0218089,
-0.01568919,
0.006694671,
-0.0311669,
0.010878014,
-0.0031540294,
0.016283978,
-0.0016852331,
-0.023064563,
0.0037570787,
0.029580798,
0.051839095,
0.008763213,
0.026778685,
-0.012292289,
0.0041800393,
-0.0037802092,
-0.0032911613,
-0.009391044,
-0.0014464918,
0.0058950116,
-0.01069297,
-0.011611586,
-0.046076257,
-0.0034431627,
0.0015291013,
-0.023685787,
0.029131403,
-0.0055183126,
-0.006212232,
0.013316646,
0.031246206,
-0.006598844,
-0.008267555,
-0.025179366,
0.029924454,
0.032303605,
-0.021068718,
-0.016402936,
-0.05265858,
0.00446752,
-0.0033902926,
0.032515086,
0.011902372,
-0.009047389,
-0.013812303,
-0.001553058,
-0.004946655,
-0.0066616274,
0.013072122,
-0.01866313,
0.01627076,
-0.021795683,
0.0027575041,
-0.003829775,
-0.013957696,
0.013329864,
0.037934266,
0.0051878747,
0.019469399,
0.01175698,
-0.0021941075,
-0.02377831,
0.0028748096,
-0.014697877,
0.011254714,
-0.0066252793,
0.013395951,
-0.0046889135,
-0.006265102,
0.022575516,
0.00425604,
0.011148973,
-0.008234512,
-0.023461089,
-0.0002781874,
-0.013732998,
0.023791527,
0.027545301,
-0.032620825,
0.017671818,
-0.024016224,
0.028311918,
-0.0076925936,
0.004807871,
0.03195995,
-0.009820613,
-0.011439759,
0.00046715655,
-0.0039487327,
0.0035026413,
0.021293417,
0.025985634,
0.004976394,
-0.015755277,
-0.024016224,
0.009595916,
-0.012113852,
-0.015041532,
0.0074282433,
0.032620825,
0.012120461,
-0.004213083,
0.013772651,
0.029792279,
0.012477334,
0.0073357206,
-0.0070978054,
0.013587605,
0.009331565,
0.021518115,
-0.005306832,
-0.0053894417,
-0.005888403,
0.005534834,
0.017156335,
0.006939195,
0.0049962206,
0.010580621,
0.009794178,
0.009265478,
0.0018686262,
-0.021134807,
-0.01776434,
0.009027563,
-0.007824769,
-0.011175409,
0.015398405,
-0.036559645,
-0.03351962,
-0.016125368,
0.013772651,
-0.0158478,
-0.003707513,
0.0020718453,
0.011823067,
0.0131382095,
0.0010012267,
-0.018597044,
0.010996972,
-0.00957609,
-0.00011678914,
-0.0077190287,
0.009662003,
-0.008624429,
-0.028919922,
-0.01175037,
0.020870456,
-0.008108946,
-0.03410119,
0.017050594,
0.04597052,
0.028417656,
0.021557767,
-0.029660104,
0.004718653,
0.021015849,
-0.034339104,
-0.020804368,
0.00020012143,
-0.009556264,
0.017896514,
-0.008056075,
-0.0004493955,
-0.02759817,
-0.021095153,
0.003786818,
0.010388967,
-0.018345911,
0.0033093353,
0.006717802,
0.013785868,
0.015305882,
0.018147647,
0.03851584,
-0.009794178,
-0.009952788,
0.0064964085,
-0.03399545,
-0.03074394,
-0.01983949,
-0.0063477117,
-0.04641991,
0.016402936,
0.012801163,
0.003499337,
-0.011386889,
0.009642177,
0.015464492,
0.021716377,
-0.004137082,
0.0071837194,
0.011849502,
-0.005339876,
0.053689547,
-0.0176586,
0.018451652,
-0.010977146,
-0.010792101,
0.023434654,
0.009582698,
-0.01642937,
0.00022696951,
-0.00072572415,
-0.036956172,
-0.026395377,
0.004325432,
-0.009186173,
0.020077405,
0.015861018,
-0.022456558,
-0.03121977,
0.020275667,
0.0032845524,
-0.002443588,
-0.0040247333,
-0.02223186,
-0.0056504877,
-0.0040709944,
0.0014423613,
-0.025020756,
0.0337311,
-0.03489424,
-0.018848177,
0.008287381,
0.008492254,
-0.02728095,
-0.021029066,
-0.010864797,
-0.02664651,
-0.0008227903,
-0.01558345,
-0.037511308,
0.0010185747,
-0.0158478,
0.02632929,
0.023421437,
0.027465995,
0.016046062,
0.027307386,
0.02165029,
0.010706187,
-0.0015332317,
-0.0015034924,
0.00024183921,
-0.018808523,
0.027888956,
-0.020447496,
0.009093651,
0.004649261,
-0.010897841,
0.015226577,
0.02531154,
-0.018742437,
-0.03909741,
0.015239795,
-0.031457685,
-0.013957696,
0.005415877,
-0.021240547,
0.010296444,
-0.026527552,
0.0044443896,
0.034206927,
0.0012226201,
0.005392746,
-0.022245077,
0.0057397056,
0.00028933966,
0.00073605037,
0.002321326,
-0.004351867,
-0.00010935428,
-0.009979224,
0.032303605,
0.008201468,
-0.0011796632,
-0.005521617,
0.0067409324,
0.0038396881,
-0.023090998,
0.004170126,
0.017698253,
-0.025245454,
-0.02291917,
-0.010250183,
-0.019231483,
-0.016350066,
-0.01600641,
-0.0025608935,
-0.015794931,
-0.010811927,
0.029501494,
-0.023289261,
0.018623479,
-0.02010384,
-0.019218266,
0.020711847,
-0.018940698,
-0.0015357101,
-0.0035323808,
0.047450878,
-0.0016323631,
-0.024373097,
-0.00925226,
-0.009622351,
0.008617819,
-0.019628009,
0.03074394,
0.007950335,
-0.01802869,
-0.012860642,
-0.015662756,
0.01824017,
-0.01138028,
-0.0017463642,
0.022377253,
-0.012193157,
0.009073824,
0.017486772,
-0.013997348,
-0.018147647,
-0.0059809256,
-0.014499614,
0.0009343131,
-0.009060606,
-0.03772279,
0.006552583,
0.0102369655,
-0.00630145,
-0.0036513384,
0.0337311,
-0.011902372,
-0.00587849,
-0.0010417054,
-0.00059437513,
0.00130936,
-0.0223376,
0.031246206,
-0.01223281,
0.021663507,
0.011889155,
0.009503393,
0.013336472,
-0.0067078886,
-0.0020272364,
0.03679756,
-0.0051383087,
-0.006598844,
0.01494901,
-0.0038033398,
0.00670128,
-0.009331565,
-0.016455807,
-0.017618947,
-0.010745839,
0.003158986,
0.019971665,
0.0057264883,
-0.0024221097,
-0.0075604185,
-0.03962611,
-0.029686539,
-0.010111399,
-0.0332024,
-0.002486545,
-0.027888956,
0.013151428,
-0.013528126,
0.010937493,
0.0022387165,
0.0066979756,
-0.002584024,
-0.0077785077,
0.029290013,
-0.003281248,
0.00888217,
0.0105475765,
-0.00532005,
-0.019641226,
0.02276056,
-0.017037377,
-0.037141215,
0.014274916,
0.0009128346,
-0.02728095,
-0.009847049,
-0.00021292591,
0.018980352,
0.016244326,
-0.0102634,
0.032990918,
-0.0007310938,
0.002137933,
0.0016538416,
-0.013561171,
0.024478838,
-0.044595893,
0.040630642,
0.017777558,
-0.011875937,
-0.023024911,
-0.007223372,
-0.011902372,
-0.008954866,
-0.008260947,
-0.019218266,
-0.018160865,
0.00867069,
0.013276993,
-0.0094835665,
-0.022853084,
-0.008650864,
-0.024967885,
0.024240922,
0.023117434,
0.017460337,
-0.014155959,
0.016561545,
-0.01760573,
-0.008089119,
-0.016746592,
0.009549654,
-0.00097313954,
-0.032462217,
-0.032435782,
0.0075868536,
-0.009027563,
0.032885175,
0.014301351,
-0.013838738,
-0.010177487,
-0.009688439,
-0.031193335,
-0.002590633,
-0.010388967,
0.010858188,
-0.007732246,
0.016085716,
-0.017685035,
0.010018876,
0.01132741,
0.010402184,
0.0061296225,
-0.007401808,
0.009272086,
0.008432775,
0.017671818,
-0.010395575,
-0.009358001,
-0.006360929,
0.0337311,
-0.004315519,
-0.023725439,
0.022747343,
0.004616217,
0.0259592,
-0.014116306,
0.0038595144,
0.018332694,
0.008981301,
0.007031718,
-0.035343636,
-0.004259344,
0.016508676,
0.022707691,
-0.0056670094,
-0.00074678956,
0.014341003,
0.016495459,
-0.008181642,
-0.035555117,
-0.009853657,
0.006866499,
-0.0034596846,
0.010540968,
0.038277924,
0.010223748,
0.03994333,
0.0045071724,
-0.015173707,
-0.019760184,
-0.016297195,
-0.004536912,
-0.0068863253,
0.017090246,
-0.013475256,
-0.02611781,
-0.0034431627,
0.004682305,
-0.029792279,
-0.0028103741,
-0.027836086,
-0.0259592,
-0.02217899,
0.008214685,
0.0015084489,
-0.0034497713,
-0.010864797,
0.006255189,
-0.0069325864,
-0.022958823,
-0.005617444,
-0.015504145,
-0.019363659,
-0.0064964085,
-0.01101019,
0.015345534,
-0.009470349,
-0.0071837194,
-0.017275292,
-0.0046063038,
0.019363659,
0.18176727,
-0.012688815,
-0.0077983337,
0.01813443,
0.013587605,
-0.0014621876,
-0.011413324,
-0.01616502,
-0.0061791884,
0.0058817943,
0.013481865,
-0.0021247156,
-0.004318823,
-0.007844595,
0.012794554,
-0.010455054,
-0.026104592,
0.001265577,
-0.025708066,
-0.023606481,
-0.0041205604,
0.0049962206,
0.015517362,
-0.003515859,
0.043961454,
0.022060033,
-0.0205268,
-0.00007770453,
0.03537007,
-0.005462138,
-0.027545301,
0.016204674,
-0.0051614395,
-0.0070515443,
0.011571934,
0.023606481,
-0.0059313597,
-0.023527177,
-0.0067310194,
-0.011109321,
0.0023345435,
0.025827024,
-0.013865173,
0.025774155,
-0.005144918,
0.013105166,
0.006939195,
-0.0073225033,
-0.01808156,
-0.0022965432,
-0.049486376,
0.011367063,
-0.002607155,
0.041238647,
0.0015976671,
-0.004090821,
-0.008769821,
0.0143938735,
-0.012649162,
0.021729594,
-0.011023408,
0.013158036,
-0.014882922,
0.024214488,
-0.0036843822,
0.020434277,
-0.018478086,
-0.0011441411,
-0.00024225227,
-0.030426718,
0.005111874,
-0.014261698,
-0.01127454,
-0.0028863747,
-0.008274164,
-0.020473931,
0.027915392,
0.010838362,
0.0036282078,
0.0060370998,
0.018174082,
-0.006516235,
-0.024121964,
0.01813443,
-0.015517362,
-0.059214465,
0.008895388,
0.026818337,
-0.021306634,
-0.020275667,
0.028047567,
-0.016178237,
-0.013865173,
0.0138519555,
-0.006208928,
0.001693494,
-0.011439759,
0.025245454,
-0.027624605,
-0.012272462,
-0.03674469,
0.08009814,
-0.004351867,
0.017856862,
-0.0037537743,
0.012166723,
-0.007672767,
0.027545301,
-0.0067574545,
0.0047351746,
0.009133303,
-0.0038429925,
-0.012067591,
-0.012450899,
0.0022502819,
0.02580059,
0.0047516967,
-0.03111403,
0.018702783,
-0.022615168,
-0.004064386,
-0.021425592,
0.013012643,
0.02085724,
0.02026245,
0.006833455,
-0.024597796,
0.0068202377,
-0.0036843822,
-0.036982607,
0.020090623,
-0.0027641128,
-0.0022486297,
-0.0017265378,
0.016667286,
0.017248858,
0.013970913,
-0.009100259,
0.0013101861,
0.022734126,
-0.03700904,
0.002251934,
0.014023784,
0.018279823,
-0.006744237,
-0.024293792,
0.0126029,
-0.011479411,
0.0026484595,
0.013746215,
-0.031246206,
-0.021134807,
-0.00436178,
0.008465818,
0.025747718,
-0.016455807,
-0.0007356373,
-0.027307386,
0.024663882,
0.011895764,
-0.018861394,
0.016482241,
0.008730168,
-0.01329682,
0.0025493281,
0.00039838415,
-0.1652718,
0.00028397003,
0.011525673,
-0.024069095,
0.03164273,
0.0016323631,
0.009979224,
-0.004801262,
-0.0009830527,
-0.0058950116,
-0.0012226201,
-0.012873859,
-0.017090246,
-0.029369319,
0.0035455984,
-0.0065558874,
0.022839867,
0.038119312,
0.0102634,
0.00003064295,
0.0023609786,
0.018861394,
0.024558142,
-0.0026550684,
0.006787194,
0.0004588956,
0.0027541996,
0.0034629889,
-0.0041403864,
-0.0070911967,
-0.043194838,
-0.008327034,
-0.0133695165,
0.011922198,
-0.0008822691,
0.011036625,
0.008373296,
-0.0065691047,
-0.015279447,
0.031722035,
0.0031292466,
0.019760184,
-0.01824017,
-0.013812303,
-0.01760573,
0.03047959,
0.014631789,
0.0006179188,
0.011842893,
0.01494901,
0.010230357,
0.0015646233,
0.012450899,
0.02802113,
0.009913136,
-0.005776054,
0.007824769,
0.009747917,
-0.01952227,
0.010355923,
0.004269257,
-0.029475057,
0.018359128,
0.020328538,
0.00025195887,
-0.01802869,
-0.013732998,
0.013865173,
-0.03254152,
0.00532005,
-0.010289836,
-0.015662756,
0.022060033,
-0.0091729555,
0.014010565,
0.010911059,
-0.022509428,
0.0049003935,
-0.0026914165,
0.012483942,
0.004374997,
0.02042106,
-0.038700882,
-0.01973375,
0.003281248,
-0.0028120263,
0.004526999,
0.0076463325,
-0.015702408,
-0.011320801,
0.007104414,
-0.004589782,
-0.0069590216,
-0.001091271,
0.026236767,
0.024637448,
0.003813253,
-0.034206927,
0.0029243752,
0.015821366,
0.0064534517,
-0.012649162,
0.0010078355,
0.016720157,
0.045679733,
0.0013382734,
-0.0046029994,
0.0037702962,
0.0529758,
-0.017328162,
0.0011499238,
-0.0051977877,
0.0007224198,
0.029369319,
0.0073225033,
0.001797582,
0.007058153,
-0.019932013,
-0.016997725,
-0.019773401,
0.08607246,
0.017063811,
-0.009866875,
0.026818337,
-0.0010276617,
-0.039335325,
-0.12540779,
-0.019905576,
0.014050218,
0.005696749,
0.0019132353,
0.019918796,
-0.0005538965,
0.03967898,
-0.010970538,
0.03143125,
-0.016336849,
-0.009457132,
0.0070383265,
0.00061213615,
0.0311669,
-0.0033440313,
-0.0052737882,
0.0045005637,
0.0076992023,
0.036718257,
0.0056934445,
0.0032068996,
-0.009073824,
-0.0051085693,
-0.007461287,
-0.015213359,
-0.023051346,
0.016905202,
-0.007249807,
0.014724311,
-0.0016183194,
-0.0068532815,
0.018491304,
0.003203595,
-0.022641603,
-0.00481448,
0.01797582,
-0.035607986,
0.038066443,
-0.02802113,
0.015781714,
0.016786244,
0.013970913,
-0.006773976,
0.0036711649,
-0.02446562,
-0.008703734,
-0.00037236218,
0.005306832,
-0.0011094451,
-0.032990918,
0.0050457865,
-0.018953916,
-0.023421437,
0.01616502,
-0.025694849,
0.0410536,
0.03994333,
-0.017737905,
0.019138962,
0.032144997,
0.0008839213,
-0.009582698,
0.007388591,
0.023170304,
-0.034735627,
-0.034497716,
-0.057469755,
0.03153699,
-0.029422188,
-0.007877639,
0.013732998,
0.007745464,
-0.0027046339,
-0.03174847,
-0.00063898426,
-0.017566077,
-0.009972615,
-0.0045236945,
-0.018782089,
-0.012662379,
-0.015120837,
0.024069095,
-0.028682007,
0.0084393835,
0.018147647,
0.012279071,
-0.014235264,
-0.012913512,
-0.0148961395,
-0.0060833613,
0.029237144,
0.008340252,
-0.0007273764,
-0.008968084,
-0.012569857,
0.013158036,
-0.0022965432,
0.005346485,
0.013415777,
-0.0076925936,
-0.04057777,
-0.042533964,
0.009642177,
0.0014299699,
-0.012649162,
0.013395951,
-0.01839878,
0.004302301,
0.0047351746,
-0.006281624,
-0.01600641,
-0.024121964,
0.002529502,
-0.030664634,
-0.010679752,
-0.013395951,
-0.021993944,
0.025681632,
-0.007163893,
0.023685787,
0.017328162,
0.00009056063,
-0.031351946,
0.015279447,
0.014671441,
0.0011978373,
-0.022535862,
-0.0061824927,
0.022535862,
-0.014737529,
0.0026501117,
0.014539266,
-0.057522625,
-0.008115554,
-0.0038033398,
-0.016389718,
-0.015041532,
-0.016032845,
-0.00001128781,
0.01595354,
0.01303247,
-0.019442964,
-0.029052097,
-0.0018983656,
-0.012080808,
0.017367814,
0.014089871,
-0.030664634,
0.0059544905,
0.010858188,
-0.041450128,
0.038727317,
0.013415777,
-0.023104217,
-0.013693346,
-0.04041916,
0.0037405568,
-0.02622355,
-0.009133303,
0.005802489,
-0.020249233,
0.018068343,
0.010699579,
0.020183146,
0.001107793,
0.029580798,
-0.024597796,
0.005339876,
-0.0050226557,
-0.009391044,
-0.01600641,
-0.030373849,
-0.010567403,
0.02643503,
0.0001547895,
0.011208452,
0.0025179365,
-0.010355923,
0.008128772,
-0.018755654,
0.01516049,
0.011730544,
0.004447694,
-0.02759817,
0.026990166,
0.040234115,
-0.021359503,
-0.017751122,
0.022892736,
0.008802865,
-0.010911059,
-0.02015671,
0.009510002,
0.011287758,
0.0075934622,
0.007573636,
0.03365179,
-0.017301727,
-0.006552583,
-0.017843645,
0.009430697,
-0.0013258819,
0.016389718,
-0.01553058,
-0.0061659706,
-0.029316448,
0.024928233,
-0.0023510654,
-0.007573636,
-0.010349314,
-0.008518688,
-0.0013184471,
0.00771242,
-0.00195454,
0.017195987,
-0.0039586457,
0.0129796,
-0.0058090976,
0.010230357,
0.008340252,
0.037511308,
0.023064563,
0.005838837,
0.02165029,
0.0059181424,
0.013785868,
0.0038231662,
0.021584202,
-0.031827778,
0.022575516,
-0.03201282,
0.04367067,
0.0058850986,
-0.0711631,
-0.005049091,
0.009384436,
-0.032911614,
0.026725816,
0.01915218,
-0.0063576247,
0.07322503,
0.008141989,
-0.022588734,
-0.023368565,
-0.0040941252,
0.020566452,
-0.002712895,
0.00089713885,
0.0050127427,
-0.04409363,
0.034656323,
-0.031933516,
0.02170316,
-0.04430511,
-0.015702408,
0.026025286,
-0.013997348,
0.0014828399,
0.011571934,
0.002172629,
0.023051346,
0.006645106,
0.00063113635,
0.012312115,
-0.03084968,
-0.00025340455,
0.037775658,
-0.024637448,
-0.014578919,
-0.0077520725,
0.0141030885,
-0.008479035,
-0.015517362,
-0.004431172,
0.022866301,
-0.01734138,
0.004424563,
-0.012972991,
0.0094835665,
0.011241497,
-0.013521518,
0.011823067,
-0.011717327,
-0.035766594,
0.0068863253,
-0.008981301,
0.0012581422,
-0.008954866,
-0.002205673
] |
Autoantibodies to DNA and histones (chromatin) are the defining antigen specificity in systemic lupus erythematosus (SLE) and related musculoskeletal disorders but the mechanisms responsible for their induction remain mysterious. That situation rapidly changed once neutrophil extracellular chromatin traps (NETs) were discovered and observed to play a conserved role in innate immune responses to a broad variety of microbial pathogens. At the center of an infectious process, neutrophils exert various antimicrobial defenses, including the release of nuclear chromatin into the extracellular space. The externalized NETs, a complex meshwork of nuclear chrom
|
[
-0.018997865,
0.008243716,
-0.0013077995,
-0.015890356,
-0.030396584,
0.016677411,
-0.003029481,
-0.018889306,
-0.025063612,
0.003942057,
0.00016230876,
-0.002944669,
0.0038809923,
0.016283885,
0.00077390857,
0.012545376,
0.03682872,
-0.009044341,
-0.025755677,
-0.019812059,
-0.04890593,
0.0026580049,
0.009946739,
-0.012009365,
-0.009817825,
0.0004405978,
-0.0018997865,
-0.058893383,
-0.028605357,
-0.0030108222,
0.0018353295,
-0.007985888,
-0.0137530975,
-0.0063914247,
-0.006530516,
0.001475727,
0.015985345,
-0.009756761,
0.013189946,
0.019187843,
0.0105098905,
0.0060861018,
-0.0056145475,
-0.011242665,
-0.008718663,
-0.0017386439,
0.0007387116,
-0.0025189132,
-0.006140381,
-0.0063473224,
0.036611598,
0.015076162,
-0.022105373,
0.00315161,
-0.023462363,
-0.028116839,
-0.0023866068,
0.0052786926,
0.033409104,
-0.022227501,
-0.008596534,
0.0029752012,
-0.031183638,
0.004498423,
-0.008060522,
0.001825152,
0.007979103,
0.019296402,
-0.012368967,
0.00031846866,
0.017057369,
0.016419584,
0.004640907,
-0.010645589,
0.0015071074,
-0.016093906,
-0.0028242362,
0.0005830818,
-0.010001019,
0.0009159685,
0.018712897,
-0.008223361,
-0.021684706,
0.012362182,
0.018875735,
-0.0048648105,
-0.0020728027,
0.0015842862,
0.028605357,
-0.006069139,
-0.0025731928,
0.0120704295,
0.031346478,
0.0045086006,
-0.020884082,
0.034277577,
0.011561558,
0.010062084,
-0.0033314114,
-0.024751503,
-0.0001540396,
0.008074093,
-0.031617876,
-0.018699327,
-0.02534858,
-0.001119517,
0.01684025,
-0.017613735,
0.005926655,
-0.006574618,
-0.0125182355,
0.019337112,
-0.00047876316,
-0.054225333,
0.03791431,
-0.013407065,
0.009376803,
-0.008013028,
0.0018302407,
0.0057400693,
0.0043796864,
0.037100118,
0.018305799,
-0.020816231,
0.025443569,
0.005217628,
-0.020639824,
-0.019106423,
-0.010387761,
-0.0007217492,
-0.008291211,
0.011683687,
0.010055298,
0.006018252,
-0.016460292,
0.008318351,
-0.016093906,
-0.007918038,
-0.015632529,
-0.029853787,
0.020300575,
0.04089969,
-0.011602268,
0.00041939484,
0.02393731,
0.022254642,
-0.003456933,
0.012240053,
0.011106966,
0.00076118676,
-0.007829835,
-0.019364253,
-0.0030040373,
-0.01694881,
-0.0076602106,
0.022308921,
0.007415952,
0.03205211,
-0.027641892,
-0.02224107,
-0.012884623,
-0.0052142353,
0.012667505,
-0.005712929,
0.0052956548,
0.03663874,
-0.0038809923,
-0.0020999426,
-0.001639414,
0.0067544193,
-0.01333243,
-0.0011983921,
-0.028496796,
0.007158124,
-0.022756727,
0.018930016,
0.0042711273,
0.00911219,
-0.038837064,
-0.02547071,
-0.0053499346,
0.021752555,
0.032079253,
-0.02243105,
-0.0074905865,
0.0011084914,
0.022051092,
-0.04342369,
-0.003456933,
-0.0022984024,
0.00067595084,
0.0023832142,
-0.013990571,
-0.02693626,
-0.6283408,
-0.0030939379,
0.038945623,
-0.017952982,
0.007884114,
0.019947758,
-0.0014002444,
-0.0038606375,
-0.023720192,
0.015089733,
-0.021616856,
-0.005916478,
0.017695153,
-0.013617398,
-0.009532857,
-0.048770234,
-0.022838147,
-0.010401331,
0.03091224,
0.007022425,
-0.0011916071,
-0.013169591,
-0.015754659,
0.00039882795,
0.0023916955,
-0.0006246396,
0.0024832922,
-0.009505717,
0.00918004,
0.02125047,
-0.030695122,
0.008813652,
-0.017776573,
0.008128372,
0.04516064,
0.00085447985,
-0.016175324,
0.04890593,
0.034114737,
0.017193068,
-0.011106966,
-0.012721784,
0.00528887,
-0.0065814033,
-0.008657598,
0.03823999,
-0.0039386647,
0.022132512,
-0.0027767415,
-0.0017793536,
0.024249418,
-0.002508736,
-0.0040099067,
0.013685248,
-0.0010423382,
0.025524989,
0.012090784,
-0.02267531,
0.014845475,
0.009654987,
-0.0069206506,
0.014764055,
-0.019079285,
-0.027641892,
-0.031807855,
0.007198834,
-0.022037523,
-0.0062353704,
0.0059775426,
0.0046850094,
0.015971776,
0.026909119,
-0.0044543208,
-0.001262001,
0.016161755,
0.021426877,
-0.011737966,
-0.002445975,
-0.032513488,
0.008270856,
-0.014764055,
-0.001660617,
-0.01400414,
-0.012525021,
0.0396784,
-0.009695696,
-0.022892427,
0.030260885,
-0.0022288566,
-0.0152932815,
-0.012558945,
0.009159685,
-0.017559456,
-0.021833975,
-0.016528143,
0.014397668,
0.003450148,
-0.0035146049,
-0.008189437,
-0.0141127,
-0.010190997,
-0.0195678,
-0.0040099067,
-0.0026987146,
0.028931035,
0.009749976,
-0.03487465,
0.009777116,
0.046734747,
-0.027899722,
0.0045391326,
-0.0060793166,
-0.02963667,
-0.01198901,
0.003650304,
-0.007273468,
0.006662823,
0.016528143,
0.005875768,
-0.023652341,
0.016229605,
0.0039522345,
-0.006215016,
-0.019771349,
-0.00911219,
0.01696238,
-0.0085219,
-0.031807855,
-0.013488484,
-0.031672154,
-0.0035383522,
0.0071377694,
0.016365303,
-0.009614277,
0.025660688,
0.015008314,
0.03245921,
-0.007999458,
-0.000998236,
-0.043287992,
-0.01829223,
-0.021901824,
-0.00078959874,
0.018970724,
-0.0013323949,
-0.0028751232,
-0.017342336,
-0.0035553146,
0.0057197143,
0.0155375395,
0.0052074506,
0.013040677,
-0.017640874,
0.00918004,
0.017885132,
-0.0040099067,
-0.008657598,
-0.034603253,
-0.0089289965,
-0.017478036,
0.020300575,
-0.0010711743,
-0.012932118,
0.030070907,
-0.0067544193,
-0.004620552,
0.0025748892,
0.013719172,
-0.0014528278,
-0.027424775,
0.0066051506,
-0.004834278,
-0.034304716,
0.0058825533,
0.0062082307,
0.028551077,
-0.0070834896,
-0.007816264,
0.0002550718,
-0.00041282192,
0.013922721,
-0.002944669,
0.00048639622,
-0.014736915,
0.016297454,
0.021304749,
0.04811888,
0.009227535,
0.007965533,
0.015144012,
-0.007361673,
-0.0069545754,
-0.042609498,
0.017057369,
0.006452489,
-0.020517694,
0.0054177837,
0.017125217,
0.01540184,
0.02386946,
-0.020015607,
-0.014316248,
0.0055908,
-0.01544255,
0.012769279,
-0.02960953,
0.010360621,
-0.021521866,
0.002951454,
-0.0065610483,
-0.0065847957,
0.0062421556,
0.0048274933,
-0.009736406,
-0.000044208202,
0.024832923,
0.0012713303,
0.0013391798,
0.001532551,
0.00079807994,
0.0021474373,
0.0019591548,
0.035770264,
-0.00974319,
-0.0042745196,
0.013257796,
0.0062251934,
0.01565967,
0.001362079,
-0.016338164,
-0.024208708,
0.0057739937,
0.016446723,
0.0031244704,
-0.0017403401,
0.014655496,
0.022566749,
0.0012365575,
0.026312042,
-0.022566749,
-0.010055298,
0.0010347051,
-0.008840792,
0.011927946,
0.017450895,
-0.021141909,
0.026922688,
0.0042745196,
0.0054720636,
0.0075652213,
-0.009933169,
-0.0021067276,
-0.024181567,
0.01346813,
-0.0040234765,
0.000038695427,
-0.012009365,
0.012022935,
0.05023578,
0.00983818,
0.038429968,
-0.021372598,
-0.0006479629,
-0.016419584,
0.0017640875,
-0.01548326,
0.01665027,
-0.0105302455,
0.010889848,
0.006557656,
-0.025497848,
0.010991622,
0.006717102,
-0.011615837,
0.018129392,
0.010333481,
0.01954066,
0.012368967,
0.016012486,
0.00036405507,
-0.015808938,
-0.03908132,
0.033110563,
0.015591819,
-0.014899754,
-0.015931066,
-0.020259866,
-0.014560507,
-0.012979613,
0.04342369,
0.012986397,
0.018400788,
0.0211012,
0.0040031215,
-0.017383046,
0.0021372598,
0.025728537,
-0.034114737,
0.013244226,
-0.012979613,
-0.0030413547,
-0.013793807,
-0.0062930426,
-0.0065983655,
0.024792213,
0.012185773,
-0.0070495647,
-0.0036536965,
-0.014261968,
-0.034603253,
0.0057638166,
0.0030413547,
-0.0015172848,
-0.008793297,
-0.025484279,
0.0068188766,
-0.0016979341,
0.00050378265,
0.006310005,
-0.009695696,
-0.021684706,
-0.045703433,
-0.010998406,
0.003365336,
0.017695153,
0.022892427,
-0.011832956,
0.03232351,
-0.007958748,
0.008562609,
-0.0026274726,
-0.018563628,
0.022648169,
-0.017613735,
0.0005326187,
0.00841334,
0.00671371,
0.038755644,
0.021223329,
0.028822474,
0.024805784,
-0.0012823559,
-0.027370496,
0.0122536225,
0.0057570315,
-0.010224923,
0.023638772,
0.037235815,
0.016419584,
-0.018387219,
-0.01267429,
0.011039116,
0.0075245113,
-0.040953968,
-0.0014892969,
0.020287005,
0.009044341,
0.003663874,
-0.025633547,
-0.029066732,
0.009281814,
0.039461277,
0.0047562514,
0.000926994,
0.013176376,
0.0065780105,
0.02116905,
0.0021050312,
-0.00229501,
-0.0006721343,
0.029310992,
0.021752555,
-0.002259389,
-0.017695153,
0.01948638,
-0.01837365,
0.001860773,
-0.0155782495,
0.008644029,
-0.022905996,
-0.0077552,
-0.005319402,
-0.0013340912,
-0.011832956,
-0.0025477493,
-0.007449877,
0.0068256613,
-0.011147676,
-0.02528073,
-0.01185331,
-0.0030125186,
-0.0033280188,
-0.042582355,
-0.0048274933,
-0.0045391326,
-0.052542664,
-0.04073685,
0.02671914,
0.032594908,
0.010319912,
0.022037523,
-0.012301117,
-0.0016623131,
0.022865288,
-0.016270313,
-0.000406249,
0.013217086,
-0.05048004,
0.032757748,
-0.008094448,
0.019106423,
-0.015523969,
-0.023055267,
0.0048274933,
0.02395088,
-0.013841301,
0.022254642,
0.028415378,
-0.0018031009,
0.015931066,
0.011486923,
0.040275473,
-0.0044373586,
-0.019391391,
-0.020965502,
-0.050154362,
-0.011819386,
-0.017993692,
0.0024799,
-0.028659636,
-0.012918548,
-0.000320801,
-0.009376803,
-0.009146115,
0.0036944062,
-0.011514063,
-0.01542898,
0.0000072818966,
-0.0027122844,
0.019242123,
-0.013094957,
0.023570921,
-0.0039149174,
-0.013420635,
0.00069630565,
-0.015252572,
0.009247889,
-0.0039658044,
-0.0078026946,
0.006408387,
-0.0020829802,
-0.023557352,
0.000005164912,
-0.024778644,
-0.0154154105,
0.038701363,
-0.009159685,
-0.044047907,
-0.016338164,
-0.005746854,
-0.014533366,
0.007836619,
0.014370528,
-0.009872105,
0.008555824,
0.0036333415,
-0.015808938,
-0.011385149,
0.01197544,
-0.034847513,
0.003278828,
0.021942534,
-0.020558404,
0.015727518,
-0.008677953,
-0.015768228,
-0.0059775426,
0.0041931,
-0.013787022,
-0.027044818,
-0.0012094176,
0.0012365575,
0.06274723,
0.028469658,
0.027872581,
-0.009546427,
0.031427898,
0.008420125,
0.0064049945,
0.0050208643,
-0.012715,
0.02952811,
-0.008718663,
0.015171152,
-0.0012535198,
-0.013454559,
-0.00044780681,
-0.020476984,
0.012952473,
0.02662415,
-0.004427181,
-0.04507922,
0.00842691,
-0.04640907,
-0.0068120915,
0.03365336,
-0.010238492,
0.015266141,
-0.0310208,
0.003806358,
0.030070907,
-0.00016199073,
0.0078094793,
-0.018102251,
0.031590734,
-0.020232726,
0.017125217,
-0.026379893,
0.0029548465,
-0.0016699462,
-0.002702107,
0.0055500907,
0.007266683,
0.012491096,
0.013196731,
0.023611631,
0.014994743,
0.0050446116,
0.005424569,
-0.0015427284,
-0.011561558,
-0.034928933,
-0.03248635,
-0.017980121,
0.0010109578,
0.0014536759,
-0.015741087,
-0.047304682,
0.012341827,
0.006181091,
0.005682397,
0.01811582,
-0.017247347,
-0.0035519223,
0.025633547,
-0.018753607,
0.0006806155,
-0.036285922,
0.0089697065,
0.017423756,
-0.0014740308,
-0.02941955,
-0.0054381387,
-0.022688879,
0.008026598,
0.044400726,
0.018780746,
-0.016623132,
0.010075653,
0.00037465655,
0.009817825,
-0.000119266726,
-0.027981142,
0.018848596,
-0.011636192,
0.007158124,
-0.01678597,
-0.019893479,
-0.009695696,
0.014655496,
-0.017423756,
0.010285987,
-0.005126031,
-0.0062082307,
-0.009573567,
0.0041456055,
-0.030260885,
0.040438313,
-0.019459242,
-0.011955085,
-0.004101503,
-0.01681311,
0.0097839,
0.0040879333,
-0.009621061,
0.047141843,
0.01116803,
0.005370289,
0.018767176,
0.027316216,
-0.0019727247,
-0.01837365,
0.007320963,
0.048335996,
-0.0023628594,
0.008800082,
0.017193068,
0.027329786,
0.010157073,
0.00019761172,
0.0031397364,
-0.001012654,
-0.026692,
-0.015266141,
0.016460292,
0.013162807,
-0.009729621,
-0.012497881,
-0.027071957,
0.011724397,
-0.027316216,
-0.0054517086,
0.016663842,
-0.039976936,
-0.01821081,
0.007951964,
-0.015320421,
0.014560507,
0.00848119,
0.002103335,
-0.0125385905,
0.009634632,
-0.020721242,
0.030288024,
0.0028479835,
0.009587137,
-0.014248398,
0.006381247,
-0.0070970594,
-0.012816774,
-0.0022254642,
-0.00050929544,
-0.017057369,
-0.0011390238,
0.000059580358,
0.009763545,
0.041333925,
-0.03091224,
0.040519733,
-0.0001318825,
0.0308851,
0.00027797098,
-0.007130984,
0.02681413,
-0.009322524,
-0.010638804,
0.026366321,
-0.00489195,
-0.017518746,
-0.0008803475,
0.0024035692,
0.018780746,
-0.009254674,
-0.028496796,
-0.0067951293,
0.001889609,
0.0025036472,
-0.010224923,
0.0055908,
-0.0075312965,
-0.011771891,
-0.017070938,
-0.012178988,
0.0014850564,
-0.0026257762,
0.004800353,
-0.006116634,
0.0031923198,
-0.026515592,
0.0226346,
-0.01836008,
-0.02941955,
-0.020192016,
0.021820405,
-0.011025546,
0.044047907,
0.0197035,
-0.006252333,
-0.006764597,
0.0075516514,
-0.027981142,
-0.024792213,
-0.009906029,
-0.007850189,
0.0155104,
0.023136685,
0.002937884,
-0.017410185,
-0.007395597,
0.0108355675,
0.004939445,
-0.015021883,
0.0075109415,
-0.016378874,
0.037860032,
0.0046951864,
-0.03653018,
-0.0077891247,
0.028306818,
-0.007972319,
-0.021820405,
0.025497848,
0.0056857895,
0.017735863,
-0.0022000205,
0.019106423,
-0.013020323,
0.010598094,
0.01400414,
-0.016243175,
0.0029480616,
-0.0044644983,
-0.0031923198,
-0.019079285,
0.00634393,
0.030505143,
0.020490553,
-0.007680565,
-0.031780712,
-0.029935207,
0.0058995155,
-0.007836619,
0.034603253,
0.02800828,
0.006116634,
0.01340028,
-0.010211352,
-0.016677411,
-0.0015656276,
-0.02673271,
0.0022763512,
-0.011005192,
-0.004813923,
-0.012382537,
0.0037181536,
0.022824578,
0.013617398,
-0.022254642,
0.012280762,
-0.0090918355,
0.005573838,
-0.035390306,
0.0017793536,
-0.0032957902,
0.012748924,
0.0070902747,
-0.014587646,
-0.008236932,
0.008793297,
0.0059707575,
0.011527633,
0.000052715895,
0.009268244,
0.0039250944,
-0.004240595,
-0.016338164,
-0.013807377,
-0.02267531,
-0.02803542,
-0.0022933136,
0.18444213,
-0.0056722197,
-0.0053804666,
0.0062998277,
-0.031780712,
-0.028985314,
0.0018641655,
0.003599417,
-0.0016852124,
0.023068836,
0.036801577,
0.005926655,
-0.014479087,
0.002145741,
0.00664586,
-0.013162807,
-0.006944398,
0.015944637,
-0.017247347,
-0.005068359,
0.012178988,
0.003592632,
0.012715,
-0.0035553146,
0.02537572,
-0.008501545,
0.0056145475,
0.0062964354,
-0.0008591445,
-0.00061531033,
-0.034033317,
0.02253961,
0.015198292,
-0.024493676,
0.008270856,
-0.013583473,
-0.011649762,
0.0050378265,
0.00023726128,
0.018102251,
-0.0011118839,
-0.016121045,
0.0011559861,
0.0024985585,
0.0056654345,
-0.0042880895,
-0.0023950879,
-0.03213353,
-0.003786003,
0.010224923,
-0.02125047,
-0.011704042,
0.0026529161,
0.012884623,
0.020599114,
0.004729111,
0.019255692,
0.010353836,
-0.006432134,
0.014926894,
-0.0035688847,
0.0074091675,
-0.041279647,
0.033137705,
-0.0071716937,
0.045377757,
-0.009546427,
-0.008582964,
0.018794317,
-0.020069888,
0.017328767,
-0.02125047,
-0.0054143914,
-0.014750485,
0.004796961,
-0.01262001,
0.026257763,
0.010387761,
0.025904946,
0.013827732,
0.010903417,
-0.0092953835,
-0.04092683,
0.025077181,
0.00015011706,
-0.043993626,
0.021942534,
0.002266174,
-0.034277577,
-0.027696174,
-0.005017472,
-0.0066356827,
-0.017383046,
0.0013323949,
0.02530787,
-0.016487433,
0.020707672,
-0.0010491231,
-0.01822438,
-0.01123588,
-0.028415378,
0.09167827,
0.0060250373,
0.03530889,
-0.010401331,
0.017070938,
0.0016597689,
0.0028903894,
-0.004033654,
0.0053770742,
0.02247176,
-0.018400788,
0.0057366765,
-0.0075516514,
-0.01960851,
0.031455036,
-0.022526039,
-0.023028126,
0.045893412,
0.006265903,
0.008379416,
-0.012145064,
0.012307903,
0.012036504,
-0.00385046,
-0.0036095942,
-0.014831904,
0.016256744,
-0.0018200633,
-0.038375687,
-0.01548326,
0.0028768196,
0.007897683,
0.008046953,
0.006272688,
-0.007151339,
0.0056315097,
-0.01189402,
0.00019708164,
0.012267193,
-0.0024391902,
-0.017193068,
0.031482175,
-0.00032143708,
-0.015686808,
-0.002666486,
0.0076873503,
0.02388303,
-0.025619978,
-0.009641416,
-0.015008314,
-0.005014079,
0.008793297,
-0.0050242567,
0.0058214883,
-0.035770264,
-0.014818335,
-0.017966552,
-0.014641926,
0.00560437,
-0.037452932,
0.006109849,
0.017518746,
-0.0058282735,
-0.004440751,
-0.0032805242,
-0.17163214,
0.014411237,
0.004026869,
-0.019174274,
0.021440448,
0.037778612,
0.0009872104,
0.013230656,
-0.020300575,
0.0057197143,
0.02800828,
-0.0024832922,
-0.038212847,
-0.037290096,
-0.009912814,
-0.0022627814,
0.0140584195,
0.05086,
0.03216067,
0.009763545,
0.013759882,
-0.023584493,
0.023109546,
-0.030043766,
0.004084541,
0.029718088,
0.027709743,
0.005319402,
-0.0078094793,
-0.014628356,
0.003565492,
-0.014696205,
0.035580285,
0.0026071176,
0.024561524,
0.018916445,
0.013033892,
0.009186825,
0.0074905865,
0.009614277,
0.020504124,
0.0051837033,
-0.001760695,
0.0064016017,
0.00044950304,
0.028632496,
-0.010143503,
-0.01698952,
0.0152932815,
-0.022349631,
0.004834278,
-0.0060962792,
0.012999968,
0.023380943,
0.011005192,
0.005824881,
-0.0065440857,
0.02666486,
0.010699869,
0.010340266,
-0.0034450593,
-0.0336805,
0.041279647,
0.0075516514,
-0.0066492525,
-0.023380943,
0.0059130853,
0.034141876,
-0.008834007,
0.008840792,
-0.015333991,
-0.009729621,
0.0009702481,
-0.0053092246,
0.019282833,
0.022308921,
-0.016392443,
0.022308921,
-0.0089086415,
-0.008962921,
-0.0155782495,
0.0077077053,
-0.003421312,
-0.026122063,
-0.0091732545,
0.0024069615,
-0.011296945,
0.009017201,
0.0035349599,
0.007992673,
0.015998917,
-0.03240493,
0.015713949,
-0.011785461,
0.017749434,
0.019852769,
0.00026864168,
-0.0049360525,
-0.027180517,
0.0046137674,
0.006072532,
-0.035987385,
-0.011995794,
0.0138955815,
-0.002615599,
0.00022369137,
-0.00025422365,
0.009471793,
0.04073685,
-0.027411206,
-0.01256573,
-0.0030532284,
0.016378874,
0.032839168,
-0.009485362,
0.02684127,
0.019282833,
0.0007692439,
0.0006971538,
-0.03370764,
0.0734946,
0.011283374,
0.006483021,
0.01825152,
-0.0107337935,
-0.02095193,
-0.13135667,
-0.013739527,
-0.014736915,
0.011914375,
-0.012776064,
0.014302678,
-0.010421686,
0.039027043,
-0.015388271,
0.01708451,
-0.0075245113,
0.0038470677,
-0.015931066,
-0.004769821,
-0.005980935,
0.005753639,
-0.0014231437,
-0.011073041,
-0.026447741,
0.035987385,
0.012307903,
0.005818096,
0.00087356253,
-0.016311023,
0.020124167,
0.0010796555,
-0.02095193,
0.039461277,
0.014574076,
0.0106523745,
-0.004746074,
-0.0120704295,
-0.006930828,
-0.020490553,
-0.019377822,
-0.009587137,
-0.014221258,
-0.019852769,
0.035390306,
-0.010727009,
-0.020327715,
0.00670014,
0.01116803,
0.006910473,
0.013047462,
0.00085023924,
-0.008576179,
0.004243987,
0.031265058,
-0.00041536626,
-0.01700309,
-0.027384065,
-0.047983177,
-0.008637244,
0.017070938,
-0.00079171907,
-0.00067595084,
0.01819724,
-0.035200328,
-0.009437867,
0.013685248,
0.0023950879,
-0.002052448,
-0.0027767415,
0.012966042,
-0.0075109415,
-0.02104692,
-0.009946739,
0.01120874,
-0.014764055,
0.0011025546,
-0.013271365,
-0.025769247,
0.0045052078,
-0.014546936,
-0.0068120915,
-0.027546903,
-0.0023255423,
0.00774163,
-0.02116905,
-0.015116872,
-0.010001019,
0.010204568,
-0.010062084,
0.045730576,
0.0026461312,
0.009532857,
0.0063337525,
-0.011846526,
-0.002374733,
-0.015646098,
0.029202431,
0.0036977986,
-0.010435256,
0.009831395,
0.014126269,
-0.020232726,
-0.03346338,
0.031943552,
0.028551077,
-0.016419584,
-0.022756727,
-0.06345287,
-0.0072191884,
-0.0013824339,
-0.008257287,
0.014519797,
-0.024778644,
0.008834007,
-0.018346509,
0.010435256,
0.02251247,
-0.03216067,
0.012789634,
0.00050675106,
0.02116905,
-0.03490179,
-0.03530889,
0.017450895,
0.01708451,
0.020843372,
0.028279679,
-0.004104896,
-0.012531806,
0.0017318589,
0.03264919,
0.005132816,
-0.0078026946,
-0.020734813,
0.011724397,
-0.017640874,
-0.024534386,
0.0077484148,
-0.048797373,
-0.013766667,
0.0012136583,
-0.020979071,
-0.029989487,
-0.009899245,
0.022811007,
0.0025714966,
0.031482175,
-0.022078233,
-0.047087565,
-0.0024578488,
0.015605389,
-0.019092854,
-0.0061369888,
-0.03663874,
0.017735863,
-0.00085575203,
-0.0008701701,
0.029446691,
-0.0015020187,
-0.005017472,
-0.04339655,
-0.020287005,
0.018699327,
0.0052583376,
0.000094088195,
0.013549549,
-0.003187231,
0.014248398,
0.034603253,
0.011765107,
-0.0034671102,
-0.014696205,
0.004729111,
-0.022838147,
-0.00026228078,
0.01682668,
-0.0073752427,
-0.009403943,
0.011887236,
-0.00043169255,
0.00026906573,
-0.0028140587,
-0.0011152765,
-0.00664586,
-0.00006122359,
-0.0060793166,
0.014791194,
-0.012240053,
0.004925875,
-0.009763545,
0.01060488,
0.03091224,
-0.021440448,
-0.016066765,
0.029826649,
0.0045527024,
-0.006886726,
-0.004640907,
0.0137123875,
0.002515521,
0.005997897,
-0.014818335,
0.0015664757,
0.0064728437,
0.020666962,
0.021711845,
0.03672016,
0.01987991,
0.010889848,
0.0057197143,
-0.021806834,
-0.009485362,
0.027533334,
-0.03889134,
-0.0070834896,
0.00093208277,
0.014546936,
0.020232726,
0.0077823396,
-0.0026851445,
0.0052447678,
-0.020761952,
0.023095975,
-0.016148185,
0.0022780476,
-0.018726466,
0.0064219567,
0.02538929,
0.01189402,
-0.012450387,
-0.0014816638,
0.0044848532,
0.0022271604,
0.0088068675,
-0.021915395,
0.029093873,
-0.008250501,
0.014194119,
-0.0019642436,
-0.0422024,
0.005889338,
-0.02662415,
0.0046816166,
0.023245245,
0.02677342,
-0.001589375,
0.09124403,
0.023041695,
-0.026244193,
0.01948638,
-0.00770092,
-0.00075949053,
0.031427898,
-0.004983547,
0.007293823,
-0.012789634,
0.036340203,
-0.014465517,
0.027899722,
-0.02960953,
-0.022702448,
0.02684127,
-0.020558404,
0.019472811,
-0.015876787,
-0.020097027,
0.008297996,
0.007938393,
0.001283204,
0.0033280188,
-0.013603828,
0.015062593,
0.02386946,
-0.031210778,
0.014166979,
-0.016758831,
-0.007585576,
-0.005227805,
-0.037778612,
-0.01685382,
0.008318351,
0.004471283,
-0.002766564,
-0.018957155,
0.011744752,
-0.004606982,
0.006981715,
0.028415378,
0.0138141615,
-0.015320421,
0.010747364,
0.004186315,
-0.014831904,
-0.0070767044,
-0.002659701
] |
Kit/SCF signaling and Mitf-dependent transcription are both essential for melanocyte development and pigmentation. To identify Mitf-dependent Kit transcriptional targets in primary melanocytes, microarray studies were undertaken. Among identified targets was BCL2, whose germline deletion produces melanocyte loss and which exhibited phenotypic synergy with Mitf in mice. BCL2's regulation by Mitf was verified in melanocytes and melanoma cells and by chromatin immunoprecipitation of the BCL2 promoter. Mitf also regulates BCL2 in osteoclasts, and both Mitf(mi/mi) and Bcl
|
[
-0.023781467,
-0.014637811,
-0.0020470375,
-0.025665935,
-0.011784566,
0.038193673,
-0.029010205,
0.017053116,
-0.019282628,
-0.008300953,
0.012249048,
-0.002891399,
0.004810704,
0.009528511,
-0.039122634,
-0.001056696,
0.024179593,
-0.008805247,
-0.001750101,
0.03670733,
-0.033973522,
0.051809624,
0.0007825688,
-0.016137423,
-0.0068212464,
-0.0005835052,
0.004170383,
-0.04108673,
-0.020530093,
-0.013708848,
0.010882144,
-0.0053050453,
-0.01030486,
0.0004223881,
-0.014014078,
-0.010649904,
0.0006589835,
-0.024391929,
0.010211963,
-0.00310871,
0.005879012,
0.014637811,
-0.008778705,
-0.0035632388,
0.008493381,
0.0027371247,
0.022003165,
-0.0008468498,
-0.014863417,
0.019800194,
0.0049865437,
0.015951632,
-0.0049998146,
-0.019242816,
-0.010921957,
0.0012574185,
0.008314224,
0.02325063,
-0.0013428499,
-0.01624359,
0.0015825557,
-0.0032331247,
-0.017132742,
0.013569503,
0.009840378,
-0.0036096869,
0.009873555,
0.00092481636,
-0.00036246167,
0.009163561,
0.046872847,
0.03540678,
0.0030805094,
0.0035897805,
0.03726471,
-0.01433258,
-0.021551954,
-0.002937847,
-0.0021814054,
-0.0032779141,
0.02325063,
0.010576913,
-0.008433661,
0.03538024,
0.010603455,
-0.0018778334,
0.0030473322,
0.009807201,
0.012136245,
0.019972716,
0.028558994,
0.027006296,
0.025851728,
0.025705747,
-0.01796881,
0.011698305,
0.020543365,
0.040608976,
0.018844688,
-0.01278652,
-0.008619455,
0.004386035,
-0.012613998,
-0.01624359,
-0.03875105,
0.0034703424,
0.0024385292,
-0.009853649,
0.012693623,
-0.0038883758,
-0.015911818,
0.03638883,
-0.01682751,
-0.03158476,
0.010802519,
-0.0029046698,
-0.0070269457,
0.0056069586,
-0.009920004,
0.0018529504,
0.038538717,
0.025227996,
0.011087843,
-0.042307653,
0.03551295,
0.028134324,
-0.003206583,
-0.011758024,
-0.024219407,
-0.0006025821,
0.025626123,
0.002405352,
0.0010890438,
0.007849742,
-0.0138813695,
0.0009994652,
-0.0146510815,
-0.013038667,
-0.010835696,
-0.0056899018,
-0.016429383,
0.028028157,
-0.009873555,
-0.0007120671,
-0.014000808,
-0.000008819192,
0.0028233856,
0.0016854053,
0.008002358,
0.015540233,
-0.01580565,
-0.027709655,
0.021684663,
-0.010948499,
0.024524637,
0.010908686,
0.017013304,
0.028877495,
-0.0020735792,
-0.023635486,
0.008373942,
-0.0078762835,
0.022255313,
0.016309945,
0.045280337,
0.022985213,
0.007717033,
-0.014359122,
0.003048991,
-0.012355215,
0.01666826,
0.009920004,
-0.019070294,
0.03219522,
-0.017437972,
0.020224864,
0.0033741281,
0.018911043,
-0.009608137,
-0.013542961,
-0.031186633,
0.030761963,
0.024060156,
-0.0025364023,
-0.025480142,
0.009840378,
0.01139971,
-0.01857927,
-0.018924315,
-0.011154198,
-0.0018197732,
-0.009203374,
0.019826736,
-0.015341169,
-0.61279744,
-0.0047642556,
0.021724476,
0.0008650973,
-0.004226784,
0.01154569,
0.008745528,
-0.0015385959,
-0.0069406847,
0.021711204,
0.0020835325,
0.031266257,
0.0071729254,
-0.017796287,
-0.0036959478,
-0.035619117,
-0.021313077,
-0.03203597,
0.012441476,
-0.01221587,
-0.039467677,
0.017039845,
0.009992993,
0.037556667,
-0.024046885,
0.01352969,
0.029116372,
-0.011160833,
0.0114461575,
0.015195189,
-0.020052342,
0.037503585,
-0.024922764,
0.013217824,
0.04591734,
0.0083474,
-0.0047543026,
0.036176495,
0.013065209,
0.015115564,
-0.008433661,
0.015181919,
0.039122634,
-0.002514837,
-0.0021482282,
0.025559768,
0.0040343557,
0.0174247,
0.0049500484,
-0.010623362,
0.008055441,
0.015898548,
-0.027603488,
-0.011220552,
-0.013496513,
-0.005746303,
0.032699518,
-0.019388797,
-0.008221327,
0.020490281,
-0.00060507044,
0.026382564,
-0.017769745,
-0.0058391993,
0.0058956007,
0.0059254603,
-0.016893866,
-0.0030423556,
-0.004618276,
0.005875694,
0.022255313,
0.0046713594,
-0.014292767,
0.0042433725,
0.028346658,
0.01917646,
-0.0075179692,
-0.008791977,
-0.0036130045,
0.007352083,
-0.013463336,
-0.026448919,
-0.016893866,
-0.00028034791,
0.02705938,
-0.010046077,
-0.005696537,
0.0020337666,
-0.0124282045,
0.007007039,
0.021392703,
-0.013934453,
-0.009249822,
-0.024790056,
-0.009269729,
0.012567549,
-0.0016472514,
-0.0022859138,
0.011539054,
-0.039122634,
-0.013032031,
0.0015460608,
-0.00054286304,
0.0039514126,
0.02441847,
-0.01402735,
-0.030257668,
-0.000935599,
0.025241267,
-0.011140927,
0.0017832782,
0.01088878,
-0.005862423,
-0.020410655,
0.0046680416,
-0.021259993,
0.02996571,
-0.016840782,
-0.003775573,
-0.0049400954,
0.00551738,
-0.012222506,
0.0029859543,
-0.0037125363,
0.0031534994,
0.00716629,
0.014611269,
-0.012341944,
0.003413941,
-0.012998854,
-0.02076897,
-0.007013675,
0.037185084,
-0.020211592,
0.033442687,
0.002974342,
0.022494188,
-0.00051175937,
0.011227188,
-0.019959444,
-0.026276397,
-0.0016621812,
0.017902454,
0.0064430255,
0.0017335123,
-0.012103068,
-0.015593316,
-0.00064612733,
0.034159318,
-0.015566775,
-0.01242157,
-0.004541968,
-0.020875137,
-0.003851881,
0.03230139,
-0.022918858,
-0.03158476,
-0.01265381,
0.0016090976,
-0.02147233,
0.0037523492,
0.030204585,
-0.020463739,
-0.0048272926,
0.010198693,
-0.0011180739,
-0.0042234664,
0.008486745,
-0.0043661287,
-0.020025799,
0.000108033484,
-0.007637407,
-0.019322442,
-0.0037556668,
0.0024219407,
-0.0038452453,
-0.019282628,
-0.019534776,
-0.023728382,
0.0013387027,
0.014425476,
-0.014558186,
0.0045850985,
-0.010749435,
0.019402066,
0.029461415,
0.011313449,
-0.002224536,
0.002916282,
0.013085115,
-0.018300582,
0.014372393,
-0.0030025428,
0.016907137,
0.010477382,
-0.027112463,
0.006389942,
0.003802115,
-0.006768163,
0.043050826,
0.0047576204,
-0.01577911,
0.03816713,
-0.014797062,
0.001990636,
-0.0053481758,
-0.015168647,
-0.016256861,
0.00028967904,
0.009999629,
-0.00014670573,
0.019348983,
0.0021797465,
-0.027417695,
0.02427249,
-0.011565596,
0.0024949305,
-0.010032807,
-0.006234009,
-0.023330256,
0.0050263563,
-0.0037921618,
0.00347366,
0.003987908,
-0.015553503,
-0.0025181547,
-0.009123749,
-0.020370843,
0.034185857,
0.0069871326,
-0.013403617,
-0.005610276,
0.0066520423,
-0.016442655,
-0.0052685505,
-0.025626123,
0.0063600824,
-0.0064927917,
0.05353484,
-0.003642864,
-0.00033550514,
0.020251404,
-0.010643268,
0.008884872,
-0.010019535,
-0.03155822,
0.013629222,
0.018473104,
-0.0011761342,
0.013735389,
-0.0018347029,
0.01784937,
-0.011512512,
0.0034471182,
0.022852503,
-0.013403617,
0.010192057,
-0.0012101409,
0.020131966,
0.004873741,
0.016920406,
-0.014810333,
-0.0123220375,
-0.023038296,
0.010032807,
0.019508233,
-0.004737714,
-0.000359766,
-0.023224087,
-0.019707298,
-0.023953987,
-0.0012947429,
0.018658897,
-0.03644191,
0.037609752,
0.018380206,
0.028771328,
0.026515273,
0.0120433485,
0.019654214,
-0.009044124,
-0.041909527,
0.013503148,
0.025692478,
-0.029939167,
-0.0054676137,
-0.04153794,
-0.01338371,
-0.029116372,
0.024750242,
0.018061705,
-0.0010268365,
-0.009807201,
-0.0035068374,
0.0010591843,
-0.024498096,
0.014345851,
-0.031186633,
0.0150359385,
0.013304085,
-0.0058027045,
0.01329745,
-0.006379989,
0.0018761746,
0.037689377,
0.0033724695,
-0.009674491,
-0.0022942082,
-0.021167098,
-0.03232793,
-0.008519922,
0.0035201083,
0.0049500484,
-0.014876687,
0.011744753,
-0.0013105021,
0.029806457,
0.012076526,
0.0076241363,
0.008314224,
-0.026820505,
-0.004359493,
0.014398934,
0.013138198,
0.026687795,
0.034106232,
-0.00012285958,
0.0030821683,
-0.006751574,
0.0114461575,
-0.024352115,
-0.018831417,
0.02252073,
-0.039786182,
0.023874363,
-0.01944188,
-0.0043064095,
-0.0018247498,
-0.00071248185,
0.007644043,
0.0018264087,
-0.00045577274,
-0.0015402547,
0.013204553,
0.010656538,
0.0142662255,
0.046607427,
0.042891573,
0.010490652,
0.005089393,
0.0022543955,
0.034451276,
0.010517194,
-0.022772877,
0.006678584,
0.011817743,
0.0053614466,
0.030337295,
0.014491831,
-0.027550405,
-0.011160833,
0.009800565,
0.0005781139,
0.008573006,
0.028638618,
-0.0014490172,
0.014943042,
-0.008579642,
-0.0027736197,
-0.015526962,
-0.011459429,
-0.0022328303,
-0.0004474784,
-0.015686212,
0.012978948,
-0.005334905,
-0.03288531,
-0.02310465,
0.0122357765,
0.0057263966,
-0.0019275993,
-0.010875509,
0.011300177,
-0.010517194,
-0.0075179692,
-0.028107783,
0.00775021,
-0.0015128835,
0.0049964967,
-0.007007039,
-0.0041206167,
-0.04267924,
-0.028134324,
-0.016734615,
0.021220181,
-0.017597223,
-0.027550405,
0.016363028,
0.02060972,
0.02047701,
0.01697349,
-0.017146012,
0.015009397,
0.009050759,
-0.005952002,
-0.009229916,
0.017889183,
-0.02104766,
0.0020354255,
0.016522279,
0.02675415,
-0.02778928,
-0.021379432,
0.014465289,
-0.0023655393,
0.0066288183,
0.0044756136,
-0.0061908783,
0.007179561,
-0.0007120671,
0.011811107,
0.016163966,
-0.0035997336,
-0.019348983,
0.019866548,
-0.0135827735,
-0.01885796,
-0.031770553,
-0.007843106,
-0.004240055,
0.0026890177,
0.009150291,
-0.024949307,
0.0020818736,
0.00062953867,
-0.020981304,
0.0022859138,
0.0015460608,
0.017889183,
0.018937586,
-0.017039845,
0.021711204,
0.017013304,
-0.004880376,
0.019733839,
-0.04358166,
0.033097643,
0.0027404425,
-0.018313853,
0.0033260211,
-0.0056169117,
-0.011957088,
-0.039680015,
0.011028124,
-0.002489954,
0.023648757,
-0.006575735,
-0.0330711,
-0.026953213,
0.0028631983,
0.00030834123,
0.006376671,
-0.0040608975,
0.00055157207,
-0.018366937,
0.0035300613,
0.01205662,
-0.006015039,
0.031053923,
-0.032593347,
-0.014252955,
0.030204585,
0.023423152,
0.005381353,
0.0028864224,
0.0014730707,
-0.036415372,
-0.0063335407,
0.0021581813,
-0.042466905,
0.008884872,
-0.02778928,
0.05056216,
0.040688604,
0.023662029,
0.009515241,
0.026714336,
0.0021648167,
0.0025347434,
-0.0060017677,
-0.02060972,
0.023874363,
-0.010649904,
0.013921182,
-0.033124186,
0.0064363903,
0.037609752,
-0.004810704,
0.011121021,
0.038379464,
-0.012720165,
-0.014505102,
-0.01045084,
-0.017915726,
-0.031266257,
0.034318566,
-0.008659267,
0.023887634,
-0.026807234,
0.0028333387,
0.033548854,
0.026475461,
-0.004250008,
0.015964901,
0.03405315,
-0.016416112,
0.019269358,
-0.011452793,
-0.007936003,
-0.005597005,
-0.003170088,
0.012381757,
-0.01045084,
0.004555239,
-0.0044722958,
0.0038452453,
-0.001171987,
-0.025546497,
-0.007630772,
0.009130385,
-0.029461415,
0.003025767,
-0.005454343,
-0.016309945,
-0.021180369,
-0.027125735,
-0.025904812,
-0.032964934,
0.018871231,
0.020875137,
-0.04095402,
0.027656572,
0.0100991605,
-0.01506248,
0.042785406,
-0.002805138,
0.028028157,
-0.018114788,
0.03498211,
0.0044623427,
0.0059951325,
-0.0034106232,
-0.021671392,
-0.0033923758,
0.013960995,
0.021180369,
0.04225457,
-0.0069738617,
-0.002501566,
0.028399741,
0.011572232,
-0.037662834,
-0.035433322,
0.010172151,
-0.020224864,
0.00088168593,
-0.011996901,
0.006738303,
-0.02954104,
-0.008181514,
-0.03256681,
0.0121296095,
-0.004386035,
-0.020556636,
-0.023171004,
0.02587827,
0.0007792511,
-0.003208242,
0.026064062,
-0.012839603,
0.004833928,
-0.00566336,
0.008765435,
0.0021415928,
-0.013058573,
0.030098418,
0.00031580613,
0.013430159,
0.016907137,
0.0041239345,
-0.004084122,
-0.024033614,
-0.00979393,
0.042493448,
-0.0005208831,
0.0052287374,
-0.008898144,
-0.021167098,
0.008811883,
-0.0002469633,
0.0069539556,
-0.015925089,
-0.024259219,
-0.01301876,
0.035778366,
0.004190289,
0.009860285,
0.018937586,
-0.019110106,
-0.022839231,
-0.008964498,
-0.023516048,
0.023462964,
-0.05106645,
0.009256458,
-0.006147748,
0.029434873,
0.0021697935,
-0.0020238133,
-0.013396981,
0.0018977398,
0.028399741,
-0.01192391,
0.024524637,
-0.0010716257,
0.0072459155,
-0.026793962,
0.0054012593,
-0.0074317083,
-0.0327526,
-0.004259961,
-0.01265381,
-0.033230353,
0.0064596143,
-0.0038850582,
0.018977398,
0.004628229,
-0.03593762,
-0.00884506,
0.003994543,
0.018035164,
0.006111253,
0.0081748795,
0.0046580886,
-0.02690013,
0.0041305698,
0.01331072,
0.00964795,
-0.014053891,
0.010649904,
-0.012673717,
0.00034089643,
-0.012607362,
0.0035366968,
-0.0002465486,
0.019481692,
-0.011293543,
0.004880376,
0.0005884818,
0.0018429973,
-0.026701067,
0.007975816,
0.008154972,
0.001907693,
-0.020808782,
-0.013655764,
0.006379989,
0.014982855,
-0.02281269,
-0.019548047,
-0.0011869168,
-0.032221764,
-0.016190507,
-0.0042301016,
-0.031637844,
0.03758321,
-0.003231466,
-0.00639326,
-0.025387246,
-0.012335309,
-0.056958735,
-0.026010979,
0.0136026805,
0.005945367,
-0.015898548,
0.0061145704,
-0.025201453,
-0.00015074921,
-0.009581596,
0.03232793,
0.007829836,
-0.018526187,
0.0052021956,
0.001646422,
0.020131966,
-0.020158509,
-0.017132742,
-0.01621705,
0.027284985,
-0.010357943,
-0.008108525,
0.034318566,
-0.030045334,
0.017517598,
-0.011645221,
0.032089055,
0.004356175,
0.010663174,
0.030363837,
-0.012998854,
-0.02850591,
0.006061487,
0.016761156,
-0.00024613386,
-0.0009828766,
0.011512512,
0.024405198,
-0.001331238,
-0.014452018,
-0.014571456,
-0.0038850582,
-0.0036163223,
0.0012350238,
0.02954104,
0.028904036,
0.031850178,
0.017889183,
-0.0062870923,
-0.015235002,
0.012030078,
-0.0130054895,
-0.006058169,
-0.0006486156,
0.009495335,
0.002843292,
0.0011155857,
-0.0038120681,
-0.023648757,
-0.017862642,
0.009747482,
-0.020941492,
-0.032381013,
0.009920004,
-0.010178786,
-0.0050263563,
0.0030406967,
0.0032264893,
-0.01725218,
-0.021764288,
0.0099067325,
-0.014452018,
-0.01960113,
-0.0013320673,
0.0036196401,
-0.016734615,
0.014996125,
0.0017268768,
-0.024179593,
-0.007995722,
0.026581628,
0.18812838,
-0.006927414,
-0.006197514,
0.024179593,
-0.009787294,
-0.010344672,
0.026156958,
0.0070999353,
0.0039646835,
0.004163747,
0.00891805,
0.012965676,
0.0066387714,
0.0034570715,
0.015327898,
-0.0058491523,
-0.014359122,
-0.0019873185,
-0.025082015,
-0.010185421,
0.01914992,
-0.019932903,
0.017597223,
-0.011233823,
0.031080466,
0.02484314,
-0.010424298,
0.013629222,
0.018977398,
0.0068345172,
-0.015606587,
0.01404062,
-0.010921957,
0.0016281744,
-0.023237359,
0.0074516144,
-0.029753374,
-0.028558994,
0.014385664,
-0.0003214048,
-0.010178786,
0.00675821,
-0.023622215,
0.00055862224,
0.00347366,
0.006074758,
-0.01352969,
0.018300582,
0.008579642,
-0.0053614466,
-0.0324341,
0.011665128,
0.024299031,
0.02179083,
-0.016469195,
0.000049428945,
0.015460608,
0.020423926,
-0.001402569,
0.027139006,
-0.028930578,
-0.008864966,
-0.016933678,
0.031319343,
-0.01374866,
0.022454375,
-0.022746336,
0.0073918956,
0.02398053,
-0.017318534,
-0.0022859138,
-0.007922731,
-0.007836471,
0.008340766,
0.010019535,
-0.033177268,
-0.0003075118,
0.0042201485,
0.020795513,
0.030576171,
-0.0090773,
-0.010908686,
-0.03569874,
-0.007730304,
0.008314224,
-0.024524637,
0.015434066,
-0.006887601,
-0.009336083,
-0.03829984,
0.013350533,
-0.012866145,
-0.009375896,
-0.00031165898,
0.0062141023,
-0.0027006296,
0.002564603,
-0.0014299403,
-0.018008621,
0.0029693656,
-0.026263125,
0.07649351,
0.01871198,
-0.00017729103,
0.004541968,
-0.006330223,
-0.020994576,
-0.006900872,
-0.019043753,
-0.0116385855,
0.021180369,
-0.025373975,
0.010231869,
-0.00840712,
-0.018074976,
0.0280547,
-0.0045850985,
-0.014889958,
0.026369294,
-0.005149112,
-0.02238802,
-0.025015661,
0.023754925,
0.029806457,
-0.024909493,
0.013105021,
-0.011963723,
-0.012899322,
-0.021140555,
-0.0068079755,
-0.0021797465,
-0.017199095,
0.00059553195,
0.016548822,
0.01784937,
0.003330998,
0.014491831,
-0.011227188,
-0.02091495,
0.0034006701,
-0.008791977,
0.0024003754,
0.00034048173,
-0.0014456995,
0.010278318,
-0.023715112,
0.011864191,
0.004790798,
-0.026502002,
-0.01506248,
-0.025944624,
-0.026581628,
-0.012182693,
-0.0333896,
0.029010205,
-0.02808124,
0.0007614183,
-0.03142551,
0.012527737,
0.00095633476,
-0.02850591,
0.021114014,
-0.0044125766,
-0.00050346507,
-0.010251776,
-0.018778333,
-0.1657271,
-0.00008911207,
0.026993025,
-0.011432887,
0.032381013,
0.013264272,
-0.022016436,
-0.0036262756,
-0.02310465,
0.016044527,
0.03790171,
0.000868415,
-0.031717468,
-0.022852503,
-0.011605409,
0.0072591864,
-0.005961955,
0.04419212,
0.009349355,
0.0102053275,
0.04663397,
-0.026143689,
0.017928995,
-0.024975847,
0.010417663,
-0.0057164435,
0.00840712,
-0.037822086,
-0.008546464,
-0.011738118,
-0.018406749,
0.0062638684,
0.009130385,
-0.0048438814,
0.022839231,
-0.0005130035,
-0.0010542077,
-0.011280271,
0.0027686432,
0.023675298,
0.035592575,
0.03315073,
-0.012633904,
0.010404391,
-0.012103068,
0.056799483,
-0.00036536469,
0.018539459,
0.0056799483,
-0.010716258,
0.033867355,
0.00042155868,
0.01132672,
0.022918858,
0.015633129,
-0.0072193737,
0.009488699,
0.00073072937,
-0.015447336,
0.0082611395,
-0.0022295124,
-0.012673717,
-0.0026740879,
0.00687433,
-0.00043586636,
-0.02792199,
-0.0030423556,
0.020145237,
-0.012594092,
-0.0016563751,
-0.018632354,
-0.001331238,
0.03155822,
-0.027258445,
0.024020342,
0.021180369,
0.0065890057,
0.02557304,
-0.0000279674,
0.017583953,
-0.01680097,
0.027975073,
-0.032142136,
-0.0037822085,
-0.0045884163,
0.012229141,
0.022932129,
0.0030771918,
-0.008566371,
0.0041471585,
0.0027802552,
-0.012136245,
0.0030274258,
-0.01826077,
0.02763003,
0.0020851914,
-0.011147562,
-0.012454746,
0.00041181286,
0.00035271584,
0.04153794,
-0.02808124,
-0.010371214,
0.007617501,
0.039653473,
0.0050164033,
-0.0071530193,
0.010258412,
0.039653473,
-0.0054012593,
-0.0021830644,
-0.018512916,
0.02163158,
0.0066852197,
-0.024949307,
0.017146012,
0.011432887,
0.00070999353,
0.0006826223,
-0.043793995,
0.0696988,
-0.0038916937,
0.00065027445,
0.03301802,
-0.013682306,
-0.024816597,
-0.12198618,
-0.03670733,
-0.001579238,
0.008327494,
-0.007252551,
-0.008154972,
-0.0062870923,
0.036866583,
0.0062472797,
0.028160866,
-0.028877495,
-0.008579642,
-0.009382532,
0.005938731,
-0.011406345,
-0.0050960286,
0.014943042,
-0.0018313852,
-0.032805685,
0.042493448,
0.00497659,
0.023476236,
-0.011824379,
-0.012527737,
0.016986761,
0.01477052,
-0.040396642,
0.007989086,
0.006131159,
0.030178044,
0.009183468,
-0.010424298,
0.037105456,
-0.020516824,
-0.03174401,
0.00020870575,
-0.014783791,
-0.029328706,
0.030735422,
-0.005421166,
-0.021419244,
-0.00012140807,
-0.0026873588,
-0.008062077,
-0.00031020746,
-0.0062008314,
-0.007226009,
-0.009641314,
0.027391152,
-0.030257668,
-0.025931353,
-0.02003907,
-0.038697965,
-0.010610091,
0.00210178,
-0.017464515,
0.0033442688,
0.03625612,
-0.020437198,
0.009256458,
0.0014116928,
0.0050595333,
0.012574185,
0.019508233,
0.012832968,
-0.025612852,
-0.015394253,
-0.032832224,
0.02135289,
-0.01176466,
0.0035997336,
0.026369294,
-0.021286536,
-0.023197547,
-0.025971167,
-0.0017418066,
-0.021605037,
-0.014080433,
-0.0044722958,
-0.041936066,
-0.009269729,
-0.015540233,
0.016402842,
-0.0056169117,
0.02954104,
-0.0045850985,
-0.00025463552,
-0.010119067,
-0.022029707,
0.0043030917,
0.0025314256,
0.0348494,
0.009760752,
-0.009369261,
-0.0128130615,
0.0082810465,
-0.0058226106,
-0.00001704223,
0.019494964,
0.028877495,
-0.0070269457,
-0.038087506,
-0.06184243,
0.012866145,
-0.0018629036,
-0.004107346,
0.013105021,
0.010716258,
-0.021299807,
-0.03538024,
-0.004823975,
0.020729158,
-0.005318316,
0.00753124,
-0.012468018,
0.0021780876,
-0.006914143,
0.0013710506,
0.012049984,
-0.023184275,
0.016946949,
0.032142136,
-0.0163763,
-0.011293543,
0.023184275,
-0.0094157085,
-0.012647175,
-0.007902825,
-0.03293839,
0.023648757,
-0.010702987,
0.008055441,
0.021167098,
-0.033867355,
-0.016522279,
-0.0070402166,
-0.027815823,
-0.019110106,
0.014664353,
0.053587925,
0.012408298,
0.011187375,
0.025201453,
-0.017345076,
0.009409074,
0.0066852197,
-0.0007120671,
-0.0005436925,
-0.025957895,
-0.013974265,
0.013323992,
-0.009482063,
0.020277947,
0.0033492453,
0.009614772,
-0.017902454,
0.0072193737,
0.005597005,
-0.021313077,
-0.011744753,
-0.014385664,
-0.049314693,
-0.020649532,
0.014637811,
0.011963723,
0.00559037,
-0.0014125222,
0.005261915,
-0.019335711,
-0.0011860874,
0.031372424,
-0.045545753,
-0.040396642,
0.007836471,
0.029328706,
-0.01653555,
0.0029146231,
-0.0034006701,
-0.017278722,
-0.018061705,
-0.0013677329,
0.03495557,
0.0047675734,
0.0009190104,
-0.009621408,
-0.010331402,
0.03439819,
-0.0011835991,
-0.008659267,
0.016442655,
-0.0022162416,
0.0045685098,
0.0062738215,
0.010477382,
0.011260365,
-0.008765435,
0.018074976,
0.038087506,
0.025241267,
0.0075179692,
-0.015606587,
0.018924315,
-0.015102292,
-0.0122357765,
0.0014199871,
-0.016429383,
-0.03784863,
0.033283435,
-0.039122634,
-0.020384114,
-0.029726833,
0.00027433454,
-0.01030486,
0.0070269457,
0.011087843,
0.0069738617,
-0.01901721,
0.0045685098,
-0.009999629,
0.00037863557,
-0.018566,
0.020649532,
0.017729932,
0.010384485,
0.021605037,
0.005673313,
-0.0114660645,
0.0069804974,
0.014425476,
-0.01096177,
0.012759978,
-0.0082611395,
0.02529435,
-0.002891399,
-0.025068745,
0.0113798035,
0.003802115,
-0.020941492,
0.031505134,
0.00935599,
0.00891805,
0.09931947,
0.008181514,
-0.043687828,
-0.001081579,
-0.0037258072,
0.017756475,
0.025705747,
0.012474653,
-0.05483539,
-0.01315147,
0.0113798035,
-0.03816713,
0.006671949,
-0.05425147,
-0.021313077,
0.010072619,
-0.0147572495,
-0.0011802814,
0.0027238538,
0.0022461012,
0.016416112,
0.009475428,
0.01338371,
0.028930578,
-0.038140588,
-0.012793154,
0.020357572,
0.0024235996,
-0.009150291,
-0.017039845,
0.0028565628,
-0.010530465,
-0.05133187,
0.0020088835,
0.032832224,
-0.033044558,
-0.011426251,
-0.021193638,
0.0104840165,
0.027762739,
-0.005746303,
-0.016615177,
-0.014160058,
-0.018552728,
0.012501195,
-0.010756071,
-0.026793962,
-0.026064062,
-0.015274814
] |
Longevity is regulated by the daf-2 gene network in Caenorhabditis elegans. Mutations in the daf-2 gene, which encodes a member of the insulin receptor family, confer the life extension (Age) phenotype and the constitutive dauer (a growth-arrested larval form specialized for dispersal) formation phenotype. The Age phenotype is mutually potentiated by two life extension mutations in the daf-2 gene and the clk-1 gene, a homologue of yeast CAT5/COQ7 known to regulate ubiquinone biosynthesis. In this study, we demonstrated that the d
|
[
-0.017127926,
-0.0072260555,
-0.011531807,
-0.036483433,
-0.02140651,
0.012000414,
-0.022316558,
0.016489534,
-0.036266107,
-0.009793207,
0.008903533,
0.013990296,
0.014207621,
0.021148438,
-0.015552319,
-0.010825501,
0.031810943,
0.005052806,
0.020333469,
0.007280387,
-0.015484405,
0.010010532,
-0.005348232,
-0.019627163,
0.011973248,
0.02516895,
-0.009779625,
-0.04789299,
0.0056572407,
0.00012468596,
0.016856268,
-0.0015985271,
-0.0064246696,
-0.0025111223,
-0.0058474005,
-0.011389188,
-0.0013998785,
-0.023267357,
0.02367484,
-0.008835618,
0.02135218,
0.016584612,
-0.0053074835,
-0.0040306994,
-0.0015475915,
0.004557033,
0.0056164926,
-0.024829378,
-0.000041438187,
0.014859595,
-0.00035676104,
0.024095908,
-0.027953425,
-0.0039016625,
-0.007844074,
-0.005541787,
0.011266942,
0.013902008,
0.0017436934,
-0.00550783,
-0.018241717,
0.003348163,
-0.024897294,
0.007266804,
-0.021325015,
0.010845874,
0.0120683275,
0.02874123,
-0.0031121618,
0.014180455,
0.04702369,
0.0363476,
-0.0027335407,
0.010125986,
0.010370476,
-0.013698265,
-0.019015936,
0.022982117,
0.0046249474,
0.0047641713,
0.018907273,
-0.019409837,
-0.0039831595,
0.011620095,
0.013935965,
-0.0075588347,
-0.0145064425,
0.018037973,
-0.015239914,
-0.003497574,
0.011042826,
0.0067336787,
0.007932362,
0.04102009,
-0.017698403,
-0.010261814,
0.023308104,
0.015538736,
-0.018812194,
-0.012346775,
-0.012326402,
0.01405821,
0.01700568,
-0.02237089,
-0.011178654,
-0.0054263333,
0.003894871,
-0.014615105,
0.010451973,
-0.019817322,
0.0015705125,
0.055961184,
0.015728896,
-0.041101586,
0.00719889,
-0.02884989,
0.015497988,
-0.00888995,
0.0074909204,
0.0018336795,
0.017548993,
0.032136932,
0.027002629,
-0.020700205,
0.010010532,
0.022791957,
0.008849202,
0.004112196,
-0.02439473,
-0.008801661,
0.011266942,
0.004332917,
0.020931112,
0.0013107413,
-0.03599445,
0.02376992,
-0.018866524,
-0.014791681,
0.0137186395,
-0.012937628,
0.007864448,
0.02261538,
-0.045339424,
0.0050901584,
-0.009609839,
0.018133054,
0.009100484,
0.019355506,
-0.0011901938,
0.021338597,
0.014900344,
-0.016245043,
0.029637694,
-0.016462367,
0.01883936,
0.03352238,
0.005575744,
0.024856545,
-0.0155115705,
-0.015579484,
0.006995148,
0.0017912332,
0.0002013015,
-0.0023362436,
0.013569228,
0.0181738,
0.016924184,
-0.011205819,
-0.0014380801,
-0.003772626,
-0.015212749,
0.025019538,
-0.007117393,
0.039879136,
-0.008543588,
0.027478028,
0.00090325694,
0.0002627425,
-0.03884684,
-0.0061462224,
-0.009935826,
0.011090365,
0.026500065,
0.030941645,
-0.010506305,
-0.0065774764,
0.010866249,
0.018255299,
-0.00025892234,
-0.00850284,
-0.008550379,
0.002181739,
0.01502259,
-0.00840776,
-0.6306771,
-0.012353567,
0.0013132881,
-0.007857656,
-0.009474011,
0.039688975,
-0.009501177,
0.020700205,
-0.0019032914,
0.03219126,
-0.004696257,
0.010030907,
0.028904222,
-0.008367012,
-0.022411639,
-0.02898572,
-0.0019406442,
-0.029311707,
0.015783226,
0.02961053,
-0.006947608,
0.01836396,
-0.02144726,
0.011511433,
0.0076810797,
0.03352238,
0.01154539,
-0.013935965,
0.014343449,
0.022044903,
-0.017942894,
0.037026744,
-0.009745667,
0.010207483,
0.049196944,
-0.0011231287,
0.0044857236,
0.0065503106,
0.01661178,
0.046833534,
-0.020469297,
0.008638668,
0.028442407,
0.0067574484,
-0.03574996,
-0.02150159,
0.0014525119,
0.022194313,
0.009494385,
-0.014995424,
0.005297296,
0.013209284,
-0.021854743,
-0.01628579,
0.005850796,
0.012958002,
0.016557448,
-0.023688423,
0.028197916,
-0.00032662417,
0.0034839911,
0.03971614,
-0.0040952177,
0.0054568946,
-0.014071792,
0.008149687,
-0.0033787242,
0.025141783,
-0.0030221755,
0.003633402,
0.018010808,
0.019722242,
-0.00635336,
0.020849615,
0.024435477,
0.013440192,
0.0071445587,
0.009827164,
-0.0038914755,
0.031023141,
-0.010805126,
-0.020808866,
-0.031077472,
0.010125986,
0.034201518,
-0.025250446,
-0.030452663,
0.0038711012,
-0.024761464,
-0.001132467,
0.031620786,
-0.0013336623,
-0.025291195,
-0.019056685,
-0.008706582,
0.01589189,
-0.013514897,
0.008380595,
0.0009669264,
-0.033495214,
-0.006190366,
0.005276922,
-0.006102078,
-0.0035790708,
0.025725845,
0.019599997,
-0.030181007,
0.018078722,
0.029583363,
-0.023416767,
-0.009569091,
0.0033006233,
-0.013134578,
-0.027002629,
-0.007484129,
-0.02057796,
0.019002354,
0.00027844764,
0.010492722,
-0.020170474,
-0.0026248782,
-0.0012767842,
0.0042955643,
-0.015416491,
0.005117324,
0.024000827,
-0.014316283,
-0.014669436,
-0.008692999,
-0.018133054,
0.01725017,
0.016054884,
0.007952736,
-0.022004154,
0.021773247,
-0.0011910428,
0.019396255,
0.0041088006,
0.02898572,
-0.007518086,
-0.019178929,
-0.0034177748,
0.0026809075,
-0.0037997914,
-0.014628688,
-0.0051818425,
-0.009358557,
0.0019966732,
0.0071513504,
0.006149618,
0.0064620227,
0.013725431,
-0.016312957,
0.011056408,
-0.0032479898,
-0.016217876,
-0.008625085,
-0.01676119,
-0.023321686,
-0.014791681,
0.0037420646,
0.0016239949,
-0.032870404,
-0.006526541,
-0.023756336,
0.0023634091,
0.023783503,
0.016883435,
-0.022044903,
-0.026798887,
-0.019206095,
-0.013474149,
-0.011654052,
0.008747331,
0.013379069,
0.024435477,
-0.016245043,
-0.004034095,
-0.007260013,
-0.01449286,
0.015905472,
-0.0107779605,
-0.015932638,
-0.022778375,
0.03941732,
0.004529868,
0.010058071,
0.020523628,
-0.0036164236,
0.038738176,
-0.016462367,
-0.0013693172,
-0.014628688,
0.02507387,
-0.0075248773,
-0.013657517,
0.024231736,
-0.014968258,
0.0068627154,
0.014329866,
0.012326402,
-0.030995976,
0.013562437,
-0.016503116,
0.0105606355,
-0.024557723,
0.018961605,
-0.013032707,
0.0054433118,
0.01609563,
-0.015239914,
0.0101939,
-0.007715037,
0.0037386687,
0.015253497,
0.004006929,
-0.0108866235,
-0.0036401935,
-0.011103949,
0.0022683295,
-0.0043838522,
-0.010479139,
0.0063703386,
-0.0119325,
0.012489395,
0.028197916,
0.006499375,
0.025250446,
0.0037013162,
-0.02328094,
-0.018689949,
0.003599445,
-0.0023820857,
0.020523628,
-0.0047777537,
0.011368813,
0.0022581425,
-0.010852667,
0.04876229,
0.0004953481,
0.027722519,
-0.000982207,
0.027695352,
0.003986555,
-0.010866249,
-0.0047573796,
0.022425221,
0.023416767,
-0.030995976,
-0.006227719,
-0.006750657,
0.041807894,
-0.008400969,
-0.00274203,
-0.014981841,
0.015674565,
0.008136104,
0.013671099,
0.024666386,
0.01893444,
0.027328616,
0.0075248773,
-0.026092581,
-0.020659456,
0.005185238,
0.013243241,
0.010696464,
-0.014615105,
-0.007382258,
-0.011334856,
-0.023117945,
0.004550242,
0.0083398465,
-0.020496462,
0.034826327,
0.0052022166,
0.015239914,
0.015769644,
0.014017462,
0.0037454602,
0.0049169776,
-0.034120023,
0.037189737,
0.025481354,
-0.011762715,
-0.029963681,
-0.019640746,
0.0038643098,
0.0039050584,
0.0027284473,
-0.0010212576,
0.01101566,
0.0011392583,
-0.0013353601,
-0.0021579692,
0.004859251,
0.015579484,
-0.038683847,
0.00057217595,
-0.0108119175,
0.009168398,
0.009175189,
0.018187385,
-0.009779625,
0.022846289,
-0.015063338,
0.0032395006,
-0.009188772,
0.008577545,
-0.019681493,
0.0052022166,
-0.00797311,
0.015525154,
-0.024910877,
-0.0012182083,
-0.0043464997,
-0.0040035336,
-0.0065978505,
0.00821081,
-0.005494247,
-0.005198821,
-0.0372169,
-0.016625362,
-0.005986624,
0.025250446,
0.018676365,
0.0061190566,
-0.00021159473,
0.006818571,
0.00029203045,
0.0029474702,
-0.0003221673,
0.024516974,
0.0028269226,
-0.022343725,
-0.011151488,
0.02507387,
-0.020265555,
0.022139983,
0.013779762,
0.0034364513,
-0.023905749,
-0.009141232,
0.0046249474,
0.0032717597,
-0.013990296,
0.031376295,
0.04523076,
0.03588579,
-0.0073754666,
0.0018897087,
0.033739705,
0.0010713442,
-0.010689673,
0.011036035,
0.008027442,
0.017576158,
0.043926813,
0.0055961185,
-0.007518086,
0.006917047,
0.034907825,
0.015728896,
0.00018984101,
0.01638087,
-0.0071513504,
0.0023718984,
-0.014044627,
0.009188772,
-0.018268881,
-0.019450586,
0.024326814,
-0.018961605,
-0.013134578,
0.034283016,
-0.022153566,
-0.032734577,
-0.021623835,
0.028225083,
-0.003507761,
-0.010608176,
-0.010234648,
-0.008713374,
-0.01275426,
-0.0022632359,
-0.01860845,
0.031131804,
0.0007759181,
-0.008835618,
-0.006502771,
-0.0071920985,
-0.016394453,
-0.020075396,
-0.008509631,
0.0051920298,
-0.028062088,
-0.014452111,
0.005660637,
0.0017810462,
0.018907273,
0.022099234,
-0.019341923,
0.004706444,
0.01502259,
-0.0015025985,
-0.0030663197,
-0.010200691,
-0.03338655,
0.0053210664,
0.0073075527,
0.016448785,
-0.029882185,
-0.0067676357,
-0.0046113646,
0.016109215,
-0.0073075527,
0.029501867,
0.0017691612,
-0.026133329,
-0.007796534,
0.027138457,
0.02971919,
-0.004706444,
-0.009358557,
0.011735549,
-0.024136655,
-0.040259454,
0.0069611906,
-0.014791681,
-0.023022866,
0.00830589,
-0.0031172552,
-0.013243241,
-0.009080109,
0.0031512124,
-0.0023345456,
-0.0033515587,
-0.0031698886,
0.017576158,
0.03132196,
-0.0059288973,
-0.0082651405,
-0.016937766,
0.006750657,
0.002433021,
-0.0033770264,
0.039553147,
0.008957864,
-0.01719584,
0.03178378,
-0.009141232,
-0.0018897087,
-0.017127926,
0.011103949,
0.0076810797,
0.024652803,
-0.0076878713,
-0.04914261,
-0.021718916,
0.0042106714,
-0.020591542,
0.00078228506,
0.0011672728,
-0.005463686,
-0.023403184,
-0.013433401,
0.013229658,
-0.020931112,
0.029529031,
-0.038520854,
-0.019206095,
0.0008811849,
0.022941368,
0.010207483,
-0.0032547812,
0.00096013496,
-0.006115661,
0.007701454,
-0.022411639,
-0.025386274,
0.019043101,
-0.020469297,
0.034609005,
0.024435477,
0.0259975,
0.0013463962,
0.015375743,
0.041427575,
0.022927785,
0.004013721,
-0.006434857,
0.013535271,
-0.012638806,
0.017277336,
0.0020374218,
-0.00089646556,
0.01589189,
-0.02178683,
0.022357307,
0.021189185,
0.0026571376,
-0.037325565,
-0.0008905231,
-0.06856603,
-0.024747882,
0.01613638,
-0.027029794,
-0.014941093,
-0.018268881,
0.0033192995,
0.0111718625,
0.024516974,
-0.008604711,
-0.008224392,
0.028605402,
-0.021718916,
0.03444601,
-0.0028778582,
-0.00096947316,
-0.03197394,
-0.015389325,
0.0074365893,
0.006502771,
0.0132160755,
-0.014329866,
0.020876782,
-0.0022819124,
-0.013161744,
0.022710461,
-0.010859458,
-0.0129647935,
-0.0251282,
-0.020876782,
-0.022235062,
-0.00040154185,
-0.027600273,
-0.03232709,
-0.03463617,
0.006010394,
0.011857795,
-0.027301451,
0.03661926,
-0.006363547,
-0.035668463,
0.014275535,
-0.0003748007,
0.009338182,
-0.023702005,
0.02724712,
0.019015936,
0.02218073,
-0.012326402,
-0.019070268,
0.030860148,
-0.00473361,
0.021216352,
0.031512123,
-0.00676424,
-0.014370615,
0.012414689,
0.009297434,
-0.022601798,
-0.038330693,
0.014574356,
-0.031620786,
0.02709771,
0.00233115,
0.0024941438,
-0.0032530832,
-0.01840471,
-0.020768119,
0.0009813581,
-0.0018693344,
-0.010166734,
0.0020645873,
0.0057285507,
-0.008631877,
0.013922381,
0.008292306,
-0.01560665,
-0.0095623,
-0.01458794,
0.0073075527,
0.0015009006,
-0.0043498953,
0.0407756,
0.0073075527,
0.009358557,
-0.011776297,
0.0016723836,
-0.005310879,
0.005422937,
-0.00879487,
0.040666938,
-0.022139983,
-0.012958002,
-0.0033209973,
-0.009433262,
-0.013345112,
0.008706582,
-0.0114231445,
-0.0045875944,
-0.023742754,
-0.013365487,
0.016299374,
0.006193762,
-0.0076063746,
0.013786553,
-0.023131527,
-0.013793345,
-0.0048524593,
-0.03265308,
0.029963681,
-0.03053416,
0.011830629,
-0.010064864,
0.008156478,
0.006706513,
0.017657654,
0.00038435112,
-0.013243241,
0.026350655,
-0.026092581,
0.027844762,
-0.0105606355,
-0.030479828,
-0.009766041,
0.01923326,
-0.020021064,
-0.019097432,
0.012149825,
0.0034126814,
-0.02348468,
-0.022601798,
-0.018133054,
0.012665971,
0.027790433,
-0.020931112,
-0.014452111,
0.009935826,
0.029040052,
-0.005290505,
-0.019749409,
0.012407898,
-0.0089850295,
0.01893444,
0.0007003637,
-0.008475674,
0.00461476,
0.0025569643,
-0.010092028,
-0.002215696,
0.0067812186,
-0.022479553,
-0.0037624387,
0.0071853073,
-0.0064280657,
0.012285653,
-0.019002354,
-0.025617182,
-0.027111292,
0.02420457,
-0.017847814,
0.0022123004,
-0.009073318,
-0.010037698,
-0.00753846,
0.01889369,
-0.0069272337,
0.00678801,
-0.003772626,
-0.026839634,
-0.034038525,
-0.008102147,
-0.026269156,
0.025875255,
0.028279413,
-0.0075045032,
-0.022248644,
-0.008108938,
-0.017698403,
-0.024788631,
0.010261814,
0.01034331,
-0.0064042956,
0.013637142,
0.0010450275,
0.027899094,
-0.008530006,
0.026323488,
-0.0085164225,
-0.004278586,
-0.007015522,
-0.006275259,
0.021691749,
0.0063058203,
-0.017562576,
-0.01893444,
0.012903671,
-0.008190435,
-0.027233537,
-0.0046351342,
-0.021270683,
0.011531807,
0.0014211016,
-0.0042480244,
-0.0029389807,
0.0053652106,
0.0001296734,
-0.011558972,
0.0028201311,
-0.007572417,
-0.014003878,
-0.013365487,
-0.01932834,
-0.0053516277,
-0.0012572589,
0.006937421,
-0.010302562,
-0.019450586,
0.0028761602,
0.00042700963,
0.019627163,
0.028714063,
0.00830589,
0.008007067,
0.019898819,
-0.008964656,
-0.02879556,
-0.018567704,
-0.009480802,
-0.014357031,
-0.010499513,
0.006343173,
0.01763049,
-0.0147237675,
0.008665834,
-0.036266107,
-0.006071517,
-0.0026197848,
-0.014805265,
-0.0355598,
0.0329519,
0.017399581,
0.010961329,
-0.012842548,
0.0001836863,
-0.00064730586,
-0.016163545,
0.004730214,
-0.0073415097,
0.0068491325,
-0.01923326,
0.01787498,
-0.013535271,
0.008896741,
-0.0372984,
-0.019803738,
0.0050358274,
0.016190711,
0.18929006,
-0.009283852,
-0.009684544,
0.0026758139,
0.012543727,
0.0020187453,
0.030344,
-0.013127787,
-0.010934163,
0.0072260555,
-0.016462367,
0.009338182,
-0.00019673853,
-0.0024194382,
0.013127787,
-0.013514897,
-0.008828827,
0.020659456,
-0.012747468,
0.00012065357,
0.023457516,
-0.021759665,
0.010852667,
-0.011178654,
0.051804844,
0.0023820857,
-0.036646426,
-0.007287178,
0.0028880453,
0.0025552665,
-0.020306302,
-0.013562437,
0.005653845,
0.012536935,
-0.018445458,
0.0048898123,
-0.0064280657,
-0.013209284,
0.015158418,
-0.009929035,
0.008448509,
0.013908799,
-0.0010153152,
-0.0015739083,
0.009412888,
0.011273733,
-0.0008064794,
-0.035940118,
-0.017019263,
-0.0017572762,
-0.061665963,
0.003188565,
0.018486205,
0.028931389,
-0.008686208,
-0.015959803,
0.016272208,
0.00017509093,
0.00019546514,
0.011409561,
-0.01860845,
0.010445182,
-0.042052384,
0.0039933464,
-0.013127787,
0.03526098,
-0.027124874,
0.022683294,
0.02382425,
-0.029257376,
-0.02971919,
-0.022139983,
-0.004105405,
0.021515174,
-0.0056979894,
-0.004057865,
0.011328065,
0.027464444,
0.022846289,
0.0083398465,
0.0031257444,
-0.0060273726,
-0.026758138,
-0.0018370752,
-0.0034907826,
-0.04183506,
0.037189737,
0.0052022166,
-0.030018013,
-0.02550852,
0.023661258,
-0.031104637,
-0.0055315997,
0.0026724183,
0.009440054,
-0.00816327,
0.006241302,
0.040422447,
0.0068593198,
-0.01657103,
-0.019776573,
0.057862777,
0.016245043,
0.012401107,
-0.013209284,
0.008380595,
-0.015253497,
0.035369642,
0.004730214,
-0.022873454,
-0.0019151764,
-0.024462644,
0.005494247,
-0.012890088,
-0.009766041,
0.000079905134,
-0.006115661,
-0.02131143,
0.024598472,
-0.031865276,
-0.01806514,
-0.03846652,
-0.025549268,
0.043655157,
-0.008815245,
-0.014411363,
-0.032408588,
-0.02265613,
-0.023756336,
-0.037896045,
0.0059696455,
-0.011830629,
-0.0022089046,
0.018961605,
0.008421343,
-0.007959528,
0.00036758484,
-0.019409837,
-0.019219678,
0.019165346,
-0.022167148,
-0.028388076,
0.019015936,
-0.011165071,
-0.009426471,
-0.027382948,
0.016340122,
0.013508106,
-0.007511295,
0.005996811,
-0.0105266785,
-0.02541344,
0.010159943,
0.0035790708,
0.004811711,
-0.014778099,
-0.022873454,
-0.029936517,
0.007878031,
0.0028082463,
-0.028523903,
-0.00004332174,
0.014289117,
0.014520026,
-0.0018523559,
0.010227857,
-0.17320801,
0.004309147,
-0.00003642422,
-0.017535409,
0.01700568,
0.0087677045,
0.032299925,
-0.0062718634,
-0.0046792785,
0.035777126,
0.020591542,
-0.0018455645,
-0.047322515,
-0.031756613,
0.010180317,
0.022506718,
-0.038357858,
0.028170751,
0.011090365,
-0.003599445,
0.037407063,
-0.03493499,
0.03096881,
-0.013698265,
-0.014139706,
0.014166872,
0.027179206,
-0.028659731,
0.0025909212,
-0.022533884,
-0.0407756,
0.017182257,
0.02966486,
-0.0039695767,
-0.005534996,
-0.01096812,
-0.019206095,
0.011776297,
-0.0016638944,
0.0073890495,
0.015783226,
0.04300318,
-0.0010322937,
0.0023192652,
-0.01270672,
0.03259875,
0.0038099785,
0.00043401326,
0.016788354,
-0.022547467,
0.036021616,
-0.003130838,
0.012333193,
0.017603323,
0.020605125,
0.0037862086,
-0.009650587,
0.014615105,
-0.008543588,
-0.0058304216,
-0.0093449745,
0.0016868154,
0.037434228,
-0.0024432081,
0.012489395,
-0.027899094,
-0.03759722,
0.002893139,
-0.012013997,
0.006604642,
-0.0032395006,
0.00096947316,
0.012591266,
-0.00985433,
0.0320826,
0.015375743,
-0.01183742,
-0.009338182,
-0.0011239776,
-0.015036172,
-0.012958002,
0.028442407,
-0.021623835,
-0.01628579,
-0.02163742,
-0.0017640677,
0.01970866,
0.038439356,
0.005290505,
-0.009575882,
0.018852942,
-0.013976713,
-0.005681011,
-0.013949547,
0.01439778,
0.017521827,
-0.0024550932,
-0.006492584,
0.01893444,
0.0011222798,
0.009446845,
-0.022153566,
-0.013603185,
-0.0037352731,
0.015144834,
-0.014031044,
-0.030425498,
0.0068864855,
0.0372169,
0.005619888,
0.019735824,
0.025983918,
0.011260151,
0.018472623,
-0.005209008,
0.009392514,
-0.0150090065,
-0.019790156,
0.012862923,
-0.012584475,
0.051777676,
0.020999026,
0.0021409907,
0.016258625,
-0.010397642,
-0.02637782,
-0.11029243,
-0.023376018,
0.015932638,
0.030425498,
-0.015172,
0.007518086,
0.006947608,
0.02830658,
-0.030126676,
0.024775049,
-0.018526955,
-0.010390851,
0.009535134,
0.0073618838,
0.014655854,
-0.01849979,
0.02787193,
-0.012727094,
-0.016638944,
0.03406569,
-0.012115868,
-0.010404433,
0.015919056,
-0.0037284817,
-0.0072192643,
-0.0013956339,
-0.032625914,
0.008353429,
-0.007035896,
0.02633707,
-0.0012818779,
0.0020951487,
0.009412888,
0.0007784649,
-0.024571305,
-0.033929862,
0.004305751,
-0.012924045,
0.054602902,
-0.030235339,
-0.004339708,
0.013806928,
0.007266804,
0.003015384,
0.01188496,
-0.0013387558,
0.014764516,
0.012109077,
-0.005361815,
-0.033060562,
-0.031539287,
-0.0055791396,
-0.031620786,
-0.003517948,
0.01647595,
-0.041346077,
0.02120277,
0.020700205,
0.009494385,
0.0054806643,
0.020401383,
0.019912401,
-0.025223281,
-0.004265003,
0.015104086,
-0.017942894,
-0.034799162,
-0.032435752,
0.015389325,
-0.015674565,
0.020333469,
-0.0055146213,
-0.0033311844,
-0.011952874,
-0.042188212,
0.0064857923,
-0.002548475,
-0.023443932,
0.0035451138,
-0.02237089,
-0.0043804566,
-0.009820373,
0.018431876,
-0.04286735,
0.034418844,
0.0021936242,
0.017603323,
-0.007484129,
0.024245318,
-0.01700568,
-0.010390851,
0.026649475,
0.005117324,
0.0067472616,
-0.0256036,
0.011178654,
0.0007266804,
0.0030221755,
0.022235062,
0.010642133,
-0.04585557,
-0.01763049,
-0.06498017,
0.0067676357,
0.0052259867,
-0.013195701,
0.0030714131,
-0.021691749,
0.0097728325,
-0.0016367288,
-0.01072363,
0.01067609,
-0.007619957,
0.014357031,
-0.0060036024,
-0.009840746,
-0.015593068,
-0.01830963,
0.02884989,
-0.005158073,
0.037189737,
0.031675115,
0.00893749,
0.012088702,
0.007701454,
0.0010331426,
-0.016584612,
0.0123196095,
-0.018010808,
0.0030238733,
-0.007164933,
0.011239776,
0.00081793993,
-0.040721267,
0.0071581416,
0.009820373,
-0.010037698,
-0.025440605,
0.00031771045,
0.029012885,
0.016353704,
0.014275535,
0.002777685,
-0.027668187,
0.016598195,
-0.025359109,
0.010839083,
-0.018567704,
-0.04096576,
0.0033413717,
0.016924184,
-0.0062073446,
0.014465694,
-0.0015441959,
0.0015594765,
-0.015525154,
-0.00024788632,
-0.0024958416,
0.0005993415,
-0.020958278,
-0.013358695,
-0.027518775,
0.027545942,
-0.007782951,
0.021922657,
-0.0077218283,
0.009827164,
-0.035097986,
-0.040177956,
-0.016272208,
0.0035960493,
-0.03314206,
-0.0035349266,
0.0068525285,
0.033332217,
-0.003942411,
0.010003741,
-0.004604573,
-0.022248644,
-0.01719584,
-0.016312957,
0.008013858,
0.008122521,
0.0027301451,
-0.009141232,
0.00971171,
0.012469021,
0.016312957,
-0.0076946625,
-0.0028982323,
0.011844211,
0.0037658345,
-0.013650726,
0.018852942,
-0.00040536202,
0.000822609,
0.011592929,
0.0049984744,
-0.004091822,
0.0042683985,
-0.0071445587,
0.021121271,
-0.016679693,
0.017929312,
-0.003517948,
-0.016489534,
-0.009453637,
0.034989323,
-0.019627163,
-0.038276363,
-0.0052803177,
0.009514759,
0.00816327,
0.017413164,
0.0044619534,
0.0068423413,
0.002889743,
0.006866111,
-0.005952667,
-0.010221066,
-0.006910255,
0.0088424105,
0.027600273,
0.014750933,
-0.0061665964,
-0.012204156,
0.0022734231,
0.014248369,
0.018146636,
-0.012475812,
0.007586,
-0.012530143,
0.015647398,
-0.0005870321,
-0.02072737,
-0.025223281,
-0.0072532212,
-0.01560665,
0.019355506,
0.0098814955,
-0.03871101,
0.09844822,
0.034228686,
-0.036646426,
0.0177799,
-0.01473735,
0.017046427,
-0.021732498,
0.0037352731,
-0.017657654,
-0.027478028,
0.010839083,
-0.033929862,
0.014968258,
-0.022927785,
0.00470984,
0.024761464,
-0.010662507,
0.0062990286,
-0.013834094,
-0.029447535,
0.011491058,
0.0019712055,
-0.0031342336,
0.025617182,
-0.017318085,
0.0064518354,
0.038194865,
0.0035383224,
0.013446983,
-0.025712263,
0.008862784,
-0.0147237675,
-0.0195185,
0.015212749,
0.018594868,
0.0027573106,
0.0017318084,
-0.012958002,
0.013120996,
0.01130769,
-0.020116143,
-0.01212945,
-0.004047678,
-0.019097432,
0.02135218,
0.0018031182,
-0.0058779614,
-0.012917253,
-0.008957864
] |
Brown fat is a specialized fat depot that can increase energy expenditure and produce heat. After the recent discovery of the presence of active brown fat in human adults and novel transcription factors controlling brown adipocyte differentiation, the field of the study of brown fat has gained great interest and is rapidly growing. Brown fat expansion and/or activation results in increased energy expenditure and a negative energy balance in mice and limits weight gain. Brown fat is also able to utilize blood glucose and lipid and results in improved glucose metabolism and blood lipid independent of weight loss. Prolonged cold exposure and beta adrenergic agonists can induce browning of white adipose tissue
|
[
-0.0089569455,
-0.03082492,
0.0063350033,
-0.026786152,
-0.029313639,
-0.009230539,
-0.023020979,
-0.015086753,
-0.017444873,
-0.0066574533,
-0.0062014633,
0.013562444,
-0.0031333023,
0.009093743,
-0.024701627,
-0.0032245005,
0.0485955,
0.0034590093,
-0.0055239927,
-0.0110284425,
-0.02923547,
0.014318084,
-0.019672709,
-0.008071022,
-0.006510885,
-0.010539882,
0.021626951,
-0.03819893,
-0.007712744,
-0.022030829,
0.031632673,
-0.0063350033,
-0.012585322,
0.0014379969,
0.002384176,
-0.0027896813,
-0.015425488,
-0.016506836,
0.016832544,
-0.025600579,
0.029339695,
0.014083575,
-0.009810298,
0.021001594,
-0.0050549745,
-0.0064946,
0.009178426,
-0.019464256,
-0.006957104,
0.028792508,
-0.008018909,
0.024897052,
-0.0053350823,
-0.0017001911,
-0.026251992,
0.005227599,
0.0043286476,
0.026160795,
0.0032521854,
-0.022108998,
0.00052683125,
-0.00033140698,
-0.01866953,
0.00045598994,
0.018513191,
-0.0011619601,
-0.0025258586,
0.019646652,
0.009992694,
0.0016953055,
0.002265293,
0.012709091,
0.004957262,
0.014839216,
0.021926602,
-0.0060288385,
-0.01739276,
0.019477285,
0.0044133314,
-0.01146489,
0.027124887,
-0.031137599,
-0.011289008,
0.051592007,
0.01572514,
0.0071655563,
-0.024428032,
0.0012401298,
-0.031398166,
-0.006279633,
0.0045696707,
-0.003667462,
0.035645384,
0.022447733,
-0.003442724,
0.00085416686,
0.004357961,
0.026994605,
-0.015881479,
-0.0080645075,
-0.00824039,
0.016871627,
-0.022734355,
-0.013178109,
-0.033534802,
0.016415639,
-0.012259616,
-0.008859233,
0.01997236,
-0.009595332,
-0.01184271,
0.037078496,
0.0055728485,
-0.051201157,
-0.0032928989,
0.0259784,
-0.0034622666,
-0.015816336,
-0.008611696,
-0.012305214,
0.019724822,
0.027619962,
-0.014005406,
0.010259774,
0.0039605983,
-0.009530189,
0.01119781,
-0.0032017007,
-0.011249923,
-0.005413252,
-0.013471246,
-0.021822376,
0.010311887,
0.016155072,
-0.039892606,
0.026538614,
-0.015503658,
-0.011803625,
-0.013223709,
-0.014721961,
-0.004038768,
0.02134033,
-0.020923425,
-0.0046576117,
-0.012683035,
0.050367348,
0.015777253,
0.0042569917,
-0.008292503,
0.0048400075,
-0.0025226015,
0.00020712936,
0.029782658,
0.005006118,
0.0060255816,
0.0036804902,
0.013849067,
0.014448367,
-0.035046086,
-0.013731811,
0.02892279,
-0.0055142213,
0.009217511,
0.014552593,
0.005690103,
0.011777569,
-0.011126155,
-0.027463622,
0.02649953,
-0.017523043,
0.023125205,
0.018083258,
-0.018617418,
0.041925017,
-0.012819831,
0.02664284,
-0.0175491,
0.0021692093,
-0.0064783143,
-0.0015405946,
0.007693202,
0.001581308,
0.011758027,
0.000033715776,
-0.0037358606,
-0.0012100019,
0.02057166,
-0.024844939,
0.024571344,
-0.027229114,
-0.0052080564,
0.022382593,
0.0002764439,
-0.0028417944,
-0.6474536,
0.004116938,
0.016884657,
-0.016598035,
-0.0057422165,
0.023880845,
0.009947095,
0.0008004252,
-0.011471405,
0.0012124447,
0.004439388,
0.013731811,
0.009048143,
-0.021952659,
0.016376553,
-0.021848433,
-0.023112176,
-0.009165398,
-0.0014697533,
-0.013536387,
-0.016624091,
0.016754374,
-0.03267494,
0.021157933,
0.024649514,
0.018317768,
0.0076410887,
0.0012482725,
0.0072762966,
0.025926286,
0.0059246123,
0.02960026,
0.017366704,
0.010937245,
0.06368225,
0.0018663018,
0.0004083553,
0.028297434,
0.0020291551,
0.025717832,
-0.011451862,
-0.0048465217,
0.020845255,
-0.0118687665,
-0.026395304,
0.0149043575,
-0.007966796,
0.023333658,
0.00854004,
-0.01138672,
0.0095106475,
-0.0031463306,
-0.009693043,
-0.018539248,
0.016181128,
-0.006644425,
0.013432161,
-0.003323841,
-0.005592391,
0.024649514,
0.004498015,
0.02582206,
-0.009145856,
-0.015164923,
-0.030434072,
0.021887517,
-0.048491273,
0.0022571501,
0.010012236,
-0.013106454,
0.010611538,
0.02292978,
-0.016910713,
0.011972994,
0.026108682,
-0.0059702112,
0.017979031,
0.008383701,
-0.010155547,
-0.005634733,
0.0035567216,
0.01929489,
-0.01898221,
0.0009787498,
0.026382275,
0.0015699082,
0.0066248826,
0.000054454158,
-0.0016839057,
-0.001316671,
0.0034655237,
-0.0048237224,
-0.025704805,
-0.022043858,
-0.021522725,
0.017184306,
0.010728792,
-0.0043742466,
0.0032131006,
0.012533209,
-0.022630129,
0.0036609478,
-0.009582303,
-0.013119482,
0.021692093,
0.00181256,
-0.0031561018,
0.0004710539,
0.03728695,
-0.040075,
0.007556405,
-0.008181763,
0.00053660246,
0.018474108,
-0.009842869,
-0.017874805,
0.01929489,
-0.024024157,
0.0016024789,
-0.014852244,
0.032935504,
0.0027587393,
0.006878934,
-0.011210838,
0.02346394,
0.018187486,
-0.0022294652,
-0.020714972,
-0.027698133,
-0.027281227,
-0.0045696707,
0.011588659,
0.025470296,
-0.00968653,
0.030538298,
0.017731495,
0.0029329925,
-0.0068724197,
0.014044491,
-0.02110582,
-0.021223076,
-0.013484274,
0.01715825,
-0.010012236,
-0.013432161,
0.000836253,
-0.0134582175,
0.005530507,
0.013132511,
0.009823326,
-0.018083258,
-0.0024949163,
-0.028193207,
0.002503059,
0.036036234,
-0.010624566,
-0.00021618808,
-0.024766767,
0.008344616,
0.0057357023,
-0.017067052,
0.01693677,
0.01420083,
0.036114402,
-0.024480145,
-0.02231745,
-0.01997236,
0.011569116,
-0.016050845,
-0.028375603,
-0.0013182996,
-0.020376237,
-0.0041039097,
0.006009296,
-0.0014762675,
-0.0039573414,
-0.008709408,
-0.021418499,
-0.025483323,
0.00032000724,
-0.0067747077,
0.013966321,
-0.021457585,
0.008533526,
0.045963787,
0.010318401,
0.0012287301,
-0.0024004614,
-0.0060776947,
-0.0035469504,
-0.014344141,
0.025105504,
-0.008969974,
-0.0039345417,
0.019855104,
-0.046875767,
0.020871311,
0.008018909,
0.014044491,
0.011236895,
0.0047944086,
-0.031163655,
0.031632673,
-0.014187802,
0.021457585,
-0.040413737,
0.0037651742,
-0.019933274,
0.019060379,
-0.01633747,
-0.02217414,
0.016298383,
0.017666353,
-0.018239599,
0.01700191,
0.021600895,
-0.014005406,
-0.010767877,
0.012383384,
-0.02824532,
0.011933908,
-0.010878617,
0.0042048786,
-0.010969815,
-0.03129394,
0.011758027,
0.024284722,
0.007751829,
-0.00012773825,
0.001201045,
0.015308234,
0.01936003,
-0.013562444,
0.018096287,
-0.008285989,
-0.028610112,
0.0026317134,
-0.016350497,
0.016519865,
0.03728695,
0.012324757,
-0.0012490867,
0.019021295,
-0.01563394,
0.005081031,
-0.008194791,
-0.0073218956,
0.009666987,
-0.0119404225,
0.01055291,
-0.009132828,
0.008644267,
-0.008468385,
0.015699083,
0.014982527,
-0.0033108126,
0.03554116,
-0.0040615676,
0.03158056,
0.025991427,
0.02513156,
0.00058016577,
-0.022617102,
-0.018200513,
0.011933908,
0.010891645,
0.010083892,
-0.013927236,
-0.002745711,
0.0041299663,
-0.034368612,
-0.0013638985,
-0.0042960765,
-0.04828282,
0.034863688,
0.019855104,
0.015581828,
0.015099782,
0.019529399,
0.010539882,
0.0017816179,
-0.025522409,
0.022955837,
0.017262477,
-0.010246745,
-0.012702577,
-0.019672709,
-0.0006107008,
-0.010122977,
0.0091002565,
-0.0031561018,
-0.0029965055,
-0.02550938,
-0.0018532735,
-0.018330796,
-0.010891645,
0.018461078,
-0.020545604,
0.034342557,
-0.008071022,
0.024701627,
0.008442328,
-0.011477918,
-0.009960123,
0.039163023,
0.01981602,
0.010324915,
0.016415639,
0.012481096,
-0.001523495,
-0.040908813,
-0.011347636,
0.016598035,
-0.0007918754,
0.01081999,
0.012780746,
0.0012678149,
-0.0014884814,
0.02066286,
0.007960281,
-0.008233876,
-0.03363903,
-0.01708008,
-0.014005406,
0.049715932,
0.032857332,
-0.0069701322,
0.004905149,
0.011784083,
-0.0030453615,
-0.007953768,
-0.003439467,
0.011302036,
-0.0042048786,
0.017171279,
0.0033140697,
-0.013471246,
-0.0029916198,
-0.018630447,
-0.0071329856,
0.0045696707,
-0.03645314,
-0.010702736,
-0.015594856,
0.012103276,
0.0031072458,
0.01731459,
0.02536607,
0.037391175,
0.026408331,
0.0042374493,
0.02057166,
-0.015451545,
-0.009666987,
-0.006748651,
0.00046535404,
-0.005628219,
0.00941945,
-0.0027049975,
-0.016102958,
-0.003976884,
0.0037782025,
0.010872103,
-0.0012670007,
0.016624091,
0.030616468,
0.014226886,
0.0069440757,
0.013523359,
-0.017379731,
-0.0151909795,
0.010298858,
0.0011912737,
-0.018877983,
0.036036234,
-0.010481254,
-0.022669215,
-0.01723642,
0.014461395,
-0.010663651,
0.016558949,
-0.0129892,
0.01563394,
-0.01777058,
-0.00035787068,
-0.01723642,
0.019164607,
-0.004393789,
-0.0008215962,
-0.0049149203,
0.0155297145,
-0.013445189,
-0.011992536,
0.022161111,
0.012070705,
-0.017132193,
-0.012630922,
0.0019167863,
0.010461712,
0.020011444,
0.00033120342,
-0.039136965,
0.020154756,
0.0015283806,
0.00052927405,
-0.0126178935,
0.010806962,
-0.035124253,
0.029548148,
-0.021405471,
0.034655236,
-0.047865916,
-0.024988249,
-0.007302353,
0.001255601,
-0.017210364,
0.024193523,
-0.008976487,
-0.015568799,
0.014331113,
0.005605419,
0.00880712,
0.020206869,
-0.03288339,
-0.0034524952,
0.022604072,
-0.012624407,
-0.004045282,
-0.007960281,
0.0120641915,
0.005172229,
-0.013653642,
-0.008657295,
-0.011191296,
0.010181604,
0.0010422628,
0.009347794,
-0.007569433,
0.036348913,
0.017627269,
0.011888309,
0.02923547,
0.0014371827,
-0.0066704815,
-0.014643791,
-0.035046086,
0.028219264,
-0.002286464,
-0.008318559,
-0.0150476685,
-0.009732128,
0.0075889756,
-0.03447284,
0.006637911,
-0.020389264,
0.0055728485,
-0.01321068,
-0.026395304,
-0.062744215,
0.009054657,
-0.009966637,
0.015985705,
-0.032153804,
0.012148875,
-0.024727684,
0.00596044,
0.019425172,
-0.0105463965,
0.053780757,
-0.02816715,
-0.007015731,
0.014435339,
0.016545922,
0.023307601,
0.0057943296,
-0.013836037,
-0.009992694,
-0.008755007,
0.0161681,
-0.018591361,
0.011705914,
-0.0077322866,
0.04070036,
0.027567849,
0.025313957,
0.013796953,
0.0012946858,
0.027177,
0.0004118159,
0.012715605,
-0.007243726,
0.01594662,
0.0012148875,
0.008285989,
0.0028694796,
0.013445189,
0.023020979,
-0.013523359,
0.025756918,
0.03538482,
-0.012005564,
-0.019307917,
-0.022916751,
-0.028610112,
-0.03272705,
0.020675886,
-0.01237687,
0.007458693,
-0.044296168,
-0.00998618,
0.037391175,
0.027854472,
0.02550938,
-0.004940977,
0.014396254,
-0.035489045,
0.02171815,
0.0044589303,
-0.014292028,
0.0034948373,
-0.022369564,
0.010162062,
-0.010696221,
0.020923425,
0.004302591,
-0.026786152,
0.022291394,
-0.009634417,
0.0068724197,
-0.016611062,
0.00046576117,
0.010787419,
-0.0052210847,
-0.029834772,
-0.017275505,
-0.01753607,
-0.029548148,
-0.025782974,
-0.005006118,
0.01929489,
-0.028427716,
0.022343507,
0.0021871233,
0.0066769957,
0.01866953,
-0.00161795,
0.015777253,
-0.0077257724,
0.03733906,
0.020741029,
0.017731495,
-0.00042382636,
-0.008846205,
-0.013809981,
0.013262793,
0.016454723,
-0.012051163,
-0.010976329,
-0.009816812,
-0.0147089325,
0.014239915,
-0.01882587,
-0.01055291,
0.0060874657,
-0.024180496,
-0.00063635025,
-0.0037716883,
-0.0091002565,
-0.012266129,
-0.01457865,
-0.027646018,
0.011771055,
0.012963143,
-0.0069310474,
-0.009849383,
0.048934236,
0.0056770747,
0.015386404,
-0.0048921206,
0.007790914,
-0.0020535833,
-0.002889022,
-0.02035018,
0.0017783608,
0.011712427,
0.01693677,
-0.0135885,
-0.0036576907,
0.03303973,
0.017444873,
-0.009484591,
0.009849383,
-0.007387037,
0.036713704,
0.009517161,
-0.002910193,
-0.01412266,
-0.0022343507,
0.024610428,
-0.011308551,
-0.016558949,
0.0031495877,
0.0052797124,
0.0014974384,
0.016024789,
0.007927711,
-0.044035602,
0.014161745,
-0.022148084,
0.0055174786,
-0.04450462,
-0.013269307,
0.018708616,
-0.02437592,
0.0071655563,
-0.0043807607,
0.011341121,
0.020688916,
0.008396729,
-0.003856372,
-0.014552593,
0.016975854,
-0.031528447,
0.0382771,
-0.012924058,
0.04275883,
0.0031121315,
0.00808405,
-0.00048041798,
0.009875439,
0.0005598091,
-0.0022278365,
-0.025769945,
-0.015151895,
-0.007504292,
0.019529399,
0.0027994525,
0.007106929,
0.0075954897,
0.0061330646,
0.002447689,
0.005732445,
0.005595648,
0.0028678512,
-0.0111717535,
0.00029395067,
0.026616784,
-0.02005053,
-0.007999366,
-0.01309994,
0.0060320958,
0.0010618052,
0.0026740553,
-0.020936452,
-0.022512875,
0.02535304,
-0.010103434,
0.011790597,
0.012402927,
-0.012637435,
-0.020298067,
0.022799497,
-0.003117017,
0.0057650157,
-0.023112176,
0.018083258,
-0.014487452,
0.023672393,
-0.025470296,
-0.011595173,
-0.01116524,
-0.021079764,
-0.034212273,
-0.002745711,
-0.00073976227,
0.042810943,
0.00069904886,
-0.022682242,
-0.008878776,
0.024897052,
-0.024167467,
-0.020232925,
0.009673501,
0.02543121,
0.0069701322,
0.013484274,
-0.012585322,
0.0026349705,
0.010950273,
-0.0058496995,
-0.006504371,
-0.025652692,
-0.0062372913,
-0.008585639,
0.014539565,
-0.0050647454,
-0.012181446,
-0.01302177,
0.022499846,
-0.015568799,
-0.0017620755,
0.011406262,
-0.016545922,
0.016819514,
-0.017900862,
0.057532903,
0.020767085,
0.008983002,
0.0485955,
-0.03303973,
0.005491422,
0.030694637,
-0.0027636248,
-0.013914208,
-0.0144223105,
0.0047357813,
0.015829366,
0.009569275,
-0.008566096,
-0.020845255,
-0.0035371792,
-0.010624566,
0.012611379,
0.0014046119,
0.00149011,
0.013992378,
0.011347636,
-0.026707983,
-0.030877033,
-0.0037716883,
-0.01708008,
0.0081361635,
0.00029781842,
0.021366386,
-0.015282177,
-0.0033173268,
0.018096287,
-0.02360725,
-0.0020649831,
-0.011477918,
0.0065239132,
-0.007054816,
0.01533429,
-0.021301245,
-0.020558633,
-0.021679064,
0.0036609478,
-0.0060679233,
-0.008513983,
0.0010740191,
-0.011888309,
0.005501193,
0.0012059306,
0.0014086833,
-0.002253893,
-0.037625685,
-0.00695059,
-0.0028841365,
0.0088136345,
0.015829366,
0.18281288,
-0.03066858,
0.00016946948,
0.031762958,
-0.0013923979,
0.012292186,
0.005865985,
-0.020675886,
0.0057650157,
0.008181763,
-0.00031512164,
0.020819198,
-0.031762958,
0.00037232394,
0.02725517,
0.0124941245,
-0.02907913,
-0.0065239132,
-0.0005024032,
-0.0033222125,
0.00087533786,
-0.009022087,
-0.0033042985,
-0.003667462,
0.034837633,
-0.015985705,
0.003397125,
0.003064904,
0.011230381,
0.0015340805,
-0.013809981,
-0.01420083,
-0.009399907,
-0.0020079843,
-0.004178822,
0.005993011,
-0.009627902,
-0.008702894,
0.010403085,
-0.007093901,
0.008963459,
0.00024305892,
-0.021457585,
-0.005022404,
-0.016650148,
0.016115988,
-0.0005862728,
-0.0055174786,
-0.008272961,
-0.013966321,
-0.028062925,
0.00033771756,
0.021288216,
0.029496035,
-0.01898221,
0.008624724,
0.015555771,
0.031137599,
0.026382275,
0.016571978,
-0.034264386,
0.0006615926,
-0.024636485,
0.028870678,
-0.024050213,
0.034759462,
0.0068659056,
-0.006194949,
-0.0026968548,
-0.0005309026,
-0.0010919331,
-0.0076736594,
-0.028115038,
0.0027994525,
-0.000918494,
0.0004820465,
0.008527012,
0.010976329,
-0.004397046,
-0.0003922735,
0.004693439,
-0.009171912,
-0.029105186,
-0.0075303484,
-0.013979349,
-0.03856372,
0.008787578,
-0.0035436933,
-0.011666829,
-0.032205917,
0.0015967791,
0.0063480316,
-0.0000030423716,
-0.0063480316,
0.010533368,
-0.026291078,
0.005416509,
-0.013002228,
-0.01181014,
0.0033775826,
-0.022734355,
0.04927297,
0.025756918,
0.01533429,
0.002773396,
-0.005002861,
-0.026538614,
0.0091002565,
0.0002746118,
0.011738484,
0.017379731,
-0.033769313,
0.0021333816,
-0.02619988,
-0.028036868,
0.002889022,
0.030564355,
-0.00994058,
0.0052080564,
-0.026330162,
-0.014044491,
-0.030434072,
0.045442656,
-0.017939948,
-0.017627269,
0.017835721,
0.0004543614,
0.005087545,
-0.005732445,
-0.03098126,
-0.014005406,
-0.021548782,
-0.0068724197,
-0.0073218956,
0.011477918,
0.01412266,
-0.002205037,
0.003481809,
0.010070864,
0.043618694,
-0.01988116,
-0.0041527655,
0.03189324,
-0.017496986,
0.029469978,
-0.013060855,
0.01511281,
0.002797824,
-0.0023499767,
0.0006107008,
-0.026968548,
-0.012793775,
-0.0038726574,
-0.021001594,
0.012715605,
-0.000629429,
-0.004302591,
-0.04442645,
-0.00065792835,
-0.012292186,
-0.016142044,
0.015594856,
-0.0112434095,
-0.025235787,
0.0037488888,
-0.0035176368,
-0.16280144,
0.017848749,
0.02064983,
-0.0071394998,
0.018044174,
-0.008963459,
-0.009002544,
-0.0055109644,
-0.010507312,
0.017939948,
0.017796636,
-0.0020096127,
-0.019529399,
-0.011295523,
-0.010188119,
-0.01594662,
0.0032554425,
0.04236798,
0.0070678443,
0.0009673501,
0.02824532,
-0.030329846,
0.01503464,
-0.02193963,
-0.0066248826,
0.0047878944,
0.0037977449,
0.0049800617,
0.0056640464,
-0.03720878,
-0.024245637,
-0.00058016577,
-0.0025242302,
0.029131243,
0.0063122036,
-0.017067052,
0.0023678907,
-0.021509698,
-0.009002544,
0.019086435,
0.03577567,
0.013125996,
0.00025649436,
0.0043253903,
-0.0049898326,
0.009445506,
0.013705755,
0.017952975,
0.015073725,
0.003068161,
0.01860439,
-0.009881954,
0.0070678443,
0.020024473,
0.01715825,
0.0028124808,
0.02292978,
0.005543535,
-0.008299017,
-0.010227203,
-0.0029167072,
-0.011047985,
0.014552593,
0.0107613625,
0.014174773,
-0.021613924,
0.010214175,
0.008657295,
-0.0037977449,
-0.009530189,
-0.032544654,
-0.0007018988,
-0.010233717,
-0.0060223243,
0.0023483483,
0.0350982,
0.002226208,
-0.022708299,
-0.0059799827,
0.016350497,
-0.019985387,
0.01275469,
-0.040804587,
-0.021731177,
-0.023776619,
0.022682242,
0.024284722,
-0.007966796,
0.011803625,
-0.012526696,
0.005374167,
-0.028948847,
-0.007204641,
-0.01648078,
0.009745156,
0.012637435,
0.021431528,
-0.008605182,
0.0059897536,
-0.0063480316,
0.026512558,
-0.016754374,
-0.0142789995,
0.0006273933,
0.036765818,
-0.008077536,
-0.03507214,
-0.001648078,
0.04546871,
-0.015295206,
0.00668351,
-0.0031267882,
0.0144223105,
0.020324124,
-0.012526696,
0.016363526,
0.0047488096,
-0.02423261,
0.022786468,
-0.031398166,
0.045208145,
0.005732445,
-0.018382909,
0.017809665,
-0.012415955,
-0.0044361306,
-0.12663493,
-0.058262486,
-0.0015316376,
0.0025730862,
0.0054523367,
-0.0043156194,
0.0015430374,
0.032075636,
-0.0039215134,
0.026225936,
-0.029313639,
0.0016887913,
0.01852622,
-0.0014379969,
0.00816222,
0.014018434,
0.035280593,
0.013979349,
-0.04447856,
0.037417233,
0.0047878944,
-0.026629813,
-0.007810456,
-0.024506202,
-0.0050712596,
0.006885448,
-0.046458863,
0.0048823496,
0.004302591,
0.006833335,
0.017040996,
-0.0066639674,
0.009471563,
-0.0017620755,
0.0009168655,
-0.0031479592,
-0.0011000758,
-0.004283048,
0.0054849074,
-0.005217828,
-0.00033038916,
-0.00045598994,
0.0040322538,
0.00555982,
0.00095595035,
-0.017301561,
-0.0064099156,
-0.014135689,
0.004178822,
-0.025379097,
-0.019399116,
-0.023672393,
-0.012689549,
-0.009934067,
0.012552752,
-0.03455101,
0.039136965,
0.0060874657,
-0.0011049614,
-0.017848749,
0.025756918,
0.015164923,
-0.014292028,
0.016129015,
0.016376553,
-0.017627269,
-0.008820148,
-0.03129394,
-0.0013500559,
-0.03924119,
-0.0049442337,
0.019021295,
0.005002861,
-0.005738959,
-0.020311095,
-0.0015039525,
-0.021574838,
-0.019620595,
0.004071339,
-0.03319607,
-0.024897052,
-0.02231745,
-0.005041946,
0.0025958857,
0.0041592796,
-0.0017197335,
0.012930572,
-0.0010805334,
-0.0034687808,
-0.00062169344,
-0.0015894506,
0.02178329,
0.0265777,
-0.016129015,
-0.022617102,
0.022512875,
-0.016441695,
-0.010194632,
0.031163655,
0.008748493,
0.009517161,
-0.005351368,
-0.03210169,
0.010644108,
0.005869242,
-0.010429141,
0.009184941,
0.0005496307,
0.0075303484,
-0.005865985,
-0.005318797,
0.00024489104,
0.003713061,
0.023190346,
-0.0054393085,
-0.039293304,
-0.021613924,
-0.025014305,
-0.004813951,
0.0054295375,
0.014995555,
0.023880845,
0.011262951,
0.028610112,
0.014213858,
-0.032935504,
-0.0047064675,
0.0032163577,
-0.033222124,
0.024193523,
-0.01085256,
-0.017913891,
-0.003807516,
-0.03720878,
-0.015751196,
0.01936003,
-0.037391175,
-0.00060622237,
0.0053318255,
0.016663175,
0.016428666,
-0.0010927473,
-0.001639121,
-0.029808715,
0.010305373,
-0.0015804938,
-0.009321737,
-0.019255804,
-0.010787419,
-0.0038107731,
0.004595727,
-0.0043905317,
0.0325186,
0.027593905,
0.0111717535,
-0.04033557,
0.00018565304,
0.007380523,
0.00035929566,
-0.0036544336,
-0.02772419,
-0.0024460603,
0.012748176,
0.0037847166,
0.012670007,
0.0036055776,
0.010442169,
-0.012357327,
-0.002906936,
-0.00941945,
0.0064946,
-0.029704489,
-0.0044687013,
0.01336702,
0.032466482,
-0.031684786,
0.03181507,
-0.015321262,
-0.0077843997,
0.015204008,
-0.016050845,
0.024949165,
0.0023076348,
-0.0037977449,
-0.025326984,
0.01769241,
0.048908178,
0.022721328,
-0.028974904,
-0.0008435814,
-0.006608597,
0.028062925,
0.009849383,
0.008872261,
0.0014966242,
0.006045124,
0.004110424,
0.012253101,
-0.004954005,
-0.00035990635,
-0.012487611,
0.03645314,
0.0073609804,
-0.006061409,
0.0025258586,
-0.018851927,
-0.016598035,
0.01921672,
0.007608518,
-0.0072176694,
-0.017523043,
-0.008142678,
0.02491008,
-0.0020812685,
-0.03348269,
0.016663175,
-0.047318727,
0.02058469,
-0.006742137,
-0.004169051,
-0.0061656353,
0.0032017007,
0.012858916,
-0.0072241835,
-0.0008631238,
0.0034036392,
-0.0009722357,
0.015503658,
0.029574204,
-0.02035018,
0.008898318,
-0.00028926862,
0.016076902,
-0.01203162,
-0.028115038,
-0.016207185,
-0.01632444,
-0.008969974,
0.013236737,
0.012344299,
0.010572453,
0.06884146,
0.020819198,
-0.024102326,
-0.010240232,
-0.013119482,
0.013204166,
0.026916435,
0.012976171,
-0.01580331,
-0.0076801735,
0.006230777,
-0.03225803,
0.014865273,
-0.036713704,
-0.025496352,
0.035436932,
0.016467752,
-0.0009828212,
0.005006118,
-0.009888467,
0.013575472,
-0.021275189,
0.027854472,
0.011145697,
-0.05260821,
-0.012389898,
0.034264386,
0.013614557,
-0.009543218,
0.004071339,
0.010728792,
0.0023744048,
-0.03098126,
0.011302036,
0.02239562,
-0.038329214,
-0.020845255,
-0.025118532,
0.01063108,
0.019594539,
0.004618527,
-0.0045110434,
-0.024897052,
-0.003667462,
-0.0066118543,
0.023411827,
-0.02590023,
-0.0056477613,
-0.025066419
] |
Oxygen (O2) deprivation, or hypoxia, has profound effects on cell metabolism and growth. Cells can adapt to low O2 in part through activation of hypoxia-inducible factor (HIF). We report here that hypoxia inhibits mRNA translation by suppressing multiple key regulators, including eIF2alpha, eEF2, and the mammalian target of rapamycin (mTOR) effectors 4EBP1, p70S6K, and rpS6, independent of HIF. Hypoxia results in energy starvation and activation of the AMPK/TSC2/Rheb
|
[
-0.016636964,
-0.047807366,
-0.005577526,
-0.04691496,
-0.017019423,
0.013513548,
-0.02512755,
0.0133733135,
-0.01562982,
-0.016369242,
0.015680816,
0.010868208,
0.009440361,
-0.0034835634,
-0.005475537,
-0.0037257874,
0.032942463,
-0.007464323,
0.005233313,
0.011709617,
-0.023521224,
0.028225468,
-0.012359797,
-0.013360565,
0.0020652781,
0.010154285,
0.01638199,
-0.040948603,
0.011046688,
-0.04683847,
0.014928646,
-0.017707849,
-0.0072029764,
-0.004793485,
-0.021430448,
0.0038532736,
-0.01056224,
-0.02766453,
0.008248364,
-0.0057974397,
0.02858243,
0.017401882,
0.01019253,
0.0055679646,
0.011607628,
-0.0121876905,
0.02812348,
-0.01369203,
0.01871499,
0.03426832,
-0.0028461318,
0.0043568444,
0.005414981,
-0.009032405,
-0.005249249,
0.0015577233,
-0.023304496,
0.028990386,
0.003598301,
0.017261647,
-0.020270323,
-0.017197903,
-0.042503934,
0.00995668,
0.00038664206,
0.016968427,
0.024069415,
0.025255037,
0.0093319975,
0.0038532736,
0.02766453,
0.032534506,
-0.01471192,
0.017835334,
0.002788763,
-0.042605925,
-0.024630355,
0.011926344,
0.009733579,
-0.0018342092,
0.019441662,
-0.011958215,
0.008726438,
0.0428354,
0.008426845,
-0.03044373,
-0.019505406,
0.0083758505,
0.008675443,
0.010893705,
0.03426832,
0.011021191,
0.03697103,
0.023049524,
-0.009153517,
-0.0032238099,
0.0065846676,
0.04411026,
-0.008120878,
-0.019620143,
-0.009861066,
0.0067185285,
-0.017950073,
-0.010485749,
-0.032534506,
0.016114268,
-0.008222867,
0.013386062,
0.00856708,
-0.010033173,
-0.023202509,
0.025624748,
0.00056611886,
-0.040540647,
0.0050452705,
0.0063137594,
0.020091843,
0.037863433,
-0.016917434,
-0.011027565,
0.01591029,
0.026848616,
0.0023059086,
-0.025726737,
0.00935112,
-0.014112734,
0.003575991,
-0.004994276,
-0.009370243,
-0.012672139,
0.01824329,
-0.0019728506,
0.006814143,
-0.016280001,
-0.024681348,
0.025841475,
-0.030418232,
-0.017950073,
0.0039106426,
-0.03454879,
0.004551261,
0.013233079,
-0.013169335,
-0.015693564,
-0.015553329,
-0.005115388,
0.014444198,
0.0012820342,
0.007763916,
-0.0019935672,
0.012429914,
-0.018918969,
0.011142303,
0.001025468,
0.010364637,
0.024464622,
0.0074706976,
0.029219862,
0.003862835,
-0.012104825,
0.016050527,
-0.016687958,
-0.0062978235,
0.015438592,
0.0057273223,
-0.0014995576,
0.015349351,
-0.0038692094,
0.010460251,
0.0033592642,
0.015553329,
0.0153621,
-0.034854755,
0.018396273,
0.0035345578,
0.03240702,
-0.0057974397,
0.030137762,
-0.017236149,
0.0037098515,
-0.005988669,
0.004366406,
0.014788412,
0.00061990216,
-0.009319249,
0.010135162,
0.02447737,
-0.0027250198,
0.029908288,
-0.025866972,
0.0041273693,
0.024235146,
-0.007974269,
0.007451575,
-0.64416283,
-0.029755304,
0.005430917,
-0.005112201,
0.006230893,
0.017108662,
0.00091391744,
0.009682585,
-0.011441896,
0.044186752,
-0.001055746,
0.0075089433,
-0.004388716,
-0.042095978,
-0.0035919268,
-0.035645172,
-0.022259109,
-0.019900613,
0.022399344,
-0.02216987,
-0.00015965667,
-0.00007300583,
-0.009478607,
0.0076109325,
-0.00467556,
0.021570683,
0.03286597,
-0.0047871107,
0.00796152,
0.037455477,
0.0048349183,
0.015502335,
0.005357612,
-0.00012489675,
0.047322918,
-0.0069480035,
0.0023871812,
0.03230503,
0.020040847,
0.011448271,
-0.011875349,
0.0083822245,
0.020372313,
0.0023106893,
0.0043377215,
0.022093376,
0.0028955326,
0.006329695,
0.024171405,
-0.0066229138,
0.002849319,
0.023903683,
-0.024745092,
0.02310052,
0.009784574,
0.021162726,
0.029219862,
-0.00065854646,
0.0022118874,
0.0112315435,
-0.01620351,
0.03240702,
-0.019224934,
0.005134511,
-0.009931183,
0.024592109,
-0.021277465,
0.019938858,
0.0075344406,
0.00032807805,
0.025561005,
0.020142836,
0.0121813165,
0.0066866567,
-0.00016344142,
0.015655318,
0.017299892,
0.02970431,
0.0009856285,
0.02449012,
0.004057252,
0.012958983,
-0.019186689,
-0.0069225063,
0.025752233,
0.011849852,
-0.03977573,
0.02243759,
0.0032540879,
-0.0017752468,
-0.007273094,
-0.008235616,
-0.020219328,
-0.034421302,
-0.02812348,
-0.003499499,
-0.012506407,
0.022743557,
0.030979173,
-0.011722366,
-0.01079809,
0.009555099,
-0.00616715,
0.009969429,
0.027588036,
0.00084937754,
-0.045563605,
-0.03090268,
0.03982672,
-0.018880721,
0.009376618,
-0.004892287,
-0.0028748163,
-0.009727205,
0.00231547,
-0.013092844,
0.031055665,
0.012359797,
-0.0025545068,
-0.043421835,
0.026211185,
0.0058548087,
0.014507942,
-0.010931951,
0.02401842,
0.01545134,
-0.0083758505,
-0.008643571,
-0.017159658,
-0.0030676392,
0.016522225,
0.014278467,
0.024936322,
-0.020270323,
0.02988279,
0.011569383,
0.022475835,
0.0063615665,
0.033375915,
-0.021838404,
-0.026542649,
-0.0065527963,
-0.008917667,
-0.022590574,
-0.012882492,
-0.00621177,
-0.013526297,
0.006833266,
0.019441662,
-0.005357612,
-0.0050038374,
0.004181551,
-0.016624214,
0.029959282,
0.02326625,
-0.02429889,
-0.011473767,
-0.017618608,
-0.03220304,
-0.006756774,
0.0075344406,
0.02010459,
-0.01149289,
0.016318247,
-0.030826189,
-0.016700706,
-0.0020270322,
0.012072953,
-0.008860298,
-0.02038506,
-0.021978639,
-0.02494907,
-0.0028748163,
-0.007923274,
-0.006489053,
0.003000709,
-0.011805232,
0.010747096,
-0.0132458275,
-0.012672139,
0.020652782,
-0.003658857,
-0.037480973,
0.011875349,
0.012340674,
0.027333064,
0.020397808,
0.025968961,
0.005698638,
0.035033237,
-0.024120409,
-0.00051512435,
-0.010288145,
0.02616019,
0.016649712,
-0.031361632,
-0.007094613,
-0.009242757,
-0.0039170166,
0.019301428,
0.03182058,
-0.025382524,
0.0074133286,
-0.012149445,
0.036257107,
0.0121876905,
-0.010007675,
-0.007834033,
-0.020142836,
0.002089182,
0.01014791,
-0.0014668893,
-0.01480116,
0.0020365939,
-0.018740486,
0.0054277293,
-0.0040923106,
0.011843478,
-0.023215257,
-0.024286142,
0.0037130387,
-0.011155052,
0.024936322,
-0.01759311,
0.0065400475,
-0.007897777,
0.014405953,
0.0052906815,
0.010077792,
0.0047010574,
-0.016815444,
-0.018077558,
0.005759194,
0.005316179,
-0.0133733135,
0.0056635793,
0.0045385123,
-0.013679281,
0.042784404,
0.009816445,
0.0056062103,
0.00087567157,
0.0030580778,
-0.018409023,
-0.0011943873,
0.002103524,
0.03528821,
-0.011390901,
-0.028174473,
-0.0130291,
-0.0041082464,
0.0038182149,
-0.0015593169,
0.0038373377,
-0.004704245,
-0.0047871107,
0.0073814574,
0.016917434,
0.026950605,
0.009994927,
0.017529367,
-0.002246946,
0.008235616,
-0.013602789,
-0.004850854,
0.017656853,
0.029296353,
0.006259578,
-0.009191763,
-0.0032668365,
-0.036920033,
0.0023887747,
0.006285075,
-0.026568146,
0.0298063,
0.0072475965,
-0.020512547,
0.003582365,
0.0372515,
0.010045921,
0.0071392334,
-0.008248364,
0.050663058,
0.019505406,
-0.0241969,
-0.011193298,
-0.056144968,
0.0009123239,
-0.01703217,
0.016713455,
-0.0054850983,
-0.0049879015,
-0.0033369542,
-0.0063966257,
-0.013424308,
-0.019390667,
0.010696101,
-0.008822053,
0.03824589,
-0.0019569148,
-0.005399045,
-0.014495193,
-0.017682351,
0.01759311,
0.055635024,
0.0027473299,
0.023992922,
0.000108662156,
0.005255623,
-0.021098984,
-0.0037130387,
0.003920204,
0.0027871693,
-0.016407488,
0.019020958,
0.012672139,
-0.014507942,
-0.0023553094,
0.01369203,
0.0011856226,
-0.0006541641,
-0.008968662,
0.022577824,
-0.011677746,
0.02524229,
0.017516619,
-0.001222275,
0.019212186,
-0.028811906,
0.021736415,
-0.011142303,
-0.025369775,
0.012143071,
-0.018485514,
-0.0043090372,
-0.004085936,
0.013679281,
-0.010689727,
0.0027186454,
0.0061798985,
-0.0010230776,
-0.03212655,
-0.029041382,
0.0057974397,
0.0067057796,
-0.012327926,
0.011397276,
0.037863433,
0.031616606,
0.0059472364,
0.011856226,
0.030775195,
0.0021353955,
0.005593462,
0.0023569032,
0.02177466,
0.0006565545,
0.003658857,
-0.00036492955,
-0.020512547,
0.012200439,
-0.007317714,
0.02651715,
0.021481443,
0.002587972,
0.021353956,
0.0047839237,
-0.0035026863,
0.004210235,
-0.01293986,
-0.011652248,
0.02551001,
0.00011961801,
-0.02354672,
0.01796282,
-0.01815405,
-0.033452407,
-0.0121876905,
-0.008318482,
-0.0034708148,
0.0005051645,
0.014418702,
-0.015566078,
-0.004449272,
-0.021468693,
-0.02661914,
0.017860832,
-0.015056133,
0.0035409322,
0.0032062805,
0.015043384,
-0.003620611,
-0.018498262,
-0.009784574,
0.013500799,
-0.012665764,
-0.0223356,
0.014036242,
0.027486049,
0.034599785,
0.0008422064,
-0.03240702,
0.01610152,
-0.001358526,
-0.036843542,
0.0044110264,
0.0060938452,
-0.04133106,
-0.0014780443,
-0.0152728595,
0.00027529075,
-0.027537042,
0.0055297185,
-0.036818046,
0.016178012,
0.0001500952,
0.00084937754,
-0.008873047,
0.0011107244,
0.011269789,
0.018230543,
0.017746095,
0.003658857,
0.00025477342,
-0.008484214,
-0.02942384,
-0.005523344,
-0.03044373,
-0.0023138765,
-0.0031281952,
-0.0035791781,
0.009070651,
0.0034293816,
-0.005807001,
0.013615537,
0.009376618,
0.019594645,
-0.0023903681,
0.015374849,
0.002675619,
-0.00059002254,
0.02802149,
-0.012225937,
0.013449806,
-0.025395272,
-0.024043918,
0.011269789,
-0.0012684887,
-0.0037767817,
0.0044779563,
-0.013730275,
-0.0218894,
-0.04140755,
0.010453877,
-0.023482978,
0.03982672,
0.0017338138,
-0.019301428,
-0.018128553,
0.008720064,
-0.025828727,
-0.013921505,
-0.024706846,
-0.015438592,
-0.010817213,
-0.0038341507,
0.006106594,
-0.02187665,
0.029092375,
-0.034217324,
-0.026466157,
0.010479375,
0.0053671733,
0.005867557,
-0.0099248085,
0.0025306032,
-0.03926578,
0.0048444797,
-0.008356728,
-0.042401947,
-0.008127252,
-0.0181668,
0.02952583,
0.020869508,
0.0288629,
-0.0029465272,
0.014291215,
0.013360565,
0.013296822,
-0.00398076,
0.015043384,
0.011448271,
-0.020869508,
0.021570683,
0.0008804523,
0.0013633067,
0.021455945,
-0.011531136,
0.012825122,
0.015961286,
-0.021353956,
-0.008885795,
0.0077702906,
0.0028206345,
-0.018205045,
0.0149158975,
-0.03771045,
0.008203744,
-0.015872044,
-0.04105059,
0.030214254,
-0.013284073,
0.02048705,
-0.03192257,
0.002962463,
-0.024643103,
0.0044779563,
-0.0049655917,
-0.003193532,
-0.016178012,
-0.016866438,
0.007406954,
-0.0028015117,
0.015540581,
0.0044365237,
0.006042851,
-0.0051217624,
-0.021634426,
0.011014817,
0.014775663,
-0.0052237515,
-0.00059081934,
-0.0065591703,
-0.025777731,
-0.0029082813,
-0.016471231,
-0.021991387,
-0.035670668,
-0.009886563,
0.02038506,
-0.028505938,
0.023903683,
-0.014163729,
-0.011371778,
0.034319315,
-0.020933252,
0.021047989,
-0.0108745815,
0.028811906,
0.010052295,
-0.0076683015,
-0.020946,
-0.0045448868,
0.0038309635,
0.00065137533,
0.032814976,
-0.011084935,
0.0027043032,
-0.010294519,
-0.0052588102,
0.0058293114,
-0.012793251,
-0.019620143,
0.01778434,
0.005593462,
0.0052046287,
0.00078802474,
-0.02522954,
-0.025459016,
-0.0038437122,
0.005682702,
-0.006042851,
-0.012595647,
-0.012461786,
-0.012627519,
0.025624748,
0.0037512847,
-0.01443145,
0.016624214,
-0.018256038,
-0.00020009374,
-0.02876091,
-0.01750387,
0.007496195,
-0.020996995,
0.028735414,
0.0003157278,
0.023980174,
0.00034281865,
-0.006998998,
0.0077702906,
-0.003438943,
-0.021481443,
0.035237215,
-0.004302663,
-0.013806767,
0.01991336,
0.010600487,
0.0059344876,
-0.005701825,
-0.0076874243,
-0.0005740868,
-0.011977338,
0.012627519,
0.0073113395,
0.02234835,
-0.018230543,
-0.0017465624,
-0.022195365,
-0.0246686,
-0.019186689,
-0.023444733,
0.0218894,
-0.026899612,
-0.00031333743,
-0.00050157896,
0.014762915,
0.010230776,
-0.0056667663,
0.0013075314,
0.0013561356,
0.026874114,
-0.018498262,
0.03182058,
0.020907754,
-0.013437057,
0.0011266603,
0.0045799455,
-0.034523293,
-0.044186752,
0.017554864,
-0.0030931365,
-0.027001599,
-0.017287143,
0.0067950203,
0.0049879015,
0.0084969625,
-0.002659683,
0.02633867,
-0.007897777,
-0.0050165863,
-0.025943464,
-0.002860474,
0.027409555,
-0.040158186,
0.026466157,
0.022539578,
-0.025153048,
-0.00651455,
-0.00077288575,
-0.012882492,
0.0016071242,
-0.010581363,
-0.011907221,
-0.013424308,
0.0042962884,
-0.014622679,
-0.012576524,
0.011365404,
-0.0010501684,
-0.01591029,
0.021455945,
-0.00043903096,
0.025344279,
-0.027486049,
0.002527416,
-0.0014987609,
-0.011856226,
-0.023431983,
0.00703087,
0.0026580894,
-0.006998998,
-0.015374849,
-0.0020413746,
-0.0006876293,
0.025000066,
0.003129789,
-0.022539578,
-0.025777731,
-0.0035026863,
-0.04462021,
-0.0034708148,
0.011308036,
0.016993925,
-0.004627753,
0.011104058,
-0.008025263,
-0.0053002434,
-0.001176858,
0.00094100833,
0.0013967719,
-0.021812906,
-0.0026803997,
0.0023712453,
0.005411794,
-0.016751701,
-0.024158655,
-0.019977104,
0.04433974,
-0.01927593,
-0.010109664,
0.03342691,
-0.0011561414,
0.0069862497,
-0.008904918,
0.004627753,
0.011817981,
0.0042931014,
0.006304198,
-0.02848044,
-0.0016007499,
0.031387128,
0.020423306,
-0.015808303,
0.0032317778,
0.008082632,
0.023113267,
-0.0040381285,
-0.010664229,
-0.0029289979,
0.028276462,
0.0065974165,
0.009064277,
0.036920033,
0.006259578,
-0.0022899727,
0.022539578,
-0.013513548,
-0.019441662,
0.00917264,
0.009019656,
0.0002489967,
0.032381523,
0.017350886,
-0.031616606,
0.0007167121,
-0.0062818876,
-0.031973567,
-0.019722132,
0.00547235,
-0.020984245,
-0.0083822245,
0.0069288807,
-0.011932719,
-0.02942384,
-0.01880423,
0.014048991,
-0.004060439,
-0.006603791,
0.005160008,
-0.01042838,
0.0030405484,
-0.009618842,
-0.0070372443,
0.010931951,
0.0055711516,
-0.017236149,
-0.019135695,
-0.026848616,
0.03176959,
0.1945951,
-0.018689493,
-0.0153621,
0.022883791,
0.0020413746,
-0.0074260775,
0.00015188799,
0.00012489675,
-0.0019776314,
-0.012493658,
0.0020270322,
-0.00926188,
0.0023298122,
-0.0046978705,
0.0023696518,
-0.0020955561,
-0.022705311,
0.019938858,
-0.024910824,
-0.0067376513,
-0.023903683,
0.007336837,
0.005319366,
0.0034070716,
0.03248351,
0.00828661,
-0.03498224,
0.014507942,
0.031897075,
-0.008879421,
-0.015068881,
0.0038692094,
0.0027983245,
-0.0061289044,
0.004245294,
0.012825122,
0.0023855874,
-0.01285062,
-0.0018023377,
-0.0049050357,
0.014176478,
0.0325855,
-0.00020089053,
-0.004312224,
0.005220564,
0.017261647,
-0.025650244,
-0.008898544,
-0.015515083,
0.0009242757,
-0.039648242,
-0.008783806,
0.0074324515,
0.039903212,
0.009580596,
0.002505106,
0.008522459,
0.029092375,
-0.003333767,
-0.0103965085,
-0.012767754,
0.0045034536,
-0.013284073,
-0.0030198318,
-0.032916963,
0.039928712,
-0.0381694,
-0.0046819346,
-0.017822586,
-0.019263182,
-0.00787228,
-0.0017672789,
-0.029015884,
-0.011626751,
-0.011875349,
-0.01010329,
0.01760586,
0.009886563,
0.0020716526,
0.025038311,
0.0022947534,
-0.02551001,
-0.013207582,
0.02262882,
-0.0055424673,
-0.052524358,
0.025076557,
0.018128553,
-0.021302963,
-0.005070768,
0.019301428,
-0.017401882,
-0.011084935,
0.026823118,
0.000108562555,
-0.01880423,
-0.008120878,
0.0014923866,
-0.022616072,
-0.030749697,
-0.024961818,
0.085517816,
-0.008324856,
0.0053607994,
0.0060141664,
-0.0014397985,
-0.0066802823,
0.01936517,
0.0009481794,
0.0025035124,
0.0139597505,
-0.018689493,
0.005395858,
-0.004324973,
-0.013437057,
0.0068205176,
0.010696101,
-0.029959282,
0.028097982,
-0.042809904,
0.0015274453,
-0.0017704661,
0.022565076,
0.014673674,
-0.0068587633,
0.0028126666,
-0.017924575,
-0.003030987,
-0.01378127,
-0.033477902,
0.009676211,
0.0066802823,
0.003738536,
0.009765451,
0.0176951,
0.004528951,
0.019887865,
0.00068324694,
0.01038376,
0.02661914,
-0.0195564,
-0.007196602,
0.009121645,
0.015719062,
0.001869268,
-0.030061271,
0.01601228,
0.000054480475,
0.0011824355,
0.002398336,
-0.009669837,
-0.015617073,
-0.004570384,
-0.0016142954,
0.018409023,
-0.0007912119,
0.0003693119,
-0.03125964,
-0.007859531,
0.009070651,
-0.005038896,
0.011486516,
0.003515435,
-0.034089837,
-0.0013378095,
0.013768521,
-0.15798104,
-0.009861066,
0.013590041,
-0.041586034,
0.050153114,
-0.003160067,
0.012015585,
0.0027839823,
0.00036572633,
0.0030660457,
0.011658623,
0.0021672673,
-0.0095678475,
-0.012232311,
0.002849319,
-0.003881958,
0.009191763,
0.016305499,
0.00025138707,
-0.0012063392,
0.018855225,
-0.010715224,
0.020652782,
-0.0030740136,
0.00034222106,
0.0062818876,
0.0067376513,
0.0021051175,
-0.013475303,
-0.0030150511,
-0.043523826,
0.01564257,
0.0030437356,
-0.012856994,
0.009816445,
0.004764801,
0.007859531,
0.004885913,
-0.008114504,
0.031616606,
0.027639031,
0.0034835634,
-0.012391669,
-0.0008939977,
-0.00893679,
0.014354958,
0.011065812,
0.011607628,
0.020257574,
-0.00037548703,
0.015234614,
-0.009797323,
-0.009134394,
0.012117573,
0.0044715824,
0.0015346165,
0.00707549,
-0.0020190643,
-0.01898271,
-0.0124171665,
-0.014622679,
-0.01881698,
0.022424841,
-0.0061161555,
0.007496195,
-0.018638497,
-0.0018453643,
0.0121813165,
-0.020499798,
0.0018820167,
-0.031055665,
-0.01610152,
0.014813908,
0.008815678,
0.016904684,
0.010855459,
-0.016738951,
0.0061289044,
-0.00094658585,
0.032330528,
-0.00037409263,
-0.00005592466,
-0.029474834,
-0.003582365,
-0.0042739785,
0.0030277998,
0.0008820459,
0.024655852,
-0.020181082,
-0.017860832,
0.027613534,
-0.0067376513,
-0.012837871,
0.0124171665,
0.029500332,
-0.001120286,
0.005357612,
-0.008203744,
0.019479908,
0.006049225,
0.020142836,
-0.009070651,
-0.00584206,
-0.00035636406,
0.03939327,
-0.011996461,
-0.015795553,
0.0072922166,
0.05818475,
-0.011142303,
-0.00889217,
-0.012442663,
0.0011864194,
0.026109196,
-0.0076109325,
0.010001301,
0.008522459,
-0.031208647,
-0.020703776,
0.0041942997,
0.07174929,
0.0122960545,
-0.018613001,
0.021570683,
-0.016649712,
-0.03426832,
-0.13136189,
-0.028352955,
0.021965891,
0.0056062103,
0.004548074,
0.025306031,
0.000050123035,
0.01056224,
-0.0074898205,
0.026670136,
-0.024617605,
-0.00865632,
-0.005861183,
0.016585968,
0.02020658,
-0.025586503,
0.03296796,
-0.010778967,
-0.014954144,
0.037302494,
-0.0041879253,
0.01945441,
-0.012385295,
0.0006545625,
-0.0030596713,
-0.01131441,
-0.022871044,
0.036078624,
0.0044142134,
-0.007253971,
0.007719296,
-0.014584433,
0.022883791,
-0.0041337437,
-0.011664997,
0.0073814574,
0.015221865,
-0.020703776,
0.025943464,
-0.013628286,
0.009937557,
0.03146362,
0.025752233,
-0.003477189,
0.009293752,
-0.012557401,
-0.011805232,
-0.0027632657,
0.006998998,
-0.0040668133,
-0.033452407,
-0.00735596,
-0.03205006,
-0.010026798,
0.012264183,
-0.02552276,
0.0251403,
0.034956746,
-0.017236149,
0.011212421,
0.027690025,
0.0017577175,
0.0040731877,
0.0055424673,
0.0062787007,
-0.03192257,
-0.011161426,
-0.055940993,
0.01601228,
-0.031310637,
-0.0101606585,
0.010785341,
0.011875349,
-0.0003163254,
-0.022233611,
-0.012920737,
-0.027256573,
-0.022654317,
-0.011907221,
-0.0149158975,
-0.023228005,
-0.03146362,
0.013590041,
-0.03844987,
-0.0058548087,
0.009510479,
0.011097683,
-0.010613235,
0.009918435,
-0.007394206,
-0.010785341,
0.034395806,
0.0052651847,
-0.0109893195,
-0.012136697,
0.005217377,
-0.002830196,
0.0008716876,
0.016114268,
-0.009688959,
-0.010485749,
-0.016496727,
-0.04709344,
0.004264417,
0.009899312,
-0.014099985,
0.008433219,
-0.008547957,
-0.0030883558,
0.0036014882,
-0.012372546,
-0.01261477,
-0.025548255,
0.0008422064,
-0.012557401,
-0.018893471,
-0.022501333,
-0.015935788,
0.014571684,
0.0001429241,
0.00040954977,
0.020589039,
-0.013755772,
-0.0059982305,
0.008694566,
0.032993454,
0.00059759204,
-0.026287677,
-0.01140365,
0.011849852,
-0.014507942,
0.0024461434,
0.0130163515,
-0.034956746,
-0.00039500836,
-0.0007035651,
-0.02661914,
-0.015859297,
-0.017911825,
0.009746328,
0.013921505,
0.030188758,
-0.00519188,
-0.022144372,
0.0045448868,
-0.019008208,
0.015132625,
-0.0043154117,
-0.029143369,
0.013067346,
-0.00023764244,
-0.028327458,
0.034395806,
0.023036776,
-0.027639031,
-0.009816445,
-0.013666532,
-0.012315177,
-0.009529602,
-0.010026798,
-0.00865632,
-0.021047989,
0.01155026,
0.0071583563,
0.01369203,
-0.01424022,
0.03939327,
-0.0035473064,
-0.016343744,
-0.007955145,
-0.007661927,
-0.016063275,
-0.039342273,
-0.0041082464,
0.017860832,
-0.0002782787,
0.014520691,
0.014877652,
-0.010485749,
0.028174473,
-0.010007675,
0.015260111,
0.029066877,
-0.009013282,
-0.020474302,
0.018778732,
0.024337135,
-0.009376618,
-0.0032891468,
0.031208647,
0.00028206344,
-0.02048705,
-0.01075347,
0.0030660457,
0.013832265,
0.0075089433,
0.03735349,
0.021825656,
-0.00094419543,
-0.007936022,
-0.0043504704,
0.00638069,
0.01079809,
-0.00781491,
0.0017545302,
-0.013768521,
-0.026568146,
0.012130322,
-0.01963289,
-0.02392918,
-0.01778434,
0.007496195,
-0.020652782,
0.017822586,
-0.0023170635,
0.0051249494,
-0.012021959,
0.008273861,
-0.014291215,
0.0123343,
0.0011346281,
0.020117339,
0.020283071,
0.025255037,
0.010919202,
-0.005504221,
0.013169335,
0.001267692,
0.031667598,
-0.032432515,
0.039214786,
-0.0035186221,
0.029270856,
0.0073049655,
-0.031667598,
-0.01432946,
0.010332765,
-0.0015290389,
0.00497834,
0.010976571,
0.005153634,
0.060785472,
0.011104058,
-0.027919501,
-0.0149158975,
0.00949773,
0.034319315,
0.010938325,
0.008796555,
-0.019811371,
-0.016636964,
0.016713455,
-0.011295287,
0.016802695,
-0.04077012,
-0.016726203,
0.0069862497,
0.00084379996,
0.022641568,
0.01881698,
-0.00016891936,
0.015604324,
-0.004462021,
0.007483446,
0.009274629,
-0.04255493,
0.0011808419,
0.052575354,
-0.012958983,
-0.0006155198,
-0.04648151,
0.008292984,
-0.0054532266,
-0.017006673,
0.005440478,
0.03332492,
-0.011575757,
0.0004661218,
-0.0058165626,
0.03128514,
0.012882492,
-0.006667534,
-0.000020504878,
-0.028633425,
-0.039928712,
-0.0037130387,
-0.008975036,
0.018485514,
-0.0012493659,
-0.006367941
] |
The loss of a glutamic acid residue in the AAA-ATPase (ATPases associated with diverse cellular activities) torsinA is responsible for most cases of early onset autosomal dominant primary dystonia. In this study, we found that snapin, which binds SNAP-25 (synaptosome-associated protein of 25,000 Da) and enhances the association of the SNARE complex with synaptotagmin, is an interacting partner for both wild type and mutant torsinA. Snapin co-localized with endogenous torsinA on dense core granules in PC12 cells and was recruited to perinuclear
|
[
-0.028658742,
-0.0096312165,
0.019055162,
-0.020989696,
-0.025839848,
0.024430403,
-0.022247143,
0.027249295,
-0.0007910863,
-0.0075930464,
0.019096617,
0.026116211,
0.00916831,
0.014965003,
0.0057379664,
0.0022264416,
0.026240574,
-0.007116322,
0.0173279,
-0.004242157,
0.001239311,
0.0150617305,
-0.008691586,
-0.025549669,
0.0184748,
0.013755919,
-0.010156305,
-0.029294373,
-0.02103115,
-0.0324449,
-0.000025827974,
-0.0039174315,
-0.00887813,
-0.013147923,
0.008055953,
-0.00079238176,
0.0034165254,
-0.025964212,
0.001808444,
-0.030786728,
0.0078970445,
0.015117003,
-0.015918452,
0.008919585,
-0.017783897,
0.0034407072,
-0.02065806,
0.012857744,
0.009002493,
0.0017436716,
-0.008028316,
0.02408495,
-0.03457289,
-0.00052206515,
0.011282479,
-0.013472648,
0.008885039,
0.0133275585,
0.00087572215,
-0.01113739,
-0.0010639938,
0.0019328069,
-0.021114059,
0.01535191,
-0.004017613,
0.024706764,
-0.007959226,
0.00007470411,
-0.0024492585,
-0.013527921,
0.056433126,
0.020423153,
0.0012151293,
-0.017770078,
0.031919815,
-0.01302356,
-0.011600296,
-0.0037861597,
-0.00858104,
0.023242045,
0.012201384,
-0.014149736,
-0.00066845067,
0.009548308,
0.022689322,
-0.010702119,
-0.010522484,
0.011655568,
-0.01913807,
-0.0015830362,
0.011551932,
0.03341217,
0.008277043,
0.0050366977,
-0.010791937,
0.0022212598,
-0.0065739616,
0.008691586,
-0.04330593,
-0.019234797,
-0.003958886,
0.009541399,
-0.0004359179,
-0.01797735,
0.009665762,
-0.0016944447,
-0.013472648,
-0.012609017,
-0.0018533528,
-0.020215882,
-0.023684226,
0.023117684,
-0.009216674,
-0.03371617,
0.011434479,
0.011669386,
0.041122667,
-0.010273758,
-0.010418848,
-0.017479898,
0.015545364,
0.01680281,
0.022938048,
-0.007966136,
0.035816517,
0.011980293,
-0.009693398,
0.013645375,
-0.00080663164,
-0.016484994,
0.005793239,
0.04032122,
0.011082117,
0.011600296,
-0.0041557937,
0.006097237,
-0.02329732,
-0.0155315455,
-0.02110024,
-0.022896593,
0.006055783,
0.039796133,
-0.048805535,
-0.011358479,
0.015255184,
0.037281238,
0.014978821,
0.0071992306,
0.00800068,
0.022426778,
0.020685697,
0.00052206515,
-0.012913016,
-0.0061732368,
0.02357368,
0.020354062,
-0.00029644146,
-0.0027411657,
-0.03927104,
-0.02226096,
-0.024941672,
-0.001621036,
-0.0053614234,
-0.017880622,
0.029736554,
0.019828975,
0.002321441,
-0.01156575,
0.006339054,
-0.019400613,
-0.0048639714,
0.016277723,
-0.035844155,
0.029349647,
0.005793239,
0.0047188816,
0.010715937,
0.010107941,
-0.014564279,
-0.005499604,
-0.020533698,
0.024610039,
0.020713333,
0.039713223,
-0.012533017,
0.0038794319,
0.03993431,
0.022827502,
0.011462115,
-0.025549669,
-0.009914488,
0.005558331,
0.009693398,
-0.011524296,
-0.6367381,
-0.015324274,
0.018916981,
-0.026461663,
-0.0017022174,
0.04648409,
-0.0062630544,
0.0150202755,
-0.01601518,
0.03133945,
-0.022799866,
0.0103428485,
-0.013085742,
-0.029487828,
-0.035816517,
-0.02074097,
0.015324274,
0.0027653475,
0.044936463,
0.010743573,
-0.019704612,
0.0137835555,
-0.011855931,
0.002143533,
0.049137168,
0.003532252,
0.011185753,
-0.021155512,
-0.009776306,
0.00866395,
-0.022758413,
0.01980134,
-0.0086501315,
0.0232835,
0.042117573,
0.0023318045,
-0.0027532566,
0.016858084,
0.012284292,
0.025950395,
-0.029515464,
0.01390101,
0.004090158,
0.00975558,
-0.009182128,
-0.002190169,
-0.0012695381,
-0.0019673521,
0.00032645263,
-0.03288708,
0.03636924,
-0.0004188612,
-0.029874735,
-0.00062570086,
0.013410467,
-0.000111732305,
0.019704612,
-0.00807668,
0.035097975,
0.010294485,
-0.011558842,
0.0340478,
0.012913016,
-0.0010760847,
-0.001993261,
-0.019386796,
-0.013576284,
0.030012915,
0.009030129,
0.0068986868,
0.022730777,
0.003202345,
-0.008753767,
0.01782535,
0.01652645,
0.038110323,
-0.022357687,
0.010142487,
-0.0051334244,
0.021915508,
-0.0050608795,
0.011731568,
-0.0128024705,
0.00389325,
0.028133653,
0.019925702,
-0.03507034,
0.020354062,
-0.004255975,
-0.007924681,
0.01345883,
-0.008567222,
-0.0018792618,
-0.035567794,
-0.020975877,
0.020050066,
-0.0231315,
0.0028517107,
0.008049044,
-0.006418508,
-0.018861707,
0.017383171,
-0.0083944965,
-0.01367992,
0.035761245,
0.018668255,
-0.044439014,
0.015365728,
0.043996833,
-0.008898857,
-0.012049384,
-0.0066085067,
-0.0059866924,
-0.01767335,
0.0060592373,
-0.025508214,
0.014619551,
-0.012698835,
0.014274098,
-0.028465288,
-0.006477235,
0.010529393,
0.0013109923,
0.0017946259,
-0.011310115,
0.016332995,
0.025729304,
-0.0042007025,
-0.017286444,
-0.012933742,
0.012491563,
-0.015310456,
0.026530754,
-0.02082388,
0.027332203,
0.016913356,
0.006017783,
0.0057034213,
0.005872693,
-0.014329371,
-0.03661797,
-0.018612983,
-0.011510478,
0.001808444,
-0.0035857973,
-0.021818781,
-0.011931931,
-0.017479898,
0.02372568,
-0.019856611,
0.010052669,
0.012622835,
-0.013479558,
0.020506062,
0.001913807,
-0.009458491,
-0.02065806,
-0.020906787,
0.012837016,
-0.017341716,
0.014177372,
0.006432326,
-0.031588178,
0.01695481,
-0.03587179,
-0.035761245,
0.018944617,
0.0041419757,
-0.0059694196,
-0.026516937,
-0.011897385,
-0.026212938,
-0.015573,
0.013210105,
0.0018671709,
0.04131612,
0.0038379775,
0.028769286,
0.022399142,
-0.0050574252,
-0.012394837,
-0.019193342,
-0.02278605,
-0.008871221,
0.029930007,
0.01622245,
0.010563938,
-0.0340478,
0.0020347154,
0.014813004,
-0.024071133,
0.0135555575,
0.0017022174,
0.011075208,
-0.012484655,
-0.014757732,
0.018308984,
0.017258808,
-0.025093671,
0.018585347,
0.019165706,
-0.011800658,
0.018143166,
-0.016070452,
0.02210896,
-0.02263405,
0.004860517,
-0.012995924,
0.0011140844,
-0.0008437678,
0.001525173,
-0.011040662,
-0.0074341386,
-0.0054097865,
-0.0020640788,
0.044107378,
0.0028966195,
0.010439576,
-0.004663609,
-0.01884789,
0.0025511668,
0.009866124,
0.024167858,
-0.0008726994,
-0.022537323,
0.012180656,
0.01615336,
0.022537323,
-0.0021918963,
-0.00887813,
0.0040279767,
0.014522824,
0.008560314,
0.0051714242,
0.000644269,
-0.006169782,
-0.002912165,
0.011814476,
0.03368853,
0.0038656138,
0.004577246,
-0.009928306,
-0.0023888042,
0.003976159,
0.0020347154,
-0.009983578,
0.021680601,
0.014674824,
-0.010964663,
0.024582403,
-0.007903954,
0.010584665,
-0.023020957,
-0.003972704,
-0.019234797,
-0.0130719235,
0.011116662,
0.012249746,
0.05079534,
0.030814365,
-0.0044287015,
-0.0027118023,
0.0062975995,
0.0030330732,
0.004176521,
-0.0093894,
0.019082798,
0.012256656,
0.0029346193,
-0.0187788,
-0.026599845,
-0.0019898065,
0.0055479677,
-0.036258698,
0.020395517,
0.008353042,
-0.015255184,
0.018530075,
0.015158457,
0.0037757962,
-0.017908258,
-0.058312386,
0.01987043,
-0.0008999038,
-0.013548648,
-0.01818462,
-0.0022108962,
0.012242838,
0.0015554,
0.022385323,
0.0034113438,
-0.001440537,
0.0070265043,
0.0145504605,
0.0040348857,
-0.020395517,
0.013286104,
-0.02976419,
0.014059918,
-0.015503909,
0.005755239,
0.0014992639,
-0.027000569,
0.01680281,
0.030151097,
0.009575944,
-0.028852195,
0.0016737175,
-0.010225395,
-0.025452942,
0.012823198,
-0.0012773108,
-0.0021331694,
-0.0016823538,
-0.0027100751,
0.0015139458,
-0.009610489,
-0.00487779,
0.033937257,
0.009016311,
-0.018032622,
-0.016788993,
0.0021849873,
-0.014868277,
0.01987043,
0.045876097,
-0.019193342,
0.0004991789,
0.0065705073,
0.012719562,
0.010349758,
-0.027387476,
0.011075208,
0.0037343418,
-0.014978821,
0.0088919485,
-0.00035732746,
0.00887813,
0.013251559,
0.022426778,
0.006674143,
-0.018944617,
0.005845057,
-0.0083944965,
0.017258808,
-0.0062561454,
0.013037378,
0.025591124,
0.01673372,
-0.033356898,
0.007793409,
0.030897275,
0.018654436,
-0.016719902,
-0.007385775,
-0.003190254,
-0.0012237655,
0.0037239783,
-0.0066845063,
-0.03390962,
0.015476273,
0.027083479,
0.0029639828,
0.01767335,
0.010861027,
0.0042248843,
0.023919133,
0.008684676,
0.0037170693,
-0.017010082,
0.017700987,
-0.0017402171,
-0.011275571,
-0.0044010654,
0.029847099,
-0.006149055,
0.0060661463,
-0.009797034,
-0.0010294486,
-0.010418848,
0.0012125383,
0.008325406,
-0.0012021748,
-0.02860347,
-0.008684676,
-0.013279195,
-0.019345341,
-0.0074341386,
0.010826482,
-0.009161401,
-0.017383171,
-0.010446484,
-0.013237741,
-0.00065160985,
0.004950335,
-0.0420623,
-0.048280444,
0.007247594,
0.024402767,
0.008290861,
0.0030071642,
0.00017024332,
0.026848571,
0.045461554,
-0.010370485,
-0.009382491,
-0.009299582,
-0.026295846,
0.0074686836,
0.008270133,
0.0035339794,
-0.0033007988,
-0.018322801,
0.003827614,
0.021500966,
-0.022730777,
0.028354743,
-0.0041488847,
0.007696682,
0.010398121,
0.03659033,
0.022454415,
-0.0025615306,
0.0043630656,
0.0037585236,
-0.03899468,
-0.020685697,
-0.033439804,
-0.007385775,
-0.017963532,
0.0066050524,
0.010729755,
0.017479898,
-0.020989696,
-0.010826482,
0.0025114398,
-0.02423695,
-0.008622495,
0.010591575,
0.019663159,
-0.0010035395,
0.0137835555,
-0.031311817,
0.010591575,
-0.02262023,
-0.017645715,
0.026323482,
0.00083383603,
-0.014647187,
0.010004305,
0.020879151,
-0.029239101,
-0.013963191,
0.0042110663,
-0.01361083,
0.030040551,
0.004439065,
-0.017618079,
-0.008242497,
0.00967958,
-0.026392573,
0.0038517956,
0.001834353,
-0.003216163,
-0.011627932,
0.02278605,
-0.015241366,
-0.012215202,
0.007613774,
-0.03167109,
-0.012111566,
0.009030129,
-0.008843585,
0.006187055,
-0.010467212,
-0.0059279655,
-0.02780202,
-0.014647187,
0.0007241549,
-0.024720583,
0.0056516035,
-0.0018447165,
0.0089057665,
0.009113038,
0.042753205,
0.022440596,
-0.00578633,
0.026185302,
0.0063079633,
0.016636994,
-0.011171935,
0.016125724,
-0.009126856,
0.03092491,
0.025328578,
0.012940652,
0.032500174,
-0.010121759,
0.0059659653,
0.019552613,
-0.0019120798,
-0.026157666,
0.031201273,
-0.052729875,
-0.0118352035,
0.004584155,
-0.017604262,
-0.021735873,
-0.033495076,
0.0064081443,
0.012615927,
0.011938839,
-0.0054823314,
-0.02510749,
0.032472536,
0.004169612,
0.043692835,
0.0059176018,
0.0024078041,
0.006760506,
-0.035097975,
0.012242838,
0.0046947,
0.014025372,
-0.026005667,
0.017493716,
0.011420661,
-0.009133765,
-0.004611791,
0.0063425084,
-0.01411519,
0.00735123,
-0.016636994,
-0.0007634501,
-0.016042816,
-0.025190398,
-0.032859445,
-0.041675393,
0.020063883,
0.00038992954,
-0.016402086,
0.024181677,
-0.00822177,
-0.0140461,
0.0059936014,
-0.004017613,
0.03056564,
0.016360631,
0.01367992,
0.0036721604,
-0.01608427,
-0.009506853,
-0.017590443,
0.0063494174,
-0.010888664,
0.03230672,
0.011158117,
-0.024485676,
-0.021335147,
-0.014163554,
-0.0030175277,
-0.04286375,
-0.048860807,
0.01987043,
-0.005886511,
0.012685017,
-0.014647187,
0.0034096164,
0.015904635,
0.0021348966,
-0.023311136,
0.012629745,
-0.009928306,
-0.017383171,
-0.03203036,
0.0028586197,
0.003827614,
0.021956963,
-0.0018308983,
-0.0026271665,
0.024900218,
-0.013894101,
0.01222902,
0.0059936014,
-0.0137973735,
0.032638356,
-0.0027446204,
0.02823038,
-0.012049384,
0.027691474,
0.003668706,
-0.026088575,
-0.008967947,
0.047782995,
-0.0128024705,
-0.012961379,
0.013548648,
0.0056654215,
-0.005174879,
-0.01767335,
-0.006504871,
-0.017548988,
-0.03600997,
-0.013776647,
0.024983127,
-0.005727603,
-0.008449769,
-0.0027739839,
-0.007959226,
-0.010177031,
-0.00080879073,
-0.022178052,
0.014439915,
-0.048418626,
-0.016927173,
-0.010757391,
0.014854459,
0.01309956,
0.017852986,
0.012615927,
-0.016291542,
0.026765661,
-0.010791937,
0.012457018,
-0.006556689,
-0.007057595,
-0.022730777,
0.015172275,
-0.016360631,
-0.011759204,
0.0056205126,
0.005558331,
0.0007513593,
0.010619211,
0.009216674,
0.011994111,
0.014799186,
-0.0008342679,
0.022233324,
-0.024665311,
0.009037038,
0.0110959355,
-0.019676976,
-0.00043505427,
-0.006978141,
-0.0019500796,
0.0022523506,
0.012415564,
-0.0330529,
0.003986522,
-0.022302415,
-0.0123672,
-0.015075549,
-0.0024319857,
-0.03133945,
-0.010570847,
0.015255184,
-0.00981776,
0.009043947,
-0.0071646855,
-0.0044148834,
0.009299582,
0.017106809,
-0.017217355,
-0.029460192,
-0.0025632577,
0.016913356,
0.005195606,
-0.009762488,
-0.0025373488,
0.007986862,
-0.015669726,
-0.036921967,
-0.0012738561,
-0.014799186,
0.030040551,
0.006394326,
-0.021570057,
0.006449599,
0.008491223,
-0.04745136,
-0.011393025,
-0.028216563,
-0.00296571,
0.0071508675,
0.026116211,
-0.013949373,
-0.0018913526,
0.004608337,
0.008885039,
-0.004207612,
0.0031591633,
0.022233324,
-0.013838829,
0.04032122,
0.0060074194,
-0.026586026,
-0.014578097,
0.013030469,
0.017811533,
0.0026928023,
0.0028102563,
-0.0021590784,
0.010308304,
-0.008283951,
0.011310115,
0.0063701444,
0.011123572,
0.021058787,
-0.014591915,
-0.011178844,
-0.005775966,
0.017341716,
-0.014343189,
-0.00170999,
0.0069539594,
0.0123672,
0.0050816066,
-0.023698043,
-0.022564959,
0.014868277,
-0.006142146,
0.016250087,
0.0150479125,
0.011489751,
0.002749802,
0.024900218,
-0.010764301,
-0.0071577765,
-0.008435951,
-0.035236157,
-0.0065877796,
-0.006774324,
-0.0075585013,
0.001384401,
-0.012470836,
0.000545815,
-0.0346558,
-0.005254333,
-0.0012004476,
-0.0059348745,
-0.04103976,
0.009665762,
-0.0026858933,
0.013666102,
0.0030434367,
0.0020295335,
-0.02161151,
0.009845397,
0.009914488,
0.004926153,
-0.03645215,
-0.01571118,
0.011234116,
-0.029570736,
-0.0015752636,
-0.038469594,
-0.011807567,
-0.019483523,
0.02082388,
0.17178664,
-0.0018533528,
-0.0062906905,
0.019248614,
-0.00706105,
0.0048190625,
0.009589762,
-0.021224603,
-0.016609358,
-0.004338884,
0.015462455,
0.013852647,
-0.0045219734,
0.00021558396,
0.020132974,
-0.0033301623,
-0.024540948,
-0.0038621593,
-0.019538796,
-0.004542701,
0.016056633,
-0.025135126,
0.01716208,
-0.0019345342,
0.045655005,
0.0027238932,
-0.017590443,
-0.02590894,
0.004960698,
0.015379546,
-0.022703141,
0.012339564,
0.017590443,
0.013237741,
0.015766453,
-0.0088919485,
-0.009154492,
0.010031941,
0.015393364,
0.025452942,
-0.015794089,
0.0028240744,
-0.009209764,
-0.021874053,
-0.02940492,
-0.011123572,
0.006345963,
-0.03269363,
-0.014177372,
0.021238422,
-0.05654367,
0.008622495,
0.009334127,
0.0150479125,
-0.0033025262,
-0.013341377,
0.00031069136,
0.033743802,
-0.010785028,
0.03951977,
-0.0056343307,
0.012498473,
-0.035899427,
0.02096206,
-0.0096312165,
0.01818462,
0.0005078152,
0.014315553,
0.025646396,
-0.027318386,
0.007109413,
-0.033356898,
-0.010653756,
0.007261412,
-0.01273338,
-0.012919924,
0.022233324,
0.016871901,
0.028548196,
0.020284973,
0.013749011,
0.014882095,
-0.00887813,
0.00072890485,
-0.0145366425,
-0.03122891,
0.012049384,
-0.002452713,
-0.002932892,
-0.025204217,
0.0027256205,
-0.025356216,
0.01113048,
-0.023988223,
-0.00055272406,
-0.0130719235,
0.00093013095,
-0.0130719235,
-0.003248981,
-0.025729304,
-0.018239893,
0.058478203,
0.011959567,
0.014274098,
-0.025729304,
-0.010957754,
-0.0022333506,
-0.0024216222,
0.019911883,
-0.0125468355,
0.002748075,
-0.0093755815,
0.0027273477,
-0.01032903,
-0.0044217925,
0.013624648,
-0.00048622442,
-0.012581381,
0.021998417,
0.0005674058,
0.012926834,
-0.030593276,
0.0026979842,
0.00735123,
-0.0072130486,
0.009914488,
-0.0173279,
-0.006477235,
-0.010453394,
-0.040735763,
0.0004689518,
0.008726131,
0.0016642176,
-0.0036065243,
-0.0074617746,
-0.013279195,
0.022426778,
-0.022661686,
0.00836686,
0.017010082,
-0.004642882,
-0.0015813089,
0.021196967,
0.008885039,
-0.0039036137,
-0.006017783,
0.015973724,
-0.005444332,
-0.014218826,
-0.005858875,
-0.019676976,
-0.0021262602,
0.0005091107,
0.003986522,
-0.0013481285,
-0.015006457,
-0.025784576,
-0.03623106,
-0.019220978,
0.01819844,
-0.034738705,
0.0247344,
0.007344321,
0.0098868515,
-0.009658853,
-0.004052158,
-0.17642951,
0.020920604,
-0.005219788,
-0.019884247,
0.026309665,
0.012159929,
0.015738817,
0.0092374,
0.018156985,
-0.0016305359,
0.013859555,
-0.005851966,
-0.024499493,
-0.02014679,
0.0026979842,
-0.011116662,
-0.018129349,
0.011185753,
0.02589512,
-0.0001283572,
0.019704612,
-0.040155403,
0.020892968,
-0.010025033,
-0.009921396,
0.036783785,
0.010812664,
-0.0109163,
-0.0015174003,
-0.007834863,
0.004629064,
-0.0053890594,
0.036479786,
-0.00800068,
0.03462816,
-0.011241025,
-0.017010082,
-0.016871901,
-0.0013040833,
0.026157666,
0.014274098,
0.02896274,
0.007102504,
-0.016636994,
-0.0056343307,
0.024651492,
0.016388267,
-0.009769398,
0.0034389799,
-0.0060005104,
0.032914717,
-0.010052669,
0.0282442,
0.03960268,
0.013997736,
0.014357007,
-0.0035892518,
0.034158345,
-0.0062250546,
-0.0110959355,
-0.003834523,
0.009410127,
0.061076008,
0.013673011,
0.013030469,
-0.033301625,
-0.014674824,
-0.022357687,
-0.02968128,
0.030620912,
-0.008173407,
0.0052646967,
0.0075308653,
-0.0055997856,
0.013472648,
0.02495549,
0.004249066,
0.025204217,
0.007043777,
-0.0071439585,
-0.033799075,
0.0056481487,
-0.028714014,
-0.052729875,
-0.0019086252,
-0.009949033,
0.014205008,
-0.0031159818,
0.016332995,
0.00974867,
-0.007358139,
-0.012871562,
0.008207952,
-0.012899198,
0.011268661,
0.017134445,
0.0077657728,
0.023007138,
0.005319969,
-0.01477155,
0.0026893478,
-0.018004986,
0.013928646,
0.014633369,
0.021266058,
0.016360631,
-0.009762488,
0.0041350666,
-0.00549615,
-0.024540948,
0.017949713,
-0.013762829,
0.006345963,
0.012014839,
-0.014495188,
0.0066568702,
0.0022644412,
-0.00851886,
-0.0030019826,
0.004870881,
0.054830227,
0.0072130486,
0.00033033898,
0.0030365277,
0.013210105,
-0.023808587,
-0.123478554,
-0.037447054,
0.0074686836,
0.0155177275,
-0.016788993,
-0.0031125273,
0.008926493,
0.03706015,
-0.00043267928,
0.04402447,
-0.022136599,
-0.0025563487,
0.0041488847,
-0.00490888,
0.0007673364,
-0.0083944965,
0.023269683,
-0.022426778,
-0.023518408,
0.02495549,
-0.015213729,
0.00048967893,
0.022689322,
0.0031626178,
-0.011469024,
-0.018170804,
-0.020685697,
0.033743802,
-0.004953789,
0.01098539,
0.01041194,
-0.00785559,
0.018682072,
0.0066015976,
-0.02640639,
-0.0022126234,
-0.008401405,
-0.018433347,
0.034545254,
-0.0012168565,
-0.012387928,
0.0047983355,
0.021777328,
0.024872582,
-0.0046877908,
-0.015987543,
-0.0026150756,
0.008131953,
0.015130821,
-0.014619551,
-0.011165026,
0.008069771,
-0.02116933,
-0.02816129,
0.009810852,
-0.022205688,
0.010923209,
0.025328578,
-0.004642882,
0.002255805,
0.019524977,
-0.011019936,
0.011607205,
-0.00073581387,
0.02655839,
-0.013728283,
-0.021017332,
-0.04910953,
0.011683204,
-0.026309665,
-0.009382491,
0.013928646,
-0.0022264416,
-0.01783917,
-0.04891608,
0.0140461,
-0.008912675,
0.0006969505,
0.01666463,
-0.010522484,
-0.022150416,
-0.015683545,
0.017507534,
-0.015904635,
-0.001670263,
-0.021708237,
0.019566432,
0.005865784,
0.0006282918,
-0.03609288,
-0.004176521,
0.0044563375,
-0.00706105,
0.00989376,
-0.01949734,
0.026641298,
-0.007054141,
0.003340526,
0.009465399,
0.008574132,
-0.03987904,
-0.0043043387,
-0.059030928,
0.024361312,
0.018751163,
-0.0077865,
-0.0015243093,
-0.0017514443,
0.0025494397,
0.0012989015,
-0.013541739,
0.004584155,
-0.026682753,
-0.0037585236,
0.021998417,
-0.025010763,
-0.015807908,
-0.015904635,
0.04524046,
-0.014951185,
0.03407544,
0.025218034,
-0.008297769,
0.0066465065,
-0.0055859676,
0.03791687,
0.005851966,
-0.013790465,
-0.00036164562,
0.005924511,
0.008774494,
-0.0069608684,
0.014785368,
-0.04200703,
0.004539246,
0.0068226876,
-0.02132133,
-0.012857744,
0.0031401634,
0.0047292453,
0.0062630544,
0.03056564,
-0.0279402,
-0.035623066,
0.006746688,
-0.020630425,
-0.010563938,
-0.021307511,
-0.04153721,
0.0066845063,
0.0006010874,
-0.010467212,
0.025148945,
0.009320309,
-0.0083944965,
-0.0005298378,
-0.026599845,
-0.016208632,
0.01411519,
-0.0062906905,
-0.0034476162,
-0.002248896,
0.011330843,
0.011614114,
0.023711862,
-0.0020571698,
-0.0065981434,
0.0170239,
-0.051182248,
0.0055479677,
0.0011296298,
-0.033273987,
-0.017963532,
0.01767335,
0.02613003,
0.03150527,
0.0054754224,
0.006411599,
-0.023490772,
-0.009258128,
-0.010923209,
0.009727943,
-0.008111225,
0.0030918,
-0.034876887,
0.022371506,
0.021293694,
-0.013790465,
0.0028344379,
0.014951185,
-0.0027895293,
0.004601428,
-0.009043947,
0.016346814,
-0.01652645,
0.022675503,
0.0063425084,
0.01978752,
-0.017742442,
-0.015476273,
0.01927625,
0.0044943374,
-0.015255184,
0.012194474,
-0.018295165,
-0.01899989,
0.015959907,
0.040459402,
-0.038828865,
-0.0439692,
0.001848171,
-0.023518408,
0.019041343,
0.009251218,
-0.0066914153,
0.004003795,
-0.021874053,
0.006701779,
0.004342338,
-0.006636143,
0.011220298,
0.009347945,
0.023767134,
0.005907238,
0.024430403,
0.0098868515,
0.0093755815,
0.0012591744,
-0.0008027453,
-0.02823038,
0.01811553,
-0.03833141,
0.02787111,
-0.0063425084,
-0.045323372,
-0.003506343,
0.002129715,
-0.00866395,
-0.014826822,
0.033577986,
-0.03363326,
0.09412891,
0.004891608,
0.0029553464,
-0.011026844,
-0.011254843,
0.0017065355,
-0.012291201,
0.011116662,
-0.007116322,
-0.012747198,
0.015904635,
-0.01178684,
0.030538004,
-0.014287917,
-0.007979954,
0.008083589,
0.0008204497,
0.002288623,
-0.011607205,
-0.009686489,
0.02029879,
-0.0023628953,
-0.0063355993,
0.0058830567,
-0.00982467,
-0.0008299497,
0.043720473,
0.019442068,
-0.0037930687,
-0.02887983,
-0.015296638,
-0.019732248,
-0.044079743,
-0.01753517,
0.017134445,
-0.00967958,
-0.017908258,
-0.0034268892,
0.017618079,
-0.009879942,
-0.01600136,
0.012498473,
0.0036479787,
0.00023425999,
0.011503569,
-0.0021089877,
0.010446484,
-0.012595199,
-0.040791035
] |
This protocol describes a basic method for in vivo electroporation in the nervous system of embryonic mice. Delivery of electric pulses following microinjection of DNA into the brain ventricle or the spinal cord central canal enables efficient transfection of genes into the nervous system. Transfection is facilitated by forceps-type electrodes, which hold the uterus and/or the yolk sac containing the embryo. More than ten embryos in a single pregnant mouse can be operated on within 30 min. More than 90% of operated embryos survive and more than 90% of these survivors express the transfected genes appropriately. Gene expression in neurons persists for a
|
[
-0.05280909,
-0.0047737975,
-0.0049374895,
-0.010810363,
-0.014698886,
-0.010556472,
-0.0042292704,
-0.015620908,
-0.040622376,
-0.009173442,
-0.0030867662,
0.025282085,
-0.007262586,
0.002159734,
0.0041023255,
0.011812559,
0.0201642,
0.012841482,
-0.013977305,
0.006257049,
-0.011625483,
0.00860553,
-0.0040856223,
0.0013070316,
-0.019322354,
0.0023518219,
0.008999728,
-0.0119461855,
-0.011044209,
-0.023905734,
0.004463116,
0.008304871,
-0.0057325657,
-0.01594161,
-0.025095008,
-0.010042012,
0.011665571,
-0.016596379,
0.027273115,
0.007984168,
0.03468937,
0.0070354217,
-0.0070487843,
0.010943989,
-0.01155867,
-0.007369487,
-0.0322841,
-0.03030643,
0.006574411,
0.006019862,
0.02235567,
0.0038183697,
-0.006186895,
-0.0025021513,
-0.022342307,
-0.012600955,
-0.0009671199,
0.01670328,
0.007349443,
-0.02052499,
-0.014845875,
-0.0011090977,
-0.034368668,
0.024774306,
-0.016369214,
0.025776502,
0.007903992,
0.0077970913,
0.0025355578,
0.004757094,
0.019736595,
0.0031903265,
-0.003905227,
0.005969752,
0.026805423,
0.0039686994,
-0.017451586,
0.018948201,
-0.004386281,
0.012093174,
0.0020795583,
-0.020351276,
-0.0004818896,
0.029558124,
0.005097841,
0.019362442,
-0.0065309824,
0.023344504,
0.000059975213,
-0.0018891409,
0.007950761,
0.035838556,
-0.0038617982,
0.034662645,
-0.0016310753,
0.030413331,
0.0114049995,
0.038537808,
0.019055102,
-0.009901704,
-0.007897311,
0.012995152,
-0.025682963,
-0.023103977,
-0.017491674,
-0.0008685706,
0.032978956,
-0.021527188,
0.027687356,
-0.021500463,
0.0023000417,
0.025589425,
-0.014805787,
-0.027313203,
0.023384592,
0.018827938,
0.01889475,
-0.012707856,
-0.017531762,
-0.00005684335,
0.026778698,
0.007883948,
0.024025997,
-0.022529384,
0.012367109,
0.044337187,
-0.014859238,
0.0046201274,
-0.0039954246,
0.00047186765,
0.00901309,
-0.011324824,
0.017986093,
0.019856859,
-0.03468937,
0.011678933,
0.0057225437,
-0.0032421066,
-0.032765154,
-0.038270555,
0.013269085,
0.019282266,
-0.007042103,
-0.0029481289,
-0.013843678,
0.017812377,
0.0045633363,
0.017919278,
0.026404545,
0.00048021929,
0.015727809,
0.0036747216,
0.02902362,
-0.019322354,
-0.0071890918,
0.0068951137,
0.005518764,
0.013736777,
-0.0082581015,
-0.0065610483,
0.006257049,
-0.009614408,
-0.015674358,
0.03305913,
0.0037749412,
0.03126854,
-0.0014849216,
0.0052949395,
0.021006044,
-0.024547141,
-0.014952776,
0.01568772,
-0.03212375,
0.02846239,
-0.011478494,
-0.0027560412,
-0.015420468,
0.0070755095,
-0.032711703,
-0.010556472,
-0.018948201,
0.009921748,
0.012159987,
0.012580911,
-0.021460375,
0.0032788538,
-0.011451769,
-0.03859126,
0.0073360805,
-0.008071025,
-0.007088872,
0.00056540605,
0.0062770927,
0.00840509,
-0.6367023,
0.003728172,
-0.009694584,
-0.006086675,
0.002577316,
0.01538038,
-0.015193303,
-0.013115415,
0.0018523937,
0.018707674,
-0.02856929,
0.010870495,
0.014672161,
-0.031428892,
-0.033647086,
-0.014418271,
-0.0022616242,
-0.0027694039,
0.03132199,
0.00519472,
-0.018467147,
0.00006174994,
-0.02750028,
0.03273843,
0.030653859,
0.0074363,
0.009821529,
0.007736959,
-0.023798833,
0.024106173,
-0.007870586,
0.006614499,
-0.032872055,
-0.0096678585,
0.04449754,
0.011037528,
-0.0012794712,
0.027326565,
-0.004700303,
0.0541988,
-0.02795461,
-0.012714537,
0.023010438,
0.0043161274,
-0.012794713,
0.014685524,
0.00044514242,
-0.013382668,
0.004750413,
-0.007817135,
0.010168957,
0.011578714,
-0.02077888,
-0.008952958,
-0.022449208,
-0.003574502,
0.018868025,
-0.012981789,
0.033166032,
-0.0034442162,
0.0058795544,
-0.0047905007,
0.0026007006,
-0.018239982,
-0.004292743,
-0.00024282394,
-0.021340111,
-0.0075966516,
0.013977305,
-0.011719021,
0.01864086,
0.0296383,
0.012560867,
-0.001583471,
0.016716642,
0.024961382,
0.0018139762,
0.005612302,
-0.0015550754,
0.01624895,
-0.032070298,
-0.016262313,
-0.03519715,
0.0028746345,
0.011177835,
0.010122187,
-0.014605348,
0.025696326,
0.009480782,
-0.005765972,
-0.0011926142,
0.013375986,
0.007456344,
-0.036132537,
-0.027981335,
-0.0122735705,
0.0044798194,
0.004242633,
0.024106173,
0.0011057571,
-0.017585212,
0.0018874706,
0.012186713,
-0.010396121,
0.021968154,
0.01359647,
-0.026083842,
0.028756367,
0.018774487,
-0.025228634,
-0.020912506,
-0.018988289,
0.011411681,
-0.009514188,
-0.009393925,
-0.02800806,
-0.015914885,
0.00432949,
-0.01538038,
-0.02724639,
-0.0031235134,
-0.021821165,
-0.00809775,
0.013676645,
0.003402458,
-0.004018809,
-0.014591985,
-0.017331323,
-0.0019927013,
-0.0038617982,
0.013228998,
-0.0019943716,
0.007169048,
-0.018199895,
0.0036680403,
0.023464767,
0.013977305,
0.0008552079,
0.0029514695,
-0.017411498,
0.0045800395,
0.024587229,
0.013409393,
0.003815029,
0.0053550717,
-0.017037345,
-0.0048873797,
-0.013937217,
-0.0063372245,
-0.025696326,
-0.0059864554,
-0.019629695,
0.00575595,
0.01201968,
0.02918397,
-0.013349261,
-0.029905552,
-0.01909519,
-0.0033022384,
-0.028489115,
-0.0018039542,
0.037442073,
-0.022288857,
0.017558487,
-0.030092629,
-0.03559803,
-0.0011951197,
0.013710052,
-0.0034843043,
-0.025589425,
0.023598393,
-0.007329399,
-0.0046268087,
0.01023577,
-0.012420559,
0.0062603895,
-0.0029264146,
-0.019015014,
-0.023705294,
-0.004205886,
-0.011939504,
-0.029932277,
-0.0101890005,
0.004509886,
0.03132199,
0.036640316,
0.013569744,
0.0077570034,
-0.0072492235,
0.0122067565,
-0.0053483904,
0.011278055,
-0.033166032,
0.013402712,
0.0051980605,
-0.012767987,
0.025629513,
0.012460647,
0.004386281,
0.028783092,
0.031535793,
-0.012661086,
-0.011585395,
-0.013409393,
0.02755373,
-0.025402348,
-0.00094290014,
-0.015139853,
0.00697529,
0.015821347,
-0.00835164,
0.011024165,
0.0057726535,
-0.026057117,
-0.005719203,
0.0029965683,
-0.014792425,
-0.014431634,
-0.014298008,
-0.0031034695,
-0.0046368307,
-0.01650284,
0.02505492,
0.02505492,
0.007964124,
0.0376826,
0.0176253,
-0.00006681312,
0.004463116,
-0.030573683,
0.011886054,
0.02342468,
0.0037949851,
0.00069736195,
0.017892553,
-0.019389167,
0.011926142,
0.0054920386,
0.017451586,
0.02210178,
0.020003848,
0.028783092,
0.034609195,
-0.016489478,
0.0063739717,
0.00072951574,
0.018467147,
0.011157791,
-0.002470415,
-0.014097569,
-0.015514007,
-0.004155776,
-0.022395758,
-0.0011466802,
0.0031736232,
-0.027005862,
-0.013416074,
-0.0063940156,
0.019389167,
0.029611574,
0.0012644383,
-0.0044430722,
0.008652299,
-0.019749958,
-0.00082263653,
0.008832694,
0.0021263275,
0.00013832403,
-0.008204651,
-0.017705476,
-0.018547323,
0.005495379,
0.014591985,
-0.0071222787,
0.032257374,
0.0019375804,
0.0062770927,
0.029985728,
0.02007066,
-0.0013872074,
-0.03172287,
-0.026244193,
0.0161955,
0.013776865,
-0.005418544,
0.0030082606,
-0.010629968,
-0.016382577,
-0.013436118,
0.012427241,
0.010489659,
0.017023982,
0.0054051816,
-0.0020361298,
-0.008244739,
-0.024106173,
0.030573683,
-0.013041921,
0.011825922,
-0.021941429,
0.012099856,
0.0025956896,
-0.02469413,
-0.021674177,
0.027633905,
0.015741171,
0.0037148094,
-0.02489457,
0.019843496,
-0.002877975,
0.0067548063,
-0.012046405,
-0.008064344,
-0.033807438,
-0.019803409,
-0.0027176237,
-0.012540823,
0.009687902,
0.03701447,
-0.0014239546,
0.0010305924,
-0.025843315,
-0.018239982,
-0.002831206,
0.03875161,
0.035170425,
0.0025405688,
0.02342468,
0.0010740209,
-0.02184789,
0.0043361713,
-0.016943807,
0.024440238,
-0.0065109385,
0.0026140632,
0.008498629,
0.010329308,
-0.0110575715,
0.015193303,
0.022395758,
-0.0073160366,
-0.03305913,
-0.004489842,
-0.023972547,
-0.0026925688,
0.005411863,
0.022315582,
0.02083233,
0.018761124,
-0.017611938,
0.013569744,
0.02047154,
-0.0013988997,
-0.0041290508,
-0.012995152,
0.013830315,
0.022850087,
0.013108734,
-0.0048239073,
-0.017438224,
0.004195864,
0.0140307555,
0.0118593285,
0.008665661,
0.017090796,
0.033379834,
0.00005710434,
-0.0013354273,
0.00916676,
-0.013776865,
-0.0020661957,
-0.018213257,
-0.009808166,
-0.017304597,
0.033139307,
-0.010670056,
-0.024306612,
-0.004212567,
-0.0031034695,
0.010850451,
-0.0038818424,
-0.021700902,
0.0042760395,
0.0051980605,
0.0013103723,
-0.014792425,
-0.013923855,
-0.005087819,
-0.003131865,
-0.018386971,
-0.000004038801,
0.009500826,
-0.02668516,
-0.008418453,
0.001960965,
-0.024854481,
-0.038831785,
-0.0021146352,
0.02494802,
0.01864086,
0.0074162562,
-0.0045499736,
0.005672434,
0.036854118,
-0.004222589,
-0.016997257,
-0.00058628514,
-0.027767533,
0.011872691,
0.009454057,
0.012420559,
-0.0014523502,
-0.009180123,
-0.02001721,
0.023972547,
-0.017077433,
0.005241489,
-0.004853973,
-0.020124111,
0.02536226,
0.0076768273,
0.038537808,
0.004215908,
-0.010857132,
0.0057926974,
-0.03701447,
-0.023705294,
-0.0202711,
-0.029771926,
-0.021594001,
0.014859238,
0.013536338,
-0.016382577,
-0.0019008332,
-0.010335989,
-0.019282266,
0.021500463,
0.011070934,
0.022903537,
0.048051994,
-0.00064057077,
0.024239799,
0.0044865008,
0.025415711,
0.0075565637,
-0.025522612,
0.016115325,
0.007650102,
-0.023438042,
0.020538352,
0.0142044695,
0.00045516438,
-0.019028377,
0.014805787,
0.0058895764,
0.053557396,
0.0055722143,
-0.03386089,
-0.006591114,
-0.04807872,
0.0066679493,
0.012086493,
-0.005595599,
-0.012220119,
-0.014538535,
-0.00402215,
-0.008572123,
-0.030119354,
0.031856496,
-0.040061146,
0.010776957,
0.008218014,
0.006798235,
0.011618801,
0.0024487008,
-0.0004985929,
-0.010456253,
-0.023651844,
-0.030546958,
-0.030947836,
-0.0011700648,
-0.033192758,
0.034609195,
0.026765335,
0.03835073,
0.005689137,
-0.02113967,
0.012714537,
0.0032521286,
0.018386971,
-0.00356448,
0.02735329,
-0.0041223695,
0.027152851,
-0.005912961,
-0.0068951137,
0.019562881,
-0.025268722,
0.015153215,
0.013569744,
0.007022059,
-0.008358321,
0.013469525,
-0.011932823,
-0.030279705,
0.011645527,
0.007149004,
0.008618892,
-0.028756367,
-0.0018039542,
0.015473918,
-0.008017574,
0.017986093,
0.009534232,
0.018306796,
-0.020030573,
0.0061902357,
-0.004289402,
0.012420559,
0.012186713,
0.010115506,
-0.0079106735,
-0.012180031,
0.020244375,
0.014658798,
0.009888342,
-0.0107970005,
0.011652208,
-0.00013947238,
0.005097841,
-0.026457995,
-0.005278236,
-0.012968427,
-0.014431634,
-0.02795461,
-0.016008424,
-0.0065009166,
-0.041584484,
-0.0065209605,
0.026524808,
-0.0002549338,
0.026311006,
-0.014899326,
-0.004406325,
-0.0017555148,
-0.0244536,
0.02063189,
-0.02063189,
0.0256696,
0.03581183,
0.015594183,
-0.023397954,
-0.04121033,
0.0012251856,
0.0033323043,
0.033326384,
0.008879463,
0.0022532726,
-0.025776502,
0.021019407,
0.014097569,
-0.015099765,
-0.03880506,
0.02693905,
-0.010957352,
-0.02317079,
-0.0071155974,
-0.0137902275,
-0.030653859,
0.024279887,
-0.014177744,
-0.0011934494,
-0.00034053813,
0.0005357577,
-0.0073828497,
0.025469162,
0.0012711196,
0.0151799405,
-0.009099947,
0.019856859,
-0.011131066,
-0.009006409,
-0.02240912,
0.005999818,
0.0024988106,
0.034555744,
0.010877176,
-0.015246754,
0.008037618,
0.0109707145,
-0.004643512,
-0.015914885,
0.0030416672,
0.03976717,
-0.012754625,
-0.015046314,
0.01793264,
0.014738974,
0.0047170063,
-0.03386089,
-0.016436027,
-0.017638663,
-0.021006044,
-0.012012999,
0.017718839,
0.0012694492,
0.00427938,
-0.021473737,
-0.019268904,
0.0008752519,
-0.031402167,
-0.01675673,
0.006096697,
-0.025295448,
0.008177926,
0.011324824,
0.013402712,
-0.0010498011,
-0.011572032,
0.030787485,
0.004853973,
0.04393631,
-0.00850531,
0.011478494,
0.006283774,
0.021006044,
-0.034716096,
0.0010330979,
-0.01318891,
-0.014966139,
-0.004884039,
-0.025121734,
-0.021981517,
0.0063472465,
-0.0072091357,
0.021072857,
0.0036446557,
-0.024613954,
0.024881206,
0.016489478,
0.023691932,
-0.00063180155,
-0.015300204,
0.0062236423,
-0.025976941,
0.000120889985,
0.008184607,
-0.016462753,
-0.031348716,
-0.018921476,
0.006029884,
0.011892735,
-0.03947319,
-0.0087992875,
-0.0012661086,
0.0032705022,
0.0034943263,
0.0038818424,
-0.0031686123,
-0.008852738,
-0.023999272,
0.017531762,
0.014444997,
-0.011070934,
-0.016516203,
0.0050143246,
0.012180031,
0.0044330503,
-0.015741171,
0.0187344,
-0.0021898,
-0.036079086,
-0.03717482,
-0.0026341071,
-0.016275676,
0.01425792,
0.022529384,
-0.014444997,
0.005314984,
0.010736869,
-0.046582107,
-0.021219848,
0.008037618,
0.023291053,
0.0127278995,
0.021861253,
0.0055020605,
-0.032257374,
-0.007002015,
0.040114596,
-0.03223065,
-0.0004756259,
0.009514188,
-0.013776865,
0.0032404363,
0.012828119,
-0.033647086,
-0.009407287,
0.022315582,
-0.0039787213,
-0.001777229,
0.011344868,
-0.0009746364,
0.030119354,
-0.006955246,
0.010315945,
-0.011972911,
0.0068884324,
-0.0009946803,
-0.02719294,
-0.004339512,
0.018547323,
-0.0039486554,
-0.020965956,
-0.014124294,
0.01757185,
0.0101890005,
-0.012961745,
-0.03092111,
0.0045199078,
0.016743368,
-0.0030717333,
0.004670237,
0.0077570034,
-0.0037315127,
0.00087358156,
0.01929563,
-0.002928085,
-0.015260116,
-0.0010765264,
-0.019429255,
-0.010676737,
-0.008952958,
-0.001573449,
0.00769019,
0.007817135,
0.02464068,
-0.030333156,
0.0077570034,
-0.00020983495,
-0.00018519761,
-0.013255723,
-0.00037436225,
0.0054152035,
-0.014231195,
-0.013910492,
0.013830315,
-0.00519472,
-0.0201642,
-0.0187344,
-0.006758147,
-0.011291417,
0.010215726,
-0.004847292,
0.015848072,
-0.009153398,
-0.020030573,
0.009079903,
0.004857314,
0.010609924,
0.18151788,
-0.015981698,
0.0066946745,
0.0065777516,
-0.012667768,
0.0015826358,
0.02617738,
0.0065877736,
0.008117794,
-0.009186804,
-0.0028345466,
0.0005061094,
-0.012767987,
-0.0026908985,
0.02204833,
-0.018560685,
-0.0074229375,
-0.0044931825,
-0.011825922,
-0.015059677,
0.0021814483,
-0.023464767,
0.022582835,
-0.005749269,
0.012808075,
0.01929563,
-0.025843315,
0.0066278614,
0.00926698,
0.017558487,
-0.024012635,
0.02224877,
0.011872691,
-0.012921657,
0.012694493,
0.0045800395,
0.012106537,
-0.008291508,
-0.008438497,
-0.014899326,
0.00069527404,
0.014391546,
-0.013516294,
0.0131621845,
-0.0014381524,
0.03752225,
0.010950671,
-0.010302583,
-0.01364992,
-0.012400515,
-0.034662645,
0.003065052,
0.002465404,
0.008745837,
-0.009534232,
-0.016689917,
0.008552079,
0.017331323,
0.030039178,
0.037361898,
-0.017157609,
0.013195591,
-0.027927885,
0.039072312,
-0.018560685,
0.035544578,
0.008191288,
0.010262495,
0.017277872,
-0.0043829405,
-0.0042092265,
0.011979592,
-0.023504855,
0.011739065,
-0.017491674,
-0.010215726,
0.03819038,
0.022890175,
0.019255541,
0.007369487,
0.0072224983,
-0.016115325,
-0.0128348,
0.0030967882,
-0.0071222787,
-0.027420104,
0.02913052,
0.012113218,
-0.01558082,
0.006651246,
0.017611938,
0.008959639,
-0.0030767443,
-0.026003666,
-0.009915067,
-0.008304871,
0.021353474,
0.017758926,
-0.020925868,
0.0044597755,
-0.04978914,
0.058528293,
0.021727627,
-0.01359647,
-0.005478676,
0.019215453,
-0.012139943,
0.0297452,
-0.016235588,
-0.009099947,
0.019950397,
0.011010802,
0.0074630254,
-0.014351458,
0.011351549,
0.035892006,
0.0053951596,
-0.035731655,
0.044363912,
0.00090114196,
0.0037649192,
-0.031482343,
0.0097547155,
0.01375014,
0.014284645,
-0.022489296,
-0.030894386,
0.025121734,
-0.020805605,
-0.01914864,
-0.0029364366,
-0.004292743,
-0.01268113,
0.00006660433,
-0.009808166,
-0.00560228,
0.002592349,
0.0048038634,
-0.025335535,
0.000015737622,
-0.0065677296,
-0.015527369,
0.0068683885,
0.0049207862,
-0.012894932,
-0.019977123,
0.01970987,
0.026311006,
-0.008685705,
-0.02199488,
-0.018199895,
-0.019883584,
0.012233482,
-0.025749777,
0.0111444285,
-0.053236693,
-0.024306612,
-0.0374688,
-0.008071025,
0.0017488335,
-0.030466782,
-0.012620999,
0.0017571851,
-0.008071025,
0.001970987,
-0.003233755,
-0.16836905,
0.0033807438,
0.012086493,
-0.02755373,
0.03295223,
0.011745746,
0.0047136657,
-0.0047537535,
-0.01364992,
0.004603424,
0.01833352,
0.027326565,
-0.039125763,
-0.03193667,
0.01003533,
0.020418089,
-0.031402167,
0.023651844,
0.010863814,
-0.00089696614,
0.016890356,
-0.023705294,
0.026925687,
-0.008926232,
0.011070934,
0.010088781,
-0.002244921,
-0.0297452,
0.011645527,
-0.03639979,
-0.018453784,
-0.007770366,
0.019335717,
-0.008959639,
0.021834528,
0.00769019,
0.018961564,
-0.0010330979,
0.009133354,
0.037254997,
-0.0020277782,
0.039553367,
-0.03835073,
0.004453094,
0.010416165,
0.0109707145,
-0.014137656,
-0.02210178,
0.014805787,
0.009053178,
0.032765154,
-0.00229169,
-0.013476206,
0.030065903,
0.047437314,
-0.0039753807,
0.0011299769,
0.013262404,
0.010556472,
-0.0014498447,
0.0029414475,
-0.011117703,
0.030413331,
0.002016086,
0.0068182787,
-0.047758017,
-0.010122187,
-0.000006557342,
-0.032391,
-0.0063104993,
-0.018052906,
0.006604477,
0.00011681856,
-0.027687356,
0.02790116,
-0.006614499,
-0.0037548973,
0.0059864554,
0.015807984,
0.006534323,
-0.019816771,
0.011779153,
-0.017732201,
-0.017398136,
-0.009975199,
-0.0017555148,
0.020030573,
0.024907932,
0.009400606,
0.006343906,
0.0013771855,
-0.028061511,
0.011498538,
-0.017491674,
0.018346883,
0.002194811,
0.011518582,
-0.00835164,
0.010609924,
-0.009160079,
0.012540823,
-0.011070934,
-0.017732201,
-0.0017028993,
0.020538352,
-0.014057481,
-0.008037618,
0.022288857,
0.04369578,
-0.0019025035,
-0.015647633,
-0.0035878646,
0.008418453,
0.040221497,
0.0051880386,
0.02856929,
0.006764828,
0.014939413,
0.017358048,
-0.015086402,
0.048720125,
-0.014391546,
-0.00095208694,
0.026604984,
0.011752428,
-0.009634452,
-0.12838809,
-0.024600592,
0.009895023,
0.016970532,
-0.0012276911,
0.008652299,
-0.0048406105,
0.022890175,
-0.019790046,
0.03824383,
-0.02550925,
-0.02790116,
-0.0072091357,
-0.00682496,
0.016876994,
-0.00072659267,
0.016128687,
0.007215817,
-0.023264328,
0.03808348,
-0.007362806,
0.00376826,
-0.0050911596,
-0.006708037,
-0.017398136,
0.010489659,
-0.03182977,
0.009400606,
0.0145518975,
0.013489569,
0.03594546,
-0.023798833,
0.017464949,
-0.0028579312,
-0.029451223,
0.022569472,
-0.0028245247,
-0.023331141,
0.01782574,
-0.016208863,
-0.00031673594,
-0.005351731,
0.011779153,
0.030012453,
-0.0019592948,
0.0018106356,
-0.018600773,
-0.0039085676,
-0.018360246,
-0.03594546,
-0.03273843,
-0.014485084,
0.0009529221,
0.034101415,
0.011592076,
-0.012440603,
0.017692113,
-0.0050711157,
-0.023812195,
-0.030359881,
0.005134588,
0.0008794277,
-0.029985728,
0.017411498,
0.023264328,
-0.021527188,
-0.034315217,
-0.027473554,
0.0101890005,
-0.03166942,
-0.01817317,
0.021660814,
0.003382414,
-0.0072893114,
-0.04802527,
0.0022432504,
-0.008385046,
0.0024403492,
0.017224422,
0.01339603,
-0.012868207,
-0.01247401,
0.029665025,
-0.019509431,
0.023758745,
0.032711703,
0.015848072,
-0.0037014468,
-0.0014423282,
-0.0059964773,
-0.005314984,
0.012607636,
-0.026898962,
-0.01701062,
-0.008518673,
0.026284281,
-0.014124294,
0.0033941064,
0.021874616,
0.018961564,
-0.01588816,
-0.019228816,
-0.050858147,
0.0006259554,
0.0053483904,
-0.026244193,
0.024199711,
-0.012213438,
0.0030867662,
0.013102053,
0.003982062,
-0.0050711157,
-0.015086402,
-0.016676554,
-0.022008242,
-0.012707856,
-0.015794622,
-0.013175547,
0.040274948,
-0.0016811851,
0.018854663,
0.041931912,
-0.0027309863,
-0.007830498,
-0.0010372737,
0.010950671,
-0.010048693,
-0.006487554,
0.0068884324,
0.013576426,
-0.001497449,
-0.021861253,
-0.021781078,
-0.041183606,
-0.004038853,
0.011064253,
0.003992084,
-0.01706407,
0.010416165,
0.016382577,
0.028943444,
0.021660814,
-0.025803227,
-0.021166395,
0.009400606,
-0.0009203507,
0.011398318,
-0.0014899325,
-0.014244557,
0.0066278614,
-0.03081421,
-0.0054719946,
0.03116164,
0.003941974,
0.01934908,
-0.012420559,
-0.021928066,
0.014217832,
-0.006955246,
0.0005867027,
-0.015821347,
-0.006400697,
0.029959003,
0.010222407,
0.010509703,
0.0001875987,
-0.002383558,
-0.033192758,
-0.0269925,
-0.021019407,
0.0029598211,
-0.03570493,
-0.025402348,
-0.007903992,
0.014351458,
0.0075298385,
-0.010516385,
-0.005077797,
0.003641315,
0.011177835,
-0.0012210098,
0.031241816,
0.016342489,
0.004242633,
-0.020244375,
0.014952776,
0.021527188,
0.028114961,
-0.009293705,
0.02311734,
-0.019696508,
0.0049074236,
-0.0037716005,
0.024480328,
-0.0019592948,
0.010482978,
-0.007670146,
0.01568772,
-0.00932043,
0.0060131806,
-0.00063639495,
-0.005692478,
0.0100821,
0.00967454,
0.020538352,
-0.04182501,
-0.014137656,
0.030894386,
-0.038617983,
-0.0321772,
-0.012026361,
0.019990485,
-0.0071824105,
-0.01349625,
-0.009307068,
0.012086493,
-0.01115111,
0.005912961,
0.006437444,
-0.054572955,
-0.017077433,
0.03819038,
0.0038885237,
0.004593402,
0.0065209605,
-0.012333702,
0.015848072,
-0.005314984,
0.03025298,
-0.0060332245,
0.025629513,
-0.0035778426,
0.021954792,
0.012113218,
-0.024239799,
-0.024921294,
0.009781441,
-0.027313203,
-0.009086585,
-0.018146444,
0.004349534,
0.08135165,
0.0065577077,
-0.019522794,
0.017758926,
-0.0140307555,
0.029985728,
0.010255814,
0.026524808,
0.0068015754,
-0.019896947,
0.017144246,
-0.030386606,
0.035170425,
-0.037709326,
-0.0160886,
0.026658434,
-0.0053383685,
0.03212375,
-0.025121734,
-0.014912688,
0.028302038,
-0.022783274,
0.012380471,
0.0060933563,
-0.030012453,
0.006150148,
0.025482524,
-0.0062770927,
0.009601045,
-0.0032938868,
0.008144519,
-0.013008514,
-0.04735714,
0.006794894,
-0.016235588,
0.024533778,
0.00004802193,
-0.022809999,
-0.0008952958,
0.015447193,
0.0012276911,
0.011070934,
0.0005875379,
-0.02429325,
-0.00023113163,
0.011759109,
-0.023184152,
0.010776957,
-0.02856929
] |
Debate exists over how to incorporate information from multipartite sequence data in phylogenetic analyses. Strict combined-data approaches argue for concatenation of all partitions and estimation of one evolutionary history, maximizing the explanatory power of the data. Consensus/independence approaches endorse a two-step procedure where partitions are analyzed independently and then a consensus is determined from the multiple results. Mixtures across the model space of a strict combined-data approach and a priori independent parameters are popular methods to integrate these methods. We propose an alternative middle ground by constructing a Bayesian hierarchical phylogenetic model. Our hierarchical framework enables researchers to pool information across data partitions to improve estimate precision
|
[
-0.023319187,
0.017076692,
0.003090035,
-0.022472981,
-0.018186469,
0.022445237,
0.016369209,
0.011361341,
-0.01982339,
-0.042532198,
-0.010529008,
0.040645577,
-0.017215414,
0.026801111,
-0.0075326106,
0.004536213,
0.034541804,
0.015314921,
0.01273469,
0.0048760823,
-0.013997061,
0.014184335,
0.009932503,
-0.03445857,
0.008864343,
0.034902483,
0.017451242,
-0.020156322,
-0.014198208,
0.0008488059,
0.031906087,
-0.003752433,
-0.008899024,
-0.029520065,
-0.017368007,
-0.016535675,
-0.004522341,
-0.0005678936,
0.028077355,
-0.019865006,
0.0207667,
-0.018616507,
-0.030962775,
-0.011125513,
0.009051617,
-0.0053442693,
0.0031195134,
-0.025954906,
-0.035096694,
0.0051153777,
0.02904841,
0.020669594,
-0.027869271,
0.0126375845,
-0.013414428,
0.006582364,
-0.017548347,
0.004917699,
0.000013994135,
-0.009877014,
-0.0030380143,
0.022736553,
-0.015328793,
0.001185207,
-0.03418113,
-0.020225683,
-0.0008947576,
-0.012540478,
0.014496461,
0.016840864,
0.024359602,
0.028632244,
-0.0058263284,
-0.0027727082,
0.015134582,
-0.005313057,
-0.0139277,
-0.025830057,
-0.029159388,
0.01173589,
0.0070089344,
-0.017576091,
0.015800448,
0.02265332,
0.02390182,
-0.013143919,
0.019795645,
0.0091625955,
0.009682803,
-0.012609839,
0.005326929,
0.015994659,
0.001112378,
-0.0031385878,
-0.033182327,
0.00673149,
0.008330262,
0.014101102,
-0.0074216328,
-0.0004530144,
-0.021002527,
0.0074355053,
-0.02979751,
-0.012505799,
-0.024664791,
0.0005219419,
0.008912896,
-0.018297447,
0.019865006,
0.013379747,
-0.013948509,
0.04283739,
0.0029391747,
-0.027897017,
0.01120181,
-0.016979586,
0.016424697,
0.01264452,
-0.030602098,
0.0059546465,
0.014163528,
-0.026287839,
0.010861942,
-0.0045847655,
0.04247671,
0.023291443,
-0.0077268216,
-0.016396953,
-0.0073453356,
-0.005455247,
0.0036761358,
0.0050911014,
-0.019268502,
0.026856601,
-0.026204607,
0.0034975312,
-0.005261036,
-0.024012797,
-0.01800613,
-0.035734814,
0.0030501524,
0.0022663726,
-0.002236894,
-0.030213675,
-0.008552218,
0.034486316,
0.017714813,
0.021002527,
-0.022930766,
-0.024928363,
0.023485653,
-0.0021380545,
0.015287177,
0.0070054666,
0.030851796,
-0.002897558,
-0.0035790305,
-0.0035929026,
-0.005243696,
0.010542881,
-0.02653754,
-0.008212348,
0.010092033,
0.006842468,
0.03074082,
0.033543006,
-0.0057569677,
-0.021363204,
0.009655058,
-0.016466314,
-0.013948509,
0.021418694,
-0.018561019,
0.009835398,
-0.008267838,
0.000411181,
-0.0019611837,
0.016133381,
-0.028313182,
-0.0437807,
0.01971241,
-0.006967318,
0.0016317188,
0.012866476,
0.00043480712,
-0.023860203,
0.009655058,
-0.0008011202,
0.015717216,
-0.0061384533,
0.005458715,
-0.019726284,
0.001712351,
0.002053087,
-0.64278275,
-0.015925298,
0.01129198,
-0.0524647,
0.0067973835,
0.009148723,
0.012172865,
-0.001711484,
-0.010723219,
0.028063484,
-0.009530209,
0.02591329,
0.018477784,
-0.022708809,
-0.02227877,
-0.022042943,
0.0064817904,
-0.03262744,
-0.008129115,
0.007158061,
-0.04189408,
0.018172596,
0.010716283,
0.02516419,
-0.016951842,
-0.0053616096,
0.034292106,
0.0074355053,
-0.002555955,
0.0070678913,
-0.028826455,
-0.0001382886,
-0.0016950108,
-0.005014804,
0.046638373,
-0.0011938772,
-0.007109508,
0.028576754,
0.032211274,
0.022861404,
-0.019975984,
-0.020600233,
0.01982339,
0.028327055,
-0.014385482,
0.00931519,
0.01568947,
-0.0009025607,
0.012720818,
-0.010105906,
0.002699879,
-0.012512734,
-0.009211148,
-0.0055315443,
0.010404158,
-0.0076089078,
0.02698145,
-0.029714275,
0.017423498,
-0.0057569677,
-0.010563688,
0.003291182,
-0.009661995,
-0.019906623,
-0.019559817,
-0.0029825254,
-0.0064748544,
-0.028659988,
0.015106837,
-0.030657586,
0.003291182,
0.016202742,
0.009911695,
-0.03093503,
0.013983188,
0.009488592,
0.027522467,
0.0064991307,
-0.01971241,
0.011597169,
0.02441509,
0.0035339457,
-0.014912627,
0.0002120931,
0.03576256,
0.0017713079,
-0.0058055203,
0.012859539,
-0.0026530602,
-0.009904759,
0.02347178,
0.0071511245,
0.01681312,
-0.03362624,
-0.014787776,
0.017215414,
-0.0047581685,
-0.014510333,
-0.014940371,
-0.037982114,
-0.002887154,
-0.013476853,
0.010861942,
-0.011347469,
0.008843535,
0.014329994,
0.010848069,
-0.012013335,
0.029936232,
0.0025889014,
0.0011080429,
-0.010702411,
0.0029998657,
-0.0044391076,
-0.0009961982,
-0.037954368,
0.012186738,
-0.0034559146,
-0.01756222,
-0.03418113,
0.006166198,
-0.019171396,
0.019226884,
-0.025954906,
-0.015772704,
0.008885151,
-0.004664531,
-0.016230486,
0.0029357066,
0.0086285155,
-0.015079093,
-0.021293843,
0.028965177,
-0.01195091,
0.007685205,
-0.0033189266,
0.013414428,
0.00885047,
-0.015453643,
-0.031822853,
-0.037926625,
-0.0015311453,
-0.0029877275,
-0.006693342,
-0.026260095,
-0.02372148,
-0.017853536,
-0.0028368672,
0.01512071,
-0.004338534,
-0.0039050274,
0.0054899273,
0.00028611434,
-0.013594767,
0.008885151,
0.0065927682,
0.012138184,
-0.03268293,
-0.008295582,
-0.022112304,
-0.00015161894,
0.021654522,
-0.017936768,
0.0052263555,
0.005926902,
-0.017603835,
-0.0027727082,
-0.020544745,
-0.00016603303,
0.0035339457,
0.01718767,
-0.03784339,
0.005195143,
0.00878111,
0.002373882,
0.0052402276,
-0.008718684,
-0.021654522,
-0.011520871,
-0.017229285,
0.007775374,
0.0066239806,
0.005802052,
-0.005916498,
0.033792704,
-0.009003065,
0.013227154,
-0.013324259,
-0.0009537145,
0.026759494,
0.021945838,
0.01987888,
0.00026487253,
0.01499586,
-0.00865626,
0.0064158975,
0.014649055,
0.0024571153,
0.012193673,
0.03551286,
0.028881943,
0.0024467113,
0.0033848195,
-0.02146031,
0.020156322,
-0.022417493,
0.01806162,
-0.02240362,
0.00028936565,
0.006523407,
0.0013560086,
-0.046582885,
-0.033959173,
-0.024484452,
0.024123775,
0.02804961,
-0.008108308,
0.019365607,
-0.01202027,
0.02327757,
-0.012602904,
-0.019476583,
0.03193383,
0.021959709,
-0.010834197,
-0.029908488,
0.008510602,
0.042254753,
0.020003729,
-0.0043038535,
0.015828192,
0.032849394,
-0.0130260065,
0.010889686,
0.0365394,
-0.007275975,
0.0070054666,
-0.0006125448,
0.030352397,
-0.007990394,
-0.0074563134,
0.009856205,
0.0052922484,
-0.0002798285,
0.03248872,
-0.004602106,
0.018685868,
0.021044144,
-0.023208208,
-0.023985052,
-0.008025074,
0.005698011,
0.0018033874,
-0.011458446,
0.023041742,
-0.020364406,
0.009488592,
-0.007095636,
0.037233014,
0.023291443,
-0.017853536,
0.0017947173,
-0.008462049,
-0.0135600865,
0.014059486,
-0.03726076,
-0.016979586,
-0.012921965,
-0.005313057,
0.0040333453,
0.0017825791,
-0.015412026,
0.023097232,
-0.017118309,
0.0042310245,
-0.00856609,
0.014316122,
0.01969854,
0.0006506934,
-0.006457514,
-0.023319187,
-0.031046009,
0.021363204,
0.011923165,
-0.01681312,
-0.026523666,
-0.020919293,
-0.004716552,
-0.025067085,
-0.004473788,
0.004553553,
-0.014468716,
0.031795107,
-0.011347469,
0.0034090958,
-0.015148454,
0.023860203,
-0.0068771485,
0.006814724,
0.005659862,
-0.0064609824,
0.004976656,
-0.02509483,
-0.015953043,
0.031628642,
-0.0032114168,
-0.019989856,
-0.02548325,
0.032211274,
-0.0024744556,
0.019643052,
-0.010313989,
-0.012207545,
0.0038356662,
0.0011245161,
-0.006377749,
-0.025524868,
0.009252764,
0.054739743,
0.017201541,
0.012935837,
-0.024831258,
-0.026704006,
0.03800986,
0.043641977,
0.035734814,
-0.010438839,
-0.0022923828,
-0.0148432655,
0.00003522241,
-0.0070782956,
-0.019379478,
0.02390182,
-0.003157662,
0.0006918765,
0.0016525271,
0.002696411,
0.023249825,
0.009176468,
0.0152039435,
-0.022292644,
-0.0139277,
-0.032710675,
0.0035651582,
-0.01843617,
-0.021238355,
0.017215414,
0.037122037,
0.013795914,
0.018907823,
0.026121372,
-0.0015918362,
-0.00015660426,
-0.007428569,
-0.011638785,
0.017395753,
-0.0029287706,
0.024193136,
-0.009641186,
0.0024102966,
0.005985859,
-0.018741356,
0.011874612,
0.005659862,
-0.0011921431,
-0.007158061,
0.009772972,
-0.008004266,
-0.0035391478,
-0.01248499,
0.007504866,
0.006443642,
-0.011500062,
-0.013032942,
0.009308253,
-0.00010051934,
-0.02692596,
-0.012436437,
-0.0038703468,
-0.018144852,
-0.012561287,
-0.016854737,
-0.01157636,
-0.013906891,
-0.015481387,
-0.025358401,
0.028132843,
-0.012186738,
0.014246761,
-0.009870078,
-0.025691334,
-0.011846868,
-0.03889768,
-0.0041547273,
-0.024498325,
-0.024678662,
-0.03124022,
-0.015328793,
0.015009732,
0.020378279,
0.022153921,
-0.02019794,
-0.015231688,
0.018588763,
-0.0053165248,
-0.013497661,
-0.030629842,
-0.035485115,
-0.0026391882,
-0.00011791379,
-0.032294508,
0.00039904282,
-0.002498732,
0.006159262,
0.0018623443,
0.004827529,
0.004598638,
0.0048414017,
0.000015430125,
0.026454307,
0.0063361325,
0.008101371,
0.013386684,
-0.020184066,
-0.009828461,
-0.011222619,
-0.018352935,
-0.036040004,
0.00669681,
-0.010535944,
-0.026426561,
-0.0017357604,
0.011097768,
-0.008836598,
0.023763098,
-0.010965982,
0.011520871,
0.027536338,
0.032710675,
0.032932628,
0.015023604,
0.023971181,
-0.0028125907,
0.00023929564,
0.0037212207,
0.013761234,
0.016091764,
0.022375876,
-0.037760157,
0.022320388,
-0.00737308,
-0.0014219016,
-0.027730549,
0.0059442422,
-0.024290241,
0.051604625,
0.020059217,
-0.0023253295,
-0.015606238,
0.030629842,
-0.0046679988,
0.019975984,
-0.032960374,
0.014413227,
0.029852998,
-0.01788128,
0.002160597,
-0.00803201,
0.003034546,
-0.026107501,
-0.021321587,
0.001846738,
-0.006641321,
0.027883144,
-0.014607438,
-0.023513397,
-0.0118884845,
-0.011680402,
-0.006849404,
-0.024068287,
0.00393624,
0.0037350927,
0.039730012,
0.0152178155,
0.032766163,
-0.016896352,
0.006391621,
0.011687337,
-0.0010074694,
-0.018921696,
0.00005156019,
0.0021536606,
-0.01310924,
0.00947472,
0.005087633,
0.004827529,
-0.011590232,
0.0009459114,
0.0402849,
-0.00093117217,
-0.006471386,
-0.025150318,
-0.0018051214,
-0.038120836,
0.0040576216,
0.018963313,
0.0019663859,
0.009717484,
-0.03187834,
0.006620513,
0.012665329,
0.008142988,
0.017104436,
-0.0043558744,
0.020308917,
0.009668931,
0.034042407,
0.0031489918,
0.026662389,
-0.021654522,
-0.0120896315,
-0.027245022,
0.0102723725,
0.0071441885,
0.0070852316,
0.034430828,
-0.003088301,
-0.002632252,
-0.00048986246,
0.015855936,
-0.01699346,
0.012727753,
0.028118972,
0.0065476834,
-0.010556753,
-0.0033223946,
-0.028965177,
0.00487955,
-0.0074355053,
-0.0058367327,
-0.016605036,
-0.005326929,
-0.009440039,
-0.012158993,
0.009682803,
-0.0011765369,
0.027356,
0.0126237115,
0.01882459,
0.02007309,
-0.002770974,
-0.03431985,
0.007921033,
-0.005833265,
0.0016603302,
0.011832996,
0.02083606,
-0.0060170717,
-0.015092965,
0.009010001,
0.0026669325,
-0.007275975,
-0.020738956,
0.024165392,
0.018311318,
0.025427762,
-0.013005198,
0.010549816,
-0.016660525,
0.027203405,
-0.018699741,
0.034097895,
-0.017062819,
-0.00095804955,
0.021543544,
0.034597293,
-0.0017366274,
0.028465778,
-0.011090833,
-0.0069534457,
-0.004390555,
-0.0075464826,
-0.009592634,
-0.0031715343,
0.0029322386,
0.024082158,
0.011305852,
-0.010036545,
0.00828171,
0.017048948,
-0.009398423,
0.0047616363,
-0.02409603,
0.034874737,
-0.012575159,
0.0060274755,
-0.01763158,
-0.0049627833,
0.014857138,
-0.007192741,
-0.016285976,
-0.01950433,
-0.0091625955,
0.0039813244,
0.018602636,
0.0077476297,
0.026052013,
-0.010959047,
0.0057673715,
0.0064193658,
-0.018339062,
-0.020364406,
0.0053893537,
-0.026593028,
0.0034385743,
-0.0049281027,
-0.012346268,
0.0182697,
-0.0039050274,
0.013844467,
-0.010334797,
0.0128387315,
-0.015883682,
0.03726076,
0.025261296,
-0.011257299,
-0.038814448,
-0.00034420422,
-0.024956107,
-0.013081495,
-0.0028992922,
-0.017534474,
-0.022944637,
0.007567291,
0.02259783,
0.010522072,
0.0021952775,
0.00593037,
-0.012963581,
-0.0152039435,
0.012346268,
-0.018033873,
-0.019545944,
0.013012134,
-0.014385482,
-0.011513935,
0.007574227,
-0.0055454164,
0.029825253,
-0.030019464,
0.011520871,
-0.00036869737,
-0.034541804,
-0.017548347,
-0.0155646205,
0.03148992,
-0.036372937,
0.019851133,
0.015384282,
-0.030657586,
0.0055037998,
0.0024709876,
0.0104457745,
-0.0064297696,
0.0039743884,
-0.0017504996,
0.019268502,
0.00029370072,
-0.01586981,
-0.014940371,
-0.0027120172,
0.0011314522,
-0.012873412,
-0.01768707,
-0.018422296,
0.03620647,
0.03975776,
-0.02584393,
-0.00906549,
-0.020905422,
-0.023610502,
-0.041450165,
-0.011638785,
0.011187938,
0.00815686,
-0.0021415225,
-0.0012164195,
0.029464576,
0.0022663726,
0.008871279,
-0.021682266,
-0.009114043,
0.010542881,
-0.019726284,
0.031184731,
0.011493127,
-0.04880244,
-0.017395753,
0.025233552,
-0.011423766,
-0.0072066137,
0.0035720943,
0.006651725,
-0.0005531544,
0.0011583297,
0.011028408,
0.031212475,
-0.005535012,
0.0068702125,
-0.03864798,
-0.009689739,
0.012547415,
-0.015509131,
-0.024609303,
-0.010896621,
-0.006911829,
-0.016008532,
0.01166653,
-0.011978654,
-0.030463375,
-0.0074424413,
-0.025524868,
-0.00673149,
0.04114498,
0.019795645,
0.035873536,
0.0028750156,
0.0003331498,
-0.010175266,
-0.0013716149,
-0.01800613,
-0.0069152974,
0.013123112,
-0.013199409,
-0.002299319,
-0.0024536473,
0.0044876602,
-0.009460848,
-0.0050356127,
-0.0060760286,
0.018144852,
-0.01912978,
0.011319724,
0.028659988,
-0.014981988,
-0.011867677,
-0.005996263,
-0.012852604,
0.013289578,
0.0078655435,
-0.0067800432,
-0.010605305,
0.031600896,
-0.012776306,
-0.022112304,
-0.0006268505,
0.0074077607,
0.0036726678,
-0.010556753,
0.009981056,
0.19554268,
-0.029520065,
0.0097105475,
0.007955713,
0.018699741,
-0.005590501,
0.010542881,
0.032266762,
-0.00032274565,
0.00049072946,
0.0061315172,
0.008302518,
0.013456045,
0.0044460436,
0.038620234,
-0.019670796,
-0.02302787,
-0.02171001,
-0.021779371,
-0.002431105,
-0.0027813783,
-0.021418694,
0.012547415,
-0.017409625,
0.027688934,
-0.013469917,
-0.010105906,
-0.0024675196,
-0.012207545,
0.021418694,
-0.014649055,
-0.017576091,
-0.003696944,
0.018616507,
-0.004619446,
-0.0064054932,
-0.0056494577,
-0.0036275832,
0.018172596,
-0.0102446275,
-0.013407492,
0.0076574604,
0.00014825925,
-0.0074216328,
0.0007543015,
-0.0005795983,
0.022126177,
0.01562011,
-0.001182606,
0.004366278,
-0.034874737,
0.0007278576,
0.014926499,
0.010861942,
-0.011992526,
0.0030085358,
-0.0038703468,
0.005191675,
0.02094704,
0.02603814,
-0.018283574,
0.0069985306,
-0.001582299,
0.001054288,
-0.017326392,
0.00329465,
-0.0046541267,
0.021390948,
0.017659325,
-0.027036939,
0.03132345,
-0.030518863,
-0.03232225,
0.0038564745,
-0.009987992,
-0.030851796,
0.03495797,
0.027647316,
0.024872875,
0.020031473,
0.007629716,
0.0018952908,
-0.0073453356,
-0.0032270232,
-0.019545944,
-0.04347551,
0.03237774,
-0.022667192,
-0.01474616,
-0.004456448,
-0.0008678802,
-0.0016837396,
-0.0063118557,
-0.0048830183,
0.0215158,
0.009377615,
-0.01775643,
0.012866476,
-0.026246224,
-0.011250363,
-0.024748024,
0.0626469,
0.037621435,
0.008198476,
-0.008552218,
-0.00062641705,
-0.018047746,
-0.009585698,
0.014413227,
0.0009961982,
-0.0011279841,
-0.034902483,
0.0017158191,
-0.008358007,
0.014163528,
0.014246761,
0.03734399,
-0.015897553,
0.019032674,
-0.0100850975,
0.0024276369,
-0.043891676,
0.009169531,
0.014773904,
0.014635183,
0.0007226555,
0.010799516,
0.0062806434,
-0.028604498,
-0.012533543,
0.0077198856,
0.00043025528,
0.01875523,
0.007816991,
-0.011722018,
-0.0035460838,
-0.019532073,
-0.03223902,
-0.02220941,
0.01843617,
-0.0007820459,
-0.0046992116,
0.005184739,
0.014940371,
0.009107106,
0.013407492,
0.014704543,
0.004002133,
-0.016965713,
-0.00037931825,
-0.016272103,
0.01022382,
-0.028202204,
-0.009037745,
0.0020028003,
-0.02295851,
-0.006707214,
-0.014496461,
-0.023235952,
-0.0027813783,
-0.0067141503,
0.013830595,
0.014329994,
0.011271171,
-0.015439771,
-0.01301907,
-0.17712039,
0.0037350927,
0.023097232,
-0.017714813,
0.01437161,
0.023887947,
0.020419894,
0.024331858,
-0.007074828,
-0.0047581685,
0.031850595,
0.020003729,
-0.041949566,
-0.034097895,
0.0035720943,
0.016230486,
-0.003284246,
0.02352727,
0.015412026,
0.0190188,
0.0032530334,
-0.039175123,
0.014676799,
-0.019740157,
0.015786575,
0.013948509,
-0.0040402813,
0.01857489,
-0.013941572,
-0.035596095,
-0.012797114,
0.00828171,
0.015231688,
-0.0016048414,
0.004272641,
0.0037628373,
0.022722682,
0.0067384266,
-0.015176198,
0.0062078144,
0.022625577,
0.026676262,
0.026648518,
-0.0071511245,
0.0014227686,
0.0025923694,
-0.004012537,
0.0044425754,
0.0065997043,
0.011583297,
-0.00487955,
-0.0070609553,
0.019906623,
-0.006852872,
0.022126177,
0.0054344386,
-0.0047512325,
-0.0008479389,
-0.0014366409,
-0.02327757,
0.020655721,
0.0077268216,
0.019948239,
-0.01718767,
0.008996129,
-0.025261296,
-0.00815686,
0.0050772293,
-0.026426561,
0.00502174,
-0.012831795,
0.025982652,
0.010639986,
-0.031267963,
0.010695474,
0.013872211,
-0.018214213,
0.014940371,
-0.0044425754,
-0.01537041,
-0.012387885,
0.006204346,
-0.018727485,
-0.0013213281,
0.0025126042,
-0.010494327,
0.021751627,
0.002240362,
-0.009863142,
-0.010071225,
0.0139207635,
-0.028687732,
-0.0095094,
-0.0072274217,
0.011243427,
-0.008468985,
0.011895421,
0.0014808585,
0.025386145,
0.0077545657,
0.0016577292,
0.0117289545,
-0.011867677,
0.026842728,
0.016272103,
-0.013532341,
-0.0070262747,
-0.0072412943,
0.040950768,
-0.0072412943,
-0.011742827,
-0.00016993459,
0.0002655228,
0.014662927,
-0.008579963,
0.032211274,
-0.020544745,
-0.019282373,
0.009571825,
-0.002692943,
0.056015987,
-0.017936768,
-0.011784444,
0.011937037,
-0.0019906622,
-0.012138184,
-0.13838917,
-0.0200176,
0.0016924097,
0.009245829,
0.01310924,
0.01593917,
-0.0076089078,
0.015897553,
-0.014926499,
0.032460973,
-0.034042407,
-0.019379478,
-0.013074559,
-0.012061887,
0.019656923,
0.020794444,
-0.0075326106,
-0.016743759,
-0.013414428,
0.028438032,
0.008538346,
-0.031822853,
0.015495259,
-0.015259432,
0.009634251,
0.007574227,
-0.02692596,
0.021488056,
0.009668931,
0.008697877,
0.01568947,
-0.017936768,
-0.013740425,
-0.004286513,
-0.006984658,
-0.018838463,
-0.024997724,
-0.011527807,
0.010744028,
0.009745228,
0.00042158517,
0.008947576,
0.012138184,
0.0064991307,
-0.0065719597,
-0.0048830183,
-0.018339062,
0.021266099,
-0.0029114303,
-0.004279577,
-0.03690008,
-0.023860203,
-0.010119778,
0.01129198,
0.010563688,
0.009974119,
-0.006613577,
0.012762434,
-0.005195143,
0.019601434,
-0.018658124,
-0.004910763,
-0.004480724,
-0.013116175,
0.0066760015,
-0.014538077,
-0.04297611,
-0.02019794,
0.016854737,
-0.029353598,
-0.016646653,
0.00849673,
-0.0037350927,
0.008905959,
-0.022001326,
-0.0008236625,
-0.03839828,
-0.011458446,
0.026523666,
-0.011097768,
0.004747764,
-0.010723219,
-0.012346268,
-0.00605522,
0.003348405,
0.008045882,
0.009301318,
-0.028937433,
0.0066794697,
-0.036983315,
-0.008337199,
0.032904886,
0.001378551,
-0.011389085,
-0.01932399,
-0.0071372525,
-0.0010213415,
-0.007386952,
0.019948239,
0.012249162,
-0.02083606,
0.022861404,
-0.035596095,
0.023249825,
-0.007893288,
-0.011444574,
0.015273305,
0.010709347,
-0.0011444574,
0.0037246887,
0.00091209786,
0.021168994,
-0.01693797,
0.013851402,
-0.010515136,
-0.02057249,
-0.024526069,
-0.027245022,
0.015717216,
-0.032544207,
0.026579157,
0.0072482303,
-0.017409625,
0.012575159,
0.036095493,
0.032793906,
-0.0065338113,
-0.026426561,
-0.0054205665,
0.027466977,
-0.006634385,
0.0128109865,
0.021807116,
-0.020211812,
-0.0014392419,
0.01512071,
0.003090035,
-0.008968384,
0.015606238,
0.027897017,
0.0258578,
0.041561145,
-0.0023790842,
-0.02603814,
-0.0022819787,
-0.0058297967,
0.0005228089,
0.0016637983,
-0.014635183,
0.021252228,
-0.0065268753,
-0.015633982,
0.05382418,
0.0069499775,
0.0028455372,
-0.022417493,
-0.0032703737,
-0.0040333453,
-0.004803253,
0.009370678,
-0.0074355053,
-0.038176324,
0.03193383,
-0.008226221,
0.0148293935,
0.013227154,
-0.022722682,
-0.021571288,
-0.01713218,
0.00459517,
-0.011153257,
-0.014898755,
0.00027354265,
0.007386952,
-0.016729886,
0.0014981988,
0.011722018,
-0.0041859397,
-0.0022334259,
0.024387347,
0.02058636,
0.03884219,
0.009370678,
0.001774776,
-0.012963581,
0.00084533787,
0.026482051,
-0.0071996776,
0.009093234,
0.036372937,
-0.011000663,
-0.0026634645,
0.028826455,
0.013969316,
-0.007921033,
0.012034143,
0.0037177526,
0.030047208,
-0.011881549,
-0.0021952775,
0.0067384266,
0.03531865,
-0.010764835,
-0.008018138,
-0.0024865938,
-0.012006398,
-0.0070540193,
-0.005722287,
-0.014704543,
-0.023790842,
-0.002295851,
0.019213011,
0.010105906,
0.0215158,
0.006644789,
-0.0006259835,
0.0039015594,
0.019490456,
0.009218085,
-0.01661891,
-0.0135462135,
-0.011583297,
0.03074082,
0.021266099,
0.023194337,
-0.00056182453,
0.019115906,
0.046166718,
0.04133919,
-0.01166653,
0.030768564,
0.028410288,
0.014704543,
0.016285976,
0.03720527,
-0.014579694,
-0.0046298504,
-0.0039154314,
-0.0065130033,
0.017992258,
-0.0073245275,
0.05998344,
0.016771503,
-0.013636383,
0.007685205,
-0.023235952,
0.01668827,
0.02409603,
-0.0009329062,
0.0023530738,
-0.030629842,
-0.0038980914,
0.0076019717,
-0.02404054,
-0.01971241,
0.0035079354,
0.015328793,
-0.005600905,
0.012873412,
-0.017798048,
-0.010147522,
0.027203405,
-0.016369209,
0.019865006,
-0.005795116,
-0.029436832,
-0.0053061205,
0.011937037,
-0.00057396275,
0.0014548481,
-0.027342128,
0.008642388,
0.011208747,
-0.047221005,
-0.011083896,
-0.015051349,
0.0035720943,
-0.009120978,
-0.013712681,
0.013421364,
0.014468716,
-0.009467784,
-0.028770965,
-0.02653754,
-0.027910888,
-0.0074355053,
0.015176198,
-0.00072092144,
-0.02277817,
-0.01775643
] |
Gold standard datasets on protein complexes are key to inferring and validating protein-protein interactions. Despite much progress in characterizing protein complexes in the yeast Saccharomyces cerevisiae, numerous researchers still use as reference the manually curated complexes catalogued by the Munich Information Center of Protein Sequences database. Although this catalogue has served the community extremely well, it no longer reflects the current state of knowledge. Here, we report two catalogues of yeast protein complexes as results of systematic curation efforts. The first one, denoted as CYC2008, is a comprehensive catalogue of 408 manually curated heteromeric protein complexes reliably backed by
|
[
-0.0047856714,
-0.014556131,
0.0076213707,
-0.051111247,
-0.010443337,
0.02371551,
0.0022486476,
0.0028854783,
-0.019458527,
-0.03183124,
0.0073261284,
0.011226073,
0.024305994,
0.012558096,
-0.0041230926,
0.0062481505,
0.019829296,
-0.01860713,
-0.02166941,
-0.009571343,
-0.026338357,
0.006725345,
-0.016767016,
-0.029277049,
-0.006131427,
0.031254485,
0.015517386,
-0.03353403,
-0.013134848,
-0.012537498,
0.0061623245,
-0.006073065,
-0.013553681,
0.0012178745,
0.004627751,
-0.0013843774,
0.012152997,
0.021010265,
-0.0022314824,
0.018016646,
0.01779693,
0.022246163,
-0.010985759,
0.020708157,
-0.0048749307,
-0.010601258,
-0.0017405563,
-0.018868042,
-0.007020587,
0.018250093,
-0.0038106854,
0.021738071,
0.019925421,
0.009214305,
-0.02228736,
-0.015833225,
0.009811657,
0.01279841,
0.014913169,
-0.0051083784,
-0.015654707,
0.007175074,
-0.035044573,
0.031391807,
0.0016899188,
-0.007889149,
0.0154349925,
-0.0072780657,
0.009131912,
-0.007964675,
0.043036714,
0.028013688,
-0.0027035268,
0.01283274,
0.010292283,
-0.017261375,
-0.025926393,
-0.0069244616,
0.002615984,
0.018497273,
0.0013448973,
-0.014199094,
-0.0049401587,
0.0073810574,
0.0054242187,
0.011061287,
0.01623146,
0.0067734076,
0.011164278,
0.004813136,
0.03122702,
0.05031478,
0.020818014,
0.0001070146,
-0.04240503,
0.0020134838,
0.0028391322,
0.039301556,
-0.0033901366,
-0.014665989,
-0.023935223,
0.002959289,
-0.016203996,
-0.022685593,
-0.020076476,
-0.009447753,
0.018126503,
-0.022369754,
0.0010015923,
0.002919809,
0.018071575,
0.042597283,
-0.013999977,
-0.02628343,
0.0058842474,
-0.0012496301,
0.010621856,
-0.014350148,
-0.010443337,
-0.0034879786,
0.033506565,
0.014116701,
0.02091414,
-0.016986731,
0.029304514,
0.007703764,
-0.0063854726,
-0.00730553,
0.016945533,
-0.0058808145,
-0.001955122,
0.0065605585,
0.011610575,
0.0047891047,
-0.016904337,
0.034440357,
-0.01542126,
0.009049519,
-0.0007398222,
-0.04863945,
0.0005535793,
0.028700296,
-0.020268727,
-0.008101998,
-0.009990175,
0.021696875,
0.012503168,
0.014762115,
0.005159874,
0.018085307,
0.022493342,
0.0038793464,
0.014652257,
0.002258947,
0.0016315569,
0.011445788,
-0.001082269,
0.024484511,
-0.03065027,
-0.032792494,
-0.02272679,
0.011390859,
0.0014049757,
-0.0274644,
0.016684622,
0.028974941,
0.021930322,
-0.010312881,
0.0023722374,
-0.009839121,
-0.02610491,
0.011226073,
-0.013601744,
0.01436388,
-0.027903829,
-0.005812153,
0.0044217682,
0.0064884643,
-0.048117626,
-0.021820465,
0.023701776,
-0.009358494,
0.028205937,
0.0314742,
0.0037282922,
-0.0077518267,
0.02348206,
-0.014041174,
0.0027172589,
-0.0132172415,
0.012571828,
-0.007786157,
-0.018854309,
-0.0092761,
-0.6393712,
-0.02485528,
0.01610787,
-0.03152913,
-0.011885218,
0.020213798,
-0.002648598,
0.016506104,
0.005228535,
0.013567413,
0.005534076,
0.02447078,
-0.005712595,
-0.012496301,
-0.028810155,
-0.019321205,
0.008596357,
-0.033122066,
0.027079897,
0.015023026,
-0.025898928,
0.018620862,
-0.0037420243,
0.015146616,
0.0032253503,
-0.01910149,
0.02204018,
-0.023427133,
0.009282967,
0.010553195,
-0.013505618,
0.016890606,
-0.01785186,
-0.005637068,
0.04913381,
0.008905332,
-0.0069793905,
0.010010773,
0.03828537,
0.029661551,
-0.0069072964,
-0.0013534799,
0.018002914,
0.017645877,
-0.03652765,
0.017961716,
0.008973992,
0.014817043,
-0.017893055,
-0.01785186,
-0.009406556,
-0.041718423,
-0.012461971,
-0.018222628,
0.0135399485,
-0.012056871,
0.016657159,
-0.034742463,
0.0038999447,
0.014432541,
0.0012685119,
-0.00771063,
-0.005987239,
-0.033012208,
-0.016135335,
0.0034708134,
-0.028920012,
-0.011246671,
0.019966617,
0.015023026,
0.022438414,
0.008376641,
-0.0017379815,
0.01960958,
0.004397737,
0.015174081,
0.009955845,
0.008582625,
-0.009118181,
0.014528667,
0.00040724553,
-0.018030377,
-0.016657159,
-0.0126130255,
0.0114938505,
0.008335445,
-0.017453626,
0.024017617,
0.019252544,
0.001788619,
-0.005791555,
-0.0075389775,
-0.0030622804,
-0.011720432,
-0.019074025,
0.015091687,
0.005163307,
0.0026709128,
0.02747813,
-0.038889587,
0.0009543879,
-0.018085307,
0.005304062,
-0.0070446185,
0.005904846,
0.011885218,
-0.012262854,
0.021532089,
0.048474662,
0.015956815,
0.0124413725,
-0.0026674797,
-0.012056871,
-0.0066429516,
0.004071597,
-0.03578611,
0.022081377,
0.016904337,
-0.0061417264,
-0.0051461416,
0.006467866,
0.005228535,
0.023564454,
0.005362424,
-0.01672582,
0.0074016554,
0.0014187079,
-0.010141229,
-0.0053143613,
-0.012970062,
0.011226073,
-0.021202516,
0.016327584,
-0.021779269,
0.018305022,
0.030924913,
0.026022518,
0.002040948,
-0.013320234,
-0.028947476,
-0.018881774,
-0.025129925,
-0.014871972,
-0.0037694888,
-0.010752312,
-0.004692979,
-0.036610045,
0.00864442,
0.017755734,
0.018236361,
-0.0018555635,
-0.0043016113,
-0.0043702726,
-0.0044972952,
-0.014157898,
-0.010532597,
-0.029249584,
-0.033012208,
-0.0007132161,
-0.028068615,
0.014130433,
0.012647356,
-0.02566548,
-0.013354564,
0.014473738,
-0.02216377,
-0.006464433,
0.009839121,
-0.019637045,
-0.011308466,
0.020515906,
-0.009832255,
-0.022699326,
0.03441289,
0.014597328,
0.021257445,
-0.007209405,
-0.0010436472,
-0.019005364,
-0.013780262,
0.005654233,
-0.00050380005,
-0.017082855,
-0.006471299,
0.0181677,
0.011287868,
0.025143657,
-0.022136305,
-0.00087971904,
0.014830776,
-0.007834219,
-0.00855516,
0.012558096,
0.0097910585,
-0.025830267,
-0.01505049,
-0.0020357985,
0.0018263825,
-0.012372712,
0.028205937,
0.024209868,
-0.006052467,
-0.004116227,
-0.028054884,
-0.0014968098,
-0.020529639,
0.00057632325,
-0.0063683074,
0.0040235342,
-0.005843051,
0.0027704712,
-0.01336143,
-0.020378584,
0.00795781,
0.024086278,
0.02116132,
0.010100032,
-0.0049332925,
-0.019540919,
-0.003335208,
0.0031378076,
-0.027862633,
0.029084798,
0.0001903197,
0.009708665,
0.014926901,
0.0016607379,
0.02496514,
-0.0071132793,
0.004953891,
-0.014720918,
0.011404592,
0.0103952745,
0.006529661,
0.01592935,
0.026571807,
0.03202349,
-0.01672582,
0.04932606,
0.0072506014,
-0.012228523,
0.021738071,
0.0013800861,
0.0030468318,
0.0017937685,
-0.007442852,
0.012070604,
0.016904337,
-0.02828833,
0.011699834,
-0.01730257,
0.012324649,
-0.0226032,
-0.017453626,
-0.01404804,
0.005115244,
0.0035102936,
0.016876873,
0.052484468,
0.027423203,
-0.012970062,
-0.018922972,
-0.0036218676,
0.013684137,
0.0025696377,
0.012379577,
0.00948895,
-0.006612054,
-0.01985676,
-0.0038381498,
-0.029084798,
-0.0024666463,
0.009962711,
0.001036781,
0.005328093,
-0.003342074,
-0.0068317694,
0.00561647,
0.008774876,
-0.0017251075,
-0.030815056,
-0.04328389,
0.016025476,
0.022397216,
0.0030554144,
-0.02022753,
-0.019527188,
-0.008507097,
-0.011157412,
0.0099421125,
0.0045590904,
0.011823423,
0.0023791036,
0.008232454,
-0.004548791,
0.0022349155,
0.016066674,
-0.029304514,
-0.024690494,
0.0034484987,
-0.007909747,
-0.005551242,
0.025020067,
-0.025555624,
0.050369706,
-0.0053521246,
-0.020131404,
-0.0089945905,
-0.008665018,
-0.025116192,
0.024498243,
0.0226032,
-0.0049882215,
-0.006818037,
-0.0047170105,
-0.000781448,
-0.02110639,
0.015311402,
0.0018589965,
0.00019654211,
0.017426161,
-0.06481598,
0.008253052,
0.027423203,
0.024319725,
0.018071575,
0.000997301,
0.0036699304,
0.0043565403,
-0.004473264,
-0.03196856,
-0.010649321,
0.0022572302,
0.021957787,
-0.02147716,
-0.018442344,
0.018868042,
0.021641945,
0.026310895,
0.018909238,
0.0030708632,
-0.036417793,
-0.0013234407,
0.010951429,
0.0017972016,
-0.0020563968,
0.016327584,
0.018387415,
0.034687534,
-0.007820488,
0.031419273,
0.03976845,
0.007909747,
-0.01711032,
-0.0061554583,
0.020625763,
-0.00083165633,
0.0006415512,
-0.021422232,
-0.001853847,
0.022067644,
0.03927409,
0.009749861,
0.025061265,
0.02679152,
-0.000977561,
0.017069124,
0.00047805218,
-0.019595848,
-0.0020529637,
0.00920744,
0.0205983,
-0.015174081,
-0.040619846,
0.0043359417,
0.006670416,
-0.006210387,
-0.028508047,
0.0014435975,
-0.01311425,
-0.0033128932,
-0.019595848,
-0.013340832,
-0.019060293,
-0.002677779,
-0.008445303,
0.003707694,
-0.006148592,
-0.030210838,
0.0044663977,
-0.0173575,
-0.01785186,
-0.03751637,
-0.0041677225,
0.0041780216,
-0.02572041,
-0.023372203,
-0.01417163,
0.004675814,
0.015764564,
0.01610787,
-0.027230952,
-0.008616955,
0.011892085,
-0.030265767,
0.006138293,
0.0011732448,
-0.050864067,
-0.020529639,
0.006272182,
-0.014885704,
-0.025129925,
-0.0077930233,
0.02441585,
-0.0058087204,
-0.0056233355,
-0.0030983274,
0.0007711488,
0.007909747,
0.021820465,
0.026489412,
0.029029869,
0.00730553,
-0.040043093,
0.00030253752,
0.0023241749,
-0.0009904349,
-0.030869985,
0.009708665,
0.006268749,
-0.02054337,
-0.013615476,
0.010498267,
-0.015764564,
-0.0040372666,
-0.0072711995,
0.006677282,
0.015874423,
0.019499723,
0.029551692,
-0.020927873,
-0.0030897448,
0.0113016,
-0.01941733,
-0.0057572247,
-0.009681201,
0.033369243,
0.010017639,
-0.032572776,
0.033616424,
-0.022836648,
-0.03265517,
-0.008019605,
-0.0132172415,
-0.0042260843,
0.040345203,
-0.004758207,
-0.024031349,
-0.03303967,
-0.020268727,
0.00044457996,
0.012949464,
-0.0011234656,
-0.012166728,
-0.0018126504,
0.0020512473,
0.0026108343,
0.006615487,
-0.033836138,
-0.04100435,
-0.023344738,
-0.009900915,
0.0040475656,
0.031391807,
0.013196643,
-0.0041402583,
-0.015956815,
0.0027550226,
-0.012407042,
-0.024058813,
0.004679247,
0.011397726,
0.03990577,
0.03960366,
0.045233864,
0.012743481,
-0.008410973,
0.010113765,
0.016561033,
-0.012400176,
-0.0041093607,
0.007964675,
-0.006622353,
0.016574765,
0.009811657,
0.001082269,
0.004813136,
-0.0097910585,
0.0154349925,
0.013100518,
0.0003096182,
-0.0343305,
-0.008987725,
-0.03284742,
-0.01941733,
0.016464908,
-0.002406568,
0.002319025,
-0.03227067,
0.0008531129,
-0.007092681,
-0.005262865,
0.005328093,
0.0002815101,
0.02434719,
-0.024511976,
0.023701776,
-0.00892593,
0.014652257,
-0.010532597,
-0.004452666,
-0.02510246,
-0.011885218,
0.03864241,
-0.0022640964,
0.021998983,
-0.0010548045,
-0.004679247,
0.004061298,
0.012990661,
-0.020117672,
-0.0074016554,
-0.0181677,
-0.022630665,
-0.008562027,
-0.017508553,
-0.020323655,
-0.016011745,
0.00056130363,
-0.011116215,
-0.021326106,
0.018785648,
-0.006670416,
-0.020886675,
0.046497226,
0.0068969973,
0.033671353,
-0.020268727,
0.033808675,
0.02554189,
0.010367811,
-0.000426771,
-0.000047231257,
-0.018703256,
-0.0002252939,
0.03084252,
0.022905309,
-0.009715531,
-0.01436388,
0.01592935,
-0.012901401,
-0.010779777,
-0.050452102,
-0.0064609996,
-0.0018727287,
0.03122702,
-0.0060559,
0.004418335,
-0.0050053867,
0.008500231,
-0.024443315,
0.014597328,
0.003800386,
-0.007027453,
0.017151518,
0.018002914,
-0.03010098,
0.017769465,
-0.00052740227,
-0.020213798,
0.0020066176,
-0.01473465,
0.00089945906,
0.004476697,
-0.0069828234,
0.020680692,
0.018195163,
0.0031858704,
0.0018075007,
0.013491886,
0.0053315265,
0.0025370237,
0.0009355061,
0.03435796,
0.0045075943,
0.0008247902,
0.017783199,
0.0072643333,
0.0045865546,
-0.008019605,
-0.010271685,
-0.0060318685,
-0.014871972,
0.0015723369,
0.011349663,
-0.0011105916,
0.02035112,
-0.008857269,
-0.0053349594,
0.00771063,
-0.006615487,
0.009379093,
0.009015189,
-0.046936657,
-0.01473465,
-0.0091662435,
0.004339375,
0.01980183,
-0.007854818,
-0.001429007,
0.005561541,
0.028672833,
-0.01311425,
0.017494822,
0.018895507,
-0.019431062,
-0.041361384,
0.011521315,
-0.03240799,
-0.017426161,
0.0041642897,
-0.02559682,
-0.033973463,
0.01910149,
-0.0059632077,
0.014377613,
0.02922212,
-0.02204018,
0.008088266,
0.008101998,
0.0033180427,
-0.0074016554,
-0.008452169,
0.0045316257,
-0.02230109,
0.011528181,
0.014583596,
-0.027272148,
0.014556131,
0.008665018,
-0.01779693,
0.013018125,
-0.02815101,
-0.0121392645,
-0.0034261837,
0.005094646,
0.017769465,
0.010608124,
-0.00286488,
0.0025164254,
-0.015544849,
0.021957787,
0.025445765,
-0.010319748,
-0.0030399656,
-0.0045899875,
0.010058836,
0.008259918,
-0.033808675,
-0.0035034274,
0.00577439,
-0.01980183,
-0.025692945,
0.012091202,
-0.028233401,
0.027999954,
0.011102484,
-0.04210292,
-0.03213335,
0.005777823,
-0.029304514,
-0.016327584,
0.013162313,
0.014027442,
0.0075321114,
0.0066292193,
-0.0072437353,
0.003100044,
-0.029249584,
0.008479633,
-0.0073261284,
-0.0070446185,
0.009880317,
0.0047341757,
0.031007307,
-0.016519835,
-0.033479102,
-0.014844508,
0.024154939,
0.007017154,
-0.026887646,
0.03809312,
0.010539463,
0.0074840486,
-0.012825875,
0.004013235,
-0.02103773,
0.019389866,
0.031419273,
-0.04957324,
-0.016808212,
0.009516414,
-0.004349674,
0.0044423663,
-0.002959289,
0.0021559554,
-0.019925421,
-0.011287868,
0.0007076374,
-0.034440357,
-0.0027412903,
0.0040372666,
0.0036081353,
0.023344738,
-0.0056782644,
0.024484511,
0.019458527,
0.013251573,
-0.005293763,
0.0018761618,
-0.0014066922,
-0.011500717,
0.0010178993,
0.0019104922,
-0.00073038135,
-0.010436472,
0.021696875,
-0.015462456,
-0.00050079613,
-0.022548271,
-0.022960238,
-0.012873936,
0.01561351,
0.017604679,
-0.022630665,
0.005304062,
-0.004411469,
0.0063477093,
-0.017989181,
0.016368782,
-0.020213798,
-0.019994082,
0.0023636548,
-0.0019808698,
-0.034110785,
0.00088830164,
-0.018442344,
0.001987736,
-0.008342311,
-0.0045762556,
0.19312966,
-0.0075389775,
0.0051186774,
0.03323192,
-0.009090716,
-0.01991169,
0.0039033776,
-0.014350148,
0.010766044,
-0.000752267,
0.015132884,
0.021147586,
-0.0030485482,
0.0010144663,
0.019527188,
-0.00026241376,
-0.023193685,
-0.019595848,
-0.033067137,
-0.01473465,
0.0032613974,
-0.0144874705,
0.009193707,
-0.004147124,
0.018826846,
-0.008987725,
0.00593231,
-0.0056679654,
0.001546589,
0.025528159,
-0.0044560987,
0.0054928795,
-0.023880295,
-0.0036733632,
-0.0034845455,
-0.0017525719,
0.009701799,
-0.00012938307,
0.008246185,
0.0021302074,
-0.018456075,
-0.008582625,
0.010045104,
-0.014034308,
0.0010342062,
-0.014954365,
-0.0009269235,
-0.015778298,
0.008733679,
0.011370261,
-0.040070556,
0.0103952745,
0.03328685,
0.019499723,
0.009797924,
-0.011844022,
0.011383994,
-0.0027189755,
-0.0031309414,
0.023276078,
-0.021930322,
0.0056233355,
-0.017879324,
0.009578209,
-0.013979379,
-0.0074840486,
-0.014597328,
0.01998035,
0.023083827,
-0.019238811,
0.013581146,
-0.0026005353,
-0.011878353,
-0.0047273096,
-0.016904337,
-0.006110829,
0.021710606,
0.028453117,
0.028700296,
0.010683651,
-0.0031498233,
0.022452146,
-0.009406556,
0.02348206,
-0.002334474,
-0.022946505,
0.019650778,
-0.01717898,
-0.020680692,
-0.014144165,
0.025226051,
-0.0010178993,
-0.0059288773,
-0.0072162705,
0.01005197,
0.006000971,
-0.009049519,
-0.003125792,
0.005839618,
-0.020996533,
-0.030348161,
0.0726708,
0.0038484489,
0.025239782,
-0.03128195,
-0.00855516,
-0.022507075,
-0.0026932275,
-0.0132378405,
-0.011150545,
0.0060112705,
-0.021257445,
-0.0058808145,
-0.017659608,
-0.01661596,
0.033369243,
0.0074565844,
-0.031254485,
0.03240799,
0.0017491389,
-0.0043771383,
-0.021120122,
-0.002808235,
0.021078926,
-0.014501203,
-0.011102484,
0.009063251,
0.0034708134,
-0.010463936,
-0.050809138,
0.013416359,
0.018195163,
0.007312396,
0.009749861,
0.02103773,
-0.022136305,
0.006182923,
0.0028957776,
-0.01591562,
-0.0013217242,
-0.016066674,
-0.009873452,
0.020996533,
0.020776818,
-0.02184793,
-0.008967126,
0.0033849871,
0.041718423,
-0.0027945025,
-0.015764564,
0.029936194,
-0.027450666,
0.0127640795,
-0.013279037,
0.015338867,
-0.027684113,
0.004329076,
0.0002328037,
-0.01592935,
-0.007882282,
-0.038120586,
0.011486985,
0.040345203,
0.0074634505,
-0.0076213707,
-0.0032957278,
-0.17500316,
-0.0012204492,
0.0017989181,
-0.03853255,
0.020653227,
0.007628237,
0.017632144,
-0.0013663538,
-0.0018452643,
-0.0039617396,
0.00952328,
-0.00468268,
-0.035044573,
-0.03965859,
-0.00992838,
0.023262346,
-0.03971352,
0.01841488,
0.028205937,
0.0046449164,
0.020653227,
-0.005719461,
0.0021782701,
-0.028123545,
0.016066674,
0.025802802,
0.013917584,
0.0036081353,
-0.01436388,
-0.014130433,
0.0045144605,
0.013505618,
0.04451979,
-0.0018864609,
-0.0089945905,
-0.0008230737,
0.001955122,
0.013951914,
-0.011651771,
0.021696875,
0.03584104,
0.017151518,
0.015668439,
0.017989181,
-0.0020117671,
0.0294693,
0.01214613,
-0.0003724859,
0.008177524,
-0.0118165575,
0.02230109,
0.017810663,
0.026379555,
0.008321713,
-0.006117695,
0.013471288,
0.011411457,
0.025280979,
-0.008513964,
0.004006369,
0.0058979797,
-0.011857755,
0.029084798,
-0.025445765,
-0.0010342062,
-0.013807726,
-0.012523766,
-0.00042784383,
-0.02029619,
0.011473252,
0.008575759,
0.0055752727,
0.00053984707,
0.009688066,
0.0044320673,
0.0013938182,
-0.02272679,
0.006824903,
-0.000006812458,
-0.004136825,
-0.00056130363,
0.013327099,
-0.0117067,
-0.012626757,
0.010278551,
-0.0122903185,
0.0075870403,
-0.004044133,
-0.03152913,
0.018922972,
0.017014194,
-0.009571343,
-0.022108842,
0.0019963186,
0.006351142,
0.0058739483,
-0.016327584,
0.013725333,
0.0008646994,
0.0023361903,
0.022053912,
0.0052559995,
-0.02922212,
0.009104448,
0.05344572,
0.00083466026,
-0.012173595,
-0.0065880227,
0.045398653,
0.012386444,
-0.0010453637,
0.018648326,
0.010663053,
0.023701776,
-0.003978905,
0.022218699,
0.0012324649,
-0.010930831,
-0.014240291,
-0.0155860465,
0.054736547,
0.028425653,
-0.014913169,
0.017069124,
-0.016753282,
-0.0029695882,
-0.1302911,
-0.0031515397,
-0.010127497,
0.017742002,
-0.017316304,
0.00896026,
0.003525742,
0.03207842,
-0.03298474,
0.016835677,
-0.017838126,
-0.009022055,
-0.0062309853,
-0.019128954,
-0.007861684,
0.016876873,
-0.0037420243,
-0.011905817,
-0.005214803,
0.013636074,
0.01248257,
0.00040509988,
0.0018589965,
0.007916613,
0.013958781,
0.010690517,
-0.01973317,
0.036582578,
0.011377127,
0.017700804,
0.0019310905,
-0.024498243,
0.008321713,
-0.013663539,
-0.037736084,
-0.0018006347,
-0.005486014,
-0.028480582,
0.0250338,
-0.021367302,
-0.0021267743,
0.014116701,
0.0452064,
-0.00044457996,
0.011768495,
0.002710393,
0.0020254995,
0.013464421,
0.003446782,
-0.007497781,
-0.028892547,
-0.02116132,
-0.01723391,
-0.0073192623,
0.011445788,
0.0063786064,
-0.0054791477,
-0.0041642897,
-0.02834326,
0.0027481564,
0.00086727424,
0.018620862,
-0.014006844,
0.01767334,
0.007566442,
-0.009681201,
-0.0076900315,
-0.018854309,
0.025802802,
-0.03608822,
0.009578209,
-0.0023464896,
-0.026255965,
-0.0359509,
-0.012791543,
-0.004469831,
-0.036637507,
-0.03732412,
0.030869985,
-0.020996533,
0.005214803,
-0.034083318,
0.014720918,
0.0005922011,
0.0330946,
0.0058224527,
0.018813113,
0.0029077933,
0.017137785,
-0.032545313,
0.009784192,
0.016684622,
0.022795452,
-0.010237355,
-0.01841488,
0.007827354,
-0.012132398,
-0.023303542,
0.0010445054,
0.020790549,
-0.041251525,
0.015077955,
-0.05981746,
0.0056679654,
0.012942598,
-0.00836291,
0.022946505,
0.005849917,
-0.022095108,
0.01592935,
-0.008459034,
0.027986223,
-0.028645368,
0.0124413725,
-0.0060764984,
0.0010445054,
-0.01660223,
-0.017893055,
0.044547256,
-0.01117801,
0.016698355,
0.0343305,
-0.022685593,
0.0014496053,
0.025445765,
0.056906234,
-0.0209828,
-0.010003908,
-0.022438414,
0.006800872,
-0.010930831,
-0.004758207,
0.015956815,
-0.022795452,
-0.011974478,
0.009358494,
0.00009338968,
-0.040867027,
-0.023248613,
0.017549751,
0.015462456,
0.02322115,
-0.013011259,
-0.03216081,
-0.017069124,
-0.0072437353,
-0.01934867,
-0.004617452,
-0.039356485,
0.006361441,
0.0226032,
-0.0056233355,
0.030320697,
-0.007442852,
0.015036758,
-0.02941437,
0.015572314,
0.009935246,
-0.02122998,
-0.01052573,
0.006066199,
-0.021422232,
0.00653996,
0.0020752787,
0.018442344,
0.0012161579,
-0.0017783198,
-0.0030022021,
-0.010340346,
-0.0061245607,
0.008163792,
-0.013560547,
-0.0028065182,
0.029167192,
0.023646846,
0.003851882,
0.014871972,
-0.026736593,
0.0056713982,
0.0048611984,
0.010285418,
-0.0027052432,
0.031062234,
-0.008211855,
0.006969091,
0.011486985,
0.033808675,
0.003417601,
0.011157412,
0.013739065,
-0.013491886,
-0.006399205,
0.0108896345,
0.029853802,
0.015640976,
0.008301115,
0.013258439,
0.014926901,
-0.01364294,
0.005736626,
-0.0009904349,
0.0071201455,
-0.0030125012,
0.007291798,
-0.0067013134,
-0.033973463,
-0.029139727,
0.008012738,
-0.03570372,
-0.007820488,
-0.014405077,
0.013512484,
0.012688552,
-0.0048371674,
-0.0077380943,
-0.003345507,
0.010003908,
0.012654222,
-0.00669788,
-0.025445765,
-0.0029713046,
0.0043702726,
0.023454597,
0.015558582,
-0.001994602,
-0.0042157853,
0.031254485,
0.013601744,
0.021120122,
-0.025226051,
0.020268727,
-0.024278529,
-0.0021920023,
-0.015366331,
-0.0043565403,
-0.011898951,
-0.009543879,
0.003374688,
-0.0059082787,
0.015174081,
-0.007497781,
0.08371149,
0.01061499,
0.0018298156,
0.02441585,
-0.023179952,
0.00278592,
0.008754277,
0.006206954,
-0.014707185,
-0.039740983,
0.017082855,
-0.017893055,
0.018689523,
-0.026709128,
0.0005252566,
-0.0065742903,
-0.019334937,
0.02036485,
-0.0047650733,
-0.0077174962,
0.007834219,
-0.02672286,
-0.0011998509,
0.004414902,
-0.009955845,
-0.015846958,
0.013739065,
0.0070720827,
0.017124053,
-0.016135335,
0.020831747,
0.00076299533,
-0.018057842,
-0.003403869,
-0.00042076316,
-0.00018238077,
-0.00016210432,
-0.019032829,
-0.0025868032,
0.016396247,
-0.00234134,
-0.029112263,
-0.0031824373,
-0.013436957,
-0.013965647,
-0.008081399,
-0.014707185,
-0.017055392,
-0.020721888
] |
Pluripotent stem cells (PSCs) occupy a spectrum of reversible molecular states ranging from a naive ground-state in 2i, to metastable embryonic stem cells (ESCs) in serum, to lineage-primed epiblast stem cells (EpiSCs). To investigate the role of DNA methylation (5mC) across distinct pluripotent states, we mapped genome-wide 5mC and 5-hydroxymethycytosine (5hmC) in multiple PSCs. Ground-state ESCs exhibit an altered distribution of 5mC and 5hmC
|
[
-0.019616848,
-0.0017574537,
-0.0023571535,
-0.037234697,
-0.034675978,
0.02156254,
-0.011667494,
0.0119207,
-0.024014646,
-0.010807924,
0.0031167732,
0.008389134,
-0.012806923,
0.0030984492,
-0.01729801,
0.012267194,
0.023175066,
-0.018190894,
-0.011907374,
0.03379642,
-0.026413446,
-0.0052873534,
0.0020972835,
-0.015232376,
0.00043436594,
0.022175567,
-0.0022005653,
-0.026986493,
-0.0005430615,
-0.021882381,
0.01347992,
0.0007995998,
-0.009588534,
-0.007722801,
-0.023987994,
-0.003448274,
0.0030151575,
-0.02388138,
0.011434277,
-0.014539389,
0.00564051,
0.013619849,
-0.016591696,
0.0010852901,
0.002502081,
-0.009848404,
0.00015169491,
0.0021655827,
-0.007169745,
0.025667153,
0.019323662,
0.002660335,
-0.0042911856,
0.003858069,
-0.016271856,
-0.007809425,
0.0043278337,
0.012906874,
0.00035919523,
-0.0027386292,
0.0036415106,
-0.0029035467,
-0.028812246,
0.01228052,
0.007196398,
0.0103614805,
-0.008855567,
0.0043078437,
0.007303011,
0.0051574185,
0.020229874,
0.009721801,
-0.010588034,
-0.02080292,
0.011967343,
0.006190235,
-0.022188894,
-0.005097449,
0.0044910857,
0.014725963,
0.021829074,
-0.018777268,
-0.01389971,
0.011734127,
-0.002592036,
0.013013487,
-0.0009478589,
0.0019690145,
0.019003822,
-0.004987504,
0.046296827,
0.03574211,
0.019110436,
-0.001126103,
-0.018244201,
0.014659329,
0.0067732767,
0.023015147,
-0.0012635342,
-0.01168082,
-0.02200232,
0.02416124,
-0.010481421,
-0.010787934,
-0.037474576,
-0.0068299146,
0.004907544,
0.0046510054,
0.010474757,
-0.007702811,
-0.012333827,
0.012573707,
-0.0039813407,
-0.051014464,
0.034889203,
0.00016491745,
0.00041541707,
0.0140196495,
-0.018457428,
-0.009302011,
0.018990494,
0.025493907,
0.018777268,
-0.038647324,
0.008629015,
0.013806423,
-0.02368148,
-0.014552716,
-0.01110111,
0.0065633818,
0.019989995,
-0.006956518,
-0.020389795,
0.011467594,
-0.021429274,
-0.0084690945,
-0.0072363783,
-0.0082158875,
-0.017284682,
-0.026533386,
-0.00038293333,
0.012313836,
-0.001944027,
0.0018690645,
0.01278027,
0.00012150169,
0.0010611356,
-0.00048017633,
0.012473756,
0.007116438,
0.012786933,
-0.009268695,
0.03627518,
0.0077627813,
-0.020509735,
0.0085423915,
0.023454927,
0.009355318,
-0.030118259,
-0.009228714,
-0.01689821,
-0.0029351974,
0.016405122,
0.0059770085,
0.010274857,
0.030064952,
0.013659829,
0.0013076788,
-0.007962681,
-0.00667999,
-0.015765442,
0.02216224,
-0.049468573,
0.0036181891,
-0.011227714,
0.01064134,
-0.009568544,
0.017218048,
-0.02632016,
-0.02128268,
-0.0036814907,
0.02000332,
0.012487084,
0.015152416,
-0.02340162,
0.00522072,
0.022548715,
-0.009388634,
-0.002222221,
-0.017964343,
-0.00622022,
0.0012535392,
0.0061036116,
0.015472256,
-0.6371211,
-0.047149733,
-0.0077427914,
-0.018790595,
0.024387794,
0.03294351,
0.0103614805,
-0.00006267696,
-0.016351815,
0.020509735,
-0.0076828212,
0.010208224,
-0.0064834217,
-0.010488084,
-0.020936187,
-0.027719459,
-0.008569044,
-0.023015147,
0.013093446,
-0.019989995,
-0.036088604,
0.0006375975,
-0.012107274,
0.014312836,
0.0016966508,
-0.0010686318,
0.024454426,
0.012593697,
-0.0111810705,
0.030651325,
-0.027186392,
0.01916374,
-0.01569881,
-0.005310675,
0.05096116,
0.02416124,
0.00057387946,
0.022575367,
-0.00060386444,
0.037954338,
-0.0019307003,
-0.005750455,
0.018417448,
0.017911036,
-0.017444601,
0.038140908,
0.0049808403,
-0.00027923525,
0.009901711,
0.011234377,
0.013992996,
0.00008204227,
-0.009008824,
0.0011102776,
0.022388794,
0.0071497546,
0.020816248,
-0.00058470736,
0.030091606,
0.007536228,
0.007802761,
0.022735287,
-0.023015147,
-0.017284682,
-0.0030618007,
0.022575367,
-0.020869555,
-0.00666,
0.009461931,
-0.031370964,
0.0072497046,
0.024174567,
-0.00510078,
-0.007116438,
0.011974007,
0.014512736,
0.009355318,
-0.007962681,
-0.0005343159,
0.018324161,
0.009728464,
-0.0069431914,
-0.018150914,
0.00061427586,
0.029318659,
0.0027419608,
-0.0035648823,
0.0077694445,
-0.017231375,
0.015338989,
0.01188072,
0.020643001,
0.009875057,
-0.042005643,
-0.016618349,
-0.004890885,
0.0056971484,
0.005530565,
0.010568044,
-0.01637847,
-0.030278178,
0.005733797,
0.01296018,
0.016125262,
0.021216048,
-0.007076458,
-0.03262367,
-0.009155418,
0.038940508,
-0.018857228,
0.017724462,
0.00060011627,
-0.014632676,
0.00130518,
-0.007169745,
-0.020989494,
0.0011685818,
0.010561381,
-0.029931685,
-0.02156254,
0.010274857,
0.0064034616,
-0.0144194495,
0.009135428,
0.0050474736,
0.017271355,
0.0044144574,
0.00039792582,
-0.0064101247,
-0.004787604,
0.009102111,
-0.0115209,
0.016125262,
-0.03470263,
0.026573366,
-0.013459929,
0.01080126,
-0.006869895,
0.014166242,
-0.011574207,
-0.033689804,
-0.0076628313,
0.01088122,
-0.006766613,
-0.009868394,
-0.027506232,
-0.027346313,
-0.017951015,
0.021136088,
0.003508244,
0.0046809902,
0.009928364,
0.0054372787,
0.023148414,
0.007496248,
-0.003578209,
-0.014166242,
-0.00602032,
-0.0011177738,
-0.020456428,
-0.016325163,
0.036248524,
0.0010353151,
-0.004887554,
0.00095951976,
-0.015072456,
-0.022175567,
0.0056271837,
-0.019177068,
-0.019483581,
-0.018963842,
-0.0052173887,
-0.008249205,
0.0038247523,
-0.025493907,
0.011367643,
-0.0014567708,
0.003898049,
-0.028199218,
-0.009715137,
-0.009935027,
-0.011174407,
-0.0030351474,
0.00081584166,
0.038567364,
0.0072230515,
0.024427773,
0.0051607504,
0.0023371635,
0.020243201,
0.0043311655,
0.028225873,
-0.0120539665,
0.020203222,
0.030144911,
-0.030917859,
0.0020306504,
-0.004194567,
-0.0116541665,
0.026573366,
-0.0047309655,
0.003508244,
0.005550555,
-0.030118259,
0.040912855,
-0.04517739,
-0.019590195,
-0.009155418,
0.008822251,
0.01893719,
0.0008545723,
0.0055605504,
-0.015338989,
-0.023628173,
0.0036948174,
-0.007982671,
-0.022508735,
-0.023388295,
0.0012410455,
0.01306013,
0.01332,
-0.0011819084,
0.01729801,
-0.00025570535,
0.0066266833,
-0.0016674987,
0.01046143,
0.009555218,
-0.006789935,
-0.003738129,
0.008375808,
0.0086689945,
-0.0075695445,
-0.015325663,
0.024627673,
0.022068953,
0.028892206,
-0.011747453,
0.04205895,
0.0019473586,
0.0034849225,
0.018977169,
0.025094107,
-0.0056938166,
-0.0034216207,
-0.027426273,
0.04005995,
0.002013992,
-0.0069098747,
0.00572047,
-0.038114257,
-0.008395798,
-0.021056127,
0.005510575,
0.005244042,
-0.016271856,
-0.011754117,
0.019550215,
0.02456104,
0.00642012,
-0.007696148,
-0.01397967,
0.0006238544,
-0.021575868,
0.014912536,
-0.0048309155,
0.010941191,
-0.0027669484,
-0.03379642,
-0.01561885,
-0.024107933,
0.014659329,
0.0035548874,
-0.030411445,
-0.0039013806,
-0.01310011,
0.023508234,
-0.003918039,
0.018150914,
-0.0007954352,
-0.0060136565,
-0.016151916,
0.014939189,
0.028172566,
-0.011727463,
0.0009786768,
-0.030544711,
-0.021122761,
-0.0067266333,
0.010867894,
-0.0045510554,
0.013713136,
-0.0073629813,
-0.0072230515,
-0.025507232,
-0.026919859,
0.004544392,
0.0015475587,
0.024107933,
-0.009941691,
-0.0036048624,
-0.005204062,
-0.009708474,
-0.003944692,
0.026533386,
0.01609861,
-0.0067199697,
-0.006689985,
-0.001924037,
-0.024174567,
-0.014406123,
-0.018230876,
0.0025353977,
0.008255868,
-0.0082691945,
-0.0015991996,
0.031584192,
-0.007882721,
0.031344313,
0.002272196,
-0.02412126,
-0.024747614,
-0.020109935,
-0.014899209,
0.023588194,
0.024334487,
-0.009368644,
-0.0046410104,
0.00044436092,
-0.00007876266,
0.004567714,
-0.017457929,
0.013453267,
-0.009408624,
-0.0056638317,
0.021176068,
0.0027369633,
-0.02136264,
0.010548054,
0.029585192,
0.0070364783,
-0.01689821,
-0.035129085,
-0.003938029,
0.0015525563,
-0.010121601,
0.018817248,
0.053546533,
0.018150914,
0.005633847,
0.019616848,
0.012093946,
-0.0129202,
-0.012307174,
-0.016338488,
0.017977668,
0.019190395,
0.0070231515,
0.008695648,
-0.02332166,
0.00980176,
0.012107274,
0.0068632313,
0.0032083942,
0.019656828,
0.0022472085,
-0.00014138757,
0.0016408454,
0.011574207,
0.0018923861,
-0.004397799,
0.0065200697,
0.00540063,
-0.01166083,
0.02196234,
-0.028172566,
-0.019257028,
-0.00616025,
0.0035682141,
0.007316338,
0.003758119,
-0.013846403,
-0.013619849,
-0.014805922,
-0.0060269833,
-0.016071955,
0.0040812907,
-0.0038647323,
0.00035940344,
-0.017164743,
0.008482421,
-0.011967343,
-0.021549214,
-0.010521401,
0.013266693,
-0.031477578,
-0.04986837,
-0.0030434767,
0.03214391,
0.018604022,
0.013646503,
-0.010288184,
-0.004467764,
0.02779942,
-0.004354487,
-0.012953516,
0.0043278337,
-0.021575868,
-0.007216388,
0.0014117934,
0.0050807903,
-0.0047109756,
-0.0252407,
0.0018857229,
0.01262035,
-0.013286683,
-0.01609861,
0.010687984,
-0.03752788,
0.035528883,
0.009468595,
0.008329164,
-0.00011265195,
0.007536228,
-0.00032921022,
-0.041206043,
-0.027985992,
-0.015632175,
0.000014029436,
-0.021136088,
-0.0108345775,
0.021109434,
-0.016138589,
-0.017244702,
0.008102611,
-0.028812246,
0.013293346,
0.008549054,
0.036035296,
0.01876394,
-0.009808424,
0.019083781,
-0.009715137,
-0.014899209,
0.011214387,
-0.021829074,
0.032357138,
-0.0003283773,
-0.02432116,
-0.01102115,
-0.0016583366,
-0.011614187,
-0.023388295,
0.002232216,
-0.006453437,
0.036461752,
-0.022375468,
-0.00015471423,
0.0010211555,
0.00275029,
0.023068454,
0.016978169,
-0.004644342,
0.0035715457,
-0.0021805752,
0.008135928,
-0.014606022,
-0.013066793,
0.013992996,
-0.03190403,
-0.0014334492,
0.026813246,
-0.0014659329,
0.00532067,
0.0032866884,
0.0073629813,
-0.022055628,
-0.0067532863,
-0.0042345473,
-0.029398618,
0.01062135,
-0.02955854,
0.057091426,
0.03598199,
0.028545713,
-0.012373807,
0.009795098,
0.015192396,
0.014939189,
-0.023868054,
-0.0011394297,
0.02196234,
-0.014059629,
0.026933186,
-0.0034682641,
0.00018511568,
0.016951516,
-0.0230418,
0.017151415,
0.04765615,
-0.020896208,
-0.0114542665,
0.022415448,
-0.035235696,
-0.04029983,
-0.0019023812,
-0.01377977,
0.014646003,
-0.030811245,
-0.016311835,
0.0010544722,
0.00072921836,
0.00031088607,
-0.0017924362,
0.043071777,
-0.009635177,
0.03062467,
-0.014299509,
0.014526063,
-0.006756618,
-0.0026053626,
-0.0026303502,
-0.008589034,
0.01373979,
-0.0044011306,
0.020016648,
0.0033333316,
-0.01813759,
0.009528564,
0.0031084442,
-0.03446275,
-0.018484082,
-0.001216058,
-0.03758119,
-0.0045010806,
-0.007842741,
-0.012293846,
-0.034329485,
0.0013593197,
0.00092037267,
-0.015112436,
0.020309834,
-0.028492406,
-0.0144194495,
0.02368148,
-0.010248204,
0.031930685,
-0.020389795,
0.015991995,
0.021549214,
-0.0035515558,
-0.030864552,
-0.018364143,
-0.017098108,
0.0018923861,
0.05399964,
0.018004322,
0.0009478589,
-0.01316008,
-0.004814257,
-0.0031067783,
-0.009115438,
-0.026586693,
-0.01274029,
-0.009568544,
-0.0147659425,
-0.006686653,
0.0066166883,
-0.029078778,
0.01200066,
-0.00028506565,
0.007716138,
-0.011574207,
-0.010974507,
-0.02496084,
0.029451925,
0.0038447422,
0.00654006,
0.018297508,
0.010568044,
-0.012793597,
-0.031584192,
-0.008722301,
0.024347814,
0.0029451926,
0.034729283,
-0.009661831,
0.008649005,
0.00960186,
-0.011574207,
-0.0067532863,
-0.00038834728,
0.009535227,
0.03446275,
-0.008942191,
-0.00265034,
0.014406123,
0.019936688,
0.017471256,
0.004184572,
-0.014486083,
-0.02667998,
-0.039766762,
-0.009635177,
0.014872556,
0.0053473236,
0.012213887,
-0.024587693,
-0.02995834,
-0.00618024,
-0.034009643,
-0.020829575,
0.01162085,
-0.03294351,
-0.0023671486,
0.0056838216,
0.020962842,
0.028092606,
0.0035448924,
0.012966843,
0.003788104,
0.026706632,
-0.0042278836,
0.017951015,
0.02048308,
0.007556218,
-0.019830074,
0.019496908,
-0.011354317,
-0.040672977,
-0.024947513,
-0.024694307,
-0.020949515,
-0.0068365782,
-0.0020523062,
0.026919859,
-0.014845903,
-0.010008324,
-0.009515237,
0.017084783,
0.027906032,
0.004164582,
-0.017804421,
0.0008383304,
-0.042005643,
-0.007882721,
0.010941191,
-0.0016458429,
-0.016698308,
-0.011867394,
-0.02480092,
0.003488254,
-0.020016648,
0.016511736,
0.008249205,
-0.00048683965,
-0.0149658425,
0.010687984,
-0.004544392,
-0.0073429914,
-0.021229375,
0.00088372437,
0.0059670135,
0.008042641,
-0.041445922,
0.0005189069,
0.027319659,
-0.002761951,
-0.018377468,
0.008855567,
-0.011967343,
-0.035875376,
-0.03934031,
0.02168248,
-0.02528068,
0.03278359,
0.029931685,
-0.017964343,
-0.033982992,
0.005144092,
-0.055812065,
-0.033529885,
0.017617848,
0.015232376,
0.019550215,
0.015312335,
0.0020672986,
-0.019710135,
0.010474757,
0.008162581,
0.006446773,
-0.003898049,
0.019536888,
-0.014286183,
0.011934027,
0.014366142,
-0.022708634,
-0.0069098747,
0.022135587,
0.0035948674,
-0.0011993997,
0.008842241,
-0.003011826,
0.048668973,
0.0021372635,
0.022775266,
0.013686483,
0.0053606504,
0.015885383,
-0.022228874,
0.0037947672,
-0.0030834568,
-0.014805922,
-0.015458929,
0.0062268833,
0.0018673986,
-0.0069631813,
0.005810425,
-0.0032467083,
-0.021922361,
0.012933526,
-0.011867394,
0.024974167,
0.009595198,
0.009428614,
0.005423952,
0.02779942,
0.0001709561,
-0.014725963,
-0.012173907,
-0.005823752,
-0.008102611,
0.0053506554,
0.0012693646,
-0.0097617805,
0.00084541016,
-0.015672157,
-0.021882381,
-0.00012743621,
0.0073230015,
-0.010874557,
-0.01236048,
0.026973166,
-0.019123761,
-0.030917859,
-0.019243702,
0.002240545,
-0.017004821,
-0.013806423,
0.009741791,
-0.017404621,
0.000837081,
0.010328164,
-0.0020356479,
-0.002452106,
0.0024471085,
0.01377977,
0.008555718,
0.0014567708,
0.017644502,
0.19744784,
-0.0041079437,
0.0017607854,
0.030171566,
0.009255367,
-0.021975668,
0.01064134,
-0.0032933515,
0.011314337,
-0.001964017,
0.018550714,
0.0053972984,
-0.00007647214,
0.001485923,
0.025254026,
-0.0058604,
-0.019843401,
-0.013026813,
-0.009042141,
-0.02652006,
0.0080692945,
-0.0127203,
0.015725462,
-0.0066366782,
-0.0027919358,
-0.0010453102,
-0.026413446,
0.009228714,
0.020429775,
0.011574207,
-0.020589694,
0.02915874,
-0.0027469585,
-0.0007529565,
0.016111936,
0.0021122762,
0.013526563,
-0.026786592,
-0.0073096748,
-0.017337989,
-0.005623852,
0.018923862,
0.003528234,
0.01569881,
-0.013659829,
0.0053773085,
-0.0072097247,
0.0017557879,
0.011154417,
-0.0045343973,
-0.034915857,
0.023388295,
0.0065267333,
0.024641,
0.0015583866,
-0.009528564,
0.013166743,
0.01893719,
-0.015605522,
0.02216224,
-0.011214387,
0.008522401,
-0.015645502,
0.0072497046,
-0.016658328,
0.022468753,
-0.0132000595,
-0.01373979,
0.015738789,
-0.028305832,
0.013020149,
0.003040145,
-0.0050707953,
0.012607023,
-0.0082691945,
-0.034835897,
0.06700646,
0.020549715,
0.017444601,
0.020896208,
0.0095618805,
-0.0055638817,
-0.02328168,
-0.008235877,
0.01262035,
-0.050401438,
0.042218868,
0.020656329,
-0.037954338,
-0.0125204,
0.008342491,
-0.0016275187,
-0.0020089943,
0.007502911,
0.001794102,
-0.012247203,
-0.009908374,
0.0039147073,
-0.008808924,
-0.008649005,
-0.0238414,
0.062955156,
0.002033982,
0.010028314,
0.0054705953,
0.027506232,
-0.003728134,
-0.0062168883,
-0.019830074,
0.0006017821,
0.014832576,
-0.018217549,
0.0084690945,
-0.01238047,
-0.005930365,
0.030571366,
-0.012746953,
-0.018457428,
0.05312008,
0.007456268,
-0.007476258,
-0.023188394,
0.0021972335,
0.02787938,
-0.008702311,
0.00008287519,
-0.028865552,
0.010827914,
-0.009868394,
-0.017604522,
-0.013033477,
-0.0012627013,
0.02675994,
0.019856729,
-0.008562381,
-0.0031950674,
0.011407624,
0.011587533,
-0.020936187,
0.00022551212,
-0.010174907,
-0.013040139,
-0.0004233298,
0.01098117,
-0.009621851,
-0.025653826,
0.023574866,
0.028465752,
-0.013386633,
-0.025267353,
-0.019856729,
-0.0039247023,
-0.00065800396,
0.0056271837,
0.018297508,
-0.015792096,
-0.0066333464,
-0.031291004,
-0.021029474,
0.027932685,
-0.027772766,
0.033396617,
-0.009655167,
0.00064717606,
-0.004697649,
-0.0008753952,
-0.16791596,
-0.011227714,
0.038940508,
-0.034649324,
0.029798418,
0.03798099,
0.013293346,
-0.013353316,
-0.01248042,
0.007489585,
0.03206395,
0.0032133916,
-0.045870375,
-0.009655167,
0.012846903,
0.016471755,
0.0042278836,
0.044191215,
0.0023071785,
0.0040912856,
0.017751114,
-0.007576208,
0.0038514056,
-0.0072230515,
0.024387794,
-0.0073096748,
0.0016333491,
0.0031234366,
-0.026480079,
-0.016764943,
-0.015792096,
0.0010677989,
0.024907533,
0.014352816,
0.01080126,
0.0024271186,
-0.008135928,
0.0008291683,
0.009115438,
0.017644502,
0.017178068,
-0.0014451101,
-0.002920205,
-0.0018657328,
0.0010553051,
0.030571366,
-0.018230876,
-0.014672656,
0.020349814,
-0.0060136565,
0.019830074,
0.020349814,
-0.00039917522,
0.0042278836,
0.019683482,
0.006546723,
0.019843401,
0.005324002,
-0.00022759441,
-0.01637847,
-0.008622351,
-0.015125763,
0.023694808,
-0.016151916,
0.005314007,
-0.019430274,
0.018190894,
0.022055628,
-0.038647324,
0.003858069,
-0.0010419785,
-0.019803422,
-0.004467764,
-0.011514237,
0.03219722,
-0.0013384967,
0.008569044,
0.008662331,
-0.005184072,
0.004454437,
-0.023868054,
0.020909535,
-0.034809243,
-0.029078778,
-0.007802761,
-0.0011977338,
0.0008312506,
0.010741291,
-0.008828915,
0.0019506903,
0.006769945,
-0.020696308,
0.010194898,
0.0030034967,
0.02779942,
0.010394797,
-0.010894547,
-0.018950514,
-0.018777268,
-0.002032316,
0.021469254,
-0.004064632,
-0.0240413,
0.0017108103,
0.022535387,
-0.007402961,
-0.009728464,
0.006869895,
0.045657147,
-0.018070955,
0.007862731,
-0.011314337,
0.005390635,
0.031717457,
0.0045377286,
0.035555538,
0.000016033642,
0.0014492746,
0.000026041653,
-0.016085282,
0.07393633,
-0.009068795,
0.005643842,
0.03997999,
0.015192396,
-0.00020635505,
-0.14083618,
0.0023854726,
-0.0034216207,
0.0228419,
-0.0060836216,
0.028465752,
-0.013146753,
0.01769781,
-0.019923361,
0.03790103,
-0.0030767934,
-0.027133087,
0.015818749,
-0.0039080437,
0.0032067283,
-0.008389134,
-0.0019356979,
-0.0069631813,
-0.030784592,
0.044697627,
0.002980175,
-0.0021622512,
-0.014099609,
-0.030331485,
0.039740108,
0.022028973,
-0.038913857,
0.016871555,
0.033210043,
0.028252525,
-0.007396298,
-0.024627673,
0.00034357802,
0.013966342,
-0.011227714,
0.008442441,
-0.0004656003,
-0.035075776,
0.03694151,
-0.014632676,
-0.006350155,
0.000009259688,
0.0039247023,
-0.0066433414,
0.01314009,
-0.0067299646,
-0.008369144,
-0.009828414,
0.007576208,
-0.02875894,
-0.055438917,
-0.023908034,
-0.0077494546,
-0.0010061631,
-0.0019523562,
-0.024894206,
0.018150914,
0.02300182,
-0.009155418,
0.00048600676,
-0.0056371787,
-0.013766443,
-0.027639499,
-0.00012889382,
0.010694647,
-0.023414947,
-0.037048124,
-0.021695808,
0.012607023,
-0.015472256,
-0.018030975,
0.021629173,
-0.01641845,
0.010954517,
-0.028039299,
-0.005613857,
0.002172246,
-0.005064132,
0.014805922,
-0.015792096,
0.0026769934,
-0.02256204,
0.0024471085,
-0.005104112,
0.02755954,
0.00013857648,
0.01182075,
0.010934527,
0.00093952974,
0.000077357116,
-0.0023987994,
0.042911854,
-0.014392796,
-0.052933507,
0.0052673635,
0.010894547,
0.006310175,
-0.0032033967,
0.030064952,
0.008075958,
-0.0033466583,
-0.017604522,
-0.05991668,
0.025507232,
-0.008429115,
-0.0043111756,
-0.0013176738,
-0.032970164,
-0.0011685818,
-0.016085282,
0.008429115,
0.0029968333,
-0.021269355,
-0.0015667158,
-0.028465752,
-0.00622022,
-0.029905032,
0.0035948674,
0.022148915,
0.013833077,
-0.0007075625,
0.021549214,
-0.022895208,
-0.0036615008,
-0.003951356,
-0.0040712957,
0.003011826,
-0.00061052776,
-0.010081621,
0.013953016,
-0.019496908,
-0.020149915,
-0.0031167732,
-0.036035296,
-0.021176068,
0.010208224,
-0.020349814,
-0.0029535217,
0.011354317,
0.02500082,
0.02660002,
0.028492406,
-0.0025770434,
-0.02747958,
0.018710636,
0.012946853,
0.004934197,
0.0074829212,
-0.04173911,
0.01236048,
0.0032583692,
-0.006666663,
0.055172384,
0.015205722,
0.02572046,
-0.01956354,
-0.0070431414,
-0.02779942,
-0.014152916,
0.019230375,
0.00007126641,
-0.0029868383,
0.007802761,
0.031530883,
0.022855228,
-0.009062131,
-0.0033000149,
-0.0049808403,
-0.021176068,
-0.0047109756,
-0.008389134,
-0.02795934,
-0.023135087,
-0.0025787093,
0.021749115,
0.013953016,
0.0019673486,
-0.022428773,
0.008895547,
0.023295008,
-0.0129202,
0.033876378,
0.006470095,
0.0033416608,
-0.0047109756,
-0.006236878,
0.04341827,
-0.011760781,
-0.010394797,
0.017364642,
-0.0064034616,
0.0031384293,
0.00596035,
0.012746953,
0.012347153,
0.012573707,
0.012567043,
0.013053467,
-0.0072030616,
0.013206723,
0.015405622,
0.03214391,
-0.01397967,
0.009175408,
0.020429775,
-0.026386794,
-0.0010802926,
0.023095107,
-0.020123262,
-0.022015648,
-0.0044511054,
0.012786933,
0.010334827,
0.009508574,
-0.008728964,
0.008848905,
-0.01369981,
0.0010494747,
0.0036148573,
-0.018444102,
-0.014392796,
0.040166564,
0.0042145574,
0.0117208,
0.010901211,
-0.01294019,
0.020976167,
-0.0029951676,
0.027372966,
-0.004504412,
0.035129085,
0.0054839216,
0.022095608,
0.013506573,
-0.020123262,
-0.015005822,
-0.0128002595,
-0.0064967484,
0.010941191,
0.014446103,
-0.007489585,
0.072710276,
0.014166242,
-0.028998818,
0.0049708453,
-0.019496908,
0.026386794,
0.020616347,
0.018044302,
-0.014059629,
-0.01220056,
0.031637497,
-0.031850725,
0.028732285,
-0.04189903,
-0.004077959,
0.020962842,
-0.020576367,
0.03246375,
-0.022495408,
-0.013913036,
0.011874056,
-0.008495748,
0.009142091,
0.0028352477,
-0.02040312,
-0.008595698,
0.021549214,
-0.017178068,
0.025347313,
-0.00301016,
0.014152916,
-0.004061301,
-0.0464834,
0.0120539665,
0.0091620805,
0.0072430414,
-0.0050674635,
-0.03918039,
0.02719972,
0.020269854,
-0.024374466,
-0.008115938,
-0.011027814,
-0.018457428,
0.0086689945,
-0.0063934666,
-0.0029435267,
-0.012846903,
-0.008728964
] |
Febrile (fever-induced) seizures affect 3–5% of infants and young children. Despite the high incidence of febrile seizures, their contribution to the development of epilepsy later in life has remained controversial. Combining a new rat model of complex febrile seizures and patch clamp techniques, we determined that hyperthermia-induced seizures in the immature rat cause a selective presynaptic increase in inhibitory synaptic transmission in the hippocampus that lasts into adulthood. The long-lasting nature of these potent alterations in synaptic communication after febrile seizures does not support the prevalent view of the 'benign' nature of early-life fe
|
[
-0.006165256,
0.023719762,
0.013681892,
-0.055937763,
-0.029932082,
0.0000834108,
0.0013631468,
-0.013345728,
-0.0071603023,
-0.009990807,
-0.0055769677,
0.018636957,
-0.0010832899,
0.023585297,
-0.009345371,
0.000560134,
0.04340555,
0.006740097,
0.010434544,
-0.0041146525,
-0.0074695735,
-0.00048785863,
0.011402697,
-0.008989037,
-0.024486218,
0.012485147,
-0.0020085825,
-0.04184575,
-0.02753859,
-0.0016261955,
0.004622261,
0.0040575047,
0.0008513364,
-0.00803433,
-0.020169865,
-0.01893278,
0.017184725,
-0.011617843,
-0.0027615908,
-0.008289815,
0.017574677,
0.005627393,
-0.010205952,
0.022375105,
-0.003136414,
-0.005059275,
-0.008061223,
-0.018892441,
0.0030792663,
0.014293712,
0.041388564,
0.023397045,
0.002929673,
0.019000014,
-0.009029376,
-0.02271127,
0.0119472835,
0.011335465,
0.007570423,
-0.026704902,
0.015813176,
0.012478423,
-0.026449418,
0.0062055956,
-0.004800428,
0.013722233,
0.009600856,
0.022751609,
-0.0054492257,
0.006000535,
0.03170703,
0.032702077,
-0.01508706,
-0.032460038,
0.017843608,
-0.01146993,
0.0030943935,
-0.009231076,
-0.010616072,
0.0028792485,
0.0071871956,
-0.027215872,
-0.025400585,
0.022213746,
0.003600321,
-0.01776293,
0.004561751,
0.010831218,
0.003573428,
0.013540704,
-0.011711969,
0.020963214,
-0.0024640854,
0.022966754,
0.010306802,
0.014266819,
-0.019914381,
0.021017,
-0.008047776,
0.00063577096,
0.003933124,
0.014092013,
-0.0042961813,
-0.02322224,
-0.018690743,
0.005153401,
-0.0014102098,
0.0005092891,
0.014092013,
-0.025373692,
0.0013530619,
0.037273914,
-0.015624923,
-0.036198188,
0.0046760472,
0.0047869817,
0.02388112,
-0.009479837,
-0.016552737,
-0.032782756,
0.009802555,
-0.0072745983,
-0.013890314,
0.00041999543,
0.022684377,
0.007711612,
-0.02958247,
-0.004215502,
-0.00043113087,
-0.028963927,
-0.001729566,
-0.016673757,
0.008115009,
0.000560134,
-0.017319191,
0.026409078,
-0.011900221,
-0.023423938,
-0.010138719,
-0.021770008,
0.00031515415,
0.020855641,
-0.03237936,
0.0037784881,
0.006656056,
0.036251973,
0.018247005,
0.036117505,
0.0058727926,
0.0036238525,
0.0062055956,
-0.013500364,
0.014791235,
-0.0058358144,
-0.0029733744,
0.043271087,
0.015221526,
0.029205967,
0.0010597584,
-0.018865548,
0.004070951,
-0.036628477,
-0.009197459,
0.031680137,
0.0075771464,
0.010683306,
0.007220812,
-0.01578628,
0.035176247,
-0.0044474555,
-0.012478423,
0.027229318,
-0.008215859,
0.021433845,
-0.0068308613,
-0.0005857665,
-0.013453301,
0.020532923,
-0.019228606,
-0.03657469,
-0.027995775,
0.010044593,
0.017372977,
0.001956477,
-0.0037347868,
-0.0025027443,
0.02242889,
-0.011012747,
-0.0025750196,
-0.0064409105,
0.009130226,
0.012599443,
-0.0035935978,
-0.016848562,
-0.62564236,
-0.0027178894,
0.017198173,
-0.023961801,
-0.007778845,
0.022065833,
0.008773891,
0.0095739635,
-0.010864834,
0.030281693,
-0.011664906,
0.031922173,
0.02310122,
-0.0060912995,
-0.023908015,
-0.020358117,
-0.006834223,
-0.016404824,
0.010293355,
0.007496467,
0.023908015,
0.024297966,
-0.019201713,
0.028264705,
0.018946227,
0.012733908,
0.00034982112,
-0.026059467,
-0.002240536,
0.0044541787,
-0.013137306,
0.026180485,
-0.004575198,
0.015826622,
0.057282418,
-0.01011855,
-0.0052340804,
0.045153607,
0.0049483404,
0.03902197,
-0.013473471,
-0.014629876,
0.034934208,
0.0039264006,
-0.022872629,
0.00265738,
-0.0132448785,
0.029367324,
-0.00097571727,
-0.036682263,
0.0180722,
-0.015651817,
-0.024755148,
0.02148763,
0.0071603023,
0.003657469,
-0.00016072862,
-0.02608636,
-0.01563837,
0.0017497359,
-0.0052408036,
0.012088473,
-0.0035230033,
-0.003553258,
-0.038860608,
0.016404824,
0.00057988364,
-0.018287346,
-0.0058190064,
-0.018892441,
0.003647384,
0.0159073,
-0.012491871,
-0.011194276,
0.010219399,
0.015705602,
0.0043701376,
-0.0061450857,
-0.004679409,
0.0012068303,
0.005408886,
0.0024338304,
-0.056152906,
0.0010345461,
-0.0020959852,
-0.01194056,
-0.010071486,
0.0144147305,
-0.016915794,
-0.015961086,
0.00789314,
0.0147643415,
0.0008425121,
-0.048407678,
-0.020519476,
0.012350681,
0.0131507525,
0.010246292,
0.0037852116,
-0.0022354934,
-0.015503904,
-0.0134667475,
-0.010300078,
0.0038356362,
0.015167739,
0.01968579,
-0.02451311,
0.0049281707,
0.03697809,
-0.00547948,
-0.005983727,
0.016082106,
0.0022237278,
-0.0046726856,
0.013486917,
-0.025508158,
0.005321483,
-0.002334662,
-0.012747356,
-0.025817428,
-0.0029481621,
0.0050693597,
0.0019463921,
0.001058918,
-0.0027279744,
-0.0033885376,
-0.0068274997,
0.006851031,
-0.00091604807,
-0.03861857,
0.00251451,
-0.016767882,
0.02365253,
-0.0074897436,
-0.0021850688,
0.0028624402,
0.01838147,
-0.00058072404,
0.0027246128,
-0.011900221,
-0.00100177,
0.020425351,
0.008531854,
0.01725196,
0.0026422525,
-0.0034860251,
-0.01618968,
0.0012253193,
-0.0044575403,
-0.009150396,
0.018435258,
0.013944101,
-0.0028994184,
-0.007496467,
0.009782385,
-0.010925344,
0.002855717,
-0.023087773,
-0.012881821,
-0.012585997,
0.015060167,
0.02019676,
-0.01653929,
0.02600568,
-0.040554877,
-0.036924303,
0.0057248804,
0.0014463475,
-0.013473471,
-0.02271127,
-0.009432774,
-0.02596534,
0.0033784525,
0.0022203662,
-0.007341831,
0.023760103,
-0.0017648633,
-0.0036641923,
-0.014912254,
0.012249832,
0.0010984173,
-0.014347498,
-0.027592376,
-0.0009320159,
0.03999012,
-0.0048743845,
0.033213045,
-0.0033498786,
-0.0005160124,
0.040635556,
-0.0071871956,
0.029824508,
-0.009963914,
0.00039751444,
0.0059333025,
-0.02698728,
0.02510476,
0.0005302994,
0.004481072,
0.031518776,
0.031169167,
-0.019860595,
0.008975591,
-0.0024371922,
0.01457609,
-0.049322046,
0.012525487,
-0.0251451,
0.017332638,
0.011221169,
-0.016041767,
0.0029784169,
-0.0050727213,
-0.020667389,
-0.015840068,
0.02156831,
-0.0021665797,
0.00022396956,
-0.0030372457,
-0.03323994,
0.01005804,
-0.03428877,
0.025252672,
0.013473471,
-0.008471344,
0.02718898,
0.023639083,
-0.0026859539,
0.011194276,
0.012115366,
-0.018085647,
0.020855641,
0.0046659624,
0.04499225,
-0.010911898,
0.006538398,
0.0044777105,
-0.025212333,
0.018959673,
0.005341653,
-0.0032540718,
0.017036814,
0.0075637,
-0.010165612,
0.0016051852,
0.019363072,
0.01402478,
0.0075569763,
0.004514688,
0.031061593,
-0.009338648,
0.016203126,
-0.014750895,
0.026220826,
0.010279909,
-0.008894911,
0.015759388,
0.00031599458,
0.025091313,
0.01921516,
-0.007476297,
-0.007946927,
-0.019712683,
-0.0044474555,
-0.010858111,
0.0012236385,
0.011268232,
0.0074628503,
0.014939147,
-0.015275312,
-0.0636292,
-0.019040354,
-0.013836528,
-0.034557704,
0.016283805,
-0.0178705,
-0.010010977,
0.031169167,
0.017964628,
0.03159946,
-0.016256912,
-0.045395646,
0.026140146,
0.0004861778,
0.00705273,
-0.027834415,
-0.022146514,
0.0007698166,
0.010656413,
0.006155171,
0.008431004,
0.027323445,
-0.027256213,
-0.0019884126,
-0.011174106,
-0.0044407323,
0.041334778,
-0.0066426094,
-0.008827678,
-0.01449541,
-0.014683662,
-0.008202412,
-0.030792663,
-0.012175876,
0.010387481,
-0.0002009633,
-0.0070392834,
-0.012283448,
-0.000864783,
0.037031874,
0.038376532,
-0.013312112,
-0.0007290566,
-0.022644036,
0.015920747,
-0.0050794445,
0.006373678,
0.0086864885,
0.03563343,
0.008881465,
-0.0061114696,
-0.012243109,
-0.010031147,
-0.0045314967,
0.038806822,
0.02181035,
0.009110056,
0.020721175,
0.029313538,
-0.009291585,
-0.013540704,
0.0015850153,
0.010226122,
-0.0032019662,
-0.0060744914,
-0.0065955464,
0.020963214,
0.014011334,
0.0019984976,
0.0075771464,
0.018596616,
-0.0057954746,
0.0026960387,
-0.013271771,
0.018529383,
0.0178705,
0.025790535,
0.011395974,
0.03017412,
-0.025010634,
0.004101206,
0.05351738,
0.001427018,
0.010474884,
-0.01204141,
-0.0045113266,
-0.01005804,
0.026409078,
-0.004507965,
0.0005857665,
-0.0019245414,
-0.009210905,
0.026449418,
0.015611476,
0.019887488,
0.014159246,
0.010669859,
0.007852801,
-0.00041453275,
-0.011927114,
0.0048239594,
-0.0020489222,
-0.0068779243,
-0.008726829,
0.0261267,
0.00625602,
-0.01858317,
-0.020842195,
0.012276725,
0.0004916405,
0.014145799,
-0.025978787,
-0.0014791235,
-0.0083704945,
-0.017574677,
-0.015692156,
0.0070930696,
0.0027195702,
-0.024055926,
-0.00073830114,
-0.01011855,
-0.0074359574,
-0.03157256,
-0.0042995433,
-0.009701706,
-0.01453575,
-0.051903788,
-0.014253372,
0.030120334,
0.018475598,
-0.000547948,
-0.021030447,
0.014777789,
0.020331224,
-0.01146993,
-0.011315295,
-0.014697109,
-0.022791948,
0.04902622,
0.015194632,
0.016848562,
-0.025239225,
-0.015934194,
-0.013406238,
0.023343258,
-0.02310122,
0.031922173,
0.025279565,
-0.0057551353,
0.02439209,
0.011449761,
0.0012303619,
0.01559803,
-0.029205967,
0.003630576,
-0.020492584,
-0.0060644066,
-0.003563343,
-0.007825908,
-0.012229662,
-0.00018110858,
-0.010575733,
-0.02191792,
-0.01696958,
0.034342557,
-0.02156831,
0.005129869,
0.011826265,
0.029098393,
0.017426765,
0.013056627,
0.0229802,
0.018179772,
0.0013639872,
0.004430647,
0.01952443,
0.01901346,
-0.0025498073,
-0.018300792,
0.0010463118,
0.024607237,
-0.004887831,
-0.03229868,
-0.027041066,
-0.003970102,
0.053840097,
0.014508857,
-0.011664906,
-0.039963227,
-0.011369081,
-0.016633416,
-0.00797382,
-0.009069717,
-0.022765055,
-0.010326971,
-0.009943744,
-0.026261166,
-0.007691442,
0.02377355,
-0.03383159,
0.010811049,
-0.0072544287,
0.0012354043,
0.008215859,
-0.008531854,
0.0047869817,
-0.03700498,
-0.016485503,
0.0054189707,
-0.028614316,
0.009782385,
-0.0009177289,
0.0115371635,
0.021339718,
0.0063837627,
0.026153592,
0.02271127,
0.016566183,
0.00007038443,
0.007294768,
-0.0014312201,
0.014522304,
-0.01351381,
0.023948355,
-0.006437549,
0.0030069908,
0.012391021,
-0.0077855685,
0.03990944,
0.01692924,
0.005708072,
-0.03307858,
-0.018018413,
-0.022563357,
-0.0065182284,
0.016095553,
0.020452244,
0.01854283,
-0.03751595,
0.0016833434,
0.008027607,
-0.011436314,
-0.002287599,
0.0023581935,
0.017615017,
-0.02753859,
0.004218864,
-0.029017715,
0.022227192,
0.013957547,
-0.012222939,
0.010542117,
-0.009009207,
-0.008901634,
0.021783454,
0.00901593,
0.00427265,
0.025656069,
-0.00958741,
0.0058156447,
-0.016727543,
0.0023800442,
-0.019457197,
-0.0054862034,
-0.03689741,
-0.00093453715,
0.0021817072,
-0.01410546,
0.012088473,
0.0069249873,
-0.016606523,
0.026785582,
-0.03401984,
0.0066661406,
-0.010286632,
0.0028473127,
0.019403411,
-0.01735953,
0.031922173,
0.01500638,
0.016498951,
-0.014656769,
-0.006793883,
-0.007496467,
0.010777432,
0.03504178,
0.013970993,
0.011389251,
-0.0062795514,
0.0020741345,
0.008578916,
-0.012565826,
-0.04711681,
0.025669517,
-0.002191792,
-0.026153592,
-0.0036339376,
-0.022657482,
-0.008229305,
0.016270358,
-0.04136167,
0.029958975,
0.0011589269,
-0.010044593,
-0.0045247735,
0.038860608,
-0.0178705,
0.029824508,
-0.0014824851,
0.012949054,
0.0024439155,
-0.013036457,
-0.012135536,
0.00502902,
0.0030725428,
0.025884662,
-0.0042961813,
0.013285219,
0.0051365923,
0.008780615,
-0.0013236474,
0.012935608,
-0.016256912,
0.04149614,
0.01095896,
-0.0003042288,
0.005331568,
0.014898808,
-0.0024254264,
-0.016176233,
-0.014643323,
-0.011174106,
-0.010239569,
0.006017343,
0.019806808,
0.0024187032,
-0.014885361,
-0.001823692,
-0.02769995,
0.029636256,
-0.026610777,
-0.030873341,
0.02455345,
-0.023598744,
0.001973285,
-0.011133766,
0.00603079,
0.012841482,
-0.003252391,
-0.0039196773,
-0.0036944472,
0.03001276,
-0.032406252,
0.005237442,
-0.0013059988,
0.025777088,
-0.010145443,
0.016270358,
-0.010851388,
-0.011053086,
0.025857769,
-0.01696958,
-0.03937158,
0.009688259,
-0.00860581,
0.033293724,
0.009002483,
-0.022227192,
-0.0057551353,
-0.0062896367,
-0.0014875276,
0.0064241025,
-0.013930654,
0.010253015,
-0.002306088,
0.00041201152,
0.007778845,
-0.026731797,
0.011288402,
0.013345728,
0.028829461,
-0.0064241025,
-0.038295854,
0.013547427,
0.0048441296,
0.0057416884,
-0.015772834,
0.015880408,
0.010407651,
-0.013742402,
-0.017709142,
0.01504672,
-0.014885361,
-0.018341132,
-0.01349364,
0.0003567545,
-0.0128011415,
0.017964628,
-0.0077855685,
-0.0022153235,
0.009392434,
-0.027350338,
-0.049752336,
0.008868018,
-0.043782055,
0.029394219,
0.011153935,
-0.0055635213,
-0.012189322,
-0.017399872,
-0.039613616,
0.03350887,
-0.013177645,
0.0024338304,
0.016660308,
0.014724002,
-0.0053719077,
0.02428452,
-0.02293986,
-0.0027262936,
0.017493997,
0.012431361,
0.0016413229,
-0.011927114,
0.006178702,
-0.005792113,
-0.027525144,
-0.026193934,
0.028291598,
-0.016996473,
-0.0057786666,
0.022536464,
-0.015450117,
-0.00012837279,
-0.002343066,
0.016310697,
0.0081486255,
0.009937021,
0.015934194,
-0.02148763,
0.005082806,
-0.00019161373,
0.0035364497,
-0.03009344,
-0.017399872,
-0.004998765,
-0.01300284,
0.00009365331,
-0.037408378,
-0.0051937406,
0.010925344,
-0.019107586,
0.026946941,
-0.006730012,
0.0025262758,
0.00006639247,
-0.0013144029,
-0.022832287,
-0.027592376,
0.009345371,
-0.0126128895,
0.020398458,
0.017372977,
-0.00991685,
-0.016646862,
0.021164913,
0.026691455,
-0.025978787,
-0.008780615,
-0.00852513,
-0.005822368,
-0.041523032,
0.023249133,
0.01721162,
-0.015275312,
-0.019026907,
0.010750539,
-0.0034961102,
-0.02647631,
-0.017386425,
0.014159246,
-0.007449404,
0.019080693,
-0.0018724359,
-0.009459667,
-0.029448004,
-0.014750895,
0.008041053,
-0.026906602,
-0.00950673,
0.18093714,
-0.016041767,
0.002485936,
-0.0034759403,
-0.005775305,
-0.021339718,
0.019201713,
0.007288045,
-0.020223653,
-0.009627749,
0.0023313004,
-0.001815288,
-0.014602983,
0.00423231,
0.009479837,
-0.006040875,
-0.022886075,
-0.0018556276,
-0.02726966,
-0.01670065,
0.028883249,
-0.00913695,
0.012794418,
0.0016035043,
0.008007437,
0.0042087785,
0.0077653984,
0.02105734,
0.02702762,
-0.0011933837,
-0.016445164,
0.017023368,
-0.01005804,
0.0066426094,
-0.039290898,
-0.016983027,
0.00019014301,
-0.0034053456,
0.010837941,
0.020492584,
0.009009207,
0.0029868209,
0.010320248,
0.006024067,
-0.02459379,
0.0039667403,
0.02215996,
-0.038645465,
-0.0087201055,
-0.011685075,
-0.033186153,
-0.019161373,
0.0033129004,
0.009500007,
0.004366776,
-0.0104614375,
0.013480194,
0.03923711,
-0.001285829,
-0.002541403,
-0.0070392834,
0.0017883948,
-0.0436207,
0.036924303,
0.0116312895,
0.03767731,
-0.012350681,
0.014508857,
0.0023279388,
0.02148763,
-0.0018505852,
-0.030443052,
-0.051339034,
-0.005839176,
0.0006055162,
-0.011274955,
0.0182739,
0.00057147956,
-0.0003636879,
0.030227905,
0.009284861,
-0.0024338304,
-0.01461643,
0.02207928,
-0.020788409,
-0.04461574,
0.060886104,
0.014683662,
-0.017910842,
0.012384297,
0.022025494,
0.014038227,
-0.0032557526,
0.0025834236,
0.013345728,
-0.028829461,
0.0061383625,
0.014549197,
-0.009305032,
0.006407294,
-0.02451311,
0.06610338,
0.015503904,
-0.0020354756,
-0.0022136427,
-0.0028036113,
0.010320248,
0.019806808,
0.006965327,
-0.021783454,
-0.0007958693,
-0.008854571,
-0.0054828417,
-0.008444451,
-0.015221526,
0.000043753902,
-0.023302918,
-0.01760157,
0.03407363,
0.0022270894,
-0.014992934,
-0.030147227,
0.0040978445,
0.021420397,
0.005886239,
-0.0047768964,
-0.024822382,
0.025118206,
-0.02974383,
-0.02467447,
0.014011334,
-0.02510476,
-0.006598908,
-0.009486561,
-0.01302301,
-0.011974177,
0.00997736,
-0.0074157873,
0.010205952,
0.02271127,
-0.018515937,
-0.009291585,
0.02467447,
0.01157078,
-0.0053752693,
-0.018045306,
0.032621395,
0.0103336945,
-0.030362371,
0.0061988723,
-0.0055164583,
-0.004309628,
0.015355991,
-0.0057719434,
0.023800442,
-0.045503218,
-0.009278138,
-0.017386425,
0.0047029406,
0.007684719,
-0.03912954,
0.028345386,
-0.00067779154,
-0.01052867,
-0.0033431554,
-0.009110056,
-0.16888902,
-0.004434009,
-0.003600321,
-0.026920049,
0.01054884,
-0.002929673,
0.023464277,
-0.021904474,
-0.026530096,
-0.00427265,
0.022375105,
-0.025521604,
-0.011658182,
-0.042787008,
0.0042087785,
-0.0057954746,
-0.015880408,
0.026920049,
0.037300806,
0.013836528,
0.03213732,
-0.06556551,
0.024378644,
-0.01349364,
0.033912268,
0.012868375,
-0.0037448718,
0.008693213,
-0.00251451,
-0.028937034,
-0.023302918,
0.004148269,
0.030416157,
0.0037078937,
0.016754435,
-0.013567597,
0.011174106,
-0.016445164,
-0.015288758,
0.024862722,
0.024687916,
0.009822724,
0.0055702445,
0.010306802,
-0.0034423238,
-0.0049080006,
-0.0048374063,
-0.008746998,
-0.000983281,
-0.010710198,
0.0014892084,
-0.0055702445,
-0.011832988,
0.010770708,
-0.0036944472,
-0.009553793,
0.014011334,
0.009318478,
-0.013204539,
-0.007846078,
0.0014976126,
-0.00991685,
0.03571411,
0.002580062,
0.0067737135,
-0.015961086,
0.013439854,
-0.008572193,
-0.034315664,
0.007402341,
-0.03194907,
-0.0019480729,
0.009251245,
-0.02164899,
0.013930654,
0.023692869,
-0.010898451,
0.011557333,
-0.013130583,
-0.009863065,
-0.0065451213,
0.03248693,
-0.03213732,
-0.0249434,
-0.025091313,
0.003432239,
0.024701362,
-0.014132353,
0.013265048,
-0.038672358,
-0.0028624402,
-0.030765768,
0.01508706,
-0.0071603023,
0.024580343,
0.018233558,
-0.005671094,
0.014683662,
0.011732139,
0.008726829,
0.004383584,
-0.0048609376,
-0.02109768,
0.003354921,
0.026449418,
-0.0074292338,
-0.016162787,
0.0115035465,
0.037623525,
-0.012653229,
-0.0049954033,
0.016270358,
-0.012653229,
-0.01202124,
0.0014648365,
0.024916507,
-0.004124738,
0.010676582,
0.023558404,
-0.009768939,
0.07368724,
-0.010763985,
0.004434009,
0.03358955,
-0.00423231,
-0.02113802,
-0.12801142,
-0.0290715,
0.002287599,
0.007126686,
-0.0029464813,
0.00862598,
0.0035364497,
0.008538577,
-0.008000714,
0.025723303,
-0.04294837,
-0.02310122,
0.009641196,
-0.016498951,
0.008787339,
0.039855655,
0.02804956,
0.016566183,
-0.04160371,
0.043459337,
0.010763985,
0.008794062,
0.002911184,
-0.0033582826,
-0.0058660693,
0.00051727303,
-0.018892441,
0.00036725964,
-0.0039499323,
0.0009244522,
0.02659733,
-0.009634472,
0.0047600884,
0.0241635,
-0.005650924,
0.01310369,
0.014629876,
0.0022791948,
0.030281693,
-0.04192643,
0.005160124,
0.0030775855,
0.020667389,
0.040366624,
-0.00073283847,
-0.018300792,
-0.046014186,
0.0011337146,
0.020425351,
-0.022092726,
-0.008894911,
-0.037704203,
-0.0030002675,
0.00089671864,
0.022845736,
0.0032843265,
0.007819185,
0.01594764,
0.002079177,
-0.0017631825,
0.013849975,
-0.026422525,
-0.024956847,
-0.00112447,
0.0064509953,
-0.011799372,
-0.025171993,
-0.04397031,
0.004131461,
-0.020048847,
0.004840768,
-0.011880051,
-0.016956134,
0.004965149,
-0.05012884,
0.009863065,
0.01402478,
-0.021743115,
-0.0013891995,
0.0043802224,
-0.014979487,
-0.0011858201,
-0.003976825,
0.005012212,
0.036198188,
0.027431019,
0.017265406,
0.0012774249,
0.008491513,
-0.013056627,
0.017238513,
0.007314938,
-0.0011185871,
0.0065249517,
0.0030204374,
0.0048710224,
-0.014643323,
-0.0018203304,
0.032352466,
0.04800428,
-0.0159073,
-0.028399171,
-0.035149354,
0.02635529,
0.0088142315,
-0.02659733,
0.014011334,
-0.0012312023,
0.014939147,
0.0016623331,
-0.007819185,
-0.0035095566,
-0.020008506,
0.0037583183,
-0.011678352,
-0.023276025,
-0.03315926,
-0.018825209,
0.027941987,
-0.008128456,
0.029555578,
0.019968167,
0.01449541,
-0.012296895,
-0.011120319,
0.03587547,
-0.011557333,
-0.0012135536,
0.0039667403,
0.006719927,
-0.0031229677,
-0.00019108847,
0.0087201055,
-0.04397031,
-0.008303261,
-0.008303261,
-0.015234972,
-0.01799152,
0.011221169,
0.026368737,
0.009674813,
0.03178771,
-0.0020825386,
-0.021460738,
0.0019699235,
-0.020290885,
0.01255238,
-0.020721175,
-0.028022667,
0.018771421,
-0.0056946254,
-0.0018220112,
0.009432774,
0.009271415,
0.0031414565,
-0.013849975,
-0.043163512,
0.029609364,
-0.020882534,
0.012875098,
-0.00580556,
-0.027565483,
0.008861294,
-0.021191806,
0.006397209,
-0.008350325,
-0.0019968168,
-0.02152797,
-0.023639083,
-0.005620669,
-0.00010232005,
-0.0018253729,
-0.020438798,
0.00033826547,
0.015732495,
0.013762572,
0.013157476,
0.0059131323,
-0.0116312895,
0.016983027,
-0.026288059,
0.025252672,
0.008336878,
-0.02353151,
-0.02388112,
-0.009970637,
0.028237812,
-0.0023380236,
-0.012875098,
0.015342545,
-0.031061593,
0.0051332307,
-0.0077922917,
-0.005348376,
-0.0040911213,
0.020411905,
0.0028052921,
0.017695695,
-0.016781328,
-0.016498951,
0.0071334094,
0.015961086,
0.010481607,
0.0069787735,
0.017386425,
-0.010474884,
-0.011759032,
0.0024624045,
-0.018556276,
-0.021514524,
-0.0039734636,
0.043889627,
0.01960511,
0.042598758,
-0.006467804,
-0.0038121047,
-0.019282391,
0.017588124,
-0.0143206045,
0.017937735,
-0.011792649,
0.00625602,
0.015813176,
0.0027330169,
0.01854283,
-0.003449047,
0.023302918,
0.005150039,
0.012108643,
-0.0052979514,
0.007758675,
0.01351381,
0.013137306,
-0.009856341,
-0.04442749,
0.004000357,
0.002211962,
-0.0341812,
-0.012444807,
0.04068934,
0.0056173075,
0.06631852,
-0.0073687243,
-0.027525144,
0.0012564146,
-0.019295838,
0.012545656,
-0.004981957,
0.010387481,
-0.002958247,
-0.023397045,
0.012276725,
-0.023625636,
0.03436945,
-0.043755163,
-0.024755148,
-0.0075838696,
0.007960374,
0.022025494,
0.0031347333,
-0.014401284,
0.018946227,
0.014145799,
0.04867661,
0.00061518094,
-0.010219399,
0.0064946967,
0.023934908,
-0.022415444,
-0.009251245,
-0.032191105,
-0.0026994003,
0.005597138,
-0.027726842,
-0.0022338126,
0.001564005,
-0.005082806,
-0.0040272498,
-0.0075637,
0.0104614375,
0.0028405895,
-0.010743815,
0.016593076,
-0.021514524,
-0.0070460066,
-0.015987981,
0.00750319,
-0.012343958,
-0.015275312,
-0.036628477
] |
The short stem and midrib (ssm) mutants of Arabidopsis thaliana show both semi-dwarf and wavy leaf phenotypes due to defects in the elongation of the stem internodes and leaves. Moreover, these abnormalities cannot be recovered by exogenous phytohormones. ssm was originally identified as a single recessive mutant of the ecotype Columbia (Col-0), but genetic crossing experiments have revealed that this mutant phenotype is restored by another gene that is functional in the ecotype Landsberg erecta (Ler) and not in Col-0. Map-based cloning of the gene that is defective in
|
[
-0.01625271,
0.00776351,
-0.010529346,
-0.018087473,
-0.04907305,
0.037872784,
-0.021181922,
0.020921769,
-0.022893455,
-0.018019011,
0.02196238,
-0.0024868562,
0.0063942843,
0.02079854,
-0.0010389,
0.014623331,
0.016718246,
-0.0028805085,
0.0015232636,
0.012398339,
-0.004415753,
0.023756066,
0.006866667,
-0.006531207,
0.004508176,
0.024906216,
0.03171127,
-0.032122035,
-0.027507745,
0.00074836746,
0.013692257,
-0.009632503,
-0.015800865,
-0.01510256,
-0.016389633,
-0.0035599868,
0.01740286,
-0.018429779,
0.023427453,
-0.015335328,
0.005538518,
0.0034846794,
-0.016006248,
-0.005589864,
-0.012459954,
-0.006976205,
-0.006544899,
-0.018676238,
-0.0041282154,
0.024919908,
0.0082906615,
0.031930342,
-0.038968164,
0.0011912264,
-0.025056832,
0.00870143,
0.0024337987,
0.0019066469,
0.007845663,
0.014157794,
0.011816418,
0.008893121,
-0.030314658,
0.003186873,
-0.025768828,
-0.013904488,
-0.00011659813,
-0.0019956464,
-0.01222034,
0.00047109922,
0.028123897,
0.024194218,
-0.010255501,
-0.012213494,
0.005531672,
-0.015129944,
-0.023564374,
0.018292855,
-0.02153792,
-0.011152344,
0.019223928,
-0.025672983,
-0.010775806,
0.018402394,
0.024741909,
0.007564972,
0.0031372386,
-0.009837887,
-0.006271054,
0.006438784,
0.01934716,
0.03549033,
-0.006175208,
-0.00063412264,
-0.02742559,
-0.0075307414,
-0.0009362081,
0.014842407,
-0.004463676,
-0.02954789,
-0.015431174,
0.01170688,
-0.00057721423,
-0.012405185,
-0.02875374,
-0.0077429716,
0.0019015123,
0.020634232,
0.024481757,
-0.036722634,
-0.015732404,
0.0054529416,
0.0022284149,
-0.030533735,
0.022948224,
-0.00992004,
0.025138985,
0.013254105,
0.0071062814,
-0.014185179,
0.018594086,
0.02007285,
0.024591295,
-0.040173084,
0.012199801,
0.012418877,
-0.02038777,
0.009632503,
-0.049155205,
-0.011234497,
0.011302958,
0.030862348,
0.002827451,
-0.009125889,
-0.007777202,
0.0048641744,
-0.018772084,
-0.032067265,
-0.025125293,
-0.045157064,
0.007777202,
0.011754803,
-0.032478034,
0.011426189,
0.001810801,
0.0070378203,
0.015595481,
0.003512064,
-0.0006174352,
-0.0069317054,
0.003277584,
-0.015869327,
0.010953805,
-0.014089333,
0.02366022,
0.026672518,
0.0041111005,
0.023126222,
-0.04228169,
-0.008051047,
-0.020839615,
0.0060485546,
-0.020579463,
-0.0020983384,
0.0070583588,
0.033025723,
-0.022633301,
-0.014212563,
-0.0005720796,
0.0004492772,
0.0141167175,
0.0155407125,
-0.02177069,
0.011234497,
-0.00071285316,
-0.0035428717,
-0.00985158,
0.01443164,
-0.0068906285,
-0.033819877,
-0.02880851,
0.019716851,
0.008030509,
0.010193885,
-0.02171592,
-0.0034042376,
0.024139449,
0.022441609,
0.003666102,
-0.0060348623,
-0.027672052,
0.00794151,
0.011131805,
0.0044362913,
-0.63006294,
-0.038338322,
-0.008708276,
-0.026398672,
0.028562048,
0.020278232,
-0.008359123,
0.0030191427,
-0.016321171,
-0.0041042543,
-0.0099816555,
0.0026734131,
0.020264542,
-0.013418412,
-0.0043267533,
-0.021606382,
-0.010207578,
-0.020949153,
0.029219277,
0.005586441,
-0.025494983,
0.020264542,
-0.010755268,
0.029137123,
-0.0041419077,
-0.0017483301,
0.016773015,
0.0011107844,
-0.011508342,
0.019333467,
-0.021934995,
0.028370358,
-0.002794932,
0.020839615,
0.050606582,
0.023619143,
-0.020771155,
0.01649917,
0.027630975,
0.03250542,
-0.010036425,
0.008461815,
0.016143171,
-0.0031269693,
-0.021250384,
0.019114392,
0.015253175,
-0.005069558,
0.015609173,
-0.023728682,
0.017087936,
0.02190761,
-0.0035394486,
0.0031594883,
0.024235295,
0.014281024,
0.022290995,
0.0073801265,
0.0189227,
0.022879763,
-0.010022732,
0.046389367,
-0.011878033,
0.010180193,
0.017101629,
-0.0036489866,
-0.0071542044,
0.011412497,
0.0062539387,
-0.013863411,
0.01374018,
0.035572484,
-0.011097575,
0.022948224,
-0.001437687,
0.037078634,
-0.0029900467,
0.011816418,
-0.0013024759,
0.0058602863,
-0.0045458293,
0.0034624296,
-0.018909007,
0.0021993187,
0.031629115,
-0.0043952144,
-0.020867,
-0.0011244767,
-0.025152676,
-0.008831506,
0.0014479562,
0.00483679,
-0.006449053,
-0.05471426,
-0.014828715,
0.013151413,
-0.017416552,
0.027261285,
-0.0033426224,
-0.02286607,
-0.01934716,
0.0044910605,
0.00073082425,
0.0034453142,
0.00767451,
0.031820808,
-0.025563445,
0.0021205884,
0.017512398,
-0.014965638,
0.024481757,
0.0037037556,
-0.014267332,
0.0048230975,
-0.026768362,
-0.02765836,
0.021072384,
0.0022267033,
-0.010816883,
-0.006531207,
0.019538851,
-0.0073527424,
-0.0022027418,
-0.0037379863,
-0.006565437,
0.008769891,
0.012124494,
-0.02650821,
0.009146428,
-0.0034641412,
-0.014527485,
-0.023304222,
0.0146507155,
-0.02504314,
0.010508807,
-0.01395241,
0.0032296611,
0.010262347,
0.017923165,
-0.012227186,
-0.023071453,
-0.01298026,
0.0072705885,
-0.02031931,
-0.013774411,
-0.030643271,
-0.018785777,
-0.011720573,
0.001807378,
-0.030040812,
-0.019429313,
0.0038714858,
-0.015143637,
0.0071610506,
-0.0022044533,
-0.0034008145,
-0.03768109,
-0.019730544,
-0.0189227,
-0.0018792623,
0.012179263,
0.005795248,
-0.019251313,
0.0050592893,
0.0009490446,
-0.009235428,
-0.00916012,
-0.008283815,
-0.016937323,
-0.029301431,
-0.017060552,
-0.019812696,
-0.007078897,
-0.017580858,
-0.030533735,
0.0374894,
-0.0044842144,
0.003720871,
-0.031136192,
-0.0068461285,
-0.0035565638,
-0.008920506,
-0.009468196,
-0.010050117,
0.017361782,
0.017827319,
0.020428848,
-0.004316484,
0.0137607185,
0.0145001,
0.011234497,
-0.0010637173,
0.01510256,
0.02765836,
-0.0025809905,
-0.01149465,
0.017758857,
0.0055932873,
0.011248189,
0.057233635,
-0.0057781325,
-0.012939183,
0.008975275,
-0.016334863,
0.01480133,
-0.03543556,
0.004251446,
-0.021880228,
0.01947039,
0.03499741,
0.014075641,
0.014938253,
-0.009064274,
-0.0096256565,
0.008715122,
-0.00066578604,
0.00088914094,
0.0056685945,
-0.00028625375,
-0.0040563312,
-0.02456391,
-0.0052817883,
-0.007927817,
-0.017101629,
0.009646195,
0.010152808,
0.01098119,
0.009338119,
-0.002118877,
-0.0010654287,
0.0012853607,
-0.0051277503,
0.012110801,
0.0018587239,
0.0013452643,
0.02226361,
0.0065243607,
-0.020949153,
0.051400732,
-0.0041727154,
-0.0037859092,
0.025467599,
-0.0059287474,
-0.0020333002,
0.03256019,
0.0024286641,
0.047566902,
0.016773015,
0.0071610506,
-0.008852044,
-0.021140845,
0.025864674,
0.0005224452,
-0.00053570955,
-0.005011366,
0.006907744,
0.014185179,
0.043157995,
0.040556464,
0.011179728,
0.011823264,
-0.005381057,
0.014815022,
-0.017430244,
0.005747325,
0.026234364,
0.013692257,
0.0065517453,
0.009139582,
-0.020141311,
-0.0016636093,
0.02062054,
-0.014034564,
-0.031163577,
-0.015307943,
0.0020692423,
0.008564507,
0.008386508,
0.006342938,
0.026275441,
-0.008249585,
-0.017279629,
0.023797143,
0.024960985,
-0.026864208,
0.010892191,
-0.0061444007,
0.006062247,
0.0054118647,
0.025193753,
0.006558591,
-0.0001408805,
0.015266867,
0.0060519776,
-0.020702694,
0.00038145774,
0.009605118,
-0.004275407,
0.039269395,
-0.002582702,
0.0041316384,
0.0068803593,
0.0043917918,
0.009208043,
0.05186627,
0.005322865,
-0.009057428,
-0.009283351,
-0.02141469,
-0.0026049518,
-0.02875374,
-0.03699648,
-0.0008908525,
0.0154037895,
-0.0075307414,
-0.0052441345,
0.023509607,
-0.021400997,
0.02426268,
-0.022893455,
-0.007133666,
-0.035572484,
-0.018635163,
-0.0080236625,
0.032587573,
0.037133403,
-0.005076404,
0.0132267205,
0.01807378,
0.00568571,
-0.006712629,
-0.022455301,
0.014171487,
-0.012528416,
-0.025138985,
-0.01964839,
0.028589433,
0.004261715,
0.007174743,
0.025330676,
0.004696444,
-0.0313005,
-0.015677635,
0.0024526257,
0.008283815,
-0.02596052,
0.0026580095,
0.054549955,
-0.005370788,
0.021318845,
0.0018741278,
0.0037859092,
0.016362248,
-0.019675774,
-0.00031641952,
-0.0023139915,
0.0032211035,
0.0018056665,
0.019128084,
-0.015568096,
0.012672184,
0.0041795615,
-0.025453907,
-0.015198406,
0.046608444,
0.006948821,
0.009242274,
0.0056172484,
-0.00712682,
-0.017991627,
0.0042274846,
0.006062247,
-0.015020406,
-0.025275907,
0.00976258,
-0.02456391,
-0.000019054167,
-0.021647459,
0.037078634,
0.010741576,
-0.010460884,
0.014924561,
-0.010707345,
-0.0030978732,
-0.0014659273,
-0.031875577,
0.025672983,
0.006989897,
-0.017101629,
0.013199336,
0.002308857,
0.015677635,
-0.009557196,
-0.015841942,
-0.011207113,
0.010830576,
-0.02135992,
0.0106046535,
0.028972816,
0.022441609,
-0.0017312148,
-0.0041316384,
-0.015663942,
0.0024149718,
-0.0038269858,
-0.022359457,
0.0052099037,
-0.010043271,
-0.014308409,
0.033272184,
0.003515487,
-0.003614756,
-0.037927553,
0.016992092,
0.0082906615,
-0.0133157205,
0.0124257235,
-0.018977469,
-0.0066236295,
0.01243257,
0.047183517,
0.028781125,
-0.007975739,
-0.0004950607,
0.006863244,
-0.011275574,
-0.026111135,
0.010303424,
0.010289731,
-0.022222534,
-0.023454838,
-0.011118113,
-0.004148754,
-0.009584581,
0.0005802094,
-0.02559083,
-0.0046690595,
-0.003782486,
0.034531873,
0.009317582,
0.0034744104,
0.012384647,
0.013815488,
-0.00017938997,
-0.0026460288,
-0.015294251,
0.026549287,
0.017156398,
-0.028178666,
0.027822668,
-0.0122956475,
-0.009885809,
-0.028178666,
0.004248023,
-0.014719177,
0.016663477,
0.023482222,
-0.0025946829,
-0.01667717,
-0.0025313562,
0.015759788,
0.017676704,
-0.005203058,
-0.006058824,
0.0004122653,
0.007831971,
0.0058979397,
-0.02056577,
-0.0000028079824,
-0.024851447,
-0.0020778,
0.028425125,
0.02201715,
0.008461815,
0.0018296279,
0.022619609,
0.00067220425,
0.0011278997,
0.0068221674,
-0.054139186,
-0.016088402,
-0.01570502,
0.020278232,
0.02079854,
0.0080236625,
0.012398339,
0.038666934,
0.032779265,
0.0041179466,
-0.0034590065,
0.013603258,
0.010501961,
-0.026658826,
0.03299834,
0.025618214,
0.017512398,
0.009331273,
-0.012822799,
0.01814224,
0.027329745,
-0.019128084,
0.007920971,
0.022893455,
-0.04808721,
-0.010344501,
-0.00055068545,
-0.0061272853,
0.0074280496,
-0.013815488,
-0.006722898,
-0.0006045987,
-0.0025553175,
-0.012357262,
-0.010755268,
0.026343903,
-0.004049485,
0.05307119,
-0.01067996,
0.016485479,
-0.026672518,
-0.026357595,
-0.005158558,
-0.011823264,
0.024673447,
-0.017320706,
0.0072568962,
0.0048675975,
-0.016444402,
0.010919576,
0.009742041,
-0.0067023598,
-0.0075923568,
-0.012884414,
-0.0029626621,
-0.0054563647,
-0.022455301,
-0.008475508,
-0.02905497,
0.0078935865,
0.002370472,
-0.029739583,
0.026426056,
-0.047950286,
-0.014732868,
0.027069593,
0.006229977,
0.05750748,
0.00721582,
0.013267797,
0.008235893,
-0.011179728,
-0.05112689,
0.027083285,
-0.0001247279,
0.0018347625,
0.011884879,
0.0071199737,
0.0020367233,
-0.028726356,
0.02074377,
-0.00021757852,
-0.012932337,
-0.02839774,
0.016362248,
-0.01085796,
0.022715455,
-0.0068392823,
0.0041316384,
-0.0168004,
0.011658957,
-0.010303424,
0.0146781,
-0.003833832,
-0.016129479,
-0.0074280496,
0.0043746764,
0.0001869849,
0.019689467,
-0.0037037556,
-0.0073048193,
-0.007024128,
-0.02346853,
-0.03524387,
0.007407511,
0.0029130278,
0.05685025,
0.002820605,
0.004966866,
0.010577269,
0.012747492,
-0.015321636,
-0.0029404121,
-0.024221603,
0.037927553,
-0.03075281,
-0.023139914,
-0.016088402,
0.006182054,
0.0028445665,
0.007503357,
0.0012545531,
-0.026316518,
-0.005001097,
-0.0057130945,
0.036722634,
0.019401928,
0.009146428,
0.004008408,
-0.042610306,
-0.015321636,
-0.014732868,
-0.04159708,
-0.010584115,
-0.04469153,
-0.011645265,
-0.0015669077,
0.0032536227,
0.04707398,
0.009570888,
-0.022646993,
-0.007996278,
0.02965743,
-0.012275109,
0.022537455,
-0.0022557995,
-0.007400665,
0.0007971461,
0.021688536,
0.014568562,
-0.04233646,
-0.010810037,
-0.031683885,
-0.0268779,
-0.009824195,
-0.011967033,
-0.008071586,
-0.007133666,
-0.0031577768,
0.018087473,
0.0009524677,
0.012925491,
-0.009310735,
-0.021729613,
-0.005743902,
-0.020127619,
0.013575873,
0.008270123,
-0.01055673,
-0.008413892,
-0.013130874,
-0.0016105517,
0.004631406,
0.008003124,
-0.013705949,
-0.009119043,
0.01437687,
-0.0045560985,
0.009454504,
-0.014089333,
-0.0069453977,
-0.020360386,
0.013199336,
-0.01777255,
-0.017923165,
-0.021852843,
-0.00088828517,
-0.011124959,
0.026631441,
-0.018950084,
-0.014185179,
-0.010050117,
-0.012925491,
-0.033217415,
-0.008817813,
-0.013664872,
0.030780194,
0.030561117,
-0.007606049,
-0.034312796,
-0.010303424,
-0.044089068,
-0.044910602,
-0.0021377036,
-0.0016396478,
-0.0026460288,
0.032834034,
-0.016184248,
0.016047325,
-0.0135827195,
0.009338119,
-0.01868993,
0.003453872,
0.007482819,
0.0038646397,
0.005278365,
-0.0012134763,
-0.032614958,
-0.016526554,
0.015006714,
-0.009810503,
-0.01667717,
0.009310735,
-0.002762413,
0.026028981,
0.0087835835,
0.015759788,
0.00048778666,
-0.005737056,
-0.0118027255,
-0.032231573,
-0.01183011,
-0.0036900633,
0.012145032,
-0.022441609,
0.011378266,
-0.01158365,
0.01734809,
0.0016191094,
0.00085662183,
-0.029219277,
0.0006413967,
-0.008276969,
0.03444972,
0.020401463,
-0.01552702,
0.020634232,
-0.0065140915,
0.0073253578,
-0.012199801,
-0.011350881,
0.008174278,
0.009495581,
0.008229047,
0.004682752,
-0.008448123,
-0.018826853,
-0.0029215855,
-0.0030088734,
-0.011124959,
-0.016992092,
0.0016995515,
-0.0061444007,
0.030396812,
-0.0045595216,
-0.00055368064,
-0.0029250085,
-0.0007269733,
-0.021743305,
0.0016045615,
-0.004052908,
-0.00084121805,
0.013349951,
-0.011816418,
-0.033518646,
-0.018963777,
-0.00028625375,
-0.008468661,
-0.014815022,
-0.025385445,
0.015992556,
0.19848296,
0.008420738,
0.008995813,
0.03869432,
0.0061649387,
-0.022044534,
0.027466668,
0.0031560652,
-0.012240878,
0.018566702,
0.001386341,
0.0065859756,
-0.009831041,
0.010323962,
0.029520506,
-0.00903689,
-0.0065859756,
-0.016006248,
-0.02845251,
-0.0071542044,
0.018306548,
-0.01747132,
0.0041179466,
-0.021620074,
0.032423265,
-0.0096256565,
-0.034175873,
0.01685517,
0.01588302,
0.024331141,
-0.017580858,
-0.008146893,
0.01849824,
-0.008865736,
0.009680426,
-0.0076402794,
0.0155407125,
-0.00043216188,
0.011864341,
0.018566702,
-0.0048128283,
-0.006760552,
0.014883484,
0.005220173,
-0.013425258,
0.0024560487,
-0.009824195,
0.00010804047,
-0.0008758766,
-0.00017200898,
-0.03220419,
0.011467266,
0.029931275,
0.029739583,
0.015965171,
-0.004210369,
0.020004388,
0.012213494,
-0.0013931872,
0.024509141,
-0.021154538,
0.018703623,
-0.025125293,
0.0015018695,
-0.0044362913,
0.021058692,
-0.028589433,
-0.015677635,
0.009481888,
-0.023071453,
-0.0080236625,
-0.037462015,
-0.016143171,
0.010385578,
-0.029219277,
-0.022345765,
0.005805517,
0.02001808,
0.008632968,
0.029630044,
-0.0036318712,
-0.023687605,
-0.060136393,
0.00063027174,
0.009639349,
-0.0141167175,
0.015253175,
0.009967963,
-0.019169161,
-0.023605451,
0.0017115321,
-0.0048128283,
-0.009331273,
0.0005678008,
0.008694584,
-0.009865272,
0.008413892,
0.014226255,
-0.00027555667,
-0.020264542,
-0.021729613,
0.041158926,
-0.0064250915,
-0.0020572618,
-0.0026494518,
0.019223928,
0.0025416252,
-0.0034213527,
-0.009789964,
-0.014924561,
0.009598272,
-0.03853001,
0.015677635,
-0.0027521437,
0.0062128617,
0.010351347,
0.03688694,
-0.03814663,
-0.007612895,
0.00271449,
0.006377169,
-0.024522834,
-0.002772682,
0.030369427,
-0.00034145068,
0.0009944002,
-0.019333467,
0.0031286809,
-0.012261417,
-0.02141469,
0.017430244,
-0.0033477568,
0.022126688,
0.0057747094,
0.00035685446,
-0.015020406,
0.017293321,
-0.0125558,
-0.008276969,
0.00492579,
-0.0033152378,
-0.0020641077,
-0.0074622803,
-0.0016336575,
-0.000753502,
-0.014773945,
0.009057428,
0.012405185,
-0.0038201397,
-0.020360386,
-0.00955035,
-0.015855635,
-0.008865736,
-0.0007530741,
-0.009694118,
-0.025645599,
-0.006904321,
-0.017320706,
0.008571353,
0.020333001,
-0.013555335,
0.03154696,
-0.0035000832,
0.006017747,
-0.0035976407,
0.004617714,
-0.17493229,
0.0075307414,
0.013096645,
-0.03286142,
0.0058157863,
0.025440214,
0.013480027,
-0.0027572783,
-0.0142947165,
0.014623331,
0.034723565,
0.021373613,
-0.030834964,
-0.008975275,
0.0007440886,
0.009564042,
-0.014993022,
0.023509607,
0.0078114327,
0.016211633,
0.010967498,
-0.017923165,
0.021236692,
-0.014157794,
0.018019011,
0.02019608,
0.010323962,
0.0051859426,
-0.016280094,
-0.003625025,
-0.020141311,
-0.002389299,
0.019251313,
-0.026645133,
0.0062334,
-0.00313895,
-0.02251007,
0.012097109,
0.01904593,
0.033929415,
0.017293321,
0.02116823,
0.0053981724,
-0.0005344259,
-0.026823131,
0.03524387,
0.01886793,
0.00051431544,
0.018648855,
-0.025850981,
0.007393819,
0.008092124,
0.02613852,
0.011939649,
0.02159269,
0.016280094,
-0.007975739,
0.021181922,
-0.007140512,
-0.014322101,
-0.017238552,
-0.009694118,
0.014623331,
-0.008906813,
-0.0043883687,
-0.018580394,
-0.014527485,
-0.010365039,
-0.034312796,
0.010255501,
-0.018840546,
-0.0035291794,
-0.0094476575,
-0.03354603,
0.014185179,
0.019867465,
-0.022578532,
0.0048333667,
-0.016417017,
-0.010830576,
-0.019443005,
0.02541283,
-0.012192955,
0.009221735,
0.00009146,
0.032067265,
0.007948356,
0.013021337,
0.0024543372,
0.004350715,
0.007393819,
-0.025755135,
0.027384514,
-0.018717315,
0.022879763,
0.025344368,
-0.012528416,
0.003874909,
-0.0035736791,
0.003281007,
0.01510256,
0.0033922568,
-0.023358991,
0.034367565,
0.019757926,
0.020661617,
-0.02153792,
0.007968894,
0.045704756,
0.00033588818,
-0.0072705885,
-0.0073253578,
0.0029335662,
0.028425125,
-0.004087139,
0.011727419,
0.010652577,
-0.012288801,
0.008434431,
-0.024481757,
0.04263769,
0.0022010303,
0.013459489,
0.00496002,
0.017745165,
-0.034614027,
-0.11841064,
-0.028479895,
-0.00006332669,
0.027507745,
-0.0135827195,
-0.0034264873,
-0.016636092,
0.027192824,
-0.013911334,
0.023728682,
-0.026426056,
-0.023208376,
-0.0031885845,
0.0080236625,
0.025850981,
0.0125626465,
0.002978066,
0.008427585,
0.011433035,
0.03239588,
-0.020675309,
-0.010508807,
-0.013993487,
-0.0010739864,
0.022824993,
-0.0036797943,
-0.03256019,
0.024112064,
0.023947759,
0.022181457,
0.0033066801,
-0.008899967,
0.025946828,
0.0146507155,
-0.006117016,
-0.0066167833,
-0.013500566,
-0.024878832,
0.03203988,
-0.007297973,
0.0022472418,
0.013842872,
0.033080492,
-0.023208376,
0.00020730933,
-0.0037482555,
-0.0019357429,
0.025371753,
-0.0009370639,
-0.026754672,
-0.03847524,
-0.0037071786,
-0.030807579,
0.0189227,
0.020853307,
-0.02274284,
0.019141776,
0.005120904,
-0.015568096,
-0.0054769027,
-0.020538386,
0.0061957464,
-0.0075855106,
-0.0037893322,
0.0026391826,
-0.03050635,
-0.023810836,
-0.041350618,
0.03710602,
-0.025987905,
-0.0070857434,
0.012234032,
-0.018005319,
-0.004210369,
-0.026316518,
-0.0031988537,
-0.05027797,
-0.020428848,
-0.0036010637,
-0.046416752,
0.0061991694,
-0.007174743,
0.019730544,
-0.031820808,
0.02590575,
0.014897176,
0.0090916585,
-0.0027932206,
0.002425241,
-0.019429313,
0.011378266,
-0.0028086242,
0.006907744,
-0.030287273,
-0.005791825,
0.012398339,
0.009653041,
0.0054050186,
0.03737986,
-0.012514723,
-0.04093985,
-0.026179597,
-0.053290267,
0.034833103,
-0.0010517365,
-0.01337049,
-0.0030174311,
0.0021856267,
0.017649319,
-0.0033631606,
0.010323962,
0.009584581,
-0.012240878,
-0.01862147,
0.0018381856,
-0.0049908278,
-0.021181922,
-0.029712198,
0.03154696,
0.0037345632,
0.031026656,
0.026056366,
-0.010714191,
-0.022236226,
-0.0066133603,
0.035134334,
-0.0033905453,
-0.01243257,
-0.027754206,
0.00070729066,
-0.016047325,
0.0019049353,
0.012288801,
-0.039324164,
-0.019141776,
0.019853773,
-0.0056035565,
-0.0146507155,
-0.0016969842,
0.030369427,
0.023797143,
0.027548822,
-0.021086076,
-0.019607313,
0.023591759,
0.010666269,
-0.011665803,
0.023071453,
-0.03905032,
0.013165105,
0.013233567,
-0.0012160436,
0.04816936,
0.008475508,
0.0010106597,
-0.028726356,
-0.0080236625,
-0.022304688,
0.0022797608,
0.005757594,
-0.011638419,
-0.027918512,
0.027986974,
0.00776351,
0.041158926,
-0.0025878367,
-0.033217415,
-0.025467599,
-0.003933101,
-0.016896246,
0.0026426057,
-0.028890664,
-0.0138497185,
-0.00070215605,
0.013856565,
0.022290995,
0.0053639417,
0.009139582,
-0.027973281,
-0.009262812,
-0.00052372884,
0.018799469,
-0.00016238162,
0.008215355,
-0.005747325,
0.0026665672,
0.002048704,
-0.0065483223,
-0.009899502,
0.009974809,
-0.0024594718,
0.0071131275,
-0.009844733,
0.026453441,
-0.0063977074,
-0.0017406282,
0.0002637899,
0.019278698,
-0.008092124,
-0.014897176,
0.018799469,
0.014815022,
-0.006859821,
-0.0028548357,
0.00530575,
-0.025823597,
-0.013247259,
0.011316651,
-0.024221603,
-0.02408468,
-0.0024235295,
-0.011275574,
-0.013658026,
-0.006609937,
0.010748422,
0.003431622,
0.0033049686,
0.014965638,
-0.0057096714,
-0.012726953,
0.0016850034,
0.021551613,
0.024426987,
0.007099435,
-0.003508641,
0.007482819,
0.00044970508,
0.017498706,
0.019675774,
-0.028918048,
0.02093546,
-0.004576637,
0.012453108,
0.0033888337,
-0.02116823,
-0.00580894,
-0.0023687605,
0.02129146,
0.034477104,
0.014472716,
-0.01844347,
0.07191174,
0.016170556,
-0.0017098206,
-0.007859356,
-0.024591295,
0.038557395,
-0.009783118,
0.007393819,
0.009420273,
-0.035134334,
0.016403325,
-0.015280559,
0.01964839,
-0.016239017,
-0.036065407,
0.026398672,
0.003782486,
0.018032704,
-0.006219708,
-0.02074377,
0.025152676,
-0.00309445,
0.037352476,
0.023523297,
-0.020428848,
-0.025440214,
0.030999271,
-0.008865736,
0.013391027,
-0.008543968,
0.008133201,
0.00007482605,
-0.048005056,
-0.016690861,
0.0051345965,
-0.01343895,
0.0070104357,
-0.004504753,
0.0268779,
0.009310735,
0.006274477,
-0.006332669,
-0.02159269,
-0.032779265,
0.0011236209,
-0.0065517453,
-0.0003771789,
-0.009789964,
-0.016595015
] |
CD8(+) T cells are required for protective immunity against intracellular pathogens such as Listeria monocytogenes. In this study, we used class Ia MHC-deficient mice, which have a severe reduction in circulating CD8(+) T cells, to determine the protective capacity of class Ib MHC-restricted T cells during L. monocytogenes infection. The K(b-/-)D(b-/-) mutation was backcrossed onto a C.B10 (BALB/c congenic at H-2 locus with C57BL/10) background, because BALB/c mice are more susceptible to L
|
[
-0.039153453,
-0.0048295157,
-0.0023671093,
-0.025008654,
0.0020029387,
0.02954207,
-0.017847767,
0.007984527,
-0.0081547005,
-0.008365715,
0.01048267,
-0.0060377456,
0.006085394,
-0.0017919239,
-0.013967817,
0.031393554,
0.028806921,
0.02096534,
-0.005271966,
-0.017167073,
-0.019345291,
0.020175736,
0.015819302,
-0.0119597735,
0.015029698,
-0.0009699873,
0.005687189,
-0.040569294,
-0.029215336,
0.0036689343,
0.02142821,
-0.005687189,
-0.012939971,
-0.0028929445,
-0.007065592,
-0.030277217,
0.0331089,
-0.011680689,
0.041576717,
0.027009891,
0.004383662,
0.028670782,
0.0027006487,
0.0059798867,
0.02125123,
0.0052685626,
-0.0013188424,
-0.013913361,
-0.0015485762,
-0.0062215324,
0.011605813,
-0.015587866,
-0.008508661,
0.016962865,
-0.030358901,
-0.013191828,
0.0077598984,
0.00782116,
0.003010364,
-0.034933157,
-0.00059858424,
-0.013845292,
-0.021115093,
0.0023347763,
0.01163304,
0.0065142303,
0.0017698014,
0.00782116,
0.0065822997,
0.0019229572,
0.014430688,
0.025267318,
-0.009400368,
0.008991952,
0.035232663,
-0.011176976,
-0.013715961,
0.021891082,
0.016717816,
-0.00097339076,
0.01644554,
-0.020339102,
-0.027077962,
0.030059395,
0.017507419,
-0.0026410883,
0.010884278,
0.016540837,
0.014212866,
0.00042819834,
0.0000805132,
0.018868806,
0.032782167,
0.015928213,
-0.0028027527,
0.017017322,
-0.0049758647,
0.026315585,
-0.007909651,
-0.012688114,
-0.008740096,
-0.0057586613,
-0.010258041,
-0.020379944,
-0.02845296,
-0.012517941,
-0.005734837,
0.0046219043,
0.029269792,
-0.02121039,
-0.029514842,
0.017044548,
-0.008481433,
-0.06741582,
0.0031465027,
0.0025508965,
0.007031557,
-0.0089170765,
-0.0038561248,
0.0030971523,
0.012436259,
0.010162744,
-0.00997215,
-0.016323015,
0.02125123,
0.0258391,
-0.02555321,
-0.01429455,
-0.022176974,
-0.0073719034,
0.010870664,
0.015832916,
0.018297024,
0.006772894,
-0.008270418,
0.015683163,
-0.021019794,
-0.002756806,
0.005615716,
-0.024123754,
-0.004237313,
0.024082912,
0.027159644,
-0.009114477,
0.0147029655,
0.014784648,
0.033163354,
0.018419549,
-0.021823013,
-0.0007232361,
-0.026070535,
-0.024396032,
0.00094190874,
-0.032346524,
0.020379944,
0.012545169,
-0.02209529,
0.016935637,
0.00571782,
-0.036702957,
-0.023946773,
-0.019508656,
0.022830438,
0.01852846,
0.042366322,
0.035341572,
0.006197708,
0.019903459,
0.005748451,
0.00069898646,
0.013389228,
0.029079199,
0.004689974,
0.029024743,
-0.022258656,
0.03024999,
0.004070543,
0.024722764,
-0.010421407,
-0.010516704,
-0.0068001216,
0.028153457,
0.01588737,
0.003366026,
-0.017207915,
0.0072902204,
0.026846526,
-0.030032167,
-0.001987623,
-0.0032571151,
0.0049282163,
0.006541458,
-0.0058709756,
-0.01927722,
-0.61469287,
-0.021700488,
0.024273507,
0.00045180987,
-0.023851477,
0.027336624,
0.000819384,
-0.009230195,
-0.007698636,
0.040896025,
0.0077190567,
0.009550121,
0.015628707,
-0.028507415,
-0.03215593,
-0.035886128,
0.026710387,
0.0044313106,
-0.000060677387,
-0.008978339,
-0.013790837,
-0.024382418,
-0.0026785263,
0.019032171,
-0.017180687,
0.009910888,
0.034361374,
-0.0041488227,
0.00025674884,
0.038363848,
-0.012858287,
0.01602351,
0.0036485137,
-0.033381175,
0.054618794,
0.0031975545,
-0.023878705,
0.021795785,
0.02185024,
0.03248266,
-0.016391084,
-0.01471658,
0.0222042,
0.001194616,
-0.016295787,
0.027009891,
-0.005534033,
0.033163354,
0.00031248055,
-0.010407793,
0.0026785263,
0.0073446757,
-0.028099,
0.00039076022,
0.0047920775,
-0.00038990937,
0.017589103,
-0.019753706,
0.0007479113,
0.0022599003,
0.002673421,
0.011333535,
-0.021632418,
-0.01792945,
-0.028126229,
-0.011340342,
-0.001219291,
-0.0038833527,
0.015138608,
-0.0039241943,
0.024722764,
0.015669549,
-0.007855196,
0.012708535,
0.016568063,
0.04285642,
-0.008869427,
-0.0048499363,
-0.004281558,
0.015492569,
0.0019331677,
-0.02185024,
-0.010101481,
0.014076728,
0.012994426,
-0.017915836,
-0.011163362,
0.010142324,
-0.0062079187,
0.005169862,
0.021414597,
0.009277843,
-0.009590962,
-0.047240082,
-0.025634892,
0.018256182,
-0.011680689,
-0.013838486,
-0.0060139215,
-0.006977102,
-0.018269796,
0.0014379636,
0.025321774,
-0.01500247,
0.03240098,
0.003784652,
-0.015941827,
0.014063114,
0.02965098,
-0.025226478,
-0.0011393096,
-0.022680685,
-0.005299194,
-0.007331062,
0.0139405895,
-0.011755565,
0.02125123,
0.02209529,
0.006116025,
-0.015179451,
0.02125123,
-0.0064529683,
0.008569923,
-0.015819302,
0.0020369734,
0.02470915,
0.0023603025,
-0.014743807,
0.008719675,
-0.013042075,
0.018147271,
0.004550432,
0.02530816,
-0.020938111,
0.036457907,
0.029623752,
0.032673255,
-0.008195542,
0.0008529932,
-0.019113855,
-0.039561868,
-0.021795785,
-0.0079913335,
-0.012170788,
-0.012007422,
0.0060956045,
0.004560642,
-0.0031090647,
0.0087605165,
-0.015124995,
0.017017322,
-0.00693626,
0.005435332,
0.0057008024,
0.03776484,
-0.018855192,
-0.0044585383,
-0.009359526,
0.016785886,
-0.013137372,
-0.0009767942,
0.0046219043,
0.0006096455,
0.030930683,
-0.01378403,
-0.009100864,
0.02978712,
0.017303212,
-0.006789911,
-0.034742564,
-0.017507419,
-0.018188113,
-0.008978339,
0.010469056,
0.008780938,
0.013586629,
-0.0063236365,
-0.00015538941,
-0.0033200793,
0.0008432083,
0.018896034,
-0.026710387,
0.006606124,
-0.0048397263,
0.023919547,
-0.003207765,
0.009604576,
-0.009856433,
0.012191209,
0.041304443,
0.010496284,
-0.0066605792,
-0.018147271,
0.0062215324,
0.02364727,
-0.00928465,
0.025008654,
0.016935637,
0.007916458,
0.017561875,
0.0016923726,
-0.013219055,
0.005380877,
-0.028153457,
0.029242564,
-0.041304443,
0.0065891067,
-0.026315585,
0.028126229,
0.020842815,
-0.00016836512,
0.010931927,
0.003696162,
0.00398886,
0.015193064,
0.012517941,
-0.0060717803,
-0.0005726328,
-0.0071949232,
-0.016105192,
-0.0060309386,
0.026070535,
0.029378703,
-0.018596528,
-0.009699873,
0.002668316,
0.026465338,
0.022789596,
-0.012926357,
0.003156713,
-0.012463486,
0.0061262357,
0.025349,
-0.009992571,
0.022422021,
0.0034068676,
0.017983904,
-0.0026121587,
0.053638596,
-0.01684034,
-0.0147029655,
0.016391084,
-0.0016583379,
0.011564971,
0.00020856854,
0.000025871646,
0.021115093,
0.0054319287,
-0.013396035,
0.016568063,
-0.018147271,
-0.0028418927,
-0.030467812,
0.00459808,
-0.009543314,
-0.023688111,
0.016908411,
0.005152845,
0.04359157,
0.019331677,
0.005006496,
-0.014185639,
0.017738855,
-0.022245042,
0.017139846,
0.006864787,
-0.01877351,
-0.005278773,
-0.0051392308,
-0.0015587866,
-0.049282163,
-0.006548265,
0.008168314,
-0.020094052,
0.013368808,
0.020516083,
-0.0015698478,
0.008706061,
0.025498753,
-0.00312438,
-0.033626225,
-0.039398503,
0.021387368,
0.028371278,
-0.012586011,
-0.014430688,
-0.032782167,
-0.00433261,
-0.016227717,
0.019617567,
0.019821776,
0.011408412,
0.012579204,
0.013498139,
-0.004169244,
-0.0075556906,
0.029215336,
0.0004858445,
0.031202959,
0.005227721,
-0.00055689184,
0.016350241,
-0.015356431,
0.0041420157,
0.025471525,
0.0010754947,
0.008467819,
-0.01152413,
-0.0101287095,
-0.0037370038,
0.014879946,
-0.009209774,
0.007501235,
-0.011476481,
0.011530937,
0.005571471,
-0.013593436,
0.014321777,
0.009584155,
0.0086107645,
-0.0025015462,
-0.029351475,
0.0020624993,
-0.027350238,
0.0029950484,
0.014376232,
-0.018310638,
0.015016084,
0.0011656865,
0.030957911,
-0.01334158,
-0.014376232,
0.048601467,
-0.0079981405,
-0.014730193,
0.018542074,
-0.004502783,
0.007875616,
0.0018395724,
0.01387252,
-0.009352719,
-0.0062351464,
0.009448017,
0.017139846,
0.0025883345,
0.015533411,
0.02978712,
0.018433163,
0.016949251,
-0.007569304,
-0.0023041454,
0.014185639,
-0.00910767,
-0.019998755,
-0.0036757414,
-0.00033141233,
0.021782171,
-0.010993189,
0.0064393543,
-0.023837863,
-0.000977645,
0.021999992,
0.00571782,
-0.0009767942,
0.048301965,
0.029405931,
0.0050677583,
0.019467816,
0.01888242,
-0.004250927,
-0.000031641583,
0.014975242,
0.0020539907,
-0.025267318,
0.0448985,
-0.0156150935,
-0.01573762,
-0.021632418,
0.017235143,
0.0077122496,
-0.014457916,
-0.00782116,
-0.013532174,
0.014730193,
-0.01422648,
-0.021101478,
0.020788359,
0.0034698318,
-0.02608415,
0.0047818674,
-0.00485334,
0.0035906548,
-0.053311862,
-0.021754943,
0.009495665,
-0.01644554,
-0.0222042,
0.0071676956,
0.0011639848,
0.020420786,
0.012586011,
-0.006044552,
-0.0021169547,
0.024436872,
-0.0018446776,
-0.015792074,
0.01212314,
-0.033598997,
0.026179446,
0.012878709,
0.030440584,
0.00046202025,
-0.024559397,
-0.016404698,
-0.004203278,
0.0028112615,
-0.003049504,
-0.0041522263,
-0.0022718124,
-0.015819302,
-0.00641553,
0.02785395,
-0.025975239,
-0.023102716,
-0.014675737,
-0.013756802,
-0.026465338,
-0.006606124,
-0.014158411,
-0.049717806,
-0.0018838175,
0.010258041,
0.0034187797,
0.010394179,
0.00735829,
-0.02905197,
0.008202349,
-0.012245664,
0.014485144,
0.025988853,
0.004696781,
0.019644795,
0.022081675,
-0.020665834,
-0.018092815,
-0.012129947,
0.022612616,
0.00859715,
-0.009543314,
0.015356431,
-0.0019212555,
-0.034143552,
-0.019331677,
-0.04144058,
-0.013103337,
0.011442447,
0.010843437,
-0.018051974,
-0.018582914,
-0.007051978,
0.008127472,
0.019426974,
0.0038118798,
-0.012211629,
-0.025117565,
0.016254945,
0.0073719034,
-0.016254945,
0.010251234,
-0.035069294,
-0.014961628,
0.042311866,
-0.0010184867,
0.015029698,
-0.002535581,
-0.017888607,
-0.02943316,
0.0022292691,
-0.029868802,
-0.050779685,
-0.008270418,
-0.0014966733,
0.04988117,
0.027758654,
0.01832425,
-0.016813112,
0.03441583,
0.015928213,
0.011374378,
0.008134279,
-0.019141082,
0.026914595,
-0.014839103,
-0.004223699,
0.0048873746,
-0.016990094,
0.0044585383,
-0.027418308,
0.028861376,
0.0139405895,
-0.0050167064,
-0.014185639,
-0.009298264,
-0.0041964715,
-0.015478956,
0.016186876,
-0.012095911,
0.009482051,
-0.04380939,
-0.017262371,
0.024014844,
-0.014240094,
-0.0022156553,
0.010768561,
0.035695534,
-0.023674497,
0.021768557,
-0.010714105,
0.007970913,
0.0075488836,
-0.0024726167,
-0.00075897254,
0.0067218416,
0.016214103,
0.024042072,
-0.011333535,
0.017425736,
-0.028153457,
0.013123758,
-0.0013222458,
-0.015043312,
-0.021373754,
-0.029487614,
-0.019249994,
-0.040106423,
-0.025144793,
-0.02238118,
0.0061466563,
0.010959155,
0.0095160855,
-0.01655445,
0.01205507,
-0.018092815,
-0.03226484,
0.0074672005,
-0.00009465885,
0.028561871,
-0.034715336,
0.01877351,
0.01223205,
0.0050677583,
-0.01343007,
-0.028779693,
-0.006738859,
-0.0063236365,
0.030195534,
0.023279695,
-0.011265467,
-0.012000615,
-0.0073787104,
0.024722764,
0.0028555065,
-0.02756806,
0.033762366,
0.0062861983,
-0.000031269326,
-0.017153459,
-0.012157174,
-0.032618802,
0.005367263,
-0.0076509877,
0.00083044526,
0.0061262357,
-0.02096534,
-0.016704202,
0.021768557,
0.0055034016,
0.009863239,
0.0020982358,
-0.024573011,
0.01684034,
-0.046641074,
-0.012545169,
-0.011871283,
-0.013790837,
0.023769794,
0.021550735,
0.013967817,
0.008025369,
-0.014280936,
0.011558165,
0.0033183775,
-0.0096794525,
0.043482658,
-0.012000615,
0.001651531,
-0.011939352,
-0.0039207907,
0.00545235,
-0.0062181293,
0.0004135209,
-0.0033234828,
-0.014199252,
-0.004918006,
0.024137368,
0.004809095,
0.0070860125,
0.007133661,
-0.021972764,
-0.019903459,
-0.03830939,
-0.04013365,
0.021033408,
-0.035641078,
0.006289602,
-0.0067694904,
0.0013520261,
0.020107666,
0.0067048245,
0.011231432,
0.0013647891,
0.03000494,
-0.018297024,
0.025498753,
0.0071949232,
0.009870046,
-0.02375618,
-0.0021816206,
-0.0014949717,
-0.025879942,
0.0074603935,
-0.01500247,
-0.036131177,
-0.036267314,
-0.013171406,
0.008038983,
0.020788359,
-0.02023019,
0.03000494,
0.008025369,
0.03847276,
0.008481433,
-0.027159644,
0.052467804,
-0.028779693,
-0.02107425,
0.019535884,
-0.018011132,
-0.013538981,
-0.0066810003,
-0.0017953274,
0.002438582,
-0.02322524,
-0.016922023,
-0.012048263,
-0.004662746,
-0.0009853028,
0.0078075468,
-0.007031557,
0.0021935327,
-0.010972769,
-0.023007417,
0.005329825,
-0.007147275,
-0.012783412,
-0.024409644,
-0.008712868,
0.029923256,
-0.0244641,
0.0071745026,
0.0034630247,
-0.010707298,
-0.021482665,
-0.006861384,
-0.025675735,
0.038772263,
-0.015056926,
0.009890467,
-0.010067447,
0.008365715,
-0.030631177,
-0.016745044,
0.00806621,
0.013654699,
0.014743807,
0.023524744,
-0.012116333,
0.0059866933,
-0.0034221832,
0.015206678,
-0.0013715961,
-0.0117896,
-0.015519797,
-0.0018191516,
0.03702969,
0.008923884,
-0.015124995,
-0.027418308,
0.03561385,
0.000023691302,
0.011306308,
0.034089096,
-0.015233906,
-0.0015102873,
-0.018188113,
-0.00114952,
-0.0034221832,
0.016676975,
0.0021441823,
0.0031022576,
-0.019985141,
0.018977717,
-0.013116951,
0.017752469,
-0.02590717,
0.010319304,
0.010067447,
0.009475244,
-0.0058267307,
-0.011912124,
0.02291212,
-0.026492566,
0.0050507407,
0.020039598,
-0.00623855,
-0.015547024,
-0.002870822,
-0.013620663,
-0.018188113,
-0.0069158394,
-0.009938115,
-0.012150367,
-0.015383658,
-0.0139405895,
-0.0119665805,
0.006943067,
0.020883657,
-0.011741951,
-0.009740715,
0.0026223692,
-0.012456679,
-0.022571774,
0.015982667,
-0.0002305847,
-0.007140468,
-0.0010261445,
0.006296409,
-0.009645417,
-0.02054331,
0.01797029,
0.004097771,
-0.012735763,
-0.007603339,
0.00036565968,
-0.014975242,
-0.018474003,
-0.0076305666,
-0.0043428205,
-0.0020097457,
-0.011415219,
0.18612865,
-0.029868802,
-0.009856433,
0.022844052,
-0.015288361,
-0.008787745,
-0.021945538,
-0.00842017,
0.0055102087,
-0.0008049193,
0.032128703,
0.008780938,
0.007324255,
0.003958229,
0.015941827,
-0.0044347136,
-0.028289594,
-0.02619306,
-0.033898503,
-0.011374378,
0.015492569,
-0.001460937,
0.0010959154,
-0.004022895,
0.026111377,
0.007964106,
-0.029269792,
0.021700488,
0.0148527175,
-0.017915836,
-0.034851473,
0.0034255867,
-0.0013886134,
-0.0015655935,
0.0001235883,
0.013995045,
-0.037438106,
-0.038881175,
0.006466582,
-0.0013928678,
-0.019209152,
0.00060836924,
-0.007405938,
0.020951726,
-0.014689351,
0.03918068,
-0.006738859,
-0.005299194,
0.0021203582,
-0.012313734,
-0.032673255,
-0.0021901291,
0.013892941,
0.009958536,
-0.0079913335,
-0.014335391,
0.022326725,
-0.007120047,
-0.0031924495,
0.022435635,
-0.027581673,
-0.0016421715,
-0.031094048,
0.048356418,
0.00744678,
0.046967804,
-0.021877468,
0.0081547005,
-0.004186261,
-0.014961628,
0.00786881,
0.00001559478,
-0.025117565,
-0.024831675,
-0.004162437,
-0.010380566,
0.019726478,
0.022326725,
0.014771035,
-0.0069260495,
0.005513612,
-0.010251234,
0.0054659634,
0.01092512,
-0.0072902204,
-0.026941823,
0.025049496,
0.0037880556,
-0.026805684,
0.011599006,
0.0047580427,
0.0089102695,
-0.018297024,
0.003798266,
0.0047682533,
-0.01447153,
0.006708228,
-0.0004586168,
0.008726482,
-0.032210384,
-0.018147271,
0.06311384,
0.011299501,
-0.009114477,
-0.006718438,
-0.005013303,
-0.005112003,
0.0007993886,
-0.0014252006,
-0.033871274,
-0.0079981405,
-0.023905933,
-0.00042713474,
0.0117896,
-0.0035838478,
0.01708539,
0.014757421,
-0.00040139607,
0.012150367,
0.0036485137,
-0.0089102695,
-0.012177595,
0.0068103317,
0.026002467,
-0.008869427,
-0.0029967502,
-0.045905925,
0.010870664,
-0.008032176,
-0.042311866,
-0.00083427416,
-0.005288983,
0.0033456052,
0.039398503,
-0.0042781546,
0.00096573296,
0.0056769783,
-0.020175736,
-0.028289594,
-0.0017383193,
-0.0117964065,
-0.0073446757,
0.011353957,
-0.012640466,
-0.0006058166,
-0.00503032,
0.02481806,
0.021972764,
-0.018106429,
-0.0074535864,
-0.005969676,
-0.04536137,
-0.022816824,
-0.024722764,
0.021591578,
-0.0045334143,
-0.008011755,
-0.006830753,
-0.0127221495,
0.024273507,
-0.013219055,
0.022136131,
0.008100245,
-0.007106433,
-0.004002474,
-0.0147029655,
-0.17142569,
0.0070928195,
0.00020388878,
-0.0136342775,
0.03014108,
0.020951726,
-0.007405938,
-0.013021654,
-0.036022265,
0.024232665,
0.030876227,
0.0104350215,
-0.04977226,
0.008474626,
0.0037574244,
-0.0013843591,
-0.01697648,
0.02347029,
0.020924497,
0.015193064,
0.046858896,
-0.015029698,
-0.0011520727,
-0.0060819904,
-0.0018021343,
0.046014834,
-0.00848824,
-0.0017221529,
-0.0093731405,
-0.032128703,
-0.026451724,
-0.00041990238,
0.016785886,
-0.0067218416,
0.025757417,
-0.0031465027,
0.0030563108,
-0.02594801,
-0.0108978925,
0.03024999,
0.03370791,
0.010870664,
0.011782793,
-0.018936874,
-0.02012128,
0.030059395,
0.0062793912,
-0.0151522225,
0.0222042,
-0.017344054,
0.021115093,
-0.022190586,
0.023538359,
0.014743807,
0.022993805,
0.009413982,
-0.007065592,
0.0037267932,
-0.01143564,
0.003189046,
-0.0016506801,
-0.027404694,
0.02524009,
-0.0025423877,
0.004472152,
-0.039643552,
0.004056929,
0.01673143,
-0.009155319,
0.0026768246,
-0.009543314,
-0.007065592,
0.015383658,
-0.031747513,
0.007773512,
0.02661509,
0.0012048263,
0.009747521,
0.019467816,
-0.01673143,
-0.006840963,
0.018501231,
-0.027132416,
-0.015383658,
-0.02424628,
0.0005347693,
-0.011163362,
0.008590343,
0.008706061,
-0.0038969666,
-0.0024641082,
-0.022925735,
-0.013266703,
-0.027704198,
0.030386128,
0.03215593,
-0.0156150935,
-0.028507415,
-0.016159648,
0.0053264215,
-0.0027006487,
-0.027527219,
-0.021373754,
0.01609158,
0.017670786,
-0.014376232,
-0.011599006,
-0.00036544696,
0.026628705,
-0.00018527608,
0.008726482,
-0.002084622,
0.025457913,
0.013443683,
-0.004696781,
0.0072629927,
-0.01230012,
-0.0051392308,
0.0014592353,
-0.025920784,
0.07013859,
-0.00025036733,
-0.0154653415,
0.017099004,
-0.011503709,
-0.012694921,
-0.14103955,
-0.033517316,
0.0047750603,
-0.0005951808,
-0.020597765,
0.015301975,
-0.020638607,
-0.001270343,
-0.0066605792,
0.012844674,
-0.009332299,
-0.016472766,
-0.001982518,
-0.005241335,
-0.005404701,
0.0098223975,
0.017779697,
0.00988366,
-0.011912124,
0.020448012,
0.0016566362,
-0.0029865399,
0.0067865076,
0.0022462863,
0.016323015,
-0.02453217,
-0.019195538,
0.03991583,
0.018896034,
0.0272141,
0.009005566,
-0.006143253,
0.015165837,
0.0011554761,
-0.025743803,
0.01161262,
0.004689974,
-0.014757421,
0.035749987,
-0.0018685019,
0.00007253633,
0.016758658,
-0.006231743,
-0.0033932538,
0.020951726,
-0.01170111,
-0.017834153,
0.008141086,
0.027309397,
-0.0181745,
-0.03395296,
-0.043754935,
-0.04669553,
-0.013573015,
0.018909646,
-0.027445536,
0.0050167064,
0.03896286,
-0.008032176,
-0.005792696,
0.033054445,
-0.016581677,
0.008161508,
-0.009570541,
0.01832425,
-0.031720288,
-0.023633655,
-0.01983539,
0.029133653,
-0.045551963,
0.013654699,
-0.011980194,
-0.023933161,
-0.004713798,
-0.025444299,
0.0057008024,
-0.0032809395,
-0.0005096688,
0.021278458,
0.0026853331,
-0.028970288,
-0.006109218,
0.015424499,
-0.013641085,
0.04487127,
0.012340961,
0.005071162,
0.002928681,
0.008876234,
0.00096658384,
-0.008011755,
0.033789594,
-0.0036417067,
-0.0019620971,
-0.018351479,
0.04217573,
0.0061534634,
-0.011408412,
0.018841578,
0.03248266,
-0.0140903415,
0.005054144,
-0.06295048,
0.016608905,
-0.017738855,
0.001556234,
0.003512375,
-0.010407793,
0.0025100547,
-0.014212866,
0.016581677,
0.027254941,
-0.01163304,
0.0006296409,
-0.025689349,
0.0119665805,
-0.027935633,
-0.006585703,
0.020325487,
-0.011741951,
0.019304449,
0.02954207,
-0.009522893,
-0.002972926,
0.0009138301,
0.010339724,
-0.012892323,
0.019726478,
-0.008801359,
0.04261137,
0.00667079,
0.009407175,
0.01564232,
-0.017235143,
-0.017602718,
0.0031175732,
-0.019644795,
-0.013103337,
-0.0007189818,
0.023184398,
0.011374378,
0.011864476,
-0.00997215,
-0.03738365,
0.003061416,
-0.008004948,
-0.017820539,
0.005704206,
-0.029596524,
0.009155319,
-0.0059662727,
-0.01832425,
0.014784648,
0.0022888298,
-0.012374996,
-0.03656682,
-0.0181745,
0.009339105,
0.01792945,
0.0018242568,
-0.013545788,
-0.00273128,
0.0056769783,
0.005316211,
0.02739108,
0.009482051,
0.0036723379,
-0.038990084,
-0.02541707,
0.0148527175,
-0.012803832,
-0.03155692,
-0.012225243,
0.015329203,
0.0013222458,
-0.021224003,
-0.0038595283,
0.006626545,
-0.0028895412,
-0.0034340953,
-0.002052289,
0.028970288,
-0.005799503,
-0.01927722,
-0.017153459,
-0.009951729,
0.034361374,
-0.005809713,
-0.00016698246,
0.018664598,
-0.0012618344,
0.0024998444,
-0.0088422,
0.015819302,
0.02227227,
0.013722768,
0.026724001,
0.025539596,
-0.0032435013,
-0.0016481276,
0.010040219,
0.026315585,
0.013852099,
-0.02262623,
0.0072493786,
-0.010741333,
0.004696781,
0.020747518,
-0.021646032,
-0.036730185,
-0.019073013,
0.0052753696,
0.0066333516,
0.022054449,
-0.0071608885,
0.008052596,
-0.03515098,
-0.005857362,
0.024586625,
0.0070792055,
-0.023660883,
0.0381188,
0.008855814,
0.023361377,
-0.0050405306,
-0.004427907,
0.014975242,
-0.0017315124,
0.03321781,
-0.0371386,
0.023007417,
-0.0043870653,
0.010101481,
0.012572397,
-0.037410878,
-0.013293931,
0.010271655,
-0.0046933773,
0.026233902,
0.023238853,
-0.016009895,
0.08957918,
0.011292694,
-0.008937497,
-0.005394491,
-0.031883653,
0.012320541,
0.030658405,
0.013852099,
0.017629944,
-0.02668316,
0.012817446,
-0.007412745,
0.032945532,
-0.03547771,
-0.042339094,
0.020039598,
-0.0051392308,
-0.0075761112,
0.0066333516,
-0.020693062,
0.0022701106,
0.010006185,
0.020761132,
0.014199252,
-0.025430685,
-0.010067447,
0.0025457912,
-0.016159648,
0.009659031,
-0.02714603,
0.023334151,
-0.005976483,
-0.03177474,
-0.027323011,
0.013797644,
-0.022884894,
-0.004574256,
-0.009836012,
0.013123758,
0.0014881648,
-0.015301975,
0.018501231,
-0.031202959,
-0.012987619,
-0.0015290063,
-0.013926975,
-0.0358589,
-0.011449253,
-0.0032605187
] |
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with complicated genetic inheritance. Programmed death 1 (PD-1), a negative T cell regulator to maintain peripheral tolerance, induces negative signals to T cells during interaction with its ligands and is therefore a candidate gene in the development of SLE. In order to examine whether expression levels of PD-1 contribute to the pathogenesis of SLE, 30 patients with SLE and 30 controls were recruited and their PD-1 expression levels in peripheral blood mononuclear cells (PBMCs) were measured via flow cytometry and quantitative real
|
[
-0.021761598,
0.019710355,
-0.0012047773,
-0.02187994,
-0.033845533,
0.028664825,
-0.020880615,
0.007100461,
-0.04560074,
-0.017606514,
0.0037376038,
0.0040433183,
0.021156745,
0.02202458,
-0.0069229496,
0.002610077,
0.035265625,
-0.013990538,
0.005548879,
0.0003710484,
-0.021459172,
-0.019092351,
0.004957174,
-0.004658034,
-0.0018540093,
0.0088953,
0.01337911,
-0.05057106,
-0.018211368,
-0.0031672658,
0.0146085415,
-0.01832971,
-0.015989186,
0.008553426,
0.011676314,
-0.011551399,
-0.0009360446,
0.0023142244,
0.013339663,
0.0018326421,
0.016659785,
0.021143595,
-0.0023881875,
-0.022090323,
-0.015713058,
-0.010723012,
-0.0019970047,
-0.007494931,
-0.007705315,
0.020131122,
0.01976295,
-0.002084117,
-0.0032379418,
-0.010565223,
-0.017856345,
-0.015095054,
0.00083085254,
0.018474348,
0.01383275,
-0.023799693,
0.0018819509,
-0.0061372966,
-0.026192812,
0.009789432,
0.008829555,
-0.006403564,
0.0059400615,
0.02569315,
0.016317911,
-0.007915699,
0.038921047,
0.021327682,
-0.016291613,
-0.0019953612,
-0.0005234947,
-0.020499295,
-0.01172891,
0.0043260218,
-0.012820277,
0.00025311828,
0.014082582,
-0.02819146,
-0.013556621,
0.002381613,
0.013385684,
-0.008809831,
-0.011709186,
0.007494931,
0.004227404,
-0.009697389,
0.006837481,
0.01061782,
0.00019959774,
0.013392258,
-0.02161696,
0.018211368,
0.03834249,
0.014371859,
-0.011255546,
-0.028927805,
-0.009960369,
0.009092535,
-0.0033858682,
-0.016186422,
-0.039999265,
-0.0021876653,
-0.004855269,
0.0026150078,
0.010039263,
0.0030670047,
-0.03229395,
0.037974317,
0.00268404,
-0.02266888,
0.02452289,
-0.015713058,
0.0014135177,
-0.013582919,
-0.018487496,
-0.00134202,
0.018737327,
0.002697189,
0.028270354,
-0.023510415,
0.032057267,
0.0068572047,
-0.020998957,
-0.0031343934,
-0.001056851,
0.015713058,
-0.0049768975,
0.025364425,
-0.0069689713,
-0.0066172355,
-0.0035633796,
-0.01949997,
-0.0069098007,
0.0029355148,
-0.014542797,
-0.03387183,
0.021682704,
0.044575118,
-0.026061323,
-0.002084117,
0.03334587,
0.01831656,
0.0151082035,
-0.0021646544,
-0.018250816,
-0.010782181,
-0.014937267,
-0.017895792,
-0.015713058,
-0.025772044,
-0.010729586,
0.0028040246,
0.0042569893,
0.02887521,
-0.015265992,
-0.020630784,
-0.0043753306,
-0.010302243,
-0.008421936,
0.015976038,
-0.002999616,
0.03650163,
-0.0023799695,
0.011479079,
0.0000882935,
0.0057329647,
-0.026363749,
0.017343534,
-0.017448725,
0.011899847,
-0.006058403,
0.0007470277,
-0.023786545,
-0.0051741325,
-0.018947711,
-0.0046514594,
0.007041291,
0.04047263,
0.01232719,
0.013661813,
-0.01581825,
-0.0040860525,
0.021248788,
-0.016304763,
0.0003420795,
-0.013135853,
0.0016156837,
0.015239693,
0.0055718897,
-0.05648811,
-0.6298898,
-0.027849587,
0.037316866,
0.0076198466,
-0.008704639,
0.043181323,
0.023076499,
-0.003645561,
-0.035239324,
0.01488467,
-0.0077316132,
0.026390048,
-0.00008526306,
-0.0113607375,
-0.0025952843,
-0.027981076,
-0.006337819,
-0.01989444,
0.021104148,
-0.006636959,
-0.0018983872,
0.0061340095,
0.005361506,
0.008040614,
0.006308234,
-0.002736636,
0.017501323,
-0.017409278,
0.0021021967,
0.029743044,
-0.015173948,
0.019263288,
-0.0008230453,
-0.00863232,
0.047441598,
-0.0028845624,
0.005525868,
0.024483442,
0.028717421,
0.04665266,
-0.018250816,
0.015634164,
0.0055324426,
-0.008803257,
0.003219862,
0.023076499,
-0.004963748,
0.011170077,
0.015384332,
-0.009966943,
0.030137513,
0.012899171,
-0.017067404,
0.0026955453,
0.009539601,
0.01383275,
0.029611552,
-0.0084022125,
0.0015647312,
-0.0035896776,
0.0055784644,
0.01370126,
-0.0056244857,
-0.007646145,
0.0017784025,
-0.00039323734,
-0.014818925,
0.0040104454,
-0.014292966,
0.009730262,
0.010440308,
0.022655731,
0.0044049155,
0.011472505,
0.016186422,
0.015489524,
0.013648665,
0.016528295,
-0.01831656,
0.005604762,
-0.011341014,
-0.0047467896,
-0.013385684,
-0.001750461,
0.0184612,
-0.0040992014,
-0.003750753,
0.03936811,
-0.009605346,
0.0135040255,
0.014779478,
-0.0055324426,
-0.015726207,
-0.033030294,
-0.01790894,
0.027823288,
-0.0034286024,
0.00615702,
0.0007729148,
-0.02134083,
-0.0129320435,
-0.016120676,
0.0016830723,
-0.002329017,
0.03942071,
0.016488848,
-0.05443687,
-0.012603318,
0.043181323,
-0.01700166,
0.0015778802,
-0.012103656,
-0.015923442,
-0.016160123,
-0.01093997,
-0.0080800615,
0.001947696,
-0.003136037,
0.015765654,
-0.02002593,
0.015305438,
-0.0009639862,
0.006916375,
-0.005548879,
-0.0055817515,
0.011906422,
-0.008704639,
-0.011498802,
0.024220461,
-0.01409573,
-0.016239017,
-0.0146085415,
0.020657083,
-0.019578865,
0.018119326,
-0.029532658,
0.026955454,
0.007534378,
0.011630292,
-0.023891738,
-0.009631644,
-0.015976038,
0.005052504,
0.012577021,
0.0056474963,
-0.005325346,
-0.012340339,
-0.0066796932,
0.015239693,
0.0092306,
0.011301568,
-0.003964424,
0.0023487406,
0.027849587,
-0.0014858373,
-0.0069360984,
-0.014174624,
-0.017277788,
-0.020775422,
-0.007455484,
0.013221322,
-0.001750461,
-0.019592013,
0.0073634414,
-0.021787897,
-0.007849954,
0.0045890016,
0.027560309,
-0.01238636,
-0.027612904,
-0.0015647312,
0.0074291863,
-0.018934563,
0.0040893396,
0.0039677112,
-0.016462551,
0.0003003725,
-0.026797667,
0.0005900615,
0.0069229496,
-0.010775607,
-0.0009352228,
0.012800554,
0.009605346,
0.025535362,
0.01310298,
0.02239275,
0.014989862,
0.011650016,
0.03213616,
0.0016682796,
0.020788573,
-0.038421385,
0.017974686,
-0.008875577,
0.003961137,
-0.0062917974,
0.010834778,
0.021156745,
0.021248788,
-0.010644117,
-0.034608174,
-0.005266175,
-0.013543473,
0.01099914,
-0.04465401,
0.001495699,
-0.029480062,
0.01948682,
0.012445531,
-0.008494255,
0.011735484,
0.016843872,
-0.016041782,
-0.0038362213,
0.025916683,
0.023207989,
-0.017422428,
0.004260277,
-0.0012466898,
-0.012563871,
0.01579195,
0.026626728,
-0.04047263,
-0.0051379725,
0.005456836,
0.03492375,
0.016028633,
0.0045495545,
-0.023102798,
-0.025377573,
-0.0045824274,
0.007632996,
0.012090508,
-0.007988019,
0.011117482,
0.014398158,
-0.008224701,
0.031846885,
-0.0044509373,
-0.009237174,
0.0029815363,
0.00030550885,
-0.0009787788,
0.0017652535,
-0.0057888483,
0.014385008,
-0.0113607375,
-0.01529229,
0.019605162,
-0.017290939,
0.016843872,
-0.025351277,
0.01013788,
-0.003987435,
-0.0013222966,
0.0037639018,
-0.00322808,
0.033687744,
0.015305438,
0.033240676,
-0.0135040255,
0.0037901998,
-0.01764596,
-0.0066731186,
-0.021801045,
0.0016682796,
-0.027349925,
0.01606808,
-0.013142427,
-0.034187406,
-0.0054929955,
0.007231951,
-0.04362839,
0.008112934,
0.021104148,
0.022327006,
0.021248788,
0.03463447,
0.0059104767,
-0.010275945,
-0.018027281,
0.027376223,
0.028770017,
-0.011294993,
-0.026508389,
-0.020854317,
-0.02120934,
0.0061997543,
0.009013641,
0.021511767,
0.019618312,
0.0016337635,
0.027507713,
-0.016633488,
0.0018622275,
0.019815546,
-0.0058282954,
0.0135040255,
-0.0151082035,
-0.0071596317,
0.0012401153,
0.0022731337,
-0.032478034,
0.03284621,
0.013260769,
-0.01132129,
-0.006640246,
-0.006101137,
-0.005706667,
0.016304763,
-0.021971982,
-0.0016025347,
-0.016317911,
0.0073305685,
0.00146447,
0.0026199387,
0.01501616,
0.029453766,
-0.0086520435,
-0.01844805,
-0.02979564,
0.008691491,
-0.01777745,
0.031715393,
0.02792848,
-0.0036850078,
0.019092351,
-0.008421936,
0.021564363,
-0.019184394,
-0.025075147,
0.03805321,
0.00047007683,
-0.023273734,
0.0037803382,
-0.009723687,
0.013622366,
0.020538742,
0.030190108,
0.022616284,
-0.026153365,
0.00016867704,
0.020867467,
0.0057362523,
-0.002223825,
0.022589985,
0.02753401,
0.017356683,
-0.021446023,
0.0066205226,
-0.003180415,
0.0022599848,
-0.021117298,
-0.013977389,
0.03942071,
-0.0032741015,
0.01370126,
-0.029690446,
-0.0054371124,
0.010834778,
0.017067404,
0.005460123,
-0.0051774196,
0.030216407,
0.012208848,
0.015542121,
0.005575177,
-0.0003346832,
-0.017225193,
0.0032872506,
0.008277297,
0.014700584,
-0.027323626,
0.022760922,
-0.021630108,
-0.020841168,
-0.019013457,
0.016659785,
0.0010913672,
-0.005101813,
-0.01949997,
-0.009934071,
0.003569954,
-0.006949248,
-0.016160123,
-0.0070281415,
-0.00902679,
-0.019013457,
0.0035863903,
0.011965592,
0.0011390323,
-0.024325654,
-0.013977389,
0.007836806,
-0.023918035,
-0.018487496,
0.015726207,
0.02437825,
-0.0031393243,
0.014200922,
-0.016146975,
0.017895792,
0.027823288,
0.0034877728,
-0.0068835025,
0.010012965,
-0.027875885,
0.01949997,
0.015173948,
0.018408602,
-0.0141088795,
-0.008461383,
0.005995945,
0.0026117205,
-0.020893764,
0.020854317,
0.010525776,
-0.018605838,
0.0023536715,
0.033661444,
0.0289804,
-0.010144455,
0.00014412538,
-0.009250323,
-0.023668204,
-0.037001293,
-0.017987834,
-0.003214931,
-0.04149825,
0.012379785,
0.006051828,
0.004224117,
-0.014056283,
-0.01593659,
-0.007836806,
0.0022073886,
-0.00048856763,
0.016488848,
0.02385229,
-0.009796007,
0.0010428802,
0.023089647,
-0.018290263,
-0.012261445,
-0.025009401,
0.03600197,
-0.0037901998,
-0.013339663,
-0.009467281,
0.004911152,
-0.032451738,
-0.0002995507,
-0.02014427,
-0.009493579,
0.029032996,
0.011794655,
-0.007534378,
-0.03305659,
0.011064885,
-0.003025914,
-0.0032888942,
0.020565039,
-0.010203626,
0.0009639862,
0.0034549003,
-0.0024966667,
-0.007948572,
0.034345195,
-0.030479386,
-0.008796683,
0.0052365903,
-0.012103656,
0.021695854,
-0.010032688,
0.0008637251,
-0.0019970047,
0.0130372355,
0.012491552,
-0.045784824,
-0.007955146,
-0.0025772045,
0.04944025,
0.039736286,
0.027823288,
-0.0138590485,
0.021630108,
0.010716436,
0.0005855415,
0.010065561,
-0.01270851,
0.009710538,
-0.009243748,
0.011544824,
0.0021778035,
-0.0067388634,
0.03468707,
-0.031084241,
0.02450974,
0.024983104,
-0.00994722,
-0.022077175,
0.0038822428,
-0.036054563,
-0.02661358,
0.0369224,
-0.0124323815,
0.027875885,
-0.033924427,
-0.0042997235,
-0.0034614748,
0.0073174196,
0.00292894,
-0.0034187406,
0.021130446,
-0.018513795,
0.039236624,
-0.009789432,
0.003201782,
0.005144547,
-0.021643257,
0.0007909947,
0.008724363,
0.01396424,
0.011866975,
0.022774072,
0.015489524,
-0.003104808,
0.010854501,
0.0074291863,
-0.026153365,
-0.029690446,
-0.023037052,
-0.019697206,
-0.008586299,
-0.0012261445,
-0.02134083,
-0.029953428,
-0.0017323811,
0.005650784,
-0.010394286,
0.01673868,
-0.041340463,
-0.034502983,
0.014700584,
-0.012412658,
0.008842704,
-0.013517174,
0.010170753,
0.038000617,
-0.004766513,
-0.018369157,
0.008224701,
0.0046646083,
0.0038000615,
0.023418372,
0.013273918,
-0.024404548,
-0.007494931,
0.0039019664,
0.0022616284,
-0.00546341,
-0.026823964,
0.008553426,
-0.013300216,
-0.008849278,
-0.0127545325,
-0.016515147,
0.003425315,
-0.0077118897,
-0.019539418,
0.0109333955,
-0.007863103,
-0.004947312,
-0.004516682,
0.0020117974,
-0.024036376,
0.005266175,
-0.006955822,
-0.03623865,
-0.0068769283,
-0.024720125,
0.0052398774,
-0.009250323,
0.0018885254,
0.039394412,
0.015371184,
0.0052037174,
-0.005325346,
-0.021419724,
0.038000617,
-0.001289424,
-0.019079203,
0.044838097,
-0.0016912904,
0.0056803687,
0.013714409,
-0.006650108,
-0.0058414442,
-0.0028796315,
-0.012373211,
-0.013872197,
-0.0289804,
-0.011216098,
0.019394778,
0.008724363,
-0.012879448,
0.011380461,
-0.033030294,
-0.02174845,
0.0006258103,
-0.012767681,
0.015870845,
-0.03915773,
0.015778802,
-0.0019279724,
-0.0027086944,
0.010486329,
0.025193488,
-0.006903226,
-0.007876252,
0.026981752,
-0.019158097,
0.029217083,
0.009066237,
0.0027399233,
-0.009210876,
0.020328358,
-0.03623865,
-0.029453766,
0.01343828,
0.019684056,
-0.02963785,
-0.027902182,
-0.008612596,
0.005719816,
0.013444855,
-0.014674286,
0.027718097,
-0.0049900464,
0.024785869,
-0.002263272,
-0.0025887098,
0.01856639,
-0.017948387,
-0.014950415,
0.029532658,
0.00023134025,
-0.0061077117,
0.0043786177,
0.0144902,
0.011807804,
-0.0041517974,
-0.008730938,
-0.023405224,
0.0019937174,
0.0069229496,
0.012412658,
-0.019776098,
0.0121825505,
-0.008849278,
0.00882298,
0.016672935,
-0.014700584,
-0.00915828,
-0.00015819893,
-0.016541444,
-0.002013441,
-0.004963748,
0.006180031,
-0.009118833,
-0.037001293,
-0.02266888,
0.004894716,
-0.036133457,
0.051859666,
0.021958834,
0.01634421,
-0.019092351,
0.014779478,
-0.05125481,
-0.011735484,
0.016028633,
0.0055718897,
0.006166882,
0.02924338,
-0.0127874045,
0.011452781,
0.00934894,
0.021932535,
-0.005170845,
-0.05072885,
-0.0017159447,
-0.0108282035,
0.018145623,
0.006087988,
-0.017738003,
-0.019973334,
0.015528971,
-0.004697481,
-0.016239017,
0.006705991,
-0.021406576,
0.034161106,
0.0100063905,
0.009368664,
-0.01396424,
-0.0026856838,
0.01132129,
-0.012300892,
0.016528295,
-0.005114962,
-0.0105455,
-0.017185746,
-0.009375239,
0.027376223,
0.0033184795,
-0.013458003,
-0.012031337,
-0.020472996,
-0.015489524,
-0.0075606764,
0.021774748,
0.012228572,
-0.025627404,
0.031005347,
-0.017330384,
0.007396314,
-0.020801721,
-0.017948387,
0.017830048,
-0.0006237558,
-0.003908541,
0.012484978,
-0.0055718897,
0.022524241,
0.009059663,
-0.018789925,
-0.0110780345,
-0.016567742,
0.0032165747,
-0.042366084,
0.01777745,
0.008211552,
0.0009804225,
0.010492904,
-0.020775422,
-0.032215055,
-0.008375915,
0.0037080187,
0.026784517,
-0.019986482,
-0.007823656,
-0.011873549,
-0.0035995394,
-0.018658433,
-0.0055455915,
-0.009822304,
-0.028954104,
0.01844805,
0.20870095,
-0.013142427,
0.0013083257,
-0.0023191553,
-0.0014110523,
-0.0011719048,
0.009171429,
0.0008900231,
-0.007192504,
0.01212338,
0.020998957,
-0.03174169,
-0.010703288,
0.007238526,
0.0047172047,
-0.02541702,
-0.03068977,
-0.013431706,
-0.007751337,
-0.02123564,
0.011091183,
0.0014578956,
0.0032856069,
-0.005049217,
0.024588633,
0.01609438,
-0.00011895738,
-0.00019394778,
0.019578865,
-0.0047402154,
-0.032004673,
0.030663474,
0.016239017,
-0.010887374,
-0.010170753,
-0.0020430263,
-0.017724855,
-0.016265316,
0.014029985,
-0.00071990787,
-0.014647989,
-0.018921414,
-0.01856639,
-0.025403872,
0.007922274,
0.0050820895,
-0.010177327,
-0.014398158,
-0.0076790173,
0.006058403,
-0.024023227,
-0.0059499233,
0.00883613,
0.02465438,
0.011834102,
0.018369157,
0.019815546,
0.032714717,
-0.0073239943,
-0.00023914747,
0.0018211368,
0.0035469434,
-0.038211,
0.015581568,
0.006758587,
0.014713733,
-0.014963564,
0.0002079186,
0.009769709,
-0.027113242,
-0.004957174,
-0.02161696,
0.011669739,
-0.00750808,
0.002184378,
-0.009362089,
0.025627404,
0.021722151,
0.01672553,
0.018211368,
-0.0042569893,
-0.007238526,
-0.033740338,
0.010657266,
0.0066829803,
-0.032925103,
0.021840492,
-0.007455484,
-0.03571269,
-0.0038395086,
0.0017866207,
-0.004066329,
-0.010072135,
-0.0058315825,
0.01856639,
-0.019736651,
0.02264258,
0.005016344,
-0.009408111,
-0.039184026,
-0.011656591,
0.08457438,
0.008947896,
0.022839816,
-0.001737312,
0.013845899,
0.00021901306,
-0.0038033489,
0.011952443,
-0.0022731337,
0.01450335,
-0.029269679,
0.0137538565,
-0.005312197,
-0.023207989,
0.029927129,
-0.009105684,
-0.007738188,
0.0010593164,
-0.002605146,
0.0039052537,
-0.015555269,
-0.015397482,
0.02529868,
-0.0042306916,
0.0053483564,
-0.026219111,
0.0051872814,
-0.0024621508,
-0.020486146,
-0.0028319664,
0.0008004455,
-0.010367989,
0.019197542,
0.020407252,
-0.010749309,
-0.006482458,
0.011235822,
-0.015528971,
0.0057395394,
-0.013661813,
0.0059893704,
-0.015318587,
0.004030169,
0.014595392,
-0.011071459,
0.012484978,
0.013767005,
-0.030084917,
0.0052300156,
-0.01356977,
-0.019618312,
-0.014516498,
-0.015699908,
0.02490421,
-0.010479755,
-0.017501323,
0.003556805,
-0.002184378,
-0.000535,
-0.032583226,
0.030374195,
-0.007988019,
-0.006022243,
-0.012057635,
0.00066073734,
-0.16462551,
-0.0027908757,
0.0031968511,
-0.020052228,
0.004713917,
0.024983104,
-0.0032839633,
0.01700166,
-0.00035153035,
0.0148583725,
0.033398464,
-0.005259601,
-0.011426483,
-0.0058973273,
-0.004000584,
0.015528971,
-0.015265992,
0.053832013,
0.026639879,
0.011761783,
0.029059295,
-0.00974341,
-0.015121353,
-0.028901506,
0.011373887,
0.007199079,
0.03279361,
-0.003740891,
-0.0072451,
-0.007139908,
-0.033188082,
0.008770385,
0.03387183,
0.009894624,
0.012695362,
-0.008356191,
0.0011127343,
-0.0113278655,
-0.0066764057,
0.028138865,
0.03279361,
0.0017570354,
0.013543473,
0.0082575735,
-0.009164855,
0.03926292,
0.008454808,
-0.0067224274,
0.023957482,
-0.006245776,
0.008921598,
-0.0062917974,
0.015147651,
0.013819601,
0.031820584,
0.004174808,
0.019697206,
0.017461875,
-0.00850083,
0.016449401,
-0.0026708911,
-0.02713954,
0.019289587,
0.016002337,
0.01938163,
-0.021051552,
-0.0043227347,
0.025785193,
-0.012715085,
0.023996929,
-0.01099914,
-0.0137538565,
0.017711706,
-0.008020891,
0.030269003,
0.0016633488,
-0.01212338,
0.020341506,
0.006140584,
-0.032109864,
0.0005847197,
-0.0034976345,
0.0054765595,
-0.016672935,
-0.013885346,
-0.00073757686,
0.016054932,
0.013333088,
0.013911644,
-0.02343152,
0.0014159832,
-0.023904886,
0.0064331493,
-0.007817082,
0.0051281108,
0.017685408,
-0.025390724,
-0.01298464,
-0.011866975,
0.017382981,
0.009059663,
-0.03124203,
-0.022760922,
-0.02027576,
0.019158097,
-0.027192136,
-0.009487005,
-0.0013600999,
0.026166514,
-0.01171576,
-0.013083257,
0.018224517,
0.003816498,
0.029427467,
-0.0052267285,
0.010216774,
0.02278722,
0.007856529,
-0.0077579115,
-0.040761907,
0.079893336,
0.014253519,
0.006811183,
0.045416653,
0.015476376,
-0.019592013,
-0.12055005,
-0.021051552,
0.019092351,
-0.0028434717,
-0.012879448,
0.028664825,
-0.0036652843,
0.034660768,
-0.033582553,
0.013727558,
-0.0005522581,
-0.0052924734,
-0.0063739787,
-0.025982428,
0.012208848,
0.0039578495,
0.010959693,
-0.015384332,
-0.028428143,
0.03665942,
0.0009138556,
0.0013650308,
0.016107528,
-0.00895447,
0.0018326421,
-0.000041321768,
-0.03187318,
0.01489782,
0.00042117896,
0.024299355,
-0.006613948,
-0.00011495104,
0.004273426,
0.008875577,
0.00033653228,
0.0013132566,
-0.016633488,
-0.037869126,
0.04452252,
0.004487097,
-0.0031672658,
0.019263288,
0.000045251058,
0.0022271122,
-0.010269371,
-0.006916375,
-0.031399816,
0.0058710296,
0.035528604,
-0.020630784,
-0.015594716,
-0.054226484,
-0.031689096,
0.0030933027,
-0.013951091,
0.0027152689,
0.005509432,
0.022090323,
-0.017948387,
-0.010690139,
0.031978372,
-0.0041517974,
0.013273918,
-0.008421936,
-0.0031196007,
-0.014924117,
-0.013195024,
-0.031294625,
0.023247436,
-0.015528971,
-0.011288418,
-0.03663312,
-0.017567066,
-0.01041401,
-0.010558649,
0.0055455915,
-0.018868819,
-0.022629432,
0.009092535,
-0.026600432,
-0.023155393,
-0.0022616284,
0.021577513,
-0.023470968,
0.053569034,
0.0073042708,
0.009112258,
0.002973318,
-0.011373887,
-0.0070215673,
-0.0071727806,
0.03279361,
0.009013641,
-0.017435577,
-0.00064594473,
0.011965592,
-0.019407928,
-0.022839816,
0.009487005,
0.02450974,
-0.023747098,
-0.021866791,
-0.064903475,
0.000526371,
0.00095165905,
0.006745438,
0.019539418,
-0.011603994,
0.011617144,
-0.020394102,
0.02518034,
0.0055817515,
-0.01765911,
0.003970999,
0.0024325654,
0.0033234102,
-0.023142245,
-0.013990538,
0.030847559,
0.011347589,
0.015371184,
0.034765963,
-0.0051248237,
0.001153825,
0.009066237,
0.021919386,
0.013293641,
-0.018198218,
-0.01859269,
0.0071333335,
-0.0056803687,
-0.013234471,
0.0024309217,
-0.034161106,
-0.020459848,
0.012129954,
-0.014740031,
-0.026166514,
0.032109864,
0.03345106,
0.031399816,
0.017146299,
-0.014056283,
-0.049492843,
0.003740891,
-0.017409278,
-0.01818507,
-0.0047336407,
-0.033082888,
0.012189125,
0.010880799,
0.0014891245,
0.042497575,
0.009296345,
-0.0119327195,
-0.01422722,
-0.017461875,
0.014253519,
-0.009861751,
-0.015029309,
-0.015371184,
-0.011124056,
0.011387036,
0.012340339,
0.005917051,
-0.0045725657,
0.014542797,
-0.02648209,
-0.035896774,
0.012728234,
-0.009993241,
0.009539601,
-0.012767681,
0.015003012,
0.0044279266,
0.0006126613,
0.026324302,
-0.020012781,
-0.026797667,
-0.00606169,
-0.02808627,
0.009296345,
0.011143779,
-0.000596636,
-0.011656591,
0.0046383105,
0.03147871,
-0.0024457143,
-0.016554594,
0.032267652,
0.014411306,
0.0077710603,
-0.0130043635,
0.010959693,
-0.010453457,
0.038658068,
0.012734809,
0.019513119,
0.010946544,
0.002828679,
-0.0015376115,
0.030216407,
0.010749309,
0.0077250386,
0.0070675886,
-0.00810636,
-0.018526943,
0.020998957,
-0.047362704,
-0.029164487,
-0.015252843,
-0.01278083,
0.001798126,
0.0064265747,
-0.009454133,
0.0011530031,
-0.0065284795,
0.0004893894,
-0.0044936715,
0.0075212293,
-0.016054932,
0.014332413,
0.004671183,
0.007652719,
0.00056828343,
0.009447558,
-0.008849278,
-0.006127435,
0.0047007683,
-0.01871103,
0.028033672,
-0.012530999,
0.017067404,
-0.007961721,
-0.04191902,
-0.00009866888,
-0.016528295,
-0.013490876,
0.027849587,
0.028349249,
-0.0047862367,
0.08904504,
0.017317235,
-0.019026605,
0.013543473,
-0.0030982336,
0.002425991,
0.001144785,
0.009888049,
0.009283195,
-0.034055915,
0.0355549,
-0.014398158,
0.02212977,
-0.038658068,
-0.018040432,
0.032057267,
-0.01869788,
0.009250323,
-0.0034647621,
-0.008224701,
0.024365101,
0.014634839,
0.009493579,
-0.0071070357,
-0.030794963,
-0.015739355,
0.04323392,
0.0056737945,
0.008750661,
-0.03784283,
0.008625746,
-0.0077184644,
-0.028244056,
-0.017146299,
0.029059295,
-0.021906238,
0.00054321816,
-0.034476683,
-0.01370126,
-0.003645561,
-0.00024839287,
0.032583226,
-0.005101813,
-0.026981752,
0.0060419664,
-0.008421936,
-0.021051552,
-0.0030242705,
-0.022866115
] |
Podocalyxin is the major sialoprotein in the glycocalyx of glomerular podocytes. Here we report on its extraglomerular localization, using a monospecific antibody which was obtained by affinity purification of IgG on nitrocellulose transfers of glomerular podocalyxin. By indirect immunofluorescence, podocalyxin was found in the blood vessels of several organs (lung, heart, kidney, small intestine, brain, pancreas, aorta, the periportal blood vessels in liver, and the central arteries of follicles of the spleen, but not in
|
[
0.0012354215,
0.009117527,
0.004690806,
-0.013811634,
-0.0047766333,
0.029894397,
-0.031690173,
-0.011164184,
-0.016993854,
0.01831428,
0.033538766,
-0.011408462,
0.011164184,
0.023411116,
-0.029735945,
-0.018868856,
0.03087151,
-0.000057613808,
-0.01386445,
-0.0029263895,
-0.013065594,
0.010477563,
-0.006965236,
-0.0053774263,
-0.004753526,
0.020506183,
0.010160661,
-0.043441944,
-0.009916383,
-0.027623268,
-0.004311184,
-0.0015217885,
-0.030924326,
0.0060112295,
0.011474484,
0.005806564,
-0.0021687963,
0.004053701,
-0.0010035221,
-0.0038622397,
0.019700725,
0.004938385,
0.0038160249,
-0.017456003,
-0.007691469,
0.0116923535,
-0.013917267,
0.001582858,
-0.024652313,
0.019832766,
-0.004545559,
-0.0013410555,
0.013204238,
-0.00520247,
-0.01130943,
-0.022882946,
0.014973607,
0.0050671264,
0.0035717464,
-0.033908486,
-0.0035255316,
-0.0029924104,
-0.007684867,
-0.017429594,
-0.009348601,
0.010121048,
-0.01261665,
0.006371045,
-0.009203354,
-0.014036106,
0.028151436,
0.04317786,
-0.026117984,
-0.024242982,
0.043943707,
-0.022249142,
-0.021800198,
-0.0050440193,
-0.014815155,
0.011487688,
0.01672977,
-0.039322224,
-0.013917267,
0.034066934,
0.006255508,
0.012973164,
0.013587162,
0.020506183,
-0.012590242,
-0.004994503,
0.018459525,
0.038926095,
0.02124562,
0.009044903,
-0.01647889,
0.020004421,
0.015092445,
0.024625905,
-0.0051133414,
-0.02202467,
0.0008978882,
0.015396142,
-0.015118853,
-0.025946328,
-0.039242998,
-0.0055028666,
0.0125836395,
0.0040140883,
0.023899673,
0.007684867,
-0.017231531,
0.049991246,
0.0031690171,
-0.033750035,
0.018182237,
-0.014973607,
0.03192785,
-0.027755309,
0.0018981093,
-0.010853884,
-0.00018434355,
0.016610932,
0.03242961,
-0.013904063,
0.033697218,
0.018921673,
-0.005760349,
-0.022869742,
-0.022486819,
0.008866646,
-0.0052651903,
0.03034334,
0.00023478786,
0.0023998704,
0.0112434095,
-0.015924312,
-0.034066934,
0.009685309,
0.00066805194,
-0.031320453,
-0.005367523,
0.026025554,
-0.005984821,
0.015501776,
0.019014103,
0.039823983,
0.02557661,
0.01629403,
0.01585829,
0.027174324,
0.01835389,
-0.014207761,
-0.02965672,
-0.012240329,
-0.005146352,
-0.018050194,
-0.0032515437,
0.040985957,
-0.010147457,
0.006305024,
-0.025180483,
0.0014747484,
0.020400548,
-0.007493405,
0.013349486,
0.01941023,
0.0073217503,
0.0022513226,
-0.0014912537,
-0.007354761,
-0.021760585,
0.016267622,
-0.026184006,
0.023041395,
0.0050506215,
0.02314703,
0.025101257,
-0.004535656,
-0.030211298,
-0.026474498,
-0.010134253,
0.03121482,
-0.00063627923,
0.005859381,
-0.004832751,
-0.008840238,
0.03242961,
-0.031848624,
-0.00551277,
-0.03258806,
-0.008661981,
0.012748692,
0.012114889,
-0.04301941,
-0.6380288,
-0.04177821,
0.038107432,
-0.004869063,
0.01361357,
0.03121482,
0.0128081115,
-0.0035783486,
-0.014709522,
0.012623252,
-0.007427384,
0.022539634,
-0.025959533,
0.01888206,
0.002622692,
-0.024533475,
0.007361363,
-0.011533902,
0.025510589,
-0.01199605,
-0.01252422,
-0.009130731,
0.002439483,
0.031294044,
0.008655379,
0.0032746512,
0.025946328,
-0.010814271,
-0.014617092,
0.02411094,
-0.041857436,
0.017271144,
-0.00014792873,
-0.00086240185,
0.043785255,
-0.019212168,
-0.013824837,
0.0006325655,
0.020519387,
0.052790545,
-0.0044135167,
0.0017561638,
0.0042352597,
-0.010814271,
-0.021258824,
0.01812942,
0.022420797,
0.021826606,
-0.012359167,
-0.021971853,
0.005034116,
0.0046709995,
-0.033010595,
0.002233167,
0.0007068394,
0.0036377676,
0.026738582,
-0.013309873,
0.0084111,
0.008556346,
0.020242097,
0.029551085,
-0.0017842228,
-0.017746497,
0.009388214,
-0.01551498,
-0.031610947,
0.0052651903,
0.008127209,
0.012134695,
0.0132108405,
0.022407593,
0.01492079,
0.012385576,
0.009724922,
0.019951604,
0.011533902,
0.0088732485,
-0.014656705,
-0.007909339,
0.00017402774,
0.0042319587,
-0.0031772698,
0.023635587,
0.01348813,
0.00079885643,
-0.038239475,
0.034436654,
0.016228009,
-0.020611817,
0.009038301,
0.00906471,
-0.022539634,
-0.03559863,
-0.01918576,
0.033433132,
-0.009612686,
0.029022917,
0.0010282801,
-0.016624136,
-0.021007944,
-0.0040603033,
-0.0015457212,
-0.021879423,
0.016597727,
-0.004040497,
-0.051971883,
0.018908469,
0.026329251,
-0.043283492,
0.0080677895,
-0.01654491,
-0.010893497,
-0.019713929,
-0.0033786346,
-0.011606526,
0.020545796,
0.0106162075,
0.011540504,
-0.0067275595,
0.008404498,
-0.011177388,
0.0072953417,
0.02417696,
0.006489883,
-0.0019558778,
0.0014442136,
-0.01283452,
0.00003174691,
-0.011263216,
-0.015963925,
-0.013125013,
0.032007076,
-0.0053345123,
0.03607398,
-0.003763208,
0.016373256,
0.021324845,
-0.017865336,
-0.042042296,
-0.01959509,
-0.012478005,
0.0073745674,
-0.015224487,
-0.0012923648,
-0.0054533505,
-0.018419912,
0.0014697968,
-0.0035849507,
0.010787863,
0.009566471,
-0.017271144,
-0.013019379,
0.022671677,
-0.010827475,
-0.012821316,
-0.00893927,
-0.009942791,
-0.002155592,
0.009302386,
0.008833636,
-0.010464359,
-0.015105649,
0.01283452,
0.0019542272,
-0.030977143,
0.0047304183,
-0.0015448959,
-0.01984597,
-0.03776412,
-0.007037859,
-0.0028653198,
-0.019951604,
0.017244736,
0.008642174,
-0.0014054262,
0.016676953,
0.004499344,
-0.009942791,
0.006872806,
0.0021737479,
-0.03261447,
-0.0030617327,
0.0141021265,
0.03454229,
-0.01654491,
0.030950734,
0.03776412,
-0.0041296254,
0.016188396,
-0.0124053825,
0.012570435,
-0.044973638,
-0.0020796675,
-0.013917267,
-0.047799345,
0.0020351033,
0.0010439601,
0.011652741,
0.004274872,
0.014075718,
-0.024678722,
0.007638652,
-0.0117781805,
0.031848624,
-0.015422551,
-0.013547549,
-0.01716551,
0.024942806,
-0.000037446396,
0.017271144,
0.02697626,
-0.0059551117,
-0.0199384,
-0.0057801553,
0.016016742,
-0.0006090455,
-0.022579247,
-0.011665945,
0.013125013,
-0.0005459127,
0.012735488,
0.03134686,
-0.0121479,
-0.04415497,
0.0021638446,
-0.00027543216,
0.023384707,
-0.011342441,
-0.032852147,
-0.037367996,
0.0021605436,
0.023780834,
0.013838042,
-0.011864008,
0.0005648938,
0.004317786,
-0.011395258,
0.032297567,
0.0048492565,
0.0012139647,
0.009130731,
0.01654491,
0.0033159144,
0.006413959,
-0.015501776,
-0.0010876992,
-0.0003967461,
0.0014351357,
0.023397911,
0.011051947,
0.005658016,
0.008853442,
-0.0064271633,
0.0010051726,
0.006793581,
0.012570435,
0.019436639,
0.028732423,
0.01448505,
0.025457771,
-0.0059353053,
0.0037731112,
-0.03034334,
0.021179598,
0.0065691085,
0.01672977,
-0.023081008,
-0.009599482,
0.017706884,
-0.009949394,
0.017033467,
0.014669909,
-0.013573958,
-0.0027299763,
0.023754425,
0.005932004,
-0.008133811,
0.024229778,
0.012392178,
-0.015554593,
-0.038978912,
0.011362247,
0.013772021,
-0.007896135,
-0.013732408,
-0.019568682,
-0.0031442593,
-0.020955127,
0.026593337,
0.0069124186,
0.011897019,
0.006100358,
-0.004915278,
0.0011322635,
-0.035281725,
0.0051859645,
0.00016701299,
-0.0057108332,
0.0039051536,
-0.02333189,
-0.000006814883,
-0.003018819,
-0.0052420828,
0.054876816,
0.017772906,
0.0004869063,
-0.0025187086,
-0.016584523,
-0.015264099,
-0.012979766,
-0.0034265,
-0.0022298659,
-0.02504844,
0.000032340067,
0.011910223,
-0.020044034,
0.008080994,
0.028494747,
0.0006024434,
-0.02071745,
-0.03279933,
0.0076584583,
-0.01049737,
0.023318686,
0.007354761,
-0.0057207365,
0.030105663,
-0.0013063943,
0.0026028855,
-0.014339803,
-0.00897228,
0.021351254,
-0.006526195,
-0.010167263,
-0.00021952047,
-0.0005364222,
0.01049737,
0.028864466,
0.002682111,
-0.016690157,
-0.02174738,
0.010041824,
0.018367095,
0.017310757,
-0.025708653,
0.036575742,
0.015303712,
-0.011349043,
-0.0063479375,
-0.00051579054,
0.0058956924,
0.012768499,
-0.009889974,
-0.0066780434,
0.029551085,
0.00931559,
-0.016333643,
-0.02759686,
-0.006628528,
0.011586719,
0.014405824,
0.016029945,
0.017046671,
0.012246931,
0.02186622,
0.006526195,
0.009110925,
0.00005348748,
-0.006149874,
0.005479759,
0.006536098,
-0.0035255316,
-0.023345094,
0.035228908,
-0.013349486,
0.01174517,
-0.03602116,
0.011217001,
-0.0032333878,
0.0046247845,
-0.005535877,
-0.007698071,
-0.003594854,
-0.012530822,
-0.014696318,
-0.02610478,
-0.014313394,
-0.019053716,
-0.004238561,
0.00020332464,
-0.010154059,
-0.020532591,
0.004604978,
0.02844193,
-0.021800198,
-0.012530822,
-0.017297553,
0.019964809,
0.014432233,
0.016703362,
0.0049647936,
0.014683113,
0.032033484,
0.01034552,
-0.014590683,
-0.015594206,
-0.030554608,
-0.022948967,
0.004911977,
0.010768057,
-0.012200716,
-0.0030138674,
-0.013336281,
0.008001769,
-0.015752656,
-0.0047898376,
0.0065823128,
0.0052783946,
-0.006905817,
0.023648791,
0.01439262,
-0.011672547,
-0.011751772,
-0.0033010596,
-0.021272028,
0.001024979,
-0.020492978,
-0.0076320497,
-0.0055688876,
-0.0054929634,
-0.006757269,
-0.012999573,
0.005598597,
0.011236807,
-0.013745612,
-0.0070048487,
0.0066681406,
-0.015594206,
0.009817352,
-0.03554581,
0.0069982465,
0.008681787,
-0.009487245,
0.013204238,
-0.0035156284,
0.042332787,
0.0010513875,
-0.011553708,
0.022249142,
0.012418587,
-0.015633818,
-0.0063974536,
-0.015158466,
0.010107844,
0.030554608,
-0.004710612,
-0.009573073,
-0.011811191,
0.01610917,
-0.00010986339,
-0.014498254,
-0.009566471,
-0.016399665,
-0.021351254,
-0.00035672076,
0.01918576,
0.009084516,
0.008490325,
-0.02963031,
-0.006331432,
0.012781703,
-0.0071765035,
-0.004535656,
0.012359167,
0.01274209,
0.008714797,
0.0062885187,
-0.025682244,
-0.010226683,
-0.021073965,
-0.0041692383,
0.013078799,
0.041118,
0.021734176,
0.005595296,
0.020506183,
0.012946756,
0.006149874,
0.022407593,
-0.016518502,
0.010820873,
-0.007136891,
0.022249142,
0.0020152968,
-0.023358298,
0.019212168,
-0.018485934,
-0.0091439355,
0.018961286,
-0.012332759,
-0.011877213,
-0.009183547,
-0.018235054,
-0.027029077,
0.019911991,
-0.004007486,
0.004090013,
-0.024044918,
-0.0077376836,
-0.004482839,
-0.014854768,
0.010523778,
-0.035915527,
0.026619745,
-0.038081024,
0.037394404,
0.025365341,
0.010028619,
0.037737712,
-0.00897228,
0.011738568,
-0.0065162918,
0.009487245,
-0.0047337194,
0.005100137,
-0.00482945,
0.012590242,
0.000025364001,
-0.0043375925,
-0.012121491,
-0.019529069,
-0.015924312,
-0.018644385,
-0.014009697,
0.0040338947,
-0.055563435,
-0.05566907,
0.0037202942,
0.009031699,
-0.017733293,
0.012484607,
0.0007130289,
-0.04317786,
0.022328367,
0.0020301517,
0.026963055,
-0.026910238,
0.016148783,
0.026923442,
-0.024150552,
-0.024599496,
-0.0017215026,
0.007585835,
-0.008378089,
0.022671677,
0.030554608,
-0.013455119,
-0.029947214,
-0.0024427841,
0.020532591,
0.0004856684,
-0.020625021,
0.021166394,
0.015845086,
-0.013474925,
-0.019014103,
-0.012207318,
-0.0022562742,
0.0013889208,
-0.0054995655,
-0.011032142,
-0.010886895,
0.009487245,
-0.032878555,
0.023014987,
0.011533902,
0.015026423,
-0.005261889,
-0.024507066,
-0.0027002667,
-0.014749135,
-0.0048525576,
0.0022694785,
-0.0048459554,
0.02720073,
-0.005803263,
-0.0011388656,
0.015145262,
0.005994724,
0.022684881,
-0.00009619494,
-0.0094542345,
0.03604757,
0.01071524,
-0.013455119,
0.014247374,
0.016439278,
-0.00032824912,
-0.03541377,
-0.0013377544,
-0.008701594,
-0.03155813,
-0.009249569,
0.029947214,
0.017323961,
-0.0023899672,
0.017535228,
-0.02298858,
0.0006672267,
-0.017310757,
-0.014471846,
0.0005776854,
-0.043125045,
-0.016518502,
0.009810749,
-0.0004831926,
0.015277304,
-0.014088922,
0.0035585423,
0.0031195013,
0.0073745674,
-0.0026160898,
0.023939284,
0.0036707784,
0.007797103,
-0.025616223,
-0.0042550657,
-0.015660226,
-0.02619721,
0.019872379,
-0.0158847,
-0.029471861,
-0.00915714,
-0.011276419,
0.029735945,
0.027808126,
-0.010510574,
0.01327026,
-0.018842448,
0.030052846,
-0.0048492565,
0.0044762366,
0.008041381,
-0.01875002,
-0.008800625,
0.009540062,
-0.024216574,
-0.006146573,
0.022130303,
-0.03153172,
0.014762338,
0.0033786346,
-0.026725378,
-0.011943234,
0.0043606996,
-0.007090676,
-0.018485934,
-0.012913745,
-0.017191919,
-0.01221392,
0.011626332,
-0.02131164,
-0.010206876,
-0.0057504456,
0.02557661,
0.011982846,
0.0029082336,
-0.015911108,
-0.00014514347,
-0.018591568,
-0.025404954,
-0.022737699,
0.0029395935,
-0.007084074,
0.031109186,
0.0155810015,
-0.01576586,
-0.032931373,
0.01716551,
-0.028309887,
-0.017456003,
-0.008206435,
-0.0008368186,
-0.027147915,
0.0072887396,
-0.0030633833,
-0.001741309,
-0.012537424,
0.019119738,
-0.006757269,
-0.025008827,
0.02227555,
-0.018459525,
0.04750885,
-0.000019303461,
-0.024348617,
-0.024467453,
0.027966578,
0.012372372,
0.0047370205,
0.041857436,
-0.015052832,
0.0019492757,
-0.029577494,
0.0076650605,
-0.0032746512,
0.0043441947,
-0.00014349293,
-0.015066036,
0.018934878,
0.0010431348,
0.004598376,
-0.0056811236,
0.01049737,
0.025893511,
-0.0003408344,
-0.00095318095,
0.0027002667,
-0.010880292,
0.0041362275,
0.0032713502,
0.004994503,
0.007803705,
-0.012029061,
0.01725794,
0.008232843,
0.004991202,
-0.018076602,
-0.008833636,
-0.016043149,
-0.014537866,
0.0019822863,
0.0013220743,
0.005932004,
-0.008272455,
0.012154502,
-0.024163757,
-0.004604978,
0.0074339863,
-0.00056283065,
-0.0041098194,
0.008661981,
0.022579247,
0.004047099,
-0.0035156284,
-0.02539175,
-0.0029197873,
-0.009242967,
0.005324609,
-0.0071831057,
-0.0044036135,
-0.020096852,
0.0099692,
0.008589357,
-0.025840694,
-0.02722714,
-0.01261665,
-0.011005733,
-0.01096612,
0.18105651,
-0.0074075777,
0.0034231988,
0.003941465,
-0.01567343,
0.0015036326,
-0.01492079,
0.0008813829,
0.012636457,
-0.0036938856,
0.0055193715,
0.010299306,
-0.009434428,
0.00224307,
0.013639978,
-0.028758831,
-0.017627658,
-0.004753526,
-0.012009255,
-0.022130303,
-0.010708638,
-0.009566471,
0.02108717,
0.008800625,
0.0277289,
0.0060970574,
0.00028616062,
0.0002352005,
0.021113578,
0.029735945,
0.006965236,
0.010636014,
0.009823954,
-0.0076584583,
0.020981535,
-0.002003743,
-0.0063875504,
0.0031128991,
0.014603888,
0.027174324,
-0.00056654436,
-0.032693695,
-0.025946328,
-0.017614454,
-0.0030056147,
-0.0010365327,
0.013072196,
-0.020360935,
-0.013118411,
0.032878555,
-0.027702492,
0.011289624,
0.016597727,
0.011850804,
-0.017178714,
-0.015066036,
0.010517176,
0.016716566,
-0.003763208,
0.021073965,
-0.0155810015,
0.026329251,
0.000595016,
0.032561652,
-0.017205123,
0.022328367,
-0.015158466,
-0.021575727,
0.004090013,
-0.012141298,
0.025101257,
0.0021077266,
0.006248906,
-0.0021258823,
-0.0066516353,
-0.017680475,
0.026606541,
0.019423435,
0.0067803767,
0.027121507,
0.0014590684,
0.015924312,
-0.04286096,
0.0060013263,
-0.009579675,
-0.014286986,
0.008166822,
-0.004911977,
-0.024414636,
-0.0016307235,
-0.021879423,
-0.021892628,
-0.017654067,
-0.032931373,
0.00784992,
-0.020757062,
-0.003165716,
0.021483297,
-0.0051166425,
-0.0075990395,
-0.004803042,
0.075211346,
0.011448075,
0.025325729,
-0.011738568,
0.0015614012,
-0.014669909,
0.010536983,
-0.019225372,
-0.008661981,
0.009566471,
-0.02358277,
0.016148783,
-0.016901426,
-0.0024724936,
0.019621499,
0.025378546,
-0.017389983,
0.016373256,
0.0021853014,
-0.0005760349,
-0.014669909,
0.036364473,
0.015990334,
0.0023123922,
-0.0074339863,
-0.029762354,
0.03134686,
-0.0021737479,
-0.04695427,
-0.011817793,
-0.01071524,
0.012332759,
0.016188396,
0.011448075,
0.0052783946,
-0.0053345123,
0.010147457,
-0.020836288,
0.009975802,
-0.0076716626,
-0.005423641,
0.042596873,
0.008582755,
0.006598818,
0.0153565295,
0.008569551,
-0.009031699,
-0.025695449,
-0.013025981,
-0.0115999235,
-0.024903193,
-0.02759686,
-0.008714797,
0.02931341,
-0.022103895,
-0.0034430053,
-0.02482397,
0.0029131852,
-0.0114216665,
-0.010206876,
-0.0103059085,
0.021575727,
-0.027992986,
0.0023041395,
0.0036344666,
-0.16584523,
0.009797545,
0.011269817,
-0.00045554622,
0.005958413,
-0.0015118853,
-0.0052354806,
0.009348601,
0.00007509911,
0.002850465,
0.03660215,
-0.006100358,
-0.0055292747,
-0.017838927,
-0.011613128,
-0.0038523367,
-0.007797103,
0.018076602,
0.0073745674,
0.016333643,
0.016505297,
-0.022064283,
0.006070649,
-0.038899686,
-0.007533018,
0.02165495,
-0.0054467483,
-0.0023107417,
0.0011594972,
-0.015647022,
0.0058923913,
0.010880292,
0.018023785,
0.0076254476,
0.016676953,
-0.0061696805,
-0.011784783,
-0.011296226,
-0.0031706677,
0.021126783,
0.012847724,
0.012279942,
0.0031442593,
-0.012062072,
-0.0230546,
0.02931341,
0.003938164,
-0.0058428757,
0.040827505,
-0.009308988,
0.038741235,
-0.022381185,
-0.0046346877,
0.035123274,
0.023503544,
0.016003538,
0.013917267,
0.016531706,
0.01560741,
0.02099474,
-0.00884684,
-0.0055589844,
0.013468323,
-0.0062026912,
0.0076650605,
-0.029154958,
0.0064997864,
0.006602119,
-0.019344209,
0.009790943,
-0.024242982,
-0.022222733,
-0.002049958,
-0.0050506215,
0.021826606,
0.020981535,
-0.004192346,
-0.009612686,
0.0076188454,
0.003875444,
-0.014867973,
0.0029726042,
-0.008351681,
-0.021021148,
-0.018406708,
0.005658016,
-0.008166822,
0.0081602195,
-0.007684867,
0.0018436419,
0.008800625,
-0.0199384,
0.0075462223,
-0.014432233,
0.018327484,
0.016175192,
-0.0064964853,
0.008899657,
-0.014207761,
-0.0035255316,
0.02635566,
-0.023622382,
-0.017746497,
0.0024460852,
0.007922543,
0.002418026,
0.017482411,
0.0022166616,
0.05131167,
-0.028019395,
-0.017720088,
-0.007579233,
0.0064535714,
0.03538736,
-0.012715681,
0.020387344,
0.012550629,
-0.0062885187,
0.012332759,
-0.04415497,
0.069507115,
-0.0020895707,
0.016795792,
0.019555477,
-0.0006626877,
0.0022397689,
-0.12031702,
-0.014260578,
0.013917267,
0.032667287,
0.00862897,
0.0151320575,
0.0063578407,
0.02408453,
-0.018261462,
0.03345954,
-0.0018353892,
0.005591995,
-0.010292704,
-0.028125027,
0.019978013,
0.017205123,
0.010464359,
-0.013996493,
-0.016122375,
0.0045488602,
-0.018604772,
0.005057223,
-0.011976244,
0.00535762,
-0.022447206,
-0.0070642675,
-0.03625884,
0.03536095,
0.010477563,
0.035704263,
0.018169032,
0.0036212625,
0.0016950942,
-0.014511459,
-0.008562949,
0.0034000913,
0.013276862,
-0.02080988,
0.049806386,
-0.010008813,
-0.0076320497,
0.009269375,
0.016861813,
-0.016505297,
-0.013745612,
0.008840238,
-0.018789632,
0.012504414,
0.027649675,
-0.01735037,
-0.032931373,
-0.024044918,
-0.02809862,
-0.013250453,
0.0473504,
0.0047733323,
-0.031452496,
0.018604772,
-0.048961315,
0.008490325,
-0.0035090265,
0.008708196,
-0.0055721886,
-0.015066036,
0.018235054,
-0.01327026,
-0.012676069,
-0.032139115,
0.028679606,
-0.03670778,
-0.002043356,
-0.014511459,
-0.020453366,
0.000003212408,
-0.006222497,
-0.009526858,
0.0038358313,
-0.013943676,
0.0052255774,
-0.012590242,
-0.008463917,
-0.015303712,
0.01672977,
-0.021562522,
0.013851246,
0.00928258,
0.012596844,
0.00096308417,
0.013257056,
-0.009731524,
-0.01812942,
0.012266737,
0.013560753,
-0.018340688,
-0.00009830968,
0.009731524,
-0.010880292,
-0.028336296,
0.023094213,
0.018433116,
-0.024665518,
-0.019304596,
-0.056408506,
-0.0013715903,
0.010867088,
0.03192785,
0.0022199627,
-0.028389113,
-0.0010439601,
-0.0028389113,
0.0055622854,
0.006311626,
-0.045158494,
0.0032300868,
-0.019911991,
0.011514096,
-0.026646154,
-0.0021638446,
0.06639091,
0.00044729357,
0.007084074,
0.03850356,
-0.014247374,
0.02289615,
0.0058296714,
0.025603019,
-0.013666387,
0.002812503,
-0.039322224,
-0.0044135167,
-0.012299748,
-0.007156697,
-0.01221392,
-0.037526447,
-0.006103659,
0.014762338,
-0.004096615,
-0.025286118,
-0.0031327056,
0.014841564,
-0.011751772,
0.011857406,
-0.03382926,
-0.027332773,
0.01888206,
0.0023652092,
-0.009203354,
0.003155813,
-0.017997377,
0.017680475,
-0.004463033,
-0.029154958,
0.03607398,
0.01196304,
-0.004687505,
-0.01140186,
-0.01638646,
0.022077486,
0.018961286,
0.01352114,
-0.018802837,
-0.014683113,
0.014960403,
-0.0021687963,
-0.0062059923,
-0.0015242643,
0.027121507,
-0.004007486,
-0.033697218,
0.013996493,
0.019661112,
-0.014815155,
-0.054031745,
-0.011560311,
0.004198948,
0.026250025,
0.0025088054,
0.0056018983,
-0.014973607,
-0.005978219,
-0.013402302,
0.028679606,
0.021800198,
0.023001783,
0.00020951412,
0.026844217,
0.03036975,
-0.010543585,
-0.00077905005,
0.01034552,
0.0094080195,
0.034753557,
-0.008714797,
0.015871495,
-0.009579675,
0.0021687963,
0.01430019,
0.0064337654,
-0.005766951,
-0.004152733,
0.008523336,
0.03279933,
-0.005882488,
0.004717214,
-0.0002607837,
0.007136891,
-0.020757062,
0.005644812,
-0.021021148,
-0.033512358,
-0.021047557,
0.011553708,
-0.0033571776,
0.00090861664,
0.04249124,
0.00028409745,
0.000788128,
-0.0034430053,
0.0015308664,
0.007130289,
-0.021166394,
0.02479756,
0.0018865556,
-0.007995167,
-0.030132072,
-0.011045345,
0.021470092,
0.020347731,
0.020176077,
-0.013587162,
0.029181367,
-0.0062324004,
-0.007995167,
-0.03866201,
-0.004370603,
0.005965015,
0.012359167,
0.0026358962,
0.01071524,
0.013191034,
0.0026920142,
0.09348601,
-0.005169459,
-0.019991217,
0.011725364,
-0.01915935,
0.01482836,
-0.0010951265,
0.033169046,
-0.009071312,
-0.02697626,
0.01348813,
-0.0026590035,
0.037843347,
-0.01641287,
-0.033802852,
0.025972737,
-0.0037467026,
-0.008661981,
-0.008899657,
-0.0057867575,
0.02463911,
-0.017152306,
-0.009176945,
0.024942806,
-0.0027877449,
-0.0067803767,
0.033169046,
-0.0072821374,
0.01109156,
-0.03713032,
0.018776428,
0.0028950293,
-0.040299337,
-0.029075732,
0.02108717,
-0.004264969,
-0.019951604,
-0.018525546,
-0.017205123,
-0.004918579,
-0.0032812532,
0.0367606,
-0.019198963,
-0.012511016,
0.0071170847,
-0.030079255,
-0.04645251,
-0.00376981,
-0.010985927
] |
Exposure during the organogenesis stage of the mouse embryo to the model teratogen, hydroxyurea (HU), induces curly tail and limb malformations. Oxidative stress contributes to the developmental toxicity of HU. Reactive oxygen species (ROS) interact with polyunsaturated bilipid membranes to form α,β-unsaturated reactive aldehydes; 4-hydroxy-2-nonenal (4-HNE), one of the most cytotoxic of these aldehydes, covalently adducts with proteins, lipids, and nucleic acids. The goal of the current study is to determine
|
[
-0.018631173,
-0.022075364,
-0.0048713605,
-0.043445617,
-0.022509279,
-0.00030276505,
-0.0073019555,
0.0021204147,
-0.022821154,
-0.0036645376,
0.0054273126,
-0.0040747216,
0.0010254603,
0.009363046,
-0.017098915,
-0.018373538,
0.035309736,
0.0141564375,
0.012725878,
-0.0040713316,
-0.03715387,
-0.0037357265,
-0.019729517,
-0.014427634,
0.00842064,
0.0020577007,
0.01968884,
-0.048842423,
-0.01613617,
-0.035987724,
0.0153497,
0.021180417,
-0.0035086,
-0.013688624,
-0.00348487,
0.014386955,
0.02309235,
0.010034257,
-0.00489848,
-0.007051099,
0.007329075,
0.020095633,
-0.0071053384,
0.011736012,
-0.012061448,
-0.0051391665,
-0.017641308,
-0.013864902,
0.00016949758,
0.031621467,
0.027011134,
0.011559735,
0.0066714245,
-0.009342707,
-0.005030688,
0.01118006,
0.017817585,
0.01742435,
0.0026272123,
-0.013444548,
0.012475021,
0.011519055,
-0.03148587,
0.015973452,
-0.013912361,
0.014631031,
0.0010364776,
0.010868184,
-0.00697652,
-0.008820654,
0.025058521,
0.0028170496,
-0.013878462,
-0.032977447,
0.0136208255,
0.00701042,
-0.048300028,
-0.015200542,
0.015607337,
-0.0024966993,
0.033357125,
0.0024577149,
-0.018048102,
0.014753069,
0.019621039,
-0.006139202,
-0.01751927,
0.038320012,
-0.007200257,
-0.026007708,
0.009403725,
0.017031116,
0.020014273,
0.0039526834,
-0.0056408793,
0.00028157784,
0.005027298,
0.04764916,
-0.018902369,
-0.021722808,
-0.01616329,
0.008481659,
-0.01473951,
-0.01601413,
-0.04195404,
-0.00051739137,
0.016393805,
0.017166715,
0.00907829,
-0.0195668,
-0.01898373,
0.036177564,
0.0041052313,
-0.0264823,
0.007946046,
-0.007627391,
0.031051956,
0.015851414,
-0.0055459607,
-0.01815658,
0.021790609,
0.031729948,
-0.0017966743,
-0.016190408,
0.012264845,
0.0025339888,
-0.023512704,
-0.0036543678,
0.0017644698,
-0.0066307453,
0.011959749,
0.001469544,
0.016610762,
-0.012495361,
-0.01539038,
0.03769626,
-0.041438766,
-0.015227662,
-0.0021458394,
-0.039296318,
0.014508992,
0.027445048,
-0.028123038,
0.013688624,
0.005386633,
0.026441623,
0.014115758,
0.020882102,
-0.0019899015,
-0.007403654,
0.0046340637,
-0.0167328,
0.02165501,
-0.014088638,
0.008122324,
0.030509563,
-0.011315658,
0.021546531,
-0.029560378,
-0.01953968,
0.021261776,
-0.015159863,
0.0060002143,
0.01471239,
-0.008691836,
0.022712676,
0.013783543,
0.009037611,
0.022563517,
-0.022319442,
-0.0125292605,
0.016054811,
-0.019878676,
0.01464459,
0.019376963,
0.020638024,
0.0053629032,
0.017112475,
-0.0071799173,
-0.02866543,
-0.000049021877,
0.0019899015,
0.020610906,
0.0056849485,
-0.0069833,
0.005871396,
0.015797174,
-0.015878532,
0.006501927,
-0.020475307,
-0.009315587,
0.010827505,
-0.013397088,
-0.008163003,
-0.6348159,
-0.02238724,
-0.005793427,
0.0080341855,
0.0065426063,
0.033167284,
0.0052713747,
-0.0077833286,
-0.01118684,
0.030970598,
-0.017722666,
0.026739938,
0.021031259,
-0.015173423,
-0.00019555783,
-0.006095133,
-0.00070341496,
-0.012644519,
0.03004853,
-0.004840851,
-0.012454682,
0.0048645805,
-0.024624608,
-0.016529404,
0.024109336,
0.025139881,
0.0017407401,
-0.004417107,
-0.006732444,
0.019743077,
0.00979018,
-0.00062544603,
-0.002103465,
0.0059697046,
0.04553383,
-0.003986583,
-0.00279332,
0.034496147,
0.021939766,
0.033845276,
-0.023702541,
0.0036170783,
0.018210819,
-0.015051384,
-0.017492149,
0.005803597,
0.034740224,
-0.01190551,
0.015553097,
0.013607265,
-0.011844491,
-0.007342635,
0.0072680563,
0.0022492327,
0.017315872,
-0.017275194,
0.010773266,
-0.015959892,
0.0019407473,
0.010861404,
-0.019810876,
0.02801456,
-0.01047495,
-0.015742935,
-0.00046738956,
0.008095204,
-0.036123324,
-0.0022526227,
-0.009234228,
0.0013407258,
0.01608193,
0.03791322,
-0.012766558,
0.009024051,
0.0028407795,
0.04892378,
0.01739723,
0.013763203,
-0.01261062,
0.0362318,
0.017980304,
0.001684806,
-0.016407365,
0.025573794,
0.03281473,
-0.038184416,
-0.025750073,
0.01884813,
0.0016305667,
-0.021356694,
0.02164145,
0.009003711,
-0.0154174995,
-0.02717385,
-0.015742935,
0.013668285,
-0.015295462,
0.029126463,
-0.0012491972,
-0.020705825,
-0.020475307,
-0.01895661,
-0.0107325865,
0.004406937,
0.004535755,
0.008332501,
-0.039540395,
-0.01262418,
0.036069084,
-0.01046817,
-0.013925921,
0.013851342,
-0.014915787,
-0.014590351,
0.016339567,
-0.015403939,
0.0049493294,
-0.007478233,
-0.012766558,
-0.033275764,
0.022590637,
-0.0075392523,
0.012942835,
-0.010969883,
0.002447545,
0.007824008,
-0.003708607,
-0.0009932558,
-0.012888595,
-0.013363189,
0.03628604,
-0.0024000858,
0.0058374964,
-0.031865545,
0.013614045,
-0.011010563,
0.021126177,
0.022278761,
0.014183558,
-0.010766486,
-0.038292892,
-0.016542964,
-0.012298744,
-0.0024797495,
-0.011966529,
-0.018224379,
-0.012508921,
0.01467171,
0.007885028,
-0.0077087497,
-0.014061519,
-0.002161094,
-0.020515986,
0.016597202,
0.015729375,
-0.005986654,
-0.006776513,
-0.011824151,
0.0021593992,
-0.0014864937,
-0.00420015,
0.029641736,
-0.018915929,
0.025967028,
-0.04385241,
-0.01598701,
0.006230731,
0.017139595,
0.0025051741,
-0.008339281,
-0.016949758,
-0.026861975,
-0.026767056,
-0.0003053075,
-0.005661219,
0.030428205,
-0.008115544,
-0.01614973,
-0.026211105,
-0.015837854,
0.019173566,
-0.0068239723,
-0.0012898765,
-0.01604125,
0.010264773,
0.016624322,
0.016475165,
0.018075222,
0.01745147,
0.039296318,
-0.016298886,
0.01757351,
-0.028556952,
0.009024051,
-0.005240865,
-0.040381104,
0.008054525,
0.009220668,
0.015702255,
0.04412361,
0.028556952,
-0.03560805,
0.017898943,
0.008922352,
0.008793535,
-0.011281759,
-0.010522409,
-0.020827862,
0.007864688,
-0.0056239297,
-0.008888453,
-0.011525835,
-0.0064815874,
-0.021912647,
-0.010719026,
-0.0080274055,
-0.00022288931,
-0.010983443,
-0.01610905,
-0.026522981,
-0.0040747216,
-0.008068085,
0.017641308,
0.0058374964,
0.006844312,
-0.006779903,
0.015702255,
-0.0022543177,
0.012691978,
0.00772231,
0.009390166,
0.00095427135,
-0.000055457487,
-0.0051357765,
0.011071581,
0.007064659,
-0.007051099,
-0.011322438,
0.017248074,
0.004322188,
0.004325578,
-0.008779975,
0.0023475415,
0.006701934,
0.03292321,
-0.0016212444,
0.041547246,
0.005945975,
-0.0036882672,
-0.011952969,
-0.01955324,
0.00015731493,
-0.01473951,
-0.0074985726,
-0.0052917143,
0.0009957983,
0.01952612,
0.03357408,
0.04811019,
0.0040815016,
0.0182515,
-0.002245843,
0.006491757,
-0.0034696155,
-0.0072409366,
0.0059120753,
-0.012325863,
-0.000120237346,
-0.011295319,
-0.003776406,
-0.03994719,
-0.0090986295,
0.008983372,
-0.015729375,
0.01602769,
0.019878676,
0.0029848523,
0.023255067,
0.032570653,
-0.0007500268,
-0.008752855,
-0.014983586,
0.033980872,
0.0280688,
-0.014427634,
-0.022509279,
-0.005708678,
-0.0027882352,
0.008739295,
0.0069561806,
0.030862119,
-0.0067561734,
0.016502284,
0.0025899229,
-0.035391092,
-0.023417786,
0.0148886675,
-0.026956895,
0.016909078,
-0.023227949,
-0.004328968,
0.0028373895,
-0.01464459,
0.007600271,
0.021031259,
0.018929489,
-0.0015941247,
-0.012569941,
0.005512061,
-0.017139595,
-0.0059290254,
-0.016610762,
-0.0016246343,
-0.007051099,
-0.02028547,
0.013871682,
-0.014251356,
-0.021085499,
0.021288896,
-0.010264773,
-0.022658436,
-0.03224522,
-0.0034001213,
-0.010563089,
0.008624037,
0.041438766,
-0.018509135,
0.027567087,
0.03018413,
0.0076545104,
-0.0055459607,
-0.03777762,
0.008000285,
-0.0007648578,
-0.0046374537,
-0.004834071,
0.009817299,
0.008786755,
0.0052137454,
0.004847631,
0.0101969745,
-0.030536683,
-0.0013042839,
0.007132458,
-0.013166572,
-0.027567087,
0.016326007,
0.042306595,
0.024882244,
0.023661861,
0.0112749785,
0.017763346,
0.008176563,
-0.01757351,
-0.0020153262,
0.009857979,
-0.01880745,
0.0060510635,
0.0055493508,
-0.020624464,
0.021871967,
0.0018475236,
0.022319442,
0.0021254995,
0.013030973,
0.010624108,
0.00048815302,
0.015186983,
-0.00071994093,
-0.0036340281,
0.0059968242,
-0.01472595,
-0.010386812,
-0.017641308,
0.019851556,
-0.022699116,
0.0038238654,
-0.016461605,
0.013559806,
-0.015525978,
-0.005247645,
-0.013871682,
-0.014088638,
-0.007952826,
0.0006940926,
-0.0043967674,
0.014847987,
-0.011593634,
-0.011478376,
-0.011783471,
-0.0050611976,
-0.00913931,
-0.029262062,
0.0048578004,
0.02660434,
-0.0059086857,
-0.0306994,
0.024922924,
0.02382458,
0.022170283,
0.018373538,
-0.012461462,
0.031702828,
0.034658864,
-0.005793427,
0.0021238045,
-0.0006229036,
-0.018726092,
0.0041662506,
0.0064409077,
0.0118173715,
-0.0082036825,
-0.021763489,
0.012142806,
-0.0050069583,
-0.020570226,
-0.0052713747,
-0.012773338,
-0.0134377675,
-0.0045527047,
0.007952826,
0.035987724,
-0.019417642,
-0.0022543177,
-0.024353411,
-0.017220953,
-0.029506138,
-0.008318941,
-0.012488581,
-0.019865116,
-0.0036306381,
0.007057879,
-0.0074578933,
-0.008468099,
0.010902084,
0.0018848131,
-0.009539324,
-0.007905367,
0.016393805,
0.007247716,
-0.010651228,
0.031079076,
-0.01669212,
0.017871825,
0.0056883385,
-0.026712818,
0.023661861,
0.0056171496,
-0.017153155,
0.030211248,
-0.0031340101,
-0.036909793,
-0.03628604,
0.014047959,
0.00841386,
0.034550387,
-0.013186911,
-0.030618042,
-0.0040103127,
-0.017288752,
-0.008081645,
0.0006534132,
-0.015322581,
-0.01613617,
0.0016381941,
0.008278262,
-0.0017966743,
-0.027445048,
0.034007993,
-0.03794034,
-0.0085630175,
0.027499286,
0.0023339817,
0.0058408864,
-0.004064552,
-0.013173352,
-0.02450257,
-0.013112333,
-0.013003854,
-0.03357408,
0.0014136098,
-0.005437482,
0.020380389,
0.02307879,
0.05190694,
-0.01119362,
0.02170925,
0.02928918,
0.022441478,
0.024950042,
-0.003762846,
0.025167,
-0.021939766,
0.015729375,
0.008861333,
0.014942906,
-0.012569941,
-0.02450257,
0.0074646734,
0.021424493,
-0.008224023,
-0.019336283,
0.0051527265,
-0.027634885,
-0.023309307,
0.012190266,
-0.025370397,
-0.0054917214,
-0.039540395,
0.001956002,
0.029912932,
0.013336069,
0.005986654,
-0.019905796,
0.017356552,
-0.013925921,
0.011830931,
-0.018373538,
0.010746147,
0.002228893,
-0.008515558,
0.015268342,
-0.013817443,
0.012841136,
-0.005315444,
0.0022560128,
0.008007065,
-0.008068085,
0.004952719,
0.012041108,
-0.010346132,
0.007057879,
-0.015458179,
-0.0033882565,
-0.008800314,
-0.008617257,
0.025492435,
-0.04537111,
0.0027051813,
0.008902012,
-0.02236012,
0.011430916,
-0.020610906,
-0.0058544464,
-0.000059430087,
-0.0168006,
0.018468456,
-0.013030973,
0.019092208,
0.026522981,
-0.0023255066,
-0.027255211,
-0.0026458572,
0.019621039,
-0.0077087497,
0.03140451,
-0.0009178294,
-0.017953184,
-0.012725878,
0.00210855,
0.019146446,
-0.014590351,
-0.039214958,
0.015159863,
-0.006495147,
0.0063256496,
0.0033577469,
-0.00914609,
-0.031675708,
0.011112262,
-0.02801456,
-0.0036543678,
-0.0076612905,
-0.0057018986,
-0.0022712676,
0.03295033,
-0.010861404,
0.02934342,
-0.0017678597,
-0.0041662506,
-0.0026119577,
-0.028882386,
-0.021397375,
-0.00046145715,
0.0040848916,
0.031648587,
-0.008834214,
0.0057324083,
0.0073087355,
-0.01395304,
0.010217314,
0.00009857344,
0.0032441837,
0.04615758,
-0.01598701,
0.0022831324,
0.034631744,
0.0074646734,
-0.011241079,
0.002720436,
-0.00768163,
-0.036855552,
-0.050795034,
-0.00033200337,
0.013098773,
0.009607122,
-0.00697652,
-0.007613831,
-0.012834356,
-0.0067561734,
-0.030834999,
-0.034658864,
0.0100139165,
-0.03514702,
-0.005105267,
0.004457786,
-0.005952755,
0.0068951612,
0.00024132218,
-0.0102037545,
-0.01888881,
0.030129889,
-0.012875036,
0.01810234,
0.008047745,
0.032407936,
-0.01899729,
0.012969955,
-0.014359835,
-0.025316158,
0.004820511,
-0.01473951,
-0.05106623,
-0.010413931,
-0.012502141,
0.005244255,
0.01951256,
-0.0132614905,
0.020882102,
-0.0181837,
0.01810234,
-0.021356694,
0.0019458322,
0.027702684,
-0.020556666,
0.011146161,
0.015010705,
-0.009437625,
-0.004142521,
0.004122181,
-0.0041052313,
-0.029262062,
-0.023336425,
0.0040781116,
-0.00700364,
0.009234228,
-0.004061162,
-0.004322188,
-0.0146988295,
-0.013410648,
-0.029072225,
0.022536397,
-0.0068205823,
-0.021438053,
-0.027702684,
-0.0014780188,
-0.005823937,
0.0025712783,
-0.012217386,
-0.004057772,
-0.00038136955,
0.0045798244,
-0.040787898,
-0.0067934627,
-0.0068883817,
0.048679706,
0.024272053,
-0.029153584,
-0.006339209,
-0.0011763131,
-0.03232658,
-0.015078505,
-0.014373395,
-0.001083937,
0.0021949937,
0.0072409366,
0.012475021,
0.0089359125,
-0.004491686,
0.0017059931,
-0.0023475415,
-0.020868542,
0.0052951043,
-0.027675563,
0.036448758,
0.019458322,
-0.027512847,
-0.015309021,
0.018319298,
0.0022678776,
-0.003640808,
0.035499573,
0.0007784176,
0.014332715,
-0.008149443,
0.015132744,
0.009668142,
-0.016203968,
0.015214102,
-0.028882386,
0.0030357016,
0.0102037545,
-0.0036475877,
-0.011722452,
-0.004573045,
-0.009227448,
0.008305381,
-0.0105563095,
0.0041086213,
0.014454753,
0.013112333,
-0.013186911,
0.00033348647,
0.011369897,
0.015037825,
-0.0033187626,
0.006569726,
-0.014264916,
-0.016380245,
-0.007403654,
-0.013776763,
0.002515344,
0.008868113,
-0.012163146,
-0.007288396,
-0.00010651863,
0.0027407757,
-0.042360835,
-0.013776763,
-0.014115758,
-0.0126174,
-0.026794177,
0.027716244,
-0.017153155,
-0.012773338,
-0.020854982,
0.0037594563,
-0.016624322,
0.007478233,
0.008007065,
0.012088567,
-0.032706253,
-0.008183343,
-0.008603697,
-0.008013845,
0.014292035,
0.00061019126,
-0.024312733,
-0.01952612,
0.03197402,
0.18343706,
-0.010691907,
0.027824722,
0.0043933773,
0.0016559913,
-0.02798744,
0.0029763775,
-0.0025611084,
-0.0036848774,
0.014264916,
0.021736369,
-0.0049900087,
-0.012936055,
0.0069833,
0.014359835,
0.003762846,
-0.022834713,
0.00068773644,
-0.015959892,
-0.01046139,
0.019132886,
-0.0011568209,
0.0021882136,
-0.0071053384,
0.03655724,
0.01601413,
-0.029045105,
-0.00841386,
0.0010458,
0.004847631,
-0.022902513,
-0.005796817,
0.009213888,
0.0013449633,
0.02798744,
-0.010312232,
-0.012637739,
-0.007322295,
0.01826506,
0.012664859,
0.020692265,
0.026821297,
-0.007281616,
-0.0030187517,
-0.020909222,
0.0148886675,
0.019227805,
-0.021085499,
-0.018698972,
-0.0026238225,
-0.04195404,
0.0293163,
0.02305167,
0.014847987,
0.0056408793,
0.0089359125,
0.020149872,
0.013580146,
0.0016314142,
0.03078076,
-0.0153497,
0.009668142,
-0.023214389,
0.0057290182,
-0.025275478,
0.024841566,
-0.014495432,
-0.019065088,
-0.011010563,
-0.01669212,
-0.02238724,
-0.0068138028,
-0.011241079,
0.003152655,
-0.020909222,
-0.011430916,
0.0069561806,
0.02306523,
0.022753354,
0.015580217,
0.015525978,
-0.013512347,
-0.044367686,
0.01685484,
-0.026685698,
-0.038184416,
0.02236012,
0.008088425,
0.00489848,
0.008325721,
0.010217314,
-0.004773052,
-0.007274836,
0.0010864795,
0.000944949,
0.0029645127,
0.00977662,
0.009512204,
-0.009424065,
0.01682772,
-0.052720524,
0.052666288,
0.0015466653,
-0.010773266,
-0.005403583,
0.00772231,
0.0030407866,
0.005742578,
-0.0029780725,
-0.007064659,
-0.0047052526,
-0.01814302,
-0.002995022,
-0.0061832718,
-0.0003023413,
0.007851128,
-0.015498858,
-0.025722953,
0.021370254,
0.0059697046,
0.015783614,
-0.026197545,
-0.0014915786,
0.014617471,
-0.0036848774,
-0.004684913,
-0.034604624,
0.0100139165,
-0.012780117,
-0.04954753,
0.013559806,
0.014793748,
0.013586925,
0.02092278,
0.00084706413,
-0.018495576,
0.0071934774,
-0.021736369,
-0.018075222,
0.019770198,
-0.019227805,
-0.013010634,
0.0043594777,
0.0029458678,
-0.0026322973,
-0.037533544,
0.021397375,
-0.0056849485,
-0.0082036825,
-0.015580217,
-0.022794034,
-0.01681416,
0.012969955,
-0.019282045,
0.013166572,
-0.022902513,
-0.034740224,
-0.0323537,
0.0019356624,
0.013010634,
-0.016597202,
0.037831858,
-0.0044306666,
0.0033882565,
-0.0040035327,
-0.00157209,
-0.17193834,
-0.0019390523,
0.030590924,
-0.025261918,
0.010895304,
0.012034328,
0.009898659,
0.012298744,
-0.017085355,
-0.005745968,
0.045967743,
0.0016110744,
-0.05657151,
-0.025844991,
0.0037391165,
0.012149586,
0.0014958162,
0.051147588,
0.022319442,
-0.013776763,
0.025289038,
-0.028963747,
0.022902513,
-0.0041086213,
0.02730945,
0.011139381,
0.010074936,
-0.01048173,
-0.0037323367,
-0.011146161,
-0.00069875375,
0.01049529,
0.018943049,
0.016976878,
0.023675421,
0.015159863,
0.006654475,
0.00035403806,
0.0029882423,
0.012739438,
0.01049529,
0.024231374,
-0.0014424244,
-0.009437625,
-0.024583928,
0.04195404,
0.010020697,
0.011397017,
0.04667285,
-0.0056544393,
0.022455039,
-0.018346418,
0.01887525,
0.011729232,
0.022563517,
0.0049256,
-0.008522338,
0.023838138,
0.010637668,
-0.0071731373,
-0.01959392,
-0.022522839,
0.035797887,
-0.0018305738,
0.017193833,
-0.016610762,
0.0043730373,
0.011674993,
-0.048327148,
-0.014929347,
-0.010386812,
-0.009973237,
-0.009695262,
-0.013383528,
0.028529832,
0.0072612762,
-0.014088638,
0.016488723,
0.0022899122,
0.006230731,
-0.009627462,
0.012447902,
-0.03197402,
-0.0016220919,
0.0009822384,
-0.0061934413,
-0.0065934556,
0.00050595024,
-0.0029797673,
0.0003718353,
0.01747859,
-0.027756924,
0.015010705,
-0.024421211,
0.02021767,
0.020543106,
0.011234299,
-0.0074375537,
0.015254782,
-0.00004764471,
0.018061662,
-0.020366829,
-0.01393948,
0.017193833,
0.019444762,
-0.008698615,
-0.013817443,
-0.004495076,
0.06459892,
-0.000594089,
-0.004566265,
0.008190122,
0.00844098,
0.022143163,
-0.010298673,
0.0063324296,
0.01743791,
0.007288396,
0.0053391736,
-0.03202826,
0.06302598,
0.02515344,
0.002871289,
0.011769911,
-0.011919069,
-0.020556666,
-0.13060805,
-0.034740224,
-0.022631316,
-0.017112475,
-0.0053527337,
0.025600914,
0.015892092,
0.039431915,
-0.00559681,
0.031051956,
-0.023661861,
-0.016475165,
-0.015919212,
-0.027702684,
0.01741079,
0.01674636,
0.028095918,
-0.002227198,
-0.0153497,
0.04960177,
-0.019471882,
-0.028990865,
-0.005244255,
-0.009179989,
0.0043730373,
-0.006230731,
-0.043798175,
0.014563232,
0.008773195,
0.004973059,
0.014400514,
-0.0020848203,
0.010719026,
-0.0015415804,
-0.012142806,
0.0028645091,
0.004491686,
-0.022644876,
0.03577077,
-0.022753354,
0.006078183,
0.0089291325,
0.015878532,
0.0091121895,
0.015159863,
-0.0055663004,
-0.015010705,
-0.0035255495,
0.0019305774,
-0.01953968,
-0.016353127,
-0.0049188198,
0.0041459105,
-0.008217243,
0.016963318,
-0.0042171,
0.012217386,
0.024746645,
-0.01747859,
0.000012043597,
0.019485442,
-0.0008593527,
-0.012013989,
0.024190694,
0.03078076,
-0.022509279,
-0.0038543749,
-0.04415073,
0.014766629,
-0.03365544,
-0.008156223,
0.0065561663,
0.013600485,
-0.008088425,
-0.028475592,
-0.005078147,
-0.03137739,
-0.0012034328,
0.011729232,
-0.019200686,
0.0025475486,
-0.004566265,
0.022699116,
-0.013119113,
0.006454468,
0.022929633,
0.01955324,
-0.005478162,
-0.00842064,
-0.008291821,
-0.0046679634,
0.044367686,
-0.008488439,
-0.025343278,
0.0070307595,
0.0034594454,
0.011539395,
-0.010251214,
0.044042252,
0.028855268,
-0.020570226,
-0.018359978,
-0.04824579,
0.02720097,
-0.011288539,
-0.002023801,
0.0004754407,
0.0041526905,
0.011858051,
0.003076381,
-0.0068070227,
0.003361137,
-0.016990436,
0.011729232,
-0.01814302,
-0.020339709,
-0.0022560128,
0.0007407044,
0.019173566,
0.0064442977,
0.025072081,
0.007485013,
0.008278262,
-0.008990152,
0.0051798457,
0.011152941,
-0.007559592,
-0.014820868,
-0.011146161,
0.014115758,
0.006847702,
-0.0050035683,
0.0132614905,
-0.030862119,
0.004688303,
0.009200328,
-0.002940783,
-0.033058807,
0.0022966922,
0.021099059,
0.013695404,
0.0182515,
-0.025573794,
-0.031323154,
-0.023675421,
-0.0041526905,
0.0018322688,
0.004542535,
-0.027078932,
0.0049256,
-0.0082036825,
-0.014983586,
0.042279474,
0.02305167,
-0.009525764,
-0.017492149,
-0.02595347,
-0.004125571,
-0.014807308,
0.0025289038,
-0.01958036,
-0.018658293,
0.012285184,
0.0020712605,
-0.0045764344,
-0.01751927,
0.005881566,
-0.0075053526,
0.0042984583,
-0.01614973,
0.017017556,
-0.023444904,
-0.043445617,
0.0049832286,
0.004542535,
0.0071866973,
0.0061866613,
-0.009335927,
-0.02588567,
0.016665002,
-0.017858265,
0.007898587,
0.0010339352,
-0.021234656,
-0.004267949,
0.018332858,
0.026333144,
-0.007356195,
-0.008664716,
0.007925707,
0.010237654,
0.012969955,
0.0017661648,
0.03135027,
0.00005598717,
0.011498716,
-0.0024933093,
0.0110919215,
0.010583429,
-0.020882102,
-0.0049256,
0.034577504,
0.009213888,
0.011410577,
0.004254389,
-0.016258208,
-0.008847773,
0.010352912,
-0.02025835,
-0.029723095,
-0.00022627927,
0.014129318,
0.0037119968,
0.015092065,
0.021532971,
0.008983372,
-0.0046374537,
0.01678704,
-0.006508707,
-0.0031967242,
0.024665287,
0.03433343,
0.011390237,
0.02027191,
0.0016178543,
-0.015742935,
0.025967028,
0.010441051,
0.05190694,
-0.035879247,
0.039242078,
-0.023485584,
0.03902512,
-0.005030688,
-0.039513275,
-0.011763132,
-0.0040137027,
-0.0377505,
0.0053629032,
0.0064103985,
-0.0032340137,
0.09019983,
0.0044238865,
-0.01262418,
0.00016271767,
-0.0077019697,
0.02790608,
0.007756209,
0.01399372,
0.005044248,
-0.02307879,
0.037397943,
-0.028204396,
0.026916215,
-0.022739794,
-0.025058521,
-0.0042408295,
-0.0021746538,
0.015051384,
0.00078646874,
-0.020597346,
0.038374253,
0.0038136954,
0.0043865973,
0.026807737,
-0.048733942,
-0.0009237618,
0.027472166,
-0.004345918,
-0.0040035327,
-0.016963318,
-0.015403939,
0.005939195,
-0.012217386,
-0.006430738,
-0.007362975,
-0.008149443,
0.011688553,
0.0017644698,
0.01604125,
0.005156116,
0.006234121,
0.008217243,
-0.010319012,
-0.019037968,
-0.026048388,
0.0038340352,
-0.005393413,
0.013675065,
-0.011261419
] |
A small proportion of patients with deep vein thrombosis develop recurrent venous thromboembolic complications or bleeding during anticoagulant treatment. These complications may occur more frequently if these patients have concomitant cancer. This prospective follow-up study sought to determine whether in thrombosis patients those with cancer have a higher risk for recurrent venous thromboembolism or bleeding during anticoagulant treatment than those without cancer. Of the 842 included patients, 181 had known cancer at entry. The 12-month cumulative incidence of recurrent thromboembolism in cancer patients was 20.7% (95% CI
|
[
-0.02823955,
-0.046936613,
0.02305454,
-0.029661871,
-0.023856213,
0.026118997,
-0.016059304,
0.008456348,
-0.027851643,
0.019356504,
0.0029125267,
0.027463738,
0.0061935643,
0.005304613,
-0.019369435,
0.019162552,
0.03933366,
0.021179663,
-0.002288645,
-0.03209275,
-0.010744994,
0.027282715,
-0.030748008,
-0.008734348,
-0.005721612,
0.013874101,
0.026739648,
-0.035066694,
0.015322283,
0.00008546052,
0.012264292,
-0.003142038,
-0.009749369,
-0.021968404,
0.0027234226,
0.004632243,
0.009374392,
-0.0020817616,
0.022214077,
-0.0034297346,
-0.0035170135,
0.013447405,
0.0041118027,
0.009044672,
-0.025097512,
0.008411093,
0.018903948,
-0.01581363,
-0.02032627,
0.017468696,
0.031368658,
0.005003986,
-0.010997132,
0.008171884,
-0.0008816778,
-0.02433463,
-0.010318297,
0.03612697,
-0.003355386,
-0.01512833,
-0.011546666,
0.024166537,
-0.0028123178,
0.010945411,
-0.034575347,
-0.010628622,
0.0027654457,
0.0018053787,
-0.0024001678,
0.036928643,
0.03677348,
0.027127553,
-0.021502918,
-0.01710665,
0.004215244,
-0.022162357,
-0.015555027,
0.016679954,
-0.0031565842,
0.0023128889,
-0.0008493523,
-0.018916877,
-0.009484299,
0.008986487,
0.009115789,
0.024438072,
-0.0010756308,
0.01512833,
0.009161045,
0.014197356,
0.008669697,
0.0012299849,
-0.0049942886,
0.01709372,
0.018335018,
0.006704307,
-0.023778632,
0.0123095475,
0.015632607,
-0.020830547,
0.0019088202,
0.0051074275,
-0.022110637,
-0.02106329,
-0.0327134,
0.012917266,
0.005631101,
0.0044091973,
0.029429128,
0.0038079428,
-0.028161969,
0.056634262,
0.015076609,
-0.01899446,
0.016098095,
-0.011578991,
-0.0022110636,
0.0059834486,
0.0020898432,
-0.0007394456,
0.013718938,
0.0025520977,
0.025731092,
-0.016072234,
0.005062172,
-0.00065297494,
-0.01445596,
-0.004512639,
0.011604851,
-0.0013140312,
0.0031388053,
0.0068788645,
0.008262396,
-0.016602373,
-0.009186905,
0.019149622,
-0.024451002,
-0.017636789,
-0.029273966,
-0.022524403,
-0.02623537,
0.012632802,
0.006057797,
-0.012050943,
-0.011818199,
0.019524597,
0.029868754,
0.008223605,
-0.013007778,
-0.03209275,
-0.016744604,
-0.016046375,
0.008424023,
-0.016162746,
-0.018089345,
-0.010648017,
0.019744411,
-0.00097622984,
-0.015787771,
-0.016796326,
-0.0036172224,
-0.007370212,
0.016162746,
-0.002072064,
0.008656766,
0.015399864,
-0.010143739,
-0.005663426,
-0.009135184,
-0.006293773,
-0.011223411,
0.019744411,
-0.004021291,
0.01313708,
0.0030693056,
0.010951877,
-0.036980364,
0.0024551211,
-0.04934163,
-0.02361054,
-0.020765897,
0.010441134,
0.027463738,
0.009225695,
-0.04934163,
0.0022029823,
0.039256077,
-0.0037756173,
0.0033456883,
-0.017610928,
0.0156196775,
0.03152382,
-0.0069887713,
-0.010033833,
-0.6417515,
-0.014197356,
0.019175481,
0.003007887,
0.018244507,
0.0014821239,
0.023455378,
0.007111608,
-0.03620455,
-0.0057539376,
0.009898066,
-0.0036333853,
-0.00428636,
0.0022401565,
0.02159343,
-0.022175288,
-0.016964419,
0.004150593,
0.014300797,
-0.009038207,
-0.011126434,
0.022705425,
-0.014779215,
0.013757729,
0.012186711,
0.013421544,
0.01845139,
-0.022847658,
0.0002660792,
0.035713203,
-0.011113504,
0.018541902,
0.013912892,
0.023558818,
0.040523235,
0.0030644566,
0.00784863,
0.013550846,
0.0007345968,
0.022227008,
0.011035923,
0.012283687,
0.032584097,
-0.0098916,
-0.014287868,
0.01444303,
0.00821714,
0.010984202,
-0.00953602,
0.013253451,
-0.00409564,
0.02963601,
-0.027101692,
0.004215244,
0.027101692,
-0.008152489,
0.031704843,
-0.016757535,
-0.006768958,
0.012445315,
0.0010295669,
-0.01644721,
0.018528972,
-0.028575735,
0.021257244,
0.028601594,
-0.022446822,
0.012568152,
0.02366226,
-0.0012340257,
0.035842504,
0.01512833,
0.03367023,
-0.025330255,
0.036385573,
0.017546277,
0.014184426,
0.017326463,
-0.030282522,
0.005120358,
-0.005479171,
0.0066267257,
-0.029118802,
0.021761522,
0.03276512,
0.00065055053,
-0.0075512347,
0.013208196,
0.020507293,
-0.003513781,
-0.00593496,
0.015930003,
-0.008747278,
-0.03142038,
-0.002843027,
0.02354589,
0.017171301,
-0.0016251641,
0.010706203,
-0.022666635,
-0.01378359,
-0.009245091,
0.010260111,
-0.020028874,
0.014611122,
-0.0032454794,
-0.031756565,
-0.014274937,
0.010143739,
-0.019395296,
0.015930003,
0.00361399,
0.03553218,
0.0030046545,
0.0040697795,
-0.015580887,
-0.0005168038,
0.010913086,
-0.012432384,
-0.021903753,
0.014869726,
0.025575928,
-0.0022110636,
0.008411093,
0.017856602,
0.015787771,
-0.009503694,
-0.009917461,
-0.012038013,
-0.03431674,
0.01642135,
-0.008107234,
0.039902586,
-0.0012598861,
0.016628234,
-0.036540736,
0.009956252,
0.0019104365,
-0.0151154,
-0.01842553,
-0.004014826,
0.017210092,
0.015309353,
0.0047647776,
0.0030127359,
-0.002767062,
0.0035622693,
0.0051041953,
-0.024515653,
0.009283882,
0.021205522,
-0.013240522,
-0.008617976,
-0.002348447,
0.00022971303,
0.014300797,
0.019951293,
-0.015658468,
0.003924315,
-0.014300797,
-0.003143654,
0.010117879,
0.0058218213,
-0.0027056437,
0.006229122,
-0.022614915,
-0.02169687,
-0.0030887008,
-0.0062064943,
-0.020274548,
0.016123956,
-0.025912113,
0.019304784,
0.031110054,
-0.0049167075,
0.024838908,
-0.019615108,
-0.011973362,
-0.004173221,
0.009736438,
-0.014326658,
-0.02105036,
0.0049005444,
-0.0066784467,
0.033230606,
0.002767062,
0.032351352,
-0.004402732,
-0.010104949,
0.016162746,
-0.020507293,
-0.0024648188,
-0.0042023137,
-0.011566061,
-0.009704113,
-0.014662843,
0.010783784,
0.029532569,
0.0012639267,
0.026713787,
0.054668874,
-0.0122319665,
0.022860589,
0.007984396,
0.0066719814,
0.007822769,
0.009781694,
0.0016938557,
0.06103053,
-0.0029012128,
-0.007622351,
0.008107234,
-0.009781694,
0.008521,
-0.02495528,
0.009839879,
0.020752966,
-0.009568346,
0.02036506,
-0.009064068,
-0.014171496,
-0.0076805367,
0.01444303,
-0.009471369,
-0.019369435,
0.0010885609,
0.0229511,
-0.018722925,
0.0048358934,
-0.022045985,
-0.014779215,
0.03361851,
0.021412406,
0.011663037,
-0.0037174316,
0.012070338,
0.016667023,
-0.018903948,
0.0014716181,
0.0027056437,
0.0024179467,
0.030360103,
0.013706009,
0.0046774987,
0.024088956,
0.0042120116,
0.017843671,
0.011572526,
-0.00021173197,
0.021528777,
0.013292242,
0.02562765,
-0.023287285,
0.004816498,
-0.013537916,
-0.018192787,
-0.005091265,
0.005860612,
0.046859033,
0.019498738,
0.021140872,
0.023248494,
-0.0003725513,
0.0058121234,
0.012548756,
0.0004755888,
0.02697239,
0.009484299,
-0.017972974,
0.0067237024,
-0.008372302,
-0.028601594,
0.016705815,
-0.017895393,
0.017016139,
0.004774475,
0.006044867,
0.004667801,
0.008941231,
0.015011959,
-0.0037335942,
-0.037730314,
0.013524986,
0.030825589,
0.0022223776,
-0.004881149,
0.015891211,
-0.011740618,
0.011326852,
0.027205134,
0.016731674,
0.013524986,
0.007758118,
0.0022934936,
0.012606942,
-0.0021173197,
0.0060254717,
-0.006859469,
-0.0065168194,
-0.02297696,
0.0004444755,
-0.0131564755,
-0.0086632315,
0.00395664,
0.024463933,
0.017274743,
-0.010318297,
-0.025563,
-0.032609954,
-0.0007952071,
-0.0026054347,
-0.022666635,
0.004554662,
-0.009607136,
0.0071697943,
0.022899378,
0.0040633143,
0.0012768569,
0.0015031354,
-0.02297696,
-0.0062420527,
0.00017112307,
0.0014312111,
-0.018709995,
0.03142038,
-0.0013811067,
0.006503889,
0.018787576,
0.013861171,
0.00025274494,
-0.018619483,
-0.005450078,
0.029067082,
0.00918044,
0.020830547,
0.0032487118,
0.0197832,
0.024101887,
0.007085748,
0.040342215,
-0.010337693,
-0.012742708,
0.016770465,
-0.020649524,
0.00063075114,
0.020222828,
0.044350576,
0.039902586,
0.028989501,
-0.0049942886,
0.027049972,
0.011566061,
0.01973148,
-0.00088248594,
-0.031161774,
0.0163567,
-0.009238626,
0.044298854,
-0.0017455765,
-0.03219619,
-0.007829234,
0.008049048,
-0.00493287,
0.003756222,
0.016718745,
0.035351157,
0.00787449,
-0.0008970324,
0.0014659611,
-0.03473051,
-0.0030693056,
-0.007027562,
0.014132705,
-0.031808283,
0.023752771,
0.0077128625,
-0.020533152,
-0.017546277,
0.011682433,
0.0020639827,
0.006704307,
-0.00003315888,
-0.020817617,
0.0060642622,
-0.003384479,
-0.019214272,
0.0015192981,
-0.001554048,
-0.0042928252,
-0.009232161,
-0.03672176,
-0.02367519,
0.004228174,
-0.01283322,
-0.00443829,
0.0056117056,
-0.01080318,
0.030049777,
-0.0024001678,
-0.00361399,
0.025769882,
-0.02099864,
-0.03610111,
-0.00014203013,
0.0018684134,
0.0017972974,
-0.00066186447,
-0.016925627,
-0.016576512,
0.018205717,
-0.023145052,
0.01086783,
-0.015451585,
0.014158566,
0.026636206,
0.0048003355,
-0.009161045,
-0.00607396,
0.01711958,
0.0027234226,
-0.00032972003,
0.011107039,
-0.012244896,
0.010059693,
0.027877504,
-0.022097707,
-0.007693467,
-0.013861171,
-0.017274743,
0.013014243,
-0.0026749345,
-0.0018086112,
-0.00040467476,
-0.0015467748,
0.02826541,
-0.006768958,
-0.004480313,
0.0012219036,
0.009426113,
0.0008517767,
-0.0013600951,
-0.008792534,
0.028860198,
-0.00025981615,
-0.016757535,
0.017003208,
0.023287285,
-0.01830916,
-0.032118607,
0.01709372,
0.007906815,
-0.016744604,
-0.03563562,
0.0022417728,
0.005485636,
0.047505543,
-0.010686807,
0.012697454,
-0.04197142,
-0.013434474,
-0.0036689434,
-0.013434474,
-0.019589247,
-0.015839491,
0.0013083743,
0.01971855,
-0.025252674,
-0.020481432,
0.018722925,
-0.02489063,
-0.004037454,
-0.018813437,
-0.02099864,
-0.016550653,
0.010208391,
0.0032390142,
-0.022899378,
-0.006710772,
-0.017856602,
-0.029299825,
-0.015930003,
0.0042669647,
0.041609373,
0.0229511,
0.038945753,
-0.0007050998,
0.008449883,
-0.0002802216,
-0.0005604432,
0.012296617,
-0.004641941,
0.024864769,
-0.010014437,
0.02821369,
-0.011908711,
-0.014520611,
0.01213499,
0.0030353637,
0.042979974,
0.016046375,
-0.021916684,
-0.018722925,
-0.007719327,
-0.03822166,
-0.015723119,
-0.014818005,
0.010130809,
0.015503306,
-0.022459751,
-0.003924315,
0.02231752,
0.02893778,
-0.0017261812,
0.010421739,
0.010505785,
0.011482014,
0.0072667706,
-0.006284076,
0.0054630083,
-0.013408614,
0.001636478,
-0.024192398,
-0.020882268,
0.022563193,
-0.005837984,
0.010395878,
0.007299096,
-0.007363747,
-0.036670037,
0.009956252,
-0.033282325,
-0.023804491,
0.0051138927,
-0.017223023,
-0.015529166,
0.005033079,
-0.010473459,
0.0006214576,
-0.036566596,
0.010531645,
-0.0049845907,
0.010208391,
-0.013369824,
-0.016848046,
0.00015263693,
-0.022214077,
0.003992198,
-0.017662648,
0.041790396,
0.0036010598,
0.002577958,
0.00410857,
-0.023455378,
-0.0045578945,
-0.0032697234,
0.014727494,
0.025808673,
-0.01776609,
-0.027489599,
-0.012018618,
0.011953967,
-0.035739064,
-0.026481044,
0.02891192,
-0.014210287,
-0.0025520977,
0.007997327,
-0.03620455,
-0.034601208,
0.02101157,
-0.010725598,
0.015438654,
-0.012723314,
-0.028601594,
-0.015425725,
0.01647307,
-0.024606165,
0.027360296,
-0.0096394615,
0.00030284945,
-0.0005067021,
0.011152294,
-0.00854686,
-0.0047421497,
-0.0039081518,
0.020895198,
-0.0053337063,
-0.016835116,
0.004351011,
-0.013602567,
-0.025575928,
-0.008792534,
-0.038454406,
0.033153024,
0.0068853297,
0.008611511,
0.029894615,
0.0018296229,
-0.01219964,
0.0024438072,
-0.014287868,
-0.007034027,
-0.039850865,
-0.00655561,
0.012186711,
0.03677348,
-0.019304784,
0.017856602,
-0.019537527,
-0.009348532,
-0.0039469427,
-0.021800311,
0.021412406,
-0.026998252,
-0.0023145052,
-0.023119193,
0.00044285925,
-0.005046009,
0.007234445,
0.0044932435,
-0.009451974,
0.022912309,
-0.01569726,
0.01283322,
0.018865157,
0.017804882,
-0.008184815,
0.005272288,
-0.008980022,
-0.025162162,
-0.008611511,
0.014727494,
-0.017662648,
-0.016059304,
-0.020054735,
-0.0011200783,
-0.018011764,
-0.02492942,
0.030954892,
0.0105381105,
0.009904531,
-0.005033079,
-0.026817229,
0.027489599,
-0.019304784,
0.01771437,
-0.0006303471,
-0.0018813437,
-0.008275326,
-0.0036721758,
0.014559401,
-0.012813825,
-0.0023775399,
0.001324537,
-0.0071245385,
0.03025666,
-0.01380945,
-0.0034426649,
-0.019020319,
-0.0071827243,
-0.012354803,
-0.0005374113,
-0.0035008509,
-0.021567568,
-0.0012170548,
-0.008682627,
-0.00394371,
-0.011766479,
-0.008908905,
0.0059284954,
-0.005741007,
-0.023765702,
0.0014958621,
0.0019524597,
-0.019240133,
0.02037799,
0.018968599,
0.0040600817,
-0.012710383,
-0.019304784,
-0.03149796,
-0.014132705,
-0.006652586,
0.023972584,
0.013537916,
0.026468113,
0.0013293859,
0.02507165,
0.0015330365,
-0.002571493,
0.0040115938,
0.0044770804,
0.011430294,
0.003649548,
-0.0051688463,
-0.0006663092,
-0.05699631,
-0.009374392,
0.009245091,
-0.007577095,
-0.00524966,
0.009600671,
-0.023416586,
0.0067883534,
-0.010331227,
-0.0010457296,
-0.016563581,
-0.007421933,
-0.017520417,
-0.0012356419,
-0.0068723997,
-0.005805658,
-0.0056537287,
-0.015231771,
-0.014908517,
0.0019880177,
0.004296058,
-0.014753355,
-0.018865157,
0.0002007211,
-0.013654288,
-0.0077904435,
-0.0034232696,
0.011191085,
0.0017035534,
0.014947307,
0.0096136015,
0.011727689,
-0.0190979,
0.0101696,
0.006956446,
-0.028498154,
0.016615303,
-0.011856991,
-0.016835116,
-0.0010861366,
0.0047809402,
0.013162941,
0.014274937,
0.0046904287,
-0.013576707,
-0.025873324,
0.046057362,
-0.007027562,
-0.009717043,
0.012723314,
-0.0045805224,
-0.02756718,
-0.025433697,
-0.038531985,
-0.0071891895,
-0.005120358,
-0.014546472,
0.0028026202,
0.005023381,
0.01282029,
0.0023775399,
-0.019899573,
-0.004532034,
0.017972974,
0.18216062,
-0.0046774987,
0.00034992344,
0.02764476,
0.01515419,
0.013408614,
0.033773676,
-0.002847876,
-0.021153802,
0.0057022166,
0.038376823,
-0.00066065224,
-0.0057022166,
-0.0047130566,
0.009736438,
0.008016722,
-0.028679177,
-0.032015167,
0.013602567,
-0.00027618092,
-0.019847851,
0.0037335942,
0.026170718,
-0.00656854,
0.021580499,
0.0069629108,
0.0129237315,
0.004913475,
0.049574375,
0.001871646,
-0.009122253,
-0.0059834486,
0.0018651809,
0.008081373,
0.0032341655,
-0.014378379,
0.016175676,
-0.0030418287,
-0.02300282,
-0.014249077,
-0.021425337,
0.0025456324,
-0.03679934,
-0.015632607,
-0.00055317,
0.020171108,
-0.00046871963,
-0.013408614,
-0.011779409,
-0.012238431,
-0.027851643,
-0.021192592,
0.0051235906,
0.0088183945,
-0.0138999615,
-0.0065426794,
0.03863543,
-0.00018587158,
-0.024800118,
0.035790786,
0.0043316158,
0.00091077073,
-0.010253646,
0.013318103,
0.0027573644,
0.0064650984,
-0.031472098,
0.00028163585,
0.00063479185,
-0.0008453116,
0.010253646,
-0.017921252,
-0.012619872,
0.019007389,
-0.008107234,
-0.03555804,
0.00085500925,
0.015322283,
0.0047001266,
0.011721224,
0.0184126,
0.002359761,
-0.006840074,
-0.007415468,
-0.03098075,
-0.020132316,
0.017326463,
0.026416391,
-0.01710665,
0.009626531,
0.0026991786,
-0.001942762,
-0.008902441,
0.00918044,
0.021205522,
-0.003277805,
-0.008857185,
-0.002288645,
-0.003125875,
0.003237398,
-0.04062668,
0.08927008,
0.0087149525,
0.008339977,
-0.0054533104,
0.016188607,
-0.019964224,
0.009962716,
-0.0025520977,
0.008753743,
-0.00788742,
-0.015399864,
0.02362347,
-0.0072603053,
0.0021787381,
0.022808867,
0.0066655166,
-0.021231383,
0.01313708,
-0.008359373,
-0.0047356845,
-0.04334202,
0.018916877,
0.029299825,
-0.028653316,
-0.008811929,
-0.01715837,
-0.014404239,
-0.01446889,
-0.017235951,
0.0022498542,
-0.013964612,
-0.018709995,
-0.013473265,
0.0065847025,
0.0020413548,
-0.014391309,
-0.026481044,
-0.0033101304,
0.008443419,
-0.00037335942,
-0.019628039,
0.0014999028,
-0.002000948,
0.009684717,
-0.017921252,
0.0059608207,
0.0025149232,
-0.027463738,
-0.0055244267,
-0.002695946,
-0.007945606,
-0.01086783,
-0.011404433,
0.02044264,
-0.04401439,
-0.009089928,
-0.05133288,
-0.0065653073,
0.026209509,
-0.041092165,
0.014106845,
0.026791368,
-0.031989306,
-0.00005692317,
0.030023918,
-0.16033444,
0.0052819853,
0.02169687,
-0.016085165,
0.053686175,
0.0076805367,
0.010835505,
-0.00067075394,
-0.01052518,
-0.004302523,
0.0217098,
0.0010012821,
-0.02566644,
-0.0006788353,
0.003001422,
0.014262007,
-0.024463933,
0.026817229,
0.03886817,
0.030773869,
0.040471517,
-0.022252869,
0.006358424,
-0.022795936,
-0.0033618512,
-0.01219964,
0.00089541613,
0.005256125,
0.0015863735,
0.012542291,
0.009574811,
0.017300604,
0.041505933,
-0.011727689,
-0.01643428,
0.00921923,
-0.0025682603,
0.0044641504,
0.0062905406,
0.003743292,
0.022821797,
0.03351507,
0.014326658,
0.008521,
-0.0055696825,
0.032118607,
0.017429905,
-0.008275326,
0.023429517,
0.004955498,
0.020300409,
-0.01118462,
0.022485612,
0.0000066797597,
-0.0044867783,
0.012684523,
0.014352518,
-0.005010451,
0.023558818,
-0.01152727,
0.0039275475,
-0.041118026,
0.0177273,
0.0024922953,
-0.027308576,
-0.033877116,
-0.016098095,
-0.021218453,
-0.004030989,
0.024373421,
-0.01969269,
0.0051235906,
-0.0056246356,
-0.002889899,
0.031472098,
0.025136303,
-0.014236147,
0.0021496452,
-0.0140292635,
-0.002755748,
0.01184406,
0.022097707,
-0.0073184916,
-0.005634333,
-0.0006562075,
0.026209509,
0.018296229,
-0.01973148,
-0.00062792265,
-0.020248689,
0.021283103,
-0.04396267,
-0.0063002384,
-0.010583366,
-0.0029545499,
0.020171108,
0.006904725,
-0.00045578944,
-0.00060893147,
-0.015580887,
0.016214468,
-0.002689481,
-0.023313144,
0.0044738483,
0.01776609,
0.0131047545,
0.014016333,
-0.020765897,
0.03537702,
-0.0007600531,
-0.009477834,
0.013680148,
0.0067237024,
-0.009044672,
-0.01775316,
0.016990278,
-0.0060836575,
0.0048585213,
-0.0065814704,
-0.016563581,
0.04652285,
0.012031548,
-0.006762493,
0.02433463,
-0.011055319,
0.00443829,
-0.13126735,
0.0056892866,
0.01576191,
0.020158177,
0.015231771,
0.0104605295,
-0.021890823,
-0.013227591,
0.011533735,
0.018218648,
-0.020688314,
-0.022653705,
-0.01709372,
0.011772945,
0.027308576,
-0.007156864,
0.007945606,
-0.03478223,
-0.012425919,
0.033954695,
-0.0139775425,
0.0020979245,
0.015839491,
-0.028679177,
0.008566256,
0.01080318,
-0.01049932,
-0.002219145,
0.015981723,
0.02093399,
-0.0030806193,
-0.0045805224,
-0.009141649,
0.0025116906,
-0.029144663,
-0.0068206787,
-0.02555007,
-0.015981723,
0.03607525,
-0.031265214,
0.0013617113,
0.018632414,
-0.0064424705,
0.0041279653,
0.019977154,
-0.021632219,
-0.046471126,
0.011029458,
0.004532034,
-0.014430099,
-0.0045417314,
-0.02630002,
-0.0078033735,
0.0034232696,
0.021813242,
-0.02492942,
0.018347949,
0.021192592,
0.0035525716,
-0.0013859555,
-0.0095877405,
-0.01283322,
-0.021438267,
0.03496325,
0.022214077,
-0.023429517,
0.003390944,
0.0011087643,
0.0021011569,
-0.01441717,
-0.0076676067,
-0.0101696,
-0.021981334,
-0.015671398,
-0.037807897,
0.001706786,
0.002353296,
-0.0019379132,
0.010686807,
-0.016860977,
0.0051947064,
-0.01444303,
0.016292049,
-0.0057119145,
0.002653923,
0.03289442,
-0.007402538,
0.004784173,
-0.019214272,
-0.008081373,
-0.008230071,
0.018865157,
-0.012542291,
-0.041842118,
0.013718938,
0.02300282,
0.005815356,
-0.024864769,
0.0066913767,
0.0302308,
-0.009148114,
-0.0210245,
-0.046367686,
0.019589247,
0.007402538,
-0.015192981,
0.004037454,
-0.008139559,
0.03866129,
0.01832209,
-0.010040298,
-0.0014497984,
-0.0068853297,
0.027799923,
-0.008113698,
0.012678058,
0.0030822356,
0.0104346685,
0.008624441,
0.018283298,
0.045281548,
0.016757535,
-0.0075253746,
0.0053013805,
0.004884382,
0.022614915,
0.0036948037,
0.0021771218,
0.023933794,
0.033592653,
-0.03165312,
0.024373421,
-0.0009778461,
-0.025097512,
-0.0065653073,
-0.021994265,
-0.001824774,
-0.0131823355,
-0.0035105485,
0.0139516825,
0.024438072,
0.027153414,
-0.01770144,
0.0032939676,
0.04318686,
-0.01642135,
-0.021968404,
0.017274743,
-0.013421544,
0.023080401,
-0.019744411,
-0.0021738894,
-0.02306747,
0.001041689,
0.016641162,
-0.047557265,
-0.022783007,
0.016615303,
-0.010214855,
-0.016460141,
-0.0155679565,
-0.03431674,
0.015516236,
0.0003248712,
-0.013460334,
-0.00085500925,
0.0077775135,
-0.031937584,
-0.01051225,
-0.02499407,
0.009335602,
-0.0052787527,
-0.012652198,
-0.016227396,
-0.010887226,
0.002836562,
-0.005938193,
0.003549339,
-0.01444303,
0.023261424,
0.0024712838,
0.01971855,
0.0002907274,
-0.012626337,
-0.006219425,
0.0112815965,
0.029273966,
0.010964807,
-0.0069305855,
0.017404044,
-0.0011451306,
0.0011402817,
-0.0038111755,
0.017352324,
-0.0021577266,
0.0019039714,
0.008999417,
0.017235951,
-0.005142986,
0.01515419,
0.004939335,
0.03361851,
0.019809062,
0.01313708,
-0.0128720105,
-0.028472293,
-0.0243217,
-0.015180051,
-0.017675579,
-0.040600818,
-0.01444303,
0.004997521,
0.028187828,
0.009005882,
-0.011139365,
-0.0013512055,
-0.015283492,
-0.024257049,
-0.018205717,
0.00540159,
-0.022795936,
0.024257049,
-0.01781781,
0.019240133,
0.007098678,
-0.0016025363,
0.009258021,
0.00047599286,
0.0009980495,
-0.01247764,
0.005340171,
-0.0036592458,
-0.01380945,
0.0032341655,
-0.054979198,
-0.007021097,
-0.0032115376,
-0.03672176,
0.0040827096,
0.01770144,
-0.0075512347,
0.06909897,
-0.0115143405,
-0.037368268,
0.018839296,
-0.037161384,
0.004890847,
0.02240803,
-0.00691119,
-0.032558236,
-0.026041416,
-0.014197356,
-0.012736244,
0.010861365,
-0.055392962,
-0.039152637,
0.03165312,
0.010001508,
0.023558818,
-0.000653379,
0.010001508,
0.0024227956,
-0.025407836,
0.016292049,
-0.0014578797,
-0.017248882,
-0.013499126,
0.018878087,
0.003837036,
-0.039230216,
-0.024205329,
-0.010079089,
-0.025045792,
-0.019227203,
-0.018658275,
0.020222828,
-0.0030563753,
-0.005892937,
-0.05766868,
-0.003195375,
0.0012025083,
-0.019563388,
0.03873887,
-0.028110247,
-0.020765897,
-0.027179273,
-0.014895586,
-0.009413184,
-0.009238626,
0.008960626
] |
BACKGROUND Multilevel models (MLM) offer complex survey data analysts a unique approach to understanding individual and contextual determinants of public health. However, little summarized guidance exists with regard to fitting MLM in complex survey data with design weights. Simulation work suggests that analysts should scale design weights using two methods and fit the MLM using unweighted and scaled-weighted data. This article examines the performance of scaled-weighted and unweighted analyses across a variety of MLM and software programs. METHODS Using data from the 2005-2006 National Survey of Children with Special Health Care Needs (NS-CSHCN: n = 40,723) that
|
[
-0.008165288,
0.011870544,
0.0069370638,
-0.04004422,
-0.0018972286,
0.023699919,
0.0007526303,
-0.009743453,
-0.016495254,
-0.0409225,
-0.008419166,
0.03469218,
-0.0138672665,
0.011843098,
-0.013174246,
-0.0040071667,
0.025182022,
-0.0064464603,
-0.0069267717,
-0.007952578,
-0.016714824,
0.010875614,
0.00099493,
-0.03620173,
-0.011301033,
0.03148096,
0.019047763,
-0.039495293,
-0.015013151,
-0.013050738,
0.0025936796,
-0.012549842,
-0.03260626,
-0.01016201,
-0.029010788,
0.013187969,
0.02058476,
0.00029697805,
0.005973011,
-0.016358022,
0.004432585,
0.011500019,
0.010690352,
0.001998437,
0.006648877,
0.006556246,
0.00010924932,
-0.009400373,
-0.010127702,
0.0025439332,
0.010806998,
0.0058838106,
-0.026005413,
0.009942438,
-0.012783135,
0.0076369457,
0.010436473,
-0.00011804073,
0.01963786,
-0.02607403,
0.014491671,
0.015671864,
-0.025497654,
0.015548355,
-0.00064541795,
-0.017291198,
0.002686311,
0.019843709,
0.016042389,
0.0119391605,
0.028297182,
0.033319864,
-0.014162314,
0.01237144,
0.017963633,
0.0044222926,
-0.0065768305,
0.004710479,
-0.0009820645,
-0.008103534,
0.004676171,
-0.001176762,
-0.008227042,
0.0143544385,
0.0032266611,
0.012138147,
0.017551938,
0.01258415,
-0.0089955395,
-0.010909922,
-0.011081462,
0.0064670453,
0.0077261464,
-0.0022351618,
-0.011911714,
0.0045698164,
0.006257767,
0.033072848,
0.0065802615,
-0.00089029083,
-0.020214234,
0.0017411276,
-0.027460068,
-0.006772386,
-0.02028285,
-0.012247932,
-0.020227958,
0.0030259597,
-0.0015189837,
-0.021819845,
-0.03109671,
0.02205314,
-0.0041272445,
-0.02444097,
-0.018787025,
-0.005921549,
0.005125605,
0.0031203064,
-0.0025182022,
-0.0066900468,
0.025291808,
0.010498228,
0.045698166,
-0.002413563,
0.030547783,
-0.00078779587,
-0.024193954,
-0.0027171883,
-0.027748255,
0.003067129,
-0.0012899783,
0.024550756,
-0.0024067014,
0.005588762,
-0.04687836,
0.031041818,
0.014052529,
-0.0056333626,
-0.041196965,
-0.021861015,
-0.0074585443,
0.018924255,
-0.012659627,
-0.018636068,
-0.00848092,
0.020708269,
0.014683795,
0.026609233,
-0.018828193,
-0.022437388,
-0.017661724,
-0.018979149,
0.0060965195,
0.008741661,
0.017922465,
0.00032656864,
0.014738687,
0.03658598,
-0.03469218,
-0.020365188,
-0.0065287994,
0.0054755462,
0.003300423,
0.0046521556,
-0.009510159,
0.030932032,
0.0039694277,
-0.016865779,
-0.006985095,
0.009400373,
-0.00384935,
0.04191057,
-0.032331795,
0.015562078,
-0.022245264,
-0.009551329,
-0.0013320055,
-0.006556246,
-0.023905767,
-0.0148347495,
0.021119963,
0.013181108,
-0.009633668,
0.0062371823,
-0.0026743033,
0.004161552,
0.021737507,
-0.016714824,
0.012700796,
-0.02643083,
0.017812679,
0.01967903,
-0.014189761,
-0.008192734,
-0.6332421,
-0.019239888,
0.006089658,
0.011829375,
-0.012570427,
0.00274635,
0.017016735,
-0.008199596,
0.008192734,
0.03049289,
-0.014079976,
0.006168566,
0.010621736,
-0.035350893,
0.00039711432,
-0.0048888805,
-0.003962566,
-0.036091946,
0.014162314,
-0.015218999,
-0.036887888,
0.03087714,
-0.0050055273,
0.009263142,
-0.021874737,
0.010134563,
0.007218389,
-0.008748523,
0.028050166,
0.0052696983,
-0.026842527,
0.030026302,
-0.007973163,
0.001563584,
0.042761408,
-0.0026399954,
-0.011513742,
0.028901001,
0.036476195,
0.010271795,
-0.0402089,
-0.040510807,
0.023837151,
0.00069730874,
-0.016138451,
0.040016774,
0.006816986,
0.023809705,
0.014326992,
-0.007684977,
0.012591011,
-0.0026897418,
-0.007616361,
0.0039076735,
0.028599093,
0.002456448,
0.01344871,
-0.00020338171,
0.0055064233,
-0.0009288873,
-0.0058357795,
-0.008926924,
-0.026664125,
-0.018581176,
-0.001410056,
0.0066728927,
-0.013716311,
0.023041207,
-0.015122937,
-0.0037429954,
0.023233332,
0.023727367,
-0.002382686,
0.0033793314,
-0.010422749,
-0.0033484541,
0.0009657683,
0.013565357,
-0.0020516145,
0.017963633,
0.029477375,
-0.013661419,
0.003447947,
-0.0022506004,
-0.00013658845,
-0.02050242,
-0.01280372,
-0.0028492738,
0.006741509,
-0.002231731,
-0.0033467389,
0.015520909,
-0.007986886,
-0.04355735,
-0.020598482,
0.016083559,
-0.021572828,
-0.0017316929,
0.029257804,
-0.04160866,
-0.023727367,
0.0068753096,
0.012522396,
-0.0037121184,
0.005725994,
0.020200511,
0.00053348835,
-0.0051187435,
0.042980976,
-0.012735104,
0.020296574,
0.022204094,
-0.006041627,
-0.0012119277,
0.008583845,
-0.028901001,
0.0021116533,
-0.01807342,
-0.012995845,
0.0014718103,
0.035405785,
0.016220791,
0.031508405,
-0.0047413562,
-0.0015713033,
0.021655167,
0.0053794836,
-0.009640529,
0.0133800935,
-0.018759577,
-0.0043914155,
0.0016382037,
0.01873213,
-0.027350284,
0.021339534,
-0.0029521976,
0.013805512,
-0.01029238,
-0.0015567224,
-0.01158922,
-0.012735104,
-0.0133595085,
0.01915755,
-0.036256623,
-0.010505089,
-0.048195783,
-0.015040598,
-0.0019229596,
0.022327602,
-0.003866504,
-0.01513666,
-0.011253002,
-0.012096977,
0.012467503,
0.0021596844,
0.00036216312,
0.0070091104,
-0.035570465,
0.0016613617,
-0.01811459,
0.001680231,
0.035268553,
-0.036997676,
0.0070605725,
0.0033415926,
-0.00972973,
-0.017003011,
-0.002223154,
0.01716769,
-0.017716616,
0.002763504,
-0.027995273,
-0.008508367,
0.03252392,
-0.028187398,
-0.0008276789,
0.010806998,
-0.019075211,
-0.020955285,
-0.005907826,
0.014066252,
0.019130103,
-0.01453284,
0.0019555523,
0.020625928,
0.015246445,
0.0052902834,
-0.002729196,
-0.039495293,
0.020145617,
0.013846681,
0.026307322,
-0.017332368,
0.029642053,
0.011966607,
0.010175733,
-0.00782907,
-0.0038321961,
0.012302824,
0.0042713378,
0.00196756,
-0.009304311,
-0.0022608927,
0.0050398353,
0.01941829,
-0.028077612,
0.015232722,
-0.011843098,
0.006631723,
-0.003852781,
0.0018320436,
-0.0005515,
-0.023494072,
0.0018063126,
0.0020001524,
0.024207678,
-0.013846681,
0.00419586,
0.027007204,
0.018883087,
-0.0043365224,
-0.040428467,
0.030383104,
-0.016906949,
-0.0017179697,
0.012838028,
-0.020776885,
0.022835359,
-0.0024341478,
-0.006648877,
0.006521938,
0.014546563,
0.003403347,
0.020529866,
0.03260626,
-0.00384935,
0.017181413,
-0.01171959,
0.02456448,
0.012460641,
0.0059489952,
0.02010445,
-0.0020842068,
0.0028835817,
0.036476195,
-0.026705295,
0.043914154,
0.009400373,
-0.014601456,
-0.009716006,
-0.029669499,
0.0061479816,
-0.003235238,
0.010882476,
0.024413524,
-0.003749857,
0.010656044,
0.0040071667,
0.046027523,
0.02162772,
0.004830557,
0.01228224,
-0.01596005,
-0.0007539168,
0.011005985,
-0.016385468,
-0.022862807,
-0.017812679,
-0.0056127775,
0.0017891587,
0.012000915,
-0.0148347495,
0.0109373685,
-0.039001256,
0.015150383,
-0.0060965195,
0.026705295,
0.005873518,
0.029312698,
0.01919872,
-0.013297754,
-0.009283726,
0.016207067,
0.014217207,
-0.0040003047,
-0.0165227,
-0.028050166,
0.008460336,
0.008597568,
-0.00700568,
0.01855373,
0.0013671711,
-0.0024101322,
-0.006041627,
-0.016769717,
0.015616971,
0.023919491,
0.008096672,
-0.005012389,
0.00004441269,
0.0075271605,
0.011582358,
-0.011520604,
-0.051022757,
0.049101513,
0.018032249,
-0.026142644,
-0.036531087,
0.004830557,
0.006741509,
0.00064456026,
-0.007616361,
-0.007287005,
0.017153965,
0.011644112,
-0.009510159,
0.010738383,
0.021792399,
0.0094964355,
0.007767316,
0.007781039,
-0.045176685,
-0.02002211,
0.022368772,
0.059723247,
0.025909351,
0.0066591697,
0.01873213,
-0.014121145,
-0.00830252,
-0.0017874433,
-0.0114245415,
0.0020121601,
0.009523882,
-0.021751229,
-0.011541189,
0.016508978,
0.008631876,
0.025209468,
0.020639652,
0.01154805,
-0.025415316,
-0.018128311,
0.025744673,
0.005760302,
-0.027528685,
0.019102657,
0.05791179,
0.001273682,
0.015589524,
0.012261655,
0.0061788587,
-0.04182823,
-0.030053748,
-0.02737773,
0.026060306,
0.0052902834,
0.04243205,
-0.024537032,
0.0386719,
-0.0012771128,
0.02430374,
0.0020773453,
-0.010196318,
0.014944536,
-0.0021957078,
-0.011253002,
0.012117562,
-0.00062268897,
-0.018992871,
0.0007054569,
0.032331795,
0.0007414802,
-0.0043674,
0.02846186,
-0.024770327,
-0.010175733,
-0.017030457,
0.01072466,
-0.018004803,
-0.013606526,
-0.023754813,
-0.009633668,
-0.017757786,
-0.02365875,
-0.014079976,
0.011582358,
-0.015671864,
-0.013702588,
-0.0063298135,
-0.020941561,
0.014258376,
-0.03213967,
-0.01543857,
-0.01678344,
-0.023082377,
-0.012193039,
0.0109510925,
0.024619373,
-0.0019160981,
0.021092517,
-0.003295277,
-0.0043365224,
0.032880723,
-0.02140815,
0.0016356307,
-0.028873555,
-0.04108718,
-0.0242214,
0.005701978,
-0.0375466,
0.01626196,
-0.027185606,
-0.0027532117,
-0.023054931,
-0.008432889,
-0.013057599,
-0.0005364903,
-0.0131468,
0.02253345,
0.022478558,
0.015466016,
0.03589982,
-0.028091336,
0.01128731,
-0.014615179,
-0.037711278,
0.0020773453,
0.018375328,
-0.016001219,
-0.004429154,
0.009372927,
0.0067346473,
-0.0052353903,
0.01696184,
-0.02032402,
0.023892043,
-0.006477338,
0.02180612,
0.010669767,
0.006600846,
0.010450196,
0.025497654,
-0.020776885,
0.01720886,
-0.024413524,
0.027528685,
0.022506004,
-0.023000037,
0.035707697,
-0.016358022,
-0.011699005,
-0.008329966,
-0.0041272445,
0.014779857,
0.036860444,
-0.01301643,
-0.0057534403,
-0.008666184,
0.013236,
-0.04147143,
0.010889337,
-0.012597873,
-0.011163801,
0.023631305,
0.019253612,
0.006171997,
-0.013819235,
0.03875424,
-0.023603857,
-0.02072199,
0.010189456,
0.005187359,
0.016632486,
-0.0001046928,
-0.0066454466,
-0.016042389,
-0.024495864,
0.007938855,
-0.009510159,
-0.0027394884,
0.01565814,
0.054343764,
0.017359814,
0.041938018,
0.019582968,
0.0034102085,
0.009530744,
-0.01513666,
-0.013805512,
-0.0026022566,
0.0018406205,
0.0072115273,
0.0067758164,
0.012378302,
0.0073418976,
0.004096367,
0.009276865,
0.021161133,
0.020474974,
-0.009647391,
-0.012433195,
-0.025003621,
-0.020159341,
0.009709145,
0.018800747,
-0.005266268,
0.019143825,
-0.03655853,
0.0014160599,
-0.010717798,
0.010086532,
-0.0026897418,
0.01271452,
0.016454084,
-0.014436778,
0.02050242,
-0.021723783,
-0.010717798,
-0.011486296,
-0.019610414,
-0.03658598,
-0.0019469751,
0.019020317,
-0.012247932,
0.028653985,
0.0148347495,
-0.0052559753,
0.0066900468,
0.0007680688,
-0.020516144,
-0.0053657605,
0.00052791333,
-0.022121755,
-0.020118171,
-0.025319254,
-0.024166508,
-0.028736325,
0.007238974,
0.0052010827,
-0.010505089,
0.012844889,
-0.027185606,
-0.02006328,
0.018787025,
-0.0020653375,
0.03576259,
0.002157969,
0.024344908,
0.017853849,
-0.0143407155,
-0.025099684,
0.0041066594,
0.0075408835,
0.009407235,
0.007705562,
0.011836236,
-0.03628407,
-0.0033072848,
-0.0014400755,
-0.021504212,
0.0011518889,
-0.031179048,
-0.00035015534,
0.015466016,
-0.0020224527,
-0.0031889223,
-0.022739297,
-0.042185035,
0.03019098,
-0.0064670453,
-0.012186178,
0.015301337,
-0.014999428,
0.02607403,
0.040318683,
-0.005859795,
0.013688865,
-0.020296574,
-0.0027789425,
0.021476766,
-0.01648153,
-0.030355658,
-0.0027789425,
0.0071223266,
0.034006022,
0.004710479,
-0.014519117,
0.008117257,
0.009105326,
0.009448404,
0.0148210265,
-0.031673085,
0.032194562,
-0.009736591,
0.007877101,
0.005029543,
-0.020269126,
0.014711241,
0.011253002,
-0.009764037,
-0.028901001,
-0.024125338,
-0.017359814,
0.030465445,
-0.0005497846,
-0.016714824,
-0.0061994432,
-0.013531049,
0.004696756,
0.004830557,
-0.03521366,
-0.011150078,
-0.026389662,
-0.0027240498,
-0.0046350015,
-0.017812679,
0.034225594,
0.0121107,
-0.008782831,
-0.002797812,
0.00082467694,
-0.013894713,
0.0109373685,
0.030849693,
-0.006710632,
-0.031206496,
0.013352647,
-0.019226165,
-0.033457097,
0.007383067,
0.0026314184,
-0.0578569,
-0.02607403,
0.0094895745,
0.009750314,
-0.0034016315,
-0.008775969,
-0.015218999,
0.01712652,
0.008487782,
-0.014409332,
0.0025799565,
0.012330271,
-0.012261655,
0.004099798,
0.023782259,
0.0099493,
0.028187398,
-0.025977965,
0.017483322,
0.006322952,
-0.04460031,
0.0085015055,
-0.016330576,
0.018855639,
-0.011472573,
0.006666031,
-0.017071627,
-0.0065665385,
-0.0138672665,
0.028379522,
-0.012096977,
-0.028736325,
0.014656349,
-0.024591926,
0.0099493,
-0.015109213,
-0.04048336,
-0.021257196,
-0.010127702,
0.00519079,
-0.045945182,
-0.015754202,
-0.010333549,
0.051571682,
0.023192162,
-0.008727938,
-0.028955895,
-0.02223154,
-0.051654022,
-0.0109373685,
0.0051324666,
0.00185949,
0.0029161742,
0.020200511,
0.009517021,
0.014546563,
0.0047036177,
-0.016426638,
-0.014162314,
-0.0050398353,
0.0010506804,
0.0003044829,
0.01453284,
0.004566386,
-0.018622346,
0.0003499409,
0.0024015552,
-0.021559104,
-0.021312088,
0.011829375,
0.0038562117,
0.0012976975,
0.00037845937,
0.012570427,
0.0028098198,
-0.024331186,
0.007966302,
-0.01479358,
-0.002331224,
-0.0016390615,
-0.015644418,
-0.0010043647,
-0.0067449394,
0.0027429191,
-0.015603248,
-0.003360462,
-0.021613996,
-0.010285518,
0.002115084,
-0.01807342,
0.025182022,
0.0080623645,
0.033402205,
0.033292416,
-0.014258376,
-0.000020222918,
-0.0032935615,
0.008824,
-0.007238974,
-0.016975565,
0.02006328,
-0.004679602,
-0.013915298,
-0.010360995,
-0.0012342279,
0.0124126095,
0.0020704838,
-0.017497046,
0.002725765,
-0.021037623,
0.0123988865,
-0.012687073,
-0.005725994,
0.001435787,
0.0005309153,
-0.0008761388,
0.00562307,
-0.006367552,
0.02802272,
-0.010889337,
0.015232722,
-0.0008559829,
0.0011681851,
0.009722868,
-0.006741509,
-0.019404566,
-0.0087348,
0.02470171,
0.21023901,
0.0005497846,
-0.009777761,
0.029312698,
0.0129066445,
-0.01811459,
0.04325544,
0.030520337,
0.010347272,
0.011328479,
0.0165227,
0.005671101,
0.0035611633,
0.010264933,
0.010312964,
0.0028406968,
-0.028434414,
-0.032798383,
-0.0018663515,
0.0026520032,
-0.01829299,
0.0030654138,
-0.018375328,
-0.034143254,
0.025621165,
0.020996455,
-0.016467808,
0.009043571,
0.007238974,
0.0018509129,
0.005458392,
-0.01985743,
0.0058495025,
0.005791179,
-0.0009391796,
-0.018704684,
0.005341745,
-0.027473792,
0.0013002707,
0.02396066,
0.017250028,
-0.010134563,
-0.0017737201,
-0.020969009,
0.012954676,
-0.002274616,
-0.011870544,
0.010923645,
0.0011930583,
0.008769107,
-0.010100256,
-0.01145885,
-0.0024907559,
0.027103266,
-0.009743453,
0.014587733,
0.0165227,
-0.008755384,
-0.006432737,
0.029889071,
-0.01911638,
0.0076506687,
0.0046693096,
0.019075211,
-0.0042576143,
0.0014923951,
0.0025096252,
0.013702588,
-0.007835932,
-0.01487592,
-0.014285823,
-0.008117257,
-0.017044181,
0.005173636,
-0.032880723,
-0.014038806,
0.018457668,
0.012824305,
0.016714824,
0.021298364,
-0.040236343,
-0.027967826,
-0.0063949986,
0.010237487,
-0.0008263923,
-0.0031889223,
0.022629512,
-0.011843098,
-0.015315061,
-0.013345785,
0.015493462,
0.017853849,
-0.0020567605,
-0.004360538,
0.0035097015,
-0.00002652164,
0.013510464,
-0.00830252,
-0.016591316,
-0.01280372,
-0.031535853,
0.07498342,
0.02114741,
-0.011362787,
0.011733313,
0.0006578546,
0.017702892,
0.014724964,
-0.008151565,
-0.0037292722,
-0.00856326,
-0.05459078,
0.01712652,
-0.014683795,
0.026773911,
-0.0056196395,
0.0038596424,
-0.031014372,
0.0018491975,
-0.008281935,
0.0066900468,
-0.0013946175,
0.02892845,
0.012618458,
-0.0018817901,
0.011788205,
0.003928258,
0.00025773834,
-0.0044977698,
0.006525369,
0.010498228,
-0.027501239,
-0.012645904,
-0.012639042,
0.00088257156,
-0.022890253,
0.0053829146,
-0.016124729,
-0.0043571074,
-0.006309229,
0.0070125414,
-0.017661724,
-0.0065802615,
-0.014889643,
0.0080417795,
-0.016165897,
0.0056813937,
0.042322267,
-0.0048545725,
-0.020488698,
-0.011932299,
0.02028285,
0.0026091184,
0.0018835055,
0.011019708,
-0.026581787,
-0.009914992,
-0.016934395,
0.012247932,
-0.00047001868,
-0.01811459,
0.002905882,
0.04369458,
0.0006458468,
-0.014450501,
-0.0013483018,
-0.17510769,
0.010203179,
0.039330613,
-0.009263142,
0.009420958,
0.0025816718,
0.038177866,
0.019994663,
-0.032441583,
-0.010800137,
0.0021099378,
-0.008364274,
-0.022245264,
-0.0014495101,
-0.008089811,
0.007938855,
-0.018320436,
0.014670072,
0.014889643,
0.0002390834,
0.04108718,
-0.008549537,
-0.009201388,
0.00545153,
0.015534632,
0.010717798,
0.007485991,
0.032331795,
-0.013249723,
-0.017620554,
-0.0012385164,
-0.006504784,
0.031426065,
-0.010765829,
-0.02058476,
0.013585941,
0.0071978043,
0.009585637,
-0.013702588,
0.015164106,
0.01919872,
0.014217207,
0.0035234247,
0.0174696,
0.0031631913,
0.022245264,
0.017455876,
-0.00067843933,
0.0008478348,
-0.014738687,
0.002612549,
-0.01453284,
0.026787633,
0.0041581215,
-0.019912325,
-0.011012847,
0.017099073,
0.024248846,
0.0019847138,
-0.029724393,
-0.01487592,
-0.013565357,
0.01569931,
-0.018224373,
-0.016385468,
-0.03628407,
-0.032469027,
0.014601456,
-0.032112226,
-0.009619944,
-0.031041818,
0.006504784,
-0.008775969,
-0.018443944,
0.033319864,
0.041718446,
-0.0047379253,
-0.010738383,
0.0018389052,
0.0031151602,
-0.01025121,
0.027761979,
-0.011520604,
0.011561773,
-0.009798345,
-0.00015610109,
-0.00013487306,
0.0128860595,
0.0063606906,
-0.0064121527,
0.018526284,
-0.025579995,
0.0014074829,
-0.047784086,
0.017648,
0.0073213126,
0.0035989021,
-0.017895017,
0.017716616,
0.0037807343,
-0.003260969,
-0.0054892693,
-0.033155184,
0.017785233,
0.017236305,
-0.018896809,
0.0020464682,
0.0035011244,
0.023727367,
-0.013236,
-0.0001474169,
-0.011060878,
0.010367857,
-0.00026845958,
0.007794762,
0.025923073,
-0.0030654138,
-0.0056162085,
-0.00086799066,
0.0037944573,
0.0653223,
0.0042953533,
-0.018306714,
0.016426638,
-0.0026056874,
0.0014537986,
-0.11988564,
-0.00363321,
-0.003732703,
0.012851751,
0.0060656425,
0.03559791,
-0.018745854,
0.00415126,
-0.024015553,
0.049622994,
-0.02408417,
-0.010861891,
-0.015932605,
-0.014477948,
0.033319864,
0.007115465,
0.021559104,
-0.018196927,
-0.008782831,
0.039248273,
0.009064156,
-0.030163534,
0.0026074029,
-0.011699005,
0.013043876,
0.022670683,
-0.022368772,
0.023480348,
0.009791484,
0.0069816643,
0.017318644,
-0.012680212,
0.002725765,
-0.013153661,
-0.0066626007,
-0.015946327,
-0.032084778,
-0.004164983,
0.005729425,
-0.011966607,
-0.003122022,
0.017291198,
-0.013503602,
-0.023013761,
-0.0054172226,
0.008419166,
-0.016165897,
0.029724393,
-0.0038939503,
-0.007643807,
-0.021078793,
-0.00063984294,
-0.017332368,
0.035405785,
-0.013716311,
0.0029144587,
-0.012193039,
0.010182594,
-0.006847863,
0.0007912267,
-0.015218999,
0.0024101322,
-0.051626578,
0.01301643,
0.024852667,
0.0055819005,
0.005403499,
0.0076575307,
0.008487782,
-0.03611939,
-0.020776885,
0.014752411,
-0.020186787,
0.0109579535,
-0.01038158,
-0.0067003393,
-0.03524111,
-0.031590745,
0.0028132505,
-0.018045973,
-0.000057358575,
-0.01137651,
0.020035833,
-0.014985705,
0.009414096,
-0.009324896,
-0.013716311,
-0.0020361757,
0.008899477,
-0.019582968,
0.02080433,
0.01682461,
0.039550185,
-0.0153287845,
0.009757176,
-0.010244349,
-0.028008996,
-0.0187733,
0.013476156,
-0.0085152285,
-0.021641444,
0.007252697,
-0.055167153,
0.024646819,
0.011403956,
-0.010340411,
-0.01915755,
-0.0095032975,
-0.0056299316,
-0.0055064233,
-0.007335036,
0.0021905615,
-0.009887546,
0.024989897,
-0.016412916,
-0.006254336,
-0.034280486,
-0.027473792,
0.024591926,
0.0061582737,
0.010422749,
0.01587771,
-0.005763733,
-0.009510159,
0.024646819,
0.026046582,
-0.010306103,
-0.014326992,
-0.010230625,
0.012481226,
-0.020831777,
0.0032403842,
0.018210651,
-0.010656044,
-0.02024168,
0.006847863,
-0.009043571,
-0.05769222,
0.01919872,
0.030437998,
0.044435635,
-0.0025010484,
0.0029384743,
-0.023864597,
-0.021394426,
-0.0018406205,
-0.009215111,
0.005822056,
-0.011959746,
-0.005050128,
0.0051496206,
-0.015836542,
0.024056721,
0.002067053,
0.0032403842,
-0.039385505,
-0.011170663,
0.022780467,
-0.0076094996,
0.006899325,
0.002789235,
-0.014162314,
0.015246445,
-0.005777456,
0.0065185074,
0.007643807,
-0.013332062,
-0.014971982,
-0.008892616,
0.027309114,
-0.013510464,
-0.018485114,
-0.0035371478,
0.02076316,
0.0012205046,
-0.007218389,
-0.011136355,
-0.0051702056,
0.015260168,
0.01993977,
-0.0056813937,
0.026828803,
0.006086227,
0.0071840812,
-0.0053520375,
0.017236305,
0.018320436,
0.012700796,
-0.037738726,
0.00175142,
0.0024169937,
0.0026657262,
-0.0055853315,
0.011500019,
-0.0038424884,
0.000060306913,
0.016083559,
0.031069264,
-0.00938665,
0.0061171046,
0.029779285,
0.017044181,
0.0057808864,
0.009832653,
0.010065948,
-0.025717227,
-0.029669499,
-0.014917089,
-0.027858041,
0.008727938,
0.023425456,
0.014971982,
0.010573705,
-0.0059249797,
-0.00903671,
-0.0058186254,
0.013037015,
0.011342202,
0.003749857,
-0.016207067,
-0.024207678,
-0.0074036517,
0.001253955,
-0.0011227271,
0.018059695,
0.002470171,
0.016659932,
0.033319864,
-0.002871574,
-0.026760187,
0.032112226,
-0.0013946175,
0.012707658,
0.026869973,
-0.010354134,
-0.015109213,
0.013510464,
0.0015112645,
-0.011012847,
0.013688865,
0.021998247,
0.060107496,
0.00041019422,
0.016797164,
-0.006319521,
-0.026526893,
0.02693859,
0.028901001,
-0.01851256,
-0.013050738,
-0.035131324,
0.005341745,
0.01180879,
-0.001981283,
-0.021833569,
-0.010422749,
0.009626806,
-0.01630313,
0.028901001,
-0.007945717,
-0.018087141,
0.0057843174,
-0.00795944,
0.016646208,
0.012872336,
-0.006535661,
-0.011108909,
0.020831777,
0.0016510693,
0.0029316128,
-0.013091907,
-0.001526703,
0.033731557,
-0.01543857,
-0.0059592878,
0.00030062324,
-0.011314756,
-0.006274921,
-0.007002249,
-0.0016021804,
0.021202302,
-0.008775969,
-0.0032867,
-0.004676171,
0.013517326,
-0.0076987,
0.0014786719,
0.0012642473,
-0.032084778,
-0.022080585
] |
OBJECTIVE To evaluate the effectiveness of integrated care for chronic physical diseases and depression in reducing disability and improving quality of life. DESIGN A randomised controlled trial of multi-condition collaborative care for depression and poorly controlled diabetes and/or risk factors for coronary heart disease compared with usual care among middle aged and elderly people SETTING Fourteen primary care clinics in Seattle, Washington. PARTICIPANTS Patients with diabetes or coronary heart disease, or both, and blood pressure above 140/90 mm Hg, low density lipoprotein concentration >3.37 mmol/L, or glycated haemoglobin 8.5% or higher, and
|
[
-0.020232372,
0.0022156106,
0.03022252,
-0.027118012,
-0.022036701,
0.034972154,
-0.0031111417,
0.0003922095,
-0.034627207,
-0.019250603,
-0.029453026,
0.042481348,
0.010215689,
0.015960356,
-0.028391656,
0.014209095,
0.04667376,
-0.022461249,
0.011887347,
-0.009306891,
-0.027144546,
0.034972154,
-0.0008474379,
-0.019648617,
-0.009439562,
0.008676702,
0.013247228,
-0.02953263,
-0.0039967224,
-0.021877496,
0.017685084,
-0.004388103,
-0.0033134655,
-0.025671894,
-0.011151022,
-0.008152651,
-0.00984421,
0.0021210823,
0.01853418,
-0.024650326,
0.017313603,
-0.021731557,
0.0019734853,
0.01127706,
0.007907209,
0.007867407,
0.02208977,
-0.027728299,
-0.010580535,
0.014142759,
0.016305301,
0.03109815,
-0.0023665242,
0.013413067,
0.024172708,
-0.0077148355,
-0.009048182,
0.014408102,
0.0010240566,
-0.008530764,
-0.015695013,
-0.005131062,
-0.023443017,
0.0021559084,
-0.024331914,
0.008490963,
0.0016650247,
0.009578867,
0.036856085,
0.0045970604,
0.048637293,
0.035741646,
0.006852472,
0.017910624,
0.010779542,
-0.008670068,
-0.0006368222,
-0.02240818,
0.029585697,
0.013824348,
0.008617001,
-0.014845917,
-0.013811082,
0.01423563,
0.012570605,
-0.0022819461,
-0.0013872442,
0.0038342003,
0.0066600987,
0.006626931,
-0.01875972,
0.012716543,
0.018494377,
0.011980218,
-0.012776245,
0.012039919,
0.009671737,
0.014660178,
-0.0021691755,
-0.025035072,
-0.0052438327,
-0.002845799,
-0.027860971,
-0.020948797,
-0.023443017,
-0.028179381,
-0.020948797,
-0.003053098,
0.0131609915,
0.005419622,
-0.00774137,
0.053174652,
-0.027051676,
-0.023960436,
0.013970287,
-0.032371793,
-0.017658548,
-0.009121151,
-0.001849106,
-0.020365043,
0.010540734,
0.0030431477,
0.028948875,
-0.0049619065,
0.005210665,
0.0058408533,
-0.036113124,
0.011622005,
-0.0033184406,
-0.0019850943,
-0.021307008,
0.010945382,
0.009479363,
-0.0055821445,
-0.03659074,
0.0065904465,
-0.018786255,
0.0019287089,
-0.044259142,
-0.02878967,
-0.020152768,
0.023230743,
-0.006202383,
-0.030063314,
-0.010414696,
0.026401587,
0.037678648,
0.009293624,
-0.016849253,
-0.012955352,
0.006169215,
-0.021784626,
-0.00984421,
0.017247267,
0.024106374,
-0.0064445077,
-0.0029685202,
0.03308822,
-0.0143683,
-0.0073698903,
-0.016583912,
-0.01704826,
-0.008650168,
0.0074892943,
0.0061028795,
0.0029005262,
-0.008630267,
-0.016610445,
0.0026484507,
0.005990109,
0.0065141604,
0.050255883,
-0.019171001,
0.028126314,
-0.000483421,
-0.0002661718,
0.0026534258,
0.013154359,
-0.027197614,
-0.024968736,
-0.022328578,
0.020537516,
0.012013385,
0.019860892,
-0.005346653,
-0.0011111221,
0.013041588,
-0.005608679,
0.01222566,
-0.0136253415,
0.013864149,
0.019860892,
-0.010036583,
-0.01922407,
-0.6313031,
-0.02097533,
0.027051676,
-0.022925599,
-0.008497596,
0.032371793,
0.02592397,
0.00896858,
-0.017738152,
0.015124527,
0.026096443,
0.01829537,
-0.011316861,
-0.0017761369,
-0.012146057,
-0.008464429,
0.0019154417,
-0.02337668,
0.008882343,
-0.012013385,
-0.0210682,
0.019104665,
-0.00096103764,
-0.010016683,
-0.00090713997,
0.009751339,
0.016995192,
-0.011383196,
0.0005045655,
0.026919005,
-0.011847546,
0.015854219,
0.0111443885,
0.023323612,
0.048212748,
-0.030514397,
-0.012351697,
0.003993406,
0.017127864,
0.027091477,
-0.027516026,
-0.0063781724,
0.014434637,
0.0053997217,
0.0037512807,
0.009704905,
0.009492631,
0.002179126,
0.008776206,
0.012743077,
0.0068657394,
0.013147725,
-0.022899065,
-0.021200873,
0.011980218,
-0.021081468,
0.011071419,
-0.0070713796,
0.007734736,
0.010991816,
-0.0055821445,
0.014222362,
-0.023748161,
-0.025711697,
-0.023827763,
0.017313603,
0.008305223,
-0.0008428773,
0.022288777,
0.013300297,
0.026215848,
0.006477676,
-0.0024991955,
0.009326791,
0.060975723,
0.00025891632,
0.02804671,
0.02823245,
-0.027675232,
0.007270387,
0.012716543,
-0.015350068,
0.02084266,
0.0068790065,
0.02555249,
0.012099622,
-0.0062819854,
-0.003489255,
0.009260456,
-0.021877496,
0.012563971,
0.0039668716,
-0.022447983,
-0.017393205,
-0.003747964,
0.031867642,
-0.0055522933,
-0.00497849,
0.030673603,
-0.031443097,
-0.015217397,
-0.0029121349,
-0.007661767,
0.0035754913,
0.00032276436,
0.007913843,
-0.022394914,
0.0022404864,
0.041711852,
-0.013486037,
-0.012219026,
-0.023655292,
-0.0239339,
0.008981846,
0.026242381,
-0.025021804,
0.0018093047,
-0.012663474,
-0.0035091557,
-0.023695093,
0.021731557,
-0.021850962,
0.034733344,
-0.004762899,
-0.015721548,
0.006683316,
-0.014859185,
-0.010779542,
-0.015323534,
-0.015323534,
0.0026998608,
0.0026816186,
0.027860971,
-0.007449493,
0.0116087375,
0.015814418,
0.019927228,
-0.011469433,
-0.01079281,
-0.03406999,
-0.008961946,
0.0012852531,
0.02380123,
0.0070912805,
0.011018351,
-0.0150581915,
-0.013141091,
-0.010845878,
-0.012491002,
-0.01548274,
-0.004049791,
-0.03414959,
-0.026932271,
0.010593803,
-0.023947168,
-0.028179381,
-0.00019195877,
-0.034202658,
-0.020670187,
-0.017565679,
0.03401692,
0.008902243,
-0.02642812,
-0.028365122,
-0.014660178,
-0.03298208,
-0.0051841307,
0.041791458,
-0.018043295,
-0.03091241,
-0.013824348,
-0.017340137,
0.001941976,
0.0069984104,
-0.017114596,
0.01853418,
-0.007893941,
-0.026321983,
-0.0019303673,
-0.00011577643,
0.006258768,
0.010686672,
-0.019210802,
0.004338351,
0.021559084,
-0.024225777,
0.025207546,
-0.003311807,
-0.012398132,
0.012265461,
-0.013260496,
0.033008616,
0.009519165,
0.031443097,
-0.014527506,
0.023018468,
-0.0072173183,
-0.0037147962,
0.008371558,
0.003129384,
0.03720103,
-0.03290248,
0.023098072,
-0.018932194,
0.027701765,
0.00009172976,
0.0070846467,
-0.010341727,
0.036749948,
-0.0017413107,
-0.0029187684,
-0.0060730283,
-0.00850423,
0.008073048,
-0.011628639,
0.017738152,
0.0012578897,
0.019940495,
-0.028179381,
0.0048988876,
-0.0002446127,
-0.0075821644,
0.01635837,
-0.016053226,
-0.00066542946,
-0.0021111318,
0.029957177,
0.019661885,
0.016066493,
-0.0021575668,
-0.0070116776,
0.0013806106,
0.011741409,
0.02462379,
0.008033247,
0.013366632,
-0.006185799,
-0.01793716,
0.035582438,
0.026560793,
0.021240674,
0.02462379,
0.01613283,
-0.0000013587794,
-0.012855848,
-0.01464691,
0.022209173,
0.020829393,
-0.009466097,
0.027569095,
-0.010593803,
0.018481111,
-0.006092929,
-0.015217397,
-0.0032454715,
0.0029453025,
0.009200754,
-0.0093599595,
0.046355348,
0.031496163,
0.022129571,
0.031018548,
-0.011641906,
0.016849253,
-0.006467725,
-0.0031360176,
0.0037081626,
0.0046998803,
0.000860705,
-0.00420568,
-0.01492552,
0.0021111318,
0.009804408,
-0.031204287,
-0.0068126707,
0.028126314,
-0.0033532667,
-0.009373226,
0.027993642,
-0.0018474477,
-0.018149432,
-0.023535887,
0.015588877,
-0.0048789866,
-0.0062521347,
0.0018225719,
-0.00822562,
0.015031657,
-0.00017444202,
0.015442939,
0.008073048,
0.01501839,
0.016636979,
0.0019054913,
0.0073035546,
0.004175829,
0.02181116,
-0.00021745653,
-0.0095656,
0.012325163,
0.002056405,
0.0030464644,
0.009791141,
-0.031628836,
0.026467923,
0.002764538,
-0.01862705,
-0.009147685,
-0.0031310425,
-0.008039881,
0.0025804567,
-0.00072015636,
-0.0016816086,
-0.0051741805,
0.028391656,
0.0018093047,
-0.0123052625,
-0.009273723,
0.0087032365,
-0.017459542,
-0.013267129,
-0.034998685,
0.00010624068,
-0.0101360865,
0.06951976,
0.015496006,
0.0031691855,
0.012238926,
0.015628679,
0.006733068,
0.009499264,
-0.02430538,
0.021386612,
0.03988099,
0.034388397,
-0.022567386,
0.0124313,
-0.0019701687,
0.009386494,
0.022845997,
0.0029055013,
-0.01903833,
0.015363336,
0.0071509825,
-0.0048723533,
-0.011190823,
0.025074873,
0.029055012,
0.043144703,
-0.019383276,
0.01797696,
0.0096319355,
0.013094656,
-0.0076484997,
-0.015535808,
0.027436422,
0.013784547,
0.034441467,
-0.03881962,
-0.0025207545,
0.0066634156,
0.009114518,
0.036192726,
-0.006530744,
0.035794713,
-0.0052935844,
0.0073698903,
0.00850423,
0.004248798,
-0.025008539,
0.006325104,
0.031177754,
-0.015522541,
-0.020895729,
0.043410044,
0.00077820005,
0.0016882422,
-0.03406999,
0.018414775,
-0.0034461368,
-0.015283733,
-0.009247188,
-0.017724885,
-0.024477853,
-0.004620278,
-0.021731557,
0.014315232,
-0.012583871,
-0.022660255,
0.00081717223,
-0.013824348,
0.00984421,
-0.008517497,
-0.007893941,
0.01081271,
-0.018547446,
-0.0027247367,
0.02985104,
-0.0101758875,
0.0010953674,
0.023907367,
-0.00534997,
0.010016683,
0.01922407,
-0.017844288,
-0.0017910624,
0.020311974,
-0.011622005,
-0.0062388675,
-0.0048491354,
0.0054892744,
-0.00852413,
0.00044071744,
0.026627127,
-0.008928778,
0.0024361766,
0.014567307,
-0.018680118,
-0.0106800385,
0.0016210773,
0.0239339,
0.004281966,
-0.013313564,
-0.03308822,
0.004908838,
-0.016278768,
-0.0068060374,
-0.027569095,
0.018175967,
-0.0026683514,
-0.017990228,
-0.004049791,
0.010394796,
-0.036060058,
0.025406552,
-0.028948875,
-0.00036380955,
0.017539145,
0.032584067,
0.022540852,
-0.0087032365,
0.007542363,
0.017486077,
-0.014673444,
-0.0016500992,
-0.011230624,
0.018016761,
-0.0072438526,
-0.030700136,
0.024384983,
-0.0026302084,
-0.026998607,
-0.04075662,
-0.011549036,
0.012351697,
0.03950951,
-0.0040332074,
-0.024995271,
-0.03483948,
-0.0052571,
-0.014408102,
0.016703315,
-0.0016136146,
-0.02629545,
-0.0022122937,
-0.013452869,
0.0043184506,
-0.019980296,
0.041764922,
-0.03003678,
-0.004991757,
-0.0046733464,
-0.013313564,
0.030567465,
-0.0016235649,
-0.019860892,
-0.009048182,
0.021651955,
-0.042614017,
-0.016504308,
0.00718415,
-0.011290327,
0.032743275,
0.011469433,
0.02642812,
-0.004082959,
-0.015695013,
-0.00066667324,
0.016398171,
-0.008510863,
0.013094656,
0.011622005,
-0.009897279,
0.016835988,
-0.005903872,
0.0073168217,
-0.007986812,
-0.011787844,
0.0046633957,
-0.0031409927,
-0.011635272,
-0.025380017,
-0.024225777,
-0.056411833,
-0.026321983,
-0.018414775,
-0.0027977058,
-0.001933684,
-0.046143074,
-0.018892393,
0.023761429,
0.028073246,
0.012729811,
-0.0007288629,
0.01349267,
-0.0112969605,
0.025977038,
0.023363413,
-0.0136253415,
-0.018481111,
-0.0032703474,
-0.021134537,
0.004918788,
0.03022252,
0.020073166,
0.009353326,
-0.011907248,
-0.0006231405,
-0.005767884,
0.015005123,
-0.050706968,
-0.0009958638,
-0.019277139,
-0.038846154,
0.0296653,
-0.0069519756,
-0.009194121,
-0.022726592,
-0.01069994,
0.013154359,
-0.018096363,
0.017234001,
-0.013983554,
-0.0086236335,
-0.014607109,
-0.019953761,
0.010394796,
-0.014806116,
0.024477853,
0.014898986,
-0.0065241107,
-0.0029237436,
0.016782919,
-0.00612278,
-0.0012985202,
0.029559163,
0.025406552,
-0.018971995,
-0.0042852825,
0.0021575668,
0.013207427,
-0.0130813895,
-0.024610525,
0.004066375,
0.029267287,
-0.0063018864,
-0.0043151337,
-0.0017678449,
-0.017247267,
0.014248896,
-0.009539066,
-0.019993564,
0.0064312406,
-0.013943752,
-0.012053187,
0.01760548,
-0.03590085,
0.036060058,
0.008490963,
-0.007874041,
0.00062562805,
-0.0027462956,
-0.011177557,
0.015973624,
-0.0023350148,
0.012656841,
-0.001475968,
-0.009857477,
0.0032703474,
0.005074677,
0.021373345,
0.0058872886,
-0.023681825,
0.035104822,
-0.0006948659,
-0.009015014,
0.029187683,
-0.027250683,
0.0028889172,
0.0057479837,
-0.008099582,
0.0050149746,
-0.03656421,
-0.009068083,
0.008126116,
0.0150581915,
-0.03054093,
0.016849253,
-0.005240516,
-0.0047330484,
0.019210802,
-0.021041667,
0.0050315587,
-0.032079916,
-0.004056425,
-0.018175967,
-0.009572234,
0.016292034,
0.014434637,
0.020590585,
0.008875709,
-0.0006322616,
-0.023045003,
0.013253862,
0.012391498,
0.008404726,
0.0008922144,
0.016942123,
-0.032663673,
-0.024093106,
0.0015771299,
-0.0011525819,
-0.028763136,
-0.025817834,
-0.003870685,
-0.015217397,
-0.008165918,
-0.006776186,
0.015854219,
0.011741409,
0.0093201585,
-0.008311857,
-0.018932194,
0.016716583,
-0.025313683,
0.020869194,
0.039801385,
0.0016741458,
0.016119562,
-0.020272173,
0.034123056,
0.018308638,
-0.027993642,
-0.013691677,
-0.02435845,
0.020166036,
-0.020789592,
0.017777953,
-0.027091477,
-0.0035390067,
-0.0054428396,
0.01959555,
0.005761251,
-0.009147685,
-0.026441388,
-0.0018341806,
-0.00037624748,
0.022341846,
0.00082587876,
-0.018308638,
-0.02222244,
0.009220655,
-0.023960436,
-0.003777815,
-0.013890684,
0.027277216,
0.0055821445,
-0.01025549,
-0.024292113,
-0.023005202,
-0.052988913,
-0.0036584109,
0.0040995427,
0.026507724,
0.013373266,
0.0031907444,
0.0009262114,
0.024703395,
0.011522502,
0.0145142395,
-0.019423077,
-0.02060385,
-0.00036919932,
-0.011495967,
0.011880714,
-0.011920515,
-0.020139502,
-0.005024925,
0.010494299,
-0.005121112,
-0.014275431,
0.0016086394,
0.00210284,
-0.0071974173,
0.01737994,
-0.008796106,
-0.029240752,
-0.014845917,
-0.006991777,
-0.026083175,
0.004461072,
0.0064445077,
-0.0022139521,
0.0017728201,
-0.013134458,
0.011223991,
-0.014421369,
0.0016277109,
-0.023681825,
-0.022023434,
-0.013758013,
-0.033565838,
-0.0053864545,
0.0013267129,
0.014381568,
0.019237338,
0.0052206153,
0.01649104,
-0.0181627,
0.009107884,
0.007867407,
-0.023283811,
0.017711617,
0.007615332,
-0.020855926,
-0.015283733,
-0.0034925716,
-0.0015364994,
-0.026719999,
-0.038740017,
0.012046553,
-0.0115689365,
0.00995698,
-0.0011550694,
-0.019184269,
-0.007860774,
-0.012716543,
-0.012026653,
-0.00850423,
-0.021665221,
0.008942045,
-0.018865857,
-0.008013346,
0.00718415,
-0.0069320747,
0.009731439,
0.010447864,
-0.011927149,
0.0074362257,
0.026361786,
0.22437368,
-0.015190863,
-0.0101360865,
0.016703315,
-0.006626931,
0.018401507,
0.013154359,
-0.0015821052,
-0.016185896,
0.046779897,
0.012550704,
-0.01483265,
0.0012114547,
0.0037446471,
0.0021011815,
-0.0071509825,
0.011476067,
-0.013758013,
0.004248798,
-0.026746532,
-0.01862705,
0.00020014709,
0.02222244,
0.006703217,
0.009884011,
0.008272055,
0.0035290562,
0.011588837,
0.03396385,
0.002386425,
-0.009963614,
0.013930486,
-0.0018457894,
0.02218264,
0.024438052,
-0.019794557,
0.0044245874,
-0.025459621,
0.013306931,
0.00063972437,
-0.008510863,
-0.011071419,
-0.046594158,
-0.0047960673,
0.0055124923,
0.023947168,
0.004371519,
-0.014938788,
0.010023316,
0.0012885699,
-0.03494562,
-0.019277139,
0.01464691,
0.028710067,
-0.012491002,
0.0048192847,
0.012875749,
-0.00306139,
0.0135855405,
0.001704826,
-0.0038342003,
0.0025771398,
-0.0064378744,
0.028312054,
-0.010295292,
0.01728707,
-0.008723137,
-0.0038242498,
-0.014845917,
0.00688564,
0.01691559,
-0.021890763,
-0.0067131673,
0.009220655,
-0.004421271,
-0.012875749,
0.041605715,
0.022753127,
0.02291233,
0.036272332,
-0.017393205,
-0.0015025024,
-0.019436345,
0.0037446471,
-0.03470681,
-0.028285518,
0.013704944,
-0.009499264,
-0.028524328,
-0.009068083,
-0.0025804567,
-0.002963545,
-0.008550664,
-0.010825978,
0.031947248,
0.02337668,
-0.010971916,
-0.009300257,
0.0013275421,
-0.012709909,
-0.0016044934,
0.09260456,
-0.016039958,
0.0052504665,
-0.007681668,
-0.015854219,
-0.0061493143,
-0.0113367615,
0.014779582,
0.004646812,
0.0056285793,
-0.041473046,
-0.00079395476,
-0.030434795,
-0.009870744,
0.02878967,
0.04463062,
-0.020112967,
-0.007270387,
-0.02642812,
0.016305301,
-0.010666772,
-0.00811285,
0.032663673,
-0.019980296,
0.004192413,
0.0017313603,
-0.011257159,
-0.0048524523,
-0.019436345,
0.0015456205,
-0.01280278,
0.017552411,
-0.010248858,
-0.015376602,
0.03494562,
0.013253862,
0.008026613,
-0.008869076,
0.015721548,
-0.004202363,
-0.019847626,
-0.016292034,
-0.0075158286,
0.005495908,
-0.026122976,
0.01235833,
-0.00025207546,
-0.006703217,
-0.012683376,
-0.009260456,
-0.010109552,
-0.007708202,
-0.002565531,
0.026719999,
-0.014620376,
0.0012388182,
-0.029320356,
-0.010892313,
0.0011136096,
-0.028126314,
0.004053108,
0.021837695,
-0.0048988876,
-0.012139423,
0.026534257,
-0.16759038,
0.019436345,
0.013903951,
-0.025977038,
0.027967108,
-0.0072239516,
-0.009094617,
0.0051542795,
-0.0034992052,
-0.00496854,
-0.0013690019,
0.014673444,
-0.03141656,
0.008809374,
0.014978589,
0.024504388,
-0.020139502,
0.0334597,
0.007476027,
0.010242224,
0.012862481,
-0.019489413,
-0.0051575964,
-0.033565838,
0.015177595,
-0.0021857596,
-0.023774695,
0.022434715,
-0.011787844,
-0.0044444883,
0.0071974173,
0.008955312,
0.051317256,
0.0006438703,
-0.018985262,
-0.0030497813,
0.012597139,
-0.0018806155,
-0.0043847864,
0.0048226016,
0.038235866,
0.008026613,
-0.010607069,
0.008630267,
-0.00013256764,
0.03656421,
0.01788409,
-0.020365043,
0.0014734805,
0.013061488,
-0.000595777,
-0.012842581,
0.022593921,
0.004855769,
-0.0010232273,
0.011675074,
0.003519106,
0.007323455,
-0.012610406,
-0.005363237,
-0.011151022,
-0.018918926,
-0.0057380334,
0.012418033,
0.03889922,
-0.03868695,
-0.0031774773,
-0.007893941,
0.004046474,
0.019967029,
-0.031575765,
-0.0063118367,
0.020033365,
0.0061327303,
0.019184269,
0.01797696,
-0.005124429,
0.0073831575,
0.002701519,
-0.0043184506,
-0.0020099701,
-0.0046401783,
-0.016371638,
-0.025764765,
0.00037997885,
0.006457775,
0.019117933,
-0.0018325222,
0.00085158384,
-0.00018884928,
0.01012282,
-0.049061842,
0.018242301,
0.004995074,
-0.0121128885,
0.024995271,
0.002815948,
0.0016550743,
0.0036948954,
-0.009200754,
0.013015053,
-0.006905541,
-0.0063748555,
0.0074362257,
0.0065904465,
0.010447864,
-0.01635837,
-0.00718415,
0.024345182,
-0.009141052,
-0.01185418,
0.015177595,
0.007920476,
0.0382624,
-0.0020978649,
0.019104665,
0.0006766236,
-0.025074873,
0.0022156106,
-0.0027943891,
0.05346653,
-0.0046633957,
-0.024318647,
0.0037811317,
0.010335093,
-0.017724885,
-0.1174937,
0.00755563,
0.011323495,
-0.00007924,
0.012862481,
0.029744903,
-0.010036583,
-0.0033350245,
-0.0055257594,
0.020404844,
-0.003412969,
-0.0024577356,
-0.0072305854,
-0.014248896,
0.03887269,
-0.022049969,
-0.017194198,
-0.0411281,
-0.008683336,
0.035051756,
-0.011190823,
-0.021744825,
0.0042156302,
-0.025525955,
-0.002306822,
-0.0014850893,
-0.019237338,
0.016703315,
-0.006136047,
0.034680273,
0.012398132,
0.017565679,
0.0038176163,
0.0017512611,
-0.018719919,
-0.020816125,
-0.0086634355,
-0.008272055,
0.028126314,
-0.02560556,
0.013021687,
0.00583422,
0.014036623,
-0.018122898,
0.006182482,
-0.0056551136,
0.004998391,
-0.011522502,
-0.009718172,
0.0013615391,
-0.02190403,
0.00017496027,
-0.027277216,
0.012769612,
0.016345102,
-0.016185896,
0.016146095,
0.0007686643,
-0.009897279,
-0.0074362257,
-0.014063157,
0.00794701,
-0.008185819,
0.032875944,
0.015774617,
-0.032637138,
-0.015748082,
-0.011356662,
0.0043085003,
-0.027303752,
-0.0026434755,
0.010129453,
-0.0155623425,
-0.0013913901,
-0.028524328,
0.0020630385,
-0.027250683,
-0.045081705,
0.007708202,
-0.0072173183,
-0.02735682,
-0.0045108236,
0.0353967,
-0.0093201585,
0.014394835,
-0.008059781,
0.0034660373,
-0.007847507,
0.007157616,
-0.011442899,
0.030195985,
0.036988754,
0.018467844,
-0.0070912805,
0.022540852,
-0.0011807745,
0.0025456303,
-0.023761429,
-0.0018175967,
0.017592212,
-0.006474359,
-0.0019436344,
-0.05097231,
0.026083175,
-0.00059121643,
-0.002429543,
0.018282104,
-0.0030033463,
-0.002777805,
0.0036849452,
0.012066454,
0.006918808,
-0.023655292,
0.026441388,
0.01012282,
0.011721509,
-0.027595628,
-0.03146963,
0.023018468,
0.011403098,
0.024982003,
0.021943832,
-0.012053187,
0.009028281,
-0.00053856254,
0.047655527,
0.00059494784,
-0.0015447913,
-0.01483265,
0.038501207,
-0.009340059,
-0.017658548,
0.0030282221,
-0.013054855,
-0.000640139,
0.028816205,
0.0037280633,
-0.022036701,
0.0035854415,
0.035608973,
0.012020019,
0.016199164,
-0.00070440164,
-0.012948718,
-0.005117795,
-0.023190942,
-0.012258827,
-0.0029668617,
-0.043781526,
0.021877496,
-0.022156106,
-0.01004985,
0.0033482916,
-0.00021662733,
-0.006670049,
-0.026945539,
-0.009970248,
0.012643574,
0.0054892744,
0.01747281,
-0.023443017,
-0.02445132,
0.021837695,
-0.02208977,
0.005177497,
0.012769612,
0.0049420055,
-0.0136651425,
-0.0059370403,
-0.00089304365,
0.0027579044,
-0.0123848645,
-0.016530843,
0.0007997591,
-0.010952015,
0.00896858,
0.0009552333,
-0.011469433,
-0.0022968717,
0.015880754,
0.004142661,
0.022607189,
0.007920476,
0.022527585,
-0.034547605,
0.027834436,
0.027197614,
-0.0011492651,
-0.008311857,
0.040623948,
-0.004749632,
-0.0019685102,
0.016238965,
0.017366672,
-0.0021940514,
0.013068122,
0.018282104,
0.040464744,
0.015005123,
-0.01367841,
0.007263753,
-0.0016633663,
0.009048182,
0.009651836,
-0.02291233,
-0.038793083,
-0.0045307246,
-0.0010779542,
-0.01769835,
-0.028630463,
-0.016411439,
0.02384103,
0.007694935,
0.0051874476,
-0.013638608,
0.0047761663,
0.00043657146,
0.0060133263,
-0.0020298706,
0.0044245874,
-0.027967108,
0.009930446,
-0.015867487,
0.012265461,
0.01224556,
0.019436345,
0.016199164,
0.013572273,
0.0043217675,
-0.0024361766,
0.01885259,
0.021612152,
0.015880754,
-0.01071984,
-0.01935674,
-0.016013425,
-0.00659708,
-0.0382624,
0.009479363,
-0.008948678,
-0.00032463006,
0.06315153,
-0.0009262114,
-0.015655212,
0.0039502876,
-0.019303672,
0.00005125465,
-0.012895649,
0.006898907,
-0.01806983,
-0.011827646,
0.0032919063,
-0.005744667,
-0.0072902874,
-0.05203368,
-0.014726513,
0.018640317,
0.0052172984,
0.022368379,
0.015522541,
-0.010706573,
0.0036617275,
-0.0050912607,
0.0021890763,
-0.0063649053,
-0.031867642,
-0.015588877,
0.020391578,
0.0029154515,
-0.023403216,
-0.02116107,
-0.0062388675,
-0.0052902675,
-0.019502679,
-0.019184269,
0.035370167,
-0.00032297167,
-0.000970988,
-0.016902322,
0.0038142996,
0.00206138,
-0.011071419,
0.016597178,
-0.03868695,
-0.015310267,
-0.014978589,
-0.019237338,
-0.0024444684,
-0.022010166,
-0.023363413
] |
BACKGROUND Data on absolute risks of outcomes and patterns of drug use in cost-effectiveness analyses are often based on randomised clinical trials (RCTs). The objective of this study was to evaluate the external validity of published cost-effectiveness studies by comparing the data used in these studies (typically based on RCTs) to observational data from actual clinical practice. Selective Cox-2 inhibitors (coxibs) were used as an example. METHODS AND FINDINGS The UK General Practice Research Database (GPRD) was used to estimate the exposure characteristics and individual probabilities of upper gastrointestinal (GI) events during current exposure to nonsteroidal anti-inflammatory drugs
|
[
-0.0054125516,
-0.00041886838,
0.0180105,
-0.04072173,
-0.00397883,
0.03696115,
-0.0020229917,
0.0012305833,
-0.004328027,
-0.012927,
-0.007883791,
0.016291378,
0.0060236463,
0.012678533,
-0.014908021,
0.03183064,
0.050687272,
0.01427678,
-0.0069772224,
0.0034197792,
-0.0060908,
0.03123969,
-0.029681735,
-0.013578387,
0.00044782824,
-0.001197846,
0.01354481,
-0.03491969,
-0.015485539,
-0.021663638,
-0.0027314583,
0.010375177,
-0.015754152,
-0.019501302,
0.009717075,
-0.003193137,
0.0054864204,
0.01549897,
0.0033794872,
0.022482907,
0.0045899246,
-0.013511233,
-0.011865979,
0.010804958,
0.015122912,
0.0014135758,
0.038975745,
0.00041005452,
-0.01116087,
0.010046126,
0.009361163,
0.014169335,
-0.008447879,
0.007158536,
0.020334003,
-0.008105397,
0.003251896,
0.0077226236,
0.007850215,
-0.013625394,
-0.022791812,
0.019487873,
-0.027062759,
-0.0022949623,
-0.022926118,
-0.01510948,
-0.0053655445,
-0.006453427,
0.0036732827,
-0.00094014546,
0.03161575,
0.038331073,
-0.0110467095,
-0.006581018,
0.041258957,
-0.0011340504,
-0.022456046,
-0.00723912,
0.0076017478,
0.014894591,
0.008864229,
-0.011946563,
0.004784669,
0.00656423,
0.012759117,
0.013739554,
0.0035020418,
0.03204553,
-0.007924084,
-0.007950945,
0.009629776,
0.007588317,
-0.004056056,
0.016089918,
0.0031595603,
0.021730792,
-0.020078821,
0.026982175,
-0.007232405,
-0.03868027,
0.0052849604,
-0.0020867873,
-0.014397657,
-0.014773714,
-0.024255753,
0.007118244,
-0.016801743,
0.0020112398,
0.000076596676,
0.0050062747,
-0.0011516782,
0.03384524,
-0.005701311,
0.008313572,
0.01611678,
-0.009260433,
0.03330801,
-0.0074540107,
0.002625692,
-0.015673568,
-0.007319704,
0.0055905078,
0.025088454,
-0.010704228,
0.014317072,
-0.004774596,
-0.021596484,
0.011154154,
0.010475907,
0.001492481,
-0.007850215,
0.009730506,
0.026122613,
0.015028897,
-0.039539833,
0.037149176,
-0.005231238,
-0.0014102182,
-0.019877361,
-0.0335229,
-0.0045294864,
0.01841342,
-0.0072928425,
-0.0013153643,
-0.012658387,
0.026713561,
0.03679998,
0.027559692,
0.009710359,
-0.010220724,
0.012114446,
-0.026458379,
0.00755474,
0.0068160547,
-0.005140581,
-0.012846416,
0.010972841,
0.035994142,
-0.0005821347,
-0.020951813,
0.0029799254,
-0.020374296,
0.003522188,
-0.0035960565,
0.0027364949,
0.000063008636,
-0.0078300685,
-0.0030621882,
0.0017375903,
0.00066607626,
-0.00019516413,
0.03226042,
-0.013719409,
0.024698965,
0.021891959,
0.006235179,
-0.013994737,
0.026552394,
-0.023611082,
-0.020965245,
-0.018252254,
0.015781013,
0.037901293,
-0.004405253,
-0.009616345,
-0.00733985,
0.018023932,
0.008629193,
-0.015216926,
-0.037122317,
0.007628609,
0.018534297,
-0.004197078,
-0.018252254,
-0.6515477,
-0.025142176,
0.011395906,
-0.018695464,
0.027962612,
0.046631217,
0.021596484,
0.004415326,
-0.016385393,
0.041366402,
-0.002258028,
0.02170393,
0.039110053,
-0.019044662,
-0.015216926,
-0.020951813,
-0.0005305107,
-0.018440282,
0.034597352,
-0.0065407264,
-0.015324371,
0.022778383,
-0.0001806842,
0.015230357,
0.006963792,
0.034167573,
-0.007816638,
-0.033415455,
0.015754152,
0.014773714,
-0.023020133,
0.018776048,
0.004324669,
0.033173703,
0.056247562,
-0.039781585,
-0.014424518,
0.010798242,
0.011570505,
0.03126655,
-0.019353567,
-0.0050767856,
0.022563491,
0.013094883,
-0.024443783,
0.0077159083,
0.017043494,
0.017634442,
-0.0115503585,
0.016815173,
-0.016371962,
0.0017678093,
-0.020750353,
-0.0016687582,
0.021126412,
0.015163204,
-0.0057516755,
-0.01324262,
0.0026978818,
0.020642908,
-0.008038244,
0.0038713848,
-0.024940716,
-0.03800874,
-0.012651672,
0.01252408,
-0.004324669,
0.011140724,
-0.0073331348,
-0.008044959,
0.035053995,
0.018238822,
-0.008642623,
-0.019098384,
0.022926118,
0.013148606,
0.020750353,
-0.0021421886,
-0.028231226,
-0.0010551454,
0.0034886112,
0.021690499,
-0.02790889,
0.03328115,
0.03763268,
0.0009510579,
-0.012745687,
-0.011503351,
-0.0005762588,
-0.03859969,
0.02460495,
0.009428316,
-0.02338276,
-0.016009334,
0.000027805641,
0.03244845,
-0.0016981377,
0.018708894,
0.025101883,
-0.029278817,
-0.030541297,
0.006842916,
-0.0020313857,
0.011704811,
-0.012530796,
0.0154721085,
-0.013269482,
0.010267732,
0.034892827,
-0.034892827,
0.0034986841,
-0.0022529915,
0.004375034,
-0.010663936,
0.015794445,
-0.034489907,
0.0033962755,
-0.012745687,
-0.0165197,
-0.03244845,
0.02976232,
-0.002249634,
0.018655172,
0.009817805,
0.0113488985,
-0.010637075,
-0.00930744,
-0.0032065676,
0.02193225,
-0.016291378,
0.025088454,
-0.024927286,
0.017795611,
0.003968757,
0.023194732,
-0.006534011,
0.018238822,
-0.008212842,
-0.015028897,
-0.029439984,
-0.027210496,
-0.0021505828,
0.010831819,
0.0007793974,
0.0027868599,
-0.016210794,
-0.0012767512,
0.013450796,
0.014625978,
0.0112817455,
0.015458678,
-0.02314101,
-0.001740948,
0.0033156916,
-0.0033778083,
-0.016801743,
-0.013417219,
-0.019662471,
-0.010623644,
-0.019192398,
0.016036196,
0.009696929,
0.009025397,
-0.0033173705,
-0.00890452,
-0.006335909,
-0.014357365,
0.020562325,
-0.0034785382,
-0.04133954,
-0.0012759117,
-0.016667437,
-0.003310655,
0.031105384,
-0.003201531,
0.01960875,
-0.006154595,
-0.013833569,
0.004465691,
-0.01272554,
0.012208461,
-0.009347732,
-0.012550942,
0.004126567,
0.027143342,
-0.009569338,
0.0012868241,
0.0048283185,
-0.0028305093,
0.003740436,
-0.006775763,
0.005738245,
-0.024886994,
0.024524366,
-0.011966709,
-0.01674802,
0.019487873,
0.01798364,
0.004744377,
0.026095752,
0.034221295,
-0.0009863133,
0.021032397,
0.0026945241,
0.023906557,
0.0020364223,
0.016882326,
-0.0058087558,
0.027129913,
0.002726422,
-0.00013692967,
0.01065722,
-0.012785979,
-0.0022647432,
-0.0044623334,
0.01106014,
0.0018769333,
0.0043515307,
0.01446481,
-0.017728457,
-0.012248753,
0.002516568,
0.0421991,
0.015028897,
-0.003918392,
0.0021002179,
0.0058792667,
0.011644374,
0.013477657,
-0.013383643,
-0.020777214,
0.012262183,
0.011362329,
-0.003569195,
0.033630345,
0.017621012,
-0.009817805,
-0.024349768,
0.01841342,
0.008783645,
0.0054629166,
0.0013195613,
-0.010838534,
0.00206832,
-0.004992844,
-0.0078300685,
0.020011667,
0.013638824,
0.0033778083,
0.010321454,
0.006624668,
0.014317072,
-0.015888458,
-0.0063392664,
0.021354733,
-0.021059258,
0.02793575,
0.037525237,
0.032341003,
0.027559692,
0.010596783,
0.0034197792,
-0.009918535,
-0.007487587,
0.00418029,
0.011899555,
-0.02749254,
0.0013539774,
-0.008696346,
-0.010368462,
-0.007709193,
-0.032931954,
-0.0017845975,
-0.005358829,
0.004015764,
0.020844368,
0.011228023,
0.0070309453,
0.018507436,
0.020307142,
-0.017688166,
-0.02667327,
0.026216628,
0.015042327,
0.010119994,
-0.01924612,
-0.008414302,
-0.012678533,
-0.0052748877,
0.023046995,
-0.0022395607,
0.004401895,
0.012074154,
-0.0116510885,
0.008313572,
-0.003827735,
0.029628012,
-0.017312108,
-0.018131377,
-0.0045194137,
0.01198014,
-0.03765954,
0.002724743,
-0.023046995,
0.02440349,
0.004734304,
-0.010482622,
-0.019716194,
-0.0023386118,
0.0063224784,
0.021529332,
0.0040023336,
-0.0071249595,
0.0024712395,
-0.0012683569,
0.0040459833,
-0.020226559,
-0.01169138,
0.023772249,
-0.01529751,
0.00423737,
-0.03140086,
-0.012886709,
-0.0146797,
0.0243632,
-0.009287294,
-0.0039150342,
0.024792979,
0.018990938,
-0.022348601,
-0.017862763,
-0.026606116,
0.0070040836,
0.024282614,
0.0053353254,
0.010784811,
-0.002605546,
0.008743353,
0.0029413123,
0.010261016,
-0.008897806,
-0.02605546,
-0.0058826245,
0.009918535,
0.0001713457,
0.013732839,
0.040453117,
0.027452247,
0.014357365,
-0.026136044,
0.022805244,
0.022241157,
0.013779846,
0.004764523,
-0.018359698,
0.0035389762,
-0.012718826,
0.0067153247,
-0.012806124,
-0.015458678,
0.0053554717,
-0.016613714,
0.013578387,
-0.012853132,
0.009542476,
-0.0048316764,
0.011664519,
-0.005009632,
-0.00407956,
-0.03615531,
-0.0019608748,
0.014317072,
-0.008219558,
-0.020320572,
-0.011469775,
0.0065978067,
0.0027818233,
-0.027720861,
0.026176335,
-0.024752688,
-0.0059094857,
-0.008266564,
-0.019058092,
-0.029332539,
-0.023893125,
-0.0005166603,
0.005580435,
-0.012315906,
-0.012383059,
-0.005190946,
-0.03722976,
-0.020132544,
0.002227809,
-0.0044119684,
-0.005311822,
-0.018064223,
-0.010247585,
0.02396028,
0.0079979515,
0.0010190505,
0.02871473,
0.010475907,
-0.010831819,
0.0075950325,
-0.0038948883,
-0.0021589769,
-0.006423208,
-0.040668007,
0.0005535946,
0.0034281733,
-0.01944758,
-0.008306857,
-0.012329336,
0.03038013,
0.0119197015,
-0.009300725,
0.020951813,
-0.01842685,
0.002417517,
0.007903937,
0.007527879,
0.0146662695,
0.004015764,
-0.02522276,
0.007286127,
-0.0046872967,
-0.0063224784,
-0.030004071,
-0.006896639,
0.0040929904,
-0.025464512,
0.002117006,
0.009844666,
-0.02892962,
0.010355031,
-0.041446984,
-0.018091084,
-0.013188898,
0.0042440854,
0.021609915,
-0.00203978,
0.030917356,
0.021341302,
-0.027170204,
-0.0062284637,
0.022388892,
0.016277947,
-0.004066129,
-0.02400057,
0.01613021,
-0.026821008,
-0.01631824,
-0.037713263,
-0.009972258,
0.019702762,
0.033979543,
0.0043145963,
-0.025719695,
-0.010475907,
0.011006418,
-0.02687473,
0.025155606,
-0.014706561,
-0.0103416005,
0.011127293,
-0.009515615,
-0.0073264195,
-0.0078032073,
0.033791516,
-0.026001738,
-0.0002281112,
0.013061306,
-0.021556193,
-0.0061411643,
0.01529751,
-0.0042910925,
-0.008286711,
-0.00091664185,
-0.027559692,
-0.030648742,
-0.007064522,
-0.010469192,
0.018990938,
0.028284948,
0.02500787,
-0.009032112,
-0.008293426,
0.02500787,
-0.0053252527,
0.002655911,
-0.0039754724,
0.008367294,
-0.02025342,
0.013793278,
0.008656054,
-0.015391525,
-0.00397883,
-0.010274447,
0.0004528647,
0.0056308,
-0.027586555,
-0.018359698,
-0.012779263,
-0.029010203,
-0.02191882,
0.004005691,
0.0007752003,
-0.003042042,
-0.033388596,
0.0017812399,
0.024014002,
0.013054592,
0.016412254,
-0.012940431,
0.012315906,
-0.015163204,
0.008185981,
0.006194887,
0.00094770023,
-0.03682684,
-0.009555907,
-0.012846416,
0.013699262,
0.01354481,
0.0002549725,
0.029144509,
0.0102408705,
-0.015875028,
-0.011798826,
-0.007091383,
-0.014733423,
0.004892114,
0.0027784656,
-0.020199697,
0.0019272983,
0.00846131,
0.00091580243,
0.0052883183,
0.0028271517,
0.020535463,
-0.00097036443,
0.009985688,
-0.029735459,
-0.013088168,
-0.014840867,
-0.026525533,
0.0405337,
-0.025477942,
0.013430649,
0.037740126,
-0.008548608,
0.0027801446,
0.008555324,
-0.0013934299,
-0.005899413,
0.028016334,
0.03389896,
-0.013665686,
-0.009555907,
-0.009475323,
-0.00656423,
-0.019528164,
-0.020804076,
0.020145975,
0.018776048,
-0.005311822,
-0.009582768,
0.00919328,
-0.043273553,
0.02704933,
-0.0062284637,
0.005358829,
-0.0038143045,
-0.018305976,
-0.01694948,
0.018990938,
-0.02065634,
0.028231226,
-0.004176932,
-0.0018970793,
-0.0054159095,
-0.009743936,
-0.00481153,
0.016909188,
-0.012221891,
0.005885982,
0.02253663,
-0.016089918,
0.022174003,
-0.0051372233,
0.024309475,
-0.003421458,
-0.012383059,
0.039432388,
0.007051091,
-0.018064223,
0.028231226,
-0.014491671,
0.002066641,
-0.0111810155,
-0.013094883,
-0.039566692,
-0.012644957,
0.0014941598,
0.010489337,
0.0285267,
-0.028634144,
0.0154721085,
-0.016210794,
-0.0061915293,
-0.010079702,
-0.015351232,
0.0044925525,
-0.007964375,
-0.018520866,
-0.003411385,
-0.00008950269,
0.024148308,
-0.0001954789,
0.0019071522,
0.008810506,
-0.00868963,
-0.045583624,
-0.007648755,
0.017876195,
0.002358758,
-0.020683201,
0.018923786,
-0.041903626,
-0.017312108,
-0.009287294,
-0.021865098,
-0.046577495,
-0.04730275,
-0.02111298,
-0.0029262027,
-0.006950361,
-0.022509769,
0.0027767867,
0.024578089,
0.0055670044,
-0.0057550333,
-0.0073264195,
-0.0012456927,
-0.014397657,
0.016425684,
0.029654874,
-0.009884958,
0.00962306,
-0.023463344,
0.010066272,
-0.013101598,
-0.01778218,
-0.005667734,
-0.023879696,
0.043730196,
-0.013101598,
0.004039268,
-0.0013497802,
-0.0016393787,
-0.017338969,
0.029037064,
0.011019848,
-0.00336102,
0.008595616,
-0.019084953,
-0.02460495,
0.007883791,
-0.020562325,
-0.009858097,
-0.0163451,
0.010113279,
-0.020736923,
0.009273863,
-0.024631811,
0.054743327,
0.029520568,
-0.020522032,
-0.044133116,
-0.023100717,
-0.038438518,
0.019729624,
-0.011671235,
0.011442914,
0.0015923714,
0.0026710203,
0.024672104,
0.028634144,
-0.014693131,
-0.017218092,
-0.018050794,
-0.015592984,
-0.0042642313,
-0.014773714,
0.034489907,
0.0021321157,
-0.047651947,
-0.01594218,
0.02520933,
-0.02624349,
0.004566421,
0.0074204337,
-0.0024259111,
0.016600283,
-0.009965542,
-0.01510948,
-0.009179849,
0.0040929904,
0.011006418,
-0.03682684,
0.022375463,
0.006386274,
0.00028162394,
-0.0061713834,
0.00604715,
-0.0072726966,
-0.0042642313,
-0.015982473,
-0.013215759,
-0.009938681,
0.0009535761,
0.0025232832,
-0.0053655445,
0.008219558,
0.013296343,
0.008964959,
-0.008004667,
-0.012718826,
-0.030809911,
0.0024997797,
0.024578089,
-0.01549897,
0.006063938,
-0.007380142,
-0.0024007286,
-0.013941014,
-0.008609046,
0.0015352911,
0.002189196,
-0.013323205,
0.019178968,
-0.0035423338,
0.009267149,
0.017043494,
-0.0079979515,
-0.00013671981,
-0.017218092,
0.0073532807,
-0.0068764924,
-0.026350934,
0.016076488,
-0.026015168,
-0.014370795,
0.009690214,
-0.019098384,
0.014155905,
0.0017560574,
-0.015230357,
-0.036450785,
0.029601151,
0.17964837,
0.002734816,
-0.004764523,
0.024537796,
0.0011558753,
-0.006027004,
0.02790889,
0.00018750445,
-0.025343636,
0.028687868,
0.018480575,
0.0057113837,
-0.010999702,
-0.00025854,
0.010475907,
-0.008253134,
-0.03188436,
-0.020562325,
0.0050667124,
0.0050767856,
0.02147561,
0.025786847,
-0.00016882746,
0.0012532475,
0.03223356,
0.0061210184,
-0.004066129,
0.01903123,
0.02170393,
-0.011288461,
0.0032250348,
-0.0063191205,
0.022818673,
0.021260718,
-0.006087442,
0.0065004346,
-0.005899413,
-0.007010799,
0.009139557,
-0.017835902,
0.0009854739,
0.013202328,
-0.022576923,
-0.009220141,
0.002038101,
0.008340433,
-0.00060983544,
-0.021999404,
-0.012403205,
-0.0011306928,
-0.039727863,
-0.008642623,
0.0107780965,
0.0075681712,
-0.009475323,
-0.03309312,
0.034624215,
0.0012910212,
0.010731089,
0.0119197015,
-0.014424518,
0.0014102182,
-0.018883493,
0.006265398,
-0.029950349,
0.0023100718,
-0.023879696,
0.004405253,
-0.009112696,
0.0005208574,
-0.0005661858,
0.00021342142,
-0.015861597,
-0.0012700357,
-0.021327872,
-0.010146855,
0.0042440854,
0.04652377,
0.02997721,
0.021556193,
-0.00445226,
0.0056308,
-0.04606713,
0.003310655,
-0.024739256,
-0.026189767,
0.013766415,
0.008112112,
-0.038116183,
0.019178968,
-0.0076151784,
0.0043380996,
-0.024752688,
-0.035295747,
0.026821008,
0.001113065,
-0.0152034955,
0.005459559,
-0.009079119,
-0.016909188,
-0.03722976,
0.09643207,
-0.022778383,
0.013658971,
0.005647588,
0.006651529,
-0.018843202,
0.018856632,
-0.007823354,
0.02049517,
0.016936049,
-0.015163204,
0.004643647,
-0.023852834,
0.020629479,
0.017621012,
0.012517366,
-0.02191882,
0.005526712,
-0.016412254,
-0.014505101,
-0.002227809,
-0.0016267875,
0.02334247,
-0.006335909,
0.0018635027,
-0.0027012394,
-0.013168752,
-0.008400871,
-0.023852834,
-0.010308024,
-0.024027431,
0.019904222,
-0.0007970251,
-0.005721457,
0.013967875,
0.005509924,
-0.019259552,
-0.012685249,
0.031696334,
0.0077226236,
0.014625978,
0.009072403,
-0.002058247,
0.025598818,
0.022657506,
0.0047779535,
0.009388024,
-0.017432984,
-0.0014102182,
0.0055435007,
-0.012443497,
0.005580435,
-0.013222475,
0.025571957,
-0.0110467095,
0.009361163,
-0.024376629,
0.013323205,
0.024148308,
-0.021583054,
-0.003312334,
0.044186838,
-0.0028808743,
0.0021102908,
0.015592984,
-0.17083786,
0.023194732,
0.022778383,
-0.016439116,
0.017325537,
-0.009737221,
0.04131268,
0.020562325,
-0.0043380996,
-0.0063426243,
0.025034731,
0.005184231,
-0.033549763,
-0.022388892,
0.00071098504,
0.014437948,
-0.027116481,
0.020535463,
0.01944758,
0.038707133,
0.025504803,
0.012020431,
0.016573422,
-0.01858802,
0.014048459,
0.017218092,
-0.013900722,
0.019071523,
-0.013967875,
-0.008729923,
-0.00033010019,
0.02440349,
0.02664641,
-0.006970507,
-0.017674735,
-0.0022731374,
-0.013168752,
0.024081154,
-0.011167585,
0.005838975,
0.0061411643,
0.019957945,
-0.016909188,
0.003962042,
-0.02416174,
0.009636492,
0.028472977,
-0.020011667,
0.014988605,
0.0031494873,
0.004129925,
-0.0072458354,
0.012470358,
-0.0231813,
-0.010798242,
0.0215159,
0.011389191,
0.011127293,
0.006235179,
-0.032609615,
-0.004307881,
-0.030057793,
0.018547727,
0.0014312036,
-0.006550799,
-0.022093419,
-0.011140724,
-0.0155392615,
-0.019313274,
0.002288247,
-0.02871473,
0.011167585,
0.0005225362,
-0.0062922593,
0.035080858,
0.018856632,
-0.0072995583,
-0.008535177,
0.016707728,
-0.0035020418,
0.00012591234,
0.0043683187,
-0.014182766,
-0.01821196,
-0.012289044,
0.015069189,
0.014411087,
0.023302177,
0.004526129,
-0.01116087,
0.037417788,
-0.010731089,
0.025813708,
-0.014505101,
0.011758533,
0.027210496,
0.0122554675,
0.021663638,
-0.004227297,
-0.013497802,
0.022348601,
0.002823794,
-0.010563206,
0.006903354,
0.02604203,
-0.0009586126,
-0.009562623,
0.0019407289,
0.036289614,
0.0049055447,
-0.024900425,
0.007991237,
0.00075085723,
-0.0013909116,
-0.022550061,
0.028419254,
-0.0018651815,
-0.0020616048,
-0.021368163,
-0.047034133,
0.044912092,
0.0069302153,
0.005966566,
0.014102182,
-0.0119197015,
-0.009132842,
-0.1129249,
-0.0326902,
0.03556436,
-0.02892962,
-0.008931382,
0.009347732,
-0.013591818,
0.0016519699,
-0.018265683,
0.040050197,
-0.014531963,
0.0040023336,
-0.0039721145,
-0.019474441,
0.051708,
0.005738245,
0.012577803,
-0.03561808,
-0.0038445233,
0.026955314,
-0.005617369,
-0.00064341206,
0.00785693,
-0.00574496,
-0.0050062747,
-0.012221891,
-0.014746853,
0.023624513,
-0.0016267875,
0.020307142,
0.011154154,
-0.0050297785,
0.01674802,
-0.0033643777,
-0.020078821,
-0.031642612,
0.004939121,
-0.0156064145,
0.017083786,
-0.024913855,
0.028472977,
0.028472977,
0.04077545,
-0.011812257,
-0.010623644,
-0.01354481,
-0.008602331,
0.0115503585,
0.0071786824,
0.009596199,
-0.014814006,
-0.032958813,
-0.0043683187,
0.0012968971,
0.010737805,
-0.0070376606,
-0.0049256906,
-0.0013153643,
-0.0077360542,
-0.009938681,
-0.0071988283,
0.0064299237,
-0.01354481,
0.030004071,
-0.009199995,
-0.0010870432,
-0.018373128,
-0.018117946,
-0.001167627,
-0.027062759,
-0.016828604,
-0.0007105653,
-0.014787145,
0.013994737,
-0.027425386,
0.001288503,
-0.0118189715,
0.0024426994,
0.017903056,
-0.009441746,
-0.012564372,
-0.013000869,
0.006869777,
-0.016036196,
0.0034651076,
0.01716437,
0.0076151784,
-0.0041232095,
-0.0049256906,
-0.0318575,
-0.010402038,
0.031750057,
-0.0023688308,
-0.02563911,
0.014961744,
0.007400288,
0.0036732827,
-0.0039150342,
-0.008145689,
-0.015055758,
-0.017419552,
-0.003362699,
-0.052782454,
0.026001738,
0.017392691,
-0.012947146,
0.0015504006,
0.009065689,
0.032529034,
0.006950361,
-0.004623501,
0.019098384,
-0.05246012,
0.020401157,
-0.0152034955,
0.01610335,
-0.025800278,
-0.024792979,
0.010287877,
0.024725826,
0.017352398,
0.02729108,
0.00455299,
-0.0025417504,
0.0020649624,
0.013658971,
-0.017218092,
0.0020935026,
-0.016210794,
0.017338969,
-0.033549763,
-0.008367294,
0.0020347433,
-0.013611963,
-0.0074540107,
0.0021119697,
-0.0030051079,
-0.008293426,
0.0015378094,
0.038116183,
0.035483778,
0.009931966,
-0.026512103,
-0.017674735,
0.01281284,
-0.019729624,
0.008044959,
-0.026350934,
-0.025894292,
0.021166705,
-0.013350066,
0.00672204,
0.026941882,
-0.0029413123,
0.005499851,
-0.03846538,
-0.015633276,
0.009414885,
0.005053282,
0.0011508388,
-0.025195898,
-0.020038528,
0.040560562,
0.0009376272,
0.0053185374,
0.002007882,
0.0017174443,
-0.009784228,
-0.029735459,
-0.013175467,
0.03704173,
-0.026713561,
-0.040748592,
-0.0106102135,
-0.0180105,
0.01177868,
0.020172836,
-0.009797659,
0.0019373712,
0.009985688,
0.009542476,
0.0198505,
0.021139842,
-0.0063997046,
-0.00765547,
0.00805839,
0.0048518223,
0.0070846677,
-0.025289914,
0.006990653,
-0.0073532807,
0.0073264195,
-0.0037169324,
0.018131377,
-0.02273809,
0.0037840856,
-0.0022445973,
0.025558526,
0.0021455463,
-0.014169335,
0.00015382291,
0.036074724,
0.00034982644,
0.00982452,
-0.006359413,
-0.0310248,
0.008454594,
-0.00065936096,
-0.0143305035,
-0.041635014,
-0.0045597055,
0.036477644,
0.0063426243,
0.0038143045,
-0.0064970767,
-0.012201745,
0.0066380985,
0.0044623334,
0.0010836856,
-0.018896924,
0.0058087558,
0.017862763,
-0.0037706548,
0.023839403,
0.02026685,
-0.017688166,
-0.00027008198,
-0.015015466,
0.028419254,
-0.023006702,
0.029869765,
0.017083786,
-0.00038424248,
-0.006016931,
-0.012738971,
-0.0029983926,
0.0037337206,
-0.034570493,
0.001581459,
0.017526997,
-0.014209627,
0.07053777,
0.012134592,
0.0053957636,
-0.0076890467,
-0.018507436,
0.01570043,
-0.01531094,
0.012960576,
0.0072256895,
-0.042897496,
0.011906271,
0.0017929918,
0.02520933,
-0.041017205,
-0.009978972,
0.020562325,
0.011429483,
-0.008696346,
0.0027432102,
-0.014612547,
0.021032397,
-0.0030370057,
0.008387441,
-0.02790889,
-0.014773714,
-0.017056925,
0.016465977,
-0.012530796,
-0.009656637,
-0.031373996,
-0.009441746,
0.017849334,
-0.017177802,
-0.0076151784,
0.013658971,
-0.021811375,
-0.006154595,
-0.000795766,
0.0070040836,
-0.008944812,
0.0069369306,
0.009065689,
-0.02131444,
-0.03204553,
-0.013457511,
-0.019931084,
-0.022079987,
-0.013101598,
-0.01312846
] |
EBI2, aka GPR183, is a G-couple receptor originally identified in 1993 as one of main genes induced in Burkitt's lymphoma cell line BL41 by Epstein-Barr virus (EBV) infection. After it was reported in 2009 that the receptor played a key role in regulating B cell migration and responses, we initiated an effort in looking for its endogenous ligand. In 2011 we and another group reported the identification of 7α, 25-dihydroxyxcholesterol (7α, 25-OHC), an oxysterol, as the likely physiological
|
[
-0.041275635,
-0.0060452847,
-0.009426316,
-0.025912225,
-0.012962875,
0.02592575,
-0.0146195805,
0.010650249,
-0.019677604,
-0.012658582,
-0.009750895,
-0.013003447,
0.0027775175,
0.013064306,
-0.025709365,
0.021057066,
0.025547074,
0.010001091,
-0.0017767322,
0.03700201,
-0.028265424,
0.01671582,
0.013747275,
-0.033404592,
0.0035500831,
-0.0069987355,
0.0125909615,
-0.032025132,
-0.011055973,
-0.0064915805,
0.0000631302,
0.0017716605,
-0.011306169,
-0.0039794743,
-0.011590176,
-0.028130183,
-0.0023870084,
-0.021665651,
0.035270922,
0.019014921,
0.015295787,
0.009615654,
-0.012746489,
0.01556627,
0.005044499,
0.012793823,
0.00835791,
-0.019866941,
-0.008838017,
0.04600908,
-0.0071339766,
-0.006197431,
0.005237218,
-0.0116510345,
-0.01284792,
-0.001382842,
0.021219354,
0.023559028,
-0.003962569,
-0.027264638,
-0.010318909,
-0.027061777,
-0.026885964,
-0.0034723193,
-0.0007708752,
0.025709365,
0.007593797,
0.020732487,
0.01222581,
0.006099381,
0.02300454,
0.016702296,
-0.003191694,
0.00080214976,
0.030321091,
-0.00855401,
-0.031673502,
-0.018095281,
0.004151907,
0.0030530714,
0.025154876,
-0.004057238,
-0.017135069,
0.02120583,
0.012509817,
-0.019001398,
0.009974043,
0.018054709,
0.012536865,
-0.004459581,
0.0059404727,
0.0209083,
0.013997471,
0.0077966587,
-0.006234622,
0.012313717,
0.007850755,
0.031592358,
0.004899115,
-0.026980633,
-0.012002662,
0.0014174975,
0.005078309,
-0.014132712,
-0.014768346,
-0.017973565,
-0.01641829,
-0.025276592,
0.0075261765,
0.011076259,
-0.03175465,
0.020921823,
0.016080186,
-0.027602741,
0.036001224,
-0.0100822365,
0.011691608,
0.0006322529,
-0.005886376,
-0.016472386,
-0.009088213,
0.023193877,
-0.0011850515,
-0.032944772,
0.019542363,
-0.001157158,
-0.028752293,
-0.021652127,
0.011245311,
0.0006614143,
0.00704607,
-0.004047095,
-0.011421124,
0.014362622,
-0.015390456,
-0.00039980697,
-0.006068952,
-0.019785797,
0.006173764,
-0.024532765,
0.013476792,
0.027886748,
0.00095091516,
-0.009764419,
-0.004943068,
0.011549604,
0.0046827286,
0.0133753605,
0.012902017,
0.006024998,
-0.024884392,
-0.0021942896,
0.036785625,
0.0010236073,
0.011894469,
0.017432598,
-0.0038171846,
0.038787194,
-0.015796179,
-0.018473957,
-0.0010252978,
-0.012009424,
0.012171714,
0.0051019765,
0.02910392,
0.038002796,
-0.015147022,
0.0015265357,
0.0034757005,
-0.011806563,
-0.013368599,
0.018947301,
-0.02028619,
0.00294995,
0.0045272014,
0.0060452847,
0.00026815807,
0.009737371,
-0.0060621896,
0.018473957,
-0.019231308,
0.008202382,
0.026290901,
-0.00943984,
-0.008175334,
0.0023616506,
0.0011360266,
-0.021489836,
-0.013186024,
-0.045386966,
0.0008731514,
0.020610768,
0.008844779,
-0.0023430549,
-0.6270867,
-0.01867682,
0.016283048,
0.013118402,
0.016594103,
0.024695056,
0.021016492,
-0.006498343,
0.0033218635,
0.009358696,
-0.0025611315,
0.019298928,
0.004503534,
-0.014132712,
-0.0065896306,
-0.03500044,
-0.012557152,
-0.010832826,
0.03502749,
-0.010021377,
-0.03297182,
-0.013916326,
-0.014538436,
0.030726815,
0.0006453544,
0.013091355,
0.008432292,
-0.016147807,
0.004036952,
0.026764246,
-0.011725417,
0.035108633,
0.0075532245,
-0.0028941631,
0.04457552,
-0.0066876803,
0.014146236,
0.011678083,
0.01910959,
0.03405375,
-0.0044392943,
-0.0022991016,
0.01858215,
-0.015647415,
-0.020002183,
0.031213684,
0.004483248,
0.03759707,
-0.0014555341,
-0.016377717,
0.006224479,
0.017851846,
-0.040004365,
-0.017932992,
0.01196209,
0.003742802,
0.0047875405,
-0.015106449,
0.012394862,
0.007201597,
0.009182882,
0.022368904,
-0.011691608,
-0.024505718,
-0.01225962,
0.0022737437,
-0.023126256,
0.022071375,
0.018798536,
0.0120161865,
0.028265424,
0.036785625,
-0.004807827,
0.013828419,
0.019163687,
0.019893989,
0.0016034542,
0.023153305,
-0.019582935,
0.012908778,
-0.025912225,
0.0005223694,
-0.01887968,
0.01671582,
0.022571767,
0.0014048186,
-0.02474915,
0.0099469945,
0.007161025,
-0.021949656,
0.020854203,
-0.0043480066,
-0.021192307,
-0.025966322,
-0.016242476,
0.0045542493,
-0.0075532245,
0.014051567,
0.010285098,
-0.016756393,
-0.014403194,
-0.012969637,
-0.005030975,
-0.0140650915,
0.011028925,
0.003326935,
-0.030726815,
-0.008858303,
0.034297183,
-0.02818428,
-0.016391242,
-0.009493937,
-0.014200333,
-0.0029144492,
-0.018933777,
-0.019542363,
0.0069784494,
0.0046455376,
0.005680133,
-0.021936134,
0.020110376,
0.012557152,
0.0016761464,
-0.017351454,
0.0051019765,
0.018149378,
-0.002674396,
-0.011529318,
0.0052203126,
0.0069006854,
0.016675247,
-0.013287454,
0.009534509,
-0.006035141,
0.045414016,
-0.0062582893,
0.029861271,
0.015390456,
0.0015679534,
-0.034621764,
-0.021016492,
-0.014646629,
0.01681049,
-0.0115563655,
-0.0051797405,
-0.0060655707,
0.00839172,
0.007167787,
-0.00062549085,
-0.0142950015,
0.028238377,
-0.004459581,
-0.009216692,
0.016120758,
0.018636245,
-0.012083807,
-0.027643314,
0.0065963925,
-0.013253644,
-0.005477271,
-0.010785491,
0.00085666886,
-0.0116713215,
-0.010548819,
0.0038171846,
0.00020983527,
0.003152812,
0.0278597,
-0.010846349,
-0.029753078,
0.0019474742,
0.007871041,
-0.021084113,
0.017378502,
0.009784705,
0.0063597206,
-0.0037698501,
-0.013071069,
-0.006626822,
-0.0112115005,
-0.0048517804,
-0.007445032,
-0.007871041,
-0.006434103,
0.029185064,
-0.00501407,
0.0010886922,
0.013091355,
0.024884392,
0.0068296837,
-0.016742868,
0.0278597,
-0.01694573,
0.02733226,
-0.00022314809,
-0.028076086,
0.007161025,
0.015187594,
0.0003154925,
0.039301112,
0.015187594,
-0.013213071,
0.011434649,
-0.012577438,
0.006288719,
-0.023626648,
-0.009838802,
-0.019285405,
0.011387315,
0.01091397,
0.008736585,
0.010305384,
0.013524126,
0.001222243,
-0.012083807,
0.009629178,
-0.015309311,
0.014443767,
-0.00062844926,
-0.012097331,
0.015877325,
0.023572553,
0.01671582,
0.011481984,
-0.018555101,
0.003641371,
0.020705437,
0.0056429417,
-0.0030767387,
-0.016688772,
-0.015944945,
-0.0010709418,
0.010237764,
0.002834995,
-0.010663774,
-0.0012974709,
0.023775414,
-0.016066663,
0.031646457,
-0.013172499,
-0.000076707154,
0.022761105,
0.008912399,
0.022193091,
0.0077763726,
-0.01006195,
0.0041586687,
-0.00083722797,
-0.019542363,
0.035325017,
-0.0005050416,
0.022152519,
-0.012509817,
0.009182882,
0.016729344,
-0.0011968851,
0.01740555,
0.026520811,
0.021124685,
0.025776984,
0.021625077,
0.006741777,
-0.0034790814,
-0.010298622,
0.013875754,
0.03175465,
-0.017851846,
-0.011982376,
-0.0058491845,
-0.013300979,
0.0035027487,
-0.009115261,
0.009311361,
-0.032430854,
0.023396738,
0.013632319,
0.026899487,
0.0015307621,
0.002877258,
-0.00087484194,
-0.026399095,
-0.02684539,
0.025763461,
0.03483815,
-0.025100779,
-0.009345171,
-0.009433079,
-0.020380858,
-0.0070257834,
0.00920993,
0.008073904,
0.002870496,
0.016080186,
0.0045677735,
-0.025560599,
-0.010900446,
0.02222014,
-0.03316116,
-0.004036952,
0.0023903893,
0.01593142,
-0.012645058,
-0.0073233144,
-0.0055787023,
0.040274847,
-0.011380552,
-0.0034621763,
-0.022111947,
0.00014369385,
-0.0036007985,
-0.0042634807,
-0.00675192,
-0.009223455,
-0.019231308,
-0.019231308,
0.02523602,
0.014606057,
0.007837231,
0.013233358,
-0.03145712,
-0.023640173,
-0.03359393,
-0.00298207,
-0.015836751,
0.013449743,
0.012962875,
-0.01032567,
0.030158801,
0.0020505956,
0.0032660766,
-0.0071272147,
-0.023640173,
0.013003447,
0.01029186,
0.0087230615,
0.0142950015,
-0.0016499434,
-0.009088213,
0.009919947,
0.009723847,
-0.0042229085,
-0.043114915,
0.020259142,
0.00010132529,
0.021760318,
0.0077019897,
0.011427887,
0.03992322,
0.0038848054,
-0.011380552,
0.0059269485,
0.036731526,
0.005058023,
-0.018284619,
0.0061331913,
-0.012097331,
-0.0027555407,
0.00048729117,
-0.0065017235,
-0.02802199,
0.004706396,
0.011894469,
-0.010569105,
0.001632193,
0.01950179,
0.016851062,
0.0026490383,
0.0073976973,
-0.0006381697,
-0.012983161,
0.007803421,
0.0005608286,
0.023653697,
-0.012969637,
0.024113517,
-0.010298622,
-0.0064679133,
-0.01111007,
-0.013693178,
0.004165431,
-0.0023785557,
-0.011678083,
-0.00966975,
-0.020164473,
0.0017919467,
-0.035189778,
0.005162835,
-0.012969637,
0.023180353,
-0.016134283,
-0.010386529,
-0.036947913,
0.013071069,
-0.031484164,
-0.010460911,
-0.03126778,
-0.02468153,
0.0063631013,
-0.0026405856,
0.011481984,
0.016472386,
0.0038814242,
0.0057883263,
0.008317337,
-0.0130304955,
-0.005595607,
0.002848519,
-0.013557937,
0.0062920996,
-0.0016169783,
0.017716605,
-0.02097592,
-0.004415627,
0.0024749152,
-0.009196406,
-0.009324885,
0.015268738,
-0.01104245,
0.0033015774,
0.029780127,
0.023315594,
0.0025256306,
-0.009453365,
-0.001169837,
0.013916326,
-0.0042093843,
-0.002346436,
-0.0021385024,
-0.0006068952,
0.019582935,
0.01284792,
0.010589391,
-0.014944159,
0.0035128917,
0.004993784,
-0.014727773,
0.00043784358,
-0.0064746756,
0.0071069286,
0.034297183,
0.0026676338,
0.01196209,
0.006511867,
-0.03516273,
0.01055558,
-0.011853897,
0.015174069,
-0.019353025,
-0.015579794,
-0.0020539768,
-0.017973565,
-0.013943374,
0.015539221,
-0.012854682,
-0.005027594,
0.006200812,
-0.0031646455,
-0.013476792,
-0.034270138,
0.009446602,
-0.020380858,
0.021192307,
-0.011590176,
-0.030916153,
-0.014930636,
-0.00040107488,
0.00016197255,
-0.01343622,
-0.0057173246,
-0.030916153,
-0.013334788,
0.018271094,
-0.018541576,
-0.006542296,
-0.008445817,
0.00809419,
-0.006853351,
-0.019893989,
-0.03110549,
-0.046793476,
-0.028887535,
0.00097035605,
0.034270138,
0.030077657,
0.030375188,
-0.014687201,
0.022044325,
0.013240119,
0.008594582,
0.001019381,
-0.022098422,
0.014105664,
-0.024302855,
0.022896346,
0.0023768651,
-0.0071272147,
0.014917111,
-0.01710802,
0.020367334,
0.013902802,
-0.027359307,
0.004709777,
-0.0060452847,
-0.030321091,
-0.015092925,
0.023748366,
-0.012820872,
0.021868512,
-0.020718962,
-0.008432292,
0.025547074,
-0.008567534,
0.021246402,
-0.0126856305,
0.020394383,
-0.028752293,
0.026250329,
-0.012503055,
-0.014700726,
-0.016512958,
-0.021354595,
0.007979235,
-0.0154445525,
0.009926708,
0.004266862,
0.00612981,
-0.00878392,
-0.015552745,
0.017689558,
0.0044494374,
0.0041248584,
0.0044392943,
-0.013557937,
-0.0073300763,
-0.011157405,
-0.025709365,
-0.029996512,
-0.030997297,
-0.00022547254,
0.034567665,
-0.020407906,
0.029239161,
-0.0045677735,
-0.013652606,
0.020556672,
0.00017623627,
0.024208186,
-0.03592008,
0.04151907,
0.026033944,
0.017121544,
-0.01609371,
0.0017234809,
-0.005751135,
0.003759707,
0.017378502,
0.037948698,
0.000571817,
-0.005656466,
0.005267647,
0.02134107,
-0.037488878,
-0.016147807,
0.021070588,
-0.021124685,
-0.008743348,
-0.0060182363,
-0.0145249115,
-0.016228952,
0.003365817,
-0.0013245192,
0.012841158,
0.0064712944,
-0.00393214,
-0.016540006,
0.020624293,
-0.01304402,
0.0038273279,
0.0075667487,
-0.012306955,
-0.019434169,
-0.031808745,
0.006312386,
0.009311361,
0.0034892247,
0.027386356,
0.0070325457,
-0.006812779,
0.004628632,
0.00061661564,
-0.0018730914,
-0.017946515,
-0.0015375242,
0.041464973,
-0.009250502,
-0.009473651,
0.017716605,
-0.019880466,
0.030321091,
-0.008824493,
-0.012624772,
0.00086638937,
-0.026236804,
0.0064645326,
0.015782656,
0.0030243327,
-0.007823708,
0.006112905,
-0.020800106,
-0.018852632,
-0.044521425,
-0.0055043194,
0.019799322,
-0.046577092,
0.00878392,
-0.017892418,
0.015458076,
0.03353983,
0.0026422762,
0.016080186,
0.008445817,
0.014579008,
-0.026453191,
-0.005450223,
0.018514529,
0.017770702,
-0.023072159,
-0.0020134044,
-0.008973258,
-0.025601171,
-0.011427887,
0.00026625625,
-0.01867682,
-0.038651954,
-0.010237764,
0.016283048,
0.0232074,
-0.014592532,
0.024492193,
0.00045094508,
0.011833611,
-0.00022800831,
-0.020137424,
0.014876539,
-0.00008235982,
0.0039355205,
0.0028468287,
-0.023423787,
-0.014579008,
0.004692872,
-0.013470029,
0.004594822,
-0.025195448,
-0.01632362,
-0.010907208,
0.016891634,
-0.008155048,
0.0055279867,
-0.012070282,
-0.014687201,
-0.012022948,
0.0145249115,
0.013598509,
-0.021895561,
-0.017067447,
0.010582629,
-0.0058255172,
0.00419586,
0.008472865,
-0.009378982,
-0.010508246,
-0.03332345,
-0.03562255,
0.016228952,
-0.028590003,
0.022382429,
0.009656226,
-0.022071375,
-0.026074516,
-0.018433385,
-0.057829164,
0.0014411648,
-0.010318909,
-0.0015400599,
-0.01687811,
-0.0005608286,
-0.0069987355,
0.0014699035,
0.00020032612,
0.011644273,
-0.008439055,
-0.022044325,
0.0069852113,
-0.011948566,
0.01858215,
0.023085684,
-0.044007506,
-0.014376147,
0.025993371,
0.0017293977,
0.010812539,
0.030429285,
-0.02772446,
0.021002969,
-0.014754822,
-0.009480412,
0.01133998,
0.017540792,
0.00035564226,
-0.027994942,
0.001524,
0.017513745,
0.011874183,
-0.020313237,
-0.0112115005,
-0.00044756406,
0.00956832,
0.0115766525,
-0.030402236,
-0.010190429,
0.005416413,
0.011725417,
0.024627434,
0.01701335,
-0.0057207053,
-0.0049904026,
0.008533724,
-0.0073368386,
-0.02005628,
-0.006745158,
-0.03002356,
0.005331887,
0.011197977,
0.00048095174,
-0.0015857038,
-0.0079319,
-0.001035441,
-0.019380074,
0.004804446,
-0.016039614,
-0.016377717,
-0.021719746,
0.010758443,
0.013524126,
-0.03919292,
-0.037488878,
0.0032525524,
-0.014795395,
-0.037678216,
-0.0060486654,
-0.007384173,
-0.025384786,
-0.018000612,
-0.00917612,
-0.0013160666,
-0.006437484,
0.000114321134,
-0.0038138037,
-0.0026760865,
0.0017767322,
0.1979932,
-0.0060419035,
0.0070393076,
0.00065761065,
0.0018866156,
-0.028833438,
0.004888972,
0.012347528,
0.0023870084,
0.013713464,
0.0197317,
0.015336359,
-0.026196232,
-0.001235767,
0.013016972,
-0.011116832,
-0.04627956,
-0.0021875275,
-0.008804206,
-0.012942589,
0.0063766255,
0.008797444,
-0.00707988,
-0.029942416,
0.038814243,
0.0054028886,
-0.026196232,
0.0078980895,
0.01248953,
-0.0042026225,
-0.023937704,
0.0049261632,
0.0045508686,
0.007958949,
-0.0073571247,
0.0076276073,
-0.021002969,
-0.0018325191,
0.0069852113,
0.021381645,
0.003955807,
-0.00039832777,
-0.016932206,
-0.014687201,
-0.0046624425,
0.011515793,
0.003536559,
-0.028995726,
-0.011055973,
-0.00096105825,
-0.030537477,
0.013497078,
-0.009541271,
0.017513745,
0.011826849,
-0.02369427,
0.014119188,
0.016621152,
-0.008479627,
0.009926708,
-0.0035602262,
0.01409214,
-0.039301112,
0.028103134,
-0.0029482595,
0.040031414,
-0.01858215,
-0.019785797,
0.012543627,
-0.038381472,
0.021543933,
0.0057173246,
-0.018473957,
0.006417198,
-0.009541271,
-0.0035027487,
0.03332345,
0.004598203,
0.027426928,
0.0029482595,
0.021219354,
0.019907514,
-0.04222232,
-0.0070325457,
-0.019163687,
-0.033052966,
0.016688772,
0.020367334,
-0.03621761,
0.0032474808,
0.023721317,
0.009250502,
-0.0077763726,
-0.0009804992,
0.02615566,
0.009548034,
0.0018629484,
0.0020759534,
-0.0116713215,
0.002398842,
-0.009372219,
0.104135774,
0.014822442,
-0.0046962528,
-0.02831952,
0.01844691,
-0.025601171,
-0.001222243,
0.00002715391,
0.008114476,
-0.0036075606,
-0.03405375,
0.0011258835,
-0.00014210898,
-0.005781564,
-0.0030953344,
0.014835967,
-0.00675192,
0.014470816,
-0.0072083594,
-0.024952013,
-0.030429285,
0.004320958,
0.040220752,
-0.038192134,
0.009094975,
-0.004486629,
-0.012083807,
-0.01222581,
-0.03405375,
-0.013179261,
0.012577438,
0.027778555,
0.0045272014,
0.008283528,
0.0010523461,
0.019555887,
-0.002877258,
-0.019785797,
0.02749455,
-0.0058288984,
-0.010332433,
0.03389146,
-0.0033708885,
0.005859328,
0.0014048186,
0.02323445,
0.016039614,
-0.008709538,
0.0039794743,
-0.021449264,
-0.028941631,
-0.0073976973,
0.009980805,
0.0449001,
-0.02861705,
-0.033404592,
-0.02762979,
0.029455546,
-0.002146955,
-0.022585291,
0.010447388,
0.039977316,
-0.019380074,
-0.0037089917,
0.0067789685,
-0.17191869,
0.012868206,
0.036974963,
-0.030348139,
0.023531979,
0.019069018,
0.010007854,
-0.0005063095,
-0.014700726,
0.012219048,
0.041275635,
0.0065558203,
-0.038110986,
-0.03640695,
-0.017202688,
-0.008215907,
0.0005477271,
0.02484382,
0.02585813,
-0.0010675607,
0.02382951,
-0.026426142,
0.01392985,
-0.019150162,
0.012584199,
0.028211327,
0.0083241,
0.004469724,
-0.014078615,
-0.00439196,
-0.014579008,
0.029239161,
0.037651166,
-0.0002673128,
0.00786428,
-0.00007005075,
-0.008412006,
0.003274529,
0.0020522862,
0.019704653,
0.038165085,
0.021854987,
-0.0025712745,
0.014511388,
-0.03592008,
0.027967893,
-0.0009974043,
0.0006905757,
0.021016492,
-0.01415976,
0.024505718,
-0.009473651,
0.015525697,
0.019637031,
0.02134107,
0.028535906,
0.020854203,
0.02323445,
-0.008912399,
-0.01913664,
-0.013104878,
-0.025127826,
0.038002796,
-0.041113343,
0.016053138,
-0.022896346,
-0.0043040533,
0.0067248717,
-0.041464973,
0.004486629,
-0.02687244,
-0.016255999,
0.0070325457,
-0.022138994,
0.025384786,
0.028454762,
-0.013821657,
-0.00013333943,
0.015201118,
0.0020134044,
-0.0035095108,
0.0077763726,
-0.015850276,
0.007235408,
-0.024113517,
-0.0010988353,
0.006971687,
0.016120758,
0.015187594,
-0.0053995075,
0.033864412,
-0.029617837,
0.017486695,
-0.020610768,
0.0067147287,
0.008087427,
-0.0029313543,
0.0046759667,
-0.013828419,
0.010589391,
0.026629005,
-0.025046682,
-0.0035500831,
0.023572553,
0.026115088,
-0.015417504,
0.00074720796,
0.003952426,
0.062102787,
-0.01071787,
-0.0107516805,
-0.010826063,
-0.0021063827,
0.015742082,
-0.028400665,
0.027305212,
-0.009196406,
0.010433864,
0.017216213,
-0.029753078,
0.034161944,
0.0051898835,
-0.0042465758,
0.001396366,
-0.022463573,
-0.023126256,
-0.11062735,
-0.009892899,
0.02615566,
0.011400838,
0.004040333,
0.024235234,
-0.0062684324,
-0.006931115,
-0.0020083329,
0.025844606,
-0.01595847,
0.0044190083,
0.004730063,
-0.02127345,
0.016310096,
0.027994942,
0.0016414908,
-0.007181311,
-0.016472386,
0.032566097,
-0.009122023,
-0.008141524,
-0.009135547,
0.010738157,
0.025317164,
-0.0014834276,
-0.022233663,
0.018365763,
0.007837231,
-0.0013912945,
-0.0030108087,
-0.026033944,
0.038895387,
-0.002028619,
-0.03821918,
-0.019582935,
-0.0040200464,
-0.01717564,
0.03949045,
-0.01570151,
0.018690342,
0.013618795,
-0.0026963728,
0.0019643793,
-0.013551175,
-0.006427341,
-0.008297051,
0.012793823,
0.02251767,
0.0018494243,
-0.02641262,
-0.02910392,
-0.020867728,
0.00019303577,
0.008919162,
-0.023356166,
0.0033573643,
0.019948086,
-0.018392812,
-0.011414363,
-0.005260885,
-0.0048010647,
-0.008844779,
-0.010907208,
0.014186809,
0.008479627,
-0.0019322595,
-0.013071069,
0.02369427,
-0.010136332,
-0.016228952,
0.0045272014,
0.0028096372,
0.023545504,
-0.028725244,
0.022111947,
-0.0133956475,
-0.010792253,
0.031321876,
-0.041437924,
-0.022463573,
-0.022504147,
0.007411221,
-0.01091397,
0.038841292,
0.002304173,
0.004141764,
0.0033455307,
0.015796179,
-0.041410875,
-0.02454629,
0.031943988,
0.013287454,
-0.032025132,
-0.015038828,
0.0055347485,
-0.005477271,
-0.01701335,
0.0061670016,
-0.00010650249,
-0.018460432,
-0.008790682,
-0.07005498,
0.024438096,
-0.0040200464,
-0.0025408452,
0.02058372,
-0.008209145,
0.021638602,
-0.0011225025,
0.005223694,
0.016634675,
-0.017621936,
0.041600212,
-0.00087568717,
-0.0044291513,
-0.010947781,
-0.023085684,
0.041924793,
0.0045812977,
0.03064567,
0.034594715,
-0.00090273545,
0.017446123,
0.028076086,
0.004993784,
-0.021422217,
-0.012293431,
-0.01756784,
0.01593142,
-0.0247762,
-0.010785491,
-0.012509817,
-0.051337585,
-0.005906662,
0.0011360266,
0.0023785557,
-0.027751507,
0.0032931247,
0.023653697,
0.04579269,
0.017256785,
-0.01910959,
-0.027305212,
0.029049823,
0.0026625623,
0.0059134243,
0.00014316555,
-0.03870605,
0.013456506,
0.0054975576,
-0.0022111947,
0.02454629,
0.00943984,
0.0015231548,
-0.035703693,
-0.0076411315,
0.0044392943,
-0.0075126523,
-0.0011115142,
0.0073436005,
-0.013476792,
0.029509643,
0.020610768,
0.0098523265,
-0.00085159735,
0.021760318,
-0.016201904,
-0.031943988,
-0.014281478,
0.025749937,
-0.040301897,
-0.020489052,
-0.0068296837,
-0.0033421498,
0.032457903,
-0.00091879535,
0.001366782,
-0.016377717,
0.018149378,
-0.008702775,
0.021259926,
-0.0071204524,
-0.012313717,
0.00048095174,
-0.0074247452,
0.02861705,
0.010562343,
-0.0044223894,
0.016675247,
0.013956899,
0.008736585,
0.006407055,
0.028860485,
0.022341857,
0.022409478,
0.006403674,
0.00875011,
-0.011055973,
0.0051831217,
0.008675727,
0.048659805,
-0.007945424,
0.012820872,
0.0113264555,
-0.04579269,
0.00337596,
0.019893989,
-0.024275808,
-0.034567665,
-0.026980633,
-0.0010219167,
0.0070934044,
0.008898875,
-0.025587646,
0.013321265,
0.0013219834,
0.0053149816,
-0.018785011,
0.001222243,
-0.009493937,
0.02831952,
0.008885351,
0.018541576,
-0.028076086,
-0.012178476,
0.015160546,
-0.013456506,
0.042844433,
-0.0021351215,
0.007674942,
-0.035649598,
0.0023058637,
-0.005845804,
-0.001661777,
-0.02127345,
0.0073571247,
0.0031274543,
-0.0038915675,
0.012935827,
-0.023072159,
0.08341681,
0.02120583,
-0.004628632,
0.010393291,
-0.030726815,
0.039842077,
0.013591747,
0.008053618,
-0.025222495,
-0.0340808,
0.012097331,
-0.023572553,
0.015620366,
-0.03540616,
-0.028211327,
0.022842249,
-0.005003927,
0.016512958,
0.00816181,
-0.0049667354,
-0.0072489316,
-0.015255215,
0.009933471,
-0.0041248584,
-0.026629005,
0.0083241,
0.015660938,
-0.002611847,
-0.006116286,
-0.059397962,
0.013814895,
0.0024918204,
-0.044359133,
0.0062751947,
0.008702775,
-0.028887535,
-0.023450835,
-0.030429285,
0.018311666,
0.023680745,
0.0028400666,
0.017310882,
-0.007749324,
-0.019434169,
0.027305212,
-0.0037766122,
-0.041437924,
-0.0046624425,
-0.0024901298
] |
DNA damage can stall the DNA replication machinery, leading to genomic instability. Thus, numerous mechanisms exist to complete genome duplication in the absence of a pristine DNA template, but identification of the enzymes involved remains incomplete. Here, we establish that Primase-Polymerase (PrimPol; CCDC111), an archaeal-eukaryotic primase (AEP) in eukaryotic cells, is involved in chromosomal DNA replication. PrimPol is required for replication fork progression on ultraviolet (UV) light-damaged DNA templates, possibly mediated by its ability to catalyze translesion synthesis (TLS) of these lesions.
|
[
-0.021735935,
-0.012581839,
-0.029465163,
-0.031158872,
-0.03371288,
0.03027169,
-0.006153138,
0.040622137,
-0.008273635,
0.001849974,
0.0115804,
0.0063917357,
0.0042645177,
0.0022834828,
-0.017205935,
-0.005511276,
0.018980296,
-0.01711184,
-0.017138723,
0.017421009,
-0.030110385,
-0.004506476,
0.018805549,
-0.023671601,
0.016453175,
0.009443101,
-0.0028564539,
-0.02184347,
-0.029734006,
-0.009133931,
-0.00029215642,
-0.011842522,
0.006583286,
-0.008455103,
-0.00049609883,
0.0030160793,
0.026628872,
0.010337003,
0.01912816,
-0.013603441,
0.004681224,
0.018886201,
-0.005595289,
-0.001044286,
-0.002019681,
0.011620726,
0.023685044,
0.00016246081,
0.004066246,
0.011325,
0.019625518,
0.015203056,
-0.0054138205,
0.005447426,
-0.012971661,
-0.016722018,
0.008582804,
0.019276023,
0.0013500946,
-0.0064723887,
-0.008172818,
0.004361973,
-0.019208813,
0.0012845641,
-0.0066605783,
0.022192966,
0.013630326,
-0.00078678504,
0.0036360978,
-0.016157448,
0.034062374,
0.023523739,
-0.009402774,
-0.007641854,
0.009100326,
-0.027516052,
-0.013791632,
-0.01422178,
0.0003259718,
0.030809376,
0.022891957,
-0.012924614,
-0.00009887321,
-0.0039923145,
0.00578684,
-0.017972136,
-0.015122403,
-0.01680267,
0.010935178,
0.0056725815,
0.0134085305,
0.03220736,
0.03736914,
0.008024955,
-0.02447813,
0.028336024,
0.007789718,
0.024491573,
-0.024612552,
-0.029734006,
-0.015216499,
0.0028043657,
0.031669673,
-0.004661061,
-0.021628397,
0.015350919,
0.014288991,
-0.009510311,
-0.0014248665,
-0.0039553484,
-0.010894852,
0.01912816,
-0.015915489,
-0.032072935,
0.017837714,
-0.01869801,
0.024531899,
-0.0046106526,
-0.025015816,
-0.012366765,
0.024746973,
0.033874184,
0.0106932195,
-0.030110385,
0.03667015,
0.00020016181,
0.003831009,
0.015135845,
0.0033504525,
0.0033991802,
0.018536706,
0.024007656,
0.031158872,
0.007789718,
-0.018173767,
0.01686988,
-0.02082187,
-0.025271216,
-0.018173767,
-0.035003323,
0.015740741,
0.01762264,
-0.0144099705,
-0.005870853,
0.012682656,
0.01088813,
0.006700905,
-0.0016575834,
0.007964466,
0.019168487,
0.017313471,
0.013993264,
0.0030597663,
-0.01692365,
0.018550148,
0.010303398,
-0.0009812759,
0.015767626,
-0.010753709,
-0.024679761,
0.003619295,
-0.016789228,
0.016264984,
-0.018980296,
0.0043014837,
0.039062846,
-0.011540074,
0.010498309,
0.017488219,
-0.029922195,
-0.021010058,
-0.0012097922,
-0.045945223,
0.013939495,
-0.015633205,
0.016278427,
-0.0048156455,
0.017192492,
-0.008918857,
-0.034250565,
0.006700905,
0.028228486,
0.0056288945,
0.009732107,
-0.02598365,
-0.007782997,
-0.00026380192,
-0.0040124776,
0.0046577,
-0.010189139,
-0.009900133,
0.0006048961,
0.012548234,
-0.010659614,
-0.62930703,
-0.03322896,
-0.019141601,
-0.018402284,
-0.012756587,
0.03755733,
0.005891016,
0.0032412352,
-0.026104629,
0.015740741,
-0.009920296,
-0.010289955,
0.016399406,
-0.021372996,
-0.02731442,
-0.03201917,
0.004919822,
-0.005682663,
0.01869801,
0.0028026854,
-0.035379704,
-0.0046072924,
0.0013484143,
-0.0053533306,
0.01736724,
0.018993739,
0.0357292,
-0.01057224,
0.011721543,
0.019155044,
-0.027556378,
0.024531899,
-0.038982194,
-0.016654806,
0.040057566,
0.016748901,
0.00446951,
0.020284183,
0.010249629,
0.039062846,
-0.0034815134,
0.006902537,
0.0105319135,
0.0011997106,
0.015781067,
0.015754184,
0.017407566,
0.012279391,
-0.0036529005,
0.0055280784,
0.014867003,
0.020095993,
0.00032639186,
0.028793056,
0.018039348,
0.03379353,
0.018993739,
-0.026292818,
0.013495904,
0.00842822,
0.001271122,
0.036213115,
-0.008979347,
-0.020606795,
-0.015700415,
-0.01478635,
-0.03970807,
0.009053279,
0.0017197533,
-0.0001711772,
0.021735935,
0.017783945,
0.0008506352,
-0.01630531,
-0.010995667,
0.014799792,
-0.0011820679,
-0.000114783244,
-0.008347566,
0.017152166,
-0.0045602447,
-0.010168976,
-0.03371288,
0.0038814167,
0.020983174,
-0.017138723,
-0.021426765,
0.009953902,
-0.0130523145,
-0.015310593,
0.026131513,
0.0048862165,
-0.0027640392,
-0.027153116,
-0.039439227,
0.017501662,
-0.00030538853,
-0.0066034496,
-0.01208448,
-0.010740267,
0.0014794751,
-0.028766172,
0.004704748,
0.014961097,
0.0434181,
-0.009570801,
-0.023832908,
-0.00786365,
0.05543537,
-0.0030160793,
0.0007821643,
0.0037806008,
-0.0053398884,
0.0032378745,
0.006388375,
-0.019020623,
0.027717685,
0.009355727,
0.010303398,
-0.020163205,
-0.0045199185,
-0.025244331,
-0.0115871215,
-0.0202573,
0.022542462,
0.021104153,
0.00283125,
-0.019060949,
0.021211691,
-0.0054978337,
0.010841083,
0.002522081,
0.019800266,
-0.015068634,
0.016708575,
0.0134085305,
0.011674495,
-0.010337003,
0.014867003,
-0.017152166,
-0.011392211,
-0.010034555,
-0.010679777,
-0.002354054,
-0.0076351333,
-0.030244807,
-0.04895626,
0.0038578932,
0.018388843,
0.007897255,
0.027771454,
0.011681217,
-0.010552077,
0.027610147,
-0.0018970214,
0.0025187202,
0.0010232826,
-0.04387513,
-0.016278427,
-0.009436379,
0.01522994,
0.011634169,
-0.005595289,
0.006771476,
0.00014271768,
0.0032093101,
0.014047032,
-0.017421009,
0.0017592396,
-0.030540533,
-0.0032933233,
0.010249629,
-0.015579436,
0.003266439,
-0.004069607,
0.042100772,
0.0015408049,
-0.005470949,
0.0091204895,
0.004795482,
-0.0026329784,
0.0003694487,
-0.010404213,
-0.004499755,
0.0087105045,
0.02006911,
0.034465637,
-0.0065597626,
0.008912137,
0.041697506,
0.008891973,
0.03032546,
0.023066705,
-0.012568397,
0.0023641358,
-0.007386454,
0.013045593,
0.02215264,
-0.001271122,
0.04046083,
0.001667665,
-0.033013888,
0.0121046435,
-0.044654775,
0.027556378,
-0.022313947,
-0.000874579,
-0.021480534,
-0.0049534272,
-0.014262106,
-0.020028783,
-0.02252902,
-0.021561187,
-0.0054138205,
-0.012279391,
0.028793056,
0.002819488,
-0.0055011944,
-0.00008039027,
-0.004039362,
-0.006428702,
0.0008048479,
0.011304837,
-0.019208813,
-0.024047982,
0.014208338,
0.0032866022,
0.025647596,
-0.019746497,
-0.010814198,
-0.0035016765,
0.014047032,
-0.0036260162,
0.01365721,
0.005192025,
0.036777686,
0.016641365,
0.015337477,
0.017757062,
0.006815163,
-0.0070571215,
0.017703293,
0.009732107,
0.003915022,
0.010841083,
-0.004449347,
0.027852107,
-0.01120402,
0.0024531898,
0.00887181,
-0.017044628,
0.0043552523,
-0.025849229,
0.020378279,
0.0013038872,
-0.0016012945,
0.0057935608,
0.017703293,
0.061457448,
0.027852107,
0.010968783,
-0.018012462,
-0.0019239058,
-0.00019606616,
-0.011022552,
-0.034492522,
0.010995667,
-0.027663916,
-0.013952937,
-0.018066231,
-0.009053279,
0.008912137,
0.022058545,
-0.041374896,
0.014396528,
0.019961573,
-0.0007073924,
0.02605086,
0.017407566,
-0.005027359,
-0.013952937,
-0.038605817,
0.026776735,
0.022797864,
-0.00962457,
-0.018294748,
-0.021803144,
0.007493991,
0.008542477,
0.015525667,
-0.02787899,
0.023483412,
-0.0010157215,
0.024625994,
-0.010928457,
-0.0314546,
0.024827626,
-0.015888605,
0.027072463,
-0.011526632,
0.006173301,
0.011903011,
-0.021507418,
0.0037100296,
0.04387513,
0.0205127,
0.0021641839,
0.008293798,
-0.0030177596,
-0.03637442,
-0.008650015,
0.012803635,
0.008313961,
-0.011042715,
-0.01893997,
0.002083531,
-0.015391246,
-0.0044627893,
0.011183857,
0.018818991,
-0.000002410461,
-0.03441187,
-0.01051175,
0.007010074,
0.029814659,
0.034761366,
0.0042208307,
0.025432521,
0.008468546,
0.017851157,
0.0007115931,
-0.038928427,
0.009429659,
-0.031347062,
0.00073343655,
-0.005403739,
0.01661448,
-0.0032445956,
0.021561187,
0.021816587,
0.015915489,
-0.015041751,
-0.015189614,
-0.014732582,
0.0018953412,
-0.0024431082,
0.038552046,
0.025755133,
0.010552077,
-0.007191543,
0.015283708,
0.006304362,
-0.0023809383,
0.0035957715,
-0.034492522,
0.01699086,
0.0034781527,
0.0122121805,
-0.013085919,
-0.033013888,
0.012299554,
0.020485817,
0.010343724,
0.011130089,
0.0064354227,
0.009570801,
0.0059279823,
0.009073442,
0.02951893,
-0.024814183,
0.0020348034,
0.020620236,
-0.030674955,
-0.010733546,
0.016385963,
-0.007191543,
-0.032691274,
-0.01553911,
0.012736424,
-0.005645697,
0.010666335,
-0.020042226,
-0.018980296,
-0.007917418,
0.0031219362,
0.0024548701,
-0.012709539,
-0.0019037426,
-0.006576565,
0.0026951483,
0.012702819,
-0.006361491,
-0.016023027,
0.0030043174,
-0.016883323,
-0.0500854,
-0.021951009,
-0.008058561,
0.006700905,
0.0055919285,
0.027905874,
-0.006475749,
-0.0069294213,
0.02636003,
0.001875178,
-0.016641365,
0.015458456,
-0.038955312,
-0.032046054,
0.0089591835,
-0.003951988,
0.010471424,
-0.01289773,
0.0059044585,
0.0062069064,
-0.0038780563,
0.041885696,
-0.02705902,
-0.011734985,
0.03739602,
0.018523263,
0.062694125,
0.010867967,
-0.007843486,
-0.01849638,
-0.042020116,
-0.010115207,
-0.028766172,
0.00057843194,
-0.018066231,
-0.02623905,
0.019047506,
-0.0011896291,
-0.021655282,
-0.0044527077,
-0.02252902,
-0.0005339048,
0.01264233,
0.019410444,
0.020687448,
0.003076569,
0.010780593,
-0.027247211,
0.0014677133,
0.0040360014,
-0.022112314,
0.02925009,
0.0145175075,
-0.001585332,
-0.00057885196,
0.025526617,
-0.0434181,
0.02082187,
-0.0046341764,
-0.008986068,
0.03290635,
0.008387893,
-0.005373494,
-0.019343235,
-0.00022347551,
0.011674495,
-0.0012610405,
-0.0026228968,
-0.019034065,
0.0063715726,
-0.006915979,
0.009295237,
0.010733546,
-0.0051617804,
-0.024652878,
0.0000836983,
0.015095519,
-0.008636572,
-0.0031488205,
0.0005229831,
0.0021490615,
-0.011795474,
0.008824763,
-0.021856913,
-0.03172344,
0.017609198,
-0.0045871288,
0.03379353,
0.017474778,
0.047612045,
-0.0057801185,
-0.009664896,
0.030432997,
0.00028732567,
-0.030217921,
-0.0058607715,
0.0064387834,
-0.012023991,
0.02731442,
0.015686972,
-0.0026329784,
0.019262582,
-0.026736408,
0.01579451,
0.030674955,
-0.018980296,
-0.025445964,
0.020741217,
-0.0338473,
-0.009927018,
0.0055079153,
-0.01157368,
-0.005121454,
-0.036723915,
0.011177137,
0.0016306991,
0.020364836,
0.014880445,
-0.0012593601,
0.02396733,
0.0021742654,
0.039734956,
-0.029223204,
0.032879464,
-0.026575103,
-0.015270267,
-0.008791157,
0.027287537,
0.0020213611,
0.012050875,
0.0032126706,
-0.0041435384,
0.0014903968,
-0.004832448,
0.030486764,
-0.0041569807,
-0.04046083,
0.0025187202,
-0.021534301,
-0.00950359,
-0.0022565986,
-0.0038814167,
-0.04731632,
-0.0022834828,
-0.011412374,
-0.003787322,
0.011062878,
0.0012425574,
-0.008912137,
0.035137743,
0.0059750294,
0.029357625,
-0.0086567355,
0.013220341,
0.003360534,
0.005669221,
-0.015673531,
-0.0028850185,
-0.005581847,
0.005531439,
0.018993739,
0.014329317,
0.0024363871,
-0.0067042653,
-0.009631291,
-0.019181928,
-0.008152655,
-0.016883323,
0.015767626,
-0.015014866,
0.00899951,
0.009154094,
-0.0019625518,
-0.009718665,
0.017985579,
-0.020660564,
0.024451246,
0.0035688872,
-0.022246735,
-0.023685044,
0.0070436792,
-0.014060475,
0.0178646,
-0.017945252,
0.003266439,
0.03140083,
-0.025177121,
0.014436854,
0.032637507,
-0.004472871,
0.012985104,
-0.011795474,
-0.0144099705,
-0.002108735,
0.002982474,
0.0045400816,
-0.0092280265,
0.00020572769,
0.042692225,
-0.017582314,
0.0040729675,
0.0085491985,
0.012991825,
0.008797878,
0.005763316,
0.0069630267,
-0.0136236055,
-0.03239555,
-0.0066605783,
-0.0039116614,
0.0073326854,
-0.0063110827,
-0.026534777,
-0.021198248,
0.00446615,
-0.008152655,
-0.016036468,
0.028900594,
-0.046214063,
-0.01635908,
-0.012528071,
0.02895436,
0.013294273,
0.01063273,
0.014530949,
-0.008898694,
0.015108961,
-0.0007779636,
-0.0030177596,
0.0044123814,
-0.0025439244,
-0.0186308,
-0.009147374,
0.010491587,
-0.023537181,
-0.009039837,
-0.015565994,
-0.03454629,
0.0051248143,
-0.006348049,
0.005645697,
0.00020110696,
-0.032879464,
0.027717685,
-0.0058876555,
0.012111365,
-0.012097922,
-0.019800266,
0.013132967,
-0.004130096,
0.00043686942,
0.02812095,
-0.011002389,
-0.0231608,
-0.007406617,
-0.012360044,
-0.0008413937,
-0.010982226,
-0.01660104,
-0.00559865,
-0.008569362,
-0.009658175,
-0.014383086,
0.00078258436,
-0.024585668,
-0.016681692,
-0.00830724,
-0.012568397,
-0.001868457,
-0.02057991,
0.015754184,
-0.005134896,
0.0001440829,
-0.012467582,
-0.012978382,
-0.008844926,
-0.020727774,
-0.024451246,
-0.0057902,
-0.022811305,
0.02919632,
-0.0067345104,
-0.023483412,
-0.023120474,
-0.01868457,
-0.03594427,
-0.016144006,
-0.0023943805,
0.012474302,
0.031373944,
0.027032135,
-0.0044896733,
0.01938356,
0.022932284,
0.021668723,
-0.016708575,
-0.0210235,
0.0046778633,
-0.016063353,
0.0133009935,
0.008226587,
-0.01334132,
0.013778189,
0.009342285,
0.024746973,
-0.023819465,
0.021480534,
0.004708108,
0.01630531,
-0.0033168471,
0.008206424,
0.021883797,
0.024935164,
0.01793181,
-0.035406586,
-0.014423412,
0.0027405156,
0.0064959126,
-0.03817567,
0.005403739,
-0.012286113,
-0.016883323,
0.012225623,
-0.013912611,
-0.039035965,
0.010928457,
-0.041267358,
0.0255535,
-0.008596246,
0.02082187,
0.014799792,
0.00095355156,
-0.016506944,
-0.028577982,
-0.03242243,
-0.030567417,
-0.019074392,
0.02466632,
-0.005000475,
-0.02006911,
-0.023254896,
-0.0024901556,
-0.01459816,
0.00364954,
0.015902048,
-0.0025271217,
-0.036293767,
0.026023977,
0.014154569,
0.020593353,
-0.0123734865,
0.018146884,
-0.017273145,
-0.011661054,
0.0038108455,
-0.012763308,
0.013415252,
0.029061899,
-0.014907329,
-0.02398077,
-0.010605846,
-0.006677381,
0.002681706,
-0.01869801,
0.014732582,
0.18345827,
0.0028866988,
0.0045266394,
0.0071848216,
-0.01082092,
-0.004913101,
0.0031068136,
-0.003599132,
-0.022797864,
-0.009328842,
0.022381157,
-0.014907329,
-0.02391356,
0.0079241395,
0.02346997,
-0.0057801185,
-0.03051365,
0.008233309,
-0.011775311,
0.0140873585,
0.026736408,
-0.028094064,
0.0038814167,
-0.00016666148,
0.013361484,
0.002384299,
-0.021628397,
-0.006193464,
0.006253954,
0.005921261,
-0.032745045,
0.011855965,
-0.00459385,
0.007937581,
0.0043686945,
0.0031168954,
-0.0034747922,
-0.014961097,
0.00018860998,
-0.009456543,
-0.004661061,
-0.007473828,
-0.022421483,
0.0005528079,
-0.009355727,
-0.01705807,
-0.0020919323,
-0.013899169,
-0.023107031,
0.017004302,
-0.05056932,
-0.014450297,
-0.008448383,
0.02170905,
0.019074392,
-0.013132967,
0.014732582,
0.009355727,
0.0019709533,
0.02919632,
0.006469028,
0.026924599,
-0.03562166,
-0.004398939,
-0.030110385,
0.01743445,
-0.01717905,
0.0073528485,
0.030890029,
-0.051322076,
-0.0020919323,
-0.0056490577,
0.011156973,
0.012998546,
0.00924819,
-0.011876128,
0.024518456,
0.015028308,
0.019047506,
0.014463739,
0.023738813,
-0.0027035496,
-0.0137311425,
-0.009268353,
0.0056625,
-0.0076552965,
0.0255535,
-0.008145935,
-0.015256825,
-0.004422463,
0.0038780563,
-0.004190586,
-0.00811905,
0.006707626,
-0.0007481389,
-0.019397002,
-0.016574154,
-0.0029959162,
-0.0074335015,
-0.0004423303,
-0.046160296,
0.06850113,
-0.0032832418,
0.008468546,
-0.018079674,
0.018025905,
0.0014668731,
0.010652893,
0.0015307233,
-0.011190578,
0.019074392,
-0.01586172,
0.016816113,
-0.008152655,
-0.0055919285,
0.03304077,
0.0024767136,
-0.045972105,
0.03392795,
-0.0066941837,
0.0027455564,
-0.030298576,
-0.020929405,
0.00811905,
-0.007574644,
-0.0017575594,
-0.038148783,
0.009154094,
-0.0039083012,
-0.022287061,
-0.006700905,
0.0178646,
0.021735935,
0.022690326,
0.010222744,
0.0002751437,
0.026991809,
-0.017192492,
0.0005116413,
0.003693227,
0.005941424,
0.008105608,
0.00017936851,
0.008522314,
0.00018871498,
-0.0036663427,
0.023120474,
0.015068634,
-0.0067412313,
-0.011681217,
-0.02158807,
0.00213898,
0.0035924108,
0.016493501,
-0.007984629,
-0.02240804,
-0.021225134,
-0.029545816,
-0.01893997,
0.013368204,
-0.04368694,
0.0072654746,
0.010525193,
-0.0060388795,
-0.009086884,
0.024706647,
-0.16915584,
-0.001025803,
-0.006344688,
-0.011123368,
0.02246181,
0.043498755,
0.015055193,
-0.008293798,
-0.008387893,
0.010491587,
0.005195386,
0.013764747,
-0.03919727,
-0.020902522,
-0.005104651,
-0.0077426704,
0.010276513,
0.0093154,
0.014100801,
-0.0012602003,
0.010612567,
-0.028739287,
0.008401335,
0.0036461793,
0.0074805487,
0.015028308,
-0.0044762315,
-0.014665371,
0.006475749,
-0.027475726,
-0.012286113,
0.0049870326,
0.024357151,
-0.014746023,
0.0071848216,
-0.010370608,
0.00057759177,
-0.0034260645,
0.00036860857,
0.023201127,
0.015471899,
0.029868426,
0.01478635,
-0.033551574,
0.020136321,
0.02271721,
0.009893413,
-0.037826173,
0.009402774,
0.009416216,
0.027556378,
-0.0082803555,
0.0014299073,
0.0074671065,
0.011519911,
-0.005558323,
-0.012628887,
0.008912137,
-0.0094968695,
0.0035151187,
-0.0026010533,
-0.010915015,
0.045757033,
-0.003138739,
-0.009483427,
-0.0276908,
-0.019464213,
0.02687083,
-0.034492522,
0.025876112,
0.009080163,
0.004882856,
0.014772908,
-0.046966825,
0.016412849,
-0.0077493917,
-0.0053533306,
0.026911156,
-0.0066471365,
-0.020606795,
0.0018180489,
0.015633205,
-0.016036468,
-0.015915489,
-0.013791632,
-0.008965905,
-0.03505709,
0.018711453,
-0.011345163,
-0.0059918324,
0.0075410386,
-0.01842917,
-0.0032059494,
-0.0015903728,
-0.00100648,
0.0252981,
-0.006280838,
-0.009799317,
0.00421411,
0.0059078187,
0.004190586,
-0.0063782935,
-0.0057666763,
0.018724896,
0.029411394,
0.01522994,
-0.008273635,
-0.01660104,
0.058177564,
0.0014668731,
-0.024773857,
-0.002611135,
-0.0085491985,
0.019289466,
0.00427796,
0.042020116,
0.0049903933,
0.026467565,
-0.00085189537,
-0.01868457,
0.07963122,
-0.0037537166,
-0.00761497,
0.01365721,
-0.003002637,
-0.0073394063,
-0.12194706,
0.007319243,
0.002145701,
0.050139166,
-0.00068428874,
0.012077759,
-0.0020062388,
0.015364362,
-0.016385963,
0.020741217,
-0.005020638,
0.010921735,
0.015176171,
-0.005669221,
-0.012044154,
0.012736424,
-0.009664896,
-0.004808924,
-0.036455072,
0.013993264,
-0.0093355635,
0.00711089,
-0.0007040319,
-0.013650489,
0.023832908,
0.00080064725,
-0.025365312,
0.026575103,
0.005380215,
0.019155044,
-0.021722492,
-0.012971661,
0.0038914985,
0.0053331675,
-0.017461335,
-0.006267396,
-0.016654806,
-0.03140083,
0.030217921,
0.0033790169,
-0.0064455043,
-0.019719614,
0.018913087,
-0.00071579375,
0.027798338,
-0.008865089,
0.009711944,
0.009449822,
-0.012655771,
-0.014181454,
-0.028739287,
0.005511276,
-0.039681185,
0.004808924,
0.01246086,
-0.022327388,
0.008972626,
0.01617089,
-0.0101756975,
-0.027959643,
0.0014517508,
-0.011143531,
-0.022058545,
-0.0055011944,
0.004234273,
-0.008092166,
-0.0046778633,
-0.017918367,
0.0011879487,
-0.03390107,
0.0023876594,
0.0063346066,
-0.015297151,
-0.003662982,
-0.030352343,
-0.012044154,
-0.01912816,
-0.010982226,
0.028900594,
0.0070772846,
0.006519436,
-0.022287061,
0.01686988,
-0.014880445,
0.0090667205,
0.0011140171,
0.012077759,
0.0057397923,
0.0058641317,
-0.016023027,
-0.013899169,
0.025163678,
0.013549673,
-0.019558309,
-0.029061899,
0.026924599,
-0.017904926,
-0.011903011,
0.015646646,
0.002874937,
-0.03390107,
-0.015041751,
-0.06656546,
0.013993264,
-0.008045118,
-0.006233791,
0.00578684,
-0.0024061424,
0.00046795438,
-0.008992789,
0.018603917,
0.007090727,
-0.03201917,
0.0051382566,
-0.012071039,
-0.012662493,
-0.037853055,
-0.00950359,
0.01994813,
-0.0105319135,
-0.00034403466,
0.010780593,
0.015122403,
0.0018096475,
0.012608724,
0.028739287,
-0.0006183383,
-0.018456053,
0.004486313,
0.007319243,
-0.009832922,
0.004765237,
0.008011513,
-0.048902493,
-0.030352343,
-0.00018377921,
-0.003938546,
-0.02152086,
-0.00937589,
0.023523739,
0.021090712,
0.043713827,
-0.030755607,
-0.039950028,
0.011049436,
0.0071243322,
-0.0033168471,
-0.009268353,
-0.039466113,
0.018644243,
0.0073394063,
-0.005450786,
0.057747416,
0.0052457936,
-0.0016332195,
-0.019262582,
-0.018039348,
0.004506476,
-0.00081198907,
-0.026776735,
0.019491097,
-0.02925009,
0.008596246,
0.02863175,
0.018321631,
0.008992789,
-0.010142092,
0.0018012463,
-0.008078724,
-0.036643263,
-0.018590475,
-0.04183193,
-0.024061425,
0.027099347,
0.007594807,
0.012386928,
-0.0026665838,
-0.007702344,
-0.017286588,
-0.0053096437,
-0.0030681675,
0.0022565986,
-0.000031767548,
-0.0028766172,
-0.012534792,
0.011056157,
0.04796154,
-0.022891957,
0.005558323,
0.020378279,
-0.002480074,
0.012608724,
0.01038405,
0.024451246,
0.0037940429,
0.018173767,
-0.007507433,
-0.0063144434,
-0.013684095,
0.0025472848,
0.002668264,
0.007285638,
0.0062136273,
-0.00047719583,
0.01686988,
-0.015270267,
-0.017232819,
0.027717685,
-0.034331217,
-0.028094064,
-0.005447426,
0.006361491,
0.009725385,
-0.0057733976,
0.011062878,
0.0075208754,
0.015646646,
0.028819941,
-0.011815637,
-0.0018163687,
-0.0017441171,
0.002989195,
0.01799902,
0.018214095,
0.0013316117,
0.008650015,
0.029169435,
0.007319243,
0.018738339,
-0.009530474,
-0.0014710738,
-0.019208813,
0.038659584,
-0.005638976,
-0.031105103,
-0.014302433,
-0.015928932,
0.018509822,
0.0050071958,
0.043122374,
-0.032771926,
0.08199703,
0.01478635,
-0.027610147,
-0.0025035979,
-0.02328178,
0.019961573,
0.01157368,
-0.0019793545,
-0.010679777,
-0.033067655,
0.009207863,
-0.005985111,
0.01478635,
-0.030916912,
-0.007413338,
0.012843961,
-0.0023960609,
0.0128910085,
-0.034815133,
-0.018321631,
0.02396733,
-0.018012462,
0.009940459,
0.008072003,
-0.02806718,
0.0050979303,
0.014692255,
0.008394614,
0.02403454,
-0.018160326,
0.027744569,
-0.021010058,
-0.0128910085,
-0.011089763,
0.008213146,
-0.0045031155,
-0.009429659,
0.00077040243,
0.038417626,
0.011177137,
0.000051851992,
-0.009846365,
0.012050875,
-0.032234244,
0.012299554,
-0.0105856825,
0.020566469,
0.004335089,
-0.0042745993
] |
We previously reported a strong IL4I1 gene expression in primary mediastinal B-cell lymphoma (PMBL) and recently identified the protein as a secreted L-phenylalanine oxidase, physiologically expressed by myeloid cells, which inhibits T-cell proliferation in vitro. Here, we analyzed the pattern of IL4I1 protein expression in 315 human lymphoid and non-lymphoid malignancies. Besides PMBL, IL4I1 expression in tumors was very frequent. IL4I1 was detected in tumor-associated macrophages from most of the tumors and in neoplastic cells
|
[
-0.027466025,
0.007819275,
-0.027492309,
-0.047756717,
-0.024220042,
0.013483322,
-0.023615526,
-0.0037092278,
-0.036113225,
-0.01018477,
0.015047177,
-0.010086209,
0.009245143,
0.014955185,
-0.03101427,
0.0066726673,
0.036244642,
-0.0030406467,
-0.008752332,
0.025994163,
-0.038110755,
0.018332588,
-0.015454568,
-0.037585087,
-0.0012870593,
0.0067679444,
0.006101006,
-0.048545215,
-0.0067482316,
-0.014324387,
0.012116591,
0.01851657,
-0.022104237,
0.024496015,
0.0006620101,
-0.028044257,
0.0018086181,
0.0003533869,
0.025507921,
0.0035186738,
0.019226218,
0.01435067,
-0.0034135408,
-0.0020533812,
-0.0051778057,
0.0099547915,
0.01034247,
-0.013877571,
-0.011190106,
0.014087837,
0.023602383,
-0.014836911,
0.0043301703,
-0.0048065544,
-0.019213077,
-0.0055523426,
0.014508369,
0.026401553,
-0.0044024494,
-0.015323152,
-0.004369595,
-0.017662363,
-0.027571158,
0.012688253,
0.007024206,
0.0019055377,
-0.00038336625,
0.030462319,
0.0064065494,
-0.018385153,
0.04297316,
0.019423343,
-0.02268247,
0.00027720645,
0.019252501,
-0.013391331,
-0.02548164,
-0.005217231,
-0.016413907,
-0.012865664,
0.03093542,
-0.018950244,
-0.004211895,
0.02252477,
0.030199487,
-0.008036112,
-0.003111283,
0.018174887,
0.0070570605,
-0.011919467,
0.026966644,
0.018464003,
0.029043023,
0.0079506915,
-0.016505899,
-0.0049642543,
0.0051909476,
0.03953005,
0.017452097,
-0.034772776,
-0.013877571,
-0.0015096458,
-0.021907113,
-0.0073921722,
-0.039898016,
-0.0061042914,
-0.0101782,
-0.008555207,
0.032827813,
0.007175335,
-0.015743684,
0.030173203,
0.012057454,
-0.03721712,
0.02486398,
-0.008962598,
0.0070504895,
-0.010500169,
-0.018542852,
0.0040344833,
0.0051679495,
0.023234418,
0.0047441316,
-0.021434013,
0.030488603,
0.008082109,
-0.00026858225,
-0.024758847,
-0.041343596,
0.012037742,
0.018332588,
0.031382233,
0.0006369588,
-0.0150734605,
-0.009928509,
-0.00898231,
-0.014219253,
-0.009277998,
-0.014298104,
-0.017649222,
0.006997923,
0.032538697,
0.013397901,
0.009356847,
0.005154808,
0.014324387,
0.020553524,
0.0033938284,
-0.009941651,
0.006051725,
-0.040528815,
-0.019265642,
0.013319052,
-0.0030488602,
0.00800983,
0.002376994,
-0.012497699,
0.051646642,
-0.037585087,
-0.0018940388,
-0.0020993769,
-0.008686624,
0.02092149,
0.008712906,
0.014731778,
0.032459848,
0.0021305883,
0.0048689772,
-0.0073921722,
-0.012714536,
-0.009015164,
0.030987985,
-0.03369516,
0.017360106,
-0.011728913,
0.011216389,
0.011347805,
0.0014365454,
-0.015533417,
-0.008193812,
0.00027022496,
0.046153437,
0.02220937,
-0.005098956,
-0.014692353,
0.017123556,
0.02011985,
-0.019305067,
-0.018122321,
-0.022905877,
-0.0124779865,
0.012248008,
0.018621704,
-0.034667645,
-0.6337424,
-0.02541593,
0.02075065,
0.0074710217,
-0.0016361341,
0.03671774,
-0.005972875,
-0.016689882,
-0.020014716,
0.010881278,
-0.010671011,
0.032748964,
-0.010769573,
-0.020803215,
0.01579625,
-0.045496356,
-0.007687859,
-0.026664386,
0.00091498665,
-0.009087443,
-0.0043893075,
-0.004280889,
0.014810627,
0.022787603,
-0.0137461545,
0.011400372,
0.051357526,
-0.034720212,
0.0078587,
0.019909583,
0.0070176353,
0.019226218,
0.0025511207,
-0.0055983383,
0.04833495,
-0.0092188595,
-0.005371645,
0.0119588915,
0.031040551,
0.026887793,
0.0037420818,
-0.008246379,
0.0060155853,
-0.0006928108,
-0.027781425,
0.03527216,
0.011840617,
0.028832756,
0.0150866015,
-0.027571158,
-0.005828317,
-0.011446368,
-0.01499461,
-0.011604068,
0.019896442,
0.012898519,
0.03737482,
-0.0141929705,
0.0035318155,
0.0016303846,
-0.0018891107,
0.022748178,
-0.0018266878,
-0.011196677,
0.0032279151,
0.0020583093,
-0.0040443395,
-0.009507976,
-0.00031519402,
0.0130825015,
0.020067284,
0.04938628,
-0.0010973269,
0.01570426,
0.016926432,
0.018069753,
0.010808999,
0.010789285,
-0.0040213414,
0.008752332,
0.004501011,
0.0017182693,
-0.031881616,
-0.01058559,
0.029778954,
0.006022156,
-0.023510393,
0.02925329,
-0.0024427022,
-0.0026233997,
0.027886558,
-0.00063162006,
-0.0060648667,
-0.024404025,
-0.045180954,
-0.0017856202,
-0.009908796,
0.013358477,
0.009422556,
-0.02590217,
-0.02717691,
-0.0028533784,
0.013075931,
-0.009258285,
0.016295632,
0.003935921,
-0.036165792,
-0.0065543926,
0.022314504,
-0.025008539,
0.021696847,
-0.0013667304,
-0.006781086,
-0.0032870525,
-0.007497305,
-0.017044706,
0.02084264,
-0.00043942357,
-0.006639813,
-0.013167922,
-0.0009305923,
-0.009153152,
0.010243908,
0.0052533704,
0.015165452,
0.0111506805,
0.009711672,
-0.0089166025,
0.024574865,
-0.0044221617,
0.0017544088,
-0.008857464,
0.031802766,
-0.026033588,
0.03953005,
0.017005282,
0.037742786,
0.016137933,
0.006879648,
-0.025284514,
-0.024798274,
-0.008634057,
0.00035954703,
-0.018069753,
-0.012543695,
-0.004136331,
-0.012727678,
0.0028698056,
0.0049412563,
0.018831968,
0.0039786315,
0.005900596,
0.010657869,
0.018043472,
0.026388412,
-0.0076287217,
-0.027439743,
-0.018569136,
-0.010631586,
-0.0027630297,
-0.01601966,
0.0065281093,
0.004169185,
-0.00038398226,
0.00857492,
-0.013036506,
0.0013979418,
0.012175729,
0.0028435222,
-0.033563748,
0.005243514,
0.006189712,
-0.015283726,
0.01796462,
0.011696059,
-0.024036057,
-0.002009028,
-0.02085578,
0.00014291532,
0.00011827475,
0.0076812883,
-0.0021519435,
-0.003178634,
0.0035482426,
0.035245877,
0.027045494,
0.020093566,
0.018713694,
0.020277549,
0.024193758,
-0.009961363,
0.024272608,
-0.020422107,
0.031802766,
0.006846794,
-0.010092779,
0.00954083,
0.0066233864,
0.0073264637,
0.024798274,
-0.021381447,
-0.022892736,
0.012064025,
-0.011380659,
0.0056049093,
-0.04281546,
-0.0093634175,
-0.02893789,
0.02397035,
0.014442662,
0.009836517,
0.014955185,
-0.0058381734,
0.0005351111,
0.00048459796,
0.015047177,
0.010697294,
-0.00721476,
0.008634057,
-0.019199936,
-0.011091543,
0.017452097,
0.014245537,
-0.0094356965,
-0.014679211,
-0.006229137,
0.021052906,
0.017596655,
-0.0032739108,
-0.0031934183,
-0.011006122,
0.007582726,
0.02525823,
-0.00050882786,
-0.00858149,
0.00093141367,
0.009948221,
-0.015756825,
0.045575205,
-0.0059860167,
-0.012563407,
0.0059104525,
0.008075537,
0.018345729,
-0.00004671442,
-0.012675111,
0.011748626,
0.0034463948,
-0.0022718608,
0.025823321,
-0.011170394,
0.018542852,
-0.0021798695,
-0.0031408519,
0.0024706281,
0.00914001,
0.004363024,
0.015585984,
0.04281546,
0.0075892964,
0.014955185,
-0.018713694,
0.009987646,
-0.018135462,
-0.005292795,
0.0055523426,
-0.010105921,
-0.011216389,
-0.0034661074,
-0.0059367353,
-0.025823321,
0.025429072,
0.04938628,
-0.047677867,
0.009665675,
0.010631586,
0.016992139,
0.019738743,
0.016663598,
0.011347805,
-0.028017975,
-0.03493048,
-0.006574105,
0.026506687,
-0.015993375,
-0.01891082,
-0.02316871,
-0.0083252285,
-0.010605303,
0.009626251,
0.0118143335,
0.008640627,
-0.013259914,
0.010776144,
-0.004264462,
-0.01851657,
0.03022577,
-0.016335057,
0.015139168,
-0.006071437,
-0.00039465984,
0.0012878807,
-0.006662811,
-0.0029700105,
0.032118168,
0.010854994,
-0.010533024,
-0.016768731,
0.00014250465,
-0.018004045,
-0.0015104671,
-0.0242069,
0.004632428,
-0.010565878,
0.0013174494,
-0.012123162,
0.028885324,
0.010165058,
0.017307539,
0.0073396056,
-0.025941595,
-0.026822086,
0.00914001,
0.0009774094,
0.0052599413,
0.019357635,
-0.0065708198,
0.011262385,
-0.02332641,
0.0093634175,
-0.0035285302,
-0.009672247,
0.017728072,
0.002500197,
0.01347018,
-0.0019351064,
-0.00028213457,
0.008404078,
-0.00785213,
-0.0009429126,
0.009021736,
-0.027597442,
0.002255434,
0.005338791,
0.0019696031,
0.005637763,
0.0035876676,
0.022064812,
0.015388859,
0.0068730772,
0.0076747173,
0.009002022,
0.008430362,
-0.011978604,
-0.010684153,
0.012530553,
-0.0026956787,
-0.00034886945,
0.00069691753,
-0.02084264,
0.012248008,
0.023707516,
0.009843088,
-0.0067942273,
0.036822874,
0.019134227,
0.005069387,
0.0015318224,
-0.0018677554,
0.013115356,
-0.010500169,
0.021499721,
0.020895207,
-0.023103002,
0.022445919,
-0.021420872,
-0.0075170174,
-0.022459062,
0.0006702236,
0.0061667142,
-0.019751884,
-0.00023552282,
-0.0073856013,
0.0035219593,
0.0029601543,
-0.03203932,
0.015099743,
0.0030258624,
-0.013220489,
0.0022899306,
-0.010835282,
-0.0099547915,
-0.020803215,
-0.03132967,
0.017425813,
-0.011636921,
-0.020974057,
-0.0037880775,
0.020343257,
0.022971585,
0.012727678,
-0.00629156,
-0.0013519461,
0.024390882,
-0.020382682,
-0.011604068,
0.0029355136,
-0.034168262,
0.012773673,
0.0078652715,
0.004221752,
-0.036349773,
-0.0104016075,
-0.016571607,
-0.0064722574,
0.0010800784,
0.019686176,
-0.0030849997,
0.0002747424,
0.018293161,
0.010132204,
0.031881616,
-0.017767496,
-0.0049773958,
-0.024272608,
-0.017031565,
-0.03311693,
-0.0039556334,
-0.008910031,
0.000108726534,
0.002749888,
-0.0047474173,
-0.014455803,
-0.009008594,
0.015664835,
0.00028418796,
-0.0074907346,
0.0055523426,
0.0036040945,
0.038347304,
-0.021118615,
0.017990904,
0.03062002,
-0.020632373,
-0.011025836,
-0.009245143,
0.022905877,
-0.0072279014,
-0.020474674,
-0.00071991544,
-0.009672247,
-0.012970798,
-0.008187241,
-0.007733855,
-0.006360553,
0.0028813044,
0.0074644512,
-0.031066835,
-0.04980681,
-0.0075433007,
0.0009979432,
-0.0052369433,
0.0056180507,
-0.026112437,
-0.017215548,
0.0083975075,
-0.012195441,
-0.009041448,
0.024785131,
-0.026165003,
-0.019659892,
0.023536677,
-0.007792992,
-0.0049511124,
-0.025783896,
0.018227454,
-0.0022110809,
-0.00206488,
-0.013509605,
-0.024601148,
0.0009174507,
-0.020093566,
0.030146921,
0.013115356,
0.029016739,
-0.012451703,
0.028569924,
0.027308326,
0.0032246297,
0.0038077899,
0.003784792,
0.011341235,
-0.001449687,
0.0053256494,
0.004872263,
0.0053946427,
0.04079165,
-0.03030462,
0.008404078,
0.023497252,
-0.017701788,
-0.004921544,
0.009915367,
-0.026743235,
-0.03855757,
0.014718636,
-0.014376953,
0.011242673,
-0.032013033,
-0.008147816,
0.036612608,
-0.00016344913,
0.019515334,
0.0025199093,
0.012773673,
-0.027387176,
0.026887793,
-0.005506347,
0.0009946579,
-0.008601203,
-0.012339999,
-0.0017626224,
-0.010946985,
0.012537124,
-0.0051153833,
0.002115804,
0.0037223692,
-0.04386679,
0.017754355,
-0.027071778,
-0.024312032,
-0.007641863,
-0.03839987,
-0.00010780251,
-0.007957263,
-0.0073856013,
-0.022958444,
-0.044182193,
0.015126027,
0.00881804,
-0.008141246,
0.005923594,
0.0022242225,
-0.025875887,
0.050569028,
-0.002533051,
0.028596207,
-0.015585984,
0.021749413,
0.015020894,
0.008699765,
-0.022091096,
-0.0015737113,
-0.0053223637,
-0.0011063617,
0.02717691,
0.010592162,
-0.029227005,
-0.0058381734,
0.007687859,
0.0045240093,
0.005565484,
-0.013351905,
0.011374089,
-0.008962598,
0.0020500957,
-0.026795803,
-0.019791309,
-0.041974396,
0.0074053137,
-0.004563434,
0.022406494,
-0.005706757,
0.00091580796,
-0.004514153,
0.010828711,
-0.007825846,
0.003791363,
-0.008995452,
-0.031224536,
-0.0037223692,
-0.018109178,
-0.0038012192,
-0.00412976,
-0.0007884984,
0.023799509,
0.0027301756,
0.010467316,
0.0012156016,
0.006669382,
0.0054669217,
0.0032476275,
0.0024542012,
0.0392935,
-0.013916996,
0.022472203,
-0.010513311,
0.0010061568,
-0.0006246385,
-0.01435067,
-0.0056706173,
-0.019305067,
-0.021736272,
-0.0074644512,
0.031093119,
0.033222064,
-0.013969563,
0.02717691,
-0.034273393,
-0.015967092,
-0.02397035,
-0.013562172,
-0.0062389933,
-0.044918124,
0.008298946,
-0.009048019,
0.02076379,
0.018792544,
0.023523534,
-0.01779378,
0.0029519408,
0.030593736,
-0.016795015,
0.01114411,
0.0014217611,
0.016295632,
-0.013496463,
0.005220516,
-0.0044681574,
0.008318658,
0.021828262,
-0.0047342754,
-0.019042235,
-0.016532183,
0.0015597483,
0.004448445,
0.018345729,
-0.013246773,
0.017609797,
-0.0008135496,
0.029227005,
0.005828317,
0.00034620005,
0.012859094,
-0.029516121,
-0.0048985463,
0.010296474,
0.010217625,
-0.020408966,
0.010927273,
-0.006432832,
0.0016796658,
0.0025166238,
-0.020974057,
-0.020632373,
0.00030205236,
0.001859542,
0.006886219,
-0.015967092,
-0.002754816,
-0.00858149,
0.014245537,
0.003045575,
0.0043104575,
-0.014311245,
0.013115356,
0.0026677528,
0.02299787,
-0.03030462,
0.0072541847,
0.011084973,
-0.027466025,
-0.0035975238,
-0.001561391,
-0.016269349,
0.022248795,
-0.002901017,
0.0066201007,
-0.025376506,
-0.008456645,
-0.047020786,
-0.0068007982,
-0.0021519435,
0.011242673,
-0.015388859,
0.0070964852,
-0.013877571,
0.00020749416,
-0.015599126,
0.01747838,
-0.0073724594,
-0.04504954,
-0.0033133358,
0.0041100476,
0.020500958,
-0.007070202,
-0.007806134,
-0.025429072,
0.017018422,
-0.0029880803,
-0.01258969,
0.023221277,
-0.041107047,
0.010651299,
-0.023431543,
0.011242673,
0.0053322203,
0.010710436,
0.0056147655,
-0.0157174,
-0.0054077846,
0.0016246352,
0.01563855,
0.019055378,
0.005006965,
-0.008837752,
0.028096825,
-0.009652534,
-0.0054143555,
-0.026756378,
0.011558072,
-0.026480403,
0.0147843445,
0.016492758,
-0.005072673,
0.012878806,
-0.011689488,
0.0031277102,
-0.022629904,
-0.022472203,
-0.022012245,
0.007510447,
0.015585984,
-0.008239808,
-0.004855836,
0.0053092223,
-0.005923594,
-0.024233183,
-0.011965463,
-0.0063244137,
-0.003071858,
-0.029305855,
0.018477146,
0.017649222,
-0.021854546,
-0.009639393,
-0.02125003,
-0.008305516,
-0.025100531,
0.004872263,
0.0007149873,
-0.027991692,
-0.020566665,
-0.0062389933,
-0.0028369513,
-0.0064558303,
-0.01299051,
-0.018266879,
0.007963833,
0.013733013,
0.19386546,
-0.023996633,
-0.01370673,
0.0024788417,
-0.0077798506,
0.00009532822,
0.0059038815,
0.0027860275,
0.002498554,
0.008193812,
0.022748178,
-0.003863642,
0.0030817145,
0.0038275025,
0.0050956705,
-0.0044780136,
-0.01098641,
-0.005378216,
-0.009192577,
-0.017360106,
0.0055424864,
-0.018253736,
0.018214311,
0.009448838,
0.024193758,
0.00785213,
-0.012510841,
0.026243854,
0.01612479,
0.00841722,
-0.02381265,
0.009389701,
-0.014074695,
-0.009166294,
0.0017461954,
0.008088679,
-0.017360106,
-0.02260362,
0.0111506805,
0.0014086195,
-0.005161379,
-0.003183562,
-0.005516203,
0.0014242252,
-0.0067679444,
0.01601966,
-0.00080944283,
-0.008272662,
-0.003991773,
0.0049576834,
-0.035245877,
0.025008539,
0.004303887,
0.008653769,
0.015940808,
0.0061699995,
0.020316975,
0.030041788,
-0.009843088,
0.012116591,
-0.015835674,
0.00034948546,
-0.03448366,
0.0078652715,
-0.012819669,
0.02075065,
0.007727284,
-0.009422556,
0.022143662,
-0.034588795,
0.018555995,
0.0046882797,
-0.0028796617,
-0.001388907,
-0.017005282,
-0.015559701,
0.03600809,
0.028990457,
0.0033741158,
0.012721106,
-0.001533465,
0.006150287,
-0.046074588,
0.0036533757,
-0.014114121,
-0.026401553,
-0.0009207361,
0.002855021,
-0.02814939,
-0.021026623,
0.0009264856,
-0.03288038,
-0.0056246216,
0.0069387853,
0.011176964,
0.0014119048,
0.0069387853,
0.0001260776,
-0.009429126,
-0.026730094,
0.005440639,
0.06644413,
0.014245537,
0.010710436,
-0.0031309957,
0.0042513204,
0.007438168,
-0.0052697975,
-0.0144820865,
0.009199147,
0.020803215,
-0.046626534,
-0.0010455817,
-0.013233631,
0.0122611495,
0.002570833,
0.00028583064,
-0.014810627,
0.02372066,
-0.013982704,
0.012004888,
-0.024114909,
0.013877571,
0.036192074,
-0.011788051,
0.014206112,
-0.021066047,
0.010552736,
-0.0065609636,
-0.021013482,
-0.0056903297,
0.013719872,
0.0042348932,
0.025731329,
0.0020615947,
-0.0023753513,
-0.008995452,
0.0043400265,
-0.008995452,
-0.005305937,
0.0001659132,
-0.022025388,
-0.0019121085,
-0.008049254,
0.007825846,
-0.0066923797,
0.012320287,
0.004284174,
-0.016177358,
-0.018306304,
-0.018148603,
-0.040528815,
-0.015730543,
-0.004914973,
0.03550871,
-0.022721894,
-0.012254579,
-0.0056147655,
0.0022077954,
-0.00049815024,
-0.011906325,
0.025429072,
0.01716298,
-0.0028106682,
-0.00969853,
-0.011991746,
-0.16453332,
-0.0041757557,
0.020960914,
-0.017412672,
0.019594185,
0.022380212,
-0.008187241,
-0.011288668,
-0.0005330577,
0.014521511,
0.03695429,
0.007352747,
-0.043235995,
-0.012287432,
-0.024022916,
0.0036008093,
-0.004510868,
0.032591265,
0.020947773,
0.009120298,
0.026348988,
-0.008864036,
0.018700553,
-0.014850052,
-0.0005400392,
0.0110652605,
0.016216783,
0.0032361287,
-0.014245537,
-0.032407284,
-0.013062789,
0.009718242,
0.01746524,
0.002565905,
0.034509946,
-0.00621271,
0.021394588,
-0.021815121,
-0.005999158,
0.0034595365,
0.03942492,
0.0133716175,
0.010493599,
0.010881278,
-0.0072016185,
0.036297206,
0.03808447,
-0.0022225797,
0.044786707,
0.0052533704,
0.02453544,
-0.030646304,
0.025507921,
-0.00008470197,
0.006741661,
0.012248008,
0.02140773,
0.021289455,
0.0002531819,
0.009521117,
-0.008594632,
-0.01427182,
0.017228689,
-0.0037749358,
0.01347018,
-0.018779403,
-0.0048788334,
0.027886558,
-0.024522299,
-0.0029519408,
-0.025218805,
-0.011952321,
0.033300914,
-0.011531789,
0.01667674,
0.015677975,
-0.0008657055,
0.007930979,
0.0025412645,
0.01057902,
-0.0033839722,
0.015034035,
-0.022708753,
0.017622938,
-0.030015504,
0.012734248,
0.0106184445,
0.039056953,
-0.0017839775,
-0.026848368,
0.01194575,
-0.020724365,
0.002505125,
-0.018871393,
0.021118615,
0.028017975,
-0.014810627,
-0.008699765,
-0.013496463,
0.015336293,
0.012635686,
-0.025836462,
-0.02620443,
0.0057691797,
0.026270136,
-0.009527689,
-0.00873919,
0.0013667304,
0.03934607,
-0.03824217,
-0.014666069,
-0.0050562457,
-0.004303887,
0.02925329,
-0.016689882,
0.0110652605,
-0.0006529752,
-0.014731778,
-0.007503876,
-0.016243067,
0.058664277,
-0.0027367463,
-0.0034726781,
0.024719423,
-0.022143662,
-0.020606091,
-0.12994453,
-0.027387176,
0.016374482,
-0.005798748,
-0.024745706,
0.011124398,
-0.009225431,
0.018871393,
-0.013575314,
0.035403576,
-0.0013133426,
0.006452545,
-0.0016468117,
-0.020619232,
0.013719872,
0.0018973241,
0.010500169,
-0.0023786367,
-0.02558677,
0.030909136,
0.009113727,
0.011873471,
-0.011912896,
-0.020408966,
0.008607774,
-0.0043268846,
-0.04836123,
0.015323152,
-0.0016369554,
0.0048196963,
0.024390882,
-0.0021190892,
0.014284962,
0.018963385,
-0.010730148,
0.0010751503,
-0.002510053,
-0.008502641,
0.037716504,
-0.006997923,
-0.0063342704,
0.018411437,
-0.0016969142,
-0.027912842,
0.0073396056,
-0.0094356965,
-0.014797485,
0.013200777,
0.026493546,
-0.00841722,
-0.012734248,
-0.0328541,
-0.04602202,
-0.004481299,
0.022419637,
-0.011893184,
0.00914001,
0.045154672,
-0.027071778,
-0.026795803,
0.0005556449,
-0.018805686,
-0.005171235,
-0.0013437326,
0.025047965,
0.0017823349,
0.018227454,
-0.035640124,
0.03093542,
-0.037006855,
-0.01971246,
0.0055293445,
-0.016808156,
0.0015293582,
0.0022455775,
-0.0089166025,
-0.019567901,
-0.020264408,
0.016873864,
-0.026585536,
-0.028438507,
-0.016624173,
0.011400372,
-0.01097984,
0.041238464,
0.010138774,
0.01612479,
-0.014863194,
0.00017063598,
-0.015664835,
-0.012307145,
0.053039655,
0.0021256602,
-0.0104738865,
-0.018884536,
0.018148603,
-0.0059827315,
-0.017846346,
0.018450862,
0.026007304,
-0.006853365,
-0.024969114,
-0.06455173,
0.028044257,
-0.016545324,
0.015901383,
0.017859487,
-0.022248795,
0.0017971192,
-0.020987198,
0.022301361,
0.013733013,
-0.0008525638,
0.032197017,
-0.017215548,
-0.00006935295,
0.0074644512,
-0.006741661,
0.030804003,
-0.00031724738,
-0.00023593349,
0.006340841,
0.0070373476,
-0.0065445364,
0.01939706,
0.008128104,
-0.020106709,
-0.0032722682,
-0.024574865,
0.050936993,
-0.0106184445,
-0.010454174,
0.0028698056,
-0.049833097,
-0.012648827,
-0.0089166025,
-0.03968775,
-0.04786185,
0.0092188595,
0.020080425,
0.014547795,
0.02036954,
-0.0049741105,
-0.03726969,
0.01739953,
0.009652534,
0.017333822,
-0.008456645,
-0.022629904,
-0.0036993714,
0.01194575,
-0.0097051,
0.040502533,
-0.0017330537,
-0.0031244247,
-0.058769412,
-0.006419691,
0.008476357,
0.009606538,
-0.0111375395,
-0.0019794593,
0.0062718475,
0.01499461,
0.0020041,
0.0011244315,
0.0133716175,
-0.008312087,
-0.0075564426,
-0.0017741213,
0.00681394,
-0.004202039,
-0.0045995736,
-0.005805319,
-0.0045174384,
-0.009961363,
0.012313716,
0.02917444,
-0.013667305,
-0.012675111,
0.0041757557,
-0.019055378,
0.019475909,
0.01331248,
-0.005378216,
0.0064262617,
0.008298946,
0.03440481,
0.0038899253,
-0.02236707,
0.032670114,
0.001714984,
0.009606538,
0.002649683,
0.0014776131,
0.021236889,
0.015191735,
0.006068152,
0.0065379655,
0.0000063558564,
0.0051088124,
-0.015664835,
0.05682445,
0.010447604,
-0.0326964,
-0.00016406515,
-0.029936654,
-0.030488603,
0.02364181,
-0.028412225,
-0.03140852,
-0.028569924,
0.007727284,
0.015585984,
0.010894419,
-0.007733855,
0.0016008159,
-0.02733461,
0.013286198,
-0.011577784,
0.006925644,
-0.010644727,
0.03637606,
0.013279626,
0.0023802794,
0.007845558,
-0.002321142,
-0.013522747,
0.006932215,
0.028175674,
-0.020947773,
0.022380212,
-0.005121954,
0.017202405,
-0.0013905497,
-0.031750202,
-0.017714929,
-0.0036862297,
0.0120246,
0.023365835,
0.033169497,
0.0027975265,
0.0807948,
-0.006715378,
-0.015572842,
-0.0034332532,
-0.004724419,
0.0028714482,
0.007319893,
0.014863194,
-0.0072541847,
-0.048597783,
0.011827475,
-0.015756825,
0.040765364,
-0.039740317,
-0.036744025,
0.0071161976,
-0.017833205,
-0.0068270816,
-0.011485793,
-0.01098641,
0.004928115,
0.0051252395,
0.0042348932,
0.009553972,
-0.036086943,
-0.006567534,
0.02291902,
-0.019686176,
-0.01458722,
-0.028228242,
0.010539595,
-0.0051088124,
-0.047677867,
-0.011104685,
0.026138721,
-0.04073908,
-0.01194575,
-0.025639338,
0.005657476,
0.027781425,
-0.010270191,
0.012793385,
-0.020343257,
-0.003334691,
0.023444684,
-0.018779403,
-0.014179829,
-0.0048131254,
-0.00077658874
] |
Pathway-specific therapy is the future of cancer management. The oncogenic phosphatidylinositol 3-kinase (PI3K) pathway is frequently activated in solid tumors; however, currently, no reliable test for PI3K pathway activation exists for human tumors. Taking advantage of the observation that loss of PTEN, the negative regulator of PI3K, results in robust activation of this pathway, we developed and validated a microarray gene expression signature for immunohistochemistry (IHC)-detectable PTEN loss in breast cancer (BC). The most significant signature gene was PTEN itself, indicating that PTEN mRNA
|
[
-0.02094007,
-0.019592442,
0.004512611,
-0.021587968,
-0.015381103,
0.030762207,
-0.020162592,
-0.0028734286,
-0.012569225,
0.008675357,
0.024646048,
-0.0018529888,
0.00050293095,
0.01929441,
-0.009893405,
0.007846047,
0.032990977,
-0.01495349,
0.003647667,
0.00534516,
-0.040973082,
0.028326109,
0.0001728066,
-0.02056429,
0.006624759,
0.0049467026,
0.027833708,
-0.059554804,
-0.007625762,
-0.021549094,
0.0157828,
0.0070750485,
-0.007910837,
0.008124643,
-0.008033938,
0.014525877,
0.021238104,
-0.0008957193,
0.02131585,
-0.0028086386,
-0.005801928,
0.0034824528,
-0.0074249133,
-0.023389125,
-0.018426225,
-0.008344929,
0.024257308,
-0.006605322,
-0.025423525,
0.028611185,
-0.015108986,
-0.011143849,
-0.012783032,
-0.015225608,
-0.016560279,
-0.010450598,
0.0028734286,
0.032498572,
0.011623294,
0.00451909,
-0.009744389,
-0.013268955,
-0.037966836,
0.032990977,
0.008331971,
-0.012847821,
0.009861011,
0.018607637,
0.0037286542,
0.019138914,
0.032239415,
0.026641574,
-0.028792595,
0.000941882,
0.017519167,
-0.020616122,
-0.02520324,
-0.007217586,
0.0013387196,
0.015653221,
0.031747013,
-0.020901196,
-0.0012650213,
0.015951253,
0.011312302,
0.0061388356,
-0.0024539144,
0.014603625,
0.021847127,
0.005319244,
0.01929441,
0.0152126495,
0.017454378,
0.017558042,
-0.005335442,
0.014862785,
-0.009109449,
0.013217123,
0.013865022,
-0.033016894,
-0.009180717,
-0.0004555534,
0.013126418,
-0.014577709,
-0.03366479,
-0.010508909,
-0.0009953337,
-0.0006725993,
0.021471346,
0.004282607,
-0.03410536,
0.035427075,
-0.024360972,
-0.022391362,
0.04809996,
0.009744389,
0.009336213,
0.0026499038,
-0.0053289626,
-0.0001585326,
0.020758659,
0.018102275,
0.006841805,
0.0022676438,
0.024412805,
-0.0049110684,
-0.014150097,
-0.0077164676,
-0.007871963,
0.0032637871,
0.010450598,
0.012549788,
0.008584651,
-0.004360355,
-0.026693406,
-0.0025446203,
-0.006446587,
-0.021510221,
-0.03213575,
-0.04965492,
-0.003793444,
0.020356962,
0.004272889,
-0.006077285,
-0.0070491326,
0.016793521,
0.0009394524,
0.003176321,
-0.0038031624,
-0.0054131895,
-0.0021396838,
-0.0004353066,
0.0016748168,
-0.013022754,
0.0015808716,
-0.0048397994,
0.023609411,
0.02468492,
-0.0047134594,
-0.014862785,
0.0037383726,
-0.0019274971,
0.0039003473,
0.021367682,
0.043875664,
0.018478056,
0.018542847,
0.012750637,
-0.006002777,
-0.013165291,
0.01698789,
0.021549094,
-0.032757733,
0.010262707,
-0.014655458,
0.006038411,
-0.010508909,
0.03340563,
-0.024348015,
-0.01215457,
-0.0008033938,
0.020408794,
0.011694563,
-0.0068806787,
-0.020862322,
-0.012634015,
0.013398535,
-0.026745237,
-0.012977401,
-0.03252449,
-0.011817663,
0.009861011,
0.010100733,
-0.0046000774,
-0.6464469,
-0.031176861,
0.005999537,
-0.013184728,
0.032731816,
0.030036561,
0.008319013,
-0.02463309,
-0.024024066,
0.009964675,
-0.010003548,
0.006478982,
-0.009401003,
-0.012634015,
-0.013191207,
-0.031073198,
-0.00757393,
-0.029466411,
0.017402546,
0.0036509063,
-0.022780102,
0.0015517162,
-0.007172233,
0.022818975,
0.0018610876,
0.026058465,
0.028948091,
-0.014914617,
0.010917084,
0.03260224,
-0.02933683,
0.012802469,
0.00114597,
-0.019242577,
0.049732666,
-0.0053548785,
0.0008997686,
0.02520324,
0.024360972,
0.05919198,
-0.0009443116,
-0.0030726572,
0.016793521,
0.007230544,
-0.041517317,
0.02411477,
0.010677363,
-0.00815056,
0.011888932,
-0.012932048,
0.0070685693,
-0.0073212497,
-0.032368995,
0.0013330505,
0.019100038,
0.015523641,
0.019048207,
-0.03379437,
0.0023065177,
0.015756885,
0.012394292,
0.02176938,
-0.0016084072,
-0.026317624,
-0.0013686849,
0.0137354415,
-0.017609874,
0.002985191,
-0.0017590437,
0.023492789,
0.025293946,
0.031850677,
-0.0066474355,
-0.0069519477,
0.020149633,
0.020123718,
-0.0031471655,
0.0003844871,
-0.0012326264,
-0.00617123,
0.020344004,
0.007366603,
-0.04677825,
0.022132203,
0.012653452,
0.022222908,
-0.01731184,
0.012517394,
0.025630852,
0.005186425,
0.013605862,
-0.012582183,
-0.012757116,
-0.03094362,
0.002094331,
0.008066333,
-0.003283224,
0.017570999,
0.0040331664,
-0.03830374,
-0.039806865,
-0.019514693,
-0.0101849595,
0.00026482838,
0.022689395,
-0.009206633,
-0.028118782,
-0.008876205,
0.029155418,
-0.032213498,
0.004224296,
-0.008215349,
0.001241535,
-0.009873969,
-0.00967312,
-0.021212187,
0.017039722,
0.021536136,
-0.012640494,
-0.020927113,
0.020007096,
-0.010010027,
0.010981875,
-0.015031238,
0.029673738,
0.011921327,
0.009614809,
-0.004162746,
0.0053743157,
0.010146086,
-0.016145622,
-0.037396684,
0.013437409,
-0.030451216,
0.0016796761,
-0.001311184,
0.001438334,
-0.0030321635,
-0.00078638643,
-0.017985655,
-0.015419977,
-0.014214886,
0.010748631,
0.018387351,
-0.004302044,
-0.0216398,
-0.030606711,
0.01711747,
0.014487004,
0.018529888,
0.0069908216,
-0.0067122253,
0.012925569,
0.015679136,
0.02526803,
-0.0120314695,
0.0027551872,
-0.023492789,
-0.009115928,
-0.03322422,
-0.012070344,
0.014292634,
-0.0029527962,
-0.02144543,
0.00027110492,
-0.01368361,
-0.0014901658,
0.012407251,
-0.009783263,
-0.024101812,
-0.025306905,
-0.003793444,
-0.016586194,
-0.00006691574,
0.023091093,
0.009433398,
0.00630081,
-0.020927113,
-0.0043538758,
-0.0018918627,
-0.005014732,
-0.0408435,
-0.019812727,
0.010074817,
0.027574547,
0.031798843,
0.0066668727,
0.021860085,
0.022417277,
0.040247437,
-0.022754185,
0.009206633,
0.008662399,
0.02196375,
0.015173776,
-0.02290968,
0.021743463,
0.013398535,
0.0057112225,
0.027522715,
0.01527744,
-0.0035861165,
0.026175087,
-0.0036185114,
0.0015865407,
-0.01744142,
-0.003832318,
-0.02933683,
0.020266255,
-0.0014885461,
-0.0014221366,
0.02845569,
-0.021108523,
0.0012010413,
-0.011241034,
0.019903433,
-0.007217586,
-0.015769843,
-0.011033706,
-0.005076282,
-0.006764057,
0.01317825,
-0.0039975317,
-0.010133128,
0.017337756,
0.0084226765,
0.01623633,
0.020590205,
0.0050568455,
-0.003906826,
-0.014525877,
0.011117933,
-0.0009767065,
0.023065176,
0.008448592,
0.009426919,
0.0029560355,
0.00042477826,
0.039366294,
0.010308061,
0.0046097958,
0.001635133,
-0.009388045,
-0.00993228,
-0.0040590824,
-0.0017493252,
0.026434246,
0.020447668,
-0.025514232,
-0.0028556113,
0.0026936368,
0.011746394,
-0.013346703,
0.0009669881,
0.01967019,
-0.027056228,
0.0029171617,
0.0065599694,
0.054786272,
0.014137139,
0.012271192,
-0.0053419205,
0.018387351,
-0.017635789,
-0.004101196,
0.021367682,
0.023117008,
0.011837101,
-0.011377092,
0.013398535,
-0.00065316237,
-0.008319013,
0.02621396,
-0.02094007,
0.020149633,
-0.0010593135,
0.013346703,
-0.0067122253,
0.010800463,
-0.0037837254,
-0.012433167,
-0.031176861,
0.020732742,
0.025656769,
-0.010891168,
-0.030114308,
-0.020849364,
-0.012186965,
0.014253761,
-0.011182723,
0.010703279,
-0.0021461628,
0.0034759738,
0.006997301,
-0.020408794,
-0.0108199,
0.016897185,
-0.0029430776,
0.021886,
0.0044186655,
0.0068677207,
-0.008059854,
-0.00948523,
-0.002074894,
0.032705903,
0.02056429,
-0.016003085,
-0.009115928,
-0.020642037,
-0.01431855,
-0.013489241,
-0.026058465,
0.0073147705,
-0.024581257,
0.010146086,
-0.0038420362,
0.01615858,
0.0011160047,
0.028300194,
0.016586194,
-0.009971153,
-0.023220671,
0.0022887003,
0.006789973,
0.035789896,
0.017104512,
0.004042885,
0.01648253,
-0.005542769,
0.016599152,
-0.0138779795,
-0.01617154,
0.028118782,
-0.02622692,
-0.0028475127,
0.020460626,
-0.008286618,
0.0024603934,
0.012951485,
0.026693406,
0.0041076746,
-0.026693406,
-0.019190745,
-0.012271192,
-0.013463325,
-0.01833552,
0.017221134,
0.03397578,
0.02170459,
-0.010314539,
0.01177231,
0.019825686,
0.027470883,
-0.026460163,
-0.025086619,
0.018633552,
0.00023101621,
0.0041854223,
-0.006394755,
-0.013826148,
0.0041271118,
0.022715311,
0.009031701,
-0.0014440031,
0.013268955,
0.008863247,
0.006210104,
-0.0012852681,
-0.025656769,
-0.009511146,
-0.003450058,
0.009627767,
-0.0005187235,
-0.025566064,
0.0058829156,
-0.00040777095,
-0.043797918,
-0.034157194,
0.009284381,
0.01278951,
0.015886463,
-0.0006474933,
0.0047361357,
-0.017609874,
-0.0005458542,
-0.015808716,
0.0036768224,
-0.0062846127,
-0.005264173,
-0.00464543,
-0.0033561126,
-0.025047744,
-0.024283225,
-0.0005324913,
0.004434863,
-0.011253992,
-0.018750174,
0.009025222,
0.017389588,
-0.0020846124,
-0.004302044,
-0.001037447,
-0.0035018898,
0.0549936,
-0.009692557,
-0.007554493,
-0.002285461,
-0.029803317,
0.0134244505,
0.016197454,
0.007165754,
-0.032213498,
-0.025488315,
0.013055149,
0.0077682994,
-0.010619052,
0.007943232,
0.005759815,
0.0038776707,
0.023194756,
-0.006524335,
0.013865022,
-0.011571462,
0.0031147706,
-0.011098497,
-0.031539686,
-0.02004597,
-0.016029002,
-0.018309603,
-0.0018238334,
0.011843579,
-0.00041344005,
0.005468261,
-0.00916776,
0.0016489009,
-0.0040558428,
-0.0062522176,
0.000028750483,
0.009439877,
0.029881066,
0.0051054377,
-0.0129126115,
-0.0012569225,
-0.010133128,
-0.035608485,
0.004742615,
0.016702816,
-0.014836869,
-0.010521866,
0.0019485538,
-0.008856769,
0.019968223,
-0.026019592,
-0.014292634,
-0.012277671,
0.046052605,
0.018037487,
-0.002431238,
-0.004039645,
-0.0070880065,
-0.009569457,
-0.008416197,
0.019100038,
-0.021056691,
-0.01056722,
0.00490135,
0.031721096,
-0.011564983,
0.0132819135,
-0.038355574,
-0.048670113,
0.027678212,
-0.0037221753,
-0.0027989203,
0.0059153107,
0.0061582723,
-0.027574547,
0.00044583494,
-0.02233953,
-0.04418666,
-0.006997301,
0.0026077903,
0.015199692,
0.021730505,
0.012523872,
-0.014422214,
-0.009977632,
0.03392395,
0.013463325,
-0.0135669885,
-0.014085307,
0.009239028,
-0.032939143,
0.033016894,
0.012886696,
-0.008370845,
0.029388662,
-0.004677825,
0.029751485,
-0.008293097,
-0.006504898,
-0.021419514,
-0.0009111068,
-0.035141997,
-0.04353876,
0.0035083687,
-0.027730044,
-0.0076905517,
-0.02941458,
0.0035375243,
0.017039722,
-0.010418203,
0.016858311,
0.009018743,
0.014966449,
-0.027730044,
0.010282145,
-0.025358737,
-0.002907443,
-0.0045806402,
-0.01698789,
-0.0068936367,
-0.008856769,
0.0141630545,
-0.0047199386,
0.020732742,
-0.008228308,
-0.0033723102,
-0.012938527,
-0.00015569804,
-0.029077671,
-0.00916776,
-0.02469788,
-0.03348338,
-0.00091353647,
-0.011253992,
-0.033016894,
-0.036930196,
-0.012264713,
-0.0031601235,
-0.015070112,
0.003404705,
-0.0125433095,
-0.024982955,
0.028015118,
-0.0017072117,
0.010042422,
-0.006802931,
0.039236717,
0.020473583,
0.017208176,
-0.028118782,
-0.020097801,
-0.024814501,
0.0025349017,
0.037889086,
0.016858311,
0.017026765,
-0.0051540304,
0.012964443,
0.014810953,
-0.013852064,
-0.026019592,
0.016016044,
-0.014823911,
0.014642499,
-0.0020846124,
-0.019890474,
-0.03703386,
0.020188509,
0.006307289,
0.019566527,
-0.01145484,
0.0030435019,
0.0004079734,
0.015653221,
-0.018918628,
0.01623633,
0.00040513885,
-0.028352026,
-0.020797532,
-0.010295102,
0.009776784,
-0.002074894,
-0.010418203,
0.01291909,
0.011506672,
0.006180949,
0.027678212,
-0.0048138835,
0.009297339,
0.002424759,
0.011085538,
0.04519738,
-0.0008025839,
-0.0070296954,
0.018594678,
-0.0027713845,
-0.0020101042,
0.016469572,
0.0051572695,
-0.028144699,
-0.042502124,
0.010781026,
0.021860085,
0.008435635,
-0.0008892403,
-0.0014861166,
-0.012763594,
-0.0070491326,
-0.021989666,
-0.020356962,
0.0095888935,
-0.040558428,
-0.017570999,
-0.012180486,
0.014759121,
0.023972234,
0.020965986,
0.003270266,
-0.016780563,
0.036956113,
-0.026421288,
0.007185191,
0.0127312,
0.0077164676,
-0.0035245663,
0.008429156,
-0.00617123,
-0.019981181,
0.020862322,
-0.0129968375,
-0.023700116,
-0.008020979,
-0.0048009255,
0.02303926,
0.03965137,
0.0020068646,
-0.0062910914,
0.026693406,
0.014227845,
-0.00859761,
-0.008344929,
-0.011169765,
-0.04449765,
0.005575164,
-0.0026304666,
-0.0040558428,
-0.029518243,
-0.013903895,
-0.0026272272,
0.008714231,
0.0002075299,
-0.018996375,
-0.016197454,
0.015743926,
-0.009854532,
0.003919784,
0.0013484381,
-0.012692326,
-0.018452141,
0.014435172,
0.005873197,
-0.0120897805,
-0.0072370227,
0.005520093,
0.0028863866,
0.011882453,
-0.0315656,
0.00092325493,
-0.02316884,
-0.040921252,
-0.024982955,
0.0038906287,
-0.032731816,
0.021341767,
0.023065176,
-0.005160509,
-0.024296183,
-0.017570999,
-0.035608485,
-0.033120558,
0.007917316,
-0.003621751,
-0.018944543,
0.024607174,
-0.013709526,
0.009498187,
-0.010444119,
0.005251215,
0.014797995,
-0.029621907,
0.009342692,
0.0019226379,
0.012102738,
0.0035278057,
-0.010858774,
-0.008552256,
0.04322777,
-0.01630112,
-0.005575164,
0.027133977,
-0.03397578,
0.021523178,
0.00082526036,
0.0046097958,
-0.011694563,
0.02933683,
0.026252836,
-0.030762207,
0.011882453,
0.015925338,
0.0007580409,
-0.0012447744,
0.010463556,
-0.013158812,
0.011234554,
0.006815889,
0.018024528,
-0.024296183,
-0.006796452,
-0.0012876977,
0.01623633,
0.020823449,
0.007651678,
0.019112997,
0.0074573085,
-0.0006478982,
-0.013670652,
-0.0020894718,
-0.01177879,
-0.0065146163,
-0.0009540301,
-0.0035116083,
-0.0076322407,
0.0031941382,
-0.009861011,
-0.015964212,
-0.019838642,
0.014759121,
-0.0009985731,
-0.025540147,
0.0040072505,
0.000910297,
-0.0122323185,
-0.0053807944,
-0.008759583,
-0.020162592,
-0.018931586,
-0.022196993,
0.0055589667,
-0.039314464,
-0.008876205,
-0.0069778636,
-0.011325261,
0.012608099,
0.0012042808,
-0.010955959,
-0.0009070575,
0.017648747,
0.18835697,
-0.0125433095,
-0.009880448,
0.0081116855,
0.03265407,
0.021471346,
0.012899653,
0.006725183,
-0.0004988816,
-0.020849364,
0.021367682,
0.008688315,
-0.010735673,
-0.0071527963,
0.005494177,
-0.016508447,
-0.012212881,
-0.0070296954,
-0.013016275,
-0.008701273,
0.012368376,
-0.007839568,
0.009575935,
0.0059347474,
0.016275203,
-0.010975395,
-0.00993228,
0.013839106,
0.028844427,
-0.0035602006,
-0.035427075,
0.019812727,
0.008493945,
0.014810953,
-0.0000073900887,
-0.0036379483,
-0.019838642,
-0.0016189356,
0.014085307,
-0.014331508,
0.004052603,
0.01234246,
0.0045223297,
-0.011824142,
0.0070361746,
0.0029382184,
0.00024680872,
-0.012128654,
0.02404998,
-0.002061936,
-0.037085693,
0.019449905,
0.032291245,
0.009873969,
-0.028507521,
0.00063979946,
0.023881529,
0.004480216,
-0.0013759738,
0.03099545,
-0.02145839,
-0.011681604,
-0.0104959505,
0.025786348,
-0.014642499,
0.026239878,
-0.012718242,
-0.0066344775,
0.026848901,
0.0043311995,
0.0019744697,
-0.0018416507,
-0.006404474,
0.002094331,
-0.015899422,
-0.033872116,
0.031539686,
0.015562515,
0.033872116,
0.022132203,
0.008487467,
0.017791284,
-0.030373467,
0.0019631316,
-0.020033013,
-0.020965986,
0.016936058,
0.0015687235,
-0.0041724644,
0.017856074,
0.0064563057,
0.0044154264,
-0.020862322,
0.0077812574,
0.0033463943,
0.016197454,
-0.0021834169,
0.010340455,
-0.015821675,
-0.012070344,
-0.013476282,
0.06981751,
-0.012893174,
0.020136677,
0.0073342077,
0.009329734,
-0.019255534,
0.004052603,
-0.0046875435,
-0.015108986,
0.019981181,
-0.041024916,
0.006161512,
-0.012977401,
-0.008811415,
0.018413266,
0.005066564,
-0.004065561,
-0.0016092171,
-0.0031277286,
-0.001725029,
-0.021886,
-0.0027924413,
0.016106749,
-0.0010115311,
0.01056722,
-0.028844427,
-0.0107551105,
-0.0073601236,
-0.011079059,
-0.0050114924,
0.007936753,
-0.016067876,
0.01615858,
-0.017091556,
-0.011422445,
-0.002316236,
-0.0019258774,
-0.01768762,
0.031228693,
0.003582877,
0.008921558,
-0.017000848,
0.019877518,
0.019877518,
-0.02227474,
0.026771154,
0.006180949,
-0.031176861,
-0.024879292,
-0.0137354415,
-0.018348478,
-0.017843116,
0.015160818,
0.034908757,
-0.018542847,
-0.016184498,
-0.020577246,
0.005484458,
0.024879292,
-0.01438334,
0.006333205,
0.032887314,
0.008040417,
-0.01762283,
0.0012577324,
-0.16161172,
0.004843039,
0.029129503,
-0.021678673,
0.020356962,
0.008247744,
0.013890938,
-0.01915187,
0.018763132,
0.005296568,
0.03812233,
0.002298419,
-0.027989203,
-0.008766063,
0.013210644,
0.007580409,
-0.014422214,
0.04276128,
0.020266255,
0.008027459,
0.013411493,
-0.011947243,
0.028352026,
0.012271192,
-0.011960201,
0.011934285,
-0.014746163,
-0.028533436,
0.0044899345,
-0.0041530277,
-0.004855997,
0.0027632858,
0.02220995,
-0.0040947166,
0.018814964,
-0.0039489395,
-0.0014626302,
-0.0005114346,
-0.020227382,
0.01597717,
0.042294797,
0.023609411,
0.028170614,
-0.0013921713,
-0.012212881,
0.0059671425,
0.0040817587,
0.005322484,
0.0054974165,
-0.008461551,
0.032161668,
0.0043895105,
-0.00048794833,
0.022546858,
0.015692094,
0.019449905,
0.009750868,
-0.0026499038,
-0.003169842,
0.009213112,
-0.00362823,
-0.0038744314,
0.0076063247,
-0.006206865,
-0.016599152,
-0.04175056,
-0.0042080986,
0.0072629387,
-0.026123255,
0.0015938296,
-0.020007096,
-0.016288161,
0.013722484,
-0.028818512,
0.02227474,
-0.0016529503,
-0.013489241,
0.00080177403,
0.01361882,
0.010638488,
-0.007366603,
-0.00078314694,
-0.026589742,
-0.011765831,
-0.0011994216,
0.019112997,
0.0046421904,
0.016119707,
0.0030192055,
-0.0057306597,
0.013631778,
-0.027600463,
0.022326572,
-0.014668415,
0.025604937,
0.011539067,
-0.021354726,
0.00897339,
-0.010308061,
-0.0016553799,
0.011040186,
-0.0061582723,
-0.011701042,
0.020447668,
0.032032087,
0.024386888,
0.0043052835,
-0.000859275,
0.03978095,
0.018827923,
-0.021095565,
-0.0027065948,
-0.0043052835,
0.013903895,
-0.014214886,
0.030243888,
-0.0042437334,
0.010223834,
-0.0016067876,
-0.038407404,
0.05644489,
0.0039359815,
0.01884088,
0.03247266,
0.0061906674,
-0.034649596,
-0.12843934,
-0.032420825,
0.026874818,
0.008105206,
-0.023764906,
-0.0033496337,
-0.0021591207,
0.013579946,
-0.03965137,
0.03055488,
-0.0225339,
-0.036774702,
-0.017596915,
-0.0038452758,
0.0036573852,
-0.01858172,
0.012899653,
-0.020551331,
0.0044769766,
0.0392108,
-0.015860548,
0.010301582,
0.023726033,
-0.01609379,
0.0029770923,
-0.010657925,
-0.036437795,
0.014823911,
0.00060861936,
0.0071398383,
-0.0017169302,
0.0012050907,
0.017713537,
-0.016974933,
-0.016210413,
-0.004843039,
-0.0042566913,
-0.017998612,
0.05416429,
0.02526803,
0.00079003087,
0.0068677207,
0.017493252,
0.013307829,
0.011765831,
-0.03073629,
-0.032498572,
0.000017057944,
0.034520015,
-0.026434246,
-0.02647312,
-0.026589742,
-0.032498572,
0.00037395876,
0.0018497494,
-0.02393336,
-0.0023632087,
0.019488778,
0.009789742,
-0.009679599,
-0.021212187,
-0.014927574,
0.014810953,
0.032058004,
0.024840416,
0.003195758,
-0.0066474355,
-0.0397032,
0.024101812,
0.008169997,
-0.00007476138,
-0.011934285,
-0.023427999,
-0.0034144234,
-0.027600463,
-0.007664636,
-0.012355419,
-0.017661706,
0.009465793,
-0.016339993,
-0.012932048,
-0.02119923,
0.028092867,
-0.021432472,
0.033509295,
0.001126533,
0.020279214,
-0.001228577,
0.014214886,
-0.0037124567,
0.0059315083,
0.037915003,
-0.011079059,
-0.008733667,
-0.0030694178,
-0.00598334,
0.012595141,
-0.025591979,
0.008545778,
0.0421393,
-0.012374856,
-0.009128885,
-0.055874743,
0.016443657,
0.0025154648,
-0.0034079445,
0.020058928,
-0.008506903,
-0.008714231,
-0.011817663,
0.0073471656,
0.025319861,
-0.0060189744,
0.024153644,
-0.009115928,
0.005264173,
-0.006945469,
-0.017039722,
0.026952565,
-0.011986117,
-0.011558504,
0.016754648,
0.006777015,
-0.011370613,
0.014564752,
-0.002826456,
0.0026304666,
-0.010878211,
-0.020978944,
0.023790821,
-0.014979406,
0.0007815272,
0.024892248,
-0.03439044,
-0.015614347,
0.009899884,
-0.005801928,
-0.008176476,
0.0018934825,
0.027574547,
0.025384651,
0.024166603,
-0.0040493635,
-0.029855149,
0.001120864,
0.004849518,
0.0023875048,
0.0036379483,
-0.01929441,
0.0046745855,
-0.0023745468,
0.005416429,
0.013094023,
0.018167065,
-0.010962438,
-0.026084382,
-0.021873044,
-0.017026765,
-0.013826148,
-0.014461088,
-0.010463556,
-0.023531662,
0.008461551,
0.007580409,
-0.0005134593,
0.02564381,
-0.005925029,
-0.018231856,
-0.039547708,
0.0010350174,
-0.008435635,
-0.03322422,
-0.0187113,
-0.0006163132,
-0.0035925955,
0.012102738,
0.013411493,
-0.015951253,
-0.022715311,
-0.01527744,
0.007198149,
0.03164335,
0.0059477054,
0.025125492,
-0.016923102,
0.004088238,
0.019423988,
-0.010541304,
-0.0015930197,
0.007463787,
-0.007943232,
-0.005643193,
0.009128885,
0.015730968,
0.022469109,
0.010470035,
0.007327729,
0.006751099,
-0.0063882763,
0.0026936368,
-0.011713999,
0.0245683,
0.0019177786,
-0.005212341,
0.014344466,
-0.0010269186,
-0.013903895,
0.016793521,
-0.033301968,
-0.018814964,
-0.026524952,
-0.001896722,
0.009375087,
0.007567451,
0.011875974,
-0.005876437,
-0.02679707,
0.0053030467,
0.004606556,
-0.00464543,
-0.023259545,
0.043357346,
0.011189202,
0.003971616,
-0.00757393,
0.006245739,
0.018037487,
0.006122638,
0.024840416,
-0.028922176,
0.03348338,
-0.0073147705,
0.00074670266,
-0.011428924,
-0.035919476,
-0.0005333012,
-0.004632472,
-0.013450366,
0.0010342075,
0.014124181,
-0.0225339,
0.084485926,
-0.00096374855,
-0.023583494,
-0.008785499,
-0.007204628,
0.017739452,
0.000432877,
0.020473583,
-0.030399384,
-0.023181798,
-0.010275666,
-0.025864096,
0.01903525,
-0.027600463,
-0.0135669885,
0.011461319,
-0.017363671,
0.0040104897,
0.016080834,
0.004004011,
0.013774316,
-0.0028053992,
-0.003098573,
0.029673738,
-0.027678212,
-0.0031018127,
0.02539761,
0.004606556,
0.0077164676,
-0.048851524,
0.0035666795,
-0.00083092944,
-0.040454764,
-0.0052479752,
0.014487004,
-0.0087077515,
0.0033042808,
-0.028611185,
0.019320324,
0.037889086,
0.016961975,
0.0067705363,
-0.019423988,
-0.039832782,
0.00025085808,
-0.006223062,
0.008545778,
-0.0076775937,
0.0027082146
] |
Trypanosoma brucei causes human African trypanosomiasis and regularly switches its major surface antigen, VSG, in the bloodstream of its mammalian host to evade the host immune response. VSGs are expressed exclusively from subtelomeric loci, and we have previously shown that telomere proteins TbTIF2 and TbRAP1 play important roles in VSG switching and VSG silencing regulation, respectively. We now discover that the telomere duplex DNA-binding factor, TbTRF, also plays a critical role in VSG switching regulation, as a transient depletion of TbTRF leads to
|
[
-0.029999534,
-0.018029343,
0.002773745,
-0.034846857,
0.0067020953,
0.024842523,
-0.031346012,
0.003446984,
-0.013922584,
-0.01700602,
0.00844915,
0.004204378,
0.01635971,
-0.006008659,
0.00066229893,
0.00089288334,
0.020224102,
-0.01635971,
-0.0043188287,
-0.023401791,
-0.03078049,
0.003184421,
-0.0057225325,
-0.010367882,
-0.0015795872,
0.0055643213,
0.0010115417,
-0.02903007,
-0.033500377,
0.010064924,
0.0072979117,
-0.008657855,
-0.02967638,
0.004635251,
-0.0025566255,
-0.016103879,
0.004662181,
-0.007910559,
0.018056272,
-0.02120703,
0.007291179,
0.027266184,
-0.010657375,
0.01140467,
-0.003339266,
0.00073172676,
0.018689116,
-0.003894688,
-0.031938463,
0.007971151,
0.0033964913,
0.004544364,
-0.025233,
0.00609618,
-0.011411402,
-0.00599856,
0.006806447,
0.0006782884,
0.02185334,
-0.03842849,
-0.011243093,
-0.012818472,
-0.030430406,
-0.012131768,
-0.0057393634,
0.015026697,
0.0022974284,
0.012636698,
-0.0061668702,
0.010078389,
0.0438144,
0.031696096,
0.005426307,
-0.010273629,
0.022163032,
-0.03589711,
-0.025515761,
0.024896381,
0.007318109,
0.010946868,
0.030995928,
-0.009129122,
-0.01695216,
0.016063485,
0.027656661,
0.005220969,
0.0046217865,
0.00788363,
0.017436892,
-0.0070824753,
0.00111926,
0.01638664,
0.011633571,
0.019604722,
-0.015309457,
-0.008927151,
-0.0022856467,
0.030107252,
-0.017275315,
-0.011875938,
-0.009176249,
-0.025138747,
0.010919938,
-0.014043768,
-0.008408756,
0.011754755,
-0.0029538365,
-0.009297431,
0.001772302,
-0.022742016,
-0.042360205,
0.04069057,
-0.010866079,
-0.04693823,
0.017019484,
0.01579419,
0.012939655,
0.006133208,
-0.0029386887,
0.008913686,
0.026767986,
0.0119230645,
0.0011142107,
-0.008987742,
0.04017891,
0.018729512,
0.006577546,
-0.005948067,
-0.01345805,
-0.016184667,
0.019510468,
0.024088494,
0.0037701388,
-0.010940135,
0.0077422494,
-0.010354417,
-0.034227476,
-0.008105799,
-0.011081516,
-0.01326281,
0.021409003,
0.034766067,
-0.016857907,
-0.01599616,
0.016736723,
0.016373174,
0.0046958425,
0.020479932,
0.016534751,
0.015188274,
0.0002932798,
-0.02010292,
0.015982697,
-0.012555909,
0.009984136,
0.010859347,
-0.0016485943,
0.039074797,
-0.021610975,
-0.014555429,
-0.005305124,
0.004285167,
0.02280934,
0.005978363,
0.02773745,
0.037916824,
-0.021274356,
0.013660021,
0.0053960113,
-0.016709795,
-0.010805488,
0.021866806,
-0.026081283,
0.025152212,
-0.013814867,
0.012683825,
0.012024051,
0.0041404204,
-0.010751628,
-0.023940383,
-0.0005032462,
0.013646556,
0.028464548,
0.008886756,
-0.018244779,
0.007782644,
0.010098587,
-0.016790584,
0.031830743,
-0.018716047,
0.012650163,
0.0018867526,
0.025421508,
-0.016090414,
-0.63295245,
-0.020883877,
0.015915371,
-0.00898101,
0.012407796,
-0.007526813,
0.026700662,
-0.004234674,
-0.04130995,
0.023778806,
-0.017194526,
0.010314023,
0.018756442,
-0.035223868,
-0.0064832927,
-0.036974292,
-0.010765093,
0.004907913,
0.041013725,
-0.008085602,
-0.008435686,
0.010098587,
-0.0035244066,
0.02954173,
0.007284447,
-0.0092233755,
0.025192607,
-0.03161531,
-0.0104554035,
0.041229162,
-0.006240926,
0.017719653,
-0.009512869,
-0.016763654,
0.05178555,
-0.011384473,
0.0015518161,
0.0149459075,
0.03341959,
0.027077677,
-0.012932923,
0.0010107002,
0.009021404,
0.0056417435,
-0.007042081,
0.026485225,
0.011788417,
0.013188754,
0.01576726,
-0.012737684,
0.016709795,
-0.0021005059,
-0.030968998,
0.016777119,
0.015484499,
0.0012715803,
0.011478727,
-0.04524167,
0.023563368,
-0.015969232,
-0.03635491,
0.016332781,
0.033231083,
-0.015390245,
-0.0048978142,
0.005773025,
0.004557829,
0.034308266,
0.008206785,
0.0013330134,
0.021045454,
0.02410196,
-0.0052041383,
0.017746583,
0.0042212093,
0.0337966,
-0.008428954,
0.011781684,
-0.00875884,
0.007641264,
0.00012433884,
0.004409716,
-0.013666754,
-0.007284447,
0.00864439,
-0.02182641,
-0.024936777,
0.010246699,
-0.013855261,
0.0011891086,
0.008408756,
0.022943988,
-0.013700415,
-0.006803081,
-0.0273739,
0.031103646,
0.02900314,
-0.00046958428,
-0.0053892788,
-0.01982016,
-0.0060591516,
-0.018635258,
0.00242871,
-0.026431367,
0.009250306,
0.002255351,
-0.034362122,
0.008018278,
0.046561215,
-0.023751875,
-0.021193566,
-0.005860546,
-0.00083313335,
-0.00399904,
0.009048333,
-0.013215683,
0.030968998,
0.01140467,
0.002341189,
-0.037378233,
0.0059547997,
0.018514074,
-0.0050896876,
-0.015134415,
0.028518409,
0.021449398,
0.012252951,
-0.02433086,
-0.0062846867,
-0.020372216,
-0.01841982,
0.004251505,
0.025488833,
-0.022715086,
0.02843762,
0.006133208,
0.02472134,
0.024802128,
-0.011377741,
-0.022513116,
-0.0030177943,
-0.010152445,
0.010973797,
0.0015526577,
-0.01236067,
-0.021139707,
-0.012266416,
-0.013383993,
0.0092233755,
-0.010448671,
0.040502064,
-0.0077085877,
0.0032248152,
-0.009331094,
0.011243093,
-0.025556156,
-0.022459256,
-0.023603763,
-0.003635491,
0.00920991,
0.015295993,
-0.003807167,
-0.0070353486,
0.005220969,
-0.012515515,
-0.010556389,
0.012461656,
0.0016603759,
0.0019204145,
-0.033688884,
0.019214245,
-0.02280934,
-0.010845882,
0.024829058,
-0.014353458,
0.028841563,
-0.004059632,
0.010287093,
-0.014313064,
-0.01281174,
-0.020614581,
0.003426787,
-0.010415009,
-0.013559035,
0.03632798,
0.0066415034,
0.02069537,
0.019470075,
0.028302971,
0.03018804,
-0.009640784,
-0.010307291,
-0.033688884,
0.014690077,
0.018998807,
-0.0152690625,
0.02903007,
0.025838917,
-0.007728785,
0.024371255,
0.006974757,
-0.0040024063,
0.006698729,
-0.027925957,
0.0166694,
-0.016265456,
-0.0016511189,
-0.0044130823,
0.008765573,
0.011620107,
0.013437852,
-0.0010233234,
-0.008179855,
0.007748982,
0.016804047,
-0.0017807174,
0.0076547284,
0.005052659,
0.01157298,
-0.018365962,
-0.018891089,
-0.005988462,
0.013128162,
-0.021274356,
-0.008913686,
0.02675452,
-0.0059547997,
0.016871372,
-0.004197646,
-0.0070016864,
-0.0018850694,
-0.00060633593,
-0.009519601,
0.0083279675,
0.01669633,
-0.014286133,
0.007816306,
-0.010664107,
0.021839876,
-0.0003932137,
0.0055946168,
0.00971484,
0.0014945908,
0.012454923,
0.013451317,
0.023724945,
0.009425348,
-0.008496277,
-0.01841982,
0.02838376,
-0.025179142,
0.002687907,
-0.014905513,
0.004685744,
0.007836503,
-0.007351771,
-0.0042313077,
0.021153172,
0.027629733,
0.004584758,
0.02773745,
0.0040831952,
0.00038732286,
-0.015444105,
0.012623233,
0.006803081,
-0.021759087,
-0.017140668,
0.008947347,
0.011007459,
-0.025973564,
-0.006735757,
0.011748022,
-0.033069503,
0.015686471,
0.005698969,
0.0010426791,
-0.015161345,
-0.0004430755,
-0.0034840123,
0.000973672,
-0.01920078,
0.016884837,
0.018258244,
-0.011896134,
-0.035412375,
-0.013976444,
-0.0028595831,
0.0031305617,
0.04015198,
0.028249113,
0.003514308,
0.010017797,
0.0114316,
-0.011498923,
-0.0024590057,
0.027602803,
-0.015497964,
0.0064664613,
-0.018271709,
0.0023849495,
0.031749956,
-0.018500611,
-0.0026424634,
0.028922351,
0.0123337405,
-0.011694163,
0.0044063497,
0.0023630692,
-0.003820632,
0.0060423207,
-0.02683531,
-0.004049533,
-0.02534072,
0.0074325595,
0.018500611,
-0.0044837724,
0.0010006016,
0.0035715334,
0.0022435694,
-0.037324376,
-0.02371148,
0.0054296735,
-0.018298639,
0.026081283,
0.029083928,
-0.010287093,
0.017585006,
0.0065708137,
0.021476327,
-0.006988222,
-0.03455063,
0.034362122,
-0.022768946,
-0.012919459,
-0.008927151,
0.0010696086,
-0.011445065,
0.018567935,
0.027683591,
0.0066044754,
-0.025488833,
0.001292619,
0.015471035,
0.0076277987,
-0.0007472954,
0.007748982,
0.040502064,
0.004339026,
0.0058369827,
-0.012091374,
0.013289739,
0.0044736736,
-0.02097813,
-0.013229148,
-0.002994231,
0.005840349,
0.043491244,
0.00015905274,
-0.045537893,
0.0027451324,
0.020964665,
0.016117344,
0.0045544626,
0.0072575174,
0.025677338,
0.009364756,
-0.004362589,
0.0039519137,
-0.008893488,
-0.010859347,
-0.008866559,
-0.00516711,
-0.012603036,
0.03883243,
-0.016130809,
-0.015376781,
-0.020816553,
-0.0011226262,
-0.015578752,
-0.008543404,
0.0046487157,
-0.017760048,
-0.022284213,
0.006836743,
-0.027548945,
-0.0016469111,
-0.00092065445,
0.006446264,
-0.010273629,
0.011700896,
-0.011397938,
-0.02536765,
-0.02626979,
0.02043954,
-0.0407175,
-0.01855447,
0.0067222924,
0.015632613,
0.022203425,
-0.0008752108,
-0.019119991,
0.005890842,
-0.00039573835,
-0.030511195,
-0.021651369,
0.021395538,
-0.039101727,
0.015524893,
-0.010637178,
0.035008434,
-0.008893488,
-0.017369568,
0.0031103645,
-0.006564081,
0.018352497,
0.02128782,
0.010886276,
0.0025364284,
0.008092334,
0.020089455,
0.025663875,
-0.0010409959,
-0.002925224,
0.0038542938,
-0.034173615,
-0.013350331,
-0.026404437,
0.0058268844,
0.00008136726,
-0.0000575935,
-0.024398185,
-0.0149459075,
-0.026875705,
0.00007642316,
-0.012576106,
-0.01314836,
0.002930273,
0.044056766,
0.003443618,
0.0084895445,
0.0027182028,
-0.014757401,
-0.015726864,
-0.014245739,
-0.021301284,
0.02289013,
0.016184667,
-0.009775432,
0.016548216,
0.027414296,
-0.017046414,
-0.00335778,
-0.012690557,
-0.008146193,
0.036193334,
0.023361396,
-0.008368362,
-0.018675653,
-0.007270982,
-0.009660981,
-0.000057698693,
0.008469348,
-0.01033422,
-0.020587651,
0.0030565055,
0.0043087304,
-0.0063924054,
0.009411883,
-0.028976211,
-0.0050088987,
0.013828331,
-0.003135611,
-0.010374614,
-0.020897342,
-0.0014281084,
-0.018850695,
-0.008866559,
-0.02954173,
-0.038724713,
-0.013020444,
0.0009778797,
0.034362122,
0.026081283,
0.03710894,
-0.00299928,
0.019900948,
0.023469115,
0.016453963,
0.012724219,
0.0004180394,
0.020628046,
-0.029326295,
0.020022132,
0.008159658,
-0.00991008,
0.00111926,
-0.008146193,
0.025502296,
0.008011545,
-0.01852754,
-0.016480893,
0.012858867,
-0.030484267,
-0.0059716306,
0.03088821,
-0.0060894475,
0.012609769,
-0.044810794,
-0.005473434,
0.03280021,
0.011647036,
-0.0017251752,
0.018514074,
0.019927878,
-0.014326528,
0.0119230645,
-0.015942302,
0.006355377,
-0.0025869212,
-0.007728785,
0.0051401807,
-0.0024522734,
0.02255351,
-0.0074796863,
-0.010320756,
0.005793222,
-0.00015989429,
0.0029420548,
0.02376534,
-0.015471035,
-0.03253091,
-0.017988948,
0.006150039,
-0.02593317,
-0.032342408,
-0.01767926,
-0.047342174,
-0.011700896,
0.025071424,
-0.014878584,
0.024802128,
0.0021005059,
-0.019968271,
0.029918745,
0.012764613,
0.03212697,
0.0036489558,
0.029110858,
0.02097813,
-0.0046217865,
-0.027266184,
-0.0006433641,
0.019698976,
-0.0052613635,
0.009539798,
0.01483819,
0.0051637436,
-0.021947594,
0.018796835,
0.012475121,
-0.02601396,
-0.028545337,
0.0075537427,
-0.026512155,
-0.0039182515,
-0.006873771,
-0.01193653,
-0.011593177,
0.031938463,
-0.033204153,
0.013242613,
-0.012475121,
-0.027441226,
-0.015363316,
0.0087386435,
0.0011689113,
0.023576833,
-0.011357543,
-0.023886522,
-0.023953848,
-0.005988462,
-0.0065472503,
0.000585718,
-0.00009662033,
0.032342408,
0.0017857667,
-0.005268096,
-0.0019204145,
0.0032012518,
0.005665307,
-0.0018850694,
0.0041808146,
0.0469113,
-0.031049786,
0.0045746597,
0.009122389,
0.008960812,
-0.0019927877,
0.005284927,
0.007506616,
0.00089961576,
-0.0056888703,
-0.018069737,
0.015821118,
0.03282714,
-0.016602077,
0.0046083215,
-0.016198132,
-0.01979323,
-0.02157058,
-0.026189001,
0.014259204,
-0.045376316,
-0.0048338566,
-0.0034570827,
0.021920664,
0.023159426,
0.010340952,
0.0036287587,
-0.008395292,
0.047153667,
-0.033581167,
-0.0073450385,
0.003409956,
0.0013380627,
-0.025556156,
-0.0050964197,
-0.005180575,
-0.03401204,
0.018487146,
-0.020426074,
-0.014016838,
-0.019308496,
0.0016443864,
0.030403478,
0.00740563,
-0.041067585,
0.037836038,
-0.015699936,
0.03212697,
-0.008731911,
-0.0013447951,
0.031022858,
-0.006887236,
-0.0013389043,
0.002770379,
-0.021489792,
-0.0116739655,
0.010394812,
-0.011128643,
0.009977403,
-0.0149459075,
-0.0052714623,
0.015026697,
-0.0046790116,
-0.008873291,
-0.010287093,
0.003598463,
-0.005180575,
-0.012017318,
0.017773513,
-0.013936049,
-0.027548945,
-0.025744664,
0.0008937249,
-0.02843762,
-0.0030834351,
-0.0021089215,
0.022270748,
0.005005533,
-0.033958178,
-0.035493165,
-0.0037061812,
-0.025515761,
0.021435933,
-0.0022368368,
0.0018850694,
0.003409956,
-0.012098107,
-0.046668936,
0.016602077,
0.016063485,
0.033177223,
0.01819092,
0.009593657,
-0.009135854,
-0.008597263,
-0.00022574548,
0.029999534,
0.016602077,
-0.01514788,
0.006008659,
0.020453004,
0.011337346,
0.027495084,
-0.04389519,
0.0031962027,
0.038563136,
-0.013989909,
-0.030699702,
0.018365962,
-0.021085849,
0.024546297,
-0.009580192,
0.0043188287,
-0.02748162,
-0.0053421524,
0.023846129,
-0.023253677,
-0.0026643437,
-0.0013717246,
0.0089002205,
-0.015511429,
-0.01126329,
0.0009071897,
0.011801882,
0.021031989,
-0.020856947,
-0.00554749,
0.007284447,
-0.025946634,
0.01695216,
0.02781824,
0.0120105855,
0.006200532,
0.010556389,
0.009640784,
-0.0015602316,
0.009526333,
-0.034281336,
-0.0028175055,
0.0010191157,
0.0068603065,
-0.00067702605,
0.0015560238,
0.00799808,
-0.019941341,
0.009432079,
-0.015026697,
-0.04020584,
-0.045484032,
0.014676612,
0.010300558,
-0.0033173857,
-0.012535712,
-0.0023580198,
-0.030349618,
-0.018541005,
0.006028856,
-0.003169273,
0.00602549,
0.020318355,
-0.006755954,
-0.011875938,
-0.014259204,
-0.01638664,
0.014636218,
-0.02043954,
-0.009142587,
0.17956632,
-0.011007459,
0.0049887015,
0.029110858,
-0.013518641,
0.002462372,
0.010630446,
-0.015511429,
0.015053626,
0.012939655,
0.018769907,
-0.000727519,
-0.014972838,
0.0014954323,
-0.0014163267,
-0.011222895,
-0.029891815,
0.0005974997,
-0.025098354,
-0.018608328,
0.015228668,
-0.012273149,
-0.005937969,
-0.008509742,
0.035600882,
-0.0009585242,
-0.021974524,
-0.011586444,
0.0052108704,
0.0055508562,
-0.0364357,
-0.010859347,
0.0028982942,
0.0058639124,
-0.005305124,
0.012784811,
-0.0066078417,
-0.020210637,
0.012555909,
0.01973937,
-0.022486186,
0.0149459075,
-0.016655935,
-0.021678299,
-0.011835543,
0.005217603,
0.0023664355,
-0.021489792,
-0.003377977,
0.01635971,
-0.037943754,
0.014097626,
-0.00782977,
0.019443145,
0.020749228,
0.0052647297,
0.028599197,
0.0003290456,
-0.005160378,
0.027131535,
-0.0034705475,
0.023549903,
-0.039532598,
0.044137556,
-0.006540518,
0.049092595,
-0.008859826,
0.016009625,
0.036166403,
-0.024034636,
-0.0053084902,
-0.017248385,
-0.014111091,
-0.0054330393,
-0.003615294,
-0.019860553,
0.016198132,
-0.00822025,
0.03032269,
0.027845168,
0.0053960113,
-0.011781684,
-0.020816553,
-0.0016553266,
-0.012273149,
-0.028922351,
0.024882916,
0.011707628,
-0.00799808,
-0.0047463356,
0.0147843305,
0.00019934188,
-0.010960332,
-0.012892528,
-0.0015779041,
-0.0008903587,
0.0068131797,
-0.0028377029,
0.019564329,
-0.031399872,
-0.030618913,
0.05978363,
0.015699936,
0.012724219,
-0.0027518647,
0.006819912,
0.00378697,
0.0022873299,
0.006843475,
-0.012151966,
0.012441458,
-0.006678532,
-0.0013826648,
-0.0067761512,
0.009984136,
0.013666754,
0.019523934,
-0.016453963,
0.04386826,
-0.009627319,
0.0053892788,
-0.02131475,
0.0071497993,
0.029218577,
-0.01695216,
-0.011465262,
-0.0049718707,
0.016830977,
-0.007021884,
-0.023536438,
0.0025482099,
0.003219766,
-0.005833617,
0.004130322,
0.0045006033,
-0.015080555,
0.010172643,
-0.010058192,
-0.01388219,
0.01731571,
-0.00036965034,
-0.009950474,
0.0060221236,
-0.0025044493,
-0.018823765,
-0.03150759,
0.018998807,
0.010556389,
-0.0077557145,
0.004584758,
-0.02407503,
-0.012259684,
0.005769659,
-0.0026828577,
0.015161345,
-0.031884603,
-0.006092814,
-0.04615727,
0.008361629,
0.010771826,
-0.0371628,
0.010327487,
0.026512155,
-0.017827371,
0.0039485474,
0.01692523,
-0.17019485,
0.00495504,
0.0028814634,
-0.024600156,
0.033715814,
0.016494358,
0.033446517,
-0.003992308,
-0.023751875,
0.026741058,
0.027279649,
0.014272668,
-0.053616762,
-0.02503103,
0.0001547398,
-0.03129215,
-0.028626127,
0.019672045,
0.027104605,
-0.005921138,
0.007930757,
-0.026189001,
0.0065573486,
-0.015699936,
-0.004739603,
0.01481126,
0.0061197435,
-0.0012900945,
0.008927151,
-0.015955767,
-0.01821785,
0.014703542,
0.030484267,
-0.029891815,
0.01816399,
-0.0016982456,
-0.014892049,
0.0022991116,
-0.0076345312,
0.016629005,
0.02497717,
0.0075335456,
0.0045712935,
-0.0084895445,
-0.008314502,
0.040502064,
-0.010428473,
-0.010260164,
-0.000286337,
0.003962012,
0.011593177,
-0.001965858,
0.018339032,
0.028922351,
0.015619147,
-0.031130577,
0.0058773775,
0.005668673,
0.018541005,
0.005823518,
-0.023374861,
-0.023536438,
0.034766067,
0.0013540521,
-0.0018985342,
-0.014461176,
-0.024317397,
0.00068375847,
-0.0043693217,
0.028653055,
-0.017948555,
0.000038448263,
0.00020281327,
-0.016763654,
0.0023294073,
0.027441226,
-0.019295033,
0.0028343366,
-0.014568894,
-0.002687907,
-0.01337726,
0.0061736023,
-0.023953848,
0.0027350339,
-0.011909599,
0.0185814,
-0.0017335906,
0.011875938,
-0.010603515,
-0.0062274616,
0.002258717,
-0.02621593,
0.0035412377,
-0.018514074,
0.034254406,
0.022513116,
-0.00076959643,
-0.008011545,
0.0025448438,
0.02185334,
0.02376534,
-0.019214245,
-0.029891815,
0.030968998,
0.03457756,
-0.0047766315,
-0.0138014015,
0.006129842,
0.055421043,
0.009735038,
-0.019416215,
0.009943741,
-0.001740323,
0.015255597,
0.006426067,
0.028841563,
-0.001945661,
-0.006823278,
0.011000726,
-0.013424387,
0.07292526,
-0.0045611947,
-0.00038458782,
0.017692724,
-0.0185814,
-0.022284213,
-0.13615587,
0.0012959853,
0.004837223,
0.001094855,
-0.014757401,
0.008179855,
-0.0011083198,
0.023846129,
0.0049516736,
0.009041601,
-0.02781824,
-0.013532106,
-0.00037932815,
-0.019631652,
0.0011394572,
0.012077909,
0.005974997,
0.0033342165,
-0.02159751,
0.03280021,
0.0011790099,
0.0038475613,
-0.020681905,
-0.0030632378,
0.0041033924,
-0.0023327735,
-0.025313789,
0.0065371515,
0.0016065168,
0.0060692504,
-0.013269543,
-0.023294073,
0.022176495,
0.008092334,
-0.02781824,
-0.009492671,
-0.017786976,
-0.0340659,
0.022230355,
-0.0129800495,
-0.026162071,
0.007937489,
0.02348258,
0.002911759,
0.008543404,
-0.005305124,
-0.017611934,
0.00010345791,
0.026566014,
-0.019039202,
-0.023536438,
-0.03263863,
-0.046642005,
-0.042764146,
0.029218577,
-0.023294073,
0.0057460954,
0.036758855,
-0.017867766,
0.004820392,
-0.011687431,
0.0021005059,
0.0061399406,
-0.0031053154,
0.026619874,
-0.007136334,
-0.0036220264,
-0.03148066,
0.03832077,
-0.014043768,
0.0014087528,
-0.010657375,
-0.026404437,
-0.024936777,
-0.01751768,
0.014865119,
-0.017369568,
-0.018406358,
-0.01627892,
-0.019645117,
-0.0015678055,
-0.012300078,
0.005288293,
-0.018662188,
0.029083928,
0.009869685,
-0.0030767026,
-0.0018160625,
-0.0037230123,
-0.01543064,
0.004312096,
0.03253091,
-0.015848048,
-0.028787704,
0.0007426669,
0.013303204,
0.0023159424,
-0.014097626,
0.009896615,
0.019254638,
-0.013538838,
-0.028276041,
-0.06382307,
0.009788896,
0.004739603,
-0.010590051,
0.0035244066,
0.00095347484,
0.009701375,
-0.013383993,
-0.024048101,
-0.007109405,
-0.004719406,
-0.0009332777,
-0.024950242,
0.0002123859,
-0.024155818,
-0.02964945,
0.034954574,
-0.0054296735,
0.022970919,
0.031184435,
-0.013787936,
-0.0028057238,
-0.014676612,
0.023805734,
-0.0029168085,
0.008375094,
-0.0071699964,
0.035735533,
-0.025152212,
-0.0026390972,
0.012448191,
-0.038697783,
-0.0146227535,
-0.013155092,
-0.008375094,
0.00447704,
-0.007769179,
0.026404437,
0.016682865,
0.029110858,
-0.020654975,
-0.022311144,
0.018352497,
-0.003807167,
0.01312143,
0.009068531,
-0.0273739,
0.013013712,
0.01129022,
-0.0046689133,
-0.0018446752,
0.010987262,
-0.004443378,
-0.01129022,
-0.008455883,
-0.017800441,
-0.011498923,
-0.00971484,
0.0011647036,
-0.016548216,
0.018500611,
0.02469441,
0.0017975484,
-0.007950954,
0.0020365482,
0.008287573,
-0.015444105,
-0.002512865,
0.006816546,
-0.015134415,
-0.010825684,
0.029757168,
0.01154605,
0.014030303,
-0.006143307,
0.013491712,
-0.004443378,
0.008321235,
-0.02224382,
0.012232754,
-0.0038711247,
-0.0071901935,
-0.021260891,
0.01050253,
0.024142355,
-0.0018278442,
-0.0035513362,
0.026431367,
0.0043457584,
-0.013720613,
-0.02260737,
0.016063485,
0.0168983,
0.009829291,
0.015161345,
0.01109498,
0.0007270982,
0.012629965,
0.020129848,
0.033769675,
-0.014515035,
0.00038900596,
0.00328709,
0.0068670386,
-0.02035875,
0.04087908,
-0.017477287,
-0.026983423,
0.0115123885,
-0.0095599955,
0.013828331,
0.0059144055,
0.008563601,
0.000088993795,
0.0035176743,
0.020776158,
-0.014353458,
-0.0030211604,
-0.022324609,
0.012650163,
0.025233,
0.033069503,
-0.0022671327,
0.000878577,
0.004254871,
0.0014735521,
0.02753548,
-0.017719653,
-0.002580189,
-0.021045454,
0.01314836,
-0.0023984143,
-0.026162071,
-0.00464535,
-0.0050661243,
-0.0063789403,
-0.012542444,
0.02097813,
-0.018298639,
0.07610295,
0.029272435,
-0.008368362,
0.00021185992,
-0.030538125,
0.011586444,
-0.0009341192,
0.031911533,
-0.037728317,
-0.02649869,
0.023267142,
-0.0345237,
0.017396498,
-0.027360437,
-0.034254406,
0.03280021,
-0.017477287,
0.0057595605,
-0.012885796,
-0.0030295758,
0.03145373,
-0.011714361,
0.016871372,
0.029272435,
-0.021018524,
-0.002807407,
0.03506229,
0.011115178,
-0.018756442,
-0.025233,
-0.008779038,
-0.017894695,
-0.017854301,
-0.010940135,
0.0086645875,
-0.007116137,
-0.022338074,
-0.015013232,
0.02182641,
0.0071699964,
-0.0015964182,
-0.000355344,
-0.018742977,
-0.025919706,
0.022566974,
0.0062644896,
-0.016103879,
-0.018473681,
-0.003945181
] |
Metastatic melanoma is a rapidly progressing disease with high mortality rate and limited treatment options. Immunotherapy based on tumor-targeting cytotoxic T cell responses represents a promising strategy. To assist in its development, we examined the possibility and efficacy of using CD4+ cytotoxic T cells. The regulatory mechanisms controlling CD4+ T cell-mediated cytotoxicity were also investigated. We found that naturally occurring granzyme B and perforin-expressing CD4+ cytotoxic T cells can be recovered from metastatic melanoma patients at significantly elevated frequencies compared to those from healthy controls. These CD4+ cytotoxic T cells were also capable
|
[
-0.03048899,
-0.011890968,
-0.0027619207,
-0.037915125,
0.0041641267,
0.008302105,
-0.036503114,
-0.009805636,
-0.042229604,
-0.0087793125,
0.013571,
0.01763707,
0.003997431,
-0.022382999,
-0.017297141,
0.019807385,
0.05465008,
0.0065142107,
-0.011328778,
-0.006318098,
-0.02792645,
0.005262358,
0.0021196515,
-0.0031606834,
0.009080019,
0.023206672,
-0.0056022867,
-0.06589387,
0.0008326619,
-0.0010434831,
-0.0021196515,
-0.003709799,
-0.013204923,
0.018552262,
0.0017977,
-0.023912678,
0.016564988,
-0.014028597,
0.012610048,
0.013034958,
-0.012766938,
0.0011578822,
0.027612671,
-0.010707755,
-0.0015190564,
0.0095768375,
0.0055761384,
-0.026710553,
-0.016813397,
0.01669573,
0.0447137,
0.014538489,
-0.011662169,
-0.0025625394,
-0.014237784,
-0.018591486,
0.0014929081,
0.029469205,
0.0031034837,
-0.026187586,
-0.008557051,
-0.008981963,
-0.008713942,
0.042778723,
0.015440608,
0.01579361,
-0.008210585,
0.017754737,
0.0010557402,
-0.011047683,
0.022631409,
0.027874155,
-0.014956864,
0.005448665,
0.027534226,
-0.0075568766,
-0.009125778,
0.0055826753,
-0.011158814,
0.0075372653,
0.023324339,
-0.023468155,
-0.015623647,
0.04487059,
0.021807734,
0.002972742,
-0.0025037057,
-0.004592306,
0.013335665,
-0.006857408,
0.012237433,
0.019506678,
0.027194297,
0.034097463,
-0.010308992,
0.023834232,
-0.0076745446,
0.037287567,
0.013531778,
-0.02291904,
0.009047333,
0.006197162,
-0.014878418,
-0.01822541,
-0.03082892,
0.009805636,
0.011936728,
0.009236909,
0.021559324,
-0.009426485,
-0.028789347,
0.024919389,
-0.009112705,
-0.037339862,
0.019166749,
0.02329819,
0.0012150818,
-0.002062452,
-0.026004547,
-0.0073999865,
0.0050204857,
0.010060582,
0.028161786,
-0.015152976,
0.031717964,
-0.0066024614,
-0.012060932,
-0.02539006,
-0.004141247,
0.0070208353,
0.033103827,
0.013924003,
0.0073999865,
0.0055369157,
0.0010050777,
0.009276131,
-0.0243572,
-0.0031149236,
-0.021990772,
-0.012400861,
-0.001869608,
0.03718297,
0.020003498,
0.011688318,
-0.016028946,
0.011995561,
0.040634554,
0.009446096,
-0.0005532013,
0.007282319,
-0.031508777,
-0.022840595,
-0.014891492,
-0.0279526,
0.006233116,
-0.021363212,
0.00041285812,
0.031534925,
-0.03051514,
-0.01651269,
-0.0075568766,
-0.010184787,
0.021873105,
-0.015296792,
0.006046809,
0.027246594,
0.010014823,
0.017153326,
-0.017349439,
-0.0055663325,
-0.0070208353,
0.027194297,
-0.0037424844,
0.024174161,
-0.034908064,
0.01476075,
0.001372789,
0.009733728,
-0.012531603,
-0.002732504,
-0.006347515,
0.027612671,
0.0064292285,
-0.0072692446,
-0.01738866,
0.0034613896,
0.022683704,
-0.00905387,
-0.0070273723,
-0.05112005,
0.0036607708,
0.012322416,
0.0004567792,
-0.02251374,
-0.6229586,
-0.028004896,
0.0235466,
0.002936788,
-0.013263757,
0.034045167,
0.015336014,
-0.004464833,
-0.015296792,
0.0070992806,
-0.0048112986,
0.023180524,
0.008818535,
-0.042203456,
-0.01819926,
-0.03318227,
-0.016643433,
-0.0050270227,
-0.0011480765,
-0.0068181856,
-0.009491855,
0.0012387787,
-0.011851746,
0.01213284,
-0.023049781,
0.0114072235,
0.021925403,
-0.018813746,
-0.011348389,
0.04311865,
-0.024553312,
0.02826638,
-0.011080368,
-0.0060860314,
0.05064938,
0.007766064,
-0.008217123,
0.010871181,
-0.0131657,
0.022618333,
-0.013440259,
0.004500787,
0.04165434,
0.010439734,
-0.020421872,
0.018316928,
0.00022083109,
-0.00698815,
0.0053081177,
0.0023026902,
0.013845558,
0.019545902,
-0.024657905,
0.0058474275,
-0.0002735364,
-0.0018892192,
0.018526115,
-0.0042687203,
-0.00496492,
-0.012224359,
0.0055467216,
0.009178075,
-0.0044452217,
-0.04275257,
-0.022696778,
0.0040628016,
-0.011511817,
0.016434247,
-0.006863945,
0.012629659,
0.0146300085,
0.02716815,
0.0020542808,
0.0037326787,
0.017715516,
0.03318227,
-0.0010083462,
-0.018656857,
-0.003266911,
0.005147959,
-0.0016514325,
-0.019219046,
-0.015113753,
0.0071777254,
0.011727541,
-0.008910054,
-0.019389011,
0.01691799,
0.016264282,
0.02970454,
0.031508777,
0.001714352,
-0.009236909,
-0.03302538,
-0.02235685,
0.016682655,
0.012028247,
-0.0024465062,
-0.004775345,
-0.025298541,
-0.019284418,
-0.012257045,
0.03927484,
-0.0049191606,
0.021467805,
0.0022144394,
-0.06374971,
-0.004226229,
0.033103827,
-0.02716815,
0.0020314008,
-0.003853615,
0.002559271,
-0.013531778,
0.009890618,
-0.016578062,
0.0073999865,
0.02010809,
0.008275957,
-0.02242222,
0.028292527,
-0.007648396,
0.010210936,
0.005981438,
0.01860456,
-0.000412041,
-0.005089125,
-0.038699575,
0.011217647,
0.0047132424,
-0.009178075,
-0.002013424,
0.019415159,
-0.01114574,
0.02448794,
-0.0010884256,
0.015139902,
0.0034090928,
-0.0016416269,
-0.017310215,
-0.030410545,
-0.009701042,
0.008727016,
0.004709974,
0.00019529558,
0.01876145,
-0.0006655575,
-0.0026769387,
0.00078363373,
0.0042948686,
0.02329819,
0.010505104,
0.012466232,
0.026645182,
0.044007692,
-0.010485494,
-0.0066318787,
-0.029338462,
0.013675594,
-0.008079844,
0.012995736,
0.0023043244,
-0.013139552,
0.008347865,
0.0014242686,
-0.01982046,
0.017336365,
0.029573798,
-0.0017927971,
-0.040373072,
-0.021912327,
-0.029992172,
-0.019768162,
0.022932114,
0.0040889503,
-0.00658285,
-0.019153675,
-0.024906315,
-0.0017535746,
0.01321146,
0.012047858,
-0.012093618,
0.020644132,
-0.009066945,
0.021729289,
0.010629309,
0.03383598,
0.0019284417,
-0.011335315,
0.03720912,
-0.014041671,
0.012871532,
-0.013714816,
0.023964975,
0.00991023,
-0.036921486,
-0.0039582085,
0.018905265,
-0.0024939,
0.036660004,
-0.0052460153,
-0.020526465,
0.011649095,
-0.009093093,
-0.001869608,
-0.000033911158,
0.000826942,
-0.014080893,
0.017297141,
0.005497693,
0.01033514,
-0.0060108546,
-0.00017394789,
-0.014067819,
0.022226108,
0.001558279,
0.005850696,
-0.015375237,
-0.002936788,
-0.023847306,
0.0069750757,
0.006318098,
-0.0057559083,
-0.016094318,
-0.026135288,
-0.0016530668,
0.008746628,
0.0076745446,
0.009485318,
-0.0026687672,
-0.0040660705,
-0.004837447,
0.022317627,
0.011452983,
0.028554011,
0.003709799,
0.019676642,
-0.0095768375,
0.048165284,
-0.0021588742,
-0.01644732,
0.0117733,
-0.0015590962,
0.017192548,
-0.018970637,
0.0015999529,
0.0064945994,
0.0069816126,
0.00006312378,
0.020683356,
-0.0109561635,
0.001175042,
-0.01763707,
0.005925873,
0.011760226,
-0.021245545,
0.0023108616,
0.010916942,
0.045419704,
0.013649445,
0.022814447,
-0.02107558,
0.01028938,
-0.021140952,
0.0044811754,
0.010753514,
-0.0003916126,
0.0093545765,
-0.0025151456,
0.002534757,
-0.026069917,
-0.0069423905,
0.051826056,
-0.024540238,
0.0035169548,
0.026802072,
-0.004700168,
-0.0012878069,
0.014355451,
0.0039876252,
-0.030279804,
-0.041575897,
0.0126754185,
-0.00572976,
-0.0037784383,
-0.019742014,
-0.02792645,
0.009635672,
0.004553084,
0.019271344,
0.010315529,
0.022252256,
-0.022605259,
0.0062363846,
-0.0053146547,
-0.024121864,
0.03336531,
-0.01114574,
0.029129276,
0.0033698701,
0.012257045,
0.005599018,
-0.009805636,
-0.012453157,
0.029443055,
0.016865693,
-0.021127878,
-0.022866743,
-0.03211019,
-0.024409497,
-0.010374363,
0.008151752,
0.005291775,
-0.025363911,
0.008687793,
0.0058474275,
0.00734769,
0.012080544,
0.008145215,
-0.011609873,
-0.005958558,
-0.013845558,
0.013440259,
-0.012034784,
0.03386213,
0.033156123,
0.0012175331,
0.005327729,
0.00462826,
0.012328953,
-0.007432672,
-0.008687793,
0.031011958,
-0.020617984,
0.005540184,
0.009897156,
-0.007066595,
0.008485144,
0.006576313,
0.018892191,
-0.009439559,
-0.008681256,
-0.0037490216,
0.012440084,
0.014930715,
-0.0009356211,
0.042857166,
0.0027047212,
0.02514165,
-0.0070273723,
0.018068518,
0.021977698,
-0.0052362094,
-0.018173112,
0.0030789697,
0.020474168,
0.0038732262,
0.01788548,
-0.027429633,
-0.032031745,
0.0025069742,
0.008439384,
0.0070273723,
-0.005605555,
0.0055173044,
0.014839196,
0.003345356,
0.006255996,
0.016002798,
-0.015453682,
0.009485318,
0.019938126,
-0.011426834,
-0.04165434,
0.027272742,
-0.004334091,
-0.011341852,
-0.025782285,
-0.010197861,
0.01213284,
-0.012145914,
-0.001696375,
-0.011779837,
0.020814097,
0.0037653642,
-0.027246594,
0.01053779,
-0.006700518,
-0.024592536,
0.0127865495,
-0.03341761,
0.0015893301,
-0.021154026,
-0.016878769,
0.014342377,
-0.02460561,
-0.010799274,
0.024540238,
0.0026164704,
0.005082588,
0.0076745446,
-0.008145215,
-0.0006390006,
0.030855067,
-0.011028072,
0.008981963,
-0.013074181,
-0.042360347,
0.013113404,
-0.019493604,
-0.010367826,
-0.018316928,
-0.042438794,
0.007445746,
-0.008766239,
-0.021049432,
0.0041020242,
0.00838055,
-0.007635322,
-0.003860152,
0.01022401,
0.027691117,
0.006082763,
-0.0058768443,
-0.014525415,
-0.0069750757,
-0.020016572,
-0.04259568,
-0.010903867,
-0.024566386,
0.015401386,
0.0127930865,
-0.0077595264,
-0.006690712,
0.009779488,
-0.013780187,
0.005317923,
-0.031404182,
0.01476075,
0.0215724,
-0.0112960925,
0.012825772,
0.005383294,
-0.0079687135,
0.002966205,
-0.028109489,
0.03208404,
0.0044386843,
0.0036542336,
-0.0029155423,
-0.008256345,
-0.024958612,
-0.031090403,
-0.0183823,
-0.0044811754,
-0.0018450938,
0.0062658014,
-0.03174411,
-0.020866394,
-0.008517829,
-0.005232941,
0.018146964,
0.014211635,
-0.035823256,
-0.021977698,
0.029207721,
-0.01788548,
-0.01064892,
0.019650495,
-0.03592785,
-0.0134794805,
0.014015523,
0.0065959245,
0.0018091399,
-0.00055483554,
-0.0010361288,
-0.017153326,
0.012283193,
-0.028083341,
-0.032868493,
0.0073150042,
0.01469538,
0.047197793,
0.045445856,
0.022736002,
-0.0051741074,
0.021781586,
0.020016572,
0.005899724,
0.005275432,
-0.011858283,
0.029260017,
0.0211671,
0.013636371,
-0.000020402873,
-0.017061807,
0.022304554,
-0.008132141,
0.0093480395,
0.004700168,
-0.012577362,
-0.026775923,
0.0021310914,
-0.010119417,
-0.04615186,
0.03545718,
-0.0076222476,
-0.00017262004,
-0.03462043,
-0.014486193,
0.032607008,
0.026710553,
0.012708104,
0.016185837,
0.03399287,
-0.01064892,
-0.016225059,
-0.008367476,
0.0088839065,
-0.008563588,
-0.014996086,
-0.008105992,
0.00038425837,
0.01206747,
0.00074236834,
-0.011021535,
0.033940576,
-0.013780187,
0.0068966304,
0.0043308227,
-0.036137037,
-0.008687793,
-0.02132399,
-0.018669931,
-0.030724326,
-0.001144808,
-0.0051414217,
-0.015453682,
-0.011747152,
0.009165001,
-0.024579462,
0.0153098665,
-0.0131330155,
-0.014250858,
0.036058594,
0.014120116,
0.008727016,
-0.011283019,
-0.0008972157,
0.010949627,
-0.0053048492,
-0.008177901,
-0.0127930865,
0.0015713532,
-0.0018859507,
0.02595225,
0.032371674,
-0.01741481,
-0.013806336,
0.015924353,
0.013924003,
-0.015479831,
-0.028031046,
0.01444697,
0.011439908,
0.013185312,
-0.027874155,
-0.021585474,
-0.02682822,
0.014316228,
-0.009413411,
0.008609348,
0.010681606,
-0.013453333,
-0.037888978,
0.032816194,
-0.0062265787,
-0.003559446,
-0.0039484026,
-0.022827521,
0.0024612145,
-0.017218696,
-0.004716511,
0.011387612,
-0.014656157,
0.014551564,
-0.00023656097,
0.0049714576,
0.02610914,
-0.005974901,
0.02291904,
-0.011537965,
0.007818361,
0.04434762,
-0.0034613896,
0.012407398,
0.0215724,
-0.0026458874,
-0.0015860617,
-0.019049082,
0.008844684,
-0.0111849625,
-0.011204573,
-0.015741315,
0.01923212,
0.02069643,
-0.009047333,
0.006543628,
-0.018669931,
-0.00021184259,
-0.026802072,
-0.006903168,
0.016081244,
-0.025416208,
0.0065240166,
-0.004141247,
-0.0040628016,
0.024474867,
0.008001399,
-0.00054666423,
-0.011086905,
0.03652926,
-0.016316578,
0.012387787,
0.018003147,
0.010276306,
-0.014041671,
0.003781707,
-0.008753165,
-0.029103128,
0.009949452,
-0.008589737,
-0.034463543,
-0.033129975,
-0.013296442,
-0.0005303215,
0.007373838,
-0.02376886,
0.027037406,
0.03017521,
0.016891843,
0.008060233,
-0.015636722,
0.030462842,
-0.023533527,
-0.012701567,
0.028815495,
-0.004059533,
-0.02195155,
0.00862896,
0.00039202115,
-0.0003491215,
-0.01772859,
-0.011348389,
-0.037104525,
-0.0015607304,
0.008713942,
0.00008283719,
-0.02217381,
-0.0030185017,
-0.02595225,
-0.0011734078,
0.022396073,
-0.013440259,
-0.0056676576,
0.0067855,
0.0014692111,
0.0147346025,
-0.027586522,
-0.010420122,
-0.01779396,
-0.019062156,
-0.016081244,
-0.017532477,
-0.015780536,
0.043563172,
-0.009165001,
0.013087256,
-0.03561407,
0.010184787,
-0.050021816,
-0.009707579,
0.018343076,
0.03577096,
-0.009812173,
0.021507028,
-0.029678391,
-0.0022798104,
-0.010701218,
0.0030315758,
-0.009746802,
-0.029364612,
0.024278754,
-0.0044027306,
0.030436695,
-0.026749775,
-0.017610922,
-0.014904567,
0.03527414,
-0.012949976,
-0.0021180173,
0.027534226,
-0.017349439,
0.0074588205,
-0.01022401,
0.000007213782,
-0.012250508,
0.007295393,
0.031665668,
-0.032162488,
-0.0048701325,
0.027769562,
-0.009446096,
0.022683704,
-0.007635322,
0.006033735,
0.008962351,
0.0066547585,
-0.014917641,
-0.036686152,
0.0054780818,
-0.016826471,
0.002265102,
0.027848005,
-0.00905387,
0.0014332571,
-0.009518004,
-0.014603861,
-0.012028247,
0.0055597955,
-0.011224184,
0.006707055,
-0.0133618135,
-0.0037915125,
-0.016055094,
0.0033306477,
0.021245545,
-0.015270644,
-0.0043765823,
0.0009249983,
0.0028550744,
-0.038568836,
0.01750633,
0.024867093,
-0.0065893875,
-0.0073019303,
0.0093480395,
-0.023716565,
-0.028841645,
-0.002354987,
-0.004693631,
-0.008132141,
0.0005507499,
-0.010328603,
-0.000323586,
0.010982312,
-0.0028910283,
-0.013316054,
-0.022722928,
0.018748377,
0.19109224,
-0.030279804,
-0.0110738315,
0.013427184,
-0.004285063,
-0.011917116,
0.0044190735,
-0.0071058176,
0.0063671265,
0.0072561707,
0.038568836,
-0.012531603,
-0.0021016747,
-0.002703087,
0.02060491,
-0.001594233,
-0.025154725,
-0.007282319,
-0.0031198265,
-0.012309342,
-0.0023288385,
0.00091682695,
0.010982312,
0.0063867373,
0.0055663325,
0.0036280854,
-0.009674894,
0.022932114,
0.0069097048,
0.0028142175,
-0.024187235,
-0.008295568,
0.005154496,
-0.001959493,
0.01619891,
0.008766239,
-0.030593583,
-0.027115852,
0.007439209,
-0.01579361,
-0.022252256,
0.022879817,
-0.036921486,
-0.0022226109,
-0.009106168,
0.020068869,
-0.005102199,
0.010014823,
-0.008184438,
-0.0075372653,
-0.03820276,
-0.022579111,
0.019022934,
0.010478957,
0.0028142175,
0.008210585,
0.025808433,
0.00480803,
0.0008865929,
0.0102697695,
-0.024043418,
-0.0126754185,
-0.025416208,
0.028004896,
0.011747152,
0.012394324,
-0.012623122,
0.006125254,
0.023651194,
-0.013701742,
-0.0052394783,
0.0056611206,
-0.010746977,
0.0013760576,
0.008596274,
-0.01810774,
0.005801668,
0.005412711,
0.021873105,
0.010426659,
0.0122178225,
0.008713942,
-0.0029956219,
0.00038711834,
-0.01372789,
-0.035640217,
0.011217647,
0.021284766,
-0.0263314,
-0.0033224763,
-0.003961477,
-0.011093443,
-0.0050727823,
0.009491855,
0.01748018,
0.025298541,
0.0119890245,
0.0028420002,
0.0032227857,
-0.026370624,
-0.033260718,
0.058833815,
0.019545902,
0.0018565337,
0.009132315,
0.01017825,
-0.018277705,
0.00734769,
-0.012034784,
-0.018460743,
0.01094309,
-0.03333916,
0.015806684,
-0.0016596039,
-0.022566037,
0.023533527,
-0.01579361,
-0.0124466205,
0.008027547,
-0.014721528,
0.012910754,
-0.04583808,
-0.0048537897,
0.035797108,
-0.006030466,
0.002307593,
-0.03302538,
-0.0047720764,
-0.0070077614,
-0.016264282,
-0.022056144,
-0.006409617,
0.012453157,
0.010054045,
0.0009838322,
-0.012649271,
0.01988583,
-0.014198561,
-0.036032442,
0.0044681015,
-0.002732504,
-0.009596449,
-0.0013450064,
0.005383294,
0.0028142175,
0.013178775,
-0.001642444,
0.020997135,
-0.022382999,
-0.038725726,
-0.011917116,
-0.04612571,
-0.0139370775,
-0.016146613,
0.042386495,
-0.003709799,
-0.002564174,
-0.015087605,
-0.0035757886,
0.01644732,
-0.027011259,
0.021337064,
0.015179125,
-0.007635322,
-0.015532128,
-0.0060533457,
-0.16170147,
-0.0031721233,
0.015806684,
-0.015872056,
0.035901703,
-0.013126478,
-0.010753514,
-0.005484619,
-0.005112005,
0.0060893,
0.034594283,
0.004644603,
-0.03558792,
-0.011276482,
-0.002559271,
0.009426485,
0.0034254354,
0.03804587,
0.039693214,
0.0061579393,
0.015492905,
-0.014996086,
0.013270294,
-0.030070618,
0.0032080773,
0.010733902,
-0.0023844037,
-0.020264981,
-0.011387612,
-0.008995037,
-0.010073656,
0.0043667764,
-0.00057567254,
-0.01591128,
0.017205622,
0.0023893067,
0.004955115,
-0.02732504,
-0.0039712824,
0.010420122,
0.0391441,
0.0052950433,
0.0057624453,
-0.011165351,
-0.023520453,
0.017610922,
0.0074588205,
0.008864295,
0.032685455,
-0.010145565,
0.03305153,
-0.0044419533,
0.0036215482,
0.0070339097,
0.025873804,
0.018774524,
0.028449418,
0.006778963,
0.014538489,
0.013276831,
0.0031999059,
-0.013355277,
0.0046968996,
0.01074044,
0.0020722577,
-0.046047267,
0.0064292285,
0.025246244,
-0.007288856,
0.0016587868,
-0.054179408,
0.012623122,
0.026069917,
-0.013610222,
0.03258086,
0.011341852,
0.0053800256,
0.0287632,
0.010008286,
0.0053440714,
-0.012989199,
0.009825247,
-0.015453682,
-0.0061448654,
0.0024121865,
0.0011039511,
0.011060758,
0.0215724,
-0.013845558,
-0.003428704,
-0.002518414,
-0.0012485844,
0.010040971,
-0.027272742,
0.025586173,
0.024422571,
-0.013270294,
-0.022722928,
-0.00009351104,
-0.008177901,
0.028998533,
-0.01804237,
-0.017140253,
0.008236734,
0.014120116,
0.003015233,
-0.019519752,
0.011132665,
0.026305253,
-0.008870832,
-0.024710203,
0.013302979,
0.010825422,
-0.0066253413,
0.0074588205,
0.0033960186,
0.009648746,
-0.016734952,
0.006556702,
-0.010073656,
0.07311082,
0.0018107741,
-0.00026842928,
0.014355451,
-0.014107042,
-0.033731386,
-0.13869092,
-0.011701392,
0.018146964,
0.0052231355,
-0.009066945,
0.009178075,
0.0025380254,
0.033548348,
-0.029103128,
0.015937427,
-0.014120116,
0.0069097048,
-0.006180819,
-0.0029678391,
0.007288856,
-0.0021850225,
0.02729889,
0.0012338759,
-0.03341761,
0.025220096,
0.014786899,
-0.003968014,
-0.022605259,
-0.0013883146,
0.0138194095,
0.008354402,
-0.0113026295,
0.02539006,
0.01285192,
0.025272392,
0.025599247,
0.012577362,
0.04154975,
-0.0035332975,
-0.018421521,
0.023245893,
-0.019598197,
-0.01885297,
0.028344825,
-0.013080718,
-0.015872056,
0.019768162,
-0.002840366,
-0.00032767167,
0.007151577,
-0.010681606,
-0.03927484,
0.0036575021,
0.033888277,
-0.011524891,
-0.020147312,
-0.026501365,
-0.03639852,
-0.006517479,
-0.0039876252,
-0.01289768,
-0.0035627144,
0.015466756,
-0.024370274,
-0.0051414217,
0.013002274,
-0.020434946,
0.006922779,
-0.0017731858,
0.025050132,
0.0008661645,
-0.0132506825,
-0.021467805,
0.013740964,
-0.02586073,
0.0018026028,
-0.008955814,
-0.025586173,
-0.027351188,
-0.0102697695,
0.009132315,
-0.0013531777,
-0.004026848,
0.013067644,
-0.037392158,
-0.028998533,
-0.015597498,
0.014316228,
0.005638241,
0.033496052,
-0.014956864,
0.01089733,
-0.0012028246,
0.0101586385,
-0.01779396,
-0.0053473404,
0.061867025,
-0.021977698,
-0.0033731388,
0.002979279,
-0.0011856648,
-0.0075307284,
0.0019268075,
0.020892542,
0.050387893,
-0.0047263163,
-0.018735303,
-0.055382233,
0.019428233,
-0.0013809603,
0.0026458874,
0.01660421,
-0.015061457,
0.008485144,
-0.0043667764,
0.035221845,
0.01485227,
-0.0026981842,
0.013185312,
-0.024461793,
0.0055107675,
-0.016107392,
-0.0049518463,
0.012518529,
-0.008047159,
0.008530904,
0.0430925,
-0.018081592,
-0.00795564,
0.015113753,
-0.0017977,
0.0132506825,
0.012616585,
-0.0062788757,
0.036189333,
-0.008341327,
-0.026658256,
0.015061457,
-0.012342027,
-0.021363212,
-0.0029711076,
-0.017127177,
-0.026880518,
-0.005497693,
0.019519752,
0.007713767,
0.036973786,
0.000929084,
-0.0295215,
0.01810774,
0.00030703898,
-0.009328429,
-0.012655808,
-0.018343076,
0.012185137,
0.00024166807,
-0.009439559,
0.027246594,
-0.0018467281,
-0.002745578,
-0.04408614,
-0.009714116,
0.025494654,
-0.0071842624,
-0.020905616,
-0.024461793,
-0.027194297,
0.003536566,
0.020238834,
-0.0006071323,
0.020957913,
0.024906315,
-0.015767463,
-0.035221845,
0.0021065774,
0.010596624,
-0.0055892123,
-0.012453157,
0.015061457,
0.007511117,
-0.02132399,
-0.0033126706,
-0.023533527,
-0.02892009,
0.0073999865,
0.009034259,
0.022579111,
0.017702442,
0.011243796,
-0.020160388,
-0.0036967248,
0.039248694,
0.007890268,
-0.007733378,
0.015505979,
-0.00037915126,
-0.0072430964,
-0.0005662755,
0.014865344,
0.0037359472,
0.0055761384,
-0.0015067994,
0.02229148,
0.010302455,
0.026096066,
0.013296442,
0.0447137,
0.0068247225,
-0.0060893,
0.010910404,
0.0044092676,
-0.0055173044,
0.024501016,
-0.025939176,
-0.037444454,
-0.025337763,
0.013296442,
0.020278055,
0.013531778,
-0.00196603,
-0.011668707,
-0.029756837,
0.014878418,
0.006239653,
-0.015270644,
-0.027717264,
0.03307768,
0.009812173,
0.0093545765,
0.024056494,
-0.008713942,
-0.0014888224,
-0.004262183,
0.012989199,
-0.012773475,
0.012139377,
-0.011152277,
0.030802771,
-0.01525757,
-0.033129975,
-0.008197512,
-0.003945134,
-0.026318327,
0.020709503,
0.002042841,
0.023402784,
0.06348822,
0.009040796,
-0.016708804,
0.012342027,
-0.023651194,
0.017990073,
0.019205973,
0.024082642,
-0.038072016,
-0.04100063,
0.042046566,
0.0027063554,
0.02939076,
-0.036973786,
-0.016238132,
0.03258086,
-0.012753864,
0.0033829445,
0.0153098665,
-0.0019954469,
0.0073084673,
-0.003608474,
-0.015872056,
0.014996086,
-0.032188635,
-0.004602112,
0.013754039,
0.013139552,
-0.013688668,
-0.012296268,
0.0051904498,
-0.020487241,
-0.035404883,
-0.017205622,
0.0019137333,
-0.03956247,
-0.018813746,
-0.01810774,
-0.004902818,
0.028109489,
-0.0075438027,
0.031064255,
-0.008563588,
-0.020500315,
0.0030495527,
-0.020787949,
-0.03464658,
-0.023507377,
0.00005505456
] |
Hepatitis C virus (HCV) is a leading cause of liver cancer and cirrhosis, and Egypt has possibly the highest HCV prevalence worldwide. In this article we use a newly developed Bayesian inference framework to estimate the transmission dynamics of HCV in Egypt from sampled viral gene sequences, and to predict the public health impact of the virus. Our results indicate that the effective number of HCV infections in Egypt underwent rapid exponential growth between 1930 and 1955. The timing and speed of this spread provides quantitative genetic evidence that the Egyptian HCV epidemic was initiated and propagated by extensive antischistosomiasis injection campaigns
|
[
-0.005100151,
-0.008433217,
0.0025138108,
-0.029539337,
-0.021191837,
-0.0016146083,
-0.042805664,
0.018448899,
-0.029908579,
0.0010343713,
-0.008683774,
0.007918916,
-0.0016978525,
0.008354094,
0.002428094,
0.020624787,
0.032203153,
-0.01933244,
0.015560901,
0.0075101126,
-0.033600997,
-0.004071549,
0.01980718,
-0.016774124,
0.001292346,
0.044071637,
0.008802459,
-0.026374407,
-0.0092178555,
-0.011545397,
-0.0011324511,
0.0016121357,
-0.017947786,
0.0070815287,
0.0026440343,
-0.012184977,
0.0068573463,
-0.008070569,
0.023697406,
0.00915192,
0.020717097,
0.010925598,
-0.014004811,
0.019833555,
-0.0011003073,
0.015600462,
0.017908223,
-0.0026028245,
-0.007622204,
0.024857879,
0.03845389,
0.017182928,
-0.01933244,
-0.005136416,
0.010661854,
0.01740711,
-0.0154817775,
0.00019925041,
0.012053104,
-0.018185154,
0.0072463686,
0.0006713111,
-0.038269266,
-0.000489987,
-0.008242003,
0.035394456,
-0.010167334,
0.013780628,
-0.012376191,
0.030673437,
0.048977274,
0.04201443,
-0.015719147,
-0.0014967476,
0.0025121623,
0.0011720128,
-0.020387417,
-0.0025962307,
-0.015653212,
0.008162879,
0.02542493,
-0.009554129,
-0.0041473755,
0.013483916,
0.02527987,
0.00531774,
0.008031007,
0.038427513,
0.004951795,
-0.011097033,
0.01905551,
0.009376102,
-0.017789539,
0.011387151,
-0.009264011,
-0.008907956,
0.0041275946,
0.019226944,
-0.00008504716,
-0.04523211,
-0.009006861,
0.0067650354,
-0.015165284,
-0.007219994,
-0.010332175,
0.019081885,
-0.0030973447,
0.01219157,
0.025016125,
-0.022972109,
-0.010048649,
0.047183815,
0.007787044,
-0.024093023,
0.016681813,
-0.0019335737,
0.02183801,
0.007325492,
0.020334668,
-0.025767796,
-0.00768814,
0.019688496,
0.0045792568,
-0.008921144,
-0.00208193,
0.012567406,
-0.041566066,
-0.0072265877,
0.0026077696,
-0.001415976,
0.02500294,
-0.009620065,
0.008452998,
0.021534704,
-0.021139087,
0.03966711,
-0.031702038,
-0.021574266,
-0.038216516,
-0.026479905,
-0.017051054,
0.029829456,
0.0014019646,
0.015283969,
-0.0027462353,
0.02268199,
0.017380735,
0.011426712,
-0.008459591,
-0.0025863403,
0.01645763,
-0.008525527,
0.02811512,
-0.0092178555,
-0.008565089,
0.00042982044,
-0.0052781785,
0.0060595204,
-0.009475006,
-0.03995723,
-0.0096002845,
-0.019701682,
-0.001905551,
-0.0062078764,
0.020783033,
0.023222666,
0.012837743,
-0.0015890581,
-0.0007702151,
-0.010576137,
-0.01872583,
0.018936824,
-0.011097033,
0.01914782,
0.0052715847,
0.005891383,
-0.010866256,
0.016787311,
-0.021020403,
-0.030673437,
-0.025635924,
0.03373287,
0.047394812,
0.0073584598,
-0.018976387,
-0.011901451,
0.026901897,
-0.00957391,
0.007536487,
-0.025583176,
0.0048660785,
0.014677358,
0.0017506013,
-0.019635746,
-0.6464895,
-0.03230865,
-0.014519111,
0.0070155924,
0.012336629,
-0.006247438,
0.016299384,
0.006478214,
-0.026334846,
0.033521872,
-0.018884076,
0.0042693573,
0.009837654,
-0.011472868,
0.00025488393,
-0.01740711,
-0.013701505,
0.007655172,
-0.004272654,
0.0077936375,
-0.015455403,
0.008670587,
-0.00508037,
0.027745876,
0.014242181,
0.036001068,
-0.0035836226,
-0.015745522,
0.012560812,
0.021547891,
0.00026395012,
0.03811102,
-0.026110664,
0.004440791,
0.05042787,
-0.010114585,
0.013411387,
-0.00025632628,
0.0057265433,
0.04475737,
-0.010773946,
-0.024106208,
0.019965427,
0.013431167,
-0.010951973,
0.014110308,
0.030409692,
-0.017090617,
0.006557337,
-0.01848846,
-0.008235409,
0.010958566,
-0.022141315,
-0.0073980214,
-0.006540853,
-0.01909507,
0.008558495,
-0.043623272,
0.013009177,
-0.0054397215,
-0.0033231755,
0.037662655,
-0.0009000267,
-0.020545663,
-0.0009486545,
-0.0046451925,
-0.015125723,
0.0106882285,
-0.00589468,
0.0071276836,
0.013714693,
0.019174194,
0.00018039683,
-0.018237904,
0.022180878,
0.023697406,
0.01735436,
-0.03201853,
-0.02235231,
-0.004295732,
-0.0013368528,
-0.0057891826,
-0.028827228,
0.0050243246,
0.011822328,
-0.013596008,
-0.019490687,
0.0023786419,
0.005512251,
0.023024859,
0.011848703,
0.007971665,
-0.00818266,
0.0033610887,
-0.0011860242,
0.041012205,
-0.015389467,
-0.0033610887,
0.014703733,
0.0031055866,
-0.025200747,
-0.027851375,
0.009554129,
-0.020308293,
0.023552347,
0.009956339,
-0.030778933,
-0.0042858412,
0.04763218,
-0.036449432,
0.009989307,
-0.020070925,
-0.006273812,
-0.0071144965,
0.031807534,
-0.018198341,
0.00070551544,
0.013846564,
0.011308027,
-0.024976565,
0.009329947,
0.013259734,
0.0012404213,
-0.026875522,
0.0013566336,
0.023499597,
0.006125456,
-0.030567938,
-0.020057738,
0.015152098,
0.011321215,
-0.009402476,
0.028721731,
-0.01072779,
0.02764038,
-0.029038223,
0.026216162,
0.0106882285,
-0.022049004,
-0.016286196,
-0.025635924,
-0.0143344905,
-0.0032836138,
0.012448721,
-0.0037418692,
-0.0110706575,
-0.016510379,
0.00037480507,
-0.005499064,
0.0020753362,
0.015402654,
-0.013457541,
-0.0023555644,
0.027825,
-0.0022500667,
0.0060067712,
0.022114942,
-0.012119041,
0.00090579607,
-0.0147169195,
0.02189076,
0.038823128,
0.0087760845,
0.006577118,
-0.00990359,
0.005113338,
0.038875878,
0.001823131,
-0.013358638,
-0.020506103,
0.0111893425,
-0.003860554,
0.0010055243,
0.04301666,
0.0055715935,
0.0018940122,
-0.020202797,
-0.025728235,
-0.009105764,
0.00013722935,
0.018040095,
-0.017987346,
-0.010529983,
-0.013404793,
0.023750154,
0.014888354,
0.010358549,
0.012178383,
0.03344275,
0.031438295,
-0.022339124,
0.024132583,
-0.02070391,
0.013464135,
-0.007965071,
0.0014744942,
0.0005744676,
0.017618105,
0.010015681,
0.033785615,
0.031148177,
0.0094816,
0.024594136,
-0.010866256,
0.018251091,
-0.012171789,
-0.01956981,
0.006165018,
-0.0009066203,
-0.006046333,
0.017380735,
-0.013075112,
-0.010114585,
0.003728682,
0.006811191,
0.0039363806,
0.00023324868,
-0.02141602,
0.017433483,
-0.01905551,
-0.015415842,
-0.008611244,
0.011934419,
-0.0008917847,
-0.016905995,
0.016760936,
0.008248596,
0.023868838,
0.0033281206,
-0.012020136,
-0.013780628,
0.010193708,
-0.014519111,
0.020954467,
0.0068441588,
0.018251091,
0.0018066469,
-0.014123496,
0.027693128,
0.010325581,
-0.0033742758,
-0.0045462884,
0.0009494787,
0.0063067805,
0.002403368,
-0.007892542,
0.010173928,
-0.016853247,
-0.030963555,
0.02282705,
-0.007839792,
0.021442393,
-0.009092577,
-0.016141137,
0.008314532,
-0.018976387,
0.016154325,
0.0018874186,
0.046920072,
0.019635746,
0.02165339,
-0.017868662,
0.008650806,
-0.015837831,
-0.009277198,
-0.0008637619,
-0.0054034567,
-0.0030726185,
-0.019081885,
0.017934598,
-0.01726205,
-0.03608019,
0.026242536,
-0.0121586025,
0.018923638,
-0.008987079,
0.0040682526,
-0.001374766,
0.00924423,
-0.011400338,
-0.023591908,
-0.026097476,
-0.004186937,
-0.000621447,
-0.0067848163,
-0.04626071,
-0.0021429206,
0.004701238,
-0.026783211,
0.0051463065,
0.00924423,
0.021495143,
-0.009329947,
-0.008505747,
0.001168716,
-0.0150993485,
0.024910629,
-0.0047935485,
-0.0088947695,
-0.0033149335,
-0.024541387,
-0.03386474,
-0.0065968987,
-0.01726205,
0.03296801,
0.028484361,
-0.008268377,
-0.006491401,
-0.0020143455,
-0.0025863403,
-0.002301167,
0.006016662,
-0.012732245,
0.006010068,
0.0028434908,
0.013661943,
0.00079040806,
0.023499597,
0.015956517,
-0.016985118,
-0.0120135425,
-0.025952417,
-0.036845047,
-0.007707921,
0.059922654,
-0.0025335916,
-0.009587097,
0.014163057,
0.035737325,
0.00416386,
0.010292613,
-0.04301666,
0.010523389,
0.004816626,
0.001040965,
-0.0030940478,
-0.00042611154,
0.015244408,
0.02599198,
0.017103804,
-0.0042199055,
-0.01457186,
-0.0020637973,
-0.004688051,
0.005601265,
0.008235409,
0.031042678,
0.033574622,
0.014954289,
-0.013503697,
0.0034583441,
0.030884432,
0.01716974,
-0.0120399175,
-0.007048561,
0.022391872,
-0.0033891115,
0.017433483,
0.013464135,
-0.00811013,
0.00023695757,
-0.013530071,
0.00013671421,
0.008083756,
0.026862334,
0.0076815463,
0.013569633,
0.010734384,
0.027376635,
-0.0068573463,
-0.009501381,
0.00020800754,
-0.011611333,
-0.015587275,
0.027455758,
-0.022035819,
-0.005782589,
-0.017525794,
0.013134455,
-0.0038968187,
0.009653034,
0.0068441588,
0.0010681635,
0.0044935397,
-0.010411298,
-0.019556623,
0.0050177313,
-0.005238617,
-0.008426623,
0.006029849,
-0.01457186,
-0.030594314,
-0.03183391,
0.00021655862,
0.021943508,
-0.035763696,
0.009455225,
0.0039660516,
-0.0053441143,
-0.008492559,
0.0111893425,
-0.0134509485,
0.010200302,
0.009039829,
-0.004589147,
-0.008459591,
-0.017248863,
-0.0411177,
-0.0009890402,
0.0043979324,
0.0009535997,
-0.025833733,
-0.014031185,
0.0059177577,
0.011327808,
-0.004556179,
0.012712465,
-0.008749709,
-0.011677269,
-0.0037089011,
0.010820101,
0.0039660516,
-0.01414987,
-0.0040979236,
0.013259734,
-0.018950012,
-0.011624521,
-0.0043649646,
0.012639935,
-0.026717275,
-0.0069694375,
-0.0071474644,
-0.024000712,
-0.032888886,
0.022273188,
-0.02249737,
0.008710148,
0.005321037,
0.034313105,
0.03291526,
0.004292435,
-0.015020225,
0.011044283,
-0.0032852623,
-0.00433859,
0.015323531,
0.015745522,
-0.007622204,
-0.014268555,
-0.011967388,
0.01513891,
-0.0056737945,
-0.030488815,
-0.009527755,
-0.010813507,
0.041196827,
-0.026967833,
-0.031016303,
-0.028563485,
0.006936469,
-0.0031995454,
-0.0043682614,
0.0057100593,
-0.037108794,
-0.02255012,
0.002625902,
-0.005489174,
-0.010015681,
-0.0017489529,
-0.030778933,
0.0005996057,
0.026862334,
-0.003379221,
-0.027983246,
-0.001897309,
-0.009198075,
-0.009211262,
0.012930053,
-0.0036792299,
-0.016233448,
0.0006721353,
0.013193797,
0.02985583,
0.014202619,
0.01665544,
0.010292613,
0.00860465,
0.006563931,
0.015297157,
0.0036067003,
-0.01358282,
0.008973893,
-0.005169384,
0.015916955,
0.011077251,
-0.0052781785,
0.0042561702,
0.00867718,
0.021969883,
-0.00088848785,
-0.014031185,
-0.021627015,
-0.008650806,
-0.020888532,
-0.037056044,
-0.00079288066,
-0.0074837385,
-0.0029193172,
-0.033073507,
-0.017710416,
0.0079255095,
-0.011097033,
0.009751937,
-0.025649112,
0.011373963,
-0.0022649022,
0.0040056133,
-0.0073782406,
0.0041012205,
-0.017288424,
0.0016739507,
-0.0035176866,
0.00009874949,
0.00973875,
0.007239775,
0.019042322,
-0.007899135,
-0.01645763,
0.013174017,
0.0025187558,
-0.029934954,
-0.0021857792,
-0.00080235896,
-0.006310077,
0.0022418248,
-0.01924013,
-0.018330213,
-0.024541387,
-0.04291116,
0.014189431,
-0.01014096,
0.011288247,
-0.0077936375,
-0.010068431,
0.014532299,
0.004490243,
0.038137395,
-0.02231275,
0.03608019,
0.036950547,
-0.0017753274,
-0.032598767,
-0.010826695,
0.015323531,
-0.0066990997,
0.01490154,
0.02877448,
-0.011077251,
-0.011624521,
0.022800677,
0.020506103,
-0.02169295,
-0.029301967,
0.024752382,
-0.01414987,
-0.0114399,
-0.019556623,
-0.0091585135,
-0.00045454645,
0.019398376,
-0.009488193,
0.004806736,
0.003544061,
-0.026308471,
0.0110706575,
0.015086161,
-0.019029135,
0.006405684,
-0.019978615,
-0.03853301,
-0.020136861,
-0.03702967,
-0.010556357,
0.004836407,
-0.0052946624,
0.008301345,
0.009501381,
-0.0086574,
0.015455403,
-0.011795954,
0.0016698297,
-0.00040138554,
-0.010951973,
0.029170096,
0.0062869997,
-0.023750154,
0.020268733,
0.023051232,
0.019912679,
-0.003530874,
-0.0056078583,
-0.015758708,
-0.005597968,
0.009929964,
0.038638506,
0.015600462,
-0.014914728,
0.0074837385,
-0.008452998,
-0.004819923,
-0.028167868,
-0.0143344905,
0.028088745,
-0.023934776,
0.0012123985,
-0.01299599,
-0.003942974,
0.014136682,
-0.003642965,
0.003827586,
-0.0061023785,
0.040484715,
-0.018198341,
0.007951884,
0.008255189,
0.006408981,
-0.016088389,
0.014360866,
-0.021574266,
-0.019345628,
0.016497193,
-0.0035044996,
-0.0063331546,
-0.037319787,
-0.0040814397,
0.029987702,
0.025068875,
-0.010167334,
0.023947962,
0.023103982,
0.0024989753,
-0.015771896,
-0.017881848,
0.062138107,
-0.015521339,
-0.0013401496,
0.0051100417,
0.0017621402,
0.01641807,
-0.01660269,
-0.012606967,
-0.005133119,
-0.013596008,
-0.02877448,
-0.018145593,
0.034919716,
-0.018884076,
-0.0054397215,
-0.0011464625,
-0.009567317,
-0.0064815106,
0.0036067003,
0.013312482,
-0.0014011405,
-0.010648667,
-0.0001984262,
0.006099082,
-0.0065342598,
-0.0004994653,
-0.001889067,
0.0049946536,
-0.02216769,
-0.026123852,
0.01830384,
-0.02022917,
0.034260355,
0.035157084,
0.013457541,
-0.026071101,
-0.006290296,
-0.041355073,
0.00988381,
0.016312571,
0.03201853,
0.0031418514,
0.015864206,
0.027534882,
0.0096002845,
-0.008934331,
0.004691348,
-0.015178472,
-0.010101398,
0.006540853,
-0.013338856,
0.0085123405,
0.017710416,
-0.0233941,
-0.00037068405,
0.024660071,
0.03051519,
-0.028800854,
0.010714604,
-0.015758708,
0.003062728,
-0.0060397396,
-0.011842109,
-0.01235641,
-0.023433661,
-0.00042528732,
-0.03193941,
-0.015916955,
0.027693128,
-0.013622382,
-0.018198341,
-0.02226,
-0.004170453,
0.005650717,
0.0075035193,
0.011031096,
-0.028932726,
0.026163412,
-0.0026901895,
-0.0045298045,
0.0024791944,
0.027218388,
0.011664082,
0.026994206,
-0.012468501,
0.0046188184,
0.01490154,
0.002235231,
-0.012626748,
0.0042330925,
0.00523532,
-0.01726205,
-0.016114764,
-0.008993673,
-0.0122179445,
-0.00087282807,
-0.0039957226,
-0.02806237,
-0.023895213,
0.040906705,
0.0049320143,
-0.007668359,
-0.01094538,
0.018053282,
-0.0073848343,
-0.012119041,
-0.013457541,
0.037530784,
-0.020783033,
0.011373963,
0.0030841574,
0.0096002845,
0.014888354,
0.0069826245,
0.0003758353,
-0.01768404,
0.014914728,
0.1917947,
-0.0036957138,
0.020677537,
-0.003057783,
-0.011136594,
0.0005035864,
0.038322017,
0.014110308,
0.014519111,
0.017657666,
0.0065012914,
-0.0068309717,
0.00033936446,
0.008301345,
-0.012686091,
-0.023011671,
-0.040906705,
-0.013661943,
-0.019015947,
-0.0031797646,
-0.0044671656,
-0.0016096631,
-0.01129484,
-0.0055089546,
0.01570596,
-0.0045034303,
-0.017130177,
0.012165195,
0.021666577,
-0.0019484094,
-0.0018363182,
-0.012270694,
-0.011558584,
0.02169295,
-0.012376191,
0.0054298313,
0.0027857968,
-0.008070569,
0.0038836317,
-0.013701505,
-0.010503608,
0.021851197,
-0.026572216,
-0.028457986,
0.006804597,
-0.006798004,
0.009204668,
-0.009303573,
0.0048001423,
-0.0019170898,
-0.045258485,
-0.037372537,
0.0033099882,
0.011980575,
-0.01513891,
0.0036495586,
0.039640736,
0.017525794,
0.002147866,
0.011973981,
0.0073584598,
0.013622382,
-0.011143187,
0.008499153,
-0.012409159,
0.023934776,
-0.0147169195,
-0.020387417,
0.0075035193,
-0.03961436,
0.00050688314,
-0.030488815,
-0.019582998,
0.017196113,
-0.01334545,
0.005133119,
0.016800499,
0.011024502,
0.014690545,
0.018699456,
0.008987079,
0.001897309,
-0.025147999,
-0.012719058,
-0.0043682614,
-0.038031895,
0.031913035,
0.011314621,
-0.029934954,
0.011261872,
0.003395705,
0.0041275946,
-0.0022698476,
-0.008294751,
0.02075666,
0.021772074,
0.0039166,
-0.002650628,
0.01513891,
-0.012033324,
-0.022523744,
0.06656901,
0.0027890936,
0.0038242892,
0.012066292,
0.005386973,
-0.012442127,
-0.0042792475,
0.0154817775,
-0.011176155,
-0.0006169139,
-0.010529983,
0.004872672,
-0.013714693,
0.020677537,
0.026084289,
0.0036990107,
-0.019899491,
0.011690456,
0.002678651,
-0.014743294,
-0.033785615,
-0.0016047179,
0.019596186,
-0.007457364,
-0.012428939,
-0.02546449,
-0.0040682526,
-0.021139087,
-0.042884786,
0.0068177846,
-0.010167334,
-0.0077277017,
-0.00024952664,
0.009784905,
-0.0062243603,
-0.0011340996,
-0.038348388,
-0.020743473,
0.008670587,
-0.0012659716,
-0.021732513,
0.014017998,
0.011242092,
-0.00768814,
0.004694645,
0.0106882285,
0.020057738,
-0.02683596,
-0.0064221686,
-0.033838365,
-0.0070353732,
-0.024791943,
-0.002024236,
0.035631824,
-0.035552703,
-0.021376457,
-0.02527987,
0.011373963,
0.0044869464,
-0.031675663,
0.009936558,
0.019411564,
-0.007820012,
0.00093381887,
0.0057067624,
-0.16605328,
-0.006497995,
0.00080689206,
-0.024633696,
0.017433483,
-0.009092577,
0.0037220884,
0.009211262,
0.0139125,
0.006692506,
0.026242536,
0.0051463065,
-0.053091682,
-0.008255189,
0.029644834,
-0.0073914276,
-0.007945291,
0.020690722,
0.03468235,
-0.0015832887,
0.041671563,
-0.027429385,
0.02291936,
-0.012811368,
-0.008690367,
0.0021214914,
-0.0189632,
-0.011703644,
-0.014413614,
-0.0032176778,
-0.0042363894,
0.022761114,
0.0140707465,
-0.020637974,
-0.009514567,
-0.02055885,
0.0009783257,
0.007371647,
-0.009732157,
0.011090439,
0.038216516,
0.03051519,
-0.012745433,
0.026981018,
-0.011604739,
0.033600997,
0.009956339,
-0.0130685195,
0.026242536,
0.0067650354,
0.014360866,
-0.003778134,
0.051430095,
0.0016203776,
0.0021659983,
-0.00809035,
0.012402565,
0.00614194,
0.017420296,
0.009567317,
-0.026163412,
-0.017736789,
0.008598057,
-0.00818266,
0.002070391,
-0.016998306,
-0.029038223,
0.014189431,
-0.020123674,
0.019319253,
-0.027192015,
-0.0047704712,
-0.007055154,
-0.016787311,
0.035051588,
0.0073980214,
-0.01764448,
0.017275237,
0.008940924,
-0.0043319967,
-0.0046122246,
0.0038407731,
-0.0030412988,
-0.021152275,
-0.016826872,
-0.0052946624,
0.013543258,
0.013978437,
-0.013352044,
-0.023895213,
0.005083667,
-0.019543435,
-0.019437939,
-0.011650895,
-0.030647062,
0.020163234,
0.015640024,
0.006165018,
0.0013945468,
-0.012046511,
0.042937536,
-0.008848614,
-0.013556446,
0.03750441,
0.020202797,
-0.006771629,
-0.038374763,
0.011604739,
0.043412276,
0.004605631,
-0.0124223465,
0.0037814307,
0.032625142,
-0.007991445,
-0.022721553,
0.008149692,
-0.014993851,
-0.007424396,
-0.009112358,
-0.00005182159,
0.03331088,
0.021468768,
-0.019859929,
0.013938875,
0.014123496,
0.0024956784,
-0.13514246,
-0.019622559,
0.008050788,
0.014782855,
0.022563307,
0.044309005,
-0.0008761249,
-0.007055154,
-0.014242181,
0.02117865,
-0.013385012,
-0.0074309893,
-0.02004455,
-0.015402654,
0.038269266,
0.021824822,
0.01707743,
-0.00964644,
-0.01711699,
0.014598235,
0.012033324,
-0.0100420555,
-0.008261783,
-0.013701505,
0.02055885,
0.008031007,
-0.012231132,
-0.0068837204,
0.0076617654,
0.0067023966,
0.004843001,
-0.0016146083,
-0.007589236,
-0.0055913744,
-0.022484183,
-0.0102464575,
-0.015231221,
0.012811368,
0.022813862,
-0.05061249,
0.012086072,
0.002025884,
0.010167334,
-0.014611422,
0.0040352843,
0.0011926178,
-0.0083936555,
0.010892631,
0.012732245,
-0.0056836847,
-0.018264277,
-0.011499242,
-0.019662121,
-0.022114942,
0.00015618595,
-0.033600997,
-0.022299562,
0.019174194,
-0.022629242,
0.0028797556,
0.0072265877,
-0.0045792568,
-0.0072991173,
0.019543435,
0.027376635,
-0.018593958,
0.0006387552,
-0.006629867,
0.0134509485,
-0.051904835,
-0.010543169,
-0.009132138,
-0.016629064,
0.0022286375,
-0.022101754,
0.011710237,
0.011400338,
-0.00014681066,
0.015020225,
-0.0010096453,
-0.011024502,
-0.006478214,
0.033416376,
-0.02018961,
0.016075201,
0.017947786,
0.0077738566,
0.008222221,
0.0020555553,
0.0063166707,
-0.0117761735,
0.00785298,
-0.013193797,
-0.022391872,
0.0057100593,
0.008288158,
-0.0019929162,
-0.013239953,
0.008004633,
0.03621206,
-0.025385369,
-0.013312482,
-0.05259057,
0.007371647,
-0.013661943,
-0.017393922,
0.0072463686,
-0.024871066,
0.022774301,
-0.008261783,
0.0027083221,
0.011723424,
-0.030778933,
0.0059342417,
-0.009686002,
0.005073777,
-0.029433839,
0.0173148,
0.015771896,
0.015494965,
0.018356588,
0.019503875,
0.0033083397,
0.016787311,
-0.0013970194,
0.004259467,
-0.01740711,
0.016998306,
0.01806647,
0.024488637,
-0.028510734,
-0.0013920743,
0.0025583175,
-0.0122179445,
0.010477234,
0.00046072793,
0.022945736,
-0.023354538,
0.0077936375,
0.0066859126,
0.02641397,
0.04871353,
-0.012323442,
-0.027561257,
0.0031748193,
0.010595919,
0.014360866,
0.010464046,
-0.0008101888,
0.018501647,
0.02372378,
0.020242358,
0.038216516,
0.0014835604,
-0.015494965,
-0.0022368794,
-0.012587186,
0.00088436686,
0.0073518665,
-0.014967477,
0.0013508642,
-0.027323887,
0.005614452,
0.031622916,
0.0010986589,
0.016523566,
0.007180433,
-0.006016662,
-0.025846919,
-0.022035819,
0.029671209,
-0.024396328,
-0.014743294,
0.0045331013,
-0.008215628,
0.0064683235,
-0.011611333,
-0.023183106,
-0.011604739,
0.025609551,
0.008103536,
-0.0076156105,
-0.0052616945,
-0.018699456,
-0.02046654,
0.025635924,
0.031069053,
0.002609418,
0.009784905,
-0.006026552,
-0.0029588789,
0.0036001068,
0.01693237,
0.029117346,
-0.003074267,
0.0052979593,
0.008136505,
0.018673081,
-0.008063975,
-0.014690545,
0.009138732,
0.05918417,
-0.0048462977,
0.009969526,
-0.0178291,
-0.00498806,
-0.008611244,
-0.006310077,
-0.0103058,
-0.031913035,
0.0018824734,
-0.0053078495,
0.007826606,
0.008123318,
0.0027956872,
0.00043971083,
-0.005073777,
-0.00077062723,
-0.01169705,
-0.0019039026,
-0.004826517,
0.021679763,
-0.00058765477,
0.021679763,
-0.0012915218,
-0.017433483,
-0.0013574578,
-0.0026605185,
0.029301967,
-0.0111893425,
-0.0026324957,
-0.018686268,
-0.008116724,
-0.02004455,
-0.02758763,
-0.025319431,
-0.014136682,
-0.018607145,
0.0240139,
-0.0069628437,
-0.002790742,
0.056915972,
-0.009066203,
-0.016998306,
0.012138821,
-0.023829278,
0.0133058885,
0.017156553,
0.0150993485,
0.003329769,
-0.016708188,
0.020084111,
-0.015745522,
0.011169562,
-0.0600809,
-0.007437583,
0.008518934,
-0.0052748816,
0.02476557,
-0.014650984,
0.0034022985,
0.034075737,
0.006771629,
0.018171968,
-0.0031022897,
-0.025293058,
0.0027017284,
0.04037922,
-0.0101871155,
0.0091717,
-0.050269622,
-0.026361221,
0.001963245,
-0.0034385636,
-0.026519468,
-0.0015330125,
-0.0044968366,
-0.0148356045,
-0.028642608,
0.031860285,
0.023974337,
-0.02004455,
0.0016401585,
-0.014083934,
-0.03433948,
-0.029697584,
-0.010879443,
-0.03291526,
-0.006610086,
0.0034352667
] |
This paper highlights methods for using geospatial analysis to assess, enhance, and improve recruitment efforts to ensure representativeness in study populations. We apply these methods to the Measurement to Understand Reclassification of Disease of Cabarrus/Kannapolis (MURDOCK) study, a longitudinal population health study focused on the city of Kannapolis and Cabarrus County, NC. Although efforts have been made to recruit a participant registry that is representative of the 18 ZIP code catchment region inclusive of Cabarrus County and Kannapolis, bias in such recruitment is inevitable. Participants in the MURDOCK study are geospatial
|
[
-0.016423294,
0.011733867,
0.015970144,
-0.046853077,
-0.024277914,
0.030512175,
-0.012708829,
0.020227017,
-0.025417658,
-0.013354226,
-0.023824763,
0.012784354,
0.011816259,
0.020597778,
-0.008939436,
0.013402287,
0.036828827,
-0.02952348,
-0.012612706,
-0.0077173007,
-0.012001638,
0.012283142,
0.0018023056,
-0.008252843,
-0.0262553,
0.032297317,
0.01346408,
-0.02869957,
-0.015242355,
0.019471766,
0.009571101,
-0.010779504,
-0.013436617,
-0.028507324,
-0.03515354,
-0.0018332022,
0.013484678,
-0.03584013,
0.0031669084,
-0.021023465,
0.012001638,
-0.027079212,
-0.0061244057,
-0.057948414,
0.029496018,
0.02306951,
0.0030381721,
-0.020776292,
-0.03485144,
0.01368379,
0.0045624077,
0.030539637,
-0.009770213,
0.005757079,
0.02120198,
-0.002210828,
0.008980631,
0.003920444,
-0.018592928,
-0.034164846,
0.009385721,
0.006831596,
-0.011836857,
0.005547668,
-0.032956444,
-0.022204405,
-0.0020958239,
0.009337659,
0.0070787696,
0.013999623,
0.031638186,
0.035428178,
-0.006189632,
-0.01646449,
0.028534789,
-0.011630879,
0.00084407977,
-0.001276204,
0.03811962,
0.014844132,
-0.00017829951,
-0.024126863,
0.0002285066,
0.022657555,
0.025417658,
-0.0019173098,
0.020419264,
0.018716514,
0.001900145,
0.008033133,
-0.014844132,
0.03323108,
0.012365532,
-0.018661587,
-0.018469341,
0.0056643886,
-0.009234671,
0.039492805,
0.014706813,
-0.03446695,
-0.009426916,
0.012035968,
-0.019773867,
-0.018634122,
-0.023824763,
-0.0007840029,
-0.00472719,
-0.012770622,
0.027614754,
-0.008980631,
0.00222456,
0.023824763,
0.010944285,
-0.009928129,
0.008815849,
-0.029688263,
-0.0143772485,
0.008094926,
0.0005818872,
0.0022623225,
0.0027532363,
0.013120784,
0.017302133,
-0.005657523,
0.04792416,
0.03100652,
-0.035428178,
0.0010221647,
0.0025043464,
-0.02120198,
-0.033121224,
-0.00454181,
0.024621211,
0.02447016,
-0.008403894,
0.0035805802,
-0.0072092223,
0.008458821,
-0.036361944,
-0.021957232,
-0.0064059086,
0.020721365,
0.0040268656,
-0.017823944,
-0.009749615,
0.007696703,
0.042815913,
0.00663935,
0.01802992,
-0.008005669,
0.005369154,
-0.040591355,
0.015256087,
0.0057879756,
-0.0107177105,
0.003105115,
0.011095336,
0.00901496,
-0.0067011435,
-0.031336084,
-0.008170452,
-0.003697301,
-0.012907941,
0.0022966522,
-0.0028819724,
0.022959655,
0.012756891,
-0.0024236718,
0.01757677,
-0.0041264216,
-0.002830478,
0.053361975,
-0.027875658,
0.022410382,
-0.003045038,
0.00034308175,
-0.010243962,
0.02765595,
-0.024868384,
0.01198104,
-0.0033042268,
0.029550945,
0.028727034,
0.01705496,
-0.024264181,
0.005369154,
0.023330417,
0.011802526,
-0.0048988382,
-0.014487104,
0.012125225,
-0.002585021,
-0.00067758106,
-0.003958206,
-0.64287037,
-0.020419264,
0.017260937,
0.006464269,
-0.021641398,
0.010559794,
0.028507324,
-0.012090895,
0.00014901205,
0.04976423,
0.008108659,
0.013107052,
-0.013058991,
-0.014967718,
-0.026900697,
-0.022382919,
-0.009804542,
-0.006852194,
0.027449971,
0.007888949,
-0.027408777,
0.0071817585,
0.0028390603,
0.01750811,
-0.0046070362,
0.035620425,
0.019485498,
-0.0028974207,
-0.00663935,
0.018112313,
-0.032983907,
0.017974993,
-0.0016847266,
0.013326762,
0.04064628,
-0.003906712,
-0.011472962,
0.014665618,
0.01368379,
0.026186641,
-0.00782029,
-0.034219775,
0.02817776,
0.004177916,
-0.013244371,
0.006587856,
-0.0038380525,
0.006587856,
0.010491135,
0.0008882792,
-0.011260118,
0.02106466,
0.0006934585,
-0.0032235521,
0.010827565,
-0.020941073,
0.012187018,
-0.011349375,
0.013745584,
-0.008177318,
-0.011321912,
-0.0011225789,
-0.00086339016,
-0.020721365,
-0.023275489,
0.03092413,
-0.0022159775,
0.0062651574,
-0.024593746,
0.0021559007,
-0.00044371045,
0.04243142,
-0.0074152,
0.009941861,
0.036966145,
0.023083244,
0.016917642,
-0.011932979,
-0.016382098,
-0.016491953,
-0.000010560384,
0.00037204736,
-0.030539637,
0.005722749,
-0.004243142,
-0.0076486412,
-0.02952348,
0.015901484,
0.007868351,
0.0024494191,
0.02826015,
-0.019046078,
-0.011507291,
-0.011521024,
0.02150408,
0.00074495294,
-0.011033542,
0.01934818,
0.005458411,
-0.040728673,
-0.024209255,
-0.017769016,
0.0108756265,
-0.012447923,
0.02418179,
0.012193885,
0.0039547733,
0.012736293,
0.046880543,
-0.025184216,
0.0066839787,
-0.007113099,
0.006852194,
-0.017329596,
-0.0014675916,
-0.032764196,
0.023000851,
0.000037816233,
0.00088227144,
-0.018730246,
0.012317471,
0.010168436,
0.040893454,
-0.032736734,
-0.006306353,
0.003958206,
-0.0014504269,
0.010971749,
-0.0015122201,
-0.029990364,
0.0062617245,
-0.006230828,
0.017920066,
-0.0032458664,
0.025554975,
-0.007023842,
0.0120497,
-0.0027961484,
-0.008520614,
-0.035126075,
-0.021737522,
-0.027024284,
0.01572297,
-0.02558244,
-0.0047958493,
-0.010923688,
-0.010951152,
-0.008245977,
-0.00032527323,
-0.00775163,
-0.0053142267,
-0.013807377,
0.0007659799,
-0.0010384712,
-0.018277094,
0.0035599826,
0.010827565,
0.003886114,
-0.013745584,
-0.008012535,
0.013759315,
0.005860068,
-0.044326417,
-0.017466916,
0.00704444,
-0.021147052,
0.0132787,
0.031775504,
0.011891783,
-0.015105037,
0.019691475,
-0.019458033,
-0.010662783,
0.022877265,
0.005568266,
0.008046865,
-0.016807787,
0.006000819,
-0.013992757,
-0.011809393,
0.010086045,
-0.007676105,
-0.017109888,
-0.017865138,
0.004445687,
-0.007126831,
0.030567102,
-0.0076280436,
-0.013944696,
0.02499197,
-0.01123952,
0.0072984793,
-0.015022646,
0.013374823,
0.016382098,
0.023096975,
-0.0034432618,
0.0013963577,
0.008129256,
0.018716514,
0.013649461,
0.0006290905,
0.029331235,
0.012619572,
0.019046078,
-0.02692816,
0.0084725525,
-0.030292464,
0.018743977,
-0.0007187766,
0.0098869335,
0.0012221348,
-0.017466916,
0.009680956,
-0.02817776,
0.035538033,
-0.0061656013,
-0.0022417249,
-0.014596959,
0.0077584963,
0.018483073,
0.013711254,
0.040454034,
0.012688231,
0.0008616737,
-0.015393406,
0.019224592,
0.032434635,
0.012152689,
-0.0070787696,
0.005001827,
0.022890996,
0.005949325,
0.023481466,
0.02484092,
-0.00036239214,
0.0076143118,
-0.020584045,
0.026639793,
0.01572297,
0.015462065,
0.03405499,
0.010017386,
-0.013271835,
0.01712362,
-0.025115557,
0.019320715,
0.012187018,
-0.003886114,
0.021009734,
-0.0012590392,
0.0034604266,
-0.0069929454,
0.014185003,
-0.0004488599,
-0.031638186,
-0.0033093763,
0.0044044913,
0.04322787,
0.025252875,
0.017233474,
0.028424934,
0.023302952,
-0.028864352,
-0.006399043,
0.00048748075,
-0.0057845423,
-0.018496804,
-0.01445964,
-0.011170861,
0.0069002556,
-0.0045692734,
-0.013876036,
-0.008211647,
-0.011356241,
-0.0012427326,
0.012736293,
-0.012180152,
0.024030741,
-0.0014272543,
-0.020790024,
-0.018716514,
0.035730276,
0.051027562,
-0.016478222,
-0.017466916,
-0.030567102,
-0.0076486412,
-0.035620425,
-0.0026090518,
0.0043976256,
0.013663192,
0.011232655,
-0.014445908,
-0.0055270703,
0.009509307,
0.0072504175,
-0.022959655,
0.006399043,
-0.0011938128,
-0.0050430223,
0.010237096,
-0.0032716137,
-0.0057124505,
0.01282555,
0.015832825,
-0.0011157129,
-0.00673204,
-0.01408888,
-0.019993575,
0.018304558,
-0.0020649272,
0.00793701,
0.044463735,
-0.019787598,
0.018386949,
-0.012035968,
0.007422066,
0.013525874,
0.009021827,
0.0056025954,
-0.032159995,
0.0016323739,
0.008554944,
0.07558011,
-0.0038277537,
0.0038277537,
0.007978206,
0.009516173,
-0.0031119809,
-0.00015802357,
-0.033588108,
0.0143772485,
-0.0010479119,
-0.034659192,
-0.00194649,
0.022245599,
0.010594124,
0.019664012,
0.012118359,
-0.003968505,
-0.012255678,
-0.014953987,
0.023522662,
-0.008699128,
-0.0076349094,
0.010649051,
0.013848572,
0.026969356,
0.0021026898,
0.026269032,
0.03136355,
-0.017398257,
-0.020213285,
-0.022039622,
0.013367957,
-0.0019705207,
0.030814275,
-0.005963057,
0.01461069,
0.027889391,
-0.012914807,
0.011369973,
-0.00509795,
0.00722982,
0.007868351,
0.009179743,
-0.014734277,
0.04144273,
0.0015491245,
0.017920066,
0.011260118,
0.020941073,
-0.011994773,
0.026832039,
-0.03018261,
0.0062788893,
-0.026296496,
0.00565409,
-0.012846148,
0.01346408,
-0.016423294,
-0.0056060283,
0.013223773,
-0.032956444,
-0.0014761741,
0.006272023,
-0.0024854653,
-0.013999623,
-0.020089699,
-0.0075387866,
0.002598753,
-0.020776292,
-0.0031257127,
0.009948727,
-0.018922491,
-0.014596959,
0.012290007,
0.012090895,
0.015146232,
0.03254449,
-0.014748009,
-0.001686443,
-0.00546871,
-0.0065157637,
0.0011491843,
-0.005722749,
-0.017700357,
-0.01624478,
0.019334447,
-0.022259332,
-0.0050636204,
-0.005200939,
0.0048988382,
-0.0035067715,
0.01346408,
-0.0015105037,
0.011768197,
0.0010590691,
0.006285755,
0.025966931,
0.0037178989,
-0.010443073,
-0.014665618,
0.007483859,
-0.00945438,
-0.012351801,
-0.007703569,
0.0093033295,
-0.013601399,
-0.0103812795,
0.005273031,
-0.010395012,
-0.0033849014,
0.033176154,
-0.0054103495,
0.008891374,
-0.020227017,
-0.008843312,
0.0024768827,
-0.0020975403,
0.011514158,
0.008925703,
-0.0067183087,
-0.00045830055,
0.008362697,
-0.000730792,
0.020158358,
-0.02121571,
0.014899059,
-0.030869203,
-0.017329596,
-0.022932192,
-0.016862715,
-0.028315078,
0.04182722,
-0.011479828,
-0.028287614,
-0.0045692734,
-0.01735706,
-0.006924286,
0.02765595,
-0.019856257,
0.009124815,
-0.017151082,
0.0019276086,
0.007765362,
-0.020144626,
0.03762527,
-0.030210074,
-0.02447016,
0.003999402,
-0.001943057,
0.013965293,
-0.011555353,
0.0049468996,
0.0044662845,
-0.017700357,
-0.008479418,
-0.012495985,
-0.0064951656,
0.0030742183,
0.040179398,
0.010786369,
0.04894032,
0.015558188,
0.009289598,
-0.000859099,
0.0065260627,
-0.009063022,
0.00026476727,
-0.0033248246,
-0.0052524335,
0.0012410161,
0.006934585,
0.0007960183,
-0.001247882,
0.009818274,
-0.0038723822,
0.032297317,
0.0012281425,
0.0033780355,
-0.013642594,
-0.022575164,
-0.024483891,
0.00069603324,
-0.005400051,
0.019815061,
-0.035757743,
0.0030501876,
0.03908085,
0.014349785,
0.009317061,
-0.0048336117,
0.01912847,
-0.0049709305,
0.010147839,
-0.0029145854,
0.0013671775,
-0.007909547,
0.0008616737,
-0.024222987,
0.007332809,
-0.003045038,
-0.0003658251,
0.0065432275,
0.013244371,
0.0022417249,
-0.0064539704,
0.022012157,
-0.010909956,
-0.009241536,
0.004891972,
-0.029798118,
-0.016231049,
-0.01123952,
-0.008074329,
-0.006103808,
-0.00066642393,
0.010662783,
-0.017631698,
0.020968538,
-0.009248402,
-0.0057021515,
0.004280905,
-0.00034908942,
0.010511733,
0.0052421344,
0.031391013,
0.011363108,
-0.012228214,
-0.013340494,
0.019567888,
0.0116377445,
-0.022973388,
0.018428145,
0.0072778813,
-0.012859879,
-0.021929767,
0.03240717,
-0.0013234072,
-0.014665618,
-0.020570314,
0.018716514,
0.023673713,
-0.0053966176,
-0.019636547,
0.002542109,
-0.04558975,
-0.0006767228,
-0.023893422,
-0.04212932,
-0.0027549528,
-0.011836857,
-0.016176121,
0.019252056,
-0.014899059,
0.014033953,
0.01564058,
-0.016601808,
-0.002509496,
-0.01208403,
-0.0040199994,
0.0039444743,
0.0012006788,
-0.0005823163,
-0.0150501095,
-0.008774653,
0.011706403,
0.005104816,
0.015022646,
0.01238613,
-0.010882492,
0.036307015,
-0.0139721595,
-0.015928948,
-0.014473372,
-0.010628453,
0.0074289315,
0.010697112,
-0.023316683,
-0.03567535,
-0.0068144314,
0.015530724,
0.016340904,
0.0019138769,
-0.008280306,
0.0018761143,
0.0041023907,
-0.016670467,
-0.019705208,
-0.00034522734,
0.013134516,
-0.014528299,
-0.026186641,
0.007511323,
0.002816746,
0.012207616,
0.0011740733,
0.0043735947,
0.0006303778,
0.015475797,
-0.02269875,
0.027504899,
0.0027789834,
-0.0110541405,
-0.027628485,
0.015970144,
0.0017714088,
-0.035181005,
0.016011339,
-0.021174515,
-0.031253695,
-0.033121224,
-0.014198734,
0.015626848,
-0.017109888,
-0.0060694786,
0.022424113,
0.0020717932,
0.011919247,
-0.009166011,
-0.012763756,
0.032819126,
-0.013889768,
-0.0011543338,
0.024346573,
-0.028370006,
0.018043654,
-0.022520237,
-0.00043341157,
0.022973388,
-0.03292898,
-0.029825581,
-0.010017386,
-0.00009279728,
-0.03685629,
0.02142169,
-0.020364337,
-0.005849769,
-0.002713757,
0.01557192,
0.026832039,
-0.0014109478,
0.013642594,
-0.001429829,
-0.018084848,
0.02566483,
0.012605839,
-0.010456805,
-0.020721365,
-0.0077173007,
-0.03762527,
0.013670058,
-0.027779536,
0.02217694,
0.014281126,
-0.034357093,
-0.042156786,
0.0011414601,
-0.03463173,
-0.044683445,
0.008774653,
0.005551101,
0.011685805,
0.007319077,
0.016890178,
0.0069689145,
0.0065088975,
0.019375643,
-0.005080785,
-0.024236718,
0.017769016,
-0.016670467,
0.031693112,
0.005757079,
-0.026680987,
0.0039032788,
0.02320683,
0.020062236,
0.0007621178,
0.040948384,
-0.0033162422,
-0.017384524,
-0.008431357,
0.0011757897,
0.003999402,
-0.01115713,
0.009234671,
-0.034302164,
-0.022863533,
-0.004071494,
0.009523039,
0.015008914,
-0.011246387,
0.027243994,
0.0034844573,
0.013779913,
-0.022218136,
-0.013594533,
0.017260937,
-0.014912791,
0.0073671383,
0.033752892,
-0.014198734,
0.013107052,
0.024085667,
-0.027051749,
-0.01368379,
-0.017823944,
-0.022369187,
0.010786369,
0.0010951152,
-0.0016606958,
-0.001625508,
-0.021600204,
-0.01557192,
-0.02773834,
-0.009928129,
-0.023220561,
-0.013800511,
-0.0039341757,
0.014294857,
-0.005269598,
-0.03270927,
-0.00081833254,
0.0007732749,
-0.0447933,
0.005492741,
0.008774653,
-0.027985513,
-0.014693081,
0.01371812,
0.011033542,
-0.023110706,
0.024305377,
0.0069860797,
-0.004905704,
-0.021229442,
0.028781962,
0.1871926,
0.0023000853,
-0.003008992,
0.019993575,
-0.017219743,
0.02438777,
0.016643004,
0.008705994,
-0.010504867,
0.010971749,
0.018743977,
-0.016574346,
-0.0012607556,
0.0011311612,
0.0071611605,
0.004909137,
-0.003065636,
-0.02603559,
0.007875217,
-0.010539196,
0.025980663,
-0.012564644,
-0.011418034,
-0.016368367,
0.016780322,
0.0048576426,
0.0011775063,
-0.00975648,
0.0022331423,
0.035757743,
-0.00979081,
0.010003654,
0.019952381,
0.00028214665,
-0.0152972825,
0.01868905,
-0.008259709,
-0.013333628,
0.023893422,
0.022424113,
0.0021953797,
-0.020048503,
-0.005094517,
-0.00058660755,
0.0010667932,
0.012619572,
-0.0020563449,
0.019554157,
-0.0038380525,
-0.009811408,
-0.040179398,
0.0038311866,
0.010971749,
0.014802936,
-0.02061151,
-0.011177727,
-0.000531251,
-0.006385311,
0.002324116,
0.00042010884,
-0.020199554,
0.0004364154,
-0.009426916,
0.0084725525,
-0.023165634,
0.00407836,
-0.014665618,
-0.001229859,
-0.012832415,
-0.042294104,
0.0049709305,
-0.02676338,
0.021833643,
0.014253662,
0.008733458,
-0.0234952,
0.016629273,
0.001900145,
0.026653524,
0.022410382,
0.019252056,
-0.004363296,
-0.011328777,
-0.017439451,
-0.02202589,
-0.03943788,
0.026076786,
0.006090076,
-0.01675286,
-0.0028493593,
-0.021023465,
-0.008211647,
-0.023701176,
-0.03372543,
0.0026107682,
0.01742572,
-0.0072641494,
0.007985072,
-0.017563038,
-0.009921263,
-0.039355487,
0.064704485,
0.008987497,
-0.00398567,
-0.0037625274,
0.009385721,
-0.007676105,
0.01520116,
0.015558188,
0.0068144314,
0.006852194,
-0.03040232,
0.013690656,
-0.003026157,
0.02632396,
0.01594268,
0.050588142,
-0.009275866,
0.02335788,
0.0038414856,
-0.008362697,
-0.014212467,
-0.009227804,
0.034082457,
-0.0074357977,
-0.014102612,
-0.013539606,
-0.008321502,
-0.017974993,
-0.018400682,
-0.006296054,
-0.03284659,
0.016450759,
-0.020707631,
0.0016486804,
-0.012592108,
-0.00021316553,
-0.035922524,
-0.028974207,
0.012619572,
0.018441876,
-0.009104217,
0.012365532,
-0.0035977452,
-0.01862039,
-0.00815672,
-0.008932569,
0.036746435,
-0.009035558,
-0.0030210074,
-0.0077584963,
-0.023975814,
-0.009131681,
-0.018785173,
0.023618786,
-0.025829613,
-0.016258512,
-0.022932192,
-0.0026365155,
0.0039135776,
-0.013834841,
-0.011280716,
0.01594268,
-0.0035908793,
-0.015091305,
0.008053731,
-0.17609726,
0.011102202,
0.014720545,
-0.026584866,
0.011692672,
0.004823313,
0.025568709,
0.024236718,
-0.013203176,
-0.01579163,
0.02261636,
0.008458821,
-0.0336705,
-0.01248912,
0.011431767,
-0.0035977452,
-0.024621211,
0.015434601,
0.0069757807,
0.018359486,
0.03314869,
-0.017370792,
0.008822715,
-0.0059802216,
-0.003896413,
-0.015530724,
-0.015846556,
0.0043255333,
-0.010374414,
-0.03092413,
0.00083378085,
0.004548676,
0.0058154394,
0.0008217655,
0.001244449,
0.014679349,
0.000948356,
-0.0050224247,
0.0005351131,
-0.0024374037,
-0.0020082833,
0.0117476,
-0.01238613,
0.008259709,
-0.0059973863,
0.030539637,
0.026859501,
0.0015843124,
0.016794054,
-0.015091305,
-0.008108659,
-0.00500526,
0.025335267,
0.0086304685,
0.029193917,
0.024964506,
-0.014720545,
0.005018992,
-0.016519418,
0.002221127,
-0.018208435,
-0.016766591,
0.0065947217,
-0.0037487955,
0.005348556,
-0.037542883,
-0.016121194,
0.0021267205,
-0.014542031,
-0.0035462508,
-0.019334447,
0.0136357285,
-0.00797134,
-0.010491135,
0.02247904,
0.008259709,
-0.012736293,
0.029798118,
0.00019997009,
-0.01824963,
-0.010758906,
0.023742372,
-0.020446727,
-0.00075310626,
-0.0021953797,
-0.0071680266,
0.0039444743,
0.006577557,
0.036389407,
-0.004531511,
0.0053588552,
-0.026969356,
0.015008914,
-0.032132532,
0.031418476,
0.018208435,
-0.012619572,
-0.0082940385,
0.017439451,
-0.047512207,
0.015777897,
-0.01949923,
-0.029578408,
0.039904762,
0.025568709,
-0.015448333,
0.007593714,
0.0069071213,
0.025088092,
0.0046928604,
-0.003796857,
-0.018510535,
0.01535221,
-0.016382098,
-0.0047683856,
0.0441891,
0.012207616,
-0.0038689491,
0.015462065,
0.0064333724,
0.053554222,
-0.0067148753,
0.0023086676,
-0.013189443,
-0.011115934,
-0.008582408,
-0.11007452,
0.010525464,
0.0074632615,
-0.007099367,
-0.020446727,
0.019828795,
-0.008980631,
-0.00057416304,
-0.014418445,
0.03501622,
-0.011074739,
0.0013491544,
-0.0058669336,
0.010360682,
0.026282765,
-0.023975814,
0.0012753457,
-0.008788385,
0.009543637,
0.037268244,
-0.012729427,
-0.03581267,
-0.016395831,
-0.014130075,
-0.0027532363,
0.03130862,
-0.026392618,
0.025939468,
0.01943057,
0.0061621685,
-0.0091454135,
-0.016890178,
0.019677743,
-0.0237973,
-0.018345755,
-0.0039410414,
-0.0413878,
-0.012090895,
0.013361092,
-0.020968538,
-0.0038655163,
0.006409342,
0.024621211,
-0.00060591794,
0.009063022,
-0.010408743,
-0.030896666,
0.012921672,
0.019403106,
-0.022369187,
0.00040959538,
-0.0012109777,
-0.0026759945,
-0.016890178,
-0.0029403327,
-0.022959655,
0.00017218455,
-0.0021044062,
-0.01346408,
0.009275866,
-0.007607446,
0.01794753,
-0.02121571,
0.0056643886,
0.030374857,
0.0007882941,
-0.030265002,
-0.008005669,
0.005300495,
-0.011163996,
-0.03254449,
0.016574346,
0.010649051,
0.004991528,
-0.016052535,
-0.0041435864,
-0.027038015,
0.0008410759,
0.016519418,
-0.016821519,
0.0014015071,
-0.010587257,
0.015365942,
-0.016656736,
0.032462098,
0.017151082,
-0.013676925,
-0.011019811,
-0.0021970964,
-0.031116376,
-0.012276275,
0.039739978,
0.004435388,
0.0016358069,
-0.0022588896,
0.02891928,
-0.00037912783,
0.0068178643,
0.018867563,
-0.002028881,
-0.027189067,
-0.027312653,
-0.06223275,
0.01520116,
0.026680987,
-0.0040028347,
-0.024662405,
-0.021229442,
0.021943498,
0.0013954995,
0.0016246497,
-0.0010384712,
-0.012351801,
0.027161602,
-0.012564644,
0.003390051,
-0.036554188,
-0.0024013575,
0.01034695,
-0.0015156531,
0.03537325,
0.03114384,
-0.005262732,
0.018949956,
0.0020906744,
0.0007501024,
-0.008616737,
-0.010237096,
-0.026296496,
0.020460458,
0.000004968409,
-0.013072723,
-0.004991528,
-0.011369973,
0.005348556,
0.023989545,
-0.003154893,
-0.008362697,
0.027559826,
0.022849802,
0.013175712,
0.037405565,
-0.021270638,
-0.022643823,
0.012969734,
-0.01727467,
-0.0101341065,
0.005914995,
-0.015434601,
0.014294857,
-0.021353029,
-0.008747189,
0.016354635,
0.003525653,
0.006220529,
-0.013615131,
0.0031205632,
-0.024621211,
-0.0140614165,
0.0050224247,
0.004346131,
-0.043337725,
0.028342541,
0.017659161,
0.009516173,
0.0063303835,
0.01550326,
-0.010065448,
-0.017247206,
0.029496018,
0.012317471,
-0.025431389,
-0.024937043,
-0.022259332,
0.013773047,
-0.013223773,
-0.008218513,
-0.020117164,
-0.0020477623,
0.0010882493,
0.015036378,
0.019842526,
0.0011019811,
-0.00213187,
-0.017109888,
0.026227837,
0.016862715,
-0.0034810244,
-0.0016907343,
0.0140614165,
0.010037984,
0.01579163,
-0.010848163,
0.0103812795,
0.013807377,
-0.00012916523,
-0.035620425,
0.011390571,
0.0022091116,
-0.013120784,
0.064265065,
0.046386193,
0.0019516394,
0.010003654,
0.012598974,
-0.027491167,
-0.012585242,
0.0045933044,
-0.006399043,
-0.018647855,
-0.022437846,
0.019897453,
0.0113013135,
0.0036423737,
-0.010491135,
-0.009694687,
0.010367548,
0.009447514,
0.0055030393,
-0.0012907941,
-0.02692816,
0.027408777,
0.00023215411,
0.002185081,
-0.0006106383,
0.010237096,
0.0024545684,
0.0087197255,
-0.00083120615,
-0.020487923,
0.018895028,
-0.0017036078,
0.009838872,
0.0038208878,
-0.013587668,
-0.00034351085,
-0.026076786,
-0.000730792,
0.03463173,
-0.0022794874,
0.007099367,
0.07728286,
0.02817776,
-0.024785992,
0.002727489,
-0.020652706,
0.032159995,
0.008129256,
0.0034140816,
-0.011891783,
-0.04166244,
0.0039273095,
-0.009729017,
0.033258546,
-0.040289253,
-0.008355832,
0.008108659,
0.0012341501,
0.042733524,
0.00979081,
-0.022630092,
0.017411988,
-0.010889359,
0.014349785,
0.01712362,
-0.022218136,
-0.013814243,
-0.0034535606,
-0.014528299,
-0.0058772326,
-0.013244371,
0.0102233635,
-0.001433262,
-0.013189443,
-0.024868384,
-0.00018452176,
-0.018606659,
0.0006119256,
-0.02654367,
0.025788417,
0.004984662,
0.0053416905,
-0.0148304,
-0.033478253,
-0.0034999058,
-0.0041229883,
-0.021449152,
0.0005488449,
-0.029056598,
0.0008136122
] |
The direct detection of haplotypes from short-read DNA sequencing data requires changes to existing small-variant detection methods. Here, we develop a Bayesian statistical framework which is capable of modeling multiallelic loci in sets of individuals with non-uniform copy number. We then describe our implementation of this framework in a haplotype-based variant detector, FreeBayes.
|
[
-0.036969427,
0.013389654,
-0.009289409,
-0.03446895,
-0.023405008,
0.032882623,
-0.006499897,
0.00015985077,
-0.020205472,
0.012683874,
-0.0049471813,
0.011406749,
0.005168998,
0.015701924,
0.015701924,
-0.0018888017,
0.028258085,
-0.007340112,
0.011924321,
-0.001987947,
-0.023015149,
0.028365633,
0.0124082845,
-0.026900299,
-0.0009830507,
0.030140165,
0.02051467,
-0.015150744,
-0.021939674,
0.0006377226,
0.02435949,
0.015580933,
-0.01701938,
-0.016468199,
-0.010734578,
0.0041069672,
0.010042241,
0.012004981,
0.015782585,
-0.013698854,
0.013067012,
-0.0020568445,
-0.007286338,
-0.02133472,
0.02266562,
-0.00005148938,
0.03788358,
-0.0005415181,
-0.037749145,
-0.011453801,
0.0019761838,
0.013235055,
-0.008220656,
0.0032717942,
-0.013981165,
-0.0024114149,
0.008187047,
-0.01658919,
-0.013665245,
-0.023391565,
-0.023956189,
0.008812167,
-0.025327418,
0.030247713,
-0.003266753,
-0.011473966,
0.015701924,
0.010922785,
-0.0023290738,
0.011500853,
0.015876688,
0.0037944075,
-0.0039389245,
-0.012166303,
0.02941422,
-0.020339906,
-0.00043439076,
0.014639894,
-0.03422697,
0.014854988,
0.015083526,
-0.0041170497,
-0.014599563,
0.029656202,
0.019035894,
0.0072930595,
0.0026769226,
0.020003822,
0.0065940013,
-0.008032449,
-0.008476081,
-0.0016048092,
0.019277876,
0.014182816,
-0.022087552,
0.013503923,
0.002349239,
0.018377166,
0.015836358,
-0.007004026,
-0.022114439,
-0.008402143,
-0.015970793,
-0.0020064316,
-0.014639894,
-0.0020753292,
0.016548859,
-0.01568848,
-0.0043724747,
0.0034616827,
-0.018699808,
0.02415784,
-0.006721714,
-0.008086222,
0.020649105,
-0.01556749,
0.0142903635,
-0.021818684,
0.0010653917,
0.013712296,
0.022988262,
0.0077366927,
0.00419771,
0.0034684045,
0.008926436,
0.020380236,
-0.016414426,
-0.022020334,
0.011352975,
-0.011279036,
0.009894363,
0.007911458,
0.0147608835,
0.013873618,
-0.032828853,
-0.009269244,
0.009941415,
-0.017839428,
-0.0316996,
-0.024305718,
0.014357581,
0.026295345,
-0.023324348,
-0.010001911,
0.016159,
0.040733587,
0.0064293193,
0.0047993036,
0.017395796,
-0.027854783,
-0.0013577862,
-0.019654293,
-0.003975894,
0.007219121,
-0.003349094,
0.009128087,
0.022598403,
0.010727855,
-0.023243686,
-0.014209704,
-0.0065200627,
0.0011015208,
0.008462638,
0.016696738,
0.024346048,
0.01693872,
-0.0050345636,
-0.026819639,
0.0004726205,
-0.0151910735,
-0.0152314035,
0.018309949,
-0.026066806,
0.0075014327,
-0.0045506004,
-0.010089293,
0.020689435,
-0.0048799645,
-0.02890337,
-0.039711885,
0.007084687,
0.012199911,
0.03180715,
0.014518903,
-0.026443223,
-0.0013351004,
0.010479152,
-0.014465128,
0.02137505,
-0.0151373,
0.009679268,
-0.01035144,
-0.00031739092,
0.02141538,
-0.6474355,
-0.022867272,
-0.0012409964,
-0.028580727,
0.0028987392,
0.02638945,
0.005437867,
0.013396376,
0.00006753222,
0.02446704,
-0.020003822,
-0.0028281612,
0.004369114,
-0.015016309,
-0.053666163,
-0.038770847,
0.012986352,
-0.0242385,
0.042346798,
0.0036230038,
-0.044282652,
0.025340863,
-0.009699433,
0.012401562,
-0.0058915825,
0.02274628,
0.007830797,
0.0050614504,
0.0012561203,
0.012650265,
-0.032022245,
0.00846936,
-0.0188208,
0.016777398,
0.045358125,
-0.008368534,
0.033043947,
0.013954278,
0.007958509,
0.012347789,
-0.009128087,
-0.023095809,
0.030140165,
0.020931417,
-0.0050412854,
0.008630681,
-0.004752252,
0.0064293193,
-0.009692712,
-0.027424593,
0.005716818,
-0.004913573,
-0.004648065,
-0.013053569,
-0.0042850925,
-0.0035826736,
0.02446704,
-0.0208642,
0.008630681,
0.0054681143,
-0.031269412,
-0.0024063736,
0.0030566994,
-0.02565006,
-0.0023509194,
0.008960045,
0.013282107,
0.0032633923,
0.01164873,
-0.022719393,
0.019976934,
0.0370232,
-0.00076963624,
-0.03393121,
0.007689641,
0.014572676,
0.027881669,
-0.009087757,
-0.002807996,
0.012220076,
0.021885902,
-0.000945241,
-0.052698236,
0.009833868,
0.031430736,
-0.0013594667,
-0.01949297,
0.009282687,
0.004604374,
0.004227958,
0.009874198,
0.014545789,
-0.0040767197,
-0.057430323,
-0.029951958,
0.013456872,
-0.022894157,
0.0046581477,
0.014424798,
-0.044148218,
-0.042508118,
-0.0010233809,
0.0028836152,
-0.0056496006,
0.03317838,
-0.0056966525,
0.0013771112,
-0.028580727,
0.027908556,
-0.012280571,
0.008892828,
-0.0072728945,
-0.0041237716,
0.024332605,
-0.00071040116,
-0.03376989,
0.0018568735,
0.019425754,
-0.019721508,
-0.010022076,
0.011514296,
0.019627405,
0.018444384,
-0.023794867,
0.020581888,
0.034092534,
0.008005561,
-0.024386378,
0.003093669,
-0.013806401,
-0.00627472,
-0.020891087,
0.02043401,
-0.0057941177,
-0.0013628275,
-0.014854988,
0.023983076,
0.020662548,
-0.002678603,
-0.028231198,
-0.016535416,
-0.0031457623,
-0.006113399,
-0.00803917,
-0.019976934,
-0.007682919,
-0.027357375,
-0.008220656,
0.021818684,
0.0057941177,
0.012260406,
0.011151323,
-0.015312064,
0.0047152825,
-0.0034331153,
-0.011594957,
0.0016031287,
-0.03729207,
0.000564624,
-0.03188781,
0.02427883,
0.020622218,
0.012690596,
0.007676197,
0.013712296,
-0.009444009,
0.007837518,
0.014841544,
-0.007676197,
-0.012892247,
0.03153828,
-0.027666574,
-0.02043401,
0.009107922,
-0.027559027,
0.01949297,
-0.0007599738,
-0.01113788,
-0.014048383,
-0.02243708,
0.004984151,
-0.028069878,
-0.013611471,
-0.010842125,
0.03635103,
0.022302646,
0.016521974,
0.004190989,
0.01619933,
0.035114232,
0.007192234,
-0.0035322607,
-0.02243708,
0.03379678,
0.0072527295,
0.022141326,
0.024480483,
0.016562304,
0.0065200627,
0.04387935,
0.011453801,
0.016226217,
0.0039456463,
-0.012737648,
0.012045312,
-0.045385014,
0.021791797,
-0.0076022586,
0.0054849186,
-0.0091348095,
-0.015473385,
-0.0064259586,
-0.0082139345,
-0.015634706,
0.006459567,
0.0292529,
-0.018296506,
0.019560188,
0.019775283,
0.0064494847,
0.013665245,
-0.012677153,
0.034415174,
-0.011171489,
-0.011447079,
-0.01662952,
-0.01466678,
0.020259246,
0.017503344,
-0.010633752,
0.009706155,
0.013436707,
-0.014075269,
0.016508529,
0.018807355,
-0.018740138,
0.023512555,
-0.00018642253,
0.022208543,
0.010028797,
-0.002608025,
0.0003768361,
0.0014409674,
-0.007898014,
0.024493925,
-0.009356626,
0.016333764,
-0.0031356795,
-0.011789886,
0.0034381568,
-0.011447079,
-0.014586119,
-0.011729391,
0.0038582638,
0.033070832,
-0.0119780945,
0.01804108,
0.014021495,
0.03540999,
0.030086393,
0.010842125,
0.016562304,
-0.008402143,
-0.017516786,
-0.005387454,
-0.007548485,
0.028822709,
-0.020756653,
-0.012058755,
-0.0016207733,
-0.008731507,
-0.018296506,
-0.010855569,
-0.013335881,
0.008899549,
0.0018383887,
-0.0025273645,
0.031269412,
0.01470711,
-0.03581329,
-0.0407067,
-0.021173399,
0.039550565,
0.020917974,
-0.014922205,
-0.033716116,
-0.007219121,
0.002576097,
-0.02706162,
0.008388699,
0.005901665,
-0.011749556,
-0.006956974,
0.0014737358,
-0.0119780945,
0.005538692,
0.040921796,
-0.008718063,
0.011413471,
0.020326464,
-0.0014107197,
-0.0012057074,
-0.010022076,
-0.03581329,
0.039469905,
0.0002858829,
-0.013470314,
0.0069099218,
0.0115075745,
-0.01611867,
-0.0015468345,
-0.00949106,
0.0014896998,
-0.018888017,
-0.00021950598,
-0.0013947557,
-0.028742049,
0.032855738,
0.02831186,
0.0009385193,
-0.011144602,
-0.022558073,
-0.0071384604,
0.030543469,
0.021092739,
0.008301317,
-0.0065267845,
-0.004090163,
-0.012347789,
-0.005730261,
-0.0110572195,
-0.008166882,
0.026362563,
-0.01415593,
-0.026698649,
0.021280946,
-0.0072594513,
0.02831186,
0.00048816449,
0.019425754,
0.008859219,
-0.02624157,
-0.004553961,
0.00045497602,
-0.035705745,
0.0062814415,
0.01796042,
0.007656032,
0.016804285,
0.008166882,
0.029978845,
0.022558073,
-0.013510645,
-0.015594376,
-0.020917974,
0.01980217,
0.016454756,
0.038555752,
0.014182816,
0.0035356216,
0.0036902209,
-0.016468199,
0.013994609,
0.009571721,
0.022087552,
-0.0019240907,
-0.0002646675,
0.036727447,
0.013114064,
0.0044060834,
0.0096456595,
-0.0033860635,
0.013261942,
-0.013873618,
0.025461853,
-0.0033793417,
-0.021912787,
-0.009504504,
0.014048383,
-0.0019308124,
-0.010768185,
-0.013873618,
-0.0056764875,
-0.018108297,
-0.033070832,
-0.011910877,
0.012099085,
0.0007755178,
-0.004133854,
0.0013040125,
-0.013456872,
-0.010882455,
-0.03530244,
-0.01671018,
0.009007097,
-0.025932373,
-0.029118465,
-0.007642589,
0.017718438,
-0.0010174995,
0.008731507,
-0.008886106,
0.011931042,
0.015446499,
-0.03463027,
-0.011769721,
-0.001776213,
-0.050009552,
0.011480687,
0.0019694623,
0.01117821,
-0.011655452,
-0.016737068,
0.024682134,
-0.0059352736,
-0.0082340995,
0.00898021,
-0.008771837,
-0.0031676078,
0.018175514,
-0.0028130373,
0.013208168,
-0.013564419,
-0.0013250179,
0.018350279,
-0.050170872,
-0.009141531,
-0.048772756,
-0.0030684625,
-0.017704995,
-0.012771256,
-0.005404258,
0.003128958,
-0.014908762,
0.0081736045,
0.005209328,
0.007857684,
0.02831186,
0.03387744,
0.0043321447,
-0.0038885116,
-0.0063049677,
0.00451027,
0.003396146,
0.021186842,
0.0004144357,
0.034415174,
-0.0043657534,
-0.008630681,
0.022934489,
0.011810051,
-0.013382932,
-0.005857974,
-0.00053941755,
0.011736113,
0.041190665,
0.018646035,
-0.023620103,
-0.028338747,
-0.004298536,
-0.0008019845,
-0.012683874,
-0.02341845,
-0.019062782,
0.010942951,
-0.012462058,
0.009820424,
0.003525539,
-0.00097044744,
-0.01988283,
-0.0060293777,
0.012280571,
-0.015513716,
0.009067592,
-0.02070288,
-0.001893843,
-0.027505254,
-0.041782174,
-0.010754743,
-0.029494882,
0.020286134,
0.0016829491,
0.016602634,
0.00490349,
0.018256174,
-0.014895318,
0.013140951,
0.011084107,
0.007709806,
-0.017772213,
-0.013167838,
-0.00029995647,
-0.0055823834,
0.004661509,
0.011480687,
0.0030298126,
0.005760509,
-0.0075148763,
0.04078736,
0.022934489,
0.00020585248,
-0.018404054,
0.0040935236,
-0.036781218,
-0.006466289,
0.00040519334,
-0.00301973,
0.0057974784,
-0.0242385,
0.014613006,
0.022759724,
-0.016777398,
0.021482598,
-0.012690596,
0.015365838,
-0.008308038,
0.009941415,
0.007561928,
0.019129999,
-0.008610516,
-0.010176675,
-0.03788358,
0.0255694,
0.036458578,
0.010358161,
0.014034939,
0.024144396,
-0.00270549,
0.0020618858,
0.015150744,
-0.010922785,
-0.0063352156,
-0.008926436,
-0.0055588577,
-0.00068099366,
-0.020958304,
-0.009202027,
-0.017422684,
-0.0055588577,
0.0077366927,
-0.0009502823,
0.023458783,
-0.0013300591,
-0.008912993,
0.009659103,
0.016212774,
0.008671011,
-0.008287873,
0.019371979,
-0.00015270893,
0.0069166436,
-0.05207984,
-0.0056764875,
0.014411354,
0.011030333,
-0.003090308,
0.030167053,
-0.011527739,
-0.006422598,
0.011063941,
0.0029105023,
-0.03086611,
-0.044739727,
-0.008818889,
-0.0017224392,
0.0077299713,
-0.010344718,
0.004231319,
-0.0059184693,
0.012179745,
-0.008361813,
0.031323187,
-0.0092154695,
-0.030516582,
-0.0041674627,
-0.0027878308,
0.019748395,
0.00780391,
-0.0011216861,
0.011003446,
-0.01419626,
0.0030802255,
-0.013470314,
-0.007662754,
0.014397912,
0.04952559,
-0.016400982,
0.007077965,
0.029575542,
0.010768185,
-0.017274804,
-0.012798144,
-0.0025290449,
0.037856694,
-0.03196847,
-0.0057033743,
-0.022773167,
0.015325508,
-0.0041943495,
0.016871503,
-0.018457826,
-0.015701924,
-0.021778353,
0.01666985,
0.030409034,
-0.010761464,
-0.0026130662,
-0.004984151,
-0.0023425173,
-0.004483383,
-0.036216594,
-0.018484714,
0.015459943,
-0.03984632,
-0.012764535,
0.0038246552,
0.012025147,
0.022638733,
0.02812365,
0.0011737793,
-0.015204517,
0.033097718,
-0.031054318,
0.0147205535,
0.027559027,
0.002443343,
-0.048799645,
0.02517954,
-0.007077965,
-0.013463593,
0.001796378,
-0.0073871636,
-0.014680224,
-0.008086222,
0.005478197,
0.0030382148,
0.019224102,
-0.023754537,
-0.003172649,
0.0072594513,
0.028957143,
-0.006956974,
-0.04352982,
0.013618193,
-0.021912787,
-0.0039389245,
0.016011123,
-0.014693667,
0.018336836,
0.0022853827,
-0.013470314,
0.00929613,
-0.018229289,
-0.025085436,
-0.003039895,
0.010069127,
-0.002537447,
0.014545789,
-0.0030802255,
-0.012058755,
-0.0052059675,
-0.0054177013,
-0.008966766,
0.0021291028,
0.0095649995,
0.017624334,
0.004634622,
0.033043947,
-0.010627029,
0.000054561413,
0.007575372,
0.0010754742,
-0.039443016,
-0.0015417931,
-0.013705575,
0.016508529,
0.030059505,
-0.012885526,
-0.013873618,
-0.0029424303,
-0.025999589,
-0.011030333,
-0.0008662609,
0.013053569,
0.0020585249,
0.03734584,
0.009370069,
0.006227668,
-0.0004545559,
0.018525044,
0.0006360422,
-0.011816774,
0.0042918143,
0.0031424013,
0.007454381,
0.02368732,
-0.03454961,
0.016427869,
0.004278371,
-0.0076022586,
-0.020151699,
0.025797939,
-0.0067049097,
0.004886686,
0.0028701718,
0.0016989132,
-0.009484339,
0.001270404,
0.017355466,
-0.00039153983,
-0.027774122,
-0.000694017,
0.005824365,
-0.028742049,
0.00094440085,
-0.017382352,
0.0095851645,
0.028742049,
-0.04164774,
-0.038206223,
0.0086642895,
-0.030032618,
-0.0104321,
0.020460898,
0.020568445,
0.01329555,
0.009941415,
0.008455916,
-0.019129999,
-0.0046917563,
-0.018713253,
0.005545414,
0.006657858,
0.0023626825,
-0.0040061413,
0.0030180495,
-0.01658919,
-0.011413471,
0.0013191364,
-0.01671018,
-0.009934694,
-0.025582844,
0.015365838,
0.013705575,
-0.011971372,
0.004348949,
0.012643544,
-0.039201036,
0.0012771257,
-0.0014485294,
0.01019684,
-0.02733049,
0.03188781,
-0.005387454,
-0.005760509,
-0.017946977,
0.013040125,
-0.019304764,
-0.00780391,
0.019775283,
0.18874572,
-0.025502183,
0.010963116,
0.03196847,
0.015379282,
0.0012174705,
0.010593421,
-0.0023156304,
0.00784424,
-0.004883325,
0.031753376,
-0.0058142827,
-0.02804299,
0.004953903,
0.026712092,
-0.018793913,
-0.01957363,
-0.02548874,
-0.017678108,
0.01714037,
0.012845196,
-0.008872663,
-0.039120376,
-0.013046847,
0.021254059,
0.008771837,
-0.012556162,
0.0063116895,
-0.0016342168,
0.0072460077,
-0.02933356,
-0.009497782,
0.0027575833,
0.007709806,
-0.017221032,
-0.00023736052,
0.013557697,
0.005168998,
-0.00032096184,
0.018269619,
-0.010727855,
0.005689931,
-0.017449569,
-0.03342036,
-0.008294595,
0.009927971,
0.0025307252,
-0.013436707,
-0.008657567,
-0.0048732427,
-0.020313019,
0.0070241913,
-0.01701938,
0.010754743,
-0.017704995,
-0.017315134,
0.008133274,
0.0049270163,
0.004325423,
0.0054177013,
-0.004066637,
-0.0091146445,
-0.00396245,
0.007965231,
-0.025784494,
0.02992507,
-0.0038750682,
0.00945073,
0.015365838,
-0.0087046195,
0.009457451,
-0.021428823,
-0.0106068645,
-0.0026298705,
-0.009860754,
-0.035705745,
0.028661389,
0.017799098,
0.019304764,
0.01855193,
0.015002865,
-0.006842705,
-0.010129623,
-0.009948136,
-0.014250034,
-0.030167053,
0.019009007,
-0.00902054,
-0.02145571,
-0.010781629,
0.003949007,
0.0040027807,
-0.013114064,
-0.0073737204,
0.015580933,
0.013436707,
-0.012556162,
0.008617237,
-0.005538692,
-0.011144602,
-0.030973658,
0.060925614,
-0.015742254,
-0.0039153984,
0.004231319,
0.0021627115,
-0.007709806,
0.024171283,
0.019425754,
0.0022248873,
0.0091549745,
-0.037668485,
0.0065435884,
-0.020286134,
0.01082196,
0.015043196,
0.022531185,
-0.04651426,
0.025582844,
0.0027643049,
0.012562883,
-0.0025172818,
0.0005663044,
0.036135934,
0.0036801384,
0.006936809,
-0.02133472,
-0.009181862,
-0.009591886,
-0.007850962,
-0.0010536286,
0.010176675,
0.02039368,
0.014223147,
0.015473385,
-0.019855943,
-0.023405008,
-0.02548874,
-0.025246758,
0.0052496586,
0.0032499486,
0.00035814132,
0.010257335,
0.016656408,
0.00081206707,
-0.007575372,
0.037587825,
0.012267128,
-0.0042682886,
-0.00047892213,
-0.009544834,
0.0033238875,
-0.009672547,
-0.009289409,
0.0008847456,
-0.043422274,
-0.008496246,
-0.029763749,
0.006956974,
-0.003996059,
-0.0061906986,
0.00012655726,
0.038475093,
0.011447079,
-0.007682919,
0.0003795668,
-0.17003247,
0.006970417,
0.01568848,
-0.035867065,
0.022383308,
0.022060666,
0.026268458,
0.0020181946,
-0.007077965,
-0.0013771112,
0.02074321,
0.0081736045,
-0.011789886,
-0.007172069,
0.0014090393,
-0.016374094,
-0.020662548,
0.031941585,
0.013194725,
-0.016105227,
0.01376607,
-0.034576498,
0.034253854,
0.002102216,
0.01509697,
0.0013552656,
0.0026970878,
0.01254944,
-0.033017058,
-0.03379678,
-0.009249078,
0.00015165868,
0.002623149,
-0.024184726,
-0.011258871,
-0.0022517743,
0.005195885,
0.012804865,
-0.0016535417,
-0.010553091,
0.028742049,
0.026523884,
0.01611867,
-0.020165142,
0.0024635082,
0.03618971,
0.010727855,
-0.013429984,
0.012334345,
-0.008045891,
0.0016804285,
-0.027854783,
0.018807355,
0.0073871636,
0.039469905,
0.008106387,
-0.017933533,
0.022221986,
0.002423178,
-0.012603214,
-0.017516786,
-0.008583629,
-0.0064091543,
0.00835509,
-0.028930256,
-0.036216594,
-0.027612802,
0.0000745165,
-0.019640848,
0.0038918725,
-0.019748395,
0.007447659,
0.011453801,
-0.0012183107,
0.023821754,
0.028768936,
-0.025717277,
-0.010035519,
0.015540603,
-0.008758393,
-0.019708065,
0.030301487,
-0.008496246,
0.0056193527,
0.019224102,
-0.012979629,
-0.012804865,
0.005552136,
-0.0058646956,
-0.016642964,
0.012307459,
-0.03718452,
0.015473385,
-0.019681178,
0.009054149,
0.017274804,
0.0064394022,
-0.01787976,
0.01941231,
-0.0025004777,
-0.00015564969,
0.0039523677,
-0.015419612,
0.029118465,
0.012179745,
0.00882561,
-0.011521018,
0.016105227,
0.032963287,
-0.005081616,
-0.009161696,
0.011184932,
0.0009208748,
0.007891293,
-0.016454756,
0.016051453,
-0.033904325,
-0.013954278,
0.014545789,
-0.016454756,
0.0648511,
0.0016400982,
-0.011003446,
0.01894179,
-0.0074879895,
-0.0052765454,
-0.13862863,
-0.021751467,
0.0022450525,
0.009396956,
-0.0068527875,
0.011110993,
-0.0057000136,
0.015244847,
-0.03823311,
0.03917415,
-0.022168214,
-0.018646035,
-0.021778353,
-0.008576907,
0.0040296675,
-0.002502158,
-0.0063083284,
-0.003246588,
-0.018565373,
0.033393476,
0.008361813,
-0.015890133,
0.015500273,
-0.014868432,
0.003760799,
-0.01372574,
-0.030839223,
0.0044228877,
0.009249078,
0.015634706,
0.011366419,
-0.030677903,
-0.011655452,
-0.007205677,
-0.01274437,
-0.01074802,
-0.017839428,
-0.0028214394,
0.027209498,
0.011857104,
-0.019788725,
0.000458757,
-0.0020618858,
0.0017913368,
0.01376607,
-0.005458032,
0.003552426,
0.022679063,
0.018121742,
-0.014935648,
-0.011642009,
-0.022840384,
-0.038475093,
-0.017247919,
-0.0091549745,
-0.0040363893,
-0.0302746,
0.004069998,
-0.014854988,
0.008523134,
-0.000037389535,
0.01757056,
-0.020608775,
0.0025004777,
0.01662952,
0.005316876,
-0.018014194,
-0.018914903,
0.019855943,
0.001592206,
-0.0035288997,
0.006812457,
0.00055034034,
0.0028718524,
-0.01961396,
0.0014250034,
-0.033635456,
0.0082340995,
0.0195333,
-0.019143442,
-0.00396245,
-0.021590145,
0.010492596,
-0.019076224,
0.0006713312,
0.01666985,
-0.0009359987,
0.008025726,
-0.0036028386,
-0.01753023,
-0.005209328,
0.032640643,
-0.016521974,
-0.006842705,
-0.044363312,
0.0072796163,
-0.0073804418,
-0.009934694,
0.018188959,
0.03145762,
-0.033285927,
0.000027018139,
-0.057430323,
0.017355466,
-0.003313805,
-0.026806196,
0.01560782,
-0.016306879,
-0.0016098506,
0.0069973045,
-0.0013149353,
0.038259998,
-0.009000375,
0.004110328,
-0.022571515,
-0.017745325,
-0.018390609,
-0.015204517,
0.0102775,
-0.0036028386,
0.040222738,
0.026913743,
0.01804108,
-0.016481644,
0.009531391,
0.01466678,
-0.0077299713,
-0.017987307,
-0.018121742,
0.03506046,
-0.010425379,
-0.009719598,
0.0038011293,
-0.023956189,
-0.015742254,
0.0027995938,
0.00053269585,
-0.019990377,
0.008119831,
-0.012972908,
0.041325096,
0.027518697,
-0.01957363,
-0.0056496006,
-0.016642964,
0.0029525128,
-0.018054524,
-0.0005318556,
-0.009228913,
0.013120785,
0.016521974,
-0.00258786,
0.050843045,
-0.008966766,
0.006419237,
-0.032533094,
-0.030597242,
-0.017301692,
-0.0067049097,
-0.00096372573,
0.012294015,
-0.023579773,
0.042776987,
0.012441892,
0.007575372,
0.012307459,
-0.0061537293,
-0.004775778,
0.02262529,
0.034791593,
0.0026130662,
-0.02544841,
-0.0070443563,
-0.003596117,
0.0030768646,
0.002584499,
0.0105262045,
-0.018404054,
0.011211819,
-0.0017182381,
0.0033188462,
0.007703084,
-0.0014728956,
0.0005364768,
0.01603801,
0.0015048237,
0.032640643,
-0.012811587,
-0.004604374,
0.014962535,
-0.009968302,
0.006365463,
0.002769346,
0.010149788,
0.020877644,
0.022638733,
0.0056193527,
0.033984985,
0.014868432,
0.00008165832,
0.022302646,
0.025878599,
-0.009148253,
-0.0063352156,
0.0038885116,
-0.012347789,
-0.0151373,
0.031350072,
-0.0094104,
-0.028634502,
0.006244472,
-0.00007220591,
0.028526954,
0.008455916,
-0.022342978,
0.0020518033,
-0.025784494,
0.018914903,
0.009457451,
-0.0051152245,
-0.015930463,
0.008200491,
0.02239675,
0.020850757,
0.004043111,
-0.019116554,
0.01368541,
-0.0050143986,
0.02544841,
-0.012656988,
0.010983281,
-0.010479152,
0.0091348095,
0.009739764,
0.000118050106,
0.001270404,
-0.013167838,
0.019170329,
-0.008321482,
0.013503923,
-0.009376791,
0.07248697,
0.016132114,
-0.015796028,
0.012462058,
-0.038179334,
0.012482223,
0.02266562,
0.01306029,
-0.0012872083,
-0.02642978,
0.0046077347,
-0.018753583,
-0.013382932,
-0.04396001,
0.0032247424,
0.01666985,
-0.009390234,
-0.004375836,
-0.004775778,
-0.016495086,
0.015634706,
0.020111369,
0.014680224,
0.030624129,
-0.029978845,
-0.0055487747,
0.01863259,
-0.0012586409,
-0.0073871636,
-0.024937559,
0.011346254,
-0.0016342168,
-0.033070832,
-0.013416541,
-0.0056697656,
-0.0023576412,
0.02906469,
0.0016963925,
-0.006600723,
0.024722464,
0.02462836,
-0.011010167,
-0.019896273,
-0.027827896,
0.0042582056,
-0.0012359552,
0.0075820936,
-0.020460898,
0.023015149
] |
Cardiovascular disease (CVD) is the leading cause of death worldwide. Recent genome-wide association (GWA) studies have pinpointed many loci associated with CVD risk factors in adults. It is unclear, however, if these loci predict trait levels at all ages, if they are associated with how a trait develops over time, or if they could be used to screen individuals who are pre-symptomatic to provide the opportunity for preventive measures before disease onset. We completed a genome-wide association study on participants in the longitudinal Bogalusa Heart Study (BHS) and have characterized the association between genetic factors and the development
|
[
-0.01756854,
0.0012377981,
0.01986903,
-0.029405136,
-0.029944915,
0.0103393495,
-0.009703181,
0.008854955,
-0.02115422,
0.0034539467,
-0.012896876,
0.01247919,
-0.009812421,
0.00637454,
0.002801713,
0.017465726,
0.038298648,
-0.015113828,
0.040123615,
-0.018326802,
-0.020665847,
0.017607097,
-0.0040547727,
-0.023364745,
0.0044981632,
0.03675642,
0.017542835,
-0.024984084,
-0.020190326,
-0.015100976,
0.006978579,
0.00066187256,
-0.018005505,
-0.032746628,
0.002178396,
-0.0024627442,
0.0031053391,
-0.009015604,
-0.0017044825,
-0.008861382,
-0.011065481,
0.011682373,
-0.0070042824,
-0.008707158,
-0.006008261,
0.014676863,
0.0055455924,
-0.035368413,
-0.011855873,
0.03439167,
0.011894428,
0.019714806,
0.0022089195,
-0.0020016825,
0.003148714,
-0.010377905,
0.0030346536,
0.009722458,
0.007524784,
-0.025678085,
0.00064500445,
-0.020331698,
-0.021745406,
0.0039166147,
-0.025356788,
-0.0013831852,
-0.014291307,
0.043593626,
0.008957771,
0.029328024,
0.02055018,
0.015859239,
0.011521723,
0.029739285,
0.0117723355,
0.0009229267,
-0.02205385,
-0.0034346688,
-0.022220926,
0.011489593,
0.0008795515,
-0.01628335,
0.011116889,
0.03554834,
0.00851438,
-0.0072998763,
-0.004803396,
0.004755201,
-0.016668908,
-0.0072613205,
-0.009465421,
0.009574662,
-0.0059954086,
0.014574048,
0.0020450577,
-0.02197674,
0.01095624,
0.009124845,
0.0024900546,
-0.030844547,
-0.018005505,
0.0036949196,
-0.008771418,
-0.011213278,
-0.028891059,
0.0069143195,
-0.024945527,
0.008745714,
0.012254282,
-0.010101589,
-0.013083229,
0.04009791,
-0.01030722,
-0.007955323,
0.014329863,
-0.031384327,
0.012357097,
0.0101080155,
0.006201039,
-0.002128595,
0.020228881,
-0.010705628,
0.022670742,
-0.0067729484,
-0.0035953175,
0.0054331385,
-0.03906976,
0.007813952,
0.012337819,
-0.008193083,
0.0013976436,
0.0024097303,
-0.0024370404,
-0.0136230085,
-0.03351774,
0.0032193996,
-0.014342714,
0.0003586482,
-0.015358014,
-0.038581386,
0.011765909,
0.029970618,
-0.028531207,
-0.016321907,
-0.00012470354,
0.031024475,
0.030150546,
0.018211136,
0.015447977,
-0.0031760244,
0.002692472,
-0.011476742,
0.031718478,
-0.015512237,
-0.012357097,
0.009002753,
0.0010289549,
0.015088124,
-0.0069721527,
-0.016501833,
0.0008916002,
0.0019293907,
0.0011269505,
0.018069765,
0.008822826,
0.017272947,
-0.0071392274,
-0.025523864,
0.019406362,
-0.024598526,
-0.023686042,
0.033877593,
-0.0637968,
0.028531207,
0.008283046,
0.0055584447,
0.00021145384,
0.012524172,
-0.031230103,
-0.013738675,
-0.020447364,
0.020061808,
0.022272334,
0.000947024,
-0.011888003,
0.0066508553,
0.026809052,
-0.0012410111,
0.002138234,
-0.04618971,
-0.022567928,
0.017041612,
0.0045013763,
-0.017619947,
-0.65637195,
-0.0053142584,
-0.007466951,
-0.019187879,
0.0016249614,
0.029482245,
0.019830473,
0.022040999,
-0.0074798027,
0.038350053,
-0.013687268,
0.015756423,
0.0012691246,
-0.007094246,
-0.009844551,
-0.03811872,
0.007582618,
-0.009465421,
0.020473069,
0.017825577,
-0.0063070673,
0.027785797,
-0.014419826,
0.010795591,
-0.00075585203,
0.027965723,
0.0021334146,
-0.012215726,
-0.0038844852,
0.023261929,
0.022966336,
0.012639838,
-0.0010450197,
0.018840877,
0.048400234,
-0.020871477,
0.003283659,
0.016231943,
0.0032113672,
0.039249685,
-0.02142411,
-0.0070299865,
0.01268482,
0.011251834,
-0.01143176,
0.021192774,
0.013481637,
0.022092408,
0.013533046,
-0.024380045,
0.00039499495,
-0.00512148,
-0.004263616,
-0.004025856,
0.00973531,
-0.0045688488,
0.03886413,
-0.025768049,
-0.0005927936,
-0.0006144812,
-0.017748466,
0.020473069,
0.014214195,
-0.008822826,
-0.0032210061,
0.0016707462,
-0.013558749,
0.020665847,
-0.0031133716,
-0.019509176,
0.005015452,
0.020318845,
0.0003367598,
-0.0031438947,
0.038992647,
0.030201953,
0.017517133,
0.02827417,
-0.025356788,
0.010493572,
-0.01384149,
-0.006339197,
0.0038844852,
0.03315789,
0.014098529,
0.011997243,
-0.0013614976,
0.01756854,
-0.007306302,
0.010262238,
0.0034475208,
0.0067536705,
-0.008835678,
-0.03418604,
0.0031953023,
0.030818844,
-0.006978579,
0.0032627748,
0.008610769,
-0.003131043,
-0.012909728,
-0.0021334146,
-0.016861686,
0.01108476,
0.0023149475,
0.013044673,
-0.033235,
-0.010043756,
0.03770746,
-0.024405748,
-0.02360893,
0.0025093325,
-0.009812421,
-0.0054106475,
-0.0049351277,
-0.025408195,
-0.010172275,
-0.015936349,
0.00949755,
-0.023660338,
0.02394308,
0.019097915,
0.0133916745,
-0.03099877,
0.0028820373,
-0.005500611,
-0.008495103,
-0.00925979,
0.009343327,
-0.015769275,
0.0050475816,
-0.024649935,
0.011534575,
-0.0035117802,
-0.00646129,
-0.021604035,
0.016411869,
0.011534575,
-0.023711747,
-0.004180079,
0.0056708986,
-0.019072212,
0.006120715,
0.009221234,
-0.012157893,
0.008636474,
-0.008739288,
-0.010095163,
-0.023274781,
-0.028891059,
0.013880046,
-0.02089718,
-0.016437573,
0.006554466,
-0.0056741117,
-0.0050764983,
0.01682313,
-0.0169645,
-0.008520806,
-0.017452873,
0.02286352,
-0.018776618,
-0.0067793746,
0.005597,
0.0043375143,
-0.014753975,
-0.015884941,
0.02482986,
-0.02116707,
-0.02034455,
0.016141979,
-0.028865356,
0.002062729,
0.010628517,
-0.0010490359,
0.016039165,
-0.0069914307,
0.00082211965,
-0.019213583,
-0.015190939,
-0.0057608616,
-0.0393268,
-0.025960827,
-0.01512668,
0.019907584,
0.0062781507,
0.0024755963,
0.0035953175,
0.019175027,
0.024238674,
-0.015884941,
0.014638308,
-0.051741727,
0.009163401,
0.012427782,
0.002804926,
-0.00019478652,
0.00401943,
0.004000152,
0.009266216,
0.019252138,
-0.011566705,
0.013186044,
0.0020370253,
0.02197674,
-0.015910646,
0.0046941545,
-0.0007185012,
-0.008597918,
0.009966644,
0.012794062,
-0.0026410643,
0.0069850045,
-0.01485679,
0.0018394274,
0.013378822,
-0.006682985,
-0.008880659,
-0.005131119,
-0.0074990806,
0.016578944,
-0.000577532,
0.035908192,
-0.024161562,
-0.0062749377,
0.026423495,
-0.010949815,
0.021462664,
-0.0049865353,
-0.02448286,
-0.014124232,
0.0077239885,
0.004122245,
0.0001385595,
-0.016977353,
-0.010519275,
-0.023788856,
-0.015011013,
0.021475516,
0.019701954,
-0.0011245408,
-0.028865356,
-0.0033222148,
0.0060468162,
0.012164318,
-0.0011438186,
0.02590942,
0.002927019,
-0.0077304146,
0.01905936,
-0.011663094,
-0.000622112,
-0.0029543294,
-0.0058861678,
-0.012029373,
-0.029122394,
0.00789749,
0.0065351883,
0.031769883,
0.018506728,
0.04469889,
0.009503976,
-0.021822518,
-0.012022948,
-0.004996174,
-0.0026651616,
-0.011457464,
0.0129290065,
0.005641982,
-0.00452708,
-0.02162974,
-0.009028456,
0.0072227647,
-0.056805376,
-0.0009871862,
0.018892284,
0.01709302,
0.005362453,
0.01065422,
0.0072420426,
0.009992348,
-0.019419214,
0.011553854,
0.022542223,
-0.025459602,
-0.022246629,
0.015216643,
-0.004896572,
-0.02191248,
0.029405136,
-0.00050965796,
0.008552936,
0.0025703788,
-0.022015296,
0.0038941242,
-0.006432373,
0.005172888,
-0.011997243,
0.008501529,
-0.00096148235,
-0.015255199,
0.0006365704,
-0.0020498773,
-0.012312115,
0.020023253,
0.016270498,
-0.015769275,
0.017414317,
0.022259481,
0.0024707767,
0.0003640701,
-0.020640142,
-0.0052210824,
-0.011328945,
-0.0047327103,
0.026603421,
-0.008803548,
0.011444612,
0.012980414,
-0.0019920436,
0.0057062414,
-0.028042834,
-0.015859239,
-0.019766213,
0.06888615,
0.00023334222,
-0.02189963,
0.0076211737,
-0.0139443055,
0.009825273,
-0.003315789,
-0.03045899,
0.027914315,
0.028634021,
0.009047734,
-0.012948284,
0.015705016,
0.006008261,
0.002676407,
0.029764988,
0.01384149,
-0.029867804,
-0.024701342,
0.009401161,
0.0005915888,
-0.013507341,
0.024033044,
0.044853114,
0.024791304,
-0.02075581,
0.008398714,
0.021719702,
-0.008417991,
-0.0033479186,
-0.014496937,
0.01947062,
-0.008797122,
0.03364626,
-0.0020546967,
0.010332923,
0.013076803,
0.016437573,
0.009079863,
0.010834147,
0.02516401,
-0.015203792,
-0.0057255193,
0.011746632,
0.028916763,
-0.010538554,
0.03207833,
0.010859851,
0.018339654,
-0.015306607,
0.028171353,
-0.0091376975,
-0.005211443,
-0.025048343,
0.03724479,
-0.024791304,
-0.0028274169,
-0.006120715,
-0.0024836287,
-0.015370866,
-0.014265603,
-0.032643814,
-0.008739288,
0.009465421,
0.0007526391,
0.0011430153,
-0.032720923,
-0.0075183585,
-0.008193083,
-0.014689716,
0.009426865,
-0.00681793,
-0.004260403,
-0.009979496,
0.019277843,
0.011900854,
0.027040387,
-0.013738675,
0.010532128,
0.01349449,
-0.0053142584,
0.0041061803,
-0.0120036695,
-0.015923498,
0.00039640063,
-0.0009928088,
-0.0077689704,
-0.016514685,
0.006352049,
0.03601101,
-0.0057030283,
-0.000015023162,
0.018288245,
-0.009741737,
-0.0007397872,
0.02062729,
0.022580778,
0.0015759636,
-0.007871785,
-0.0069335974,
0.007524784,
-0.014715419,
-0.0077111367,
-0.033800483,
0.010082311,
-0.024058746,
-0.0023535031,
-0.021205626,
0.021886777,
-0.016090572,
0.0083023235,
-0.022606483,
0.019856177,
0.0019390297,
0.019367805,
0.022889225,
0.032052625,
0.02360893,
0.008572213,
-0.008218787,
-0.005037943,
0.015884941,
0.019457769,
0.0020563032,
-0.01512668,
0.017581392,
0.00547812,
-0.013970009,
-0.0312044,
0.009863829,
0.006920745,
0.021758258,
-0.00076709746,
-0.018532433,
-0.030510398,
0.013738675,
0.018481024,
-0.00012831813,
-0.006143206,
-0.012537023,
-0.020113215,
-0.0026282126,
-0.0031406817,
-0.021668294,
0.058141973,
-0.033363517,
0.0055295276,
-0.023416152,
-0.006766523,
0.0019309971,
-0.028865356,
-0.014329863,
-0.0200104,
-0.01675887,
-0.0021253822,
-0.023249077,
0.0019679463,
-0.012376375,
0.016668908,
0.006920745,
0.01533231,
-0.0018056912,
0.013006117,
0.026603421,
0.02232374,
-0.010075886,
-0.0050283037,
-0.008957771,
-0.010030904,
0.023429004,
0.023647485,
0.014895346,
-0.0040772636,
-0.014008565,
0.015345162,
0.01579498,
-0.0051054154,
-0.028505502,
-0.017015908,
-0.036910642,
-0.014702568,
-0.011129741,
-0.008906363,
0.011888003,
-0.049711127,
-0.004041921,
0.035805378,
0.0005779336,
0.0036884937,
-0.010030904,
0.008205934,
-0.012164318,
0.033312112,
-0.0014145117,
0.0056741117,
0.004164014,
-0.028454095,
-0.007916767,
0.015537941,
0.019432064,
-0.004652386,
0.021539776,
0.021115663,
-0.01376438,
-0.0013213354,
0.009613217,
-0.046215415,
-0.0024000914,
0.00066870014,
-0.028299872,
0.01831395,
-0.035368413,
-0.0152423475,
-0.007993879,
0.00083296344,
0.0031197974,
-0.021321293,
0.026886163,
-0.016257647,
-0.011438186,
-0.008424417,
0.010262238,
0.0007301483,
-0.024328636,
0.036936346,
0.00043616118,
-0.015499385,
-0.03439167,
0.030690324,
0.0179798,
0.005115054,
0.01831395,
-0.004102967,
-0.019072212,
-0.012138614,
0.024302933,
0.036370862,
-0.046703786,
-0.027425943,
0.018146874,
-0.007858934,
-0.0065801702,
0.013301711,
-0.006747245,
-0.02516401,
0.008334454,
-0.0010088737,
-0.005172888,
-0.004135097,
-0.034674414,
0.017067317,
-0.0015414241,
-0.027297424,
0.013828639,
0.017182983,
-0.022388,
0.004266829,
0.0028756114,
0.008912789,
0.004504589,
0.019444916,
0.02143696,
-0.00086107693,
-0.0013582846,
0.009163401,
0.016951649,
0.014484085,
0.014779679,
-0.018570988,
0.038427167,
-0.0027165692,
-0.01190728,
0.00056548335,
-0.017928394,
0.0059600663,
0.024971232,
-0.01512668,
-0.021925332,
-0.0069914307,
-0.031821292,
0.020395957,
0.0026346385,
0.0021751833,
0.014869642,
-0.027066091,
-0.024727045,
-0.020305993,
-0.023865968,
0.026025087,
-0.038144425,
-0.008687881,
-0.015884941,
-0.003656364,
0.014059973,
0.010589961,
-0.0016177322,
-0.008610769,
0.030844547,
-0.016784575,
0.027246017,
0.0012257495,
0.0022105258,
-0.023724597,
0.028351279,
-0.017118724,
-0.01438127,
0.003772031,
0.005613065,
-0.027348831,
-0.03770746,
-0.0027936806,
0.00685006,
0.002673194,
0.0011622933,
0.012427782,
0.012537023,
0.0008715191,
0.0020209604,
-0.015537941,
0.02909669,
-0.015280902,
0.0016787788,
0.037938792,
-0.013327415,
0.01858384,
-0.0030073433,
0.025151158,
0.0060307514,
-0.0024820222,
-0.034700114,
-0.01736291,
0.0406891,
0.017915541,
0.0043214494,
-0.010191552,
-0.009067012,
-0.02536964,
0.014484085,
0.0050411555,
-0.025215417,
0.007524784,
-0.0076211737,
-0.010840573,
0.019149324,
-0.009047734,
0.0010554618,
-0.0064452253,
-0.023480412,
-0.024521414,
-0.0030683898,
-0.0059343623,
0.027580166,
0.03161566,
-0.010313645,
-0.019252138,
-0.0034507336,
-0.036268048,
-0.0026442774,
0.015537941,
0.027503055,
0.0041961437,
0.030433286,
-0.003415391,
0.030022025,
-0.010962666,
0.02191248,
0.00082412775,
-0.0049608313,
0.023429004,
-0.0011349829,
0.017067317,
0.0064998455,
-0.015383718,
0.0038780593,
0.01986903,
-0.009536106,
-0.025408195,
-0.008077416,
0.003675642,
0.0021542988,
-0.0017109085,
0.01241493,
-0.012761932,
-0.002088433,
0.0002963968,
-0.023788856,
-0.009696755,
-0.0035631878,
-0.0057929917,
-0.003049112,
-0.012067929,
-0.0038941242,
-0.0024370404,
-0.0052178693,
-0.03559975,
-0.024020191,
0.020665847,
-0.009221234,
0.00532711,
0.005115054,
0.0045977654,
0.026025087,
0.009446142,
0.013288859,
-0.02143696,
-0.020768661,
0.008700733,
-0.013815787,
-0.0018490663,
-0.003791309,
-0.00050845306,
-0.0043632183,
0.011187574,
-0.012839043,
-0.02292778,
-0.030536102,
-0.027940018,
-0.021963889,
0.028582614,
-0.00077231857,
0.009266216,
0.00610465,
0.012247856,
-0.038504276,
0.0029254125,
-0.020126067,
0.0028659725,
-0.012678394,
-0.009863829,
0.016373314,
0.00390055,
-0.022542223,
0.005462055,
-0.023184817,
-0.016578944,
0.01336597,
0.18969397,
-0.011547428,
-0.017131576,
0.012074355,
-0.0030266212,
-0.008328028,
0.033183593,
-0.0075055063,
-0.0027374537,
0.0022828178,
0.012524172,
-0.0026603423,
-0.007858934,
0.00610465,
0.008495103,
-0.032926556,
-0.022156667,
-0.018673804,
0.011553854,
-0.017118724,
0.016476128,
-0.0017446447,
-0.0103843305,
-0.008283046,
0.03141003,
0.0023743876,
-0.006098224,
0.016578944,
0.02129559,
0.0038234387,
-0.0044435426,
0.003005737,
0.004157588,
0.016810277,
-0.0036852807,
0.0028033196,
-0.0096903285,
-0.02333904,
0.020807218,
0.0056548337,
-0.003283659,
0.017555688,
-0.035111375,
-0.0052018045,
0.0043214494,
0.025523864,
-0.004751988,
-0.017324354,
-0.018339654,
-0.0084886765,
-0.037887387,
0.009928089,
-0.0052403603,
0.0074990806,
-0.0057672877,
0.013018969,
0.004761627,
0.0071392274,
-0.0039648097,
0.0064227344,
0.006316706,
-0.0069078933,
-0.029148096,
0.018686654,
-0.017684206,
0.040740505,
0.00011064678,
0.00079962885,
0.008019582,
-0.02549816,
0.004022643,
-0.014895346,
-0.009433291,
0.0062685115,
-0.003788096,
-0.019779066,
0.019971844,
0.008854955,
0.002623393,
0.01947062,
0.0057640746,
-0.023454707,
-0.02408445,
0.00065384014,
-0.021012848,
-0.04559852,
0.009645347,
0.0010402002,
-0.034674414,
-0.014149936,
0.0057030283,
-0.0026314254,
-0.016874537,
0.00824449,
0.034700114,
0.012903302,
-0.009902385,
0.0137129715,
0.031795587,
-0.009626069,
-0.008462973,
0.07217624,
0.0010136932,
0.008115971,
0.008867808,
0.007319154,
-0.024045896,
0.010095163,
0.025446752,
-0.004803396,
-0.01384149,
-0.02752876,
-0.008540084,
-0.014831087,
-0.031127289,
0.029430838,
0.01851958,
-0.02801713,
0.0053206845,
-0.01057711,
-0.0007068542,
-0.0070299865,
0.010744184,
0.04762912,
0.01580783,
-0.020203179,
-0.011997243,
-0.011091185,
-0.011688798,
-0.034802932,
-0.0019293907,
-0.015962053,
-0.019920437,
-0.017825577,
0.0040740506,
0.0064227344,
0.0041126064,
0.0037238365,
-0.011585983,
0.021963889,
-0.007833229,
-0.023596078,
0.008437268,
0.0091376975,
0.022555076,
-0.017954096,
0.0058026304,
0.0034860764,
-0.017555688,
-0.0032001217,
-0.007569766,
-0.002276392,
-0.0054010088,
0.014252751,
0.030638916,
-0.009253364,
0.0012313721,
-0.034031816,
0.0052789156,
0.0007646877,
-0.017915541,
0.022555076,
0.041023247,
-0.0066765593,
0.012035799,
0.00014147125,
-0.16090572,
0.033671964,
-0.0046780896,
-0.008797122,
0.015640756,
0.017658504,
0.02056303,
0.0060211127,
0.00082091475,
0.013083229,
0.04151162,
-0.019457769,
-0.0004662828,
0.008424417,
0.013777231,
-0.018262543,
-0.022670742,
0.052204397,
0.004388922,
0.010320071,
0.01298684,
0.0014361992,
0.011303241,
-0.017144427,
0.00535924,
-0.013597305,
0.009915236,
0.02930232,
-0.023917375,
-0.024264377,
-0.028582614,
0.0031342558,
0.02265789,
-0.002478809,
-0.022105258,
-0.0065416144,
-0.015666459,
-0.038427167,
0.007344858,
-0.009728884,
0.039635245,
0.026166458,
-0.007878211,
-0.025138306,
-0.014805383,
0.014265603,
-0.0059215105,
-0.028531207,
0.023698894,
0.0042443383,
0.0032643813,
0.018468173,
0.0126526905,
0.0049865353,
0.023429004,
-0.0053335363,
-0.0118622985,
0.026089346,
-0.012402078,
-0.018879434,
-0.021526923,
-0.0060596685,
0.013327415,
0.022606483,
0.009883107,
-0.013533046,
-0.029867804,
-0.0007197061,
-0.015178087,
0.012504893,
-0.022349445,
-0.008790696,
-0.00028234007,
0.0011904067,
0.038889833,
0.01804406,
-0.013558749,
-0.00413831,
-0.0071649314,
-0.01224143,
-0.00729345,
-0.0075890436,
-0.015139532,
-0.025253974,
0.0016442393,
0.0072677466,
0.01241493,
0.0018538858,
-0.0008401926,
-0.009966644,
0.0005751223,
-0.034571595,
0.0083023235,
-0.014509789,
0.00051929685,
0.014484085,
-0.0059182975,
-0.0026619488,
0.0074990806,
0.012556301,
0.004135097,
-0.004758414,
-0.013237451,
-0.0061785486,
0.033312112,
-0.016630352,
-0.00074661477,
0.006959301,
0.034417372,
-0.00025081277,
0.0066380035,
0.021488369,
0.00571588,
0.017658504,
0.0020257798,
0.008167379,
-0.012434208,
-0.018429616,
0.005490972,
-0.030073434,
0.058090564,
0.0030266212,
-0.0034828635,
0.040200725,
0.0026426709,
-0.0060532424,
-0.11309668,
-0.003131043,
0.0019550945,
-0.0059215105,
0.00011044597,
0.033260703,
-0.0064066695,
0.025112603,
-0.005115054,
0.031332918,
-0.015486533,
-0.030407583,
-0.015756423,
0.005641982,
0.025408195,
-0.01143176,
0.00025061195,
-0.0036081695,
-0.037810273,
0.023801709,
-0.015049568,
-0.03364626,
-0.002326193,
-0.011438186,
-0.018930841,
0.00043897252,
-0.017118724,
0.0135716,
0.005641982,
0.015293755,
0.0057672877,
0.012138614,
0.00097353105,
0.006416308,
-0.027631573,
-0.017131576,
0.017517133,
-0.04436474,
0.03446878,
0.00033716141,
0.007640451,
0.015820682,
0.019727658,
0.0050475816,
0.00133981,
0.0021751833,
-0.013481637,
0.02062729,
0.0014450349,
-0.011476742,
0.010917684,
-0.033389222,
-0.027760092,
-0.009928089,
-0.023416152,
-0.0261279,
-0.0018619183,
-0.004125458,
-0.0028145649,
-0.000041693354,
0.00595364,
0.0071199494,
-0.018840877,
-0.0038298646,
0.013404526,
-0.01926499,
-0.008617195,
-0.021205626,
0.010789165,
-0.041151766,
-0.00539137,
-0.0022892437,
-0.0117723355,
0.010101589,
-0.03554834,
0.008109545,
-0.028042834,
0.0070171347,
0.021719702,
-0.03567686,
-0.025858013,
-0.0186481,
0.031152993,
-0.027297424,
0.021192774,
0.017260095,
-0.0035696137,
-0.0060564554,
-0.013198895,
-0.0135716,
-0.00007605711,
0.04233414,
-0.011322519,
-0.019830473,
-0.0010193159,
0.018506728,
0.017170131,
-0.0038105869,
0.014535493,
-0.008707158,
-0.014021417,
-0.0026812265,
-0.047860455,
0.025382493,
0.011412483,
0.0007538439,
-0.011238982,
-0.0132246,
0.022850668,
0.007036412,
-0.003643512,
0.013018969,
0.010769888,
0.008250916,
0.0028756114,
0.009491124,
-0.024457155,
-0.010056607,
0.028608318,
0.022735002,
0.048682977,
0.018596692,
0.014034269,
0.018095467,
0.0054556294,
0.030561805,
-0.004218634,
-0.0011638997,
-0.007794674,
0.028916763,
-0.021809665,
-0.012806913,
0.031024475,
-0.030741733,
0.010140145,
0.013957158,
-0.000544599,
-0.010178701,
-0.01539657,
0.011335371,
0.020922884,
0.04009791,
0.005873316,
-0.008443695,
-0.013134636,
-0.014535493,
-0.0039648097,
0.015910646,
-0.04888861,
0.01485679,
0.016039165,
-0.012164318,
0.010467868,
0.0076340255,
-0.01014657,
-0.03369767,
-0.03675642,
0.009632495,
0.015229495,
-0.004398561,
0.019650547,
-0.034263153,
0.026140753,
0.014291307,
-0.0017558901,
0.0071520796,
0.017748466,
-0.03302937,
0.0020466642,
0.004552784,
0.005850825,
-0.013173192,
-0.020948589,
-0.001313303,
-0.0078011,
0.0036210213,
-0.0069143195,
-0.0097802915,
-0.0040836893,
0.0060596685,
-0.02855691,
0.030844547,
0.008501529,
0.014599753,
-0.018840877,
0.034237448,
0.018069765,
-0.0038041607,
-0.0035246322,
-0.0012032586,
-0.0033125759,
0.011116889,
-0.018699506,
0.020935737,
-0.002557527,
0.016231943,
0.002273179,
0.03045899,
-0.006027539,
-0.010249386,
0.015113828,
0.0077496925,
-0.01336597,
0.016951649,
-0.027940018,
-0.019110767,
-0.0028065324,
0.013507341,
0.00058516284,
-0.030201953,
-0.019252138,
-0.0015076878,
0.035805378,
0.038581386,
-0.012626987,
-0.00554238,
-0.012222152,
0.0048901457,
0.007081394,
-0.0007662942,
-0.018481024,
0.031384327,
0.014201344,
0.029199505,
-0.011682373,
0.012273559,
0.0100052,
0.0019181452,
0.0154736815,
0.0033254276,
0.028376983,
-0.002808139,
0.011046204,
-0.0065480405,
-0.018288245,
0.01122613,
0.0019695528,
-0.017478576,
0.013211748,
-0.0019872242,
-0.026809052,
0.058501825,
0.017350057,
0.009381883,
-0.00875214,
-0.016707463,
0.017337207,
0.021835368,
0.018326802,
-0.0032900851,
-0.02162974,
-0.005037943,
-0.029430838,
-0.0014570835,
-0.046112597,
-0.022156667,
0.021886777,
0.0027310275,
-0.0016900242,
0.014265603,
-0.014394122,
0.010969092,
-0.006416308,
0.03207833,
0.018134024,
-0.0189951,
-0.028685428,
0.044261925,
-0.0016932371,
-0.016103424,
0.016309055,
0.0098317,
0.0019197518,
-0.010969092,
0.01363586,
0.010596387,
-0.0056869634,
-0.009176252,
-0.037399013,
0.0018522793,
-0.0049094236,
0.004523867,
-0.0016482555,
-0.026320681,
-0.026603421,
-0.004292533,
-0.0013357938,
-0.016604647,
-0.021179922,
-0.020164622
] |
Epidermal homeostasis depends on a balance between stem cell renewal and differentiation and is regulated by extrinsic signals from the extracellular matrix (ECM). A powerful approach to analysing the pathways involved is to engineer single-cell microenvironments in which individual variables are precisely and quantitatively controlled. Here, we employ micropatterned surfaces to identify the signalling pathways by which restricted ECM contact triggers human epidermal stem cells to initiate terminal differentiation. On small (20 μm diameter) circular islands, keratinocytes remained rounded, and differentiated at higher frequency than cells that could spread on large (50 μm diameter) islands.
|
[
-0.002611182,
0.010938335,
-0.0008152745,
-0.022205742,
-0.017401299,
0.007733179,
-0.014900355,
0.006005554,
-0.013235253,
-0.014215887,
0.031380255,
-0.0058278553,
-0.011754432,
0.00681836,
-0.020665687,
0.0110568,
0.03938327,
0.0034848666,
-0.013557743,
0.0275367,
-0.04749159,
0.022508487,
-0.0030833995,
-0.02067885,
-0.024956778,
0.025075244,
0.0049393624,
-0.04098914,
-0.0031623766,
-0.026431018,
0.0029994862,
-0.0043141264,
-0.007377782,
0.007818738,
-0.014558121,
0.027141813,
-0.007818738,
-0.011793921,
0.021113224,
-0.0014166526,
0.0015260688,
0.00062235637,
-0.0039916364,
-0.027062835,
-0.000012700101,
-0.0034881574,
0.006640662,
-0.00962863,
-0.019099306,
0.033512637,
0.016374595,
0.012366505,
-0.020915782,
-0.0134721855,
-0.020784153,
-0.0041397186,
0.027510373,
-0.004725466,
0.013057555,
-0.012840368,
0.0010291709,
0.014729238,
-0.012333598,
0.0095628165,
-0.006120729,
0.021587087,
-0.0034025987,
0.0010020225,
0.0055284,
-0.0008876702,
0.028484425,
0.0027296476,
-0.017559253,
-0.0001863367,
0.0066143363,
-0.01902033,
-0.0023545062,
0.009352211,
0.0037843217,
0.0062951366,
0.0018674805,
-0.018230557,
-0.019283587,
0.0211922,
0.010786962,
0.0027987526,
-0.020863129,
-0.00037925484,
0.032117374,
0.0042812196,
0.011945293,
0.027352419,
0.011484593,
0.0005186989,
-0.022468999,
0.0077858306,
0.0014076032,
0.031485558,
0.017032739,
-0.0073382934,
-0.017414462,
0.012577111,
-0.0037974846,
-0.026378367,
-0.03311775,
0.008325508,
0.014255375,
-0.02017866,
0.03448669,
0.0013171085,
-0.03135393,
0.015584824,
0.0027872352,
-0.03451301,
0.014650261,
0.010319681,
0.0067854533,
0.0077858306,
-0.024614545,
0.0023035002,
0.011478012,
0.037803728,
-0.0010925172,
-0.03625051,
0.023416724,
0.01861228,
0.0006388099,
-0.0051137703,
-0.01855963,
0.0072593163,
0.006410312,
-0.017006412,
0.007720016,
0.010517123,
-0.020626199,
-0.02215309,
-0.0035572622,
-0.007502829,
-0.018994004,
-0.024851475,
0.014005281,
0.008588765,
-0.010332843,
0.013926304,
-1.9924248e-7,
0.005393481,
0.012471808,
0.013478766,
0.012748227,
0.02399589,
0.0131299505,
-0.015334729,
0.021310667,
-0.02532534,
0.008740137,
0.019836428,
0.019875916,
0.010326262,
-0.019810101,
-0.001464368,
0.015268915,
-0.009246907,
0.02362733,
0.014294864,
0.024522405,
0.02275858,
0.013544581,
0.03145923,
0.02740507,
0.0074172704,
-0.012511296,
0.008213623,
-0.023469375,
0.00488342,
-0.0063444977,
-0.00073095,
-0.01695376,
0.027878933,
-0.034276083,
-0.037250888,
-0.026154598,
0.021534435,
0.009385117,
0.009042883,
-0.025180547,
-0.021810856,
0.014913518,
0.0060450425,
0.0011945294,
-0.015163613,
-0.012379668,
0.016927436,
-0.007594969,
-0.008174134,
-0.64108384,
-0.038619824,
-0.0017374973,
-0.0012661024,
0.0027872352,
0.016769482,
0.0079701105,
-0.00585089,
-0.013083881,
0.006555103,
-0.005926577,
-0.003652693,
-0.011142359,
-0.010234122,
-0.023969565,
-0.029879687,
-0.008884929,
-0.02454873,
0.023087652,
-0.021652902,
-0.033828545,
-0.008147809,
-0.024219658,
0.02689172,
-0.009095535,
0.016111339,
0.034881573,
-0.014887192,
-0.0016239675,
0.024509242,
-0.02031029,
0.014202723,
-0.016361432,
0.008601927,
0.05383609,
0.0006059028,
-0.0179673,
0.012425737,
-0.013189184,
0.056073774,
-0.016795807,
-0.0034749946,
0.024153844,
-0.010701403,
-0.018520141,
0.014834541,
-0.008713812,
-0.008878347,
0.0008654579,
0.004090358,
0.00912186,
-0.0019530391,
-0.032959796,
0.004090358,
0.022534812,
0.0022146509,
0.012136155,
-0.006798616,
0.0046102908,
0.009977446,
0.012879857,
0.02274542,
-0.0340918,
-0.0144396555,
-0.00023035001,
0.033881195,
-0.037566796,
-0.000852295,
0.006110857,
-0.00032763177,
0.010168307,
0.031143323,
-0.0037547052,
0.013373463,
0.005636994,
0.016466735,
0.0021488366,
0.0008070477,
-0.009806329,
0.0006865253,
0.017059064,
-0.015110961,
-0.019007167,
0.028668704,
0.016729992,
-0.0049393624,
-0.017493438,
0.009161349,
-0.018638607,
0.016848458,
0.010438146,
0.018270047,
-0.0031821209,
-0.048886854,
-0.014215887,
0.014847703,
0.011142359,
0.007384363,
-0.007687109,
-0.01732232,
-0.010767218,
-0.011083126,
0.009595724,
0.005143387,
0.024667196,
-0.007088199,
-0.031485558,
-0.001303123,
0.044174552,
-0.027852608,
0.021205364,
0.008286019,
-0.002357797,
0.009227163,
-0.00036691467,
-0.021560762,
0.01754609,
0.009161349,
-0.022205742,
-0.03195942,
0.019599495,
0.0040409975,
-0.010188052,
-0.012070341,
0.036882326,
0.025957156,
-0.014650261,
0.0030636552,
-0.007193502,
0.012695576,
-0.01800679,
-0.012425737,
0.015492683,
-0.029326847,
0.01299174,
0.009187675,
0.025391152,
-0.005577761,
-0.009424606,
-0.046675496,
-0.03361794,
-0.020520896,
0.0062062875,
-0.024443427,
-0.013162858,
-0.01253104,
-0.008470299,
-0.005126933,
0.016887946,
-0.0017210437,
-0.0012702158,
-0.008325508,
-0.008384741,
0.012682414,
0.019362563,
-0.0014076032,
0.009378537,
-0.010984405,
0.0076936902,
-0.0042055333,
-0.020441918,
0.040041413,
-0.01865177,
0.009464094,
-0.0014964524,
0.0017161076,
-0.0161245,
0.0039653108,
0.024956778,
-0.0432005,
-0.0040377066,
-0.000980633,
-0.015940221,
0.007305386,
-0.02270593,
0.0098853065,
-0.006397149,
-0.006485998,
-0.011807083,
-0.0048241876,
0.005739006,
-0.034012824,
0.010444728,
-0.009753678,
0.032775518,
0.020468244,
0.040278345,
0.0099050505,
0.010938335,
0.029537452,
0.0082531115,
0.007621295,
-0.019099306,
0.022903373,
0.011148941,
-0.052467152,
0.02727344,
-0.0023248899,
0.008536113,
0.023706308,
0.006071368,
-0.009536491,
0.016348269,
-0.005367155,
-0.001809893,
-0.020099685,
-0.032433283,
-0.01644041,
0.029010938,
-0.0046004187,
-0.002560176,
0.020968433,
-0.01524259,
-0.020784153,
0.007213246,
0.004472081,
-0.033854872,
-0.006420184,
-0.026352042,
0.0045576394,
-0.001860899,
-0.015611149,
0.0042581847,
-0.0009970865,
-0.004504988,
0.031722486,
-0.0030225213,
-0.0034486689,
-0.006890756,
-0.0147818895,
-0.0050315023,
0.0037415423,
0.0024351287,
-0.008549276,
0.01736181,
0.03403915,
-0.0041660443,
-0.018796561,
0.020968433,
0.00746334,
0.015124124,
0.018572792,
-0.009062627,
-0.0056764823,
-0.010944916,
-0.033591613,
0.032775518,
0.00787797,
-0.013873653,
0.00815439,
0.012044015,
0.016045524,
-0.0055645984,
-0.0024696812,
0.017493438,
-0.0046135816,
0.011135777,
0.010629008,
0.03606623,
0.01953368,
0.0028481134,
-0.004435883,
0.0069894777,
-0.03796168,
0.013544581,
0.014057932,
0.004577384,
-0.008740137,
-0.039672855,
0.008180716,
0.0036954724,
0.008220205,
0.007996436,
-0.026878556,
-0.00014581978,
0.017769858,
0.045938373,
-0.01809893,
0.0026292808,
0.013215509,
-0.0065057427,
-0.011208174,
0.010806707,
0.032696538,
-0.011826828,
-0.0030373295,
-0.02274542,
-0.007904296,
0.0005824565,
0.0073580374,
0.0024532275,
0.007397526,
-0.015110961,
-0.02252165,
-0.01441333,
0.0008876702,
0.016914273,
-0.011616222,
0.01962582,
-0.0069302446,
0.024772499,
-0.015071472,
-0.01091859,
-0.02510157,
0.039225318,
-0.003925822,
-0.009891888,
-0.0018822887,
-0.010161727,
-0.03864615,
-0.013505092,
-0.0024976523,
-0.007706853,
-0.016585201,
0.016071849,
0.004945944,
0.019072982,
-0.0012891374,
0.04978193,
-0.0042976732,
-0.0035539716,
-0.015045146,
-0.020336615,
-0.027694654,
0.030195596,
0.020928944,
0.014939844,
0.038988385,
-0.0017671137,
-0.0026704147,
-0.008049088,
-0.011642547,
0.008720393,
-0.029511128,
-0.0062260316,
0.0055810516,
0.00015291538,
-0.0041199746,
-0.0034717037,
0.011339802,
-0.011306895,
-0.010313099,
-0.026523158,
0.017585577,
0.0032956505,
-0.0047912803,
0.034434035,
0.0468861,
0.023245607,
0.01644041,
0.012498134,
0.010418402,
0.0012537622,
-0.0021718715,
-0.01234018,
0.02454873,
0.0009863917,
0.010346007,
-0.0037448332,
-0.025351664,
0.019467866,
0.0055711796,
0.010332843,
0.002178453,
0.013610395,
0.02648367,
0.002574984,
-0.02215309,
-0.014571284,
0.004945944,
-0.0070684548,
0.008463718,
-0.018599119,
-0.012629762,
0.018678095,
-0.01754609,
-0.007943785,
-0.009845817,
-0.004876839,
0.017164366,
0.017927812,
-0.01027361,
-0.011714944,
-0.024232822,
-0.00007398966,
-0.010141982,
0.01653255,
-0.0036494024,
0.004228568,
-0.008891511,
-0.009674701,
-0.004024544,
-0.016611526,
-0.009898469,
0.019796938,
-0.02058671,
-0.041936867,
0.0021768077,
0.00024433556,
0.025575433,
0.024403939,
-0.017059064,
-0.008569021,
0.018941352,
-0.0042022425,
-0.028036887,
-0.00014818499,
-0.020994758,
0.0020303708,
0.011550408,
0.001003668,
-0.009964284,
-0.021639738,
0.004577384,
0.013412952,
-0.003527646,
-0.0040377066,
-0.005831146,
-0.030880064,
-0.0016214995,
0.007226409,
0.016414084,
-0.009569398,
-0.022600627,
-0.005367155,
-0.03311775,
-0.014637098,
-0.014558121,
-0.00912186,
-0.010161727,
-0.0031064344,
-0.0061371825,
-0.0074041076,
-0.014057932,
-0.003233127,
-0.014571284,
-0.0009115279,
-0.0032759062,
0.0056402846,
-0.014150072,
0.0063905674,
0.0028152063,
0.0079701105,
0.010655333,
0.0046991403,
-0.022179415,
0.034144454,
0.007061873,
-0.0137946755,
0.008483462,
0.000106845386,
0.0007490489,
-0.02639153,
-0.018296372,
-0.021758204,
0.013333975,
-0.00391595,
-0.021205364,
-0.01616399,
-0.011201592,
-0.0003720564,
0.0067920345,
-0.002869503,
-0.021073736,
-0.0033795638,
0.008588765,
-0.0021981972,
0.0055810516,
0.010049842,
-0.035855625,
-0.0033729824,
0.014953007,
0.0085953465,
0.017414462,
-0.0022969188,
0.0033960172,
-0.0043075453,
-0.0076805274,
-0.029089916,
-0.05125617,
0.002892538,
-0.009345629,
0.041463003,
0.029089916,
0.037856378,
0.007535736,
0.034249756,
0.010023517,
0.007562062,
-0.009872143,
-0.010313099,
0.0144396555,
-0.025759714,
0.014150072,
0.0023232445,
-0.0012266138,
0.02777363,
-0.013899978,
0.02445659,
0.028879311,
-0.007989855,
-0.018822886,
-0.000042830707,
-0.03472362,
-0.016703667,
0.02261379,
-0.022942862,
-0.0020846676,
-0.02985336,
0.005143387,
0.002367669,
0.022205742,
-0.012221714,
-0.0030570738,
0.015808592,
-0.029563779,
0.022074113,
-0.032722864,
0.0001426319,
-0.017059064,
-0.0058245645,
-0.004245022,
-0.023614166,
0.026312552,
0.00944435,
0.012300691,
0.0051565496,
0.0014610772,
-0.012300691,
0.010655333,
-0.015413706,
-0.024061704,
-0.005933158,
-0.015834918,
-0.013143114,
-0.007562062,
-0.019770613,
-0.0066340803,
-0.018941352,
-0.001080177,
-0.016756319,
0.016269293,
-0.020415593,
-0.011668874,
0.040278345,
0.001121311,
0.015492683,
-0.029906014,
0.03380222,
0.022008298,
-0.007818738,
0.001563912,
-0.014505469,
-0.020323453,
-0.011761013,
0.052493475,
0.029563779,
0.0010011998,
-0.017796183,
-0.008740137,
0.013037811,
-0.0188887,
-0.016111339,
0.01736181,
0.02178453,
-0.009648375,
-0.027194465,
0.0052388175,
-0.025733387,
0.015255752,
-0.011807083,
0.0016823778,
0.012215132,
-0.012221714,
-0.012419157,
0.021850344,
-0.0033400753,
0.026009807,
0.0052618524,
-0.019151958,
-0.03896206,
-0.012399412,
-0.02031029,
-0.00022479694,
0.0056995177,
-0.002454873,
-0.0075883875,
0.0074172704,
0.03877778,
0.0015416997,
-0.006107566,
-0.009865562,
0.004702431,
0.043911293,
-0.005222364,
-0.017888324,
0.016229805,
-0.009404862,
0.0065156147,
-0.01865177,
0.00064292335,
0.007720016,
-0.039409596,
-0.010859358,
0.022508487,
0.028379122,
-0.0027230661,
-0.012287528,
-0.026167762,
-0.008779626,
-0.032249,
-0.006038461,
0.0024647452,
-0.035987254,
-0.01824372,
-0.0034980294,
0.015045146,
0.022034625,
0.0068973377,
0.021863507,
-0.020060195,
0.013386627,
-0.014071095,
0.037698425,
0.029748058,
0.012392831,
-0.010938335,
0.006670278,
-0.0015194874,
-0.03546074,
0.009793166,
-0.024390776,
-0.041120768,
0.0013006548,
-0.0012307272,
0.022692766,
0.0024433555,
-0.0042351494,
-0.007167176,
0.0023824773,
0.02468036,
-0.0023002094,
-0.011168685,
-0.00011908273,
-0.012511296,
-0.010095912,
0.0029583522,
-0.011484593,
0.000035092384,
-0.0058146925,
-0.021350155,
-0.0013886815,
-0.025641248,
0.010220959,
-0.013623558,
0.008687486,
-0.011333221,
-0.019875916,
-0.004748501,
-0.00013862134,
-0.026536321,
0.018704422,
0.0031854117,
-0.020876292,
-0.017677719,
0.0007975869,
0.0147424005,
0.020902619,
0.0007219005,
0.0028546948,
0.002408803,
-0.025075244,
-0.013715697,
0.0036559838,
-0.02049457,
0.053862415,
0.020283964,
0.003560553,
-0.021981973,
-0.007608132,
-0.057232104,
-0.05839044,
0.004551058,
0.005534982,
0.003675728,
0.0069894777,
-0.014321189,
0.0046958495,
-0.0069565703,
0.0019398761,
-0.004485244,
-0.02003387,
0.027694654,
0.0011846572,
0.0076542017,
0.011445105,
-0.017796183,
-0.0024301927,
0.023337748,
0.00001003925,
-0.01966531,
0.017295996,
-0.009457514,
0.033565287,
0.0044391737,
0.023021838,
0.0122019695,
0.030169271,
0.03293347,
-0.02362733,
0.008378159,
0.011945293,
-0.0052717244,
-0.010424984,
0.0074172704,
-0.009839236,
0.020152336,
0.0065353587,
0.015282078,
-0.025641248,
-0.0043733595,
-0.021007922,
0.024469752,
0.0048439316,
-0.0018345733,
0.022561138,
0.008193879,
-0.0030932715,
-0.013610395,
-0.007206665,
-0.034381386,
0.0028793751,
-0.0069434075,
-0.020981595,
-0.013031229,
-0.0012702158,
-0.0147424005,
-0.03206472,
0.017335484,
-0.0033400753,
0.0007511056,
0.0022409766,
0.038330242,
0.0040969397,
-0.0019777194,
-0.017756695,
-0.00048825977,
-0.020073358,
-0.03145923,
-0.003596751,
-0.01298516,
-0.015308403,
-0.00041339602,
-0.011504338,
-0.00866116,
0.005692936,
0.012550785,
-0.0077529233,
-0.011293732,
0.01962582,
0.19544211,
-0.0079306215,
-0.0012480034,
0.009227163,
0.02727344,
-0.015229426,
-0.0036230767,
0.002445001,
-0.0048505133,
0.011412198,
0.0014224113,
0.0045148605,
0.0031525046,
-0.0065485216,
0.03638214,
-0.029642755,
-0.0063642417,
0.0079306215,
-0.014373841,
0.0013245125,
0.007766086,
-0.029774385,
0.024798824,
-0.003938985,
0.04177891,
-0.008081995,
-0.021981973,
0.0004181264,
0.023192955,
0.010148563,
-0.018585956,
0.021613413,
-0.015150449,
0.0102275405,
0.0026144728,
-0.0071013616,
-0.0071079433,
0.003256162,
0.0076673646,
0.0049294904,
0.015703289,
-0.009668119,
-0.014650261,
0.00092798145,
-0.0022919825,
0.0137946755,
0.001236486,
-0.017230181,
-0.006235904,
-0.007904296,
-0.038145963,
0.02077099,
0.02325877,
0.01492668,
-0.009589142,
0.009477258,
0.023930077,
0.024009053,
-0.002114284,
0.027826281,
-0.014294864,
0.0035901696,
-0.0056304126,
0.017611904,
-0.022600627,
0.018164745,
-0.020836804,
-0.008332089,
0.015400544,
-0.015361055,
-0.0027066127,
-0.011629385,
-0.019151958,
0.0154268695,
-0.014229049,
-0.029037265,
0.018941352,
0.0012907827,
0.008740137,
0.022205742,
0.019151958,
0.010642171,
-0.029142568,
0.00058656983,
-0.0010727729,
-0.03933062,
0.027010184,
0.014650261,
-0.030458853,
-0.017861998,
0.015321567,
0.0014289927,
-0.0079701105,
-0.012715321,
0.02528585,
-0.004001509,
-0.00015774863,
-0.0020468244,
-0.013807838,
0.0063214623,
-0.025220037,
0.050729655,
0.02777363,
0.00833867,
0.001628081,
0.025904505,
-0.012563948,
0.008720393,
-0.012853531,
-0.006512324,
0.017388135,
-0.010497379,
0.02340356,
-0.004712303,
-0.018678095,
0.038672477,
0.01911247,
-0.01911247,
0.03251226,
-0.014544958,
-0.011300313,
-0.0073909448,
0.0048669665,
0.02790526,
-0.022258393,
0.007055292,
-0.02919522,
0.003289069,
0.0033433659,
-0.011649129,
-0.007515992,
-0.0008736847,
0.004899874,
0.01865177,
0.019823264,
-0.025088407,
0.019007167,
-0.016585201,
-0.024061704,
0.026273064,
-0.0034519595,
0.0054362603,
0.0028546948,
0.0134919295,
0.014071095,
0.004504988,
0.017388135,
0.032959796,
-0.0057422966,
-0.030695785,
-0.00912186,
-0.02067885,
-0.012129573,
-0.011392454,
0.013860489,
-0.010128819,
-0.017190693,
-0.012906183,
0.035723995,
0.00097076077,
-0.027694654,
0.01630878,
-0.009516746,
-0.0156638,
-0.001218387,
0.0023199536,
-0.16427247,
0.002519042,
0.033328354,
-0.03693498,
0.041673608,
0.02519371,
-0.021929322,
0.010793543,
-0.02727344,
0.0060647866,
0.04620163,
0.016637852,
-0.039830808,
-0.028879311,
0.0121624805,
0.012169062,
0.022179415,
0.029405825,
0.0150846355,
0.013649884,
0.029484801,
-0.009918214,
0.022311045,
0.017532926,
0.029326847,
0.0051335148,
-0.0020385976,
0.0005631235,
0.012465226,
-0.024759335,
0.0018247012,
0.0014544958,
0.032249,
0.020297127,
0.0015458132,
0.0022327497,
-0.009332466,
-0.0036362396,
-0.0082926005,
0.008364996,
0.0211922,
0.0038698802,
-0.0038468451,
0.021481784,
-0.02058671,
0.01920461,
-0.013728861,
0.006104275,
0.022468999,
-0.029142568,
0.019823264,
0.007167176,
-0.0008843795,
0.024996268,
0.021113224,
0.003850136,
0.012458645,
0.01588757,
0.016071849,
-0.023298258,
0.013834164,
0.0040278346,
0.016966924,
-0.00062811514,
-0.010194633,
-0.026444182,
0.007897715,
0.022837559,
-0.019783776,
0.014663423,
-0.003481576,
-0.040225692,
0.010800125,
-0.01962582,
0.018401675,
-0.0034256338,
0.0014610772,
-0.015953384,
-0.024338124,
0.0037514146,
-0.0275367,
0.02547013,
-0.01492668,
-0.014702912,
-0.011004149,
0.015005658,
0.0029961956,
0.020165497,
0.012781135,
-0.0014166526,
0.025259525,
-0.012787716,
-0.006222741,
-0.010161727,
0.042437054,
0.01953368,
-0.009174512,
-0.020376105,
-0.019783776,
-0.0018625443,
0.011188429,
-0.013715697,
-0.009773422,
0.0144396555,
0.009661538,
0.0023939947,
-0.021863507,
0.00681836,
0.07107943,
-0.00087121665,
-0.012827205,
-0.013176021,
0.006640662,
0.011359546,
-0.006331335,
0.026944371,
0.004577384,
0.00852295,
0.006038461,
-0.03206472,
0.0496503,
0.009858981,
-0.010859358,
0.03722456,
0.011504338,
-0.03693498,
-0.15342627,
-0.0111752665,
0.0022047786,
0.015637476,
0.019796938,
0.01911247,
-0.009773422,
0.006383986,
-0.017664555,
0.027431395,
-0.035987254,
-0.019454705,
0.013393207,
-0.029879687,
-0.0042055333,
-0.00075069425,
0.0070026405,
-0.009602305,
-0.02685223,
0.028879311,
-0.0034256338,
0.000019050152,
-0.01865177,
0.0051236423,
0.009437769,
0.030564155,
-0.046622843,
0.022692766,
0.0041528814,
0.02906359,
0.010536868,
-0.0021636446,
0.018349024,
-0.0098853065,
-0.01331423,
-0.018928189,
0.009115279,
-0.019230936,
0.028352795,
-0.009589142,
0.0022590754,
0.0077397604,
0.021850344,
-0.018638607,
0.0020287256,
0.0046234536,
-0.03164351,
0.0020270802,
-0.0063708234,
-0.019994382,
-0.04491167,
-0.016019197,
-0.02224523,
-0.0012118056,
0.016703667,
-0.018704422,
0.008187298,
0.01091859,
-0.0057488782,
0.009924795,
-0.006844686,
-0.001878998,
-0.022376858,
0.00714085,
0.017072227,
-0.016664177,
-0.030090293,
-0.022442672,
0.026141435,
0.005590924,
0.0026046005,
-0.0027296476,
-0.0040475787,
0.0031903477,
-0.011129197,
0.010313099,
-0.0040607415,
-0.01662469,
-0.01824372,
-0.00027621436,
0.0025865017,
-0.021547599,
0.013505092,
0.004416139,
0.0116952,
0.005061119,
0.00746334,
0.016137663,
-0.0009353856,
-0.0060647866,
-0.0030225213,
0.034460362,
0.026470507,
-0.0052486896,
0.0046070004,
0.0031870569,
0.0115569895,
-0.0025519491,
0.022376858,
0.016914273,
-0.0007284819,
-0.008312345,
-0.041620955,
-0.003215028,
-0.013742024,
0.00801618,
0.022442672,
-0.022455836,
-0.0012735066,
-0.01984959,
-0.0034256338,
0.018151581,
-0.005913414,
0.01298516,
-0.010484217,
-0.0018674805,
-0.040883835,
-0.023508864,
0.010352587,
-0.015874406,
0.016058687,
0.030406201,
-0.00044218975,
-0.025509618,
0.008687486,
-0.026431018,
-0.013215509,
0.00039138936,
-0.020283964,
0.009839236,
-0.006028589,
-0.014716075,
0.017164366,
-0.04399027,
-0.014202723,
0.011721525,
-0.023232443,
-0.009200837,
0.01266267,
0.033459984,
0.020994758,
0.02169239,
-0.02924787,
-0.0413577,
0.014229049,
0.001883934,
-0.014689749,
0.008529532,
-0.033012446,
-0.0108725205,
-0.015071472,
-0.001883934,
0.061180964,
0.0102275405,
0.0063444977,
-0.026444182,
-0.0012134509,
-0.01344586,
0.0010859357,
-0.0027740723,
0.00681836,
-0.021429133,
-0.0021751623,
0.011655711,
0.017993627,
-0.0050907354,
0.0002317897,
-0.01640092,
-0.021639738,
0.010010353,
-0.006982896,
-0.012978578,
-0.01597971,
-0.014623935,
-0.0014915164,
-0.0045378953,
0.019678472,
-0.0061404733,
-0.0036625653,
0.0089375805,
-0.019599495,
0.026457345,
0.010490797,
0.011352965,
-0.0046826866,
0.005107189,
0.028852984,
0.0035802973,
-0.013557743,
0.014057932,
0.00071326236,
0.0013426115,
-0.0054099346,
0.002173517,
0.017927812,
-0.003085045,
0.021824019,
0.012833786,
-0.0066307895,
0.022311045,
-0.011004149,
0.03522381,
0.006002263,
0.010036679,
0.013182602,
-0.014531795,
-0.0037547052,
0.015229426,
-0.016466735,
-0.020468244,
-0.016006036,
-0.0009452577,
-0.006558394,
-0.0050775725,
0.014242212,
-0.0055942144,
-0.028931962,
0.010424984,
-0.0043141264,
0.010352587,
-0.0061503453,
0.025575433,
-0.002168581,
-0.013886815,
-0.014031607,
-0.0062128687,
0.0049722698,
0.0039916364,
0.031538207,
0.0013360301,
0.039093688,
-0.010661915,
0.004251603,
-0.012971996,
-0.007397526,
-0.016203478,
-0.013478766,
-0.013195765,
-0.0011303604,
0.026983859,
-0.014044769,
0.07502829,
0.024496078,
-0.029669082,
0.021073736,
-0.019244099,
0.024746172,
-0.0064563816,
0.018454326,
-0.038172286,
-0.032301653,
0.017954139,
-0.016427247,
0.02113955,
-0.025614921,
0.004574093,
0.027431395,
-0.010095912,
0.03238063,
0.015071472,
0.002762555,
0.020994758,
0.002081377,
-0.001625613,
0.0058146925,
-0.032222677,
-0.011037056,
0.02113955,
0.00025914377,
-0.009648375,
-0.009174512,
0.003422343,
0.0017243344,
-0.03711926,
0.015571661,
-0.014571284,
0.006653825,
-0.013584069,
-0.00626552,
0.013899978,
0.025180547,
-0.009385117,
0.027352419,
-0.024338124,
-0.022732256,
-0.039988764,
-0.013913141,
-0.0019958182,
-0.0077595045,
-0.01266267
] |
This study investigated interobserver (two observers) and intrasubject (two measurements) reproducibility of QT dispersion from abnormal electrocardiograms in patients with previous myocardial infarction, and compared a user-interactive with an automatic measurement system. Standard 12-lead electrocardiograms, recorded at 25 mm.s-1, were randomly chosen from 70 patients following myocardial infarction. These were scanned into a personal computer, and specially designed software skeletonized and joined each image. The images were then available for user-interactive (mouse and computer screen), or automatic measurements using a specially designed algorithm.
|
[
-0.035923947,
0.014222678,
0.014890409,
-0.022529256,
0.008627089,
0.01434287,
-0.0013104228,
-0.0144630615,
-0.037499793,
-0.0058793747,
-0.010456673,
0.034267973,
0.0033019315,
-0.0019464369,
-0.02383801,
0.0001003162,
0.013875457,
0.025721012,
0.005555525,
-0.022609383,
-0.015010601,
0.047756147,
-0.002969735,
0.011137759,
-0.023450725,
0.019751493,
-0.0003036091,
-0.014129195,
-0.0009298159,
-0.0038561486,
-0.0032251424,
-0.0038561486,
-0.0252536,
-0.019177245,
-0.04078503,
-0.024652641,
-0.008333287,
-0.008179709,
0.01163188,
-0.0015466327,
-0.0059094224,
-0.009935843,
-0.0040397746,
0.010169549,
0.0076121376,
0.0018412692,
-0.009688782,
-0.026709255,
-0.011758749,
0.03010133,
-0.00055839034,
-0.01824242,
0.009127888,
0.015491367,
0.011211209,
-0.011985778,
0.00457396,
0.0032101185,
0.0049812756,
-0.025173472,
-0.009662073,
-0.009334885,
-0.027176665,
0.012312966,
-0.015104083,
-0.007885907,
0.00135466,
0.006670636,
0.012139356,
-0.0126134455,
0.026602417,
0.021594431,
-0.020339098,
0.021727977,
0.02398491,
-0.022369001,
-0.014850345,
-0.012633477,
-0.0016467924,
0.0054420107,
0.0040030493,
-0.028899413,
-0.011351433,
0.019377563,
-0.0103899,
0.011738718,
-0.020192197,
0.010823925,
-0.021207148,
0.004767602,
0.015224275,
0.016332708,
0.009675427,
0.00065896736,
-0.012172743,
-0.00085386145,
-0.00753201,
0.03870171,
-0.008627089,
-0.0130007295,
-0.0036291198,
-0.005174918,
-0.012299611,
-0.015664978,
-0.0113714645,
-0.01245319,
0.00081421493,
-0.0045338958,
0.005448688,
-0.0058326335,
0.0039129057,
0.034855578,
-0.0021033539,
-0.00019437242,
0.015264339,
0.011611848,
-0.0001595252,
-0.006620556,
0.0021066924,
-0.0070111793,
0.024746124,
-0.013728556,
0.024919733,
-0.029620564,
-0.00044696266,
0.007111339,
-0.028151553,
0.001128466,
0.020833218,
-0.005575557,
0.011064309,
0.009328207,
0.0104967365,
0.0104299635,
-0.020472644,
-0.002629192,
0.005271739,
0.015464658,
-0.011364788,
-0.020085359,
0.0005487917,
-0.00014930055,
0.0016968723,
-0.031570338,
-0.0026408774,
0.03616433,
0.007304981,
0.012019164,
0.024639286,
-0.010904053,
-0.008279868,
-0.013888812,
0.00593947,
-0.003492235,
0.0018613011,
0.0057157804,
0.0025073313,
0.01506402,
-0.039903626,
-0.010062711,
-0.019965168,
0.003695893,
-0.019885039,
-0.0056456686,
0.009334885,
0.014796927,
-0.0013830386,
-0.024105102,
0.022048488,
-0.0125466725,
-0.021193793,
0.032291487,
-0.011999132,
0.011224564,
0.021754688,
-0.010917407,
-0.00035410628,
0.0016935336,
-0.029032959,
-0.02970069,
-0.023597626,
0.037793595,
0.009194661,
0.025493983,
-0.006166499,
0.005555525,
0.01642619,
0.010570187,
0.011758749,
-0.004023081,
0.0069310516,
-0.009808973,
-0.024559159,
-0.01786849,
-0.6538425,
0.0030465242,
0.010329804,
-0.021914942,
0.0037593276,
0.028365228,
0.007972713,
0.013534915,
0.0050447104,
0.029193215,
-0.0044170427,
0.025547402,
0.0056757163,
-0.012573381,
-0.034161136,
-0.027884461,
-0.012166065,
-0.0038194233,
0.0013179347,
0.007298304,
-0.023610981,
0.013127598,
-0.029246634,
0.022088554,
0.011464947,
0.0044203815,
0.0070045018,
-0.021460885,
-0.021661205,
0.024372194,
-0.017320951,
0.010884021,
0.0023854703,
0.0049745985,
0.044738002,
-0.0415596,
-0.013047471,
0.007304981,
0.020592835,
0.034962412,
-0.015117438,
-0.0075921053,
0.033840626,
-0.014449706,
-0.019257372,
0.0012603429,
-0.021808106,
-0.003589056,
-0.0070111793,
-0.0061998856,
-0.006300045,
-0.015998844,
-0.012867183,
0.016840184,
0.031543627,
0.003956308,
0.015972134,
0.022248808,
0.012646832,
0.017361015,
0.0058292947,
0.009181306,
-0.0030097992,
-0.012519963,
-0.009208015,
0.0073984633,
0.008072872,
-0.008353319,
0.01148498,
-0.028124845,
0.015010601,
0.0015090728,
-0.0060897097,
-0.007925971,
0.01697373,
0.021727977,
0.008480188,
-0.0076188147,
-0.002495646,
-0.0066940067,
-0.01252664,
0.009268112,
-0.019150535,
0.0006915193,
0.016386127,
0.02127392,
-0.00912121,
0.0056523457,
0.007091307,
0.0038294394,
-0.008493543,
0.0032702142,
0.017788364,
-0.01991175,
-0.016199162,
0.028525483,
-0.01642619,
0.008173032,
0.01145827,
-0.017775008,
-0.0051482087,
0.008266514,
-0.0026725947,
0.0024973152,
-0.011451593,
0.019083763,
-0.032425035,
-0.0001238433,
0.025146762,
-0.011104372,
-0.0064068823,
-0.0067674574,
-0.00074243377,
0.0069978246,
0.005328496,
-0.040571358,
0.002440558,
0.008740603,
-0.012266225,
-0.020138778,
0.010249676,
-0.017067213,
0.030769061,
-0.00420003,
-0.016346063,
0.010777184,
0.005308464,
0.013568301,
0.0014748516,
-0.03394746,
-0.017320951,
0.02560082,
0.00867383,
-0.011785459,
0.009622009,
0.00760546,
0.029406888,
-0.01036319,
-0.021006828,
-0.02363769,
-0.017841782,
-0.009328207,
0.013728556,
-0.005819279,
0.0070045018,
-0.03795385,
-0.0049846144,
0.005612282,
0.017841782,
0.0006285021,
-0.017588044,
-0.023530852,
-0.008660476,
0.021140374,
-0.0024973152,
-0.004190014,
-0.011712008,
-0.014877055,
-0.012012487,
-0.012980698,
0.019991877,
0.020793155,
-0.03149021,
-0.018015392,
0.00076163106,
-0.03162376,
-0.0063935276,
-0.01235303,
-0.020432578,
-0.040224135,
-0.002130063,
0.008473511,
-0.004961244,
0.00058092625,
-0.005565541,
0.031944267,
-0.0046073464,
-0.018335903,
0.01558485,
-0.0354966,
0.03295922,
0.0046574264,
-0.01297402,
-0.013287853,
0.024973152,
0.008814054,
0.0033369875,
-0.020753091,
-0.0049645826,
0.027430404,
-0.000343673,
0.01928408,
-0.0097422,
0.0042901738,
-0.008660476,
0.010283063,
-0.0010324796,
-0.0033253022,
0.011725362,
0.043082025,
0.041880112,
0.01647961,
0.025240244,
0.013160985,
0.0072114985,
-0.020833218,
0.029887656,
-0.027617369,
0.04081174,
0.017027149,
0.011798813,
0.004450429,
0.018709833,
-0.020806508,
-0.019617947,
0.017320951,
0.01270025,
0.026362034,
0.008827409,
0.011398174,
-0.016332708,
0.009054437,
0.023196988,
0.022369001,
0.0048610843,
-0.0037493114,
0.01700044,
0.010449995,
0.015277693,
-0.0047909725,
-0.008800699,
-0.0064502847,
0.014236032,
0.01971143,
0.018108875,
0.025854558,
0.002821165,
0.015611559,
0.019724784,
0.0070245336,
0.01063696,
0.0062866905,
0.0021317324,
-0.01928408,
0.014155905,
-0.01812223,
0.016840184,
0.018870087,
0.0044237203,
0.0053518666,
0.0013988971,
-0.00380273,
-0.038541455,
0.011097695,
-0.00760546,
-0.00060387957,
0.008920891,
0.0018880104,
0.028391937,
0.027724206,
0.018082164,
0.00096403714,
0.0024422274,
0.009481785,
0.0027009733,
-0.0019748155,
0.0021450869,
0.0021934975,
-0.005669039,
-0.02577443,
0.0027644078,
-0.014022359,
-0.00033386567,
-0.023944845,
0.024973152,
0.0056657004,
0.020045295,
-0.007892584,
0.014957182,
0.020699672,
-0.030929316,
-0.04019743,
0.015424594,
0.012012487,
0.0033820593,
0.00081588427,
-0.006877633,
-0.007284949,
-0.018856734,
0.031810723,
0.011237918,
0.0007582924,
0.020138778,
-0.01858964,
-0.007865875,
-0.018976925,
0.032692127,
-0.0081262905,
-0.008119613,
0.0067774733,
0.014022359,
0.0101094525,
-0.005231675,
-0.03584382,
0.029139796,
0.013040793,
0.0005905249,
-0.006106403,
-0.001573342,
0.022929894,
-0.0045405733,
-0.011685299,
-0.018936861,
0.004687474,
-0.02132734,
0.010423287,
-0.020806508,
-0.024572514,
0.028498774,
-0.014276097,
-0.020966765,
-0.025854558,
-0.013675138,
-0.027537242,
0.024425613,
0.034401517,
-0.004767602,
0.014449706,
-0.0054153013,
0.0063568023,
-0.007892584,
-0.022555966,
0.0073116585,
0.02398491,
-0.024118457,
-0.0054920902,
0.010456673,
0.0021534336,
0.000786671,
0.022529256,
0.01829584,
-0.0069711152,
-0.0016709977,
-0.01558485,
-0.008660476,
0.0068976646,
0.0360842,
0.017881846,
0.0065604607,
-0.040598065,
0.028819285,
0.012306289,
0.022355646,
-0.017507916,
-0.0019414289,
0.03904893,
-0.008967632,
0.0042167236,
-0.012119324,
0.0059561636,
0.035977364,
0.006663959,
-0.000336787,
0.008920891,
0.015357821,
0.038140815,
-0.0035122668,
0.0055354927,
0.021380758,
0.0046574264,
0.005328496,
0.021420822,
-0.0119590685,
-0.019350855,
0.02433213,
-0.006069678,
-0.013635074,
-0.009214693,
-0.00469749,
-0.019898394,
-0.024412258,
-0.020352451,
-0.014543189,
0.0019197277,
-0.0054687196,
-0.018282484,
0.012553349,
0.0050947904,
-0.013728556,
-0.012092615,
-0.022929894,
-0.031383373,
0.0013905505,
0.010403254,
-0.012146033,
-0.029540434,
-0.029406888,
0.0075119776,
-0.0056957486,
0.0050447104,
0.023744527,
0.0065504448,
0.0070378883,
0.0015074036,
-0.018976925,
0.014022359,
0.003792714,
-0.012593414,
-0.011211209,
0.01627929,
-0.0023971556,
-0.008653798,
0.025787786,
0.02719002,
0.036698516,
-0.01899028,
0.020045295,
-0.009268112,
0.013134276,
0.012633477,
0.0070645977,
0.022876477,
0.00073492184,
-0.015504722,
0.00059469824,
-0.029941075,
0.000579257,
-0.014503125,
0.011812167,
-0.0030097992,
-0.027831042,
0.0026141682,
0.017187405,
-0.007585428,
-0.018549576,
-0.015491367,
-0.0053518666,
0.003365366,
0.051442023,
0.011244596,
0.009061115,
0.021834815,
0.0025690964,
0.008820731,
-0.006563799,
0.011625202,
0.020085359,
-0.021500949,
-0.003548992,
0.031650465,
-0.018629706,
-0.024679352,
-0.02967398,
0.00034868097,
0.02182146,
0.017107278,
-0.008206419,
-0.013862103,
-0.026402097,
0.00033157034,
0.0032251424,
0.010036002,
-0.0051782564,
0.00010934101,
0.0000011607049,
0.015264339,
-0.0097422,
-0.0017561334,
0.02214197,
-0.023624334,
0.0014831983,
0.009374948,
-0.037473083,
0.018002037,
-0.010082743,
0.010283063,
-0.0037092476,
-0.00743185,
-0.019444337,
-0.027590659,
-0.022328936,
-0.009441721,
0.03402759,
0.036618385,
0.042040367,
0.019057052,
-0.0044871545,
-0.0018913491,
-0.005856004,
0.004320222,
-0.0014164251,
-0.0074251727,
-0.002749384,
0.03621775,
-0.0005800916,
-0.0051582246,
0.001804544,
-0.025240244,
0.007104662,
0.032772254,
-0.009702137,
0.006056323,
0.016733348,
-0.0427081,
0.022996668,
0.010670347,
0.0055488474,
0.0029146473,
-0.040304266,
-0.011818845,
0.048984773,
0.0023070117,
0.0013504867,
0.0070245336,
0.019871686,
-0.015104083,
0.019110471,
-0.0016793443,
0.026068231,
0.0046140235,
-0.014943828,
-0.02433213,
0.00020699672,
0.024946444,
0.025387146,
0.019844975,
-0.008840763,
0.0068308916,
-0.025680948,
-0.007178112,
-0.013588333,
0.017734945,
-0.010356513,
-0.0018679785,
0.008620412,
-0.020753091,
-0.0115383975,
0.0035256215,
0.0013312894,
0.029032959,
-0.002043258,
-0.00044904934,
-0.015224275,
0.0020833218,
0.020619543,
0.010543478,
0.038621582,
-0.004383656,
0.013514883,
-0.0006944406,
-0.013715202,
0.0070178565,
-0.013715202,
0.014449706,
0.004056468,
0.025186827,
0.037019026,
-0.03581711,
-0.013875457,
0.021220502,
0.001794528,
-0.03408101,
-0.031970978,
0.010610251,
0.009708813,
-0.0066672973,
-0.034802157,
0.008132968,
-0.03189085,
0.029246634,
-0.015785169,
-0.01448977,
0.012326321,
0.008707217,
-0.023610981,
0.035576727,
-0.023651045,
0.031196408,
-0.00022869799,
-0.017975328,
-0.014409643,
0.000053235926,
-0.028792575,
0.0061531444,
0.0065337513,
0.016159099,
-0.0114716245,
0.0029897671,
0.009535204,
0.024986507,
-0.013741911,
-0.0252536,
-0.015304402,
0.037392955,
-0.00268428,
-0.008313255,
0.020138778,
-0.010950794,
0.007966035,
0.0008572001,
-0.01985833,
-0.026682544,
-0.023143569,
0.006517058,
0.012459867,
0.015491367,
0.00912121,
-0.0010291409,
-0.012860506,
-0.019698074,
-0.010283063,
-0.026962992,
0.015117438,
-0.05913429,
-0.020859927,
-0.006002905,
0.017147342,
0.019844975,
0.014970537,
0.018402675,
0.009682105,
0.013054148,
-0.0056957486,
0.023597626,
0.020699672,
0.0062733362,
-0.028204972,
-0.0029747433,
-0.01985833,
0.008994341,
0.008887504,
-0.009915811,
-0.0070245336,
-0.034267973,
-0.01772159,
0.025547402,
-0.0115717845,
-0.004640733,
0.014195968,
-0.0007633004,
0.007498623,
-0.004694151,
-0.015277693,
0.0010383222,
-0.006390189,
0.0052149817,
0.015478013,
-0.021006828,
0.003522283,
-0.021207148,
-0.008533606,
0.028044717,
-0.029326761,
-0.0020849912,
-0.0030064604,
0.01163188,
-0.0354966,
-0.010603574,
-0.022355646,
-0.00024685194,
-0.021968361,
0.012139356,
-0.01359501,
-0.0010099437,
0.0026041523,
0.004757586,
-0.006747425,
0.016639866,
-0.012386416,
-0.00041086346,
-0.008820731,
0.0068843104,
-0.014770217,
-0.020592835,
-0.010750474,
0.025654238,
0.0354966,
-0.024919733,
-0.017614754,
0.0006255808,
-0.056463365,
-0.014756863,
-0.018282484,
0.002043258,
0.011551753,
0.012499931,
-0.003004791,
0.029941075,
-0.009268112,
0.029540434,
-0.03368037,
-0.016078971,
0.015531431,
-0.0033386569,
0.0066439267,
-0.010316449,
-0.03832778,
0.0019414289,
-0.01046335,
0.01878996,
0.010810571,
0.017013796,
-0.0047275377,
-0.0054520266,
0.028151553,
0.014369579,
0.0038795192,
0.008954277,
-0.00790594,
-0.027884461,
0.01581188,
-0.0021417483,
0.009014374,
-0.010623606,
-0.011424883,
0.029540434,
-0.0016785096,
-0.008480188,
-0.038033977,
-0.029567145,
0.015317758,
-0.009762232,
0.0062866905,
0.010843957,
-0.004947889,
0.035763692,
-0.019965168,
0.012166065,
-0.001573342,
-0.005088113,
0.011164468,
0.0013204387,
-0.0053351736,
-0.025160117,
-0.013281177,
-0.018375967,
0.013154307,
-0.0075653964,
-0.0012762016,
-0.0027477145,
-0.02868574,
-0.0360842,
0.013408045,
0.027831042,
0.0031366681,
-0.017013796,
-0.0007407645,
-0.01101089,
0.0020516047,
-0.0091011785,
0.00939498,
-0.034134425,
0.0035389762,
0.0030064604,
-0.017401079,
0.0060195983,
-0.008693862,
-0.010449995,
0.014249387,
0.020312387,
0.1777768,
-0.0051515475,
-0.008794022,
0.034401517,
-0.024692705,
-0.0038695033,
0.020552771,
0.0066272337,
-0.009615332,
0.03688548,
0.018402675,
0.0017678187,
-0.014543189,
0.0019364209,
0.015304402,
-0.009575267,
-0.010216289,
-0.017494561,
0.0149171185,
0.014449706,
0.00017621848,
-0.019951813,
-0.005869359,
-0.005932793,
0.019751493,
0.0017110616,
-0.0004941212,
0.021260567,
0.022622738,
0.02358427,
-0.011451593,
-0.004433736,
0.013120921,
0.011104372,
-0.012219484,
-0.013928876,
-0.0043736403,
0.0068442463,
0.021420822,
0.0048377137,
-0.011605171,
-0.030021202,
0.0005750836,
-0.008807377,
0.00043652937,
0.020766445,
-0.0001810178,
-0.016078971,
0.0012219484,
-0.02453245,
-0.029113088,
-0.0134547865,
0.0048377137,
0.018015392,
-0.021260567,
-0.0037760208,
0.0129673425,
0.0016409497,
0.013995649,
-0.0037559888,
-0.017614754,
-0.008012776,
0.00097154913,
0.017708234,
-0.035389762,
0.030395132,
0.0010608581,
-0.0047108447,
-0.017988682,
-0.0048310366,
0.0057024257,
-0.011665267,
-0.023878073,
-0.012780378,
-0.0045472505,
-0.01866977,
0.016012197,
0.009708813,
0.020419225,
0.015144147,
0.0048610843,
0.009855715,
-0.022983313,
-0.0018946877,
-0.02721673,
-0.028498774,
0.010056034,
0.0113714645,
-0.0081262905,
-0.005007985,
-0.007839166,
-0.0065237354,
-0.0043736403,
0.0068442463,
0.021460885,
-0.010603574,
-0.004390334,
-0.0053385124,
-0.007391786,
-0.014276097,
-0.004123241,
0.054166365,
0.005258384,
-0.012139356,
-0.00006286064,
0.00017267115,
-0.020819863,
0.013688493,
0.02704312,
0.011712008,
-0.007345045,
-0.030208167,
0.0076989424,
-0.013835394,
-0.013808684,
0.03859487,
0.018015392,
-0.012132678,
0.0022936573,
0.0005525477,
0.016346063,
-0.011191177,
0.0003785202,
0.005615621,
-0.0057257963,
-0.013047471,
0.007345045,
0.009134565,
0.0016159099,
0.0030415163,
0.00013698926,
-0.01593207,
0.011765426,
0.004640733,
0.0357904,
0.008019454,
0.005929454,
0.004336915,
-0.043001898,
-0.010082743,
0.022582674,
-0.012746992,
-0.0071447254,
0.013394691,
0.022929894,
-0.004640733,
0.020245615,
0.021247212,
-0.015518077,
-0.019257372,
-0.0014397957,
-0.00024059195,
-0.0022101908,
-0.02271622,
0.017067213,
-0.0019931782,
-0.02095341,
-0.019417627,
-0.01352156,
-0.009615332,
-0.032718837,
0.005952825,
0.011264628,
-0.008680508,
-0.023557562,
0.018322548,
-0.16933668,
0.0017861814,
0.009969229,
-0.012052551,
0.0036658451,
0.007665556,
0.01697373,
0.010443319,
-0.015397885,
-0.011992455,
0.013808684,
-0.0045272186,
-0.02005865,
-0.0036257813,
0.009415012,
-0.0066773137,
-0.031249827,
0.022742929,
0.01322108,
0.027376985,
0.026468871,
-0.012506608,
0.03258529,
-0.03151692,
0.02487967,
0.0070378883,
-0.03613762,
0.006617218,
0.012299611,
-0.013267822,
-0.015892006,
-0.015237629,
0.039876916,
0.021955008,
-0.0062666587,
-0.008753958,
0.00043611205,
-0.005805924,
0.0055989274,
0.022302227,
0.023250405,
0.017654818,
-0.0037593276,
0.001824576,
0.0082264505,
0.025039926,
-0.013675138,
-0.028204972,
0.0065804925,
-0.012266225,
-0.00025770257,
-0.020552771,
-0.0007674737,
-0.024145165,
0.011004212,
0.004610685,
-0.026228487,
0.010777184,
0.016987085,
-0.017841782,
-0.0056456686,
-0.027911171,
0.041265797,
-0.010590219,
-0.012980698,
-0.032505162,
-0.008072872,
-0.03247845,
-0.0065704766,
0.008667153,
-0.023410661,
-0.0037226023,
0.0047509084,
-0.010884021,
0.034802157,
0.02343737,
-0.011137759,
0.012853828,
0.01431616,
0.007972713,
-0.005191611,
0.026776027,
-0.0025407178,
0.007298304,
-0.018015392,
-0.006236611,
-0.017948618,
0.01642619,
-0.0011359779,
-0.0033369875,
0.0076989424,
-0.040517937,
0.0124798985,
-0.005739151,
0.00034742896,
0.006179854,
-0.0071514025,
-0.009054437,
0.009281466,
-0.019778203,
0.004707506,
-0.0017294242,
0.005936132,
0.007071275,
0.01812223,
-0.0057024257,
-0.011939037,
0.006730732,
0.03760663,
-0.011758749,
-0.037660047,
-0.008506898,
-0.00033970832,
0.04190682,
-0.02239571,
0.03322631,
0.015638268,
0.0032468436,
0.0019130503,
-0.030341713,
0.07184789,
-0.0011885618,
-0.034775447,
0.028659029,
-0.004253449,
-0.02793788,
-0.12638819,
-0.018856734,
0.029113088,
0.030555386,
0.022529256,
0.011685299,
0.0026659174,
0.016412837,
0.007845843,
0.03659168,
-0.002922994,
-0.01809552,
-0.007351722,
-0.030929316,
0.023223696,
-0.0008597041,
0.004006388,
-0.023196988,
-0.027230084,
0.043509375,
-0.025026571,
-0.032344908,
0.0016501311,
0.0019948473,
-0.0021617801,
-0.007104662,
-0.030956026,
0.028845994,
-0.005872697,
0.03832778,
0.042494424,
-0.0038261006,
-0.00080962427,
-0.020018585,
-0.04465787,
-0.013548269,
-0.019137181,
-0.021113666,
0.03611091,
-0.029406888,
0.0019047037,
0.0119590685,
0.034908995,
0.0068308916,
-0.0002476866,
0.031543627,
-0.029807527,
0.007498623,
-0.015397885,
-0.019257372,
-0.018749896,
-0.009415012,
-0.015972134,
0.022061843,
0.019591238,
0.010697057,
0.020592835,
-0.037633337,
-0.030154748,
-0.005378576,
-0.012666863,
0.0007357565,
-0.011798813,
0.012947311,
-0.0049846144,
-0.020699672,
-0.0194844,
-0.0023921477,
-0.008707217,
0.00063768344,
-0.013201049,
0.002195167,
-0.008293224,
0.0047776178,
-0.037099153,
0.0030448548,
-0.025547402,
-0.0010825595,
0.009808973,
0.0029113088,
-0.025240244,
-0.0072649173,
0.005682394,
0.00034075166,
0.02632197,
0.012833796,
-0.015531431,
-0.014169259,
-0.011338078,
-0.02967398,
-0.003176732,
0.019123826,
0.003832778,
-0.014756863,
-0.003548992,
0.005825956,
0.007518655,
-0.014957182,
-0.011805491,
-0.001712731,
-0.0100426795,
-0.024746124,
-0.049599085,
0.0049278573,
0.018549576,
-0.007244885,
0.0016184138,
0.011164468,
0.017601399,
0.0036224425,
0.013728556,
-0.026936283,
-0.0238113,
0.005825956,
-0.018362612,
-0.0035423147,
-0.0297274,
-0.00790594,
0.004997969,
0.010049357,
0.031784013,
0.012573381,
-0.023597626,
0.019925103,
-0.016773412,
0.041132253,
0.00753201,
-0.015491367,
-0.011511688,
0.009421689,
-0.011858908,
-0.021567723,
-0.0053418507,
-0.005068081,
-0.013107566,
0.005972857,
-0.0037693435,
-0.029059669,
0.00676078,
0.034935705,
0.016559737,
0.027083183,
0.000027257003,
-0.013701848,
0.0038060688,
-0.0074518817,
-0.006917697,
0.013020761,
-0.01573175,
0.015411239,
0.0023804624,
-0.010069389,
0.007899262,
-0.010376546,
0.0049078255,
-0.021233857,
-0.029860945,
0.011424883,
0.011204532,
0.00787923,
0.02542721,
-0.019751493,
0.031570338,
0.0010917408,
-0.0058393106,
-0.00067315664,
0.008493543,
-0.002338729,
-0.019898394,
-0.016933667,
0.011565107,
-0.00028503782,
-0.041666437,
-0.008880827,
-0.009955875,
0.0024672674,
0.018309193,
0.00085803476,
0.004997969,
0.013795329,
-0.0067273933,
-0.011264628,
-0.0012319643,
-0.014022359,
-0.011651912,
0.009415012,
0.030475259,
0.023196988,
-0.008987664,
0.043936722,
-0.013394691,
0.014903763,
-0.0066372496,
0.021768043,
-0.026295261,
0.00016390719,
-0.0064335917,
0.03584382,
0.00043986802,
-0.0006143128,
0.015851943,
0.04973263,
-0.0013045801,
0.011985778,
-0.0143295145,
-0.041319218,
-0.02256932,
-0.0067574414,
-0.028525483,
-0.030902607,
-0.01613239,
0.015023955,
0.023063442,
0.018148938,
0.013688493,
0.011838877,
-0.013982294,
-0.00330527,
-0.020072004,
-0.0006155648,
-0.02346408,
0.035550017,
-0.0021634495,
-0.0022752946,
0.0017310935,
0.010843957,
0.027537242,
0.01642619,
0.031089572,
-0.013040793,
0.016573092,
-0.004016404,
0.03872842,
0.011651912,
0.018723188,
-0.015291048,
0.0008688854,
-0.025734367,
-0.024746124,
0.00025415525,
0.0057224575,
0.09043753,
0.019016989,
0.0041599665,
0.015745105,
-0.022876477,
-0.0010124476,
0.008386706,
0.009682105,
-0.026789382,
-0.04583308,
0.038915385,
-0.009969229,
0.0057892306,
-0.015010601,
-0.016185807,
0.021701269,
-0.00041816675,
0.032051105,
-0.024465676,
-0.022636093,
0.012660187,
-0.024452321,
0.0070846295,
0.0059461477,
0.0009014373,
-0.027884461,
0.03397417,
0.0070645977,
-0.024799543,
0.0063334317,
0.004987953,
0.013848748,
-0.028792575,
0.004447091,
0.014276097,
-0.010650315,
0.004139934,
-0.027670788,
0.013541591,
0.017734945,
-0.013267822,
0.022622738,
-0.0129005695,
0.015825232,
-0.02970069,
-0.025814494,
-0.013381336,
-0.011451593,
-0.044524327
] |
Glioblastoma multiforme (GBM) is a particularly aggressive brain tumor and remains a clinically devastating disease. Despite innovative therapies for the treatment of GBM, there has been no significant increase in patient survival over the past decade. Enzymes that control epigenetic alterations are of considerable interest as targets for cancer therapy because of their critical roles in cellular processes that lead to oncogenesis. Several inhibitors of histone deacetylases (HDACs) have been developed and tested in GBM with moderate success. We found that treatment of GBM cells with HDAC inhibitors caused the accumulation of histone methylation,
|
[
-0.0302772,
-0.009921565,
0.0062519,
-0.05345818,
-0.010466922,
0.0088374205,
-0.022129688,
0.013916473,
-0.02628229,
-0.007444459,
-0.00010831178,
0.020000823,
0.02328611,
0.0058938037,
-0.011951872,
0.008002957,
0.049857505,
0.0047209566,
-0.03188042,
0.027386148,
-0.02754384,
0.007056795,
0.024258554,
-0.014823212,
-0.008955691,
0.021761738,
0.008469468,
-0.048017744,
0.00837748,
-0.0025838776,
0.0106114745,
0.000441871,
-0.011748184,
0.020368775,
-0.005778819,
0.00081351906,
0.019462036,
-0.015677387,
0.0064161643,
-0.004063899,
0.00791754,
0.0025148867,
0.007970105,
0.006179624,
-0.017701123,
-0.0036203857,
-0.0012894749,
-0.029777836,
-0.017950805,
0.021275515,
0.0133842565,
0.021196667,
-0.003939058,
0.0111108385,
-0.015585398,
-0.009448484,
0.0109859975,
0.031039385,
0.020946985,
0.00092562946,
-0.005128332,
-0.01697836,
-0.024941893,
0.004336578,
-0.005952939,
0.03385159,
-0.0034462654,
0.0017444871,
0.011275102,
0.0033772744,
0.02570408,
0.012221266,
-0.021998277,
-0.006859678,
0.010407787,
-0.028542567,
-0.033562485,
-0.01733317,
-0.002881196,
0.011459079,
0.026650243,
-0.0037780793,
-0.006008789,
0.012286971,
0.0127469115,
0.002950187,
-0.017398877,
-0.016833806,
0.017885098,
-0.00825921,
-0.0052794553,
-0.0046979594,
0.018910108,
0.015611681,
-0.01457353,
0.018161062,
-0.0032902143,
0.021709172,
0.010204099,
-0.011169974,
-0.0012024149,
0.0150203295,
0.0002669295,
-0.020933844,
-0.037820216,
0.0145209655,
0.014245002,
0.012681206,
0.013548521,
0.0047176713,
-0.013732497,
0.018437028,
-0.0035842473,
-0.046756197,
0.033904154,
0.00430701,
0.04176256,
0.007615294,
0.021656608,
-0.013482816,
0.008581168,
0.0145209655,
0.028148334,
-0.019882552,
0.004852368,
-0.005010062,
-0.03245863,
-0.024587084,
0.008771715,
0.007076507,
0.031696443,
0.008633733,
-0.00068991014,
0.00013592873,
-0.03611187,
0.0058346684,
0.0072013475,
-0.012556365,
-0.016071621,
-0.041236915,
0.0067282664,
0.038924072,
-0.010880869,
-0.0022060699,
-0.030802844,
0.012490659,
0.014586671,
0.021091538,
0.014415837,
-0.001984313,
0.006238759,
-0.01055234,
0.029278472,
0.0011629914,
0.0073590414,
0.007319618,
0.002794136,
0.03372018,
-0.036979184,
0.009211943,
-0.009264507,
-0.00917909,
0.026361138,
0.011459079,
0.02076301,
0.032537475,
-0.011794178,
0.0040343315,
0.0063143205,
-0.024245413,
-0.0024245414,
0.052459452,
-0.052117784,
0.0038503555,
-0.019238638,
0.029804118,
0.005289311,
0.039186895,
-0.021538338,
-0.0058116717,
-0.0074641705,
0.01961973,
0.01869985,
-0.012188412,
-0.010907151,
0.0007667037,
0.012970311,
-0.011051703,
0.017254325,
-0.055613328,
0.0072539123,
0.028148334,
0.002454109,
-0.018292474,
-0.6337186,
-0.034166977,
0.01883126,
-0.006547576,
0.011077985,
0.042183075,
0.018988956,
-0.017687982,
0.0011868097,
0.011209397,
-0.011452508,
0.024626506,
0.015059752,
-0.027517559,
-0.019685436,
-0.020907562,
-0.01043407,
-0.018410744,
0.010105541,
-0.008180363,
-0.01915979,
0.003153875,
-0.032721452,
-0.012438094,
0.00418874,
0.017201759,
0.020736728,
0.0015235515,
-0.017398877,
0.037110593,
-0.042156793,
0.03808304,
-0.018910108,
0.010013552,
0.053484462,
0.0008599237,
-0.004290584,
0.03164388,
0.0069253836,
0.023719767,
0.00688596,
-0.012102995,
0.02420599,
-0.003774794,
-0.024153424,
0.032327216,
0.007818982,
0.0085877385,
0.0043891426,
-0.0122475475,
0.007878116,
0.018331898,
-0.015756233,
0.0024820338,
0.021025833,
0.028963085,
0.015743092,
-0.0137587795,
0.011735043,
-0.002311199,
-0.0022487785,
0.02604575,
-0.010756028,
-0.025572669,
-0.024245413,
0.0055389926,
-0.01801651,
0.015217447,
-0.013403968,
0.009665312,
-0.0041394606,
0.02227424,
0.0057328246,
0.0033230672,
0.038030475,
0.02086814,
0.005427293,
-0.0010406144,
-0.013837626,
0.009514189,
0.012865181,
-0.013969038,
-0.03350992,
0.007365612,
0.029515013,
-0.011491932,
0.0055554193,
0.012240977,
-0.0019859555,
-0.004395713,
0.020736728,
0.011682479,
-0.002628229,
-0.041236915,
-0.021722313,
-0.0005905302,
0.017188618,
0.01653156,
0.020355634,
-0.023220403,
-0.02720217,
-0.006560717,
0.01813478,
0.0067874016,
-0.008062093,
0.0100924,
-0.023614638,
0.00522032,
0.05127675,
-0.012687776,
-0.008975402,
0.0023144842,
-0.0019301057,
0.01147222,
-0.0027350008,
-0.02088128,
-0.003922632,
-0.011117409,
-0.023930026,
-0.034929164,
0.004008049,
-0.00038807446,
-0.0019087513,
-0.010230382,
0.026742231,
-0.004119749,
0.006665846,
-0.018778697,
-0.022392511,
0.009777012,
0.002025379,
-0.014021602,
0.022234818,
-0.026426844,
0.01914665,
0.014639236,
0.009573325,
-0.021472631,
0.012536652,
-0.03466634,
-0.014442119,
-0.007529876,
0.010802021,
0.031381056,
-0.020289928,
0.00059956475,
-0.017582852,
-0.008055522,
0.002812205,
-0.0022159256,
0.0053188787,
0.014350131,
0.0061927647,
0.019987682,
0.038240734,
-0.019514602,
-0.0034265537,
-0.024403106,
-0.0019251778,
-0.02099955,
0.0073853238,
0.005818242,
-0.0028384875,
-0.0030783133,
-0.01869985,
-0.033799026,
-0.011301385,
0.021617183,
-0.019948259,
-0.017858816,
-0.00039361836,
-0.018975815,
-0.0075233057,
0.0048063737,
0.0037550824,
0.012004436,
-0.0058018155,
-0.002444253,
0.009862429,
0.00046035074,
-0.002776067,
-0.011478791,
-0.0007897007,
-0.009271078,
0.048674803,
0.022839312,
0.024955036,
0.00023387132,
-0.0028762682,
0.014179296,
-0.010250093,
0.029909248,
-0.0031604455,
0.00052852044,
0.0032655746,
-0.022300525,
-0.0043891426,
0.001509589,
0.0096127475,
0.0332471,
0.03797791,
-0.02042134,
0.012661493,
-0.011117409,
0.019356906,
-0.010217241,
0.0017839104,
-0.01834504,
-0.011183115,
0.0020533039,
-0.003309926,
-0.0011498502,
-0.014665518,
-0.00066568115,
-0.007700711,
-0.01755657,
-0.0068793898,
-0.0072079184,
-0.02282617,
-0.03797791,
-0.0060974914,
0.008817709,
-0.008016098,
-0.012700917,
-0.0004422817,
0.01722804,
0.011886166,
0.02328611,
0.0035513944,
-0.028647697,
-0.0053615873,
0.03293171,
-0.0028286316,
-0.005289311,
0.004323437,
0.0010619689,
0.024481954,
-0.006366885,
0.04636196,
-0.016702397,
-0.0059233713,
0.0072801947,
-0.0070370836,
-0.0012574433,
0.011767896,
0.006564002,
0.031827856,
0.0071290713,
-0.015913928,
-0.0054338635,
-0.026558256,
0.0068925307,
-0.0027612832,
0.004970638,
0.0387401,
-0.031854138,
0.013495957,
0.018804979,
0.044706177,
0.0071882065,
0.005653978,
-0.0056966865,
-0.015335716,
-0.023640921,
-0.0068333955,
-0.0009946205,
0.027938075,
-0.00011806498,
0.003590818,
0.004865509,
-0.025414975,
-0.024981318,
0.008324916,
-0.045731187,
0.0078058406,
-0.0011326025,
-0.011255391,
0.004750524,
0.010690322,
0.013206851,
-0.0021830727,
-0.02720217,
0.03211696,
0.007970105,
-0.0022027844,
-0.021420067,
-0.0074970233,
-0.0055258516,
-0.002030307,
0.019921977,
0.022077125,
0.022931298,
-0.012306683,
0.009836148,
-0.01722804,
-0.010112111,
-0.005082338,
-0.0051447586,
0.0176617,
-0.010046406,
0.01295717,
-0.012188412,
-0.0034101272,
-0.0069910893,
0.00952733,
0.018437028,
-0.0332471,
-0.008666585,
-0.0020861567,
-0.028700262,
-0.003922632,
-0.01021067,
0.013719356,
-0.01961973,
0.010020124,
0.014691801,
0.013798202,
0.02269476,
0.008016098,
0.018292474,
-0.0112356795,
-0.03266889,
-0.002559238,
0.0018594721,
0.030066941,
0.026768513,
-0.022353088,
0.0121358475,
0.024876188,
0.016702397,
-0.018384462,
-0.011629914,
0.015283152,
-0.020960126,
0.0064293053,
0.019435754,
-0.0102238115,
0.0062124766,
-0.0031752293,
0.008403762,
-0.020513328,
-0.024127143,
-0.023640921,
-0.013666791,
0.0014652377,
-0.0008747075,
0.029462447,
0.025506964,
0.03626956,
-0.009382778,
-0.0022159256,
0.023325533,
0.00072317367,
-0.0070370836,
-0.006564002,
-0.0042643016,
0.0026479408,
0.0150334705,
0.0026035896,
-0.017359452,
0.016965218,
-0.008278921,
0.029409884,
0.009678453,
0.007562729,
-0.00073097623,
0.011767896,
0.0149152,
0.014034743,
-0.018778697,
0.0020089527,
0.0044088545,
-0.016938936,
-0.016715538,
0.019724859,
-0.012562935,
-0.030119505,
-0.0043989983,
0.015453987,
-0.0021518625,
0.01377192,
-0.0054305783,
0.003669665,
0.013601085,
0.01078231,
-0.029988093,
0.0022027844,
-0.014021602,
0.019659154,
0.007319618,
-0.014704942,
-0.002186358,
-0.006931954,
-0.0029074785,
0.007299906,
-0.024613366,
-0.018174205,
0.0018085501,
0.032195807,
-0.006672417,
-0.00047061726,
-0.03910805,
-0.0036630942,
0.03348364,
-0.017582852,
-0.00075274124,
-0.0053681578,
-0.027254736,
0.010276375,
-0.010026694,
0.007792699,
-0.011491932,
-0.016452715,
0.00768757,
0.016439574,
-0.009126525,
0.015519693,
0.0277541,
-0.01215556,
0.0052630287,
0.0061730533,
0.017083488,
-0.0009773728,
-0.014258143,
-0.0067479783,
-0.0022553492,
-0.013029446,
-0.026006326,
-0.00046117208,
-0.01421872,
0.01089401,
-0.014481543,
-0.01285204,
0.0007289229,
-0.000104564504,
-0.00035070433,
-0.0007235843,
-0.006780831,
0.017701123,
-0.0021797875,
0.0061763385,
0.013890191,
0.008344627,
0.007089648,
0.00527617,
-0.023811756,
0.036637515,
-0.011340808,
-0.0040441877,
0.0022224963,
0.017609134,
-0.008384051,
-0.020960126,
-0.028069487,
0.00045336952,
0.045047846,
0.0010562196,
0.0062256176,
-0.029436165,
-0.027044477,
0.0021288656,
0.009336784,
0.005565275,
-0.028779108,
-0.01582194,
0.00378465,
-0.005782104,
-0.009152808,
-0.023364957,
-0.03797791,
0.008469468,
0.008180363,
0.01640015,
-0.0038733527,
0.0109991385,
-0.0032475055,
-0.015007189,
-0.011215968,
-0.023903744,
-0.021012692,
-0.0038832084,
0.020749869,
0.026308574,
0.036611233,
0.03753111,
-0.007076507,
0.00872572,
0.02661082,
0.020697305,
-0.0038864939,
0.00041045545,
0.004428566,
-0.03064515,
0.01846331,
-0.0029567578,
-0.017806252,
0.026965631,
-0.018187346,
0.013213422,
0.01411359,
0.0014742722,
-0.028936801,
-0.008167222,
-0.03303684,
-0.027386148,
0.009330213,
-0.02603261,
0.0049049323,
-0.04278757,
-0.020815574,
0.037373416,
0.028411156,
0.0099807,
0.0072539123,
0.010447211,
0.0015703669,
0.0034199832,
0.009882142,
0.00015297114,
-0.007161924,
-0.01914665,
-0.003705803,
-0.010184388,
0.003866782,
0.0015235515,
0.011892737,
0.006012074,
-0.04299783,
0.013955897,
0.015493411,
-0.03708431,
-0.010572052,
-0.024757918,
-0.02098641,
-0.02398259,
0.0022077125,
-0.0022356373,
-0.027885512,
0.0028499858,
-0.0018808264,
-0.020749869,
0.005463431,
-0.025257282,
-0.0069122426,
0.04270872,
-0.005952939,
0.032169525,
-0.0057525365,
0.015703669,
0.015677387,
0.0041066078,
-0.0013855696,
-0.0021699315,
-0.0068728193,
0.0031045957,
0.039896518,
0.010729745,
0.004780092,
-0.0067282664,
-0.00917909,
0.013561662,
-0.0112356795,
-0.020828716,
0.010887439,
-0.011629914,
0.000037780792,
-0.005414152,
-0.025336128,
-0.02914706,
0.020920703,
0.0058905184,
0.02098641,
-0.016820665,
-0.02145949,
-0.012484089,
0.020815574,
-0.00029731842,
0.008528603,
-0.0048917914,
-0.010250093,
-0.002932118,
-0.01193873,
-0.015046611,
0.02307585,
-0.024508236,
0.02166975,
-0.024022015,
0.00050921936,
0.019067802,
-0.005200608,
0.014034743,
-0.010355223,
0.019698577,
0.03611187,
-0.010204099,
-0.004008049,
0.043234367,
0.0028023492,
0.016768102,
0.004083611,
0.0017017784,
-0.022878734,
-0.002909121,
-0.008160652,
0.0067874016,
0.029541295,
-0.01205043,
0.00648187,
-0.017464582,
-0.009829577,
-0.02925219,
-0.02042134,
0.017109772,
-0.028516285,
-0.008811138,
-0.0008911339,
0.018161062,
0.022878734,
0.016255597,
-0.011038562,
-0.005345161,
0.040211905,
-0.011301385,
0.011629914,
0.016071621,
-0.0072801947,
-0.004484416,
0.010407787,
-0.0099741295,
-0.036322124,
-0.0021075113,
-0.024836766,
-0.016492138,
-0.021249233,
-0.010447211,
0.012786334,
0.019738,
-0.025888057,
0.00051168335,
-0.0075890115,
0.029304754,
-0.01411359,
-0.02396945,
0.024955036,
-0.03566507,
-0.008430045,
0.0075561586,
-0.0062453295,
-0.036427256,
0.02144635,
-0.004622398,
-0.0021420068,
-0.026347997,
-0.004461419,
-0.016715538,
-0.003705803,
0.0051546143,
0.029225908,
0.032300934,
-0.036874056,
-0.024140283,
-0.009211943,
0.003144019,
0.002836845,
-0.014507825,
-0.003282001,
-0.01457353,
0.0037616529,
-0.025861774,
0.010703463,
-0.022445077,
-0.03508686,
-0.04431194,
0.01044064,
-0.019107226,
0.031538747,
0.005410867,
0.00539444,
-0.028200898,
-0.01170219,
-0.05256458,
0.010907151,
0.018804979,
0.028253462,
0.024048297,
0.023496369,
-0.021748595,
-0.0010438998,
-0.0064687287,
0.01457353,
0.015927069,
0.006340603,
0.010230382,
-0.01320028,
0.016505279,
-0.012661493,
-0.024823625,
-0.013548521,
0.005653978,
-0.0023489797,
-0.02972527,
0.021301797,
0.009054249,
0.00470453,
0.0006775903,
0.010138393,
-0.0041098935,
0.020447623,
0.015572257,
-0.01937005,
0.0069910893,
0.0020648025,
0.0031883705,
-0.001514517,
-0.002836845,
0.0076612877,
-0.023746049,
0.01399532,
-0.003866782,
-0.019120367,
-0.0052794553,
-0.016610408,
0.0075693,
0.018542156,
0.02328611,
0.017990228,
0.0070633655,
-0.012536652,
-0.010125252,
-0.005778819,
-0.011518214,
-0.012037289,
0.0053845844,
-0.04220936,
-0.01617675,
0.016426431,
0.014389554,
-0.02316784,
-0.013929614,
-0.005148044,
-0.00952076,
-0.033325944,
0.02410086,
-0.005906945,
-0.008285493,
-0.014612954,
0.014363272,
-0.022721041,
0.0015514765,
-0.019764284,
0.0047702356,
-0.015913928,
0.0035941033,
-0.0072604828,
0.010723175,
0.007615294,
0.008870273,
-0.015677387,
-0.014139872,
-0.006527864,
0.18029651,
-0.025086446,
-0.015545975,
-0.0043661455,
-0.005243317,
-0.008850561,
0.021183526,
0.012352677,
0.0019810277,
-0.0052038934,
0.024442531,
-0.0038832084,
-0.018778697,
0.0020188084,
0.022313666,
-0.013601085,
-0.05358959,
-0.012595788,
-0.0056145545,
-0.014612954,
-0.0029304754,
0.009435343,
-0.007832123,
0.003738656,
0.0100858295,
-0.011853313,
-0.02649255,
0.01674182,
0.020132234,
0.0014800215,
-0.010315799,
0.002232352,
0.0009979057,
0.0027432141,
-0.0016574269,
-0.0016574269,
-0.028752826,
-0.027727816,
-0.020920703,
0.012779764,
0.006619852,
0.029804118,
-0.021301797,
0.015401422,
-0.01662355,
0.0048260856,
0.0054174373,
-0.0027596406,
-0.0063471734,
-0.00079627126,
-0.041709997,
0.012865181,
0.0056835455,
0.034245826,
0.020710446,
0.0043694307,
0.014389554,
-0.0030963824,
-0.014757507,
0.009947847,
-0.004175599,
-0.0041460316,
-0.01927806,
0.0382933,
0.011406514,
0.03716316,
-0.03085541,
0.001072646,
0.039449718,
0.012773193,
0.008173793,
-0.005749251,
-0.029225908,
-0.0030438178,
0.00941563,
-0.021144103,
0.039423436,
0.013285698,
0.019580306,
0.015598539,
0.004451563,
0.008876843,
-0.011597061,
0.005860951,
-0.018844403,
-0.053642157,
0.02396945,
0.011971584,
-0.019251779,
-0.0014718083,
0.017740546,
0.0013781777,
-0.0074641705,
0.018003369,
0.014941483,
0.0057656774,
-0.011925589,
0.017280607,
-0.014849494,
-0.020473905,
-0.040395882,
0.066757016,
-0.012234407,
0.017504007,
-0.0031275926,
0.010808592,
-0.013325121,
0.014415837,
-0.0037780793,
0.0103486525,
0.005831383,
-0.03211696,
0.008443186,
-0.02591434,
-0.01296374,
0.023102134,
-0.0033082834,
-0.020933844,
0.033404794,
-0.021827443,
0.0004153834,
-0.02856885,
-0.0063997377,
0.028306028,
-0.03085541,
0.002416328,
-0.03282658,
0.0016245741,
-0.010164676,
-0.031827856,
-0.035507374,
-0.014166155,
-0.0043201516,
-0.008758574,
0.0027793522,
0.0021436494,
0.033772744,
0.009310502,
-0.017806252,
0.02030307,
-0.010604904,
0.009901853,
-0.001650035,
0.020894421,
0.0008591024,
-0.023456944,
0.010289517,
0.01722804,
-0.0073918942,
-0.021709172,
-0.0135090975,
-0.014166155,
-0.023562074,
0.0036203857,
0.03051374,
-0.02157776,
-0.013101722,
-0.030697716,
-0.010072688,
0.025283564,
-0.03750483,
0.011781037,
0.032642607,
-0.03201183,
-0.004060614,
0.0123723885,
-0.16421175,
0.00298304,
0.015927069,
-0.026768513,
0.031932984,
0.014389554,
0.00963246,
-0.01078231,
-0.0031867279,
0.011452508,
0.01663669,
-0.0097244475,
-0.05061969,
-0.03684777,
0.018069075,
0.0025855203,
0.027859228,
0.04875365,
0.025546387,
0.0018282619,
-0.021617183,
-0.024863048,
-0.0028877668,
-0.010539198,
-0.0014192438,
0.018804979,
0.009783583,
0.01239867,
-0.016715538,
-0.0073261885,
-0.01583508,
0.00009193669,
0.01216213,
0.0019448895,
0.02490247,
0.010184388,
0.006606711,
-0.0021436494,
-0.025625234,
-0.010624616,
0.0034035568,
0.024481954,
-0.009731018,
0.008121228,
0.009481336,
0.023364957,
0.013482816,
-0.008850561,
0.005920086,
0.016689254,
0.02671595,
-0.002278346,
0.004875365,
0.013535379,
0.027780382,
0.018910108,
0.013679933,
0.008048952,
0.001698493,
-0.024560802,
-0.021262374,
-0.010946575,
0.024626506,
-0.010118682,
-0.005690116,
-0.02215597,
-0.008278921,
-0.014836353,
-0.031249644,
-0.000012563653,
-0.02180116,
0.0011506715,
0.01881812,
-0.020841857,
0.016452715,
0.002288202,
0.007707282,
-0.00062297244,
0.0009872286,
0.011012279,
-0.011340808,
0.008252639,
-0.028726544,
-0.013850767,
0.0048786504,
0.0052236053,
0.007930681,
0.018752415,
-0.011314526,
-0.008423475,
0.030986821,
-0.0025280279,
0.013009734,
-0.00139214,
0.027727816,
0.015401422,
-0.013344834,
-0.010112111,
0.006586999,
-0.008292063,
0.021853724,
-0.0026052322,
-0.026965631,
0.00584781,
0.063971095,
0.0132725565,
-0.020132234,
0.009914994,
0.043444626,
-0.00016713895,
-0.028174616,
0.008870273,
-0.014179296,
-0.008357769,
0.0033362084,
0.019028379,
-0.0006328283,
-0.010933433,
-0.011150262,
-0.0062617557,
0.072013475,
0.006619852,
-0.006435876,
0.0049147885,
-0.00028746255,
-0.0055094254,
-0.12899348,
-0.005378014,
0.0021436494,
0.0019136793,
-0.005985792,
0.020250505,
0.00046897464,
0.013837626,
-0.023693485,
0.022195395,
-0.03808304,
0.0006759477,
-0.0056605483,
-0.02064474,
0.010703463,
-0.0028696978,
0.006389882,
-0.011827031,
-0.026886784,
0.03211696,
-0.008272351,
0.009297361,
-0.012168701,
-0.010979427,
0.013226563,
0.010907151,
-0.023246687,
0.01926492,
0.011051703,
0.016268738,
0.015900785,
-0.01858158,
0.010802021,
0.009047679,
0.0029206197,
-0.0048063737,
0.015059752,
-0.02479734,
0.017819393,
-0.009192231,
-0.0041066078,
0.020171659,
0.014560389,
0.005644122,
0.016649831,
-0.01467866,
-0.018279333,
-0.0036400973,
0.028463721,
-0.00011560101,
-0.021038974,
-0.035770196,
-0.0135090975,
-0.004448278,
0.019632872,
-0.025165293,
0.013265986,
0.022195395,
-0.035743915,
0.023036428,
-0.006547576,
0.0050659114,
-0.014902059,
-0.017070347,
0.0011892737,
-0.01169562,
-0.029094497,
-0.03395672,
0.0035054006,
-0.020316212,
0.0039521996,
0.003010965,
-0.01421872,
-0.020960126,
-0.03923946,
-0.0033592053,
-0.0013445035,
-0.0074181766,
0.01641329,
0.0018364751,
-0.03064515,
-0.016084762,
0.009533901,
-0.012950599,
0.021065256,
-0.005637551,
-0.012438094,
-0.006334032,
0.0026988627,
-0.02672909,
0.012799475,
0.06044927,
-0.009041108,
-0.024468813,
-0.016084762,
0.023246687,
-0.014231861,
-0.016833806,
0.023654062,
0.039476,
-0.016203033,
-0.02318098,
-0.05566589,
0.019711718,
-0.0039850525,
-0.0062946086,
0.015401422,
0.00032668066,
0.016886372,
0.004970638,
0.00041435673,
0.0014972693,
0.006859678,
0.0018512589,
-0.010749457,
-0.017280607,
-0.03795163,
-0.025033882,
0.038792662,
-0.004602686,
0.0040671844,
0.026991913,
0.017346311,
0.005676975,
0.00430701,
0.010263234,
-0.013969038,
-0.022037702,
-0.017648559,
0.035507374,
-0.024350543,
-0.032327216,
0.0067676897,
-0.021551479,
-0.0052827406,
-0.023956308,
-0.004793233,
-0.0155328335,
0.013982179,
0.014442119,
0.0023966164,
0.0520915,
-0.0021403641,
-0.030881692,
0.009869,
0.009593036,
0.0023604783,
0.006320891,
-0.030697716,
0.021735454,
0.00075931184,
-0.024140283,
0.03548109,
0.011715331,
0.0016935652,
-0.025677798,
-0.008410333,
-0.009382778,
-0.009428772,
0.00975073,
-0.008410333,
-0.0036729502,
0.014718083,
0.016189892,
-0.0051776115,
0.00007160898,
0.002546097,
0.01411359,
-0.012582647,
-0.003876638,
0.011117409,
-0.02649255,
0.0029222623,
-0.018147921,
0.0043497193,
-0.0019218925,
0.0061566266,
-0.008403762,
-0.00688596,
-0.005676975,
0.00091577356,
0.03613815,
0.019356906,
-0.010775739,
0.0035743916,
0.008114657,
0.021840584,
-0.0036860914,
0.0011629914,
0.008896556,
0.011005709,
-0.005036344,
0.013265986,
0.010217241,
0.009836148,
0.031039385,
0.014231861,
0.016570985,
-0.017306888,
0.0013264343,
-0.0021321508,
0.040317032,
-0.008048952,
0.01216213,
0.0121227065,
-0.00355468,
-0.019488318,
0.028831674,
-0.017385736,
-0.008160652,
0.00837091,
0.013587944,
0.024363684,
0.020723587,
-0.019002097,
-0.007319618,
-0.017858816,
0.016557842,
-0.0031013102,
-0.015046611,
-0.009586466,
0.0387401,
0.029882966,
-0.005703257,
0.0071356418,
-0.007214489,
0.01801651,
-0.005637551,
0.007897829,
-0.017201759,
0.00872572,
0.0005038808,
0.004865509,
-0.012576076,
-0.030671433,
0.0036335266,
0.008975402,
-0.017911382,
-0.011104268,
0.025086446,
0.00048047313,
0.085312314,
0.005588272,
-0.018397603,
0.014665518,
-0.01651842,
0.031749006,
0.009251366,
0.030934256,
-0.021709172,
-0.031275928,
0.0069253836,
-0.022681616,
0.0031834424,
-0.0403696,
-0.026124597,
0.021367503,
-0.015808798,
0.02993553,
0.005072482,
-0.008600879,
0.02640056,
0.00298304,
0.006320891,
-0.00418874,
-0.033010557,
0.007943822,
0.024153424,
0.010657469,
0.0020533039,
-0.0145341065,
0.008870273,
0.007700711,
-0.029515013,
-0.009356496,
-0.0059792213,
-0.015545975,
-0.00699766,
-0.04428566,
0.021617183,
0.0013773564,
-0.0036105297,
0.0057689627,
0.009185661,
-0.028700262,
-0.0040179053,
-0.029620143,
0.00095848227,
-0.017977087,
0.003485689
] |
BACKGROUND Long-lasting insecticide treated nets (LLINs) and indoor residual house spraying (IRS) are the main interventions for the control of malaria vectors in Zanzibar. The aim of the present study was to assess the susceptibility status of malaria vectors against the insecticides used for LLINs and IRS and to determine the durability and efficacy of LLINs on the island. METHODS Mosquitoes were sampled from Pemba and Unguja islands in 2010-2011 for use in WHO susceptibility tests. One hundred and fifty LLINs were collected from households on Unguja, their physical state was recorded and then tested
|
[
-0.00820724,
0.004203877,
-0.002891894,
-0.01630385,
0.0000067488418,
0.016718708,
-0.016248537,
-0.0030854933,
-0.012086146,
-0.028251711,
0.009396494,
0.0065962146,
0.028984625,
0.008718896,
0.009355009,
0.011830318,
0.028652739,
-0.005797616,
0.016815508,
-0.012003174,
-0.007035271,
-0.0051061893,
0.0008115626,
-0.009306609,
0.018253675,
0.0022523238,
0.007930669,
-0.031529076,
-0.012224431,
0.018198362,
0.0020224242,
-0.0015401539,
-0.016054938,
-0.001083812,
-0.04580013,
-0.023356408,
0.014409341,
-0.019899271,
0.0017821534,
0.018516418,
0.014022142,
0.010938377,
-0.0124042025,
0.0022419523,
-0.00424882,
0.02389572,
-0.0060119587,
0.020134358,
-0.029565424,
0.023840407,
0.010516606,
0.0062885294,
-0.014063627,
-0.011726604,
-0.007042185,
-0.022028867,
-0.0036818492,
0.0052928743,
0.012466431,
-0.033658672,
-0.017797334,
0.019207845,
-0.038443346,
0.008808781,
-0.013199343,
0.02912291,
-0.0035677638,
0.0047812182,
0.008546039,
0.012680773,
0.046906415,
0.038581632,
0.040075116,
0.00022384952,
0.016732536,
0.004618733,
-0.0150316255,
0.0057215593,
0.012943516,
-0.003747535,
0.025098804,
0.020438585,
-0.04209408,
-0.00273978,
0.029565424,
0.0050577894,
0.018378133,
0.028196398,
-0.0016222609,
0.004974818,
-0.019387616,
0.02599766,
0.01754842,
0.024227606,
0.011920203,
0.00040902235,
-0.020466242,
0.021268297,
0.0018547532,
-0.00938958,
-0.010219293,
-0.00203971,
0.0007791519,
-0.004442419,
-0.0036680207,
0.011892546,
-0.0002091567,
0.002335295,
0.023937207,
-0.025264746,
-0.005362017,
0.033271473,
0.012722258,
-0.026993314,
0.022775609,
-0.01953973,
0.0060085016,
-0.01983013,
0.0076471837,
0.0007285913,
0.016856993,
0.0073844413,
0.011498433,
-0.0015003968,
0.023010693,
0.0045184763,
-0.01620705,
-0.009880493,
-0.019940758,
-0.0044458765,
-0.014243399,
0.014257227,
0.009410323,
-0.013427515,
0.008933238,
0.017659048,
-0.03896883,
-0.0324141,
-0.03092062,
-0.01706442,
0.010246949,
0.01687082,
-0.008670496,
-0.010385235,
0.0062055583,
0.008186497,
0.0071631847,
0.020424757,
-0.009161409,
-0.01613791,
-0.013054144,
-0.034267128,
-0.0000027380242,
-0.0034847925,
0.0036680207,
0.0202035,
-0.01469974,
0.013952999,
-0.045578875,
-0.016939964,
-0.0056835306,
-0.008428496,
0.0051165605,
0.019276988,
0.0121898595,
0.023066008,
-0.004760476,
-0.00412782,
0.01620705,
-0.0026049516,
0.011795746,
0.022139495,
-0.026398687,
0.027823027,
-0.003647278,
0.022969209,
-0.004328334,
0.010226207,
0.007854612,
-0.011346319,
-0.023868063,
0.04087717,
-0.0061571584,
0.005946273,
-0.0044078478,
-0.0077923834,
0.0077716406,
0.015446481,
0.009921979,
-0.02360532,
0.015045454,
0.010703292,
0.001439897,
-0.013026487,
-0.6398743,
-0.017036764,
0.013572714,
-0.0056593306,
0.018087734,
0.001455454,
0.022664981,
-0.004414762,
-0.027740056,
0.046602186,
-0.0033516928,
0.004850361,
0.013379115,
-0.041209057,
-0.015570939,
-0.0196227,
-0.024199948,
-0.0030941362,
0.013081801,
-0.00042803658,
-0.009576266,
0.0049851895,
0.021475727,
0.021807611,
0.0060569015,
0.017479276,
0.022236295,
-0.0194291,
-0.002947208,
0.014381683,
-0.006122587,
0.031750333,
0.0022177524,
0.034654327,
0.047929727,
-0.02314898,
-0.013005744,
0.019899271,
0.015640082,
0.032303475,
-0.03224816,
-0.020466242,
0.044693846,
-0.0067379572,
-0.010641064,
0.023107493,
0.005866759,
0.005662788,
0.016096422,
0.004214248,
-0.0032134075,
-0.009603922,
-0.021807611,
0.011823404,
0.01792179,
-0.0023975235,
0.0041485624,
-0.019788643,
0.030422792,
0.013489743,
-0.019138703,
-0.0121345455,
-0.015985794,
-0.023688292,
-0.023550007,
0.00032734752,
0.0058805877,
0.030754678,
0.0041485624,
-0.007529641,
0.008421582,
0.031169534,
-0.021406583,
0.010461292,
0.007654098,
0.024075491,
0.01489334,
0.0068209283,
-0.01764522,
0.0002024585,
-0.012231345,
-0.022180982,
-0.021959724,
-0.005939359,
0.022664981,
-0.019180188,
0.0056558736,
-0.0065927575,
-0.001141719,
-0.0013949542,
0.013600371,
0.008843353,
-0.0068036425,
-0.009548608,
-0.007923755,
0.02390955,
-0.013102544,
-0.0022004668,
0.012418031,
-0.00853221,
-0.025361545,
-0.0071908417,
-0.008947067,
-0.023259608,
0.015003968,
0.0012627187,
-0.016262366,
0.011692032,
0.028237883,
-0.010032607,
-0.024490347,
0.0051476746,
-0.0022384953,
-0.014838026,
0.040655915,
-0.02939948,
0.017175049,
-0.00018636121,
-0.008407754,
-0.03711581,
0.016856993,
0.006869328,
0.026730571,
-0.025347717,
-0.015474139,
0.0016213965,
-0.011539918,
-0.00082798395,
-0.0036680207,
0.0011123334,
0.002139967,
0.014934826,
0.024891376,
-0.00464639,
0.013683342,
-0.0073291273,
0.02561046,
-0.004238448,
0.02229161,
-0.022208638,
-0.028652739,
-0.013545057,
0.0017026393,
0.01000495,
-0.0020345242,
-0.03529044,
-0.0016248537,
-0.0067103,
-0.013766314,
0.0065962146,
0.00840084,
-0.021212984,
-0.0040379344,
0.0039238487,
0.0071009565,
-0.007930669,
0.008884838,
-0.0110628335,
-0.025527488,
-0.0089194095,
0.008089697,
-0.0068762423,
0.0011520904,
-0.0150316255,
-0.0065132435,
-0.015930481,
0.047044702,
0.01670488,
0.008857181,
-0.033077873,
0.019415272,
-0.029676052,
-0.01010175,
0.03150142,
0.014879512,
0.01725802,
-0.01821219,
-0.021351269,
-0.0038754488,
-0.002923008,
0.010488949,
-0.010993691,
0.0096730655,
-0.0028123797,
0.01086232,
0.0071631847,
0.023135152,
0.020811956,
0.024144635,
0.031805646,
-0.013918428,
0.0046533043,
-0.008006725,
0.01575071,
-0.013254657,
0.00043970442,
0.010205464,
0.024116978,
-0.004853818,
0.018530246,
0.008463068,
-0.002383695,
0.009603922,
-0.020452414,
0.025002005,
-0.031335477,
0.0032687217,
-0.022803266,
0.043310992,
0.02031413,
0.015446481,
0.001835739,
-0.023453208,
-0.013545057,
-0.012003174,
0.024587147,
-0.009272037,
-0.0098874075,
0.004891847,
0.017797334,
-0.009355009,
0.0073567843,
0.025721088,
0.004241905,
-0.028625082,
-0.0051615033,
0.010710206,
0.014029056,
0.013240829,
-0.0017907962,
-0.013669514,
-0.0028262082,
0.0015721323,
0.016193222,
0.015059282,
0.01792179,
0.023453208,
-0.02114384,
0.044804476,
0.012507916,
0.02353618,
0.009977293,
-0.0006512379,
0.0153496815,
0.03387993,
0.0022160239,
0.035041526,
-0.000089561414,
-0.012922772,
0.033243816,
0.018156875,
0.023577664,
-0.025541317,
-0.0032462503,
-0.0077578123,
-0.030007936,
0.0070041567,
0.026301887,
0.037420034,
0.022941552,
0.019373788,
-0.031556733,
0.002423452,
-0.02778154,
0.01649745,
-0.0060845586,
0.00058339164,
-0.020424757,
-0.0010284978,
-0.0033810786,
-0.009921979,
-0.012936601,
0.02334258,
-0.0026723659,
0.020466242,
0.014001399,
0.00047622042,
-0.012687688,
0.011539918,
-0.010392149,
-0.023024522,
-0.014561455,
0.007944497,
0.0060914727,
-0.0051476746,
-0.037807234,
0.00071130565,
0.016774021,
-0.012867458,
-0.0039515058,
0.00835244,
0.011422376,
0.017755847,
-0.013731742,
0.005814902,
-0.018696189,
0.01612408,
-0.023660636,
-0.0008366268,
0.008469982,
0.015059282,
-0.012210603,
-0.0069522997,
-0.010191635,
0.020563042,
-0.013946084,
-0.0019913102,
-0.011242605,
0.004214248,
0.02455949,
-0.002127867,
-0.015916651,
-0.0046775043,
0.019318473,
-0.0025427232,
0.010848491,
-0.022429895,
0.0066861003,
0.015322025,
-0.019276988,
-0.035677638,
-0.045938417,
-0.0076333554,
0.0024338234,
0.0544568,
-0.009348094,
-0.017465448,
0.03614781,
0.019664187,
-0.017935619,
0.0028262082,
-0.05039121,
0.0078476975,
0.00205181,
-0.0056800735,
0.0039445916,
-0.008165754,
0.005818359,
0.006406072,
0.014395513,
0.0077094124,
-0.03064405,
-0.012922772,
0.015280539,
-0.0013906327,
0.0076886695,
0.018792989,
0.043034423,
0.022015039,
-0.012749916,
-0.0026982944,
0.010087921,
0.017230364,
-0.011505347,
0.002623966,
-0.0066204146,
0.014215741,
0.03614781,
-0.021019384,
-0.015557109,
-0.0019480959,
-0.010613406,
0.01887596,
-0.014049799,
0.0055003027,
0.025167946,
0.0004472669,
0.0023370236,
0.0027536084,
-0.014575283,
-0.008145011,
0.016068766,
-0.031114219,
-0.002459752,
0.045855444,
0.00050085253,
0.016276194,
-0.010274607,
-0.0040655914,
0.0009533051,
-0.00080508046,
-0.004234991,
0.0013344543,
-0.014561455,
-0.02162784,
-0.01696762,
0.03623078,
-0.0063092723,
-0.023577664,
-0.0145476265,
0.014271055,
-0.021309784,
-0.033824615,
-0.03719878,
0.010371407,
-0.030229192,
-0.012812144,
0.017659048,
0.023743607,
0.0014027327,
0.020065214,
0.001330133,
0.014326369,
0.006921185,
-0.012231345,
0.005230646,
0.0056662452,
-0.039687917,
0.0057008164,
0.025624288,
0.02371595,
0.013067972,
-0.018848304,
-0.025831716,
-0.0055279597,
-0.0062885294,
0.018143047,
-0.012348888,
-0.010163979,
0.018654704,
0.0016870821,
0.01906956,
-0.012846716,
-0.015501795,
0.013116372,
-0.021752296,
-0.013157858,
-0.021171497,
0.007826955,
-0.013641857,
-0.012362717,
-0.0052410173,
-0.030339822,
-0.00073723414,
0.01194786,
-0.013551971,
0.011533004,
0.010011865,
0.007419013,
0.041983455,
-0.019871615,
0.018723845,
0.006326558,
0.008200325,
-0.00075149484,
-0.007377527,
0.019221673,
0.0061467867,
-0.0122935735,
0.0054242457,
-0.0056455024,
-0.011698946,
-0.029261194,
-0.006437186,
0.00029061546,
0.050418865,
0.0106894635,
-0.0030941362,
-0.030284507,
-0.018267505,
-0.022651153,
-0.00069834135,
-0.030588735,
-0.017963275,
-0.006371501,
-0.020175843,
-0.0024424663,
-0.025665775,
0.012570145,
-0.020798128,
-0.011408547,
0.040185742,
-0.017133564,
0.012466431,
-0.0018219104,
-0.025292404,
-0.0002499941,
-0.017479276,
-0.027823027,
-0.02067367,
-0.0083316965,
-0.0050958176,
0.038471006,
0.017188877,
0.015515625,
-0.010274607,
-0.011125062,
-0.005884045,
0.0149209965,
-0.008428496,
0.002091567,
0.0027587942,
-0.023978692,
0.01821219,
0.034654327,
-0.01651128,
-0.0062193866,
0.011733518,
-0.0072738132,
-0.00045807046,
-0.0133652855,
-0.020162014,
-0.021959724,
-0.017133564,
-0.009700722,
0.018073905,
-0.014561455,
0.0079030115,
-0.038941175,
0.0013793971,
0.06339004,
-0.01630385,
0.020646013,
0.0016568322,
0.014907168,
-0.020632185,
0.017562248,
-0.011470776,
-0.013372201,
-0.015861338,
0.020244986,
-0.024711605,
-0.012583973,
0.004362905,
-0.0028607796,
-0.013213172,
-0.01081392,
-0.0007264306,
0.010074093,
0.002359495,
0.012597802,
0.0195259,
-0.0055417884,
-0.0066135004,
-0.020604528,
-0.0056593306,
-0.027076285,
-0.04297911,
0.0109038055,
0.007069842,
0.008891753,
0.003007708,
-0.020977898,
-0.014575283,
0.0014182898,
-0.012743002,
0.01868236,
-0.006948842,
0.025596632,
0.03393524,
0.0036783922,
-0.044887446,
0.0045046476,
-0.0056040166,
-0.013828542,
0.032303475,
0.03321616,
-0.021876754,
-0.023231952,
0.055258855,
0.024199948,
-0.0038097634,
-0.008912495,
0.023577664,
0.0014174256,
-0.005911702,
-0.023287265,
-0.032884274,
-0.028030455,
0.026135944,
-0.0055590738,
-0.0008089697,
0.001223826,
0.0020224242,
-0.01489334,
-0.004978275,
-0.022554353,
0.004162391,
-0.01735482,
0.00528596,
-0.00599813,
-0.018267505,
-0.0015315111,
0.008781124,
-0.010343749,
0.03399056,
0.008850267,
-0.0073083844,
-0.000040837414,
0.018060075,
-0.009756036,
-0.002928194,
0.010122493,
0.037281748,
-0.015958138,
-0.005866759,
-0.0049437038,
-0.00027376192,
0.006049987,
-0.013351457,
-0.005797616,
-0.01631768,
0.012321231,
-0.0076886695,
0.02353618,
0.015280539,
-0.023079837,
-0.028348511,
-0.029620737,
0.00985975,
-0.0005466596,
-0.027159257,
0.01189946,
-0.021862924,
-0.010025693,
-0.00014930504,
-0.032884274,
0.012418031,
0.015142254,
0.015045454,
-0.040655915,
0.020521557,
-0.031999245,
0.0017579534,
0.028763367,
-0.0049817325,
-0.008587524,
0.022872409,
-0.013268486,
-0.023840407,
0.0029973364,
-0.03119719,
-0.032303475,
-0.015709223,
0.0011702403,
0.005586731,
-0.01479654,
-0.018336646,
0.019843958,
0.009161409,
0.011864889,
-0.02057687,
-0.012812144,
0.034073528,
-0.026191259,
0.009597008,
0.03197159,
-0.010468206,
0.0048849327,
-0.032967243,
0.024794577,
0.005313617,
-0.024130806,
-0.012272831,
-0.0017890676,
0.007820041,
-0.012424945,
-0.010551178,
0.0052444744,
-0.030561078,
0.0014528612,
-0.0053723888,
-0.0074120983,
-0.009099181,
0.001713875,
-0.00420042,
0.0066549857,
-0.006858957,
0.004639476,
0.0038374204,
0.0034173785,
-0.02360532,
-0.056807652,
-0.0020241528,
-0.014284884,
0.04184517,
0.011470776,
-0.00340355,
-0.010986777,
-0.00422462,
-0.05512057,
-0.012099974,
-0.019221673,
-0.0035504783,
-0.00012175599,
0.014015228,
0.03169502,
0.00422462,
0.011906375,
-0.0022454094,
-0.028376168,
-0.023550007,
0.013697171,
-0.013731742,
0.029897308,
0.0062850723,
-0.043338653,
-0.009873579,
0.03548404,
-0.009555522,
0.0040033627,
0.026606115,
-0.007930669,
0.003571221,
-0.0036922207,
0.017410135,
0.0044769906,
-0.018710017,
0.002999065,
0.000005715752,
-0.011871804,
0.0028037368,
0.0065443576,
-0.0035124498,
-0.0144369975,
0.018958932,
-0.001275683,
0.01147769,
-0.01622088,
-0.017479276,
-0.0012143188,
-0.017935619,
0.007017985,
-0.008801867,
0.023923378,
0.0050301324,
-0.015197568,
-0.021862924,
-0.017659048,
-0.00057431665,
-0.01613791,
0.018129218,
0.012473345,
0.02912291,
0.011844146,
-0.006578929,
-0.006319644,
-0.0019809387,
-0.003007708,
-0.00016421394,
-0.011187291,
-0.024822233,
0.015418825,
-0.0007415556,
0.0066688145,
-0.0013266758,
0.0069281,
-0.00075970555,
-0.0051373034,
-0.004438962,
0.002819294,
-0.0272284,
0.019705672,
0.021600183,
-0.019595044,
0.01275683,
-0.013192429,
-0.0125632305,
-0.013033401,
0.026536971,
0.17556717,
-0.0014191541,
0.03935603,
0.043421622,
-0.0141189415,
0.020175843,
0.020272642,
-0.00015470681,
0.008345525,
0.031114219,
0.0059808446,
0.006018873,
-0.008227983,
0.0053965887,
0.0071078707,
0.009555522,
-0.016552765,
-0.011615976,
0.0068209283,
0.01641448,
-0.0026377945,
0.0065236147,
0.008566782,
-0.009272037,
0.026039144,
0.013448257,
-0.011422376,
-0.0013137115,
-0.011373976,
-0.004231534,
-0.008788038,
0.002447652,
0.0043801907,
0.00410362,
0.0035003498,
0.003534921,
-0.0061156726,
-0.00341565,
0.0062055583,
0.02104704,
0.01792179,
0.0083316965,
-0.01725802,
-0.011982432,
-0.023066008,
0.019415272,
0.0007571127,
0.005313617,
0.014561455,
-0.0017856105,
-0.031805646,
-0.006896985,
-0.014589112,
0.011837232,
-0.003747535,
0.0027363228,
0.041872825,
-0.019152531,
0.0066204146,
0.019401444,
-0.015446481,
0.016054938,
-0.014340198,
0.0056662452,
-0.01508694,
0.031086562,
-0.034958553,
0.0038996488,
-0.01185106,
-0.00069574855,
-0.008705067,
-0.025665775,
-0.00929278,
0.021669326,
-0.013538143,
-0.020424757,
0.010952205,
0.007833869,
0.03706049,
-0.0041209054,
-0.010993691,
-0.0089747235,
-0.026689086,
0.022374582,
-0.016538937,
-0.031280164,
0.034543697,
0.0007480377,
-0.025098804,
0.014616769,
-0.010302264,
0.0045945332,
-0.009382666,
-0.026578458,
0.019194016,
-0.0047293613,
-0.0036853065,
0.013247743,
-0.004335248,
0.00343985,
-0.036756266,
0.056226853,
0.009804436,
-0.0019619244,
-0.0037890205,
0.014042884,
0.0064890436,
0.0057457592,
-0.0006935878,
0.002831394,
0.027767712,
-0.034792613,
0.019498244,
-0.01735482,
0.0040690484,
-0.013752485,
0.017562248,
-0.037890207,
0.022084182,
0.00547956,
-0.006786357,
-0.015778366,
-0.006385329,
0.020632185,
-0.029565424,
-0.013897684,
-0.04438962,
0.01601345,
0.0016862178,
-0.03603718,
-0.0020932956,
-0.021807611,
-0.0058529302,
-0.02200121,
-0.02931651,
0.0022799808,
0.0100464355,
-0.009942722,
0.0061709867,
-0.013399857,
0.030754678,
-0.011284091,
0.021157669,
-0.013054144,
-0.015252882,
-0.0015729966,
0.007578041,
0.013026487,
0.0034623211,
-0.024697777,
-0.02096407,
-0.03119719,
0.011401633,
-0.028569767,
0.03966026,
-0.024144635,
-0.008947067,
-0.02012053,
0.023978692,
-0.00055357383,
-0.014685912,
0.004753561,
0.026052974,
-0.0051338463,
-0.012390373,
0.003178836,
-0.17733723,
0.019415272,
0.036839236,
-0.01696762,
0.03368633,
0.013372201,
0.018156875,
-0.012604716,
-0.0014770612,
0.0016153465,
0.006198644,
0.028597426,
-0.028154911,
-0.016455965,
-0.002419995,
0.014271055,
-0.010730948,
0.025762575,
0.0326077,
-0.009942722,
0.03573295,
-0.012798316,
0.008345525,
-0.02379892,
-0.00010463237,
0.011401633,
-0.020369442,
-0.012570145,
0.0064164437,
-0.021890583,
-0.004283391,
0.0106894635,
0.043864135,
-0.02295538,
0.016068766,
-0.008048211,
0.011367061,
0.015363511,
-0.008684324,
0.020258814,
0.025015833,
0.014658255,
-0.0033655213,
0.0110628335,
-0.0057319305,
0.016248537,
-0.0032376074,
0.00540696,
0.008297125,
0.002819294,
-0.0051926174,
-0.007425927,
0.021378927,
0.0030388222,
0.028818682,
-0.0077024978,
-0.01295043,
-0.009928893,
0.011636718,
-0.00056913093,
-0.015322025,
-0.020728985,
0.023729779,
-0.009348094,
0.021489555,
-0.033243816,
-0.001083812,
0.017659048,
-0.00027419406,
0.010592664,
-0.036673293,
0.01086232,
0.0128328875,
-0.001415697,
0.020300299,
0.013330715,
-0.0012653116,
0.010094835,
0.006250501,
-0.010246949,
-0.04145797,
0.032745987,
0.0027968227,
-0.00538276,
0.009382666,
0.00038611883,
0.010454378,
-0.002903994,
0.0077163265,
-0.004418219,
0.022637323,
-0.024600977,
-0.0056282165,
-0.040545285,
0.016068766,
0.0149763115,
0.015418825,
-0.003778649,
0.016027281,
0.009624666,
-0.00046325615,
-0.018156875,
-0.01062032,
0.014755054,
0.00963158,
-0.01413277,
-0.014022142,
0.009576266,
0.023467036,
-0.0023283807,
-0.008165754,
0.005209903,
0.0044078478,
0.013980656,
0.0030682078,
-0.00858061,
0.0038685347,
-0.007094042,
0.02551366,
-0.036562666,
0.022886237,
0.0048330757,
-0.022720294,
-0.0035504783,
-0.004642933,
-0.0051926174,
-0.11726604,
0.007439756,
0.025527488,
-0.0033983642,
-0.016566593,
0.01630385,
-0.003206493,
0.022319267,
-0.0030699363,
0.024725433,
-0.021185327,
0.013123286,
-0.022941552,
0.016538937,
0.018267505,
0.00040902235,
0.017050592,
-0.014616769,
-0.009686894,
0.027062457,
0.01735482,
-0.026398687,
-0.015792195,
-0.0023283807,
-0.00266718,
0.010834663,
-0.02314898,
0.035871238,
-0.002419995,
0.02436589,
0.016939964,
-0.005299789,
-0.0001744773,
-0.02096407,
-0.031418446,
-0.012680773,
-0.020922584,
0.0005950595,
0.02455949,
-0.037862547,
0.0033810786,
0.0059324447,
0.029427137,
-0.018627046,
0.025582803,
-0.012964258,
0.011318661,
0.003486521,
0.008366268,
-0.021959724,
-0.033658672,
-0.01887596,
-0.009921979,
-0.010772434,
0.0070283567,
-0.012176031,
0.004314505,
0.03661798,
-0.018627046,
-0.006475215,
-0.0076955836,
-0.0044285906,
-0.02446269,
0.024158463,
-0.0031166077,
-0.0045219334,
-0.007474327,
-0.015543281,
-0.0023335665,
-0.024435034,
-0.017783506,
0.019843958,
-0.003223779,
-0.0005315346,
-0.033077873,
0.013503571,
-0.0067275856,
0.008781124,
-0.0014658255,
-0.015806023,
-0.00811044,
-0.011125062,
0.011152719,
-0.029344166,
0.012819058,
0.0070767566,
0.011809575,
0.0035089925,
0.0030128935,
0.009327352,
-0.011159633,
0.0055417884,
-0.018419618,
-0.014409341,
0.015156082,
0.0333821,
-0.015888995,
-0.017672876,
0.03927306,
0.01792179,
-0.030035593,
-0.0061087585,
-0.06610043,
0.007626441,
0.028403826,
-0.012348888,
-0.01285363,
-0.009175237,
0.027062457,
0.008698153,
0.0062021012,
-0.0004228509,
-0.031750333,
0.011021348,
-0.015640082,
0.018461104,
-0.022402238,
-0.008988553,
0.008463068,
0.007045642,
0.017465448,
0.01594431,
0.010267693,
-0.0026205087,
-0.006896985,
0.0055487026,
-0.005223732,
0.00811044,
0.01398757,
0.021406583,
-0.01916636,
0.0036265352,
0.0024770375,
-0.014423169,
-0.019152531,
-0.0032255074,
-0.03379696,
-0.022817094,
0.015073111,
0.02760177,
0.019857787,
-0.0029575794,
-0.02104704,
-0.0100464355,
0.0006045666,
-0.025748745,
-0.008649753,
0.002867694,
0.006838214,
0.02617743,
-0.021074697,
-0.0039411345,
0.05122092,
0.006789814,
-0.015888995,
-0.019373788,
-0.006997242,
-0.010191635,
0.01764522,
-0.011069748,
0.0006853771,
-0.013980656,
0.02768474,
0.0077232406,
0.008214154,
0.020922584,
-0.018834474,
-0.029841993,
-0.029095253,
0.00062574155,
-0.006914271,
-0.016469793,
-0.025029661,
-0.026979486,
-0.014042884,
-0.009700722,
0.00076878053,
0.0023093666,
0.0021935524,
0.017327163,
0.003571221,
0.022637323,
0.009119923,
-0.010530435,
-0.039964486,
0.0034294785,
0.017935619,
-0.005586731,
-0.0036403637,
0.02361915,
-0.01604111,
0.0025012374,
-0.0063369293,
0.013994484,
-0.0075849555,
-0.01076552,
-0.026716743,
0.016151737,
0.024863718,
0.013482829,
0.0032376074,
0.042370655,
0.0117611755,
-0.0062885294,
0.013911514,
-0.05072309,
0.0008928052,
0.019968415,
-0.025970003,
-0.031612046,
0.008933238,
0.0033499643,
0.0071839276,
-0.0005401774,
0.0055487026,
-0.0050232178,
0.0051580463,
0.020397099,
-0.0077785547,
-0.014589112,
-0.03545638,
0.02086727,
-0.0029523938,
0.028763367,
0.0040275627,
-0.018336646,
-0.027864512,
0.003111422,
0.013012658,
-0.0005924666,
0.036369067,
-0.021586355,
-0.0011667833,
0.023591492,
-0.042702537,
-0.02494669,
0.0019740243,
-0.03213753,
0.034681983,
0.0009852836,
0.010115579,
0.08286063,
0.012424945,
-0.018322818,
0.01389077,
-0.035898894,
0.00050042034,
0.0013309972,
0.016372994,
0.0013672971,
-0.028680395,
0.013863114,
-0.009894322,
0.02731137,
-0.034543697,
-0.053820685,
0.01489334,
-0.037807234,
0.025002005,
-0.037392378,
-0.018253675,
0.034101184,
0.013289229,
0.011325576,
0.0013966827,
-0.03612015,
-0.01983013,
0.01499014,
-0.02590086,
0.00052894175,
-0.03169502,
0.00592553,
0.02305218,
-0.015584767,
-0.014153513,
0.01840579,
-0.0046256473,
0.0032721788,
-0.008525296,
0.014865682,
0.0025392661,
0.018322818,
0.021876754,
-0.021365097,
-0.019871615,
-0.00754347,
-0.00820724,
-0.026135944,
-0.014810368,
-0.03545638
] |
Neutrophil apoptosis is a highly regulated process essential for inflammation resolution, the molecular mechanisms of which are only partially elucidated. In this study, we describe a survival pathway controlled by proliferating cell nuclear antigen (PCNA), a nuclear factor involved in DNA replication and repairing of proliferating cells. We show that mature neutrophils, despite their inability to proliferate, express high levels of PCNA exclusively in their cytosol and constitutively associated with procaspases, presumably to prevent their activation. Notably, cytosolic PCNA abundance decreased during apoptosis, and increased during in vitro and in vivo exposure to the survival
|
[
-0.00827327,
-0.014015266,
0.009219168,
-0.017199343,
-0.0367168,
0.010951092,
-0.010538095,
0.020236872,
-0.02214199,
-0.012842886,
0.017039472,
-0.0023464246,
0.014534843,
0.019757261,
-0.003437204,
-0.0070209554,
0.034505267,
-0.016839635,
-0.014281716,
0.018877978,
-0.022821436,
0.025406001,
-0.003660356,
-0.016946215,
0.003580421,
0.017758887,
0.0034105591,
-0.03954117,
0.017439147,
-0.024073752,
-0.0054189255,
-0.010797883,
-0.007673758,
-0.009838664,
0.0032956526,
0.0000048755915,
0.017585695,
-0.01243655,
0.009518923,
0.013036063,
0.0125164855,
-0.014934518,
0.0035504452,
0.012789597,
-0.011723797,
-0.008559704,
-0.0046229064,
0.016426638,
-0.020876352,
0.005545489,
0.033865787,
-0.010384886,
-0.020090325,
-0.006504709,
-0.0039667734,
-0.021262703,
-0.016320057,
0.021475865,
-0.020689838,
-0.012789597,
-0.00997855,
0.00011095141,
-0.023647431,
0.020942964,
-0.0009983545,
0.0010849508,
0.009219168,
0.018744752,
0.013655559,
0.006388137,
0.036317125,
0.029575942,
-0.0048960173,
0.008892766,
0.008353205,
-0.011250848,
-0.010777899,
0.005325668,
-0.014028588,
0.013815429,
0.022861404,
-0.026924765,
0.016879603,
0.0114839915,
0.023793979,
-0.022714857,
-0.029762456,
-0.002924288,
0.019171072,
-0.013322496,
0.019610714,
0.02668496,
0.021462541,
0.018451657,
-0.017519083,
0.02711128,
0.0071275355,
0.007840289,
0.0010624691,
-0.027950598,
-0.014374973,
0.0024430128,
0.0015337524,
-0.007920224,
-0.012216729,
-0.014414941,
-0.002069983,
-0.0018984558,
0.021928828,
0.0028610062,
-0.0046229064,
0.03645035,
-0.01089114,
-0.04852053,
0.040047426,
-0.024060428,
0.028856527,
-0.006441427,
-0.023793979,
-0.013668881,
0.0022265222,
0.032853276,
0.036423706,
-0.022541665,
0.014028588,
0.013975299,
-0.0015204299,
0.0033755875,
-0.020103646,
0.01334248,
0.008832815,
0.020623224,
0.016160188,
0.007860273,
-0.008759541,
0.011004382,
-0.0073406952,
-0.014268394,
-0.027604213,
-0.021755636,
0.02071648,
0.04300502,
0.0016228466,
-0.005468885,
0.009159217,
0.014801294,
0.020823061,
0.020410065,
0.013935331,
0.017812178,
-0.0030541823,
-0.01947749,
0.027124602,
-0.045483,
-0.015121033,
0.014148491,
0.008513075,
0.034984875,
-0.015520709,
-0.0148679055,
0.0023664085,
-0.004975952,
0.02242176,
-0.02038342,
0.006174977,
0.027684147,
-0.005102516,
0.012703001,
0.0050192503,
-0.029336138,
-0.004499673,
0.01766563,
-0.010245,
0.01793208,
-0.013722171,
0.0058585675,
0.00077561906,
0.014628101,
-0.015467418,
-0.01195028,
0.00065030437,
0.005322337,
0.007920224,
-0.012996095,
-0.007327373,
0.013096014,
0.029842392,
-0.017732242,
-0.009239151,
0.02043671,
-0.014255071,
0.0068211183,
-0.009006008,
-0.016320057,
-0.63095343,
-0.02684483,
0.009838664,
0.006421443,
-0.010484804,
0.037729308,
-0.006398129,
-0.04492346,
-0.033332884,
0.02423362,
-0.019570747,
0.0025362703,
0.0038069033,
-0.010644674,
-0.011217542,
-0.030375293,
-0.010438176,
-0.007200809,
0.023474239,
-0.010871157,
-0.007600484,
-0.015014454,
-0.012503163,
-0.0011465673,
-0.008526398,
0.034398686,
0.022648243,
-0.013762139,
0.0029492676,
0.04034052,
-0.02251502,
0.0065579987,
-0.013935331,
0.007733709,
0.056807123,
-0.00981868,
0.0027510955,
0.022088699,
0.014601456,
0.02247505,
-0.016932894,
0.0043198196,
0.021329317,
0.005358974,
-0.02071648,
0.015613966,
0.0030325332,
-0.0067445138,
0.0005416427,
0.0060850503,
0.020596579,
0.017785532,
-0.012463195,
0.0115772495,
0.004296505,
0.02412704,
0.020050356,
-0.046761964,
-0.0052723777,
-0.007667097,
0.0064980476,
-0.000008333065,
-0.021928828,
-0.042285603,
-0.016932894,
0.018118596,
-0.021808926,
0.0011340776,
-0.014215103,
0.011124284,
0.0036870008,
0.006158324,
-0.007220793,
0.0064380965,
0.0073073893,
0.013202594,
-0.02283476,
0.01878472,
-0.018518269,
0.006381476,
0.0029442718,
-0.018877978,
-0.018877978,
0.01905117,
0.029709166,
0.013255884,
-0.024073752,
0.02118277,
0.0048660417,
0.00528237,
-0.001512936,
0.005219088,
-0.012643049,
-0.029336138,
-0.01798537,
0.022022087,
-0.0072607603,
-0.01867814,
-0.011177574,
-0.037676018,
-0.0031091375,
-0.017012827,
0.013975299,
0.015254258,
0.01963736,
0.015161001,
-0.013828752,
0.007993498,
0.030188777,
-0.026591703,
0.013002756,
0.010864495,
0.0015121034,
-0.023554174,
0.0030042229,
-0.01734589,
0.016666442,
0.037915826,
-0.012523146,
-0.023327691,
0.01718602,
-0.018691462,
-0.000621994,
-0.020476677,
0.024513394,
0.006444758,
0.0002822704,
-0.022261892,
0.00150794,
-0.026445156,
0.00037032377,
-0.015707223,
0.012922822,
-0.01617351,
0.018451657,
0.006704546,
-0.0010291628,
0.0028726633,
0.022941338,
-0.03309308,
-0.026565058,
-0.0001659067,
0.009099265,
0.0019084476,
-0.0050825323,
-0.006068397,
-0.019437522,
-0.0061450014,
0.00087012554,
0.02412704,
0.008246625,
0.012409905,
0.010877818,
0.012949467,
0.009006008,
0.012703001,
-0.012962789,
-0.016879603,
-0.015387483,
-0.021902183,
-0.008146706,
0.016080253,
-0.010264983,
0.0054289172,
-0.007547194,
0.006704546,
0.019970423,
0.0033922407,
0.008839476,
-0.023367658,
0.0017402511,
0.008399834,
-0.02481981,
0.005032573,
0.006914376,
0.0072874054,
-0.01905117,
-0.015174324,
0.005555481,
0.01777221,
0.015267581,
-0.0345852,
0.0065147006,
-0.0009883627,
0.007174164,
0.026165383,
0.03575758,
0.010837851,
-0.003473841,
0.034878295,
0.0018568229,
0.011630539,
-0.027923953,
0.007060923,
-0.008106739,
-0.031414445,
0.0018734761,
0.014654746,
0.02187554,
0.036583576,
-0.020543288,
-0.02246173,
0.022528341,
-0.021422574,
0.018171884,
-0.0062415893,
0.010897802,
-0.017758887,
0.016759701,
0.008053449,
-0.008959379,
0.007940208,
-0.027244505,
-0.015067743,
-0.001696953,
0.005748657,
-0.00046045877,
-0.00037573604,
0.0046595433,
-0.002049999,
0.0019034516,
-0.004689519,
0.0097121,
-0.013935331,
-0.016386671,
0.00469618,
0.01905117,
0.028909817,
-0.015041098,
-0.014321684,
0.0018451657,
0.011557265,
-0.0025312742,
-0.0019034516,
-0.006647926,
0.012476518,
0.013262545,
-0.0006961004,
0.020276839,
0.0078003216,
-0.016106898,
0.005032573,
-0.006068397,
0.016626475,
-0.00880617,
-0.005685375,
0.02663167,
0.022874726,
-0.015147679,
0.0015054421,
-0.0023664085,
0.009345731,
-0.020583257,
0.008213319,
0.0017069449,
-0.0060117766,
0.006954343,
-0.00022419263,
0.056540675,
0.011337444,
0.029789101,
-0.0064380965,
0.0038568627,
-0.019437522,
0.017905435,
-0.021382606,
0.01846498,
-0.020982932,
0.0027610874,
-0.0070476006,
-0.02444678,
-0.008886105,
0.025739063,
-0.02343427,
0.009592197,
-0.018984558,
0.027284473,
0.013602269,
0.010644674,
-0.01878472,
-0.012176761,
-0.029016398,
0.023447594,
0.030641742,
-0.011277493,
-0.013375786,
-0.027137926,
-0.009545568,
-0.0128628705,
0.019650683,
-0.01777221,
0.03677009,
-0.009065959,
0.015787158,
-0.015467418,
-0.012902837,
0.024566684,
-0.027524278,
0.016759701,
-0.0103249345,
0.011530621,
-0.021289349,
-0.0038668546,
-0.003457188,
0.021222737,
-0.0022298528,
0.005791955,
-0.016999505,
-0.019450845,
-0.017838823,
-0.027417697,
-0.0018701454,
0.023287723,
-0.0023097878,
-0.008619655,
-0.018704785,
0.014441586,
0.007767015,
0.013762139,
0.00912591,
-0.0005441407,
-0.021609088,
-0.0050292425,
-0.013509011,
0.01979723,
0.024739876,
0.003190738,
0.013429076,
-0.0074472753,
-0.0060384213,
0.003960112,
-0.0014055234,
0.043431338,
-0.015973672,
-0.007540533,
0.02390056,
0.009931921,
0.0051324917,
0.027137926,
0.037382923,
0.012483179,
0.0024679925,
-0.031147996,
-0.005112508,
0.012536469,
-0.01125751,
0.03266676,
0.03650364,
0.026565058,
0.017319245,
0.014708036,
-0.0050725406,
0.010624691,
-0.011204219,
-0.00001347862,
0.013309174,
0.0146813905,
-0.0027261158,
-0.014734681,
-0.009705438,
0.0079135625,
0.035944097,
0.00092508085,
-0.00597514,
0.010411531,
-0.0010058485,
0.010684642,
-0.011890328,
0.013435737,
-0.00218822,
0.02049,
0.017918758,
-0.01590706,
-0.023247756,
0.029629232,
-0.020649869,
-0.02251502,
-0.01910446,
0.005385619,
-0.00875288,
0.0079135625,
0.003127456,
0.0081134,
-0.0055987793,
-0.00843314,
-0.0029076347,
0.029442716,
-0.016053608,
0.0013414088,
-0.014095201,
-0.018238498,
-0.019917132,
-0.043937594,
-0.023101209,
0.013788784,
-0.039461233,
-0.032107215,
0.01665312,
0.018291788,
0.02561916,
0.026605025,
-0.011270832,
-0.03708983,
0.032879923,
0.0060384213,
-0.025912255,
0.00469618,
-0.04910672,
0.022435084,
-0.0038868382,
-0.017452471,
-0.012836225,
-0.033119727,
0.002875994,
0.0162268,
-0.01142404,
-0.0005970144,
0.00997855,
-0.023634108,
0.025259454,
0.01979723,
0.024060428,
0.0028476836,
0.003224044,
0.0053889495,
-0.04569616,
-0.028643368,
-0.0361839,
-0.022821436,
-0.03394572,
-0.006714538,
0.017958725,
-0.0018318433,
-0.010178387,
0.010611368,
-0.006488056,
-0.016439961,
-0.008732896,
-0.0011274163,
0.04209909,
0.0017219327,
0.027870663,
0.010344919,
0.0028593407,
-0.0098852925,
-0.005875221,
0.021515831,
0.013162626,
-0.007274083,
0.0028110468,
-0.01633338,
-0.0014796298,
-0.0024713231,
0.008386511,
-0.020423386,
0.012163439,
-0.0002464662,
-0.03256018,
-0.017532405,
-0.012150116,
-0.0019817213,
0.021102834,
0.011430702,
-0.029789101,
0.004136635,
-0.009512262,
-0.0038701852,
-0.0029975616,
0.023141176,
-0.027364407,
-0.000442973,
0.011930295,
0.010225016,
-0.0129561275,
-0.018211853,
-0.0026178705,
0.00022564978,
0.0028210387,
-0.03373256,
-0.03820892,
0.029282847,
-0.012363276,
0.03874182,
0.02529942,
0.017479114,
-0.0031441092,
0.0027943936,
0.02695141,
-0.0052224183,
-0.004552963,
-0.016986182,
0.0053989417,
-0.01814524,
0.027137926,
0.00629821,
0.003650364,
0.0027677487,
-0.024366846,
0.015280903,
0.017092763,
0.000050844057,
-0.030801611,
-0.007866934,
-0.03181412,
-0.019770585,
0.0033972366,
-0.028163757,
0.0006448921,
-0.016573185,
0.003976765,
-0.0036703476,
0.016439961,
0.004099998,
-0.0038135645,
0.014414941,
-0.0133025125,
0.0015570668,
-0.007054262,
0.007767015,
-0.003292322,
-0.0071475194,
0.00016798836,
0.015867094,
0.0062915487,
0.0066046277,
0.014015266,
-0.000024081974,
-0.0143350065,
-0.01307603,
0.0026778218,
-0.025925579,
-0.06464075,
-0.00192177,
-0.00437644,
-0.021355962,
0.0041599493,
-0.0018101942,
-0.023754012,
0.018118596,
0.0032523545,
-0.0028310304,
0.0042665293,
0.006035091,
-0.017585695,
0.02352753,
-0.009685455,
-0.0069943108,
-0.038981624,
0.029842392,
0.0015945362,
-0.0038468707,
-0.030828256,
-0.024766522,
-0.010504789,
0.01814524,
0.044870168,
0.031840768,
-0.018291788,
-0.011763765,
-0.015254258,
0.0022015425,
0.0083198985,
-0.020250194,
0.03858195,
-0.000864297,
0.02316782,
-0.011677168,
-0.012143455,
-0.03714312,
0.008926072,
-0.010711287,
0.0047361474,
0.020343453,
-0.012643049,
-0.019544102,
0.011330783,
-0.015707223,
0.014255071,
-0.0049426463,
-0.02390056,
-0.002834361,
0.0034038979,
-0.00049251603,
-0.010011856,
-0.013202594,
0.025605839,
0.010611368,
0.0020316807,
0.013655559,
0.021795604,
-0.0032190483,
-0.0049026785,
0.010378225,
0.038502015,
0.0075272103,
-0.004226562,
0.025326066,
0.02412704,
0.0130493855,
-0.029895682,
-0.016892925,
-0.024699908,
-0.013115997,
-0.0071275355,
0.015760513,
0.0070476006,
-0.013369125,
-0.0030058883,
-0.015440773,
0.0026228665,
-0.022221925,
0.0050292425,
-0.00036678498,
-0.029176267,
-0.031041417,
0.01355564,
0.01878472,
0.007507227,
0.00234809,
0.019237684,
-0.032826632,
0.023367658,
-0.008546381,
0.025272775,
-0.004456375,
-0.0048327358,
-0.00012406574,
0.009119249,
-0.0019300967,
-0.013975299,
0.013868718,
-0.016573185,
-0.025432646,
0.002822704,
-0.025898933,
0.042285603,
0.019930454,
-0.025312742,
0.007400647,
0.031547673,
0.0003341032,
0.0012797923,
0.009405683,
0.018811366,
-0.014894551,
0.009245813,
0.021342639,
-0.00037386257,
-0.029202912,
0.00023002122,
-0.0106047075,
0.026471801,
-0.0014688052,
-0.026271963,
-0.018291788,
0.0022048731,
0.0038335484,
-0.021982118,
-0.014388296,
-0.0000823809,
-0.011563927,
-0.000675284,
0.004419738,
-0.009105926,
-0.0015595647,
0.01915775,
-0.011237525,
0.0074539366,
-0.02219528,
0.00013260047,
-0.002631193,
-0.056966994,
-0.013562301,
-0.0043364726,
-0.035411194,
0.028003886,
0.021995442,
-0.0027077973,
-0.016826313,
0.0061250175,
-0.046095837,
-0.010018517,
-0.024353523,
0.008299915,
0.0033006484,
0.010851174,
-0.015587321,
0.010398208,
-0.0041599493,
0.011970263,
-0.00055954483,
-0.030428581,
0.01819853,
-0.015720546,
0.017758887,
-0.023887236,
-0.012643049,
-0.019863842,
0.012050197,
-0.0044330605,
-0.03410559,
0.0014146826,
0.002353086,
0.019251008,
-0.013828752,
0.002406376,
0.009065959,
0.00827327,
0.009738745,
-0.019983744,
-0.009432327,
0.016879603,
-0.0013414088,
-0.025232809,
0.009412344,
0.010931108,
0.0035038164,
-0.017252633,
-0.024433458,
-0.046149127,
-0.0011848696,
-0.020130292,
0.029948972,
0.02112948,
-0.017838823,
0.034771714,
-0.014361651,
-0.02242176,
-0.020929642,
-0.023620786,
-0.020077001,
-0.020196903,
0.0066779014,
0.009192523,
-0.010051823,
-0.009632165,
0.023154499,
-0.017892113,
-0.016000317,
-0.012056859,
0.0011915307,
-0.03394572,
0.0057020285,
0.01899788,
0.027630858,
0.0037236377,
-0.0034505266,
-0.021928828,
-0.0052490635,
-0.0007135862,
-0.018691462,
-0.0070476006,
0.0009583871,
-0.0017385858,
0.0028260346,
0.011117623,
-0.0018601535,
-0.021435896,
0.011943618,
0.021888861,
0.19013867,
-0.025739063,
-0.0031407785,
0.0033789182,
-0.005245733,
0.005112508,
-0.0049659605,
-0.016093576,
-0.009272457,
0.0071541807,
0.012183423,
0.014721358,
-0.0065080393,
-0.00021440892,
0.028403562,
-0.016506573,
-0.013682203,
-0.0011315795,
-0.034292106,
-0.0010366568,
0.015733868,
-0.014721358,
0.019863842,
0.023740688,
0.03868853,
0.004872703,
-0.021795604,
0.012190084,
0.016852958,
-0.0038668546,
-0.028989753,
0.009905276,
0.013322496,
-0.00020191909,
0.0137088485,
-0.0024263596,
-0.015454096,
-0.014907873,
-0.003222379,
-0.013462382,
-0.010931108,
0.010957753,
-0.0062782266,
0.016506573,
-0.010158404,
0.019024525,
-0.004526318,
-0.024060428,
-0.0138021065,
-0.0013522333,
-0.04852053,
0.0010774569,
0.011990246,
0.0077004028,
-0.0034838328,
-0.0072940667,
-0.002364743,
-0.0031357827,
-0.0025928908,
0.034345396,
0.0002972582,
0.0052224183,
-0.040420454,
0.027337762,
-0.004626237,
0.012716323,
0.0017835492,
0.00197506,
0.013442399,
-0.028217047,
0.006667909,
0.010931108,
-0.015840448,
-0.0010333261,
-0.016386671,
-0.006954343,
0.007380663,
0.033972364,
0.014668069,
-0.0040700226,
0.027897308,
0.00560544,
-0.04161948,
0.009419004,
0.0074206307,
-0.028616723,
0.0073340344,
0.006954343,
-0.014974486,
-0.027018022,
0.017225988,
-0.0032673422,
-0.019277653,
0.0020799746,
0.024726553,
0.010251661,
-0.005368966,
0.015227613,
-0.021755636,
0.013369125,
-0.034238815,
0.079508655,
0.012623065,
0.012270019,
-0.00528237,
0.01109764,
-0.016000317,
0.018744752,
-0.012230052,
-0.0051624672,
0.023047918,
-0.0043098275,
0.009119249,
-0.019357586,
-0.0078802565,
0.028749947,
-0.015560675,
-0.022994628,
0.04841395,
-0.011464008,
-0.008746219,
-0.039194785,
0.0043531256,
0.021089511,
-0.016053608,
0.004119982,
-0.04617577,
0.012123472,
-0.00891275,
-0.012463195,
-0.00038218912,
0.0056753834,
-0.015067743,
0.005795286,
0.0026495114,
0.01777221,
-0.0003619972,
-0.016133543,
0.0057719713,
0.025046293,
-0.010697965,
-0.00029788268,
0.008459785,
0.005545489,
-0.010691303,
0.009099265,
0.006178308,
0.027097957,
-0.015094388,
-0.025818998,
-0.009991872,
-0.003810234,
-0.011110962,
0.009965227,
0.014708036,
-0.039061558,
-0.019877164,
-0.015867094,
0.0045562936,
-0.0058252616,
-0.032000635,
0.0060284296,
0.014974486,
0.0062882183,
-0.0067012156,
-0.005255725,
-0.16690424,
0.0131759485,
0.016000317,
0.008353205,
0.03964775,
0.021995442,
-0.013722171,
0.014401618,
-0.0068411017,
-0.006201622,
0.028909817,
0.009705438,
-0.03783589,
-0.030908192,
0.010837851,
0.005225749,
0.030615097,
0.049319882,
0.0071208742,
0.016106898,
0.023740688,
-0.018917944,
0.027311118,
-0.00035491964,
-0.01537416,
0.00624492,
-0.0076337904,
-0.007926885,
-0.013575624,
-0.0049826135,
-0.0068177874,
0.0027660832,
0.018118596,
0.012409905,
-0.0032257093,
0.0095722135,
-0.0127696125,
-0.00384354,
0.0020233542,
0.016959539,
0.02033013,
0.0040900065,
-0.0018534923,
0.0047827763,
-0.014654746,
0.025898933,
0.0026128746,
-0.015427451,
0.0238073,
-0.009325747,
0.019530779,
-0.010697965,
-0.011330783,
0.011543943,
0.008506414,
0.010897802,
0.012050197,
0.008679606,
0.008566366,
0.024020461,
0.02444678,
-0.0033705917,
0.033705916,
0.039674394,
-0.005775302,
-0.056007773,
-0.025499258,
0.039248075,
-0.027577568,
-0.0032207135,
-0.011031027,
-0.015680578,
0.030295357,
-0.026498444,
0.045269843,
0.00017902104,
0.0017385858,
0.021609088,
0.0062715653,
0.017599018,
-0.00005396652,
0.016053608,
-0.023927204,
-0.030934837,
-0.002619536,
-0.0045129955,
0.006607958,
0.018291788,
-0.015254258,
-0.0038202258,
0.008140045,
-0.03538455,
0.00859301,
-0.005961817,
0.026165383,
0.017998692,
-0.015161001,
-0.009625504,
-0.023101209,
0.00081974984,
0.015893739,
-0.0029209573,
-0.008892766,
0.0057986164,
0.04279186,
0.0007972681,
-0.006228267,
-0.014348328,
0.029442716,
-0.009752068,
-0.0066512562,
0.018158562,
-0.0014921196,
0.026058802,
-0.0048660417,
0.00056079385,
0.014494876,
-0.014947841,
-0.030162131,
-0.027764082,
0.076151386,
-0.011523959,
-0.0010208363,
0.0130493855,
-0.005775302,
-0.030828256,
-0.14303032,
-0.011843699,
-0.005528836,
0.051478125,
-0.019357586,
-0.0038868382,
0.0006736187,
0.029202912,
-0.017918758,
0.034558557,
-0.011457346,
0.015107711,
-0.0028476836,
-0.0037369602,
0.017159374,
0.00250796,
0.00517579,
-0.01121088,
-0.009612181,
0.02017026,
-0.0011082651,
0.0034038979,
0.00071858213,
-0.018718107,
0.0036203885,
-0.016266769,
-0.012949467,
0.010118436,
0.0021465872,
0.023061242,
0.0009050971,
-0.011823716,
0.032160506,
-0.006934359,
-0.017132731,
-0.012030214,
-0.013855396,
-0.02182225,
0.030908192,
-0.012316648,
-0.008832815,
-0.0030991456,
0.017692275,
-0.0073939855,
0.015161001,
-0.012709661,
-0.0081933355,
-0.005668722,
0.008666283,
-0.025059616,
-0.023327691,
-0.014348328,
-0.015760513,
0.0013622253,
0.0035138084,
-0.01088448,
0.022554986,
0.036903314,
-0.029815746,
-0.0066312724,
-0.0036836702,
0.019197717,
-0.020050356,
-0.003570429,
0.023687398,
-0.0076071452,
-0.020649869,
-0.030668387,
0.0072341156,
-0.01878472,
0.01318261,
0.0016661447,
-0.024273587,
-0.0070276167,
-0.013275867,
0.0008143376,
-0.011617217,
0.011184236,
0.0023464246,
-0.0039567812,
-0.013029401,
-0.015320871,
0.007274083,
0.010078468,
0.019490812,
0.0071541807,
0.029842392,
0.008286593,
0.010231677,
-0.0046761963,
-0.0022781468,
0.03639706,
0.0013214251,
-0.013562301,
-0.016666442,
0.008866121,
0.00010637181,
-0.024167009,
0.008686268,
0.015041098,
-0.0074272915,
-0.0072674216,
-0.054462366,
0.0074206307,
-0.024300233,
0.003980096,
0.020023713,
-0.02017026,
0.009492279,
-0.028536787,
0.0065946355,
0.022075376,
-0.031547673,
0.031147996,
0.004652882,
0.00005037569,
-0.019384231,
-0.0036103965,
0.039780974,
-0.012056859,
0.011590572,
0.0077603543,
-0.009025991,
-0.009618842,
0.028536787,
0.0028776592,
0.0058186003,
-0.014321684,
0.0032806648,
-0.0038801772,
-0.0006153328,
0.0044963425,
-0.006954343,
-0.056380805,
-0.018371722,
-0.007813644,
-0.030508516,
-0.027044667,
-0.014734681,
0.02107619,
0.014894551,
0.032080572,
-0.025645806,
-0.031947345,
0.010384886,
-0.0025645806,
0.012123472,
-0.016773023,
-0.027923953,
0.008972702,
0.009099265,
-0.01590706,
0.045882676,
0.007300728,
0.014881228,
-0.047268216,
-0.027444342,
0.015320871,
-0.010185048,
-0.007080907,
0.010438176,
-0.013762139,
0.01915775,
0.013089352,
0.018558238,
0.020463355,
-0.013189271,
-0.003720307,
-0.0148679055,
0.006501378,
-0.0042398847,
-0.022634922,
0.0011815389,
-0.00074397813,
0.030455226,
-0.012216729,
0.02017026,
-0.0025312742,
-0.022275213,
0.0031391133,
-0.01691957,
0.02172899,
0.01089114,
0.029469362,
-0.026445156,
0.024047107,
0.042578697,
-0.014841261,
-0.012503163,
0.02716457,
0.0014896216,
-0.0022564977,
-0.026711605,
0.018811366,
0.014295039,
-0.003447196,
-0.007853611,
0.020996254,
-0.009472295,
0.014921196,
0.0037702664,
0.029575942,
0.0047361474,
0.007407308,
0.00094839523,
-0.009458972,
-0.0019550764,
0.031467736,
-0.024913069,
-0.017625663,
-0.0057419958,
0.0019334273,
0.021689024,
-0.00024084575,
-0.007946869,
0.010058485,
-0.01350235,
0.027417697,
-0.006687893,
-0.012689678,
-0.010944431,
0.018544914,
0.013682203,
0.026724927,
-0.006847763,
-0.0041899253,
0.0058519067,
0.004016733,
0.0049226624,
-0.018811366,
0.022781469,
-0.024739876,
0.03165425,
-0.020410065,
-0.059578203,
-0.01985052,
-0.013548979,
-0.006751175,
0.021649057,
0.03309308,
-0.016293412,
0.08068104,
0.0069943108,
-0.032320376,
0.0017968717,
0.009139232,
0.009438989,
-0.010171726,
-0.0027827364,
0.016080253,
-0.032773342,
0.013142643,
-0.014255071,
0.025272775,
-0.035890806,
-0.0041932557,
0.029362781,
-0.024646617,
0.007014294,
-0.0024080412,
-0.010424853,
0.013682203,
-0.014827939,
-0.028803237,
0.028616723,
-0.01878472,
0.022541665,
0.014081879,
-0.014734681,
0.016266769,
-0.019517457,
0.0021099504,
-0.014601456,
-0.027657503,
-0.001798537,
0.0009317421,
-0.0016753039,
-0.0060384213,
-0.017572373,
-0.0042332234,
0.026565058,
-0.0074272915,
0.013369125,
-0.0025479274,
-0.032533538,
0.03325295,
0.005565473,
-0.005135822,
0.006974327,
-0.009945244
] |
Almost immediately after a human being is born, so too is a new microbial ecosystem, one that resides in that person's gastrointestinal tract. Although it is a universal and integral part of human biology, the temporal progression of this process, the sources of the microbes that make up the ecosystem, how and why it varies from one infant to another, and how the composition of this ecosystem influences human physiology, development, and disease are still poorly understood. As a step toward systematically investigating these questions, we designed a microarray to detect and quantitate the small subunit ribosomal RNA (SSU rRNA) gene sequences of most currently recognized species and
|
[
0.026616894,
-0.0128150545,
-0.00368071,
-0.029366737,
-0.02797208,
0.007249584,
0.0017087836,
-0.0042168633,
-0.037024193,
-0.0013864336,
0.0075390413,
-0.027551051,
-0.011045419,
-0.016156968,
0.006417395,
0.01067044,
0.035918992,
0.005414163,
0.005433899,
0.013025569,
-0.021748753,
0.021564553,
-0.000023024995,
-0.018959438,
0.008624505,
0.03541902,
0.025814308,
-0.028366795,
-0.009512613,
-0.005318774,
0.0047003883,
-0.0074732555,
-0.017722668,
-0.018143697,
-0.018051596,
-0.007433784,
0.0062989807,
0.008117955,
-0.0056016524,
-0.004512899,
0.02041988,
0.018433154,
-0.017051654,
0.011933526,
0.005999656,
0.012749269,
-0.022117153,
-0.0036313706,
-0.011440134,
0.006170699,
0.01168354,
0.010006005,
-0.031708706,
-0.0044109314,
-0.018196324,
0.0103744045,
-0.014946511,
-0.0140649825,
0.0025376834,
-0.004348435,
-0.00042308428,
0.0056838845,
-0.030208794,
-0.0040260847,
-0.019840967,
0.002708726,
-0.006371345,
0.010683598,
0.0016051711,
0.025590638,
0.029840393,
0.011025683,
0.009742863,
0.012663747,
0.02677478,
-0.012071676,
-0.028235223,
-0.010058634,
-0.00036901666,
0.010367827,
0.003565585,
-0.020183053,
0.0009818516,
0.0061838557,
-0.0033271117,
-0.012242719,
0.013828154,
0.014420225,
0.009321834,
0.0012408828,
0.010637548,
0.027629994,
0.016827982,
0.024945937,
-0.017117439,
0.012920312,
-0.03602425,
0.04223442,
0.006213459,
-0.042523876,
-0.024511753,
0.023024995,
0.0005176512,
-0.011788798,
-0.012722954,
0.011262512,
0.014486011,
-0.014670211,
0.004318831,
-0.016249068,
-0.014880725,
0.023511808,
-0.018393682,
-0.019748867,
0.014788626,
0.01071649,
0.038576733,
-0.00345046,
0.011104627,
-0.006361477,
0.012380869,
0.009144212,
0.005664149,
-0.009913905,
0.03226131,
0.018406838,
-0.027735252,
0.007512727,
0.004282649,
-0.019012067,
-0.008348205,
-0.0065719914,
0.005779274,
0.029156223,
-0.013413704,
0.013466333,
-0.022788167,
-0.003164292,
-0.01067044,
-0.01918311,
0.02999828,
0.017577939,
-0.033471763,
-0.0050819456,
0.023603909,
0.017551625,
0.020340938,
0.023722323,
0.0026626762,
0.00038155707,
0.021380352,
-0.028945709,
0.0022054657,
-0.02884045,
0.00911132,
0.022380294,
0.0002715716,
0.032234993,
-0.023222351,
-0.012755848,
-0.0026922799,
-0.010828326,
-0.0000929223,
0.013512383,
0.016867453,
0.026919508,
0.019156795,
-0.0035392707,
0.020604081,
0.0034570384,
-0.013466333,
-0.0018370657,
-0.028235223,
-0.0027218834,
-0.0037991242,
0.014486011,
-0.01320319,
0.025222238,
-0.025235394,
-0.03473485,
-0.00037970685,
0.0030442332,
0.01734111,
0.008367941,
-0.022485552,
-0.021275096,
0.02102511,
0.036287393,
0.034655906,
0.007946912,
-0.016196439,
0.014025511,
0.008992905,
0.01251244,
-0.6593306,
-0.013854468,
-0.0015007363,
-0.010927005,
0.002966935,
-0.0069995984,
-0.00094978104,
-0.0031741601,
0.021354038,
0.028945709,
-0.015341225,
0.0142360255,
0.024959095,
-0.019406782,
-0.013262398,
-0.022248724,
0.0060753096,
-0.02520908,
0.008986327,
-0.021617182,
-0.03276128,
0.009506034,
0.007854813,
0.01669641,
0.0005073722,
0.015564897,
0.020722495,
0.006473313,
-0.018525254,
0.023301296,
-0.0112822475,
0.02295921,
-0.009624448,
0.012801898,
0.048339333,
-0.034261193,
-0.028498365,
0.02419598,
0.0012104568,
0.008071905,
-0.0026149815,
-0.023024995,
0.010604654,
-0.0016035264,
0.0038057028,
0.026551109,
0.014314968,
-0.002925819,
0.0011578284,
0.0044010635,
-0.0020738943,
0.013814997,
0.00025471402,
0.010407298,
0.032208677,
-0.0017334532,
0.013907097,
-0.020761967,
0.0055029737,
0.011762483,
-0.0019308103,
-0.0035918993,
-0.0016512211,
-0.015709626,
-0.025630109,
0.026301123,
-0.038760934,
0.003855042,
0.019354153,
-0.016064867,
0.015906982,
0.03602425,
0.00708512,
-0.028577307,
0.0022630282,
0.027024766,
-0.015538583,
0.0044109314,
-0.007742977,
0.005654281,
-0.0017745693,
0.019077852,
-0.021156682,
0.0019883728,
0.007650877,
-0.00368071,
-0.01638064,
0.0091771055,
-0.024577538,
-0.015801726,
-0.002360062,
0.015696468,
-0.012670326,
-0.021275096,
-0.01632801,
0.024472281,
-0.011071733,
0.0046082884,
0.026156394,
-0.0119072115,
-0.015999082,
-0.004440535,
-0.000009308934,
0.013032148,
0.029603565,
-0.0028879922,
-0.026630051,
0.0016684898,
0.03252445,
-0.042313363,
0.020222524,
0.020551452,
-0.016262226,
0.009124476,
-0.010407298,
-0.023248667,
0.009163948,
0.015420168,
-0.0056608594,
-0.037655734,
0.008124534,
0.010216519,
-0.00026992694,
-0.00699302,
0.006821977,
0.03362965,
0.0030442332,
0.0023814423,
-0.003565585,
-0.01582804,
-0.009841541,
0.009486298,
0.038866192,
-0.017604254,
0.031682394,
0.020064639,
0.037339963,
0.008335048,
-0.020814596,
-0.029366737,
-0.01982781,
-0.018762082,
0.004884588,
-0.010854641,
-0.007973227,
-0.013236083,
-0.010433612,
-0.009104741,
0.0012433497,
-0.015801726,
0.008117955,
-0.000052885534,
-0.024406495,
0.02976145,
0.01518334,
-0.015893824,
-0.024406495,
-0.04407642,
-0.003762942,
0.008828441,
-0.011769062,
0.01490704,
-0.015485954,
-0.0025639976,
-0.0032037636,
-0.006821977,
-0.033287566,
-0.0137228975,
0.0050358954,
-0.02520908,
0.008979748,
-0.021182995,
-0.019788338,
-0.0017219407,
-0.010466505,
0.01592014,
-0.020117268,
0.01242034,
-0.034945365,
-0.011578283,
-0.017788453,
-0.022064524,
-0.000026596954,
-0.004654338,
0.02028831,
0.015301754,
0.030182479,
-0.023538124,
0.006729877,
0.041708134,
0.005358245,
0.01398604,
-0.016446425,
0.018367367,
0.0026347174,
-0.035866365,
-0.017235853,
0.008492934,
0.013565011,
0.029656194,
0.020551452,
0.0012943336,
-0.001653688,
-0.02834048,
-0.002677478,
-0.033787537,
-0.004884588,
-0.023103938,
0.017446367,
0.008986327,
-0.0017054942,
-0.011828269,
-0.0039767455,
-0.024590695,
0.014985982,
0.015999082,
-0.009216577,
-0.0024505174,
-0.019433096,
-0.02038041,
0.0014719551,
0.00031782716,
0.028129965,
-0.0056378343,
0.00014997085,
0.022367138,
-0.012565069,
-0.011025683,
-0.013828154,
-0.016196439,
0.01352554,
0.01536754,
0.015380696,
-0.003077126,
0.011762483,
0.016854296,
-0.010532291,
-0.02015674,
0.009479719,
0.023393394,
-0.014643897,
-0.0046214457,
0.006404238,
-0.007907441,
0.036866307,
-0.0066772485,
0.016551683,
0.002889637,
-0.029919336,
0.010295462,
-0.007650877,
-0.004973399,
-0.011301983,
0.00040992713,
-0.0007766824,
-0.02028831,
0.008598191,
0.00066978065,
0.02907728,
0.0040425314,
-0.005341799,
0.023748638,
-0.011308562,
-0.034866422,
-0.0033879636,
0.007492991,
-0.01117699,
-0.013578168,
-0.021551395,
-0.004884588,
-0.026511637,
-0.0033139547,
0.0023090781,
-0.00607202,
0.01352554,
0.011354612,
0.020946167,
-0.0022054657,
0.016762197,
-0.0076574553,
-0.0022564495,
-0.006789084,
0.0026495191,
0.051128644,
0.0009506034,
-0.0040227957,
-0.022656595,
-0.01955151,
0.000724465,
0.005318774,
0.0068351342,
0.0137228975,
0.00694697,
0.004512899,
-0.009381041,
-0.00018923669,
0.019512039,
-0.035024308,
0.010532291,
0.009124476,
0.013762369,
-0.01472284,
-0.017406896,
-0.015157025,
0.03389279,
0.012979519,
-0.017577939,
-0.0134400185,
0.00030425887,
-0.011236197,
-0.017933182,
-0.010690176,
-0.013933411,
0.0105980765,
-0.006141095,
0.017183226,
-0.019025225,
0.0038517527,
0.015722781,
-0.0075193057,
0.0020755387,
-0.025353808,
-0.011696697,
0.0068351342,
0.05262856,
0.018762082,
-0.003123176,
0.04420799,
0.0026511636,
0.00069568376,
-0.010157312,
-0.028603623,
0.024353866,
-0.0017910157,
0.002884703,
0.004664206,
0.016775353,
-0.0028353636,
0.009058691,
0.00053080835,
0.007394313,
-0.024761738,
-0.018156853,
-0.0019768602,
0.0067825057,
-0.0031626476,
0.01113094,
0.030471936,
0.0067002736,
-0.0039537204,
0.017472683,
0.012157197,
0.002470253,
-0.026248494,
-0.0072035342,
0.021643495,
-0.020433038,
0.018617352,
-0.00062496413,
0.009650762,
0.021222467,
0.00085603644,
0.017196381,
0.018854182,
0.025643267,
0.023261823,
-0.00340441,
-0.011321719,
0.0065950165,
0.012525598,
-0.0072298483,
0.0026758334,
0.014367597,
-0.03073508,
0.011953262,
0.0038747778,
0.008565298,
-0.022432923,
0.020577768,
-0.0004584441,
0.016946396,
0.01274269,
-0.030077223,
-0.02598535,
-0.009808647,
-0.025590638,
0.017591096,
0.0035228243,
0.007789027,
-0.030340364,
-0.0081574265,
0.0115651265,
-0.037050508,
-0.0037826777,
-0.00009934669,
-0.025840623,
-0.012453233,
0.01324924,
0.014801783,
0.0022202674,
0.006631199,
-0.015578054,
0.00667067,
-0.0015262283,
-0.0059700524,
-0.027156336,
0.031998165,
0.0030672583,
0.010104683,
0.007789027,
0.02566958,
-0.0020442905,
-0.01890681,
0.011828269,
-0.010032319,
0.012999254,
-0.0009834962,
0.0038188598,
-0.009400777,
0.013051883,
0.012597961,
0.021446139,
-0.016064867,
-0.028919393,
-0.022275038,
-0.028235223,
0.011348033,
0.0008511025,
-0.02189348,
-0.017604254,
-0.027024766,
0.0007812052,
-0.020854067,
-0.024998566,
0.008341627,
-0.016406953,
0.013361076,
0.024314394,
0.016406953,
0.02828785,
0.011466447,
0.015446482,
0.015407011,
-0.0067331665,
-0.00680882,
-0.016367482,
0.029024651,
0.016814824,
-0.0010945096,
0.0133281825,
0.009150791,
0.002240003,
-0.042444933,
-0.018880496,
0.0057398025,
0.03247182,
0.011532233,
-0.023722323,
-0.01770951,
-0.015078083,
-0.001881471,
0.01623591,
-0.032208677,
-0.022472395,
0.00007041126,
-0.016564839,
0.0052562775,
-0.013084776,
0.021696124,
-0.026366908,
0.0060522845,
0.01186774,
-0.0039109597,
0.029050965,
-0.022077681,
0.009446827,
-0.02516961,
-0.0019357442,
0.00033489033,
-0.016078025,
0.008104798,
-0.018117381,
0.044234306,
0.017025338,
0.019130481,
-0.010275726,
0.022643438,
0.02516961,
0.021748753,
-0.017827924,
-0.018104225,
0.007558777,
0.009032377,
0.0053812703,
0.01955151,
0.017748982,
-0.019814653,
-0.008367941,
-0.015525425,
0.021827696,
-0.00888107,
-0.019788338,
-0.007006177,
-0.02419598,
-0.009144212,
0.0023715745,
-0.032734964,
0.023353923,
-0.025353808,
-0.02434071,
0.02791945,
-0.00957182,
0.018841024,
-0.010124419,
0.024735423,
-0.023669695,
0.030814022,
-0.015012297,
0.023051308,
-0.0005020271,
-0.00386491,
-0.006960127,
-0.011795376,
0.014814939,
0.005907556,
0.020025168,
0.008170584,
-0.013091355,
0.004210285,
0.0007972405,
-0.011025683,
-0.032234993,
0.015433325,
-0.0063318736,
-0.010782276,
0.010887533,
0.0051641776,
-0.040181905,
-0.027445795,
-0.010630969,
0.010525712,
0.027814195,
-0.028550994,
-0.004660917,
0.015235968,
0.0008383565,
0.020393567,
-0.009841541,
0.03197185,
0.0026643209,
-0.01582804,
-0.018893654,
0.0026922799,
0.003345203,
-0.005216806,
0.032498136,
0.012920312,
0.0015311622,
-0.0061443844,
0.028445737,
0.007887705,
-0.0060950452,
-0.037918877,
0.003578742,
0.008861334,
-0.0071706413,
-0.003716892,
-0.0083284695,
-0.004558949,
0.0055358666,
-0.023524966,
0.0017729247,
-0.019669924,
0.004361592,
0.011433555,
0.0054700808,
-0.0068153986,
0.015749097,
0.0025311047,
0.0068351342,
-0.019446254,
-0.018288424,
-0.009124476,
-0.0063055595,
-0.009986269,
0.022301352,
0.005203649,
0.01490704,
-0.0016158613,
0.009545505,
0.005835192,
-0.0074469415,
-0.013643954,
0.036313705,
-0.0047365706,
-0.020854067,
-0.014104454,
0.022064524,
-0.0014661988,
0.011012526,
0.000555478,
-0.008657398,
0.0025557745,
-0.008920541,
0.02741948,
0.022932895,
0.007328527,
0.006693695,
-0.01136119,
-0.022025052,
-0.028498365,
-0.013775526,
0.01499914,
-0.026485322,
-0.0017795032,
0.012486126,
0.0033287564,
0.029971965,
0.0011923658,
-0.014486011,
-0.044892162,
0.021235624,
-0.014012354,
0.027182652,
0.007492991,
-0.014025511,
-0.01785424,
-0.0018617354,
-0.002332103,
-0.016170125,
0.02102511,
-0.016999025,
-0.02690635,
0.00823637,
-0.00027815017,
0.0021265228,
0.011005947,
-0.009400777,
0.008025856,
-0.00694697,
0.004743149,
-0.0066772485,
-0.023669695,
0.010019162,
-0.00026047026,
-0.01361764,
0.0038616206,
-0.009756019,
0.020446196,
-0.007354841,
-0.012196668,
-0.0056509916,
-0.013880783,
-0.01361764,
-0.011690119,
0.024603851,
-0.013380812,
0.0042398884,
-0.004499742,
-0.011519076,
-0.038945135,
0.008867912,
0.0085521415,
-0.0050951024,
-0.0029373316,
0.013814997,
0.013749211,
-0.009045534,
0.018801553,
0.0051674666,
0.0042069955,
-0.015446482,
-0.024695951,
-0.007420627,
-0.005269435,
0.038392536,
-0.0070785414,
-0.014788626,
-0.016446425,
0.013163718,
-0.044102732,
-0.02277501,
0.024485437,
0.010400719,
0.007861391,
0.022090837,
0.0012729533,
-0.018419996,
-0.02139351,
0.011755904,
-0.01205194,
-0.005032606,
0.03147188,
0.02686688,
0.02852468,
0.020314625,
-0.01936731,
0.007631141,
0.02598535,
-0.005999656,
-0.012032204,
0.00842057,
-0.0020344227,
0.014051826,
-0.005736513,
0.009269205,
0.012795319,
0.018498939,
0.03612951,
-0.017551625,
-0.014683369,
0.014828097,
-0.03086665,
-0.018104225,
-0.004950374,
-0.00026375955,
0.0034701957,
0.01734111,
0.0006298981,
-0.00722327,
0.029629879,
-0.00814427,
0.035182193,
0.00823637,
0.016617468,
0.0075653554,
0.0045293453,
-0.018327896,
-0.027893137,
0.003841885,
-0.024959095,
0.01623591,
0.0037760993,
-0.01338739,
-0.009052113,
-0.011492762,
0.0047628847,
-0.02001201,
0.006400949,
-0.0014423515,
-0.01417024,
-0.011558548,
-0.0011528943,
0.021288253,
0.004249756,
-0.016762197,
0.010894112,
-0.006887763,
-0.011841426,
-0.012446654,
0.005802299,
-0.0069995984,
0.021261938,
0.009670498,
-0.0023534833,
-0.02203821,
0.016564839,
0.009407355,
-0.037734676,
0.018696295,
0.17609516,
-0.009348148,
0.0054635024,
0.014222869,
-0.0020673156,
-0.030419309,
0.0023518389,
0.014551797,
-0.011848005,
0.0027120155,
0.0061114915,
0.014091297,
-0.0095783975,
-0.0019242318,
0.010736226,
-0.022156624,
-0.036708422,
0.0010607945,
-0.0044372454,
-0.016617468,
0.0010188561,
-0.020367254,
-0.031708706,
-0.015038611,
0.024380181,
-0.00013506626,
-0.03186659,
-0.008427148,
0.030208794,
0.00020948634,
-0.0021002085,
-0.0002736274,
0.0032448797,
0.0048516956,
-0.0049207704,
-0.015946453,
0.031024536,
-0.004595131,
0.0029225298,
0.009716548,
0.00846662,
0.028261537,
0.014683369,
0.004144499,
-0.0015163604,
0.009354726,
-0.015709626,
-0.018183168,
-0.0019340996,
0.0011487828,
-0.027182652,
-0.0025195924,
-0.0007034958,
0.018104225,
0.010519134,
0.0052496986,
0.007492991,
0.022419767,
-0.0045852633,
0.03744522,
-0.01518334,
0.024906466,
-0.027708936,
0.014499168,
-0.024301238,
0.026748465,
0.0016610889,
-0.0025311047,
0.005345088,
-0.015538583,
-0.00047900213,
-0.024314394,
-0.035366394,
-0.002971869,
-0.013407126,
0.0050852345,
0.041892335,
0.01706481,
0.012170355,
0.047734104,
0.0042300206,
0.014209711,
-0.04747096,
-0.011611176,
-0.0072166915,
-0.05023396,
0.03226131,
0.0149201965,
-0.017170068,
-0.0072298483,
0.0128150545,
0.00934157,
-0.00026293722,
-0.0133281825,
0.007874548,
-0.010742805,
0.005045763,
-0.00029500775,
0.0014908684,
0.009328412,
-0.022998681,
0.059470274,
-0.011341454,
-0.0041510775,
-0.013472911,
0.010130998,
-0.025380123,
0.016354324,
0.0038188598,
-0.0066048843,
-0.00007138777,
0.0058088773,
0.0024554513,
-0.01417024,
0.01306504,
0.030892964,
0.025103822,
-0.013762369,
0.028972022,
-0.013736054,
0.011492762,
0.011992733,
0.0019604138,
0.012492704,
-0.012795319,
-0.005851638,
-0.0048878775,
0.008492934,
-0.006868027,
-0.024432808,
0.0026939244,
-0.012525598,
-0.02281448,
-0.004308963,
-0.017946338,
-0.007999541,
0.008295577,
-0.0050687883,
-0.020906696,
0.016577996,
-0.017696353,
0.0068746055,
-0.004604999,
-0.00957182,
0.016959554,
-0.010920426,
0.045471076,
0.016222754,
-0.0107691195,
-0.01770951,
-0.012979519,
0.009256048,
-0.004480006,
-0.018591039,
0.0051510204,
-0.022051366,
-0.035997935,
-0.043997478,
0.00017176235,
0.010775697,
-0.02134088,
0.008486356,
0.024985408,
-0.0129860975,
-0.007604827,
0.0076377196,
-0.16609573,
-0.0013173587,
0.00796007,
-0.015959611,
0.033287566,
0.004430667,
-0.0025755102,
0.026551109,
0.006795663,
0.0113348765,
0.05489159,
-0.0014653765,
-0.046076305,
-0.031629764,
0.013196612,
0.015538583,
-0.009196841,
0.019196268,
0.036076877,
-0.003795835,
0.02668268,
-0.023867052,
0.008979748,
-0.021130366,
0.011525654,
0.022603966,
-0.002746553,
0.027261594,
-0.008348205,
-0.02511698,
-0.025590638,
-0.013907097,
0.03412962,
-0.008815284,
0.008025856,
0.0073022125,
0.00961787,
-0.011624333,
-0.008387676,
-0.0013716319,
0.017367424,
0.023485495,
-0.0021955979,
0.004131342,
-0.005736513,
-0.007953491,
-0.00033489033,
-0.0035162456,
0.023814423,
-0.023603909,
-0.0045984206,
-0.012203247,
-0.0073219487,
0.0058549275,
0.02470911,
0.004914192,
-0.013117668,
0.036971565,
-0.0098020695,
-0.004039242,
0.012453233,
-0.025630109,
0.03247182,
-0.010644127,
0.0050720773,
-0.019762024,
0.0006508673,
0.010058634,
-0.021459294,
-0.0049701096,
-0.01186774,
-0.0076771914,
-0.006285824,
-0.017104283,
0.017077968,
0.0011150676,
-0.009795491,
0.0075982483,
0.010124419,
0.007098277,
-0.0024916334,
0.0037432064,
-0.034050677,
-0.0038254384,
-0.011723012,
-0.0044010635,
0.005203649,
-0.0067331665,
0.0066048843,
-0.010571762,
0.014183397,
-0.03468222,
0.009828384,
-0.0057299347,
0.030761393,
-0.004545792,
-0.0043319883,
0.0011742747,
-0.0062496415,
-0.011880898,
0.011473026,
0.0005468436,
-0.03265602,
0.041287106,
0.022735538,
-0.0011035551,
-0.017130597,
-0.014354439,
0.05799667,
0.0045425026,
-0.019538352,
0.0071377484,
0.008308734,
0.04686573,
-0.031708706,
0.042760704,
-0.014104454,
-0.017775295,
-0.0038221492,
-0.023024995,
0.040971335,
0.0010575051,
-0.020906696,
0.008223212,
0.0008363007,
-0.031392936,
-0.13115036,
-0.014972826,
-0.00227783,
0.006016102,
-0.0032317226,
0.021669809,
-0.0013354497,
0.0058549275,
0.00842057,
0.019709395,
-0.008216634,
-0.03676105,
-0.013736054,
-0.033313878,
-0.0051345737,
-0.009144212,
-0.002060737,
-0.014880725,
-0.02028831,
0.016499054,
0.021196153,
-0.023406552,
0.00372676,
-0.012821633,
0.013268976,
-0.0039175386,
-0.013591326,
0.0027399743,
0.007190377,
-0.0120782545,
0.031103479,
-0.016591154,
0.010966476,
-0.030050907,
0.000614274,
0.0033517815,
-0.018643668,
-0.01601224,
0.029103594,
-0.015433325,
-0.004269492,
0.007835077,
0.026274808,
0.007979806,
0.024314394,
-0.009637605,
-0.031103479,
-0.0004522767,
-0.0013518961,
-0.028603623,
-0.0065950165,
-0.026116922,
-0.041918647,
-0.010492819,
0.0076377196,
0.0011627623,
0.0064338413,
0.018051596,
-0.010124419,
-0.014275497,
-0.010591498,
-0.0071706413,
-0.024143351,
0.024485437,
0.0016438202,
-0.018617352,
-0.022130309,
-0.0053483774,
0.0033879636,
-0.041944962,
-0.002216978,
0.002823851,
-0.010124419,
-0.0008321891,
-0.022709224,
0.011762483,
-0.021511924,
-0.021011952,
-0.0023567728,
-0.029235166,
0.011348033,
-0.039813507,
0.017775295,
-0.013565011,
0.014196554,
0.019775182,
0.009808647,
0.022459239,
-0.012913733,
-0.009367884,
0.011808533,
0.025748523,
0.005111549,
-0.00625622,
-0.0005012048,
0.013301869,
-0.01338739,
-0.018117381,
0.008940277,
-0.016643783,
-0.010328355,
-0.013565011,
-0.034576964,
0.00934157,
-0.015788568,
-0.036261078,
0.012940047,
-0.0066081737,
0.017591096,
-0.015512268,
0.0045753955,
0.05010239,
-0.02336708,
0.019788338,
0.000040807692,
0.0056608594,
-0.038839877,
-0.018617352,
0.028945709,
0.020867225,
0.029682508,
0.018248953,
-0.003924117,
0.00676277,
-0.008348205,
0.021446139,
-0.021669809,
0.0017696354,
-0.019630453,
0.017117439,
-0.007992962,
-0.023577595,
0.021209309,
-0.024090724,
0.0021281673,
0.0029521333,
-0.01899891,
-0.0041708136,
0.012275612,
0.017485838,
0.023906523,
0.06457524,
-0.020867225,
-0.020261995,
-0.025156451,
-0.013367654,
0.004131342,
0.009249469,
-0.00888107,
0.009144212,
-0.00892712,
0.004512899,
0.029419364,
0.02240661,
-0.0046905205,
-0.02594588,
0.0060950452,
-0.003993192,
0.0028041154,
-0.0032646153,
-0.0033287564,
-0.009644183,
0.031024536,
0.00726932,
0.0020327782,
0.011479605,
-0.006887763,
-0.008486356,
-0.017643725,
0.009163948,
0.01706481,
-0.035024308,
-0.019196268,
-0.017354269,
-0.004305674,
-0.0005534222,
0.027551051,
-0.021130366,
-0.012953204,
0.0068746055,
-0.004999713,
0.018235795,
0.012466391,
0.0043319883,
-0.0021413246,
0.0043352777,
0.025103822,
-0.0034932208,
0.025630109,
0.025353808,
-0.011157255,
0.023801267,
-0.02015674,
0.017420053,
0.021011952,
0.0057430915,
0.0015073149,
0.015656997,
0.0050852345,
-0.012821633,
0.008992905,
0.0056509916,
0.00322021,
-0.008940277,
0.0023814423,
-0.020604081,
-0.008710027,
0.0033419135,
-0.030550878,
-0.018577881,
-0.015038611,
0.02231451,
-0.014762311,
0.01868314,
-0.0033155994,
-0.00077750476,
-0.032550763,
0.017893711,
-0.017367424,
-0.014143925,
-0.01623591,
0.02194611,
0.030761393,
0.01678851,
0.0026906352,
-0.023538124,
0.020117268,
0.012104569,
0.01163749,
-0.006914077,
0.034576964,
0.010249412,
0.01868314,
-0.0018913388,
-0.031682394,
-0.020261995,
-0.0025327494,
-0.004766174,
0.010578341,
0.010012584,
-0.0028501654,
0.065733075,
-0.00018430276,
-0.009479719,
0.03565585,
-0.030787708,
0.019630453,
0.031313993,
-0.0065621235,
0.009723127,
0.0042958064,
0.028629936,
-0.013413704,
0.036997877,
-0.012341398,
-0.017577939,
0.017683197,
-0.017538467,
0.026708994,
-0.015275439,
0.010466505,
0.022169782,
-0.01186774,
0.04126079,
0.010361248,
-0.036787365,
0.0042563346,
0.04686573,
-0.010262569,
-0.0026988583,
-0.034471706,
0.009867855,
0.023617066,
-0.04031348,
0.008367941,
-0.011782219,
-0.0000449193,
-0.020775124,
-0.0033715172,
0.032050792,
0.012341398,
0.004072135,
-0.010880955,
-0.031998165,
-0.011301983,
-0.023064466,
-0.009453405,
-0.020538295,
-0.018709453,
-0.012367711
] |
Phosphoenolpyruvate (PEP) is an important precursor for anaerobic production of succinate and malate. Although inactivating PEP/carbohydrate phosphotransferase systems (PTS) could increase PEP supply, the resulting strain had a low glucose utilization rate. In order to improve anaerobic glucose utilization rate for efficient production of succinate and malate, combinatorial modulation of galactose permease (galP) and glucokinase (glk) gene expression was carried out in chromosome of an Escherichia coli strain with inactivated PTS. Libraries of artificial regulatory
|
[
-0.007839201,
-0.021920359,
0.012102978,
-0.044669412,
-0.018298153,
0.016894715,
0.0024894308,
-0.015638305,
-0.024981188,
-0.017228866,
0.02082434,
0.02507475,
0.0148096075,
0.03055484,
0.001976508,
-0.013820519,
0.03616859,
0.001400096,
-0.021532742,
0.013940813,
-0.014649215,
-0.009997821,
-0.0100780185,
-0.0039897724,
0.021252055,
0.018284786,
0.007291192,
-0.025809884,
-0.026865805,
-0.0021252055,
0.027667768,
-0.014555653,
0.0063254936,
0.01831152,
-0.008019643,
-0.04263777,
0.011287647,
-0.015076929,
0.0027199956,
0.006322152,
0.007832518,
0.025088117,
-0.009690402,
0.00816667,
0.006412373,
-0.010639393,
0.0066529624,
-0.0013299241,
-0.0006904412,
0.040098216,
-0.005844315,
-0.00030491353,
-0.0023190135,
-0.0012046172,
-0.008053059,
-0.010893349,
-0.0068300627,
0.019514466,
-0.0025462366,
-0.03092909,
-0.008554286,
-0.0052094264,
-0.02419259,
0.012671036,
0.017629849,
0.008647849,
0.0043439735,
0.02225451,
-0.0041067256,
0.001913019,
0.018859528,
0.005954585,
0.0016799482,
-0.0011544945,
0.019140216,
-0.022882715,
-0.019608028,
-0.03392309,
-0.020877805,
0.013486367,
0.013586612,
-0.024540108,
-0.029031107,
0.03154393,
0.004708199,
-0.006639596,
0.010064652,
0.015411081,
-0.0029639264,
-0.007839201,
0.022842618,
0.039937824,
0.027587572,
0.009844112,
-0.012530692,
-0.0018060905,
0.00040327944,
0.026384626,
0.022401536,
-0.024419812,
-0.018177858,
0.010311925,
-0.027453912,
-0.018659037,
-0.029886536,
0.0108532505,
0.0014410296,
-0.025596028,
0.009804014,
0.0018829454,
-0.011394576,
0.047529753,
-0.0130720185,
-0.02593018,
0.013005188,
-0.0064658374,
0.018886259,
0.009215906,
-0.009342885,
-0.019180313,
0.033575572,
-0.0025111507,
0.013753688,
0.0033732625,
0.024473278,
0.013900715,
0.0029772925,
-0.0021820113,
-0.0016624052,
-0.011869072,
0.010619344,
0.0037491831,
0.003077538,
0.01032529,
-0.012096295,
0.02637126,
-0.022374805,
-0.024834162,
-0.010084701,
-0.03905566,
0.007070652,
0.0045377812,
-0.015036831,
0.0043172413,
-0.0047015157,
0.017095206,
0.044108037,
0.02194709,
-0.00016728474,
0.0136267105,
0.026692046,
-0.006876844,
-0.001646533,
-0.0016365084,
0.021105027,
-0.0029271697,
-0.01069954,
0.022962911,
-0.03092909,
-0.022455001,
-0.01956793,
-0.028710322,
-0.021158492,
-0.012637621,
0.008313697,
0.028817251,
0.001580538,
0.013860617,
0.0017100219,
-0.013566563,
-0.0023390625,
0.00090137444,
-0.024232687,
0.029378626,
-0.009389666,
0.016012555,
-0.0030391107,
0.011307697,
-0.009616889,
-0.009015416,
0.026718779,
0.019594662,
0.012463862,
0.024058929,
0.0023106597,
-0.0010826518,
0.00015183022,
0.00014493834,
0.010392121,
-0.02306984,
-0.00069461804,
0.013767054,
0.0052862815,
-0.02718659,
-0.6360112,
-0.029031107,
0.009489911,
-0.021011464,
-0.0024342958,
0.021238688,
0.022829251,
-0.017402625,
-0.017923903,
0.025596028,
0.01054583,
0.0013499733,
-0.019487733,
0.002918816,
0.0010534135,
-0.030127127,
0.002689922,
-0.02687917,
0.028015286,
-0.016520465,
-0.01895309,
-0.004033212,
-0.0029422066,
0.01983525,
0.019434268,
0.011341112,
0.025141582,
-0.008741411,
-0.011955951,
0.039349716,
0.004477634,
0.02531534,
-0.018725866,
-0.017188769,
0.05934536,
0.010806469,
-0.019781787,
0.0009406373,
-0.0026514945,
0.041060574,
0.012363616,
-0.018659037,
0.0041501652,
0.014194768,
-0.01243713,
0.017055107,
0.012918308,
0.006786623,
0.010646076,
-0.026518287,
0.00090638676,
-0.010712907,
0.008995366,
0.02232134,
0.016480366,
0.010291875,
-0.00029363588,
-0.031463735,
0.012076246,
-0.00015652923,
0.017135303,
0.004942105,
0.0035019107,
-0.021826796,
-0.029164769,
0.007992911,
-0.012924992,
-0.010879982,
-0.0037191096,
0.0067131096,
0.026411358,
0.002425942,
-0.011735411,
0.007618661,
-0.0023958683,
0.012510643,
-0.0020533628,
0.017656581,
-0.009476545,
-0.002704959,
-0.02106493,
0.00644913,
-0.019781787,
0.00028883247,
0.025021287,
0.0066162054,
-0.043573394,
0.011334429,
0.0014368527,
-0.00151872,
0.03127661,
0.00015726019,
-0.014061107,
-0.022428269,
-0.028977644,
0.009249322,
-0.037825983,
-0.014796241,
0.032746878,
-0.036275517,
-0.029833073,
-0.015504643,
0.0068233795,
0.0020349845,
0.044562485,
0.007144165,
-0.034003288,
0.0016323315,
0.03964377,
-0.007284509,
-0.0026648606,
0.002758423,
0.006936991,
-0.0067765983,
0.012310152,
-0.027641037,
0.017549653,
-0.009222589,
-0.00018545425,
-0.04675452,
-0.0019598003,
0.004180239,
-0.0016431914,
0.0020483504,
-0.01019163,
0.027266787,
0.0059579266,
-0.011862389,
-0.014569018,
0.00068668195,
-0.018899625,
-0.02381834,
0.035393357,
-0.0069704065,
0.018872894,
0.0111473035,
0.033441912,
0.003922942,
0.0040398953,
-0.027266787,
-0.013232411,
-0.017629849,
0.0050089355,
0.031169679,
-0.011247549,
-0.0073780715,
0.008768143,
-0.0050690826,
0.010098067,
0.006452471,
0.017121937,
0.009469862,
-0.021358984,
0.0010651088,
-0.010806469,
-0.017362528,
-0.022655493,
-0.02780143,
-0.014970001,
-0.0025763104,
0.0019481049,
0.0037725738,
-0.009670353,
-0.0033181272,
-0.014929902,
-0.01214976,
0.0091891745,
0.0041000424,
-0.0095233265,
-0.012871527,
-0.012096295,
-0.009810696,
0.0044475603,
0.0030173906,
-0.009857478,
0.017135303,
-0.015531375,
-0.009757233,
0.008380527,
0.011434674,
0.005135913,
-0.010178263,
-0.009169125,
0.01296509,
0.008661214,
0.028122215,
0.0063655917,
0.024981188,
-0.0045645135,
0.028389536,
0.002392527,
0.02238817,
-0.011047059,
-0.004527757,
0.0049822032,
0.00029676856,
-0.009850795,
-0.010017871,
-0.019140216,
0.022120848,
0.012156443,
-0.030447911,
0.020543652,
-0.027373714,
0.024713866,
-0.035099305,
-0.0058743884,
-0.027146492,
0.019367438,
0.011067107,
-0.002938865,
-0.0052862815,
-0.015370983,
0.0027617647,
-0.008139938,
0.0075384644,
-0.0030140493,
-0.0013616686,
-0.014929902,
-0.029218232,
-0.0087079955,
-0.020436725,
0.022855982,
-0.0042604352,
-0.023256965,
0.011040376,
0.004785054,
0.009910942,
-0.015397714,
0.0033598964,
-0.01287821,
0.009543375,
0.015210589,
0.00695704,
0.018525375,
0.019728322,
0.028469734,
-0.0023691363,
0.048411913,
0.0033365057,
-0.0018044197,
0.019808518,
-0.0041969465,
0.00876146,
-0.0045110495,
0.010318607,
0.017736778,
0.0121096615,
-0.042958554,
0.018191224,
-0.017175402,
0.033522107,
-0.019420903,
0.015464545,
-0.0077322726,
0.008353795,
0.012443813,
0.01901992,
0.04787727,
0.014502188,
-0.0027233372,
0.0048084445,
-0.007023871,
-0.018819429,
-0.01666749,
-0.0087815095,
0.02106493,
-0.016467001,
-0.004033212,
-0.017095206,
-0.03480525,
0.012243322,
0.007952813,
-0.010098067,
-0.012644304,
0.0060915872,
-0.001684125,
-0.013980911,
0.024927724,
-0.029993465,
0.002696605,
-0.033014197,
0.04314568,
0.023524286,
-0.02256193,
-0.01895309,
-0.017669948,
0.0003276776,
-0.004875275,
0.0002863263,
-0.007578563,
0.011474772,
0.000425417,
0.020463455,
-0.02589008,
-0.032265697,
0.007591929,
-0.014742778,
0.04127443,
-0.016012555,
-0.017683312,
0.025328707,
-0.028042018,
-0.019594662,
0.030875625,
-0.01252401,
-0.0075451476,
-0.011768826,
0.023497554,
-0.03555375,
0.011762143,
0.020423358,
0.019220412,
-0.007952813,
-0.01582543,
0.006549375,
-0.021706501,
0.0034618126,
0.02967268,
0.0035854487,
-0.00041810743,
-0.021706501,
0.013446269,
0.0023507578,
0.013566563,
0.036435913,
0.013125483,
0.011655214,
-0.014916536,
0.024433179,
-0.009837429,
-0.05284945,
0.010966862,
-0.004110067,
-0.011822291,
-0.009690402,
0.0061884914,
0.0038460873,
0.030822162,
0.013593295,
-0.014101205,
-0.04605948,
0.003410019,
-0.0018695793,
0.026250966,
-0.012798014,
0.013138848,
0.028416269,
0.020089205,
0.01206288,
0.031757787,
0.011615116,
0.00009716508,
0.012791331,
-0.008514188,
-0.0026047132,
0.009643621,
0.006225248,
-0.021038197,
-0.03245282,
0.018151125,
0.0038527702,
0.015558108,
0.045792162,
0.023109939,
0.014983366,
0.000029055544,
0.007097384,
-0.005470065,
-0.013299242,
-0.0149566345,
0.020022376,
0.011528237,
-0.033735964,
0.030100394,
0.007738956,
-0.020396626,
0.007932764,
0.020971367,
-0.00988421,
-0.0037759154,
0.00025750572,
-0.0053263796,
-0.013900715,
-0.012169808,
-0.022535197,
0.024272786,
0.0080062775,
0.003942991,
0.04188927,
-0.017135303,
-0.020810975,
-0.038333893,
-0.0074983663,
-0.012918308,
-0.032746878,
-0.014208134,
0.0013457964,
0.00045444645,
0.022281243,
-0.003458471,
-0.008313697,
-0.0010943471,
0.019808518,
-0.02892418,
0.010779737,
-0.013198996,
-0.04279816,
0.012510643,
0.005904462,
0.010305242,
-0.008514188,
-0.016092751,
-0.016614027,
0.018899625,
-0.0064223977,
-0.009035464,
0.004965496,
0.0022705614,
0.0067331586,
0.02269559,
0.003999797,
-0.00189297,
0.013466317,
-0.01565167,
-0.02718659,
0.007899349,
-0.03170432,
0.0017108571,
-0.0021669744,
-0.0006353061,
-0.0108532505,
0.0037024019,
0.000712161,
0.008768143,
0.012102978,
0.010305242,
0.029886536,
0.009108978,
0.021733234,
0.0064290804,
0.008661214,
-0.018832795,
-0.010017871,
-0.017295698,
-0.013767054,
0.012624254,
-0.004096701,
-0.006101612,
0.018084295,
0.018177858,
-0.030474644,
-0.024606938,
0.020369893,
-0.019581296,
0.04814459,
0.0013040274,
-0.008627799,
-0.036729965,
0.008687947,
-0.02276242,
0.008286964,
0.004330607,
-0.019861983,
-0.015678402,
0.0041468237,
-0.005343087,
-0.03157066,
0.010793103,
-0.029351894,
-0.018244687,
-0.016908081,
-0.024807429,
0.021679768,
-0.014341795,
0.0044275112,
-0.024419812,
-0.0026230917,
-0.022976277,
-0.035847805,
-0.018151125,
-0.013673492,
0.03616859,
0.035126038,
0.03616859,
-0.018565474,
0.0037191096,
0.02450001,
0.004043237,
-0.007932764,
-0.009403031,
0.0061517344,
-0.03191818,
0.030768698,
0.00636225,
-0.0040766518,
0.0035553752,
0.005045692,
0.0052294754,
0.005984659,
-0.0081533035,
-0.023537653,
-0.013940813,
-0.025849983,
-0.04293182,
0.022428269,
-0.013640076,
0.0027550815,
-0.034217145,
-0.028897448,
0.026250966,
0.026999464,
0.01190917,
-0.0027884967,
0.03977743,
-0.029378626,
0.021158492,
0.020022376,
0.022134215,
0.008340429,
-0.04063286,
-0.003652279,
0.0048151272,
0.010225045,
0.020476822,
0.018605571,
-0.0005246183,
-0.012497277,
-0.0027918383,
0.02351092,
-0.019928813,
-0.0011611775,
-0.013299242,
-0.026892537,
-0.019140216,
-0.0014652556,
-0.012891577,
-0.05063068,
-0.0065827905,
-0.00091557595,
-0.021385714,
0.017402625,
-0.010405487,
0.009556741,
0.01994218,
0.013025237,
0.020837706,
-0.01919368,
0.038333893,
-0.0041167503,
0.0073112412,
-0.024393082,
-0.0012889906,
0.019313974,
-0.009623571,
0.02599701,
0.0055268705,
-0.0016147885,
-0.014368528,
-0.0117420945,
0.021412447,
-0.02742718,
-0.010646076,
0.03590127,
-0.0096302545,
0.00975055,
-0.009503277,
-0.0058710473,
-0.007063969,
0.014127938,
-0.008340429,
0.02014267,
0.008768143,
-0.0020466798,
-0.012864844,
0.011708679,
-0.0061082947,
0.0037024019,
0.0110002775,
-0.0040098215,
0.011153987,
-0.010398804,
-0.012263371,
0.040338803,
-0.007678808,
-0.0027316909,
0.0033047614,
0.020837706,
-0.010285192,
-0.0025261876,
0.015999189,
-0.00048201397,
-0.0025178338,
0.030340983,
0.0059512435,
-0.007224362,
0.012691085,
0.008099839,
0.016413536,
-0.0035052523,
0.008393893,
-0.03913586,
-0.022789152,
0.0064424467,
0.0035553752,
0.017442724,
-0.042824894,
-0.0021034856,
-0.010204996,
0.011053741,
-0.0195011,
-0.011327746,
0.031116216,
-0.033014197,
-0.017095206,
-0.019354071,
0.015638305,
0.009536692,
-0.008614433,
-0.0043372903,
-0.017228866,
0.018351616,
0.010265144,
0.010793103,
0.010271826,
-0.0038828438,
-0.00059562555,
-0.0057206787,
-0.024473278,
0.00002913386,
0.020958,
-0.014689313,
-0.010044603,
0.011047059,
-0.019300608,
0.006936991,
0.012189858,
0.0039964556,
0.0057841674,
0.0049487883,
0.024219323,
-0.003652279,
0.014876438,
-0.0034050068,
-0.014301697,
0.017563019,
0.02555593,
-0.032934003,
-0.008681264,
0.008581018,
-0.021185223,
-0.0044442187,
-0.011107205,
-0.02494109,
-0.016948178,
0.007257777,
0.012604206,
-0.009810696,
0.014408626,
-0.011528237,
-0.0070105046,
-0.0030391107,
0.018739233,
-0.0016874665,
-0.023898536,
-0.038333893,
-0.009483228,
0.01428833,
-0.021786697,
-0.0016799482,
-0.0047783707,
-0.019968912,
0.009242639,
0.0044041206,
-0.011267599,
0.037825983,
-0.002370807,
-0.054159325,
-0.020958,
0.0019948862,
-0.033308253,
-0.009195858,
-0.014889804,
0.0021803405,
0.012490594,
0.013807152,
-0.019166946,
-0.006452471,
-0.013726956,
0.012971773,
-0.036462642,
-0.017041741,
0.031998377,
0.0022137556,
0.0064290804,
-0.0041835806,
-0.024433179,
-0.008621116,
0.032559752,
0.011280965,
0.0118490225,
0.03245282,
0.009449813,
0.020423358,
-0.010358706,
0.021653036,
0.01864567,
0.010178263,
0.019728322,
-0.017496187,
-0.015103661,
0.020770876,
-0.0023206843,
0.011615116,
-0.006024757,
0.01287821,
-0.01378042,
0.009015416,
-0.002364124,
-0.0109267635,
0.0089686345,
0.0072176787,
-0.009583473,
0.013065335,
-0.004470951,
-0.0062085404,
0.027774697,
-0.02150601,
-0.01408784,
0.007972862,
-0.025716322,
-0.006004708,
0.028336072,
0.013325973,
-0.015571474,
0.0076654423,
-0.0046480517,
-0.009015416,
-0.014261599,
0.0020917903,
-0.0030541474,
0.000026940988,
0.015798697,
0.01666749,
-0.010151532,
-0.0055536027,
-0.010859934,
-0.012276737,
0.0016206362,
0.008327063,
-0.00077648525,
0.006522643,
0.0046747834,
-0.007124116,
-0.031490464,
0.001796066,
0.009235956,
-0.01032529,
-0.024807429,
-0.00189297,
0.17953308,
-0.006716451,
0.01708184,
0.0404992,
0.0039396496,
-0.0036856944,
-0.016453635,
-0.0075384644,
-0.001268106,
0.011828974,
0.017883804,
0.010405487,
-0.030234054,
-0.010071335,
0.0035821074,
0.019915447,
-0.046781253,
-0.0041568484,
-0.017696679,
-0.0061884914,
0.0069904556,
-0.0064457883,
0.010472317,
0.00704392,
0.031383537,
-0.00288373,
0.013025237,
0.0022237801,
0.019447634,
0.011301014,
0.00075560075,
0.01776351,
-0.008594384,
0.015424447,
0.017108573,
0.008133255,
0.007464951,
-0.024032198,
0.014569018,
0.018672403,
-0.008474089,
0.021519376,
-0.00016968646,
-0.010886665,
-0.05009604,
-0.007852567,
-0.0036155225,
-0.0013457964,
-0.019634759,
-0.0061684423,
-0.033896357,
0.0024393082,
0.011528237,
0.01303192,
0.0059378776,
-0.01626651,
0.0071107503,
0.0187125,
0.014729411,
0.023083206,
0.00088049,
0.016614027,
-0.01833825,
0.030073661,
-0.0050423504,
0.014315063,
-0.026839072,
-0.011802241,
0.014822974,
-0.0137002235,
-0.014863072,
-0.024767332,
0.013486367,
0.019287242,
-0.021519376,
-0.009603523,
0.02375151,
0.014876438,
0.021933723,
0.020075839,
-0.0022438294,
-0.002745057,
-0.04065959,
0.005620433,
-0.00975055,
-0.037264608,
0.027881626,
0.0034283975,
-0.02606384,
-0.018030832,
0.014702679,
-0.005182694,
-0.025449,
-0.0037324755,
-0.0247406,
-0.021252055,
0.014194768,
-0.01019163,
0.008246866,
-0.018979821,
-0.029164769,
0.070252076,
-0.027173225,
0.020744143,
-0.035954732,
-0.0083003305,
-0.023083206,
0.017162036,
-0.0033715917,
0.0011653544,
0.0005513505,
-0.029031107,
-0.0036923774,
-0.0067565492,
0.0023323796,
0.009650304,
0.008507505,
-0.0003310191,
0.030340983,
-0.026451455,
-0.020463455,
-0.004013163,
-0.0059378776,
-0.008721362,
-0.0028386195,
0.012798014,
-0.030795429,
0.0034818617,
-0.030822162,
-0.025983643,
0.0071174335,
-0.0021402421,
0.0013240764,
0.013125483,
-0.009763915,
0.030635037,
0.003755866,
0.0032479553,
-0.0026665314,
0.03515277,
-0.019594662,
0.020998098,
0.0082268175,
0.01783034,
0.01378042,
-0.019006554,
0.007872616,
0.01514376,
-0.006539351,
-0.026464822,
0.0007284509,
-0.027908359,
-0.004400779,
-0.018552108,
0.016039286,
-0.017375894,
-0.027173225,
-0.030688502,
0.006399007,
0.008594384,
-0.016988277,
-0.0064925696,
0.017629849,
-0.008427308,
0.0148096075,
-0.011387893,
-0.16798478,
0.007912715,
-0.0024493327,
-0.024005465,
0.026037108,
0.008380527,
0.019968912,
0.021746598,
-0.006786623,
0.005025643,
0.031116216,
-0.010225045,
-0.029645948,
-0.00891517,
-0.007070652,
0.018217957,
-0.00988421,
0.02780143,
0.0008997037,
0.0084139425,
0.026277697,
-0.014822974,
0.0045244154,
-0.0011737082,
-0.0050557167,
0.014368528,
-0.0068400875,
-0.006459154,
-0.041916,
-0.017268965,
-0.0426645,
0.02606384,
0.027066296,
-0.0014318405,
0.004320583,
-0.016761053,
0.00618515,
-0.0049688374,
0.011321063,
0.01912685,
0.016453635,
0.006205199,
0.0032479553,
-0.0065193013,
-0.0026030424,
0.019461,
0.008119889,
0.0030474644,
0.02225451,
0.02711976,
0.012303469,
0.011541603,
-0.005373161,
0.026598483,
0.0018946407,
0.003612181,
-0.00763871,
0.00029676856,
-0.0076854913,
-0.014421991,
-0.0019013237,
-0.00576746,
0.01151487,
-0.0032529677,
-0.01192922,
-0.024927724,
-0.008233501,
0.0017100219,
-0.023256965,
0.013426219,
-0.00070673105,
-0.00069503573,
0.013686857,
-0.01452892,
0.016761053,
-0.00027713715,
-0.020049108,
0.026250966,
-0.027667768,
-0.00031326732,
-0.009436447,
0.021452546,
-0.030127127,
-0.013272509,
0.009242639,
0.0004045325,
0.033201322,
0.034698322,
-0.0072176787,
-0.012250005,
0.031223144,
-0.027333617,
0.0070907013,
-0.016694224,
0.038494285,
0.012584156,
-0.011080474,
0.0066429377,
-0.0071976297,
0.017750144,
0.025435634,
-0.008834974,
-0.028229143,
0.004788395,
0.033254787,
0.008834974,
0.0036589622,
-0.010759688,
0.059933465,
0.009991139,
-0.012463862,
-0.005894438,
0.025876716,
0.054907825,
-0.0079661785,
0.02487426,
0.0075852457,
-0.010946813,
0.018124394,
-0.005496797,
0.034564663,
-0.00033164566,
-0.0030591597,
0.0025963595,
-0.0073379735,
-0.038868535,
-0.13954179,
-0.02817568,
0.0070105046,
0.006639596,
-0.0030040247,
0.003264663,
-0.0024593573,
0.0060113906,
-0.0018545425,
0.02225451,
-0.001877933,
-0.026344528,
-0.00200324,
0.005135913,
0.02857666,
-0.012530692,
0.027908359,
-0.0148096075,
-0.036008198,
0.025355438,
-0.012624254,
0.016761053,
0.012798014,
0.019714955,
0.004855226,
0.005994683,
-0.020035742,
0.034751788,
0.0031310024,
0.011902487,
0.024620304,
-0.014141304,
0.031891447,
0.005864364,
0.008059741,
-0.0013015212,
-0.008955268,
-0.015304152,
0.02313667,
0.0050690826,
-0.015611572,
-0.00869463,
0.03127661,
0.004250411,
0.011387893,
-0.018364983,
-0.022775786,
0.010131482,
0.0032228942,
-0.027908359,
-0.024058929,
-0.0027701184,
-0.033067662,
0.0069503575,
0.012263371,
-0.022294607,
0.0016231424,
0.024687136,
0.007464951,
-0.019795153,
-0.004487659,
0.003542009,
-0.0009498265,
-0.0031393562,
0.0041568484,
-0.010418853,
-0.028443001,
-0.044188235,
0.014863072,
-0.03787945,
-0.00094732037,
0.031249875,
0.0014326759,
-0.0016106117,
-0.020169402,
-0.0013683516,
-0.006549375,
-0.008748094,
0.008527554,
-0.005780826,
-0.026932634,
-0.03480525,
0.023738144,
-0.030982554,
0.0010024554,
-0.0016983266,
0.040445734,
0.015451179,
0.019207045,
-0.019541197,
-0.025449,
0.024620304,
0.008995366,
-0.008614433,
-0.008433991,
0.036115125,
-0.024780698,
-0.008581018,
0.014716045,
0.025636125,
-0.010405487,
-0.026531653,
-0.058383003,
0.010011188,
0.031517196,
0.0028603394,
0.014876438,
-0.0006549375,
0.0020199476,
0.0149566345,
-0.000009613391,
-0.013232411,
-0.03245282,
-0.0028219118,
-0.00814662,
-0.029645948,
-0.0019781787,
-0.008788193,
0.030474644,
-0.0030107077,
0.009543375,
0.0012154771,
-0.029111305,
0.010585929,
-0.009690402,
0.020035742,
-0.022374805,
-0.017415991,
-0.013125483,
0.027534109,
0.0007338809,
-0.02109166,
0.008701312,
-0.038922,
-0.013426219,
0.00020393702,
-0.011267599,
-0.011969318,
-0.02494109,
0.014141304,
0.00763871,
0.027961822,
-0.018659037,
-0.013452951,
0.00695704,
-0.008246866,
-0.008554286,
-0.011521554,
-0.033629037,
0.0029338528,
-0.0075317817,
0.0053196964,
0.022535197,
0.011661897,
-0.0009080575,
0.0003723704,
-0.004714882,
-0.00048284934,
-0.020303063,
0.004133458,
-0.010285192,
-0.040953644,
0.015918992,
-0.0042671184,
0.03477852,
0.0015312507,
0.0087815095,
-0.020115938,
-0.015918992,
-0.0111874025,
-0.006876844,
-0.03662304,
-0.016827885,
0.0026514945,
0.010886665,
0.023631215,
0.01758975,
-0.003645596,
0.0021937066,
-0.0032613215,
0.005754094,
0.021706501,
0.03528643,
-0.0017977366,
-0.025088117,
0.029966732,
0.033896357,
-0.020343162,
0.014261599,
0.038360626,
-0.0101849465,
0.005897779,
0.0030307567,
0.034564663,
-0.013239094,
-0.010285192,
0.00832038,
0.02306984,
0.013740322,
-0.0020734118,
0.0060915872,
0.016253144,
-0.010732955,
0.009048831,
0.008474089,
-0.01776351,
-0.01666749,
0.015223956,
-0.04627334,
-0.033468645,
-0.023724778,
-0.0035319845,
-0.0042169956,
0.012584156,
0.0028720347,
-0.006896893,
-0.017937269,
0.015344251,
-0.008340429,
-0.010171581,
-0.004367364,
0.008587701,
0.018284786,
0.017162036,
-0.0028586686,
0.0054633818,
0.02487426,
0.008380527,
0.01670759,
-0.009677036,
0.028817251,
-0.007658759,
0.00763871,
-0.009022099,
-0.025836617,
-0.05009604,
-0.0020834364,
-0.000098000455,
0.009516643,
0.017282331,
-0.009443129,
0.08057068,
0.015063563,
-0.013499732,
-0.007825835,
0.019367438,
0.0083003305,
0.010057969,
0.012042831,
0.0031076118,
-0.016132848,
0.026545018,
-0.012677719,
0.030474644,
-0.046219878,
-0.00047574862,
0.0069704065,
0.00085626397,
0.0103720715,
-0.015317518,
-0.008159987,
0.025101483,
0.0003652697,
-0.012530692,
0.015183858,
-0.030340983,
-0.004497683,
0.027306885,
0.001659899,
0.017816974,
-0.034618124,
0.0021135102,
-0.008581018,
-0.021358984,
-0.008500822,
0.019420903,
0.009202541,
0.0033916407,
-0.014127938,
0.033629037,
0.020356527,
0.004795078,
-0.007999594,
-0.019982278,
-0.03691709,
-0.011548286,
-0.018899625,
-0.0045444644,
0.0060481476,
-0.015611572
] |
Expression quantitative trait loci (eQTL) mapping aims to determine genomic regions that regulate gene transcription. Expression QTL is used to study the regulatory structure of normal tissues and to search for genetic factors in complex diseases such as cancer, diabetes, and cystic fibrosis. A modern eQTL dataset contains millions of SNPs and thousands of transcripts measured for hundreds of samples. This makes the analysis computationally complex as it involves independent testing for association for every transcript-SNP pair. The heavy computational burden makes eQTL analysis less popular, often forces analysts to restrict their attention to just a subset of transcripts and SNPs. As larger
|
[
-0.031347062,
-0.004331015,
0.020924034,
-0.043407623,
-0.0067970622,
0.028020011,
-0.03314055,
0.0044804728,
-0.033738382,
-0.01048801,
-0.010163102,
-0.011033854,
-0.0017285072,
0.010936382,
0.008330625,
-0.006940021,
0.02644746,
-0.021963738,
-0.0012127168,
-0.006309701,
-0.035505876,
0.01732406,
-0.0069010323,
-0.0028835528,
-0.021820778,
0.032906618,
0.01003314,
-0.034154262,
-0.011703163,
-0.024121122,
-0.0015774253,
0.011852621,
-0.03493404,
0.0004079618,
-0.022535576,
-0.021820778,
0.011475728,
-0.015842482,
0.018571705,
-0.0064559095,
0.015946453,
0.020937031,
-0.0076223267,
-0.012469945,
0.016141398,
0.002020924,
0.0024530506,
-0.010734939,
-0.00012975988,
0.013581128,
-0.016167391,
0.023419322,
-0.02153486,
-0.00680356,
-0.018129831,
-0.006940021,
0.018389758,
-0.014581842,
0.0044869706,
-0.0044317367,
-0.02213269,
-0.0028380658,
-0.031191107,
-0.002535902,
-0.0127493655,
0.0015246278,
0.004753395,
0.0025212811,
0.01129378,
-0.010981869,
0.020287216,
0.018675676,
0.010072129,
0.028279938,
0.025134834,
-0.024186105,
0.00515628,
0.0024530506,
0.0034505161,
0.009688738,
0.010780427,
-0.01339918,
-0.011020858,
0.019286502,
0.006160244,
0.0011745401,
0.01375008,
0.01304828,
-0.030827211,
-0.004503216,
-0.0049125995,
0.009623757,
0.025849631,
-0.0017739942,
-0.015842482,
-0.009396321,
0.015946453,
0.02599259,
0.0074468767,
-0.024017153,
-0.0034635125,
0.007804275,
-0.023159398,
-0.009968158,
-0.04444733,
0.00078790035,
0.017986871,
0.011196308,
-0.008532068,
-0.021586845,
-0.018935602,
0.032308787,
-0.010429527,
-0.012359477,
0.04247189,
-0.01069595,
-0.0029387872,
-0.005334979,
-0.018649682,
-0.0019900575,
0.035141982,
-0.0045681978,
0.010708947,
-0.018363765,
0.008064201,
0.008369613,
-0.00222724,
0.012580413,
-0.026824353,
-0.015777502,
-0.0041588144,
0.0067970622,
0.0033026834,
0.02820196,
-0.03462213,
-0.012736369,
0.009604262,
-0.014425887,
-0.02283449,
-0.022899471,
-0.0017544997,
0.01550458,
-0.028565856,
-0.0042010522,
-0.0001858064,
0.02599259,
0.020261224,
0.023510298,
0.054064587,
-0.00021200205,
0.014334913,
0.0050133206,
0.011508219,
0.016531287,
-0.0058158417,
0.015348624,
-0.0072844233,
0.022041716,
-0.009474299,
-0.028539862,
-0.0000020386033,
-0.007674312,
-0.007862758,
0.029475596,
0.010754433,
0.035064004,
0.004854116,
-0.019767364,
0.00392813,
-0.010643966,
-0.02861784,
0.015062706,
-0.02529079,
0.016089413,
0.014165961,
0.008727012,
-0.0023880692,
0.0066800956,
-0.012216517,
-0.010884397,
-0.0068230545,
0.021274934,
0.03254272,
0.0069075306,
-0.007901747,
-0.0076093306,
0.0030768728,
0.01725908,
-0.019871335,
-0.019039571,
-0.012794852,
-0.010319058,
-0.011267788,
-0.018948598,
-0.64544797,
-0.0036064717,
0.013685098,
-0.0132432245,
0.00722594,
0.009701734,
0.004142569,
-0.0018341021,
-0.01490675,
0.039014876,
-0.008876469,
0.038650982,
0.01280135,
-0.024848916,
-0.025914611,
-0.031269085,
-0.0058775744,
-0.02609656,
0.035817787,
0.007791279,
-0.025368767,
0.011007861,
0.0038501523,
0.04897004,
0.018428747,
0.029891478,
0.00038298455,
-0.0004772077,
0.020170249,
0.0075963344,
-0.025589705,
-0.00065956195,
-0.009844693,
0.020053282,
0.04338163,
-0.006914029,
-0.008317629,
0.020716093,
0.027110271,
0.028487878,
-0.0003043976,
-0.017544998,
0.04086035,
0.004090584,
-0.017934887,
0.015426602,
0.0049093505,
0.019728376,
-0.0066670994,
-0.025901616,
-0.019325491,
-0.002108649,
-0.018506724,
0.0036779514,
0.019637402,
0.0021037753,
0.021872764,
-0.012482941,
0.039352782,
0.00031231722,
-0.0010080251,
-0.003980115,
-0.006888036,
-0.010728441,
0.00011473292,
0.0057021244,
0.01872766,
0.0037656764,
0.002266229,
-0.0024595489,
0.018844627,
0.03623367,
-0.000638443,
-0.004266034,
0.03100916,
0.021833776,
0.023549287,
-0.011566702,
-0.0057118717,
0.011729156,
-0.023549287,
-0.0029192928,
-0.02188576,
-0.0062447195,
0.023328349,
-0.012658391,
-0.015634542,
0.01585548,
0.007641821,
0.023458311,
-0.026525438,
-0.001957567,
-0.00880499,
-0.04296575,
-0.027656116,
0.018701669,
-0.010156604,
0.00028977677,
0.0134901535,
-0.023133405,
-0.01922152,
-0.018571705,
-0.0041230745,
0.009753719,
0.014113976,
0.03763727,
0.0031629733,
0.008902462,
0.023822209,
-0.017038142,
-0.016479302,
0.0075248545,
-0.022015722,
-0.013158749,
-0.0053577223,
-0.032048862,
0.010501006,
0.007264929,
-0.0234973,
-0.020326205,
0.030541293,
0.016258365,
0.015634542,
-0.034804076,
0.0028429395,
0.016479302,
-0.027552145,
-0.008759502,
-0.0008134868,
-0.0046851644,
0.0016229124,
-0.017648969,
0.014919747,
-0.02308142,
-0.0041263234,
-0.009181882,
0.028046004,
0.0071349656,
-0.005032815,
-0.01385405,
0.0012955682,
-0.030645262,
0.020326205,
0.0044317367,
-0.008967443,
-0.022041716,
-0.027084278,
-0.023354342,
0.0077262972,
-0.009266358,
-0.013971017,
-0.0020014294,
-0.02328936,
0.01992332,
-0.011391252,
-0.010091623,
-0.01701215,
-0.01245045,
-0.016076416,
-0.014828772,
-0.006972512,
0.009162388,
0.009760218,
-0.010773928,
-0.007537851,
-0.009246863,
-0.033010587,
0.026109556,
-0.03714341,
-0.026772367,
0.01732406,
-0.017376047,
-0.005198518,
0.010462017,
-0.008863473,
-0.0018925854,
0.00012691694,
-0.007264929,
0.030567285,
-0.025667682,
-0.004116576,
-0.024108127,
-0.030385338,
-0.005685879,
0.018818635,
0.021417893,
-0.0016586521,
0.00424329,
0.0015571186,
0.018220805,
-0.011599193,
0.008525569,
-0.030463316,
0.03846903,
0.009006432,
0.00596205,
0.010949378,
0.010864902,
-0.004269283,
0.027942033,
0.015842482,
-0.0046136845,
-0.009032425,
-0.0033400478,
0.01311976,
-0.030645262,
-0.00036633306,
-0.012119045,
-0.004854116,
0.009181882,
0.0049190978,
-0.00740139,
-0.007719799,
0.0007192637,
-0.012229513,
0.022522578,
-0.0025440247,
-0.0008878094,
-0.001313438,
0.00361297,
0.009617258,
0.0010299564,
0.026720382,
0.015309636,
-0.014594839,
0.0091363955,
0.017350053,
-0.00058564555,
-0.01182013,
-0.007713301,
-0.0026285006,
-0.008194163,
-0.008090193,
0.0036292153,
-0.0011444862,
0.007005003,
0.019598413,
-0.010975371,
0.029397618,
0.01385405,
-0.009578269,
-0.0027438428,
-0.0051270383,
-0.008025212,
0.0011777892,
0.00082891993,
0.024575993,
0.013236727,
0.00022885663,
0.011586197,
0.008727012,
-0.000078180834,
0.004181558,
-0.013789069,
-0.002729222,
-0.003395282,
-0.0032393264,
0.014061991,
0.050945476,
0.018844627,
0.016076416,
-0.01410098,
-0.030593278,
0.0025618947,
0.0052764956,
-0.0046039373,
0.015049709,
-0.020560138,
-0.014178958,
0.009422313,
-0.031996876,
0.018012865,
0.010617972,
-0.010202091,
0.0012606406,
0.018675676,
0.009818701,
0.01971538,
0.03243875,
0.006439664,
0.0028770547,
-0.01560855,
0.040626418,
0.02599259,
-0.0072064456,
-0.018142827,
0.0034505161,
-0.0045681978,
-0.025550716,
0.0036064717,
0.029787507,
-0.00048573653,
0.018753653,
-0.015218661,
-0.01536162,
0.0031548506,
0.038806938,
-0.020079276,
-0.00047436476,
-0.00058239646,
0.0097342245,
0.0024303072,
-0.023770222,
-0.01666125,
0.04239391,
0.021521864,
-0.02791604,
-0.012664889,
0.004844369,
-0.02223666,
-0.003931379,
-0.0057183695,
-0.0033189289,
-0.014438883,
-0.0109623745,
0.012352978,
-0.0044869706,
0.029163685,
0.034700107,
-0.014373902,
-0.010552991,
-0.047748387,
0.0024043145,
0.01866268,
0.040418476,
0.014243939,
0.0029274153,
0.025030864,
-0.029943462,
-0.009779712,
-0.02006628,
-0.026850345,
0.020586131,
0.0050945478,
-0.014672817,
0.0023507047,
0.011384754,
-0.0043472606,
0.007973227,
0.009298849,
0.014035998,
-0.048736107,
-0.021586845,
0.017921891,
0.01048801,
-0.009409318,
0.016453309,
0.04153616,
0.025446745,
-0.014763791,
0.0053122356,
0.01781792,
0.020755082,
-0.007862758,
-0.014282928,
0.00933134,
0.005819091,
0.009708232,
-0.016336342,
0.020313209,
0.020469164,
-0.017557994,
0.006790564,
-0.0035057506,
0.018155824,
0.014776787,
0.017415036,
0.010007147,
0.011722658,
-0.028773796,
0.005286243,
0.013334199,
-0.006511144,
0.006075768,
0.005146533,
-0.021859767,
-0.003388784,
-0.020001298,
0.0038014161,
-0.014581842,
-0.0030590028,
-0.016232371,
0.008967443,
-0.043303654,
-0.008200662,
-0.016388327,
0.025615698,
-0.0053999606,
0.0055526667,
0.005065306,
0.001092501,
-0.019065564,
-0.02213269,
-0.015348624,
-0.008304632,
-0.027968027,
-0.024718953,
-0.021963738,
0.023978164,
0.0003636932,
0.012794852,
-0.008389108,
-0.0017707451,
0.023198387,
-0.013893039,
-0.0009032425,
-0.021807782,
-0.03563584,
-0.025316782,
-0.019377476,
0.020820064,
0.0047241533,
-0.008798491,
0.020001298,
-0.010760932,
-0.016440313,
0.012840339,
-0.012216517,
-0.008441093,
0.021469878,
0.020508153,
0.010026641,
0.033036582,
-0.01936448,
-0.022470593,
-0.03701345,
-0.0105205,
-0.026148545,
0.035064004,
-0.015790498,
0.013301708,
-0.0068490473,
0.01641432,
-0.028253945,
0.0034342709,
-0.028046004,
-0.00410358,
0.017480016,
0.02132692,
0.017272076,
0.006338943,
0.031061145,
0.008830982,
0.0022597308,
-0.00908441,
-0.009864188,
0.016245369,
-0.013646109,
-0.027032293,
0.021846771,
-0.014672817,
0.0029127945,
-0.01585548,
0.011501721,
-0.00803171,
0.027838062,
0.018389758,
-0.0037981672,
-0.021911753,
0.0020160503,
-0.015205665,
0.013971017,
-0.0011404249,
0.009974657,
-0.009649749,
0.016583271,
-0.010923386,
-0.018220805,
0.020612124,
-0.03171096,
-0.009038923,
0.020339202,
-0.010832411,
0.022288645,
0.010760932,
0.0038696467,
-0.004233543,
-0.02041718,
0.0024303072,
-0.04195204,
0.004542205,
-0.010845408,
0.038183115,
-0.00697901,
0.02890376,
-0.001004776,
0.013516147,
0.015907465,
0.00459419,
-0.0077782823,
0.0029062964,
0.016570276,
-0.0036259661,
-0.005637143,
0.019143542,
0.0032019622,
-0.004155565,
-0.013080771,
0.0016172264,
0.035115987,
-0.016167391,
-0.0030297611,
0.006836051,
-0.040730387,
-0.027682107,
0.026551431,
0.0046104356,
0.021041,
-0.03594775,
0.019338487,
0.015075702,
0.0018113586,
0.016284358,
0.005952303,
0.018298782,
-0.021651827,
0.016570276,
-0.0102605745,
0.0018860872,
-0.017506009,
-0.016128402,
-0.012827343,
-0.011729156,
0.025342776,
-0.004051595,
0.031373054,
0.00009051716,
0.004707908,
-0.0015051333,
-0.0036064717,
-0.04405744,
0.012008577,
-0.014126972,
-0.024991876,
0.016687242,
-0.024303071,
-0.009045421,
-0.0075183567,
0.0055396706,
0.01666125,
0.01118981,
0.02690233,
-0.012905321,
-0.025901616,
0.012112547,
0.018194813,
0.026850345,
-0.021638831,
0.010546493,
0.019949313,
0.0051790234,
-0.025459742,
-0.0151016945,
-0.0015774253,
0.0018682174,
0.01595945,
-0.008421599,
0.0022142436,
-0.005286243,
0.048918054,
-0.015088698,
-0.020105269,
-0.035999738,
-0.0068945345,
-0.020716093,
-0.008109688,
-0.011508219,
0.0032815645,
-0.009760218,
0.008343621,
-0.01339918,
0.008155175,
-0.0075248545,
0.008356618,
0.0027974525,
0.009389823,
0.0085775545,
0.016336342,
0.010975371,
-0.007921241,
-0.013880042,
-0.015673531,
-0.01866268,
0.0005080739,
0.007011501,
0.022418609,
-0.01816882,
0.012326986,
0.021352911,
0.0060042883,
0.00029729024,
-0.01592046,
-0.013041782,
0.040496454,
-0.020716093,
-0.0024952886,
0.004928845,
-0.002760088,
0.01252193,
0.016453309,
-0.0020631617,
-0.038079143,
-0.0027487164,
0.002490415,
0.016999153,
-0.0032994344,
-0.005081551,
0.0025261547,
-0.0054032095,
0.00775229,
-0.0071739545,
-0.038598996,
0.030801218,
-0.038624987,
-0.00449022,
0.026876338,
0.027890049,
0.031295076,
0.027318211,
0.010832411,
-0.024640976,
0.029787507,
-0.028955745,
0.029189678,
0.0024774186,
0.0042107995,
-0.011833127,
0.022457598,
-0.027032293,
-0.027188249,
0.002992397,
-0.016609265,
-0.004321268,
-0.020391187,
0.009240366,
0.0009422314,
0.008525569,
-0.008499577,
0.003128858,
0.011722658,
0.014256936,
0.002290597,
-0.010949378,
0.0063194484,
-0.0077457917,
0.0030427575,
0.018194813,
-0.016466305,
0.017272076,
-0.0024644225,
-0.02820196,
0.01907856,
-0.0109623745,
-0.014607836,
-0.012918317,
0.02830593,
-0.010955877,
0.008993436,
0.021170964,
-0.018571705,
-0.013568131,
0.03732536,
0.003528494,
0.0069985045,
-0.005338228,
0.012430956,
-0.0018535965,
0.022964453,
-0.019273505,
-0.021690816,
-0.0087530045,
-0.016817205,
-0.052271098,
-0.0033156797,
-0.009305347,
0.016258365,
0.0333225,
-0.04837221,
-0.015166676,
0.019416464,
-0.042705823,
-0.02364026,
-0.0029664042,
-0.012638897,
0.009181882,
0.027890049,
0.0040710894,
0.023354342,
-0.0019786858,
0.008057702,
-0.03243875,
-0.023796216,
-0.0065013967,
0.00033262392,
0.010377541,
0.020144258,
-0.038495027,
-0.005984794,
0.025849631,
-0.0076483195,
-0.025355771,
0.023809211,
-0.019962309,
0.026122553,
-0.012456949,
0.017129116,
0.00053447264,
0.0065436345,
0.021612838,
-0.02518682,
0.0131002655,
0.0017252581,
0.0034602634,
-0.020170249,
0.012255506,
0.000121027995,
-0.01076743,
0.008239651,
-0.024731949,
-0.042289943,
0.008740008,
-0.00361297,
0.0033205533,
0.027968027,
-0.012586911,
0.016648253,
-0.00715446,
-0.01259341,
-0.007823769,
-0.022899471,
0.0033757875,
0.008304632,
-0.008122684,
-0.0011810383,
0.005945805,
-0.0022776006,
-0.020716093,
0.006251218,
0.003749431,
-0.0075573456,
-0.020664109,
-0.018714665,
-0.014646824,
0.021521864,
-0.028331922,
-0.010669958,
0.0013629864,
-0.041432187,
-0.010702449,
-0.00020438705,
-0.0036909478,
-0.029943462,
0.019468449,
-0.018857624,
-0.0019965558,
-0.016479302,
-0.014672817,
-0.0340243,
-0.017415036,
0.029475596,
0.18059652,
-0.014880758,
-0.013724087,
0.016895182,
0.02455,
-0.017532002,
0.019793358,
-0.004188056,
-0.02027422,
0.00070261216,
0.00638443,
0.010910389,
-0.009617258,
0.007823769,
0.02328936,
-0.029631551,
-0.021664822,
-0.0099096745,
-0.014061991,
0.02248359,
0.0076028323,
-0.01199558,
0.0010388913,
-0.011482227,
0.029553574,
0.0028283186,
0.0047858856,
0.0135941245,
0.004191305,
0.01118981,
-0.015088698,
0.012534927,
0.011709661,
-0.012041067,
0.0021996228,
0.021417893,
-0.008869971,
0.019312494,
0.007849762,
0.003980115,
0.016427316,
0.011813632,
-0.021053998,
-0.013373188,
0.015335628,
-0.001694392,
-0.01003314,
-0.0022321136,
-0.023978164,
-0.018909609,
-0.034154262,
0.025758656,
-0.028046004,
0.044135418,
0.0002729222,
0.0100136455,
0.018688671,
0.0052212616,
0.027240233,
0.019494442,
-0.010845408,
-0.0032263303,
-0.023796216,
0.008746507,
-0.008986938,
0.027890049,
-0.018259794,
-0.00030845893,
0.004093833,
-0.009903177,
0.0033059325,
-0.015686527,
-0.0050523095,
-0.010059132,
-0.0017626225,
-0.0011388003,
0.037585285,
0.0023409575,
0.0106114745,
0.021898756,
0.0072064456,
-0.005572161,
-0.022678534,
0.0064559095,
-0.013880042,
-0.03774124,
0.039924618,
-0.0078107733,
-0.030099418,
-0.020664109,
0.007921241,
-0.0028819283,
-0.008142179,
-0.01385405,
0.012210019,
0.0034635125,
-0.019767364,
-0.009942166,
-0.040106565,
-0.023601271,
-0.016102409,
0.056351934,
0.0095587745,
0.024225093,
0.013984013,
0.016154394,
-0.00018072972,
0.005432451,
0.0037786728,
-0.009324841,
0.020430176,
-0.026044575,
0.016492298,
0.004587692,
-0.018805638,
0.005019819,
0.023731234,
-0.041198254,
0.026980307,
0.013516147,
-0.022457598,
-0.015972447,
-0.003268568,
0.016193382,
-0.008038208,
-0.006098511,
-0.008369613,
0.0035349922,
-0.0071674567,
-0.026980307,
0.013158749,
-0.016375331,
0.001806485,
-0.001697641,
0.018571705,
-0.035791796,
-0.004967834,
-0.016401324,
-0.038313076,
0.022912467,
0.0068555456,
-0.010429527,
0.0051335366,
-0.010780427,
0.01831178,
-0.0005259438,
0.002441679,
0.0052667484,
-0.009747221,
0.002314965,
0.0029469097,
-0.011033854,
0.0060692695,
-0.014010006,
0.024056142,
-0.02378322,
-0.02609656,
-0.016089413,
0.012197022,
0.008246149,
-0.024757942,
0.017025147,
0.026408471,
-0.007089479,
0.0077327956,
0.020339202,
-0.1620898,
0.011391252,
0.0068945345,
-0.018688671,
0.008941451,
0.025238805,
0.008246149,
-0.012073558,
0.002823445,
0.012054063,
0.011202806,
-0.002711352,
-0.035064004,
-0.010202091,
-0.009929169,
-0.0082266545,
-0.021833776,
0.029839493,
0.026200531,
0.017454024,
0.02027422,
-0.0057118717,
0.036857493,
-0.021599842,
0.030671256,
0.020001298,
0.0113132745,
-0.0041848067,
-0.011085839,
-0.017596982,
-0.00039841767,
-0.00014773132,
0.019910324,
-0.017635971,
0.00406784,
0.027344204,
-0.016687242,
-0.01831178,
-0.0027032292,
-0.0029469097,
0.03742933,
0.02931964,
0.009357332,
0.018402753,
-0.009935668,
0.047852356,
-0.0055656633,
-0.03644161,
0.009721229,
0.01662226,
0.0019104553,
0.0029972706,
0.00306875,
0.0076483195,
0.04689063,
-0.0099096745,
-0.012983299,
0.0270063,
-0.019845342,
-0.008389108,
-0.020313209,
-0.030541293,
0.029501589,
0.0034277728,
0.009402819,
-0.006836051,
-0.03314055,
0.0047793873,
-0.022626549,
-0.006212229,
-0.015790498,
-0.01501072,
0.01375008,
0.0048248745,
0.016141398,
0.014010006,
-0.0004617746,
0.002097277,
0.023042431,
0.003616219,
-0.002981025,
0.0035934756,
0.0035902264,
-0.009474299,
-0.0028526867,
-0.0016505294,
-0.00092679827,
0.03324452,
0.0030671256,
-0.0009341087,
0.016336342,
-0.0050977967,
0.003062252,
-0.016440313,
0.022106698,
0.0133471945,
0.0051400345,
0.017557994,
-0.0017707451,
-0.009565273,
0.022171678,
-0.027968027,
-0.016323347,
0.0013776072,
0.035583854,
-0.0065566306,
-0.018909609,
0.01631035,
0.04837221,
0.01550458,
-0.019247513,
-0.0069855084,
-0.005253752,
0.024095131,
-0.00007696243,
0.011625186,
-0.0112223,
-0.0032117094,
0.02153486,
-0.016518291,
0.06290206,
-0.0053284806,
-0.0005864578,
0.011384754,
-0.0029371625,
-0.015036713,
-0.12320487,
-0.0068620434,
0.019858338,
0.0016318472,
0.0001509804,
0.031658974,
-0.014152965,
0.04239391,
-0.0042010522,
0.045591,
-0.022275649,
-0.014178958,
0.0036876986,
-0.020859053,
-0.015673531,
0.025017867,
0.0029875233,
-0.00978621,
-0.008350119,
0.04096432,
-0.0016034179,
-0.00501657,
0.012021572,
-0.019767364,
0.019689387,
-0.020222235,
-0.03152901,
0.00901293,
-0.0036714533,
0.011722658,
0.000517415,
-0.040756382,
0.0097342245,
-0.011670672,
-0.020183247,
-0.013035283,
0.01536162,
-0.010760932,
0.027396189,
0.007830268,
-0.007368899,
0.00022337382,
0.011066345,
0.01595945,
0.019273505,
-0.0049255956,
-0.007817271,
0.0044739745,
-0.014841769,
-0.0012785106,
-0.013906036,
-0.013893039,
-0.036675543,
-0.0039021375,
-0.007667814,
-0.008304632,
0.01585548,
-0.011670672,
-0.020378191,
0.016076416,
0.0029875233,
0.003525245,
-0.0064656567,
-0.00768081,
0.0025407756,
-0.03100916,
-0.004545454,
-0.035999738,
-0.0047339005,
-0.026161542,
-0.031762943,
0.03181493,
0.010091623,
-0.0012614529,
-0.018272791,
0.0075703417,
-0.026460456,
-0.025095845,
0.02504386,
-0.008116186,
-0.021118978,
-0.009818701,
0.015192669,
-0.038650982,
0.027838062,
0.008759502,
-0.010929883,
-0.016739227,
0.0053674695,
-0.03202287,
-0.01515368,
0.019624405,
0.015556565,
-0.0009332964,
-0.014698809,
-0.0065858723,
-0.00023251184,
-0.015023717,
0.016739227,
-0.005848333,
-0.014113976,
-0.035193965,
-0.038521018,
-0.014815776,
-0.00044024948,
-0.0094548045,
-0.0017057636,
0.0029014228,
0.016895182,
0.010923386,
-0.008376112,
0.007544349,
-0.0039963606,
0.005153031,
-0.009877184,
-0.004756644,
-0.020807069,
-0.021716809,
0.013906036,
-0.0040223533,
0.03363441,
0.020365193,
0.007882252,
-0.00011554518,
0.007368899,
0.017726947,
-0.009006432,
-0.01420495,
-0.02062512,
0.000632351,
-0.028046004,
-0.015517576,
0.010052634,
-0.006472155,
-0.0029274153,
0.024498016,
-0.022418609,
-0.032672685,
0.033088565,
0.030047433,
0.023380334,
0.029293649,
-0.021495871,
-0.0066670994,
-0.012586911,
0.016921176,
-0.010338552,
0.016518291,
-0.033088565,
0.008213658,
0.016752224,
-0.00036389625,
0.04267983,
0.010988367,
0.029189678,
-0.00012153566,
-0.0064884,
0.008993436,
-0.0049580866,
0.0045129634,
0.013529142,
-0.02188576,
0.03433621,
0.029631551,
0.012197022,
-0.007882252,
-0.015413606,
-0.018649682,
-0.013867047,
-0.011124828,
0.00046624208,
-0.026070567,
-0.014633828,
0.01627136,
0.00827864,
-0.007966729,
0.018467735,
-0.0020046784,
-0.00005213748,
-0.023705242,
-0.0007785593,
0.022574564,
0.012788354,
0.010923386,
-0.005780102,
0.03282864,
0.01922152,
-0.0037624273,
-0.02097602,
-0.0048866067,
-0.0009032425,
0.018051853,
-0.007063486,
0.013516147,
-0.004893105,
0.022249656,
0.019104553,
0.025407756,
-0.00043009612,
0.0010819415,
-0.0024010655,
0.009708232,
-0.0013832931,
0.0061667417,
0.012495938,
-0.023029434,
-0.0032783153,
0.0036552078,
-0.036805507,
-0.021092987,
-0.008902462,
0.01280135,
0.007765286,
-0.0011729156,
0.0016350964,
-0.028149974,
-0.020040287,
0.008187666,
-0.009194879,
-0.016934171,
-0.005429202,
0.016882187,
0.014425887,
0.006351939,
0.009019429,
-0.005812593,
0.036909476,
-0.01245045,
0.012911819,
-0.018441742,
0.022821493,
-0.0012850086,
0.013568131,
0.018818635,
-0.012197022,
-0.007498862,
0.008369613,
-0.007921241,
0.0060205334,
-0.009324841,
-0.007791279,
0.07595035,
0.029735522,
-0.017687958,
0.017882902,
-0.029735522,
0.04660471,
-0.006598869,
0.023393331,
-0.012534927,
-0.05008772,
0.033582427,
-0.049515884,
0.006888036,
-0.039586715,
-0.030905189,
0.019494442,
0.007934238,
0.020209238,
-0.01585548,
-0.0017934886,
0.00564689,
-0.0059295595,
-0.0046071867,
0.02237962,
-0.024627978,
0.0009422314,
0.05221911,
0.029943462,
0.0098057045,
-0.019520435,
0.016388327,
-0.023133405,
-0.029475596,
-0.0012663265,
0.006394177,
-0.011878613,
-0.0030898692,
-0.0238482,
0.008934952,
0.021521864,
0.028461885,
-0.020534147,
-0.0035447394,
-0.012885827,
0.0022191172,
-0.0077327956,
-0.0032653192,
-0.0073818956,
-0.011794138
] |
Deinococcus spp. are renowned for their amazing ability to recover rapidly from severe genomic fragmentation as a result of exposure to extreme levels of ionizing radiation or desiccation. Despite having been originally characterized over 50 years ago, the mechanism underlying this remarkable repair process is still poorly understood. Here, we report the 2.8 A structure of DdrB, a single-stranded DNA (ssDNA) binding protein unique to Deinococcus spp. that is crucial for recovery following DNA damage. DdrB forms a pentameric ring capable of binding single-stranded but not double-stranded DNA. Unexpectedly,
|
[
-0.035058454,
0.008387715,
-0.010327031,
-0.04224009,
-0.038731504,
0.033907197,
-0.0010176271,
0.009518411,
-0.010505201,
-0.002401874,
-0.0031402532,
0.020791115,
0.013376486,
0.022134246,
-0.003611377,
0.007613358,
0.02702708,
0.021202277,
-0.0032927261,
0.00061374565,
-0.028287977,
-0.006397003,
-0.0034417724,
0.011992238,
0.0101488605,
0.0049545076,
-0.004135609,
-0.025944352,
0.0056123678,
0.009155218,
0.0033938035,
-0.007839497,
-0.023998182,
-0.012465076,
-0.011498843,
-0.01885865,
0.005502724,
0.0012172122,
0.01128641,
-0.020160666,
-0.006438119,
0.0018570838,
0.004025966,
0.0054855924,
0.008881109,
-0.014747027,
0.013472423,
-0.012663804,
0.014000081,
-0.011724982,
0.022367237,
0.015500825,
-0.02971334,
0.01369171,
-0.0060646464,
-0.0063010645,
0.012746036,
0.0009208326,
0.0044850972,
-0.025368724,
-0.007990257,
-0.007174785,
-0.020188076,
0.006472382,
-0.013081819,
0.0070000407,
0.020928169,
0.0037415784,
0.0034212144,
0.008881109,
0.046982165,
0.026752971,
0.0073735137,
-0.0051498096,
0.001186375,
-0.025944352,
-0.007003467,
0.012931059,
0.007880614,
0.007812087,
0.021846432,
-0.01632315,
-0.0012043634,
0.0037724157,
0.023107331,
-0.0109780375,
-0.029302178,
0.004437128,
-0.014363275,
-0.003930028,
0.021887548,
0.03201585,
0.016199801,
0.013246284,
-0.025368724,
0.01194427,
0.01680284,
0.023354027,
-0.006033809,
-0.03429095,
-0.019735798,
0.002886703,
0.0038477953,
-0.015747523,
-0.020996697,
0.008744055,
0.013410749,
-0.015911987,
0.011272704,
-0.011402906,
-0.012814564,
0.02209313,
-0.0013559796,
-0.051696826,
0.0544105,
-0.008572738,
0.029877806,
-0.01007348,
0.005201205,
-0.015953103,
0.030727541,
0.018488605,
0.012835122,
-0.037744712,
0.021051519,
0.00941562,
-0.01551453,
0.0011272704,
0.02735601,
0.010464084,
-0.010313325,
0.0260677,
0.021956075,
-0.0014699058,
-0.016062748,
0.012458223,
-0.008977047,
-0.0140206395,
-0.010621697,
-0.035880778,
0.02355961,
0.015720112,
-0.034373183,
-0.038046233,
0.015651584,
0.01748811,
0.02421747,
0.0051943525,
0.00602353,
0.0073049865,
-0.00840142,
-0.016569847,
-0.0033852377,
0.0032567494,
0.000118744574,
0.01748811,
-0.0043446166,
0.011416611,
-0.03294782,
-0.010649107,
0.0007272436,
-0.002091789,
-0.00018405945,
-0.023573315,
0.01343816,
0.036428995,
-0.028123513,
-0.00408764,
0.00009791877,
-0.008593296,
-0.012636393,
0.019530216,
-0.027767172,
0.011779805,
-0.00627708,
0.0313854,
0.011450875,
0.019722093,
-0.020064728,
0.0045570508,
-0.0035120128,
-0.013561509,
0.035414793,
0.016994715,
-0.017460698,
-0.00807249,
0.024203764,
-0.0010390418,
-0.006743064,
-0.011416611,
0.002614308,
-0.018776419,
0.0017354483,
-0.0038649272,
-0.62672126,
-0.018776419,
-0.0063079176,
-0.012766594,
-0.009395062,
0.028973248,
0.011341231,
0.013143494,
-0.01602163,
0.02971334,
0.003205354,
-0.013259989,
-0.0046906783,
-0.027589,
-0.033715323,
-0.023655547,
0.01916017,
0.0029518039,
0.024340818,
-0.0018450916,
-0.017899273,
0.0017542932,
-0.02789052,
0.00689725,
-0.015596762,
0.0015307235,
0.010868395,
-0.00799711,
0.0063010645,
0.02042107,
-0.049037978,
0.016364265,
0.0048380117,
0.0070240255,
0.044460367,
-0.00580767,
0.014431803,
0.030563077,
0.032591477,
0.03360568,
-0.00008753264,
0.013472423,
0.019982496,
-0.0002413438,
-0.00675677,
0.022970276,
0.010566875,
0.015089663,
0.0074351877,
0.0006617146,
0.00006643914,
0.021914959,
-0.004348043,
0.022655051,
0.03034379,
0.013876733,
0.019228699,
-0.017734807,
0.029165125,
0.0041390355,
0.010196829,
0.03237219,
0.0039060435,
-0.030563077,
-0.017529227,
-0.0027667808,
-0.027191544,
0.014514035,
0.037443195,
-0.019242404,
0.036511227,
0.024518989,
0.03631935,
0.0021654556,
-0.0051737945,
0.026807792,
-0.010902658,
0.006468956,
0.0020403937,
0.04021169,
-0.0051875,
-0.010470937,
-0.025478367,
0.009210039,
0.036182296,
-0.011238441,
0.009223744,
0.031577278,
-0.008757761,
-0.013547803,
0.010306472,
0.02257282,
0.003436633,
-0.016885072,
-0.0009482434,
0.027109312,
-0.007051436,
-0.016117569,
0.005064151,
-0.013917849,
-0.019831736,
-0.014952608,
0.012417106,
0.0058933287,
-0.00024112964,
-0.002866145,
-0.013492981,
-0.0010870107,
0.04522787,
-0.014719616,
-0.0017714249,
-0.011265852,
-0.014472919,
0.011786657,
0.01255416,
-0.016336855,
0.016569847,
0.022915455,
0.005382802,
-0.019598745,
0.0022905176,
-0.0060063982,
0.01047779,
-0.023820013,
0.0024772538,
0.013849323,
0.022285005,
-0.019242404,
-0.00733925,
-0.022613935,
0.0035942453,
0.006660832,
0.012444518,
-0.01895459,
0.0179678,
0.0070651416,
0.00009925719,
-0.0015658437,
0.01047779,
-0.037552837,
-0.03423613,
0.0012180688,
0.015213011,
-0.0074351877,
-0.037443195,
0.0032190594,
-0.01981803,
-0.0027873388,
0.00007596869,
-0.0013148633,
0.026355514,
-0.00053108484,
-0.021887548,
0.015733818,
-0.009854194,
-0.015459709,
-0.025519483,
-0.029000659,
-0.0024738275,
-0.008737203,
0.012841974,
-0.023751484,
-0.023011392,
-0.005598662,
-0.00051566627,
-0.0415,
0.022682462,
0.006582026,
-0.015651584,
-0.016597258,
0.0022305564,
0.0007537978,
-0.013760237,
0.0043788804,
0.017830746,
0.035825957,
-0.011087681,
-0.00019904974,
-0.0024858196,
-0.011916859,
-0.020160666,
-0.026136227,
-0.010642255,
-0.006235964,
0.02457381,
0.004166446,
0.02723266,
-0.009196334,
0.024834212,
0.0080382265,
-0.00091654964,
0.008517915,
-0.017912978,
0.007853203,
-0.0021671688,
-0.026711855,
0.011300115,
0.0068218703,
-0.012519897,
0.032838177,
0.004724942,
-0.025848413,
0.014897786,
-0.028479854,
0.018735303,
-0.017049536,
0.006146879,
-0.020462185,
0.018337846,
-0.01171813,
-0.003457191,
-0.017118065,
-0.0062291115,
0.00065743166,
-0.010011806,
0.034373183,
-0.0024532694,
0.015404887,
-0.002295657,
0.002914114,
-0.012965323,
0.029905217,
0.018050032,
0.0089290785,
-0.024560105,
-0.0041184775,
0.0005507864,
0.018461194,
0.013164052,
0.0011169914,
-0.0025423546,
0.014102872,
0.0067156535,
-0.0065340567,
-0.0023076492,
0.010854689,
0.0029295324,
-0.0064244135,
0.044432957,
-0.0058693443,
-0.011354936,
0.0044199964,
0.014884081,
0.00021350467,
0.010142007,
0.0032019278,
0.013253137,
0.018913474,
-0.013342222,
0.023326617,
-0.033496033,
0.005238895,
-0.04262384,
0.0026211606,
-0.0015726964,
-0.008956489,
0.012828269,
0.029795572,
0.031166114,
-0.005160089,
0.006297638,
0.017378466,
0.03766248,
-0.013054408,
0.036867566,
-0.0120127965,
-0.00022356959,
0.0037141675,
-0.0146785,
0.014582562,
-0.008963342,
-0.011985386,
-0.011608487,
-0.0110602705,
0.011231588,
-0.0033201368,
0.0054684607,
0.0049613602,
-0.0032875866,
-0.014870375,
-0.004882554,
-0.03667569,
0.030097092,
0.02771235,
0.0017799909,
-0.016103864,
-0.018982,
0.007818939,
-0.002905548,
0.023984477,
0.01434957,
0.028891016,
0.013164052,
0.03294782,
-0.02047589,
-0.0071816375,
0.022339826,
-0.028425032,
0.005972135,
0.008216397,
0.016268328,
0.0026605637,
-0.0059789876,
-0.010313325,
0.04385733,
0.00434119,
0.00675677,
0.008469947,
-0.0013516966,
-0.0074420404,
-0.003186509,
-0.0089907525,
0.0021226262,
-0.0036182296,
-0.012478781,
-0.0015607042,
-0.013671152,
0.0008985613,
0.0038409426,
0.01683025,
-0.0265748,
-0.019955086,
0.021010403,
0.003205354,
0.018707892,
0.033167105,
-0.025560599,
0.012862532,
0.017145475,
0.016885072,
0.008476799,
-0.038183287,
0.03700462,
-0.010916363,
0.015925692,
0.017912978,
0.0100666275,
0.0028592923,
-0.009230597,
0.02292916,
0.00802452,
-0.014089167,
-0.0245464,
0.016939893,
-0.016583553,
0.01237599,
0.014212516,
0.04753038,
0.027945342,
-0.012211525,
0.011827773,
0.020297721,
-0.00010011378,
-0.013657446,
-0.00850421,
0.020434774,
0.01814597,
0.025355019,
-0.0041938573,
-0.026670739,
-0.00511212,
0.0003372817,
0.01850231,
0.011217883,
0.022476882,
0.009477295,
0.007709296,
0.012478781,
0.016761724,
-0.011217883,
0.0048448644,
0.0030203308,
-0.021380449,
-0.02325809,
0.03067272,
-0.031166114,
-0.024436755,
-0.028342798,
-0.00029209667,
-0.017200297,
0.007078847,
-0.01700842,
-0.016391676,
0.0076270634,
-0.016213506,
-0.01700842,
0.016117569,
-0.0063250493,
0.0069794827,
-0.01698101,
-0.01434957,
-0.0015538514,
-0.032865588,
-0.0043446166,
-0.005160089,
-0.024998678,
-0.0260677,
-0.0012334874,
0.01548712,
-0.000018416651,
0.027780877,
-0.017474405,
0.0053314064,
-0.0033252763,
-0.0099021625,
-0.008737203,
0.011279557,
-0.023573315,
0.0047112363,
0.035688903,
0.003806679,
-0.020092139,
-0.03006968,
0.011889447,
0.023134742,
0.013712268,
-0.0053896545,
-0.0005936158,
-0.004927097,
0.0303712,
0.04457001,
0.031769153,
0.00048611395,
-0.011868889,
0.014897786,
-0.007572242,
-0.03292041,
-0.002614308,
0.013582067,
-0.0153226545,
-0.02627328,
0.0038991906,
0.0018365256,
0.003061447,
0.014664794,
-0.008511063,
0.0054855924,
0.000108786735,
0.019776914,
0.01913276,
0.00088485586,
-0.0068698395,
-0.017433288,
-0.00913466,
-0.0013294253,
-0.034482826,
0.028233156,
0.015733818,
0.00082189665,
-0.00018587969,
-0.007174785,
-0.035825957,
-0.019009411,
-0.023778895,
0.011334378,
0.019900262,
-0.008977047,
-0.016624669,
0.0033629662,
0.00030558792,
0.008613854,
0.015432297,
0.0069760564,
-0.013952113,
-0.014966314,
-0.008771466,
0.017542932,
0.0021123472,
-0.004892833,
-0.025834708,
-0.021997191,
0.016186096,
0.018214498,
-0.007496862,
-0.0132325785,
-0.0026074552,
-0.003844369,
-0.0050333138,
-0.02971334,
-0.04221268,
0.01131382,
-0.004210989,
0.04846235,
0.016556142,
0.05013441,
-0.0023127887,
0.013725974,
0.029932627,
0.012149851,
-0.006845855,
0.0005717728,
-0.017145475,
-0.018570838,
-0.004406291,
-0.015267833,
-0.015706407,
-0.0047146627,
-0.0359356,
0.020379953,
0.015473414,
0.004183578,
-0.044076614,
-0.00237275,
-0.039827935,
-0.011450875,
-0.023847423,
0.0014390686,
0.0019907115,
-0.0141851045,
0.0015075956,
0.030837184,
-0.030919418,
-0.0033047183,
-0.014130283,
0.038813736,
0.016227212,
0.009861046,
0.01343816,
0.022723578,
-0.010635402,
-0.011471433,
-0.01197168,
-0.007928583,
0.031522457,
-0.0007803521,
0.012561013,
0.013575214,
-0.0008925652,
0.008565885,
-0.023011392,
-0.008305482,
-0.041664463,
-0.011594782,
0.008456241,
-0.008826287,
-0.006842429,
-0.023038803,
-0.04388474,
0.0035771134,
-0.010484642,
-0.020681472,
0.02442305,
0.008511063,
-0.023874834,
0.023669252,
0.0035771134,
0.016487615,
-0.020352542,
0.018762713,
0.024518989,
-0.011245294,
-0.024710864,
-0.019119054,
0.010265356,
-0.014281043,
0.029822985,
0.016761724,
-0.029877806,
-0.037498016,
-0.00050238916,
-0.0073940717,
-0.027575295,
-0.01434957,
0.0154460035,
-0.0014253632,
0.008559032,
0.008476799,
0.0065409094,
-0.0028421604,
0.0026571373,
-0.01766628,
0.015391181,
0.0121361455,
-0.012999587,
-0.013143494,
-0.008257513,
-0.0028044707,
0.028616907,
-0.01925611,
-0.013602625,
-0.0038101054,
-0.01781704,
-0.016076453,
-0.012828269,
-0.008147869,
0.02756159,
-0.004481671,
0.0035291445,
0.0031453928,
0.0076270634,
-0.010299619,
-0.0020797967,
-0.007942288,
0.03963606,
-0.01961245,
-0.007147374,
-0.0017988358,
0.007572242,
-0.014514035,
0.023052508,
-0.018707892,
0.020174371,
-0.02753418,
-0.000069758426,
0.013801353,
0.012766594,
0.0014784717,
-0.00642784,
-0.010436674,
0.000832604,
-0.019927673,
-0.02902807,
0.017693691,
-0.046653233,
-0.020393658,
-0.00057434256,
0.022476882,
0.032618888,
-0.009676023,
0.013609477,
-0.003806679,
0.017899273,
-0.01736476,
0.020722589,
0.0063764444,
0.012478781,
-0.03338639,
0.0054581817,
0.0077024433,
-0.03697721,
0.0070925523,
-0.0015247274,
-0.00941562,
-0.017118065,
-0.03070013,
0.01826932,
0.002616021,
-0.030179325,
0.020092139,
-0.020092139,
0.008586443,
-0.0061640106,
-0.044953763,
0.039142665,
0.020914463,
0.005865918,
-0.005166942,
-0.011457727,
-0.022024602,
-0.010320178,
-0.014445508,
-0.0015958243,
0.0053793755,
-0.0066368473,
-0.022243889,
-0.010299619,
-0.007798381,
-0.0008090478,
-0.011937417,
-0.024861623,
-0.015418592,
0.0005053872,
0.0041287565,
-0.007051436,
-0.0004826876,
0.001215499,
-0.001791983,
0.00482088,
-0.0048277327,
-0.0073255445,
0.008305482,
-0.031467635,
-0.031412814,
-0.008415125,
-0.0072844285,
0.03530515,
0.008696086,
0.008469947,
-0.013431307,
0.0075585367,
-0.016583553,
-0.00598584,
-0.0046803993,
0.028562086,
0.02107893,
0.023710368,
-0.005345112,
0.025629127,
-0.001346557,
0.02968593,
0.024107825,
-0.01346557,
0.012341727,
0.0089839,
0.022312416,
0.004550198,
-0.051861294,
-0.006400429,
0.035469614,
0.018036326,
0.007647622,
0.016240917,
0.017186591,
0.009840488,
0.003998555,
0.0023247811,
0.0090935435,
0.029329589,
-0.0057494217,
-0.011841479,
-0.031111293,
0.0032070673,
0.010991743,
-0.014747027,
-0.00004834371,
-0.0021431844,
0.015884576,
-0.0014510609,
-0.011341231,
-0.018050032,
-0.0035000204,
-0.035195507,
0.013938407,
0.0035428498,
0.012437665,
0.03335898,
0.0013902431,
-0.01895459,
-0.0077298544,
-0.02292916,
-0.036237117,
-0.007853203,
0.002545781,
-0.017652575,
-0.0061537316,
-0.017789628,
0.00412533,
-0.009751403,
0.0069966144,
-0.007291281,
-0.01361633,
-0.03270112,
0.029192535,
-0.009292272,
0.014239927,
-0.017446993,
-0.0040807873,
-0.023107331,
0.0030049123,
0.0042486787,
0.007880614,
-0.022476882,
0.0021346183,
0.0027273777,
-0.03270112,
-0.0232855,
0.009470442,
0.01047779,
-0.015130779,
0.0049339496,
0.19297224,
-0.016432794,
0.01361633,
0.029932627,
-0.00733925,
-0.010546317,
0.0028849898,
-0.025875824,
-0.016816545,
0.011930564,
0.015665289,
0.004618725,
-0.011190471,
0.00036790475,
0.0184749,
0.012608982,
-0.023121037,
0.0023453392,
-0.021928664,
-0.016295739,
0.01548712,
-0.009504706,
0.0015684135,
-0.0031453928,
0.012835122,
-0.0071405214,
-0.033907197,
-0.022189068,
-0.008894814,
0.02355961,
-0.012944764,
-0.022216478,
0.009168923,
-0.00609891,
0.013828764,
-0.0065100724,
0.0013302818,
-0.0164465,
-0.020681472,
-0.000109643326,
-0.008045079,
-0.008613854,
-0.0061742896,
-0.026848909,
-0.021572324,
0.012088177,
-0.014842965,
-0.0047043837,
-0.015788639,
0.0062702275,
-0.036154885,
0.010532612,
0.009120954,
0.018008916,
0.016967304,
-0.021024108,
0.016885072,
-0.01584346,
-0.012643246,
0.03530515,
-0.020667767,
0.023449965,
-0.039115254,
0.035113275,
-0.009573232,
0.019804325,
-0.019434279,
0.046735466,
0.02905548,
-0.013328517,
-0.0075585367,
-0.030261558,
-0.025327608,
0.0031590983,
-0.029768161,
-0.011067123,
0.010738193,
0.020791115,
0.04689993,
0.013013292,
-0.007647622,
-0.0070103197,
-0.023216974,
0.01781704,
0.0152404215,
-0.02421747,
0.007572242,
0.0013200028,
-0.018844945,
-0.012471928,
0.011149355,
0.0033578267,
-0.0099638365,
0.00255606,
0.0088674035,
-0.010279061,
-0.007174785,
0.0150759565,
-0.0042178417,
-0.003291013,
-0.026766676,
0.07362549,
-0.0029672224,
0.009319683,
-0.023395143,
0.008607001,
-0.016624669,
0.017652575,
-0.0018245335,
-0.004190431,
0.001713177,
-0.0109574795,
0.025848413,
-0.014801849,
0.010176271,
0.033139694,
0.030316379,
-0.032125495,
0.03102906,
-0.005752848,
0.0035034467,
-0.039964993,
0.00941562,
0.029960038,
-0.03991017,
-0.0020352541,
-0.007359808,
0.011649603,
-0.012238936,
-0.02196978,
-0.03303005,
-0.02260023,
0.018639365,
0.0021654556,
0.017981505,
0.03102906,
0.017351056,
-0.024847917,
-0.018488605,
-0.0011015728,
0.0046941047,
-0.005081283,
0.014212516,
0.007949141,
-0.0021448976,
-0.022230184,
0.013383338,
0.0054239184,
0.003991702,
0.013705416,
-0.032454424,
-0.005482166,
-0.0053348327,
-0.0040636556,
-0.020722589,
-0.01599422,
-0.028945837,
-0.043418758,
-0.0037312994,
0.0074694515,
-0.02343626,
-0.0032464704,
0.012355432,
-0.012355432,
-0.022696167,
0.0045262133,
-0.17433289,
0.016090158,
0.0067499173,
-0.03601783,
0.027849404,
0.0052834377,
0.016103864,
0.017104357,
0.006407282,
0.00733925,
0.0076544746,
0.03525033,
-0.035880778,
-0.036483817,
-0.014116578,
0.008051932,
0.0024926725,
0.02510832,
0.024683453,
-0.005684321,
0.0089290785,
-0.0143906865,
-0.0069897617,
-0.02229871,
0.0021757346,
0.012286905,
0.013294253,
0.011731836,
0.007167932,
-0.012835122,
-0.013582067,
-0.01733735,
0.026149932,
-0.03004227,
-0.011409759,
-0.0075448314,
0.013582067,
0.0049510812,
0.00035205786,
0.02735601,
0.00434119,
0.019009411,
0.006873266,
-0.036182296,
0.0032481835,
0.026465157,
0.00441657,
-0.008449389,
0.022394648,
-0.012800858,
0.020462185,
-0.026122522,
0.010018659,
0.022709873,
0.020654062,
0.0065306304,
0.0030443154,
0.017844452,
-0.0045570508,
-0.00028460153,
-0.00078206527,
-0.0151856,
0.040156867,
-0.023449965,
0.010909511,
-0.025971763,
-0.021558618,
0.0017714249,
-0.025971763,
0.0049442286,
-0.0179678,
-0.0080587845,
-0.000660858,
0.0010570302,
-0.0022031455,
0.012889943,
-0.004152741,
0.010607991,
-0.01647391,
-0.032427013,
-0.008380862,
0.04648877,
-0.0075379782,
-0.022216478,
-0.008243808,
-0.019352047,
-0.008874256,
0.016926188,
0.0090113105,
0.005372523,
0.0049442286,
-0.020585533,
0.011951122,
0.002508091,
0.016693195,
0.018392667,
-0.012889943,
0.0037347258,
-0.0074009243,
-0.0005944724,
-0.0050744303,
0.0017534366,
-0.01346557,
0.03889597,
0.0080587845,
0.0040396713,
-0.00034113636,
-0.0046598413,
0.036757924,
0.0033749586,
-0.004916818,
-0.0031128426,
0.016556142,
0.028781373,
0.006886971,
0.041116245,
-0.015774934,
0.0065443357,
-0.013609477,
-0.015144484,
0.08003963,
-0.0014793283,
-0.03862186,
-0.0059412974,
-0.0048757014,
-0.025807297,
-0.13069484,
0.0064997934,
-0.007058289,
0.0131914625,
0.0048071747,
0.0031299742,
0.009477295,
0.019900262,
-0.019269815,
0.0059001814,
-0.0056089414,
-0.0045947405,
-0.023216974,
0.0099432785,
-0.00029059764,
0.012088177,
0.0052902903,
-0.013746532,
-0.005286864,
0.01733735,
-0.010621697,
-0.003350974,
-0.005005903,
-0.008394567,
0.0028490133,
0.00093796436,
-0.013122935,
0.014980019,
0.020352542,
0.0222713,
0.0057151583,
-0.006266801,
0.016912483,
-0.0076407692,
-0.021476386,
-0.001748297,
-0.02720525,
-0.031248348,
0.037086856,
-0.020941874,
-0.004101346,
0.010285914,
0.0023453392,
-0.0048585697,
0.007736707,
0.0061811423,
-0.0019478821,
0.024943857,
0.00981993,
-0.009881604,
-0.033687912,
-0.0036250823,
-0.031961028,
-0.008977047,
0.02839762,
-0.035579257,
0.0058453595,
0.011293262,
-0.016885072,
-0.01212244,
0.0013988089,
0.0026794088,
-0.0048757014,
0.0120744705,
0.017392172,
-0.024998678,
-0.021805316,
0.008435683,
0.021120045,
-0.044405546,
0.0099227205,
0.0038409426,
-0.02424488,
-0.014130283,
-0.012889943,
0.013383338,
-0.03360568,
-0.020229192,
-0.0060303826,
-0.023381438,
-0.003378385,
-0.009696581,
0.015884576,
-0.029768161,
0.016528731,
0.004337764,
0.00073024165,
-0.0030837185,
0.0142673375,
-0.012622688,
-0.015555646,
0.0245464,
-0.020366248,
-0.013739679,
-0.01814597,
0.040458385,
-0.011087681,
-0.00825066,
-0.0035771134,
0.0015110221,
-0.028068691,
0.0036559196,
-0.058494713,
0.021188572,
0.018584544,
-0.009278567,
0.022353532,
-0.025546893,
0.009833636,
0.0021020682,
0.001956448,
-0.0009405341,
-0.011471433,
0.0072364593,
-0.017405877,
-0.014980019,
-0.03727873,
-0.049339496,
0.03168692,
-0.0071131107,
0.035551846,
0.027959047,
-0.028054986,
0.007524273,
0.026794087,
0.01551453,
-0.01146458,
-0.0033526872,
0.0036970358,
0.0051258253,
-0.012423959,
-0.0022922307,
-0.0045262133,
-0.05049075,
-0.025176847,
-0.0024361375,
-0.01599422,
-0.018694187,
-0.013623183,
0.020599239,
-0.00387178,
0.027520474,
-0.023518493,
-0.045995373,
0.0046050195,
0.00039467314,
-0.0037621364,
0.0109780375,
-0.043418758,
0.012896796,
0.009511558,
-0.0250535,
0.030754952,
0.005351965,
-0.00066257117,
-0.040129457,
-0.018872356,
0.006712227,
0.003388664,
0.013225726,
0.002283665,
-0.015925692,
0.010930069,
0.012656951,
0.031440224,
0.00060089683,
0.012108735,
-0.013986376,
-0.004810601,
-0.00997069,
-0.0142673375,
-0.026012879,
-0.0111219445,
0.033221927,
0.013116082,
0.011094534,
-0.012211525,
-0.022010896,
-0.031056471,
-0.007359808,
-0.0026400057,
0.00040281072,
-0.010450379,
-0.005016182,
0.004601593,
0.01179351,
0.058659177,
0.008737203,
-0.00041565954,
0.03228996,
0.01951651,
0.012485634,
0.0022237035,
0.035085864,
0.005064151,
-0.0074009243,
-0.0005794821,
0.028589496,
-0.0037929737,
-0.014006934,
0.024464166,
0.006886971,
0.006527204,
-0.014472919,
0.0132120205,
-0.011581076,
-0.005643205,
0.019009411,
-0.0026691298,
-0.021147456,
-0.010285914,
0.018529722,
0.008977047,
-0.0036353613,
-0.011670161,
0.024272291,
-0.0049921977,
-0.01677543,
-0.010635402,
-0.010443526,
-0.009833636,
0.020366248,
0.017830746,
0.012060765,
0.00208151,
-0.001307154,
0.027246365,
0.024053004,
0.025601717,
-0.014514035,
0.0022511145,
-0.0075790947,
0.024080414,
-0.0027530752,
-0.024066709,
-0.015089663,
0.018337846,
-0.0009996387,
0.0041698725,
0.02047589,
-0.02941182,
0.08321928,
0.022052014,
-0.0109985955,
-0.0077298544,
-0.04193857,
0.011923712,
0.0075859474,
0.0055404142,
0.016843956,
-0.02095558,
0.034455415,
-0.030288968,
0.0089701945,
-0.012944764,
-0.005776833,
0.046132427,
0.00034392026,
0.013636888,
-0.022038307,
-0.0142673375,
0.021448975,
-0.0053348327,
0.012005944,
0.0055061504,
-0.012794006,
0.010217387,
0.0055404142,
-0.010799867,
0.023833718,
-0.023573315,
0.018200792,
-0.020407364,
-0.026780382,
-0.017529227,
0.0060098246,
0.0026451452,
-0.020325132,
-0.022285005,
0.0036045243,
0.020092139,
-0.0067944597,
0.004735221,
-0.011505696,
-0.020242898,
0.023751484,
0.0071405214,
-0.008997605,
-0.013328517,
0.010306472
] |
Background The catalytically active 66-kDa subunit of the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) consists of DNA polymerase, connection, and ribonuclease H (RNase H) domains. Almost all known RT inhibitor resistance mutations identified to date map to the polymerase domain of the enzyme. However, the connection and RNase H domains are not routinely analysed in clinical samples and none of the genotyping assays available for patient management sequence the entire RT coding region. The British Columbia Centre for Excellence in HIV/AIDS (the Centre) genotypes clinical isolates up
|
[
-0.019349514,
-0.013187975,
-0.020100432,
-0.007348256,
-0.0067850687,
0.008394176,
0.0074287117,
0.015219472,
-0.012665015,
-0.0012277823,
0.0036640712,
-0.009466914,
-0.01645312,
-0.008253379,
-0.002655027,
-0.008608724,
0.018585188,
-0.013596956,
0.00780417,
-0.029956212,
-0.038699027,
-0.00850145,
-0.005980515,
-0.0388063,
-0.009956351,
0.023694104,
0.0153803835,
-0.02464616,
-0.025262984,
-0.035480812,
-0.0022477217,
0.0066275103,
-0.016587213,
-0.031270318,
-0.009661348,
-0.003050599,
0.0013149423,
0.013221498,
0.012718651,
0.015206063,
0.022433637,
0.013523205,
-0.007991899,
0.008803157,
0.013020359,
0.0026701123,
0.016627442,
-0.00055648293,
-0.028829837,
0.013999233,
-0.0009093132,
0.012497399,
0.0073415516,
-0.006305689,
-0.0023130917,
-0.0063459165,
-0.0048507876,
0.011136363,
-0.0015160807,
-0.012416944,
0.00815281,
-0.00935964,
-0.02533003,
0.014844014,
0.009393163,
0.01803541,
0.006376087,
-0.0029600868,
0.0030455706,
0.0197652,
0.02669777,
0.0010258058,
-0.019724973,
0.0038484482,
0.03395216,
-0.018263366,
-0.025249574,
0.0070465486,
0.007475644,
0.01457583,
0.021199988,
-0.0034042674,
-0.014642876,
0.031350773,
0.013563433,
0.008025422,
0.004535671,
0.009949646,
0.012732061,
-0.013670707,
0.016278801,
0.02842756,
0.01698949,
0.029339388,
-0.031645775,
0.0050083464,
-0.0068454104,
0.022514092,
-0.010519538,
-0.02773028,
0.0017733702,
0.0009864162,
-0.009714984,
-0.007509167,
-0.021065895,
0.014186962,
0.0019946224,
-0.016882217,
0.0012118588,
0.0015546322,
-0.020945212,
0.028561654,
-0.026469814,
-0.019792018,
0.039476763,
0.0015118903,
0.027462097,
-0.0054575554,
-0.002494116,
-0.029285751,
0.002765653,
0.020261342,
0.01977861,
-0.032477148,
0.036124457,
-0.0051826662,
-0.017887909,
-0.007971785,
0.009527256,
-0.011049203,
0.029017568,
0.012638196,
0.00050326507,
0.016895626,
0.00029123164,
0.010304991,
-0.02915166,
-0.028213013,
-0.024310928,
-0.021977723,
0.01909474,
0.038404025,
-0.0059637534,
0.0039624264,
0.024310928,
-0.008394176,
0.02742187,
0.0013912073,
0.017552678,
-0.0054575554,
0.01871928,
-0.012316375,
0.0024522124,
-0.018665643,
0.00046429448,
0.026469814,
-0.02826665,
0.024874115,
-0.010720677,
-0.020140659,
-0.011411252,
-0.010646926,
0.015313337,
-0.0006536998,
0.025048435,
0.028722564,
0.009916123,
0.0055882954,
0.010191012,
-0.012678424,
0.00056444464,
-0.0020482594,
-0.024203654,
0.015165836,
0.02011384,
0.01386514,
0.0009696547,
0.009996578,
-0.017096763,
-0.022138633,
0.0061447783,
0.01820973,
0.025598213,
0.0044753295,
-0.02185704,
-0.0171504,
0.024458429,
-0.0022343125,
0.008012013,
-0.021132942,
-0.0077907606,
0.0034394667,
0.020395434,
-0.01749904,
-0.6324864,
-0.036446277,
-0.0028125853,
-0.018223139,
0.016922444,
0.0008100011,
0.025879808,
0.0059436397,
-0.01767336,
0.024458429,
-0.008863498,
0.01820973,
0.02480707,
-0.018169502,
-0.032664876,
-0.042453613,
-0.012551037,
-0.006315746,
0.0077438285,
-0.0011397842,
-0.02669777,
0.018518142,
-0.0055681816,
0.019108148,
0.014978106,
0.011297273,
0.021012258,
-0.00016908196,
-0.014079688,
0.009607711,
-0.004468625,
0.0031863675,
-0.012437058,
0.011920802,
0.04352635,
-0.0042842478,
0.014709922,
0.0340058,
0.019644517,
0.014079688,
0.007214164,
0.004086462,
0.005269826,
0.010499424,
0.005454203,
0.0026315607,
-0.008400881,
0.011927507,
0.00832713,
0.00019097672,
0.0014398157,
-0.015420611,
-0.010137375,
0.031055769,
-0.000940322,
-0.016868807,
0.012155464,
-0.025584804,
0.033067152,
-0.0012872858,
-0.007871216,
0.022125224,
0.0077103055,
-0.026040718,
-0.01647994,
0.0063928487,
-0.0009922828,
0.02290296,
0.002678493,
0.010191012,
-0.00047518947,
0.011793415,
0.000951217,
0.00052044564,
-0.009741804,
0.029366206,
-0.0034897514,
-0.014401509,
-0.005698921,
0.028534835,
0.0171504,
0.0026047423,
-0.028373923,
-0.003147816,
0.024927752,
0.0019493663,
-0.013308657,
0.012229214,
-0.0014683104,
0.0139590055,
0.014119916,
0.00081628666,
-0.0030254568,
-0.016117891,
-0.017405177,
0.017659951,
0.0044015786,
0.014267418,
-0.017431995,
-0.013281839,
-0.004019416,
-0.019215422,
0.010693858,
0.013570137,
0.030733949,
-0.01594357,
-0.022259317,
0.015366974,
0.055031467,
-0.021789994,
-0.02966121,
0.0015537941,
-0.011055907,
-0.0069258655,
-0.0032265952,
-0.031833503,
0.027354823,
0.0052530644,
-0.0012177255,
-0.03070713,
-0.0041568605,
-0.0077773514,
0.0073884837,
-0.00078863016,
0.007509167,
0.008856794,
0.01578266,
-0.0287762,
0.014656285,
-0.018759508,
0.008977477,
0.0021806755,
0.015863115,
-0.017740406,
0.0150049245,
0.022822505,
0.031136224,
0.0076030316,
-0.016909035,
-0.030438945,
-0.01647994,
-0.016037434,
-0.015568112,
0.0141065065,
-0.007227573,
-0.030170761,
-0.025598213,
-0.0023734332,
0.028856656,
0.010009988,
0.032986697,
0.009802145,
0.002349967,
0.018182911,
0.018933829,
-0.026040718,
-0.008803157,
-0.04406272,
0.009862486,
-0.01578266,
0.004622831,
0.002624856,
0.023506375,
0.0013677411,
0.00081712473,
-0.0022125223,
0.006657681,
0.0098423725,
-0.0054206797,
-0.05685512,
-0.004109928,
-0.013784685,
-0.014173552,
-0.0076968963,
0.012671719,
0.03245033,
-0.0030690369,
0.0074488255,
-0.014790378,
-0.0010358627,
-0.010874883,
-0.012906381,
-0.006164892,
-0.0029047737,
0.0072812103,
0.012691833,
0.021468172,
-0.010787723,
0.0026701123,
0.033871707,
0.0066543287,
0.0052396553,
0.000092136055,
0.009192025,
-0.006195063,
-0.0016702868,
0.01960429,
0.01543402,
0.012450467,
0.026590496,
-0.0031629014,
-0.0035232743,
0.017217448,
-0.019000875,
0.0012688481,
-0.017485632,
0.0070130257,
-0.018853372,
0.038967215,
-0.00062562426,
-0.010030102,
-0.0043982263,
-0.016627442,
0.0073884837,
-0.025920035,
0.010968748,
-0.02842756,
0.030036667,
-0.014870833,
-0.014401509,
-0.013617069,
0.031967595,
0.009647938,
-0.01767336,
-0.008776339,
0.005025108,
-0.015903343,
0.0050217556,
-0.004951357,
-0.011766597,
-0.009949646,
-0.003563502,
0.015688796,
-0.006339212,
0.014897651,
0.017767226,
0.0030019907,
-0.008555086,
0.02931257,
0.0072610965,
-0.025584804,
-0.018343823,
-0.018625416,
-0.00524636,
0.0241232,
0.019202013,
0.025531167,
0.008125992,
-0.00411328,
0.050418694,
-0.016198346,
0.018410869,
-0.018625416,
0.015393793,
-0.004193736,
-0.0042708386,
0.013482978,
0.022312954,
0.055192377,
0.021575445,
0.0041065756,
-0.0028243184,
0.016439712,
-0.007944967,
-0.011887279,
0.0079315575,
0.011458185,
-0.029124841,
-0.0057894336,
0.006614101,
-0.0032450329,
-0.01977861,
0.01370423,
-0.017981773,
0.0057089785,
0.018679053,
0.0011548697,
0.010586585,
0.008079059,
0.015112199,
-0.01924224,
-0.032718513,
0.017954955,
0.011250341,
-0.008018717,
-0.016265392,
-0.016265392,
0.0074488255,
-0.0139590055,
0.014133325,
0.007703601,
0.027462097,
0.031645775,
0.024579113,
-0.011471594,
-0.02358683,
0.035105355,
-0.0322626,
-0.008689179,
-0.0015856411,
-0.011632504,
-0.021776585,
-0.018370641,
-0.0155278845,
0.045752283,
0.002613123,
0.013684116,
-0.005665398,
-0.006614101,
-0.015353565,
0.0041702697,
0.006647624,
-0.020435661,
0.00249244,
-0.010680449,
0.022594547,
-0.01066704,
0.0065235887,
0.009607711,
-0.00789133,
-0.022098405,
-0.021401126,
-0.00935964,
-0.0049714707,
0.039262217,
0.016091073,
-0.014763558,
0.01265831,
0.00026147993,
0.012202396,
-0.01258456,
-0.03950358,
0.0073415516,
-0.031323954,
0.00295003,
-0.001979537,
0.019202013,
0.02201795,
0.005310054,
0.023533193,
0.021575445,
-0.027703462,
-0.0044552158,
0.022567729,
0.015152426,
0.015139017,
-0.0023147678,
0.037331287,
0.015621749,
0.0018102456,
0.017834272,
0.013771276,
0.012457171,
-0.026858682,
0.007422007,
0.009379754,
-0.0196177,
0.0061917105,
-0.008722702,
-0.028668927,
0.022929778,
0.00498488,
0.0206368,
0.0020884871,
0.024874115,
0.0081930375,
0.013891959,
0.0013090757,
0.017378358,
-0.010660335,
0.00007296505,
0.0061347215,
-0.024981389,
-0.025611622,
0.0038953803,
-0.005651989,
-0.017043127,
-0.018075638,
-0.008970773,
-0.0011314035,
-0.014602648,
-0.003486399,
-0.011035793,
-0.020945212,
-0.013771276,
-0.01593016,
0.0024773546,
-0.0025092016,
-0.009466914,
0.0046060695,
-0.009668052,
-0.014307645,
-0.004042882,
-0.0051994277,
0.019389741,
-0.02966121,
-0.0032450329,
0.019228831,
0.014629466,
0.0014951287,
0.010539652,
-0.013328771,
0.02756937,
0.01101568,
-0.011699551,
-0.01386514,
0.010660335,
-0.029205296,
-0.013402523,
0.001813598,
-0.009071342,
-0.017257676,
-0.012202396,
0.003814925,
0.011444775,
-0.00017086288,
0.017217448,
0.012188987,
-0.009714984,
0.036124457,
0.029393025,
0.046020467,
-0.0067381365,
-0.023855014,
-0.011706255,
-0.051813252,
0.0039154943,
-0.01854496,
-0.006101198,
-0.01066704,
-0.019657927,
0.005792786,
-0.026255267,
-0.042212244,
0.012859449,
-0.033201244,
-0.010888292,
0.0069459793,
0.029527117,
0.02842756,
-0.0024723262,
0.0024186892,
0.009433391,
-0.007971785,
-0.014562421,
-0.015326746,
0.012765584,
0.0054609077,
-0.024257291,
0.02254091,
0.014495374,
-0.030653492,
0.015326746,
-0.011203409,
-0.021629082,
0.053127356,
0.011780006,
-0.043097254,
-0.010009988,
-0.0049915845,
-0.008608724,
0.0020784303,
0.027260957,
-0.005879946,
-0.020261342,
-0.00050410314,
0.0069996165,
0.014951288,
-0.012933199,
-0.03118986,
0.004384817,
0.03186032,
-0.0066744424,
0.0051994277,
-0.020140659,
-0.008883613,
-0.01180012,
-0.004458568,
-0.024766842,
0.0026600554,
0.0031830152,
0.0022493978,
0.020730665,
0.035507634,
0.037572652,
-0.0039154943,
-0.012101827,
0.044009082,
0.02443161,
0.006775012,
0.011122953,
0.008125992,
-0.021427944,
0.00954737,
0.032396693,
0.004099871,
-0.0014448442,
-0.035427175,
0.004042882,
0.0042473725,
-0.002634913,
-0.02720732,
0.013985824,
-0.03607082,
-0.022728639,
-0.010137375,
-0.018504733,
-0.015326746,
-0.057820585,
0.012799107,
0.020247933,
-0.012665015,
0.017767226,
0.002589657,
0.013221498,
-0.0014515488,
0.02464616,
0.0036137865,
0.00822656,
-0.0073750746,
-0.009138388,
0.012577855,
0.0077907606,
0.039584037,
-0.006446486,
0.008622133,
0.019657927,
-0.000031873104,
0.014361282,
0.0065001226,
-0.0060944934,
-0.018692462,
0.0004689039,
-0.018182911,
0.0120146675,
-0.005926878,
0.0008942278,
-0.052376438,
-0.010988861,
-0.0030690369,
0.008642247,
0.023694104,
-0.023010233,
-0.0171504,
0.031243498,
0.0029751721,
0.033067152,
-0.01630562,
0.019912701,
0.04612774,
-0.0047803894,
-0.038269933,
-0.01873269,
0.0019359571,
0.0024522124,
0.03725083,
0.032396693,
-0.015889933,
-0.0130807,
0.007576213,
0.012229214,
0.013395818,
-0.04355317,
0.026322313,
-0.0075158714,
-0.006557112,
-0.004820617,
0.011303978,
-0.009373049,
0.03277215,
-0.043124072,
0.02238,
-0.03454217,
-0.017726997,
-0.046503197,
-0.00796508,
-0.0039188466,
0.01735154,
0.005608409,
-0.016573803,
0.0006876419,
-0.025879808,
-0.0020750777,
-0.009433391,
0.010418969,
0.021468172,
-0.010962043,
-0.011411252,
-0.002480707,
-0.019215422,
-0.0033975628,
0.0022242556,
0.007703601,
0.040951777,
0.0009478647,
-0.013228202,
0.004029473,
0.0034729897,
0.011632504,
0.019054512,
0.009017705,
-0.023546603,
-0.01975179,
-0.012289557,
0.021427944,
0.02343933,
0.0051323813,
0.018893601,
-0.016935853,
0.0016518491,
-0.04009359,
-0.03295988,
0.0039087897,
-0.05916151,
-0.02915166,
-0.002163914,
0.01421378,
0.024136608,
0.025879808,
0.00058413943,
-0.00796508,
0.016064255,
-0.027649825,
0.012852744,
-0.0015051857,
0.01370423,
-0.008508154,
-0.006114607,
-0.010640222,
-0.025182528,
0.013516501,
-0.017794045,
-0.010834655,
0.0024773546,
-0.027140275,
-0.002785767,
0.021240216,
-0.03242351,
0.009265776,
-0.0011942593,
0.012939904,
0.0069996165,
-0.016104482,
0.02620163,
-0.00045130428,
0.0057190354,
0.010050216,
-0.00096546434,
-0.01457583,
0.012101827,
0.0024103085,
-0.020784302,
-0.015460839,
-0.022071587,
-0.01284604,
0.014093097,
-0.003781402,
-0.008950659,
0.011793415,
-0.0061783013,
-0.012765584,
0.011746483,
0.002435451,
-0.0046295356,
-0.006426372,
0.010123966,
-0.002963439,
0.017431995,
-0.023023643,
-0.010760904,
0.014683103,
-0.0133220665,
-0.033898525,
-0.0023901947,
-0.014455146,
0.040817685,
0.0059067644,
-0.01804882,
-0.024525477,
-0.013375703,
-0.04146133,
-0.0075158714,
-0.014709922,
0.020502707,
0.014535602,
0.02444502,
-0.013985824,
0.0043579987,
-0.011820233,
0.01924224,
-0.01682858,
-0.015621749,
0.027596189,
-0.014093097,
0.00927248,
0.0068286485,
-0.03191396,
0.004187031,
0.050713696,
0.0017968364,
-0.014093097,
0.034783535,
-0.0055614766,
-0.006493418,
0.0009394839,
0.01559493,
0.002417013,
0.012611378,
0.023868423,
-0.013315362,
-0.023117507,
0.021816812,
0.0061079026,
-0.016721306,
0.0071739363,
-0.018223139,
0.010660335,
0.004220554,
-0.011035793,
-0.035078537,
0.037948113,
-0.021897268,
0.016855398,
0.019014284,
0.013999233,
0.011223523,
0.0015613368,
-0.0034998083,
-0.0012428677,
-0.018652234,
-0.00876293,
-0.012544332,
0.036473095,
-0.013027064,
0.006241995,
-0.013905368,
0.013563433,
-0.013771276,
0.005226246,
0.008058946,
-0.019429969,
-0.03102895,
-0.005048574,
0.040495865,
0.0039423127,
0.012095123,
-0.00009035514,
-0.009520551,
-0.0049714707,
0.013771276,
0.0051256767,
-0.013523205,
0.005400566,
-0.0027589484,
-0.03432762,
-0.0073415516,
0.0014197018,
-0.018625416,
-0.01665426,
0.008669065,
0.18429641,
-0.0051625525,
0.012370012,
0.013972415,
-0.011404547,
-0.0013593604,
0.00025519435,
-0.009782031,
-0.0011741454,
0.0018722633,
0.008072355,
0.008876909,
-0.01749904,
-0.000074693584,
0.007287915,
-0.00038991516,
-0.029178478,
-0.025102073,
-0.037519015,
-0.0036975944,
0.0049580615,
0.023787968,
0.0017214095,
-0.013362294,
0.037706744,
-0.022500683,
-0.019483607,
0.001693753,
-0.0025527815,
-0.0014088069,
-0.011324092,
-0.004468625,
0.0042037927,
0.010506129,
-0.0033271643,
-0.0043579987,
-0.0015822888,
-0.0021823517,
-0.0048072077,
0.004240668,
-0.020583164,
0.03558809,
-0.01873269,
-0.009145092,
-0.004773685,
0.0037746974,
0.0017834272,
-0.022138633,
-0.017834272,
0.009661348,
-0.026764818,
-0.0017851033,
0.017096763,
0.018880192,
-0.008984182,
-0.004264134,
0.033040334,
0.0017532564,
-0.0038752665,
0.014951288,
-0.024056153,
0.012986836,
-0.030224398,
0.03349625,
-0.016104482,
0.035749,
-0.020489298,
0.010030102,
0.021883858,
-0.035400357,
0.00823997,
-0.027019592,
-0.015742432,
-0.0014833957,
-0.021106122,
-0.006208472,
0.018464506,
0.05015051,
0.03558809,
0.020717256,
0.0056218184,
-0.0017582849,
-0.0315385,
0.0117531875,
-0.006825296,
-0.026241858,
0.024337746,
-0.0010341866,
-0.010941929,
0.026496632,
0.016506758,
-0.013630479,
-0.017995182,
0.002613123,
0.018330414,
0.0032316237,
-0.028561654,
-0.016895626,
-0.003804868,
-0.022245906,
-0.021924086,
0.07069344,
-0.004763628,
0.009151797,
-0.010177603,
-0.009104865,
0.0037143559,
0.0012772288,
0.014455146,
-0.031136224,
0.013838322,
-0.024713205,
0.0037646403,
0.0011246989,
0.015353565,
0.012879563,
-0.0050418694,
-0.02343933,
0.0036942419,
-0.007985194,
0.026121173,
-0.0268855,
-0.018437687,
0.0251423,
-0.011411252,
0.006272166,
-0.015112199,
0.0061045503,
0.016640851,
-0.042024516,
0.026322313,
0.0056318752,
-0.00066669,
-0.0052765305,
0.016600622,
-0.007797465,
0.013187975,
-0.0144819645,
-0.0105932895,
0.0042239064,
0.009346231,
0.0019845655,
0.0028159376,
0.0028461083,
-0.009694871,
-0.013134338,
0.029258933,
0.010573176,
-0.016117891,
0.00909816,
-0.0197652,
-0.027998466,
0.0043010097,
-0.010606699,
-0.0022795685,
-0.0143881,
-0.017418586,
-0.009647938,
-0.0010886616,
0.0058196043,
-0.042024516,
0.011243637,
0.021146351,
0.0022125223,
-0.0033187836,
0.011183295,
-0.16938536,
0.015916752,
0.0019711563,
-0.030841222,
0.025946854,
0.029741665,
0.022983415,
-0.0027271016,
0.017847681,
0.014066279,
0.015648568,
-0.00033732585,
-0.037679926,
-0.024136608,
-0.0007366694,
-0.013234907,
-0.034086253,
0.00524636,
0.041541785,
-0.009748508,
0.017928137,
-0.03590991,
0.01560834,
-0.010734086,
0.020328388,
-0.015742432,
-0.0021018963,
-0.0120146675,
0.008850089,
0.006667738,
0.0043881694,
0.0007597165,
0.028883474,
-0.037492197,
0.013201384,
-0.0066174534,
0.022406818,
0.008333835,
-0.0105932895,
0.004274191,
0.037170377,
0.028025284,
0.0063660303,
-0.022862732,
-0.010009988,
0.017820863,
0.029553935,
-0.022661593,
0.026952546,
0.015474248,
0.026295494,
-0.009902714,
0.05513874,
0.0031779867,
0.0050116987,
-0.00667109,
-0.014589239,
0.020019976,
-0.0092054345,
0.010472606,
-0.009037819,
-0.003519922,
0.02826665,
0.007254392,
0.0030371898,
-0.02893711,
0.00057408254,
-0.0043579987,
-0.009942941,
0.02306387,
-0.023653876,
0.01066704,
-0.0107743135,
-0.019202013,
0.014414919,
0.0023231485,
-0.022956597,
0.014830605,
0.017700179,
-0.0028276707,
-0.0031126167,
0.011914098,
-0.030009849,
-0.018330414,
-0.01941656,
-0.0012671719,
-0.004066348,
0.0075359857,
0.00051080773,
-0.008018717,
0.0073616654,
-0.029956212,
0.020073613,
-0.020931803,
0.011076021,
0.020019976,
0.01005692,
-0.003082446,
-0.019282468,
-0.011806824,
0.010539652,
-0.024069563,
-0.01180012,
-0.0034729897,
0.029285751,
-0.0025930093,
-0.011793415,
0.003159549,
0.05170598,
0.008977477,
-0.00693257,
0.013630479,
0.028186195,
0.04736139,
-0.017807454,
0.03746538,
-0.01171296,
-0.006436429,
0.018826554,
-0.029205296,
0.059429694,
0.011042498,
-0.0074957577,
0.01422719,
0.0056687505,
-0.0093194125,
-0.12551036,
-0.02358683,
0.018142683,
-0.01230967,
-0.01543402,
0.03521263,
0.0029466776,
0.010425674,
-0.012155464,
0.018330414,
-0.02982212,
-0.0066308626,
-0.007703601,
-0.0096144155,
-0.0040361774,
0.023452738,
-0.008353949,
-0.015353565,
-0.011726369,
0.015018334,
-0.001169955,
-0.0048474353,
-0.0013325419,
-0.006600692,
0.010553061,
-0.024525477,
-0.010935225,
0.0041535078,
0.010043511,
0.03521263,
0.0107542,
-0.014991515,
0.022460455,
-0.017767226,
-0.013201384,
-0.004146803,
-0.022004541,
-0.0018052171,
0.02742187,
0.004361351,
-0.0002591752,
0.0017281141,
-0.013690821,
0.018625416,
0.01595698,
-0.022205679,
-0.0016635822,
-0.00902441,
-0.02236659,
-0.014870833,
-0.025303211,
0.0050686877,
-0.05484374,
-0.017820863,
0.006128017,
-0.027515734,
0.007354961,
0.016560394,
-0.009466914,
-0.014830605,
0.004699934,
-0.011572163,
-0.018357232,
0.0152597,
0.013027064,
-0.02515571,
0.007596327,
-0.002251074,
0.024766842,
-0.051625524,
0.02826665,
-0.008092469,
-0.035534453,
-0.0098423725,
-0.022675002,
-0.0047099907,
-0.017485632,
-0.020261342,
0.0081595145,
0.013348885,
-0.010050216,
-0.012524217,
0.0076968963,
-0.0021789994,
0.019845655,
-0.0067850687,
0.009339526,
-0.005212837,
-0.006255404,
-0.011853756,
-0.010707268,
0.049399592,
-0.008025422,
-0.002755596,
0.0105128335,
0.021897268,
-0.028481198,
0.002656703,
-0.0061380737,
0.013945596,
-0.05133052,
0.0072342777,
-0.067528866,
0.008662361,
-0.006091141,
-0.013905368,
0.018679053,
-0.010734086,
-0.013301953,
0.01975179,
0.008548382,
0.018370641,
-0.01697608,
0.010090443,
-0.021293852,
0.0150049245,
-0.027649825,
0.005222894,
0.025303211,
-0.023184553,
-0.0042239064,
0.017794045,
-0.0019761848,
-0.008923841,
-0.0039624264,
0.021883858,
0.00980885,
-0.010439083,
-0.0042574294,
0.015353565,
-0.00047644658,
-0.0024773546,
0.012879563,
-0.02842756,
-0.013027064,
0.010874883,
0.0030455706,
-0.014066279,
0.009527256,
0.020851348,
0.013469568,
0.047093205,
-0.02705982,
-0.05336872,
-0.013489682,
0.007857807,
0.024874115,
-0.0032265952,
-0.05240326,
0.0048072077,
0.0048809587,
-0.00137696,
0.040871322,
0.015206063,
-0.0261614,
-0.013985824,
-0.024860706,
-0.0016216784,
0.0034277337,
-0.02396229,
-0.0046731154,
0.0015722319,
0.022527501,
0.017472222,
0.011049203,
0.0068923426,
-0.01014408,
-0.003660719,
-0.01768677,
-0.006919161,
0.00007657926,
-0.01213535,
-0.031618956,
0.00437476,
-0.004183679,
0.024900934,
0.0039389604,
0.007750533,
-0.02566526,
0.008266788,
-0.006516884,
-0.0085752,
-0.00048021795,
-0.007301324,
-0.009936237,
0.0038082204,
0.022152042,
0.001016587,
0.0068554673,
0.008085764,
0.0017901318,
0.02307728,
0.006483361,
0.02668436,
-0.003213186,
0.016895626,
-0.004445159,
-0.0050083464,
-0.013643888,
-0.013824913,
0.013932186,
0.038430844,
-0.016493348,
0.00066962326,
-0.014508784,
-0.02046248,
-0.0064029056,
0.030009849,
-0.026952546,
-0.026027309,
0.0032500613,
-0.009292594,
0.02166931,
-0.007844398,
0.015970388,
0.0011691169,
0.0040093586,
-0.010586585,
-0.026979364,
-0.003597025,
-0.006295632,
0.017606314,
-0.0034562282,
0.02689891,
0.017914727,
0.0032651466,
0.008099173,
0.014401509,
0.013348885,
-0.021052485,
0.015541294,
-0.010036807,
-0.013053882,
-0.010874883,
-0.03137759,
-0.017713588,
-0.019470198,
-0.014937879,
-0.0066308626,
0.023640467,
-0.00030757414,
0.08394176,
0.016439712,
-0.016895626,
-0.010539652,
-0.026670951,
0.0034696374,
0.015031743,
-0.008246674,
-0.00693257,
-0.013020359,
0.033683978,
-0.015219472,
0.021293852,
-0.024351155,
-0.04473318,
0.009681461,
-0.0012370012,
-0.010244649,
0.0071202996,
-0.009118274,
0.022299545,
-0.012698538,
0.0025963616,
0.0071739363,
-0.01594357,
0.015045152,
0.021897268,
-0.005695569,
-0.02443161,
-0.021307262,
0.015581521,
-0.017136991,
-0.052054618,
-0.003761288,
0.009768622,
-0.0066744424,
-0.024418201,
0.0066409195,
0.033925343,
0.0130941095,
0.011257046,
-0.023278417,
-0.006154835,
-0.023023643,
0.010660335,
-0.012765584,
-0.013335476,
-0.009654643,
-0.012349898
] |
Subunits of the SWI/SNF chromatin remodeling complex are mutated in a significant proportion of human cancers. Malignant rhabdoid tumors (MRTs) are lethal pediatric cancers characterized by a deficiency in the SWI/SNF subunit SMARCB1. Here, we employ an integrated molecular profiling and chemical biology approach to demonstrate that the receptor tyrosine kinases (RTKs) PDGFRα and FGFR1 are coactivated in MRT cells and that dual blockade of these receptors has synergistic efficacy. Inhibitor combinations targeting both receptors and the dual inhibitor ponatinib suppress the AKT
|
[
-0.011265301,
-0.0069782655,
-0.022395365,
-0.027372112,
-0.021151178,
0.026560685,
-0.008722832,
-0.0012957463,
-0.017918997,
0.0019085421,
0.022760507,
0.0061803632,
0.007086456,
0.012421583,
-0.004429035,
-0.011637204,
0.0261144,
-0.013023391,
-0.015430622,
-0.007850549,
-0.0064136484,
0.033971712,
-0.0040030363,
-0.025843926,
0.010075209,
0.03113172,
0.011015112,
-0.04254578,
-0.011447872,
-0.014159388,
0.0065488857,
-0.007032361,
0.008161595,
-0.01176568,
-0.014943766,
0.00688698,
0.013740151,
-0.002266922,
0.0035466088,
-0.00731636,
0.013111295,
0.008560547,
0.0025999448,
0.002231422,
-0.017634997,
-0.019866418,
0.02101594,
-0.01983937,
-0.014091769,
0.01764852,
0.00088749744,
-0.0038644176,
-0.02374774,
-0.020150417,
-0.02216546,
-0.016931761,
0.014267578,
0.046657007,
0.010893397,
-0.009946734,
-0.0038001796,
-0.00408756,
-0.038786173,
0.019595943,
0.0006280101,
0.006366315,
0.014051198,
0.0013439247,
-0.014186435,
0.0005688436,
0.04489892,
0.02359898,
-0.009270545,
-0.012705582,
0.015647003,
-0.023950597,
-0.033187333,
0.007816739,
-0.002417374,
-0.0040909406,
0.014145864,
-0.01875747,
-0.0049835094,
0.025343547,
0.012326917,
-0.0011630442,
-0.000498689,
-0.0016296144,
0.016485477,
0.021097083,
0.019190231,
0.038434558,
-0.0015738287,
-0.0011038778,
-0.009892638,
0.011900919,
0.0019457325,
0.001448734,
0.0012830677,
-0.025735736,
-0.016296143,
0.008357691,
-0.0027520873,
-0.011170634,
-0.019244326,
-0.0003416865,
0.0022939695,
-0.0050376044,
0.010420065,
-0.008844546,
-0.025925068,
0.029454771,
-0.010933968,
-0.024505071,
0.038001794,
-0.009689782,
0.029400676,
-0.0073366454,
0.0093516875,
-0.0078032156,
0.018852137,
0.02794011,
0.0010717588,
-0.029671153,
0.03567571,
-0.0122863455,
-0.019879943,
-0.007722073,
-0.027250398,
-0.00047798076,
0.008614642,
0.0133412,
-0.0004995343,
-0.01176568,
-0.012597392,
0.0018273995,
-0.010873112,
-0.02765611,
-0.046467677,
-0.025532879,
-0.0011605086,
0.02216546,
-0.027777825,
-0.024234597,
-0.013970055,
-0.003762989,
0.01108273,
-0.001682019,
0.013510247,
-0.023869455,
0.0027588492,
-0.023071552,
0.006504934,
-0.008066929,
-0.014538053,
0.018392328,
-0.009967019,
0.042302355,
-0.025600499,
-0.0024562548,
0.00080424175,
0.005253985,
0.016972331,
0.030401437,
0.028886775,
0.029319534,
0.002026875,
0.0033792523,
-0.00071126583,
0.0031966812,
0.02869744,
0.020474989,
-0.03554047,
0.0015789003,
-0.01893328,
0.0020032085,
-0.009595116,
0.018514043,
-0.023396123,
-0.004658939,
-0.009581591,
0.004205893,
0.025708688,
0.0017208998,
-0.0068125995,
-0.017459188,
0.029427724,
-0.013983578,
-0.016296143,
-0.008398262,
0.0053249844,
0.0010354137,
0.0030310152,
-0.021827366,
-0.63009953,
-0.009371973,
0.021813842,
-0.010528255,
0.01366577,
0.038732078,
0.023517838,
-0.0010624612,
-0.008371214,
0.011434348,
-0.016715381,
0.027426207,
0.013219486,
-0.025221832,
-0.019785276,
-0.025803354,
-0.017662045,
-0.01380777,
0.033160284,
0.015119576,
-0.03324143,
0.008202167,
-0.009054164,
0.005707031,
0.004821224,
0.0031155387,
0.01645843,
-0.02166508,
0.007120265,
0.023355551,
-0.04765777,
0.029941628,
-0.002378493,
0.013564342,
0.048901953,
0.006247982,
-0.0026050163,
0.042058926,
0.040436074,
0.023828885,
0.002241565,
0.012692058,
0.02040737,
0.002596564,
-0.020447941,
0.014781482,
-0.002158732,
0.009365211,
-0.0009796282,
-0.0122322505,
0.015876906,
-0.0015053647,
-0.043952253,
-0.004009798,
0.017689092,
0.002446112,
0.014781482,
-0.0058084596,
-0.017837854,
0.013970055,
-0.014538053,
0.02772373,
-0.0016777928,
-0.0020522322,
0.009818258,
-0.00056546263,
0.0068666944,
0.016999379,
-0.009121783,
0.007607121,
0.02249003,
0.023774788,
-0.0028636584,
0.017770234,
0.0151331,
0.029562963,
-0.0016389119,
0.01251625,
-0.016079763,
0.0018409232,
0.018987374,
-0.0060282205,
-0.026520114,
0.010528255,
0.023855932,
-0.0048719384,
-0.03554047,
0.032375906,
0.018243566,
-0.0055515077,
-0.014511006,
-0.015038433,
-0.020204512,
-0.030347342,
-0.009926448,
0.0118806325,
0.012820534,
0.033187333,
-0.007870834,
-0.048388053,
-0.021840889,
-0.003446871,
0.0057340786,
-0.018175948,
0.01710757,
-0.008580833,
-0.039435316,
0.0038644176,
0.017350998,
-0.035486374,
-0.011136825,
-0.011380253,
0.004347892,
-0.0020691368,
-0.013422342,
-0.019366039,
0.022922792,
0.022530602,
-4.1601442e-7,
-0.015268337,
0.010825778,
-0.013361486,
0.012103775,
-0.0073704547,
0.014903195,
0.007302836,
0.0027030637,
-0.0071540745,
0.011637204,
-0.017418617,
0.012455393,
-0.017283378,
0.01914966,
-0.030455532,
0.011035397,
0.009696543,
0.01667481,
-0.0009669496,
0.012989582,
-0.025870973,
-0.020069275,
-0.0032998,
0.011393777,
0.005409508,
0.011163873,
-0.015958048,
-0.025614021,
0.005402746,
0.008161595,
-0.014619196,
0.00717436,
-0.01047416,
-0.015471194,
0.008229215,
0.021070035,
-0.015227766,
-0.01083254,
-0.03243,
0.01424053,
-0.018108329,
0.01793252,
-0.00595384,
-0.020474989,
-0.016296143,
-0.0049497,
-0.005585317,
-0.004726558,
0.0032693716,
0.0114749195,
-0.032943904,
-0.0055650314,
-0.013185676,
-0.02557345,
0.0052776514,
0.0009584972,
0.02353136,
-0.011961775,
-0.009000069,
-0.015200718,
-0.006417029,
0.00064533745,
-0.01858166,
-0.019447181,
0.019095564,
0.025100118,
0.029968675,
0.03829932,
-0.012495964,
-0.009730353,
0.019338991,
-0.019284897,
0.018716898,
0.0017851377,
0.022178983,
0.008073691,
-0.025262404,
0.013760436,
0.016133858,
-0.009852067,
0.043708827,
-0.0052708895,
-0.012103775,
0.02270641,
0.0030242533,
0.0103118755,
-0.0036683227,
0.0026303735,
-0.00918264,
0.020204512,
0.0044594635,
-0.006836266,
0.015903953,
-0.007032361,
-0.0006930932,
-0.01639081,
0.014213483,
-0.021381082,
0.014091769,
-0.009365211,
-0.015430622,
-0.0010092114,
-0.003421514,
0.0075056925,
-0.01858166,
0.018770993,
0.011434348,
-0.003948941,
0.025100118,
0.014213483,
0.010913683,
-0.015985098,
0.020353274,
0.02535707,
0.008790451,
-0.014064722,
0.008641689,
-0.0036784655,
-0.006542124,
0.04005741,
0.0062682675,
-0.00075099187,
0.00163215,
-0.015173671,
-0.002525564,
0.010737874,
-0.012861106,
0.01660719,
0.009493687,
-0.002528945,
0.022422412,
-0.03291686,
0.019744705,
-0.01115711,
0.023369076,
0.009912924,
-0.014362244,
0.02453212,
0.010731112,
0.040219694,
0.018459946,
-0.00073746813,
0.0045744153,
0.017743187,
-0.00932464,
-0.021313462,
0.033620093,
0.009311116,
0.0016989236,
0.011995585,
-0.0010700683,
-0.010947492,
0.0025948735,
0.000724367,
-0.03935417,
0.007377217,
-0.0005050283,
0.011819775,
0.011785966,
0.012610916,
0.017526807,
0.009013593,
-0.03540523,
0.040895883,
0.008046644,
-0.01589043,
-0.027345063,
-0.031834956,
0.011461396,
-0.012198441,
0.007864073,
0.02331498,
-0.00032182346,
-0.0079114055,
0.017053476,
-0.015687574,
-0.022517078,
0.012306632,
-0.014105293,
0.004723177,
-0.007309598,
0.019000897,
-0.0029008489,
0.0022939695,
-0.0075056925,
0.030969435,
0.0030986338,
-0.011927966,
-0.015538813,
-0.022138413,
-0.01990699,
-0.00033598117,
-0.02134051,
0.006082316,
-0.021705652,
-0.019501276,
-0.003712275,
0.014321673,
-0.0071405508,
0.0033099428,
-0.0012796868,
-0.03091534,
-0.02765611,
0.0025238737,
-0.0022263508,
0.030212104,
0.05325661,
-0.011691299,
-0.00182909,
-0.009439592,
0.00261854,
-0.01714814,
-0.024288692,
0.020569654,
-0.036000278,
0.01908204,
0.008844546,
-0.010981302,
0.017918997,
0.006711171,
0.028913822,
0.002916063,
-0.009534258,
-0.024369834,
0.008743118,
0.008533499,
-0.021502795,
0.031916097,
0.041950736,
0.012671773,
0.005531222,
0.004128131,
0.021286415,
0.020474989,
-0.03981398,
0.00084481307,
-0.0042802733,
-0.003935417,
0.012523011,
-0.005196509,
-0.045358725,
0.01868985,
0.00860788,
-0.005172842,
0.0032845857,
0.018405851,
-0.008979783,
0.019122612,
0.00778293,
0.017039951,
-0.0020319466,
-0.0028416822,
-0.009703306,
-0.014402816,
-0.013246533,
0.011921204,
-0.010731112,
0.0014123888,
-0.010737874,
0.0010590802,
-0.0056461743,
-0.00932464,
-0.021191748,
-0.012800249,
-0.03002277,
-0.010494446,
-0.0026810875,
0.0053520324,
-0.016796524,
-0.012239012,
0.005649555,
0.0042498447,
-0.0058152215,
-0.0126379635,
-0.0022804458,
0.010974539,
-0.019988133,
-0.029725248,
0.0027639207,
0.01714814,
0.010906921,
0.007654454,
0.0031510384,
-0.005331747,
0.038596842,
-0.010562065,
0.00046107607,
-0.0071540745,
-0.033836473,
-0.021800319,
-0.014551577,
0.0055751745,
-0.019920515,
-0.029103154,
0.020691369,
0.018676328,
0.002385255,
0.03429628,
-0.01958242,
-0.008912165,
0.018595185,
0.031104673,
0.018527566,
-0.0069782655,
0.013638723,
0.005828745,
-0.015444146,
-0.012225488,
-0.010075209,
-0.01075816,
-0.01104892,
0.0028095634,
0.0039387983,
-0.022300698,
-0.006890361,
-0.013009868,
-0.01578224,
-0.021678604,
-0.0020065894,
0.033565998,
0.019136135,
0.0004340285,
0.0032034433,
-0.00946664,
0.0024241358,
-0.0027588492,
-0.0072690267,
0.013861865,
-0.012320155,
-0.018108329,
0.01452453,
-0.0012239013,
-0.02722335,
-0.017242808,
-0.014511006,
0.007201408,
0.05103871,
0.01897385,
-0.026655352,
-0.011501967,
-0.0004995343,
-0.03651418,
-0.005652936,
-0.0052708895,
-0.012861106,
-0.02140813,
0.014592148,
0.01635024,
-0.011001587,
-0.013544057,
-0.03321438,
-0.0019102326,
0.024991928,
0.0022973504,
0.0065252194,
-0.019636516,
-0.004598082,
-0.02001518,
-0.02123232,
-0.02359898,
-0.0385157,
-0.01294901,
0.00512889,
0.046765197,
0.031158768,
0.040084455,
0.00308511,
0.012692058,
0.030726006,
0.02399117,
-0.01330739,
0.0040503694,
0.024829643,
-0.025221832,
0.027750777,
0.008134548,
0.008803975,
0.0121578695,
-0.0033505142,
0.026263162,
0.012597392,
-0.0068734563,
-0.029454771,
0.012225488,
-0.039786935,
-0.020272132,
0.0096830195,
-0.017702615,
-0.0041585593,
-0.03938122,
0.006846409,
0.03102353,
0.016769476,
-0.0014647933,
-0.016242048,
0.013584628,
-0.020447941,
0.015349479,
-0.028859727,
0.015051956,
-0.011792728,
-0.016120335,
0.0034857518,
-0.0056901267,
0.0051998897,
0.015268337,
0.005994411,
0.017405093,
-0.010345684,
0.0025559927,
0.002033637,
-0.015308908,
-0.025925068,
-0.012536535,
-0.03529704,
-0.016120335,
-0.012137584,
-0.0130572,
-0.053824607,
0.003959084,
0.010460637,
-0.030428484,
0.01204968,
0.01958242,
-0.002557683,
0.020745464,
-0.011407301,
0.027629063,
-0.020569654,
0.013212724,
0.024180502,
0.0005942007,
-0.005203271,
-0.010893397,
-0.004418892,
0.015390051,
0.03967874,
0.034242187,
-0.00828331,
-0.0036243706,
-0.0022855173,
0.0010523184,
-0.009595116,
-0.026939351,
0.02650659,
-0.003073277,
0.011305872,
-0.014308149,
0.0021823985,
-0.033620093,
0.024383359,
-0.0004855879,
0.011792728,
-0.006782171,
-0.016620714,
-0.03554047,
0.024410406,
-0.015755193,
0.01610681,
0.009311116,
-0.02101594,
-0.009628925,
-0.005784793,
-0.00015224807,
0.0018392327,
-0.017391568,
0.03705513,
0.013070724,
-0.02353136,
0.01506548,
0.005771269,
-0.004557511,
-0.0017310426,
-0.001029497,
0.04741434,
0.0041078455,
0.0054636034,
-0.0054974128,
0.0018882565,
0.0064474577,
0.036811702,
0.0025120403,
-0.015011385,
-0.041815497,
-0.008357691,
0.027683157,
0.01047416,
-0.02227365,
0.011366729,
-0.02012337,
-0.0027875872,
-0.006369696,
-0.031104673,
0.014159388,
-0.06567143,
-0.028967917,
-0.009331401,
0.018960327,
0.02105651,
0.019311944,
-0.010933968,
-0.0025272546,
0.042843305,
-0.008810736,
-0.0011309253,
0.0041382737,
0.010372732,
-0.010683779,
0.009216449,
-0.0031544196,
-0.04224826,
0.010068447,
-0.010575589,
-0.020150417,
-0.0058659357,
-0.0044662254,
0.0005692662,
0.0144839585,
-0.020583179,
0.027696682,
-0.01452453,
0.0060417447,
-0.010988063,
-0.007722073,
0.0016558167,
-0.029617058,
0.009121783,
0.011718347,
-0.01725633,
-0.013185676,
0.005784793,
-0.000053513984,
0.009770924,
0.012103775,
0.0035466088,
-0.012908439,
0.0070594084,
-0.021935556,
0.006846409,
-0.0028433728,
-0.0042092735,
-0.017269855,
0.007735597,
-0.008628165,
-0.021719176,
-0.0042735115,
-0.0073298835,
-0.028913822,
0.00595384,
-0.031537432,
-0.0032575382,
-0.011292349,
-0.014943766,
-0.04698158,
-0.005531222,
-0.029968675,
0.032051336,
0.017026426,
-0.009257021,
-0.015958048,
-0.021976126,
-0.040327884,
-0.015971573,
-0.008276547,
0.008006073,
0.0074651213,
0.009750638,
-0.020610226,
0.015214242,
0.004239702,
0.020637274,
0.02012337,
-0.012164632,
0.017094046,
0.011096254,
0.011745395,
0.0049936525,
-0.0407336,
-0.023693645,
0.056475267,
-0.0075462637,
-0.0119550135,
0.015971573,
-0.019879943,
0.012773201,
-0.0035161804,
0.004598082,
0.0016617333,
0.029752295,
0.0146868145,
-0.003715656,
-0.0097574005,
0.020907748,
0.022828124,
-0.007742359,
0.020529084,
0.0007843787,
0.013571104,
0.0031763955,
-0.0016262335,
-0.0047434624,
0.011819775,
0.0056360313,
0.031645622,
0.019176707,
0.028913822,
0.007715311,
0.010886636,
-0.012610916,
-0.004909129,
-0.014876148,
-0.013178915,
-0.012786725,
0.019000897,
-0.009507211,
-0.0081886435,
0.00148846,
0.0041146073,
0.003213586,
-0.014605672,
-0.0060620303,
-0.0070458846,
-0.013719865,
0.010426827,
-0.021259367,
-0.0012399607,
-0.0053520324,
0.004310702,
-0.031970195,
0.0008388964,
-0.004222797,
0.01897385,
-0.016701857,
-0.002894087,
0.012299869,
-0.026736494,
-0.007776168,
-0.0021384463,
-0.00505789,
-0.01886566,
0.022746982,
0.20469579,
-0.003056372,
-0.014402816,
0.020542607,
0.0106432075,
-0.0068024565,
0.02238184,
-0.010393018,
-0.0032102051,
0.0024241358,
0.012935487,
0.029346582,
-0.008486166,
-0.005304699,
0.01380777,
0.013753675,
-0.02926544,
-0.023950597,
-0.029860485,
-0.0051491754,
0.010528255,
0.012151108,
-0.00530808,
-0.009236735,
0.023666598,
-0.0026777065,
-0.028643345,
-0.010900159,
0.018405851,
0.00047248675,
-0.03210543,
0.012665011,
0.003414752,
-0.01000759,
-0.0036277515,
-0.007120265,
-0.021962604,
-0.000047042646,
0.006244601,
0.023274409,
-0.015051956,
0.0005084092,
0.0072690267,
-0.011738633,
-0.008235976,
0.0107175885,
-0.011643967,
-0.0036311324,
0.008837784,
0.0033014906,
-0.04246464,
0.017973091,
0.02739916,
0.019568896,
0.0019677086,
-0.015146623,
0.010325399,
-0.0013642104,
-0.009825019,
0.027318016,
-0.031834956,
-0.0054974128,
-0.018879184,
0.022895744,
-0.017797282,
0.036297802,
-0.029508868,
0.02496488,
0.026831161,
-0.020894226,
-0.0019930657,
-0.02249003,
-0.020393847,
-0.007924929,
-0.0038373698,
-0.013456152,
0.035459325,
0.01897385,
0.043762922,
0.044276826,
-0.00010988064,
0.0003883858,
-0.024410406,
0.021583937,
-0.022138413,
-0.028967917,
0.023058029,
0.00088242604,
0.0063866004,
-0.0036818464,
0.008405023,
-0.0065319813,
-0.0043242257,
0.003411371,
0.022584697,
-0.009480163,
-0.010305113,
0.006998551,
0.0010193542,
-0.017743187,
-0.032754574,
0.0846588,
-0.00005401584,
0.0133412,
-0.011062444,
0.0008579142,
0.02166508,
-0.00012583446,
0.016945284,
-0.017797282,
0.0043309876,
-0.02600621,
0.0020691368,
-0.010548541,
0.009534258,
0.0018798041,
-0.00006022304,
-0.040219694,
0.003715656,
-0.01014959,
0.015958048,
-0.023463743,
-0.003600704,
0.014443387,
-0.028102396,
0.012468916,
-0.024762023,
-0.010954254,
0.010859588,
-0.029860485,
0.01369958,
-0.0031053957,
0.003005658,
0.0016422928,
0.0027301111,
-0.019879943,
0.023125648,
0.0040334645,
0.000054781834,
0.018770993,
0.0022567792,
0.01667481,
0.009108259,
0.017864902,
-0.010622921,
-0.016526047,
0.023044504,
0.021976126,
-0.0046758438,
0.002944801,
-0.007654454,
-0.00077803945,
0.006991789,
-0.026209068,
0.01251625,
-0.033160284,
0.003539847,
-0.03840751,
0.0028163253,
0.0050477474,
-0.028454013,
0.010967778,
0.01714814,
-0.009973781,
-0.012293108,
0.008073691,
-0.17191418,
0.019406611,
0.021529842,
-0.019988133,
0.009006831,
0.027358588,
0.027412683,
-0.008093976,
0.0057915547,
0.0034096807,
0.033755332,
0.00039599292,
-0.028616298,
-0.011096254,
0.006129649,
0.009885876,
-0.0052810325,
0.03345781,
0.015876906,
0.017729662,
0.014619196,
-0.032484096,
0.008215691,
-0.018202996,
-0.013550818,
-0.000692248,
-0.0059267925,
-0.017864902,
-0.028318776,
0.0034130616,
-0.014010626,
0.006322363,
0.025532879,
-0.022138413,
0.02127289,
0.0051694615,
0.004422273,
0.019555373,
0.0053452705,
0.017851377,
0.039029602,
0.019650038,
0.02524888,
-0.005122128,
-0.016904714,
0.025302975,
0.008547023,
-0.0068768375,
0.0098317815,
-0.0032693716,
0.016715381,
-0.0037291797,
0.011758919,
0.016512524,
0.026939351,
0.028454013,
0.0029836819,
-0.008425309,
-0.013489961,
-0.012495964,
-0.023328504,
-0.016187953,
0.04543987,
-0.009635687,
-0.006376458,
-0.032402955,
-0.031212863,
-0.007979024,
-0.038759127,
0.0017648521,
-0.019474229,
0.016931761,
0.015146623,
-0.010244256,
0.009480163,
-0.0012441869,
-0.007600359,
0.0082495,
-0.014227007,
-0.0021080177,
-0.0016499,
-0.0018612089,
-0.016958809,
-0.008202167,
-0.003607466,
0.00022927017,
0.0036176087,
-0.001857828,
-0.0011520562,
-0.009615401,
0.017094046,
-0.017797282,
0.039516456,
-0.00022377614,
0.027858967,
0.00979121,
-0.004415511,
-0.0058693164,
-0.0060316017,
0.0009534258,
0.01599862,
-0.02618202,
-0.010190161,
-0.00057983166,
0.036027323,
-0.0031425862,
-0.0028433728,
0.01793252,
0.033565998,
-0.0071473126,
0.0036446562,
0.0043918444,
-0.003583799,
0.013402057,
-0.0042735115,
0.0050443662,
0.0018324709,
0.003364038,
0.0057273167,
-0.034485616,
0.08390147,
0.0049057477,
0.015363003,
0.018081281,
-0.0005434865,
-0.02711516,
-0.11944194,
-0.027358588,
0.013239771,
-0.00412475,
-0.0313481,
0.0011165563,
0.0007712775,
0.01667481,
-0.0017082213,
0.04049017,
-0.029617058,
-0.035134755,
-0.00720817,
0.0039793695,
0.015444146,
0.002363279,
0.032592285,
-0.035702754,
-0.012198441,
0.032862764,
-0.004188988,
0.0057374598,
0.009939971,
-0.006433934,
-0.00085030706,
0.0013329367,
-0.032754574,
0.01495729,
0.01377396,
0.015538813,
0.0044662254,
-0.014497482,
0.029887533,
-0.00731636,
-0.02468088,
0.004527082,
-0.03278162,
-0.029427724,
0.023761265,
0.004117988,
0.008222452,
0.004851653,
0.01990699,
-0.0017648521,
-0.003076658,
0.008580833,
-0.022043746,
0.017851377,
0.03156448,
-0.0065691713,
-0.011650728,
-0.02359898,
-0.02711516,
0.002023494,
0.007350169,
-0.023734218,
0.00789112,
0.020704893,
-0.0024241358,
-0.00720817,
-0.01736452,
-0.00092215213,
0.009473401,
0.016336715,
0.0014876148,
-0.0058693164,
-0.0026726353,
-0.029238392,
0.02915725,
-0.011833299,
0.0052100327,
0.0023193266,
-0.027804872,
-0.007945215,
-0.024883738,
0.000781843,
-0.033836473,
-0.015876906,
0.0066841235,
-0.023937074,
-0.026236115,
-0.015579384,
0.014511006,
-0.029346582,
0.0263984,
-0.0060789348,
0.002877182,
-0.020745464,
0.00042346306,
-0.01778376,
0.009960257,
0.027318016,
-0.025154212,
0.0027487064,
-0.009480163,
0.017053476,
-0.0050376044,
0.004767129,
0.011610157,
0.03453971,
-0.045169394,
-0.018716898,
-0.06962037,
0.023828885,
0.0095545435,
-0.0019085421,
0.01545767,
0.0004243083,
0.007951977,
-0.0055751745,
0.0054872697,
0.023382599,
-0.0077626444,
0.017526807,
-0.008790451,
0.00087397365,
-0.013733389,
-0.015728146,
0.01635024,
-0.0038677985,
0.010068447,
0.031402197,
-0.011921204,
-0.022395365,
0.012164632,
0.03002277,
0.010785207,
-0.015511765,
-0.021746224,
0.019095564,
-0.007539502,
0.0056157457,
0.018230043,
-0.04519644,
-0.024721453,
-0.005713793,
0.0041484167,
-0.014862624,
0.00089256885,
0.026777066,
0.0029363488,
0.018716898,
-0.018351756,
-0.046765197,
-0.0045710346,
-0.0067956946,
-0.0013219486,
0.0008033965,
-0.02894087,
0.021259367,
0.0036852274,
-0.0045067966,
0.013030153,
0.0072757886,
-0.0035263232,
-0.024762023,
-0.033079144,
-0.00677879,
-0.004604844,
0.005186366,
-0.0083914995,
-0.016052715,
0.0121578695,
0.013537294,
0.015714621,
-0.00044374872,
0.0050883186,
0.0029650866,
-0.023774788,
0.0034198235,
0.007032361,
-0.026249638,
-0.026885256,
0.011853585,
0.0280483,
0.008560547,
-0.0043850825,
-0.009196164,
-0.02733154,
-0.00005546859,
-0.009919685,
0.013023391,
0.0022652317,
0.008357691,
-0.016715381,
0.0047130343,
0.01025778,
-0.007857311,
-0.0062141726,
0.019014422,
0.0009196164,
0.01632319,
-0.0039624646,
0.015647003,
0.013429104,
0.008628165,
0.008148071,
0.030671911,
-0.015430622,
-0.0023260885,
0.011637204,
0.027345063,
-0.01714814,
-0.015471194,
-0.0013642104,
0.0002461749,
0.0054974128,
0.012644726,
-0.02783192,
-0.016945284,
-0.007553026,
-0.00871607,
0.028210586,
0.0139294835,
0.00035436504,
0.008689023,
-0.010136066,
0.006112744,
0.000037586575,
-0.022219555,
0.005368937,
0.019447181,
0.021421652,
0.018135376,
0.019054992,
0.011840061,
0.012414821,
0.0068835993,
0.014700338,
-0.021502795,
0.025127165,
-0.026831161,
0.0118062515,
-0.0003006926,
-0.01914966,
0.0050207,
-0.008979783,
-0.008634928,
-0.014321673,
0.02635783,
-0.026317257,
0.09450411,
0.008026358,
-0.023585455,
-0.017121093,
-0.025451737,
0.028454013,
0.034837235,
-0.0029498725,
-0.021867936,
-0.047441386,
0.00943283,
-0.019406611,
0.016701857,
-0.025411164,
-0.016810047,
0.011535776,
-0.005267509,
0.007478645,
0.0096830195,
-0.022395365,
0.0010489374,
0.0029143726,
-0.0071405508,
0.033403713,
-0.025059547,
-0.00932464,
0.028886775,
0.013496723,
-0.007823502,
-0.02733154,
-0.004932795,
-0.023409646,
-0.031104673,
-0.0071608364,
0.028724488,
-0.011454633,
0.0014064722,
-0.015822811,
0.025194785,
0.024505071,
0.008831022,
-0.020691369,
0.0065725525,
-0.010406542,
0.022544125,
-0.008323881,
0.002158732,
-0.02238184,
-0.0062040295
] |
Very often, the positions of flexible domains within macromolecules as well as within macromolecular complexes cannot be determined by standard structural biology methods. To overcome this problem, we developed a method that uses probabilistic data analysis to combine single-molecule measurements with X-ray crystallography data. The method determines not only the most likely position of a fluorescent dye molecule attached to the domain but also the complete three-dimensional probability distribution depicting the experimental uncertainty. With this approach, single-pair fluorescence resonance energy transfer measurements can now be used as a quantitative tool for investigating the position and dynamics of flexible domains within macromolecular complexes. We applied this
|
[
-0.008195029,
-0.007886541,
-0.01748988,
-0.014606196,
-0.015665783,
0.033772636,
-0.025322773,
0.011990761,
-0.017556943,
-0.007618292,
0.016577832,
0.012359605,
0.019340804,
0.027267583,
-0.014901271,
-0.012111474,
0.030875541,
-0.009730758,
-0.017583769,
-0.020910064,
-0.014230647,
0.012855867,
-0.02471921,
-0.029292868,
-0.0051805726,
0.025242297,
0.019850478,
-0.014458659,
-0.03060729,
-0.005026329,
-0.0029859545,
0.008858946,
-0.02784432,
-0.032458212,
-0.009422271,
0.0029507468,
0.016242519,
0.028622244,
0.008154791,
-0.018321455,
0.016014507,
0.011642037,
-0.003654902,
-0.008127966,
0.017167982,
-0.011796281,
0.018388517,
0.0049458537,
-0.03275329,
0.012198655,
-0.00426517,
0.03339709,
-0.00063793134,
-0.022009889,
-0.020440627,
-0.026529895,
0.003909739,
-0.005998734,
-0.0029105092,
-0.017905667,
-0.011098832,
-0.007323217,
-0.015531658,
-0.0020386977,
0.002762972,
-0.0016857818,
-0.0019565462,
0.023337724,
-0.0024528082,
-0.007879835,
0.03658926,
0.011481088,
-0.00069116213,
0.0037554959,
0.045200076,
0.01049527,
-0.017878843,
0.0084364535,
-0.0031955247,
0.012768686,
0.000006107003,
-0.019877303,
-0.008604109,
0.031277914,
-0.0075109918,
-0.010045951,
-0.01317106,
0.024196124,
-0.011534737,
-0.0032977948,
0.03827923,
0.05077967,
-0.0021510273,
-0.0024058644,
-0.030768242,
-0.01270833,
0.00058176654,
0.034470085,
-0.0011367081,
-0.03669656,
-0.006173096,
0.013305185,
-0.012138299,
-0.015075633,
-0.017878843,
-0.014914683,
0.0028400938,
-0.008812003,
-0.0047044293,
-0.024571672,
-0.024786273,
0.030070791,
0.008081023,
-0.0068940176,
0.010817169,
-0.018656766,
0.028434468,
-0.019796828,
-0.0078932475,
-0.0004727901,
-0.011045181,
0.012674798,
0.0030798418,
-0.01592062,
0.047560673,
-0.0020252853,
-0.020682052,
-0.013580142,
-0.00092797633,
0.002446102,
0.00079468975,
0.011876755,
-0.008315741,
0.017355755,
-0.016001094,
0.010548919,
-0.0015734521,
-0.008557166,
-0.01856288,
-0.027602894,
0.016229106,
0.031492516,
0.0015709373,
-0.020601578,
0.007524404,
0.03626736,
0.021500213,
0.009402152,
0.00026866884,
-0.014230647,
0.019072553,
-0.023123125,
0.0026892032,
0.015880382,
0.0074305166,
0.0049089696,
-0.01700703,
0.032726463,
-0.020923477,
-0.024518022,
-0.014981746,
0.02186235,
0.010830582,
0.008617521,
0.015907208,
0.033477563,
-0.000065700224,
-0.00847669,
-0.0004027937,
0.011400612,
-0.015384121,
0.03323614,
-0.012788804,
0.021285614,
0.006598943,
0.010569038,
-0.0012733478,
-0.0076518226,
-0.02687862,
-0.027133457,
0.012681505,
0.006230099,
0.011541444,
0.0031988777,
0.005364994,
-0.0031653466,
0.026959095,
-0.011286606,
0.01981024,
-0.00785301,
0.012956461,
0.0038795613,
0.014686671,
-0.013989222,
-0.6334985,
-0.030634116,
-0.00075109914,
-0.022224488,
-0.010817169,
0.032565515,
-0.0072360355,
0.0005645818,
-0.002903803,
0.039915554,
-0.019622466,
0.02757607,
-0.005227516,
-0.023351137,
-0.017570356,
-0.03055364,
-0.0019246916,
-0.018790891,
0.01738258,
-0.0028484766,
-0.017583769,
0.01435136,
-0.015625546,
0.0091204895,
0.00474802,
0.009804526,
0.015236584,
0.014257472,
-0.0072829793,
0.012044412,
-0.018697005,
0.021258788,
-0.011715806,
0.0017184747,
0.03967413,
-0.017704481,
0.0038627957,
0.022586625,
0.03616006,
0.019394454,
-0.016269345,
-0.0052610473,
0.020494277,
0.0065318802,
-0.028005268,
0.01565237,
-0.001492139,
-0.0034704804,
-0.0037588489,
0.0001547675,
0.006887311,
-0.0036884334,
-0.018482404,
0.0061395653,
-0.0023471848,
0.001591056,
0.010649513,
-0.009167434,
0.0025969925,
0.0005901494,
-0.010535507,
-0.027468769,
-0.0019951072,
-0.024531435,
-0.014042872,
0.011662155,
-0.0050967443,
0.009737465,
0.006682771,
0.014981746,
-0.002389099,
0.014793972,
-0.020051666,
0.0077390037,
-0.0042618173,
0.036937986,
0.027602894,
0.008054198,
-0.01808003,
0.0052711065,
0.00995877,
-0.0064379927,
-0.02821987,
0.0027612953,
0.016162045,
0.015840145,
-0.01413676,
0.014190409,
-0.00622004,
-0.009200965,
0.013908747,
0.00061655516,
-0.021003952,
-0.043778352,
-0.013318597,
0.03723306,
-0.01554507,
-0.0036146648,
0.012460198,
-0.022465913,
-0.034845635,
-0.020521102,
0.029641593,
-0.009898414,
0.01861653,
0.014954921,
0.009093665,
0.015840145,
0.04042523,
-0.014619608,
-0.004037158,
-0.022358613,
-0.01597427,
-0.017731305,
0.002099054,
-0.04208838,
0.028407644,
0.015357295,
-0.0030647528,
-0.012795511,
-0.009402152,
0.004680957,
0.024169298,
-0.014606196,
0.0025886097,
0.0029088326,
0.0087784715,
-0.02104419,
0.012567499,
-0.0046474263,
0.002419277,
0.0047681383,
0.01700703,
-0.034684688,
-0.0010361145,
0.01765083,
0.022640275,
0.005083332,
-0.022948762,
-0.030043967,
-0.04090808,
-0.008469984,
0.0027294408,
0.0013093939,
-0.018093443,
-0.018576292,
-0.042115204,
0.0057103657,
0.0126211485,
0.0052073975,
0.0035844867,
0.019260328,
-0.013788035,
0.035033412,
-0.005448822,
-0.0075646415,
-0.010381264,
-0.02082959,
0.0026456127,
-0.013311892,
-0.008094435,
0.0074036918,
-0.018804304,
0.011843224,
-0.011125657,
-0.019501753,
0.009777701,
0.003457068,
0.004754726,
-0.032109488,
-0.009542983,
-0.020172378,
-0.034631036,
0.029909842,
-0.02136609,
0.042678528,
-0.016779019,
-0.0033799463,
-0.0051839254,
-0.034040887,
-0.0059551434,
-0.011420731,
-0.0026657314,
-0.011286606,
0.0005167998,
-0.003929858,
-0.0016681779,
0.012091355,
-0.019126203,
0.014391596,
0.0070147295,
0.0037286708,
-0.011554856,
0.018120268,
-0.009469215,
-0.0071421484,
0.017208219,
-0.0001113865,
-0.023686448,
0.030741416,
0.009630164,
-0.0059283185,
0.0119505245,
-0.0024578378,
0.009502746,
-0.038145106,
0.008402922,
-0.025953159,
0.010569038,
0.013285067,
-0.011930405,
-0.033692162,
-0.013258241,
-0.027871145,
0.004895557,
0.027924795,
-0.007021436,
0.0013596907,
-0.01068975,
-0.0013731031,
-0.011125657,
-0.013345423,
0.049894445,
0.019407867,
0.010797051,
-0.039700955,
-0.0061227996,
0.0025433425,
0.0036381367,
-0.0020621696,
-0.014284297,
0.0065084086,
0.0044428855,
0.010381264,
0.016644893,
0.0045233606,
0.004147811,
0.00522081,
0.038332883,
0.010703163,
0.00063206337,
0.0042819357,
-0.0061295056,
0.023391373,
0.017825194,
-0.010267258,
0.017328931,
0.007443929,
0.018804304,
0.021795288,
-0.020762527,
0.0063407524,
0.00055913295,
0.0048284945,
0.008503515,
0.001037791,
0.023659624,
0.014552547,
0.021674575,
0.024598498,
-0.0034838931,
0.032136314,
0.008624228,
-0.022693925,
-0.0016044686,
0.010394676,
-0.0027495595,
-0.014968334,
-0.029105093,
0.00097492,
-0.02136609,
-0.0020202557,
0.011434143,
-0.00053985254,
0.0044261203,
-0.016229106,
0.009583221,
0.0031569637,
0.020668639,
-0.004674251,
-0.031009665,
-0.011534737,
0.02509476,
0.025349597,
-0.009623458,
-0.034228664,
-0.0051805726,
0.006240159,
-0.011796281,
-0.012788804,
0.018817717,
-0.024303423,
0.011695687,
0.011756043,
-0.023002412,
-0.012916223,
0.028327169,
-0.03428231,
0.003996921,
0.009361914,
0.020440627,
-0.010448326,
-0.004174636,
0.0012188596,
0.05255012,
-0.0081212595,
-0.01942128,
-0.0061462712,
-0.004033805,
0.0020638462,
-0.031814415,
-0.007839598,
-0.008074316,
-0.0048787915,
-0.0057673687,
0.016497357,
-0.025778797,
0.011179307,
0.043080904,
-0.0020353447,
-0.0033749165,
-0.021245377,
-0.002377363,
0.008443159,
0.030204916,
0.0117091,
-0.00849681,
0.00069996406,
-0.018603116,
-0.024571672,
0.0028937436,
-0.01938104,
0.02261345,
-0.0053415224,
-0.022412263,
0.009093665,
0.00532811,
0.017610593,
0.007899954,
0.018522643,
-0.008483397,
-0.013399073,
-0.0026556721,
0.027656544,
-0.006300515,
-0.011688981,
0.019273741,
0.019327391,
0.015169521,
-0.004258464,
0.021580689,
0.020199202,
-0.022841463,
-0.012943048,
0.025336184,
0.028970968,
0.018549467,
0.009361914,
-0.03353121,
-0.014016047,
0.006022206,
0.0061563305,
0.013070467,
0.010408089,
0.0007142148,
-0.0014946539,
0.017235043,
0.013023523,
0.016872907,
-0.00717568,
-0.019770004,
0.0050162696,
-0.023914462,
-0.0043389387,
0.028461294,
-0.019260328,
-0.0066794176,
-0.028353993,
0.0018844542,
-0.007953604,
0.0009858176,
-0.027468769,
-0.029909842,
-0.014512309,
-0.008812003,
-0.01581332,
0.019649291,
-0.0059383777,
-0.003083195,
-0.008040785,
-0.013640498,
-0.025000872,
-0.0224525,
-0.027133457,
-0.005536003,
-0.041417755,
-0.032109488,
-0.010428207,
0.029829366,
0.014633021,
0.0066525927,
-0.002152704,
-0.00093468255,
0.00763841,
-0.023766924,
0.007913366,
-0.014713496,
-0.03237774,
-0.016470531,
0.013211298,
0.016229106,
-0.025269123,
-0.01222548,
0.016202282,
-0.00004966811,
0.01317106,
0.018643355,
0.011688981,
-0.012554086,
0.026033634,
-0.010917763,
0.029239217,
0.010347732,
-0.017892255,
0.014257472,
-0.029346518,
-0.010931175,
-0.020051666,
-0.0023605975,
-0.0037454364,
-0.0056231846,
-0.0058310777,
-0.0022600037,
-0.020172378,
-0.005395172,
-0.0067095957,
0.008966247,
0.018576292,
0.047077823,
0.010964707,
-0.014847621,
0.035060234,
-0.009636871,
0.0038560894,
-0.012319367,
-0.006860486,
0.024115648,
0.018053206,
-0.016926557,
0.010059364,
0.0016111748,
-0.016886318,
-0.0063977554,
-0.0045032417,
-0.00511351,
0.04117633,
-0.0062166867,
-0.05574229,
-0.0116353305,
0.0056936,
-0.012527261,
0.005529297,
-0.012460198,
-0.011595094,
-0.006280396,
0.018267805,
0.0040975143,
-0.008060903,
0.018750655,
-0.03264599,
-0.019166442,
-0.006085915,
-0.016376644,
0.038118284,
-0.01808003,
-0.004815082,
-0.013399073,
-0.008523635,
-0.004721195,
-0.02136609,
0.019998016,
-0.004620601,
0.032780115,
0.013258241,
0.044180725,
0.003919799,
-0.009817939,
0.025014285,
-0.0081212595,
-0.0016941646,
-0.0051772194,
-0.0013831626,
-0.02568491,
0.006625768,
0.01888478,
0.016322995,
-0.013291772,
-0.047265597,
0.02218425,
0.02661037,
-0.012701623,
-0.013405779,
0.013211298,
-0.03221679,
-0.0011476057,
0.005026329,
-0.011393907,
-0.0025852565,
-0.019649291,
-0.0031955247,
0.010139839,
0.009898414,
0.004707782,
0.005968556,
0.027106633,
-0.0088790655,
0.027133457,
0.01640347,
0.015182933,
-0.0068738987,
-0.026060458,
-0.013472841,
0.014337947,
0.031546164,
-0.012775392,
0.0052409284,
0.0066492395,
0.023056062,
-0.0054924125,
-0.018240979,
0.007323217,
-0.008523635,
0.02002484,
-0.022318376,
-0.001743623,
-0.019085966,
-0.007189092,
-0.044717226,
0.022358613,
-0.002335449,
-0.00006915813,
0.014445246,
-0.0073433355,
-0.021540452,
0.018925017,
0.0051369816,
-0.0040304516,
-0.00643464,
0.01893843,
0.022009889,
-0.024061998,
-0.03487246,
-0.03168029,
-0.00426517,
-0.005411938,
0.04090808,
0.023015825,
-0.029212393,
-0.021594102,
-0.0017486528,
0.00574725,
-0.0034939523,
-0.038896207,
-0.008785178,
0.013486254,
-0.00031854652,
-0.014673259,
0.019595642,
-0.020252852,
0.008926009,
-0.020266265,
0.005452175,
-0.009757583,
-0.016738782,
-0.03723306,
0.013788035,
-0.008362684,
0.017717892,
-0.0043489984,
0.0029876311,
0.004670898,
0.0069543733,
-0.018925017,
0.01565237,
0.009073546,
0.027897969,
0.030902365,
-0.011186013,
0.004788257,
0.031277914,
-0.017208219,
-0.0055997125,
-0.010971413,
0.044341676,
-0.014995159,
0.015169521,
0.0154645955,
-0.008610816,
0.0063675772,
0.0044160606,
-0.0080072535,
-0.021567276,
-0.028675893,
0.0227744,
0.044502627,
0.022385437,
0.0063441056,
-0.0098782955,
-0.010079483,
0.009784408,
-0.005029682,
-0.02229155,
0.010461738,
-0.034791987,
-0.027978444,
0.021285614,
0.039030332,
0.043778352,
-0.011910287,
-0.0076249978,
-0.0081078475,
0.012165124,
-0.00779936,
0.017932493,
0.015115871,
-0.0039667427,
-0.04646085,
0.007866423,
-0.008302328,
-0.021929413,
-0.0126211485,
-0.01656442,
-0.027294407,
0.0005796708,
-0.0034436556,
0.010522095,
0.024531435,
-0.026623784,
0.014767146,
0.011112244,
0.0044898293,
-0.026851796,
-0.008483397,
0.008087728,
-0.0019112792,
0.008812003,
0.003423537,
-0.021178314,
-0.0010361145,
0.02784432,
-0.017838605,
0.011943818,
0.012285836,
-0.015437771,
-0.016604656,
0.011219543,
-0.021916,
0.010240433,
0.008309035,
-0.014820796,
-0.00036234668,
0.016591243,
-0.017610593,
-0.0034252135,
0.006132859,
-0.018240979,
-0.012989992,
-0.008409629,
-0.038010985,
-0.01527682,
-0.0013194532,
-0.02023944,
-0.034067713,
0.0019666057,
-0.038440183,
0.022465913,
0.010669632,
-0.049518894,
-0.014887858,
-0.010890938,
-0.022304963,
-0.0234182,
0.0026238174,
-0.007215917,
-0.0068437206,
0.007920072,
0.0029859545,
0.024410723,
-0.022747574,
0.009388739,
0.00015193831,
-0.015115871,
0.008630934,
-0.014472071,
0.024196124,
0.007108617,
-0.031116966,
0.0069879047,
0.020467453,
0.0049357945,
0.00014942346,
0.023431612,
0.003540896,
0.019461516,
-0.007578054,
0.013271654,
0.018254392,
0.01781178,
0.01899208,
-0.022412263,
-0.005026329,
0.01122625,
-0.020199202,
-0.020319914,
0.0054857065,
-0.004208167,
-0.002541666,
0.0052644005,
-0.0051302756,
-0.0072360355,
0.013238123,
-0.015773082,
0.0007762476,
0.00969052,
0.002114143,
0.020145552,
0.018495817,
-0.0004518331,
0.0010528801,
-0.020172378,
-0.025000872,
-0.009898414,
-0.001980018,
-0.014512309,
0.028139394,
-0.005777428,
0.0031150496,
0.00000350375,
0.02029309,
-0.0073902793,
-0.009891707,
-0.017342344,
0.009133902,
0.034926113,
-0.0027026157,
-0.023498675,
-0.0060993275,
-0.03390676,
-0.0048687323,
0.011420731,
0.011930405,
-0.037152585,
0.009864883,
0.0031804356,
-0.02530936,
0.003274323,
0.0031519341,
0.013057054,
-0.0027612953,
0.012473611,
0.20054348,
-0.013660616,
-0.0045133014,
0.029909842,
-0.0022482679,
-0.00763841,
0.009616752,
-0.01981024,
0.0013269978,
0.017516706,
0.029641593,
0.037447657,
-0.017717892,
-0.00046063503,
0.0017587121,
0.01699362,
-0.021795288,
-0.025121585,
-0.019890716,
0.01068975,
0.0058713155,
-0.0029524232,
-0.020252852,
-0.011125657,
0.04010333,
-0.019407867,
0.0050162696,
0.010233726,
-0.019179855,
0.01802638,
-0.0068336613,
-0.0116219185,
0.0128357485,
0.013090585,
0.007350042,
-0.0050129164,
-0.008329153,
0.008899184,
0.030419515,
0.00010970994,
-0.00895954,
-0.016577832,
-0.003789027,
-0.009536277,
0.009945358,
0.01533047,
-0.013238123,
-0.017556943,
-0.030929191,
0.0058109593,
-0.028756369,
-0.003732024,
0.011816399,
0.016792431,
-0.010850701,
-0.016041333,
0.00696108,
0.017114332,
-0.012326074,
0.010978119,
-0.038440183,
0.006501702,
-0.01991754,
0.017637419,
-0.025282534,
0.0110787125,
0.0009204318,
0.018254392,
0.0024645443,
-0.0009497716,
-0.028112568,
0.005250988,
-0.008362684,
0.0025768736,
-0.0108641125,
-0.022962175,
0.027656544,
0.014941509,
0.044824526,
0.011749337,
0.0020521102,
-0.0027981796,
-0.034335963,
-0.018281218,
-0.012460198,
-0.01122625,
0.021714814,
-0.008208441,
0.000047886762,
-0.0051101567,
-0.0063742837,
-0.012379724,
-0.005076626,
0.0017369168,
0.011514618,
0.0008843857,
-0.010314201,
0.0014954921,
-0.028085744,
-0.0011995791,
-0.049679846,
0.05429374,
0.0056768344,
0.022304963,
-0.002518194,
0.010535507,
-0.049357947,
0.01286928,
0.001964929,
-0.00906684,
0.0091204895,
-0.010958,
0.01602792,
-0.0074573415,
0.0011308402,
0.016752195,
0.017127743,
-0.03567721,
0.020869827,
0.019340804,
0.0057673687,
-0.032511864,
0.00097072864,
0.014458659,
0.013700854,
0.0066794176,
-0.020668639,
0.00089193025,
-0.0049391477,
-0.019595642,
0.018160505,
0.015303645,
0.020333327,
0.002724411,
0.025121585,
0.007128736,
-0.029748892,
-0.0060154996,
-0.0010050981,
-0.004509948,
-0.004835201,
-0.008127966,
0.0018173917,
0.03838653,
-0.003591193,
0.0011677245,
0.0026271706,
0.01704727,
-0.016376644,
-0.019072553,
0.0020135494,
-0.010032539,
-0.0074573415,
-0.014874446,
0.012909517,
-0.01797273,
-0.010039245,
-0.012433373,
-0.010253845,
0.023901049,
-0.039700955,
0.0064748772,
0.021889176,
0.0034050946,
0.0055225906,
0.016269345,
-0.1691046,
0.015451183,
0.022640275,
-0.02034674,
0.01850923,
0.0060456777,
0.052979317,
0.011809693,
-0.015746258,
-0.010569038,
-0.011051888,
0.024102235,
-0.03157299,
-0.018871367,
0.017744718,
0.032029014,
-0.01786543,
0.039298583,
0.014203822,
0.0059081996,
0.007303098,
-0.022358613,
0.023632798,
-0.017838605,
0.02034674,
0.011340256,
0.015075633,
0.000529374,
-0.00785301,
-0.016779019,
-0.0086778775,
-0.005777428,
0.026811559,
-0.012715036,
0.014002634,
0.006666005,
0.00348054,
0.01861653,
-0.011662155,
-0.009395446,
0.012366312,
0.03642831,
0.0030194856,
-0.0030446341,
-0.009402152,
0.011306725,
0.019595642,
0.0017771543,
0.031868063,
0.006025559,
0.015679196,
-0.011460968,
0.019099379,
0.02229155,
0.009563101,
0.0077188853,
-0.021875763,
0.052147742,
0.012983286,
-0.021218551,
-0.026368946,
-0.025510548,
0.014418421,
-0.005344875,
-0.028461294,
-0.020440627,
-0.004922382,
0.0123931365,
-0.022573212,
-0.0068236017,
-0.002392452,
0.0006555352,
-0.027897969,
-0.0070616733,
0.019957777,
0.012768686,
0.0021996475,
-0.010776931,
0.0052409284,
-0.012212068,
-0.008899184,
0.020226028,
-0.0007733136,
-0.029024618,
-0.0029356577,
-0.01759718,
-0.0023455084,
0.0029876311,
-0.026516482,
0.01570602,
0.031760763,
-0.021513626,
0.023217011,
-0.03342391,
0.0036649616,
0.025926333,
0.0131643545,
0.0224525,
0.0012666415,
0.017328931,
0.0058243717,
-0.017825194,
-0.010998238,
0.00822856,
-0.001602792,
-0.0073634544,
0.008604109,
-0.0018911604,
0.056010537,
-0.020641815,
-0.017878843,
-0.010877525,
0.011447556,
0.047158297,
-0.021728225,
0.021205138,
0.037313532,
0.01802638,
0.014874446,
-0.020963714,
0.059497785,
-0.011360375,
-0.00990512,
0.015142696,
-0.0119237,
0.002090671,
-0.12757955,
-0.010133132,
-0.014176996,
0.009978889,
-0.0021744992,
-0.00016933262,
0.012715036,
0.0076115853,
-0.009563101,
0.051047917,
-0.0020470805,
0.008946127,
-0.006645886,
-0.014445246,
-0.020977126,
0.0054354095,
0.0038493832,
0.0004281517,
-0.021392914,
0.020306503,
-0.0020940243,
-0.011239663,
0.0039399173,
-0.010059364,
-0.008000547,
0.031975366,
-0.012346192,
0.0130503485,
0.004805023,
0.0223452,
0.001938104,
-0.023351137,
0.014941509,
-0.0050196224,
0.015437771,
-0.012319367,
0.015048808,
-0.043832,
0.026140934,
-0.0005385951,
0.003919799,
0.00437247,
0.012956461,
0.018522643,
0.0026389065,
-0.010750107,
-0.015518245,
0.019501753,
-0.024021761,
-0.0043221735,
-0.025376422,
-0.014726909,
-0.025389835,
-0.003247498,
-0.0041075735,
-0.00020747438,
-0.011809693,
0.0031334918,
-0.03060729,
0.005700306,
0.008885771,
0.00039545874,
-0.026516482,
0.026087284,
0.023190187,
-0.01706068,
-0.023833986,
-0.020427214,
0.009797821,
-0.019448103,
-0.0056265374,
0.011930405,
-0.016068157,
0.007631704,
-0.03264599,
-0.015907208,
-0.021594102,
-0.008523635,
0.014431834,
-0.0069208425,
-0.0019816947,
-0.019944366,
0.004902263,
-0.009093665,
0.02757607,
0.01802638,
0.0015449506,
0.0024259833,
0.030580467,
-0.005002857,
-0.0065721176,
0.0452269,
0.007578054,
-0.011487793,
-0.018173918,
-0.0032458215,
-0.0031603167,
0.002778061,
0.014713496,
0.0038292645,
-0.04042523,
-0.014069697,
-0.04399295,
0.017235043,
0.022331787,
-0.0024008348,
0.0066592987,
-0.0154645955,
0.009824646,
0.012218774,
0.021768464,
0.009596633,
0.0077188853,
-0.0067095957,
-0.006598943,
-0.012728448,
-0.030848715,
-0.020158965,
0.040022857,
-0.022975586,
0.030258566,
0.043536928,
0.006940961,
0.0075109918,
0.033155665,
0.029909842,
0.0024293363,
-0.0044663576,
-0.025939746,
0.013338717,
-0.01413676,
0.006018853,
-0.00532811,
-0.015182933,
-0.03194854,
0.012017586,
-0.012138299,
-0.026449421,
-0.03409454,
0.024705797,
0.025228884,
0.017463056,
-0.0127351545,
-0.042437103,
-0.017717892,
0.004342292,
-0.000624938,
0.0015047132,
-0.048606846,
-0.01011972,
-0.00063206337,
-0.0050732726,
0.029668417,
0.0026808204,
-0.00027097412,
-0.018415343,
-0.020641815,
0.005700306,
-0.0034604212,
-0.0061529777,
-0.001892837,
-0.01597427,
0.029829366,
0.016859494,
-0.009160727,
-0.0091070775,
-0.0016857818,
0.005344875,
-0.022009889,
0.014525722,
-0.017208219,
-0.025014285,
-0.04321503,
0.029641593,
0.0071153236,
0.024115648,
0.008288916,
-0.00944239,
-0.00874494,
0.015947444,
0.015142696,
0.032189965,
0.01889819,
-0.027026158,
0.016296169,
0.02379375,
0.013593554,
0.0011861667,
-0.0012331103,
0.017288694,
-0.023833986,
0.010890938,
0.0030882247,
0.021071015,
-0.0022214428,
0.012212068,
0.010589157,
0.002598669,
0.011789574,
0.0012247276,
0.02736147,
0.021178314,
0.004949207,
-0.0055628284,
0.011145775,
-0.034443263,
-0.017610593,
0.02282805,
-0.025295947,
-0.029963491,
-0.006404462,
0.010086189,
0.018267805,
-0.01222548,
-0.010099601,
-0.010931175,
-0.013640498,
0.0044261203,
0.01695338,
-0.024585085,
0.009757583,
-0.0013722649,
0.01938104,
0.013734384,
0.00753111,
-0.012051118,
0.021513626,
0.023646211,
0.014458659,
-0.02762972,
0.029266043,
-0.0078932475,
0.020843001,
0.0150219835,
0.0019598994,
0.0034704804,
-0.008262091,
-0.024303423,
0.0015348913,
0.0012004174,
0.010843994,
0.092599794,
0.016229106,
0.004429473,
-0.012091355,
-0.032458212,
0.02423636,
0.006173096,
0.010937882,
0.004395942,
-0.038681608,
0.04139093,
0.007544523,
-0.00003059723,
-0.011206131,
-0.007765829,
0.024303423,
-0.037474483,
0.00076534995,
-0.021983063,
-0.016819257,
0.024906985,
-0.03739401,
0.012715036,
0.02272075,
-0.01808003,
0.0042819357,
0.02714687,
0.027817493,
0.0042048143,
-0.0007628351,
0.007081792,
-0.021661164,
-0.031546164,
-0.018388517,
0.014485484,
-0.0076786475,
-0.016846081,
-0.0015558483,
-0.01244008,
0.021956239,
-0.009885002,
0.012191949,
0.019448103,
-0.0150353955,
-0.023981523,
0.012976579,
-0.006055737,
-0.012272424,
-0.009610046
] |
BACKGROUND Both tumor-associated macrophages (TAMs) and the epithelial to mesenchymal transition (EMT) of cancer cells play key roles in promoting tumor progression. However, whether TAMs could induce EMT in the progression of oral squamous cell carcinoma (OSCC) remains undefined. RESULTS Here we detected the expression of macrophages markers CD68 and CD163, epithelial marker E-cadherin and mesenchymal marker vimentin in 127 OSCC patients by using semi-quantitative immunohistochemistry. CD68 and CD163 expression was not confined to the infiltrating TAMs
|
[
-0.027686145,
-0.019302677,
0.013661949,
-0.027116898,
-0.009547839,
0.0042111403,
-0.02421891,
0.006125883,
-0.037958484,
-0.0026521776,
0.022511166,
0.003174527,
0.014580508,
0.0075101904,
-0.025706716,
0.0061743986,
0.040882345,
-0.013933635,
-0.049472813,
-0.000642021,
-0.047997944,
0.0105375545,
-0.00771719,
-0.010938616,
-0.009942431,
0.025435029,
0.008085907,
-0.037130486,
-0.021036295,
-0.0053108237,
0.0130344825,
0.0048903567,
-0.022252416,
0.000022021462,
-0.017271498,
0.001260593,
0.020143611,
0.0023125694,
0.019833112,
-0.017581996,
-0.014891007,
0.000010650656,
0.0066886623,
-0.0056892443,
-0.010065337,
0.005537229,
0.0063070077,
-0.017853683,
-0.007691315,
0.0138560105,
0.021178609,
-0.0058347904,
-0.010602241,
-0.008642217,
-0.017763121,
0.0077236583,
0.013791323,
0.027944895,
-0.001951938,
-0.011540207,
0.005000325,
0.015822504,
-0.019250927,
-0.0101300245,
0.0023756395,
0.015317942,
-0.02634065,
0.016016565,
0.010097681,
0.015072131,
0.036561236,
0.037854984,
-0.019108616,
-0.0015023615,
0.028358893,
-0.02807427,
-0.024451783,
-0.010375836,
-0.0017417044,
-0.015589629,
0.0101300245,
-0.017905433,
-0.013312638,
0.033068124,
0.0061808676,
0.018461743,
0.006889193,
-0.0031324804,
0.0030613244,
0.001596158,
0.020272987,
0.024205972,
0.0015007444,
0.013086232,
-0.0101300245,
0.02269229,
-0.003486643,
0.052603677,
0.031205133,
-0.02467172,
-0.007238504,
0.00817,
-0.01533088,
-0.016133001,
-0.036923487,
-0.001394819,
0.025318593,
0.01918624,
0.024141284,
-0.010854522,
-0.011100333,
0.019910738,
-0.02274404,
-0.031282756,
0.009929494,
0.0041561564,
0.0051814495,
0.0027152477,
-0.018099494,
-0.0039103446,
0.0075619402,
0.0262889,
0.007406691,
-0.018823992,
0.027841395,
0.0092890905,
-0.010996833,
0.008389937,
-0.01807362,
-0.008111782,
0.014955694,
0.02446472,
0.029704388,
0.012989202,
-0.0063037733,
0.0093020275,
-0.03136038,
-0.006682194,
-0.024477659,
-0.0229381,
-0.0017142124,
0.023222726,
0.011585488,
-0.0109903645,
-0.012775733,
-0.009379652,
0.038889978,
0.013150919,
0.016197689,
0.035707366,
0.0126075465,
-0.03837248,
-0.0028850518,
-0.00868103,
0.013066825,
-0.011462582,
0.0033475657,
0.026379464,
-0.027116898,
-0.00964487,
-0.011883049,
-0.013183263,
0.027453272,
0.027841395,
0.019626115,
0.030196011,
0.015020381,
0.019470865,
-0.0023061007,
-0.017685495,
-0.019367365,
0.030791134,
-0.033508,
0.02451647,
-0.0029303327,
0.013137982,
-0.021799605,
0.017931307,
-0.029911388,
-0.053819798,
-0.012963327,
0.03177438,
0.023416787,
-0.008085907,
-0.016262377,
0.0006254449,
0.009657808,
0.005546932,
-0.009851869,
-0.03772561,
0.010589304,
0.04442721,
-0.004589561,
-0.010951553,
-0.63258964,
-0.051077057,
0.004350218,
0.0067792246,
0.01568019,
0.012937452,
0.011307333,
-0.008609874,
-0.033430375,
-0.0012791905,
-0.029989012,
0.012704577,
0.012853358,
0.0026796695,
0.013597261,
-0.02340385,
-0.0231451,
-0.010738085,
0.000035881214,
-0.006339351,
-0.017543184,
-0.006630444,
0.02908339,
0.017905433,
-0.00019648754,
0.009489621,
0.020415299,
-0.0010309531,
0.00401061,
0.046031453,
-0.027375648,
0.029652638,
-0.0048903567,
-0.010317617,
0.0468077,
0.0070185675,
-0.020065987,
0.016145939,
0.008706905,
0.033275124,
0.01680575,
-0.02446472,
-0.0042014373,
0.0039523914,
-0.027272148,
0.025629092,
0.006248789,
0.0047027636,
-0.0051911524,
-0.007497253,
-0.017077437,
0.013273825,
-0.03826898,
-0.0008530632,
0.027789645,
-0.0050294343,
0.03513812,
-0.025564404,
-0.0006974095,
0.005740994,
0.011954205,
0.025305655,
-0.00077058695,
-0.01588719,
-0.005294652,
0.028048394,
-0.014489946,
0.007128536,
0.011456113,
-0.00035881213,
0.011055052,
0.036483612,
-0.0053011207,
0.016521126,
0.01228411,
0.052008554,
-0.00964487,
0.0071802856,
0.011430238,
-0.009580183,
0.0065107723,
-0.005259074,
-0.024374159,
0.018655805,
0.0026683493,
-0.0065981,
-0.023132162,
0.009405527,
0.000335363,
0.004741576,
0.00323598,
-0.00009086538,
-0.016365876,
-0.053871546,
-0.027556771,
0.020997483,
-0.009838932,
0.012775733,
-0.01659875,
-0.030791134,
-0.011009771,
0.0067339432,
0.012691639,
-0.011611363,
0.03772561,
0.0077042524,
-0.027634395,
-0.005802447,
0.042408966,
-0.03863123,
0.013739574,
0.0032683236,
0.012717514,
-0.04080472,
-0.024839906,
-0.018422931,
0.020751672,
0.016547,
0.013390263,
-0.038967602,
0.0053690425,
-0.012678702,
0.02675465,
0.0049518095,
0.028358893,
0.014464071,
-0.0006375738,
-0.031308632,
-0.006536647,
-0.0060450244,
-0.006009446,
-0.027349772,
0.009269684,
-0.03268,
0.007620159,
0.011145614,
0.012711046,
-0.0036224865,
-0.005187918,
-0.02685815,
-0.013480824,
-0.010641053,
0.01390776,
-0.026573526,
-0.01628825,
0.009224403,
-0.017840745,
-0.0088944975,
0.006442851,
0.00058744114,
-0.0035319242,
-0.009230872,
-0.0005332656,
-0.0069409427,
0.026987523,
-0.0109580215,
-0.015499067,
0.0008110165,
0.0026133652,
-0.010647522,
-0.03136038,
0.018422931,
-0.0200013,
-0.004819201,
0.0020877812,
-0.00449253,
-0.016948061,
0.005605151,
-0.01182483,
-0.034180745,
-0.0059706336,
-0.019833112,
-0.0013317489,
0.008609874,
-0.01522738,
0.00515234,
-0.007639565,
-0.019509677,
0.009334371,
-0.013150919,
0.030635884,
-0.02604309,
0.018953366,
0.0025017797,
0.043961458,
0.010071806,
0.03203313,
-0.009489621,
0.016145939,
0.025305655,
-0.037647985,
0.013985385,
-0.0118183615,
0.009120903,
0.035086367,
-0.022291228,
0.016986873,
0.022045417,
0.014528758,
0.027996644,
-0.013623136,
-0.023158038,
0.015253255,
-0.0062973043,
0.00868103,
-0.005569573,
-0.0005158809,
-0.005766869,
0.024361221,
0.016508188,
0.008726311,
-0.0013107256,
-0.0084999055,
-0.010653991,
-0.00563426,
0.008234688,
0.0016090955,
-0.008182938,
-0.013726636,
-0.025008094,
-0.016741062,
0.0021007187,
0.026056027,
-0.015149755,
-0.0068050995,
0.02152792,
0.0325765,
0.019626115,
-0.018047744,
-0.012918045,
-0.002336827,
0.011255583,
0.016107127,
0.0004705998,
0.039200477,
-0.0043211086,
0.009618995,
-0.0059253527,
0.029937262,
0.00057652517,
0.0025066312,
0.026379464,
0.0015799863,
0.013118575,
-0.0056439633,
-0.007904783,
0.030273637,
0.01411476,
-0.000004706251,
-0.0036612987,
0.000027542621,
-0.0061194147,
-0.015460255,
-0.0027039272,
-0.0065560536,
-0.010162368,
-0.0041141096,
0.014373508,
0.04204672,
0.014399383,
0.013933635,
-0.018552305,
-0.0050294343,
-0.018487617,
-0.0060935398,
0.027065149,
0.021385606,
-0.014968631,
-0.004385796,
-0.014244134,
-0.024555283,
0.015201505,
0.015550816,
-0.04173622,
-0.019871926,
0.022187728,
0.011443175,
0.0038391887,
0.010466398,
0.013377325,
-0.008305844,
-0.037052862,
0.036949363,
0.018190056,
-0.018707555,
0.0025017797,
-0.022019543,
-0.005187918,
-0.015719004,
0.008331719,
0.026573526,
0.018474681,
-0.0029028407,
-0.008377,
-0.035396867,
0.0045863264,
0.013150919,
-0.016611688,
0.034335997,
0.0116243,
0.012833952,
0.0016818687,
-0.018707555,
-0.0074455035,
0.01522738,
0.0039976723,
0.0023918112,
-0.023869598,
-0.037544485,
-0.02298985,
-0.018979242,
-0.02045411,
-0.013752511,
0.0026376229,
0.0060903053,
0.0011465816,
0.010822178,
0.005666604,
0.04843782,
0.015421442,
0.016003627,
-0.025085717,
0.0029093095,
-0.020415299,
0.03234363,
0.022549978,
0.010725147,
0.0074649095,
0.012982733,
-0.004680123,
0.009153247,
-0.018513493,
0.005304355,
-0.02350735,
-0.02309335,
-0.0045313425,
0.0064040385,
-0.00077786425,
0.022161854,
0.034853496,
-0.007122067,
-0.026780525,
0.0046574823,
-0.021295045,
-0.02055761,
-0.006675725,
0.041399844,
0.031049883,
0.04315934,
-0.008098844,
0.0047383416,
0.018591117,
0.0043437495,
-0.012575203,
-0.0229381,
0.031205133,
0.0035060493,
0.010421117,
-0.0061743986,
-0.033947874,
0.019716676,
-0.012814546,
-0.011339677,
0.001127984,
-0.0032958158,
0.026780525,
0.012685171,
-0.0075101904,
0.008344656,
-0.0005692479,
0.0063975696,
0.009910088,
0.010479336,
-0.0166505,
0.02451647,
-0.017439684,
-0.006792162,
-0.019833112,
0.00079767476,
0.020479985,
-0.017426748,
-0.0020651408,
-0.011954205,
-0.00832525,
-0.014541695,
-0.02781552,
0.002477522,
-0.017788995,
0.0042402497,
0.00018496513,
-0.0015064045,
-0.011326739,
-0.0101300245,
-0.0030322152,
0.017129185,
-0.017827809,
-0.034128997,
0.006151758,
-0.0046607167,
0.014852194,
-0.0004948575,
-0.00857753,
0.013390263,
0.021709044,
0.008383469,
-0.0011417301,
-0.009250278,
-0.042667713,
-0.009800119,
-0.02822952,
0.024231846,
-0.013228544,
-0.011585488,
0.008583999,
0.012478172,
-0.013739574,
-0.002264054,
-0.014515821,
-0.011197364,
0.010020056,
0.007859502,
0.012801608,
0.00621968,
-0.010854522,
-0.0055242917,
-0.047195822,
-0.010731616,
-0.0017999229,
-0.003502815,
-0.011973611,
0.018448805,
0.010757491,
-0.010751022,
-0.006096774,
0.0049938564,
-0.008752186,
-0.012827483,
-0.007736596,
0.014528758,
0.0037130485,
-0.0016204158,
0.037880857,
0.009767775,
0.0025357404,
-0.0020198596,
0.004395499,
0.027220398,
0.008590467,
-0.02364966,
0.014257072,
0.0076525025,
-0.009399058,
-0.002380491,
-0.03534512,
-0.0070120986,
0.017737245,
0.001501553,
-0.029549139,
0.00695388,
0.0060191494,
0.005964165,
0.004599264,
-0.010867459,
-0.011540207,
-0.0058606653,
0.021993667,
-0.007898314,
-0.014257072,
0.0019632583,
-0.03619899,
0.008105313,
0.03055826,
0.030584134,
0.018099494,
-0.006623975,
0.004178797,
-0.006239086,
-0.00046534397,
0.005081184,
-0.039407477,
-0.007503722,
-0.010007119,
0.029885512,
0.034982868,
0.032938752,
0.005349636,
0.042305466,
0.01203183,
0.0003565885,
-0.0025810215,
-0.020518798,
0.027039273,
-0.0024581158,
0.019069804,
0.021100983,
0.013817198,
0.01411476,
0.007503722,
0.019069804,
-0.00069053646,
-0.0093020275,
0.014515821,
0.010188243,
-0.028772892,
-0.041917343,
0.013442012,
-0.018358244,
0.009703089,
-0.031438008,
-0.0037389235,
0.019367365,
0.036716487,
0.0062002735,
0.012419953,
0.022524104,
-0.0030225122,
0.0228346,
-0.021618482,
0.003226277,
0.0054596043,
-0.00022539466,
0.0016818687,
-0.011410832,
0.0118183615,
0.010582835,
-0.0019842817,
0.0151238805,
-0.030014887,
-0.0018791648,
0.02604309,
-0.016145939,
-0.01213533,
0.008454625,
-0.04015785,
-0.034853496,
-0.019755488,
-0.014916881,
-0.020065987,
-0.0068050995,
0.01456757,
-0.03268,
0.0049162316,
-0.014270009,
-0.0067533497,
0.043857962,
0.002370788,
0.032369502,
-0.023054538,
0.007471378,
0.0068762554,
-0.0058056815,
-0.014205322,
-0.0015589629,
-0.001181351,
0.0036289552,
0.023934284,
0.026625276,
0.0076719085,
-0.0016511423,
0.0048094974,
-0.009418464,
-0.006766287,
-0.013804261,
0.014580508,
0.014489946,
-0.0050294343,
-0.026017215,
-0.0037874389,
-0.044090834,
0.0036289552,
-0.015136818,
-0.017439684,
0.014438196,
-0.007186754,
-0.007743065,
0.03832073,
-0.0031049883,
0.0045345766,
0.018823992,
-0.029005766,
-0.007743065,
-0.03700111,
-0.007238504,
0.0075813467,
-0.002139531,
0.021980729,
-0.015408505,
0.017167998,
0.021941917,
0.0047739195,
-0.01588719,
-0.0063781636,
-0.011682519,
0.036742363,
0.0054596043,
0.0069280053,
0.017737245,
-0.0027427396,
0.005795978,
-0.00771719,
0.0030257464,
-0.015628442,
-0.03806198,
-0.0068309745,
0.040442474,
0.023817848,
-0.0044504832,
0.007451972,
-0.012898639,
0.0027864035,
-0.018371182,
-0.022123042,
-0.0042855307,
-0.029782014,
-0.021191545,
0.016016565,
0.03208488,
0.037570357,
0.0109580215,
0.0047383416,
-0.016844561,
0.034775868,
-0.0018047745,
0.0198978,
0.021411482,
0.014787507,
-0.004081766,
-0.004330812,
-0.015292067,
-0.044297833,
0.0053172926,
-0.027996644,
-0.022265354,
-0.017387934,
0.005598682,
0.014399383,
-0.012432891,
-0.009631933,
0.01736206,
0.011307333,
0.029807888,
0.002521186,
-0.013571386,
0.018966304,
-0.015292067,
-0.021411482,
0.010848053,
-0.015356755,
-0.01456757,
0.017594934,
-0.01913449,
0.005294652,
-0.023313288,
-0.011514332,
-0.022252416,
0.002854325,
-0.02913514,
-0.0032941985,
-0.0015775604,
-0.0011037263,
0.0032278942,
0.009974775,
-0.012096517,
-0.0059156497,
-0.024969282,
0.013377325,
-0.007633096,
-0.010576366,
-0.01548613,
0.0068956614,
0.006264961,
0.0010738084,
-0.022627603,
-0.0045960294,
-0.041451596,
0.0064493194,
0.0030063402,
-0.010524617,
-0.0019050398,
-0.010938616,
-0.060236774,
-0.036276612,
0.0061905705,
0.01659875,
0.009334371,
-0.009735432,
-0.00878453,
0.006374929,
-0.0015953495,
-0.0070832544,
-0.02593959,
-0.020298861,
0.012542859,
-0.020091861,
0.022304166,
0.013558449,
-0.011611363,
-0.011236177,
0.013053888,
0.012678702,
-0.014645195,
0.01548613,
-0.021036295,
0.00017354378,
-0.00056682207,
-0.0037647984,
-0.009910088,
0.010343492,
0.033068124,
-0.016559938,
0.0070120986,
0.016689312,
-0.0067792246,
0.006488132,
-0.003289347,
0.0031486521,
0.016158877,
0.015395567,
0.0034931118,
-0.020221237,
0.00954137,
-0.018047744,
0.012018892,
0.023235662,
-0.0053431676,
0.0117924865,
0.009586652,
-0.012594609,
-0.0142829465,
0.020583484,
-0.01772431,
-0.005229965,
0.0033119875,
-0.009547839,
-0.03136038,
0.0011797339,
-0.0043825614,
-0.024943406,
0.000067972156,
0.008655155,
-0.011747206,
-0.009534902,
-0.0037647984,
0.0076007526,
-0.012730452,
-0.011307333,
-0.0076266276,
-0.025447967,
-0.027142772,
-0.008719842,
-0.005107059,
0.006258492,
0.023002788,
-0.012652827,
0.01192833,
0.0166505,
-0.008997997,
-0.020376487,
-0.0030774963,
0.009476683,
0.1898183,
-0.019871926,
-0.0066433814,
0.00538198,
0.0064913663,
-0.007872439,
0.007988877,
0.012212954,
0.0038909386,
0.0065916316,
0.033585623,
0.011242645,
0.0016802514,
0.003190699,
0.021644356,
-0.024839906,
-0.01710331,
-0.0054757763,
-0.008260563,
-0.034128997,
-0.00058016385,
-0.022899289,
0.0122064855,
-0.0015250021,
0.021851355,
-0.0043534525,
-0.015072131,
-0.0020635235,
0.027686145,
-0.008868623,
-0.021838417,
0.021670232,
-0.01076396,
-0.0121870795,
-0.017478498,
0.007426097,
-0.008111782,
-0.00802122,
0.0024387096,
-0.004573389,
0.007833627,
-0.00700563,
-0.022291228,
0.018513493,
-0.0045151706,
0.008338188,
-0.014722819,
0.001493467,
-0.020182423,
-0.013079763,
-0.03410312,
-0.0028478564,
0.01548613,
0.011604894,
-0.0061291177,
-0.01953555,
0.01533088,
0.0089009665,
-0.0066951313,
0.011158552,
-0.023843722,
-0.0024807563,
-0.016935123,
0.012426422,
-0.018823992,
0.017025687,
-0.00310984,
0.015964815,
-0.012594609,
-0.011203833,
0.0025551466,
-0.018332368,
-0.00083203986,
-0.027479148,
0.008189407,
-0.010686335,
0.026884023,
-0.018823992,
0.0023853425,
0.038501855,
-0.012316453,
-0.024089534,
-0.0053464016,
-0.01538263,
-0.024451783,
-0.03645774,
0.019975426,
0.023882534,
0.0064396164,
0.0036612987,
0.00023651279,
-0.030066637,
0.0038359542,
0.00028907118,
0.025176281,
-0.00076169247,
0.017336184,
-0.002344913,
0.012905108,
0.0016964233,
-0.041658595,
0.047480445,
0.02451647,
-0.010886866,
-0.0029756138,
0.011055052,
-0.0021459998,
0.0027524428,
0.014075947,
-0.0134032,
0.010485805,
-0.0155120045,
-0.006843912,
-0.011650175,
0.0017239153,
0.026832273,
-0.0039362195,
-0.015059194,
0.03894173,
-0.010227055,
-0.015408505,
-0.023287412,
0.009586652,
0.019833112,
-0.02238179,
0.01030468,
-0.039433353,
0.002674818,
0.004599264,
-0.018371182,
0.0032570034,
-0.009489621,
-0.011087396,
0.023843722,
0.0065916316,
-0.0043017026,
0.016430562,
-0.026573526,
-0.011287927,
0.008001814,
-0.019354427,
-0.0010867459,
-0.00085063744,
0.021903105,
0.0008765123,
-0.018862804,
0.007594284,
0.012549328,
-0.019522615,
-0.034180745,
-0.03255063,
-0.016430562,
-0.0011546676,
-0.0041755624,
0.025396217,
-0.01066046,
-0.01670225,
-0.02116567,
-0.029419765,
0.004731873,
-0.02578434,
0.017491434,
0.010705741,
-0.021877231,
0.0056471974,
0.0013721784,
-0.16073489,
0.00538198,
0.011921861,
-0.018409993,
0.013998322,
0.010951553,
-0.007406691,
0.0045960294,
-0.013183263,
0.014425258,
0.0331975,
0.0032861126,
-0.04766157,
-0.0028284504,
0.010479336,
0.00969662,
0.010434055,
0.010899803,
0.008939778,
0.011934799,
0.0230416,
-0.02446472,
0.0023756395,
0.0030095747,
-0.014257072,
0.01401126,
0.018280618,
-0.0044634207,
-0.0018015401,
-0.010375836,
-0.0134032,
0.009010935,
0.0031340977,
0.01040818,
0.016689312,
0.01335145,
-0.007050911,
-0.009573714,
-0.005501651,
0.006407273,
0.03410312,
0.010078275,
-0.0034154872,
0.0101300245,
-0.019419115,
0.009010935,
-0.0057830405,
-0.011837768,
0.027893145,
-0.010544023,
0.0047900914,
-0.012652827,
0.012788671,
0.022756977,
-0.0051846835,
0.009463746,
0.005715119,
0.020906921,
0.027168648,
-0.016754,
-0.014127697,
-0.016210627,
0.024257721,
0.009890681,
-0.020014238,
-0.0537163,
-0.009101497,
-0.0005829939,
-0.029989012,
0.004026782,
-0.021463232,
-0.0008991529,
0.014981569,
-0.028721143,
0.01390776,
0.018940428,
-0.024244783,
0.023429725,
-0.013804261,
-0.005666604,
-0.0030435354,
0.008001814,
-0.031049883,
0.01060871,
0.005750697,
0.020130673,
0.012316453,
0.013817198,
-0.001951938,
-0.008241156,
0.018927492,
-0.033637375,
-0.011410832,
-0.017232684,
0.046341952,
0.032059003,
-0.013610199,
0.003431659,
-0.013312638,
-0.015848378,
0.029264515,
-0.030247761,
-0.027323898,
0.034698244,
0.015033319,
-0.0015654316,
-0.010032994,
0.004528108,
0.06489426,
-0.02370141,
-0.025874903,
0.00009834485,
0.0228346,
0.008402875,
0.011029177,
0.022330042,
0.015602566,
0.014632258,
-0.011656644,
-0.008551655,
0.05811503,
-0.010835116,
-0.002238179,
0.009276153,
0.0026408574,
-0.029497389,
-0.12440653,
-0.013713699,
-0.008674561,
0.004334046,
-0.020027176,
0.02050586,
-0.0045248736,
0.019406177,
-0.007587815,
0.021540856,
-0.016352938,
-0.018267682,
0.007025036,
-0.028669393,
0.025564404,
-0.0026861383,
0.024762282,
-0.00038852784,
-0.050481934,
0.026728775,
0.0037227517,
0.0016252673,
0.0109644905,
-0.029989012,
0.0061097112,
0.0053722765,
-0.0336115,
0.024697594,
0.01071221,
0.011566081,
0.0065851626,
-0.001127984,
0.028565893,
-0.0017708136,
-0.013881885,
0.0033993153,
0.02137267,
-0.019574365,
0.026521776,
-0.018720493,
-0.0034801743,
0.016611688,
0.007658971,
0.0069409427,
-0.007995345,
-0.008157063,
-0.06163402,
-0.0072061606,
0.032887,
-0.026780525,
-0.0138560105,
-0.009806588,
-0.011747206,
-0.0048806537,
0.009353777,
-0.028436517,
-0.008765123,
0.027013399,
-0.005446667,
0.0049421065,
-0.015007444,
-0.0056730723,
-0.0049518095,
0.009877744,
0.024438845,
-0.024736406,
0.012937452,
-0.013506699,
0.000068022695,
-0.01953555,
0.0003578014,
-0.017698433,
-0.013726636,
-0.019871926,
0.0055339946,
-0.0065204753,
0.0075101904,
-0.015020381,
-0.012154736,
-0.02451647,
-0.007691315,
-0.019703738,
0.008176469,
-0.009114435,
0.049058817,
0.004214375,
-0.00305809,
-0.010783366,
0.015977753,
-0.037363358,
0.005197621,
0.048593067,
0.0008684264,
-0.015977753,
-0.004563686,
0.0134549495,
-0.0009840549,
0.013325575,
0.012795139,
0.018642867,
-0.0142958835,
-0.004741576,
-0.051749807,
0.014632258,
-0.004663951,
0.011307333,
0.002619834,
0.003012809,
0.007833627,
-0.025033968,
0.022666415,
0.031541508,
-0.0068568494,
0.03234363,
-0.011197364,
0.003119543,
-0.0268064,
0.01659875,
0.01538263,
0.0030338324,
0.01634,
0.04538458,
-0.0048741847,
-0.010110619,
-0.0046768887,
0.005365808,
0.00563426,
0.0134549495,
-0.021954855,
0.030066637,
-0.026521776,
0.0053722765,
0.010751022,
-0.027841395,
-0.0009031958,
0.006843912,
-0.011210302,
-0.011236177,
0.006151758,
0.025331529,
0.01299567,
0.04233134,
-0.0118183615,
-0.021178609,
0.018811055,
-0.00032121266,
-0.001961641,
-0.0036645331,
-0.012736921,
0.0032505346,
0.0027750833,
-0.0072773164,
0.026004277,
-0.0017594934,
0.012788671,
-0.02593959,
-0.0055760415,
-0.009030341,
0.021450294,
0.0036871736,
-0.02071286,
-0.036923487,
0.0230416,
0.043469835,
0.0036063145,
0.022071293,
0.02288635,
-0.013985385,
-0.0097224945,
-0.004528108,
0.0028688798,
-0.03537099,
0.00024560944,
-0.023973098,
0.003083965,
0.018409993,
0.0014910413,
0.0027411226,
-0.013894822,
0.01720681,
0.0009395824,
0.01456757,
0.00023631063,
0.012827483,
-0.002755677,
0.028410643,
0.025667904,
0.011585488,
-0.01461932,
0.01994955,
-0.010893334,
0.0069215363,
-0.021204483,
0.024865782,
0.0071155983,
-0.0132997,
0.011456113,
0.0039362195,
0.013189732,
0.013558449,
0.012167673,
0.035603866,
0.005828322,
0.00426289,
0.00025207814,
-0.008713374,
-0.017556122,
0.015641378,
-0.04564333,
-0.019833112,
-0.028333018,
0.009347308,
0.023895472,
0.016766937,
0.011236177,
-0.019005116,
-0.026482962,
0.021540856,
0.0019826645,
-0.008150594,
-0.013429075,
0.032809377,
0.013215607,
-0.0035869083,
0.007950064,
0.0027540599,
0.012161205,
-0.009418464,
0.022549978,
0.0011150466,
0.027712021,
-0.013377325,
0.031955507,
0.0017546419,
-0.006365226,
-0.013674886,
-0.026418276,
-0.018836929,
0.0034154872,
0.020570548,
-0.009120903,
0.07177698,
0.021346794,
-0.027453272,
0.0155249415,
-0.025577342,
0.036017865,
0.028048394,
0.01807362,
-0.002940036,
-0.028358893,
0.012452297,
-0.02797077,
0.00449253,
-0.034077246,
-0.028358893,
0.008674561,
0.0006860892,
0.015343817,
-0.004081766,
-0.0069603487,
0.012005955,
-0.0070120986,
0.005042372,
0.018901616,
-0.019444989,
-0.009004466,
0.037803233,
0.017776059,
-0.024891656,
-0.027116898,
0.012711046,
0.0036127833,
-0.020091861,
-0.0019535553,
0.002362702,
0.0043696244,
-0.016883373,
-0.046523076,
0.018280618,
0.018565243,
-0.018655805,
0.0016390134,
-0.020570548,
-0.023520287,
-0.013946572,
-0.022459416,
-0.014050072,
-0.015369692,
-0.004867716
] |
Significant efforts have been directed to understanding the factors that influence the lineage commitment of stem cells. This paper demonstrates that cell shape, independent of soluble factors, has a strong influence on the differentiation of human mesenchymal stem cells (MSCs) from bone marrow. When exposed to competing soluble differentiation signals, cells cultured in rectangles with increasing aspect ratio and in shapes with pentagonal symmetry but with different subcellular curvature-and with each occupying the same area-display different adipogenesis and osteogenesis profiles. The results reveal that geometric features that increase actomyosin contractility promote osteogenesis and are consistent with in vivo characteristics of the microenvironment
|
[
0.0035000292,
0.012379546,
0.003086481,
-0.029560285,
-0.00265276,
-0.001664279,
-0.014188399,
0.0017163928,
-0.022593848,
-0.019715821,
0.020078938,
0.0034277423,
0.0033974827,
0.011996257,
-0.02077827,
0.0076455968,
0.04295521,
-0.006532715,
0.0009918431,
0.023225937,
-0.024691848,
0.012379546,
0.0048213657,
-0.021235527,
-0.012002982,
0.025418079,
0.021396913,
-0.037764,
-0.001448259,
-0.027233656,
0.015371886,
0.003742106,
-0.024301836,
-0.01732195,
-0.024503566,
0.027274003,
0.0046028243,
-0.009810841,
0.014363232,
-0.0069664367,
0.020953104,
0.0072824815,
-0.016098117,
-0.0080356095,
-0.0045322184,
-0.0018239826,
0.006751257,
0.0008476896,
-0.011633142,
0.029587181,
0.025660155,
0.013152847,
-0.013737867,
0.004791106,
-0.017671617,
-0.0062940004,
0.006297363,
0.0038227984,
0.012285405,
-0.0133276805,
0.018411297,
0.0061225295,
-0.014363232,
0.010516899,
-0.01648813,
0.011787802,
-0.031927258,
0.013502514,
0.009857911,
0.0032478657,
0.029694771,
0.023911823,
-0.00070605776,
0.014322886,
0.005520699,
-0.015936732,
-0.031631388,
-0.0015339946,
0.0024627966,
-0.0046734298,
-0.015735002,
-0.020737926,
0.0024106828,
0.016824348,
-0.005349228,
0.0069866097,
-0.0199579,
-0.00016085929,
0.017792655,
0.008432347,
0.018209565,
0.032276925,
0.019191323,
-0.0033167903,
-0.008331481,
-0.008593732,
0.007107648,
0.0152911935,
-0.007484212,
-0.012392995,
-0.025256695,
0.0257274,
-0.0016726844,
-0.020737926,
-0.046693955,
-0.007235411,
0.018935796,
-0.001832388,
0.028000234,
-0.012480412,
-0.016972283,
0.017133668,
-0.005298795,
-0.029856157,
0.017281605,
0.016784001,
0.0020425243,
0.01636709,
-0.008102853,
0.006754619,
0.021033797,
0.026386388,
0.01846509,
-0.02215004,
0.0325728,
0.011343994,
-0.013737867,
0.018075079,
-0.029694771,
0.0038227984,
0.01170711,
-0.007699392,
0.015560168,
0.027865747,
-0.01670331,
-0.021450708,
-0.0041993624,
-0.0056350133,
-0.009602386,
-0.025956027,
-0.016568823,
0.0293989,
-0.01605777,
-0.0010036107,
-0.0048953337,
-0.003997632,
0.033756286,
0.001198617,
0.009824289,
-0.007390071,
0.016474681,
-0.025498772,
0.040292364,
0.009212373,
0.01638054,
0.0024829698,
-0.014148053,
0.028107824,
-0.019836862,
-0.010140334,
-0.011693661,
-0.0011473439,
0.012856975,
-0.003195752,
0.015681207,
0.019904105,
0.012150918,
-0.0067075486,
0.014578411,
-0.007517834,
-0.007255584,
0.018357502,
-0.027341247,
0.0033941206,
-0.004656619,
0.01312595,
0.004427991,
0.013374751,
-0.04884575,
-0.013905976,
0.0006009896,
0.008210443,
0.023979066,
0.008748392,
-0.008983744,
-0.001795404,
0.024974272,
-0.0056182025,
0.008896328,
-0.015318091,
-0.009683078,
0.004569202,
-0.012729213,
-0.005779587,
-0.64639926,
-0.038301952,
0.0009472942,
-0.015936732,
0.013825283,
0.027677463,
0.0066941,
-0.014632206,
-0.000022261307,
-0.0050533563,
-0.021692785,
0.010900187,
0.008291136,
-0.02614431,
-0.013314232,
-0.025606362,
-0.0038665067,
-0.017806103,
0.019984797,
0.0019214858,
-0.020442054,
-0.0014095939,
-0.004559116,
0.020711027,
0.002973848,
0.015896386,
0.018545784,
0.0054500937,
-0.01092036,
0.030582387,
-0.0004244752,
0.016689861,
-0.020455502,
0.0022930065,
0.045483567,
0.010718629,
-0.020415155,
0.017362297,
0.011256578,
0.028269207,
-0.016999181,
-0.019662028,
0.017859899,
-0.0021198543,
-0.013946322,
0.0068487604,
0.016743656,
-0.005927523,
0.0064789206,
0.014928078,
-0.00053962984,
-0.0011406195,
-0.014201848,
-0.000317726,
0.020253772,
-0.030958952,
0.034374926,
-0.025149105,
0.011162437,
0.007497661,
0.0009851187,
0.026520874,
-0.023858028,
-0.02457081,
-0.002691425,
0.033836976,
-0.018330604,
0.0020307566,
-0.0042598816,
-0.0113103725,
0.0162864,
0.04177172,
-0.0061191674,
-0.009279616,
-0.007464039,
0.043251082,
0.0019029938,
-0.014161501,
-0.0019870482,
-0.00043161982,
0.012702315,
-0.003308385,
0.003930388,
-0.00475076,
0.003442872,
0.0075111096,
-0.025122207,
0.020213425,
0.0024476668,
0.016582271,
0.013704245,
0.004074962,
-0.005685446,
-0.06934159,
0.012171091,
0.017052976,
-0.002657803,
0.023225937,
0.015183604,
-0.0225804,
-0.012251783,
0.013435271,
0.012930944,
0.01773886,
0.011377617,
0.011411238,
-0.029587181,
0.0022106331,
0.044246286,
-0.03703777,
0.03286867,
0.010274821,
-0.006149427,
-0.0078069814,
0.005312244,
-0.026440183,
0.0042195357,
0.015519822,
-0.022486258,
-0.012514033,
0.014363232,
0.0020257132,
-0.02005204,
0.0046465322,
0.010355514,
0.014053912,
0.006374693,
0.014995322,
-0.007759911,
-0.023104899,
-0.0020996812,
0.0019399778,
0.01605777,
-0.037898492,
0.031873465,
0.020011693,
0.0028511283,
-0.011370892,
0.017174015,
-0.035827387,
-0.02478599,
-0.015412232,
0.008587007,
-0.05019062,
-0.017496783,
-0.003178941,
-0.0142825395,
0.004078324,
0.020307565,
-0.012056776,
-0.0079885395,
-0.0061628753,
-0.020199977,
0.0039404747,
0.0060451995,
0.004145568,
-0.018491989,
-0.019097181,
0.015237398,
-0.026978131,
-0.025754297,
0.021020347,
-0.03278798,
0.009972225,
-0.0024880131,
-0.024422875,
-0.02309145,
-0.0059914044,
0.010268097,
-0.026292246,
0.01065811,
-0.0034243802,
-0.0036446028,
0.009319962,
-0.034832183,
0.020213425,
-0.019594783,
0.0030612648,
-0.022217285,
-0.009757046,
0.014928078,
-0.011148988,
-0.015250848,
-0.012285405,
0.03138931,
0.02215004,
0.031227926,
0.022499707,
0.0019567886,
0.028323002,
-0.017052976,
0.011122091,
-0.011196058,
0.013946322,
0.011955911,
-0.034052156,
-0.014497719,
-0.0054837153,
0.02477254,
0.024503566,
0.016770553,
-0.011081745,
0.025485322,
0.0005917436,
0.017913694,
-0.027462285,
-0.007026956,
-0.006905917,
0.007423693,
0.028430592,
0.0029519938,
-0.0026493976,
-0.019904105,
-0.01921822,
0.008815635,
-0.005255087,
-0.0062704654,
-0.02174658,
-0.010160508,
0.0010061323,
-0.0065898723,
0.000448851,
0.010099988,
-0.020589989,
-0.0027737983,
0.015627412,
0.012709039,
0.015977079,
-0.01159952,
-0.011680213,
0.0020862326,
0.0042195357,
0.008815635,
-0.0006896671,
0.002674614,
0.017510232,
0.0013709288,
-0.021854168,
0.011391065,
-0.0049760262,
0.022795578,
0.018518886,
-0.016999181,
0.009474623,
-0.003927026,
-0.010685007,
0.048334695,
0.0005841787,
0.007914571,
0.0069260905,
-0.024395976,
-0.0018559232,
-0.0062570167,
-0.00069218874,
0.01437668,
-0.0107589755,
-0.00070353615,
0.037441235,
0.02267454,
0.0015163431,
0.019514091,
0.003853058,
-0.006596597,
-0.022069348,
0.006899193,
0.008392001,
0.0095485905,
-0.019783067,
-0.026319142,
0.016219156,
-0.019393053,
0.00661677,
0.021477604,
-0.043035902,
-0.01636709,
-0.007625424,
0.035746697,
0.011330546,
0.0031066542,
0.020294117,
0.006004853,
-0.020724475,
0.007161443,
0.026023272,
-0.013139399,
-0.00060056936,
-0.030582387,
-0.011391065,
-0.020845514,
-0.00067117513,
0.0126216225,
-0.018935796,
0.0038362471,
-0.009111507,
-0.031039644,
0.013973219,
-0.009037539,
-0.00718834,
0.031981055,
-0.010200853,
0.016716758,
-0.023911823,
-0.016985733,
0.0003519782,
0.055623904,
0.013784938,
-0.010530347,
-0.00939393,
-0.008217167,
-0.039646823,
-0.02122208,
-0.019406501,
-0.025391182,
0.014228744,
0.009972225,
0.006095632,
0.0018811396,
-0.007948193,
0.045322184,
-0.014295989,
0.0040984973,
-0.023145245,
-0.006394866,
-0.020415155,
0.034321133,
0.03222313,
0.006825225,
0.007759911,
-0.0070000584,
0.013892527,
0.002170287,
-0.021491053,
0.010328616,
0.001470113,
-0.0067209974,
-0.018814757,
0.0030965675,
-0.0075447313,
-0.00061233697,
0.038409542,
-0.00012702735,
-0.010664835,
-0.008513039,
-0.00013333144,
-0.013253713,
-0.003631154,
0.027542977,
0.04284762,
0.020670682,
0.0022375307,
-0.002674614,
0.024140451,
-0.020980002,
-0.012930944,
-0.0045423047,
0.01870717,
-0.0078069814,
0.015344989,
-0.018559232,
-0.024732195,
0.0044010933,
0.0006934496,
-0.012379546,
0.016003976,
0.011323822,
0.0129242195,
0.015318091,
-0.0127695585,
-0.0047574844,
0.005648462,
0.008694597,
-0.005742603,
0.012413167,
-0.00601494,
0.013240264,
-0.057937082,
0.003160449,
-0.0030259618,
0.0049087824,
0.008829084,
-0.008627353,
0.011169162,
-0.012325751,
-0.0051105134,
-0.019272014,
-0.01985031,
0.027058823,
-0.02236522,
0.0039707343,
-0.015627412,
-0.025391182,
-0.011458308,
-0.018491989,
0.009837738,
0.02886095,
-0.004562478,
-0.039835107,
0.0021618817,
0.0040884106,
0.03138931,
0.019917553,
-0.021961758,
0.00044338746,
0.015708104,
0.0070202313,
-0.023064554,
-0.005147497,
-0.021625541,
0.011781078,
0.021867618,
-0.008956847,
-0.019285463,
-0.009017366,
0.0069664367,
0.02340077,
0.011787802,
-0.006095632,
-0.012460238,
-0.033568002,
0.004767571,
-0.004915507,
0.0068588466,
-0.012856975,
-0.008385276,
-0.028188515,
-0.034509413,
0.0013843775,
-0.019688925,
0.0010582461,
-0.00001423673,
-0.005870366,
0.018411297,
-0.016716758,
-0.018505437,
0.009810841,
-0.015560168,
0.000071393784,
-0.016582271,
-0.0017903608,
0.014820488,
0.0044212663,
0.009965501,
0.008519763,
-0.008687872,
-0.0036008945,
-0.010348789,
0.029022336,
-0.0062771896,
-0.026803298,
-0.011357443,
-0.00845252,
-0.0100529175,
-0.039566133,
-0.005389574,
-0.024005964,
0.022082796,
-0.009279616,
-0.0074505904,
-0.005080254,
-0.013475616,
0.0113103725,
0.017967489,
0.005853555,
-0.0047440357,
-0.0057896734,
0.00003199324,
-0.0066403053,
-0.0304479,
0.026278798,
-0.039404746,
-0.019823411,
0.01291077,
-0.0032243305,
0.010604315,
-0.021544848,
0.0117138345,
-0.011485206,
-0.021235527,
0.0011490249,
-0.03066308,
-0.003012513,
-0.027811952,
0.03329903,
0.024019413,
0.033998363,
0.0040245294,
0.011343994,
0.028403696,
0.0024493479,
0.005238276,
0.02142381,
0.010510174,
-0.030501695,
0.031954158,
0.008318033,
0.003384034,
0.01511636,
-0.012325751,
0.008660975,
0.03370249,
-0.007813706,
-0.021074142,
0.0040144427,
-0.035020463,
-0.026050169,
0.014134604,
-0.0044548884,
-0.012836803,
-0.030905157,
-0.00003094256,
0.0094477255,
0.012466962,
-0.01880131,
-0.015560168,
0.0068487604,
0.0010498406,
0.031147234,
-0.016192257,
0.0066436674,
-0.003121784,
-0.008257514,
-0.004202725,
-0.020589989,
0.010880014,
-0.0049995612,
0.010274821,
0.03539703,
-0.018249912,
-0.00015749711,
-0.0022509794,
-0.030797567,
-0.020724475,
-0.013905976,
-0.030824464,
0.0121172955,
-0.02216349,
-0.016837796,
-0.029936848,
-0.024853233,
0.0034495965,
-0.019500643,
0.008687872,
-0.021262424,
-0.004787744,
0.025323939,
0.0017920418,
0.025041515,
-0.0006812617,
0.036150157,
0.023064554,
-0.016246052,
-0.014336335,
0.003422699,
0.0037690036,
-0.014269091,
0.034186643,
0.0123392,
0.0036614137,
-0.019675476,
-0.00653944,
0.0064822827,
-0.020226873,
-0.015573617,
0.01616536,
0.010274821,
0.0066268565,
-0.0140808085,
-0.00022547618,
-0.033110745,
-0.0089433985,
-0.0123190265,
-0.0008249949,
-0.00923927,
-0.009279616,
-0.017241258,
0.020280669,
-0.0013826964,
0.007457315,
0.012345924,
-0.024436323,
-0.0059039877,
-0.028511284,
-0.019702373,
0.018128874,
0.005345866,
0.012332476,
-0.030474797,
0.015869489,
0.013361302,
0.03138931,
-0.00740352,
0.0015197053,
-0.0022291252,
0.0409379,
-0.0036076189,
-0.019756168,
0.013334405,
-0.0023014122,
0.02531049,
-0.01553327,
-0.017174015,
-0.0015819056,
-0.041933108,
0.0004593578,
0.01857268,
0.0070067826,
-0.002262747,
-0.0033537743,
-0.022082796,
-0.017806103,
-0.017900245,
-0.010039469,
-0.019339258,
-0.023252835,
0.0043136766,
0.01878786,
0.018330604,
0.027179861,
0.0045221318,
-0.004424629,
-0.009279616,
0.02614431,
-0.009931879,
0.045402877,
0.024194246,
0.023898374,
-0.0451339,
0.0009859592,
-0.011438136,
-0.027758157,
-0.0017298415,
-0.018303707,
-0.014215296,
-0.0071547185,
-0.0021938223,
0.029694771,
-0.0060687345,
0.00022127345,
-0.007047129,
0.0056988946,
0.016824348,
0.005759414,
-0.020482399,
0.002938545,
-0.00840545,
-0.0050432696,
-0.009010642,
-0.027233656,
0.0009683078,
-0.017698515,
-0.016151913,
-0.002841042,
-0.012144193,
0.01170711,
-0.0035975324,
0.007262308,
-0.030501695,
0.023360426,
-0.013031809,
-0.019339258,
-0.016958835,
0.007443866,
0.0042363466,
-0.018196117,
-0.005584581,
0.009535142,
0.010940533,
0.016205706,
-0.020388259,
-0.00015182343,
0.010927084,
-0.019366156,
-0.026615014,
0.010247924,
-0.027152965,
0.046667054,
-0.00050474727,
-0.0075312825,
-0.014000117,
0.009649456,
-0.061057184,
-0.041717928,
0.017711964,
-0.0028830692,
-0.00587709,
0.0009590618,
-0.014981873,
0.011216232,
-0.010644661,
-0.007410244,
0.01365045,
-0.0018290258,
0.015318091,
-0.021275874,
0.013764764,
-0.009172026,
-0.020724475,
-0.0127224885,
0.04230967,
-0.0004261563,
-0.013946322,
0.016138462,
0.010281546,
0.0367419,
-0.0072219623,
0.04462285,
0.028591977,
0.015479476,
0.018397847,
-0.042524848,
-0.008620629,
-0.013152847,
-0.012413167,
0.018438194,
0.0002336715,
-0.043762133,
0.009414104,
0.017496783,
0.025458425,
-0.0014255642,
0.014497719,
-0.0028359985,
0.018330604,
0.00086029776,
0.017886797,
0.026843643,
0.017174015,
-0.003923664,
-0.008499591,
0.020347912,
0.00017189144,
0.00054719474,
0.009427552,
0.00046818354,
-0.010624488,
-0.010362238,
-0.00882236,
-0.019164424,
0.014780142,
0.002842723,
-0.011471758,
0.00404134,
0.024960823,
-0.008728218,
-0.014659104,
-0.009602386,
-0.01585604,
-0.024584258,
-0.018330604,
0.011875219,
-0.007309379,
-0.01275611,
-0.004599462,
0.00085609505,
0.00609227,
0.0078338785,
0.009037539,
0.015412232,
-0.0036580516,
0.014403578,
0.191187,
-0.01679745,
0.0066840136,
0.012043328,
0.0025703865,
-0.020899309,
0.01249386,
-0.007195065,
-0.0031032918,
0.0072892057,
0.017106771,
0.013986668,
-0.013105777,
-0.009017366,
0.033218335,
-0.005443369,
-0.017819554,
-0.01013361,
-0.0057022567,
-0.031416208,
-0.011781078,
-0.0145380655,
0.017052976,
-0.004229622,
0.02373699,
-0.002524997,
-0.022809027,
-0.005369401,
0.005594667,
0.009474623,
-0.01985031,
-0.014470822,
-0.013092328,
0.0022694713,
-0.0016441059,
-0.010321892,
0.0016298166,
0.0010036107,
0.011781078,
0.009669629,
-0.0030848,
-0.003990907,
0.010160508,
0.005759414,
0.0044044554,
0.017133668,
-0.014013565,
0.01264852,
0.0057022567,
0.0011112004,
-0.022338323,
0.012305578,
0.016205706,
0.010422757,
0.0044078175,
0.0032629955,
0.0058602793,
0.018545784,
0.014887732,
-0.004021167,
-0.030421002,
-0.0002330411,
-0.0014751564,
0.010120161,
-0.0116129685,
-0.0028931557,
-0.0123190265,
-0.008768565,
0.0016668006,
-0.031416208,
-0.0053962986,
-0.022916617,
-0.018949246,
0.0018374312,
-0.020186527,
-0.034993567,
0.028296106,
0.004037978,
0.011498655,
0.016945386,
0.021087592,
-0.0049592154,
-0.041099284,
0.0013179745,
0.005440007,
-0.020294117,
0.020065488,
0.024194246,
-0.0082373405,
-0.0147397965,
-0.006952988,
-0.00037845536,
0.006805052,
-0.00871477,
0.0037286575,
-0.012783008,
0.015318091,
-0.0019534265,
-0.009709976,
-0.0035403753,
-0.038490236,
0.063047595,
0.009696526,
-0.0012070226,
0.0027788416,
0.007067302,
-0.015197053,
0.0027334522,
0.0071681673,
0.006098994,
0.029156823,
-0.036688104,
0.0013591612,
-0.017268155,
0.0039740964,
-0.00456584,
0.026507426,
-0.018613027,
0.05890539,
-0.01028827,
-0.015062565,
-0.016246052,
0.007699392,
0.034912873,
-0.0015642542,
0.005456818,
-0.0017079873,
-0.001813896,
-0.003742106,
-0.016649514,
-0.021558296,
-0.019312361,
-0.0048886095,
0.0009935241,
0.0007161443,
-0.010624488,
-0.0018004472,
0.005160946,
-0.003927026,
0.007625424,
-0.03445562,
-0.011626418,
0.006808414,
-0.00797509,
0.0023333528,
-0.017779207,
0.01837095,
0.021854168,
-0.005288709,
-0.035612207,
-0.015264296,
-0.0054769907,
-0.007275757,
-0.0036580516,
0.019796515,
0.0004929796,
-0.02436908,
-0.022405567,
0.007161443,
0.012043328,
-0.01149193,
0.017295053,
0.006337709,
-0.022553502,
-0.0025334025,
-0.00860718,
-0.17031458,
0.011296924,
0.041825518,
-0.020065488,
0.034267336,
0.0050768913,
-0.0064621097,
0.0004854147,
-0.017523682,
-0.0024375804,
0.045940824,
0.013045258,
-0.037629515,
-0.020845514,
0.011169162,
-0.0029603993,
0.012695591,
0.03106654,
0.022459362,
0.024005964,
0.026951233,
-0.033783183,
0.023024207,
0.005446731,
0.017442988,
-0.008627353,
0.007941469,
0.013448719,
-0.009010642,
-0.024315285,
0.016313296,
-0.007739738,
0.014524616,
0.0027704362,
-0.0015802245,
0.009219097,
-0.008990468,
-0.0043842825,
-0.01159952,
0.015882937,
0.021544848,
0.011660039,
-0.013879078,
0.0022224009,
-0.005389574,
0.012917494,
-0.011411238,
-0.013522687,
0.03959303,
-0.01317302,
0.019715821,
-0.026117412,
0.014188399,
0.009084609,
0.032196235,
0.014148053,
0.020105835,
0.006747895,
-0.008022161,
-0.020428604,
-0.0031066542,
-0.015600515,
0.03370249,
-0.005349228,
-0.012083674,
-0.0055408725,
0.0043103145,
0.018303707,
-0.029210618,
0.009427552,
-0.0073026544,
-0.0023098176,
0.0067109107,
-0.017496783,
0.026426733,
0.016985733,
-0.008425622,
0.006098994,
-0.009931879,
-0.0003856,
-0.031254824,
0.020818617,
-0.02278213,
-0.017792655,
0.008196995,
0.0018945883,
-0.005440007,
0.015076014,
-0.012157642,
-0.0068655713,
0.01659572,
-0.042067595,
-0.007901123,
0.0009599023,
0.04690913,
0.0123392,
-0.003920302,
-0.036177054,
-0.01639399,
-0.013838732,
0.009891533,
-0.0031453192,
-0.02130277,
0.03970062,
0.015708104,
-0.005103789,
-0.00326972,
-0.002600646,
0.047070518,
-0.004713776,
-0.016649514,
0.012312302,
0.014269091,
0.009124956,
-0.006697462,
0.019756168,
0.007477488,
0.0023989154,
0.0066941,
-0.02708572,
0.058259852,
0.0072488594,
0.0003194071,
0.03138931,
0.012870424,
-0.012917494,
-0.13524032,
-0.020912759,
-0.014887732,
0.022513157,
-0.002788928,
0.038275056,
-0.014874283,
0.010073091,
-0.018276809,
0.03663431,
-0.031981055,
-0.031658284,
-0.004360747,
-0.010106713,
0.019285463,
-0.014712899,
0.0000054996594,
-0.002901561,
-0.006623494,
0.021020347,
-0.0006627697,
-0.015264296,
-0.018653374,
0.0005156743,
0.016246052,
0.028215412,
-0.04629049,
0.0033991637,
0.021544848,
0.033137646,
0.010745526,
0.0026662087,
0.017362297,
-0.011673489,
-0.0139328735,
-0.016407438,
0.004320401,
-0.020401707,
0.023763888,
-0.0021215354,
0.0031856652,
0.021491053,
0.016770553,
-0.018182669,
-0.0057863113,
-0.0017332037,
-0.029963747,
-0.0061696,
0.022392116,
-0.011787802,
-0.029802362,
-0.00956204,
-0.012971289,
-0.009709976,
0.024490118,
-0.003274763,
0.010900187,
0.0097503215,
-0.0006884063,
0.0070000584,
-0.017335398,
0.009158578,
-0.006075459,
0.008566834,
0.033836976,
-0.013099052,
-0.026601566,
-0.027206758,
0.011626418,
-0.02867267,
0.0014255642,
0.019285463,
-0.00902409,
0.009817565,
-0.012433341,
-0.0019231668,
-0.024517015,
-0.026023272,
-0.00095822127,
-0.021827271,
0.0001130533,
-0.021921413,
0.018128874,
-0.013852181,
0.023360426,
0.0067142732,
0.016824348,
-0.002540127,
0.008788738,
-0.0039942698,
0.0033907583,
0.031470004,
0.0059006256,
-0.031873465,
-0.0068487604,
0.009380481,
0.012137469,
0.0020475674,
0.012702315,
0.015869489,
-0.0273009,
-0.00945445,
-0.036661208,
0.029775465,
0.0018071716,
0.005218103,
-0.007813706,
-0.018666822,
0.016689861,
-0.021598643,
0.004569202,
-0.0114650335,
0.002615776,
0.0019551076,
-0.012433341,
-0.012830078,
-0.03612326,
-0.039324056,
0.025942579,
0.001047319,
0.012702315,
0.0121172955,
0.010368963,
-0.009817565,
-0.00300747,
0.0007102605,
-0.025525669,
0.011666764,
-0.013334405,
0.013287335,
-0.022499707,
-0.0031856652,
0.0032512278,
-0.038167465,
-0.0010960706,
0.03128172,
-0.020213425,
-0.0024594346,
0.01244679,
0.031362414,
0.0273009,
0.023468016,
0.0077262893,
-0.026332593,
0.01533154,
0.007813706,
0.01636709,
0.028000234,
-0.031012746,
0.00595442,
-0.024839785,
-0.015479476,
0.026951233,
0.006115805,
-0.0012389632,
-0.03854403,
0.012399719,
0.0034664073,
0.0036849491,
0.008479417,
-0.0004568362,
-0.011740732,
0.019769616,
0.019554438,
0.003330239,
-0.008257514,
-0.017496783,
0.0019130803,
-0.03442872,
0.017833002,
-0.009266168,
-0.017765759,
-0.009111507,
-0.007423693,
0.011579347,
0.00066823326,
0.016757105,
0.0097167,
0.01511636,
0.006263741,
-0.009891533,
0.020872412,
0.00020425243,
0.0022156765,
-0.0012826716,
0.020616887,
0.04494562,
-0.006899193,
-0.022284528,
0.043143492,
0.0020139457,
0.0020845514,
-0.007100924,
0.025902232,
0.02099345,
-0.0075783534,
0.018613027,
0.033433516,
-0.013811834,
0.02477254,
0.021504503,
0.016030874,
0.012177815,
0.009689802,
-0.0004622997,
-0.020939656,
-0.013105777,
0.006489007,
-0.02929131,
-0.036822595,
-0.010375687,
0.0021988656,
0.008371828,
0.016972283,
-0.00096578617,
-0.016420886,
-0.005658549,
0.03066308,
0.005796398,
-0.00812975,
0.00087248563,
0.03442872,
0.0044716992,
-0.0009430914,
0.00080187985,
0.0017483335,
0.013294059,
0.029963747,
0.03308385,
-0.014645655,
0.030797567,
0.00075060665,
0.010490001,
0.0014751564,
0.0017046252,
-0.0122181615,
-0.0168109,
-0.026588118,
0.0045221318,
0.022620745,
-0.020697579,
0.081714414,
0.0029536749,
-0.012090399,
0.008163372,
-0.023763888,
0.018505437,
0.022728335,
0.035154954,
-0.012379546,
-0.022203835,
0.020226873,
-0.015183604,
0.0075783534,
-0.032169335,
0.0046229973,
0.012177815,
-0.0267764,
0.02603672,
-0.004801193,
-0.009696526,
0.011929014,
-0.02068413,
0.0049760262,
0.020845514,
-0.0073698983,
-0.011229681,
0.024732195,
-0.0090442635,
-0.0017298415,
0.008802187,
-0.015869489,
0.028484387,
-0.046021517,
0.010416033,
-0.019648578,
0.0035706349,
-0.0047978307,
-0.034778386,
0.013784938,
0.026736055,
-0.016474681,
0.001869372,
-0.020764822,
-0.007880949,
-0.028054029,
0.004791106,
-0.00886943,
-0.013448719,
-0.025122207
] |
The amyloid cascade hypothesis posits that deposition of the amyloid β (Aβ) peptide in the brain is a key event in the initiation of Alzheimer's disease (AD). Nonetheless, it now seems increasingly unlikely that amyloid toxicity is the cause of sporadic AD, which leads to cognitive decline. Here, using accelerated-senescence nontransgenic OXYS rats, we confirmed that aggregation of Aβ is a later event in AD-like pathology. We showed that an age-dependent increase in the levels of Aβ₁₋₄₂ and extracellular Aβ deposits in the brain of OXYS rats occur later
|
[
-0.02483031,
-0.008968324,
0.011095512,
-0.022401115,
-0.031225001,
0.033614803,
0.00316616,
0.0014287933,
-0.03437639,
-0.002373389,
0.006430801,
-0.0066802856,
0.017030625,
0.018842673,
-0.00068690407,
-0.015454931,
0.03238051,
0.028073614,
-0.00025810194,
0.014601431,
-0.034428913,
0.009769303,
0.020720376,
-0.01376106,
0.015310492,
0.0009216168,
0.013196437,
-0.038026746,
-0.00938851,
-0.004119783,
0.01334744,
0.012329805,
-0.018067958,
-0.004887934,
0.029544262,
-0.0010086083,
0.0015477911,
0.013439356,
-0.0039392347,
-0.017752819,
0.010767242,
0.005468971,
-0.012060624,
-0.0015888247,
0.010465234,
0.0016766369,
-0.019866874,
-0.010780373,
-0.019079028,
0.01374793,
0.009683953,
0.01642661,
-0.008515312,
-0.008318351,
0.0025933296,
-0.01978809,
0.0061353585,
0.018041696,
0.003840754,
-0.0124742435,
0.01659731,
0.008252697,
-0.0159539,
0.00981526,
0.0019942375,
0.0116995275,
0.01830431,
0.0068477034,
-0.009802129,
0.014128722,
0.01961739,
0.015927639,
-0.02635348,
-0.017595248,
0.012553029,
0.0034172863,
-0.01659731,
-0.012776252,
-0.016282171,
0.016820533,
0.022348592,
-0.01826492,
-0.01408933,
0.02618278,
0.01274999,
0.006939619,
-0.02062846,
0.026865581,
-0.008869844,
0.0077405963,
0.014154984,
0.006483324,
0.0108132,
0.019013373,
0.012743425,
0.0011243232,
0.010826331,
0.027128197,
-0.018632581,
-0.03067351,
-0.008843582,
0.005081613,
-0.027417075,
-0.021363784,
-0.02548685,
-0.016058948,
-0.0023799543,
0.014864046,
0.016571049,
-0.016019555,
-0.0009511611,
0.031461354,
-0.006181316,
-0.03369359,
-0.008298655,
-0.006814876,
0.027049413,
0.005015959,
-0.009257202,
-0.023412187,
0.022729386,
0.02549998,
0.009178417,
-0.009152155,
-0.007248192,
0.021560745,
-0.0001874214,
0.0033302947,
0.009880914,
-0.009165286,
-0.0018186134,
0.011614177,
0.009697083,
0.0050061108,
-0.027443336,
0.001816972,
-0.017726557,
-0.009427902,
-0.006913357,
-0.03960244,
-0.0031349743,
0.022282938,
-0.035137974,
0.008272394,
0.0013081542,
0.053494807,
0.035768252,
0.015507454,
0.013032302,
0.004214981,
-0.013774191,
0.004096804,
-0.00021624757,
-0.012054059,
0.010944507,
0.017897258,
0.00014618254,
0.015310492,
-0.04511737,
-0.014627692,
0.024186902,
0.007957255,
-0.011463174,
0.010274838,
0.007011838,
0.01830431,
0.0010767241,
-0.016702356,
0.026786797,
-0.0372389,
-0.034796573,
0.001472289,
-0.018330572,
0.017726557,
0.0043331585,
-0.010721284,
0.01963052,
0.028546322,
-0.019577997,
-0.029596785,
-0.00667372,
-0.011266212,
0.023779847,
-0.014640823,
0.012027797,
-0.0041887197,
0.0143913375,
-0.012789383,
0.013734799,
-0.023543494,
-0.006384843,
0.010117268,
-0.007858774,
-0.043357845,
-0.63700056,
-0.038000487,
0.012421721,
-0.01123995,
0.006220708,
0.026103996,
0.005718456,
0.00061345374,
-0.016387217,
0.061819725,
-0.0037422732,
0.0432528,
0.008692578,
0.0012170594,
0.0036831845,
-0.01945982,
-0.008482486,
-0.008981455,
0.008298655,
0.019197205,
-0.023596017,
0.011463174,
-0.006099249,
-0.0005785751,
0.0076421155,
0.00039987336,
0.0052687265,
-0.022716254,
-0.013958022,
0.0523393,
0.0042313947,
0.010596542,
0.005774262,
-0.005610127,
0.051052485,
0.0052096383,
0.004910913,
0.013944891,
0.020877944,
0.03167145,
-0.0031119955,
-0.008686013,
-0.0021747858,
-0.013931761,
-0.012631813,
0.027627166,
-0.004346289,
0.0047402126,
0.0036437921,
-0.023425316,
0.0022749081,
0.0025539373,
-0.022913216,
-0.009290029,
0.017372025,
0.005449275,
0.023385923,
-0.022007192,
0.010990465,
-0.0070512304,
0.0031021475,
0.01910529,
-0.027574643,
-0.006043443,
-0.031146217,
0.0015280949,
-0.047717266,
0.007143146,
0.023228355,
-0.024081856,
0.016479133,
0.023202093,
-0.0071037533,
-0.00014546445,
0.023582885,
-0.0071497113,
0.018002303,
0.03287948,
-0.022571815,
0.003364763,
-0.011935881,
0.017253848,
-0.03437639,
0.0107869385,
0.0051308535,
0.00482228,
-0.019499213,
0.0069330535,
-0.0051833764,
-0.011502566,
0.012198498,
0.014798393,
-0.023622278,
-0.030988647,
-0.0019843895,
0.019394167,
0.005465688,
0.014667084,
0.02280817,
0.00045506368,
-0.032117896,
0.011246515,
-0.0025966123,
0.0048419763,
0.050632298,
0.017647771,
-0.017148802,
0.0001614676,
0.053941257,
-0.008712274,
-0.00023717477,
0.004510424,
0.004356137,
-0.011397519,
-0.015481193,
-0.024410125,
0.014273161,
-0.012638379,
0.006548978,
-0.03169771,
0.013163609,
-0.0023947265,
0.013498445,
-0.004300331,
0.004789453,
0.0069855764,
0.025211103,
-0.021061776,
-0.01928912,
-0.0052588787,
-0.013038867,
-0.028940246,
-0.0018350269,
-0.014365076,
0.009723345,
-0.0044710315,
0.018593188,
-0.013078259,
-0.0065949354,
-0.026366612,
-0.022860693,
0.0017956345,
-0.0035223325,
-0.010635934,
-0.018015433,
-0.00453012,
-0.02483031,
0.009585472,
-0.021271868,
0.0025539373,
-0.0014903438,
0.003440265,
-0.0039031252,
0.024134379,
-0.0040081716,
0.002071381,
0.00047475987,
-0.0020221407,
-0.0033056745,
-0.009486991,
-0.0041230656,
0.020470891,
-0.0036864672,
0.014732738,
-0.013143914,
-0.03419256,
-0.0013729875,
0.000100942896,
-0.016387217,
-0.021994062,
-0.0030545483,
-0.022886954,
-0.02936043,
0.010471799,
0.010819765,
0.034113772,
0.001519888,
-0.011272777,
0.015047877,
-0.017647771,
-0.0152579695,
-0.008206739,
0.0076880734,
0.011220254,
0.036319744,
0.009559209,
0.025447456,
0.0117454855,
0.0029101097,
0.030515939,
0.01678114,
0.06906792,
-0.0045563816,
-0.019499213,
-0.029911924,
-0.039313562,
0.017463941,
0.0021009252,
0.019696174,
0.013124217,
0.035768252,
-0.018724496,
0.032433033,
0.0032761304,
0.04207103,
-0.017214457,
0.00863349,
0.0060467254,
0.0132030025,
-0.003548594,
-0.015113531,
-0.0028920549,
-0.0002968788,
-0.025027271,
-0.0070906226,
0.024633348,
0.01762151,
-0.004119783,
-0.0017184912,
-0.026195912,
-0.012743425,
-0.008384005,
-0.003010232,
0.009506687,
-0.008311786,
0.027023152,
0.024672741,
0.014824654,
0.008429962,
-0.016978102,
0.005180094,
0.009086502,
0.0076421155,
0.025762595,
-0.0018465164,
0.0058628945,
-0.01809422,
0.014601431,
0.006220708,
0.010045049,
0.0046121874,
-0.0011587916,
0.0056823464,
0.015993293,
0.0025408065,
0.011108642,
0.03773787,
0.052523132,
0.0035288979,
0.006591653,
-0.00863349,
0.008193608,
-0.012598986,
0.008154216,
-0.007044665,
-0.009500122,
0.0045563816,
0.008377439,
0.02232233,
0.024593957,
0.023687933,
-0.00688053,
-0.005239182,
-0.0017660903,
-0.0081870435,
-0.01208032,
0.0023848785,
-0.0040081716,
0.015704416,
-0.0028657934,
-0.032774433,
-0.0073401076,
-0.015284231,
-0.029517999,
0.014916569,
0.015507454,
0.0009807054,
0.013399964,
0.020838553,
-0.004382399,
-0.031960327,
-0.031776495,
0.0034665267,
0.021823362,
-0.015363016,
-0.021285,
0.0005317967,
-0.017805342,
-0.0020040858,
0.0050651995,
-0.013071694,
0.010373319,
-0.019945659,
0.010649065,
-0.019814352,
-0.0010914963,
0.026773667,
-0.0060565737,
0.010268272,
-0.028651368,
-0.00586946,
0.0034927882,
0.0077077695,
-0.014023676,
0.031986587,
0.0017972759,
-0.008252697,
0.017976042,
-0.000376279,
-0.006667155,
0.007911297,
-0.012848471,
-0.0151660545,
0.028913984,
-0.011673266,
0.011863662,
-0.010491495,
0.0032121178,
0.028467538,
0.0115616545,
0.007333542,
-0.010937942,
-0.014719607,
-0.0025539373,
0.03403499,
0.027443336,
-0.025408065,
0.0012039286,
0.014220638,
0.01661044,
-0.0013171816,
-0.023766717,
0.028598845,
0.017595248,
-0.029938186,
-0.011299038,
0.039050948,
-0.006325755,
0.018580059,
0.03555816,
-0.0030742446,
-0.025854511,
0.02115369,
-0.01190962,
0.011870228,
-0.013301483,
0.022913216,
0.018396227,
0.0011054478,
-0.016649833,
-0.008206739,
0.018396227,
0.009651125,
-0.030647246,
-0.01709628,
0.01661044,
-0.0041460446,
0.013498445,
0.011344996,
0.0008863278,
-0.0061222273,
0.0067492225,
-0.001273686,
-0.0023208659,
0.013183306,
-0.014102461,
0.020050704,
0.0019269424,
0.006512868,
0.004425074,
0.014273161,
-0.0040836735,
-0.006407822,
-0.016754879,
0.011706093,
-0.005692194,
-0.017752819,
-0.0046450146,
0.014601431,
-0.025027271,
0.022243546,
-0.02802109,
0.02045776,
-0.014207507,
-0.017818471,
-0.005298271,
0.004812432,
-0.016886186,
0.0056363884,
-0.031776495,
-0.004562947,
0.015625631,
-0.006913357,
-0.012914125,
0.004628601,
-0.0035847037,
-0.03182902,
0.0062732315,
0.007911297,
0.031277526,
0.009670822,
-0.04422448,
0.010780373,
0.015034746,
-0.022335462,
0.010353622,
-0.019643651,
-0.017004363,
0.010780373,
-0.009106198,
0.016715486,
-0.037002545,
0.006020464,
0.016702356,
0.017372025,
-0.023359662,
0.026813058,
0.0045892084,
-0.004812432,
-0.02263747,
0.022361724,
0.03957618,
-0.015034746,
-0.01729324,
-0.0010841102,
-0.006611349,
-0.018698234,
-0.031172479,
-0.0046975375,
-0.012887863,
0.0070052724,
-0.006946184,
0.0028149115,
-0.013124217,
0.0011103718,
-0.0084168315,
0.011377824,
0.009368814,
0.0135247065,
0.010025352,
0.004812432,
0.018238658,
-0.004142762,
0.011010162,
0.008640056,
-0.00278865,
0.0322492,
-0.0116995275,
-0.018501272,
0.016374087,
0.0067820493,
-0.020549675,
-0.020838553,
-0.014063069,
0.006506303,
0.03702881,
0.011364693,
-0.0382631,
-0.037869178,
-0.006699982,
-0.00729415,
-0.017687164,
0.00035781384,
-0.0026852451,
-0.011141469,
-0.00029523743,
-0.024252556,
0.005774262,
0.031645186,
-0.03676619,
-0.013111087,
0.0049700015,
0.01743768,
0.0057808273,
-0.025014142,
-0.013216133,
-0.03403499,
-0.010465234,
-0.0023290727,
-0.0011957219,
0.0064340835,
-0.002406216,
0.051393885,
0.019551735,
0.033746112,
0.0040803906,
0.015546847,
0.019683043,
0.021941539,
-0.005879308,
-0.00014156626,
0.015559978,
-0.0063782777,
0.020575937,
-0.0080951275,
0.0052260514,
0.030804817,
-0.041073088,
0.023622278,
0.016964972,
0.015021616,
-0.031855278,
-0.0036405094,
-0.04262252,
-0.031934064,
0.009756172,
0.009775868,
0.014969093,
-0.0422286,
-0.0039195386,
0.012855036,
0.030936124,
0.008272394,
-0.030515939,
0.03287948,
-0.016846795,
0.0017956345,
0.014890308,
-0.014312553,
0.001125144,
-0.038026746,
0.030305848,
-0.001500192,
0.023385923,
-0.021994062,
-0.006525999,
0.013550968,
-0.006030312,
0.0010307664,
0.01057028,
-0.03377237,
0.009598603,
-0.015205447,
-0.02447578,
-0.019919397,
-0.026248435,
-0.012966648,
-0.032564342,
0.009447598,
0.02079916,
-0.009749606,
0.021009253,
-0.015087269,
-0.01978809,
0.0078916,
-0.0022043302,
0.011607612,
-0.01877702,
0.011502566,
0.014168114,
-0.0054427097,
-0.02430508,
0.0038440367,
0.011870228,
0.0162953,
0.041046828,
0.02631409,
-0.03487536,
0.012598986,
-0.016557917,
0.008994586,
-0.028441276,
-0.025959557,
0.03406125,
0.021600138,
-0.0014156625,
0.0036766191,
-0.026589835,
-0.002312659,
-0.0014501308,
-0.022834431,
-0.036424793,
0.00072957913,
-0.021573877,
-0.005629823,
0.0038867118,
0.0037422732,
0.011450043,
-0.012874733,
-0.023254616,
-0.006115662,
-0.015980164,
-0.0034763748,
0.002458739,
0.015861986,
0.03474405,
-0.019774958,
0.021390045,
0.0065227165,
0.020680983,
-0.003591269,
-0.0047434955,
-0.012100017,
0.038683288,
-0.015152924,
-0.004812432,
0.0142994225,
0.011962143,
0.0013852976,
-0.013163609,
0.008777929,
-0.022519292,
-0.020470891,
-0.0024275535,
0.024974748,
0.0010127117,
-0.009940003,
0.010997031,
-0.014706477,
0.013669145,
-0.019761829,
-0.029964447,
0.005770979,
-0.029255385,
-0.0034008727,
0.00016218568,
0.031461354,
0.009723345,
-0.00226506,
0.0029593501,
-0.011811139,
0.009841521,
-0.023399055,
0.012421721,
0.0152579695,
0.006667155,
-0.016479133,
0.009716779,
-0.01861945,
0.017910387,
0.012946952,
-0.01729324,
-0.040127672,
0.0017939932,
0.0022240262,
0.014168114,
0.020011313,
-0.023307139,
0.01691245,
-0.01745081,
0.0108132,
0.015888248,
-0.02870389,
0.006079552,
-0.009611733,
0.023097048,
-0.0014845991,
-0.006913357,
-0.013944891,
0.016531656,
-0.0151660545,
0.005793958,
-0.016991233,
-0.0115156965,
0.0045596645,
0.01928912,
-0.022177892,
-0.011614177,
0.003538746,
-0.02483031,
-0.011364693,
0.0027755192,
-0.008101693,
-0.0014263312,
-0.03490162,
0.0037160115,
-0.016203387,
-0.008587532,
-0.0071168845,
0.0007139863,
0.018107349,
-0.020720376,
-0.02988566,
-0.015126661,
-0.017660903,
0.019262858,
0.021219345,
0.004411943,
0.0060106157,
-0.009362248,
-0.017516464,
0.0010299458,
-0.010406146,
-0.0021353934,
0.021088038,
0.020116359,
0.013459052,
0.024147509,
0.028073614,
0.014076199,
-0.007760293,
-0.014837785,
0.0143913375,
-0.030594723,
-0.007346673,
0.0066277627,
-0.007714335,
0.00423796,
0.038236838,
-0.012690902,
-0.019774958,
0.028572584,
0.013229264,
0.019643651,
-0.033037048,
0.0046318835,
0.007930993,
-0.010589977,
0.015730677,
-0.014128722,
0.0027722365,
0.0023684648,
-0.0083249165,
-0.0013089749,
-0.011496,
-0.0020845118,
-0.0041591753,
-0.01542867,
-0.0057972404,
-0.009795564,
0.0036930328,
-0.010268272,
0.017634641,
0.028861461,
0.0027755192,
0.0019433559,
0.021613268,
-0.00813452,
-0.012618682,
-0.008029474,
0.00043823986,
-0.018146742,
0.008239566,
-0.012145974,
0.009506687,
-0.0058235023,
0.011003596,
-0.040180195,
0.0062732315,
-0.0106425,
-0.016216516,
-0.030620985,
0.026222173,
0.002099284,
-0.014063069,
-0.0041788714,
0.007970385,
-0.016452871,
-0.0073860656,
-0.0035551596,
0.0034566785,
-0.0076683774,
-0.013354006,
0.015468062,
-0.0016741748,
-0.00871884,
-0.0127040325,
-0.012257585,
-0.022598077,
0.0013459052,
0.18561675,
-0.031487618,
0.0043659853,
0.0019548454,
-0.008246131,
-0.018842673,
0.003327012,
0.0034665267,
-0.00019049893,
0.0152579695,
0.032669388,
0.022007192,
-0.01055715,
0.0074385884,
-0.017148802,
-0.0066638724,
-0.021757707,
0.0016052382,
-0.0063717123,
-0.011784878,
0.018987112,
-0.008252697,
-0.0029199577,
-0.0031825735,
0.040862996,
0.00066679757,
-0.0012203421,
-0.020746637,
0.012106582,
0.018698234,
-0.006243687,
-0.0044940105,
-0.003274489,
0.022571815,
-0.02045776,
-0.011843966,
-0.03340471,
-0.006483324,
0.0068542687,
0.007471415,
0.019499213,
0.028598845,
-0.008042605,
0.009290029,
-0.013051998,
0.007077492,
0.01282221,
-0.020352714,
-0.0051275706,
0.007911297,
-0.035847038,
0.009854653,
-0.015546847,
0.00015397895,
0.020510282,
-0.009670822,
-0.00085842493,
0.032774433,
-0.01225102,
0.02699689,
-0.028231183,
0.002260136,
-0.027101936,
0.019643651,
-0.015993293,
0.022965739,
-0.0011555089,
-0.016505394,
0.0051866593,
0.0013680634,
0.0150741385,
-0.02346471,
-0.017306373,
-0.006404539,
-0.002580199,
-0.013879238,
0.04797988,
0.027259504,
0.020733505,
0.0026294393,
0.00864662,
0.023609148,
-0.029229123,
-0.0011456608,
-0.015822593,
-0.036030866,
0.02096986,
0.005751283,
-0.013137348,
-0.0041690236,
-0.000048265887,
-0.015507454,
-0.008882974,
0.003450113,
0.011299038,
-0.007871904,
0.014430731,
0.009211244,
-0.0059810714,
0.002745975,
-0.038158055,
0.068227544,
0.0028493798,
0.034087513,
-0.019472951,
0.0039195386,
-0.016859924,
0.023490971,
0.008640056,
0.0060237464,
-0.024882833,
-0.018251788,
-0.003450113,
-0.022584947,
-0.017857864,
0.037133854,
0.013550968,
-0.0032121178,
0.031277526,
-0.020536544,
-0.0110167265,
-0.039497394,
-0.014049938,
0.014772131,
0.008357743,
-0.0063914084,
-0.016649833,
0.003274489,
-0.0044185086,
-0.034350127,
0.0024554564,
0.0022470052,
-0.006079552,
-0.007714335,
-0.013629752,
-0.002076305,
0.0019811068,
-0.0020516848,
0.010517757,
0.030594723,
-0.024580825,
-0.025880773,
0.028336229,
-0.0018596471,
0.008640056,
0.00043700886,
0.0110626845,
0.0022043302,
-0.022886954,
-0.008600662,
-0.022256676,
-0.02802109,
-0.00746485,
-0.014036807,
0.005547756,
-0.026419135,
-0.012159104,
-0.050422207,
-0.030726032,
0.019210335,
-0.023490971,
0.027574643,
0.010819765,
-0.0117454855,
0.010517757,
-0.01577007,
-0.16366208,
-0.005124288,
0.002957709,
-0.03201285,
-0.00059539895,
-0.007760293,
0.018107349,
-0.0012441417,
0.010261707,
-0.012191932,
0.025788857,
-0.028073614,
-0.028782675,
0.01827805,
0.019551735,
-0.0021107732,
0.013314614,
0.016282171,
0.013393398,
0.00081574987,
-0.0015962108,
-0.03742273,
0.026799928,
-0.0005227693,
0.006775484,
-0.0004023354,
-0.0055707344,
-0.0037455559,
-0.009953134,
-0.011587916,
-0.006204295,
-0.013019172,
0.034639005,
0.003788231,
0.01374793,
-0.0020582501,
-0.0211143,
-0.026813058,
-0.0078916,
0.0045760777,
0.036135916,
0.060769264,
0.0031382572,
0.0005141522,
-0.0116995275,
0.043068968,
0.012953517,
-0.009848087,
0.01843562,
0.019039635,
0.019669913,
-0.011509131,
-0.0026967346,
0.029833138,
-0.0039556483,
-0.001500192,
0.012257585,
0.016282171,
0.0025457304,
-0.005629823,
-0.010005657,
-0.026077734,
0.028336229,
0.011706093,
-0.009926871,
-0.024895964,
0.0029544262,
0.0029806877,
-0.03140883,
0.00045342234,
0.002580199,
-0.018566927,
0.016518524,
-0.019499213,
0.0029412953,
0.03902469,
-0.009329421,
0.004077108,
-0.00046203943,
0.01106925,
-0.005019242,
0.006729526,
-0.039050948,
-0.0150741385,
-0.018816411,
-0.015389278,
0.019696174,
0.0102420105,
-0.009171852,
-0.027023152,
0.0033581976,
-0.016728617,
0.012815644,
-0.021245606,
-0.0061714677,
0.026156519,
-0.0144832535,
0.005180094,
0.009880914,
-0.0036634884,
0.015848855,
0.002783726,
-0.023136439,
0.013656015,
0.028598845,
-0.0011292474,
-0.019893136,
0.0047599087,
0.03458648,
-0.018698234,
0.0081410855,
0.010826331,
0.010931376,
0.023097048,
-0.024410125,
0.022440508,
0.006860834,
-0.005298271,
0.016505394,
-0.010478364,
0.073847525,
-0.004119783,
-0.0019318664,
0.0073860656,
-0.013183306,
-0.015139792,
-0.13298857,
-0.019853743,
-0.013354006,
0.028913984,
0.010412711,
-0.013485314,
0.011292473,
0.060979355,
-0.018658843,
0.01931538,
-0.011633874,
0.0071497113,
-0.0013352365,
-0.010452103,
0.009861218,
-0.0059383963,
0.020221405,
0.018829543,
-0.033588544,
0.032117896,
-0.014273161,
-0.0036930328,
0.028651368,
-0.015494323,
0.0032859785,
0.01106925,
-0.02433134,
0.019472951,
-0.0100122215,
0.018501272,
0.027548382,
-0.015008485,
-0.008206739,
0.00094213366,
0.0071365805,
-0.027863521,
0.004172306,
0.000356788,
0.045222417,
-0.0024423257,
-0.0015510737,
0.0013130783,
0.03335219,
0.027390813,
-0.010136965,
-0.0149822235,
-0.016715486,
-0.007701204,
0.008456225,
-0.021285,
-0.0012909201,
-0.019696174,
-0.0018186134,
-0.020917337,
0.01827805,
-0.004086956,
0.010708153,
0.03406125,
-0.016584178,
-0.015034746,
-0.00019809017,
-0.004756626,
-0.016137732,
-0.0080951275,
0.03739647,
-0.015454931,
-0.036792453,
-0.024620218,
0.0007673301,
-0.029570524,
0.012999475,
-0.013360571,
-0.008948629,
0.000014336148,
-0.020707244,
0.0062601008,
-0.0015715905,
-0.017070018,
0.013472184,
-0.0100122215,
-0.014404469,
-0.0014328967,
0.013774191,
-0.019683043,
0.01777908,
0.006263383,
0.009697083,
0.01007131,
0.01031423,
-0.015231708,
-0.006591653,
0.027469598,
-0.012940386,
0.0004977387,
-0.004142762,
0.0010701588,
-0.017884126,
-0.032616865,
0.039996363,
0.017490203,
-0.01963052,
-0.028415013,
-0.029517999,
0.014181245,
0.005748,
-0.0031546706,
-0.0054066,
0.009894045,
0.0073860656,
-0.023517232,
-0.02132439,
0.018015433,
-0.0002492797,
0.007917862,
-0.011804574,
0.008587532,
-0.013216133,
-0.017372025,
0.051919114,
-0.005790675,
0.029728092,
0.030279584,
-0.0031825735,
0.02731203,
-0.000076579134,
0.018895196,
-0.020484021,
-0.01266464,
-0.00763555,
0.020365844,
-0.0020451194,
0.008843582,
0.00964456,
-0.044670925,
0.019249728,
-0.000831753,
0.0034927882,
-0.009828391,
0.018081088,
0.016676094,
0.03287948,
0.04430326,
-0.0075042425,
-0.03217042,
0.008167347,
-0.036582362,
-0.019328512,
0.0026310806,
-0.04010141,
-0.0035978344,
0.017358895,
-0.016728617,
0.025893904,
0.017227586,
0.0106031075,
-0.021429438,
-0.02582825,
0.0219678,
0.022742515,
0.0032580756,
-0.028913984,
-0.028730152,
0.0053672073,
0.006447214,
-0.005255596,
0.021285,
0.010629369,
-0.00482228,
-0.015559978,
0.00061755715,
0.011377824,
-0.007471415,
0.0011669983,
-0.0019663346,
0.011141469,
0.009224375,
-0.017923519,
-0.0019548454,
-0.03335219,
-0.012861602,
-0.014036807,
0.0043758336,
-0.010281403,
-0.0084627895,
-0.023727324,
0.00906024,
0.025841381,
-0.007313846,
0.0048813685,
0.01843562,
-0.00071973103,
0.0011341714,
0.009972829,
0.017910387,
0.0046351664,
0.007852208,
0.019381035,
0.005255596,
-0.011916186,
-0.0002226078,
-0.0050651995,
0.01930225,
-0.0058858735,
-0.0036011173,
-0.02752212,
-0.014233769,
-0.026602967,
0.0073401076,
-0.026419135,
-0.026773667,
0.004382399,
0.0026130257,
0.016571049,
0.009073371,
0.0034107207,
0.0013286711,
-0.017083148,
0.01726698,
0.0005995023,
-0.0056560845,
-0.0004008992,
0.018291181,
0.006873965,
-0.002547372,
-0.0106950225,
0.009316291,
0.0080951275,
0.0021337522,
0.029229123,
-0.03524302,
0.008311786,
-0.020851683,
0.021206215,
-0.03991758,
-0.029491737,
0.005157115,
-0.011765181,
-0.035190497,
-0.00041361965,
0.04259626,
-0.0054525575,
0.07421518,
0.019065896,
-0.0019564866,
0.00083872874,
-0.0068673994,
0.016925579,
-0.0030118732,
0.023372794,
-0.0014903438,
-0.027758475,
0.0115156965,
-0.030909862,
0.026156519,
-0.041204397,
-0.033115834,
0.016190255,
0.003788231,
0.02012949,
0.0010004016,
-0.045432508,
0.038446933,
-0.01830431,
0.01676801,
-0.0012613758,
-0.012500505,
0.02181023,
0.047244556,
-0.022256676,
-0.0057348693,
-0.022401115,
-0.025815118,
0.0027147892,
-0.020680983,
-0.0073729344,
0.011443477,
-0.016964972,
0.00051579357,
-0.0061747506,
0.003988475,
-0.0069067916,
-0.0050061108,
-0.009933437,
-0.01843562,
-0.025854511,
-0.0057808273,
0.00507833,
-0.033142097,
-0.01978809,
-0.0065653916
] |
We compared low-density lipoprotein cholesterol (LDL) values obtained by the Friedewald formula--i.e., total cholesterol minus high-density lipoprotein (HDL) cholesterol minus very-low-density lipoprotein (VLDL) cholesterol (estimated as triglyceride divided by 5)--with those obtained by lipoprotein fractionation, using 4736 specimens. When triglycerides were less than 2.0 g/L, greater than 90% of estimated LDL cholesterol values were acceptable, within +/- 10% of measured values. At triglyceride concentrations of 2.0-4.0 g
|
[
-0.016806312,
0.014584638,
0.016767107,
-0.035180867,
-0.00831821,
-0.0015012637,
-0.025170263,
-0.0052209347,
-0.026424855,
-0.012683147,
0.0015698742,
0.04202885,
-0.020060413,
-0.0005064111,
-0.0083378125,
0.03614795,
0.023667365,
-0.02037406,
0.031730738,
0.0013256534,
-0.012121193,
0.0072073727,
-0.01014129,
-0.0062108864,
-0.0107555175,
-0.004319196,
0.020321785,
-0.020936012,
-0.01683245,
-0.018452965,
0.036383186,
0.0011083868,
-0.03957194,
0.020739984,
-0.0053385524,
-0.004874615,
-0.007638639,
0.0020713846,
0.03277623,
-0.00401535,
0.011650722,
0.004609974,
0.003216527,
0.02117125,
0.004312662,
-0.009396375,
0.008403156,
0.00039655252,
-0.024451487,
0.03769005,
0.006161879,
0.011578844,
0.013232031,
-0.033900134,
-0.013264703,
0.019459253,
0.0061847493,
0.0057567502,
-0.0020534152,
-0.0061978176,
-0.029195413,
-0.023157688,
-0.0080307,
-0.023079276,
-0.0135260755,
0.00016866755,
0.009625077,
0.036932066,
0.004276723,
0.03217507,
0.0031070767,
0.0074164714,
-0.005521514,
0.018165454,
0.040486746,
0.00012486707,
-0.022974726,
-0.010330785,
-0.005080446,
-0.020909876,
0.01634891,
0.0067172977,
-0.00807644,
0.020125756,
0.018884232,
-0.009304895,
0.009043521,
0.031051164,
-0.0043812725,
-0.015055111,
0.0075732954,
0.011722599,
0.010958082,
-0.015329553,
-0.00084619655,
-0.021079767,
-0.0021906362,
0.0069459993,
0.0033945877,
-0.019720627,
-0.007599433,
-0.0020174764,
-0.010089015,
-0.0082071265,
-0.02599359,
-0.011291333,
0.00031017678,
-0.011382814,
-0.019459253,
0.0033978547,
-0.011127975,
0.027496487,
0.020347923,
-0.024556035,
0.018479103,
-0.008069905,
0.01800863,
0.016375046,
-0.012441376,
-0.0038193194,
0.01644039,
0.005812292,
0.04310048,
-0.008174455,
-0.005184996,
0.012892245,
0.0022363765,
-0.014231784,
-0.0033047404,
0.024333868,
0.018060906,
0.00684145,
0.0002139995,
0.004159105,
-0.027182838,
-0.008233263,
-0.007128961,
0.01339539,
-0.009363703,
-0.0025434904,
0.0014424548,
0.022465048,
0.0044041425,
-0.0020844531,
0.003502404,
0.03248872,
0.023353718,
0.021863889,
-0.018400691,
-0.028960178,
-0.013114412,
0.0023964678,
0.049347308,
0.009050055,
-0.0010373258,
0.023262236,
0.0143755395,
0.0047145234,
-0.025980521,
0.022700284,
-0.018270005,
-0.012905314,
0.011899026,
0.014453951,
0.036749106,
0.0072465786,
0.015002836,
-0.007155098,
-0.0070244116,
0.0060017877,
-0.009945259,
0.042499322,
-0.027182838,
0.019341635,
0.006246825,
0.017930219,
0.011533103,
-0.010356923,
-0.017407471,
-0.027810134,
-0.015081248,
0.042290222,
0.031443227,
-0.011983972,
-0.013362718,
0.008089508,
0.029090865,
0.004322463,
0.019916657,
-0.035024043,
-0.009376773,
0.0025189866,
-0.0057175444,
-0.034344472,
-0.6502971,
-0.034213785,
0.015015905,
0.0024030022,
0.0080307,
0.012781162,
0.022556528,
0.009095796,
-0.024229318,
0.012323758,
0.0121604,
0.02313155,
-0.0064820615,
-0.01870127,
0.0025990321,
-0.03476267,
-0.02314462,
0.012199606,
-0.0040512886,
-0.016780175,
-0.037533227,
-0.0026464062,
-0.009566268,
-0.0038323882,
0.01742054,
0.015904574,
0.015055111,
-0.011801011,
-0.012683147,
0.009141536,
0.012186537,
-0.006821847,
-0.00037449913,
0.029012453,
0.04085267,
-0.02441228,
0.010180496,
0.013088276,
0.028724942,
0.01515966,
-0.019812107,
-0.007253113,
0.027444212,
0.013114412,
-0.012349895,
0.024556035,
-0.004917088,
0.029613612,
0.004472753,
0.014231784,
-0.0010601961,
-0.010846998,
-0.01919788,
-0.0065996796,
0.009174208,
-0.025170263,
0.0188973,
-0.024294661,
0.0009736161,
0.00023298993,
-0.005616262,
-0.028045371,
-0.007155098,
0.017342128,
-0.022321293,
0.0020289114,
0.0042342497,
0.0071616326,
0.029587474,
-0.003090741,
-0.008403156,
0.03081593,
0.004802737,
-0.009246086,
0.024556035,
0.0016188818,
0.035938848,
-0.0038029836,
0.007266182,
0.006723832,
0.0377946,
0.013865861,
0.022491185,
-0.0015657903,
-0.019694488,
0.018256934,
0.0058449637,
0.025745284,
0.009069659,
0.010056343,
0.019982,
0.017407471,
0.012768093,
-0.03643546,
-0.01723758,
0.032671683,
-0.021288868,
-0.010735914,
0.009755764,
-0.007619036,
-0.017956356,
-0.00030854318,
0.002100789,
0.0039173346,
0.03031932,
-0.00019745946,
-0.012108125,
0.0018361484,
0.013735174,
-0.045322154,
-0.0066617555,
0.0032410307,
-0.014323265,
-0.0127223525,
0.0020289114,
-0.01515966,
-0.013591419,
0.00040512884,
-0.012800764,
-0.052692886,
0.007285785,
0.008403156,
0.018256934,
0.0077693257,
-0.013055604,
0.012284552,
0.005524781,
0.00080045615,
-0.00871027,
-0.015917642,
-0.0051817284,
0.04636765,
0.01999507,
-0.018531376,
0.0035089385,
0.018073974,
0.0077889287,
0.0023180558,
-0.009089261,
-0.05541117,
0.000879685,
-0.0044041425,
0.010840463,
-0.022282086,
0.005789422,
-0.022360498,
0.03748095,
0.015525582,
0.010481075,
0.021772409,
-0.01772112,
-0.022621872,
-0.013310443,
0.00015621148,
-0.0033227098,
-0.006240291,
0.00553785,
-0.030528419,
0.025653804,
0.005051042,
-0.0076647764,
-0.002469979,
0.0049856985,
0.010343854,
0.021380348,
-0.014414745,
0.009585871,
0.00066323514,
-0.013349649,
-0.01612674,
-0.00757983,
-0.029587474,
-0.009808038,
0.01457157,
-0.010742448,
0.030763654,
-0.005795956,
-0.0042603873,
0.0048713475,
-0.017747257,
0.019916657,
-0.0143755395,
-0.0031936567,
0.023092344,
0.040512886,
0.0017217976,
0.011539638,
-0.0018149118,
-0.009513994,
-0.0003295756,
-0.0080307,
0.008082974,
0.0037017015,
-0.018034767,
0.0017446678,
0.012905314,
0.017773394,
-0.01654494,
0.0201911,
0.010801258,
0.03612181,
-0.0073641967,
0.020125756,
-0.021772409,
0.0334558,
-0.024752066,
0.00038307544,
-0.004299593,
0.002509185,
0.02283097,
0.005871101,
0.0021318272,
-0.010631365,
-0.0043486007,
-0.019511528,
0.010598693,
0.012918383,
-0.0124087045,
0.010840463,
-0.01485908,
0.015512514,
-0.0025598262,
0.011931698,
0.00033284276,
-0.009932191,
-0.016192084,
0.024647515,
0.004123166,
-0.01255246,
-0.014584638,
-0.0029126804,
-0.03337739,
0.0058743684,
0.010468006,
0.008945506,
0.021733202,
0.013931205,
-0.0082071265,
0.016453458,
0.003907533,
-0.0042146468,
0.017302923,
0.024229318,
-0.008742942,
-0.00031078936,
-0.016701763,
0.011702996,
0.02854198,
-0.0036657625,
0.0022641474,
0.020831464,
0.013049069,
-0.016270498,
0.009487856,
-0.010030206,
-0.007011343,
0.011258661,
0.0039565405,
0.013408458,
0.027705586,
0.021929232,
0.007677845,
0.0025467575,
-0.01742054,
0.019942794,
0.0017659044,
-0.008893232,
-0.008252867,
-0.0027280853,
-0.001311768,
-0.013513007,
0.004031685,
0.00081801723,
-0.037951425,
0.010160892,
0.0025794292,
0.03431833,
-0.011284798,
0.026398718,
-0.00082291797,
-0.03238417,
-0.008233263,
0.022961657,
0.029953398,
-0.0060148565,
-0.021929232,
-0.010317717,
-0.008880163,
0.008050302,
0.011899026,
0.00807644,
-0.009808038,
0.036409322,
-0.0005223385,
-0.03217507,
-0.017498951,
0.013918136,
-0.015904574,
0.0020044076,
-0.00536469,
0.0036396252,
0.0028571384,
-0.006086734,
-0.013774381,
0.019210948,
0.00371477,
-0.002662742,
0.026738504,
0.01485908,
0.0045511653,
0.008239798,
-0.0039500063,
0.0051751942,
0.017315991,
0.005381026,
0.0015110653,
-0.024111701,
0.014453951,
0.021001356,
0.00029996686,
-0.003185489,
-0.017825669,
-0.025614597,
-0.012212674,
0.02587597,
0.011193317,
0.011957835,
0.001994606,
-0.0020566822,
0.015015905,
-0.00974923,
-0.009566268,
0.020256443,
0.034814943,
0.020164961,
-0.027026014,
0.012134262,
0.0021857354,
-0.0068153124,
0.0008437462,
-0.009945259,
-0.012761558,
0.0129902605,
0.0025990321,
-0.005534583,
0.00035019958,
0.015290347,
0.036069535,
0.0015772254,
0.01496363,
0.008762545,
0.019982,
0.00032937137,
0.01704155,
-0.01612674,
0.015434102,
-0.010539884,
0.004335532,
-0.010004069,
0.0036690298,
0.002540223,
-0.027914684,
0.0054921093,
0.008011096,
0.010964616,
0.02254346,
-0.0065768096,
0.026816916,
0.007468746,
-0.0072335103,
-0.013852793,
0.030476144,
0.028385157,
-0.0142840585,
0.028568117,
0.010193564,
-0.009108865,
0.006145543,
-0.018400691,
-0.04459031,
0.0021383616,
-0.03110344,
-0.008671064,
-0.0191064,
0.008657996,
-0.022687215,
0.03612181,
-0.011931698,
-0.0011500432,
0.008736407,
-0.008762545,
-0.012905314,
-0.022386635,
-0.004704722,
-0.014192578,
-0.014244853,
-0.011892492,
-0.00871027,
-0.02263494,
-0.004727592,
-0.0002983333,
-0.013284305,
0.009102331,
0.013316977,
-0.024281593,
0.012310689,
0.009853779,
-0.019328566,
-0.0036036863,
0.002089354,
0.0038552582,
-0.006828381,
-0.010200099,
-0.028123783,
-0.0040545557,
0.0035840834,
0.01485908,
-0.0035089385,
-0.015342621,
-0.012715818,
0.015290347,
-0.004783134,
0.017498951,
-0.006586611,
-0.01185982,
0.0021465295,
0.013669832,
-0.023784984,
-0.0008911201,
0.008540377,
-0.009481322,
-0.013434595,
0.027026014,
-0.019799039,
-0.0017250647,
-0.0057828873,
0.00043371657,
0.0030940082,
0.023798052,
0.026333375,
0.0054169646,
0.011180249,
0.0030858403,
-0.009716558,
-0.009161139,
-0.0032655345,
0.011983972,
-0.015486376,
-0.018583652,
0.022190606,
-0.0003900182,
-0.02343213,
-0.017995562,
-0.0016760572,
0.02117125,
0.008475034,
-0.0025712613,
0.0014261189,
-0.029639749,
-0.015290347,
0.0044400813,
-0.010415732,
-0.028934041,
0.00054970104,
0.0057404144,
0.011761805,
-0.025248675,
-0.022883246,
0.016192084,
-0.025157195,
-0.007965356,
0.0016923931,
-0.027444212,
0.021615583,
0.016270498,
-0.0066029467,
-0.065291084,
-0.011428554,
-0.003216527,
0.0028636728,
-0.01859672,
0.005965849,
0.023419062,
0.022961657,
0.033220567,
0.00049783476,
-0.008932438,
-0.0076517076,
-0.00077391043,
0.011591912,
-0.0019554,
0.017211441,
-0.024843546,
0.007939219,
0.023941807,
-0.008501171,
-0.0013950808,
-0.010102084,
0.012591666,
0.011742202,
0.011173715,
-0.004273456,
0.00066119316,
-0.018087042,
0.011546172,
-0.016936999,
0.014022686,
0.017485883,
-0.013081741,
-0.03384786,
0.0155386515,
-0.0042473185,
0.01279423,
-0.013539145,
0.02421625,
-0.040329922,
0.012003575,
0.015734682,
-0.0078216,
-0.0045380965,
-0.03999014,
-0.0057665515,
0.0030286647,
0.022229811,
-0.0075079524,
0.010180496,
0.004783134,
-0.008475034,
-0.021733202,
-0.008847491,
-0.018714339,
0.0021383616,
-0.0018818888,
-0.01841376,
0.0030172297,
-0.0104418695,
-0.0221514,
-0.025941314,
-0.017982492,
0.021445692,
-0.009631611,
0.004315929,
-0.011801011,
-0.011676859,
0.00516866,
0.008448897,
0.029744297,
-0.030763654,
0.040539023,
0.0061553447,
0.010860067,
-0.028280606,
0.0060540624,
0.00058563985,
0.008187523,
0.038448036,
0.026254963,
-0.026137345,
0.012055851,
-0.025562324,
0.02814992,
-0.012415239,
-0.03672297,
0.02156331,
0.00275749,
-0.011997041,
0.006455924,
0.008475034,
-0.05209173,
0.012349895,
0.005675071,
-0.01249365,
-0.006139009,
-0.0017234312,
-0.024268525,
0.04330958,
0.00017673337,
0.006593145,
-0.017930219,
0.008631858,
-0.002576162,
-0.03701048,
-0.031861424,
0.017185304,
0.034971766,
0.012624337,
-0.0034272594,
-0.023902602,
0.005482308,
0.02371964,
0.0027819937,
0.0059397114,
-0.02243891,
0.031547774,
-0.0078019975,
0.0021955369,
0.038526446,
-0.014205647,
0.0054136976,
0.01407496,
-0.0070440145,
-0.009834176,
-0.049242757,
0.0035318087,
0.021785477,
-0.014976699,
-0.03839576,
-0.008409691,
-0.01131747,
-0.007272716,
-0.032462582,
-0.03580816,
0.050183702,
-0.034788806,
-0.0035938849,
-0.0054398347,
-0.0023932005,
0.010448404,
0.0026415053,
-0.0012137529,
-0.01939391,
0.04477327,
-0.04163679,
0.054888424,
0.0051229196,
0.025941314,
-0.043570954,
0.005201332,
-0.021497967,
-0.029482925,
0.0036657625,
-0.0060769324,
-0.025849834,
-0.03580816,
0.0015992788,
-0.0018949575,
-0.000118843236,
-0.0054888423,
0.016806312,
-0.011448157,
-0.0012456079,
-0.009180742,
-0.006429787,
0.031730738,
-0.019720627,
0.00757983,
0.010330785,
0.015015905,
0.025065713,
0.0032426643,
-0.004146036,
0.020243373,
0.017603502,
0.0051425225,
0.0048452104,
0.017067686,
-0.03748095,
-0.0027313526,
-0.015434102,
0.0038748614,
-0.007311922,
0.0010242572,
0.014218715,
-0.024438417,
-0.0055280486,
-0.015434102,
-0.021288868,
-0.0076451735,
0.007403403,
-0.021785477,
0.0020338122,
0.0000971472,
-0.008880163,
0.0030760388,
-0.006985205,
0.028777216,
0.021680927,
-0.019171743,
0.0057077426,
0.003275336,
-0.031443227,
-0.024647515,
-0.037062753,
0.020609297,
-0.022478117,
0.008488103,
-0.020321785,
0.035024043,
-0.010833929,
0.0395458,
-0.029090865,
-0.015211934,
0.010788189,
-0.016361978,
0.022765627,
0.008194057,
-0.020151893,
-0.022556528,
0.028202195,
-0.0049955,
-0.0110757,
0.0145977065,
-0.008834423,
0.025078783,
-0.010422266,
0.030476144,
0.04312662,
-0.01309481,
-0.0043976083,
-0.022674147,
0.024882752,
-0.010474541,
-0.01127173,
-0.009690421,
-0.043753915,
-0.009030453,
-0.012062385,
-0.019014917,
-0.029744297,
-0.0040349527,
0.017681913,
-0.0046916534,
-0.017002342,
0.010644434,
-0.009638146,
0.009461719,
0.020125756,
0.035102453,
0.011003822,
-0.0072073727,
-0.0145977065,
-0.015002836,
-0.0062696957,
-0.0008903033,
-0.011480829,
0.005831895,
0.011539638,
-0.01348687,
0.023771916,
-0.026359512,
-0.01348687,
-0.03437061,
0.042760696,
0.0022641474,
-0.014885218,
0.013813587,
0.0089063,
-0.007880409,
0.017302923,
-0.01255246,
0.021811614,
-0.016597213,
-0.015185798,
0.00979497,
-0.0076647764,
-0.022582665,
-0.019250154,
-0.024634447,
0.0008502805,
0.002246178,
0.18724793,
-0.035599064,
0.019433117,
0.042551596,
-0.021707065,
0.0071224263,
0.015577857,
0.010409198,
0.0045544324,
0.036461595,
0.034997903,
-0.01397041,
-0.031234127,
0.0034141906,
-0.0036657625,
0.0078477375,
-0.043858465,
-0.015800025,
0.017250648,
0.0035089385,
0.0026562077,
-0.007965356,
0.0023507273,
-0.014532364,
0.03985945,
0.010389594,
0.006553939,
-0.001339539,
0.026843052,
0.006142276,
-0.009017384,
-0.008644926,
-0.004632844,
0.00944865,
-0.0077039823,
-0.0009752497,
-0.00119415,
-0.009213414,
0.011944766,
-0.0006522084,
0.01244791,
-0.01770805,
-0.016309703,
-0.06053409,
0.006419985,
0.02982271,
0.020779189,
-0.011931698,
0.0018067439,
0.011546172,
-0.025640735,
-0.010781655,
0.0020632166,
0.02479127,
-0.0033488474,
0.005949513,
0.012199606,
0.013656762,
0.0044008754,
0.035102453,
-0.0049955,
-0.014636913,
-0.019093331,
0.02637258,
-0.027888546,
0.016910862,
-0.009481322,
-0.031443227,
-0.0014465387,
-0.024882752,
0.040251512,
0.0069525335,
-0.039598078,
-0.010899273,
0.0077105165,
-0.013375786,
0.0031577179,
0.013147084,
-0.00039206017,
0.030632967,
-0.0057436815,
-0.013062138,
-0.026424855,
0.009533596,
-0.012186537,
-0.044172112,
-0.014649982,
0.0013885464,
-0.007913081,
-0.0008200592,
0.012853039,
-0.021315005,
-0.01565627,
0.0031707867,
0.035860438,
0.0050869808,
-0.006106337,
-0.021288868,
-0.012199606,
-0.024137838,
-0.0146891875,
0.041218594,
0.010389594,
0.037271854,
-0.026359512,
-0.026699297,
-0.029796572,
-0.018191593,
-0.0023229565,
-0.011944766,
-0.0027738258,
-0.033978548,
0.010644434,
-0.02814992,
0.011611516,
0.035180867,
0.02676464,
-0.009559734,
0.013748243,
-0.011043028,
-0.0086057205,
-0.0040970286,
0.031417087,
0.012323758,
-0.0019096597,
0.0009058223,
-0.017694982,
0.00052723923,
0.005351621,
-0.025078783,
0.0012447911,
-0.02008655,
-0.018531376,
0.003334145,
-0.012807298,
-0.012036247,
-0.036409322,
0.0058416966,
-0.02479127,
-0.003597152,
0.0021318272,
-0.0023752311,
-0.008148317,
-0.03259327,
0.03897078,
-0.00886056,
-0.004766798,
-0.0030253977,
-0.023837259,
0.025928246,
-0.023262236,
0.0014424548,
-0.016113672,
0.00037409074,
0.00964468,
-0.015930712,
-0.0011712797,
-0.018714339,
0.0015788589,
-0.01546024,
-0.018165454,
0.023419062,
0.012382567,
-0.013735174,
0.00017509979,
0.020870669,
-0.16341068,
0.028228331,
-0.0014783936,
-0.0074556777,
0.012696215,
-0.006550672,
0.020805327,
0.020635433,
0.003048268,
-0.036670696,
0.018426828,
-0.0049268897,
-0.015277278,
-0.01594378,
-0.01555172,
-0.0024128037,
-0.013748243,
0.028332882,
0.016597213,
0.007566761,
0.035991125,
-0.022203675,
0.019224018,
-0.020413266,
0.025719147,
0.005243805,
-0.013166687,
0.01274849,
-0.012238812,
-0.0045609665,
-0.011944766,
0.017629638,
0.023837259,
0.010827395,
-0.0045544324,
-0.0002666826,
-0.0034501294,
-0.016662557,
0.0009605474,
0.007128961,
0.025287881,
0.035259277,
0.015473308,
0.0078085316,
-0.002536956,
0.029482925,
-0.0060344595,
-0.020151893,
0.007096289,
-0.003043367,
0.0047145234,
-0.01201011,
0.010265443,
0.0027280853,
-0.008795217,
0.00762557,
-0.02007348,
0.0293261,
0.02825447,
-0.013591419,
-0.012166934,
-0.009389841,
0.025431637,
-0.01800863,
0.011977438,
-0.033116017,
-0.031521637,
-0.029639749,
-0.0045936382,
0.004155838,
-0.018374553,
-0.047883615,
-0.0025042843,
-0.01279423,
0.023053138,
0.015590926,
-0.018243866,
0.0064624585,
0.020596227,
-0.013709038,
-0.0154471705,
-0.010566021,
-0.023157688,
-0.025314018,
-0.009657749,
-0.012787696,
-0.0015249507,
0.008409691,
-0.017394403,
-0.01077512,
0.008161386,
-0.0155386515,
-0.0022363765,
-0.02489582,
-0.01515966,
0.013931205,
0.005201332,
0.0012358063,
0.0031593514,
0.014649982,
0.01092541,
-0.022373566,
-0.007462212,
0.030632967,
0.030423868,
0.008651461,
-0.031155715,
-0.006710763,
0.015316484,
-0.023706572,
-0.0034076562,
-0.00669116,
-0.018727407,
0.008684133,
-0.010762052,
0.012101591,
0.006400382,
-0.02105363,
0.036304772,
-0.012983726,
0.051621255,
-0.013042535,
-0.016179016,
0.027496487,
-0.0005133538,
-0.0058841696,
-0.12462286,
0.0035840834,
0.0042636544,
0.029692024,
0.027156701,
0.02067464,
-0.017407471,
0.006684626,
0.012166934,
0.047204044,
-0.002752589,
0.0016205154,
-0.009938725,
-0.002321323,
0.035782024,
0.023876464,
-0.0039761434,
-0.0032426643,
-0.031025028,
0.02480434,
0.019041056,
-0.026895327,
-0.008775613,
0.0076843794,
0.009226482,
-0.011180249,
-0.022491185,
0.023824189,
-0.00063505577,
0.026163481,
0.022661077,
-0.013166687,
0.0018198126,
-0.012670077,
-0.001087967,
-0.023196893,
0.01398348,
-0.011716065,
0.02304007,
0.0064657256,
-0.0012594933,
0.022687215,
0.0018345149,
-0.020622365,
0.006410184,
0.00060810166,
-0.006233757,
-0.010167427,
-0.026150413,
0.001747935,
-0.00351874,
-0.012036247,
-0.02392874,
0.0052764765,
0.010964616,
-0.0007424639,
0.015068179,
-0.0033586489,
-0.0037409074,
-0.017786464,
-0.013499939,
0.01594378,
-0.031939834,
0.011258661,
0.028097646,
-0.007292319,
-0.011853286,
-0.0084292935,
0.0057175444,
0.0057567502,
0.021968437,
0.009154605,
-0.020243373,
0.009579337,
-0.024098631,
0.019341635,
-0.014532364,
-0.006161879,
0.014767599,
-0.02263494,
0.01387893,
-0.009827642,
0.0072400444,
0.006145543,
0.0051196525,
0.021040563,
0.0035252743,
-0.018845025,
0.0058384296,
-0.040199235,
-0.0057240785,
0.034788806,
0.006119406,
-0.021471828,
-0.0059397114,
0.02008655,
0.015421033,
-0.012689681,
0.028019233,
-0.0013983479,
-0.0054333005,
-0.013539145,
-0.043466404,
0.0059364443,
0.014140303,
-0.0075471583,
0.006161879,
-0.0013656763,
-0.0037376403,
-0.014127235,
0.01348687,
0.0016891259,
-0.0098145725,
0.0025353224,
-0.024150906,
0.009050055,
-0.01723758,
-0.027104426,
0.022334361,
0.019276291,
0.021628652,
0.030476144,
-0.006743435,
0.020583158,
-0.008259401,
0.009710023,
0.0031577179,
0.00049620116,
-0.0011435088,
0.035782024,
-0.0022870176,
-0.018557515,
0.01821773,
-0.0065245344,
-0.00076084177,
0.012820368,
0.0018688202,
-0.022844039,
-0.014584638,
0.011977438,
0.009481322,
-0.008200591,
-0.015695475,
-0.028960178,
-0.016884726,
-0.012264949,
-0.023497473,
-0.0039500063,
-0.028280606,
-0.006847984,
0.0143755395,
0.0016695228,
0.019093331,
0.0110757,
0.008880163,
-0.01339539,
-0.040512886,
0.015878437,
0.00625336,
-0.025706079,
0.023784984,
-0.03374331,
0.03808211,
0.0005423499,
0.006665023,
-0.021406485,
0.0018998582,
-0.0156432,
0.0005019187,
0.008350882,
0.00516866,
-0.029744297,
-0.025431637,
0.011036494,
-0.0009180742,
-0.000054469816,
0.01166379,
-0.012166934,
-0.02008655,
0.0029420848,
-0.01457157,
-0.0048909504,
-0.004299593,
-0.0059397114,
-0.020687709,
0.0105725555,
0.024935028,
-0.005462705,
0.0042440514,
0.031025028,
0.006900259,
0.0049726297,
-0.013323511,
0.027339663,
-0.00386506,
0.0023490938,
0.017172236,
0.00920688,
0.0034664653,
-0.0070897546,
0.0019570338,
0.0006432237,
-0.017276784,
0.001068364,
-0.012800764,
-0.0067630378,
-0.006861053,
-0.0084292935,
-0.016675625,
-0.033220567,
-0.007749723,
-0.006828381,
0.024255456,
0.009566268,
-0.01958994,
0.00027750508,
-0.014872149,
0.0074948836,
-0.010945013,
0.024961164,
-0.0061684134,
0.019224018,
-0.00031017678,
0.032959193,
0.016610283,
0.021537172,
0.0072335103,
0.02272642,
0.022621872,
0.00074368913,
0.035259277,
-0.010023671,
-0.020713845,
-0.0018083776,
-0.029456787,
0.0034435953,
0.028411293,
-0.01190556,
0.0015233171,
0.0018524843,
-0.006106337,
0.060795464,
-0.0022249415,
-0.0056260633,
0.01131747,
0.0061520776,
0.039153744,
0.010069412,
0.0023376588,
-0.012709284,
-0.029796572,
0.017211441,
-0.01704155,
0.0011043028,
-0.03384786,
-0.021759339,
0.019420046,
-0.012800764,
0.0028881766,
-0.016179016,
-0.00551498,
-0.004760264,
-0.015891505,
0.016806312,
0.0037866477,
-0.020099618,
-0.008808285,
0.04252546,
-0.0021220257,
-0.0019292628,
-0.030946616,
-0.0009981198,
0.020909876,
-0.028463569,
-0.0051065837,
-0.008553446,
-0.019812107,
-0.0024569104,
-0.033926275,
0.00014508268,
0.008461965,
0.011219455,
0.02943065,
-0.012800764,
-0.019158674,
-0.018688202,
-0.010075946,
-0.0060115894,
0.0039336705,
-0.0334558
] |
The motor protein Kif3a and primary cilia regulate important developmental processes, but their roles in skeletogenesis remain ill-defined. Here we created mice deficient in Kif3a in cartilage and focused on the cranial base and synchondroses. Kif3a deficiency caused cranial base growth retardation and dysmorphogenesis, which were evident in neonatal animals by anatomical and micro-computed tomography (microCT) inspection. Kif3a deficiency also changed synchondrosis growth plate organization and function, and the severity of these changes increased over time. By postnatal day (P)7
|
[
-0.0134141585,
0.0052978615,
-0.0053610103,
-0.026921378,
-0.02672196,
0.028875671,
-0.04126615,
0.01120727,
0.00096966815,
-0.005527192,
0.031986587,
-0.0024378803,
0.0396974,
-0.009472337,
-0.009685049,
-0.008309067,
0.017083442,
-0.021523809,
-0.008249242,
0.0063281856,
-0.003705844,
0.016578251,
-0.0026123708,
-0.040654603,
-0.0033635106,
0.012968793,
0.014849965,
-0.031800464,
-0.004250919,
-0.027360097,
0.020500131,
-0.0069862637,
0.0124569535,
-0.0075911637,
-0.015448218,
0.023637636,
0.024687901,
-0.031561162,
0.022348067,
-0.007325274,
0.017548751,
0.00856831,
-0.007896937,
0.0040515014,
-0.015873643,
-0.007584517,
0.013693343,
0.0010918115,
0.0025891054,
-0.0027552866,
-0.007272096,
0.021005323,
-0.00095720455,
0.011778934,
-0.0031574457,
-0.012437012,
0.007750698,
-0.012144533,
-0.00078146777,
-0.007305332,
-0.0050485893,
-0.00675361,
-0.0039484687,
-0.0037257858,
-0.0014740286,
0.0070062056,
-0.015235506,
-0.00030888958,
0.0016992043,
-0.012284125,
0.02940745,
0.02940745,
-0.01663143,
-0.016352244,
0.02055331,
-0.011938468,
0.0030793403,
-0.0032023145,
-0.024528367,
0.0075712223,
0.007863701,
-0.0039451453,
-0.008940556,
0.028583191,
0.012536721,
-0.010821729,
0.025711577,
0.01972905,
0.01825336,
0.0126763135,
0.0071391505,
0.019303625,
0.018944673,
0.0012712873,
-0.027519632,
0.0033302743,
0.00066887995,
0.02592429,
-0.009598634,
-0.018944673,
-0.009472337,
0.0005529684,
-0.005490632,
-0.017588634,
-0.020513427,
-0.002191932,
0.00003990949,
-0.004569987,
0.028078001,
-0.034166884,
-0.037889346,
0.037969116,
0.019649282,
-0.041532043,
0.0077440506,
-0.03294379,
0.020274125,
0.012064766,
0.007272096,
-0.0017349332,
0.01931692,
0.03342239,
0.012244241,
-0.021842876,
0.0012638092,
0.0112803895,
-0.019183975,
0.0035762226,
-0.035017733,
-0.014637253,
0.0064644543,
-0.0022567427,
0.022853259,
0.0174291,
-0.019715754,
0.013101737,
-0.03164093,
-0.0010161989,
-0.0061420626,
-0.04615853,
-0.00999747,
0.016764374,
-0.026349714,
-0.0020274124,
0.010230124,
0.003609459,
-0.002298288,
-0.0073319213,
0.0068200827,
0.0020257507,
0.021457335,
-0.003705844,
0.02379717,
-0.0069330856,
0.025193091,
0.0066505778,
-0.01270955,
0.029221328,
-0.0023614368,
-0.023783874,
-0.012437012,
-0.02214865,
0.011778934,
-0.0044868966,
0.026708666,
0.013547104,
0.005803053,
0.0114266295,
0.006540898,
-0.02553875,
0.004330686,
0.021909349,
-0.015567869,
0.0017050207,
-0.019330215,
-0.00015548343,
0.01527539,
0.016259182,
-0.035496335,
-0.021124972,
-0.01539504,
0.010283302,
0.014504308,
-0.008601546,
-0.014504308,
0.009758169,
0.013693343,
-0.032704487,
0.0070261476,
-0.0030760167,
-0.0061354153,
-0.009598634,
-0.004676343,
-0.031747285,
-0.6338821,
-0.031986587,
0.012895673,
-0.0198487,
0.0029497189,
0.054135237,
-0.0056701074,
-0.023783874,
-0.00573658,
0.0037789638,
-0.006308244,
0.017748168,
0.006966322,
-0.008674666,
-0.028184356,
-0.03671943,
0.014105473,
-0.026456071,
0.024355538,
-0.00054258213,
-0.031215504,
-0.013181505,
0.0063647456,
0.036825787,
-0.008920615,
0.005550457,
0.027785521,
0.0021254595,
0.0049123205,
0.026854906,
-0.007777287,
0.032199297,
-0.027519632,
0.0034765138,
0.052805785,
-0.01498291,
-0.0101370625,
0.013247977,
-0.0014740286,
0.039006084,
-0.011293684,
0.012437012,
0.040096235,
0.007890291,
-0.0014291595,
0.0007411688,
-0.0043074205,
-0.0017548751,
0.013852878,
-0.013400864,
-0.0062650368,
0.0062783314,
-0.022068882,
-0.0019277036,
0.0047594337,
-0.009379275,
0.030205121,
0.0007145798,
0.008023235,
0.008501838,
-0.0025409127,
0.03182705,
-0.0222683,
-0.014650548,
-0.0006842517,
0.0056269006,
-0.0082625365,
-0.0077108145,
0.004367246,
-0.00358287,
0.036852375,
0.014903143,
-0.010143709,
0.02672196,
0.004091385,
0.030311478,
-0.009419159,
-0.003679255,
0.0030344713,
-0.004606547,
-0.009897761,
-0.006514309,
-0.028317302,
-0.0014997866,
0.018771846,
-0.010283302,
-0.04748798,
0.026349714,
-0.01675108,
-0.0007004544,
0.02149722,
0.011871995,
0.002582458,
-0.038235005,
-0.015062678,
0.00407809,
0.008116297,
0.012643077,
0.0146638425,
-0.017575338,
-0.004001647,
0.015262095,
-0.0007116716,
-0.016059766,
0.008435365,
0.0017000352,
-0.018678784,
0.012842495,
0.0375171,
-0.03432642,
-0.013786404,
-0.008023235,
-0.014012411,
-0.025432393,
-0.007444924,
-0.012257536,
-0.0032305655,
0.0045035146,
-0.013128326,
-0.007943468,
-0.012383834,
-0.009891114,
0.020686254,
0.0063813636,
0.033927582,
-0.0032471835,
-0.0064112763,
0.003439954,
-0.015102561,
-0.009625223,
0.0052347123,
0.008860789,
0.017495573,
-0.019516338,
0.035203855,
0.014358069,
0.015714109,
-0.0022916407,
0.0021404158,
-0.024089647,
-0.034991145,
-0.006630636,
-0.0018296567,
0.0046896376,
-0.0033269506,
-0.008069767,
-0.010110473,
-0.014690431,
0.022773491,
0.0100639425,
-0.015488101,
-0.021603575,
-0.005799729,
0.0071059144,
0.0021287831,
-0.009007029,
-0.0056368713,
-0.003662637,
0.014956322,
-0.040947083,
-0.0071391505,
0.016737785,
-0.01958281,
0.0032554925,
-0.016564956,
-0.009811346,
-0.00012193556,
0.003082664,
-0.005819671,
-0.018864907,
-0.020925555,
-0.0038088765,
-0.025232976,
0.009698343,
0.0023564515,
0.013181505,
0.0121245915,
0.008621489,
-0.004589929,
-0.0063813636,
-0.004925615,
-0.0258977,
-0.022507602,
-0.014105473,
0.024408717,
0.014198534,
0.026163591,
0.016551662,
0.0055471333,
0.047860228,
-0.009678402,
-0.0060357065,
-0.023557868,
0.0062783314,
0.0012837509,
-0.048365418,
0.022494307,
0.0021686666,
-0.016551662,
0.023571162,
0.010708726,
-0.006690461,
0.008707902,
0.001096797,
0.026203474,
-0.026682077,
-0.005440777,
-0.019516338,
-0.016139533,
0.004044854,
-0.0022750227,
0.015940115,
0.009286214,
-0.00069380715,
0.01113415,
-0.0045201327,
-0.013354333,
-0.021563692,
-0.022786787,
-0.004666372,
0.0025076766,
-0.005756522,
0.030683724,
-0.0029962496,
0.01616612,
0.009153268,
0.009678402,
0.019928467,
0.020154474,
-0.011287037,
-0.023012793,
0.014810082,
0.0076775784,
0.022547485,
-0.008289126,
0.03166752,
-0.009751521,
-0.008129591,
0.027466454,
-0.0037291094,
0.017974176,
0.030338068,
-0.0025591927,
0.001861231,
-0.0030411186,
-0.020327302,
0.029354272,
-0.018745257,
-0.021696636,
0.014198534,
0.0010278317,
0.00825589,
-0.010967969,
0.0038819963,
0.004955528,
-0.032704487,
0.010369716,
0.026150297,
0.02117815,
0.030683724,
0.014703725,
-0.012330656,
0.016564956,
-0.01946316,
0.020181064,
0.01471702,
-0.013075149,
0.01033648,
-0.013121679,
-0.020619782,
-0.015288684,
0.014411246,
0.023331862,
-0.041691575,
0.023930114,
0.006540898,
0.016418718,
0.008947204,
0.009984176,
0.009472337,
0.0009729918,
-0.049535338,
0.012749433,
0.005816347,
-0.02023424,
0.00078894594,
-0.009312803,
0.0126031935,
-0.0050751786,
0.017242977,
-0.018705372,
-0.0026505925,
0.008588252,
-0.010642254,
0.00018342266,
-0.0057764635,
0.011772287,
0.000113314905,
0.010376363,
-0.01113415,
-0.016764374,
0.004613194,
0.007850407,
0.013374275,
0.03998988,
0.005164916,
-0.02229489,
-0.006085561,
-0.024315655,
-0.0041379156,
0.008196064,
-0.014411246,
0.001460734,
-0.008249242,
-0.008249242,
-0.011047736,
0.019197268,
0.0018213476,
0.01940998,
-0.0011557912,
-0.02229489,
-0.021005323,
-0.0052347123,
-0.004729521,
0.015235506,
0.03866043,
0.008681314,
0.038554072,
0.010609018,
0.024196004,
-0.001523883,
-0.009711638,
0.020540014,
-0.026243359,
-0.013420805,
0.0045733107,
0.029008616,
0.013081796,
-0.010469425,
0.019183975,
-0.0046464303,
-0.00008459669,
-0.016950497,
0.009798053,
0.033661693,
0.009133327,
0.03881996,
0.042010646,
0.002858319,
0.0046996083,
0.00086580485,
0.060569778,
0.0050352947,
-0.013148269,
0.01098791,
0.006959675,
-0.0060988553,
0.004918968,
-0.0015745682,
-0.028982027,
0.009904408,
0.027891878,
-0.008847495,
0.034193475,
0.00056377024,
0.0030810023,
0.010668842,
-0.017442394,
0.00743163,
-0.00946569,
0.012982087,
-0.0077307564,
-0.00007130219,
-0.01931692,
0.024967086,
-0.020194357,
0.0095853405,
-0.0032870672,
0.047674105,
-0.016897319,
-0.0003626908,
-0.011599458,
0.018745257,
-0.015501396,
-0.0064179236,
-0.011413335,
-0.020898966,
0.00030390415,
-0.0066140178,
-0.026735255,
0.0077108145,
0.010702079,
-0.03618765,
-0.022387952,
0.018519249,
-0.016777668,
-0.03164093,
-0.006780199,
0.013640165,
0.03645354,
0.03780958,
-0.009159916,
0.004935586,
0.02689479,
0.0066705192,
-0.032199297,
-0.0068732607,
-0.023265388,
-0.003270449,
0.020300714,
0.023172326,
-0.008528427,
-0.00898044,
-0.0054839845,
0.016112944,
0.016963791,
0.005533839,
-0.013347686,
-0.018811729,
-0.02294632,
0.027027734,
0.033954173,
-0.0014067251,
-0.0106887845,
0.000058267335,
-0.017508866,
-0.0056368713,
-0.0114997495,
-0.024874024,
-0.028476836,
-0.0065508685,
0.016884025,
-0.007584517,
-0.0048624664,
-0.0062118587,
-0.024315655,
0.004267537,
-0.005766493,
0.0174291,
0.027493043,
0.00048691136,
0.01566093,
-0.004473602,
-0.017508866,
0.017269565,
-0.024887318,
0.031747285,
0.01316821,
-0.014743609,
0.0065541924,
0.00411465,
-0.024382127,
-0.019649282,
0.0068732607,
-0.01418524,
0.033103324,
-0.0015920174,
-0.033555336,
-0.002771905,
-0.005158269,
-0.009611929,
0.0041113268,
-0.00035147354,
-0.0048126117,
-0.007378452,
-0.0014648886,
0.019223858,
-0.037915938,
0.017535456,
-0.031242093,
-0.02069955,
0.009545457,
-0.0052878903,
-0.02359775,
-0.023863642,
0.011672578,
-0.0151424445,
-0.028716138,
-0.015767286,
-0.05022665,
0.015753992,
-0.0050485893,
0.01745569,
0.028875671,
0.02781211,
0.0073518627,
0.015581164,
0.017628517,
0.007923527,
-0.0048325537,
-0.0056368713,
0.026429482,
-0.04049507,
0.03347557,
0.023252094,
0.011240507,
0.030444423,
-0.014557486,
0.0010220152,
0.029380862,
-0.018532544,
-0.02011459,
0.0134141585,
-0.020500131,
-0.014677136,
0.012430365,
-0.0036593133,
-0.0044237473,
-0.02698785,
0.013294508,
0.0210585,
0.014118767,
-0.015036088,
-0.005909409,
0.0210585,
-0.013387569,
0.042462658,
-0.022520896,
0.0035928406,
0.0036294006,
-0.0073518627,
0.0060091177,
-0.013234682,
-0.0064146,
-0.008614841,
0.025113326,
0.0031690784,
-0.015461513,
-0.011951762,
0.00039800434,
-0.0100639425,
-0.014291596,
-0.035257034,
-0.032305654,
-0.020300714,
-0.034166884,
-0.0088142585,
-0.023531279,
0.004294126,
0.012104649,
-0.031401627,
0.014344774,
0.0024262476,
-0.007950116,
0.029088384,
-0.019915173,
0.025711577,
-0.025857817,
0.018678784,
0.0050818254,
-0.0012903982,
-0.009419159,
-0.011732403,
0.016644724,
0.00388532,
0.04296785,
0.028264124,
-0.01195841,
-0.008761081,
0.0045201327,
0.013613576,
-0.021696636,
-0.03398076,
-0.0088142585,
0.001381798,
0.02604394,
-0.00070086983,
-0.0006618172,
-0.01955622,
0.0081894165,
-0.0071125617,
-0.016564956,
-0.0072588013,
-0.007458219,
-0.026416186,
0.014171945,
-0.0074715135,
0.013174857,
0.01893138,
0.021164857,
0.023318566,
-0.015195622,
-0.01716321,
0.024408717,
-0.0020888995,
0.020034824,
0.008654725,
0.017708285,
-0.0031424894,
0.007444924,
-0.010442836,
-0.017110031,
-0.018864907,
0.04020259,
-0.009492279,
-0.012417071,
-0.017721578,
-0.0118321115,
-0.011918526,
-0.018532544,
-0.004616518,
-0.011639342,
-0.036878966,
0.009186505,
0.028530015,
0.0042741843,
-0.0095853405,
-0.015248801,
-0.025552044,
-0.012343951,
-0.021231329,
-0.009133327,
0.007923527,
-0.045174737,
-0.018851612,
0.009472337,
0.01810712,
0.016432012,
-0.0018296567,
-0.0134341,
0.016910614,
0.03055078,
0.0011441585,
0.02592429,
-0.0068001407,
-0.015195622,
-0.03754369,
-0.00018820037,
-0.030284889,
-0.025631811,
0.0051350035,
-0.03881996,
-0.044722725,
0.0035695753,
0.008402129,
0.028822493,
0.003918556,
0.0026971232,
0.010908144,
-0.008967145,
0.02536592,
0.0057232855,
-0.010296596,
0.017203093,
-0.009100091,
-0.009791405,
-0.0045134854,
-0.0038819963,
0.004177799,
0.016272478,
-0.0039119087,
0.0056269006,
-0.021842876,
0.0072986847,
0.00028915555,
-0.0010053972,
-0.012463601,
-0.0053078323,
-0.018279947,
-0.031242093,
-0.024315655,
-0.0016493499,
0.012290772,
-0.018825023,
-0.010589075,
-0.00032405363,
-0.01486326,
0.021869466,
-0.022959614,
-0.010841671,
0.009166563,
-0.02521968,
-0.035283625,
0.0102500655,
-0.016405422,
0.048737668,
0.008076414,
-0.0030461042,
-0.01699038,
-0.013852878,
-0.049322624,
-0.00890732,
0.007272096,
-0.0036061353,
0.011213917,
-0.007046089,
-0.0040747668,
0.013008676,
-0.022667136,
0.002487735,
0.009791405,
-0.02023424,
0.0008865775,
-0.001994176,
0.02474108,
0.016099649,
0.0019277036,
-0.020779315,
0.02282667,
0.008342303,
-0.016857436,
0.024235887,
-0.0018595693,
0.0064877197,
-0.008920615,
0.021164857,
0.0065541924,
0.022494307,
0.011712462,
-0.031800464,
-0.018798433,
-0.0074715135,
0.0009912717,
0.0073518627,
0.021896055,
-0.016671313,
0.0007295361,
0.0014682122,
0.000988779,
-0.0033984086,
0.009631871,
-0.014464425,
0.0113535095,
0.008953851,
0.017974176,
0.013593635,
0.030045588,
-0.012171122,
-0.0015994954,
0.003975058,
-0.012018235,
0.016285772,
-0.010329832,
-0.0016177754,
0.0056169294,
0.011287037,
-0.006388011,
-0.037038498,
-0.012908967,
-0.010668842,
0.008827553,
-0.020141179,
0.010702079,
-0.01972905,
-0.0081894165,
0.0035529572,
0.02636301,
-0.017149916,
-0.021802993,
-0.004330686,
-0.009259624,
-0.025764756,
-0.016272478,
0.025352627,
-0.0124569535,
0.0049289386,
0.00086995936,
-0.008395482,
-0.0005035295,
0.01554128,
0.19175997,
-0.001157453,
-0.00992435,
0.00024885658,
-0.021164857,
-0.027439864,
0.016099649,
0.009671754,
-0.004889055,
0.0032621399,
0.026097119,
0.003029486,
-0.0040348833,
0.0065741343,
0.019277036,
-0.00830242,
-0.0012812582,
-0.011871995,
-0.028237535,
-0.018971262,
0.023757286,
-0.019210564,
-0.0020423688,
0.013719932,
0.03079008,
0.00611215,
-0.02621677,
0.01147316,
0.0006443682,
0.0035928406,
-0.044403657,
-0.012556663,
-0.0020107944,
-0.021776404,
-0.020327302,
0.007145798,
-0.034485955,
0.0022849934,
0.004357275,
0.009911056,
0.0057964055,
-0.008628136,
0.024315655,
0.017508866,
-0.00042397017,
0.028530015,
0.020473542,
-0.0018844965,
-0.002173652,
0.002316568,
-0.05807041,
0.014597369,
0.03382123,
0.016591545,
-0.0037357567,
-0.0103231855,
0.007564575,
0.010010764,
0.015049383,
0.023690812,
-0.03427324,
0.0060190884,
-0.023451513,
0.01890479,
-0.036799196,
0.015355157,
-0.006324862,
-0.006610694,
0.006128768,
-0.04435048,
-0.018957969,
-0.013081796,
-0.010795141,
0.013081796,
0.0053610103,
-0.03538998,
0.04480249,
0.009346039,
0.0075911637,
0.016671313,
0.01713662,
-0.017974176,
-0.020486837,
0.0041478863,
-0.0045367507,
-0.018984558,
0.01784123,
0.025964174,
0.005852907,
-0.024023175,
-0.0026755198,
-0.015501396,
0.004935586,
-0.008382187,
0.0029879406,
0.0047261976,
0.0003745312,
0.0056734313,
0.0009513882,
0.015049383,
-0.0067635807,
0.05700685,
-0.0035496335,
-0.005806376,
-0.0029613515,
0.009598634,
0.0050685313,
0.013247977,
-0.027625987,
-0.030896436,
0.015049383,
-0.01728286,
0.00543413,
-0.00018695401,
0.0016102972,
0.0017133297,
0.00825589,
-0.020579899,
0.025339331,
-0.0035396628,
-0.002522633,
-0.00031179775,
0.023278683,
0.041797932,
-0.018412894,
-0.002798494,
-0.027625987,
-0.0024129532,
0.010562486,
-0.03371487,
-0.0035695753,
0.0059359977,
0.0035562809,
0.016206006,
-0.016578251,
-0.006966322,
0.039936703,
0.004437042,
0.004390511,
0.0067835227,
-0.016033176,
-0.0077307564,
0.012523427,
0.0022068883,
0.0038720253,
-0.014530897,
0.019516338,
0.024235887,
-0.04286149,
-0.028503425,
-0.030098766,
-0.0043705693,
0.012417071,
-0.01778805,
0.015873643,
-0.013852878,
-0.0013269581,
-0.011818818,
0.00818277,
0.0076775784,
-0.021696636,
0.0100639425,
0.001140004,
0.0061885933,
-0.017322743,
-0.023145739,
-0.16697901,
-0.015780581,
0.013128326,
-0.027360097,
0.021683343,
0.0023996586,
0.03961763,
-0.013906055,
0.007757345,
-0.0029580279,
0.03193341,
0.00931945,
-0.021696636,
-0.0268682,
0.008820906,
-0.0040315595,
-0.036028117,
0.028450247,
0.0066937846,
0.0174291,
0.023252094,
-0.019356804,
0.022693725,
-0.006530927,
-0.006391335,
0.028875671,
0.0069862637,
-0.03079008,
0.0032837435,
-0.029832875,
-0.021191446,
-0.012084708,
0.028264124,
0.012304067,
0.013367628,
-0.016884025,
0.00017552904,
0.012111297,
-0.010854966,
0.014823376,
-0.0038122002,
0.03483161,
0.009272919,
-0.0064511597,
0.0018977909,
0.018918084,
-0.008854142,
0.0067602573,
0.039936703,
-0.03403394,
0.015594457,
-0.0035762226,
-0.0038687019,
0.015421629,
0.02132439,
0.01660484,
0.011227212,
0.009445747,
-0.013400864,
-0.021989116,
-0.010622311,
0.0012970454,
0.036932144,
-0.01808053,
0.004240948,
-0.0053410684,
0.006584105,
0.030683724,
-0.03427324,
0.017974176,
-0.019144092,
-0.0049156444,
0.003705844,
-0.018519249,
0.02311915,
0.030923026,
-0.004663049,
0.0041645044,
-0.0035662518,
0.0045932527,
-0.018067237,
0.0198487,
-0.029673342,
-0.01905103,
-0.023385039,
0.0138927605,
0.00056003116,
0.00573658,
0.007717462,
0.005527192,
-0.009771463,
-0.018266654,
-0.009279567,
0.009857877,
0.03294379,
0.029221328,
-0.030444423,
-0.015461513,
-0.0012330656,
0.002288317,
0.011579516,
-0.029061794,
0.0067469627,
0.012044824,
0.02117815,
0.009618577,
-0.019170681,
0.038554072,
0.037995704,
0.003172402,
0.007637695,
-0.0031408274,
0.0210585,
0.021138268,
-0.022281595,
0.01931692,
-0.012842495,
0.023757286,
0.008096355,
-0.013573692,
0.053337567,
-0.012317361,
-0.03427324,
0.016564956,
-0.003991676,
-0.00055546116,
-0.13315779,
-0.033156503,
-0.018160298,
0.035336804,
-0.02268043,
0.018200181,
0.0040515014,
0.027865289,
-0.017110031,
0.02701444,
-0.01781464,
-0.01999494,
-0.020805905,
0.006271684,
0.00577314,
-0.017176503,
0.0058994377,
-0.021457335,
0.0045201327,
0.011333568,
-0.011719109,
0.016578251,
-0.017920997,
-0.00032010683,
-0.00931945,
0.003011206,
-0.046903025,
0.014118767,
0.0164586,
0.0044802492,
-0.006780199,
-0.015621047,
0.025020264,
-0.015368451,
-0.015793875,
-0.0020772668,
0.014411246,
-0.028955437,
0.03371487,
-0.027705755,
0.012809258,
0.000022849936,
0.018944673,
-0.010316538,
0.011154092,
0.006082237,
-0.019503042,
0.016697902,
0.019250447,
-0.0048591425,
-0.039378334,
-0.020393776,
-0.015208917,
-0.004666372,
0.033129912,
-0.020513427,
0.011007853,
0.0073319213,
-0.0018363039,
-0.0065907524,
-0.0061420626,
0.0146638425,
-0.008063119,
0.014597369,
0.0033485543,
-0.030205121,
-0.027572809,
-0.03297038,
0.033289447,
-0.029354272,
-0.004038207,
0.0196094,
0.0006451991,
0.0002521802,
-0.02568499,
-0.004560016,
-0.019768933,
-0.0041744756,
0.02701444,
-0.017189799,
-0.009419159,
-0.0196094,
0.03642695,
-0.0131549155,
0.0258977,
0.027918467,
0.01699038,
-0.0041179736,
0.01256331,
-0.009645166,
-0.006388011,
0.016923908,
-0.0048259064,
-0.009532162,
-0.012749433,
0.015767286,
-0.0046098707,
0.008382187,
0.013547104,
0.014610664,
-0.020779315,
-0.016126238,
-0.055198796,
0.012011588,
0.02754622,
-0.0037291094,
0.001818024,
-0.0058495835,
0.013879466,
-0.0065342505,
-0.004181123,
0.018479366,
-0.008687961,
0.0058097,
-0.01391935,
-0.008880732,
-0.02038048,
0.0036061353,
0.039830346,
-0.007464866,
0.04698279,
0.027080912,
0.02863637,
0.005221418,
0.01418524,
0.040122826,
-0.01931692,
-0.0071059144,
-0.009073501,
0.01999494,
0.007890291,
0.006514309,
0.016245889,
-0.0418777,
0.009798053,
-0.01940998,
-0.0013086781,
-0.020154474,
-0.020287419,
0.023385039,
0.022348067,
0.024780963,
-0.006720374,
-0.027519632,
0.019223858,
0.009379275,
0.010130415,
0.0020972085,
-0.03895291,
0.0009497264,
0.0052347123,
-0.0061254445,
0.008029883,
-0.0015521338,
0.00018747333,
-0.0110145,
-0.032199297,
-0.0016609826,
-0.005390923,
0.00037183077,
0.021364274,
-0.005806376,
-0.004962175,
0.01554128,
-0.002512662,
-0.003695873,
0.0071923286,
-0.011100914,
-0.027785521,
0.0071391505,
0.0014823376,
-0.035150677,
-0.044749312,
0.011951762,
0.020314008,
0.012902319,
0.0026489308,
0.004337333,
-0.022959614,
0.0063215387,
-0.0025940908,
0.015115855,
0.031242093,
0.007650989,
-0.019290332,
-0.0027469776,
0.031268682,
-0.0113535095,
-0.008993735,
0.016259182,
-0.0002474025,
-0.002210212,
-0.024461895,
0.025525454,
-0.0027935083,
-0.009120032,
0.032864023,
0.039378334,
0.00057207927,
-0.0072388593,
0.0006073928,
0.026522543,
-0.014397952,
-0.0077440506,
0.00014810913,
-0.01604647,
-0.021829583,
0.026761845,
-0.04456319,
-0.042595603,
-0.0019526308,
-0.022760198,
0.0134341,
0.0032421981,
0.00630492,
0.00570002,
0.009824641,
0.02536592,
0.0071258564,
-0.023385039,
-0.008422071,
0.037144855,
-0.0038354655,
0.0210585,
-0.03079008,
-0.018838318,
0.019237153,
0.0070062056,
0.018359715,
-0.02297291,
0.008774376,
-0.006145386,
0.013108385,
-0.0032056381,
-0.022015706,
0.0049123205,
0.0048259064,
-0.009120032,
0.009545457,
0.008269184,
-0.0068732607,
0.08785011,
-0.01433148,
-0.016910614,
-0.0064877197,
0.008634782,
0.020101296,
-0.0140390005,
0.01861231,
-0.014557486,
-0.005374305,
0.026934672,
-0.014132062,
0.027758932,
-0.0027154032,
-0.009771463,
0.00837554,
-0.007272096,
0.007883643,
0.016471894,
-0.013221388,
0.005254654,
-0.011313627,
0.008601546,
0.023225505,
-0.0346189,
-0.0013045236,
0.023331862,
-0.005317803,
0.012842495,
-0.014384657,
0.0075712223,
0.011911879,
-0.045866054,
-0.0053477157,
0.00017957971,
-0.007690873,
-0.00096634455,
0.0009721609,
0.02217524,
0.00777064,
-0.0015479793,
-0.001987529,
-0.02474108,
-0.004287479,
-0.021537103,
0.0043107443,
0.027360097,
-0.019197268,
-0.018346421
] |
Asthma is one of the most common inflammatory diseases characterized by airway hyperresponsiveness, inflammation, and remodeling. Morin, an active ingredient obtained from Moraceae plants, has been demonstrated to have promising anti-inflammatory activities in a range of disorders. However, its impacts on pulmonary diseases, particularly on asthma, have not been clarified. This study was designed to investigate whether morin alleviates airway inflammation in chronic asthma with an emphasis on oxidative stress modulation. In vivo, ovalbumin- (OVA-) sensitized mice were administered with morin or dexamethasone before challenge. Bronchoalveolar lav
|
[
-0.02136216,
0.0076464554,
-0.020417167,
-0.02848288,
-0.025554733,
0.017182896,
-0.04227179,
-0.01860704,
-0.022307152,
-0.005447018,
-0.004016219,
0.012138498,
0.015239672,
0.009236972,
-0.038598295,
0.01366912,
0.052147627,
-0.0062023466,
-0.0037766437,
-0.01428137,
-0.021668285,
0.019299148,
0.004255795,
0.0011587808,
0.006338772,
0.0024257032,
0.022267224,
-0.057870824,
-0.0144810155,
-0.020350618,
0.010860762,
-0.0034106253,
-0.005021106,
-0.015053336,
-0.01533284,
-0.007307057,
0.009070599,
-0.009323485,
0.0007149835,
-0.022040958,
0.026166983,
-0.014201511,
-0.00023811987,
-0.00039721307,
-0.014387847,
0.009716122,
0.010501399,
-0.044667546,
-0.014028484,
0.000486638,
0.03662845,
0.030106671,
0.0027085356,
-0.005277319,
-0.0033390853,
-0.004348963,
-0.01312342,
0.018127888,
-0.0031594036,
-0.01698325,
-0.006581675,
0.021202443,
-0.029787237,
0.020643434,
0.001187064,
0.022932712,
-0.025341777,
0.011153576,
-0.007979199,
-0.009682848,
0.055581544,
0.042005595,
0.00091670954,
0.00073785963,
0.03125131,
-0.0017485693,
-0.032768622,
0.0056233723,
0.012025366,
-0.0072604725,
0.029707378,
-0.015119884,
-0.021029416,
0.034711845,
0.028536119,
0.01178579,
0.012437968,
0.01038161,
-0.006451905,
-0.0009990636,
-0.010920656,
0.015266291,
0.02733824,
0.0052140974,
-0.029840475,
0.019418936,
0.0024223758,
0.034631986,
-0.0015472593,
-0.010315062,
-0.003720077,
-0.018340845,
-0.0056333547,
-0.013542678,
-0.04059476,
0.0126442695,
-0.010221893,
-0.01806134,
0.02898865,
-0.004878026,
-0.010454814,
0.030532582,
0.0011304974,
-0.036335636,
0.0185538,
0.0020047822,
0.020869698,
0.0035204308,
-0.000022343234,
-0.019911397,
-0.009676194,
0.024237068,
0.0056233723,
-0.015585725,
0.02898865,
-0.017954862,
-0.026366629,
-0.00465176,
-0.012664234,
-0.005696576,
-0.0013076836,
0.013622536,
0.03061244,
-0.024702908,
-0.010900691,
0.04168616,
-0.044135153,
-0.0070941006,
-0.02294602,
-0.005879585,
-0.011752515,
0.012244976,
-0.004492043,
-0.014587494,
-0.015559106,
0.032688763,
0.015239672,
-0.0046018483,
-0.0012993651,
0.0076065264,
0.023252146,
-0.047728788,
0.007340331,
0.0140684135,
0.021056036,
0.008624722,
-0.0007802845,
0.021668285,
-0.032395948,
0.013176659,
0.0245565,
-0.039077446,
-0.0028582704,
-0.0006513462,
0.0026569602,
0.010275132,
0.016850153,
-0.0060426295,
-0.02245356,
0.012191737,
0.0056932485,
0.017142966,
-0.02241363,
0.029281465,
0.021282302,
0.010594566,
0.0051542036,
0.010887382,
0.008744511,
0.007892686,
-0.026686063,
-0.0032625543,
0.039556596,
-0.016650505,
-0.0079592345,
-0.00020879682,
0.02084308,
-0.008591448,
0.0054370356,
-0.030026812,
-0.010840797,
0.032103132,
-0.008651342,
-0.03388664,
-0.6337574,
-0.025261918,
0.008591448,
0.00022792959,
0.018993024,
0.022786304,
0.0140151745,
-0.0022060922,
-0.0017219498,
-0.0009990636,
-0.011925543,
0.008531555,
0.001548923,
-0.009250281,
0.009922424,
-0.022400321,
0.00049620436,
-0.03721408,
0.028695837,
-0.017382544,
-0.0011188515,
0.0000516273,
-0.010774248,
0.0093567595,
-0.004801495,
0.014401157,
0.018367466,
-0.01694332,
-0.0063287895,
0.03455213,
-0.009556405,
0.03186356,
0.028269924,
0.035190996,
0.040914193,
-0.005170841,
-0.021149203,
0.045732327,
0.023531651,
0.0059294966,
-0.017688667,
0.0076331454,
0.036442116,
-0.019006332,
-0.011572834,
0.016104806,
0.024370166,
0.015279601,
0.013642501,
-0.010414884,
-0.0016387638,
0.012657579,
-0.02025745,
-0.005347195,
0.028749075,
0.011905578,
0.01428137,
-0.01014869,
0.0109872045,
0.008178846,
-0.021242373,
0.034765087,
-0.007912651,
-0.02410397,
-0.017875005,
0.0070075872,
-0.00055443455,
0.02520868,
-0.009716122,
-0.0026453142,
0.010834143,
0.024316926,
-0.0064585595,
0.000018053957,
0.02246687,
0.02185462,
0.0028449607,
0.015811991,
-0.01860704,
0.0098226005,
0.015093264,
0.0023708004,
-0.013842148,
-0.022360392,
0.050523836,
-0.023944253,
-0.02634001,
0.00088842626,
-0.012990323,
-0.019072881,
0.020749912,
0.014307989,
0.010880726,
-0.023997491,
-0.0076930397,
0.009409999,
-0.020883009,
0.013096801,
0.007846102,
0.0052007874,
-0.025581352,
0.012444623,
-0.0044820607,
0.00437891,
0.015599036,
0.010002282,
-0.057551388,
0.0032375983,
0.033034816,
-0.012378074,
0.00007190388,
-0.0012885509,
-0.005440363,
-0.032715384,
0.03559029,
-0.010048866,
0.012178428,
-0.02028407,
0.0025837566,
-0.05041736,
0.0070342068,
-0.025714451,
-0.0053738146,
0.021708215,
-0.007173959,
-0.0023109065,
-0.0076065264,
-0.0056932485,
-0.004425494,
-0.013143385,
0.009050635,
-0.023704678,
0.009809291,
0.0016820205,
0.029254846,
-0.013003632,
0.01038161,
0.0038065906,
0.0037832984,
-0.01806134,
-0.0105479825,
-0.0070807906,
0.014827069,
0.007579907,
-0.022653207,
-0.009649574,
-0.0105479825,
0.009103874,
-0.01257772,
0.011679312,
-0.0015347813,
0.0008297802,
-0.026499726,
0.017435782,
0.024303617,
0.011106992,
0.008012474,
0.0020513663,
-0.018008102,
0.010594566,
0.0056899213,
0.008737856,
-0.022679826,
0.004292397,
-0.010401575,
-0.007839447,
-0.027631056,
0.03175708,
-0.0042990516,
-0.038598295,
-0.0041027325,
-0.019405626,
0.007000932,
0.020017875,
0.018447323,
0.01227825,
-0.033141296,
-0.0044288216,
-0.025448255,
0.0062156566,
-0.011952162,
-0.0023109065,
0.0033840057,
-0.0060958685,
0.004182591,
-0.005696576,
0.0081855,
0.015226362,
-0.0054802923,
0.015985018,
-0.012677544,
0.014321298,
0.010947275,
0.017489022,
0.00033981472,
-0.039104067,
0.0053904518,
0.001881667,
0.0096162995,
0.0069676577,
0.0073336763,
-0.017595498,
0.0104681235,
-0.020909628,
0.023757916,
-0.017994791,
-0.0018067996,
-0.016078187,
0.02582093,
-0.0042458125,
-0.008451696,
-0.0005818859,
-0.0064219576,
-0.017888313,
-0.014387847,
0.0107809035,
-0.0011121966,
0.003470519,
0.004531972,
-0.0060426295,
-0.00058022223,
0.004089423,
0.02137547,
-0.0047249636,
-0.037586752,
-0.0025820928,
0.0016163036,
0.0068212505,
0.0044587688,
-0.021056036,
-0.027657675,
0.013030252,
0.0077063492,
0.0015530823,
-0.0021611718,
0.007506703,
-0.0018899855,
-0.017622119,
0.044800643,
0.013402926,
0.013489439,
0.01587854,
0.01287719,
0.0065184534,
0.00087844394,
-0.014733901,
0.028536119,
-0.0022609949,
0.011266709,
-0.00030529255,
0.005423726,
-0.006175727,
0.010062177,
-0.012990323,
-0.02403742,
-0.0117125865,
0.012158463,
0.031331167,
0.057072237,
0.027844012,
0.008684617,
0.014813759,
0.016384311,
0.009323485,
0.019405626,
0.016850153,
-0.005204115,
-0.00983591,
-0.011160231,
-0.020709982,
-0.009922424,
0.011978782,
0.01366912,
-0.03436579,
0.0263267,
0.012324835,
-0.007899341,
0.008504935,
0.014733901,
0.023438482,
-0.015745442,
-0.040275324,
0.0073336763,
0.008272014,
-0.0074867383,
0.010880726,
-0.009969008,
0.009143803,
-0.0058296737,
0.030585822,
-0.004059476,
-0.0033740234,
0.018300915,
-0.006142453,
-0.011353223,
-0.0149468575,
0.005952789,
0.011393152,
0.011519595,
0.0034472272,
-0.007054171,
-0.015865231,
0.011519595,
0.011845684,
0.019844849,
0.010454814,
-0.0072671273,
-0.0027251728,
-0.016823532,
-0.016384311,
0.01973837,
-0.01752895,
0.015079955,
-0.0027917216,
0.0017851712,
0.028403021,
0.014055103,
-0.019951325,
0.038039286,
-0.03838534,
0.0055568237,
-0.02350503,
0.024263687,
0.00990246,
0.023877705,
0.002256004,
-0.019445555,
0.006954348,
0.019432245,
-0.013369651,
-0.013382961,
-0.037080985,
0.012744092,
0.002117915,
-0.012531136,
0.009895804,
0.029281465,
0.01124009,
-0.0048880083,
0.0045719016,
-0.0047449283,
-0.013582607,
-0.014028484,
0.015146503,
0.010374956,
-0.005350522,
0.006285533,
0.015119884,
0.036388874,
0.004159299,
0.0011720905,
0.02906851,
0.023864394,
0.0074268444,
0.011878958,
-0.0011779135,
-0.005134239,
0.024529882,
0.0036868027,
0.0032958286,
0.0012852234,
-0.0013276483,
-0.008558174,
-0.009130494,
0.00628886,
0.03393988,
0.00071165606,
0.017156277,
0.00014734318,
-0.01915274,
-0.00015857328,
-0.000058386162,
-0.0028150135,
-0.007346986,
0.009117183,
-0.0185538,
-0.0014208165,
-0.03548381,
0.027977109,
0.017355923,
-0.010900691,
0.012770711,
-0.023092428,
-0.0076264907,
-0.014547564,
-0.017369233,
0.016064877,
-0.015053336,
-0.028589359,
-0.011952162,
-0.02460974,
0.014853689,
-0.010940621,
0.016863462,
0.011925543,
-0.021002797,
-0.032156374,
0.015945088,
0.040461663,
0.027657675,
0.009070599,
-0.02519537,
0.016291143,
0.0123847285,
0.030026812,
-0.009163768,
0.010195274,
-0.012131844,
0.011173541,
0.0031228017,
0.0009083909,
0.012051985,
-0.044694163,
0.018460633,
0.013509403,
-0.018234367,
0.0035237581,
-0.0112201255,
-0.009137148,
0.0130834915,
0.04613162,
0.00960299,
-0.029707378,
-0.028695837,
0.0024040749,
-0.0039929273,
-0.02085639,
-0.005084327,
0.016770294,
-0.0165041,
0.0095630605,
-0.0020031184,
-0.019472174,
-0.007972544,
0.028083587,
0.0020214194,
-0.01698325,
-0.012038675,
0.013216589,
0.011346567,
-0.021082655,
0.014520945,
-0.00015742947,
-0.015106575,
0.014667353,
-0.009137148,
0.012005401,
0.006069249,
-0.029414563,
0.005553496,
-0.009656229,
0.011406462,
-0.03998251,
-0.002492252,
-0.00710741,
0.00089009,
0.0058130366,
-0.021242373,
-0.051269185,
-0.0053438675,
-0.012118534,
0.013183314,
-0.0040095644,
-0.014095033,
0.006814596,
0.0027334914,
-0.0104947435,
-0.018300915,
0.043762483,
-0.03231609,
-0.015465938,
0.014321298,
-0.028083587,
-0.018513871,
-0.0048148045,
0.005410416,
-0.011992091,
0.00047499195,
-0.021841312,
-0.022639897,
-0.026007265,
-0.009702813,
0.009217007,
0.012051985,
0.044587687,
-0.0098226005,
0.016051566,
0.014161581,
0.0070941006,
-0.008158881,
-0.011546214,
-0.0107542835,
-0.02574107,
0.01318997,
0.030825397,
0.010894036,
0.00037454488,
-0.0049212826,
-0.0063088248,
0.0076464554,
-0.015785372,
-0.011373187,
-0.012051985,
-0.017249444,
-0.018127888,
0.0077529335,
-0.013289792,
0.0022027649,
-0.016836843,
0.0060426295,
0.039556596,
0.013070181,
0.0134362,
-0.026925638,
0.010654461,
-0.021708215,
0.02747134,
0.0020912956,
0.007087446,
-0.022919402,
-0.0052906284,
-0.00077487744,
0.002119579,
-0.014108342,
-0.02904189,
-0.012218357,
0.020643434,
-0.012477897,
-0.005277319,
0.014001864,
0.0012236658,
0.012284906,
0.0033490676,
-0.027604437,
-0.017608808,
-0.01424144,
-0.0036502008,
-0.044800643,
0.03830548,
0.0086047575,
-0.012457932,
0.033913262,
-0.038518436,
0.017595498,
-0.011732551,
-0.011559524,
0.019352388,
-0.014600803,
0.0031361114,
0.023465103,
-0.01641093,
-0.023105739,
0.004016219,
-0.0062988424,
-0.020363929,
0.010607877,
0.014188201,
-0.01693001,
-0.022107506,
0.0093301395,
0.012191737,
-0.010175309,
-0.021016106,
0.018194437,
0.014733901,
0.02515544,
-0.011113647,
-0.024782768,
-0.006501816,
0.02689902,
-0.018686898,
0.022653207,
-0.021428708,
-0.029334705,
-0.010075486,
-0.0053904518,
0.009509821,
0.009749397,
0.01476052,
-0.016038258,
0.0076065264,
-0.009390034,
0.0014773831,
0.0057098856,
0.0003352395,
0.034898184,
-0.003097846,
0.010354991,
0.0052839736,
0.035430573,
0.0017485693,
0.0026735975,
-0.042910658,
0.04338981,
0.00038827056,
-0.0042225206,
0.012025366,
-0.0027218454,
0.017901624,
-0.030985115,
-0.0121251885,
-0.022293843,
-0.0066315862,
0.015292911,
0.03897097,
0.0024606413,
-0.03388664,
0.012970358,
-0.023145668,
-0.007000932,
0.0077063492,
-0.016304452,
-0.0014773831,
0.01014869,
-0.0051774955,
0.008711236,
-0.02792387,
0.007346986,
0.013183314,
-0.0064352676,
-0.008318598,
-0.003334094,
-0.040062368,
0.010255168,
0.0024872608,
0.0038398649,
0.005150876,
0.0034272624,
-0.0034272624,
-0.042564604,
-0.0040960778,
-0.009436618,
-0.043522906,
-0.017715286,
0.0061158333,
-0.022653207,
-0.007713004,
-0.0005739833,
0.005919514,
-0.009489857,
0.0061624176,
0.0032492445,
-0.0057830894,
0.004345636,
-0.031650603,
0.003933033,
0.033167914,
-0.019072881,
-0.01151294,
0.0068944544,
-0.0020962867,
0.019059572,
-0.004861389,
-0.02307912,
-0.031118212,
0.019046262,
-0.020523645,
-0.0069743125,
-0.032529045,
0.00041863346,
-0.011998746,
0.022200674,
-0.0024556501,
-0.0036568558,
-0.0062589133,
-0.005749815,
0.003673493,
-0.013502749,
-0.029840475,
-0.0025837566,
0.0032209612,
0.011532905,
-0.007213888,
-0.022826234,
-0.010880726,
0.02358489,
0.013243209,
-0.020483715,
-0.03945012,
0.00012717057,
-0.037613373,
-0.006272223,
-0.02194779,
0.0010614531,
-0.01859373,
0.004838097,
0.0003845272,
0.01533284,
-0.020164281,
-0.017821765,
0.011612763,
-0.002681916,
0.0075200126,
-0.0306923,
0.04107391,
-0.01256441,
-0.027524577,
-0.036255777,
0.01175917,
-0.0111935055,
-0.0083984565,
0.007233853,
-0.012977013,
0.011699276,
-0.02020421,
0.019964635,
0.0035936343,
-0.004408857,
0.006105851,
-0.0018716846,
-0.008751165,
-0.009942388,
0.012085259,
-0.0037999356,
0.0015422681,
-0.0019082864,
0.006225639,
0.013402926,
0.013196624,
-0.023119047,
-0.012424658,
-0.017089728,
0.011912232,
0.022573348,
-0.014188201,
0.009722778,
-0.005703231,
-0.028775694,
-0.024836008,
-0.0021561806,
0.017648738,
-0.022174055,
-0.008638033,
-0.009363414,
-0.013023597,
0.009709468,
-0.015359459,
-0.018993024,
0.023265455,
-0.008098987,
0.029494422,
-0.0036868027,
0.020150973,
-0.0022693137,
0.007919305,
-0.0021528532,
-0.0027035445,
-0.018008102,
-0.00080191286,
-0.00046916894,
-0.006558383,
-0.0042325025,
-0.011839028,
-0.0004787353,
-0.028190065,
0.0020630124,
0.0052373894,
-0.032156374,
-0.027045427,
0.022972642,
0.18772082,
0.010860762,
-0.027844012,
0.02245356,
0.024423404,
0.0047049993,
0.013382961,
-0.0109872045,
-0.022120817,
0.025022343,
0.029680759,
-0.024356855,
-0.023970872,
-0.0006991782,
0.015093264,
0.0011820728,
-0.0061324704,
0.00019975034,
-0.014733901,
-0.0009649574,
-0.0006837888,
0.0066981353,
0.03066568,
0.001483206,
0.0067513743,
-0.0012436304,
0.007945925,
0.008438386,
-0.0043755826,
-0.0060725766,
-0.018859927,
0.02186793,
-0.0015231353,
0.007979199,
-0.0047449283,
-0.0061624176,
0.004864716,
0.008930847,
0.016291143,
0.0246896,
-0.00027201817,
0.019658512,
-0.0048347693,
-0.0005627532,
-0.0045253173,
0.024902556,
-0.0021628356,
0.007746279,
-0.01971175,
-0.00929021,
-0.035909723,
0.010634496,
0.023904324,
0.018260987,
0.0074201897,
-0.016610578,
0.0059727533,
0.0072005787,
0.004385565,
0.016623886,
-0.018766757,
0.0036335636,
-0.00957637,
0.027497958,
-0.032156374,
0.024942486,
-0.019405626,
-0.029787237,
-0.01917936,
-0.0076930397,
0.009210352,
-0.011233435,
-0.030346246,
0.012298215,
-0.010840797,
0.005190805,
0.008238739,
0.008697926,
-0.004954557,
0.021575116,
-0.008671307,
0.014467706,
-0.045226555,
-0.008052403,
-0.026153672,
-0.03822562,
0.011459701,
0.014813759,
-0.04107391,
0.0075932164,
-0.015026716,
-0.024623051,
0.008691272,
-0.021442018,
0.030745538,
-0.010767593,
0.0040994054,
0.02357158,
-0.010328371,
0.013016942,
-0.026592895,
0.04179264,
-0.010947275,
0.017036488,
0.00792596,
0.004598521,
-0.010235203,
0.006814596,
0.001738587,
0.0113998065,
0.009795981,
-0.03559029,
-0.008877608,
-0.013788909,
-0.015479247,
-0.009855875,
-0.00930352,
-0.024902556,
-0.0035636874,
0.002028074,
0.014693972,
-0.006887799,
-0.010920656,
0.015372769,
0.007433499,
0.0071539944,
-0.0075532873,
0.008291978,
-0.022174055,
-0.0426977,
-0.016024947,
-0.009609644,
0.029867094,
0.012830606,
0.0031411026,
-0.0034405722,
0.010980549,
-0.030319627,
-0.0072804373,
0.007346986,
-0.021641664,
-0.018367466,
0.022520108,
0.0068611796,
0.021268992,
-0.0008272846,
-0.01702318,
0.0069343834,
-0.0024556501,
-0.005500257,
-0.023438482,
-0.024356855,
0.00875782,
-0.023957564,
0.02677923,
-0.013429545,
-0.013622536,
-0.010787558,
0.006468542,
0.025381707,
-0.04546613,
0.016756983,
0.004914628,
0.022866163,
-0.015386079,
0.005370487,
-0.1673835,
0.022533419,
0.025235299,
-0.008345217,
0.011699276,
0.008504935,
0.019339077,
-0.010914001,
-0.00046833706,
-0.003906414,
0.033700306,
0.0071539944,
-0.004089423,
-0.02733824,
0.029254846,
-0.016756983,
0.014134962,
0.03063906,
0.026952257,
0.017169587,
0.026765922,
-0.026459796,
0.016304452,
-0.02952104,
0.0005432045,
0.02406404,
0.013602572,
0.026699373,
0.0052606813,
-0.022733064,
-0.014228131,
-0.012717472,
0.02624684,
0.008158881,
0.022347081,
-0.016863462,
0.017968172,
-0.019991254,
-0.0028183411,
0.013762289,
0.015985018,
0.018127888,
0.00089757674,
-0.007220543,
-0.04442797,
0.0107809035,
0.016091496,
0.008857643,
0.035270855,
0.0058429833,
0.038145762,
-0.013130075,
0.0022044284,
0.022373702,
0.016690435,
0.020230832,
0.009782671,
0.00576978,
-0.020057803,
-0.018833306,
0.000019080784,
-0.000037225727,
0.014587494,
0.023398552,
0.031544123,
-0.0012170109,
0.0022110834,
0.014986786,
-0.03008005,
0.020310689,
-0.013303102,
0.0095364405,
0.012264941,
0.015505867,
0.022200674,
-0.0072405078,
0.0029298102,
0.019072881,
0.006248931,
0.022187365,
-0.024024112,
0.010015592,
-0.028243305,
0.013229898,
0.0074268444,
0.042005595,
0.016171355,
-0.0029697395,
0.0013925333,
0.007945925,
0.041819256,
-0.042937275,
0.019006332,
-0.004621813,
0.0246896,
0.02246687,
0.006491834,
0.006628259,
-0.00039450952,
-0.01373567,
0.016650505,
-0.016956631,
-0.0061025238,
0.0060326476,
0.008937502,
-0.003250908,
-0.016530719,
-0.0061457804,
0.032768622,
-0.030266387,
0.010181964,
0.0062622405,
0.0061158333,
0.018167818,
-0.036495354,
0.010760939,
0.014108342,
-0.0015730469,
0.0060925414,
-0.018753449,
0.063833594,
0.007546632,
0.0040661306,
0.020709982,
-0.007067481,
-0.035776626,
-0.11233435,
-0.03556367,
0.0025804292,
-0.015745442,
-0.03830548,
0.015638964,
-0.017422471,
0.016264522,
0.006242276,
0.0113998065,
-0.0064119752,
-0.0055468413,
0.01069439,
-0.004618486,
0.020723293,
-0.010168654,
-0.012491207,
-0.0075532873,
-0.0015838611,
0.037879568,
-0.02294602,
-0.027764153,
0.016557338,
-0.0038831215,
0.005004469,
-0.009250281,
-0.006867835,
0.010661115,
0.010654461,
0.022440251,
0.012491207,
0.01204533,
0.014454396,
0.009010705,
-0.01867359,
0.0031194743,
-0.014747211,
-0.0077063492,
0.01590516,
-0.008378492,
0.01315004,
0.0016038257,
0.0071939235,
0.0013043561,
0.023358624,
-0.011000514,
-0.024516573,
0.020443786,
0.00049869996,
0.0005831337,
-0.0009108865,
-0.020976176,
-0.017169587,
-0.027710915,
0.02631339,
-0.010727664,
0.011725896,
0.024263687,
-0.025634592,
-0.0060759042,
0.009682848,
-0.0016953303,
-0.0061990195,
0.02185462,
0.028855553,
-0.03668169,
0.01643755,
-0.018780068,
0.021641664,
-0.024836008,
-0.013622536,
0.00004978161,
-0.010794213,
-0.010727664,
-0.017608808,
-0.004901318,
-0.033513967,
-0.02299926,
0.0114530455,
-0.010374956,
0.003606944,
-0.0154393185,
0.01699656,
-0.017475711,
0.009177078,
0.037560135,
-0.007433499,
-0.024276996,
-0.00437891,
-0.039317023,
-0.026885709,
0.024623051,
0.0043423083,
-0.011845684,
-0.0014940202,
-0.003909741,
0.013389615,
0.0024257032,
0.019924706,
0.015678894,
-0.026792541,
-0.026007265,
-0.062236425,
0.02357158,
0.021601737,
0.017608808,
0.0021678268,
-0.022746375,
0.03444565,
-0.0050410703,
0.020137662,
0.016331071,
-0.03186356,
0.011153576,
0.010634496,
0.002959757,
-0.012837261,
-0.005287301,
0.021561807,
0.002760111,
0.016477479,
-0.006461887,
0.024969105,
-0.0039563254,
0.01702318,
0.011652692,
-0.023265455,
0.008451696,
-0.020337308,
0.0007881872,
-0.022706445,
0.002831651,
-0.009250281,
-0.03130455,
0.0071539944,
0.02575438,
-0.02685909,
-0.01920598,
0.004126025,
0.017755216,
-0.0029048545,
0.012497862,
-0.020989487,
-0.03298158,
0.02089632,
-0.01257772,
0.014654042,
-0.012238322,
-0.03503128,
0.048447516,
0.01696994,
-0.03779971,
0.03838534,
0.009869185,
-0.024969105,
-0.043176852,
0.0040428387,
-0.0009990636,
0.027444718,
-0.0073736054,
-0.015612345,
-0.02515544,
0.01178579,
0.019578652,
0.018234367,
-0.005347195,
0.0040794406,
-0.014427776,
-0.018394085,
-0.020590194,
0.015865231,
-0.0087312,
-0.011659347,
-0.023984183,
-0.0093301395,
-0.0051542036,
0.019285837,
0.0274181,
-0.0021095965,
-0.00038348738,
-0.0140684135,
0.033806782,
0.017861694,
-0.003969635,
-0.013975245,
0.033141296,
0.008065713,
0.008811059,
-0.047302876,
0.017315993,
0.023198906,
0.011932197,
0.0029115092,
0.00986253,
0.00090007234,
-0.019498793,
0.0062688957,
0.018300915,
0.018500563,
-0.01917936,
0.0285095,
0.013642501,
0.010361646,
0.020696672,
-0.0022426941,
-0.03332763,
-0.017103037,
-0.0126442695,
-0.023238836,
-0.023757916,
-0.015106575,
0.008657997,
0.0112534,
0.0058163637,
0.009622955,
0.003933033,
-0.014095033,
-0.0009882494,
-0.0058962223,
-0.004545282,
0.0070608263,
0.04493374,
-0.0021811365,
-0.0028100226,
0.01096724,
0.007526668,
-0.000011886497,
0.010235203,
0.017156277,
-0.027817393,
0.0104681235,
0.0077063492,
0.021548497,
-0.0135759525,
-0.03127793,
-0.0128239505,
0.00076863845,
-0.02020421,
0.015079955,
0.03447227,
-0.009869185,
0.08667314,
-0.009809291,
-0.016091496,
0.011100337,
0.0041027325,
0.0022959332,
-0.006006028,
0.021495258,
-0.00022002692,
-0.003756679,
0.013243209,
-0.016384311,
0.0075932164,
-0.012218357,
-0.03790619,
-0.004605176,
-0.017422471,
0.012477897,
0.013589262,
-0.011120302,
0.02906851,
0.016064877,
-0.0033623774,
-0.019219289,
-0.05094975,
-0.007140685,
0.011985436,
-0.028882172,
-0.014001864,
-0.015159814,
0.0036568558,
0.03455213,
-0.031437647,
-0.018181128,
0.003756679,
-0.030585822,
-0.0007037534,
-0.013788909,
0.0042990516,
0.017129658,
-0.034898184,
0.020523645,
-0.01807465,
-0.022560038,
0.008897573,
-0.017262755,
-0.013023597,
-0.0005739833,
-0.019991254
] |
The expression of self-antigen in the thymus is believed to be responsible for the deletion of autoreactive T lymphocytes, a critical process in the maintenance of unresponsiveness to self. The Autoimmune regulator (Aire) gene, which is defective in the disorder autoimmune polyglandular syndrome type 1, has been shown to promote the thymic expression of self-antigens. A clear link, however, between specific thymic self-antigens and a single autoimmune phenotype in this model has been lacking. We show that autoimmune eye disease in aire-deficient mice develops as a result of
|
[
-0.037725206,
0.0007710523,
-0.005396949,
-0.01934352,
-0.021307262,
0.010800578,
-0.009718516,
0.0006453963,
-0.01253054,
-0.013559166,
0.027051538,
-0.0067328275,
0.0026016233,
0.0011864271,
-0.0061417012,
-0.012016227,
0.035026733,
0.02165459,
-0.009785309,
0.004034353,
-0.021574438,
0.028427493,
-0.00053602125,
-0.019156497,
0.009397905,
0.005099716,
0.019597337,
-0.058083996,
-0.020265276,
-0.015536266,
0.01154199,
-0.010292944,
-0.0054804413,
0.0017900772,
-0.0033280072,
-0.021066803,
0.008175576,
-0.012791037,
0.031179404,
0.0054136473,
0.0056774835,
0.020585887,
0.0033113088,
0.019423673,
-0.006836358,
0.006769564,
-0.023992376,
-0.015469473,
-0.0015588031,
0.012911266,
0.020719474,
0.0046321587,
-0.03342368,
-0.013585884,
-0.011635501,
0.004231395,
-0.0029957076,
0.023832072,
0.010874051,
-0.032381695,
0.00065374555,
-0.017125962,
-0.026637416,
0.0015746667,
0.00637548,
0.012350196,
-0.0038439902,
0.0023010506,
0.001957062,
-0.021374056,
0.045767196,
0.034973297,
-0.016645046,
-0.003606872,
0.010720424,
-0.024459934,
0.0063020065,
0.011107829,
-0.017326344,
0.00016020105,
0.0062385523,
-0.015870236,
-0.004004296,
0.019196574,
0.020372147,
0.0057743345,
0.0059880754,
0.009023859,
0.025702301,
0.0024429876,
0.00064998836,
0.016417947,
0.008375958,
0.03219467,
0.0052032466,
0.019517185,
0.0182481,
0.029068716,
-0.010860692,
-0.013919854,
-0.009264317,
0.010072524,
-0.004451815,
-0.021013368,
-0.016858786,
-0.00067461864,
0.0107671805,
-0.0032010986,
-0.0063253846,
-0.016658405,
-0.013038173,
0.01616413,
0.012250005,
-0.0320878,
0.0062585906,
-0.0029739994,
0.00802195,
0.0116889365,
-0.021080162,
-0.007748095,
0.016912222,
0.022937033,
-0.0011705635,
-0.010413173,
0.03430536,
0.010720424,
-0.0301107,
-0.017727107,
-0.03462597,
-0.014788175,
0.020091612,
0.0424275,
0.0023995717,
0.020078253,
-0.004318227,
-0.0023895525,
-0.027385509,
0.0144675635,
0.011942754,
-0.021480925,
0.0070467587,
0.024740469,
-0.03735116,
-0.0045319675,
0.021160316,
0.03748475,
0.0033547247,
0.0063153654,
-0.008168897,
0.011722334,
-0.03473284,
-0.026543904,
-0.0059212814,
-0.016791992,
0.021788178,
0.025956118,
-0.017232832,
0.015843518,
-0.047797732,
0.010032447,
0.033049632,
-0.013973288,
0.015883595,
0.0206794,
0.002209209,
0.010580158,
0.0034332077,
0.034679405,
-0.0032729022,
-0.0090438975,
-0.013826342,
0.0025248104,
-0.013178441,
0.0017316325,
0.007935118,
0.008957065,
-0.014494281,
0.0061584,
-0.02405917,
-0.010072524,
-0.012056303,
0.034332078,
0.022509553,
-0.0013943232,
0.0013509071,
0.015562984,
0.016484741,
0.004114506,
-0.010292944,
-0.01516222,
-0.0063020065,
-0.008249049,
0.019637413,
-0.0439504,
-0.63737434,
-0.019877871,
0.047797732,
-0.003473284,
0.0030708506,
0.030564899,
-0.00060865964,
-0.012991418,
-0.02957635,
0.012523861,
-0.023311079,
0.026343523,
0.011294852,
-0.004765746,
0.0019069666,
-0.033557266,
0.00933779,
-0.013759548,
0.026877875,
0.005927961,
-0.0018769093,
-0.0014101868,
0.013592564,
0.019583978,
0.0063454225,
0.008095424,
0.029977113,
-0.04178628,
-0.009865463,
0.0071269115,
-0.007981874,
0.026784362,
-0.013438937,
-0.005901243,
0.054984756,
0.0072471406,
0.007554393,
0.02462024,
0.008416034,
0.029763373,
0.00538693,
0.0027084935,
0.031419862,
-0.023551537,
0.005129773,
0.01715268,
-0.005981396,
0.003364744,
0.04141223,
-0.032354977,
0.009838745,
-0.0020205162,
-0.016778633,
0.006405537,
0.02715841,
-0.004749048,
0.041038185,
0.0005806897,
0.027519096,
-0.0013266943,
-0.0066760527,
0.027545813,
-0.007080156,
0.001990459,
0.0066226176,
0.0018869283,
-0.0045687044,
0.0048759566,
-0.010927486,
0.0014352344,
0.0044451356,
0.03342368,
-0.022215659,
0.016845427,
0.012463746,
0.030244289,
-0.015763367,
-0.0017316325,
-0.0055305366,
-0.008188935,
-0.009050577,
-0.0037771964,
-0.011488555,
0.0079084,
0.014173671,
-0.006986644,
-0.012483784,
0.020492375,
-0.021000009,
0.023217568,
0.014213746,
0.0084494315,
-0.0070334002,
-0.03219467,
-0.0131918,
0.009304393,
-0.020091612,
0.0018435123,
0.023925584,
-0.013719472,
-0.011916036,
-0.009952295,
0.008202294,
0.0003130965,
0.026824439,
0.021374056,
-0.04352292,
-0.0028988563,
0.035400778,
-0.010025768,
-0.010119279,
0.0036235703,
-0.00956489,
-0.00025089466,
0.007607828,
-0.008135499,
0.0052700406,
0.0033897916,
0.00022334218,
-0.007828248,
0.01858207,
-0.0024897435,
0.0112280585,
-0.012343517,
0.0045987614,
0.019437032,
0.0011396713,
-0.01461451,
0.007507637,
-0.018849244,
0.003757158,
-0.013585884,
-0.0052065863,
-0.011769089,
0.028106883,
-0.008516225,
0.027759554,
-0.0025014323,
0.0028454212,
-0.022282453,
-0.01022615,
-0.016765274,
0.004385021,
0.0017817279,
-0.012229967,
-0.0018368328,
-0.013098288,
-0.010072524,
0.015095427,
-0.0013049863,
0.009958974,
0.01297138,
-0.026450394,
0.019704208,
0.009204202,
-0.003099238,
-0.02121375,
-0.018969474,
-0.004164601,
0.007026721,
0.011608784,
0.036469482,
0.009812027,
0.015709931,
-0.026356881,
-0.010152676,
-0.0006366296,
0.019717567,
-0.01925001,
-0.026116423,
0.0032344956,
-0.0048125023,
0.00615506,
0.0085229045,
0.007828248,
0.0060181324,
-0.0011630491,
-0.024312988,
0.0008290796,
-0.021961842,
-0.011294852,
-0.010740463,
-0.0091774855,
-0.013458976,
0.030083982,
-0.0065458044,
0.025208026,
-0.00812882,
0.014721381,
0.039942767,
-0.011595425,
0.012624051,
-0.022349246,
0.02385879,
-0.0020305354,
-0.015175579,
0.034866426,
0.028721387,
0.0067061097,
0.03099238,
-0.0075209956,
-0.028427493,
0.025889324,
-0.017232832,
0.018395046,
-0.04715651,
0.013612602,
-0.008836836,
0.00089587347,
0.00085037015,
-0.0042247158,
0.011969471,
0.014520999,
0.009518134,
-0.0085229045,
0.013812983,
0.017406497,
-0.011421761,
0.00033543073,
-0.0054670824,
-0.0052333036,
0.020933215,
0.016351152,
-0.017887414,
0.0019086363,
0.021293903,
0.020278635,
-0.0047958037,
-0.003703723,
-0.021013368,
-0.005814411,
-0.015402678,
-0.0012765989,
0.016431306,
-0.007955156,
0.02089314,
-0.008309164,
-0.006322045,
0.016765274,
-0.0006441439,
-0.0044551548,
0.008783401,
0.004184639,
0.0063053463,
-0.0041211853,
-0.008195614,
0.02890841,
-0.013378823,
-0.01616413,
0.031419862,
-0.016698482,
0.0050529605,
0.019303443,
0.0019604017,
-0.012383593,
0.007527675,
0.01990459,
-0.012958021,
0.037564903,
0.02033207,
0.024459934,
-0.010687028,
-0.017793901,
-0.008562981,
-0.004097807,
0.021160316,
-0.0140668005,
-0.0054604034,
-0.00020956593,
-0.0055138385,
-0.031820625,
0.0076145073,
0.022496194,
-0.03232826,
0.027839707,
0.020786269,
0.00026174868,
0.0132786315,
0.017793901,
0.00835592,
-0.026356881,
-0.04277483,
0.019169856,
0.020933215,
-0.018942757,
0.0050863572,
-0.008977103,
0.0079284385,
0.007834927,
0.0028387418,
0.015175579,
0.0052500023,
0.006135022,
-0.002449667,
-0.011281494,
-0.0075209956,
0.030484747,
-0.009411264,
-0.0025999534,
-0.02177482,
-0.0020171765,
0.0039942767,
-0.007828248,
0.015803441,
0.027866425,
0.019971384,
-0.0064656516,
-0.005079678,
-0.00802195,
-0.017072527,
0.011107829,
-0.007888363,
0.013759548,
-0.012497143,
0.008696569,
-0.005834449,
-0.022215659,
-0.0001830571,
0.011882639,
0.008102103,
-0.01912978,
-0.03206108,
0.014761457,
-0.0019487127,
0.01989123,
0.0058411285,
-0.008703249,
0.022309171,
0.0008111287,
0.009404585,
-0.021734742,
-0.042507652,
0.02363169,
0.0011054394,
-0.0389275,
0.01745993,
0.016698482,
0.0010745472,
0.026396958,
0.023137415,
0.0070467587,
-0.005694182,
-0.018849244,
-0.012510502,
-0.0009409594,
-0.0045820633,
0.0259294,
0.015629778,
0.017085886,
-0.026076347,
0.014440846,
0.019183215,
-0.0031610224,
-0.017486649,
0.008068706,
0.02176146,
0.00095264835,
0.016751915,
-0.013505731,
-0.02154772,
0.0020054874,
0.039194673,
0.0024045813,
-0.002264314,
0.020906499,
0.021627873,
0.017339703,
-0.0153893195,
-0.015910313,
-0.01758016,
0.004572044,
0.0013509071,
-0.008001912,
-0.01879581,
0.018969474,
-0.031206122,
-0.0069666062,
-0.023524819,
0.0061717583,
0.027185127,
-0.0025081118,
-0.012163173,
0.0091774855,
-0.019196574,
-0.00013932795,
-0.007013362,
-0.022001918,
-0.0054036286,
-0.025461843,
-0.013138365,
0.029389326,
0.0076879803,
-0.023805354,
-0.0261565,
0.028187035,
-0.03353055,
-0.018769093,
0.023097338,
0.010740463,
0.025782455,
0.008950385,
-0.005263361,
0.019664131,
0.032729022,
-0.00058528176,
-0.018501917,
-0.0020505735,
-0.024606882,
0.024232835,
0.01989123,
0.022937033,
-0.015202297,
-0.015041991,
0.013679395,
0.005750957,
-0.012517181,
0.026236653,
0.0094446605,
-0.011582066,
-0.008148858,
0.020839704,
0.027625967,
-0.028507646,
-0.017272908,
-0.02141413,
-0.016444664,
-0.026664134,
-0.01890268,
-0.009938936,
-0.01946375,
0.00450525,
-0.002187501,
-0.01637787,
-0.015469473,
-0.0057843537,
0.017887414,
-0.0038406507,
-0.000620766,
0.0063688005,
0.016511457,
0.0030357838,
-0.009738554,
-0.011515273,
-0.00373712,
-0.012036265,
-0.039755743,
0.018541994,
0.019503826,
-0.017566802,
0.017192755,
-0.0062452317,
-0.013345426,
-0.008202294,
0.0006570852,
0.0018986173,
0.029923677,
0.022896957,
-0.016110694,
-0.02177482,
-0.0021056784,
-0.005333495,
0.0068396977,
0.0059379796,
-0.018742375,
-0.0042681317,
0.024366423,
-0.01759352,
-0.0059613576,
0.044992387,
-0.03516032,
-0.005360212,
0.03462597,
-0.012717563,
0.015776725,
-0.004518609,
-0.004354964,
-0.013125006,
0.0002254295,
-0.012477105,
-0.029282456,
0.0070734764,
-0.020933215,
0.030404594,
0.04469849,
0.030030549,
-0.0047724256,
0.025475202,
0.033156503,
0.0053167962,
0.008883592,
0.013973288,
0.021748101,
-0.00802195,
-0.0050596395,
-0.00033605692,
-0.0048659374,
0.033984747,
-0.017673671,
0.0073005757,
0.019877871,
-0.011702295,
-0.015870236,
0.019944666,
-0.039969485,
-0.0063721403,
0.028748104,
0.0010545091,
0.023658408,
-0.017767183,
-0.0024880737,
0.023671767,
-0.0013208499,
0.004762407,
0.005360212,
0.02989696,
-0.010166035,
0.024112606,
-0.0034131694,
0.006986644,
0.00018963212,
-0.01955726,
0.0051832083,
-0.011956112,
0.018208023,
0.008429393,
-0.01572329,
0.002848761,
-0.00055313716,
0.011855922,
-0.0008136335,
-0.013599243,
-0.017713748,
-0.034599252,
-0.025742378,
-0.023898866,
-0.030645052,
-0.044458035,
-0.018221382,
0.009137409,
0.011020998,
-0.016551534,
0.01593703,
-0.019062985,
-0.03438551,
0.021814896,
-0.021534361,
0.020345429,
-0.0012482115,
0.009551531,
0.036469482,
-0.004739029,
-0.019370237,
-0.002286022,
0.019477108,
-0.004031013,
0.0069732857,
0.0075477134,
-0.002735211,
-0.020318711,
0.016564893,
-0.008649813,
-0.015015274,
-0.033343527,
0.010493325,
-0.0039508604,
0.011815845,
-0.0062619303,
-0.025101157,
-0.020305352,
0.015349244,
-0.0204523,
-0.0030541522,
-0.022790087,
-0.006221854,
-0.008249049,
-0.0021691327,
-0.023030546,
0.0051798685,
-0.010059165,
-0.023043903,
-0.012256685,
-0.031820625,
-0.0077080186,
-0.0052833995,
0.025368333,
0.016270999,
0.0031860701,
0.02922902,
-0.0031810605,
-0.022456117,
0.009217561,
-0.0069666062,
-0.023885507,
0.042480934,
-0.022482835,
-0.0025198008,
-0.007487599,
-0.011628822,
-0.013305349,
-0.0031493334,
-0.0054036286,
0.017513366,
-0.017620238,
-0.006088266,
0.02671757,
-0.005877865,
-0.040423684,
0.0019386936,
-0.024339706,
-0.003977578,
-0.008429393,
-0.009972333,
0.008556302,
-0.022148864,
0.030404594,
0.005320136,
-0.022522911,
-0.005343514,
0.011548669,
0.0027669382,
-0.010506684,
0.039755743,
-0.012477105,
0.015977107,
0.0025114515,
0.022389323,
-0.0024112607,
0.0056507657,
-0.0075744307,
-0.013893136,
0.01911642,
-0.0020372146,
-0.03438551,
-0.011662219,
0.014280541,
0.009224241,
-0.017753825,
-0.006933209,
0.021160316,
0.0066760527,
0.014414129,
-0.0031844003,
-0.000857467,
0.020839704,
-0.011835883,
-0.0061383615,
0.016311076,
-0.012002868,
-0.0051264334,
0.0101126,
-0.00999905,
0.012503822,
-0.0068196594,
-0.0051798685,
-0.02075955,
0.010813937,
-0.0224294,
-0.0037838758,
-0.008950385,
-0.014895045,
-0.015229015,
0.025488561,
0.0048392196,
-0.01671184,
-0.014253823,
0.011622143,
-0.027786272,
0.009825386,
-0.019410314,
0.020839704,
0.025461843,
-0.007921759,
-0.026864516,
0.004308208,
-0.020839704,
0.05111071,
0.011735693,
-0.00648235,
-0.012123097,
0.0061483807,
-0.02912215,
-0.015896954,
-0.0036502879,
-0.008382637,
-0.002770278,
0.027104974,
-0.005944659,
-0.013946571,
0.003506681,
0.015643137,
-0.009758593,
-0.043255746,
-0.020131689,
0.0143339755,
0.009852104,
0.011074432,
-0.030858792,
-0.03262215,
0.0064021973,
-0.0023928923,
-0.019704208,
0.02922902,
-0.026557263,
0.027866425,
-0.009511455,
0.009351149,
-0.011308211,
0.015068709,
-0.0040844483,
-0.004815842,
0.0058311094,
-0.0044484753,
-0.008970424,
-0.0045419866,
0.005213266,
-0.0056808232,
0.014494281,
-0.00064456137,
-0.021253826,
0.0068096407,
-0.0024580164,
-0.007748095,
0.041919865,
0.020385506,
-0.009250958,
0.012143135,
-0.004782445,
-0.010640272,
-0.010727104,
-0.0023561555,
-0.0059747165,
0.025475202,
-0.018782452,
-0.0056374073,
-0.01595039,
0.011695616,
0.010212791,
-0.038393147,
0.01505535,
-0.0029372629,
0.010833974,
-0.04285498,
0.008916989,
0.0002160366,
-0.0066025793,
0.014053442,
-0.010727104,
-0.020585887,
-0.016898863,
-0.0026550584,
-0.00059404847,
-0.008102103,
-0.013231876,
-0.00857634,
-0.008716607,
0.0013926533,
-0.007741416,
-0.015656495,
-0.03230154,
0.0010428202,
0.18926726,
-0.011014318,
-0.005857827,
0.00801527,
-0.0015295808,
-0.0106335925,
0.003857349,
-0.014360693,
-0.021694666,
0.022456117,
0.004274811,
-0.014240464,
-0.027572531,
0.0044918912,
0.0037437994,
-0.024807263,
-0.024780545,
0.014133594,
-0.017740466,
-0.0042848303,
0.033904597,
-0.0091774855,
0.009090653,
0.005470422,
0.04696949,
0.006979965,
-0.00012075089,
-0.00095014356,
0.009197523,
-0.00069632666,
-0.04803819,
0.018301535,
-0.002680106,
-0.009591607,
-0.032167953,
0.010206112,
-0.048091624,
0.011248097,
0.032942764,
0.012844471,
0.008142179,
-0.013104968,
0.0022726632,
-0.004535307,
0.008830156,
0.021160316,
0.007794851,
-0.020719474,
-0.013973288,
-0.0010503344,
-0.031954214,
0.016538175,
0.011608784,
0.016124053,
0.00747424,
0.0079084,
0.024700392,
0.00395754,
0.010606875,
0.012824433,
-0.0046321587,
0.008870233,
-0.044912234,
0.034465663,
-0.000043546508,
0.035213757,
-0.007340652,
-0.00967176,
0.000588204,
-0.03491986,
0.0022058694,
-0.01231012,
0.0022626442,
0.0011605445,
0.0047958037,
-0.021534361,
0.014895045,
-0.001275764,
-0.00912405,
0.014761457,
0.001516222,
0.010593516,
-0.030351158,
0.010192753,
-0.012276723,
-0.015282449,
0.025956118,
0.015095427,
-0.016137412,
-0.009618325,
-0.0007376554,
-0.01484161,
0.0018802489,
-0.011481876,
-0.005253342,
-0.013572525,
0.022162223,
0.0075009577,
-0.010613554,
-0.0004604606,
0.005290079,
0.047530554,
0.0149885565,
0.019637413,
-0.0054336856,
0.017232832,
0.007995233,
0.009157447,
-0.006662694,
-0.011047715,
0.0120897,
-0.032942764,
0.002057253,
-0.0057776743,
-0.008476149,
0.029736655,
-0.0024396481,
-0.011468517,
0.016137412,
0.009625005,
-0.008416034,
-0.009037218,
-0.011441799,
0.020078253,
-0.0038072537,
-0.005657445,
-0.04341605,
0.020505734,
-0.016017184,
-0.024473293,
-0.012169853,
-0.010840653,
-0.013906495,
0.020959932,
0.014961839,
-0.0068998123,
0.0011238077,
-0.028320624,
-0.021480925,
0.019690849,
-0.0010703726,
-0.012911266,
0.01022615,
-0.0058645066,
0.009003821,
-0.004739029,
0.016538175,
0.023257645,
-0.012657449,
0.00802195,
-0.010760501,
-0.013619281,
-0.030938946,
-0.022148864,
0.0062485714,
-0.020064894,
-0.019570619,
-0.00626527,
-0.0031292953,
0.014253823,
-0.037217572,
0.01955726,
0.005924621,
0.009952295,
-0.011254776,
0.0010027437,
-0.16821381,
0.004331586,
0.018982833,
-0.02989696,
0.016204206,
0.0053468538,
0.013392181,
0.005573953,
-0.013345426,
0.005560594,
0.048786283,
-0.018288177,
-0.013565846,
-0.008048668,
0.0034599253,
-0.009277676,
-0.047557272,
0.04825193,
0.019597337,
0.020398865,
0.02232253,
-0.019423673,
0.022950392,
-0.02550192,
-0.001671518,
0.017112603,
0.021347338,
0.004371662,
0.013499052,
-0.023257645,
-0.012978059,
0.001990459,
0.058297735,
0.011922715,
0.022335887,
-0.0027719478,
-0.008703249,
-0.010005729,
0.0026366902,
0.01725955,
0.026530547,
0.007728057,
0.021053445,
0.0022676536,
-0.032167953,
0.050416052,
-0.0050195633,
-0.0032996198,
0.026263371,
0.0029305834,
0.010059165,
0.0022225678,
-0.0030591616,
0.020746192,
0.010840653,
0.004187979,
0.007607828,
0.020786269,
-0.0064088767,
0.014868327,
-0.010833974,
-0.019730926,
0.030645052,
0.00022814299,
0.019223291,
-0.02285688,
-0.012797716,
0.013659357,
0.002043894,
0.00549714,
-0.008836836,
-0.00016374947,
0.020612605,
0.0008499527,
0.008202294,
0.018007642,
-0.008275767,
0.018074436,
0.007861645,
-0.019383596,
-0.010045806,
0.0006195136,
-0.01583016,
0.0037504788,
-0.016364511,
0.01615077,
0.002803675,
0.021173673,
-0.022362605,
0.007634545,
0.008162217,
-0.02989696,
-0.021026727,
-0.0049761473,
-0.0070601176,
0.030698488,
-0.012897907,
-0.009751913,
0.0015045331,
-0.0015112126,
0.0066760527,
-0.023324437,
-0.0010570139,
-0.008496187,
-0.004344945,
-0.009484737,
-0.024166042,
0.004221376,
0.038286276,
-0.013706113,
0.00923092,
0.0045419866,
-0.0008365939,
0.027438944,
-0.016070617,
0.010386455,
-0.0037604978,
0.00088418456,
0.011348288,
-0.027412226,
0.06877102,
0.00835592,
0.033236656,
0.018715657,
0.0006015628,
-0.023524819,
-0.12696189,
-0.04672903,
0.014681304,
-0.0056507657,
-0.030164136,
0.006499049,
-0.009544851,
0.036870245,
-0.037271008,
0.013044853,
-0.01803436,
-0.005740938,
-0.018408405,
-0.026410317,
-0.012129776,
-0.018061077,
0.0027302017,
-0.009785309,
-0.036442764,
0.013378823,
-0.005550575,
-0.013111647,
0.018528635,
-0.0023661747,
0.004388361,
-0.0060949456,
-0.022723293,
0.03318322,
-0.0053401743,
0.008395996,
-0.0219752,
0.009264317,
-0.0011897668,
-0.011354967,
-0.013245235,
0.0048191817,
0.007888363,
-0.00046922732,
0.041572537,
0.01745993,
-0.011181302,
0.00068630755,
0.015910313,
0.022896957,
-0.016778633,
-0.009204202,
-0.016658405,
-0.0063821594,
0.010353058,
-0.008736645,
-0.030351158,
-0.018875962,
-0.039889332,
-0.006933209,
0.012437029,
0.0070601176,
0.017606879,
0.012296761,
0.0063287243,
-0.014774816,
0.042507652,
0.010259546,
0.0055572544,
0.006495709,
0.02186833,
-0.014761457,
-0.0032294863,
-0.03606872,
0.016765274,
-0.033824444,
-0.0053000976,
-0.010186073,
0.0024697054,
-0.019931307,
-0.019864513,
0.008041988,
-0.022496194,
-0.027599249,
0.007173667,
-0.01858207,
-0.01990459,
0.0009943945,
0.036442764,
-0.024874058,
0.025702301,
0.0032812515,
0.0045987614,
-0.019103061,
-0.0064489534,
-0.010573478,
-0.021908406,
0.031152686,
0.013532449,
-0.0028738086,
-0.016297717,
0.012724242,
0.00219919,
0.009631684,
0.016137412,
0.025822531,
-0.016003825,
-0.025208026,
-0.047530554,
0.010085883,
-0.008402675,
0.015095427,
0.006756205,
0.004428437,
0.02791986,
-0.017606879,
0.0021407453,
0.009104012,
0.006619278,
0.010085883,
-0.0048792963,
0.027465662,
-0.012710883,
-0.03868704,
0.0105000045,
-0.00065792014,
0.016083976,
0.03045803,
0.0144675635,
0.014748098,
0.0075009577,
0.038152687,
0.0026016233,
-0.0056507657,
-0.022349246,
0.0336107,
0.0071937055,
0.0061517204,
-0.0026099726,
-0.037431315,
-0.019316802,
0.00681298,
-0.016217565,
-0.00056440866,
0.017874055,
0.028641235,
0.02515459,
0.018395046,
-0.022469476,
-0.04012979,
0.020385506,
-0.0130114565,
-0.014721381,
0.0003258291,
-0.059419874,
0.009591607,
0.03286261,
-0.0038807269,
0.036736656,
0.009598287,
-0.0016731878,
-0.02901528,
-0.028988563,
-0.009464699,
0.013599243,
-0.019944666,
-0.019570619,
-0.0077748126,
0.012169853,
0.004278151,
0.0034432267,
-0.0051631704,
0.007941797,
-0.015322526,
-0.025194667,
0.006859736,
0.0011997859,
0.010934165,
-0.030164136,
0.02516795,
0.0012348527,
-0.0017917469,
0.028106883,
-0.0007130251,
-0.010586836,
0.013839701,
-0.0030508125,
0.012356875,
0.0100391265,
-0.011334929,
-0.0219752,
0.022362605,
0.042347346,
-0.008977103,
-0.030725205,
-0.0002208374,
0.008589699,
-0.012931303,
0.0071536293,
0.018101154,
-0.019490467,
0.013893136,
0.005156491,
0.012343517,
0.001000239,
-0.009491417,
-0.016738556,
0.047744296,
0.018061077,
0.002736881,
-0.004999525,
-0.017967565,
-0.028667951,
0.033984747,
-0.034278642,
-0.032248106,
-0.02328436,
-0.010733783,
0.0056374073,
0.0011020998,
-0.0036736657,
0.0030073964,
-0.020198483,
0.015696572,
-0.019610696,
0.0036803451,
-0.017526725,
0.0054370253,
0.006285308,
0.009304393,
-0.016698482,
-0.011067753,
-0.007768133,
0.00024108432,
0.011114509,
-0.050068725,
0.011047715,
-0.026530547,
0.03264887,
-0.00052349735,
-0.0364962,
-0.00868321,
-0.027545813,
-0.016498098,
0.016177488,
0.03956872,
-0.053488575,
0.071923696,
-0.0003156013,
-0.009691798,
-0.008382637,
-0.009812027,
0.0031443238,
0.0010937505,
0.016070617,
-0.004344945,
-0.016124053,
0.023030546,
-0.026824439,
0.037137423,
-0.028507646,
-0.03617559,
0.021921765,
-0.011782448,
0.0074141254,
0.012517181,
-0.0067996215,
0.013044853,
-0.0109608825,
0.012737601,
-0.0046755746,
-0.05054964,
-0.018715657,
0.021828255,
-0.0078549655,
-0.011608784,
-0.02495421,
0.011628822,
-0.009217561,
-0.040423684,
-0.009104012,
0.007080156,
-0.011862601,
-0.00070718065,
-0.033156503,
-0.0045954217,
-0.00014120653,
-0.007888363,
0.052072544,
-0.025421767,
-0.018875962,
-0.0043482846,
-0.02594276,
-0.0132652735,
-0.00879676,
-0.014000006
] |
Legionella pneumophila, the causative agent of Legionnaires' pneumonia, resides in a distinct vacuole structure called Legionella-containing vacuole (LCV). The LCV resists fusion with the lysosome and permits efficient bacterial replication in host macrophages, which requires a Dot/Icm type IVB secretion system. Dot/Icm-translocated effector SdhA is critical for L. pneumophila intracellular growth and functions to prevent host cell death. Here, we show that the absence of SdhA resulted in elevated caspase-1 activation and IL-1β secretion as well as macro
|
[
-0.0011033507,
0.015880188,
0.016431024,
-0.020985493,
-0.022221515,
0.03458173,
-0.019615123,
-0.010177024,
-0.00054537767,
0.014818822,
0.024827909,
0.013562648,
0.015880188,
0.027676132,
0.021872206,
-0.004719049,
0.02563401,
-0.014294856,
0.0103852665,
-0.020085348,
-0.00061633135,
0.0026231867,
0.015826449,
-0.0018909784,
0.01751926,
-0.0098277135,
0.0022923495,
-0.025459355,
-0.0103852665,
0.011574266,
0.0014056385,
-0.0016986898,
-0.032432128,
0.015329353,
-0.012400519,
-0.020569008,
0.013945546,
-0.010519617,
0.012622197,
-0.0033671507,
0.018204445,
0.019118028,
-0.0058207205,
0.003970047,
-0.007268343,
0.022369301,
-0.004786224,
0.011386176,
-0.023766542,
-0.0065428526,
0.019709168,
-0.01746552,
-0.031733505,
0.0008699173,
-0.018929936,
-0.017573,
0.0048802695,
-0.0055184327,
0.025728054,
-0.053551972,
-0.012602044,
-0.0078930715,
-0.04191725,
0.018929936,
-0.007449716,
0.012736395,
0.011748921,
0.018271621,
0.015826449,
0.0034460814,
0.056964464,
0.032942656,
0.023833718,
0.0105330525,
0.02185877,
-0.039418336,
-0.03519974,
0.015651792,
-0.0028331089,
0.013246926,
0.00886711,
-0.01854032,
-0.026802856,
0.010297939,
0.023336621,
-0.0068384227,
0.0067914003,
0.019467337,
-0.021039234,
-0.016498199,
0.0006956819,
0.012675937,
0.00859841,
0.019655427,
-0.0061431606,
0.018607497,
0.00902833,
0.020165958,
0.013683563,
-0.0258221,
-0.021361675,
0.013649976,
-0.041648548,
-0.021899074,
-0.017425215,
-0.0020908243,
0.010539769,
-0.0021764725,
0.022087166,
0.015718969,
-0.028106052,
0.039552685,
-0.016323544,
-0.062016033,
0.031760376,
-0.023941198,
0.012803569,
0.0018456352,
0.0002980894,
-0.021899074,
0.016914684,
0.019158332,
0.014415772,
-0.013193185,
0.03229778,
-0.0004945765,
-0.014173942,
-0.013058835,
-0.007060101,
-0.00070030015,
-0.0089342855,
0.026601331,
0.014388901,
-0.015987668,
-0.007879636,
-0.0051791985,
-0.010391984,
-0.019373292,
-0.023806848,
-0.008370015,
0.006126367,
0.033184487,
-0.015195003,
0.00910894,
0.012198994,
0.012319909,
0.028132923,
0.0075370437,
-0.0026030343,
0.021482589,
0.009061918,
-0.030363135,
-0.009263443,
-0.022664871,
0.00009037147,
0.026265455,
-0.022920135,
0.047156904,
-0.015087523,
-0.031411067,
-0.03745682,
0.015127827,
0.0046485155,
0.013891806,
0.032781437,
0.02134824,
0.020004738,
-0.010203894,
-0.0044134026,
-0.001350219,
-0.0022554032,
0.013602953,
-0.025204089,
0.031088626,
-0.009968782,
0.032727696,
0.03630141,
-0.012581892,
-0.013011812,
-0.009619471,
0.009639624,
0.032163426,
0.027514912,
0.007725134,
-0.020501833,
-0.011715333,
0.027864221,
-0.009565731,
0.023094792,
-0.023578452,
-0.0035703552,
0.009303749,
-0.0071272757,
-0.019023981,
-0.6169359,
-0.03208282,
-0.0036207368,
0.005044848,
-0.014254551,
0.007422846,
-0.01644446,
-0.015208437,
-0.024760734,
0.024088982,
-0.015611487,
0.011755639,
0.009229856,
-0.011755639,
0.004749278,
-0.015933929,
0.0049709557,
0.007913224,
0.013958981,
-0.006673844,
-0.017505825,
-0.0014568595,
-0.019359857,
0.013811196,
-0.0010504503,
0.025459355,
0.04487295,
0.007792309,
0.00061255274,
0.023833718,
-0.014402336,
0.016699724,
-0.023188837,
-0.009841149,
0.04645828,
0.015168132,
-0.020125654,
0.03345319,
0.013320818,
0.027971702,
-0.020851145,
-0.0105330525,
0.00859841,
-0.0033654713,
-0.018096967,
0.012628915,
0.0023494484,
0.029745124,
-0.007725134,
-0.019037416,
0.031679768,
-0.010593509,
-0.006646974,
0.02215434,
0.012689372,
0.008067727,
0.019400163,
-0.02654759,
0.011990751,
0.019682297,
-0.003002726,
0.019574817,
-0.01086221,
-0.011641441,
-0.0070197955,
-0.017210254,
-0.019467337,
0.0021630374,
0.009290313,
-0.010163589,
0.005515074,
0.02231556,
0.0021227323,
0.021925945,
-0.0012704487,
0.029583903,
-0.018083531,
0.022987312,
-0.015127827,
0.015624923,
-0.0065025473,
-0.019870387,
-0.023981502,
-0.010237481,
0.026507284,
0.007678111,
-0.0031387554,
0.028535973,
-0.0023259372,
-0.011278695,
0.02113328,
0.035925232,
-0.0043193577,
-0.031061755,
-0.04253526,
0.021106409,
-0.0017347963,
0.0008199558,
-0.010391984,
-0.022221515,
-0.017049035,
-0.024142724,
0.021845335,
-0.026023624,
0.031303585,
0.014227681,
-0.009679928,
0.0071339933,
0.029583903,
-0.030766185,
0.011560831,
-0.015396528,
-0.0071004056,
-0.022570826,
-0.009189551,
-0.03431303,
0.031948466,
0.03388311,
0.012702807,
-0.039364595,
0.028025443,
-0.018553756,
0.006623463,
-0.009975499,
-0.0207571,
0.016068278,
0.022772351,
-0.031679768,
-0.02145572,
-0.0024166233,
0.0078057437,
0.001835559,
0.029315203,
-0.022181211,
0.024156157,
0.037671782,
0.024518903,
0.007322083,
0.013448451,
-0.02105267,
-0.017049035,
-0.012017622,
0.0034561576,
-0.012555022,
-0.020286873,
-0.011278695,
-0.019359857,
-0.016645985,
-0.003630813,
-0.013092423,
0.011675028,
-0.006919033,
-0.00040850844,
0.012387084,
0.009431381,
-0.025808664,
-0.02705812,
-0.0059080482,
-0.0017138042,
-0.019628558,
0.015584618,
-0.012958072,
-0.0005285839,
-0.0011092285,
-0.009014895,
-0.014912867,
0.025419049,
-0.014899432,
0.0047660717,
-0.027998572,
0.014630732,
0.00811475,
-0.030981146,
0.020031609,
0.008551387,
0.01604141,
-0.0064924713,
-0.0016164003,
0.0013703716,
-0.0025291417,
0.013670128,
-0.029046504,
0.009236573,
0.01854032,
0.0067510954,
0.012763265,
0.036704462,
-0.003912948,
0.009626188,
0.024102418,
-0.004786224,
0.004171572,
-0.00066671264,
0.0044234786,
0.006129726,
0.00420516,
0.021079538,
0.009229856,
0.0130454,
0.017855136,
-0.018822456,
-0.011191368,
-0.0021361674,
-0.039445207,
0.02054214,
-0.029691383,
-0.00636148,
-0.011547396,
0.032620218,
0.025325004,
0.01107717,
0.004994467,
-0.011842966,
0.0003020779,
0.0056729354,
0.030148175,
0.033211358,
-0.012917767,
-0.015651792,
0.010190459,
-0.008531235,
0.005814003,
0.011762356,
-0.0071004056,
-0.022087166,
-0.022436475,
0.010828623,
0.015302483,
-0.0332651,
-0.016242934,
-0.002843185,
0.019050851,
0.020313744,
0.015893623,
0.00816849,
0.024115853,
0.0021462438,
0.005377365,
0.023685932,
-0.00077965076,
-0.020636184,
0.00910894,
0.0070197955,
-0.012702807,
0.0032714263,
0.017787961,
0.014724777,
0.013408145,
-0.022879831,
-0.00006843461,
-0.008484213,
-0.022664871,
-0.021388544,
0.0040137107,
-0.018083531,
-0.014093331,
-0.0005088512,
0.011648159,
0.037967354,
0.010492747,
-0.0051388936,
-0.030739315,
0.003064863,
-0.023256011,
0.012440824,
-0.0058878954,
-0.010076261,
-0.005075077,
-0.007288496,
0.011204802,
-0.028535973,
0.0066939965,
0.013414863,
-0.020125654,
0.013280513,
0.001996779,
-0.019830083,
-0.0062842285,
-0.0027021174,
0.0015223551,
-0.008719325,
-0.027676132,
0.015665228,
0.015933929,
0.0074026934,
-0.0061633135,
-0.04369067,
0.014724777,
-0.01671316,
0.038182314,
0.009122375,
0.012702807,
0.009894889,
0.018983677,
-0.0050314134,
0.0007695745,
-0.004735843,
-0.02536531,
0.0016634228,
0.023968067,
-0.012588609,
0.0012259452,
-0.011869836,
-0.007053383,
0.031142365,
0.00056636985,
0.0022033425,
-0.0036677592,
-0.0029036426,
-0.002700438,
-0.010096414,
0.0016424307,
-0.005800568,
-0.00092449697,
-0.0021764725,
0.0011764035,
-0.024518903,
0.0113324355,
0.03528035,
0.0006180107,
-0.009424663,
-0.050166346,
0.0007678951,
-0.027219342,
0.015477138,
0.027273081,
-0.029127114,
0.011923576,
-0.006455525,
-0.0025509736,
-0.0043999674,
-0.018755281,
0.029422684,
0.0013073949,
-0.0049877493,
0.0035535616,
0.023954632,
0.016686289,
0.020246569,
0.030363135,
0.01733117,
-0.01288418,
-0.013213337,
0.010828623,
0.005894613,
-0.013273795,
0.020098783,
0.019803213,
-0.0026668506,
-0.013112575,
0.0011327397,
-0.0009857942,
-0.0035804317,
-0.0038961545,
-0.013643258,
0.011896706,
0.011701899,
0.011755639,
-0.013105857,
-0.020851145,
-0.0105330525,
0.019346422,
-0.0035434854,
0.025607139,
0.019628558,
0.0052967547,
0.006855217,
0.029691383,
0.0016995295,
0.0071877334,
-0.0012947996,
0.012971507,
0.0051388936,
-0.013166315,
0.07765439,
-0.0009337336,
-0.012622197,
-0.036193933,
0.040358786,
-0.013797761,
-0.016780334,
-0.003466234,
-0.005135535,
-0.008793217,
-0.011204802,
-0.034366768,
0.0020051762,
-0.0028969252,
-0.01711621,
0.0028448645,
-0.0046485155,
0.0111846505,
-0.028885283,
-0.021979686,
-0.009646341,
-0.026896901,
-0.014576992,
-0.00091190165,
0.023565017,
0.011359305,
0.010042674,
-0.002196625,
-0.001153732,
-0.008370015,
-0.012078078,
-0.010553204,
-0.006905598,
-0.053417623,
0.009538861,
0.016216064,
0.009377641,
-0.004839964,
-0.020260002,
0.0077452864,
0.0348773,
-0.002468684,
0.014980042,
-0.00016888234,
-0.0066066687,
0.014294856,
0.015638357,
-0.0005382403,
-0.028132923,
-0.010351679,
0.020663053,
-0.041379847,
-0.0031757017,
-0.010062827,
0.0006482395,
-0.038397275,
-0.0091022225,
0.030013824,
-0.006808194,
0.0181104,
0.021388544,
-0.022947006,
0.00089174917,
-0.008537952,
-0.0028045594,
0.037161253,
-0.009196268,
-0.0030598247,
0.024223333,
0.0027944832,
-0.0038021093,
-0.0076378062,
0.028374752,
0.00019711687,
-0.027125295,
0.012366932,
0.023618758,
-0.01315288,
-0.012602044,
-0.0015357902,
0.008390167,
0.027917963,
0.008558105,
-0.0073489533,
-0.029825734,
-0.014509817,
0.020622749,
0.008846957,
0.009149246,
-0.04127237,
-0.002503951,
-0.0016793769,
-0.010875645,
-0.006472319,
0.0132670775,
-0.02754178,
-0.017263995,
0.0063211746,
0.013891806,
-0.004121191,
-0.0027037968,
-0.0015055614,
-0.017693914,
-0.0028902078,
-0.015826449,
-0.040143825,
-0.0070197955,
-0.011419763,
0.03229778,
-0.0029422683,
0.018755281,
-0.0009941912,
0.030739315,
0.01080847,
0.0020421224,
0.016807204,
0.0047929417,
-0.004813094,
-0.014657602,
0.031411067,
0.012743112,
0.005803927,
0.016256368,
-0.005787133,
0.01727743,
0.0088603925,
0.005333701,
-0.026668506,
-0.02536531,
-0.015571183,
-0.015315917,
-0.0010219009,
-0.015195003,
-0.019830083,
-0.036731333,
-0.011292131,
-0.0036677592,
-0.009559014,
-0.006267435,
-0.011285413,
0.014859127,
-0.020058477,
0.0062036184,
-0.005162405,
0.016216064,
0.0049877493,
0.012252734,
-0.0076243714,
0.003876002,
0.0029439477,
0.0055016386,
-0.020972058,
0.03227091,
-0.00079560484,
-0.0057031643,
0.0029641003,
-0.01107717,
-0.020327179,
-0.024115853,
-0.024612948,
-0.0348773,
-0.009572448,
-0.023779977,
-0.047559954,
0.011359305,
-0.0045779813,
0.0032898993,
0.019373292,
-0.0031572287,
-0.0151815675,
0.019265812,
0.011634723,
0.016377283,
-0.010492747,
0.026896901,
0.030309394,
-0.014671037,
-0.036355153,
0.009706799,
-0.018352231,
0.0008455663,
0.025835535,
0.031437937,
-0.019171767,
-0.020407788,
0.007422846,
0.0037886743,
0.0020068553,
-0.02638637,
0.025230959,
0.009968782,
0.009263443,
-0.009941911,
-0.024183027,
-0.015195003,
-0.002638301,
-0.021590069,
0.009800844,
-0.0059315595,
-0.005360571,
-0.015329353,
0.001800292,
0.012400519,
0.011567548,
0.0036543242,
-0.009283596,
0.004517524,
-0.023874022,
-0.0055553787,
0.020783968,
-0.02244991,
0.025378743,
0.0043092812,
0.011977316,
0.0049205744,
0.034366768,
-0.0072213206,
0.015598053,
-0.012763265,
0.037725523,
-0.016417589,
0.0019212072,
0.0057535456,
0.0049172156,
0.001040374,
-0.021254195,
-0.0038659256,
0.0004584699,
-0.0105330525,
-0.015745837,
0.028267272,
0.0001172415,
0.00017937845,
-0.012266169,
-0.023591887,
-0.0042185946,
-0.010559922,
-0.017210254,
-0.02134824,
-0.029234594,
-0.006959338,
-0.008806652,
0.0038390555,
0.013784326,
-0.0007893072,
-0.007960247,
-0.023497842,
0.028025443,
-0.010170307,
0.014590426,
0.00463508,
-0.013602953,
-0.01735804,
-0.011480221,
-0.004494013,
-0.020689923,
0.023148531,
-0.010391984,
-0.008826805,
-0.039472077,
-0.022369301,
0.023779977,
0.018903067,
-0.01347532,
0.030255655,
-0.0038961545,
0.0136768455,
-0.0051086647,
-0.001706247,
0.038907804,
-0.025177218,
0.0058576665,
0.024975693,
-0.007463151,
0.001167167,
0.0076646763,
-0.02137511,
-0.009149246,
-0.0025761642,
-0.02657446,
0.0059449943,
-0.023941198,
0.0017650252,
-0.007906507,
0.005800568,
-0.024492033,
-0.02185877,
-0.0051120236,
-0.008370015,
-0.01652507,
0.008282687,
0.0026164693,
0.0018103684,
-0.00328822,
-0.024277072,
0.0037819569,
0.015786143,
-0.024156157,
-0.017667046,
-0.0013905241,
-0.015624923,
0.035764012,
-0.013945546,
0.0048601166,
-0.0020169318,
0.012843874,
-0.062016033,
-0.008665585,
-0.018338796,
-0.0068384227,
-0.0011881592,
0.016498199,
0.003835697,
0.019843517,
-0.010748012,
0.026023624,
0.0048869867,
-0.020179393,
0.022866396,
-0.008685738,
0.020327179,
-0.0024518904,
-0.01741178,
0.003493104,
0.019171767,
0.018997112,
-0.0054378225,
0.018567191,
-0.018379102,
-0.007066818,
0.0017347963,
-0.006418579,
-0.010445724,
0.0026752474,
-0.010593509,
0.003738293,
-0.011144346,
0.0036979879,
0.009673211,
-0.010398702,
-0.000055104556,
0.004964238,
0.01716995,
0.002584561,
0.015262177,
-0.030175045,
0.00021600985,
-0.01735804,
0.026157975,
0.017505825,
0.005011261,
0.017129645,
0.0048097353,
0.0009564052,
-0.019749472,
-0.000234483,
-0.036193933,
-0.012326627,
0.009915042,
0.006875369,
-0.0081349015,
-0.006072627,
0.030551225,
-0.0075437613,
0.00038667655,
-0.0012494564,
0.00024308982,
-0.041245498,
0.030954275,
-0.0017364757,
0.0067846826,
-0.0038424144,
-0.032136556,
-0.0045779813,
-0.015826449,
0.0079669645,
0.02073023,
-0.015853317,
-0.001956474,
-0.0044805775,
-0.023538146,
-0.008282687,
-0.01794918,
0.0012351817,
0.01633698,
0.0056595,
0.18024416,
-0.015033782,
-0.005814003,
0.023887457,
-0.018809022,
-0.014885997,
-0.006919033,
-0.009868019,
0.0048265294,
0.0069526206,
0.019265812,
0.005431105,
0.010573357,
0.00555202,
0.028240403,
-0.024666687,
-0.028025443,
-0.0017104454,
-0.031787246,
-0.003916307,
-0.0005294236,
-0.003479669,
0.0052900375,
0.011695181,
0.049682688,
-0.019440467,
-0.031437937,
0.020139089,
0.009297031,
0.0091022225,
-0.017667046,
0.003110206,
0.009189551,
-0.0024115853,
0.025163785,
-0.004806377,
0.0018053302,
-0.025217524,
-0.0068686516,
0.041245498,
-0.00019690694,
0.002735705,
-0.0077116988,
-0.005800568,
-0.011151062,
0.0077116988,
-0.018997112,
-0.007147428,
-0.0047963005,
-0.009478403,
-0.064058155,
0.010257634,
-0.006687279,
0.012198994,
-0.005105306,
-0.009854584,
0.021415414,
0.019131461,
-0.012259452,
0.036167063,
-0.022570826,
0.025620574,
-0.026346065,
0.029906344,
0.018271621,
0.029960085,
-0.009720233,
0.015342788,
0.0077587212,
-0.046162713,
0.020071913,
-0.012138536,
-0.023296317,
0.0018170858,
-0.021012364,
-0.010331526,
0.028992763,
0.029825734,
0.030255655,
0.02242304,
0.0053001135,
-0.01773422,
-0.047774915,
0.010633815,
0.007725134,
-0.024760734,
0.024317378,
-0.010136719,
-0.029395813,
-0.011950446,
0.008470777,
-0.0074564335,
-0.0105330525,
0.0022671588,
0.031545416,
-0.0067175077,
-0.005787133,
-0.0057535456,
0.031679768,
-0.020448094,
-0.023645626,
0.07238787,
0.015544313,
-0.010586793,
-0.009384358,
0.008994743,
-0.006237206,
0.020327179,
0.005827438,
-0.019265812,
0.0038927956,
-0.023511278,
0.0024888366,
-0.0029960084,
0.02234243,
0.017129645,
0.020058477,
-0.029583903,
0.039364595,
-0.01056664,
-0.009579166,
-0.015020347,
0.022812657,
0.028321013,
0.0025963166,
-0.005101947,
-0.016538505,
0.036973163,
-0.016202629,
-0.036973163,
0.0054646926,
0.0210258,
-0.012790135,
0.006274152,
0.011607854,
0.018647801,
0.0024888366,
-0.004054016,
-0.0053504948,
-0.0043999674,
-0.016726594,
0.008188642,
0.04444303,
-0.00085060444,
0.006317816,
-0.015651792,
0.030631835,
0.002918757,
-0.018809022,
-0.0122997565,
-0.0018943371,
-0.02515035,
-0.009747104,
0.004487295,
0.00870589,
-0.040788706,
-0.018755281,
-0.03208282,
0.0037550868,
0.0031924956,
-0.015208437,
0.0048903455,
0.03439364,
-0.006855217,
-0.009283596,
-0.011554114,
-0.16885127,
0.013864936,
-0.0026987586,
0.009834431,
0.019977868,
0.039391465,
-0.005515074,
-0.0008984667,
-0.005185916,
0.017613305,
0.028562842,
0.015571183,
-0.022087166,
-0.011271978,
-0.0021680756,
-0.0066402564,
0.0073892586,
0.021066105,
0.02322914,
-0.0181104,
0.05282648,
-0.004678744,
-0.0008757951,
-0.014267987,
0.00038604677,
0.019373292,
-0.019534511,
0.019427033,
-0.020501833,
-0.01161457,
-0.012756547,
-0.021334805,
0.03724186,
-0.018204445,
0.01075473,
-0.004776148,
0.019238941,
0.014120202,
0.0059550707,
0.009478403,
0.021952815,
0.018123835,
-0.0011873195,
-0.0094918385,
-0.0073623885,
0.027917963,
-0.02215434,
-0.013750738,
0.01759987,
-0.007946812,
0.022476781,
-0.030712444,
0.00862528,
0.0060524745,
0.011574266,
0.009726951,
0.001350219,
0.019534511,
-0.020273438,
0.009888171,
-0.007288496,
-0.010297939,
0.030873666,
0.0032361594,
0.016310109,
-0.039875127,
-0.012326627,
-0.011218238,
-0.013629823,
0.020528704,
-0.0046821027,
-0.031652898,
-0.015329353,
-0.0019480772,
0.030927405,
0.0348773,
0.00007635917,
0.016793769,
-0.0041950834,
0.0258221,
0.0124676945,
0.021522895,
-0.032969527,
-0.02116015,
-0.018983677,
-0.014818822,
-0.014953172,
0.010130001,
0.0033755477,
-0.0015080805,
0.0010319771,
-0.026372936,
0.013549213,
-0.014375467,
0.011151062,
0.028535973,
-0.006972773,
0.0016768578,
-0.010788318,
0.00011136368,
-0.006153237,
-0.0130252475,
-0.011997469,
0.019091157,
0.008215512,
-0.01821788,
-0.030094435,
0.00334196,
0.047183774,
-0.040439397,
0.0012796852,
-0.009370923,
0.025728054,
0.032727696,
-0.010989843,
0.0052362974,
-0.0012922805,
-0.024841344,
-0.020192828,
-0.023887457,
0.06196229,
-0.009135811,
-0.012843874,
0.016538505,
-0.010264352,
-0.030040694,
-0.12456946,
-0.027944831,
-0.0009992293,
0.046108972,
-0.014348596,
0.010291222,
-0.007879636,
0.011399611,
-0.008766348,
0.007449716,
0.00827597,
-0.0063514034,
0.0056662178,
0.0056527825,
0.019010548,
0.009599319,
0.0118160965,
-0.029637644,
-0.018338796,
0.013441733,
0.011083888,
0.012931203,
0.006059192,
-0.01352906,
0.0018405971,
-0.022812657,
-0.0065730815,
0.015221872,
0.026453545,
0.027944831,
0.039149635,
0.004289129,
-0.0012007545,
0.0011083888,
-0.0129513545,
-0.008981308,
-0.0029876116,
-0.007610936,
0.040976796,
-0.027595522,
-0.0028482233,
0.015490573,
0.013139445,
0.0027524987,
0.010150154,
-0.008726043,
0.009142528,
0.02191251,
0.01323349,
-0.013918676,
-0.02713873,
-0.040681228,
-0.019856952,
-0.011218238,
0.016404154,
-0.030685576,
-0.008833523,
0.04428181,
-0.030255655,
-0.016216064,
0.006042398,
0.015356222,
0.00552515,
-0.019816648,
0.014912867,
-0.004705614,
-0.0013267078,
-0.021630375,
0.02220808,
-0.029019633,
0.005988658,
-0.010062827,
-0.024975693,
0.0034494402,
-0.027044686,
-0.017049035,
-0.014711342,
-0.0033520362,
-0.010519617,
-0.009955347,
-0.020622749,
-0.0016432704,
0.007644524,
-0.02261113,
0.038424145,
0.014120202,
0.012736395,
-0.0033520362,
0.005602401,
0.0044805775,
-0.023900893,
-0.0052900375,
0.0045511113,
-0.018674672,
-0.020165958,
0.026990946,
-0.040331915,
-0.032432128,
0.011715333,
0.006193542,
-0.0364895,
-0.0354147,
-0.06432685,
0.014402336,
-0.01328723,
0.0019144897,
-0.001902734,
-0.02242304,
-0.009700081,
-0.011708616,
-0.003805468,
0.03490417,
-0.038612235,
0.013636541,
-0.00218319,
0.005635989,
-0.016753465,
-0.016484763,
0.025217524,
0.005807285,
-0.0030715803,
0.022732046,
-0.029422684,
0.023081357,
-0.007382541,
0.040331915,
-0.019104593,
0.007846049,
0.014106766,
0.011574266,
-0.026023624,
-0.0083767325,
-0.011251826,
-0.03307701,
0.00006245183,
0.0021009005,
-0.015396528,
-0.023363492,
-0.023968067,
0.014657602,
0.009653059,
0.009679928,
-0.020340614,
-0.03498478,
0.008309557,
-0.010694272,
0.00012994179,
-0.007584066,
-0.018688107,
0.008289404,
-0.0054243873,
-0.013696998,
0.024599513,
0.00420516,
-0.014456077,
-0.023605322,
0.009632906,
0.010553204,
0.016592244,
-0.010956255,
0.010499464,
-0.008322992,
0.023618758,
0.0016264765,
0.02150946,
0.027313387,
0.0049508032,
-0.010284504,
-0.0038524906,
0.026265455,
-0.014859127,
-0.028939024,
-0.018365666,
-0.02164381,
0.032136556,
0.0027995214,
0.0039801234,
0.027595522,
0.0126154795,
-0.0053135487,
-0.0107816,
0.005568814,
-0.012890898,
0.0034830277,
-0.0056561413,
0.004571264,
0.05142924,
-0.013408145,
-0.020327179,
0.038451016,
0.0013594556,
-0.0006339648,
-0.012205712,
0.02496226,
0.012346779,
-0.012682655,
0.026211714,
0.027837353,
-0.00075404026,
-0.0023326545,
-0.0060659093,
0.0113324355,
-0.0054512573,
0.017801395,
-0.022664871,
-0.045705922,
0.0004110275,
0.008584975,
-0.017129645,
-0.023175402,
0.005918124,
0.0058845365,
0.007698264,
0.0030010466,
-0.00002191062,
0.0001377089,
-0.0073623885,
-0.00046812632,
-0.0017297582,
-0.021872206,
-0.0050650006,
0.041379847,
0.025392178,
0.032566477,
0.012817005,
0.0074026934,
-0.009646341,
0.033130746,
0.018285057,
-0.03382937,
0.02638637,
-0.009008178,
0.010479312,
0.0089342855,
-0.033560667,
-0.011466785,
-0.009693364,
0.010539769,
0.038585365,
0.021710984,
-0.02282609,
0.090552,
0.011775791,
-0.016726594,
0.014053026,
-0.027447736,
0.008712607,
0.016780334,
0.01711621,
0.014845692,
-0.05193977,
0.028509103,
-0.0006541173,
0.00015586716,
-0.038692843,
-0.02180503,
0.0020689925,
-0.026493851,
-0.0070063607,
-0.0074698688,
0.007093688,
0.010412137,
0.01671316,
-0.0008107192,
0.010875645,
-0.032055948,
0.0060289633,
0.038262922,
-0.0110167125,
-0.009370923,
-0.015289048,
0.0075370437,
-0.001247777,
-0.018177576,
-0.024021808,
-0.009639624,
-0.009169398,
-0.009518708,
-0.019010548,
0.018876197,
0.013623105,
-0.019897258,
0.010035956,
-0.012837158,
-0.048016746,
0.014926302,
0.016027974,
-0.016471328,
-0.0017986126,
-0.014657602
] |
Retinoic acid inducible-gene I (RIG-I) is a cytosolic multidomain protein that detects viral RNA and elicits an antiviral immune response. Two N-terminal caspase activation and recruitment domains (CARDs) transmit the signal, and the regulatory domain prevents signaling in the absence of viral RNA. 5'-triphosphate and double-stranded RNA (dsRNA) are two molecular patterns that enable RIG-I to discriminate pathogenic from self-RNA. However, the function of the DExH box helicase domain that is also required for activity is less clear. Using single-m
|
[
-0.04456032,
0.012899393,
-0.021353498,
-0.0069365297,
-0.0067216516,
0.016156137,
-0.014155086,
0.0060568727,
-0.019728484,
-0.014665421,
0.04018218,
0.007487154,
0.0054525286,
0.00999854,
0.007104403,
0.004035677,
0.01380591,
-0.00055733975,
0.011885438,
0.021756394,
-0.031157305,
0.020587996,
-0.0036663553,
-0.020977462,
0.0029478571,
-0.008319806,
-0.0047340305,
-0.028417611,
-0.0070641134,
-0.01690821,
0.0150414575,
-0.016438164,
0.00008676957,
-0.0016770554,
0.0009988468,
0.01109979,
0.023757445,
-0.01596812,
0.013020262,
0.0063758325,
0.036556114,
0.014947449,
-0.012865818,
-0.0021471009,
-0.0060333707,
0.009985111,
0.008574974,
-0.022535328,
-0.020896882,
0.0036025634,
0.0011658808,
-0.01373876,
-0.029035386,
-0.02229359,
-0.01792888,
-0.0037670794,
0.0047138855,
0.013691756,
0.009286758,
-0.026107673,
-0.013161276,
-0.008366811,
-0.02007766,
0.013926778,
0.02240103,
0.015592082,
0.017351396,
0.013584317,
-0.007218557,
0.005261153,
0.05645919,
0.034407336,
-0.0054458138,
0.011589981,
0.011730994,
-0.014181946,
-0.02542275,
0.0071581225,
0.0046870257,
0.013322434,
0.012335339,
-0.0014638562,
-0.013564172,
0.012402488,
0.010784188,
-0.013188136,
-0.003612636,
0.031882517,
0.016747052,
-0.023569427,
0.01482658,
0.023461988,
0.029223405,
0.03284947,
-0.03881233,
-0.000058336012,
0.017821442,
0.009696368,
-0.015578653,
-0.017217098,
-0.0053450894,
-0.0031929524,
-0.00072017696,
-0.0067585837,
-0.0296263,
0.0028387394,
-0.01376562,
-0.006030013,
0.015498074,
0.0035018395,
-0.027370082,
0.020252248,
0.015014598,
-0.023650007,
0.033306085,
0.0020598068,
0.045876447,
0.017096229,
-0.019795634,
-0.01115351,
-0.0009921319,
0.023273971,
-0.009192748,
-0.02750438,
0.027034335,
0.0061844564,
-0.0145714125,
0.0030704048,
0.0050127003,
-0.011274379,
0.012073456,
-0.0027077983,
0.010965492,
0.0075878785,
-0.0078027565,
0.008695843,
-0.019903071,
-0.014235665,
0.015592082,
-0.017633423,
0.019741913,
0.030512672,
-0.0077691814,
-0.008198937,
0.018560085,
0.0003506456,
0.019929932,
0.0068425206,
-0.019352447,
0.014638562,
-0.0041901204,
-0.020776013,
0.012382343,
-0.0044922926,
0.014934019,
0.027584959,
-0.006154239,
0.016088989,
0.009850812,
-0.012610651,
-0.0071379775,
-0.016814202,
-0.0022679698,
0.020064231,
0.026228542,
0.027141774,
-0.010293998,
0.012100316,
-0.017458836,
-0.0075005842,
0.011187084,
0.016706763,
-0.028390752,
0.017619994,
-0.0036797852,
0.014934019,
0.019527035,
0.015229476,
-0.025919655,
0.006043443,
-0.014329675,
-0.011173654,
0.029921757,
-0.008850287,
-0.009078594,
-0.026940325,
0.015927829,
0.0066276425,
0.00032861222,
-0.030620111,
-0.0016871279,
0.01375219,
0.012899393,
-0.0027766263,
-0.6270139,
-0.02649714,
0.026255403,
-0.019339018,
0.02219958,
0.024146913,
0.02010452,
-0.0011700777,
0.00953521,
0.027155204,
-0.031211026,
0.006805588,
0.025489898,
-0.02219958,
-0.037791662,
-0.035213128,
-0.012402488,
-0.014329675,
0.026000235,
0.011737709,
-0.017042508,
-0.010273853,
-0.013584317,
0.007628168,
-0.006889525,
-0.0023334404,
0.0145714125,
-0.020265678,
-0.010992351,
0.03618008,
-0.017055938,
0.025113862,
0.008057924,
-0.008648838,
0.054605864,
-0.010408152,
0.011281094,
0.030297793,
0.0159144,
0.014437114,
-0.030244075,
0.016250147,
0.025624199,
-0.0014235666,
-0.01482658,
0.012724805,
0.0008981228,
0.030029196,
0.011690704,
-0.014907159,
-0.010152984,
0.0010811047,
-0.025812216,
-0.0026926897,
0.021783255,
0.0027077983,
0.02228016,
-0.014665421,
0.02946514,
-0.008084783,
-0.0020547705,
0.012308478,
-0.009253182,
-0.037845384,
-0.0044687903,
-0.0012128854,
-0.01481315,
0.016733622,
0.0049724104,
0.025261592,
0.023784306,
0.014678852,
0.01112665,
0.011583266,
0.009300187,
0.044345442,
0.01114008,
0.035535444,
0.008930866,
0.025798786,
0.008017634,
-0.013993928,
-0.03271517,
0.008225798,
0.0108916275,
-0.012845674,
-0.011751139,
0.022723345,
-0.00502613,
-0.007366285,
0.0068593076,
0.010576025,
-0.00999854,
-0.037872244,
-0.020977462,
0.01903013,
-0.01698879,
0.021716105,
-0.008400385,
0.0014798042,
-0.016545603,
-0.0035018395,
-0.013268715,
-0.0015477929,
0.02968002,
-0.016491884,
-0.029115966,
-0.0017207025,
0.043002453,
-0.025731636,
-0.01114008,
-0.017821442,
-0.004102826,
-0.005163786,
-0.015484644,
-0.023918604,
0.031345323,
0.011274379,
-0.005348447,
-0.038516875,
0.006164312,
-0.028390752,
0.0024543093,
-0.0057882755,
0.021366928,
0.007191697,
-0.0041162563,
-0.016290436,
0.0042203376,
0.0015033064,
0.01327543,
-0.006117307,
-0.001781137,
-0.016048698,
0.017029079,
0.01590097,
0.01156312,
0.017418545,
-0.013604461,
-0.031264745,
-0.021635525,
-0.019365877,
0.009656079,
-0.008816712,
-0.0044922926,
-0.00343469,
-0.01584725,
0.005929289,
0.019701624,
0.008131788,
0.029223405,
0.017714003,
-0.00094176986,
0.009649364,
0.01270466,
-0.025718207,
-0.017243957,
-0.0046635233,
0.010824477,
-0.007191697,
-0.0057043387,
0.0041901204,
0.0017165056,
0.0072789914,
-0.03078127,
-0.022548757,
0.01596812,
0.009159174,
0.00004760785,
-0.03190938,
0.017485695,
0.000019554629,
-0.018116899,
0.008998015,
0.014329675,
0.030378373,
-0.0045930166,
0.023717156,
-0.013638036,
-0.0038745184,
-0.005687551,
-0.005966221,
-0.015618943,
-0.0100321155,
0.0076953173,
0.019513605,
0.009595645,
0.011744424,
0.03284947,
0.021031182,
-0.02442894,
-0.0039483826,
-0.020507416,
0.042760715,
-0.009810522,
-0.022092141,
0.02954572,
0.011919012,
-0.015686091,
0.030270934,
0.015524933,
-0.028820507,
0.019486746,
-0.0105424505,
0.0015469535,
-0.030082915,
0.0059326463,
-0.026524,
0.0042975596,
0.0020581281,
-0.0038040115,
-0.0017660283,
0.0057412707,
-0.00025642663,
-0.0033138213,
0.030620111,
-0.009528495,
-0.0035757038,
-0.023690296,
-0.016277006,
-0.009501635,
-0.0031224454,
0.020708865,
-0.014289385,
-0.018304918,
-0.005539823,
-0.02013138,
0.011992876,
0.009964966,
-0.02973374,
-0.013926778,
-0.005241008,
0.009716514,
0.025288451,
0.0005489461,
0.008259372,
-0.011260949,
-0.0017240599,
0.015551793,
-0.0136716105,
-0.008715987,
-0.0076818876,
0.006567208,
-0.0008586725,
-0.0013664896,
0.013100841,
0.036744133,
-0.0012674442,
-0.011375102,
0.04343221,
0.0065336335,
0.030136636,
-0.024496088,
0.0043579936,
-0.0036059208,
-0.01579353,
0.020050801,
0.028175874,
0.029411422,
0.024200631,
0.019862782,
0.00738643,
-0.0047642477,
-0.018640663,
0.03298377,
0.0049186912,
-0.0056304745,
0.0026171466,
-0.03271517,
0.000047057016,
-0.021434078,
0.015229476,
0.020870022,
-0.013873059,
0.0098373825,
0.012644226,
0.008440675,
0.006369117,
-0.0034716222,
0.0010139555,
0.0026859746,
-0.040128462,
0.036287516,
0.013940209,
-0.01912414,
-0.018842112,
-0.023448559,
-0.0076617426,
0.020601425,
0.017284246,
-0.0026288978,
0.006432909,
0.0046702386,
0.03158706,
-0.00896444,
-0.009427771,
0.04020904,
-0.035078827,
0.019862782,
-0.010676749,
0.016115848,
-0.02440208,
0.00008010709,
0.0015200938,
0.04356651,
-0.0052712252,
0.008219082,
0.011495971,
-0.006862665,
-0.0072789914,
-0.009293472,
0.0061307373,
0.005979651,
-0.039725564,
0.011066215,
0.014235665,
-0.020695435,
-0.024522949,
0.01010598,
-0.0075878785,
-0.018680954,
-0.033682123,
0.02334112,
-0.0098776715,
0.0062784655,
0.0063254703,
-0.0077557517,
0.02129978,
-0.002405626,
-0.0075475886,
-0.016062127,
-0.030109776,
0.014316245,
-0.023153102,
-0.013134416,
-0.00474746,
-0.007077543,
0.023744015,
0.0058621396,
0.030082915,
0.0055599674,
-0.027396942,
-0.006526918,
0.005110067,
0.008360096,
0.013967068,
-0.0050932793,
0.02424092,
0.005089922,
-0.025087003,
0.009441201,
0.02312624,
-0.0000637919,
-0.022803925,
0.012778524,
0.0011297881,
-0.0080377795,
-0.0070573986,
0.00037456755,
-0.03703959,
0.013873059,
0.007084258,
-0.006426194,
0.0116437,
0.0053115147,
-0.007225272,
0.0018734674,
-0.000062742685,
0.0065403483,
-0.000025233472,
-0.016048698,
0.009380766,
-0.01700222,
-0.012912823,
0.033118065,
-0.005442456,
-0.015659232,
-0.02444237,
-0.013832769,
0.0032298844,
-0.008588403,
-0.003720075,
0.00067443145,
-0.03615322,
0.007097688,
-0.016532173,
0.002083309,
-0.0049287635,
-0.0040323194,
-0.0170828,
0.008930866,
-0.024455799,
-0.035428006,
-0.0036059208,
0.00399203,
-0.02523473,
-0.023824595,
0.015551793,
0.015444354,
0.0127315195,
0.017123088,
-0.009058449,
0.023609716,
0.005261153,
-0.019621044,
-0.0148803,
0.010790903,
-0.03282261,
0.017149948,
-0.0047441027,
0.010898342,
-0.018828683,
-0.008286232,
-0.009595645,
0.0077356067,
0.012684515,
0.034380477,
-0.00738643,
0.010246993,
0.038731754,
0.022938224,
0.013570887,
-0.016129278,
-0.012671085,
-0.025019854,
-0.034622215,
-0.02641656,
-0.019540465,
-0.0070573986,
-0.02332769,
0.01478629,
0.013483592,
-0.0090920245,
-0.014262525,
0.011932442,
0.013403013,
0.01109979,
-0.0026759023,
0.014047647,
0.012268189,
0.0008796567,
0.028927946,
-0.0068962397,
-0.013658181,
-0.03083499,
-0.010858052,
0.008172078,
0.010837908,
-0.027799837,
0.0060938047,
-0.010300713,
-0.019459886,
-0.017861731,
-0.002462703,
-0.006731724,
0.030620111,
0.011240804,
-0.021971272,
0.002279721,
0.0034951244,
-0.0029864681,
-0.0070305387,
0.002083309,
-0.023676867,
0.010670034,
-0.013154561,
0.010690179,
-0.006244891,
0.0006425355,
-0.024939274,
-0.0049186912,
0.020359688,
-0.011771284,
0.01698879,
0.008850287,
-0.029921757,
-0.018922692,
-0.018868972,
-0.019835923,
-0.051302116,
-0.0052242205,
-0.0053853793,
0.024603527,
0.013214995,
0.04002102,
-0.006782086,
0.0057211258,
0.03736191,
0.016532173,
-0.008064639,
0.00009264514,
-0.0023284042,
-0.026725447,
0.010999066,
0.022830784,
-0.011764569,
-0.0013950281,
-0.016277006,
-0.00305026,
0.0027346578,
-0.01579353,
-0.0341656,
0.00289078,
-0.028095294,
-0.029492002,
0.008514539,
-0.0061105923,
-0.0064933435,
-0.02954572,
0.00022893737,
0.011375102,
-0.020816304,
0.027987856,
-0.000978702,
0.02111176,
-0.016518744,
0.036636695,
0.009897817,
0.028793648,
-0.0020262322,
0.004166618,
0.0150011685,
0.0049388357,
0.025489898,
0.024146913,
0.020614855,
0.011019211,
-0.003871161,
0.015162326,
0.01588754,
-0.005177216,
-0.013100841,
-0.0024039473,
-0.018734673,
-0.02109833,
-0.027987856,
-0.019473316,
-0.040826816,
-0.0021991418,
0.018815253,
-0.004781035,
0.02223987,
-0.007507299,
-0.028417611,
0.00555661,
0.00016514547,
0.019137569,
-0.025919655,
0.011361673,
0.032419715,
0.010790903,
-0.025154153,
-0.018707814,
0.0075408737,
-0.01372533,
0.03161392,
0.034085017,
-0.028713068,
-0.01807661,
0.0074938694,
0.0031644139,
-0.014195376,
-0.03271517,
0.020399977,
-0.012610651,
0.0066209272,
-0.0031493052,
-0.01587411,
-0.0057379133,
0.024845265,
-0.001648517,
0.01586068,
-0.015323485,
-0.0020816303,
-0.012362198,
0.01376562,
-0.008574974,
0.015081747,
-0.005408881,
0.00028601434,
-0.0019339017,
-0.020561136,
0.015605513,
-0.001600673,
0.0027296217,
0.034058157,
-0.0037536495,
0.011623555,
0.016585894,
0.0031979885,
0.028122155,
-0.0077893264,
-0.009615789,
0.035642885,
0.005828565,
-0.017727433,
0.017875161,
0.015148897,
-0.0029730382,
-0.005405524,
-0.0059695784,
0.0038443012,
-0.035642885,
-0.005744628,
0.019594185,
-0.01795574,
0.0037536495,
0.011180369,
-0.02219958,
0.00330207,
-0.029277124,
-0.013658181,
0.025704777,
-0.02954572,
0.002998219,
0.008151933,
-0.0019876212,
0.011354958,
0.031237885,
0.012187609,
0.020225389,
0.022911364,
-0.04160575,
0.010945346,
-0.004989198,
-0.002330083,
-0.024214061,
0.017848302,
0.0029209973,
-0.054552145,
0.044936355,
-0.018801823,
-0.02029254,
-0.023381408,
-0.005492818,
0.0027195492,
0.007614738,
-0.02422749,
0.010435011,
-0.0014546232,
-0.003295355,
0.0047776774,
-0.01059617,
0.00529137,
-0.011952587,
0.018372066,
0.010341003,
-0.002323368,
0.007097688,
0.012644226,
-0.003263459,
0.00033637637,
0.0018046392,
-0.046145044,
-0.0075475886,
-0.012503212,
-0.014369965,
0.002323368,
0.017270816,
0.0007621453,
-0.017297676,
0.014705711,
-0.0013077339,
-0.013953638,
-0.008245942,
0.0019271869,
-0.010287283,
-0.007292421,
-0.02324711,
0.0039685275,
-0.010945346,
-0.002197463,
-0.032688312,
0.0047441027,
-0.03808712,
0.029438281,
0.010844623,
-0.025140723,
0.0011927406,
0.0000856679,
-0.03612636,
-0.018842112,
-0.006725009,
0.013557457,
0.00789005,
0.015645802,
0.003814084,
0.0029142825,
-0.023032233,
-0.012946398,
0.0026037167,
-0.01697536,
-0.00046039282,
-0.014665421,
-0.00018675918,
-0.00790348,
-0.03413874,
-0.024160342,
0.031103587,
-0.010354432,
-0.023770876,
0.030002337,
-0.009924676,
0.018667523,
-0.030190354,
0.0051604286,
-0.0018650737,
0.017566275,
0.024872124,
-0.023918604,
-0.005707696,
0.011959302,
0.012395773,
-0.029921757,
0.005146999,
0.0014546232,
0.016841061,
0.0012363876,
-0.019365877,
-0.024737826,
-0.0037737943,
-0.023515709,
0.0060938047,
0.028363893,
0.0190167,
-0.012321909,
0.014907159,
-0.022924794,
-0.020923743,
-0.00013482333,
-0.02131321,
-0.0050496324,
0.011314668,
-0.00952178,
-0.011945873,
-0.009118884,
-0.008339951,
-0.0069365297,
-0.0016308902,
-0.000012577391,
0.0072857062,
-0.02323368,
-0.005939361,
-0.0026540786,
-0.013967068,
-0.00032966142,
0.007487154,
-0.010636459,
-0.014638562,
0.01380591,
0.014987739,
-0.012959828,
-0.010079119,
-0.0087025575,
0.0056103296,
-0.0061307373,
0.0019372592,
-0.004717243,
-0.021071471,
0.009555355,
0.19661334,
0.008373526,
0.019218149,
-0.0030401875,
-0.014463973,
-0.017848302,
0.029492002,
-0.026027095,
-0.008212367,
-0.004112899,
0.03360154,
0.007272276,
0.0041162563,
0.00090064085,
-0.000108488195,
-0.01477286,
-0.01809004,
0.005157071,
-0.026215112,
-0.01109979,
0.03497139,
0.0033356447,
-0.018734673,
-0.011777999,
0.045903306,
0.0078027565,
-0.03481023,
0.0055801123,
0.0077087474,
-0.013443303,
-0.027772978,
-0.008796567,
0.008057924,
0.0006907991,
0.011435537,
0.0050395597,
-0.0096023595,
-0.0096023595,
0.015283195,
0.0038745184,
0.008366811,
0.027020905,
-0.0053182296,
-0.024616957,
0.014611702,
0.020628285,
0.000580842,
-0.027853556,
-0.00900473,
0.023596287,
-0.030109776,
-0.009125599,
0.004932121,
0.006023298,
-0.0073461407,
-0.012335339,
0.015296626,
0.018479506,
-0.0001230722,
-0.0045493697,
-0.016572464,
0.0037670794,
-0.026806027,
0.02957258,
-0.013134416,
0.04550041,
-0.00895101,
0.00999854,
0.023864884,
-0.032419715,
0.008796567,
0.0037368622,
-0.028202733,
0.013349294,
-0.020238819,
-0.01107293,
0.005341732,
-0.0029478571,
0.029894898,
0.009575499,
0.021729534,
0.0004742424,
-0.047998365,
0.023623146,
-0.010367862,
-0.026403131,
0.031291604,
0.00027573208,
-0.047756627,
0.009985111,
0.01375219,
-0.005382022,
-0.020749154,
0.0074267196,
0.0076617426,
-0.0080377795,
-0.023059092,
0.006442982,
0.019218149,
-0.025946515,
-0.040638797,
0.08809997,
0.00399203,
0.016411304,
-0.020493986,
0.012885964,
-0.00049270847,
-0.001442872,
0.0016048698,
-0.014638562,
0.02320682,
-0.013664896,
0.006547063,
0.0051302114,
-0.016156137,
0.016841061,
0.010152984,
-0.021971272,
0.030082915,
-0.009884386,
-0.013288859,
-0.003934953,
-0.008554829,
0.034058157,
-0.011234089,
-0.014692281,
-0.020238819,
-0.0066276425,
0.0027245856,
-0.036233798,
-0.00076088624,
0.008319806,
0.031372182,
0.008863716,
0.017217098,
0.00011467853,
0.0234217,
-0.005858782,
-0.017687144,
0.019567326,
-0.021541517,
-0.011307953,
0.035266846,
0.021326639,
0.00612738,
-0.006315398,
0.031640783,
0.0136716105,
-0.013530597,
0.012919538,
-0.014598272,
-0.027276073,
0.014907159,
0.016035268,
0.019218149,
-0.034058157,
-0.012080171,
-0.013859629,
0.01109979,
-0.0018096754,
-0.01580696,
0.0024039473,
0.02221301,
-0.007305851,
-0.015618943,
0.00053299806,
-0.1697536,
0.0064698416,
0.022266729,
-0.027302932,
0.026994046,
0.020050801,
0.0027799837,
-0.0042774146,
-0.005539823,
-0.0013001796,
0.028793648,
0.009924676,
-0.02017167,
-0.03172136,
0.0019792276,
-0.003585776,
-0.017525984,
0.02422749,
0.0145714125,
0.0011910619,
0.03612636,
-0.025906226,
0.0031778438,
-0.022642765,
0.0058755693,
-0.017405115,
0.008843572,
-0.012462922,
-0.018882401,
-0.0030804772,
-0.014343104,
0.026080813,
0.030109776,
0.0030133277,
0.029062245,
-0.009132314,
0.00584871,
0.017633423,
-0.010925202,
0.026926896,
0.03193624,
0.009528495,
-0.0019725126,
-0.0016703404,
-0.0316945,
0.023367979,
-0.01689478,
-0.006795516,
0.021971272,
-0.006889525,
0.004159903,
-0.013604461,
0.0132015655,
-0.0004314347,
0.041901205,
0.024133483,
0.005324945,
0.026174823,
-0.0076818876,
-0.02865935,
-0.006228104,
-0.00848768,
0.04525867,
-0.013000118,
0.015323485,
-0.0034514775,
-0.00024950187,
0.01890926,
-0.019567326,
0.019204719,
-0.0073461407,
-0.016196428,
-0.029035386,
-0.015148897,
0.020722294,
0.025973374,
-0.013940209,
0.021071471,
0.0035790612,
-0.012926253,
-0.008668983,
0.0014554625,
-0.013926778,
-0.032124255,
-0.000022544875,
-0.0053048,
-0.0018197478,
0.013228425,
0.0073259957,
-0.020896882,
0.018922692,
-0.027074624,
0.011952587,
-0.008843572,
0.0179826,
0.015457784,
0.0056304745,
0.00020018905,
-0.012348768,
-0.00026754825,
0.016585894,
-0.008514539,
0.008628693,
0.019513605,
0.0008771386,
-0.005408881,
-0.02214586,
0.00048809196,
0.039886724,
-0.0140610775,
0.00527794,
0.006983534,
0.011287808,
0.025463039,
-0.016142707,
0.030136636,
-0.03591148,
0.0008628694,
-0.014356534,
-0.026228542,
0.05492818,
0.020735724,
-0.002444237,
0.0053215874,
-0.01161684,
-0.024052903,
-0.12903422,
-0.0040625366,
0.025463039,
-0.01225476,
-0.017418545,
0.032231696,
0.002222644,
0.00527794,
-0.027665539,
0.012872533,
-0.018855542,
-0.0050496324,
-0.0118317185,
-0.014208806,
-0.014034217,
-0.012483067,
0.008628693,
-0.021944413,
-0.0023250468,
0.033279225,
-0.00744015,
-0.017512554,
0.004784392,
0.0024660605,
0.010884912,
-0.01473257,
-0.021877263,
0.010844623,
0.013040407,
0.008084783,
-0.022119,
-0.015645802,
0.020708865,
-0.0032181332,
-0.041713186,
-0.01327543,
0.018654093,
-0.030539531,
0.02761182,
-0.006547063,
0.021877263,
0.009776948,
-0.011281094,
0.014141656,
0.01217418,
-0.0011801501,
0.022777066,
0.010233563,
0.003720075,
0.002204178,
-0.02011795,
-0.032876328,
-0.030190354,
-0.025879366,
0.010777473,
-0.008219082,
0.023367979,
0.012812099,
-0.00028328638,
0.0039786,
0.00896444,
0.0057177683,
-0.012603936,
0.008715987,
0.035535444,
-0.024818406,
-0.020964032,
-0.025839075,
0.02429464,
-0.029062245,
0.022857644,
0.0066712894,
-0.005146999,
0.0065504205,
-0.025543619,
0.01107293,
-0.016720193,
-0.018224338,
0.0075408737,
-0.018358637,
-0.017324537,
-0.024670677,
0.011220659,
-0.013577602,
0.028498191,
0.0027917349,
-0.015028028,
-0.02330083,
-0.0049019037,
-0.02313967,
-0.015336915,
0.036072638,
-0.005576755,
-0.012073456,
-0.008225798,
0.0031845586,
-0.0060333707,
-0.0073797153,
-0.010797618,
0.036475535,
-0.025382461,
-0.009783663,
-0.067417964,
0.0034380476,
-0.00690967,
0.0013480235,
0.011522831,
-0.039618127,
0.019352447,
-0.011502686,
-0.0016585893,
0.010085835,
-0.021944413,
0.007084258,
-0.008286232,
0.018546654,
-0.014692281,
-0.042787574,
0.04901904,
0.00040562413,
0.018210908,
0.023703726,
-0.005284655,
0.0068022306,
-0.0044352156,
0.013745476,
-0.0008486001,
0.0051234965,
-0.026309121,
0.009125599,
-0.010341003,
-0.0055465377,
-0.013651466,
-0.046064466,
-0.014007358,
0.011986162,
-0.0087428475,
-0.018519795,
-0.010408152,
0.020386547,
0.026591148,
0.015820391,
-0.017687144,
-0.032876328,
0.011798143,
0.016478455,
0.014759431,
0.0031459478,
-0.048025228,
0.0019792276,
0.015444354,
-0.015028028,
0.03282261,
0.020225389,
-0.020749154,
-0.0042572697,
-0.006244891,
-0.01262408,
0.0061676693,
-0.045983884,
-0.008386956,
-0.015672661,
0.016545603,
-0.005284655,
0.017512554,
-0.005707696,
0.017243957,
-0.011294523,
-0.037899103,
0.0013874738,
-0.008004204,
-0.02218615,
-0.028498191,
0.0011767927,
0.0013975461,
-0.0021319923,
0.029035386,
0.00958893,
-0.0023955535,
-0.0006152561,
-0.015605513,
0.013483592,
0.0118317185,
0.0030049342,
-0.0042471974,
0.0060535152,
-0.00013860049,
0.0036764278,
-0.004086039,
0.0154712135,
0.0034195813,
0.012362198,
0.0024089834,
0.029975478,
0.0062247464,
0.008521254,
0.026000235,
0.0021051327,
-0.018788392,
0.013792479,
0.013100841,
0.029948616,
0.029357703,
0.014799721,
-0.006006511,
-0.027746119,
0.023770876,
0.034380477,
-0.023354549,
-0.03806026,
-0.009629219,
-0.024522949,
0.010112694,
-0.0022813997,
0.0005783239,
0.017660283,
-0.0116772745,
0.0018533225,
0.010790903,
-0.009280043,
-0.016277006,
0.029115966,
0.016008409,
0.028229594,
-0.0065772804,
-0.027799837,
0.018049749,
0.029706879,
0.044828918,
-0.016478455,
0.032285415,
-0.017834872,
0.012973257,
-0.0074535795,
-0.0065974253,
-0.015712952,
-0.008514539,
-0.002778305,
-0.0063926196,
0.018197479,
-0.040692516,
0.09051734,
0.020453697,
-0.010341003,
0.0043344917,
-0.022602476,
0.02218615,
0.0010752293,
0.023582857,
-0.015672661,
-0.023958893,
0.023515709,
-0.018748103,
0.037845384,
-0.018694384,
-0.03806026,
0.012422632,
-0.021756394,
0.030969288,
-0.0013950281,
-0.00958893,
0.00839367,
-0.016411304,
0.007366285,
-0.00448222,
-0.038543735,
0.009461346,
0.019406166,
0.0016569106,
-0.0014798042,
-0.024066333,
0.015659232,
0.0046769534,
-0.01698879,
-0.0044049984,
-0.00085573475,
-0.008044494,
-0.0021957844,
-0.00072479347,
0.0157801,
0.040477637,
0.00637919,
-0.0024778116,
-0.014719141,
-0.040719375,
0.02120577,
0.006409407,
-0.043861967,
-0.0039114505,
-0.018278057
] |
Interleukin-10 (IL-10) suppresses the maturation and cytokine production of dendritic cells (DCs), key regulators of adaptive immunity, and prevents the activation and polarization of naïve T cells towards protective gamma interferon-producing effectors. We hypothesized that human cytomegalovirus (HCMV) utilizes its viral IL-10 homolog (cmvIL-10) to attenuate DC functionality, thereby subverting the efficient induction of antiviral immune responses. RNA and protein analyses demonstrated that the cmvIL-10 gene was expressed with late gene kinetics. Treatment of immature DCs
|
[
-0.03171021,
-0.00656817,
-0.014953207,
-0.033095732,
-0.0070583317,
0.015044704,
-0.0332003,
-0.0047970517,
-0.013188624,
-0.027632063,
0.024821801,
0.0047447677,
0.0071106157,
-0.00862685,
-0.006460334,
-0.0083262175,
0.028442463,
-0.009875129,
-0.017828824,
-0.008149759,
-0.035082523,
0.0098882,
0.013633037,
-0.028703883,
-0.020103175,
0.004757839,
0.016260305,
-0.056728076,
-0.014691787,
0.007718417,
0.0097182775,
-0.0017678507,
0.012325939,
0.0134761855,
-0.00085941725,
-0.024573453,
0.02454731,
-0.009365361,
0.01161357,
-0.0061139534,
0.013116733,
0.017410552,
0.00059963146,
-0.0009697037,
0.0039833826,
0.022756586,
0.013829102,
-0.022194533,
-0.014966278,
0.0040520052,
0.018586941,
0.010313007,
0.0019720849,
0.015946602,
-0.027422927,
-0.0038199953,
0.012430507,
-0.01141097,
0.016848499,
-0.035239376,
-0.017567404,
-0.0024279354,
-0.016168809,
0.0098882,
0.019750258,
0.026063545,
-0.013763747,
0.023815334,
0.006120489,
0.008195507,
0.031135086,
0.05149968,
-0.011169157,
0.0060812756,
-0.0005395866,
-0.010855453,
-0.007097545,
0.0033723142,
-0.0029164637,
-0.0025668147,
0.020312311,
-0.03811499,
-0.004705555,
0.017136062,
0.019684903,
0.0014018632,
0.005447333,
0.006555099,
0.0007867099,
-0.01776347,
0.018521586,
0.0013307896,
0.03223305,
0.036311198,
-0.01738441,
0.0072347904,
0.00190673,
0.02998484,
0.010737814,
0.008920947,
-0.0073655,
-0.007940623,
-0.019606477,
-0.014744071,
-0.0341937,
-0.020508375,
-0.007953694,
0.019253561,
0.027945766,
-0.010424111,
-0.0240114,
0.016953068,
-0.013253978,
-0.05055857,
0.014142806,
0.006038795,
0.007483139,
0.0024883887,
-0.008188972,
0.004009525,
0.025318498,
0.033383295,
0.012691926,
-0.024991723,
0.008456928,
0.0042219283,
-0.018809147,
-0.014234303,
-0.04457206,
0.0009950288,
0.015985815,
-0.009228116,
0.0012809566,
-0.0013454945,
-0.01326705,
0.022207603,
-0.00008317435,
0.0048591387,
0.0059276917,
-0.007751094,
0.010705137,
0.033252586,
0.009136618,
-0.009051657,
0.008731418,
0.009829381,
0.018691508,
0.01141097,
0.00014939728,
-0.0050519356,
-0.028102618,
-0.028547032,
0.003888618,
-0.0014394423,
0.00018830388,
0.026076615,
-0.0084307855,
0.03529166,
-0.0036337338,
-0.011901132,
-0.0019165332,
-0.03382771,
0.021723976,
0.0009991134,
-0.0036631436,
0.015632898,
-0.0036271983,
0.0075681005,
0.0042317314,
-0.004006257,
0.0014296389,
0.023174856,
-0.031135086,
0.021527912,
-0.027318358,
0.033148017,
-0.009620245,
0.012397829,
-0.012195229,
-0.031213513,
-0.0034442046,
0.018064102,
0.02121421,
0.0034409368,
-0.014940136,
-0.0076726684,
0.041356597,
-0.011959951,
-0.001931238,
-0.010724743,
0.0056662722,
0.021475628,
-0.017449765,
-0.029697279,
-0.62657076,
-0.025553776,
0.030769099,
-0.0019606478,
-0.0020145655,
0.02507015,
0.015842034,
-0.01354154,
-0.014574149,
0.011371757,
0.00057675724,
0.0075419582,
0.013567682,
-0.021057356,
-0.027919624,
-0.033461723,
-0.0013863414,
-0.00801905,
0.0036500725,
-0.0061498983,
-0.010319543,
-0.0007985555,
-0.0070583317,
0.0055192234,
-0.0068099834,
0.0016542965,
0.053695608,
0.0044735447,
0.0044833478,
0.030376969,
-0.0018135991,
0.028154902,
-0.01167239,
0.0026419729,
0.060021963,
0.023658482,
-0.024246678,
0.012744211,
-0.011659319,
0.026507957,
-0.021972327,
-0.008195507,
-0.0020652157,
0.013129804,
-0.028050333,
0.011907667,
0.00540812,
0.011188763,
0.020756723,
-0.024821801,
0.0160381,
-0.005293749,
-0.0051434324,
0.0029426054,
0.0071302224,
-0.0026811857,
0.01486171,
-0.01950191,
0.020795938,
0.0042055896,
-0.003463811,
0.009659458,
0.012129874,
-0.012999095,
-0.008679134,
-0.007561565,
0.0031141622,
-0.00022302369,
0.011084195,
-0.009790168,
0.012051448,
0.028886877,
0.0042709443,
-0.003179517,
0.013946741,
0.011476325,
-0.0049767774,
-0.011639712,
-0.00076056796,
0.012358616,
0.001609365,
-0.016391015,
-0.02666481,
-0.012391293,
0.007123687,
-0.016665505,
-0.0133716175,
0.0071106157,
-0.0014770213,
0.021540983,
0.021593267,
0.021174995,
-0.011633176,
-0.03395842,
-0.02003782,
0.015384549,
-0.0039310986,
-0.00021342468,
-0.009012444,
0.005600917,
0.0046173255,
0.011456719,
-0.0021485433,
-0.0013226203,
0.011783493,
0.016116524,
-0.047944374,
0.0073589645,
0.04977431,
-0.016665505,
0.0031615444,
-0.006460334,
-0.007241326,
0.005123826,
0.032808173,
-0.01592046,
0.0160381,
-0.0033527077,
-0.006751164,
-0.015240769,
0.015162342,
-0.0058525335,
0.00782952,
0.012678855,
0.0030618783,
0.01028033,
-0.0026550437,
-0.0015677012,
-0.010103871,
-0.01565904,
0.020312311,
0.011018841,
0.017005352,
-0.02640339,
0.04433678,
0.027841197,
0.045748446,
-0.013776818,
-0.021580197,
-0.010777027,
-0.049748167,
-0.030167833,
-0.009698671,
-0.017854966,
0.0017417087,
0.00520552,
-0.0036435372,
0.0012270387,
0.015985815,
-0.0043330314,
0.009273864,
-0.00762692,
0.011116873,
0.017018422,
0.0027400053,
-0.02602433,
0.01751512,
-0.019632619,
0.0018952928,
-0.020194672,
-0.0070648673,
0.031135086,
-0.003980115,
0.0065877764,
-0.010705137,
0.0016044634,
0.019410413,
0.00875756,
0.0007646526,
-0.030220117,
-0.015606756,
-0.0037186951,
-0.015855106,
0.010116942,
0.009809774,
0.0087510245,
0.003489953,
-0.011234512,
-0.020495305,
0.0035455048,
0.008613779,
-0.0073197517,
0.0060943468,
-0.016234163,
0.04033706,
0.009626781,
0.029409716,
0.019292774,
0.013789889,
0.044964187,
-0.025488421,
0.0072543966,
-0.0098882,
0.018573869,
0.0145480065,
-0.020469163,
0.011554751,
-0.00053917815,
-0.0052872133,
0.025122434,
-0.009835917,
-0.023723837,
-0.0009884932,
-0.0063100182,
-0.0042807474,
-0.022586662,
-0.0122083,
-0.035343945,
0.009313077,
-0.0034866852,
0.003568379,
0.0027089617,
-0.0099339485,
0.01816867,
0.0038363342,
0.008790238,
-0.030847525,
0.007378571,
-0.0035389692,
-0.019606477,
-0.0050650067,
-0.020456092,
0.025488421,
-0.029226722,
0.0026305357,
0.00888827,
-0.00021873477,
0.010639782,
-0.0024769516,
-0.019671833,
-0.01146979,
-0.003967044,
0.0028364037,
0.015319195,
-0.0046271286,
0.013169018,
0.0056139883,
-0.011888061,
0.046401996,
0.0032367026,
-0.002060314,
-0.0062381276,
0.0009451956,
0.008241256,
-0.007378571,
-0.025828267,
0.027396785,
0.0021665157,
-0.015227698,
0.02054759,
-0.02057373,
-0.0029556765,
0.0034801497,
-0.014417296,
-0.0031092605,
-0.0043493705,
0.006091079,
-0.0018871234,
0.046532705,
0.024795659,
0.021005074,
-0.021828545,
0.004431064,
-0.015162342,
0.00024385557,
0.0049931165,
-0.0026419729,
-0.000088637615,
-0.021331847,
-0.009182367,
-0.019593406,
0.0003420922,
0.021920042,
-0.03343558,
0.002769415,
0.012685391,
-0.01174428,
0.015541401,
0.008894805,
0.022011539,
-0.018600011,
-0.03343558,
0.020246956,
0.00007102242,
-0.008816379,
-0.01061364,
-0.029305149,
-0.0030242992,
-0.000059891663,
0.008339289,
-0.014940136,
0.024390457,
0.019619549,
-0.0072217193,
0.0021322044,
0.009378431,
0.032311477,
-0.014090522,
0.0073197517,
0.019724116,
0.00026897638,
-0.00553883,
-0.011750815,
-0.017162204,
0.019972466,
0.005254536,
0.0071302224,
-0.021671694,
-0.009875129,
-0.0006490561,
-0.0112279765,
0.006326357,
0.0027596117,
0.0023707498,
0.018351663,
0.0025978582,
0.0022841545,
-0.0032955222,
0.016939996,
0.0046401997,
-0.020887434,
-0.038716257,
0.0061760405,
-0.01419509,
0.0135807535,
0.018011818,
-0.010339149,
0.0155152595,
-0.0041140923,
0.029749561,
-0.02839018,
-0.018586941,
0.02256052,
-0.023109501,
-0.014561078,
-0.008136688,
-0.009058192,
-0.006731557,
0.00862685,
0.015855106,
0.018756863,
-0.012881456,
-0.0064211213,
0.013724534,
-0.0040225955,
0.012685391,
0.0051565035,
0.037226167,
0.022181462,
-0.0046826806,
0.0077445586,
0.0273445,
-0.016417157,
-0.014887852,
-0.0022612803,
0.02906987,
0.0060616694,
0.022978792,
-0.0039637764,
-0.033723142,
0.014247374,
0.02056066,
0.0016248869,
0.007071403,
0.032729745,
0.04190558,
0.005682611,
0.0012695194,
0.0023985258,
-0.0010489465,
-0.016783144,
0.020900505,
-0.003308593,
-0.047160115,
0.033592433,
-0.029435858,
0.0011437112,
-0.008783702,
0.0025521098,
-0.006045331,
-0.0052512684,
0.015972743,
-0.010273795,
-0.0014557809,
-0.029148297,
-0.027527494,
0.02389376,
-0.012240978,
-0.03398456,
-0.020063963,
-0.009469928,
-0.0063917115,
-0.01055482,
-0.023815334,
0.0064832084,
-0.012914133,
-0.0145480065,
0.007868733,
0.006091079,
0.008973232,
0.022076894,
-0.031893205,
0.023828406,
0.0197764,
-0.013012165,
-0.020586802,
0.016822359,
-0.0341937,
0.022782726,
0.00941111,
-0.0025537438,
0.005368907,
-0.02628575,
-0.02083515,
-0.015606756,
0.0009909441,
0.015672112,
-0.007836056,
-0.015214627,
0.017881108,
0.0118619185,
0.04010178,
-0.0022449417,
-0.02096586,
-0.019580336,
-0.025802124,
-0.018508514,
-0.015881246,
-0.014966278,
-0.016861571,
0.0017433426,
0.01113648,
-0.0040879506,
-0.024115967,
0.007071403,
-0.015293052,
-0.009384967,
-0.013247443,
0.019684903,
0.0164433,
0.010594034,
0.0078099137,
0.0022678159,
-0.032128483,
-0.031945486,
-0.028468605,
0.017828824,
-0.0011526975,
-0.020756723,
-0.0057381624,
0.0064472635,
-0.012025306,
-0.017724255,
-0.010796634,
-0.012240978,
0.019841755,
0.0052349297,
-0.022377526,
-0.043160394,
-0.009345754,
0.010927344,
0.01816867,
0.0034964886,
-0.022403669,
0.00055061525,
0.014495722,
-0.012502397,
-0.010783562,
0.029566567,
-0.030272402,
0.0045029544,
0.019593406,
0.021384131,
0.012057983,
-0.0041925185,
-0.014404225,
-0.024625735,
-0.0019296042,
-0.024534239,
-0.021658622,
0.015240769,
-0.0106789945,
0.04600987,
0.010927344,
0.045408603,
-0.02054759,
0.009489535,
0.00530682,
0.023135643,
0.0013610163,
0.0041304315,
0.028468605,
-0.009953555,
0.0029197312,
0.0029654796,
-0.009267328,
0.016234163,
-0.022312172,
0.020482233,
0.0008765729,
-0.010999233,
-0.035866782,
0.0004000947,
-0.009561426,
-0.013606896,
0.014665646,
-0.013829102,
-0.0028870539,
-0.035370085,
-0.011090731,
0.022207603,
0.020469163,
0.0153061235,
0.003976847,
0.018613083,
-0.01697921,
0.016678577,
-0.024259748,
0.006064937,
0.012221371,
0.012450113,
0.0051303618,
0.011763887,
0.03649419,
0.007685739,
0.0063524987,
0.026494887,
-0.02402447,
0.013240908,
0.010234581,
-0.027239934,
-0.024233606,
-0.018613083,
-0.01990711,
-0.016129596,
-0.025174716,
-0.0060191886,
-0.029017586,
0.0139075285,
0.002307029,
-0.019606477,
0.011031912,
-0.009927413,
-0.016508654,
0.049617458,
0.009313077,
0.026717093,
-0.03607592,
0.017227558,
0.0041140923,
-0.0121886935,
-0.012685391,
-0.009927413,
0.007600778,
0.0039605084,
0.034376692,
0.03129194,
0.010966556,
-0.010123478,
0.015763609,
-0.003463811,
0.0150839165,
-0.023697697,
0.024573453,
0.01300563,
0.011633176,
-0.0115482155,
-0.030481538,
-0.02666481,
0.013999025,
-0.0012074322,
0.019593406,
-0.006718486,
-0.016404087,
-0.005473475,
0.0055943816,
-0.0036075918,
0.015201556,
-0.0021027948,
-0.019018283,
-0.005924424,
-0.037200022,
0.007738023,
0.0071302224,
-0.0053035524,
0.022482093,
0.0153061235,
0.0018364734,
0.012665785,
-0.016822359,
0.013332405,
0.018011818,
-0.024168251,
0.042637553,
0.005100952,
0.0008798407,
0.0017629492,
-0.012057983,
0.01776347,
-0.011064589,
0.0070387255,
0.0013822566,
-0.030821383,
-0.0075158165,
0.026507957,
0.008345824,
-0.016181879,
0.042689838,
-0.024991723,
0.0004791333,
-0.034062985,
-0.024037542,
0.019135922,
-0.036128204,
0.004133699,
-0.009809774,
0.012979488,
0.015214627,
0.010071194,
0.010195368,
-0.0029475072,
0.016560938,
-0.023436276,
0.012495861,
0.007594242,
-0.0020031284,
-0.01526691,
-0.0072543966,
-0.014103593,
-0.033696998,
0.016913855,
-0.0141166635,
-0.04321268,
-0.040546197,
-0.008522282,
0.0002806177,
-0.0024671485,
-0.019959394,
0.0038396018,
0.008999373,
0.00941111,
0.0038036567,
-0.018756863,
0.018273236,
-0.028364038,
-0.011391363,
0.017606616,
-0.006908016,
-0.00049669744,
0.0048493356,
-0.00030410464,
0.012606965,
-0.03275589,
-0.0106789945,
-0.011783493,
0.016626293,
0.008202043,
-0.006244663,
-0.0051074876,
0.001339776,
-0.024468884,
0.001275238,
-0.008319682,
-0.0012425606,
-0.0032742817,
0.0036141274,
-0.0043461025,
0.027266074,
-0.018913716,
-0.002960578,
0.006460334,
-0.034690395,
-0.015698252,
-0.008620314,
-0.010097336,
0.029409716,
-0.009404574,
0.0077576297,
-0.024102896,
-0.008208578,
-0.046114434,
-0.03144879,
0.022312172,
0.013463114,
0.0044114576,
0.018077172,
-0.021789333,
-0.01352847,
-0.013816032,
0.012763817,
-0.011809635,
-0.018965999,
0.008156295,
0.010130013,
0.034167554,
0.0026452406,
0.005257804,
0.000033851808,
0.03265132,
0.016417157,
-0.003918028,
0.033383295,
-0.0075288876,
0.00038477711,
-0.022730444,
0.018364733,
-0.018652296,
-0.004558506,
0.002550476,
-0.021671694,
-0.00942418,
0.0072674677,
-0.014273516,
-0.0043755122,
-0.009345754,
-0.035056382,
-0.009358825,
0.0036892856,
-0.0016265207,
-0.043735515,
0.0035389692,
-0.021318777,
0.01254161,
0.025671415,
0.013116733,
-0.00703219,
0.0050650067,
-0.004558506,
-0.0062250565,
0.009339219,
-0.00019739229,
-0.015776679,
0.020456092,
0.009803238,
-0.019305846,
0.0073458934,
0.014155877,
-0.021397203,
-0.01187499,
0.0012057984,
0.021593267,
-0.034690395,
0.0072021126,
0.010143084,
0.012267119,
0.0052381973,
-0.0014271882,
-0.0011306402,
-0.009986233,
0.016364872,
0.0014206527,
-0.0022710836,
-0.012084126,
0.024704162,
-0.030690674,
-0.010306472,
-0.015711324,
-0.0061727725,
-0.0036010563,
-0.005757769,
0.19303231,
-0.0069537642,
-0.009750955,
0.009469928,
-0.012757282,
0.010672459,
0.0145480065,
-0.007862197,
0.0019933253,
-0.0052480004,
0.022795798,
-0.014286587,
0.0069864416,
-0.00025406727,
0.004470277,
-0.020482233,
-0.01287492,
-0.008875199,
-0.024246678,
-0.027919624,
0.012025306,
0.009358825,
0.017175274,
-0.0013724534,
0.039709654,
-0.005381978,
-0.032285333,
0.03050768,
0.0056107203,
0.014966278,
-0.03356629,
-0.0074373903,
-0.002099527,
0.0097117415,
0.019697975,
0.011659319,
-0.02535771,
-0.01658708,
-0.00034842343,
0.0012597162,
-0.0039637764,
-0.014378084,
-0.03461197,
0.012397829,
-0.011920738,
0.041382737,
0.0115416795,
-0.018286308,
-0.00082347204,
0.0074504614,
-0.025396924,
-0.00043542718,
0.02295265,
0.028207187,
0.0014631334,
0.0012262218,
0.012195229,
0.018691508,
-0.01670472,
0.015057775,
-0.02016853,
0.013868315,
-0.009659458,
0.029279007,
-0.010430646,
0.032180764,
-0.01055482,
-0.0025945904,
0.00507481,
-0.026351105,
0.02718765,
-0.0065093506,
-0.024181323,
-0.0110057695,
-0.022416739,
-0.02005089,
0.013972883,
0.019318916,
0.013123269,
0.011169157,
0.0127246035,
0.00762692,
-0.029331291,
0.005525759,
0.016103454,
-0.039160673,
0.021331847,
-0.0017106652,
-0.017162204,
-0.012652714,
0.012502397,
-0.013920599,
-0.016913855,
0.008868664,
0.029435858,
-0.0071694353,
-0.0121886935,
-0.012450113,
0.028651599,
-0.008947089,
-0.028050333,
0.07257011,
0.020495305,
-0.0043199607,
0.002408329,
0.016796216,
0.0026158309,
-0.0139075285,
-0.010966556,
-0.021292634,
0.015345337,
-0.03544851,
0.009012444,
-0.0028151635,
0.002808628,
0.018090243,
0.01699228,
-0.022364456,
0.008175901,
-0.0045552384,
0.021331847,
-0.013123269,
-0.0071106157,
0.03453354,
0.00018442344,
0.004767642,
-0.037383016,
0.0074373903,
0.011796564,
-0.035213232,
0.014652574,
-0.0030553427,
0.010031981,
0.018247096,
0.02534464,
-0.0042742123,
0.035892926,
-0.0071106157,
-0.017685043,
0.01605117,
-0.024534239,
-0.007548494,
0.031762492,
-0.008940554,
-0.003924563,
-0.00048893655,
0.029435858,
0.030847525,
-0.011842312,
-0.02891302,
-0.012142945,
-0.037749004,
-0.010103871,
-0.005483278,
0.011358686,
-0.014051309,
-0.015332266,
-0.011698532,
-0.0014565979,
-0.007470068,
-0.01990711,
0.012535075,
0.02070444,
-0.025775982,
-0.018142527,
-0.0043853153,
-0.16208021,
0.0043330314,
0.001082441,
-0.03173635,
0.031213513,
0.014874781,
0.0042317314,
-0.028364038,
-0.01088813,
0.017162204,
0.03811499,
0.01445651,
-0.04258527,
0.0018887573,
0.0008961794,
-0.007646526,
-0.02374998,
0.03463811,
0.016364872,
0.012417436,
0.03900382,
-0.025174716,
-0.008090939,
-0.016743932,
0.0066433284,
0.027161507,
-0.011691996,
0.00027898385,
-0.0052904813,
-0.01803796,
-0.005202252,
-0.0066237217,
0.030899808,
-0.012933739,
0.025919763,
-0.014534935,
0.017881108,
0.009522213,
0.0023707498,
0.0332003,
0.030010981,
0.00640805,
0.002045609,
0.019292774,
-0.0172537,
0.030298544,
-0.0062642694,
-0.0013683687,
0.011580893,
-0.0090777995,
0.03275589,
-0.016822359,
0.027213791,
0.0014165681,
0.015985815,
0.0033886528,
0.017828824,
0.00949607,
-0.00016788047,
0.0057250913,
0.0024132307,
-0.015724394,
0.02679552,
0.0126135005,
0.02110964,
-0.042611413,
0.0054571363,
0.04815351,
-0.008469998,
0.00293607,
-0.029383574,
-0.007280539,
0.021789333,
-0.0049996516,
0.017410552,
0.013789889,
-0.007097545,
0.01697921,
0.007685739,
0.012959882,
-0.017201416,
0.0023413403,
-0.03317416,
-0.005793714,
-0.03343558,
0.0106855305,
0.0011134845,
0.027658204,
0.0053787106,
0.0035291659,
-0.007136758,
-0.025253143,
0.0049669743,
-0.010463323,
0.017292913,
0.04381394,
0.0028037264,
-0.0006004484,
-0.012417436,
0.026847804,
-0.011894597,
-0.015136201,
0.00051426154,
-0.009927413,
0.0074504614,
-0.01419509,
-0.031108944,
0.017593546,
0.026547171,
-0.0057741078,
-0.0034572755,
0.0126135005,
0.007724952,
0.016129596,
0.002524334,
0.006927622,
-0.012855314,
-0.01148286,
-0.0218939,
-0.018796077,
0.07267468,
-0.0037317662,
-0.024625735,
0.0034409368,
-0.034324408,
-0.014874781,
-0.15068232,
-0.026494887,
0.017319055,
-0.014103593,
-0.023057217,
0.019214349,
-0.01539762,
0.01578975,
-0.022050751,
0.0087510245,
-0.033696998,
0.00069071987,
-0.004636932,
-0.008058262,
0.0029556765,
-0.0050846133,
0.0028216988,
-0.016155738,
-0.02920058,
0.035265516,
0.0017678507,
-0.019475767,
-0.005163039,
-0.004636932,
0.012691926,
0.0008075418,
-0.0201816,
0.02825947,
0.033357155,
0.026429532,
0.024586523,
-0.008849056,
0.03063839,
0.0076595973,
-0.02095279,
-0.01022151,
-0.0060485983,
-0.02160634,
0.027553637,
-0.020273099,
-0.0043362994,
0.0038788149,
0.0014133003,
-0.019318916,
0.042088572,
-0.0058558015,
-0.013972883,
-0.005123826,
0.023763051,
-0.014822497,
-0.033357155,
-0.029618852,
-0.04525175,
-0.023540843,
-0.000040208597,
-0.019044425,
0.027370643,
0.020286169,
-0.035108667,
-0.014927065,
0.00013918556,
0.008731418,
-0.013025236,
0.010110407,
0.02599819,
-0.03092595,
-0.010692066,
-0.019972466,
0.028311754,
-0.041618016,
-0.00075566635,
-0.016077312,
-0.005123826,
-0.02601126,
-0.0019900575,
0.02469109,
-0.014731,
-0.011038447,
0.0030144958,
-0.010299936,
-0.03304345,
-0.021750119,
0.029226722,
0.015462975,
0.029488143,
0.0073589645,
0.002383821,
-0.007751094,
0.0010007473,
-0.0017417087,
0.002254745,
0.048179653,
0.0040258635,
-0.008515746,
-0.014273516,
0.028965304,
-0.019998606,
-0.0034703466,
0.03808885,
0.018534657,
-0.013044843,
-0.01128026,
-0.05204866,
0.017136062,
-0.019828685,
0.010031981,
0.0005109938,
-0.017854966,
-0.0010317909,
-0.02227296,
0.014927065,
0.0028658134,
-0.015737467,
0.016521726,
-0.02163248,
0.0366249,
-0.030298544,
-0.012972953,
0.0261289,
-0.009829381,
0.009032051,
0.0043983865,
-0.0026893553,
-0.003797121,
-0.018939856,
0.028703883,
-0.008947089,
-0.004901619,
0.010868524,
0.02257359,
-0.0098882,
0.011894597,
-0.003901689,
-0.02507015,
-0.014626432,
0.0073655,
-0.005391781,
-0.014508793,
-0.020220814,
0.039317522,
0.013959812,
0.030403111,
-0.009267328,
-0.045199465,
0.005940763,
0.004705555,
-0.01248279,
0.0069014803,
-0.042166997,
0.010731279,
-0.00044645584,
-0.020390736,
0.0525715,
-0.0021665157,
-0.0076922746,
-0.037200022,
-0.011842312,
0.015201556,
0.008927483,
-0.025122434,
-0.0025896889,
0.0059276917,
-0.008032121,
0.017750397,
0.0017172006,
0.019462697,
0.0030030587,
-0.017854966,
-0.022704301,
0.011574357,
-0.010979627,
0.011247583,
-0.019933252,
0.0073851068,
0.006107418,
-0.002922999,
0.007260932,
0.000560827,
-0.010058123,
0.008450392,
-0.00801905,
0.009522213,
0.0064341924,
-0.0055715074,
-0.008267398,
0.012378223,
0.022978792,
0.012718068,
-0.0081040105,
0.037200022,
0.0025079953,
0.004382048,
-0.002318466,
0.019985536,
0.016678577,
-0.002473684,
0.016913855,
0.023580058,
0.013227837,
0.024181323,
0.003695821,
0.04099061,
0.01445651,
-0.0007887523,
0.008437321,
-0.0013103662,
0.003385385,
0.018626153,
-0.024325103,
-0.037618294,
-0.0155152595,
0.004904887,
0.011829241,
0.007391642,
0.0052904813,
0.0064864764,
-0.025671415,
0.010169227,
-0.0006278157,
0.0066662026,
-0.021174995,
0.030324684,
0.010927344,
0.015201556,
0.0036141274,
-0.014927065,
0.004251338,
0.015489117,
0.027292216,
-0.016848499,
0.03453354,
0.00822165,
0.018887574,
-0.008097475,
-0.024900226,
-0.017397482,
-0.0047970517,
0.015502188,
-0.004453938,
0.0131559465,
-0.0005783911,
0.06551178,
0.005257804,
-0.029148297,
-0.014704858,
-0.014247374,
0.012495861,
0.005574775,
0.014940136,
-0.0019132654,
-0.027213791,
0.033121876,
-0.011770422,
0.037147738,
-0.03199777,
-0.040938325,
0.019305846,
-0.013999025,
0.015842034,
0.00139206,
-0.008835986,
0.017606616,
-0.004519293,
-0.012587358,
0.0059799757,
-0.04454592,
-0.012881456,
0.013920599,
-0.0023380725,
-0.004931029,
-0.032572895,
0.020011678,
0.0033004237,
-0.034977958,
-0.013312798,
-0.003901689,
-0.02361927,
0.009587567,
-0.016482512,
0.016639365,
0.032206908,
-0.003359243,
0.02440353,
-0.012606965,
-0.02705694,
0.011352151,
-0.019619549,
-0.013175553,
-0.023200998,
-0.01214948
] |
A model for the unidirectional movement of dynein is presented based on structural observations and biochemical experimental results available. In this model, the binding affinity of dynein for microtubule is independent of its nucleotide state and the change between strong and weak microtubule-binding is determined naturally by the variation of relative orientation between the stalk and microtubule as the stalk rotates following nucleotide-state transition. Thus the enigmatic communication from the ATP binding site in the globular domain to the far MT-binding site in the tip of the stalk, which is prerequisite in conventional models, is not required. Using the present
|
[
-0.022888355,
-0.020614235,
-0.004845883,
-0.0118521815,
-0.007464466,
0.036653474,
-0.020119278,
0.024881555,
-0.0025650742,
-0.035610054,
0.0124274,
0.012146479,
0.008226966,
0.006762164,
-0.007584861,
-0.01114988,
0.014393846,
-0.0017590992,
-0.0011119781,
-0.0056518586,
-0.009216877,
0.026580457,
-0.011564572,
-0.038258735,
0.0044211578,
0.01589209,
0.01147762,
-0.039435927,
-0.00064335874,
-0.012741764,
-0.011832115,
-0.007551418,
0.0006542277,
-0.029349532,
0.0013686527,
0.002949668,
0.009109859,
-0.0075581064,
0.012460843,
-0.009765341,
-0.0058090403,
0.011845493,
-0.0106549235,
-0.014768407,
-0.01716292,
0.0055281194,
0.024212696,
0.0016295078,
-0.009283762,
0.0031871132,
0.0017891978,
0.008226966,
-0.0070965937,
-0.00027653138,
-0.011377292,
-0.018286604,
0.014821915,
0.002847667,
-0.0059026806,
-0.014648012,
-0.012313694,
0.015076081,
-0.011089682,
0.0112100765,
-0.021898443,
-0.0034279022,
0.008280475,
0.011959199,
-0.005484644,
0.00079092575,
0.023945153,
0.013658101,
0.012139791,
0.0062170443,
0.05019118,
-0.030821022,
-0.022741206,
0.0021236273,
-0.020052392,
0.03197146,
0.000015402045,
-0.023276294,
-0.010106459,
0.026165763,
-0.011791984,
-0.013979153,
0.00666518,
0.010835515,
-0.020319937,
0.0004477175,
0.02120283,
0.035610054,
-0.0015467365,
0.01788529,
-0.010608104,
0.017096035,
-0.007290563,
0.03914163,
-0.020734629,
-0.025764449,
-0.0022055625,
0.014714898,
-0.0043576164,
-0.014768407,
-0.017430466,
0.0061635356,
0.015530906,
-0.029322779,
0.009410846,
-0.032560054,
-0.034432862,
0.019316647,
-0.0064076693,
-0.043475833,
0.018487262,
-0.00050582463,
-0.010079705,
0.0019814947,
-0.006334095,
-0.009029596,
0.0063441275,
0.038900837,
0.005103394,
-0.004899392,
0.034941193,
0.0026603867,
-0.030580234,
-0.013765118,
0.00051502144,
0.007745387,
0.013638034,
0.036011368,
-0.012708321,
0.011056239,
-0.033710495,
0.008655035,
-0.0059996652,
-0.023463573,
-0.0134908855,
-0.031864442,
-0.0028242571,
0.027878042,
-0.044278465,
0.0020567414,
0.01868792,
0.020667743,
0.03684075,
0.009805473,
0.011089682,
0.0046519144,
-0.0036887573,
-0.023838134,
0.009477732,
0.027008526,
-0.0032840976,
0.025162475,
-0.0075313523,
0.018192964,
-0.023450196,
-0.021430243,
-0.003855972,
0.0045616184,
0.014621258,
-0.025831334,
0.024159187,
0.013591215,
-0.01015328,
0.006280586,
-0.005280642,
-0.014755029,
0.002946324,
0.011591326,
-0.01973134,
0.029804356,
0.01669472,
0.013858758,
0.029964883,
0.013209965,
-0.03092804,
-0.012848781,
-0.006193634,
-0.006849116,
0.006902625,
0.005531464,
-0.007564795,
-0.018473886,
0.018955464,
-0.011263586,
0.009236943,
-0.015343625,
0.0016236552,
-0.007444401,
0.006538097,
0.012601303,
-0.6455292,
-0.014581126,
0.0016922132,
-0.03092804,
-0.0059695663,
0.014273451,
0.009103171,
0.008180145,
0.0031586867,
0.028092077,
-0.04459952,
-0.0051100827,
-0.01086227,
-0.02860041,
-0.031463128,
-0.014648012,
-0.00457834,
-0.021938575,
0.027690763,
0.011069616,
-0.004805752,
0.019102613,
-0.023062257,
0.0054110694,
0.0143670915,
-0.010808761,
0.017564237,
0.00007404478,
-0.005531464,
0.02722256,
-0.022540549,
0.036867507,
-0.012775207,
0.007765453,
0.035957858,
-0.012327071,
-0.0036419372,
0.021363357,
0.005056574,
0.0032339331,
-0.02314252,
-0.020748006,
-0.00030537593,
-0.0005079148,
-0.011758541,
0.016092747,
0.020560725,
-0.008086505,
0.006902625,
-0.015611169,
0.014487485,
0.0061969785,
-0.0248548,
0.0038994479,
0.0069561335,
-0.00006923736,
0.008039685,
-0.025817957,
0.029296024,
0.012748453,
0.0030182262,
-0.0016520817,
0.010139902,
-0.020707874,
-0.001248258,
0.012253497,
-0.019838357,
0.01831336,
0.0072838743,
-0.002279137,
0.008982777,
0.013939021,
0.0052906745,
0.016761607,
0.002698846,
0.024078924,
0.019437043,
0.004775653,
0.004183713,
0.017216431,
-0.0007311465,
0.0014907195,
-0.0052137556,
-0.008119948,
0.04682013,
0.013537706,
-0.021898443,
0.01987849,
0.004354272,
-0.009009531,
-0.0018009029,
0.0044746664,
-0.017738141,
-0.034218825,
-0.015691431,
0.027824534,
-0.029777603,
0.008534641,
0.017229808,
-0.013029373,
-0.006916002,
-0.0016361963,
0.022660943,
0.0035449527,
0.02722256,
0.021430243,
-0.013765118,
0.012307005,
0.04227189,
-0.026072124,
0.005023131,
-0.0054679224,
-0.02457388,
-0.012521041,
-0.008554706,
-0.037830666,
0.02219274,
0.0036553144,
0.011818739,
-0.027664008,
0.0012607992,
-0.00008203973,
0.0015626218,
0.001485703,
-0.0012783568,
0.013925645,
0.01783178,
-0.02969734,
0.003732233,
0.0071166595,
-0.0005313249,
0.010935845,
0.04866618,
0.011504374,
0.03724207,
0.016400423,
0.0068089846,
0.005330806,
0.002244022,
-0.042566188,
-0.026928263,
0.0033643607,
-0.007999553,
-0.0156513,
0.0064143576,
-0.027169053,
-0.030714005,
-0.006360849,
0.0059093693,
-0.018326737,
0.0072437427,
-0.0007679337,
-0.0053609046,
0.022687698,
-0.003571707,
-0.008507886,
-0.022808092,
-0.030526724,
0.0057154,
-0.0012156512,
0.0070832167,
-0.0012750125,
-0.037696894,
0.022165988,
-0.027008526,
-0.02461401,
-0.006748787,
-0.010494398,
-0.011992642,
-0.046124514,
0.01090909,
-0.014928932,
-0.027021904,
0.0030332755,
-0.014781783,
-0.0033827543,
0.0004435371,
0.018380245,
-0.0059026806,
-0.013183211,
-0.004317485,
-0.013638034,
-0.0024212697,
-0.019905243,
0.038071454,
0.013276851,
0.018433753,
0.013845381,
-0.0017356891,
0.009444289,
0.0012683239,
-0.0003672454,
-0.0040131537,
0.008802184,
0.007049774,
-0.0123805795,
0.033656985,
0.0031687196,
-0.013638034,
0.017229808,
0.009089794,
-0.005126804,
0.014567749,
-0.025028704,
0.0018243128,
0.0018828381,
-0.007618304,
-0.015771694,
0.026714228,
0.014179811,
0.011658212,
-0.027637254,
0.018808315,
-0.01669472,
0.0288412,
0.02798506,
-0.0021470373,
0.007424335,
-0.012373892,
-0.0022239562,
-0.0134306885,
0.0069761993,
0.0151563445,
0.0074109575,
0.0014865391,
-0.014112925,
-0.00408004,
0.006544785,
-0.020025639,
-0.005949501,
0.0037355775,
0.0023878266,
0.009805473,
0.012280251,
-0.0023660888,
0.005588317,
-0.0164138,
0.007471155,
0.050860036,
0.007698567,
-0.00036390108,
0.008835628,
-0.0024630732,
-0.011564572,
0.025737694,
0.011771918,
0.029590322,
0.011317094,
0.0027623877,
-0.0049896883,
-0.018607657,
0.009778718,
-0.011437489,
-0.0029262581,
-0.007337383,
-0.014567749,
0.01783178,
0.014380468,
0.029135497,
0.020119278,
-0.0012407334,
0.020507216,
0.022888355,
-0.020654365,
-0.0023878266,
-0.002959701,
0.012434089,
-0.008333983,
-0.016494062,
0.009036285,
-0.019008972,
0.01328354,
0.030473216,
-0.007464466,
0.027169053,
-0.0083741145,
0.021323225,
0.011002731,
0.03767014,
0.028894708,
-0.01788529,
-0.03264032,
0.019758094,
0.008481132,
-0.014032662,
-0.020119278,
-0.008487821,
0.014888802,
-0.007424335,
-0.008889136,
-0.0051201154,
-0.013009307,
0.0009773702,
-0.0019463797,
-0.024921685,
-0.004832506,
0.030312689,
-0.028734183,
0.013858758,
-0.016453931,
0.014821915,
-0.006280586,
-0.016012484,
-0.0017340169,
0.036492947,
-0.004193746,
0.007999553,
0.0012106348,
-0.0027975028,
-0.01788529,
-0.00012990496,
-0.002901176,
-0.0042472547,
-0.02651357,
-0.0020316592,
0.009236943,
-0.0068558045,
0.024105677,
0.049254775,
-0.032265756,
0.0038526277,
-0.011203388,
-0.0006099158,
-0.0010149935,
0.04625829,
0.005160247,
0.009618192,
0.009317205,
-0.026366422,
0.024640765,
0.0076517467,
-0.029483303,
0.025737694,
0.012059527,
0.0104342,
-0.012969176,
-0.007043085,
-0.005895992,
-0.0048927036,
0.021095812,
0.003718856,
-0.017952176,
0.0090162195,
0.015544283,
0.011551195,
-0.001065994,
0.016025862,
0.0288412,
-0.010133213,
0.007457778,
-0.0051736245,
0.015731564,
-0.019062482,
-0.01844713,
0.0009305501,
0.0056552025,
0.016467309,
0.015678056,
-0.028199095,
-0.038981102,
-0.008126637,
0.015624546,
-0.0074176462,
0.007752076,
0.015102836,
-0.010661612,
0.012206676,
0.0131899,
-0.008400869,
-0.0053575607,
0.016667966,
-0.0044512567,
-0.0021252995,
-0.007979488,
0.05131486,
-0.03724207,
-0.021992084,
-0.01328354,
0.017711386,
0.012032773,
-0.00039859815,
-0.0077988957,
0.011925756,
-0.013377179,
-0.005929435,
-0.021657655,
0.021403488,
-0.004558274,
0.026165763,
-0.003889415,
-0.028948218,
-0.00716348,
-0.01399253,
-0.016855247,
-0.00659495,
-0.031222338,
-0.036974523,
-0.0042806976,
0.024774536,
0.024734406,
-0.0042472547,
-0.010166656,
0.006066551,
0.030205673,
-0.041710045,
0.010073016,
-0.018059192,
-0.025269493,
-0.0067956075,
0.014768407,
0.0075246636,
0.011604704,
0.002402876,
-0.008026307,
0.032560054,
0.0002754863,
0.018701298,
-0.011899002,
-0.01308957,
0.010514463,
0.031489883,
0.023517082,
-0.012480909,
-0.009618192,
0.015035951,
-0.027503481,
-0.0023276294,
-0.0034646895,
0.0017039183,
-0.013049439,
-0.008140014,
0.018540772,
-0.008655035,
-0.0052706087,
0.00462516,
-0.031516634,
0.00777883,
-0.008527952,
0.0124073345,
0.015249985,
0.010073016,
0.0032506548,
0.00024789586,
-0.009832228,
-0.008400869,
-0.017015772,
0.02334318,
0.012313694,
-0.017390333,
0.028520148,
-0.013524328,
-0.018032439,
-0.008695167,
-0.001495736,
-0.015196476,
0.024975196,
-0.0007395072,
-0.017350202,
-0.0030800956,
-0.0051201154,
-0.02129647,
-0.011243519,
-0.013778496,
-0.00365197,
-0.0031703915,
-0.020360067,
0.009002842,
0.010106459,
0.0068558045,
-0.03197146,
-0.011183322,
0.025510281,
-0.021764671,
0.016119502,
-0.01057466,
0.005083328,
-0.010032885,
-0.026848,
-0.002096873,
-0.030392952,
-0.013484198,
0.004819129,
0.01702915,
0.008099882,
0.04417145,
0.0072972514,
0.018487262,
0.030339444,
-0.005427791,
-0.011638147,
0.0036419372,
0.003163703,
-0.035984613,
0.000038302627,
0.023985283,
0.013263474,
0.0078791585,
0.008882447,
0.0010057967,
0.030339444,
-0.0021921853,
-0.013450754,
0.008146702,
-0.054525387,
-0.012541106,
0.011216765,
-0.01081545,
-0.021216208,
-0.035021458,
-0.02860041,
0.011016107,
0.0009715177,
-0.0029212416,
-0.007471155,
0.014594503,
-0.0023175965,
0.042485923,
-0.006280586,
-0.0033024913,
-0.013424,
0.0009623209,
-0.0037890861,
0.011116437,
0.028734183,
-0.0066484585,
-0.0056083826,
0.017096035,
-0.0021637587,
-0.000986567,
-0.01835349,
0.0055281194,
-0.015918843,
-0.0044512567,
-0.02509559,
-0.0042806976,
-0.02969734,
-0.027476728,
-0.038071454,
-0.008113259,
-0.0008247867,
-0.0033259012,
0.01138398,
-0.011604704,
-0.020694498,
0.028573656,
-0.0060598627,
0.013196588,
-0.00049495563,
0.023369933,
0.02902848,
-0.02632629,
-0.017577615,
-0.016440554,
-0.011872247,
0.013638034,
0.02522936,
0.0016127862,
-0.021002172,
-0.03202497,
-0.00093222223,
0.00967839,
0.0043709935,
-0.020600857,
0.00042388937,
0.0052204444,
0.020079147,
0.0041235154,
0.015958976,
0.0011119781,
0.029857865,
-0.0047020786,
0.00825372,
-0.023530459,
-0.002449696,
-0.034379352,
0.020119278,
0.0069226907,
0.027276069,
0.0015576053,
-0.008895825,
0.0036486257,
0.0069628223,
0.011551195,
0.024453485,
-0.011758541,
0.021604145,
0.0040298756,
0.0025199263,
0.0006696951,
0.00716348,
-0.017457219,
-0.008688479,
0.012266874,
0.03767014,
-0.020266427,
-0.009009531,
0.02897497,
-0.003444624,
-0.002292514,
-0.024480239,
-0.016373668,
-0.0055950056,
-0.04922802,
0.015597791,
0.021791426,
0.01920963,
0.0054712663,
-0.027249316,
-0.01844713,
0.007852404,
-0.014741652,
0.0023159243,
0.005227133,
-0.034941193,
-0.03467365,
-0.0012189955,
0.040639874,
0.006390948,
-0.0009614848,
-0.02660721,
-0.010868958,
0.041041188,
-0.012848781,
0.018674543,
0.023958528,
-0.0023660888,
-0.030232426,
0.0038860708,
-0.006447801,
-0.0408004,
0.008153391,
0.00069059693,
-0.023369933,
0.022487039,
-0.004136893,
0.040211804,
0.025871465,
-0.003061702,
0.021470373,
0.0056552025,
0.014648012,
0.0045382082,
-0.007745387,
0.0048492276,
-0.02044033,
-0.008313918,
0.0016420488,
-0.0056652357,
-0.014648012,
0.008688479,
-0.024132432,
-0.004521487,
-0.026914885,
-0.00915668,
-0.031489883,
-0.0010935845,
-0.011818739,
-0.017443843,
0.033095144,
-0.032854352,
-0.0012281924,
0.017524106,
-0.00664177,
0.0022607434,
-0.0069427565,
-0.03264032,
0.008280475,
0.0068156733,
-0.01512959,
0.0053341505,
0.020654365,
-0.0052538873,
-0.032961372,
0.013651412,
-0.0042940746,
0.04229864,
-0.00773201,
-0.0041870573,
-0.0018794938,
0.009069728,
-0.042432416,
-0.018995596,
0.009899113,
0.007618304,
-0.008441,
-0.0094376,
0.00095981266,
0.0033727214,
0.009785407,
-0.0016587703,
0.007551418,
-0.0023711051,
0.04377013,
-0.01708266,
0.00630734,
0.033175405,
-0.025951728,
-0.0027122232,
0.015530906,
-0.025055457,
-0.0067755417,
0.009932556,
0.007317317,
0.003799119,
0.0045081098,
0.000782983,
0.0072437427,
0.027062034,
0.026955018,
-0.030874532,
-0.00834736,
0.003876038,
0.0066183596,
-0.028439885,
0.00730394,
-0.006882559,
0.008688479,
0.01512959,
-0.018246474,
-0.025831334,
-0.002991472,
-0.006334095,
0.03419207,
0.021028927,
0.011056239,
0.016427176,
0.024734406,
-0.016948886,
-0.0066484585,
-0.002528287,
-0.05591661,
-0.015089459,
0.009497798,
-0.013196588,
0.033228915,
-0.008273786,
0.008441,
-0.016681343,
0.024533749,
0.0068290504,
0.002618583,
-0.028707428,
-0.00006500474,
0.025122344,
-0.019838357,
0.012099659,
0.0066752126,
-0.014915556,
-0.013203276,
0.010193411,
0.0067855744,
-0.031837687,
0.0011738476,
-0.0048157847,
-0.00777883,
0.0035115096,
0.007317317,
-0.0026252714,
-0.023637477,
0.0070230193,
0.1774349,
-0.020574102,
0.002356056,
0.02785129,
-0.006578228,
-0.0069226907,
-0.020895155,
-0.004417814,
0.0042104675,
-0.017564237,
0.008360737,
0.03025918,
0.0039863996,
-0.0027490105,
0.014995819,
0.008006242,
-0.0188752,
-0.026848,
-0.030954795,
0.006882559,
0.0020701187,
-0.011343849,
0.008949333,
0.0036987902,
0.036974523,
-0.013925645,
-0.01868792,
-0.014139679,
-0.029001726,
0.0002280391,
-0.026740983,
-0.018019062,
0.004635193,
-0.0056786127,
0.017149545,
-0.0025232704,
-0.009149991,
0.005250543,
0.0075112865,
0.00830054,
0.0204002,
0.00022845715,
-0.00228917,
-0.014741652,
0.021885065,
0.001575999,
-0.013390557,
-0.03044646,
-0.003367705,
-0.010012819,
-0.047141183,
-0.017243184,
0.01076863,
0.000737417,
-0.0032406219,
-0.009444289,
0.007839028,
0.030606987,
0.010474332,
0.009377403,
-0.044893816,
0.0038593165,
-0.014648012,
0.01792542,
-0.018019062,
0.019704586,
-0.016373668,
-0.013912267,
0.042459168,
-0.009143302,
0.005702023,
-0.023744494,
0.0022774648,
0.015343625,
-0.015022573,
-0.012915667,
0.033764,
0.01740371,
0.04026531,
0.026366422,
-0.0009455994,
0.014179811,
-0.024801292,
-0.025630677,
0.00034216317,
-0.0008695167,
0.024092302,
-0.01114988,
-0.0057990076,
0.007130037,
0.013015996,
-0.01380525,
-0.0056518586,
-0.015544283,
0.017042527,
0.0073306947,
-0.008394181,
-0.017617745,
-0.01868792,
-0.007551418,
-0.014246697,
0.058110468,
0.02030656,
0.0119123785,
-0.013644723,
0.013276851,
-0.0030081933,
0.013270162,
-0.005223789,
-0.022112478,
0.007598238,
-0.012166545,
0.0062872744,
-0.016453931,
-0.006621704,
0.025483528,
0.000106390384,
-0.005976255,
0.018460508,
-0.0044211578,
0.0010919123,
-0.02096204,
0.018714674,
0.004073351,
0.0021788082,
0.01323003,
-0.00977203,
0.009056351,
-0.0009614848,
-0.019383533,
-0.0015559333,
0.0000798973,
0.0008406721,
0.009129926,
-0.008200211,
-0.00858146,
-0.002946324,
-0.047462232,
-0.00825372,
-0.020921908,
0.0104208235,
0.00782565,
0.011236831,
0.011631458,
0.012166545,
-0.0075447294,
0.033095144,
0.020881778,
-0.007872471,
-0.01432696,
0.014648012,
-0.0043643047,
0.011959199,
-0.007859093,
0.000260646,
-0.011838804,
-0.018781561,
-0.024012038,
-0.004782342,
0.00308344,
-0.041469257,
0.002867733,
0.02945655,
0.010287051,
0.011236831,
0.012628058,
-0.1687665,
0.020493839,
0.023731116,
-0.014099548,
0.018540772,
0.0033392785,
0.0052438546,
0.013939021,
-0.010661612,
-0.012273562,
0.004360961,
0.009129926,
-0.036466192,
-0.013216654,
0.0019146089,
0.017952176,
-0.010414135,
0.009825539,
0.02390502,
-0.008474443,
0.0035984614,
-0.030285936,
0.009230254,
-0.022901732,
0.011731787,
0.030660497,
-0.000009445021,
0.0236241,
-0.00953793,
-0.017042527,
0.017002396,
-0.0051234597,
0.044572763,
-0.009785407,
0.054899946,
0.023597345,
-0.00038271275,
0.0047723087,
-0.0076249926,
0.016721474,
0.020493839,
0.029483303,
0.014955687,
-0.013678166,
0.005568251,
0.023182653,
-0.01607937,
0.010494398,
0.018794937,
-0.024038792,
0.03448637,
0.0031938017,
0.013791872,
0.020560725,
0.0072036115,
0.024734406,
0.003504821,
0.027530236,
-0.008273786,
-0.009825539,
-0.0072638085,
-0.012367203,
0.016387045,
-0.0047990633,
-0.014380468,
-0.0064578336,
-0.010634858,
0.008976088,
-0.027449973,
0.0072704973,
-0.0164138,
-0.0033994757,
-0.010942533,
-0.02310239,
0.018299982,
0.010501086,
-0.0082871625,
0.0051301485,
-0.01195251,
-0.0014806866,
-0.03684075,
0.022714451,
-0.02547015,
-0.024493616,
-0.00030809318,
-0.0023175965,
-0.0061702244,
0.008166769,
-0.00057187444,
0.022754584,
0.011270274,
-0.027396465,
0.024306336,
-0.018340113,
0.018768184,
0.022941863,
0.013243408,
-0.0061200596,
0.026098877,
0.0035115096,
0.009029596,
-0.0123805795,
-0.008869071,
0.04221838,
0.02841313,
0.011517752,
0.003912825,
-0.004819129,
0.046124514,
-0.003345967,
-0.012594615,
-0.010313805,
0.011798672,
0.0140460385,
-0.013250097,
0.029804356,
-0.0019129367,
0.012099659,
-0.018473886,
-0.007885847,
0.05725433,
-0.004130204,
0.001745722,
0.003061702,
0.007859093,
-0.03662672,
-0.13580513,
-0.035048213,
0.024506994,
-0.005541497,
0.007718633,
-0.0049261465,
-0.012119725,
0.023543837,
-0.006882559,
0.03724207,
-0.034352597,
-0.0036686915,
0.0004092581,
0.0044612894,
0.003514854,
-0.010367314,
0.026005238,
-0.01702915,
-0.03836575,
0.01792542,
-0.008762053,
0.002302547,
-0.011243519,
0.009424224,
0.018139455,
-0.009136613,
-0.009444289,
0.031489883,
0.019557437,
0.0045549297,
0.0060297637,
-0.012206676,
0.010253608,
-0.020253051,
-0.015009196,
-0.0010392397,
-0.015062705,
-0.012601303,
0.0377504,
-0.006507998,
-0.00024894095,
-0.00013398082,
0.022232873,
0.009999442,
-0.016882,
-0.014353714,
-0.014072794,
0.017577615,
-0.01831336,
0.013497574,
-0.019931998,
0.0026486816,
-0.047167934,
-0.0010175017,
0.006337439,
-0.012748453,
-0.01589209,
-0.0062103556,
-0.0063441275,
0.003118555,
-0.020921908,
-0.0057990076,
0.007444401,
0.010715121,
0.02632629,
-0.016440554,
-0.006263864,
-0.004872638,
0.03585084,
-0.025751071,
0.000328786,
0.015316871,
-0.007317317,
0.0049729664,
-0.025028704,
-0.009999442,
-0.020814892,
-0.0048793266,
-0.0020350034,
0.00084485253,
-0.018821692,
-0.024159187,
0.012253497,
-0.033282425,
0.025496906,
-0.0027740926,
-0.006099994,
-0.003799119,
0.037402596,
-0.0022239562,
-0.004467978,
0.0315969,
0.0030433084,
-0.02068112,
0.0017172955,
0.010996042,
-0.0047087674,
-0.011370603,
0.009143302,
0.013163145,
-0.028573656,
-0.005237166,
-0.037696894,
0.024921685,
-0.0078055845,
0.0035315754,
0.009798784,
-0.024012038,
0.017617745,
0.017430466,
-0.018848447,
0.006889248,
-0.004852572,
-0.017510729,
-0.0030416362,
-0.017537482,
-0.006698623,
-0.03700128,
0.02187169,
-0.016467309,
0.0038693494,
0.03424558,
-0.011263586,
-0.008066439,
0.012119725,
0.03761663,
-0.026674097,
-0.028734183,
-0.035503034,
0.013383868,
0.002165431,
0.009183434,
0.010447578,
-0.031516634,
0.016708098,
0.0054612337,
0.006263864,
-0.0021637587,
-0.02106906,
0.023356557,
0.020814892,
0.04278022,
-0.021497129,
-0.042111363,
-0.016106125,
-0.0223934,
-0.012621369,
0.009511175,
-0.011885624,
-0.0024680896,
0.009765341,
-0.018514017,
0.03467365,
0.014982441,
0.0027038625,
-0.039971013,
-0.026874755,
0.007932668,
0.0011930772,
-0.008594838,
-0.017002396,
-0.0028158964,
0.028520148,
0.017965553,
-0.0065046535,
0.013912267,
-0.0048425393,
0.013102948,
-0.042566188,
0.010353937,
-0.008260408,
-0.04055961,
-0.006079928,
0.010347249,
0.000442283,
-0.008166769,
0.00048366867,
-0.016266651,
-0.012039462,
0.0033710494,
-0.00032063428,
0.019182876,
0.009036285,
0.0011320439,
-0.020600857,
-0.008982777,
0.019437043,
0.0017758206,
0.009370714,
0.024025414,
0.008260408,
-0.02058748,
0.008527952,
0.019530682,
0.004521487,
0.016922133,
-0.020855023,
0.009056351,
-0.013484198,
0.00008094239,
-0.0016161306,
-0.0014020957,
-0.0023326457,
-0.000861156,
0.011183322,
-0.032131985,
0.006079928,
0.051903456,
-0.045375396,
-0.019249761,
-0.014260074,
-0.01978485,
-0.0005526447,
-0.0034680339,
-0.015678056,
0.011644835,
-0.032506548,
0.010133213,
0.0015550972,
-0.046178024,
0.016681343,
0.020253051,
0.002314252,
0.027503481,
0.007892536,
-0.0051067383,
0.013250097,
0.0196377,
0.03178418,
-0.009330583,
0.029189005,
-0.015785072,
0.031222338,
0.00092135323,
-0.01892871,
-0.014741652,
-0.0013636362,
-0.014300205,
-0.024734406,
0.013096259,
-0.014728275,
0.0797815,
0.028466638,
0.010193411,
0.03306839,
-0.034085054,
0.01408617,
0.008561395,
0.016734852,
-0.003026587,
-0.03467365,
-0.011959199,
0.0056284484,
0.0039964323,
-0.016587703,
-0.012126413,
0.033469703,
-0.03333593,
0.0055281194,
-0.017724764,
-0.026098877,
0.010073016,
-0.029242516,
-0.0053207735,
0.011317094,
-0.011417423,
0.024226073,
0.006691934,
0.030821022,
0.005230477,
-0.027771026,
0.008186834,
0.011798672,
-0.048131093,
-0.015865335,
0.0021838245,
0.0048559164,
-0.03627891,
-0.0071032825,
0.0042572874,
-0.003809152,
0.010808761,
0.0014330304,
-0.0051301485,
0.007049774,
-0.008106571,
-0.0028727495,
-0.0020567414,
-0.023075635,
-0.021002172
] |
The inflammasome is a proteolysis complex that generates the active forms of the proinflammatory cytokines interleukin (IL)-1β and IL-18. Inflammasome activation is mediated by NLR proteins that respond to microbial and nonmicrobial stimuli. Among NLRs, NLRP3 senses the widest array of stimuli and enhances adaptive immunity. However, its role in antitumor immunity is unknown. Therefore, we evaluated the function of the NLRP3 inflammasome in the immune response using dendritic cell vaccination against the poorly immunogenic melanoma cell line B16-F10
|
[
-0.04191967,
0.0030943993,
-0.018806068,
-0.021931658,
-0.024991585,
0.015339028,
-0.010552148,
0.0045669065,
-0.015811807,
-0.013960091,
0.019646563,
-0.008700433,
-0.0012837243,
0.015719878,
0.009882379,
-0.00024870108,
0.042786434,
0.012594287,
-0.0021948074,
0.014498534,
-0.029627439,
-0.0041171107,
0.0057685515,
-0.002204657,
-0.005748852,
0.018438352,
0.0005536266,
-0.06056815,
-0.0030632091,
-0.013152429,
-0.002618338,
-0.0031584215,
-0.015772408,
0.0037526775,
0.005023269,
-0.019751625,
0.040763993,
-0.028681882,
0.0098167155,
-0.003493306,
0.019856688,
0.0007473344,
0.0022259976,
-0.0066845594,
-0.025333036,
-0.008713566,
0.0069209486,
-0.011931085,
-0.032201454,
-0.0045636236,
0.024637,
-0.014826852,
-0.015115771,
-0.006136268,
-0.01051275,
-0.024715796,
0.0012558172,
-0.014813719,
0.014485401,
-0.0341451,
-0.02275902,
-0.0024525372,
-0.010814803,
0.042261124,
0.015549152,
0.010683475,
0.011858854,
0.020670917,
0.005765268,
-0.008818628,
0.060305495,
0.032411575,
-0.009153512,
0.0018779803,
0.012712482,
-0.014682392,
-0.01751906,
0.0033586957,
-0.0037461112,
0.011727528,
0.006349675,
-0.012016447,
0.0009480189,
0.030126482,
0.016954353,
-0.011661864,
-0.0009513021,
0.004987154,
-0.0030418686,
-0.010755706,
-0.0010686759,
0.018517148,
0.024334949,
0.021774065,
-0.025727017,
0.003179762,
-0.0008536274,
0.01275188,
-0.0014864608,
-0.025818946,
-0.009055017,
-0.004297686,
-0.007978133,
-0.01462986,
-0.020762846,
-0.009626291,
-0.0012812619,
-0.007223001,
0.024032895,
0.023717709,
0.006192082,
0.015260232,
0.008733265,
-0.050061963,
0.019909218,
-0.012856943,
0.018753538,
-0.020263802,
-0.0093899015,
-0.004445429,
0.01313273,
0.038032386,
0.010072803,
-0.023901567,
0.03834757,
0.015798673,
0.0034473415,
-0.012371032,
-0.02862935,
-0.004790163,
0.0017039716,
0.034722935,
0.016914956,
-0.02516231,
-0.012725615,
0.018004972,
-0.008831761,
-0.017571593,
-0.008825194,
-0.0012000032,
0.0011803041,
0.036246333,
-0.022588294,
-0.0055288794,
0.00045472075,
0.010381423,
0.044493686,
-0.000025431838,
-0.0057718344,
0.024400612,
-0.005706171,
-0.02857682,
-0.00034904332,
-0.01824136,
0.0048689595,
0.030940711,
0.0071901693,
0.04483514,
-0.012397297,
-0.015982531,
-0.006349675,
-0.02093357,
0.0087201325,
0.0052826405,
0.002601922,
0.02160334,
0.01457733,
0.013224659,
-0.01616639,
0.009416167,
-0.004826278,
0.014367206,
0.0029909792,
0.026239194,
-0.028471757,
-0.002582223,
0.01779485,
0.0041532256,
-0.0068815504,
-0.018779803,
-0.0060903034,
-0.004340367,
0.01698062,
-0.01602193,
-0.02805151,
-0.019252582,
0.041683283,
-0.016770495,
0.0028662183,
-0.018438352,
0.020368863,
0.018884866,
-0.001738445,
-0.027893918,
-0.62364703,
-0.026869565,
0.044519953,
0.008982787,
-0.016035063,
0.026252326,
-0.0019173785,
-0.024111692,
-0.012692783,
0.021563942,
-0.019856688,
-0.0015250383,
0.030441668,
-0.01625832,
-0.014721789,
-0.024361214,
-0.017479664,
-0.0048952247,
0.005873613,
-0.0070719747,
-0.0067502228,
-0.0045669065,
-0.0025477496,
-0.0007842702,
-0.041551955,
0.024400612,
0.033829913,
-0.027972713,
-0.008306451,
0.023323728,
-0.009048451,
0.021104297,
-0.0015045183,
-0.0030566428,
0.045728166,
-0.0030057535,
-0.0061986484,
0.035195716,
0.022312507,
0.0377172,
-0.020907305,
-0.017164478,
0.007794275,
-0.009593459,
-0.017374601,
0.015076374,
0.0027414572,
0.024137957,
0.002779214,
-0.014091419,
0.014196481,
0.01501071,
-0.006638595,
0.00427142,
0.005903162,
0.010525883,
0.031413488,
-0.0006049264,
0.002260471,
-0.004389615,
-0.013684304,
0.003801925,
-0.009330804,
-0.029075863,
-0.008339283,
0.008890858,
-0.025227973,
0.001542275,
0.0034965891,
0.013270623,
0.012016447,
0.024032895,
-0.011346678,
-0.006934081,
-0.0059918077,
0.016914956,
-0.022995409,
0.015220834,
0.0024311966,
0.01176036,
-0.007774576,
-0.003851173,
-0.027578732,
-0.0034834566,
0.0010752422,
0.012023014,
0.018595945,
0.027683794,
-0.00834585,
0.0007042426,
0.017492795,
-0.0011277732,
-0.021183092,
-0.041499425,
-0.025805814,
0.017361468,
0.0027759308,
0.016337115,
0.014485401,
-0.01698062,
-0.0029778464,
-0.0036771642,
0.019226316,
-0.023560116,
0.03585235,
0.001678527,
-0.03892541,
0.0018320158,
0.043574397,
-0.012594287,
0.008148858,
0.0065105506,
0.00097592594,
-0.015811807,
0.009547494,
-0.017505929,
0.013264057,
0.013021101,
0.0075710188,
-0.010926431,
0.019699095,
-0.016284585,
0.02059212,
-0.0030402269,
0.01529963,
0.003723129,
0.012292235,
-0.00026347538,
-0.007630116,
-0.018412087,
0.010125334,
0.001092479,
0.014117684,
-0.02444001,
0.012705916,
0.024466274,
0.0297325,
0.010315759,
0.012784712,
-0.04123677,
-0.027526202,
-0.028261634,
0.010046538,
-0.012016447,
-0.014301542,
0.0029302402,
-0.024032895,
0.010447087,
0.021340685,
0.03354099,
0.008805495,
0.0049050744,
-0.012462961,
-0.0075184875,
0.029075863,
0.008385248,
-0.0050757998,
-0.017505929,
-0.007728611,
-0.022982277,
-0.0035753855,
0.0057291533,
-0.013067066,
0.006556515,
-0.018884866,
-0.014787453,
0.008877725,
-0.013461048,
0.019186918,
-0.04622721,
-0.00875953,
0.0040612966,
-0.02747367,
0.019620297,
0.010177866,
0.02001428,
-0.013198393,
-0.0034867397,
0.003637766,
-0.0064284713,
-0.013139296,
-0.01101836,
0.014038888,
0.0019420023,
0.0154178245,
0.021774065,
0.017860511,
0.0063266926,
0.00760385,
0.030231543,
-0.012147775,
0.017492795,
-0.002774289,
0.038715288,
-0.014485401,
-0.013618641,
0.017243274,
0.01181289,
0.0073017976,
0.023809638,
-0.012607421,
-0.018490883,
0.015286497,
-0.028314166,
-0.011878554,
-0.013139296,
0.013119597,
-0.028892005,
0.028892005,
0.0008577314,
0.006966913,
0.015312763,
-0.0032979567,
-0.010703174,
0.0037296952,
0.023757108,
0.009114115,
-0.0066188956,
0.013264057,
-0.021353818,
0.007223001,
-0.005722587,
0.0061658164,
-0.02169527,
-0.012962004,
-0.0018763387,
0.008595372,
0.012128076,
0.0053187553,
-0.028760677,
-0.01818883,
0.014997577,
0.020946704,
0.03645646,
0.0074987886,
-0.0012016448,
0.0026002803,
-0.00040855102,
0.023376258,
-0.016862424,
-0.017729186,
-0.005167729,
-0.0017696354,
0.018412087,
-0.0061329845,
-0.010775405,
0.023034807,
0.019896084,
0.0014725073,
0.025333036,
-0.0148399845,
-0.00964599,
-0.01876667,
0.0077680093,
-0.019252582,
-0.022548897,
-0.0043535,
0.0063102767,
0.063930124,
0.017650388,
0.015076374,
-0.009974308,
0.011070891,
-0.014459135,
0.014774321,
-0.014327808,
0.008404947,
-0.014800586,
0.0012714124,
-0.0037658103,
-0.04110544,
0.0027069838,
0.013697437,
-0.029679969,
-0.008450911,
0.018556546,
0.014826852,
0.014249012,
0.0042090397,
0.008070062,
0.0023589665,
-0.034565344,
0.03425016,
0.009192911,
-0.0051742955,
-0.025438096,
-0.04701517,
0.012883208,
0.00095786847,
0.0097247865,
0.0019157369,
0.019541502,
0.003906987,
0.039083004,
0.01428841,
0.0011154612,
0.036351394,
-0.023599515,
0.017374601,
-0.0027972714,
0.01029606,
-0.002304794,
-0.013185261,
-0.00020817429,
0.031965062,
0.0070391432,
0.0040021995,
-0.022207446,
-0.02313987,
0.0003396042,
0.017505929,
0.001071959,
0.004015332,
-0.019410174,
0.01029606,
-0.006267595,
0.017190743,
0.011005227,
0.007124506,
-0.000097572076,
-0.02362578,
-0.034276426,
0.03800612,
0.003690297,
0.009212609,
0.008063496,
0.0135004455,
0.02353385,
-0.005748852,
-0.0029121828,
-0.016323984,
-0.021931658,
0.0147480555,
-0.03296315,
-0.01929198,
0.0118260225,
0.0063792234,
0.010696609,
0.012962004,
0.01905559,
0.02805151,
-0.023336861,
-0.0077811424,
0.008588805,
0.012876641,
0.010755706,
0.032464106,
0.02015874,
0.022443835,
-0.008260487,
-0.0036771642,
0.008010965,
-0.0016095801,
-0.027736325,
0.0075578857,
0.0031272313,
-0.0017154628,
0.0062052147,
-0.016205788,
-0.022430701,
-0.008726698,
0.026212929,
0.015168303,
0.0035556864,
-0.006523683,
-0.007965,
0.004058013,
-0.006103436,
-0.009954609,
-0.015627949,
0.00065909885,
0.0115962,
0.0017942592,
-0.0037329784,
0.044546217,
-0.017689787,
-0.029548641,
-0.046647456,
0.008667601,
-0.019410174,
-0.0035228548,
0.0034801734,
0.004822995,
-0.01867474,
-0.012364465,
-0.00935707,
0.013658038,
-0.003457191,
-0.025963407,
-0.008227655,
-0.02776259,
-0.00014558862,
-0.02891827,
0.0043502166,
0.018924262,
-0.019502103,
-0.042156063,
0.015339028,
-0.0032864655,
0.0038807215,
0.017295804,
0.00731493,
0.022719622,
0.018792937,
-0.002485369,
-0.014393471,
0.0056996047,
-0.05394925,
0.022837816,
0.001168813,
-0.007308364,
-0.03419763,
-0.027027158,
-0.00839838,
0.0011630674,
-0.016573505,
-0.005558428,
0.007978133,
-0.020657783,
0.048512302,
0.020986103,
0.013841897,
-0.0039792173,
-0.02886574,
-0.020395128,
-0.04333801,
-0.04037001,
-0.003368545,
-0.02236504,
-0.023993498,
0.010460219,
0.013270623,
0.010433953,
-0.002160334,
0.022772154,
0.0115962,
-0.0046325703,
-0.018004972,
-0.00010690863,
0.025727017,
-0.020697182,
0.01828076,
0.0006673068,
-0.018425219,
-0.029338518,
-0.010433953,
0.027631262,
0.015798673,
-0.004176208,
0.0021028784,
-0.013053933,
0.008385248,
-0.01443287,
0.003401377,
-0.00008479845,
0.0096656885,
0.013776233,
-0.017650388,
-0.026344255,
-0.014130817,
-0.011655297,
0.012640252,
-0.00060123275,
-0.020434527,
-0.010197564,
0.016586637,
-0.012705916,
-0.014682392,
0.014130817,
-0.024019763,
-0.017991839,
0.021498278,
-0.012653385,
0.0044355793,
-0.020697182,
-0.005525596,
-0.02665944,
-0.025713885,
-0.021393217,
-0.018254494,
0.008667601,
-0.0113072805,
0.052373324,
0.017650388,
0.029443579,
-0.006681276,
0.014892516,
0.021760933,
0.004172925,
-0.0025871478,
-0.009737919,
0.021852862,
-0.0040711462,
0.027368609,
-0.0032339348,
-0.01022383,
0.01986982,
-0.020421395,
0.017860511,
-0.005164446,
-0.011267882,
-0.02559569,
-0.023849037,
-0.008221089,
-0.04333801,
0.02396723,
-0.002232564,
-0.013053933,
-0.031571083,
0.009600026,
0.021865994,
-0.0060771704,
0.01152397,
0.016704831,
0.022246843,
-0.03632513,
0.019094989,
-0.017348336,
0.014551064,
-0.0066123293,
-0.0040021995,
0.010282927,
0.008063496,
0.0021554092,
0.005640507,
-0.0010087577,
0.007288665,
-0.023126736,
-0.0011409059,
0.0076235496,
-0.0030123198,
-0.0021554092,
-0.0022358473,
-0.020487059,
-0.009107548,
-0.008884291,
-0.014143949,
-0.027946448,
0.016442178,
-0.00059220404,
-0.0038117748,
0.017217008,
-0.007091674,
-0.013447915,
0.026830167,
0.013270623,
0.014446002,
-0.0059425603,
0.00275459,
0.02881321,
0.009271707,
-0.016652301,
0.013441348,
-0.0023441922,
-0.0040777125,
0.015036975,
0.029863827,
-0.029785031,
-0.0297325,
0.0059524095,
0.007163904,
-0.0022949446,
-0.012410429,
0.03170241,
0.008549407,
0.03440775,
-0.020565854,
-0.025727017,
-0.008339283,
0.011839156,
-0.029469846,
0.013434783,
0.0042418716,
0.001963343,
-0.015286497,
-0.0155097535,
0.0011745585,
0.006986612,
0.0045307917,
-0.02665944,
0.009212609,
-0.02742114,
0.007866505,
-0.019305112,
0.006802754,
0.020670917,
0.0049280566,
0.025897743,
0.01118252,
0.027841387,
0.012745314,
0.0058768964,
-0.0016719606,
0.036745377,
-0.0024968602,
-0.0017597858,
0.012850376,
0.009455565,
0.0043994645,
-0.01457733,
0.0012911115,
-0.022141783,
-0.018845467,
0.0095737595,
0.019449573,
-0.015903736,
-0.011517404,
0.014301542,
-0.029023333,
0.0009529437,
-0.027342344,
-0.009055017,
-0.002557599,
-0.020841641,
-0.00877923,
0.016560372,
-0.0033948105,
0.014642993,
0.003168271,
0.0035753855,
-0.0056043924,
0.011773492,
-0.051900547,
-0.006284011,
-0.005006853,
0.006142834,
0.0022867366,
-0.0070654084,
-0.020697182,
-0.014774321,
0.01929198,
-0.0060016573,
-0.032122657,
-0.00002588071,
0.0018221663,
0.03285809,
0.023783373,
-0.012817544,
0.012331633,
0.017886778,
0.0012443261,
0.008431212,
-0.011642165,
0.010663777,
-0.024111692,
0.009350504,
0.03921433,
-0.013145862,
-0.01390756,
0.022719622,
-0.004090845,
0.01593,
0.009488397,
-0.024492541,
-0.01371057,
-0.011858854,
0.00077195826,
0.014367206,
-0.020670917,
0.009672255,
-0.022443835,
-0.0017729185,
0.0022259976,
-0.022010455,
-0.0037165624,
0.0131655615,
0.011734094,
0.015798673,
-0.020132475,
-0.013828764,
0.0022982277,
-0.03643019,
-0.014314675,
-0.008470611,
-0.036115006,
0.041683283,
0.009232309,
0.009304539,
-0.022732755,
0.0039890665,
-0.030257808,
-0.028392961,
-0.01732207,
0.017059416,
-0.009797016,
0.020473925,
0.0021472012,
0.013086765,
-0.011077457,
0.0023031523,
0.0007153234,
-0.039293125,
-0.010059671,
-0.027893918,
0.018504016,
-0.0035852352,
-0.009416167,
-0.02357325,
0.059149813,
0.0010957621,
-0.020119341,
0.05494734,
-0.039976027,
-0.005203844,
-0.007774576,
-0.0039857836,
-0.014603595,
0.028209103,
0.024912788,
-0.019922351,
-0.0070325765,
-0.0016974052,
-0.00080971484,
0.0050528175,
0.0097247865,
0.014183348,
0.02352072,
-0.0048952247,
0.0036016512,
-0.050823662,
-0.015851205,
-0.027867652,
0.03256917,
0.013067066,
0.0072689657,
0.027342344,
0.0031928949,
-0.036167536,
-0.021183092,
-0.010650644,
-0.011806324,
-0.0023244931,
0.01058498,
-0.008930256,
-0.03272676,
-0.00056224497,
0.023126736,
-0.012502358,
-0.005597826,
-0.03522198,
0.013093331,
-0.0304154,
0.008582239,
0.011386077,
-0.0033028815,
0.0037001465,
-0.015995665,
-0.0118260225,
-0.022286242,
0.010558714,
0.010256662,
0.00308455,
-0.0010309193,
0.009055017,
-0.0032060277,
-0.015851205,
-0.005285924,
-0.008260487,
-0.025753282,
0.010453653,
0.18711513,
-0.03002142,
-0.008687301,
0.019305112,
0.00543695,
0.010709741,
-0.01022383,
-0.026567511,
-0.014170215,
-0.024505673,
0.017952442,
0.008634769,
0.00279563,
-0.0012853659,
0.018162565,
0.012226571,
0.0006701796,
-0.0020766128,
-0.027053423,
-0.01253519,
0.0060213567,
0.0010891957,
-0.009961176,
-0.006234763,
0.035195716,
0.012935739,
-0.013158995,
0.016875558,
0.007702346,
0.0006894683,
-0.027788855,
0.010814803,
-0.0024361212,
0.003473607,
0.0092388755,
0.0070457095,
-0.017886778,
-0.021590207,
0.015457222,
0.00068208115,
-0.0072689657,
-0.0031731958,
0.015838072,
-0.002854727,
0.007308364,
-0.0012648461,
-0.0006119031,
-0.012298801,
-0.014524799,
0.022995409,
-0.029863827,
0.0072689657,
0.009409601,
0.012200306,
0.0032864655,
-0.006874984,
-0.0059918077,
-0.0017975423,
0.0044257296,
0.024426877,
-0.022837816,
0.0077877087,
-0.030047685,
0.024571337,
-0.005180862,
0.02675137,
-0.014354073,
0.006251179,
0.005269508,
-0.03372485,
0.018701008,
-0.006251179,
-0.022890348,
-0.007846806,
-0.021012368,
-0.010749139,
0.035274513,
0.0054960474,
0.02001428,
0.021235624,
0.02834043,
0.020237537,
-0.013244358,
0.011674996,
-0.0033160143,
-0.017295804,
-0.0027233998,
-0.0056076753,
-0.03464414,
-0.00653025,
0.004593172,
0.00993491,
-0.007840239,
-0.0095737595,
0.020710314,
-0.013441348,
0.021288155,
-0.00031354392,
-0.0073543284,
-0.020723447,
-0.036981765,
0.06886803,
0.01640278,
-0.0089959195,
-0.0217478,
0.011051192,
0.005706171,
0.005958976,
0.01327719,
-0.009258574,
0.03713936,
-0.019567767,
0.02053959,
-0.0054632155,
-0.0024870106,
0.0041630752,
-0.005276074,
-0.00572587,
0.017111946,
-0.0159694,
-0.017689787,
-0.009074716,
0.0053811357,
0.025845211,
-0.0022440553,
0.0051086317,
-0.020408262,
0.0156016825,
0.0034670406,
-0.013802499,
0.0082342215,
0.0059359935,
0.005486198,
0.0106703425,
0.024663266,
-0.008871159,
-0.007117939,
-0.006914382,
-0.0035425539,
-0.0010489768,
-0.020684049,
-0.014997577,
0.010854201,
0.00039952225,
-0.014275277,
0.0025707318,
0.019817289,
0.022864083,
-0.00971822,
-0.0087201325,
-0.00529249,
-0.020920439,
-0.009987441,
0.00014415223,
0.037454545,
-0.06287951,
-0.023993498,
-0.015194568,
-0.0031354392,
0.00522026,
-0.013415083,
-0.0015997306,
-0.0012467885,
-0.014130817,
-0.01462986,
-0.00032462465,
-0.16326609,
0.006966913,
0.012200306,
-0.012692783,
0.03007395,
0.0024000064,
-0.023940966,
-0.006044339,
0.014761188,
0.0058276486,
0.03713936,
0.005739003,
-0.033015683,
-0.025582558,
0.00085034425,
0.010210698,
0.02131442,
0.058151726,
0.023586383,
0.017046282,
0.034670405,
-0.020237537,
0.01707255,
-0.007912469,
0.0015677196,
-0.0047409153,
0.00027742892,
-0.009882379,
0.00059302483,
-0.006947214,
-0.013526712,
-0.0025674487,
0.034906793,
0.0036870139,
0.027578732,
-0.011799757,
0.006874984,
-0.012784712,
-0.0017647105,
0.034381486,
0.047986995,
0.022562029,
0.019160653,
0.008615071,
-0.026869565,
0.025858345,
0.016836159,
0.0020749713,
0.03204386,
-0.019502103,
0.0039857836,
-0.032411575,
0.00044117763,
0.019029325,
0.030756852,
0.028997067,
0.0032224434,
0.010381423,
-0.01602193,
-0.00073748484,
-0.007932168,
-0.022588294,
0.030783119,
-0.004681818,
0.005978675,
-0.009547494,
0.0039825,
0.04239245,
-0.011405775,
0.0048459773,
-0.03112457,
-0.014918781,
0.002629829,
-0.009376769,
0.01255489,
-0.007124506,
-0.00032831825,
0.010742573,
0.008076629,
0.012265969,
0.0021307853,
0.02510978,
-0.0039529516,
-0.026974626,
-0.010834502,
-0.007833674,
-0.0022062985,
0.026817033,
-0.023258064,
-0.0056766225,
0.017807981,
-0.032070126,
0.01948897,
-0.019935483,
0.022667091,
0.030940711,
-0.0030779834,
-0.011924518,
-0.01679676,
-0.010460219,
-0.0053318883,
0.004048164,
-0.006894683,
0.019475838,
-0.005154596,
0.011241617,
-0.035379574,
-0.01856968,
0.01462986,
-0.025149178,
0.0073214965,
-0.0012681292,
0.0297325,
0.029338518,
-0.013539844,
0.018477751,
-0.008385248,
-0.0015652572,
-0.0035064388,
-0.029023333,
0.05762642,
0.02198419,
-0.009737919,
0.020999234,
-0.008858026,
-0.03522198,
-0.13531965,
-0.012325067,
-0.0032733327,
0.0049608885,
-0.0070654084,
0.01640278,
0.008391814,
0.015220834,
-0.024046028,
0.024715796,
-0.037664667,
0.0017729185,
0.00203229,
-0.009173212,
-0.0065630814,
-0.01625832,
0.022049854,
-0.014616728,
-0.0156016825,
0.02396723,
-0.0073280632,
-0.01253519,
0.03574729,
-0.0018894714,
0.034512814,
-0.0039726505,
-0.01564108,
0.003381678,
0.005689755,
0.01253519,
0.011031493,
-0.0044716946,
0.008943389,
-0.0004440504,
-0.011845722,
-0.0075907176,
-0.020749712,
-0.02001428,
0.014235878,
0.005837498,
0.012640252,
0.009186344,
-0.012633686,
-0.0019764758,
-0.0015028768,
0.0023819488,
-0.0032011028,
0.015089506,
0.032385312,
-0.011438607,
-0.018530281,
-0.021012368,
-0.04354813,
-0.022929747,
0.014695524,
0.0033439212,
0.004826278,
0.021117428,
-0.026593776,
0.009455565,
-0.008017532,
0.004084279,
-0.014537931,
-0.000056173198,
0.045097794,
-0.01707255,
0.005650357,
-0.022496365,
0.027552467,
-0.0058177994,
0.004087562,
-0.0059261443,
-0.0041203937,
-0.01751906,
-0.001746653,
-0.0100005735,
-0.019160653,
-0.01625832,
-0.008910557,
-0.010059671,
-0.016914956,
-0.018096901,
0.011478006,
-0.011510838,
0.040343747,
0.00015728496,
-0.005761985,
-0.009613158,
-0.0023359843,
-0.004767181,
-0.009777317,
0.027132219,
0.0115962,
-0.0026577362,
-0.011070891,
0.011392643,
-0.020946704,
-0.006208498,
0.029338518,
0.040658932,
-0.010085937,
0.0022818118,
-0.057573885,
0.02458447,
-0.032464106,
0.010690042,
-0.0060410555,
-0.016350249,
0.0078074075,
-0.010210698,
0.023822771,
0.050009433,
-0.039923497,
0.020303199,
0.008037231,
0.020854775,
-0.019449573,
-0.025608823,
0.022890348,
0.0052268263,
0.008851459,
0.018832333,
-0.0012254479,
-0.02718475,
-0.006914382,
0.0042024734,
-0.008989354,
-0.0034473415,
-0.0064514535,
0.032542903,
-0.014327808,
-0.01072944,
-0.0073017976,
-0.02281155,
-0.01818883,
0.006622179,
-0.02507038,
-0.045439243,
-0.019974882,
0.016087594,
0.017821115,
0.031360958,
-0.0021783914,
-0.05836185,
-0.0026938512,
0.003654182,
-0.0004284553,
-0.033829913,
-0.018976795,
0.0075316206,
0.002457462,
-0.02006681,
0.042838965,
0.008772664,
-0.02328433,
-0.022956012,
-0.014761188,
0.030441668,
-0.008175124,
-0.03564223,
-0.0048459773,
-0.03325207,
0.014971311,
0.02583208,
0.0057981,
0.03411883,
-0.0007969925,
-0.019134387,
-0.041945938,
-0.0068158866,
0.0016038346,
0.0025264088,
-0.017361468,
0.019567767,
0.009192911,
-0.008024097,
0.029863827,
0.0016128634,
-0.006050905,
-0.0148399845,
-0.019449573,
0.025569424,
0.002743099,
0.009521229,
-0.0074068597,
0.015260232,
0.024046028,
0.004773747,
-0.03209639,
0.025582558,
-0.0031075322,
-0.0025543158,
-0.0013083481,
0.008056929,
0.009475265,
-0.00023043837,
0.022049854,
0.01217404,
0.012935739,
0.010374856,
0.015115771,
0.014183348,
0.030205278,
-0.0037953588,
-0.006037772,
-0.016849292,
0.007912469,
0.011766925,
-0.025464363,
-0.018609079,
0.007577585,
0.013145862,
0.026186662,
0.001120386,
-0.015430957,
-0.0003701788,
-0.032070126,
0.008411514,
0.0029121828,
0.008319584,
-0.009468698,
0.025227973,
0.021826597,
0.008030664,
0.0032667664,
-0.0034965891,
-0.0036016512,
0.016875558,
0.03007395,
-0.02478146,
0.010716307,
-0.009508097,
0.009061583,
-0.0007777038,
-0.053345148,
-0.0045636236,
-0.009074716,
-0.016823027,
0.0123382,
0.038216244,
0.0023064357,
0.09103608,
0.009691955,
-0.0059655425,
0.008943389,
-0.021419482,
0.011990182,
0.016717965,
0.012397297,
-0.0036837307,
-0.042655107,
0.024925921,
0.006874984,
0.020815376,
-0.034040034,
-0.012167474,
-0.00047277825,
-0.02073658,
0.0112481825,
-0.0017565025,
-0.025241107,
0.016284585,
-0.014117684,
-0.01779485,
0.014472268,
-0.023927834,
0.006697692,
0.0341451,
-0.005164446,
0.009560627,
-0.027893918,
0.009711654,
0.011425475,
-0.037454545,
-0.016678566,
0.0050134193,
-0.0041860575,
-0.0023540417,
-0.016731098,
-0.00062011107,
0.020224404,
-0.024256151,
0.024361214,
-0.021760933,
-0.037218157,
0.030389136,
-0.00203229,
-0.020316333,
0.0063792234,
-0.01679676
] |
Natural killer (NK) cells are potent cytotoxic effector cells for cancer therapy and potentially for severe viral infections. However, there are technical challenges to obtain sufficient numbers of functionally active NK cells from a patient's blood since they represent only 10% of the lymphocytes and are often dysfunctional. The alternative is to obtain cells from a healthy donor, which requires depletion of the allogeneic T cells to prevent graft-versus-host reactions. Cytotoxic cell lines have been established from patients with clonal NK-cell lymphoma. Those cells can be expanded in culture in the presence of IL-2. Except for the NK-
|
[
-0.015969502,
0.001381276,
0.008951396,
-0.017095048,
-0.010957515,
0.01696263,
-0.01696263,
0.00069270696,
-0.031382855,
-0.0052006817,
-0.0058495253,
0.012718663,
-0.0037838188,
-0.00495571,
-0.019571248,
0.017518783,
0.028284293,
-0.02354376,
-0.010136529,
-0.020445202,
-0.045180716,
0.01447319,
0.006299744,
-0.019346138,
-0.014685057,
0.023120027,
-0.0051377835,
-0.03885118,
0.008918292,
-0.00897788,
0.006385815,
-0.008084064,
0.0028900034,
-0.0049590203,
0.00611436,
-0.004217485,
0.017929276,
-0.015982745,
0.03392526,
0.023689419,
0.01811466,
0.024589855,
-0.010725785,
-0.0060183574,
0.009130159,
-0.0015625218,
-0.011798364,
-0.009189747,
0.004217485,
0.011487184,
0.026721772,
-0.006696995,
-0.011387871,
0.016154887,
-0.03800371,
-0.025622709,
-0.009229472,
-0.005558208,
0.008805738,
-0.03180659,
-0.017863067,
-0.00008213999,
-0.009845212,
0.019346138,
0.014075938,
0.021398604,
-0.009097055,
0.012520038,
-0.0064917486,
0.0016634898,
0.0037738874,
0.031329885,
-0.011487184,
0.027224956,
0.0061904998,
-0.010407984,
-0.000008605819,
0.0020508098,
-0.0073292865,
-0.006852585,
0.02623183,
-0.03159472,
-0.018882679,
0.023159752,
0.02020685,
0.01215589,
0.0065844404,
0.008090685,
0.013797862,
-0.004164518,
0.0032789786,
0.023623211,
0.016909664,
0.013367507,
-0.01130842,
0.032548126,
0.018154385,
0.0045121126,
0.0033716706,
-0.03779184,
0.00874615,
0.0061342223,
-0.021041078,
-0.014446706,
-0.04878246,
-0.0009459547,
0.01114952,
-0.021067562,
0.037579972,
0.010242463,
-0.027198473,
0.01896213,
0.002082259,
-0.03477273,
0.064672515,
0.005852836,
0.019491797,
-0.014764507,
-0.033263177,
0.0005238752,
0.022378491,
0.0052470276,
0.024219088,
-0.017982243,
0.019915532,
0.0018852885,
0.005114611,
-0.025503535,
-0.036414705,
-0.0107390275,
0.021478055,
0.012784871,
0.006296433,
0.017293673,
0.0132019855,
0.007415358,
-0.006455334,
-0.011036966,
0.0061077387,
-0.0066009928,
0.014314289,
0.03204494,
0.024642823,
0.008997742,
-0.0041413447,
0.016300546,
0.027119024,
-0.006130912,
-0.0048663286,
-0.00071546616,
-0.010196117,
-0.008626974,
0.03143582,
-0.030959118,
-0.00433335,
-0.0030489038,
0.0016783868,
0.02741034,
-0.015029341,
-0.009342027,
-0.020114157,
-0.025066558,
0.019226963,
-0.020392234,
0.01680373,
0.028522644,
0.006591061,
0.01966394,
-0.0012645833,
-0.0006136705,
0.010209358,
0.03599097,
-0.001273687,
0.020193608,
-0.017148014,
0.010235842,
0.004449215,
0.0052073025,
-0.01998174,
-0.008838842,
0.00037614733,
0.03895711,
0.007786126,
-0.008805738,
-0.009004363,
-0.009593619,
0.020974869,
-0.03726217,
-0.0051311627,
-0.006640718,
-0.0029793847,
-0.003422982,
-0.0020425338,
-0.034428447,
-0.63390714,
-0.025225459,
0.0144202225,
0.008322415,
0.001545142,
0.015744394,
0.023504036,
-0.0253976,
-0.025688918,
0.0069320356,
-0.00197467,
-0.0050219186,
0.007216732,
-0.019346138,
-0.024642823,
-0.042029187,
-0.01686994,
-0.00054787577,
0.024907658,
-0.015611976,
-0.005088127,
-0.02229904,
-0.020657068,
0.008991121,
-0.017518783,
0.009534031,
0.010599989,
0.009639965,
0.006898931,
0.051377837,
-0.008256206,
0.03011165,
-0.008189998,
-0.0023636452,
0.051536735,
0.0044061793,
-0.0047471533,
0.017783618,
0.009063951,
0.020551134,
-0.00518413,
0.0012769975,
0.01680373,
0.0015087273,
-0.013195365,
-0.00038752693,
-0.005700556,
-0.0065976824,
0.0008640216,
0.01355289,
0.025794853,
0.012824597,
-0.032812957,
0.011652705,
0.0041214824,
0.00789868,
0.0037507145,
-0.015227967,
0.009904799,
-0.007216732,
-0.0013390679,
0.009044088,
-0.018021967,
-0.02717199,
-0.015969502,
0.009918041,
-0.01696263,
0.01686994,
0.0020789485,
-0.0010287154,
0.028708028,
0.018591361,
-0.008170135,
0.0023934392,
0.011864573,
0.017161256,
0.015837086,
-0.036679536,
-0.005174198,
-0.008355519,
-0.013771378,
-0.020604102,
-0.021557504,
0.018604603,
0.008799116,
-0.0004659427,
-0.019875808,
0.017148014,
0.026509903,
0.012950392,
0.0062931227,
0.007223353,
0.006620855,
-0.04862356,
-0.024576614,
0.02121322,
-0.014989616,
-0.01595626,
-0.0015832119,
-0.03630877,
-0.016684555,
-0.022775741,
0.024470681,
-0.0063129854,
0.0055217934,
-0.003515674,
-0.047484774,
-0.0021319154,
0.045472033,
-0.040996335,
0.0031697345,
-0.01541335,
0.014195113,
0.00557476,
0.025503535,
-0.011116416,
0.012215477,
0.02151778,
-0.004498871,
-0.04576335,
0.014459948,
0.005319857,
0.008481315,
-0.013301298,
0.019942015,
-0.0072498363,
-0.014923408,
-0.021305911,
-0.0012174097,
-0.02748979,
-0.008408486,
-0.014645332,
0.009189747,
-0.011500426,
0.026403971,
0.00015869363,
0.014645332,
-0.003886442,
0.0011139589,
-0.02082921,
-0.021478055,
-0.012314791,
-0.0029860057,
0.004482319,
0.016737523,
0.011209108,
-0.0033385663,
-0.01222872,
-0.0115600135,
-0.0010171289,
0.017611476,
-0.0040685157,
-0.00095009274,
0.014327531,
0.02314651,
-0.016406478,
-0.009275818,
-0.02137212,
0.02608617,
-0.017253948,
-0.011725535,
0.008633595,
0.012374379,
0.010182875,
0.00960024,
0.0040685157,
-0.008322415,
0.013301298,
0.012758388,
-0.055138484,
-0.0057469024,
-0.010494055,
-0.02261684,
0.0057469024,
-0.003422982,
-0.029158246,
-0.006759893,
-0.00944796,
0.008871946,
0.01463209,
0.008408486,
-0.034190096,
0.002299092,
0.00058139383,
0.016379995,
0.0075676376,
0.030164616,
0.0047107385,
-0.019491797,
0.02282871,
-0.017452573,
0.0031101466,
-0.01958449,
0.007719917,
0.021186737,
-0.024126396,
-0.0032839442,
0.023027334,
0.008137031,
0.028443193,
0.00053256506,
-0.007733159,
0.021332396,
-0.022007722,
0.01988905,
-0.006885689,
-0.0021170184,
-0.024894416,
0.01067944,
0.009573757,
0.012288307,
0.006640718,
-0.008415107,
0.01347344,
0.018088177,
0.010023975,
-0.0027377235,
0.00018176317,
0.0035620201,
-0.03445493,
-0.0006339469,
-0.013427095,
0.02338486,
-0.019928774,
-0.004949089,
0.007905301,
0.015784118,
0.020498168,
0.0077927466,
-0.008507799,
-0.011189246,
-0.01541335,
0.007170386,
-0.0027956562,
0.024987107,
0.008342277,
0.020908661,
-0.011328283,
0.018710537,
0.0033104275,
-0.019107789,
0.001911772,
-0.004793499,
0.0017876308,
0.0056972457,
-0.014685057,
0.017916035,
0.011977127,
-0.022749258,
0.010613231,
-0.005319857,
0.016790489,
-0.035805583,
0.013228469,
-0.000983197,
-0.030482417,
-0.0012943771,
-0.0019217032,
0.041764356,
0.025794853,
0.016128404,
-0.030853186,
0.017412849,
-0.018260319,
-0.0020938455,
-0.0047339112,
0.013380748,
-0.012016852,
0.0012215478,
0.0142215965,
-0.023715904,
-0.006286502,
0.021094045,
-0.020537892,
0.012142648,
0.026827706,
0.0142215965,
0.00991142,
0.018498668,
0.0019961877,
-0.02407343,
-0.017505541,
0.025146008,
0.024470681,
-0.002532477,
-0.012983497,
-0.035090532,
-0.01316226,
-0.00036807818,
0.009918041,
0.01811466,
0.0017776996,
-0.005935597,
-0.0015575562,
-0.012751767,
-0.007746401,
0.018789986,
-0.0019001855,
0.013281436,
-0.005055023,
0.01696263,
-0.025768368,
-0.03336911,
0.00086733204,
0.013533028,
0.01044771,
-0.00133493,
-0.017042082,
0.0040916884,
-0.006591061,
-0.00030580076,
-0.002903245,
0.004627978,
-0.026960121,
-0.00704459,
0.0013721723,
0.01355289,
0.033422075,
-0.004042032,
0.0019250136,
-0.007137282,
-0.031541754,
-0.008613733,
-0.013182122,
0.035726134,
-0.0027459997,
-0.0021501228,
0.018445702,
-0.0024480612,
0.0022130208,
0.00541917,
-0.012612729,
0.03800371,
-0.018604603,
0.00766695,
0.0026979984,
0.0037672666,
-0.0029131763,
0.0023321963,
0.02934363,
-0.008626974,
0.003050559,
-0.018789986,
-0.0034560864,
0.0071836277,
-0.006299744,
0.040387217,
0.024828207,
0.018525153,
0.010858202,
0.02608617,
0.020723276,
0.006710237,
0.0020640516,
-0.0065546464,
0.026377488,
-0.0015881776,
0.0014541054,
-0.017214224,
-0.017320158,
0.009242713,
0.022285799,
0.0068724477,
-0.007726538,
0.032548126,
0.005147715,
-0.007627225,
-0.009342027,
0.015890053,
-0.007236595,
0.012334653,
0.0071107983,
0.002237849,
-0.020577617,
0.02485469,
-0.022736017,
-0.030561868,
-0.008262827,
-0.009739278,
0.035434816,
-0.008766012,
0.010017354,
0.011626221,
0.0043697646,
-0.0043234183,
-0.02873451,
0.017002355,
0.015280934,
-0.016975872,
-0.014301047,
-0.00952741,
0.0008648492,
-0.03275999,
-0.03035,
0.029926265,
-0.00129686,
-0.006220293,
0.010666198,
0.012672317,
-0.008633595,
0.004783568,
-0.021703163,
0.006356021,
0.02894638,
-0.009686311,
-0.0048497766,
-0.01905482,
-0.04126117,
0.0015658323,
-0.000789537,
-0.0074352203,
-0.007600742,
-0.007647088,
-0.013771378,
-0.002423233,
-0.0070776944,
-0.012016852,
-0.0009310578,
-0.019134272,
0.0178101,
0.019756632,
0.0028337261,
-0.0070114858,
-0.009163263,
-0.023636453,
-0.010341776,
-0.0065976824,
-0.028310778,
-0.027887043,
-0.024894416,
-3.2328394e-8,
0.028549127,
-0.002909866,
-0.019783115,
0.04258534,
-0.015810601,
0.01347344,
-0.017664442,
-0.000025423049,
0.027463308,
0.0140229715,
0.012970256,
0.015016099,
-0.011076691,
-0.019306414,
-0.021848822,
0.020577617,
-0.006044841,
-0.0028370365,
-0.011083311,
0.012645833,
-0.020935144,
0.00301911,
-0.0047339112,
-0.021425087,
-0.008123789,
-0.010580126,
-0.009918041,
-0.03204494,
-0.021703163,
0.012003611,
0.02616562,
0.03172714,
-0.026099412,
-0.007633846,
0.02082921,
0.016697796,
-0.002073983,
0.003740783,
-0.031144504,
-0.019001855,
0.031939004,
-0.007640467,
-0.007971509,
-0.024285296,
0.0054853787,
-0.023358377,
-0.027701657,
-0.016406478,
-0.025463808,
-0.008924913,
0.018167626,
0.040148865,
0.038215578,
0.020233333,
-0.008137031,
0.02817836,
-0.00080815813,
-0.011036966,
0.010454331,
-0.0050914376,
0.031065052,
-0.02873451,
0.008891809,
0.0029380044,
-0.01942559,
-0.002757586,
-0.013811104,
0.0086468365,
0.028866928,
-0.01408918,
-0.04086392,
0.0015716255,
-0.014539398,
-0.01579736,
0.01696263,
-0.015890053,
0.029078797,
-0.004770326,
0.006170637,
0.013784621,
-0.00658113,
-0.0024265435,
0.012599488,
0.011652705,
0.0007928474,
-0.014910166,
-0.0112223495,
0.012294928,
-0.027595725,
-0.0032558055,
-0.0026417212,
0.0063460898,
-0.009454581,
0.022259315,
0.0016783868,
0.025530018,
-0.02423233,
-0.0029462806,
-0.0024364747,
-0.031859554,
-0.033951744,
-0.008739529,
-0.02725144,
-0.022020964,
0.013850829,
-0.022881676,
-0.0014474845,
-0.010249084,
0.0148174735,
-0.009428098,
0.0034560864,
0.0032475295,
-0.037844807,
0.021067562,
-0.027145507,
0.013585995,
-0.029873298,
0.017704166,
0.0064685754,
0.0034428446,
-0.016777247,
-0.011831468,
-0.00596208,
0.003677885,
0.023040576,
0.021107286,
-0.0041910014,
-0.0020458442,
0.00889843,
0.014486431,
-0.008991121,
-0.023133269,
0.02214014,
-0.021319153,
0.026999848,
-0.025609467,
-0.018869437,
-0.03265406,
0.016989114,
0.024139637,
0.015611976,
0.0034362238,
-0.0017512162,
-0.0308267,
0.02469579,
-0.0057965587,
0.0029942817,
-0.005604554,
-0.015386867,
-0.016525654,
-0.03903656,
-0.018141143,
-0.012970256,
-0.01316226,
0.015122034,
0.00425721,
-0.01400973,
0.0452072,
-0.015453076,
0.016234336,
0.0057733855,
-0.020908661,
0.046955105,
-0.0075676376,
0.0070578316,
0.02314651,
-0.00055656565,
0.012824597,
-0.01300336,
-0.010983999,
0.0135131655,
-0.03305131,
-0.011520288,
0.04134062,
0.022338765,
-0.013559512,
0.016631588,
-0.028443193,
-0.02089542,
-0.04322094,
-0.03336911,
0.0051609566,
-0.025874302,
0.011871194,
0.004909364,
-0.000105312974,
-0.00027373098,
-0.008626974,
0.0057733855,
0.01037488,
0.041314136,
-0.008421727,
0.005995184,
0.008686562,
0.018789986,
-0.022444699,
-0.0017909413,
0.00076015695,
-0.022007722,
0.0067929975,
-0.007719917,
-0.040148865,
-0.021623714,
-0.01664483,
0.017677683,
0.026059685,
-0.0078258505,
0.015360384,
0.029529015,
0.01788955,
-0.0014243114,
-0.018472185,
0.028443193,
-0.015850328,
-0.013142398,
0.011242212,
-0.029608464,
-0.023662936,
-0.0038732004,
-0.0070644524,
-0.0053860657,
0.00035483646,
-0.035037566,
-0.025344634,
0.0028618646,
0.006054772,
0.011566634,
-0.014658573,
0.009964387,
-0.024444198,
0.0034362238,
0.031303402,
-0.011996989,
-0.009010984,
0.011156141,
0.0024265435,
0.033633944,
-0.015386867,
-0.0032061492,
-0.0058329734,
-0.050662782,
-0.018829713,
-0.00048870186,
-0.016353512,
0.030482417,
0.00813041,
0.015135275,
-0.030482417,
0.006571199,
-0.047405325,
0.001509555,
0.0012339619,
0.026284795,
0.011109795,
0.044624563,
-0.015400109,
-0.0029297285,
-0.011401112,
0.024497164,
-0.011361388,
-0.020789485,
0.044492148,
-0.0007196042,
0.031144504,
-0.0013696894,
-0.02346431,
0.0016734211,
0.018723778,
-0.0028453125,
-0.008640216,
0.02261684,
-0.009150022,
0.0051444042,
-0.0039857547,
0.015784118,
0.005690625,
0.01988905,
-0.0029942817,
-0.01463209,
-0.010096804,
0.009110297,
0.0056177955,
-0.000250558,
0.0042538997,
0.0047206697,
0.004978883,
0.0035421576,
-0.0069386563,
-0.047882024,
0.0039658924,
-0.022020964,
0.016525654,
0.018339768,
-0.0131755015,
0.023702662,
-0.004313487,
-0.000023496277,
0.007322666,
-0.008805738,
-0.0017230776,
-0.0036811954,
0.0036348496,
0.01114952,
-0.003111802,
0.013877313,
0.009653207,
-0.0227625,
0.0017561818,
0.02051141,
-0.00120003,
-0.032071423,
0.010110046,
0.019690424,
-0.01036826,
0.01880323,
0.024828207,
-0.006865827,
-0.013943521,
-0.010116667,
0.012473691,
-0.0063063647,
0.0057800068,
-0.005528414,
0.002919797,
-0.041234687,
-0.00027352409,
-0.02074976,
-0.013652204,
0.00064843,
0.18644328,
-0.030535383,
-0.0012993428,
0.018617844,
-0.009560515,
-0.005750213,
-0.010778752,
-0.0053562718,
0.0046345987,
-0.00920961,
0.03599097,
-0.013043085,
-0.016777247,
-0.0047471533,
0.016366754,
-0.012321412,
-0.02004795,
-0.01408918,
-0.019107789,
0.00027228266,
-0.0041711386,
0.008189998,
0.020273058,
0.010646335,
0.029555498,
0.001865426,
-0.017624717,
0.010593369,
0.02384832,
-0.014910166,
-0.02741034,
0.013970004,
0.011599738,
-0.003227667,
0.018670812,
0.004353212,
0.00043573504,
-0.010441089,
0.010341776,
-0.009275818,
0.0066936845,
0.015559009,
-0.019094547,
0.020273058,
0.00921623,
0.03715624,
-0.0057866275,
-0.0008557455,
-0.0031912522,
-0.008223102,
-0.039592713,
-0.020114157,
0.0054158596,
0.00094347185,
0.00067656866,
0.002307368,
0.025093041,
0.00913678,
-0.0049259164,
0.035196465,
-0.018498668,
0.010355017,
-0.021928273,
0.04226754,
0.0025440636,
0.016909664,
-0.0064122984,
-0.02314651,
0.020484926,
-0.0052569592,
-0.011262075,
-0.0011123037,
-0.0128643215,
0.0020491546,
-0.009951145,
-0.017121531,
0.008415107,
0.03011165,
0.014036213,
-0.0009691277,
0.019213721,
0.0017760444,
-0.014671815,
0.023504036,
0.0041843806,
-0.02345107,
0.0054853787,
0.018405978,
-0.024179364,
-0.008719666,
0.0040751365,
-0.005124542,
-0.016764006,
0.00626995,
0.010116667,
0.00983197,
0.013109293,
0.0027675175,
-0.0037771978,
-0.04303556,
-0.021862064,
0.083263874,
-0.0043399706,
0.014936649,
-0.016671313,
0.0073028035,
-0.008991121,
-0.002423233,
-0.008507799,
-0.014314289,
0.02151778,
-0.021491297,
0.021464812,
-0.004373075,
-0.010282188,
0.027648691,
-0.012950392,
-0.028443193,
0.02601996,
-0.005164267,
-0.0018157696,
-0.017783618,
0.006435471,
0.018776745,
-0.004234037,
0.018392736,
-0.037421074,
0.009004363,
0.004998746,
-0.035858553,
-0.011202487,
-0.010884686,
-0.0055482765,
0.033766363,
0.012824597,
-0.014830716,
0.0071637654,
-0.018458944,
-0.0047173593,
-0.014923408,
-0.0047471533,
-0.015810601,
-0.0038202335,
0.011884435,
0.01586357,
0.0072829407,
0.031356372,
0.018021967,
-0.005409239,
-0.016591864,
-0.010050458,
-0.03800371,
-0.016671313,
-0.0037374727,
0.027648691,
-0.006064703,
-0.019213721,
0.0069717607,
0.0057667647,
0.0065314737,
-0.014870441,
0.013466819,
0.015280934,
-0.02245794,
-0.015439834,
-0.03268054,
-0.16546841,
0.011493805,
-0.0010816822,
-0.0152412085,
0.03800371,
0.008871946,
-0.020246575,
-0.0046643927,
-0.006279881,
0.024351506,
0.037368108,
-0.0057104877,
-0.036785472,
-0.018948888,
0.013797862,
-0.012923909,
0.0039824443,
0.032918893,
0.029979233,
0.008395244,
0.026933638,
0.0057932483,
0.0050020562,
-0.00033083584,
-0.0044260416,
-0.0043631434,
-0.0041314135,
-0.018525153,
0.00039911343,
-0.013691928,
-0.000673672,
0.005674073,
0.0023636452,
-0.017823342,
0.005859457,
0.005915734,
0.005458895,
-0.014499673,
0.006415609,
0.016671313,
0.032389224,
0.010222601,
0.00960024,
0.0011363042,
-0.017306915,
0.038268544,
-0.00181908,
-0.024430955,
0.004932537,
-0.013665445,
0.02725144,
-0.010573505,
0.014830716,
0.017863067,
0.0057270397,
0.01416863,
0.018842954,
-0.006154085,
0.012341274,
0.023172993,
-0.0029595222,
-0.019226963,
-0.0115335295,
-0.008163515,
-0.007971509,
-0.02439123,
-0.015082308,
0.022020964,
-0.008468074,
-0.001896875,
-0.032601092,
-0.00071587996,
0.04094337,
-0.017942518,
0.032071423,
-0.005018608,
-0.006495059,
0.00040097555,
0.008329036,
0.010474193,
-0.018922403,
0.013943521,
-0.0032789786,
-0.016234336,
-0.016432963,
0.0086468365,
0.013943521,
0.003939409,
-0.012970256,
-0.011341525,
-0.0077596423,
-0.026509903,
0.000524289,
-0.015585493,
0.019372622,
0.03453438,
0.017995484,
-0.020802727,
-0.005604554,
-0.000106450934,
0.023093542,
-0.01230817,
-0.013519786,
0.0017992174,
0.030879669,
-0.006991623,
-0.01865757,
-0.0045485273,
0.016207853,
0.007501429,
-0.023782112,
0.0041777594,
0.0132880565,
0.014896925,
-0.0046180463,
0.017042082,
-0.0064586443,
-0.013903796,
0.014075938,
-0.036414705,
0.06785052,
0.0014491397,
-0.018948888,
0.015770877,
-0.0021534332,
-0.027940009,
-0.12976876,
-0.007627225,
0.03223032,
0.0027261372,
-0.011705672,
0.024510406,
0.0046114256,
0.010388122,
-0.018127901,
0.017200982,
-0.017240707,
-0.0003715955,
-0.0019233584,
0.0041777594,
0.02748979,
0.015280934,
-0.0056939353,
-0.012109544,
-0.018061694,
0.02639073,
0.02236525,
0.0050285393,
-0.011685809,
-0.011838089,
-0.0017743892,
0.00580649,
-0.029449563,
0.03223032,
0.016591864,
0.025755126,
0.0305089,
-0.00020907419,
0.018723778,
-0.021080803,
-0.029661432,
0.01904158,
-0.037447557,
-0.020299543,
0.013341024,
-0.04367116,
-0.0226036,
0.01370517,
-0.002817174,
-0.006534784,
0.01416863,
-0.027675174,
-0.025146008,
0.025225459,
0.030588351,
0.0019068063,
-0.015691428,
-0.03599097,
-0.058793195,
-0.021186737,
0.03622932,
-0.032601092,
0.020299543,
0.0070181065,
-0.033395592,
-0.016565379,
0.00043739023,
0.0074484623,
0.013374127,
-0.0029049001,
0.035805583,
-0.00054166873,
-0.025331391,
-0.011752018,
0.015810601,
-0.0308267,
0.002166675,
-0.016975872,
-0.020617343,
-0.016618347,
-0.0039923755,
0.019068062,
0.0052834423,
0.012738525,
0.0019084614,
-0.010553643,
-0.021027837,
-0.016975872,
0.014049455,
0.0075279125,
0.036335252,
-0.008342277,
0.0014764507,
-0.005425791,
0.00022304006,
-0.014618848,
-0.021027837,
0.035938002,
-0.017836584,
0.0032144252,
0.0009145056,
0.0059521487,
0.0013142398,
0.0022080552,
0.025437325,
0.04173787,
-0.009659828,
-0.022974368,
-0.05164267,
0.0064520235,
-0.012188994,
0.009686311,
-0.0086667,
-0.017902792,
0.005564829,
-0.016154887,
0.030005716,
0.040042933,
-0.027860558,
0.0042538997,
-0.027092539,
0.02198124,
-0.035752617,
-0.029714398,
0.006776445,
-0.01696263,
0.0006293951,
0.021901788,
0.0018339768,
-0.011401112,
0.0023603349,
-0.0038798212,
0.015598735,
-0.0064586443,
0.0013862415,
0.030800218,
0.009699553,
-0.0024513716,
0.025808094,
-0.031674173,
-0.011420975,
0.007130661,
-0.010361638,
-0.015784118,
0.0018422529,
0.017280431,
-0.0011354766,
0.029687915,
-0.027754625,
-0.02694688,
0.009971008,
0.0069651394,
-0.02221959,
-0.004008928,
-0.012281686,
0.022537392,
-0.0058263526,
-0.008818979,
0.056992322,
0.00928906,
-0.0014226562,
-0.033104274,
-0.005290063,
0.014592364,
0.018220594,
-0.015082308,
-0.009116918,
-0.0007506395,
0.007037969,
0.022034205,
0.029449563,
0.016419722,
-0.031118019,
-0.02910528,
-0.024007222,
0.006216983,
0.017717408,
0.004929227,
-0.0016601795,
0.031065052,
-0.011215729,
-0.0056641414,
0.016711038,
-0.004829914,
-0.006852585,
0.002416612,
-0.010037216,
0.011480563,
0.014685057,
-0.0021782613,
-0.017055323,
0.0027675175,
0.03400471,
-0.0033865673,
0.0045617693,
0.034110647,
0.021729646,
0.009686311,
-0.009659828,
0.008785875,
0.013744895,
0.020392234,
0.014446706,
0.026589355,
-0.013480061,
0.016671313,
0.0015848672,
0.030217582,
-0.0014640366,
-0.004469077,
0.02648342,
-0.022749258,
-0.0008722977,
0.012341274,
-0.027145507,
-0.022563875,
-0.030985603,
-0.012546521,
0.023199476,
-0.0005967046,
0.0048663286,
0.006415609,
-0.049921248,
0.0049755727,
0.013374127,
-0.008097306,
-0.024841448,
0.028151875,
0.009308922,
0.023212718,
0.018313285,
0.000015866775,
0.006898931,
0.009461202,
0.025424084,
-0.011910918,
0.01618137,
-0.012652454,
0.0071637654,
-0.010844961,
-0.0461606,
-0.005309926,
0.002995937,
-0.022497665,
0.02616562,
0.0061507747,
0.003863269,
0.05487365,
-0.0006289812,
-0.016221095,
0.006180568,
-0.032256808,
0.0126656955,
0.012553141,
-0.008216482,
-0.0067731347,
-0.01912103,
0.028893411,
-0.010275567,
0.03328966,
-0.029025828,
-0.042135123,
0.020127399,
0.009845212,
0.0035520887,
0.021266187,
-0.0020524652,
0.008143652,
-0.012248582,
-0.0038897523,
0.010520539,
-0.00913678,
-0.009904799,
0.014446706,
-0.009865074,
0.012983497,
-0.035567235,
0.017095048,
-0.00037366452,
-0.036732506,
-0.01634027,
0.011626221,
-0.020789485,
-0.011454079,
-0.026258312,
-0.005164267,
0.036706023,
0.0021401914,
0.032336257,
-0.012215477,
-0.016062194,
-0.018842954,
-0.017280431,
-0.03373988,
-0.011036966,
-0.0032690472
] |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.