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UIDES WITH A CURVILINEAR 2 D FREQUENCY-DOMAIN FINITE-DIFFERENCE APPROACH | Full-wave analysis of guided wave structures using a novel 2-D FDTD | SNARE Function Is Not Involved in Early Endosome Docking | yue_Hant | 19,200 |
Nonlinear age-dependent population dynamics in continuously propagated bacterial cultures | Structured Models of Cell Migration Incorporating Molecular Binding Processes | Methodological constraints in the molecular biodiversity study of a thermomineral spring cyanobacterial mat: a case study | eng_Latn | 19,201 |
MATHEMATICAL-MODELS FOR DOWEL ACTION UNDER MONOTONIC AND CYCLIC CONDITIONS | PREDICTION OF PUNCHING SHEAR CAPACITY OF RC FLAT SLABS USING ARTIFICIAL NEURAL NETWORK | SNARE Function Is Not Involved in Early Endosome Docking | yue_Hant | 19,202 |
Three-helix-bundle Protein in a Ramachandran Model | Coupled Folding-Binding in a Hydrophobic/Polar Protein Model: Impact of Synergistic Folding and Disordered Flanks | The Double Bind as a Universal Pathogenic Situation | eng_Latn | 19,203 |
From single to multiple microcoil flow probe NMR and related capillary techniques: a review | Identification and structure elucidation by NMR spectroscopy | Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling | eng_Latn | 19,204 |
Embedded Multireference Coupled Cluster Theory | OpenMolcas : From Source Code to Insight | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,205 |
The force network ensemble for granular packings | Approximate Stability Analysis for Drystacked Structures | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,206 |
How cooperative are protein folding and unfolding transitions? | Limited cooperativity in protein folding | Limited cooperativity in protein folding | eng_Latn | 19,207 |
Extraction and tracking of the eyelids | Detection of Non-iris Region in the Iris Recognition | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,208 |
arXiv : A Standard Model explanation for the excess of electron-like events in MiniBooNE | New limits on neutrino non-standard mixings based on prescribed singular values | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,209 |
Topology of laminar flow on a spheroid at incidence | Instabilities in the wake of an inclined prolate spheroid | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,210 |
Integrating time of use in large scale traffic simulations | DynaMIT: a simulation-based system for traffic prediction | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,211 |
Protein dynamics by solid state nuclear magnetic resonance. | The Application of REDOR NMR to Understand the Conformation of Epothilone B | Arginine methylation of the HIV-1 nucleocapsid protein results in its diminished function. | eng_Latn | 19,212 |
Noisy colored point set matching | Hierarchical Techniques to Improve Hybrid Point Cloud Registration | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,213 |
Phase unwrapping with differential phase image | Correction for geometric distortion in echo planar images from B0 field variations. | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,214 |
The scanning acoustic microprobe: I. Analysis and synthesis of a spherically symmetric point spread function. | Scatterer size estimation in pulse-echo ultrasound using focused sources: Theoretical approximations and simulation analysis | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,215 |
Shape Parameters and Uniaxial Deformability of Mesogenic Dimers with Flexible Spacers | Atomistic simulations of nematic phases formed by cyano-biphenyl dimers | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,216 |
Stochastic processes in nano-biomachines revealed by single molecule detection. | Rotations of a few cross-bridges in muscle by confocal total internal reflection microscopy. | Inability of the Submaximal Treadmill Stress Test to Predict the Location of Coronary Disease | eng_Latn | 19,217 |
Eignets for function approximation on manifolds | Polynomial approximation on the sphere using scattered data | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,218 |
Cloning, purification, crystallization and preliminary X-ray analysis of the receiver domain of the histidine kinase CKI1 from Arabidopsis thaliana. | Conformational dynamics are a key factor in signaling mediated by the receiver domain of a sensor histidine kinase from Arabidopsis thaliana | Conformational dynamics are a key factor in signaling mediated by the receiver domain of a sensor histidine kinase from Arabidopsis thaliana | eng_Latn | 19,219 |
In silico Homology Modeling and Docking Studies of RecA from Campylobacter jejuni | A superfamily of ATPases with diverse functions containing either classical or deviant ATP-binding motif. | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,220 |
PREFORMED ELASTOMERIC JOINT SEALERS FOR BRIDGES | FIELD STUDY OF LONGITUDINAL MOVEMENTS IN COMPOSITE BRIDGES | SNARE Function Is Not Involved in Early Endosome Docking | kor_Hang | 19,221 |
A Review on Emboss and Deboss Features of Edge Matching | Structured Forests for Fast Edge Detection | SNARE Function Is Not Involved in Early Endosome Docking | kor_Hang | 19,222 |
Tsallis and Kaniadakis Entropic Measures in Stellar Polytropes | On The Generalized Additivity Of Kaniadakis Entropy | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,223 |
Topological Properties of SnSe/EuS and SnTe/CaTe Interfaces | Structural and proximity-induced ferromagnetic properties of topological insulator-magnetic insulator heterostructures | SNARE Function Is Not Involved in Early Endosome Docking | kor_Hang | 19,224 |
Hubs and Non-hubs in Protein-Protein Interaction Networks: A Biophysical Interpretation | Hubs with Network Motifs Organize Modularity Dynamically in the Protein-Protein Interaction Network of Yeast | On the Hypothesis of No "Interaction" In a Multi-way Contingency Table | eng_Latn | 19,225 |
ENTANGLING TWO MULTIATOM CLUSTERS VIA A SINGLE-MODE THERMAL FIELD | Control of two-atom entanglement with two thermal fields in coupled cavities | SNARE Function Is Not Involved in Early Endosome Docking | yue_Hant | 19,226 |
An elastic strip with multiple cracks and applications to tapered specimens | Stressed State of a Plane Wedge-Shaped Specimen with Edge Crack Under Uniaxial Tension | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,227 |
Nearest Window Cluster Queries. | Distance browsing in spatial databases | SNARE Function Is Not Involved in Early Endosome Docking | kor_Hang | 19,228 |
Structural analysis and design of a truss connecting structure for the Space Liner booster | SpaceLiner Technical Progress and Mission Definition | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,229 |
Site-Specific Colloidal Crystal Nucleation by Template-enhanced Particle Transport | Self-organized epitaxial growth on spontaneously nano-patterned templates | Completely Stale Transmitter Channel State Information is Still Very Useful | yue_Hant | 19,230 |
Searching strategy of slime mold and its mathematical model | A coupled-oscillator model with a conservation law for the rhythmic amoeboid movements of plasmodial slime molds | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,231 |
Postsynaptic Stability and Variability Described by a Stochastic Model of Endosomal Trafficking | Plasticity of Dendritic Spines: Subcompartmentalization of Signaling | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,232 |
Stochastic entropy production in the quiet Sun magnetic fields | Nonequilibrium statistical physics of small systems : fluctuation relations and beyond | HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochore | eng_Latn | 19,233 |
DYNAMIC DEFORMATIONS AND STRESSES OF BEAMS CONNECTED BY DAMPING ELEMENT | Vibration problems in engineering | SNARE Function Is Not Involved in Early Endosome Docking | yue_Hant | 19,234 |
Architecture for explicit representation of cause and function in discrete event simulation modeling | Vhdl: Hardware Description and Design | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,235 |
Microstructure of two‐phase random media. IV. Expected surface area of a dispersion of penetrable spheres and its characteristic function | Two-point probability distribution function analysis of Co-polymer nano-composites | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,236 |
Optics clustered to output unique solutions (OCTOPUS) is a microscopy platform that combines single molecule and ensemble imaging methodologies. A novel aspect of OCTOPUS is its laser excitation system, which consists of a central core of interlocked continuous wave and pulsed laser sources, launched into optical fibres and linked via laser combiners. Fibres are plugged into wall-mounted patch panels that reach microscopy end-stations in adjacent rooms. This allows multiple tailor-made combinations of laser colours and time characteristics to be shared by different end-stations minimising the need for laser duplications. This setup brings significant benefits in terms of cost effectiveness, ease of operation, and user safety. The modular nature of OCTOPUS also facilitates the addition of new techniques as required, allowing the use of existing lasers in new microscopes while retaining the ability to run the established parts of the facility. To date, techniques interlinked are multi-photon/multicolour confocal fluorescence lifetime imaging for several modalities of fluorescence resonance energy transfer (FRET) and time-resolved anisotropy, total internal reflection fluorescence, single molecule imaging of single pair FRET, single molecule fluorescence polarisation, particle tracking, and optical tweezers. Here, we use a well-studied system, the epidermal growth factor receptor network, to illustrate how OCTOPUS can aid in the investigation of complex biological phenomena. | The value of metadata to the scientist is well known: with the right choice of metadata, data files can be selected very quickly without having to scan through huge volumes of data. The ICAT metadata catalog[1] (which is part of the ICAT project[2]) allows the scientist to store and query information about individual data files and sets of data files as well as storing provenance information. This paper explains how a generic job management system, exposed as a web portal, has been built on top of ICAT. This gives the scientist easy access to a high performance computing infrastructure without allowing the complexities of that infrastructure to impede progress. The aim was to build a job and data management portal capable of dealing with batch and interactive work that would be simple to use and that was based on tried and tested, scalable, and preferably open source technologies. For the team operating the portal, it needed to be generic and configurable enough so that they can, without too much effort, modify their software to run within the portal, add new software, and create new dataset types and parameters. Modifications to existing software should be limited to saving and loading their datasets in a slightly different way so that instead of just being saved to disk, they are registered within the system along with recording any provenance information. | Motivation: As α-helical transmembrane proteins constitute roughly 25% of a typical genome and are vital parts of many essential biological processes, structural knowledge of these proteins is necessary for increasing our understanding of such processes. Because structural knowledge of transmembrane proteins is difficult to attain experimentally, improved methods for prediction of structural features of these proteins are important. Results: OCTOPUS, a new method for predicting transmembrane protein topology is presented and benchmarked using a dataset of 124 sequences with known structures. Using a novel combination of hidden Markov models and artificial neural networks, OCTOPUS predicts the correct topology for 94% of the sequences. In particular, OCTOPUS is the first topology predictor to fully integrate modeling of reentrant/membrane-dipping regions and transmembrane hairpins in the topological grammar. Availability: OCTOPUS is available as a web server at http://octopus.cbr.su.se. Contact: [email protected] Supplementary information: Supplementary data are available at Bioinformatics online. | eng_Latn | 19,237 |
Type III protein secretion systems are unique bacterial nanomachines with the capacity to deliver bacterial effector proteins into eukaryotic cells. These systems are critical to the biology of many pathogenic or symbiotic bacteria for insects, plants, animals, and humans. Essential components of these systems are multiprotein envelope-associated organelles known as the needle complex and a group of membrane proteins that compose the so-called export apparatus. Here, we show that components of the export apparatus associate intimately with the needle complex, forming a structure that can be visualized by cryo-electron microscopy. We also show that formation of the needle complex base is initiated at the export apparatus and that, in the absence of export apparatus components, there is a significant reduction in the levels of needle complex base assembly. Our results show a substantial coordination in the assembly of the two central elements of type III secretion machines. | Type III protein secretion machines have evolved to deliver bacterially encoded effector proteins into eukaryotic cells. Although electron microscopy has provided a detailed view of these machines in isolation or fixed samples, little is known about their organization in live bacteria. Here we report the visualization and characterization of the Salmonella type III secretion machine in live bacteria by 2D and 3D single-molecule switching superresolution microscopy. This approach provided access to transient components of this machine, which previously could not be analyzed. We determined the subcellular distribution of individual machines, the stoichiometry of the different components of this machine in situ, and the spatial distribution of the substrates of this machine before secretion. Furthermore, by visualizing this machine in Salmonella mutants we obtained major insights into the machine's assembly. This study bridges a major resolution gap in the visualization of this nanomachine and may serve as a paradigm for the examination of other bacterially encoded molecular machines. | ABSTRACTUNC-45A is an ubiquitously expressed protein highly conserved throughout evolution. Most of what we currently know about UNC-45A pertains to its role as a regulator of the actomyosin system... | eng_Latn | 19,238 |
The poleward flux of tubulin subunits through spindle microtubules is a striking and conserved phenomenon whose function and molecular components remain poorly understood. To screen for novel components of the flux machinery, we utilized RNA interference to deplete regulators of microtubule dynamics, individually and in various combinations, from S2 cells and examined the resulting impact on flux rate. This led to the identification of two previously unknown flux inhibitors, KLP59C and KLP67A, and a flux promoter, Mini-spindles. Furthermore, we find that flux rate is regulated by functional antagonism among microtubule stabilizers and destabilizers specifically at plus ends. Finally, by examining mitosis on spindles in which flux has been up- or down-regulated or restored after the codepletion of antagonistic flux regulators, we show that flux is an integral contributor to anaphase A but is not responsible for chromosome congression, interkinetochore tension, or the establishment of normal spindle length during prometaphase/metaphase. | During anaphase identical sister chromatids separate and move towards opposite poles of the mitotic spindle1,2. In the spindle, kinetochore microtubules3 have their plus ends embedded in the kinetochore and their minus ends at the spindle pole. Two models have been proposed to account for the movement of chromatids during anaphase. In the ‘Pac-Man’ model, kinetochores induce the depolymerization of kinetochore microtubules at their plus ends, which allows chromatids to move towards the pole by ‘chewing up’ microtubule tracks4,5. In the ‘poleward flux’ model, kinetochores anchor kinetochore microtubules and chromatids are pulled towards the poles through the depolymerization of kinetochore microtubules at the minus ends6. Here, we show that two functionally distinct microtubule-destabilizing KinI kinesin enzymes (so named because they possess a kinesin-like ATPase domain positioned internally within the polypeptide) are responsible for normal chromatid-to-pole motion in Drosophila. One of them, KLP59C, is required to depolymerize kinetochore microtubules at their kinetochore-associated plus ends, thereby contributing to chromatid motility through a Pac-Man-based mechanism. The other, KLP10A, is required to depolymerize microtubules at their pole-associated minus ends, thereby moving chromatids by means of poleward flux. | We report enhancement of the mechanical stability of graphene through a one-step method to disperse gold nanoparticles on the pristine graphene without any added agent. | eng_Latn | 19,239 |
Two-dimensional (2D) technology computer-aided design (TCAD) is used to analyze and compare the multi-gate digital performance of the screen-grid field effect transistor (SGrFET) with a finFET. The switching speed of the all-n-type inverter is ten times faster for the n-SGrFET than for the n-finFET, while the noise margins are ∼400 mV for a 1 V supply for both devices. The performance of the complementary inverter is similar for both devices. The multi-gate functionality of both devices is exploited to minimize the device count for NAND, NOR and XOR gates. The SGrFET XOR contains only two devices while three are needed for the finFET. The rise time of the SGrFET logic gates is found to be almost half of that of the finFET. Complete OFF states can be obtained for the SGrFET via the multiple unit cell approach. | This work presents digital noise in signal integrity and clarifies noise margin issues in digital electronics education. For the static noise margin, the traditional definition violates the basic principle of noise. The embedded rectangle method to define the static noise margin is a more reliable criterion. For the dynamic noise margin (DNM), several approaches have been evaluated. The best way to teach the student DNM is suggested. | The transcription of iron uptake and storage genes in Saccharomyces cerevisiae is primarily regulated by the transcription factor Aft1. Nucleocytoplasmic shuttling of Aft1 is dependent upon mitochondrial Fe-S cluster biosynthesis via a signaling pathway that includes the cytosolic monothiol glutaredoxins (Grx3 and Grx4) and the BolA homologue Fra2. However, the interactions between these proteins and the iron-dependent mechanism by which they control Aft1 localization are unclear. To reconstitute and characterize components of this signaling pathway in vitro, we have overexpressed yeast Fra2 and Grx3/4 in Escherichia coli. We have shown that coexpression of recombinant Fra2 with Grx3 or Grx4 allows purification of a stable [2Fe-2S](2+) cluster-containing Fra2-Grx3 or Fra2-Grx4 heterodimeric complex. Reconstitution of a [2Fe-2S] cluster on Grx3 or Grx4 without Fra2 produces a [2Fe-2S]-bridged homodimer. UV-visible absorption and CD, resonance Raman, EPR, ENDOR, Mossbauer, and EXAFS studies of [2Fe-2S] Grx3/4 homodimers and the [2Fe-2S] Fra2-Grx3/4 heterodimers indicate that inclusion of Fra2 in the Grx3/4 Fe-S complex causes a change in the cluster stability and coordination environment. Taken together, our analytical, spectroscopic, and mutagenesis data indicate that Grx3/4 and Fra2 form a Fe-S-bridged heterodimeric complex with Fe ligands provided by the active site cysteine of Grx3/4, glutathione, and a histidine residue. Overall, these results suggest that the ability of the Fra2-Grx3/4 complex to assemble a [2Fe-2S] cluster may act as a signal to control the iron regulon in response to cellular iron status in yeast. | eng_Latn | 19,240 |
We discuss herein the theory as well as some design considerations of magnetic tweezers. This method of generating force on magnetic particles bound to biological entities is shown to have a number of advantages over other techniques: forces are exerted in noncontact mode, they can be large in magnitude (order of 10 nanonewtons), and adjustable in direction, static or oscillatory. One apparatus built in our laboratory is described in detail, along with examples of experimental applications and results. | We combine traction force data with Bayesian inversion to obtain an absolute estimate of the internal stress field of a cell monolayer. The method, Bayesian inversion stress microscopy, is validated using numerical simulations performed in a wide range of conditions. It is robust to changes in each ingredient of the underlying statistical model. Importantly, its accuracy does not depend on the rheology of the tissue. We apply Bayesian inversion stress microscopy to experimental traction force data measured in a narrow ring of cohesive epithelial cells, and check that the inferred stress field coincides with that obtained by direct spatial integration of the traction force data in this quasi one-dimensional geometry. | The range of motion and output force of the often used electrostatic comb-drive with folded flexure straight guidance, as shown in Figure 1, is limited by sideways instability due to poor sideways stiffness of the folded flexure at relatively large deflections [1]. | eng_Latn | 19,241 |
Proteins take on their function in the cell by interacting with other proteins or biomolecular complexes. To study this process, computational methods, collectively named protein docking, are used to predict the position and orientation of a protein ligand when it is bound to a protein receptor or enzyme, taking into account chemical or physical criteria. This process is intensively studied to discover new biological functions for proteins and to better understand how these macromolecules take on these functions at the molecular scale. Pharmaceutical research also employs docking techniques for a variety of purposes, most notably in the virtual screening of large databases of available chemicals to select likely molecular candidates for drug design. The basic hypothesis of our work is that Virtual Reality (VR) and multimodal interaction can increase efficiency in reaching and analysing docking solutions, in addition to fully a computational docking approach. To this end, we conducted an ergonomic analysis of the protein–protein current docking task as it is carried out today. Using these results, we designed an immersive and multimodal application where VR devices, such as the three-dimensional mouse and haptic devices, are used to interactively manipulate two proteins to explore possible docking solutions. During this exploration, visual, audio, and haptic feedbacks are combined to render and evaluate chemical or physical properties of the current docking configuration. | Protein-protein complex structures have been predicted for CAPRI Rounds 3 and 5 using a reduced protein model. Proteins are represented by up to 3 pseudoatoms per amino acid. The docking approach termed ATTRACT is based on energy minimization in translational and rotational degrees of freedom of one protein with respect to another protein. The reduced protein model allows one to perform systematic docking minimization of many thousand start structures in reasonable computer time. Flexibility of critical surface side-chains can be accounted for by a multiple conformational copy approach. The multicopy approach allows simultaneous adjustment of side-chain conformations and optimization of translational and rotational degrees of freedom of one protein with respect to the partner during docking. For 3 (Targets 8, 14, and 19) out of 5 CAPRI targets, the approach resulted in predictions in close agreement with experiment [root-mean-square deviation (RMSD) of backbone atoms within 10 A of the protein-protein interface < 1.8 A]. The comparison of predicted and experimental structures of the CAPRI targets indicates that besides local conformational changes (e.g., changes in side-chain conformations), global conformational changes of the protein backbone can be critical for complex formation. These conformational changes not accounted for during docking are a likely reason for the unrealistic predictions in 2 cases (Targets 9 and 18). | Berzelius failed to make use of Faraday's electrochemical laws in his laborious determination of equivalent weights. | eng_Latn | 19,242 |
With the continuous shrinkage of feature size in semiconductor devices, the accurate and reliable metrology of these devices has become very challenging. One aspect of metrology which has posed many challenges for integrated circuits (IC) fabrication is sidewall roughness characterization. Although, sidewall roughness is one of the most critical factors that needs to be characterized and well controlled, currently there is no existing technology that can measure the sidewall roughness well. Here, we present a new 3D metrology Atomic Force Microscope (AFM) capable of high resolution sidewall roughness measurements with improved repeatability and accuracy. | During tactile surface measurements the contact point between probing tip and surface varies depending on the local surface angle. To reduce the resulting measurement deviation on high slopes a probing principle is investigated that applies a dynamic surface dependent sensor tilt. This probing process and the logics for the angle determination have been evaluated by simulation. A test stand based on a nanometer coordinate measuring machine is developed and fitted with a rotation kinematic based on stacked rotary axes. Systematic positioning deviations of the kinematic are reduced by a compensation field. The test stand has been completed and results are presented. | ABSTRACTUNC-45A is an ubiquitously expressed protein highly conserved throughout evolution. Most of what we currently know about UNC-45A pertains to its role as a regulator of the actomyosin system... | eng_Latn | 19,243 |
This article reviews recent studies of magnetic resonance imaging and magnetic resonance spectroscopy in dementia, including Alzheimer's disease, frontotemporal dementia, dementia with Lewy bodies, idiopathic Parkinson's disease, Huntington's disease, and vascular dementia. Magnetic resonance imaging and magnetic resonance spectroscopy can detect structural alteration and biochemical abnormalities in the brain of demented subjects and may help in the differential diagnosis and early detection of affected individuals, monitoring disease progression, and evaluation of therapeutic effect. | We report R2 and R2* in human hippocampus from five unfixed post-mortem Alzheimer's disease (AD) and three age-matched control cases. Formalin-fixed tissues from opposing hemispheres in a matched AD and control were included for comparison. Imaging was performed in a 600 MHz (14 T) vertical bore magnet at MR microscopy resolution to obtain R2 and R2* (62 μm × 62 μm in-plane, 80 μm slice thickness), and R1 at 250 μm isotropic resolution. R1, R2 and R2* maps were computed for individual slices in each case, and used to compare subfields between AD and controls. The magnitudes of R2 and R2* changed very little between AD and control, but their variances in the Cornu Ammonis and dentate gyrus were significantly higher in AD compared for controls (p < 0.001). To investigate the relationship between tissue iron and MRI parameters, each tissue block was cryosectioned at 30 μm in the imaging plane, and iron distribution was mapped using synchrotron microfocus X-ray fluorescence spectroscopy. A positive correlation of R2 and R2* with iron was demonstrated. While studies with fixed tissues are more straightforward to conduct, fixation can alter iron status in tissues, making measurement of unfixed tissue relevant. To our knowledge, these data represent an advance in quantitative imaging of hippocampal subfields in unfixed tissue, and the methods facilitate direct analysis of the relationship between MRI parameters and iron. The significantly increased variance in AD compared for controls warrants investigation at lower fields and in-vivo, to determine if this parameter is clinically relevant. | Intrinsically disordered proteins (IDPs) are flexible biomolecules whose essential functions are defined by their dynamic nature. Nuclear magnetic resonance (NMR) spectroscopy is ideally suited to the investigation of this behavior at atomic resolution. NMR relaxation is increasingly used to detect conformational dynamics in free and bound forms of IDPs under conditions approaching physiological, although a general framework providing a quantitative interpretation of these exquisitely sensitive probes as a function of experimental conditions is still lacking. Here, measuring an extensive set of relaxation rates sampling multiple-time-scale dynamics over a broad range of crowding conditions, we develop and test an integrated analytical description that accurately portrays the motion of IDPs as a function of the intrinsic properties of the crowded molecular environment. In particular we observe a strong dependence of both short-range and long-range motional time scales of the protein on the friction of the ... | eng_Latn | 19,244 |
Protein complexes are dynamic macromolecules that constantly dissociate into, and simultaneously are assembled from, free subunits. Dissociation rate constants, k(off), provide structural and functional information on protein complexes. However, because all existing methods for measuring k(off) require high-quality purification and specific modifications of protein complexes, dissociation kinetics has only been studied for a small set of model complexes. Here, we propose a new method, called Metabolically-labeled Affinity-tagged Subunit Exchange (MASE), to measure k(off) using metabolic stable isotope labeling, affinity purification and mass spectrometry. MASE is based on a subunit exchange process between an unlabeled affinity-tagged variant and a metabolically-labeled untagged variant of a complex. The subunit exchange process was modeled theoretically for a heterodimeric complex. The results showed that k(off) determines, and hence can be estimated from, the observed rate of subunit exchange. This study provided the theoretical foundation for future experiments that can validate and apply the MASE method. | Proteomic analysis of native protein–protein interactions in E. coli combined with protein mass spectrometry has revealed an interaction network consisting of the proteins essential to bacterial life. The network is highly conserved, providing insight into core bacterial processes, the nature of evolutionary constraints, and suitable new antimicrobial drug targets. Proteins often function as components of multi-subunit complexes. Despite its long history as a model organism1, no large-scale analysis of protein complexes in Escherichia coli has yet been reported. To this end, we have targeted DNA cassettes into the E. coli chromosome to create carboxy-terminal, affinity-tagged alleles of 1,000 open reading frames (∼ 23% of the genome). A total of 857 proteins, including 198 of the most highly conserved, soluble non-ribosomal proteins essential in at least one bacterial species, were tagged successfully, whereas 648 could be purified to homogeneity and their interacting protein partners identified by mass spectrometry. An interaction network of protein complexes involved in diverse biological processes was uncovered and validated by sequential rounds of tagging and purification. This network includes many new interactions as well as interactions predicted based solely on genomic inference or limited phenotypic data2. This study provides insight into the function of previously uncharacterized bacterial proteins and the overall topology of a microbial interaction network, the core components of which are broadly conserved across Prokaryota. | ●The conditions are officially justified not as punishment for prisoners but as an administrative measure. Prisoners are placed in control units in administrative moves and since there are no rules governing such moves (in contrast to punitive moves), prisoners are denied any due process and prison officials can incarcerate any prisoner in a control unit for as long as they choose, without having to give any reason. | eng_Latn | 19,245 |
Molecular motors are nonequilibrium open systems that convert chemical energy to mechanical work. Their energetics are essential for various dynamic processes in cells, but largely remain unknown because fluctuations typically arising in small systems prevent investigation of the nonequilibrium behavior of the motors in terms of thermodynamics. Recently, Harada and Sasa proposed a novel equality to measure the dissipation of nonequilibrium small systems. By utilizing this equality, we have investigated the nonequilibrium energetics of the single-molecule walking motor kinesin-1. The dissipation from kinesin movement was measured through the motion of an attached probe particle and its response to external forces, indicating that large hidden dissipation exists. In this short review, aiming to readers who are not familiar with nonequilibrium physics, we briefly introduce the theoretical basis of the dissipation measurement as well as our recent experimental results and mathematical model analysis and discuss the physiological implications of the hidden dissipation in kinesin. In addition, further perspectives on the efficiency of motors are added by considering their actual working environment: living cells. | Physiological processes in cells are performed efficiently without getting jammed although cytoplasm is highly crowded with various macromolecules. Elucidating the physical machinery is challenging because the interior of a cell is so complex and driven far from equilibrium by metabolic activities. Here, we studied the mechanics of in vitro and living cytoplasm using the particle-tracking and manipulation technique. The molecular crowding effect on cytoplasmic mechanics was selectively studied by preparing simple in vitro models of cytoplasm from which both the metabolism and cytoskeletons were removed. We obtained direct evidence of the cytoplasmic glass transition; a dramatic increase in viscosity upon crowding quantitatively conformed to the super-Arrhenius formula, which is typical for fragile colloidal suspensions close to jamming. Furthermore, the glass-forming behaviors were found to be universally conserved in all the cytoplasm samples that originated from different species and developmental stages; they showed the same tendency for diverging at the macromolecule concentrations relevant for living cells. Notably, such fragile behavior disappeared in metabolically active living cells whose viscosity showed a genuine Arrhenius increase as in typical strong glass formers. Being actively driven by metabolism, the living cytoplasm forms glass that is fundamentally different from that of its non-living counterpart. | We prove that groups acting geometrically on delta-quasiconvex spaces contain no essential Baumslag-Solitar quotients as subgroups. This implies that they are translation discrete, meaning that the translation numbers of their nontorsion elements are bounded away from zero. | eng_Latn | 19,246 |
Centrosome cohesion and separation are regulated throughout the cell cycle, but the underlying mechanisms are not well understood. Since overexpression of a protein kinase, Nek2, is able to trigger centrosome splitting (the separation of parental centrioles), we have surveyed a panel of centrosome-associated kinases for their ability to induce a similar phenotype. Cdk2, in association with either cyclin A or E, was as effective as Nek2, but several other kinases tested did not significantly interfere with centrosome cohesion. Centrosome splitting could also be triggered by inhibition of phosphatases, and protein phosphatase 1α (PP1α) was identified as a likely physiological antagonist of Nek2. Furthermore, we have revisited the role of the microtubule network in the control of centrosome cohesion. We could confirm that microtubule depolymerization by nocodazole causes centrosome splitting. Surprisingly, however, this drug-induced splitting also required kinase activity and could specifically be suppressed by a dominant-negative mutant of Nek2. These studies highlight the importance of protein phosphorylation in the control of centrosome cohesion, and they point to Nek2 and PP1α as critical regulators of centrosome structure. | Intracellular organization depends on a variety of molecular assembly processes; while some of these have been studied in simplified cell-free systems, others depend on the confined geometry of cells and cannot be reconstructed using bulk techniques. To study the latter processes in vitro, we fabricated microscopic chambers that simulate the closed environment of cells. We used these chambers to study the positioning of microtubule asters. Microtubule assembly alone, without the action of molecular motors, is sufficient to position asters. Asters with short microtubules move toward the position expected from symmetry; however, once the microtubules become long enough to buckle, symmetry is broken. Calculations and experiments show that the bending-energy landscape has multiple minima. Microtubule dynamic instability modifies the landscape over time and allows asters to explore otherwise inaccessible configurations. | We prove that groups acting geometrically on delta-quasiconvex spaces contain no essential Baumslag-Solitar quotients as subgroups. This implies that they are translation discrete, meaning that the translation numbers of their nontorsion elements are bounded away from zero. | eng_Latn | 19,247 |
Multiplexing strategies, which greatly increase the number of simultaneously measured parameters in single experiments, are now being widely implemented by both the pharmaceutical industry and acad... | Cellular functions emerge from the collective action of a large number of different proteins. Understanding how these protein networks operate requires monitoring their components in intact cells. Due to intercellular and intracellular molecular variability, it is important to monitor simultaneously multiple components at high spatiotemporal resolution. However, inherent trade-offs narrow the boundaries of achievable multiplexed imaging. Pushing these boundaries is essential for a better understanding of cellular processes. Here the motivations, challenges and approaches for multiplexed imaging of intracellular protein networks are discussed. © 2016 International Society for Advancement of Cytometry. | Berzelius failed to make use of Faraday's electrochemical laws in his laborious determination of equivalent weights. | eng_Latn | 19,248 |
The regulated accumulation of the contact-dependent extracellular C-signal morphogen in the bacterium Myxococcus xanthus ensures the temporal and spatial coordination of multicellular morphogenesis and cellular differentiation during fruiting body formation. Synthesis of the C-signal depends on the csgA gene. The CsgA protein exists in two forms, the full-length 25-kD protein (p25), which is homologous to short-chain alcohol dehydrogenases, and a 17-kD protein (p17). The molecular nature of the C-signal has remained elusive. Here we show that p25 and p17 are associated with the outer membrane and that p17 copurifies with C-signal activity from M. xanthus cells. p17 corresponds to the C-terminal part of p25. A recombinant p17 protein, which lacks the N-terminal coenzyme binding pocket and which fails to bind NAD+ in vitro, has C-signal activity. These data provide evidence that p17 is the active species in C-signaling and that p17 does not act as a short-chain alcohol dehydrogenase to generate the C-signal. We further provide evidence that p17 is synthesized by N-terminal proteolytic processing of p25 by a serine protease. Compared to other bacterial signaling molecules, p17 is unusual with respect to size and cell-surface association. In these regards, C-signal is functionally analogous to eukaryotic signaling proteins. | A large number of nonmotile mutants of the gliding bacterium Myxococcus xanthus have been isolated and partly characterized. About [unk] of these mutants are conditional mutants of a novel kind: mutant cells become transiently motile after contact with nonmutant cells or with cells of a different mutant type. These "stimulatable" mutants fall into five phenotypic classes (types B, C, D, E, and F). Most mutants are nonstimulatable (type A) and never become motile, but type A cells (and wild-type cells) can stimulate cells of any of the other five types. Stimulatable mutants of different types are capable of stimulating each other. For example, in a mixture of B and C cells, both become motile. Linkage analysis using a generalized transducing phage has shown that each of types B, C, D, E, and F corresponds to a single distinct genetic locus. Type A mutants, by contrast, belong to at least 17 different loci. Stimulation depends on close apposition of interacting cells, because stimulation does not occur when contact between cells is prevented. It is possible that the stimulatable mutants are defective in components of the gliding mechanism that can be exchanged between cells. Alternatively, they may be defective in a system of cell communication controlling the coordinated cell movements observed in Myxococcus. | We describe computer methods of simulation of Tavis-Cummings based quantum models, and apply those methods to specific tasks, conductivity measurements of atomic excitations in short chains of optical cavities with two-level atoms, C-Sign optical model, and dark states. For the conductivity measurements, we reproduce the dephasing assisted transport and quantum bottleneck effects and show their relation, and study the "which way?" problem. For the C-Sign optical model, we use the model to find optimal parameters of the system to minimize the error. For dark states, we study their collapse due to dephasing noise. | eng_Latn | 19,249 |
Human immunodeficiency virus type 1 (HIV-1) infection depends on efficient intracytoplasmic transport of the incoming viral core to the target cell nucleus. Evidence suggests that this movement is facilitated by the microtubule motor dynein, a large multiprotein complex that interacts with dynactin and cargo-specific adaptor proteins for retrograde movement via microtubules. Dynein adaptor proteins are necessary for activating dynein movement and for linking specific cargoes to dynein. We hypothesized that HIV-1 engages the dynein motor complex via an adaptor for intracellular transport. Here, we show that small interfering RNA depletion of the dynein heavy chain, components of the dynactin complex, and the dynein adaptor BICD2 reduced cell permissiveness to HIV-1 infection. Cell depletion of dynein heavy chain and BICD2 resulted in impaired HIV-1 DNA accumulation in the nucleus and decreased retrograde movement of the virus. Biochemical studies revealed that dynein components and BICD2 associate with capsid-like assemblies of the HIV-1 CA protein in cell extracts and that purified recombinant BICD2 binds to CA assemblies in vitro Association of dynein with CA assemblies was reduced upon immunodepletion of BICD2 from cell extracts. We conclude that BICD2 is a capsid-associated dynein adaptor utilized by HIV-1 for transport to the nucleus.IMPORTANCE During HIV-1 infection, the virus must travel across the cytoplasm to enter the nucleus. The host cell motor protein complex dynein has been implicated in HIV-1 intracellular transport. We show that expression of the dynein heavy chain, components of the dynein-associated dynactin complex, and the dynein adaptor BICD2 in target cells are important for HIV-1 infection and nuclear entry. BICD2 interacts with the HIV-1 capsid in vitro, suggesting that it functions as a capsid-specific adaptor for HIV-1 intracellular transport. Our work identifies specific host proteins involved in microtubule-dependent HIV-1 intracellular transport and highlights the BICD2-capsid interaction as a potential target for antiviral therapy. | Lissencephaly-1 (Lis1) is a key cofactor for dynein-mediated intracellular transport towards the minus-ends of microtubules (MTs). It remains unclear whether Lis1 serves as an inhibitor or an activator of mammalian dynein motility. Here we use single-molecule imaging and optical trapping to show that Lis1 does not directly alter the stepping and force production of individual dynein motors assembled with dynactin and a cargo adaptor. Instead, Lis1 binding releases dynein from its auto-inhibited state and thereby promotes the formation of an active complex with dynactin. Lis1 also favors recruitment of two dyneins to dynactin, resulting in increased velocity, higher force production and more effective competition against kinesin in a tug-of-war. Lis1 dissociates from motile complexes, indicating that its primary role is to orchestrate the assembly of the transport machinery. These results provide a mechanistic explanation for why Lis1 is required for efficient transport of many dynein-associated cargoes in cells. | We prove that groups acting geometrically on delta-quasiconvex spaces contain no essential Baumslag-Solitar quotients as subgroups. This implies that they are translation discrete, meaning that the translation numbers of their nontorsion elements are bounded away from zero. | eng_Latn | 19,250 |
STIFF ELBOW TREATMENT BY INTERPOSING ARTHROPLASTY ASSOCIATED TO HINGED EXTERNAL FIXATOR | Biomechanical basis for elbow hinge-distractor design. | SNARE Function Is Not Involved in Early Endosome Docking | yue_Hant | 19,251 |
Reaction-diffusion in the NEURON simulator | Computational Models of Neuronal Biophysics and the Characterization of Potential Neuropharmacological Targets | Efficient algebraic solution of reaction–diffusion systems for the cardiac excitation process | eng_Latn | 19,252 |
Understanding barrier function of the skin | Making Sense of Skin Color in Clinical Care | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,253 |
Minimal yet measurable foliations | Measure Rigidity and Disintegration: Time-one map of flows | Widespread evidence for horizontal transfer of transposable elements across Drosophilagenomes | eng_Latn | 19,254 |
Maximum Clique in Disk-Like Intersection Graphs | Optimization and Approximation on Systems of Geometric Objects | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,255 |
Molecular spinless energies of the improved Rosen-Morse potential energy model in D dimensions | Solutions of the Klein–Gordon equation with the improved Tietz potential energy model | Evidence against a role for platelet-derived molecules in liver regeneration after partial hepatectomy in humans | eng_Latn | 19,256 |
The Sloan Digital Sky Survey extended point spread functions | Astronomical Society of the Pacific Conference Series | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,257 |
The 3-D Green's function and the moment method for stripline circuits | Accurate microstrip computation through minor refinements of the 3-D quasi-dynamic greens function | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,258 |
Segmentation of Vector Field Using Green Function and Normalized Cut | Representation and display of vector field topology in fluid flow data sets | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,259 |
Behavior Of Closely Jointed Rock | The Rock Mass index ( RMÐ applied in rock mechanics and rock engineering | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,260 |
Recurrent networks for compressive sampling | KKT condition-based smoothing recurrent neural network for nonsmooth nonconvex optimization in compressed sensing | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,261 |
Some Theorems on Detachments Preserving Local-Edge-Connectivity | A Detachment Algorithm for Inferring a Graph from Path Frequency | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,262 |
Solid-state NMR evidence for elastin-like β-turn structure in spider dragline silk | Analysis of repetitive amino acid motifs reveals the essential features of spider dragline silk proteins | Backstepping control of the Stefan problem with flowing liquid | eng_Latn | 19,263 |
Uplink-Downlink Duality for Integer-Forcing | A rate-splitting approach to the Gaussian multiple-access channel | SNARE Function Is Not Involved in Early Endosome Docking | yue_Hant | 19,264 |
A Multiplexed NMR-Reporter Approach to Measure Cellular Kinase and Phosphatase Activities in Real-Time | Quo Vadis Biomolecular NMR Spectroscopy? | Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling | eng_Latn | 19,265 |
Bagging down-weights leverage points | Why Does Bagging Work? A Bayesian Account and its Implications | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,266 |
The inner equation for one and a half degrees of freedom rapidly forced Hamiltonian systems | Breakdown of heteroclinic orbits for some analytic unfoldings of the Hopf-zero singularity | TPA-induced inhibition of gap junctional intercellular communication is not mediated through free radicals. | eng_Latn | 19,267 |
Resonant tunneling and Fano resonance in quantum dots with electron-phonon interaction | Dephasing of electrons in the Aharonov-Bohm interferometer with a single-molecular vibrational junction | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,268 |
Haptic-based volumetric modeling using spline-based dynamic implicit functions | Constructive sculpting of heterogeneous volumetric objects using trivariate B-splines | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,269 |
A task analysis of hemispheric functioning | The Boulder model: history, rationale, and critique | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,270 |
A NEW APPROACH FOR EVALUATING THE RANKINE CYCLE THROUGH ENTROPY GENERATION | Low-grade heat conversion into power using organic Rankine cycles – A review of various applications | SNARE Function Is Not Involved in Early Endosome Docking | yue_Hant | 19,271 |
APPROXIMATION BY BOUNDARY VALUES OF ANALYTIC FUNCTIONS | General Mean Modulus of Analytic Functions | SNARE Function Is Not Involved in Early Endosome Docking | yue_Hant | 19,272 |
Symmetric Markov chains on $\Bbb Z^d$ with unbounded range | Multidimensional diffusion processes | Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling | eng_Latn | 19,273 |
Hypercube and shuffle-exchange algorithms for image component labeling | Dynamic computational geometry on meshes and hypercubes | High-affinity glucose uptake in Saccharomyces cerevisiae is not dependent on the presence of glucose-phosphorylating enzymes | eng_Latn | 19,274 |
Collective cell migration over long time scales reveals distinct phenotypes | Phenomenological approaches to collective behavior in epithelial cell migration. | Surges of collective human activity emerge from simple pairwise correlations | eng_Latn | 19,275 |
AN EDUCATIONAL PROGRAM FOR FREEWAY OPERATIONS ANALYSIS | INTEGRATED SYSTEM OF FREEWAY CORRIDOR SIMULATION MODELS | SNARE Function Is Not Involved in Early Endosome Docking | yue_Hant | 19,276 |
Scanning camera for continuous-wave acoustic holography | Using the Discrete Dipole Approximation and Holographic Microscopy to Measure Rotational Dynamics of Non-spherical Colloidal Particles | Transcriptional activation of HIF-1 by a ROS-ERK axis underlies the resistance to photodynamic therapy | eng_Latn | 19,277 |
Chain conformation in nematic elastomers | Stacking nematic elastomers for artificial muscle applications | Arginine methylation of the HIV-1 nucleocapsid protein results in its diminished function. | eng_Latn | 19,278 |
Conservation between human and fungal squalene synthetases: similarities in structure, function | Targeted selection of recombinant clones through gene dosage effects. | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,279 |
Nested Rollout Policy Adaptation with Selective Policies | Monte-Carlo Fork Search for Cooperative Path-Finding | High-affinity glucose uptake in Saccharomyces cerevisiae is not dependent on the presence of glucose-phosphorylating enzymes | eng_Latn | 19,280 |
Facet Embeddings for Explorative Analytics in Digital Libraries | Digital Visual Exploration Library | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,281 |
Graph-Theoretic Techniques for Macromolecular Docking | Kinematics and Workspace Analysis of Protein Based Nano-Actuators | SNARE Function Is Not Involved in Early Endosome Docking | kor_Hang | 19,282 |
Application of ARCS Model and Motivational Design in Engineering Subjects – A Case Study | The systematic process of motivational design | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,283 |
Fatigue crack localization with near-field acoustic emission signals | Source location in thin plates using cross‐correlation | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,284 |
A Bright Light to Reveal Mobility: Single Quantum Dot Tracking Reveals Membrane Dynamics and Cellular Mechanisms. | Chemical Structure, Ensemble and Single-Particle Spectroscopy of Thick-Shell InP–ZnSe Quantum Dots | A Mechanical Feedback Restricts Sepal Growth and Shape in Arabidopsis | kor_Hang | 19,285 |
The bidirectional depolymerizer MCAK generates force by disassembling both microtubule ends | Identification and partial characterization of mitotic centromere- associated kinesin, a kinesin-related protein that associates with centromeres during mitosis | Radar backscatter is not a 'direct measure' of forest biomass | eng_Latn | 19,286 |
Machine learning for protein folding and dynamics | Molecular enhanced sampling with autoencoders: On-the-fly collective variable discovery and accelerated free energy landscape exploration | Exogenous growth factors do not affect the development of individually cultured murine embryos | eng_Latn | 19,287 |
Gap Probabilities in Non-Hermitian Random Matrix Theory | Territorial behaviour of buzzards versus random matrix spacing distributions | HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochore | eng_Latn | 19,288 |
First-passage-time statistics in disordered media. | Structural and temporal heterogeneities on networks | TPA-induced inhibition of gap junctional intercellular communication is not mediated through free radicals. | eng_Latn | 19,289 |
A Finite Element Method for computing Shear Band formation | Computation of large shear deformations of a thermoplastic material | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,290 |
An (H)C(CO)NH-TOCSY pulse scheme for sequential assignment of protonated methyl groups in otherwise deuterated (15)N, (13)C-labeled proteins. | Multidimensional NMR Methods for Protein Structure Determination | Completely Stale Transmitter Channel State Information is Still Very Useful | eng_Latn | 19,291 |
On finite time mechanism: terminal sliding modes | Fast Terminal Sliding Mode Control for Gantry Cranes | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,292 |
Entry-Exit event detection and learning | Histograms of oriented gradients for human detection | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,293 |
Tensor product model for a Reverse Osmosis system | Tensor Product Model Transformation in Polytopic Model-Based Control | Delayed Reactive Distractor Suppression in Aging Populations | eng_Latn | 19,294 |
Evidence-Based Optimization of Urban Firefighter First Response to Emergency Medical Services 9-1-1 Incidents | Optimal defibrillation response intervals for maximum out-of-hospital cardiac arrest survival rates | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,295 |
Dynamical Relation between Quantum Squeezing and Entanglement in Coupled Harmonic Oscillator System | Threshold effect and entanglement enhancement through local squeezing of initial separable states in continuous-variable systems | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,296 |
SIXTH FRAMEWORK PROGRAMME EURATOM IP EUROTRANS Domain ECATS Work Package 2 . 3 : GUINEVERE Shielding and Fuel Storage Calculations for GUINEVERE | Comparison of MCNP5 and experimental results on neutron shielding effects for materials | SNARE Function Is Not Involved in Early Endosome Docking | yue_Hant | 19,297 |
FLEXIBILITY AND FUNCTION IN HIV PROTEASE : DYNAMICS OF THE HIV-1 PROTEASE BOUND TO THE ASYMMETRIC INHIBITOR KYNOSTATIN 272 (KNI-272) | Investigation on the mechanism for the binding and drug resistance of wild type and mutations of G86 residue in HIV-1 protease complexed with Darunavir by molecular dynamic simulation and free energy calculation | SNARE Function Is Not Involved in Early Endosome Docking | yue_Hant | 19,298 |
An hybrid approach to accelerate a molecular docking application for virtual screening in heterogeneous nodes: POSTER | mARGOt: A Dynamic Autotuning Framework for Self-Aware Approximate Computing | SNARE Function Is Not Involved in Early Endosome Docking | eng_Latn | 19,299 |
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