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In 1960 Ginsburg edited the book Non-Benzenoid Aromatic Compounds. Two years later he authored Opium Alkaloids: Selected Topics, published by Interscience Publishers. He also wrote: Structure and Reactions, Weinheim: Verlag Chemie (Monographs in Modern Chemistry, v. 7), Propellanes: Structure and Reactions: sequel I (July 1975-December 1980), Haifa: Technion-Israel Institute of Technology, Department of Chemistry, 1981. ( the book is a continuation of the book by that name appeared Boweinheim in 1975; presented in articles published between July 1, 1975 to December 31, 1980.
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Genome-wide association studies (GWAS) and exome sequencing from subjects in the UK Biobank show that gene polymorphism and mutations in ZIP12 are associated with altered susceptibility weighted imaging intensity and T1 FAST magnetic resonance imaging (MRI) in the human brain. Polymorphisms (rs10430577, rs10430578) near SLC39A12 are the lead single nucleotide polymorphisms (SNPs) most associated with altered swMRI intensity in the caudate, putamen, and pallidum and T1 FAST MRI in the putamen. Susceptibility weighted magnetic resonance imaging is sensitive to metal content in the tissues analyzed. Associated missense ZIP12 mutations (rs10764176, rs72778328) have reduced zinc transport activity when measured in Chinese hamster ovary (CHO) cells. However, the impact of the changes in the human brain caused by ZIP12 polymorphisms and mutations is currently unknown.
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These sessions are financed through European Commission Comenius national Agencies (Comenius programme). Information related to scheduled training sessions is posted on the EU-HOU website and its news.
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https://en.wikipedia.org/wiki?curid=20430586
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His papers were issued in both national and international prestigious professional research scientific journals, and numerous scientific articles and books were published.
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Following extensive European travel in the 1920s, Oesper began writing and compiling biographies of notable European chemists. These biographies were published in the United States in 1929 in a journal article entitled "What a Chemist May See in Europe". The publication included 24 biographies, examples including Fritz Haber, Alfred Nobel, Wilhelm Ostwald, Joseph Priestley, among others.
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In 1972 Ginsburg received the Israel Prize for Exact Sciences. In 1954 he received the Weizmann Prize for Exact Sciences Research and in 1965, the Rothschild Prize.
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Hypoxia induces the expression of ZIP12 in the endothelium of mammalian pulmonary vessels. The induction of ZIP12 results in the proliferation and thickening of pulmonary vascular smooth muscle cells, which leads to pulmonary hypertension. Zhao et al. identified ZIP12 as the responsible gene through congenic breeding between Fisher 344 (F344) rats, which are resistant to hypoxia-induced pulmonary hypertension, and susceptible Wistar Kyoto (WKY) rats. Resistant F344 rats crossed with non-resistant WKY rats produce subcongenic strains, and quantitative trait loci (QTL) analysis was used to determine which genes co-segregate with the hypoxic response by the pulmonary vessels and sensitivity to pulmonary hypertension. A ZIP12 frameshift mutation in F344 rats truncates the protein and reduces cellular zinc uptake by pulmonary endothelial smooth muscle cells. Additional support for ZIP12 as the responsible gene was shown when a similar resistance to hypoxia-induced pulmonary hypertension was observed in rats with targeted deletion of the SLC39A12 (ZIP12) gene by zinc finger nucleases. In addition to rats, cattle and humans also show increased ZIP12 protein when housed in hypoxic environments, which implies that response of increased ZIP12 protein to hypoxia is found across different mammals. A hypoxia response element (HRE) is present within a SLC39A12 intron, which can increase ZIP12 expression under hypoxic conditions. In a separate study using human vascular endothelial and smooth muscle cells, ZIP12 expression increased after intracellular zinc chelation by TPEN.
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A dedicated forum in English has been opened to favour feedback from trained teachers and interaction with a wider educator and researcher community.
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https://en.wikipedia.org/wiki?curid=20430586
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He presented his talks at several conferences and at the different science forums and he developed significant research and professional relationships in Western, Central and Eastern Europe.
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As part of his career as a researcher in analytical chemistry, in 1938 Oesper translated a significant treatise on analytical methods from the German language into English, thereby making the information more broadly available. From then, Oesper continued to translated important scientific works.
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Associations between ZIP12 and schizophrenia have been reported. A non-coding polymorphism in ZIP12 has been described as being more prevalent in patients with schizophrenia, although this finding has not yet been replicated in other studies. In another study using genome-wide microarrays and post-mortem brain tissue, researchers found higher abundance of ZIP12 mRNA in frontal lobe, superior frontal gyrus, and inferior frontal gyrus of brains from schizophrenic subjects. Higher expression of both splice variants of ZIP12 was detected in the brains of patients with schizophrenia.
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His three main fields of interest are in Algebra: theory of Abelian groups, theory of Modules and theory of Rings. He was also interested in the history of mathematics.
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https://en.wikipedia.org/wiki?curid=60000531
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Oesper wrote numerous short biographies of notable chemists and lectured on the history of chemistry. Particularly notable was his 1975 book "The Human Side of Scientists", which emphasized the lives of the scientists over their scientific contributions "per se". The book includes 138 short biographies of scientists, mostly chemists.
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https://en.wikipedia.org/wiki?curid=61091681
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Mutations and copy number variations in SLC39A12 have been reported for autism, although it is unclear whether genetic variability contributes towards autism risk. In one study assessing copy number variations in Han Chinese subjects with autism, one person had a heterozygous deletion in SLC39A12. In another study, a premature stop codon was detected in one copy of SLC39A12 for one autistic subject.
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https://en.wikipedia.org/wiki?curid=54312100
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During his visiting professorship in Halle, East Germany he contributed to the discovery of the mathematical achievements of Georg Cantor, too.
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https://en.wikipedia.org/wiki?curid=60000531
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In 1954, Oesper received the 5th annual Eminent Chemist award by the American Chemical Society. In 1956 he received the first Dexter Award for Outstanding Achievement in the History of Chemistry from the American Chemical Society. In 1966 he was awarded an honorary doctorate by the University of Cincinnati.
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https://en.wikipedia.org/wiki?curid=61091681
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Altered expression and mutations in ZIP12 have been detected in various cancers. In 145 patients with esophageal adenocarcinoma, whole exome sequencing found that 12 patients had ZIP12 missense mutations in tumors negative for microsatellite instability. Coding mutations in ZIP12 were also detected in a separate study on esophageal adenocarcinoma. Differences in ZIP12 expression has been reported in different cancers. ZIP12 mRNA was elevated in non-small cell lung cancer biopsied tissues from at least half of tested patients. ZIP12 protein abundance was lower in the breast cancer lines T47D and MDA-MB-231 when compared to non-malignant mammary cell line MCF10A.
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At the Martin Luther University of Halle-Wittenberg he had a great role in the establishment of the Modern algebraic school.
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https://en.wikipedia.org/wiki?curid=60000531
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Oesper was a member of the editorial boards of the Journal of Chemical Education, Chymia, Mikrochemie, and Microchimica Acta.
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https://en.wikipedia.org/wiki?curid=61091681
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Associations of ZIP12 with additional diseases or physiological functions have been reported. In broiler male chicks, ZIP12 mRNA expression in the duodenum, a region of the small intestine, decreases in response to an oral challenge with Salmonella. ZIP12 mRNA and protein increased in lung and liver of chickens after ascites syndrome by intravenous cellulose microparticle injection. The restoration of zinc to zinc-deficient T-cells induces ZIP12 expression, which may promote cytokine production by the immune system. Using quantitative trait loci (QTL) mapping in 2 different cow strains, SLC39A12 (ZIP12) may be a candidate gene that affects fertility in female Chinese and Nordic Holstein cows. ZIP12 mRNA is more abundant in mouse oocytes compared to cumulus cells, which indicates that ZIP12 may play a role in reproduction and fertility. A genome-wide association study (GWAS) in horses has linked an intronic polymorphism in SLC39A12 to endurance racing performance in Arabian horses. One study reported that fasting glucose is associated with two polymorphisms in the SLC39A12 gene, although these findings have not been confirmed in other studies and ZIP12 expression has not been detected in the pancreas.
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His father, Lajos Kertész (1899–1974) was a teacher of music. His mother was Mária Nyíri. He had three siblings. Andor Kertész's wife was Ilona Tóth, teacher of history and geography. They had two children, a daughter, physician Gabriella Kertész and a son, linguist András Kertész.
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Oesper bequeathed his extensive library to the University of Cincinnati. This included a financial endowment to fund projects on the history of chemistry. The University of Cincinnati with the Cincinnati section of the American Chemical Society present an annual Oesper Award and Symposium series, named in Ralph Oesper's honor.
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The 14th South American Junior Championships in Athletics were held in Rio de Janeiro, Brazil from October 15–18, 1981.
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William Glen, Ph.D. (born 1932) is a geologist and historian of science. He is a former editor-at-large at Stanford University Press, former visiting scientist/historian at the U.S. Geological Survey, Menlo Park, and is currently visiting scholar at Stanford University in California.
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https://en.wikipedia.org/wiki?curid=4554607
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Tetrahydrosarcinapterin synthase (, "H4MPT:alpha-L-glutamate ligase", "MJ0620", "MptN protein") is an enzyme with systematic name "tetrahydromethanopterin:alpha-L-glutamate ligase (ADP-forming)". This enzyme catalyses the following chemical reaction
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Adenosylcobinamide-phosphate synthase (, "CbiB") is an enzyme with systematic name "adenosylcobyric acid:(R)-1-aminopropan-2-yl phosphate ligase (ADP-forming)". This enzyme catalyses the following chemical reaction
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The 1926 European Rowing Championships were rowing championships held on Lake Lucerne in the Swiss city of Lucerne. The competition was for men only and they competed in all seven Olympic boat classes (M1x, M2x, M2-, M2+, M4-, M4+, M8+).
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The 1903 European Rowing Championships were rowing championships held in Giudecca, an island in the Venetian Lagoon, on the Giudecca Canal on a day in the middle of August. The competition was for men only and they competed in five boat classes (M1x, M2x, M2+, M4+, M8+).
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María Guadalupe Sánchez (born August 4, 1995) is a Mexican racewalker. She placed 23rd in the women's 20 kilometres walk at the 2016 Summer Olympics.
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Professor John Guest Phillips FRS FZS (13 June 1933 – 14 March 1987) was an eminent biologist. He was born in Swansea and educated at Llanelli Boys' Grammar School and the University of Liverpool; where, after gaining his BSc, he joined the research group of Chester Jones to complete a PhD in endocrinology. Following his doctorate he took up a fellowship at the Bingham Oceanographic Laboratory at Yale University with Grace E. Pickford. After a lectureship at Sheffield University Phillips was appointed to the Chair of Zoology at the University of Hong Kong. He returned to the UK to become Professor of Zoology, from 1967–79, and Dean of the Faculty of Science (1978-1980) at the University of Hull, Director of the Wolfson Institute for Gerontology (1979-1986) (located at the University of Hull) and later Vice-Chancellor of Loughborough University from 1986-1987. He was secretary of the Zoological Society of London. Phillips' research was predominantly in the fields of endocrinology, notably concerning the salt glands of sea birds, and the biological basis of ageing (gerontology).
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Hypericum aucheri, also known as Koramanotu in Turkish, is a herbaceous perennial flowering plant in the St. John's wort family Hypericaceae.
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https://en.wikipedia.org/wiki?curid=59957991
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Andrew Adibo Dick (born 11 May 1976 in Abeokuta, Ogun) is an amateur freestyle wrestler from Nigeria, who competes in the men's light heavyweight category. At the age of thirty-six, Dick made his Olympic debut in the 2012 Summer Olympics in London, where he competed in the 84 kg class in men's freestyle wrestling. He lost his first match in the preliminary round to Puerto Rico's Jaime Espinal, with a technical score of 1–9, and a classification score of 1–3. Because Espinal advanced further into the final match against Azerbaijan's Sharif Sharifov, Dick was offered another shot for the bronze medal through the repechage bouts. He withdrew from the competition because of a serious injury, allowing his opponent Dato Marsagishvili of Georgia to qualify directly for the bronze medal bout.
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Crambus albellus, the small white grass-veneer, is a moth in the family Crambidae. It was first described by James Brackenridge Clemens in 1860. It is found in North America, where sightings have been recorded from Quebec and Ontario to North Carolina and Tennessee, west to Illinois and Wisconsin.
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https://en.wikipedia.org/wiki?curid=43622497
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The French Institute of Urbanism ("Institut Français d'Urbanisme", IFU) was a French scientific research institute that provided post-graduate training in the fields of urban planning and spatial planning. It was hosted by the University of Marne-la-Vallée, and located on the campus Descartes, Champs-sur-Marne. Founded as the Department of Planning in the University Experimental Center of Vincennes in the middle of the year 1968-1969, it became an autonomous institute in 1976 as the "Institut d'Urbanisme de l'Académie de Paris" (IUAP), and took the name "Institut Français d'Urbanisme" in 1985.
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This gene encodes a multi-pass membrane protein with a major sperm protein (MSP) domain. The deletion of a similar mouse gene is associated with defective cardiac development and neonatal lethality. Alternate transcriptional splice variants, encoding different isoforms, have been described.
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https://en.wikipedia.org/wiki?curid=43798821
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Archery at the 1968 Summer Paralympics consisted of thirteen events, eight for men and five for women.
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https://en.wikipedia.org/wiki?curid=19847416
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Kathrin Altwegg is an astrophysicist, who is an Associate Professor in the Department of Space Research and Planetology, and former director of the " " (CSH) at the University of Bern. She is a member of the International Astronomical Union.
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https://en.wikipedia.org/wiki?curid=67267891
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Sweden competed at the 2019 World Championships in Athletics in Doha, Qatar, from 27 October to 4 October 2019. 24 athletes were selected to compete for Sweden.
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Christiaan Huijgens (25 January 1897 – 11 January 1963) was a Dutch long-distance runner. He competed in the marathon at the 1920 Summer Olympics.
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Coleophora monardella is a moth of the family Coleophoridae. It is found in North America, including Iowa and Ontario.
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Donald George Fleming (born November 7, 1938) is a Canadian chemist. He attended the University of British Columbia and earned a Bachelor of Science degree in 1961 and a Master of Science degree in 1961. He earned a Ph.D. at the University of California, Berkeley in 1967. He is currently a professor emeritus of chemistry at the University of British Columbia. In 1989 he published a paper theorizing a new kind of chemical bond, which he referred to as vibrational bonding. The existence of such a short-lived bond was confirmed using a reaction between bromine and the exotic atom muonium in January 2015. Fleming is also known for his work in utilizing muon beams in studies of physical chemical sciences.
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Eurybia radula, commonly known as the low rough aster or rough wood aster, is an herbaceous perennial in the family Asteraceae. It is native to eastern North America where it is present from Newfoundland and Labrador in the far northeast of Canada, west to Ontario and south to Kentucky and Virginia in the United States. The low rough aster is also present on the French overseas territory of St. Pierre and Miquelon just south of Newfoundland. It typically grows in wet soils in a wide variety of habitats from bogs and fens to creek shores to ditches. Although it is not considered threatened over most of its distribution, it is imperiled or possibly extirpated over much of its range in the United States. Its flower heads emerge in the late summer to early fall and show pale blue-violet rays with yellow centres.
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Erysimum kykkoticum is a species of flowering plant in the family Brassicaceae. It is endemic to the Mediterranean island of Cyprus. Its natural habitats are Mediterranean-type shrubby vegetation and rocky areas. It is threatened by habitat loss.
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https://en.wikipedia.org/wiki?curid=12350492
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The 2017–18 Biathlon World Cup – Stage 6 was the 6th event of the season and was held in Antholz, Italy, from 18 January until 21 January 2018.
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Athetini is a tribe of rove beetles in the family Staphylinidae. There are at least 50 genera and 430 described species in Athetini.
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James Alexander Murray (fl. 1841-1893) was a British zoologist, taxidermist, and museum curator in Karachi. He published several books including one on the edible birds of India and founded the Victoria Natural History Institute at Bombay but went bankrupt, was imprisoned, and died in obscurity.
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https://en.wikipedia.org/wiki?curid=4924563
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Favartia nivea is a species of sea snail, a marine gastropod mollusc in the family Muricidae, the murex snails or rock snails.
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Hastula daniae is a species of sea snail, a marine gastropod mollusk in the family Terebridae, the auger snails.
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Tubulinyl-Tyr carboxypeptidase (, "carboxypeptidase-tubulin", "soluble carboxypeptidase", "tubulin-tyrosine carboxypeptidase", "tubulin carboxypeptidase", "tubulinyltyrosine carboxypeptidase", "tyrosinotubulin carboxypeptidase", "tyrosyltubulin carboxypeptidase", "TTCPase", "brain I carboxypeptidase") is an enzyme. This enzyme catalyses the following chemical reaction
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https://en.wikipedia.org/wiki?curid=39264112
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Glucuronoarabinoxylan endo-1,4-beta-xylanase (, "feraxan endoxylanase", "feraxanase", "endoarabinoxylanase", "glucuronoxylan xylohydrolase", "glucuronoxylanase", "glucuronoxylan xylanohydrolase", "glucuronoarabinoxylan 1,4-beta-D-xylanohydrolase") is an enzyme with systematic name "glucuronoarabinoxylan 4-beta-D-xylanohydrolase". This enzyme catalyses the following chemical reaction
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https://en.wikipedia.org/wiki?curid=39100765
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Fructan beta-(2,1)-fructosidase (, "beta-(2-1)-D-fructan fructohydrolase", "beta-(2-1)fructan exohydrolase", "inulinase", "1-FEH II", "1-fructan exohydrolase", "1-FEH w1", "1-FEH w2", "beta-(2-1)-linkage-specific fructan-beta-fructosidase", "beta-(2,1)-D-fructan fructohydrolase") is an enzyme with systematic name "beta-(2->1)-D-fructan fructohydrolase". This enzyme catalyses the following chemical reaction
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https://en.wikipedia.org/wiki?curid=39101103
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The enzyme fluoroacetyl-CoA thioesterase (EC 3.1.2.29; systematic name fluoroacetyl-CoA hydrolase) catalyses the following reaction:
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In 1772 he obtained his philosophy degree (magister), then received his medical doctorate in 1774. Following a study trip through Germany, France and England, he returned to Leipzig as a lecturer of physics. He died in Leipzig on 25 February 1784, age 34.
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https://en.wikipedia.org/wiki?curid=48556364
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Stephen John (born 21 June 1974) is a Pakistani cricket coach and former first-class cricketer who played for Islamabad.
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Cytosol alanyl aminopeptidase (, "arylamidase", "aminopolypeptidase", "thiol-activated aminopeptidase", "human liver aminopeptidase", "puromycin-sensitive aminopeptidase", "soluble alanyl aminopeptidase", "cytosol aminopeptidase III", "alanine aminopeptidase") is an enzyme. This enzyme catalyses the following chemical reaction
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Uncial 0213 (in the Gregory-Aland numbering) is a Greek uncial manuscript of the New Testament, dated palaeographically to the 5th or 6th century.
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https://en.wikipedia.org/wiki?curid=20292150
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Joseph Barsalou was born in Agen in the south west of France. He came from a family of apothecaries that was originally from Narbonne. Joseph Barsalou received no formal medical training. His father handed down his knowledge of herbs and minerals. It is through his friendship with the Scaliger family that Joseph Barsalou gained access to the library of Julius Caesar Scaliger and his son Joseph Justus Scaliger. Julius Caesar Scaliger was a physician, philosopher and commentator of Aristotle. His son Josephus Justus Scaliger was a scholar, linguist and historian. Joseph Barsalou built on his traditional knowledge of herbs with an introduction to medicine and philosophy reading Galen, Aristotle and Pythagoras.
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Mentzelia affinis is a species of flowering plants in the family Loasaceae known by the common name yellowcomet. It is native to the southern half of California, Arizona, and adjacent sections of Nevada and Baja California, where it is known from scrub, woodland, desert sands, and other habitat types.
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Darwinia polychroma, commonly known as harlequin bell, is a species of flowering plant in the myrtle family Myrtaceae and is endemic to Western Australia. It has linear leaves and drooping flowers surrounded by yellowish green, green and red bracts.
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https://en.wikipedia.org/wiki?curid=53109229
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In enzymology, a beta-glucan-transporting ATPase () is an enzyme that catalyzes the chemical reaction
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https://en.wikipedia.org/wiki?curid=14337256
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This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring amino groups. The systematic name of this enzyme class is (2S)-alpha-leucine 2,3-aminomutase. This enzyme participates in valine, leucine and isoleucine degradation. It employs one cofactor, cobamide.
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The 3 substrates of this enzyme are ATP, malate, and CoA, whereas its 3 products are ADP, phosphate, and malyl-CoA.
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https://en.wikipedia.org/wiki?curid=14286121
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Thus, the two substrates of this enzyme are 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one and oxygen, whereas its two products are 4-methylthio-2-oxobutanoate and formate.
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https://en.wikipedia.org/wiki?curid=14143387
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In enzymology, a tRNA (uracil-5-)-methyltransferase () is an enzyme that catalyzes the chemical reaction
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https://en.wikipedia.org/wiki?curid=14025727
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This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 3-dehydro-L-gulonate-6-phosphate carboxy-lyase (L-xylulose-5-phosphate-forming). Other names in common use include 3-keto-L-gulonate 6-phosphate decarboxylase, UlaD, SgaH, SgbH, KGPDC, and 3-dehydro-L-gulonate-6-phosphate carboxy-lyase. This enzyme participates in pentose and glucuronate interconversions and ascorbate and aldarate metabolism.
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https://en.wikipedia.org/wiki?curid=14281466
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This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is (3S)-3-methyl-2-oxopentanoate carboxy-lyase (2-methylbutanal-forming). Other names in common use include branched-chain oxo acid decarboxylase, branched-chain alpha-keto acid decarboxylase, branched-chain keto acid decarboxylase, BCKA, and (3S)-3-methyl-2-oxopentanoate carboxy-lyase.
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https://en.wikipedia.org/wiki?curid=14282061
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In enzymology, a 5-(carboxyamino)imidazole ribonucleotide synthase () is an enzyme that catalyzes the chemical reaction
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Thus, the two substrates of this enzyme are acetyl-CoA and imidazole, whereas its two products are CoA and N-acetylimidazole.
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Thus, the two substrates of this enzyme are acetyl-CoA and maltose, whereas its two products are CoA and 6-O-acetyl-alpha-D-glucopyranosyl-(1->4)-D-glucose.
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https://en.wikipedia.org/wiki?curid=14543677
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This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is 4-nitrophenylphosphate phosphohydrolase. Other names in common use include nitrophenyl phosphatase, p"-nitrophenylphosphatase, para"-nitrophenyl phosphatase, K-pNPPase, NPPase, PNPPase, Ecto-p-nitrophenyl phosphatase, and "p"-nitrophenylphosphate phosphohydrolase. This enzyme participates in γ-hexachlorocyclohexane degradation.
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https://en.wikipedia.org/wiki?curid=14453439
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This enzyme belongs to the family of hydrolases, to be specific, those acting on phosphoric monoester bonds. The systematic name is dolichyl-phosphate phosphohydrolase. Other names in common use include dolichol phosphate phosphatase, dolichol phosphatase, dolichol monophosphatase, dolichyl monophosphate phosphatase, dolichyl phosphate phosphatase, polyisoprenyl phosphate phosphatase, polyprenylphosphate phosphatase, and Dol-"P" phosphatase. This enzyme participates in "N"-linked-glycan biosynthesis.
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https://en.wikipedia.org/wiki?curid=14455502
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This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name is ("R")-3-(("R")-3-hydroxybutanoyloxy)butanoate hydroxybutanoylhydrolase. The enzyme is also called -(–)-3-hydroxybutyrate-dimer hydrolase. It participates in butanoate metabolism.
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https://en.wikipedia.org/wiki?curid=14456299
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2,244,472 |
This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name is succinyl-CoA hydrolase. Other names in common use include succinyl-CoA acylase, succinyl coenzyme A hydrolase, and succinyl coenzyme A deacylase. This enzyme participates in the tricaboxylate cycle.
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https://en.wikipedia.org/wiki?curid=14457829
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2,244,473 |
Concentrative nucleoside transporter 2 (CNT2) is a protein that in humans is encoded by the "SLC28A2" gene.
|
https://en.wikipedia.org/wiki?curid=14800246
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2,244,474 |
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 1. The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II. The structural organization of this gene also suggested that it had diverged considerably from the beta chain genes. Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that laminin, gamma 1 chain is necessary for laminin heterotrimer assembly. It has been inferred by analogy with the strikingly similar 3' UTR sequence in mouse laminin gamma 1 cDNA, that multiple polyadenylation sites are utilized in human to generate the 2 different sized mRNAs (5.5 and 7.5 kb) seen on Northern analysis.
|
https://en.wikipedia.org/wiki?curid=14754857
|
2,244,475 |
6-pyruvoyltetrahydropterin synthase, also known as PTS, is a human gene which facilitates folate biosynthesis.
|
https://en.wikipedia.org/wiki?curid=14755768
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2,244,476 |
The 2010 FIBA Europe Under-20 Championship for Women was the 9th edition of the FIBA Europe Under-20 Championship for Women. 16 teams featured the competition, held in Liepāja and Grobiņa, in Latvia, from July 15–25. France was the current title holder. Russia won the title against Spain.
|
https://en.wikipedia.org/wiki?curid=28053884
|
2,244,477 |
It is a hot Jupiter-sized planet orbiting a G9V star with T = 5440K, M = 0.95M, R = 1.00R, and near-solar metallicity. Its age is unknown.
|
https://en.wikipedia.org/wiki?curid=60066950
|
2,244,478 |
Elephter Andronikashvili Institute of Physics () is a Institute of Science based on Tbilisi State University.
|
https://en.wikipedia.org/wiki?curid=69404334
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2,244,479 |
It was established in 1953. It currently consists of two departments. The campus is across the street from Hakodate University.
|
https://en.wikipedia.org/wiki?curid=30836301
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2,244,480 |
The Canadian Entomologist is a bimonthly peer-reviewed scientific journal covering all aspects of entomology. It is published by Cambridge University Press on behalf of the Entomological Society of Canada and was established in 1868. Volumes 1 to 54 are freely accessible in the Biodiversity Heritage Library. According to the "Journal Citation Reports", the journal has a 2020 impact factor of 0.878.
|
https://en.wikipedia.org/wiki?curid=7362620
|
2,244,481 |
John James Stevenson (October 10, 1841 – August 10, 1924) was an American geologist, born in New York City. He graduated from New York University in 1863, became professor of chemistry at West Virginia University for two years (1869–71), then served as professor of geology at New York University until 1909. During 1873–74 and from 1878 to 1880 he was geologist for the United States Geological Survey. He also served on the Pennsylvania Geological Survey from 1875 to 1878 and from 1881 to 1882. He was president of the Geological Society of America in 1898.
|
https://en.wikipedia.org/wiki?curid=5634477
|
2,244,482 |
Platelet-activating factor acetylhydrolase IB subunit gamma is an enzyme that in humans is encoded by the "PAFAH1B3" gene.
|
https://en.wikipedia.org/wiki?curid=15217308
|
2,244,483 |
Handball at the 2007 Southeast Asian Games took place at the Nimibutr Gymnasium at the National Sport Complex, Bangkok, Thailand.
|
https://en.wikipedia.org/wiki?curid=14853910
|
2,244,484 |
Detailed result lists can be found on the "World Junior Athletics History" website. An unofficial count yields the number of about 189 athletes from about 9 countries: Argentina (42), Brazil (50), Chile (37), Colombia (12), Ecuador (1), Paraguay (6), Peru (2), Uruguay (10), Venezuela
|
https://en.wikipedia.org/wiki?curid=33608225
|
2,244,485 |
One of the substrates, (R)-1-aminopropan-2-yl phosphate, is produced by CobD (). This enzyme is part of the biosynthetic pathway to cobalamin (vitamin B) in bacteria.
|
https://en.wikipedia.org/wiki?curid=39608798
|
2,244,486 |
The regatta was held on Lake Lucerne; the 1908 European Rowing Championships had also been held there. From 1933 onwards, the nearby Rotsee was used for regattas instead. The final race day in 1926 was Monday, 6 September. The Italian eight was from Canottieri Bucintoro in Venice.
|
https://en.wikipedia.org/wiki?curid=56866213
|
2,244,487 |
"H. aucheri" was first described in "Ill. Pl. Orient." by Hippolyte Jaubert and Spach in 1842. It is closely related to "Hypericum thasium", but is smaller in all parts. Several variants were described by Jordanov & Kožukharov in 1970, but none of them seem to warrant taxonomic differentiation and are considered to be synonyms. However, a variant of the species found in the Kazdağ Mountains of Turkey called "Hypericum kazdaghense" may have enough distinctions from "H. aucheri" to warrant taxonomic consideration. These differences include amber instead of black anther glands, dichasial inflorescence, and different stem patterns.
|
https://en.wikipedia.org/wiki?curid=59957991
|
2,244,488 |
In 2015 IFU linked with the Institut d'Urbanisme de Paris at Paris 12 Val de Marne University to form the Ecole d'urbanisme de Paris.
|
https://en.wikipedia.org/wiki?curid=43840431
|
2,244,489 |
Kathrin Altwegg was born on 11 December 1951 in Balsthal. Between 1957 and 1970, she completed her primary education in Balsthal and passed the High school diploma in Switzerland at the lycée in Solothurn.
|
https://en.wikipedia.org/wiki?curid=67267891
|
2,244,490 |
The larvae feed on the leaves of "Monarda" species, including "Monarda fistulosa". They create an annulate case.
|
https://en.wikipedia.org/wiki?curid=31752758
|
2,244,491 |
One formerly recognised variety, namely "Aster radula" var. "strictus" , is present in the northern part of its range including Newfoundland and Labrador, northern Quebec and northern Nova Scotia. It differs in being more slender and having only 1 to 8 heads, which is probably a response to the harsh climate. However, it is not commonly recognised due to the range of intermediates that exist from north to south and currently no combination (i.e. with var. "strictus") currently exists in "Eurybia".
|
https://en.wikipedia.org/wiki?curid=12169137
|
2,244,492 |
Murray, described as a "Eurasian" was born in 1841 in Tanna, (he claimed later to be a resident of Perth, Scotland) in the state of Maharashtra, India and resided in Byculla, Bombay. He was briefly a Member of the Bombay Natural History Society and Anthropological Society of Bombay, a manager at the Victoria Natural History Institute (around 1886-88, Murray also produced a periodical called "Indian Annals and Magazine of Natural Science" (from 1886) and branches of the Victoria Natural History Institute were begun in Mysore and Bangalore around 1892 and a report of the Bangalore Museum reported that they were hoping for good taxidermy services at a reasonable price from the organization) and curator at the Kurrachee Municipal Library and Museum. While at Karachi he had sold off duplicate volumes from the library for which he was tried and acquitted. He then moved to Bombay in 1887 to establish a private natural history concern hoping to prepare and stuff specimens for sale. He advertised the society with the appearance of being associated with the British Museum and with connections to several governments and wealthy patrons. He had obtained sums of nearly 1500 to 2000 rupees from nearly seventy persons, offering them positions in branches across the country. He paid salaries of Rs 50 or 60 for a few months and no complaints were made for a period. He then found himself unable to maintain an office and a case of swindling was registered against him. In April 1893, he was charged with cheating two Indians, Narain Abba Subia and C. Ruggonath Chetty of Rs 1500 each and sentenced to five years of rigorous imprisonment by Justice L.H. Bayley. Witnesses in the case included H.M. Phipson who noted that he had given personal loans to Murray and had had his name removed from the list of subscribers of the Bombay Natural History Society for failure to pay subscription fees.
|
https://en.wikipedia.org/wiki?curid=4924563
|
2,244,493 |
He published German translations of Joseph Priestley's experiments and observations on the different kinds of air, ""Versuche und Beobachtungen über verschiedene Gattungen der Luft"" and of John Elliot's physiological observations involving the senses, ""Physiologische Beobachtungen über die Sinne"". Other noted works by Ludwig are:
|
https://en.wikipedia.org/wiki?curid=48556364
|
2,244,494 |
The codex contains a part of the Gospel of Mark (3:2-3; 4:4-5), on only 1 parchment leaf (33 cm by 23 cm). The text is written in two columns per page, 23 lines per page.
|
https://en.wikipedia.org/wiki?curid=20292150
|
2,244,495 |
Agen in the early 17th century was at the crossroads of the religious debate revolving around the new Protestant faith. The region favoured the Reformation. Nerac its neighbour and rival was the political and intellectual capital of French Protestants. The Edict of Nerac in 1579 had given the French Protestant 14 more protected towns and confirmed the Edict of Poitiers that recognised the religious rights of Protestants in France. Josephus Justus had been seduced by the Reformation and become one of its great scholars. Yet Joseph Barsalou's life took a different direction from his predecessor. Joseph Barsalou gravitated towards Avignon and Rome the centers of Roman Catholic Church.
|
https://en.wikipedia.org/wiki?curid=20755981
|
2,244,496 |
It is an annual herb growing erect to maximum heights anywhere between 5 centimeters and half a meter. The leaves are up to 17 centimeters long in the basal rosette, divided into lobes and sometimes toothed, and smaller farther up on the plant.
|
https://en.wikipedia.org/wiki?curid=24458430
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2,244,497 |
"Darwinia polychroma" is a spreading shrub up to high and wide when mature, with many old, grey, leafless woody stems on the ground, but is an erect shrub when young. The leaves are densely crowded on the ends of branches, and are linear, triangular in cross-section, long and wide on a petiole about long. The flowers are arranged in drooping groups surrounded by several overlapping rows of yellowish green, green and red bracts long. Each flower has two boat-shaped to egg-shaped bracteoles at the base. The floral tube is yellowish green, about long, the sepal lobes about long, the petals long and there are 10 stamens and 10 staminodes. Flowering mainly occurs from July to September.
|
https://en.wikipedia.org/wiki?curid=53109229
|
2,244,498 |
The 3 substrates of this enzyme are ATP, HO, and beta-glucan, whereas its 3 products are ADP, phosphate, and beta-glucan.
|
https://en.wikipedia.org/wiki?curid=14337256
|
2,244,499 |
This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is malate:CoA ligase (ADP-forming). Other names in common use include malyl-CoA synthetase, malyl coenzyme A synthetase, and malate thiokinase. This enzyme participates in glyoxylate and dicarboxylate metabolism.
|
https://en.wikipedia.org/wiki?curid=14286121
|
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