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PMC11279060_p25
|
PMC11279060
|
sec[2]/p[1]
|
3. Discussion
| 4.367188 |
biomedical
|
Study
|
[
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MreB has been shown to play a central role in the control of rod-shaped growth in many bacterial species . Much is known on its connection with the cell wall synthesis machinery, and with enzymes providing the precursors for cell wall extension, but the exact way in which the rotation of MreB filaments affects the rate of cell wall synthesis is still unclear. It has been shown that the directional motion of MreB filaments and the reversal of the direction correlates with the motion of PG synthesizing enzymes, and that filament dynamics correlate with growth speed . Together with many previous observations, these data suggest that in B. subtilis , MreB filaments may play a crucial role in directing the speed of cell wall elongation and in coordinating all the enzymes involved in PG extension during unperturbed growth.
|
[
"Simon Dersch",
"Peter L. Graumann"
] |
https://doi.org/10.3390/microorganisms12071309
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999995 |
PMC11279060_p26
|
PMC11279060
|
sec[2]/p[2]
|
3. Discussion
| 4.546875 |
biomedical
|
Study
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We have recently begun to uncover that MreB may have additional roles in the physiology of bacterial cells that are important when growth conditions become suboptimal for cell proliferation. We have found that osmotic upshift leads to the disassembly of about 50% of fMreB, which is accompanied by a transient loss of the regular cell shape during the adaptation phase . A total of 2 h after the application of osmotic stress, cell wall synthesis regained its regular pattern and MreB filaments returned to their normal appearance. We propose that the transient loss of MreB filament formation slows down cell wall growth, allowing cells to adopt to new osmotic conditions. While this hypothesis still needs proof, we have addressed the question why MreB filaments might disassemble during osmotic stress conditions. We tested two hypotheses: (a) MreB filaments disassemble because a major interactor and modulator of MreB filaments, RodZ, might respond to osmotic upshift conditions, or (b) MreB filaments might be affected by changes in osmolarity per se. In this respect, there is an intriguing parallel: as a first response to an increase in extracellular osmolarity, B. subtilis cells allow potassium ions to enter the cytosol as a first means to counterbalance the influx of water into cells . Because potassium ions per se are problematic for cells, this first wave of influx is reversed and compensated for by the production and import of compatible solutes, such as glycine betaine or proline or trehalose . Interestingly, the assembly of MreB filaments is negatively affected by monovalent kations, and thus greatly by potassium . To test hypothesis A), we investigated if MreB filaments disassemble in the absence of RodZ in response to osmotic upshift, which was the case, ruling out a direct role of RodZ in this process. Interestingly, RodZ motion was strongly affected by osmotic stress: the protein shifted from 47% molecules being bound to a larger complex (i.e., MreB filaments) to 34%, showing that, like MreB, RodZ became more freely diffusive. It is very likely that RodZ becomes more diffusive because MreB filaments disintegrate during osmotic upshift, leading to the loss of a major interaction target for RodZ.
|
[
"Simon Dersch",
"Peter L. Graumann"
] |
https://doi.org/10.3390/microorganisms12071309
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999996 |
PMC11279060_p27
|
PMC11279060
|
sec[2]/p[3]
|
3. Discussion
| 4.398438 |
biomedical
|
Study
|
[
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To test if potassium influx might affect fMreB, we tested deletions of two major potassium importers, KtrAB and KtrCD, that play a key role in the osmotic stress response in B. subtilis . We observed no effect on single molecule dynamics of MreB, i.e., no disassembly occurred in cells lacking strong potassium influx. Because MreB filament disassembly was seen when a minor potassium channel (KimA) was deleted, our data show that strong potassium influx is triggering filament disintegration. Thus, changes in MreB single molecule dynamics depend on potassium influx, which in turn is essential for adaptation to increased osmolarity: ktrAB or ktrCD deletion strains show strong defects in growth after osmotic upshift . This could be due to an increase in protein aggregation because of water loss following osmotic upshift. However, we propose that MreB could play an active role in stress adaptation: we observed that the pattern of cell wall synthesis becomes spotty as opposed to relatively uniform along the lateral cell wall, which is not the case (or less pronounced) in ktrB or ktrD mutant cells. This indicates that during osmotic adaptation, cell wall synthesis becomes less uniform and thus possibly less effective, allowing cells to adapt to new osmotic conditions in the environment by slowed-down synthesis. Indeed, cell wall synthesis enzymes have been shown to be differently active at different pH conditions , or, for example, inhibited at high magnesium concentrations (autolysins) , such that the cell wall synthesis machinery has the capacity to operate at different environmental conditions , However, with the need to adapt after a shift from optimal growth conditions.
|
[
"Simon Dersch",
"Peter L. Graumann"
] |
https://doi.org/10.3390/microorganisms12071309
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999996 |
PMC11279060_p28
|
PMC11279060
|
sec[2]/p[4]
|
3. Discussion
| 4.371094 |
biomedical
|
Study
|
[
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[
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We also investigated if mutations in MreB that affect ATPase activity, or lead to the weakening of subunit contacts, change the dynamics of MreB at a single molecule level. Reduced ATPase activity led to a severe loss of filament formation, as did—to a lesser but considerable extent—the interface mutations. However, interestingly, both mutant forms showed aberrant changes to osmotic upshift: the addition of 1M sorbitol as non-ionic osmotic stress further disassembled MreB D158A (ATPase mutant) filaments, or had no effect on MreB A277Q/K305D (interface mutant), while sodium chloride upshift led to a strong increase in filament formation for both mutant versions. Thus, the effect of potassium influx on MreB filaments depends on proper filament architecture, i.e., the biochemical properties of fMreB. These findings further support the idea that MreB filaments show a specific response to changes in intracellular ion concentrations, helping cells to adapt to new stress conditions. The latter hypothesis is difficult to test: mreB mutant cells grow poorly, even in the presence of increased magnesium concentrations, which may be based on the pleiotrophic effects caused by the absence of MreB.
|
[
"Simon Dersch",
"Peter L. Graumann"
] |
https://doi.org/10.3390/microorganisms12071309
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999997 |
PMC11279060_p29
|
PMC11279060
|
sec[2]/p[5]
|
3. Discussion
| 4.277344 |
biomedical
|
Study
|
[
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Thus, our work uncovers that the changes in MreB filaments occurring to osmotic upshift depend on potassium influx, are affected by mutations changing filament architecture, and are paralleled by changes in the pattern of PG synthesis. These observations extend the repertoire of MreB filament dynamics and point to a possible role of MreB during adaptations to changes in the environment, in addition to a putative scaffolding role during cell wall extension under non-perturbed growth conditions.
|
[
"Simon Dersch",
"Peter L. Graumann"
] |
https://doi.org/10.3390/microorganisms12071309
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999999 |
PMC11279060_p30
|
PMC11279060
|
sec[3]/sec[0]/p[0]
|
4.1. Growth Conditions
| 4.140625 |
biomedical
|
Study
|
[
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Cells were inoculated from overnight culture in S7 50 minimal media (fructose as carbon source) with the respectively appropriate antibiotics (100 mg/mL ampicillin, 100 mg/mL spectinomycin, 5 mg/mL chloramphenicol) at 30 °C shaking (200 rpm), and grown to the exponential phase (OD ~0.6). The expression of genes under the control of the p xyl -promotor was induced by the addition of xylose to a final concentration of 0.01%. To induce osmotic stress, NaCl or sorbitol were added to a final concentration of 0.5 M or 1 M, respectively, and, if not stated otherwise, cells were imaged 30 min after induction. If not stated otherwise, 4 µL of exponentially growing cell culture (OD ~0.6) were spotted on glass coverslips (Roth) and fixed with a S7 50 agarose pad (1% v / w ), mounted on the microscope and subsequently imaged.
|
[
"Simon Dersch",
"Peter L. Graumann"
] |
https://doi.org/10.3390/microorganisms12071309
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999999 |
PMC11279060_p31
|
PMC11279060
|
sec[3]/sec[1]/p[0]
|
4.2. Construction of Strains
| 4.230469 |
biomedical
|
Study
|
[
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The YFP-MreB fusion was taken from , and likewise both mutant mreB alleles. The YFP-RodZ construct was generated by a single crossover integration of pHJDS into which the first 500 bp of rodZ had been cloned using Eco RI/ Apa I restriction sites. The generated plasmid was integrated into the B. subtilis chromosome by single crossover integration. This generated a construct, in which the transcription of yfp-rodZ is driven by the pxyl promoter, and the original promoter drives the expression of an N-terminally truncated rodZ gene. The integrity of the strain was verified by (a) the sequencing of a PCR fragment generated by primers binding within pxyl (driving the expression of yfp-rodZ ) downstream of the 500 inserted rodZ bases (ensuring proper genome integration), and by Western blotting, showing a band at 52 kDa (ensuring that full length YFP-RodZ is produced). Mutant strains ( rodZ , ktrB , ktrD , ΔkimA ) were generated by transforming respective deletion strains ( B. subtilis mutant collection) with chromosomal DNA from the strain expressing YFP-MreB from the amyE site (see above).
|
[
"Simon Dersch",
"Peter L. Graumann"
] |
https://doi.org/10.3390/microorganisms12071309
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999995 |
PMC11279060_p32
|
PMC11279060
|
sec[3]/sec[2]/p[0]
|
4.3. Microscopy and Image Analysis
| 4.203125 |
biomedical
|
Study
|
[
0.99951171875,
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[
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Slim field microscopy was performed on a customized Nikon Eclipse Ti microscope setup, (100x oil-immersion objective, NA = 1.49) where the laser was aligned to the back focal plane of the object. Fluorescent protein fusions were illuminated using a 514 nm laser diode beam line of 100 mW power (160 W cm −2 on image plane) to first bleach most of the fluorophores, and subsequently track single molecules (events with a single bleaching step). A high-refresh EMCCD camera (ImagEM X2 EM-CCD, Hamamatsu) and frame transfer mode was used to acquire 20 ms stream acquisitions over 30 s per movie. Epifluorescence microscopy was performed using a Zeiss Axio Observer Z1 (100x oil-immersion, 1.46 NA, Photometrics Cascade II:512 camera). Gated-STED microscopy was performed using a Leica SP8 confocal microscope with a CW laser (200 hz, 4-line averages, unidirectional scanning).
|
[
"Simon Dersch",
"Peter L. Graumann"
] |
https://doi.org/10.3390/microorganisms12071309
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999997 |
PMC11279060_p33
|
PMC11279060
|
sec[3]/sec[2]/p[1]
|
4.3. Microscopy and Image Analysis
| 4.117188 |
biomedical
|
Study
|
[
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[
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] |
For this study we chose the Gaussian mixture model (GMM) as the basis for analysis, which was also used in our initial publication on the motion of MreB and cell wall synthesis enzymes. GMM can explain a given set of single molecule displacement data by fitting the most likely superposition of, in our case, up to three Gaussian curves, as molecules might exhibit multiple diffusive sub-populations, depending on their state (for example DNA-bound state vs. freely diffusive state). Using GMM we can infer the distinct fraction sizes and diffusion constants of the respective populations of a given molecule from the probability density of displacements.
|
[
"Simon Dersch",
"Peter L. Graumann"
] |
https://doi.org/10.3390/microorganisms12071309
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999995 |
PMC11279060_p34
|
PMC11279060
|
sec[3]/sec[2]/p[2]
|
4.3. Microscopy and Image Analysis
| 4.085938 |
biomedical
|
Study
|
[
0.9990234375,
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[
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] |
SMTracker allows for a simultaneous fit, where the subpopulation diffusion constants Dx over different states are identical, and changes are reflected in the variation in fraction sizes αx . In this case, the simultaneously set subpopulation diffusion constants Dx are determined by the best fit over all compared conditions. This allows us to directly compare the changes in a molecule’s movement profile over different treatments or conditions via percentile changes in the distinct sub-populations fraction sizes.
|
[
"Simon Dersch",
"Peter L. Graumann"
] |
https://doi.org/10.3390/microorganisms12071309
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999997 |
PMC11279060_p35
|
PMC11279060
|
sec[3]/sec[2]/p[3]
|
4.3. Microscopy and Image Analysis
| 2.929688 |
biomedical
|
Study
|
[
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[
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] |
The goodness of the Gaussian fits was determined by comparing the observed with the predicted data spreads, and for all tested conditions the R 2 was at least 0.98, indicating that the data quality was sufficient.
|
[
"Simon Dersch",
"Peter L. Graumann"
] |
https://doi.org/10.3390/microorganisms12071309
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999998 |
PMC11279060_p36
|
PMC11279060
|
sec[3]/sec[2]/p[4]
|
4.3. Microscopy and Image Analysis
| 4.058594 |
biomedical
|
Study
|
[
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[
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Demographs were generated with Oufti from n = 100 cells each. Demographs of n = 100 cells, where each cell is represented by a one pixel wide line of its integrated fluorescence signal. The cells are identified by polygonal cell meshes in Oufti, sorted by length and segmented. The fluorescence signal for each corresponding segment is normalized by the fluorescence of the brightest segment of each cell. The segments are then plotted as a one-pixel wide heat map from 0 (no signal) to 1 (maximum-signal).
|
[
"Simon Dersch",
"Peter L. Graumann"
] |
https://doi.org/10.3390/microorganisms12071309
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999997 |
PMC11279060_p37
|
PMC11279060
|
sec[3]/sec[3]/p[0]
|
4.4. Fluorescent D-Amino Acid (FDAA) Labeling
| 3.970703 |
biomedical
|
Study
|
[
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[
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FDAA-labeling to visualize cell wall synthesis was performed utilizing HADA, according to . HADA was added to a final concentration of 0.5 mM, followed by incubation for 20 min, shaking (30 °C, 200 rpm, tubes were wrapped in aluminum foil to block out light), and subsequent washing three times with PBS, immediately before mounting and imaging.
|
[
"Simon Dersch",
"Peter L. Graumann"
] |
https://doi.org/10.3390/microorganisms12071309
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999997 |
PMC11279072_p0
|
PMC11279072
|
sec[0]/p[0]
|
Introduction and background
| 3.78125 |
biomedical
|
Review
|
[
0.98828125,
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[
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By enabling procedures to be performed through tiny incisions using a camera and specialist instruments, laparoscopic surgery, sometimes known as minimally invasive surgery, completely changed the field of surgery. Comparing laparoscopic procedures to conventional open surgery, which was first established in the late 20th century, laparoscopic procedures have considerably decreased postoperative discomfort, hospital stays, and recovery times . Continuous technological developments, such as high-definition cameras, better instrumentation, and robotic-assisted systems, have enlarged the range and complexity of operations that may be performed laparoscopically and characterized the development of laparoscopic surgery .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999996 |
PMC11279072_p1
|
PMC11279072
|
sec[0]/p[1]
|
Introduction and background
| 3.833984 |
biomedical
|
Other
|
[
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[
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Combining minimally invasive methods with the concepts of conventional open surgery, hybrid laparoscopic techniques seek to maximize the advantages of each. To handle complicated surgical problems that may be challenging with laparoscopy alone, these techniques frequently combine laparoscopic operations with other modalities, such as endoscopic or robotic approaches . The value of hybrid approaches is found in their capacity to improve patient outcomes in complicated situations requiring a multidisciplinary approach, decrease invasiveness, and increase surgical precision .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999997 |
PMC11279072_p2
|
PMC11279072
|
sec[0]/p[2]
|
Introduction and background
| 4.058594 |
biomedical
|
Review
|
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[
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This review primarily aims to investigate the use and effectiveness of hybrid laparoscopic methods in handling challenging interdisciplinary cases, specifically focusing on the integration of traditional laparoscopic techniques with advanced modalities such as robotic and endoscopic technologies. Through an analysis of various surgical specialties, we aim to provide a comprehensive understanding of how these combined approaches can be applied to maximize patient care. This review will detail the technical specifics of integrating basic laparoscopic techniques with advanced technologies such as robotics and endoscopy, highlight particular examples where such hybrid approaches have been successfully implemented, and assess the outcomes achieved.
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999998 |
PMC11279072_p3
|
PMC11279072
|
sec[0]/p[3]
|
Introduction and background
| 3.873047 |
biomedical
|
Review
|
[
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[
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A paradigm change in contemporary surgery, hybrid laparoscopic procedures provide creative answers to complex surgical issues. Surgical outcomes, operational timelines, and recovery rates may all be improved by combining the advantages of several surgical modalities. Knowing and using hybrid techniques can have a big impact on surgical practice by encouraging more effective and efficient patient care as healthcare systems give minimally invasive procedures more and more priority. This review attempts to emphasize the value of these methods and promote their wider use in the surgical community.
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999997 |
PMC11279072_p4
|
PMC11279072
|
sec[1]/p[0]
|
Review
| 1.960938 |
biomedical
|
Other
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Hybrid laparoscopic techniques: an overview
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.857095 |
PMC11279072_p5
|
PMC11279072
|
sec[1]/p[1]
|
Review
| 1.166992 |
biomedical
|
Other
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[
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Definition
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.571427 |
PMC11279072_p6
|
PMC11279072
|
sec[1]/p[2]
|
Review
| 3.820313 |
biomedical
|
Other
|
[
0.98583984375,
0.01107025146484375,
0.003162384033203125
] |
[
0.00887298583984375,
0.8583984375,
0.1298828125,
0.00275421142578125
] |
Minimally invasive laparoscopic procedures and conventional open surgery are creatively combined in hybrid laparoscopic techniques. Using components of several surgical modalities, including robotic and endoscopic approaches, these procedures tackle difficult surgical problems that may not be possible with laparoscopic approaches alone. Using the advantages of minimally invasive techniques, such as less pain after surgery, shorter hospital stays, and faster recovery times, while preserving the adaptability and all-encompassing access of open surgery is the fundamental rationale behind hybrid laparoscopic surgery. Combining several surgical techniques in a sequence or simultaneously can improve the efficacy and safety of the operation .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999999 |
PMC11279072_p7
|
PMC11279072
|
sec[1]/p[3]
|
Review
| 1.748047 |
biomedical
|
Other
|
[
0.97314453125,
0.0105743408203125,
0.0160369873046875
] |
[
0.00749969482421875,
0.984375,
0.005626678466796875,
0.00263214111328125
] |
Scope and Applications in Various Surgical Disciplines
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999996 |
PMC11279072_p8
|
PMC11279072
|
sec[1]/p[4]
|
Review
| 2.791016 |
biomedical
|
Other
|
[
0.98974609375,
0.00786590576171875,
0.002346038818359375
] |
[
0.0044708251953125,
0.9794921875,
0.0140380859375,
0.0018911361694335938
] |
Hybrid laparoscopic procedures, combining basic laparoscopic techniques with advanced modalities such as robotic and endoscopic systems, are highly flexible and adaptable, making them invaluable across several surgical specialties. These methods prove particularly effective when single-modality approaches are insufficient to address complex surgical challenges. Key applications in various surgical specialties are discussed below.
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999996 |
PMC11279072_p9
|
PMC11279072
|
sec[1]/p[5]
|
Review
| 4.023438 |
biomedical
|
Review
|
[
0.99169921875,
0.00637054443359375,
0.0017261505126953125
] |
[
0.0214080810546875,
0.01361083984375,
0.9638671875,
0.0011548995971679688
] |
Gastrointestinal surgery: In the realm of complex gastrointestinal procedures such as colectomies (colonic resections) and proctectomies (rectal resections), as well as gastrectomies and esophagectomies, hybrid laparoscopic-endoscopic techniques are frequently employed. These advanced hybrid methods enable surgeons to perform intricate dissections, navigate challenging anatomical regions, and ensure complete oncological clearance with greater precision. The integration of laparoscopic and endoscopic approaches has demonstrated advantages over traditional methods, including shorter operative times, reduced complication rates, and faster recovery. Specifically, in the context of colorectal cancer, studies have documented improved oncological outcomes and decreased postoperative morbidity when these hybrid techniques are utilized .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999997 |
PMC11279072_p10
|
PMC11279072
|
sec[1]/p[6]
|
Review
| 4.054688 |
biomedical
|
Review
|
[
0.99169921875,
0.00681304931640625,
0.0017061233520507812
] |
[
0.0197296142578125,
0.05670166015625,
0.92138671875,
0.0020961761474609375
] |
Cardiothoracic surgery: Hybrid treatments for cardiothoracic conditions such as lung resections, mediastinal tumors, and complex coronary artery bypass grafting (CABG) combine open surgical techniques with minimally invasive thoracoscopic procedures. This integration enhances both surgical precision and patient outcomes. Research indicates that hybrid lung resections result in shorter hospital stays, reduced postoperative pain, and faster recovery compared to open thoracotomies. Hybrid CABG has been associated with improved cardiac function and reduced complication rates, offering a viable alternative for high-risk patients .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999995 |
PMC11279072_p11
|
PMC11279072
|
sec[1]/p[7]
|
Review
| 3.71875 |
biomedical
|
Other
|
[
0.98876953125,
0.00989532470703125,
0.0012350082397460938
] |
[
0.009246826171875,
0.94140625,
0.045501708984375,
0.003635406494140625
] |
Urological surgery: Hybrid laparoscopic techniques are employed in urological procedures such as nephrectomies, prostatectomies, and cystectomies. These techniques enhance surgical precision and reduce invasiveness, leading to better patient outcomes. Robotic-assisted laparoscopic prostatectomy, for instance, combines the advantages of laparoscopy with the dexterity and visualization provided by robotic systems, enabling precise dissection and nerve-sparing techniques .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999997 |
PMC11279072_p12
|
PMC11279072
|
sec[1]/p[8]
|
Review
| 3.775391 |
biomedical
|
Other
|
[
0.9931640625,
0.005950927734375,
0.0010137557983398438
] |
[
0.022003173828125,
0.77880859375,
0.1951904296875,
0.004207611083984375
] |
Gynecological surgery: Hybrid techniques have significantly advanced gynecological surgery, including hysterectomies, myomectomies, and endometriosis excisions. These methods often combine endoscopic guidance or robotic assistance with laparoscopic surgery, enhancing accuracy and reducing invasiveness. Robotic-assisted laparoscopic hysterectomies allow for precise dissection and suturing, reducing blood loss and postoperative pain compared to traditional methods .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999994 |
PMC11279072_p13
|
PMC11279072
|
sec[1]/p[9]
|
Review
| 3.759766 |
biomedical
|
Other
|
[
0.9912109375,
0.007320404052734375,
0.0014553070068359375
] |
[
0.01305389404296875,
0.81640625,
0.1671142578125,
0.0036487579345703125
] |
Orthopedic surgery: Although less common, hybrid laparoscopic methods are gaining traction in orthopedic surgery, particularly for joint replacements and spinal disorders. Combining open and minimally invasive techniques improves surgical outcomes and shortens recovery times. In spinal surgery, for example, hybrid approaches utilizing robotic guidance enhance the accuracy of vertebral fusion, while in hip replacements, laparoscopic guidance combined with robotic assistance allows for precise implant placement .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999997 |
PMC11279072_p14
|
PMC11279072
|
sec[1]/p[10]
|
Review
| 2.355469 |
biomedical
|
Other
|
[
0.98388671875,
0.010345458984375,
0.0057373046875
] |
[
0.0016727447509765625,
0.99267578125,
0.004413604736328125,
0.0014772415161132812
] |
The broad application of hybrid laparoscopic techniques underscores their potential to revolutionize surgical procedures across multiple disciplines. These methods represent a significant advancement in surgery by making procedures more precise, less invasive, and more effective.
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999993 |
PMC11279072_p15
|
PMC11279072
|
sec[1]/p[11]
|
Review
| 0.816895 |
other
|
Other
|
[
0.07916259765625,
0.002529144287109375,
0.91845703125
] |
[
0.01198577880859375,
0.9794921875,
0.0068359375,
0.001800537109375
] |
Historical Development
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999995 |
PMC11279072_p16
|
PMC11279072
|
sec[1]/p[12]
|
Review
| 3.904297 |
biomedical
|
Review
|
[
0.99169921875,
0.006107330322265625,
0.00229644775390625
] |
[
0.0201873779296875,
0.219970703125,
0.755859375,
0.0037994384765625
] |
Although laparoscopic surgery started in the early 1900s, it did not become widely accepted and popular until the 1980s and 1990s. The development of laparoscopic cholecystectomy in the late 1980s signaled a turning point by proving the viability and advantages of minimally invasive surgery. This achievement sparked interest and innovation in laparoscopic procedures across many surgical specialties. As the field evolved, surgeons encountered increasingly difficult cases that presented challenges for traditional laparoscopic techniques, such as limited access to some anatomical areas, issues with complex dissections, and the need for increased accuracy. Hybrid laparoscopic techniques were developed to overcome these limitations by combining the benefits of laparoscopic procedures with conventional open surgery .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999997 |
PMC11279072_p17
|
PMC11279072
|
sec[1]/p[13]
|
Review
| 3.384766 |
biomedical
|
Other
|
[
0.98486328125,
0.01129150390625,
0.0037441253662109375
] |
[
0.005931854248046875,
0.81591796875,
0.17333984375,
0.004711151123046875
] |
Early innovations: The minimally invasive surgical era began in 1987 when Dr. Erich Mühe performed the first laparoscopic cholecystectomy. Compared to open surgery, this technique demonstrated the potential for less postoperative pain, shorter hospital stays, and quicker recovery. Beyond cholecystectomy, laparoscopic techniques quickly expanded to include gynecology, urology, and general surgery treatments in the 1990s. Surgeons using laparoscopic techniques for gynecological procedures, hernia repairs, and appendectomies laid the foundation for increasingly complex applications .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999997 |
PMC11279072_p18
|
PMC11279072
|
sec[1]/p[14]
|
Review
| 4.019531 |
biomedical
|
Review
|
[
0.98876953125,
0.008544921875,
0.0024852752685546875
] |
[
0.01739501953125,
0.148681640625,
0.830078125,
0.0040283203125
] |
The emergence of hybrid techniques: Early in the new millennium, hybrid laparoscopic procedures emerged out of the necessity to enhance surgical outcomes in challenging patients. These methods combined or sequentially used laparoscopic instruments with additional modalities, including robotics, endoscopy, and advanced imaging technology, to increase surgical accuracy and efficacy . The invention of robotically assisted surgical systems, notably the da Vinci Surgical System, in the early 2000s revolutionized minimally invasive surgery. With the enhanced dexterity, precision, and visualization these technologies offered, complex procedures that were challenging with traditional laparoscopy became more manageable. The combination of laparoscopy with endoscopic and robotic techniques facilitated more thorough and precise procedures in complex patients .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999996 |
PMC11279072_p19
|
PMC11279072
|
sec[1]/p[15]
|
Review
| 3.964844 |
biomedical
|
Review
|
[
0.99462890625,
0.00370025634765625,
0.0017652511596679688
] |
[
0.054534912109375,
0.20166015625,
0.7412109375,
0.0024204254150390625
] |
Technological advancements: Throughout the 2010s, technological advancements further propelled hybrid laparoscopic procedures. The introduction of advanced imaging technologies, such as 3D imaging and fluorescence-guided surgery, significantly enhanced the capabilities of hybrid techniques. These innovations improved intraoperative visualization and precision, enabling better surgical outcomes in challenging multidisciplinary cases. The latest development in this field is the integration of augmented reality (AR) and artificial intelligence (AI) in hybrid laparoscopic procedures. AR provides real-time, enhanced visualization of anatomical structures, while AI-driven systems assist with surgical planning and intraoperative decision-making, further pushing the boundaries of what can be achieved with hybrid techniques .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999997 |
PMC11279072_p20
|
PMC11279072
|
sec[1]/p[16]
|
Review
| 3.677734 |
biomedical
|
Other
|
[
0.986328125,
0.01094818115234375,
0.002902984619140625
] |
[
0.006893157958984375,
0.798828125,
0.190673828125,
0.0033817291259765625
] |
The evolution of laparoscopic methods into hybrid techniques over time reflects the continuous pursuit of innovation and improvement in surgical practice. By combining multiple modalities and leveraging technological advancements, hybrid laparoscopic procedures have revolutionized surgery and opened new avenues for managing complex multidisciplinary patients. This ongoing evolution underscores the commitment to enhancing surgical precision, reducing invasiveness, and improving patient outcomes across various medical disciplines.
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999994 |
PMC11279072_p21
|
PMC11279072
|
sec[1]/p[17]
|
Review
| 1.805664 |
biomedical
|
Other
|
[
0.84765625,
0.0667724609375,
0.0853271484375
] |
[
0.007633209228515625,
0.986328125,
0.002361297607421875,
0.003536224365234375
] |
Applications in complex multidisciplinary cases
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999997 |
PMC11279072_p22
|
PMC11279072
|
sec[1]/p[18]
|
Review
| 1.526367 |
biomedical
|
Other
|
[
0.9560546875,
0.0202178955078125,
0.023681640625
] |
[
0.0304412841796875,
0.95751953125,
0.007610321044921875,
0.00428009033203125
] |
Gastrointestinal Surgery
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999994 |
PMC11279072_p23
|
PMC11279072
|
sec[1]/p[19]
|
Review
| 3.972656 |
biomedical
|
Other
|
[
0.99072265625,
0.007518768310546875,
0.0016880035400390625
] |
[
0.02691650390625,
0.6337890625,
0.333984375,
0.0051116943359375
] |
Hybrid laparoscopic procedures have been essential in gastrointestinal surgery for managing complex cases that require meticulous and comprehensive treatments. These approaches often combine robotic or endoscopic support with laparoscopic techniques to enhance surgical outcomes. For instance, in esophagectomy, hybrid techniques merge laparoscopic dissection with endoscopic mucosal resection to ensure the complete removal of esophageal tumors while preserving as much healthy tissue as possible. Similarly, in laparoscopic colorectal procedures, robotic assistance allows for greater dexterity and precision in performing anastomoses and complex dissections .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999997 |
PMC11279072_p24
|
PMC11279072
|
sec[1]/p[20]
|
Review
| 3.855469 |
biomedical
|
Review
|
[
0.99755859375,
0.0016565322875976562,
0.0009326934814453125
] |
[
0.054168701171875,
0.0030994415283203125,
0.94189453125,
0.0006575584411621094
] |
Case studies have demonstrated the effectiveness of hybrid approaches in gastrointestinal surgery. One notable example involves research on gastric cancer patients, where minimally invasive gastrectomies were performed using hybrid laparoscopic-endoscopic techniques. Compared to traditional open surgeries, these hybrid procedures resulted in shorter operative times, reduced complication rates, and faster recovery. Similarly, in colorectal cancer cases, hybrid strategies have been associated with improved oncological outcomes and lower postoperative morbidity .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999997 |
PMC11279072_p25
|
PMC11279072
|
sec[1]/p[21]
|
Review
| 3.710938 |
biomedical
|
Other
|
[
0.9921875,
0.006103515625,
0.0017995834350585938
] |
[
0.01238250732421875,
0.732421875,
0.252685546875,
0.002811431884765625
] |
The advantages of hybrid laparoscopic procedures in gastrointestinal surgery primarily include better patient outcomes, reduced invasiveness, and increased precision. These methods enable surgeons to perform intricate operations with greater accuracy, minimizing damage to surrounding tissues and shortening postoperative recovery and discomfort. Additionally, the integration of robotic assistance and advanced imaging technologies further enhances surgical precision and outcomes .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999999 |
PMC11279072_p26
|
PMC11279072
|
sec[1]/p[22]
|
Review
| 3.78125 |
biomedical
|
Other
|
[
0.98681640625,
0.0113677978515625,
0.0018033981323242188
] |
[
0.0129241943359375,
0.59228515625,
0.39013671875,
0.0045166015625
] |
However, hybrid approaches do present certain challenges. These include the need for specialized skills and training, longer operative times due to the complexity of the procedures, and higher costs associated with advanced technologies . Moreover, coordinating the use of multiple modalities in a single operation can be technically demanding and requires seamless collaboration among the surgical team . By addressing these challenges and capitalizing on the benefits, hybrid laparoscopic procedures in gastrointestinal surgery can continue to evolve and improve, offering significant advantages in the management of complex surgical cases.
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999996 |
PMC11279072_p27
|
PMC11279072
|
sec[1]/p[23]
|
Review
| 1.666992 |
biomedical
|
Other
|
[
0.94775390625,
0.0254669189453125,
0.027008056640625
] |
[
0.02154541015625,
0.96630859375,
0.00804901123046875,
0.003997802734375
] |
Cardiothoracic Surgery
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999996 |
PMC11279072_p28
|
PMC11279072
|
sec[1]/p[24]
|
Review
| 3.925781 |
biomedical
|
Other
|
[
0.99169921875,
0.006786346435546875,
0.0016183853149414062
] |
[
0.02056884765625,
0.67529296875,
0.299560546875,
0.004749298095703125
] |
Hybrid techniques are increasingly utilized in cardiothoracic surgery to address conditions such as coronary artery disease, mediastinal tumors, and lung resections. One notable hybrid approach for lung resections combines open surgical techniques with minimally invasive thoracoscopic surgery. This method reduces the invasiveness of the procedure while ensuring precise tumor removal. Another compelling example is hybrid CABG, which treats complex coronary artery disease by integrating conventional surgical bypass with percutaneous coronary intervention .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999996 |
PMC11279072_p29
|
PMC11279072
|
sec[1]/p[25]
|
Review
| 3.921875 |
biomedical
|
Review
|
[
0.9931640625,
0.005069732666015625,
0.0020008087158203125
] |
[
0.009552001953125,
0.00893402099609375,
0.98095703125,
0.0006594657897949219
] |
Hybrid techniques in cardiothoracic surgery have demonstrated promising results . For instance, studies comparing hybrid lung resections to traditional open thoracotomies have shown shorter hospital stays, reduced postoperative pain, and quicker recovery times. Additionally, hybrid CABG has emerged as a viable alternative for high-risk patients who may not be suitable candidates for traditional CABG alone, offering improved cardiac function and a lower risk of complications .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999997 |
PMC11279072_p30
|
PMC11279072
|
sec[1]/p[26]
|
Review
| 3.773438 |
biomedical
|
Review
|
[
0.9833984375,
0.01374053955078125,
0.0030689239501953125
] |
[
0.00620269775390625,
0.45751953125,
0.53173828125,
0.004619598388671875
] |
The adoption of hybrid techniques in cardiothoracic surgery underscores their potential to enhance surgical precision and patient outcomes. By combining the strengths of open and minimally invasive approaches, these techniques provide a balanced solution that minimizes invasiveness while maximizing effectiveness. The success of hybrid techniques in this field highlights their role in advancing surgical practices and improving patient care for complex cardiothoracic conditions.
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999997 |
PMC11279072_p31
|
PMC11279072
|
sec[1]/p[27]
|
Review
| 1.472656 |
biomedical
|
Other
|
[
0.94873046875,
0.013275146484375,
0.037841796875
] |
[
0.01383209228515625,
0.98046875,
0.0030670166015625,
0.0024356842041015625
] |
Urological Surgery
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999994 |
PMC11279072_p32
|
PMC11279072
|
sec[1]/p[28]
|
Review
| 3.876953 |
biomedical
|
Other
|
[
0.99462890625,
0.004421234130859375,
0.0009522438049316406
] |
[
0.051422119140625,
0.55859375,
0.38623046875,
0.003940582275390625
] |
Hybrid laparoscopic techniques are employed in various urological procedures, including cystectomies, prostatectomies, and nephrectomies. These methods frequently incorporate robotic assistance to enhance the accuracy and efficacy of laparoscopic operations. For example, in robotic-assisted laparoscopic prostatectomy, the advantages of laparoscopy are combined with the increased dexterity and visualization provided by robotic systems. This integration allows for precise dissection and nerve-sparing techniques, leading to improved postoperative outcomes .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999996 |
PMC11279072_p33
|
PMC11279072
|
sec[1]/p[29]
|
Review
| 3.873047 |
biomedical
|
Other
|
[
0.9873046875,
0.01088714599609375,
0.0017251968383789062
] |
[
0.01227569580078125,
0.91845703125,
0.06610107421875,
0.003040313720703125
] |
In cystectomies, hybrid techniques facilitate the removal of the bladder with a combination of laparoscopic and robotic approaches, offering better control and precision while minimizing invasiveness. Similarly, nephrectomies benefit from hybrid methods by enabling surgeons to perform complex kidney surgeries with greater accuracy and reduced risk of complications. The use of advanced imaging and robotic systems in these procedures enhances the surgeon’s ability to navigate intricate anatomical structures, ultimately improving patient outcomes .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999996 |
PMC11279072_p34
|
PMC11279072
|
sec[1]/p[30]
|
Review
| 3.792969 |
biomedical
|
Review
|
[
0.98046875,
0.016632080078125,
0.00305938720703125
] |
[
0.005931854248046875,
0.424072265625,
0.56396484375,
0.005886077880859375
] |
The incorporation of hybrid techniques in urological surgery underscores their significant potential in refining surgical practices. By leveraging the strengths of both laparoscopic and robotic modalities, these techniques provide a balanced approach that maximizes precision, reduces invasiveness, and enhances overall surgical effectiveness. The success of hybrid laparoscopic techniques in urology highlights their crucial role in advancing the field and improving patient care for complex urological conditions .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999996 |
PMC11279072_p35
|
PMC11279072
|
sec[1]/p[31]
|
Review
| 1.381836 |
biomedical
|
Other
|
[
0.93359375,
0.0185089111328125,
0.047821044921875
] |
[
0.0323486328125,
0.95556640625,
0.0084228515625,
0.0037994384765625
] |
Gynecological Surgery
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999996 |
PMC11279072_p36
|
PMC11279072
|
sec[1]/p[32]
|
Review
| 3.902344 |
biomedical
|
Review
|
[
0.99560546875,
0.0031452178955078125,
0.0010471343994140625
] |
[
0.037994384765625,
0.08978271484375,
0.8701171875,
0.001972198486328125
] |
Hybrid laparoscopic techniques have significantly transformed gynecological surgery, particularly in procedures such as hysterectomies, myomectomies, and endometriosis excisions. These methods often combine endoscopic guidance or robotic assistance with laparoscopic surgery to enhance accuracy and reduce invasiveness. For example, robotic-assisted laparoscopic hysterectomies allow for more precise dissection and suturing compared to conventional laparoscopic or open hysterectomies, resulting in lower blood loss and reduced postoperative pain .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999997 |
PMC11279072_p37
|
PMC11279072
|
sec[1]/p[33]
|
Review
| 3.816406 |
biomedical
|
Other
|
[
0.9873046875,
0.0106964111328125,
0.0017766952514648438
] |
[
0.00875091552734375,
0.9423828125,
0.04595947265625,
0.0028076171875
] |
In myomectomy, hybrid techniques enable the complete removal of fibroids while preserving the integrity of the uterus. This is achieved by combining laparoscopic removal of fibroids with robotic assistance, which enhances precision and control. Similarly, in endometriosis excisions, hybrid approaches allow for thorough treatment of the condition with minimal invasiveness, improving patient outcomes and reducing recovery times .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999997 |
PMC11279072_p38
|
PMC11279072
|
sec[1]/p[34]
|
Review
| 3.771484 |
biomedical
|
Review
|
[
0.98388671875,
0.01282501220703125,
0.00348663330078125
] |
[
0.005107879638671875,
0.382568359375,
0.60791015625,
0.004367828369140625
] |
The integration of hybrid laparoscopic techniques in gynecological surgery underscores their potential to revolutionize surgical practices. By leveraging the advantages of both laparoscopic and robotic modalities, these techniques offer a balanced approach that maximizes precision, minimizes invasiveness, and enhances overall surgical effectiveness. The success of hybrid techniques in gynecology highlights their crucial role in advancing the field and improving patient care for complex gynecological conditions .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999995 |
PMC11279072_p39
|
PMC11279072
|
sec[1]/p[35]
|
Review
| 0.994141 |
other
|
Other
|
[
0.176513671875,
0.0085906982421875,
0.81494140625
] |
[
0.00933074951171875,
0.98583984375,
0.0035228729248046875,
0.0015048980712890625
] |
Other Specialties
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999998 |
PMC11279072_p40
|
PMC11279072
|
sec[1]/p[36]
|
Review
| 3.789063 |
biomedical
|
Other
|
[
0.994140625,
0.004241943359375,
0.001468658447265625
] |
[
0.0195465087890625,
0.80615234375,
0.1717529296875,
0.0025501251220703125
] |
Hybrid laparoscopic techniques are also being applied in other surgical fields such as orthopedic and neurological surgery. In orthopedic surgery, these techniques are used for procedures such as spinal fusion, hip replacements, and knee arthroscopies. For instance, hybrid approaches in spinal surgery combine minimally invasive laparoscopic techniques with robotic guidance to enhance the accuracy of vertebral fusion and reduce recovery times. In hip replacements, hybrid techniques involving laparoscopic guidance and robotic assistance allow for precise implant placement and improved joint function .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999997 |
PMC11279072_p41
|
PMC11279072
|
sec[1]/p[37]
|
Review
| 3.888672 |
biomedical
|
Other
|
[
0.9970703125,
0.0022869110107421875,
0.0005083084106445312
] |
[
0.10382080078125,
0.81298828125,
0.08026123046875,
0.002948760986328125
] |
In neurological surgery, hybrid laparoscopic techniques are utilized for complex procedures such as brain tumor resections and spinal cord surgeries. These techniques often involve the use of advanced imaging technologies and robotic systems to improve surgical precision and minimize damage to surrounding neural tissues. For example, hybrid approaches in brain tumor surgery combine laparoscopic methods with intraoperative MRI guidance to ensure complete tumor removal while preserving critical brain functions .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999994 |
PMC11279072_p42
|
PMC11279072
|
sec[1]/p[38]
|
Review
| 2.185547 |
biomedical
|
Other
|
[
0.96630859375,
0.020477294921875,
0.01324462890625
] |
[
0.0097808837890625,
0.9443359375,
0.042755126953125,
0.0029659271240234375
] |
Advantages and challenges of hybrid laparoscopic techniques
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999995 |
PMC11279072_p43
|
PMC11279072
|
sec[1]/p[39]
|
Review
| 1.045898 |
other
|
Other
|
[
0.246337890625,
0.00853729248046875,
0.7451171875
] |
[
0.01499176025390625,
0.97802734375,
0.005176544189453125,
0.0019664764404296875
] |
Advantages
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
sv
| 0.714283 |
PMC11279072_p44
|
PMC11279072
|
sec[1]/p[40]
|
Review
| 3.910156 |
biomedical
|
Other
|
[
0.9912109375,
0.00725555419921875,
0.0016021728515625
] |
[
0.019378662109375,
0.84326171875,
0.1339111328125,
0.003269195556640625
] |
Patients benefit directly from the notable improvement in surgical precision brought forth by hybrid laparoscopic procedures. Surgeons can accomplish more accuracy in difficult operations by fusing cutting-edge technologies such as robotics, endoscopy, and imaging systems with conventional laparoscopic techniques. With this accuracy, blood loss is reduced, adjacent tissues are damaged less, and diseased tissues are resected more completely. For example, hybrid approaches in cancer surgery allow for exact tumor margins, which raises the possibility of total tumor removal and lowers the chance of recurrence .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999997 |
PMC11279072_p45
|
PMC11279072
|
sec[1]/p[41]
|
Review
| 3.820313 |
biomedical
|
Review
|
[
0.994140625,
0.004100799560546875,
0.001827239990234375
] |
[
0.01502227783203125,
0.060150146484375,
0.923828125,
0.0010986328125
] |
Reduction of postoperative problems and recovery durations is one of the main advantages of hybrid laparoscopic methods. Smaller incisions, less discomfort after surgery, and shorter hospital stays are the outcomes of these minimally invasive procedures. When compared to those undergoing conventional open procedures, patients usually heal more quickly and resume their regular activities. Robotic-assisted laparoscopic prostatectomies and hybrid CABG are two procedures where studies have demonstrated hybrid techniques lead to fewer complications, lower infection rates, and faster recovery .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999996 |
PMC11279072_p46
|
PMC11279072
|
sec[1]/p[42]
|
Review
| 3.189453 |
biomedical
|
Other
|
[
0.98828125,
0.0086669921875,
0.002841949462890625
] |
[
0.0025844573974609375,
0.98876953125,
0.0072021484375,
0.00128936767578125
] |
Using hybrid laparoscopic procedures promotes multidisciplinary cooperation and creativity among surgical teams. Many times, these methods call for combining knowledge from several disciplines, including neurology, cardiothoracic surgery, urology, and general surgery. By working together, new surgical techniques are developed and best practices from many disciplines are shared. Using cutting-edge technology also promotes ongoing development and adaptation, expanding the possibilities of minimally invasive surgery .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999997 |
PMC11279072_p47
|
PMC11279072
|
sec[1]/p[43]
|
Review
| 0.994629 |
other
|
Other
|
[
0.250244140625,
0.014739990234375,
0.73486328125
] |
[
0.03192138671875,
0.9560546875,
0.007678985595703125,
0.00424957275390625
] |
Challenges
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
de
| 0.999944 |
PMC11279072_p48
|
PMC11279072
|
sec[1]/p[44]
|
Review
| 3.525391 |
biomedical
|
Other
|
[
0.98681640625,
0.01082611083984375,
0.0023899078369140625
] |
[
0.0161590576171875,
0.9755859375,
0.006893157958984375,
0.0014410018920898438
] |
Hybrid laparoscopic procedures have a steep learning curve for surgeons and considerable technological complexity despite their benefits. Learning these methods calls for specific education and expertise in both robotic systems and intraoperative imaging as well as conventional laparoscopic surgery. Surgeons may need a long period and considerable practice to become proficient because of the steep learning slope. Furthermore, it can be technically difficult and needs exact teamwork to combine several modalities during a single process .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999997 |
PMC11279072_p49
|
PMC11279072
|
sec[1]/p[45]
|
Review
| 2.392578 |
biomedical
|
Other
|
[
0.97705078125,
0.01020050048828125,
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] |
[
0.004802703857421875,
0.994140625,
0.0005421638488769531,
0.0005540847778320312
] |
Hybrid laparoscopic procedures need sophisticated tools and resources, which can be prohibitive for many medical institutions. Purchasing and maintaining robotic systems, cutting-edge imaging equipment, and specialist laparoscopic instruments are expensive endeavors. Surgeons, anesthesiologists, and support staff are among the skilled professionals that these operations need, along with well-equipped operating rooms. Resource limitations may lead to smaller hospitals or those with tighter resources finding it difficult to apply these strategies .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999997 |
PMC11279072_p50
|
PMC11279072
|
sec[1]/p[46]
|
Review
| 3.050781 |
biomedical
|
Other
|
[
0.96240234375,
0.028564453125,
0.00893402099609375
] |
[
0.0025272369384765625,
0.9951171875,
0.0015859603881835938,
0.0008864402770996094
] |
Including hybrid laparoscopic techniques in current surgical procedures can be difficult. These sophisticated methods may need to be accommodated by changes to conventional surgical procedures and protocols, which calls for meticulous preparation and coordination. Surgeon teams used to traditional techniques could also be resistant to change. A smooth integration requires that every team member be taught and at ease with the new methods. Moreover, it is imperative to create uniform norms and standards for hybrid laparoscopic operations to guarantee uniform and secure procedures at many medical facilities .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999998 |
PMC11279072_p51
|
PMC11279072
|
sec[1]/p[47]
|
Review
| 1.165039 |
other
|
Other
|
[
0.21728515625,
0.00839996337890625,
0.7744140625
] |
[
0.0079803466796875,
0.97900390625,
0.01122283935546875,
0.0017042160034179688
] |
Future directions and innovations
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999995 |
PMC11279072_p52
|
PMC11279072
|
sec[1]/p[48]
|
Review
| 1.110352 |
biomedical
|
Other
|
[
0.734375,
0.006359100341796875,
0.25927734375
] |
[
0.02471923828125,
0.96630859375,
0.007312774658203125,
0.00180816650390625
] |
Technological Advances
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999995 |
PMC11279072_p53
|
PMC11279072
|
sec[1]/p[49]
|
Review
| 3.505859 |
biomedical
|
Other
|
[
0.9912109375,
0.00628662109375,
0.0027141571044921875
] |
[
0.0085906982421875,
0.986328125,
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0.0008730888366699219
] |
Hybrid laparoscopic techniques are directly related to the creation and application of new technology. Robotic system improvements are always enhancing surgical control, dexterity, and precision. Next-generation robots with improved haptic feedback, machine learning algorithms, and AI can help surgeons perform complex maneuvers more easily and with more accuracy. In real-time, for example, AR overlays and AI-powered picture identification can highlight important anatomical components and possible risks during surgery .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999997 |
PMC11279072_p54
|
PMC11279072
|
sec[1]/p[50]
|
Review
| 3.794922 |
biomedical
|
Other
|
[
0.99658203125,
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[
0.06134033203125,
0.85400390625,
0.082763671875,
0.001678466796875
] |
A further interesting field is the development of less intrusive equipment with greater mobility and flexibility. Micro-robots, magnetically operated devices, and flexible endoscopes are just a few of the innovations that allow surgeons to reach difficult-to-reach places with little damage to nearby tissues. Furthermore improving the accuracy and safety of hybrid laparoscopic procedures is the real-time, high-resolution visualization of interior structures made possible by the incorporation of sophisticated imaging modalities, such as intraoperative MRI and CT scans .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999996 |
PMC11279072_p55
|
PMC11279072
|
sec[1]/p[51]
|
Review
| 1.155273 |
other
|
Other
|
[
0.372802734375,
0.01139068603515625,
0.61572265625
] |
[
0.007526397705078125,
0.97802734375,
0.01279449462890625,
0.00177001953125
] |
Future Trends and Potential Breakthroughs
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999994 |
PMC11279072_p56
|
PMC11279072
|
sec[1]/p[52]
|
Review
| 2.433594 |
biomedical
|
Other
|
[
0.9814453125,
0.0121002197265625,
0.00669097900390625
] |
[
0.001796722412109375,
0.99462890625,
0.0027027130126953125,
0.00098419189453125
] |
Looking ahead, several trends and potential breakthroughs are poised to shape the future of hybrid laparoscopic techniques. One such trend is the increasing use of telemedicine and remote surgery. With advancements in telecommunications and robotic systems, expert surgeons can perform or assist in complex procedures remotely, expanding access to specialized care and improving outcomes in underserved regions .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999996 |
PMC11279072_p57
|
PMC11279072
|
sec[1]/p[53]
|
Review
| 3.773438 |
biomedical
|
Other
|
[
0.9970703125,
0.002185821533203125,
0.0009074211120605469
] |
[
0.0289306640625,
0.83642578125,
0.1328125,
0.0016889572143554688
] |
Another significant trend is the development of personalized and precision surgery. Advances in genomics, proteomics, and metabolomics, combined with AI and big data analytics, are paving the way for tailored surgical interventions based on individual patient profiles. This approach can optimize surgical planning, reduce complications, and enhance recovery by considering each patient’s unique characteristics and risk factors .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999997 |
PMC11279072_p58
|
PMC11279072
|
sec[1]/p[54]
|
Review
| 1.132813 |
other
|
Other
|
[
0.181640625,
0.004459381103515625,
0.81396484375
] |
[
0.00572967529296875,
0.9912109375,
0.002346038818359375,
0.000827789306640625
] |
Training and Education
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999996 |
PMC11279072_p59
|
PMC11279072
|
sec[1]/p[55]
|
Review
| 3.919922 |
biomedical
|
Other
|
[
0.98779296875,
0.01099395751953125,
0.0014171600341796875
] |
[
0.029296875,
0.9423828125,
0.0257720947265625,
0.00257110595703125
] |
As hybrid laparoscopic techniques become more prevalent, there is a growing need for specialized training programs to equip surgeons with the necessary skills and knowledge. These programs should focus on the unique challenges and opportunities associated with hybrid techniques, including the use of advanced technologies, multidisciplinary collaboration, and complex procedural planning. Simulation-based training, using high-fidelity surgical simulators and virtual reality (VR) platforms, can provide a safe and effective environment for surgeons to practice and refine their skills before performing procedures on patients .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999998 |
PMC11279072_p60
|
PMC11279072
|
sec[1]/p[56]
|
Review
| 2.140625 |
biomedical
|
Other
|
[
0.9609375,
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0.0166168212890625
] |
[
0.005970001220703125,
0.98828125,
0.0037841796875,
0.0018100738525390625
] |
Incorporation of Hybrid Techniques in Surgical Education
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999997 |
PMC11279072_p61
|
PMC11279072
|
sec[1]/p[57]
|
Review
| 3.800781 |
biomedical
|
Other
|
[
0.9765625,
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0.0023040771484375
] |
[
0.006618499755859375,
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0.0131072998046875,
0.002620697021484375
] |
Incorporating hybrid techniques into surgical education is essential to ensure that future generations of surgeons are proficient in these advanced methods. Medical schools and residency programs should integrate hybrid laparoscopic training into their curricula, emphasizing both theoretical knowledge and practical skills. This integration should include comprehensive modules on the principles and applications of hybrid techniques, the use of advanced technologies such as robotics and imaging systems, and the management of complex surgical cases .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999995 |
PMC11279072_p62
|
PMC11279072
|
sec[1]/p[58]
|
Review
| 3.802734 |
biomedical
|
Other
|
[
0.9873046875,
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] |
[
0.0183868408203125,
0.96630859375,
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0.0021343231201171875
] |
Simulation-based training is a key component of this educational approach. High-fidelity surgical simulators and VR platforms can provide a safe and effective environment for students and residents to practice and refine their skills. These tools allow for the replication of complex surgical scenarios, enabling trainees to gain hands-on experience without risk to patients. Additionally, AR systems can offer real-time guidance and feedback, further enhancing the learning experience .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999997 |
PMC11279072_p63
|
PMC11279072
|
sec[1]/p[59]
|
Review
| 2.722656 |
biomedical
|
Other
|
[
0.94921875,
0.039764404296875,
0.011138916015625
] |
[
0.0012073516845703125,
0.99560546875,
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0.0013742446899414062
] |
Continuing medical education (CME) programs and workshops also play a crucial role in keeping practicing surgeons updated with the latest developments and best practices in hybrid surgery. These programs should offer opportunities for surgeons to learn about new technologies, refine their techniques, and stay current with evolving standards of care. CME activities can include hands-on workshops, live surgical demonstrations, and interactive lectures by experts in the field .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999996 |
PMC11279072_p64
|
PMC11279072
|
sec[1]/p[60]
|
Review
| 3.587891 |
biomedical
|
Other
|
[
0.98779296875,
0.0093231201171875,
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] |
[
0.005741119384765625,
0.984375,
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] |
Moreover, fostering a culture of lifelong learning and continuous improvement is vital for the successful integration of hybrid techniques into surgical practice. Surgeons should be encouraged to engage in ongoing professional development, participate in research, and contribute to the advancement of hybrid laparoscopic methods. Collaboration with interdisciplinary teams, including engineers, computer scientists, and biomedical researchers, can further enhance the educational experience and drive innovation in surgical techniques .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999998 |
PMC11279072_p65
|
PMC11279072
|
sec[1]/p[61]
|
Review
| 0.990723 |
other
|
Other
|
[
0.2890625,
0.004241943359375,
0.70654296875
] |
[
0.01560211181640625,
0.97998046875,
0.00302886962890625,
0.0014476776123046875
] |
Research opportunities
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999994 |
PMC11279072_p66
|
PMC11279072
|
sec[1]/p[62]
|
Review
| 1.401367 |
biomedical
|
Other
|
[
0.60400390625,
0.007556915283203125,
0.388427734375
] |
[
0.038970947265625,
0.94775390625,
0.0115203857421875,
0.0016183853149414062
] |
Areas Requiring Further Investigation
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999997 |
PMC11279072_p67
|
PMC11279072
|
sec[1]/p[63]
|
Review
| 3.908203 |
biomedical
|
Review
|
[
0.9970703125,
0.0023441314697265625,
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] |
[
0.12109375,
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] |
Despite the advancements in hybrid laparoscopic procedures, further research is necessary to fully optimize their use and outcomes. One critical area of investigation is the long-term safety and efficacy of these procedures compared to conventional techniques. Large-scale, multicenter randomized controlled trials are needed to provide robust evidence on the benefits and potential risks of hybrid techniques across various surgical specialties. Such studies will help establish the clinical value and reliability of hybrid laparoscopic methods .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999995 |
PMC11279072_p68
|
PMC11279072
|
sec[1]/p[64]
|
Review
| 3.849609 |
biomedical
|
Other
|
[
0.99853515625,
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] |
[
0.322998046875,
0.52685546875,
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0.001155853271484375
] |
Another significant research area is the development of new technologies and methodologies to overcome existing limitations. For instance, improving the ergonomics of surgical instruments and enhancing the efficiency of teaching tools are vital for the continued evolution of hybrid laparoscopic surgery. Advanced ergonomic designs can reduce surgeon fatigue and improve precision during lengthy procedures, while innovative teaching tools, such as VR simulations and AR guidance, can provide more effective training for surgeons .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999997 |
PMC11279072_p69
|
PMC11279072
|
sec[1]/p[65]
|
Review
| 3.962891 |
biomedical
|
Review
|
[
0.99609375,
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[
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0.0526123046875,
0.6162109375,
0.00067901611328125
] |
Additionally, investigating the cost-effectiveness and impact of hybrid laparoscopic procedures on healthcare systems is essential to support their widespread adoption. Understanding the economic implications, including initial investment, maintenance costs, and long-term savings from reduced complication rates and shorter hospital stays, will help healthcare providers make informed decisions about implementing these advanced techniques. Comprehensive cost-benefit analyses and health economic studies can provide valuable insights into the financial viability and potential benefits of hybrid laparoscopic surgery for both patients and healthcare systems .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999995 |
PMC11279072_p70
|
PMC11279072
|
sec[1]/p[66]
|
Review
| 1.12793 |
other
|
Other
|
[
0.212646484375,
0.002384185791015625,
0.78466796875
] |
[
0.0027332305908203125,
0.9951171875,
0.0014705657958984375,
0.0004801750183105469
] |
Potential for Interdisciplinary Research Collaborations
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999996 |
PMC11279072_p71
|
PMC11279072
|
sec[1]/p[67]
|
Review
| 3.230469 |
biomedical
|
Other
|
[
0.99365234375,
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] |
[
0.006259918212890625,
0.9814453125,
0.01154327392578125,
0.0007405281066894531
] |
The complexity and multidisciplinary nature of hybrid laparoscopic techniques offer significant potential for interdisciplinary research collaborations. Combining expertise from fields such as engineering, computer science, biomedical sciences, and clinical medicine can drive innovation and address the challenges associated with these techniques. Collaborative research initiatives can lead to the development of new technologies, improved surgical protocols, and better patient outcomes .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999996 |
PMC11279072_p72
|
PMC11279072
|
sec[1]/p[68]
|
Review
| 3.320313 |
biomedical
|
Other
|
[
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0.00353240966796875,
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] |
[
0.007648468017578125,
0.98583984375,
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0.0009260177612304688
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For instance, the integration of advanced imaging technologies and robotics in hybrid laparoscopic surgery requires the expertise of engineers and computer scientists to develop and refine these systems. Biomedical scientists contribute to understanding the biological implications and optimizing the use of these technologies, while clinical practitioners provide practical insights and validate the effectiveness of new approaches through clinical trials and patient care .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999996 |
PMC11279072_p73
|
PMC11279072
|
sec[1]/p[69]
|
Review
| 3.660156 |
biomedical
|
Other
|
[
0.99169921875,
0.006664276123046875,
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] |
[
0.0173797607421875,
0.97607421875,
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0.0013360977172851562
] |
One area ripe for interdisciplinary collaboration is the enhancement of real-time imaging and visualization techniques during surgery. Innovations such as AR and AI can be integrated into hybrid laparoscopic systems to provide surgeons with enhanced guidance and decision-making support. AR can overlay critical anatomical information onto the surgeon’s field of view, while AI algorithms can analyze intraoperative data to predict outcomes and suggest optimal surgical maneuvers.
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999997 |
PMC11279072_p74
|
PMC11279072
|
sec[1]/p[70]
|
Review
| 3.619141 |
biomedical
|
Other
|
[
0.998046875,
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] |
[
0.11212158203125,
0.87744140625,
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0.0007214546203613281
] |
Furthermore, collaborations between clinical researchers and data scientists can lead to the development of predictive models that improve patient selection and surgical planning. By analyzing large datasets of surgical outcomes, researchers can identify patterns and factors that contribute to successful procedures, thereby refining patient eligibility criteria and tailoring surgical techniques to individual needs .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999995 |
PMC11279072_p75
|
PMC11279072
|
sec[1]/p[71]
|
Review
| 3.498047 |
biomedical
|
Other
|
[
0.99609375,
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0.0012884140014648438
] |
[
0.035125732421875,
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] |
Interdisciplinary research collaborations also have the potential to address the educational and training needs associated with hybrid laparoscopic techniques. Developing comprehensive training programs that incorporate VR simulations and hands-on practice can ensure that surgeons are well-prepared to perform these complex procedures. These programs can be designed and evaluated through collaborative efforts between medical educators, VR developers, and clinical experts .
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999996 |
PMC11279072_p76
|
PMC11279072
|
sec[2]/p[0]
|
Conclusions
| 3.402344 |
biomedical
|
Other
|
[
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[
0.0031452178955078125,
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0.0386962890625,
0.0025119781494140625
] |
A major development in the field of surgery, hybrid laparoscopic procedures provide previously unheard-of precision, shortened recovery periods, and improved results in a broad spectrum of intricate interdisciplinary cases. The combination of modern technology and conventional surgical expertise in these techniques creates a new age of minimally invasive operations that can be used in gastrointestinal, cardiothoracic, urological, and gynecological surgeries, among other medical specialties.
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999996 |
PMC11279072_p77
|
PMC11279072
|
sec[2]/p[1]
|
Conclusions
| 3.380859 |
biomedical
|
Other
|
[
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[
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] |
There have been significant advancements in both surgical practice and technology along the path from traditional laparoscopic techniques to hybrid procedures. Robotic systems, cutting-edge imaging modalities, and flexible equipment have revolutionized surgery, making minimally invasive operations that were previously thought to be too complicated or dangerous possible. Because surgeons now have to adjust to the complexity and demands of these cutting-edge procedures, this development emphasizes the need for interdisciplinary cooperation and ongoing education.
|
[
"Muhammad Junaid Cheema",
"Muhammad Mustaneer Ul Hassan",
"Aiman Asim",
"Eemaz Nathaniel",
"Mohamed Ishraq Shafeeq",
"Muhammad Abbas Tayyab",
"Cijal Rahim Valiyakath",
"Shenouda Abdallah",
"Ali Usman"
] |
https://doi.org/10.7759/cureus.63219
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999996 |
PMC11279084_p0
|
PMC11279084
|
sec[0]/p[0]
|
1. Introduction
| 4.378906 |
biomedical
|
Review
|
[
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[
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The prevalence of inflammatory bowel diseases (IBDs), including Crohn’s disease (CD) and ulcerative colitis (UC), is on the increase . Although the pathophysiology of IBDs is, to an extent, unknown, it is believed that they are of multifactorial etiology, where some environmental factors (such as stress, pollution, pathogen infections, smoking) act on a genetic background, resulting in persistent gastrointestinal tract inflammation . Moreover, gut microbiota and immunological imbalance play a pivotal role in the pathogenesis . Among environmental factors, diet is widely believed to play an important role in the progression of IBDs . Despite the fact that the precise pathophysiological mechanisms are still unclear, several possible explanations have been suggested. Diet seems to play an important part in the equilibrium of gut microenvironment, having an effect on the gut’s microbial composition and functioning . Furthermore, the nutritional patterns and habits followed by the developed Western countries, including high intake of red meat, refined carbohydrates, ultraprocessed and industrialized foods, high total fat, and especially saturated fat, foods, and low quantity of vegetables, fruit, and legumes, have been associated with increased mucosal inflammation and decreased amount of bacteria involved in fiber degradation .
|
[
"Athanasios Migdanis",
"Ioannis Migdanis",
"Nikoleta D. Gkogkou",
"Sousana K. Papadopoulou",
"Constantinos Giaginis",
"Athanasios Manouras",
"Maria Anna Polyzou Konsta",
"Rena I. Kosti",
"Konstantinos A. Oikonomou",
"Konstantinos Argyriou",
"Spyridon Potamianos",
"Andreas Kapsoritakis"
] |
https://doi.org/10.3390/medicina60071106
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999995 |
PMC11279084_p1
|
PMC11279084
|
sec[0]/p[1]
|
1. Introduction
| 3.798828 |
biomedical
|
Review
|
[
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[
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In comparison to the Western-style diet, the Mediterranean diet (MD) is a more plant-based dietary model which consists of high amounts of vegetables and fruit (rich in antioxidants and vitamins), nuts, cereal, and extra virgin olive oil (rich in monounsaturated fatty acids), a moderate consumption of poultry, fish, and dairy products, and a low intake of processed red meat products and saturated fats . The Mediterranean diet has gained recognition as a balanced beneficial nutritional model that lowers the risks of a variety of pathological states and human disorders and promotes human health . Although the scientific literature supports a beneficial effect of Mediterranean diet on chronic conditions such as cardiovascular disease, metabolic disorders, some types of cancer, and neurological diseases , the influence of MD on IBDs remains unclear.
|
[
"Athanasios Migdanis",
"Ioannis Migdanis",
"Nikoleta D. Gkogkou",
"Sousana K. Papadopoulou",
"Constantinos Giaginis",
"Athanasios Manouras",
"Maria Anna Polyzou Konsta",
"Rena I. Kosti",
"Konstantinos A. Oikonomou",
"Konstantinos Argyriou",
"Spyridon Potamianos",
"Andreas Kapsoritakis"
] |
https://doi.org/10.3390/medicina60071106
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999997 |
PMC11279084_p2
|
PMC11279084
|
sec[0]/p[2]
|
1. Introduction
| 4.203125 |
biomedical
|
Study
|
[
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[
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The exact mechanisms underpinning the association between MD and IBDs seem to be yet unspecified, although several potential hypotheses have been proposed. Research has shown that features of the Mediterranean diet, such as intake of vegetables, fruits, red wine, yogurt, nuts, and fish, have been associated with increased microbial diversity and benefits on gut microbiota in healthy individuals . In studies conducted on patients with CD and UC, the results showed that Mediterranean diet interventions can significantly alter gut microbiota composition, increasing abundances of Faecalibacterium, Alistipes finegoldii, Ruminococcus bromii, and total short-chain fatty acid (SCFA) concentrations . SCFAs such as acetate and butyrate can help maintain mucosal barrier function and modulate immune function in IBDs . Other studies have also demonstrated that following an MD can have an effect in modulating the expression of inflammation associated genes and indicate a potential favorable anti-inflammatory effect . The anti-inflammatory effects of the MD might also derive from the high intake of antioxidants such as polyphenols and polyunsaturated fatty acids (omega 3/6) intake, which are believed to fuel the inflammatory process .
|
[
"Athanasios Migdanis",
"Ioannis Migdanis",
"Nikoleta D. Gkogkou",
"Sousana K. Papadopoulou",
"Constantinos Giaginis",
"Athanasios Manouras",
"Maria Anna Polyzou Konsta",
"Rena I. Kosti",
"Konstantinos A. Oikonomou",
"Konstantinos Argyriou",
"Spyridon Potamianos",
"Andreas Kapsoritakis"
] |
https://doi.org/10.3390/medicina60071106
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999997 |
PMC11279084_p3
|
PMC11279084
|
sec[0]/p[3]
|
1. Introduction
| 4.070313 |
biomedical
|
Study
|
[
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] |
[
0.9990234375,
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Although research in the existing literature has detected some beneficial effects of MD on gut microbiota and the mucosal inflammation process and has tried to assess the level of compliance of the MD in IBD patients in general, and more specifically between active and inactive disease phase, the scientific evidence on the effect of MD on clinical or laboratory disease activity and QoL of IBD patients is still very limited. The main aim of the present study is to provide some insight into the relationship between the adherence to the MD and the degree of disease activity, as well as the QoL in patients with CD, in a Greek population (a very understudied population).
|
[
"Athanasios Migdanis",
"Ioannis Migdanis",
"Nikoleta D. Gkogkou",
"Sousana K. Papadopoulou",
"Constantinos Giaginis",
"Athanasios Manouras",
"Maria Anna Polyzou Konsta",
"Rena I. Kosti",
"Konstantinos A. Oikonomou",
"Konstantinos Argyriou",
"Spyridon Potamianos",
"Andreas Kapsoritakis"
] |
https://doi.org/10.3390/medicina60071106
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999998 |
PMC11279084_p4
|
PMC11279084
|
sec[1]/p[0]
|
2. Materials and Methods
| 4.0625 |
biomedical
|
Study
|
[
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0.0002608299255371094
] |
[
0.99951171875,
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0.00022685527801513672,
0.0001347064971923828
] |
This was a study with a cross-sectional design. The study was initiated in June 2020 and completed in February 2021. The study was conducted among 60 male and female patients diagnosed with CD. An administered questionnaire was used to assess and record a number of parameters, including recent medical and weight history, level of education, anthropometric characteristics, disease activity, and quality of life. Sample collection was carried out in the outpatient’s clinic of the Gastroenterology unit of General University Hospital of Larissa, the Hellenic Society of Crohn’s Disease and Ulcerative Colitis patients, and a private gastroenterology practice. The questionnaires were administered both in printed form and electronically. A registered dietitian was available during administration in case of needed clarifications. Participants who had a chronic or acute condition (e.g., food allergies, pancreatitis, had undergone major surgery, were undergoing chemo/radiotherapy, or had a recent infection) that might have had an impact on their recent nutritional state were excluded from the study. Patients were included if they were >15 years old and were diagnosed with CD. From all the patients that met the eligibility criteria for inclusion, 15 patients, 9 male and 6 female, refused to take part in the study.
|
[
"Athanasios Migdanis",
"Ioannis Migdanis",
"Nikoleta D. Gkogkou",
"Sousana K. Papadopoulou",
"Constantinos Giaginis",
"Athanasios Manouras",
"Maria Anna Polyzou Konsta",
"Rena I. Kosti",
"Konstantinos A. Oikonomou",
"Konstantinos Argyriou",
"Spyridon Potamianos",
"Andreas Kapsoritakis"
] |
https://doi.org/10.3390/medicina60071106
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999998 |
PMC11279084_p5
|
PMC11279084
|
sec[1]/p[1]
|
2. Materials and Methods
| 4.171875 |
biomedical
|
Study
|
[
0.99853515625,
0.0012941360473632812,
0.00016260147094726562
] |
[
0.99853515625,
0.0005288124084472656,
0.0009775161743164062,
0.00017511844635009766
] |
More specifically, the disease activity of the participants was assessed with the Harvey-Bradshaw Index (HBI), a clinical tool for assessment of disease activity in patients with Crohn’s disease . The tool consists of a few questions that allow the evaluation of CD’s degree of illness (severity) and detect remission. It has been developed to quantify the symptoms of the disease, including questions regarding general wellbeing, abdominal pain, stool consistency, and complications related to the disease (e.g., uveitis, arthralgia, abscess, etc.). In order to assess the quality of life (QoL) of the participants, the Crohn’s and ulcerative colitis questionnaire CUCQ-8 was used . This is a shorter version of the more lengthy CUCQ-32 and is a validated tool to assess the QoL of patients with IBD. The CUCQ-8 questionnaire evaluates intestinal problems in the prior 2 weeks and their effects on QoL. It assesses loose or runny bowel movement, tiredness, frustration, urgency or awakening at night to use the toilet, and social inhibition. The total score is 0 to 24, and the higher the score, the lower the QoL. Several biochemical markers, including serum hemoglobin (gr/dL), hematocrit (%), C-reactive protein (CRP) (mg/L), albumin (g/dl), glucose (mg/dL), alkaline phosphatase (IU/L), glutamic–oxaloacetic transaminase SGOT (IU/L), glutamic–pyruvic transaminase SGPT (IU/L), γ-glutamyl transferase γ-GT (IU/L), amylase (IU/L), lactate dehydrogenase (U/L), vitamin B12 (pg/mL), triglycerides (mg/dL), folic acid (ng/mL), white blood cells (K/μL), and potassium (mmol/L), were also measured and quantified with an automatic biochemical analyzer in all participants. All patients that agreed to participate in the study were asked to visit the hospital’s outpatient clinic on a morning that was convenient for them, after overnight fasting, where blood sample collection by a registered nurse took place. Appetite and nutritional status of the participants was evaluated via nutrition risk screening 2002 and simplified nutritional appetite questionnaire . Physical activity of the participants was assessed using physical activity level (PAL) categories according to lifestyle .
|
[
"Athanasios Migdanis",
"Ioannis Migdanis",
"Nikoleta D. Gkogkou",
"Sousana K. Papadopoulou",
"Constantinos Giaginis",
"Athanasios Manouras",
"Maria Anna Polyzou Konsta",
"Rena I. Kosti",
"Konstantinos A. Oikonomou",
"Konstantinos Argyriou",
"Spyridon Potamianos",
"Andreas Kapsoritakis"
] |
https://doi.org/10.3390/medicina60071106
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999997 |
PMC11279084_p6
|
PMC11279084
|
sec[1]/p[2]
|
2. Materials and Methods
| 3.914063 |
biomedical
|
Study
|
[
0.98681640625,
0.01270294189453125,
0.0006256103515625
] |
[
0.93310546875,
0.0640869140625,
0.0015344619750976562,
0.0012025833129882812
] |
The level of adherence of the participants to the Mediterranean diet model was evaluated using the Mediterranean diet score tool (MedDiet score) . The MedDiet score is a tool created to assess the adherence of a population to the Mediterranean diet, which has been acknowledged worldwide as a model for a healthy and balanced diet. The MedDiet score tool particularly uses 11 main components of the Mediterranean diet (legumes, olive oil, poultry, red meat, nonrefined cereals, vegetables, fruits, fish, potatoes, dairy products, and alcohol). To evaluate the level of consumption of the above food groups, a 5-point scale is used, ranging from 0 = no consumption to 5 = daily consumption, respectively. Informed consent was obtained from all participants before entering the study. The trial protocol was approved by the Ethics Committee of the University of Thessaly , and adhered at all times to the Helsinki Declaration.
|
[
"Athanasios Migdanis",
"Ioannis Migdanis",
"Nikoleta D. Gkogkou",
"Sousana K. Papadopoulou",
"Constantinos Giaginis",
"Athanasios Manouras",
"Maria Anna Polyzou Konsta",
"Rena I. Kosti",
"Konstantinos A. Oikonomou",
"Konstantinos Argyriou",
"Spyridon Potamianos",
"Andreas Kapsoritakis"
] |
https://doi.org/10.3390/medicina60071106
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999997 |
PMC11279084_p7
|
PMC11279084
|
sec[1]/sec[0]/p[0]
|
Statistical Analysis
| 3.943359 |
biomedical
|
Study
|
[
0.99951171875,
0.0002925395965576172,
0.00027108192443847656
] |
[
0.9990234375,
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Statistical analysis was conducted using Statistical Product and Service Solutions, version 26 (IBM SPSS Statistics for Windows, Armonk, NY, USA). To determine the normality of the distribution of the examined variables, the Kolmogorov–Smirnov test was carried out. Continuous variables such as anthropometric characteristics and age are presented as means and ±standard deviations, and ordinal or categorical variables are presented as percentages (%). To assess possible differences in different measured parameters between active and inactive disease patients, chi-square test, independent samples t-test, and Mann–Whitney U-test were conducted. To examine possible correlations between MedDiet Score and disease activity or QoL, Pearson’s r and Spearman’s rho correlation coefficients were used. Statistical significance is reported as p < 0.05.
|
[
"Athanasios Migdanis",
"Ioannis Migdanis",
"Nikoleta D. Gkogkou",
"Sousana K. Papadopoulou",
"Constantinos Giaginis",
"Athanasios Manouras",
"Maria Anna Polyzou Konsta",
"Rena I. Kosti",
"Konstantinos A. Oikonomou",
"Konstantinos Argyriou",
"Spyridon Potamianos",
"Andreas Kapsoritakis"
] |
https://doi.org/10.3390/medicina60071106
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999996 |
PMC11279084_p8
|
PMC11279084
|
sec[2]/p[0]
|
3. Results
| 4.03125 |
biomedical
|
Study
|
[
0.99853515625,
0.001033782958984375,
0.0002911090850830078
] |
[
0.99951171875,
0.00024819374084472656,
0.0002168416976928711,
0.00009912252426147461
] |
A total of 60 participants consented and were recruited for the study. The mean age of the participants was 37.6 ± 12.5 (36.7% males and 63.3% females). The participants’ mean BMI was slightly above the normal range (25.1 ± 5.7 kg/m 2 ), which falls within the overweight category. More specifically, 21.7% and 16.7% of the participants in the study were overweight and obese, respectively ( Table 1 ). Regarding the disease activity according to HBI and QoL using the CUCQ-8, participants had a mean score of 5.65 ± 5.2 and 9.3 ± 5.8, respectively ( Table 1 ). Furthermore, participants scored a mean of 30 ± 3.6 on the MedDiet Score, where the score ranges from 0 to 55, with higher values indicating greater adherence to the Mediterranean diet ( Table 1 ).
|
[
"Athanasios Migdanis",
"Ioannis Migdanis",
"Nikoleta D. Gkogkou",
"Sousana K. Papadopoulou",
"Constantinos Giaginis",
"Athanasios Manouras",
"Maria Anna Polyzou Konsta",
"Rena I. Kosti",
"Konstantinos A. Oikonomou",
"Konstantinos Argyriou",
"Spyridon Potamianos",
"Andreas Kapsoritakis"
] |
https://doi.org/10.3390/medicina60071106
|
N/A
|
https://creativecommons.org/licenses/by/4.0/
|
en
| 0.999997 |