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What are positively charged, thus allowing the compaction of the negatively charged DNA?
the histone subunits
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How are the histone subunits charged?
positively charged
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What are illustrated?
the principal cellular alterations that characterize reversible cell injury and necrosis
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What is considered to culminate in necrosis if the injurious stimulus is not removed, by convention?
reversible injury
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How is reversible injury considered to do if the injurious stimulus is not removed, by convention?
culminate in necrosis
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What is showing increased eosinophilia of cytoplasm, and swelling of occasional cells?
early (reversible) ischemic injury
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What does ischemic injury show?
surface blebs
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What show preserved outlines with loss of nuclei?
the necrotic cells
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What shows a circumferential bright pink area of necrosis with protein deposition and inflammation?
the wall of the artery
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What does the wall of the artery show with protein deposition and inflammation?
a circumferential bright pink area of necrosis
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How does the wall of the artery show a circumferential bright pink area of necrosis?
with protein deposition and inflammation
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What are illustrated?
the cellular alterations in apoptosis are illustrated
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What are shown?
apoptotic cells in colonic epithelium
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What was removed for postpartum bleeding?
a gravid uterus
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What was a gravid uterus removed for?
postpartum bleeding
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What is surrounded by multiple multinucleate giant cells, epithelioid cells, and lymphocytes?
an area of central necrosis
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What does typical tuberculous granuloma show?
an area of central necrosis
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What is an area of central necrosis surrounded by?
multiple multinucleate giant cells
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What overlies white fibrous scar?
thrombus
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What does thrombus in the left and right ventricular apices overlie?
white fibrous scar
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What are super-imposed on advanced atherosclerotic lesions of the more proximal aorta (left side of photograph)?
friable mural thrombi
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What is characterized by vasodilation, congestion, and edema?
the immediate reaction
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What is the immediate reaction characterized by?
vasodilation
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What shows several multinucleate giant cells?
the granuloma
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What does the granuloma in the center show?
multinucleate giant cells
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What stain shows C4d deposition in peritubular capillaries and a glomerulus?
immunoperoxidase stain
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What are strikingly similar to normal squamous epithelial cells, with intercellular bridges and nests of keratin?
the tumor cells
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How are the tumor cells?
strikingly similar to normal squamous epithelial cells
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How are the tumor cells strikingly similar to normal squamous epithelial cells?
with intercellular bridges and nests of keratin (arrow)
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What shows failure of normal differentiation, marked nuclear and cellular pleomorphism, and numerous mitotic figures extending toward the surface?
high-power view of another region
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What does high-power view of another region show?
failure of normal differentiation
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What is not seen in this section?
the intact basement membrane
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What illustrates the invasion of breast stroma and fat by nests and cords of tumor cells?
the microscopic view of breast carcinoma
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What does microscopic view of breast carcinoma illustrate?
the invasion of breast stroma and fat by nests and cords of tumor cells
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How does microscopic view of breast carcinoma illustrate the invasion of breast stroma and fat?
by nests and cords of tumor cells
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What has been termed cystic hygroma?
fluid accumulation particularly prominent in the soft tissues of the neck
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What has this condition been termed?
cystic hygroma
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What are characteristically seen with, but not limited to, constitutional chromosomal anomalies such as 45, X karyotypes?
cystic hygromas
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What are cystic hygromas characteristically seen with, but not limited to?
constitutional chromosomal anomalies such as 45
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What is seen abutting the optic nerve?
poorly cohesive tumor in retina
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What is the poorly cohesive tumor in the retina seen abutting?
the optic nerve
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What is consistented with the blastemal component and interspersed primitive tubules, representing the epithelial component?
wilms tumor with tightly packed blue cells
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What is the Wilms tumor with tightly packed blue cells consistent with?
the blastemal component and interspersed primitive tubules
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What was present in other areas within this Wilms tumor, characterized by cells with hyperchromatic, pleomorphic nuclei, and an abnormal mitosis (center of field)?
focal anaplasia
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What was present within this Wilms tumor, characterized by cells with hyperchromatic, pleomorphic nuclei, and an abnormal mitosis center of field?
focal anaplasia
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What are associated with specific molecular lesions?
predominance of blastemal morphology and diffuse anaplasia
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What are predominance of blastemal morphology and diffuse anaplasia associated with?
specific molecular lesions
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What does not occur in the absence of appropriate T-cell-mediated immunity?
granulomatous host response
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What shows massive intracellular macrophage infection with acid-fast organisms (filamentous and pink in this acid-fast stain preparation)?
mycobacterium avium infection
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What does mycobacterium avium infection in a duodenal biopsy from a patient with AIDS show?
massive intracellular macrophage infection with acid-fast organisms
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What is AIDS?
acquired immunodeficiency syndrome
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What is composed of fibrous plaques?
aorta with mild atherosclerosis
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What is aorta with mild atherosclerosis composed of?
fibrous plaques
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What shows scattered inflammatory cells, calcification arrowheads, and neovascularization ?
high-power view of the junction of the fibrous cap and core
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What did high-power view of the junction of the fibrous cap and core show?
scattered inflammatory cells
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What demonstrate sheets of plump, proliferating spindle cells and slitlike vascular spaces?
histologic view of the nodular stage
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What is concentric thickening of the left ventricular wall causing?
reduction in lumen size
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What is causing reduction in lumen size?
concentric thickening of the left ventricular wall
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What are shown on the right in this four-chamber view of the heart?
the left ventricle and left atrium
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Where is the atrium shown?
on the right in this four-chamber view of the heart
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What is presented incidentally in the right ventricle?
a pacemaker
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Where is the pacemaker?
in the right ventricle
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What are heaped up within the sinuses of Valsalva?
nodular masses of calcium
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What are nodular masses of calcium heaped up within?
the sinuses valsalva
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What are not fused, as in rheumatic aortic valve stenosis?
the commissures
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How are the commissures stenosis?
not fused
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One cusp has a partial fusion at whose center ?
its
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One cusp has a partial fusion at whose center ?
its
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What is dilated, reflecting long-standing valvular insufficiency and volume overload?
the atrium
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What is prominent hooding with?
prolapse of the posterior mitral leaflet into the left atrium
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What is there with prolapse of the posterior mitral leaflet into the left atrium?
prominent hooding
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What is shown on the right in this four-chamber view?
the left ventricle
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Where is the left ventricle shown in this four-chamber view?
on the right
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What is caused by Streptococcus viridans on a previously myxomatous mitral valve?
subacute endocarditis
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What is subacute endocarditis caused by?
streptococcus viridans on a previously myxomatous mitral valve
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How is subacute endocarditis caused?
by streptococcus viridans on a previously myxomatous mitral valve
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How much dilation and hypertrophy are evident?
four
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What is evident?
four-chamber dilation and hypertrophy
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How are four-chamber dilation and hypertrophy?
evident
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What shows an irreversibly sickled cell in the center?
higher magnification
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What does higher magnification show in the center?
an irreversibly sickled cell
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What shows a hyper-segmented neutrophil with a six-lobed nucleus?
a peripheral blood smear
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What does a peripheral blood smear show?
a hyper-segmented neutrophil with a six-lobed nucleus
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How does a peripheral blood smear show a hyper-segmented neutrophil?
with a six-lobed nucleus
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What is seen lying within a clear space created by retraction of its cytoplasms?
a distinctive lacunar cell with a multilobed nucleus containing many small nucleoli
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What does the multilobed nucleus of the distinctive lacunar cell contain?
many small nucleoli
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A distinctive lacunar cell with a multilobed nucleus containing many small nucleoli is seen lying within a clear space created by retraction of whose cytoplasms ?
its
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What shows well-defined bands of pink, acellular collagen that have subdivided the tumor cells into nodules?
a low-power view
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What is surrounded by eosinophils, lymphocytes, and histiocytes?
a diagnostic
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What is a diagnostic, binucleate Reed-Sternberg cell surrounded by?
eosinophils
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What results for the AML are shown in the figure?
flow cytometry
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What are positive for the stem cell marker CD34 and the myeloid lineage specific markers CD33 and CD15 subset?
the tumor cells
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What are the tumor cells positive for?
the stem cell marker cd34 and myeloid lineage specific markers cd33 and cd15
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What is marked by resorption of hyaline membranes and thickening of alveolar septa by inflammatory cells, fibroblasts, and collagen?
the healing stage
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What is the healing stage marked by?
resorption of hyaline membranes and thickening of alveolar septa by inflammatory cells
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What are seen at this stage, associated with regeneration and repair?
numerous reactive type ii pneumocytes
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What are numerous reactive type II pneumocytes seen at, associated with regeneration and repair?
this stage
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What is seen in small arteries?
plexiform lesion
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Where is plexiform lesion characteristic of advanced pulmonary hypertension seen?
in small arteries
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What is infiltrated by macrophages and fibroblasts?
fibromyxoid masses
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