UniProt ID
stringlengths 6
10
| Protein Sequence
stringlengths 2
35.2k
| Functional Description
stringlengths 5
30.7k
|
|---|---|---|
Q48UB9
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MKLIYTEMSYSMTEILVNEARKAADQGYRVFYIAPNSLSFEKEREVLTLLPERGTFSIIVTRFVQMSRYFTVESSPSKQHLDDTTLAMIFYRALMQLKPEDLPSYGRLQNNSVFIEQLVELYKELKNAQLSVHDLTGLDHPQKQEDLIKIIELAETIMIQQDYNQDSPLQSFARAIKLGLLNNQLSKTVIVIDGFSRFSAEEDYLLSLLNNNCQEVIIGSYVSQKAYQKSFIKGNIYEASLHFLQDLAQKYHIKPVFATSNQVFKPAFSRLTQLFEATHDFSQVDWQLQKNDLDHFSLWQCHHQKEEIEHVAKSIRQKLYEGYRYKDILVLLGDMDAYQLQIGPIFDKFEIPYYLGKAEPMAAHPLVQFIESLERSQRYNWRREDILNMLKSGLFGCFDDSDIDRFEEYTQFADIKGFTKFSKPFTINSSRQYPLDFLNEMRQDIVLPLQELFKSQKQLGASLVDKLILFFKKIRLAENMQGLAQSQLEVEKNEEVWKRFTDILTSFHHIFGQEKLRLSDCLALIKTGMKSAQYRVVPATLDVVTIKSYDLVQPHSKPFVYAIGLTQSHFPKQIHHSGLLSDQERARINEIRNYRHFDIASAENSKKNHQTALSLFNAATKELVLSVPTVINETFDDLSPYLKELISFGLPLLDKGKNYLSYDNSDIGNYKALLSQIIAINRQDLIEMSDQDKMFWTVVLRYLRKQLRKQQLELPTSDYRLSTKPLSKEVIEVCFPKGIPLKLSATALTVFYNNQYNYFLKYVLNLNKTESIHPDSRIHGQYLHRVFERLMKDHTQEPFDNKLKQAIYHTNQESFFQQVYQDNAEAEYSLAILEDIVRSTAPILQLNQNIKVIDQEKNFHLDMGNEILVHGIIDRIDQLSDGSLGIVDYKSSANQFDIGTFYNGLSPQLVTYLAALKQIAPHDINQLFGAMYLHLQDPKLDLVTFKQIDNTLVESIYKALTYKGIFSEVEKEHLSTGAYQTKNALYSNDELETLLNYNKYLYLKAAKHIKKGHFLINPYTSDGKTVQGDQLKAITRFEADLDMAQARRLVTLPAKEKKECFLTLMRKESHL
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The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity. ATP + H2O = ADP + H(+) + phosphate Heterodimer of AddA and RexB. Belongs to the helicase family. AddB/RexB type 2 subfamily.
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Q97QQ0
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MKLLYTDIRTSLTEILTREAEELVAAGKRVFYIAPNSLSFEKERAVLEYLSQQASFSITVTRFAQMARYLVLNDLPAKTTLDDIGLGLAFYKCLAELDPKDLRVYGAIKQDPQLIQQLIELYHEMTKSQMSFLDLENLTDEDKRADLLLIFEKVTAYLNQGQLAQESQLSHLIEAIENDKVSSDFNQIALVIDGFTRFSAEEERVVDLLHGKGVEIVIGAYASKKAYTSPFSEGNLYQASVKFLHHLASKYQTPAQDCSQTHEKMDSFDKASRLLESSYDFSELALDVDEKDRENLQIWSCLTQKEELELVARSIRQKLHENSDLSYKHFRILLGDVASYQLSLKTIFDQYQIPFYLGRSEAMAHHPLTQFVESILALKRYRFRQEDLINLLRTDLYTDLSQSDIDAFEQYIRYLGINGLPAFQQTFTKSHHGKFNLERLNVLRLRILAPLETLFASRKQKAEKLLQKWSVFLKEGAVTKQLQDLTTTLEAVEQERQAEVWKAFCHVLEQFATVFAGSQVSLEDFLALLHSGMSLSQYRTIPATVDTVLVQSYDLIAPLTADFVYAIGLTQDNLPKISQNTSLLTDEERQNLNQATEEGVQLLIASSENLKKNRYTMLSLVNSARKQLFLSAPSLFNESESKESAYLQELIHFGFRRREKRMNHKGLSKEDMGSYHSLLSSLVAYHQQGEMSDTEQDLTFVKVLSRVIGKKLDQQGLENPAIPTSPSSKTLAKDTLQALYPAKQEFYLSTSGLTEFYRNEYSYFLRYVLGLQEELRLHPDARSHGNFLHRIFERALQLPNEDSFDQRLEQAIQETSQEREFEAIYQESLEAQFTKEVLLDVARTTGHILRHNPAIETIKEEANFGGKDQAFIQLDNGRSVFVRGKVDRIDRLKANGAIGVVDYKSSLTQFQFPHFFNGLNSQLPTYLAALKREGEQNFFGAMYLEMAEPVQSLMAVKSLAGAVVEASKSMKYQGLFLEKESSYLGEFYNKNKANQLTDEEFQLLLDYNAYLYKKAAEKILAGRFAINPYTENGRSIAPYVQQHQAITGFEANYHLGQARFLEKLDLADGKRLVGEKLKQAWLEKIREELNR
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Involved in DNA double-strand break repair. Is not involved in recombination during natural competence or in plasmid establishment. The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity. ATP + H2O = ADP + H(+) + phosphate Heterodimer of AddA and RexB. Cells lacking this gene grow poorly, are more sensitive to UV light than wild-type cells and have reduced double-strand exonuclease activity. Belongs to the helicase family. AddB/RexB type 2 subfamily.
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Q8K816
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MKLIYTEMSYSMTEILVNEARKAADQGYRVFYIAPNSLSFEKEREVLTLLPERGTFSIIVTRFVQMSRYFTVESSPSKQHLDDTTLAMIFYRALMQLKPEDLPSYGRLQNNSVFIEQLVELYKELKNAQLSVHDLTGLDHPQKQEDLIKIIELAETIMIQQDYNQDSPLQSFARAIKLGLLNNQLSKTVVVIDGFSRFSAEEDYLLSLLNNNCQEVIIGSYVSQKAYQKSFIKGNIYEASLHFLQDLAQKYHIKPVFATSNQVFKPAFSRLTQLFEATHDFSQVDWQLQKNDLDHFSLWQCHHQKEEIEHVAKSIRQKLYEGYRYKDILVLLGDMDAYQLQIGPIFDKFEIPYYLGKAEPMAAHPLVQFIESLERSQRYNWRREDILNMLKSGLFGCFDDSDIDRFEEYTQFADIKGFTKFSKPFTINSSRQYPLDFLNEMRQDIVLPLQELFKSQKQLGASLVDKLILFLKKIRLAENMQGLAQSQLEVEKNEEVWKRFTDILTSFHHIFGQEKLRLSDCLALIKTGMKSAQYRVVPATLDVVTIKSYDLVQPHSKPFVYAIGLTQSHFPKQIHHSGLLSDQERARINEIRNYRHFDIASAENSKKNHQTALSLFNAATKELVLSVPTVINETFDDLSPYLKELINFGLPLLDKGKNYLSYDNSDIGNYKALLSQIIAINRQDLIEMSDQDKMFWTVVLRYLRKQLRKQQLELPTSDYRLSTKSLSKEVIEVCFPKRIPLKLSATALTVFYNNQYNYFLKYVLNLNKTESIHPDSRIHGQYLHRVFERLMKDHTQEPFDNKLKQAIYHTNQESFFQQIYQDNAEAEYSLAILEDIVRSTAPILQLNQNIQVIDQEKNFHLDMGNEILVHGIIDRIDQLSDGSLGIVDYKSSANQFDIGTFYNGLSPQLVTYLAALKQITPHDINQLFGAMYLHLQDPKLDLVTFKQIDNTLVESIYKALTYKGIFSEVEKEHLSTGAYQTKNALYSNDELETLLNYNRYLYLKAAKHIKKGHFLINPYTSDGKTVQGDQLKAITRFEADLDMGQARRLVTLPAKEKKECFLTLMRKESHL
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The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity. ATP + H2O = ADP + H(+) + phosphate Heterodimer of AddA and RexB. Belongs to the helicase family. AddB/RexB type 2 subfamily.
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B2IPX4
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MKLLYTDIRTSLTEILTREAEELVAAGKRVFYIAPNSLSFEKERAVLECLSQQASFSITVTRFAQMARYLVLNDLPAKTILDDIGLGLAFYKCLAELNPKDLRVYGAIKQDPQLIQQLIELYHEMTKSQMNFLDLENLTDEDKRADLLLIFEKVTAYLNQGQLAQGSQLSHLIEAIENDKVSSDFNQIALVIDGFTRFSAEEERVVDLLHGKGVEIVIGAYASKKAYTSPFSEGNLYQASVKFLHHLASKYQTPAQDCSQTHEKMDSFDKASRLLESSYDFSELALDVDEKDRENLQIWSCLTQKEELELVARSIRQKLHENSDLSYKHFRILLGDVASYQLSLKTIFDQYQIPFYLGRSEAMAHHPLTQFVESILALKRYRFRQEDLINLLRTDLYTDLSQSDIDAFEQYIRYLGINGLPAFQQTFTKSHHGKFNLERLNVLRLRILAPLETLFASRKQKAENLLQKWSVFLKEGAVTKQLQDLTTTLEAVEQERQAEVWKAFCHVLEQFATVFAGSQVSLEDFLALLHSGMSLSQYRTIPATVDTVLVQSYDLIAPLTADFVYAIGLTQDNLPKISQNTSLLTDEERQNLNQATEEGVQLLIASSENLKKNRYTMLSLVNSARKQLFLSAPSLFNESESKESAYLQELIHFGFRRREKRMNHKGLSKEDMGSYHSLLSSLVAYHQQGEMSDTEQDLTFVKVLSRVIGKKLDQQGLENPAIPTSPSSKTLAKDTLQALYPAKQEFYLSTSGLTEFYRNEYSYFLRYVLGLQEELRLHPDARSHGNFLHRIFERALQLPNEDSFDQRLEQAIQETSQEREFEAIYQESLEAQFTKEVLLDVARTTGHILRHNPAIETIKEEANFGGKDQAFIQLDNGRSVFVRGKVDRIDRLKANGAIGVVDYKSSLTQFQFPHFFNGLNSQLPTYLAALKREGEQNFFGAMYLEMAEPVQSLMAVKSLAGAVVEASKSMKYQGLFLEKESSYLGEFYNKNKANQLTDEEFQLLLDYNAYLYKKAAEKILAGRFAINPYTENGRSIAPYVQQHQAITGFEANYHLGQARFLEKLDLADGKRLVGEKLKQAWLEKIREELNR
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The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity. ATP + H2O = ADP + H(+) + phosphate Heterodimer of AddA and RexB. Belongs to the helicase family. AddB/RexB type 2 subfamily.
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B5XKR3
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MKLIYTEMSYSMTEILVNEARKAADQGYRVFYIAPNSLSFEKEREVLTLLPERGTFSIIVTRFVQMSRYFTVESSPSKQHLDDTTLAMIFYRALMQLKPEDLPSYGRLQNNSVFIEQLVELYKELKNAQLSVHDLTGLDHPQKQEDLIKIIELAETIMIQQDYNQDSPLQSFARAIKLGLLNNQLSKTVVVIDGFSRFSAEEDYLLSLLNNNCQEVIIGSYVSQKAYQKSFIKGNIYEASLHFLQDLAQKYHIKPVFATSNQVFKPAFSRLTQLFEATHDFSQVDWQLQKNDLDHFSLWQCHHQKEEIEHVAKSIRQKLYEGYRYKDILVLLGDMDAYQLQIGPIFDKFEIPYYLGKAEPMAAHPLVQFIESLERSQRYNWRREDILNMLKSGLFGCFDDSDIDRFEEYTQFADIKGFTKFSKPFTINSSRQYPLDFLNEMRQDIVLPLQELFKSQKQLGASLVDKLILFLKKIRLAENMQGLAQSQLEVEKNEEVWKRFTDILTSFHHIFGQEKLRLSDCLALIKTGMKSAQYRVVPATLDVVTIKSYDLVQPHSKPFVYAIGLTQSHFPKQIHHSGLLSDQERARINEIRNYRHFDIASAENSKKNHQTALSLFNAATKELVLSVPTVINETFDDLSPYLKELINFGLPLLDKGKNYLSYDNSDIANYKALLSQIIAINRQDLIEMADQDKMFWTGVLRYLRKQLRKQQLELPTSDYRLSTKPLSKEVIEVCFPKGIPLKLSATALTVFYNNQYNYFLKYVLNLNKTESIHPDSRIHGQYLHRVFERLMKDHTQEPFDNKLKQAIYHTNQESFFQQVYQDNAEAEYSLAILEDIVRSTAPILQLNQNIQVIDQEKNFQLDMGNEILVHGIIDRIDQLSDGSLGIVDYKSSANQFDIGTFYNGLSPQLVTYLAALKQIAPHDINQLFGAMYLHLQDPKLDLVTFKQIDNTLVESIYKALTYKGIFSEVEKEHLSTGAYQTKNALYSNDELETLLNYNKYLYLKAAKHIKKGHFLINPYTSDGKTVQGDQLKAITRFEADLDMGQARRLVTLPAKEKKECFLTLMRKESHL
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The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity. ATP + H2O = ADP + H(+) + phosphate Heterodimer of AddA and RexB. Belongs to the helicase family. AddB/RexB type 2 subfamily.
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Q8DPR7
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MKLLYTDIRTSLTEILTREAEELVAAGKRVFYIAPNSLSFEKERAVLEYLSQQASFSITVTRFAQMARYLVLNDLPAKTTLDDIGLGLAFYKCLAELDPKDLRVYGAIKQDPQLIQQLIELYHEMTKSQMSFLDLENLTDEDKRADLLLIFEKVTAYLNQGQLAQESQLSHLIEAIENDKVSSDFNQIALVIDGFTRFSAEEERVVDLLHGKGVEIVIGAYASKKAYTSPFSEGNLYQASVKFLHHLASKYQTPAQDCSQTHEKMDSFDKASRLLESSYDFSELALDVDEKDRENLQIWSCLTQKEELELVARSIRQKLHENSDLSYKHFRILLGDVASYQLSLKTIFDQYQIPFYLGRSEAMAHHPLTQFVESILALKRYRFRQEDLINLLRTDLYTDLSQSDIDAFEQYIRYLGINGLPAFQQTFTKSHHGKFNLERLNVLRLRILAPLETLFASRKQKAEKLLQKWSVFLKEGAVTKQLQDLTTTLEAVEQERQAEVWKAFCHVLEQFATVFAGSQVSLEDFLALLHSGMSLSQYRTIPATVDTVLVQSYDLIAPLTADFVYAIGLTQDNLPKISQNTSLLTDEERQNLNQATEEGVQLLIASSENLKKNRYTMLSLVNSARKQLFLSAPSLFNESESKESAYLQELIHFGFRRREKRMNHKGLSKEDMGSYHSLLSSLVAYHQQGEMSDTEQDLTFVKVLSRVIGKKLDQQGLENPAIPTSPSSKTLAKDTLQALYPAKQEFYLSTSGLTEFYRNEYSYFLRYVLGLQEELRLHPDARSHGNFLHRIFERALQLPNEDSFDQRLEQAIQETSQEREFEAIYQESLEAQFTKEVLLDVARTTGHILRHNPAIETIKEEANFGGKDQAFIQLDNGRSVFVRGKVDRIDRLKANGAIGVVDYKSSLTQFQFPHFFNGLNSQLPTYLAALKREGEQNFFGAMYLEMAEPVQSLMAVKSLAGAVVEASKSMKYQGLFLEKESSYLGEFYNKNKANQLTDEEFQLLLDYNAYLYKKAAEKILAGRFAINPYTENGRSIAPYVQQHQAITGFEANYHLGQARFLEKLDLADGKRLVGEKLKQAWLEKIREELNR
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The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity. ATP + H2O = ADP + H(+) + phosphate Heterodimer of AddA and RexB. Belongs to the helicase family. AddB/RexB type 2 subfamily.
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A4W0M6
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MKLVYTDIRNPLTQYLTEQTATFAEQGKRVFYIAPNSLSFEMERKVLEYLPEQATFDIIVTRFGQLARYLMIDRKEAGQPLDDVGLAMIFFRVLSQFEDGDLKVYGRLQTDFGFINQLVALYKELQRANMSILDLEAMDSPDKQADLVKIFLAVTDILSKEGFEHQSKLAQLTGLVETGQLDEQLKNIVLVVDGFSRFSAEEEALVSALNERVSEILIGVYASKKAVQATYAEGNVYQANVDFLRQLSAQFQTKATYIGQEPVLDSIGKFSKNMEAYYDYSGTMIDLTPADQEKIQLWEVVNQKEEVEQVATAIRQHVHQGARYKDILLLLGDVDSYKLQIGKIFDKYDIPYYFGKAEEMSHHPLVHFVESLERLRRYRFRAEDLLNLLKSGLYASISQKELDLFESYILFADMKGQAAFSRAFSVNGRADYDAEVIKEKRLVYDLTVLEPLRAKIMEPLNQLFKAGPQSGTALLEKFMAFLEAIDLPKNMEKMSRNLSEVEQEKEEQVWKSFTHLLENFHQIFGKEKLKMDDFLAILQAGMQASHYRTVPATVDVVNVKSYDLIEPHTAKYVYAIGMGQSNFPKVAKNTSLLTEEEMEKVNLVSASSSRFDLVSRENIKKNHAAMMSLLNSATEQLVISTPQIYNEGEDSLSPYIKILQKMGLKSEERGRIKTLSPQDIGHYKSLLSRLIESERPSLETEEWEGQRAFWTVLVRHLKKKLESQSIEIPTITGDIASKQLSDETLAALYPEDKPLNLSASSLTNFYNNQYLYFVRNVLRLREQESIHPTAFQHGLFLHRIFERVVMDQSELDFDQKVDKAILRTRDEAEFAMFYNQDADARYTEEVLDKIARSSATILRDNDLVEIDGQEKSFRQDKALVFDLQNGKSVHVNGTIDRLDTLQINQAVGVVDYKSSDQSFSVGDFYNGLKPQLVTYLAALQELDETKDKPVFGAMYLHLQDPIIKLKDTKNLEQLEGAANTSLVYKGLFLKEESLGLNHFYQTRNQLYTEDEFAVLLNHNQELYKQAAMDILAGRFAINPYTKDGRSVAGEQLKAITGFEADRHMGMARRLVKEAKRQDWMERMKGGQD
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The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity. ATP + H2O = ADP + H(+) + phosphate Heterodimer of AddA and RexB. Belongs to the helicase family. AddB/RexB type 2 subfamily.
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C0MGY7
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MKLLYTEISYSMTEILVKEARAYADKGYRVFYIAPNSLSFEKERSVLALLPEQGSFAITVTRFEQMARYFTLAKAANRQALDDNGLAMIFYRVLMQLQEDELKVFHRLRTDQAFIAQLVELYKELQAANLTAFDLTTLDRPEKQEDLITIMTKAEQLIAQGDYDQSSRLAQLAEAIKSKSLDDELRQTVLVIDGFTRFSAEEEQLLALLNEACEEIVIGAYISQKAYRLAFTKGNLYEASLAFIQQLAQQFQTKPIYTTSEKVFDVSFSRLTQLLEANHDYSKLDWQLSAKDKSKVVIWQALNQKEELEYVAKAIREKLYQGYRYKDMLVLLGDVASYQLQIGPIFEKFEIPYYIGKQEPMSAHPLVQFVESLERGRRYNWRREDIVNLLKSGLFGRFQEGELDQLEQYLVFADIQGFTKFSRPFTLNSSRQYPLPLLNQLRLAVVTPLQQLFKSQKQLGASLLDKLMTFFKTIQLADNFEALAGSRREADREKDEEVWKAFTGILETFYQVFGQEKMTLADCLALIKMGMQTAHYRTVPATLDVVSIKSYDLVEPHSKPFVFAIGLSRSHFPKQTKNTSLISDQERASINEQTASYQRLDVPSFENIKKNHQTALSLFNAATQELVLSLPTSLTNSSDDVSPYLKELIALGVPVIEKGKNRLSHSAADIGNYKALLSRLVAINRQGIADDMTSEDRNFWTVALRYLKRRLADEQLSLPAFEHHLTTKPVAPEVIETRFPSHQPLSLSSSALTVFYNNQYKYFLKYVLGLQEPESIHPDARIHGQYLHRIFELVTKDRTDAAFDQKLGAAIAAVNQQSAFQQVYQADAEGRYSLEVLKGIAYSTAPVLNLNQGMQVAKQEEAFELALGHQALIRGVIDRIDQLADGRLGIVDYKSSARVFDIGAFYNGLSPQLVTYLAALKNKGQGLFGAMYLHMQEPRLSLSDFKVLDDQLVAAAYKELTYKGIFLAQAKEYLANGSYHLNNTLYETDELETLLAYNEQLYLSAVKQIKTGHFLINPYTADGKSVQGDQLKAITRFEADLDLGYARRLVVLPVKERRQAFLTRMNEEIKHED
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The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity. ATP + H2O = ADP + H(+) + phosphate Heterodimer of AddA and RexB. Belongs to the helicase family. AddB/RexB type 2 subfamily.
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A3CNU0
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MKLLYTDIRHSLTKVLVAEAESLVAAGKRVFYIAPNSLSFEKERSVLECLKTQASFAITVTRFAQMARYFVLNDVRQGQSLDDIGLGMLIYRTLTELDDGELKVYSRIKKDPQFIQQLMDLYHELQTAQMSFADLEFLEEPEKREDLVKIFTAVTAALNKGDFDSSSQIAAFAQHILAGDTDEELADLALVIDGFTRFSAEEEYLVGLLHRKGVEIVIGTYASQKAYRAAFREGNLYQASVDFLRKLAEDYQVKPDYIPHAEAEDAFGRISKILESRYDFSESTVSLSESDRSQLQIWATMNQKEELEYVAKSIRQRVHEGVRYKDIRLLLGDVEAYQLQLKTIFDQYQIPYYLGRSESMAQHPLVQFVESLERLKRYNFQLEDLLNLLKTGLYGDLTQEELDHFEQYLRFADIKGAGKLAKDFTANSQGKFDLDCLNHIRRRVMTPLQDFFKSRSQTASGLLAKFTEFVQAARLSDNLTALLQGESQQEQERHEEVWKAFSHVLEQFAQVFADSKVKLDDFLALVLSGMLLSNYRTVPATVDVVKVQSYDLIEPLAAPYVYAIGLTQERFPKIAQNKSLLSDEDRARLNDATDSQAELQIASSENLKKNRYTALSLMNSATKELVLSAPALVNEVEDSMSTYLLELTAAPLSLPIIVKKPQASSDDIGSYRALLSQIIELHQEEIDREWTAEEQTFWAVAVRVLRKKLAAEGISIPHISKELKTETLQSETLQALYPQEQPLRLSASALNEYFRHQYAYFLKYVLRLQEEWTIHPDARSHGIFLHRIFEKVLQDDSSADFDRRLAQAMEETSREAEFESIYSESGQTRFARQLLLDTARATGRVLAHPSGIETIGEETGFGSASTPFLTLENGRAVTVSGKVDRIDRLTKTESLGVVDYKSGDIKFSFEKFFNGLNSQLPTYLAAIEELADYQEDKGTFGAMYLQMTDPIVALKDTKTLADAVSQSMKPLQYKGLFVADAVKELGPLYEKNKTNLLSQEDLDLLLAYNAYLYKKAAEGILSGHFAVNPYTENGRSIAPYVEQFKAITGFEANLHLGQARQLEKLDASKFDRRPTGDKLRQAWLEKMREEMEK
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The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity. ATP + H2O = ADP + H(+) + phosphate Heterodimer of AddA and RexB. Belongs to the helicase family. AddB/RexB type 2 subfamily.
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A4VUD1
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MKLVYTDIRNPLTQYLTEQTATFAEQGKRVFYIAPNSLSFEMERKVLEYLPEQATFDIIVTRFGQLARYLMIDRKEAGQPLDDVGLAMIFFRVLSQFEDGDLKVYGRLQTDFGFINQLVALYKELQRANMSILDLEAMDSPDKQADLVKIFLAVTDILSKEGFEHQSKLAQLTGLVETGQLDEQLKNIVLVVDGFSRFSAEEEALVSALNERVSEILIGVYASKKAVQATYAEGNVYQANVDFLRQLSAQFQTKATYIGQEPVLDSIGKFSKNMEAYYDYSGTMIDLTPADQEKIQLWEVVNQKEEVEQVATAIRQHVHQGARYKDILLLLGDVDSYKLQIGKIFDKYDIPYYFGKAEEMSHHPLVHFVESLERLRRYRFRAEDLLNLLKSGLYASISQKELDLFESYILFADMKGQAAFSRAFSVNGRADYDAEVIKEKRLVYDLTVLEPLRAKIMEPLNQLFKAGPQSGTALLEKFMAFLEAIDLPKNMEKMSRNLSEVEQEKEEQVWKSFTHLLENFHQIFGKEKLKMDDFLAILQAGMQASHYRTVPATVDVVNVKSYDLIEPHTAKYVYAIGMGQSNFPKVAKNTSLLTEEEMEKVNLVSASSSRFDLVSRENIKKNHAAMMSLLNSATEQLVISTPQIYNEGEDSLSPYIKILQKMGLKSEERGRIKTLSPQDIGHYKSLLSRLIESERPSLETEEWEGQRAFWTVLVRHLKKKLESQSIEIPTITGDIASKQLSDETLAALYPEDKPLNLSASSLTNFYNNQYLYFVRNVLRLREQESIHPTAFQHGLFLHRIFERVVMDQSELDFDQKVDKAILRTRDEAEFAMFYNQDADARYTEEVLDKIARSSATILRDNDLVEIDGQEKSFRQDKALVFDLQNGKSVHVNGTIDRLDTLQINQAVGVVDYKSSDQSFSVGDFYNGLKPQLVTYLAALQELDETKDKPVFGAMYLHLQDPIIKLKDTKNLEQLEGAANTSLVYKGLFLKEESLGLNHFYQTRNQLYTEDEFAVLLNHNQELYKQAAMDILAGRFAINPYTKDGRSVAGEQLKAITGFEADRHMGMARRLVKEAKRQDWMERMKGGQD
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The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity. ATP + H2O = ADP + H(+) + phosphate Heterodimer of AddA and RexB. Belongs to the helicase family. AddB/RexB type 2 subfamily.
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Q5LY79
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MKLLYTDMSQDLTEILTEQASSYAQKGKRVFYIAPSALSFEKERKVLEYLPQSASFDITVTRFTQMARYFILNTSNPKTQLDDTGLAMIFYKVLLHMGDDELKVYGRLRKDSNFINQLVDLYKELQQANMTVLDLQHLDQVEKQEDLVRIFSAAQDLLLAGDFDNQSKLSAFFKEITSGHLDEALSNTVLVIDGFTRFSAEEEALVALLNDKCHQIVVGTYTSQKAYKANFVYGNAYQASVDFLRTLAQTYKVIPDYVTTDKEGNLSFARISRLLESRHDFSTVDETVTEQDKHALKVWEVVNQKEEVAQVAKSIRQLLADGKRYKDILVLLGDEESYKLHVGQIFRKFDIPYYFGKEESMSSHPLVEFVDSLERIKRYNYRAEDLLNLVKSGLYGGFAQEDLDLFEYYVNFADIKGRHKFLSDFTANSRDKYNLDQINALRSQLIEPLDKFLNSRKQKGSSLLKKLVVFLEAVQLPSQMFELSTKASEAEKEQNEQVWKAFTHILEQVETIFGDESLSVDDFLSILRSGMLACDYRTVPATVDVVNVKKYDLIQPHSAPYVFALGMTQSHFPKVGQNKSLLSDEERSRINEATDEHRRLDIVTQINSKRGHFVAMSLFNAASEQLVLSQPQIINESQDDMSVYLKELLDLGIPLVEKGRNRFEAKGDQIGNYRDLLSTVIALNSSHLDLDLDKETQTFWSVAVRYLRKRLDKDQVLIPKVIDDVTTTKVDDQVMQLVFPEEEPLKLSATALTTFYNNQYLYFLRYVLELEELESIHPDARHHGTYLHRVFERVMGDSSSESFDDKLEKAIAQTNQDQPFEILYTEDQESRFSRQILEDIARSTASVLRDNAAVKVECEEVKFDLLLANSIKITGIIDRVDRLTDGALGVVDYKTGKNVFDIQKFYNGLSPQLVTYLEALRQTYKVDADQLFGAMYLHMQVPQLNLSQIGLEKLAAQAHKELTYKGLFVASETEHLTGGNYDLQKTVTYDKEDLETLLDYNIKLFRSAAEVIRSGNFAINPYTEDGKSVQGDQIKSITHFEADRHMGQARKLLRLPKKGKKEAYLELMAKTEEENQMQVSENTISFPVIDHAVRVDKKDQEDNHVD
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The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity. ATP + H2O = ADP + H(+) + phosphate Heterodimer of AddA and RexB. Belongs to the helicase family. AddB/RexB type 2 subfamily.
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Q5M2T6
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MKLLYTDMSQDLTEILTEQASSYAQKGKRVFYIAPSALSFEKERKVLEYLPQSASFDITVTRFTQMARYFILNTSNPKTQLDDTGLAMIFYKVLLHMGDDELKVYGRLRKDSNFINQLVDLYKELQQANMTVLDLQHLDQVEKQEDLVRIFSAAQDLLLAGDFDNQSKLSAFFKEITSGHLDEALSNTVLVIDGFTRFSAEEEALVALLNDKCHQIVVGTYTSQKAYKANFVYGNVYQASVDFLRTLAQTYKVIPDYVTTDKEGNLSFARISRLLESRHDFSTVDETVTEQDKHALKVWEVVNQKEEVAQVAKSIRQLLADGKRYKDILVLLGDEESYKLHVGQIFRKFDIPYYFGKEESMSSHPLVEFVDSLERIKRYNYRAEDLLNLVKSGLYGGFAQEDLDLFEYYVNFADIKGRHKFLSDFTANSRDKYNLDQINALRSQLIEPLDKFLNSRKQKGSSLLKKLVVFLEAVQLPSQMFELSTKASEAEKEQNEQVWKAFTHILEQVETIFGDESLSVDDFLSILRSGMLACDYRTVPATVDVVNVKKYDLIQPHSAPYVFALGMTQSHFPKVGQNKSLLSDEERSRINEATDEHRRLDIVTQINSKRGHFVAMSLFNAASEQLVLSQPQIINESQDDMSVYLKELLDLGIPLVEKGRNRFEAKGDQIGNYRDLLSTVIALNSSHLDLDLDKETQTFWSVAVRYLRKRLDKDQVLIPKVIDDVTTTKVDDQVMQLVFPEEEPLKLSATALTTFYNNQYLYFLRYVLELEELESIHPDARHHGTYLHRVFERVMGDSSSESFDDKLEKAIAQTNQDQPFEILYTEDQESRFSRQILEDIARSTASVLRDNAAVKVECEEVKFDLLLANSIKITGIIDRVDRLTDGALGVVDYKTGKNVFDIQKFYNGLSPQLVTYLEALRQTYKVDADQLFGAMYLHMQVPQLNLSQIGLEKLAAQAHKELTYKGLFVASETEHLTGGNYDLQKTVTYDKEDLETLLDYNIKLFRSAAEVIRSGNFAINPYTEDGKSVQGDQIKSITHFEADRHMGQARKLLRLPKKGKKEAYLELMAKTEEENQMQVSENTISFPVIDHAVRVDKKDQEDNHVD
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The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity. ATP + H2O = ADP + H(+) + phosphate Heterodimer of AddA and RexB. Belongs to the helicase family. AddB/RexB type 2 subfamily.
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Q03IZ7
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MKLLYTDMSQDLTEILTEQASSYAQKGKRVFYIAPSALSFEKERKVLEYLPQSASFDITVTRFTQMARYFILNTSNPKTQLDDTGLAMIFYKVLLHMGDDELKVYGRLRKDSNFINQLVDLYKELQQANMTVLDLQHLNQVEKQEDLVRIFSAAQDLLLAGDFDNQSKLSAFFKEITSGHLDEALSNTVLVIDGFTRFSAEEEALVALLNDKCHQIVVGTYTSQKAYKANFVYGNVYQASVDFLRTLAQTYKVIPDYVTTDKEGNRSFARISRLLESRHDFSTVDETVTEQDKHALKVWEVVNQKEEVAQVAKSIRQLLADGKRYKDILVLLGDEESYKLHVGQIFRKFDIPYYFGKEESMSSHPLVEFVDSLERIKRYNYRAEDLLNLVKSGLYGGFAQEDLDLFEYYVNFADIKGRHKFLSDFTANSRDKYNLDQINALRSQLIEPLDKFLNSRKQKGSSLLKKLVVFLEAVQLPSQMFELSTKASEAEKEQNEQVWKAFTHILEQVETIFGDESLSVDDFLSILRSGMLACDYRTVPATVDVVNVKKYDLIQPHSAPYVFALGMTQSHFPKVGQNKSLLSDEERSRINEATDEHRRLDIVTQINSKRGHFVAMSLFNAASEQLVLSQPQIINESQDDMSVYLKELLDLGIPLVEKGRNRFEAKGDQIGNYRDLLSTVIALNSSHLDLDLDKETQTFWSVAVRYLRKRLDKDQVLIPKVIDDVTTTKVDDQVMQLVFPEEEPLKLSATALTTFYNNQYLYFLRYVLELEELESIHPDARHHGTYLHRVFERVMGDSSSESFDDKLEKAIAQTNQDQPFEILYTEDQESRFSRQILEDIARSTASVLRDNAAVKVEREEVKFDLLLANSIKITGIIDRVDRLTDGALGVVDYKTGKNVFDIQKFYNGLSPQLVTYLEALRQTYKVDADQLFGAMYLHMQVPQLNLAQIGLEKLAAQAHKELTYKGLFVSSETEHLTGGNYDLQKTVTYDKEDLETLLDYNIKLFRSAAEVIRSGNFAINPYTEDGKSVQGDQIKSITHFEADRHMGQARKLLRLPKKGKKEAYLELMAKTEEENQMQVSENTISFPVIDHAVRVDKKDQEDNHVD
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The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity. ATP + H2O = ADP + H(+) + phosphate Heterodimer of AddA and RexB. Belongs to the helicase family. AddB/RexB type 2 subfamily.
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B9DRU9
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MKLLYTDIENSLTEILVQEAEVFANSGARVFYIAPNSLSFEKERTVLEHLTKESSFSITVTRFAQMARYFTLNKQKAQKSLDDLSLTMLFHLVLHDLSQNELTIYHALKSDQTFIKQLVDLFKEMQSANLTIADIEMENLARKEDLITIFSALSRELLRYDFQQMSSLAVFQEAIRSGLLDQELAKTVVIIDGFTRFSAEEESLIHQLHQKCQEIVIGTYISSKAMKQNFTKGNLYEASIDFLRQLSVTYQVKSLYLSGEKTFKNSFTTMSRLLESQYDYSLTELTISEDIKNDVQIWQQLNQKEEIENIARDIRQKLNEGYRYKDILVLLGDVEAYQLQVGPIFDKYDIPYYLGKAESMSHHPLVQFMDSLENCRRYNWRKEDIINLLKSRMLGDFTIRECDQFESYLNYADINGFTAFSKDFTANTFNQKNEKGYDLDKINLIRKYLFSHLNQFFKSRAQKGSNILNHFLQFLSDIDFVSSFQRLSQKQSALQQEKDEEVWKSFTSILESFYNIFKDETLTQELTLMLIKSAMQAADYRVVPATLDVVSVKSYDLVEPHSKSLVYALGLTRTHFPKTVQQTGLISDQERAKTNEKWDSHHRFDISSIENSKKNHYTALSLFNAATDKLVLSYPMVLNEVVEEASPYLKLLHSFGIPIVEKQKNTFSDLENGIGNYKSLLSQWIALNQEPLTEELYQEEKSFWLVMSRYLKKQLAAKKLTFPEQKSHLATSRLSPEVLAIKYPDHQPLSLSSSALTVYHDNQYKYFLQYVLGLQELESIHPDARHHGTYLHRVFEYVVDDQRSIPFDDKIEEAIQRTNQERLFQTYYQSDAESRFSLSLLEDIAKSTASIFPITPTKVLSQEERFQLHFDEKVRVNGIIDRIDQLDDGSIGIVDYKSSQTVFDIGKFYNGLNSQLPTYLEALNTREKSKDMPPQLFGAMYLHMQDPKMDLNEFKLFDDKVVEKLYSRLTYKGIFLEREKEHLASGAYQMKSNLYSEEELRNLLDYNQFLYLKAEKEIRAGHFLINPYTEDGKTVKGDQLKAITRFEADLDLGQARMLLKLPTKEKREGFLKLMKEDMKGGKKDEI
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The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity. ATP + H2O = ADP + H(+) + phosphate Heterodimer of AddA and RexB. Belongs to the helicase family. AddB/RexB type 2 subfamily.
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Q67MD4
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MRFIIGGAGSGKSQRCLDELTQAAQAAPAGPPLILLVPEQATFQVEQALLGSGRLKGIIRAQVLSFQRLAWRVSLKAGGLALPPLSDLGKQMVLRALLEKKRDDLRLFHQVADKPGFIERVAGSIRELRSYRQGPESLRRQLSQLEAEGLGETSLGAKLHDLALVMDELRSYIEGRFTDPDEYLTVLAARLEESRLLEGAEVWVDGFNGFTPQELAVLGAVMRSARQVHISLCIPPGQLYKAGGHHSPSDLFHPVLSTYDQLMQLAAESGVAVDPPLYLNEPLRFRGAPELAHVERYLFRQSAPAWPGAPERIALVEAQNRREEVAAAAREILRLVREEGLRFREIAVVARDLEGYGDLAATLFAEHGIPAFIDRRRTVAHHPLVELLRAALEVVVQDWAYGPVFRYLKTDLTGVSRAEIDLLENYVIEHGIRGRAWQQQEPWQYLRRYTLEEDAVPAGPAQQALLDEIHRIRRRATAPLLAFQRRLQRRGRPGPTVREITTYLFQLLDDLKVARQLEAWKAEAEQRGDLETAREHEQVWTRVLELFDQIVEGLGDQVLSPKVYLQVLSAGLDGLKLGLIPPGLDQVIVGTVERSRHAGVRATLILGATEKDFPPQPAEDAIFTDRERERLKQSGLDVGPTSLERLFQEQFLTYVALTRGSDFLWISYPLADESGRAAAPSPVVGRMRRLFPELKPRPAAPPAPDAEAAVAQVATPRQLAAAVARALRRARSGYAVEPHWLDLYQCIVLDPDLHREGAAVLAAVGYEEWLRRRGTPVGRELARLLYGDRLVTSVSRLEAFLSCPFRHFAGYALRLQGRAEFTVSAPEFGLFYHAALSLFVRELERDGLAWDTLTPDEAWRRMDSIIDRLAPRLQSEILLSSPQHRYLLRVIRRTLQSSLDYLSEHVLHGEFRPVAVEVPFGEEMDGLPPVEVDLPGGGRVLLRGRIDRVDALEGRDGRWYVRVIDYKSGRRDLRLGDFYHGLTLQLLLYLMAVVEGGEPLLPGTRVPAGALYLPVYDPVEPVNAPVPPDEVRPLRRKRYQARGLVSDDPAVIQAMDAAGLGLIQAKLKKDGTVYKGAPVASPDQFRQLFAHLRRVVRACGEQILQGEAAIAPYRLGPHTACQYCAYRPVCQFDPAVEPQGYRRLEKMDAPDVWQRVAAAGGEGDV
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The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddB nuclease domain is not required for chi fragment generation; this subunit has 5' -> 3' nuclease activity. ATP + H2O = ADP + H(+) + phosphate Binds 1 [4Fe-4S] cluster. Heterodimer of AddA and AddB. Belongs to the helicase family. AddB/RexB type 1 subfamily.
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B0KDB8
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MGIRFIYGRAGTGKTYFCLREIKEKINDGNSHPLILLVPEQFTFEAEKYLLETVEKDRKMRAQVLSFKTLANRVFTEVGGLTRQHVNSCGRSMVIYKIMEDLKENLKVYYKASRQQGFIKKISEVITEFKRFEVTPEKLMDTAESIQKEGLREKLRELSLIYGKFDELLHQKYIDEEDALTLLAEKLEYSEQFKGAEFWIDGFTGFTPKQYKVLEKLLKKAARVSVTLTMDTSKDSIDNTDLFYTTKKTEDKLLKICYENNISYEKPVDLNEGVPKRFEKNEEMAFLEKHLFSYPYKIYSKDTKNISLFKAVNVYSEVEETAREIIRLVRDENLRYSDIVVTARDLKRYHKLIKTIFSHYGIPHFIDLKLDIKNNPIIVYITSLFEIYLKNWSYESVFRHLKTGFTNLNKEDISFLENYVLANGIKGGKWKEEWKYSFRNRLDKLFDDQDEKEALEKVNTIKNGISEPLNKFYKDFSNANTVREACEILYNFLVERDIPQRIENLIREFKENKEFEIANQYSQIWDIVVDVLDQMVEVMGEEKINIDLFSKILDIGFEAYQIGSIPPALDEVLVTSVDRMKSHNAKALFVIGANDGIFPASSFEEGILTDEDRQILTSYEVELDRDTKAKVFEEQFLVYTALTSTSKFLRISYPIADHEGRSLRPSIIISRFKRIFPQITQFSNVIEMDTDEENLHRVSSPDPTFNEMIKSFKEWDIKDKINSLWLDVYNWYSNKEVWRKRIEKVLEGFNYSNQVRVIPSAKIKRLYKDEINFSVSRLEKYAACPFAYFVQYGLKAKERKIYSFDPPDLGIFMHNVLNEVSKALEKEDKTWEDLDREYCDEVVNIVVDNMLKGVSEHILKSSPRYEYLSKRLTRVLSNAVWVISEHIKRSSFIPSGHEVAFGENQMYPPIKIILSNGEEINLIGRIDRVDVFEKGEESYIRIIDYKSGNKELKLEDVFYGLELQLLIYLDAILESADKENTDIKPAGIFYFRIDDPIVKADKDITDEELQKEILKKLRLDGLVLKDAEIIKEMDKSINGTSYIIPASINKDGTIGKKTKGATKEQFELLRKHVKNMIKDLAEQMINGNISITPYRKGKETACKYCPYSSVCKFETNFEGNKYMFIKEQKEEEIWNMLQKEVNKDGDKVD
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The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddB nuclease domain is not required for chi fragment generation; this subunit has 5' -> 3' nuclease activity. ATP + H2O = ADP + H(+) + phosphate Binds 1 [4Fe-4S] cluster. Heterodimer of AddA and AddB. Belongs to the helicase family. AddB/RexB type 1 subfamily.
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B0K212
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MGIRFIYGRAGTGKTYFCLREIKEKINDGNSHPLILLVPEQFTFEAEKYLLETVEKDRKMRAQVLSFKTLANRVFTEVGGLTRQHVNSCGRSMVIYKIMEDLKENLKVYYKASRQQGFIKKISEVITEFKRFEVTPEKLMDTAESIQKEGLREKLRELSLIYGKFDELLHQKYIDEEDALTLLAEKLEYSEQFKGAEFWIDGFTGFTPKQYKVLEKLLKKAARVSVTLTMDTSKDSIDNTDLFYTTKKTEDKLLKICYENNISYEKPVDLNEGVPKRFEKNEEMAFLEKHLFSYPYKIYSKDTKNISLFKAVNVYSEVEETAREIIRLVRDENLRYSDIVVTARDLKRYHKLIKTIFSHYGIPHFIDLKLDIKNNPIIVYITSLFEIYLKNWSYESVFRHLKTGFTNLNKEDISFLENYVLANGIKGGKWKEEWKYSFRNRLDKLFDDQDEKEALEKVNTIKNGISEPLNKFYKDFSNANTVREACEILYNFLVERDIPQRIENLIREFKENKEFEIANQYSQIWDIVVDVLDQMVEVMGEEKINIDLFSKILDIGFEAYQIGSIPPALDEVLVTSVDRMKSHNAKALFVIGANDGIFPASSFEEGILTDEDRQILTSYEVELDRDTKAKVFEEQFLVYTALTSTSKFLRISYPIADHEGRSLRPSIIISRFKRIFPQITQFSNVIEMDTDEENLHRVSSPDPTFNEMIKSFKEWDIKDKINSLWLDVYNWYSNKEVWRKRIEKVLEGFNYSNQVRVIPSAKIKRLYKDEINFSVSRLEKYAACPFAYFVQYGLKAKERKIYSFDPPDLGIFMHNVLNEVSKALEKEDKTWEDLDREYCDEVVNIVVDNMLKGVSEHILKSSPRYEYLSKRLTRVLSNAVWVISEHIKRSSFIPSGHEVAFGENQMYPPIKIILSNGEEINLIGRIDRVDVFEKGEESYIRIIDYKSGNKELKLEDVFYGLELQLLIYLDAILESADKENTDIKPAGIFYFRIDDPIVKADKDITDEELQKEILKKLRLDGLVLKDAEIIKEMDKSINGTSYIIPASINKDGTIGKKTKGATKEQFELLRKHVKNMIKDLAEQMINGNISITPYRKGKETACKYCPYSSVCKFETNFEGNKYMFIKEQKEEEIWNMLQKEVNKDGDKVD
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The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddB nuclease domain is not required for chi fragment generation; this subunit has 5' -> 3' nuclease activity. ATP + H2O = ADP + H(+) + phosphate Binds 1 [4Fe-4S] cluster. Heterodimer of AddA and AddB. Belongs to the helicase family. AddB/RexB type 1 subfamily.
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B5RAJ6
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MIDITLPLTDIHRHLDGNIRAQTILDLGRQFNIALPAQTLETLIPHVQVTSTEPDLVSFLTKLDWGVKVLASLDACRRVAFENIEDAARNGLHYVELRFSPGYMAMAHQLPIAGVVEAVIDGVRDGCNTFGVEARLIGIMSRTFGEAACLQELDALLAHRENITALDLAGDELGFPGSLFLSHFNRARDAGWHITVHAGEAAGPESIWQAIRELGAERIGHGVKAVEDRALMDFLVQQRIGIESCLTSNIQTSTIASLADHPLKTFLEHGVLASLNTDDPAVQGVDIIHEYHVAAPAAGLSREQIRQAQINGLEIAFLSDGEKRALREKVAAA
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Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. adenosine + H(+) + H2O = inosine + NH4(+) 2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+) Binds 1 zinc ion per subunit. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
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B4THP5
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MIDITLPLTDIHRHLDGNIRAQTILDLGRQFNIALPAQTLETLIPHVQVTSTEPDLVSFLTKLDWGVKVLASLDACRRVAFENIEDAARNGLHYVELRFSPGYMAMAHQLPIAGVVEAVIDGVRDGCNTFGVEARLIGIMSRTFGEAACLQELDALLAHREKITALDLAGDELGFPGSLFLSHFNRARDAGWHITVHAGEAAGPESIWQAIRELGAERIGHGVKAVEDRALMDFLAQQRIGIESCLTSNIQTSTVASLADHPLKTFLEHGVLASLNTDDPAVQGVDIIHEYHVAAPAAGLSREQIRQAQINGLEIAFLSDGEKRALREKVAAA
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Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. adenosine + H(+) + H2O = inosine + NH4(+) 2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+) Binds 1 zinc ion per subunit. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
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B4T5A0
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MIDITLPLTDIHRHLDGNIRAQTILDLGRQFNIALPAQTLETLIPHVQVTSTEPDLVSFLTKLDWGVKVLASLDACRRVAFENIEDAARNGLHYVELRFSPGYMAMAHQLPIAGVVEAVIDGVRDGCNTFGVEARLIGIMSRTFGEAACLQELDALLAHRENITALDLAGDELGFPGSLFLSHFNRARDAGWHITVHAGEAAGPESIWQAIRELGAERIGHGVKAVEDRALMDFLVQQRIGIESCLTSNIQTSTVASLADHPLKTFLEHGVLASLNTDDPAVQGVDIIHEYHVAAPAAGLSREQIRQAQINGLEIAFLSDGEKRALREKVAAA
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Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. adenosine + H(+) + H2O = inosine + NH4(+) 2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+) Binds 1 zinc ion per subunit. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
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C0Q502
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MIDITLPLTDIHRHLDGNIRAQTILDLGRQFNIALPAKTLEALIPHVQVTSTEPDLVSFLTKLDWGVKVLASLDACRRVAFENIEDAARNGLHYVELRFSPGYMAMAHQLPIAGVVEAVIDGVRDGCNTFGVEARLIGIMSRTFGEAACLQELDALLAHREKITALDLAGDELGFPGSLFLSHFNRARDAGWHITVHAGEAAGPESIWQAIRELGAERIGHGVKAVEDRALMDFLAQQRIGIESCLTSNIQTSTVASLADHPLKTFLEHGVLASLNTDDPAVQGVDIIHEYHVAAPAAGLSREQIRQAQINGLEIAFLSDGEKRALREKVAAA
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Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. adenosine + H(+) + H2O = inosine + NH4(+) 2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+) Binds 1 zinc ion per subunit. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
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B4TVC7
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MIDITLPLTDIHRHLDGNIRAQTILDLGRQFNIALPAQTLETLIPHVQVTSTEPDLVSFLTKLDWGVKVLASLDACRRVAFENIEDAARNGLHYVELRFSPGYMAMAHQLPIAGVVEAVIDGVRDGCNTFGVEARLIGIMSRTFGEAACLQELDALLAHREKITALDLAGDELGFPGSLFLSHFNRARDAGWHITVHAGEAAGPESIWQAIRELGAERIGHGVKAVEDRALMDFLAQQRIGIESCLTSNIQTSTVASLADHPLKTFLEHGVLASLNTDDPAVQGVDIIHEYHVAAPAAGLSREQIRQAQINGLEIAFLSDDEKRALREKVAAA
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Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. adenosine + H(+) + H2O = inosine + NH4(+) 2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+) Binds 1 zinc ion per subunit. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
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Q8Z6R2
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MIDITLPLTDIHRHLDGNIRAQTILDLGRQFNIALPAQTLETLIPHVQVTSTEPDLVSFLTKLDWGVKVLASLDACRRVAFENIEDAARNGLHYVELRFSPGYMAMAHQLPIAGVVEAVIDGVRDGCNTFGVEARLIGIMSRTFGEAACLQELDALLAHREKITALDLAGDELGFPGSLFLSHFNRARDAGWHITVHAGEAAGPESIWQAIRELGAERIGHGVKAVEDRALMDFLAQQRIGIESCLTSNIQTSTVASLADHPLKTFLEHGVLASLNTDDPAVQGVDIIHEYHVAAPAAGLSREQIRQAQINGLEIAFLSDSEKRALREKVAAA
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Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. adenosine + H(+) + H2O = inosine + NH4(+) 2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+) Binds 1 zinc ion per subunit. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
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Q8ZPL9
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MIDITLPLTDIHRHLDGNIRAQTILDLGRQFNIALPAQTLETLIPHVQVTSTEPDLVSFLTKLDWGVKVLASLDACRRVAFENIEDAARNGLHYVELRFSPGYMAMAHQLPIAGVVEAVIDGVRDGCNTFGVEARLIGIMSRTFGEAACLQELDALLAHRENITALDLAGDELGFPGSLFLSHFNRARDAGWHITVHAGEAAGPESIWQAIRELGAERIGHGVKAVEDRALMDFLAQQRIGIESCLTSNIQTSTVASLADHPLKTFLEHGVLASLNTDDPAVQGVDIIHEYHVAAPAAGLSREQIRQAQINGLEIAFLSDSEKRALREKVAEA
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Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. adenosine + H(+) + H2O = inosine + NH4(+) 2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+) Binds 1 zinc ion per subunit. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
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A8GE12
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MIDSRLPLTDIHRHLDGNIRAQTILDLGRQFNLALPADELEALRPHVQITHAEPDLVSFLQKLDWGVAVLGDLEACRRVAYENVEDAANAGLHYAELRFSPYYMAMKHQLPVTGVVEAVIDGIRSGSRDLGIDVRLIGIMSRTFGEAACLQELEGLLAHRDGITALDLAGDELGFPGGLFLNHFNRARDAGLRITVHAGEAAGPESIWQAIRELGAERIGHGVKAVEDPALMDFLAEHGIGIESCLTSNIQTSTVASLAQHPLAKFLRHGVMASINTDDPAVQGIEIEHEYLVAAPQAGLTPAEIRTAQENGLKMAFLSEQEKQTLRDKVRG
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Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. adenosine + H(+) + H2O = inosine + NH4(+) 2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+) Binds 1 zinc ion per subunit. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
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A1S1P1
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MIDNKIPLVDLHRHLDGNVRVQTIWELGHQHGIALPADSLETLAPFVQIQGKETSLVAFLKKLDWMVAVLADLDAVQRVARENVADAALSGLDYAELRFSPYYMAMNHKLPIEGVVEAVIDGVNQGLKAHPQVKINLIGIMSRSFGVDACTAELNGLLAHRDKLVAIDLAGDELGFPGSLFNDHFKRVRDSGLNITVHAGEAAGAESMWQAIQELGATRIGHGVKAVQDPKLMEYLAKHRIGIESCPTSNLQTSTVKSLAEHPLRTFVDAGVLVCLNTDDPGVSNIDIKHEYRLAHNEMGFSAAELAKLQANGVEMAFISDSDRKALYAAKA
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Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. adenosine + H(+) + H2O = inosine + NH4(+) 2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+) Binds 1 zinc ion per subunit. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
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B8EDT7
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MIDTSIPLVDLHRHLDGNVRVNTIWELGHQHGIALPADSLETLAPFVQIQGKETSLVAFLKKLDWMVGVLADLDAVKRVAYENVADAALSGLDYAELRFSPYYMAMNHKLPIEGVVEAVVDGVKAGLKDYNVKINLIGILSRSFGQAACTQELEGLLAHKQHLVAMDLAGDEMGFPGELFNDHFKRVRDADLAITAHAGEAAGSQSMWQAIQELGATRIGHGVNAIHDPKLMEYLAKHRIGIESCPTSNLHTSTVASYAEHPFRTFMDAGVLINLNTDDPGVSAIDINHEYRIAKAELKLTDAELAQVQRNGVEMAFLSDSDRKALYAAKV
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Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. adenosine + H(+) + H2O = inosine + NH4(+) 2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+) Binds 1 zinc ion per subunit. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
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A3CYL9
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MIDTSIPLVDLHRHLDGNVRVNTIWELGHQHGIALPADSLETLAPFVQIQGKETSLVAFLKKLDWMVGVLADLDAVKRVAYENVADAALSGLDYAELRFSPYYMAMNHKLPIEGVVEAVVDGVKAGLKDYNVKINLIGILSRSFGQAACTQELEGLLAHKQHLVAMDLAGDEMGFPGELFNEHFKRVRDADLAITAHAGEAAGSQSMWQAIQELGATRIGHGVNAIHDPKLMEYLAKHRIGIESCPTSNLHTSTVASYADHPFRTFMDAGVLINLNTDDPGVSAIDINHEYRIAKSELKLTDAELAQVQRNGVEMAFLSDSERKALYAAKV
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Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. adenosine + H(+) + H2O = inosine + NH4(+) 2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+) Binds 1 zinc ion per subunit. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
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A6WUH7
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MIDTSIPLVDLHRHLDGNVRVNTIWELGHQHGIALPADSLETLAPFVQIQGKETSLVAFLKKLDWMVAVLADLDAVKRVAYENVADAALSGLDYAELRFSPYYMAMNHKLPIEGVVEAVVDGVKAGLKDYNVKINLIGILSRSFGQAACTQELEGLLAHKQHLVAMDLAGDEMGFPGELFNDHFKRVRDADLAITAHAGEAAGSQSMWQAIQELGATRIGHGVNAIHDPKLMEYLAKHRIGIESCPTSNLHTSTVASYAEHPFRTFMDAGVLINLNTDDPGVSAIDINHEYRIAKSELKLTDAELAQVQRNGVEMAFLSDSERKALYAAKV
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Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. adenosine + H(+) + H2O = inosine + NH4(+) 2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+) Binds 1 zinc ion per subunit. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
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A9KWZ3
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MIDTSIPLVDLHRHLDGNVRVNTIWELGHQHGIALPADSLETLAPFVQIQGKETSLVAFLKKLDWMVGVLADLDAVKRVAYENVADAALSGLDYAELRFSPYYMAMNHKLPIEGVVEAVVDGVKAGLKDYNVKINLIGILSRSFGQAACTQELEGLLTHKQHLVAMDLAGDEMGFPGELFNEHFKRVRDADLAITAHAGEAAGSQSMWQAIQELGATRIGHGVNAIHDPKLMEYLAKHRIGIESCPTSNLHTSTVASYADHPFRTFMDAGVLINLNTDDPGVSAIDINHEYRIAKSELKLTDAELAQVQRNGVEMAFLSDSERKALYAAKV
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Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. adenosine + H(+) + H2O = inosine + NH4(+) 2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+) Binds 1 zinc ion per subunit. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
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Q12I24
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MIDKSIPLVDLHRHLDGNVRVQTIWELGHQHGIALPAQSLAELAPFVQIQGKENSLVAFLKKLDWMVAVLADLDAVKRVAYENVADAALSGLDYAELRFSPYYMAMNHNLPIEGVVEAVIDGVNAGLKDHAVKINLIGIMSRSFGQEKCLLELEGLLAHKDKLVAMDLAGDELGFPGDLFNDHFKRVRDAGLAITAHAGEAAGSESMWQAIQTLGATRIGHGVNAIHDPKLMEYLVKHKIGIESCPTSNLHTSTVDNYDVHPLRTFLDAGVLIGLNTDDPGVSNIDIAHEYRVVKSEMGFSDAQLAQLQRNGVEMAFMSDSDRKALYAAKA
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Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. adenosine + H(+) + H2O = inosine + NH4(+) 2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+) Binds 1 zinc ion per subunit. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
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Q08A11
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MIDKTIPLVDLHRHLDGNVNVKTIWELGHQHGIQLPANSLEELAPFVQIQGKENNLVDFLKKLDWMVAVLADLDAVKRVAYENVIDAASQGLDYAELRFSPYYMAMNHNLPIEGVVEAVIDGVRAGVKEHDISVNLIGIMSRSFGQEKCRLELEGILAHRDSIVAMDLAGDELGFPGDLFTEHFKRVRDAGLQVTAHAGEAAGAESMWQAINILGATRIGHGVNAIHDPKLMEYLAKHRIGIESCPTSNLHTSTVKDYDVHPLRKFMDAGVLIGLNTDDPGVSAIDIAHEYRVVKSEMGFSDSQLATLQRNGVEMAFMSDSDRKALYAKKAK
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Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. adenosine + H(+) + H2O = inosine + NH4(+) 2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+) Binds 1 zinc ion per subunit. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
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B0TT81
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MNYLQLPKIDLHCHLDGSVRPQTVIDLAKIQGIDIPSDNVDDIKSLMVAPESCPNLDEYLTRFALPVSVMQTEAALERVSFELFEDAAKENVKYLEVRFGPQLHRKQGLNFEQIIGSVVKGMHRAEALYDIKGNYILSIIKVLPKDDINEVIDAGATFLNKGVVAFDLAASEEPGFCHEYIPYAKYALDKGYRITIHAGEQGVGQNVYDAISLLGAERIGHGIHINNHKDAYELVRAEAVALEACPSSNVQTKAVENIESHPFGDFYRDGLLVTINTDNRTVSDTTMTKELQLAAEKFNLSEQDYFQIYKISVENAFASDEVKQSLLKFIA
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Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. adenosine + H(+) + H2O = inosine + NH4(+) 2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+) Binds 1 zinc ion per subunit. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
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A3QJD9
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MIDTSIPLVDLHRHLDGNVRVETIWDLGHQHNIALPADTLEGLAPFVQIQGKESSLVAFLKKLDWMVAVLADLDAVKRVAYENVADAAISGLDYAELRFSPYYMAMNHKLPIEGVVEAVIDGVKAGLKDYEVKINLIGIMSRSFGQDACMQELEALLAHKQHLVAMDLAGDELGFPGALFNDHFKKVRDAGLAITAHAGEAAGAESMWQAIQELGATRIGHGVNAIHDPKLMEYLAANRIGIESCPTSNLHTSTVTSYQEHPLRTFMEAGVLIGLNTDDPGVSAIDIKHEYRTVKQEMGFSDAELAQLQRNGVEMAFISDSERKALYAAKA
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Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. adenosine + H(+) + H2O = inosine + NH4(+) 2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+) Binds 1 zinc ion per subunit. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
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Q8E8D4
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MINTSIPLVDLHRHLDGNVRVNTIWELGHQHGIALPADSLETLAPFVQIQGKETSLVAFLKKLDWMVAVLADLDAVKRIAYENVADAALSGLDYAELRFSPYYMAMNHKLPIEGVVEAVIDGVKAGLKDYQVNINLIGIMSRSFGQPACTQELEGLLAHKQHLVAMDLAGDELGFPGELFNEHFKRVRDAGLAITAHAGEAAGSQSMWQAIQELGATRIGHGVNAIHDPKLMEYLAKHRIGIESCPTSNLHTSTVSSYAEHPFRTFMDAGVLIGLNTDDPGVSAIDIKHEYRIAKFELGLSDAELAQVQRNGVEMAFLSESERKALYAAKA
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Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. adenosine + H(+) + H2O = inosine + NH4(+) 2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+) Binds 1 zinc ion per subunit. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
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A8H819
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MNYLQLPKIDLHCHLDGSVRPQTVIDLAKLQDVTIPSFNVDDIKALMVAPASCPNLDEYLTRFALPVSVMQTEAALERISFELFEDAAKENVKYLEVRFGPQLHQKMSLNFEQIIGSVVKGMRRAEAQYDIKGNYILSIIKVLPKDDINDVIDAGAKFLNNGVVAFDLAASEEPGFCHEYIPYAKYALEKGYRITIHAGEQGVGQNVYDAISLLGAERIGHGIHINSHQQAYELVKTEAVALETCPSSNVQTKAVESIESHPFGDFYRDGLLVTINTDNRTVSDTTMTKELQLAAEKFNLTEADYFAIYKMSVDNAFTSDEVKLSLLKFID
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Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. adenosine + H(+) + H2O = inosine + NH4(+) 2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+) Binds 1 zinc ion per subunit. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
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A4YCD7
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MIDTSIPLVDLHRHLDGNVRVNTIWELGHQHGIALPADSLETLAPFVQIQGKETSLVAFLKKLDWMVAVLADLDAVKRVAYENVADAALSGLDYAELRFSPYYMAMNHKLPIEGVVEAVVDGVKAGLKDYNVKINLIGIMSRSFGQAACTQELEGLLAHKQHLVAMDLAGDELGFPGELFNDHFKRVRDAGLAITAHAGEAAGSQSMWQAIQELGATRIGHGVNAIHDPKLMEYLAKHRIGIESCPTSNLHTSTVVSYAEHPFRTFMDAGVLISLNTDDPGVSAIDIKHEYRIAKSELKLTDAELARVQRNGVEMAFLSDSERKALYAAKI
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Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. adenosine + H(+) + H2O = inosine + NH4(+) 2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+) Binds 1 zinc ion per subunit. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
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A0LFB5
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MKWDTGRMARIIEAAQGKRVVDLCIRRCRLVNVLSGSIDTVDLAIHEGFVAGWGSYRAAREIDADGMYVCPGFIDGHIHIESTLLAPAQFCAAAVPQGTAAVVADPHEIANVLGLSGIRYFLEASEGLPLDFFFNLPSCVPATPLETSGAALRAPDLDALLPHERLIGLAEMMNFPGVLSGFPDVIDKLLLFQARRIDGHAPQLGDLGLNAYVAAGITSDHECTTLEEAREKLAKGMTVMIREGGQSRDLAALLPAVDEHTWPRCCFVSDDVHPDGLLREGHMNVIVNRAMSLGMAPVRALSLAALTPARHFRLDRRGALAPGYHADFSMSPTLNPWQPERVFKAGVEVARDGRLLLDLGNGNGVAAPPSPMHITRLLAEDLVVPAQPGLLRIIGVREGTLLTRKIVLPPKIHEGAAVADLDRDILKLAVYNRYVPDRPPAVAFVQGLGLKEGAIATTVAHDSHNLIVAGASDADILHVVDAVRKSGGGMAAGRTGAEVDVLALPIAGLMSDQPVERVAERLEQLQGRARAAGSGLRNPFMALSFLALPVIPELKLTDLGLIDVSTFSPVSLFETS
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adenine + H(+) + H2O = hypoxanthine + NH4(+) Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.
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B7IEM2
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MKIYEIVPVALGKKMPDVLIKNVNLVNVFTGKIEKTNIALYKKRIAGIGDDYKVGKEVIDAKGLFAIPGLIDAHVHIESSMLSPTEFAKLILPFGTTTIIADPHEIANVLGVEGIEYMIKSTEGIPLNVYFAIPSAVPATNLETSGATLGAEDMVSLVEKYPFRIIALGEVMNYPGVLDCDRDLITKIEILRHKYKKIDGHAPGLTGKELNAYIDAFVRSDHECETKEEALEKLSKGMQIFIREGTAARNLNALLPAVNEMNHFFFSFCTDDRDPNDIIERGHINGIIKSAIDSGIDPIIAIRMATINTAKYFNLRSMGAISPGYKADIVFIDNLKDFNIKFVIKDSKIVVEDKRINMNVESIIRNIPNTLGKINIVKNYSLSIKNRNRKIRVISVKSGTLLTDELIVEPNVEKGYVVSDIDRDIIKIAVFDRHKASGYSIGFVHGLSIKNGAVATTIGHDSHNLTVVGTNDEDMNYAISRIKELNGGIVVVKNKKLIASLSLPIAGLMSDKNYGFVVEELRKLKNSLVEIGVNSDILMQIHFLQLAVIPKLKITDKGLIDVEKQKIVDLFVEV
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adenine + H(+) + H2O = hypoxanthine + NH4(+) Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.
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A6LNR9
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MKIKEIIPVALGEKTPDLLIKNVKLLNVYTGNIEKTNIAILKKRIAGIGNEYNVGKEIFNAKNLYAIPGLIDAHVHIESSMLSPIEFAKMILPNGTTTIIADPHEIANVLGVEGINYMIKATEGIPLNVYFAIPSAVPATFLETSGAILGAEDMVSLLEKYPFRLIALGEVMNYPGVLNCDRELITKIEILRHKYKKIDGHAPGLSGKQLNAYIDAFVRSDHECETKSEALEKLSKGMHIFIREGTAARNLRSLIPAVNILNHFFFSFCTDDRDPEDIYKRGHINQIVKEAIGQGLDPVIAIRMATINTAKYFNLRSMGAISPGYKSDIVLVDNLYDFNILYVIKDSKFVVKDGKIDLKIESVFKDVPTTIGKINITKNYSLKVKNRNKKIRIISIKKFSLITEESIVSPKVSKNEIISDVENDIVKIAVFDRHNASGFSIGFVKGTGIKNGAIATTIGHDSHNLAVLGTNDKDMELAIKRILEINGGIVVIKDKKVISELSLPIAGLMSDETYNTVIKKLQHLKKSIEKLGTKNDVLMNIHFLQLAVIPKLKITDKGLIDVENQKIVDLFVEV
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adenine + H(+) + H2O = hypoxanthine + NH4(+) Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.
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C0HK25
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DPDKCKTIRVESWSYKYAEKVVEDASYVLNMTVVDRQSAAACTLGESFGYQKATLWVDHGCRADFKVCYLPVMPTECQTLRVESWNYKYAEKVVEGAALFINMTVEDRQSEASCDLDKSFGFYNQNSTVWVNHGCRADFNICYLKGAVTTSTINVSSWNYQYATKVLPAASCIYSMRVVNQQSAAPCTLGTTYGFVANTMWVDDGCRADFKPSYYSP
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Binds in decreasing order of affinity: galacturonic acid, D-galactosamine, methyl-alpha-D-galactopyranoside and further galactose-containing carbohydrates. Has hemagglutinating activity against human and rabbit erythrocytes. Optimum pH is 6-7. Activity is stable up to 60 degrees Celsius, then decreases and is lost at 80 degrees Celsius. Homodimer; disulfide-linked. Contains disulfide bonds. Dimer.
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Q2M832
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MSHQHTTQTSGQGMLERVFKLREHGTTARTEVIAGFTTFLTMVYIVFVNPQILGVAGMDTSAVFVTTCLIAAFGSIMMGLFANLPVALAPAMGLNAFFAFVVVQAMGLPWQVGMGAIFWGAIGLLLLTIFRVRYWMIANIPVSLRVGITSGIGLFIGMMGLKNAGVIVANPETLVSIGNLTSHSVLLGILGFFIIAILASRNIHAAVLVSIVVTTLLGWMLGDVHYNGIVSAPPSVMTVVGHVDLAGSFNLGLAGVIFSFMLVNLFDSSGTLIGVTDKAGLADEKGKFPRMKQALYVDSISSVTGSFIGTSSVTAYIESSSGVSVGGRTGLTAVVVGLLFLLVIFLSPLAGMVPGYAAAGALIYVGVLMTSSLARVNWQDLTESVPAFITAVMMPFSFSITEGIALGFISYCVMKIGTGRLRDLSPCVIIVALLFILKIVFIDAH
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High-affinity transporter for adenine. Internal adenine may inhibit transport. Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
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Q2M7X7
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MNNDNTDYVSNESGTLSRLFKLPQHGTTVRTELIAGMTTFLTMVYIVFVNPQILGAAQMDPKVVFVTTCLIAGIGSIAMGIFANLPVALAPAMGLNAFFAFVVVGAMGISWQTGMGAIFWGAVGLFLLTLFRIRYWMISNIPLSLRIGITSGIGLFIALMGLKNTGVIVANKDTLVMIGDLSSHGVLLGILGFFIITVLSSRHFHAAVLVSIVVTSCCGLFFGDVHFSGVYSIPPDISGVIGEVDLSGALTLELAGIIFSFMLINLFDSSGTLIGVTDKAGLIDGNGKFPNMNKALYVDSVSSVAGAFIGTSSVTAYIESTSGVAVGGRTGLTAVVVGVMFLLVMFFSPLVAIVPPYATAGALIFVGVLMTSSLARVNWDDFTESVPAFITTVMMPFTFSITEGIALGFMSYCIMKVCTGRWRDLNLCVVVVAALFALKIILVD
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High-affinity transporter for adenine. Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
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Q795L1
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MSKRNQARKVGRFMTMPNDPFKYSFDRLEDVADHISDVLRCPITIEDVNHKLLAYSTHSDCTDPARTSTIIGRRVPEKVINKLWKDGTIPALLKTDQPIRVKQIDEVGLSNRVAISIWKNKQVLGFIWALEIQKTLSDEDLLTLQMAAKAVKNKLLKLQIRKTKNEERSQEFFWKMLTGHIHQEDDMADGFHKLGMAAPSEFSVMIIRINGELTEKIEQQLQYLQETTQQVYVLLATVDSNELIILTSPKTDHPFQDLKQFALSTQKQLKERYKIEDVSIAFGGIYNSISFVSRSYQEALSVLKTKERFAEETKHLFSFSELGIYQYLDVLNEKRKQAGHYNYSLSKLEQYDRDHQSNMVETLERFIEADSNVNTASKLLNIHVNTLNYRLKRISQIAEIDLKNVNQKFTIYLDIKLRHMDL
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Activates ald expression in response to alanine availability and is important for normal sporulation in B.subtilis. Disruption of adeR causes a sporulation defect. Belongs to the CdaR family.
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C7F8K6
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MFDPIGKSGDAFALAKDYALEAKNWGADLSLKAYVDERVAAEDLKVGKCDGAIISGLRGRQFNKYTGSLDAVGALTNMKTAINAYKLLSSPMAAKNMVVGPYEIAGLGTIGPAYLFVNDRSINTLAKAAGKKIGVFKYDEAQPKLVQHVGGQAVSVDVTNAGAKFNNHEIDIVPAPIVAFKPFELYKGLGEKGAIVRFPLTQISADFIIRKDQFPAGFGQKSRTWVASQLNRTFGIIAKYESDIPSKYWMDIPKNEQLNYMKMMREARIQLTKAGIYDPKMMNFLKKVRCKENPSNFECALNDE
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Mediates antimicrobial resistance via active efflux. Contributes to resistance to antibiotics such as chloramphenicol, erythromycin and novobiocin (PubMed:21212056). May be part of a tripartite ATP-independent periplasmic (TRAP) transport system (Probable). Deletion of the gene results in increased susceptibility to different antibiotics, dyes, detergents and disinfectants. Belongs to the bacterial solute-binding protein 7 family.
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C7F8K7
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MGSTSGIGLIPNNRTARNLLQLLNHPTIEKRLINKDYEAVGMIPVGTANMVMKTKKISKVAQLRGQRIGVLANNPPQQALVRSVGAQPVYVDLSNAIAQFQQNKIDIMPAPVYGLLPYNLQKDFGPDTQVINFPLAYFGVNIIIKPQAYPANFGRKIRAWFVQNSQLLTNRAIQWENHLPAYYWVDVSFYEKQSYDIMVAKIRNQYVRSGYYDAYFVELMKRLRCIDDPRYFECPMSR
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Mediates antimicrobial resistance via active efflux. Contributes to resistance to antibiotics such as chloramphenicol, erythromycin and novobiocin (PubMed:21212056). May be part of a tripartite ATP-independent periplasmic (TRAP) transport system (Probable). Deletion of the gene results in increased susceptibility to different antibiotics, dyes, detergents and disinfectants. Belongs to the bacterial solute-binding protein 7 family.
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Q6FCU0
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MNQSELIRALPKAELHVHIEGTFEPELMFEIAQRNHIDIPYKSVEEIKKAYNFHNLQSFLDIYYAGANVLINEQDFYDLAWAYFKKCAEDRVVHTEMFFDPQTHTERGVSFEIVLNGLKRACKDAKEHLGISSHLIMCFLRHLSEEDAFKTLEQALPYKADIIAVGLDSSEVGHPPSKFARVFEKAREEGFLVVAHAGEEGPPEYVWEALDLLKVNRIDHGVRSEEDPALMQRLIQEKMPLTVCPLSNLKLCVVNDMKEHNIRRLLNQGVHVTVNSDDPSYFGGYMNDNFVAIQAALDLSNEELKKLAINSFEASFIDEEEKQNWIEEINQI
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Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. adenine + H(+) + H2O = hypoxanthine + NH4(+) Binds 1 zinc ion per subunit. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.
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Q8UJ05
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MTSHLLKAEIHCHLEGAAPPALVVKQAEKYGIDTSGFLRDGQYVWSDFAEFIQCYDAVAQVFKSDEDYAVLTETYLTELAEANTIYSELIISPDHGDRIGLGADAYLAGVAEGIRIAKEKTGIETRIIVTGERHFGPERVIAAAEYAARIRHPLVTGFNMAGEERMGRVADYARAFDIARDAGLGLTIHAGEVCGPESVADALDLVKPSRIGHGVRAIEDAALISRLVETGTVLEVCPGSNIALSVYPDFASHPLKALSDAGVRVCISSDDPPFFFTSLAREYALAADAFGFNDAEINRMTRTALECAFVDEATRERLLARLGDA
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Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. adenine + H(+) + H2O = hypoxanthine + NH4(+) Binds 1 zinc ion per subunit. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.
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B9J6V8
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MTSHLKKVELHCHLEGAAPPALTLAQARKYNVDTNAFMRDGVYLWKDFAEFLVCYDKVSEVYRTEEDYALLTETYLEELAGIGTIYSELIVSPDHGDRIGLGADAYMEGVSAGIRAAKEKSGIEARLIVTGERHFGPERVVKAAEYAAKSDNPLISGFNMAGEERMGRVADYARAFDIAREAGLGITIHAGEVCGAFSVADAVELVRPARIGHGVRAIEDADLVKRLADLGTVLEVCPGSNIALNVFPDFPSHPLRKLRDAGVRVTISSDDPPFFHTSLKREYELASTAFGFSDDEINAMTRTAIEAAFLDEATRAALLARL
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Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. adenine + H(+) + H2O = hypoxanthine + NH4(+) Binds 1 zinc ion per subunit. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.
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B9JYP8
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MTASLLKAELHCHIEGAAPPALVAAQAEKYGIDASSFIRNGSYVWEDFTSFIAAYDFVASVFRTEEDFAALAEAYLIELAGVNTIYSELFVSPDHGEAVGLSAEAYIEGLAEGIVAARIKTGIECRMVIIGERHLGPENVLRRAKWLADYHHPLITGFNMAGEERMNRVADYAPAFDIAREAGYGITIHAGELCGAFSVRDALDLVRPSRIGHGVRAIEDADLVQRLADEGVVLEVCPASNIALKVFEDYASHPMRDLTDAGVRVCINSDDPPFFATSLANDYAIAASMGFSDVEIDAMTRTAIEAAFVDEATRQNLLQRLQAAGSGDEAAI
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Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. adenine + H(+) + H2O = hypoxanthine + NH4(+) Binds 1 zinc ion per subunit. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.
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Q21T97
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MTIKPVSQERLPELLRTIPKAELHIHIEGSLEPELMFALAQRNGVSIPYPDVASLRAAYVFDNLQSFLDIYHAGTLVLRTEQDFYDMTHAYLARAAADNVLHAEIFFDPQTHTAHGVSADVVINGLYRACVDARVEFDMNASLILCFLRHLSEQEAFECLEQALPHLDKLVGVGLASSEMGHPPEKFARVFARARELGLRLVAHAGEEGPPAYIWSALDVLKVERIDHGVQAVQDPLLMARLARDRIALTVCPLSNLKLRVFPTLAAHNLGRLLEAGIVATVNSDDPSYFGGYINQNFTQTFAALGLTAQHAYQLAHNSFEASFIDDRLKRQYFDRLAGVFETFE
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Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. adenine + H(+) + H2O = hypoxanthine + NH4(+) Binds 1 zinc ion per subunit. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.
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Q4X1Q4
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MCQSPLHDFLHGLPKCEHHVHLEGCVTPELIFQLAEKNNIQLPNPATHPAYASVEALRARYAEFTSLNDFLDFYFHGMSVLHHQSDFEELAWAYFQKAHADGVHHAEVFFDPQVHQARGIDYETVVSGFTAGCKRAERELGLSTRLILCFVRHLPVDSATKLYELALASNHFESRVVHGLGWSSSEVGPPKDMFREIYASASGKGIRLTAHAGEEGDPTYISTALELGARRIDHGIRLVEDPELMERVAREGIMLTVCPLSNVRLRCVQSVEQVPIRKFLDAGVKFSINSDDPAYFGGYILDNYCAVQEAFQLSILEWRVIAENSVNESWIDEARKAELLKRIDDHVQKHTVVA
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Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. adenine + H(+) + H2O = hypoxanthine + NH4(+) Binds 1 zinc ion per subunit. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.
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Q2TZN9
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MCKSDLHDFLHGLPKCEHHVHLEGCLAPDLIFELAKRNNVSLPNEPAYESIEALSHRYGHFTSLDDFLRFYFIGMSVLHHESDFADLAWAYFQKAHADGVHHAEVFFDPQVHRDRGIPYETIVSGFVAGCQRAERELGLTTRLILCFVRHLPVDNAARVYQEALDQEHFDNEVVHGLGWSSTEVGPPKDMFRELYSSASAKGIRLTAHAGEEGDPSYISAALELGAQRIDHGIRLVEDPVLMEKVVRDRIMLTVCPISNLQLRCVESIAHVPIRKFLDAGVMFSINSDDPAYFGGYILDNYCAVQEAFQLTVDEWRVIAENSIKGSWIGEERKTELLKRIDDHVQRHVAAV
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Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. adenine + H(+) + H2O = hypoxanthine + NH4(+) Binds 1 zinc ion per subunit. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.
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C1DGB0
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MYAWLNALPKAELHLHLEGSLEPELLFALAERNKVALPWPDVESLRKAYAFNNLQEFLDLYYQGANVLRTEQDFYDLTWAYLRKCKEQNVVHTEPFFDPQTHTDRGIPFETVLSGIGQALEDGRKRLGIGSGLILSFLRHLSEEEAHKTLDQALPFRHAFIAVGLDSSEKGHPPRKFRQVFERARAEGFATVAHAGEEGPPEYIWEALDLLKVKRIDHGVRAAEDPRLLERLIDEQIPLTVCPLSNVKLRVFKDMSEHNILKLLEMGVKVTVNSDDPAYFGGYVTENFVALQESLGMTCEQAERLAQNSLDARLA
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Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. adenine + H(+) + H2O = hypoxanthine + NH4(+) Binds 1 zinc ion per subunit. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.
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Q2KWR7
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MQDWLTALPKAELHIHLEGALEPELLFALAQRNGVTLPWPDIDALRQAYQYQNLQEFLDLYYQGAHVLRTEQDFYDLTWAYLRKCAEQGVTHTEPFFDPQTHTDRGVPFQVVLSGIQAALADGRRDLGIQSGLILSFLRHLPEEAAMRTLDEALPYRDAFIAVGLDSSEAGFPPRLFERVFARARAEGLPAVAHAGEEGPPEYIWEALERLQVKRIDHGVRAWEDPRLIAHLVDTQIPLTVCPLSNVRLQVFEHMGQHNVLEMLERGLNVCINSDDPAYFGGYVLENFMALREHLGMSQEQARRLAANSLASVLTA
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Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. adenine + H(+) + H2O = hypoxanthine + NH4(+) Binds 1 zinc ion per subunit. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.
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Q7WMY6
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MYDWLNALPKAELHLHLEGTLEPGLMFELARRNGVALPWPDVESLRRAYDYDNLQEFLDLYYRGAEVLRTEQDFYDLTWAYLLKCREQNVVHTEPFFDPQTHTDRGIAFETVLAGITQALEDGRTQLGIQGGLILSFLRHLPEEAAMRTLEQALPYRDAFIAVGLDSSERGFPPRLFQRVFERARAAGLPAVAHAGEEGPPEYIWEALDLLQVRRIDHGVRAAEDERLIERLIDTQIPLTVCPLSNTRLRVFDSMAEHNILELLERGVKVTVNSDDPAYFGGYITENFHALHEHLGMTQDQARRLAANSMDARLAGG
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Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. adenine + H(+) + H2O = hypoxanthine + NH4(+) Binds 1 zinc ion per subunit. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.
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Q7WBG5
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MYDWLNALPKAELHLHLEGTLEPGLMFELARRNGVALPWPDVESLRRAYDYDNLQEFLDLYYRGAEVLRTEQDFYDLTWAYLLKCREQNVVHTEPFFDPQTHTDRGIAFETVLAGITQALEDGRTQLGIQGGLILSFLRHLPEEAAMRTLEQALPYRDAFIAVGLDSSERGFPPRLFQRVFERARAAGLPAVAHAGEEGPPEYIWEALDLLQVRRIDHGVRAAEDERLIERLIDTQIPLTVCPLSNTRLRVFDSMAEHNILELLERGVKVTVNSDDPAYFGGYITENFHALHEHLGMTQDQARRLAANSMDARLAGG
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Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. adenine + H(+) + H2O = hypoxanthine + NH4(+) Binds 1 zinc ion per subunit. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.
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P25141
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MSSNTAGQVIRCKAAVAWEAGKPLVIEEVEVAPPQKMEVRLKILFTSLCHTDVYFWEAKGQTPLFPRIFGHEAGGIVESVGEGVTDLKPGDHVLPVFTGECQQCRHCKSEESNMCDLLRINTDRGVMIHDGQTRFSKDGKPIYHFVGTSTFSEYTVCHSGCVTKIDPQAPLDKVCVLSCGISTGLGATLNVAKPTKGSTVAIFGLGAVGLAAAEGARIAGASRIIGVDLNPSRFNDAKKFGVTEFVNPKDHGDKPVQQVIAEMTDGGVDRSVECTGNVNAMISAFECVHDGWGVAVLVGVPNKDDAFKTHPMNLLNERTLKGTFFGNYKPKSDIPSVVDKYMKKELELEKFITHQVPFSEINKAFDYMLKGESIRCMITMEH
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This protein is responsible for the conversion of alcohols to aldehydes in plants and is important for NAD metabolism during anaerobic respiration. a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH a secondary alcohol + NAD(+) = a ketone + H(+) + NADH Binds 2 Zn(2+) ions per subunit. Homodimer. Belongs to the zinc-containing alcohol dehydrogenase family.
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A3LNN7
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MSVPTTQKAVVFESNGGPLLYKDIPVPTPKPNEILINVKYSGVCHTDLHAWKGDWPLDTKLPLVGGHEGAGVVVGIGSNVTGWELGDYAGIKWLNGSCLNCEFCQHSDEPNCAKADLSGYTHDGSFQQYATADAVQAARLPKGTDLAQAAPILCAGITVYKALKTAQIQPGNWVCISGAGGGLGSLAIQYAKAMGFRVIAIDGGEEKGEFVKSLGAEAYVDFTVSKDIVKDIQTATDGGPHAAINVSVSEKAIAQSCQYVRSTGTVVLVGLPAGAKVVAPVFDAVVKSISIRGSYVGNRADSAEAIDFFTRGLIKCPIKVVGLSELPKVYELMEAGKVIGRYVVDTSK
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Converts ethanol to acetaldehyde and plays a major role in xylose fermentation. a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH a secondary alcohol + NAD(+) = a ketone + H(+) + NADH Binds 2 Zn(2+) ions per subunit. Homotetramer. Belongs to the zinc-containing alcohol dehydrogenase family.
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Q03505
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MSTAGKVIKCKAAVLWQLNKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHAVTGSIAVPLPVILGHEAAGIVESIGEGVTTVKPGDKVIPLFTPQCGKCRICKHPESNFCLINDLGKPKGMLLDGTSRFTCKGKPIHHFIGTSTFSQYTVVDEIAVAKIDAAAPLEKVCLIGCGFSTGYGSAVKVAKVTPGSTCAVFGLGGVGLSVIMGCKAAGASRIIAVDINKDKFPKAKEVGATECINPQDYKKPIQEVIQEISDGGVDFSFEVIGRLDTVVAALLSCHGACGTSVIVGVPPDSQSLTVNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFSLDPLITNVLPFEKINEGFDLLRSGKSIRTILTF
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a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH a secondary alcohol + NAD(+) = a ketone + H(+) + NADH Binds 2 Zn(2+) ions per subunit. Homodimer. Belongs to the zinc-containing alcohol dehydrogenase family.
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P06757
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MSTAGKVIKCKAAVLWEPHKPFTIEDIEVAPPKAHEVRIKMVATGVCRSDDHAVSGSLFTPLPAVLGHEGAGIVESIGEGVTCVKPGDKVIPLFSPQCGKCRICKHPESNLCCQTKNLTQPKGALLDGTSRFSCRGKPIHHFISTSTFSQYTVVDDIAVAKIDAAAPLDKVCLIGCGFSTGYGSAVQVAKVTPGSTCAVFGLGGVGLSVVIGCKTAGAAKIIAVDINKDKFAKAKELGATDCINPQDYTKPIQEVLQEMTDGGVDFSFEVIGRLDTMTSALLSCHSACGVSVIVGVPPSAQSLSVNPMSLLLGRTWKGAIFGGFKSKDAVPKLVADFMAKKFPLEPLITHVLPFEKINEAFDLLRAGKSIRTVLTF
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a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH a secondary alcohol + NAD(+) = a ketone + H(+) + NADH Binds 2 Zn(2+) ions per subunit. Dimer of identical or non-identical chains of three types (A, B, C), which are coded by 3 separate genes at different loci. Belongs to the zinc-containing alcohol dehydrogenase family. Class-I subfamily.
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P14673
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MSTTVGQVIRCKAAVAWEAGKPLVMEEVDVAPPQKMEVRLKILYTSLCHTDVYFWEAKGQNPVFPRILGHEAAGIVESVGEGVTELGPGDHVLPVFTGECKDCAHCKSEESNMCSLLRINTDRGVMINDGQSRFSINGKPIYHFVGTSTFSEYTVVHVGCVAKINPLAPLDKVCVLSCGISTGLGATLNVAKPTKGSSVAIFGLGAVGLAAAEGARIAGASRIIGVDLNASRFEQAKKFGVTEFVNPKDYSKPVQEVIAEMTDGGVDRSVECTGHIDAMISAFECVHDGWGVAVLVGVPHKEAVFKTHPMNLLNERTLKGTFFGNYKPRSDIPSVVEKYMNKELELEKFITHTLPFAEINKAFDLMLKGEGLRCIITMED
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a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH a secondary alcohol + NAD(+) = a ketone + H(+) + NADH Binds 2 Zn(2+) ions per subunit. Homodimer (By similarity). Homotetramer. By fungal elicitor. Belongs to the zinc-containing alcohol dehydrogenase family.
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P80338
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STAGKVIKCKAAVLWEPKKPFSIEEVEVAPPKAHEVRVKIIATGICRSDDHVISGVLVMPFPIILGHEAAGVVESVGEGVTSVKPGDKVIPLFVPQCGECSVCLSTKGNLCRKNDIGPASALMPDGTSRFTCKGKAIHHFAGTSTFTEYTVLHETAVAKIDAAAPLEKVCLIGCGFSTGYGAALQTAKVEPGSTCAVFGLGGVGLSVVMGCKAAGASRIIGVDINKDKFAKAKELGATDCVNPKDFTKPIHEVLMEMTGLGVDYSFEVIGHTETMAAALASCHFNYGVSVIVGVPPAAEKLSFDPMLLFSGRTWKGSVFGGWKSKDSVPKLVADYMEKKFVLDPLITHTLPFHKINEGFDLLRTGKSIRSVLLF
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a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH a secondary alcohol + NAD(+) = a ketone + H(+) + NADH Binds 2 Zn(2+) ions per subunit. Homodimer. Belongs to the zinc-containing alcohol dehydrogenase family. Class-I subfamily.
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A0A2I7G3B2
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MAHKAPSVITCKAAVVWELGGPVVLEEIKVDPPKASEVRIKMLCASICHTDVLCTKGFPIPLFPRIPGHEGVGVIESVGIDAKGLKPGDIVMPLYLGECGQCLNCKTGKTNLCHVYPPPFSGLMNDGTSRMTIARTGESIYHFTSCSTWTEYAVADCNYVLKIDPKISYPHASFLSCGFTTGFGATWRETQVSKGSSVAVFGIGTVGLGVIKGAQLAGASKIIGVDVNQYKAAKGKVFGMTDFINPKDHPNKTVSELVKEITHGLGVDYCFECTGVPSLLNEALEASKFGIGTVVPIGAGGEASVAINSLILFSGRTLKCTTFGGVRTQSDLPVIIDKCLNKEIQLDELLTHEIQLENIQAAFEILKKPDCVKILINF
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Binds 2 Zn(2+) ions per subunit. Isoprenoid biosynthesis. Homodimer. Expressed in flowers and disk florets. Belongs to the zinc-containing alcohol dehydrogenase family. Class-IV subfamily.
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P13603
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MSNTAGQVIKCRAAVAWEAGKPLVIEEVEVAPPQAGEVRLKILFTSLCHTDVYFWEAKGQTPLFPRIFGHEAGGIVESVGEGVTHLKPGDHALPVFTGECGECPHCKSEESNMCNLLRINTDRGVMINDNKSRFSIKGQPVHHFVGTSTFSEYTVVHAGCVAKINPDAPLDKVCILSCGICTGLGATVNVAKPKPGSSVAIFGLGAVGLAAAEGARMSGASRIIGVDLVSSRFELAKKFGVNEFVNPKDHDKPVQQVIAEMTDGGVDRAVECTGSIQAMISAFECVHDGWGVAVLVGVPKKDDAFKTHPMNFLNERTLKGTFYGNYKPRTDLPNVVEQYMKGELELEKFITHSIPFSEINKAFDYMLKGESIRCIIRMEE
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a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH a secondary alcohol + NAD(+) = a ketone + H(+) + NADH Binds 2 Zn(2+) ions per subunit. Homodimer. Belongs to the zinc-containing alcohol dehydrogenase family.
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D6W1Y3
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MSIPETQKGVIFYESHGKLEYKDIPVPKPKANELLINVKYSGVCHTDLHAWHGDWPLPVKLPLVGGHEGAGVVVGMGENVKGWKIGDYAGIKWLNGSCMACEYCELGNESNCPHADLSGYTHDGSFQQYATADAVQAAHIPQGTDLAQVAPILCAGITVYKALKSANLMAGHWVAISGAAGGLGSLAVQYAKAMGYRVLGIDGGEGKEELFRSIGGEVFIDFTKEKDIVGAVLKATDGGAHGVINVSVSEAAIEASTRYVRANGTTVLVGMPAGAKCCSDVFNQVVKSISIVGSYVGNRADTREALDFFARGLVKSPIKVVGLSTLPEIYEKMEKGQIVGRYVVDTSK
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This isozyme preferentially catalyzes the conversion of primary unbranched alcohols to their corresponding aldehydes. Also shows activity toward secondary alcohols. a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH a secondary alcohol + NAD(+) = a ketone + H(+) + NADH Binds 2 Zn(2+) ions per subunit. Homotetramer. PubMed:320000 sequence has several conflicting residues and reports microheterogeneities at additional postitions. Analysis of the sequence suggests that the sequenced protein was a mixture of at least 3 of the different isoforms of alcohol dehydrogenases found in yeast. Belongs to the zinc-containing alcohol dehydrogenase family.
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Q07264
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IIESVGEGVTDVAPGDHVLPVFTGECKECAHCKSAESNMCDLLRINTDRGVMIGDGKSRFSINGKPIYHFVGTSTFSEYTVMHVGCVAKINPQAPLDKVCVLSCGISTGLGASINVAKPPKGSTVAVFGLGAVGLAAAEGARIAGASRIIGVDLNPSRFEEARKFGCTEFVNPKDHNKPVQEVLAEMTNGGVDRSVECTGNINAMIQAFECVHDGWGVAVLVGVPHKDAEFKTHPMNFLNERTLKGTFFGNYKPRTDLPNVVELYMKKELEVEKFITHSVPFAEINKAFDLMA
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a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH a secondary alcohol + NAD(+) = a ketone + H(+) + NADH Binds 2 Zn(2+) ions per subunit. Homodimer. Belongs to the zinc-containing alcohol dehydrogenase family.
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Q6Y8J4
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MKAAVITKDHTIEVKDTKLRPLKYGEALLEMEYCGVCHTDLHVKNGDFGDETGRITGHEGIGIVKQVGEGVTSLKVGDRASVAWFFKGCGHCEYCVSGNETLCRNVENAGYTVDGAMAEECIVVADYSVKVPDGLDPAVASSITCAGVTTYKAVKVSQIQPGQWLAIYGLGGLGNLALQYAKNVFNAKVIAIDVNDEQLAFAKELGADMVINPKNEDAAKIIQEKVGGAHATVVTAVAKSAFNSAVEAIRAGGRVVAVGLPPEKMDLSIPRLVLDGIEVLGSLVGTREDLKEAFQFAAEGKVKPKVTKRKVEEINQIFDEMEHGKFTGRMVVDFTHH
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a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH a secondary alcohol + NAD(+) = a ketone + H(+) + NADH Binds 2 Zn(2+) ions per subunit. Inhibited by ethanol. Alcohol metabolism; ethanol biosynthesis via fermentation pathway. Multimeric (with different ratios of monomers). In Z.mobilis there are two isozymes of alcohol dehydrogenase. Belongs to the zinc-containing alcohol dehydrogenase family.
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O45687
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MSSANIPATQSALIFEKYGGPLEVRQVSVPQPQENELLVKIEYSGICHSDLHTWEGDFEYASICPLIGGHEGAGTVVTIGSKVKGWNIGDRAGIKLINANCLNCEYCKTGHEPLCDHIQNYGIDRHGTFQEYLTIRDIDAIKVSNDTNLAAAAPVLCGGVTAYKSLKATNVKPGQIVVLTGAGGGLGSFGIQYAKAMGMRVVAVDHISKEDHCRNLGAEWFVDAFDTPDIVAHIRKLTNGGAHGVVSFAAAKKPMEYALEYVRKRGTVVFVGLPKDGTIPLDTLSLICNEITVKGSIVGSRMDVDEAIDFITRGIVHVPIELVKLEDVPSVYQRMKDGKVTSRVVVDFSMR
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a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH a secondary alcohol + NAD(+) = a ketone + H(+) + NADH Binds 2 Zn(2+) ions per subunit. Homotetramer. Belongs to the zinc-containing alcohol dehydrogenase family.
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Q5A749
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MSVPTTQKAVIFETNGGKLEYKDIPVPKPKANELLINVKYSGVCHTDLHAWKGDWPLATKLPLVGGHEGAGVVVALGENVKGWKVGDYAGVKWLNGSCLNCEYCQSGAEPNCAEADLSGYTHDGSFQQYATADAVQAARIPAGTDLANVAPILCAGVTVYKALKTAELEAGQWVAISGAAGGLGSLAVQYAKAMGYRVLAIDGGEDKGEFVKSLGAETFIDFTKEKDVVEAVKKATNGGPHGVINVSVSERAIGQSTEYVRTLGKVVLVGLPAGAKISTPVFDAVIKTIQIKGSYVGNRKDTAEAVDFFTRGLIKCPIKIVGLSELPEVYKLMEEGKILGRYVLDNDK
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a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH a secondary alcohol + NAD(+) = a ketone + H(+) + NADH Binds 2 Zn(2+) ions per subunit. Homotetramer. Belongs to the zinc-containing alcohol dehydrogenase family.
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P48815
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MGLSGKNVIFVGGLGFIGYEACKQLMAKNMASFFVFDVLDKPENIKALQALNPKTKVYYTKFDITSKQSIKSALADVVAKVKYIDALINGAGILTDPNVELTMNINLIGLINTTLEGLPLMDKNKQGRGGVIVNIASVLGLEPCPPAAVYCASKFGVMGFSRSIGDPYYYNITGVAVVTFCPGLTETPLKNNIGSKYTFEYSKKISEELNSTKTQKPEVCGAHLAQVVESHENGGIYISNQGTLAKVTPTVYWQPTYH
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a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH a secondary alcohol + NAD(+) = a ketone + H(+) + NADH Homodimer. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
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Q70UP5
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MGLSGKNVIFVGGLGFIGYEACKQLMAKNMASFFVFDVLDKPEDIKALQALNPKTKVYYTKFDITSKQSIKSALADVVSKVKYIDALINGAGILTDLNVELTMNINLIGLINTTLEALPLMDKNKQGRGGVIVNIASVLGLEPCPPAAVYCASKFGVMGFSRSIGDPYYYNITGVAVVTFCPGLTETPLKNNIGSKYTFEYSKKISEELNNTKTQKPEVCGAHLAQVVESHENGGIYISNQGTLAKVTPTVYWQPTYH
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a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH a secondary alcohol + NAD(+) = a ketone + H(+) + NADH Homodimer. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
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Q70UP6
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MGLSGKNVIFVGGLGFIGYEACKQLMAKNMASFFVFDVLDKPEDIKALQALNPKTKVYYTKFDITSKQSIKSALADVVSKVKYIDALINGAGILTDLNVELTMNINLIGLINTTLEGLPLMDKNKQGRGGVIVNIASVLGLEPCPPAAAYCASKFGVMGFSRSIGDPYYYNITGVAVVTFCPGLTETPLKNNIGSKYTFEYSKKISEELNNTKTQKPEVCGAHLAQVVESHENGGIYISNQGTLAKVTPTVYWQPTYH
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a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH a secondary alcohol + NAD(+) = a ketone + H(+) + NADH Homodimer. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
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P27581
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MAIANKNIIFVAGLGGIGFDTSREIVKSGPKNLVILDRIENPAAIAELKALNPKVTVTFYPYDVTVSVAETTKLLKTIFDKLKTVDLLINGAGILDDYQIERTIAVNFTGTVNTTTAIMSFWDKRKGGPGGVIANICSVTGFNAIYQVPVYSASKAAALSFTNSLARLAPITGVTAYSINPGITKTTLVHKFNSWLDVEPRVAELLLEHPTQTTLQCAQNFVKAIEANQNGAIWKLDLGTLEAIEWTKHWDSHI
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a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH a secondary alcohol + NAD(+) = a ketone + H(+) + NADH Homodimer. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
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P25720
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MAIANKNIIFVAGLGGIGFDTSREIVKSGPKNLVILDRIENPAAIAELKALNPKVTVTFYPYDVTVPVAETTKLLKTIFDKLKTVDLLINGAGILDDYQIERTIAVNFTGTVNTTTAIMAFWDKRKGGPGGVIANICSVTGFNAIYQVPVYSASKAAALSFTNSLAKLAPITGVTAYSINPGITKTTLVHKFNSWLDVEPRVAELLLEHPTQTTLQCAQNFVKAIEANQNGAIWKLDLGRLEAIEWTKHWDSGI
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a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH a secondary alcohol + NAD(+) = a ketone + H(+) + NADH Homodimer. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
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P23237
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MAIANKNIIFVAGLGGIGLDTSREIVKSGPKNLVILDRIDNPAAIAELKAINPKVTITFYPYDVTVSVAESTKLLKVIFDKLKTVDLLINGAGILDDYQIERTIAVNFAGTVNTTTAIMAFWDKRKGGPGGVIANICSVTGFNAIYQVPVYSASKAAALSFTNSLAKLAPITGVTAYSINPGITKTTLVHKFNSWLDVEPRVAELLLEHPTQTTLQCAQNFVKAIEANKNGAIWKLDLGRLDAIEWTKHWDSGI
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a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH a secondary alcohol + NAD(+) = a ketone + H(+) + NADH Homodimer. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
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P48587
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MAIANKNIIFVAGLGGIGLDTSREIVKSGPKNLVILDRIDNPTAIAELKAINPKVTVTFYPYDVTVPVAETTKLLKTIFAQLKTVDLLINGAGILDDHQIERTIAVNFTGTVNTTTAIMEFWDKRKGGPGGVIANICSVTGFNAIYQVPVYSASKAAALSFTNSLARLAPITGVTAYSINPGITRTPLVHKFNSWLDVEPRVGELLLEHPTQTTLECAQNFVKAIEANKNGAIWQLDLGQLIAVEWTKHWDSHI
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a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH a secondary alcohol + NAD(+) = a ketone + H(+) + NADH Homodimer. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
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P28484
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MAFTLTNKNVVFVAGLGGIGLDTSKELVKRDLKNLVILDRIENPAAIAELKAINPKVTVTFYPYDVTVPIAETTKLLKTIFAQLKTIDVLINGAGILDDHQIERTIAVNYTGLVNTTTAILDFWDKRKGGPGGIICNIGSVTGFNAIYQVPVYSGTKAAVVNFTSSLAKLAPITGVTAYTVNPGITRTTLVHKFNSWLDVEPQVAEKLLAHPTQPSLACAENFVKAIELNQNGAIWKLDLGTLEAIQWSKHWDSGI
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a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH a secondary alcohol + NAD(+) = a ketone + H(+) + NADH Homodimer. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
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P51550
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MSTTLTNKNVIFVAGLGGIGLDTSKELVKRDLKNLVILDRIDNPAAIAELKAINPKVTVTFYPYDVTVPITETTKLLKTIFAKVKTVDILINGAGILDDHQIERTIAVNYTGLVNTTTAILDFWDKRKGGPGGIICNIGSVTGFNAIYQVPVYSGTKAAVVNFTSSLAKLAPITGVTAYTVNPGITRTTLVHKFNSWLDVEPLVSEKLLAHPTQPSQACAENFVKAIELNKNGAIWKLDRGTLEPIQWTKHWDSGI
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a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH a secondary alcohol + NAD(+) = a ketone + H(+) + NADH Homodimer. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
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Q9U8P1
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MAIANKNIIFVAGLGGIGLDTSREIVKSGPKNLVILDRIENPTAIAELKAINPKVTVTFYPYDVTVPVAETTKLLKTIFAKLKTVDLLINGAGILDDHQIERTIAVNFTGTVNTTTAIMEFWDKRKGGPGGVIANICSVTGFNAIYQVPVYSASKAAALSFTNSLARLAPITGVTAYSINPGITRTPLVHKFNSWLDVEPRVGELLLEHPTQTTLECAQNFVKAIEANQNGAIWQLDLGRLISVEWTKHWDSHI
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a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH a secondary alcohol + NAD(+) = a ketone + H(+) + NADH Homodimer. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
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Q9TY31
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MALTNKNIIFVAGLGGIGLDTSRELVKRDLKNLVILDRIDNPAAIAELKAINPKVTVTFYPYDVTTPLTETTKLLKTIFAQLKTVDVLINGAGILDDHQIERTIAVNFTGLVNTTTAILDFWDKRKGGPGGVICNIGSVTGFNAIYQVPVYSASKAAVVSFTQSIAKLANVTGVTAFTVNPGITKTTLVHKFNSWLDVETRVAEKLLEHPTQTTLACAQNFVKAIELNKNGAIWKLDLGTLEPIEWTKHWDSGI
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a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH a secondary alcohol + NAD(+) = a ketone + H(+) + NADH Homodimer. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
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B4P0U4
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MAFTLTNKNVVFVAGLGGIGLDTSKELVKRDLKNLVILDRIENPAAIAELKAINPKVTVTFYPYDVTVPIAETTKLLKTIFAQLKTIDVLINGAGILDDHQIERTIAVNYTGLVNTTTAILDFWDKRKGGPGGIICNIGSVTGFNAIYQVPVYSGTKAAVVNFTSSLAKLAPITGVTAYTVNPGITRTTLVHKFNSWLDVEPQVAEKLLAHPTQPSLACAQNFVKAIELNQNGAIWKLDLGTLEAIQWSKHWDSGI
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a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH a secondary alcohol + NAD(+) = a ketone + H(+) + NADH Homodimer. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
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P17648
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MSSTEGKVICCRAAVAWEAGKPLVIEEVEVAPPQANVVRVKILYTSLCHTDVYFWEAKGQNPLFPRIYGHEAGGIVESVGEGVTDLKAGDHVLPVFTGECKECDHCKSEESNMCDLLRINTDRGVMLNDGKSRFSIKGKPIYHFVGTSTFSVYTVTHVGCLAKINPQSPLDKVCILSCGISTGLGATLNVRKPKKGSTVAVFGLGAVGLAAAEGARMAGASRIIGVDLNSNRFEEAKKFGITEFVNPKDHKKPVQEVIAELTNGGVDRSIECTGNIQAMIPAFECVHDGWGVAVLVGVPHKDAVFTTHPMNFLNERTLKGTFFGNYKPRTDIPSVVEKYMNKELEVDKFITHQLPFSQINKAFDYMLKGEGIRCIITMEE
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This protein is responsible for the conversion of alcohols to aldehydes in plants and is important for NAD metabolism during anaerobic respiration. a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH a secondary alcohol + NAD(+) = a ketone + H(+) + NADH Binds 2 Zn(2+) ions per subunit. Homodimer. Belongs to the zinc-containing alcohol dehydrogenase family.
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P48977
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MSNTAGQVIRCRAAVAWEAGKPLVIEEVEVAPPQANEVRIKILFTSLCHTDVYFWEAKGQNPLFPRIYGHEAGGIVESVGEGVTDLKAGDHVLPVFTGECKDCAHCKSEESNMCDLLRINTDRGVMLSDGKSRFSIKGKPIYHFVGTSTFSEYTVVHVGCLAKINPSAPLDKVCLLSCGISTGLGATLNVAKPKKGSTVAVFGLGAVGLAAAEGARLSGASRIIGVDLHSDRFEEAKKFGVTEFVNPKAHEKPVQEVIAELTNRGVDRSIECTGSTEAMISAFECVHDGWGVAVLVGVPHKDAVFKTHPVNFLNERTLKGTFFGNYKTRTDIPSVVEKYMNKELELEKFITHKVPFSEINKAFEYMLKGEGLRCIIRMEE
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a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH a secondary alcohol + NAD(+) = a ketone + H(+) + NADH Binds 2 Zn(2+) ions per subunit. Homodimer. Belongs to the zinc-containing alcohol dehydrogenase family.
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Q8GIX7
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MKAAVLHEFGQSLQIEEVDIPTPGAGEIVVKMQASGVCHTDLHAVEGDWPVKPSPPFIPGHEGVGLITAVGEGVTHVKEGDRVGVAWLYSACGHCTHCLGGWETLCESQQNSGYSVNGSFAEYVLANANYVGIIPESVDSIEIAPVLCAGVTVYKGLKMTDTKPGDWVVISGIGGLGHMAVQYAIAMGLNVAAVDIDDDKLAFAKKLGAKVTVNAKNTDPAEYLQKEIGGAHGALVTAVSAKAFDQALSMLRRGGTLVCNGLPPGDFPVSIFDTVLNGITIRGSIVGTRLDLQESLDMAAAGKVKATVTAEPLENINDIFERMRQGKIEGRIVIDYTM
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Psychrophilic alcohol dehydrogenase that exhibits a wide range of substrate specificity, oxidizing mainly primary and secondary aliphatic alcohols, utilizing NAD(+) as a cosubstrate. In vitro, shows highest reaction rates for ethanol as a substrate and gradually decreases its reaction rates as the length and branching of the carbon chain of the alcohol substrates increase. To a lesser extent, is also able to reduce aldehydes and ketones. Do not catalyze the further oxidation of aldehydes to carboxylic acids. Cannot use NADP(+) instead of NAD(+). a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH a secondary alcohol + NAD(+) = a ketone + H(+) + NADH ethanol + NAD(+) = acetaldehyde + H(+) + NADH 1-propanol + NAD(+) = H(+) + NADH + propanal butan-1-ol + NAD(+) = butanal + H(+) + NADH NAD(+) + propan-2-ol = acetone + H(+) + NADH Binds 2 Zn(2+) ions per subunit. One metal ion is located at the active-site region and has been termed catalytic, while the second metal ion has been termed structural. kcat is 549.1 min(-1) for the oxidation of ethanol (at pH 7.4 and 30 degrees Celsius). kcat is 488.8 min(-1) for the oxidation of propan-1-ol (at pH 7.4 and 30 degrees Celsius). kcat is 486.7 min(-1) for the oxidation of butan-1-ol (at pH 7.4 and 30 degrees Celsius). kcat is 382.7 min(-1) for the oxidation of propan-2-ol (at pH 7.4 and 30 degrees Celsius). kcat is 409.8 min(-1) for the reduction of acetone (at pH 6.0 and 30 degrees Celsius) (PubMed:9660191). kcat is 9.4 sec(-1) for the oxidation of ethanol (at pH 7.4 and 30 degrees Celsius) (PubMed:32596590). Optimum pH is 7.4 and 6.0 for the oxidation of ethanol and reduction of acetone, respectively. Is a very thermostable, cold-adapted enzyme. Is active from 10 to at least 53 degrees Celsius and unfolds at 89 degrees Celsius. Homotetramer. Each subunit comprises two distinct structural domains: the catalytic domain (residues 1-150 and 288-340/345) and the nucleotide-binding domain (residues 151-287). Belongs to the zinc-containing alcohol dehydrogenase family. The protein characterized in PubMed:9660191 corresponds to this sequence and not to the fragment sequence described in this article.
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P75214
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MKAYAMLKIGATGWIEKPRPVCGPNDAIIRPLAVAPCTSDVHTVWEGGIGERHNMVLGHEGCGVVDEVGSEVKSFKVGDRVLVAAITPEWNSVNAQAGYPMHSGGMLGGWKFSNVKDGMFAEYFHVNDAEGNLALMPEGMDLADACMLSDMIPTGFHANELADIQYGVALSFFCAGPVGLMAIAGAALKGAGRIIVVDSRPDIVEIAKAYGATDYIDFKKVSVVDEILKWTNNEGVEKVLISGGGSTILETAIKVLRPGGKIGNVNYFGAGEFLTIPRVEWGVGMAHKAIHGGLMLGGRLRLEKLARLIMTKKLDPSKMITHRFKGFEHIEEALFLMKDKPKDLIKSVVIF
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Alcohol dehydrogenase with a preference for medium chain secondary alcohols, such as 2-butanol and isopropanol. Has very low activity with primary alcohols, such as ethanol. Under physiological conditions, the enzyme reduces aldehydes and 2-ketones to produce secondary alcohols. Is also active with acetaldehyde and propionaldehyde (By similarity). NADP(+) + propan-2-ol = acetone + H(+) + NADPH Binds 1 zinc ion per subunit. Belongs to the zinc-containing alcohol dehydrogenase family.
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Q7D8B6
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MSDGAVVRALVLEAPRRLVVRQYRLPRIGDDDALVRVEACGLCGTDHEQYTGELAGGFAFVPGHETVGTIAAIGPRAEQRWGVSAGDRVAVEVFQSCRQCANCRGGEYRRCVRHGLADMYGFIPVDREPGLWGGYAEYQYLAPDSMVLRVAGDLSPEVATLFNPLGAGIRWGVTIPETKPGDVVAVLGPGIRGLCAAAAAKGAGAGFVMVTGLGPRDADRLALAAQFGADLAVDVAIDDPVAALTEQTGGLADVVVDVTAKAPAAFAQAIALARPAGTVVVAGTRGVGSGAPGFSPDVVVFKELRVLGALGVDATAYRAALDLLVSGRYPFASLPRRCVRLEGAEDLLATMAGERDGVPPIHGVLTP
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a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH a secondary alcohol + NAD(+) = a ketone + H(+) + NADH Binds 2 Zn(2+) ions per subunit. Was identified as a high-confidence drug target. Belongs to the zinc-containing alcohol dehydrogenase family.
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O74076
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MRAVRLVEIGKPLSLQEIGVPKPKGPQVLIKVEAAGVCHSDVHMRQGRFGNLRIVEDLGVKLPVTLGHEIAGKIEEVGDEVVGYSKGDLVAVNPWQGEGNCYYCRIGEEHLCDSPRWLGINFDGAYAEYVIVPHYKYMYKLRRLNAVEAAPLTCSGITTYRAVRKASLDPTKTLLVVGAGGGLGTMAVQIAKAVSGATIIGVDVREEAVEAAKRAGADYVINASMQDPLAEIRRITESKGVDAVIDLNNSEKTLSVYPKALAKQGKYVMVGLFGADLHYHAPLITLSEIQFVGSLVGNQSDFLGIMRLAEAGKVKPMITKTMKLEEANEAIDNLENFKAIGRQVLIP
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a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH a secondary alcohol + NAD(+) = a ketone + H(+) + NADH Binds 2 Zn(2+) ions per subunit. Homodimer and homotetramer. Belongs to the zinc-containing alcohol dehydrogenase family.
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P25988
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MCIAGKNIIFVAGLGGIGLDTNREIVKSGPKNLVILDRIENPAAIAELQAINPNVTVSFYPYDVTVALAESVKLLKTIFAKLKTVDLLVNGAGILDDHQIERTIAVNFTGTVNTTTAIMEFWDKRKGGPGGVIANICSVTGFNSIYQVPVYSASKAAALSFTSSLARLAPITGVTVYSINPGITDTTLVHKFNSWLDVEPRVAEKLLAFPTQTSLACAKNFVRAIEANKNGAIWKLDLNRLDEIEWTKHWDSGI
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a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH a secondary alcohol + NAD(+) = a ketone + H(+) + NADH Homodimer. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
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Q00670
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MFIAGKNIIFVAGLGGIGLETSREIVKSGPKNLVILDRAPNPAAIAELQALNPKVTVSFYLYDVTVPQSETVKLLKTIFAKLKTIDLLINGAGILDDHQIERTIAVNFTGTVNTTTAIMEFWDKRKGGPGGVVANICSVTGFNSIYQVPVYSASKAAALSFTSSIAKLATITGVTVYSINPGITDTTLVHKFNSWLDVEPHVAEKLLAFPTQTSLACAKNFVKAIEANKNGAIWKLDLGRLDEIEWTKHWDSGI
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a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH a secondary alcohol + NAD(+) = a ketone + H(+) + NADH Homodimer. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
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Q9URT7
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MTIPDKQLAAVFHTHGGPENVKFEEVPVAEPGQDEVLVNIKYTGVCHTDLHALQGDWPLPAKMPLIGGHEGAGVVVKVGAGVTRLKIGDRVGVKWMNSSCGNCEYCMKAEETICPHIQLSGYTVDGTFQHYCIANATHATIIPESVPLEVAAPIMCAGITCYRALKESKVGPGEWICIPGAGGGLGHLAVQYAKAMAMRVVAIDTGDDKAELVKSFGAEVFLDFKKEADMIEAVKAATNGGAHGTLVLSTSPKSYEQAAGFARPGSTMVTVSMPAGAKLGADIFWLTVKMLKICGSHVGNRIDSIEALEYVSRGLVKPYYKVQPFSTLPDVYRLMHENKIAGRIVLDLSK
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a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH a secondary alcohol + NAD(+) = a ketone + H(+) + NADH Binds 2 Zn(2+) ions per subunit. Homotetramer. Belongs to the zinc-containing alcohol dehydrogenase family.
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Q2FJ31
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MRAAVVTKDHKVSIEDKKLRALKPGEALVQTEYCGVCHTDLHVKNADFGDVTGVTLGHEGIGKVIEVAEDVESLKIGDRVSIAWMFESCGRCEYCTTGRETLCRSVKNAGYTVDGAMAEQVIVTADYAVKVPEKLDPAAASSITCAGVTTYKAVKVSNVKPGQWLGVFGIGGLGNLALQYAKNVMGAKIVAFDINDDKLAFAKELGADAIINSKDVDPVAEVMKLTDNKGLDATVVTSVAKTPFNQAVDVVKAGARVVAVGLPVDKMNLDIPRLVLDGIEVVGSLVGTRQDLREAFEFAAENKVTPKVQLRKLEEINDIFEEMENGTITGRMVIKF
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a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH a secondary alcohol + NAD(+) = a ketone + H(+) + NADH Binds 2 Zn(2+) ions per subunit. Belongs to the zinc-containing alcohol dehydrogenase family.
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Q2G0G1
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MRAAVVTKDHKVSIEDKKLRALKPGEALVQTEYCGVCHTDLHVKNADFGDVTGVTLGHEGIGKVIEVAEDVESLKIGDRVSIAWMFESCGRCEYCTTGRETLCRSVKNAGYTVDGAMAEQVIVTADYAVKVPEKLDPAAASSITCAGVTTYKAVKVSNVKPGQWLGVFGIGGLGNLALQYAKNVMGAKIVAFDINDDKLAFAKELGADAIINSKDVDPVAEVMKLTDNKGLDATVVTSVAKTPFNQAVDVVKAGARVVAVGLPVDKMNLDIPRLVLDGIEVVGSLVGTRQDLREAFEFAAENKVTPKVQLRKLEEINDIFEEMENGTITGRMVIKF
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a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH a secondary alcohol + NAD(+) = a ketone + H(+) + NADH Binds 2 Zn(2+) ions per subunit. Belongs to the zinc-containing alcohol dehydrogenase family.
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Q2YSX0
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MRAAVVTKDHKVSIEDKKLRALKPGEALVQTEYCGVCHTDLHVKNADFGDVTGVTLGHEGIGKVIEVAEDVESLKIGDRVSIAWMFESCGRCEYCTTGRETLCRSVKNAGYTVDGAMAEQVIVTADYAVKVPEKLDPAAASSITCAGVTTYKAVKVSNVKPGQWLGVFGIGGLGNLALQYAKNVMGAKIVAFDINDDKLAFAKELGADAIINSKDVDPVAEVMKLTDNKGLDATVVTSVAKTPFNQAVDVVKAGARVVAVGLPVDKMNLDIPRLVLDGIEVVGSLVGTRQDLREAFEFAAENKVTPKVQLRKLEEINDIFEEMENGTITGRMVIKF
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a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH a secondary alcohol + NAD(+) = a ketone + H(+) + NADH Binds 2 Zn(2+) ions per subunit. Belongs to the zinc-containing alcohol dehydrogenase family.
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Q5HI63
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MRAAVVTKDHKVSIEDKKLRALKPGEALVQTEYCGVCHTDLHVKNADFGDVTGVTLGHEGIGKVIEVAEDVESLKIGDRVSIAWMFESCGRCEYCTTGRETLCRSVKNAGYTVDGAMAEQVIVTADYAVKVPEKLDPAAASSITCAGVTTYKAVKVSNVKPGQWLGVFGIGGLGNLALQYAKNVMGAKIVAFDINDDKLAFAKELGADAIINSKDVDPVAEVMKLTDNKGLDATVVTSVAKTPFNQAVDVVKAGARVVAVGLPVDKMNLDIPRLVLDGIEVVGSLVGTRQDLREAFEFAAENKVTPKVQLRKLEEINDIFEEMENGTITGRMVIKF
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a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH a secondary alcohol + NAD(+) = a ketone + H(+) + NADH Binds 2 Zn(2+) ions per subunit. Belongs to the zinc-containing alcohol dehydrogenase family.
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Q99W07
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MRAAVVTKDHKVSIEDKKLRALKPGEALVQTEYCGVCHTDLHVKNADFGDVTGVTLGHEGIGKVIEVAEDVESLKIGDRVSIAWMFESCGRCEYCTTGRETLCRSVKNAGYTVDGAMAEQVIVTADYAVKVPEKLDPAAASSITCAGVTTYKAVKVSNVKPGQWLGVFGIGGLGNLALQYAKNVMGAKIVAFDINDDKLAFAKELGADAIINSKDVDPVAEVMKLTDNKGLDATVVTSVAKTPFNQAVDVVKAGARVVAVGLPVDKMNLDIPRLVLDGIEVVGSLVGTRQDLREAFEFAAENKVTPKVQLRKLEEINDIFEEMEKGTITGRMVIKF
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a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH a secondary alcohol + NAD(+) = a ketone + H(+) + NADH Binds 2 Zn(2+) ions per subunit. Belongs to the zinc-containing alcohol dehydrogenase family.
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I6X235
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MAEHDFETISSETLHTGAIFALRRDQVRMPGGGIVTREVVEHFGAVAIVAMDDNGNIPMVYQYRHTYGRRLWELPAGLLDVAGEPPHLTAARELREEVGLQASTWQVLVDLDTAPGFSDESVRVYLATGLREVGRPEAHHEEADMTMGWYPIAEAARRVLRGEIVNSIAIAGVLAVHAVTTGFAQPRPLDTEWIDRPTAFAARRAER
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Catalyzes the hydrolysis of ADP-ribose (ADPR) to AMP and ribose-5-phosphate. Can also hydrolyze ADP-mannose and ADP-glucose, with lower efficiency. Has weaker activity with NAD, GDP-sugars and UDP-sugars (PubMed:27683242). Also catalyzes the conversion of 8-oxo-dGDP to 8-oxo-dGMP, and 8-oxo-GDP to 8-oxo-GMP. Functions in concert with MutT1 to detoxify 8-oxo-dGTP to 8-oxo-dGMP and may play an important role in supporting cellular growth under oxidative stress (PubMed:23463507). The catalytic efficiency is much higher for the hydrolysis of ADPR than 8-oxo-dGTP, suggesting a more relevant biological role in hydrolysis of ADPR (PubMed:27683242). ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate + 2 H(+) 8-oxo-dGDP + H2O = 8-oxo-dGMP + H(+) + phosphate 8-oxo-GDP + H2O = 8-oxo-GMP + H(+) + phosphate Binds 3 Mg(2+) ions per subunit (PubMed:12906832). Activity is highest with Mn(2+). Can also use Zn(2+) or Co(2+), with lower efficiency (PubMed:27683242). kcat is 14.4 sec(-1) with ADPR as substrate (in the presence of Mg(2+) ions). kcat is 28.9 sec(-1) with ADPR as substrate (in the presence of Mn(2+) ions) (PubMed:27683242). kcat is 0.0164 sec(-1) with 8-oxo-dGDP as substrate (PubMed:23463507). Optimum pH is 8.0. Homodimer. Belongs to the Nudix hydrolase family.
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P41445
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MRNAAGLFMIIEPDKAVLLCARRAYRSANAPAADMNDTFLEKISIPRGHRDCCDAKVYETAVREFVEETGRFFDSAFIYKLPFTLQWKDDGVTYKYLIYVGVVRGNLINVNAKPNTYTVKLLPGTFGNDYRIMLKPRRFNCEIARSLAIVPLNKYFNYMNDKQLITYDYSNYIEFFDFVRSVKARFDNRQLQDFFYATLKKIDNDAPQKLHALRRV
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Plays an important role in virus replication most probably through its hydrolyzing ADP-ribose activity in host cells. May function in viral DNA replication or transcription directly, or by removing toxic substances or metabolic intermediates. ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate + 2 H(+)
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P36651
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MLKPDNLPVTFGKNDVEIIARETLYRGFFSLDLYRFRHRLFNGQMSHEVRREIFERGHAAVLLPFDPVRDEVVLIEQIRIAAYDTSETPWLLEMVAGMIEEGESVEDVARREAIEEAGLIVKRTKPVLSFLASPGGTSERSSIMVGEVDATTASGIHGLADENEDIRVHVVSREQAYQWVEEGKIDNAASVIALQWLQLHHQALKNEWA
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Acts on ADP-mannose and ADP-glucose as well as ADP-ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process (By similarity). ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate + 2 H(+) Binds 3 Mg(2+) ions per subunit. Inhibited by phosphorylated compounds such as AMP, ADP, ATP, 3-phosphoglyceric acid and PPi. Not inhibited by orthophosphate. Activity is high in cells grown in low glucose concentrations and decreases dramatically as glucose concentration increases (By similarity). Homodimer. Belongs to the Nudix hydrolase family. NudF subfamily.
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D6VQB0
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MFLRNVRVISLNSRRLFRTMSTVKGKPEDAKIIEARHVKETSDCKWIGLQKIIYKDPNGKEREWDSAVRTTRSSGGVDGIGILTILKYKDGKPDEILLQKQFRPPVEGVCIEMPAGLIDAGEDIDTAALRELKEETGYSGKIISKSPTVFNDPGFTNTNLCLVTVEVDMSLPENQKPVTQLEDNEFIECFSVELHKFPDEMVKLDQQGYKLDARVQNVAQGILMAKQYHIK
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ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate + 2 H(+) Binds 3 Mg(2+) ions per subunit. Can also accept Mn(2+) ions. Present with 7330 molecules/cell in log phase SD medium. Belongs to the Nudix hydrolase family. NudF subfamily.
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