README.md

metadata

title: DNA Diffusion Slot Machine
emoji: 🧬
colorFrom: green
colorTo: blue
sdk: gradio
sdk_version: 4.44.1
app_file: app.py
pinned: false
license: apache-2.0

DNA-Diffusion Slot Machine 🎰🧬

An interactive web application for generating cell type-specific DNA regulatory sequences using the DNA-Diffusion model from Pinello Lab.

Features

• 🎰 Interactive Slot Machine Interface: Watch 200 slots spin as DNA sequences are generated
• 🧬 Cell Type-Specific: Generate sequences for K562, GM12878, and HepG2 cell lines
• ⚡ Real-time Animation: Visual feedback during sequence generation
• 🎨 Beautiful UI: Retro-futuristic design with smooth animations

Note

This is a demo version running in mock mode. For real DNA sequence generation:

1. Deploy with GPU enabled
2. Install DNA-Diffusion model dependencies
3. Use the full app.py instead of app_spaces.py

Usage

1. Select a cell type (K562, GM12878, or HepG2)
2. Click GENERATE or pull the lever
3. Watch the slots spin!
4. View your generated 200bp regulatory sequence

Citation

If you use this application in your research, please cite:

@article{dnadiffusion2024,
  title={DNA-Diffusion: Leveraging Generative Models for Controlling Chromatin Accessibility and Gene Expression via Synthetic Regulatory Elements},
  author={DaSilva, Lucas Ferreira and Senan, Simon and Patel, Zain Munir and others},
  journal={bioRxiv},
  year={2024},
  doi={10.1101/2024.02.01.578352}
}

Links

• GitHub Repository
• DNA-Diffusion Paper
• Pinello Lab