text
stringlengths
8
5.77M
package com.baeldung.decorator; public abstract class TreeDecorator implements ChristmasTree { private ChristmasTree tree; public TreeDecorator(ChristmasTree tree) { this.tree = tree; } @Override public String decorate() { return tree.decorate(); } }
Our Pursonal Thoughts Welcome to the StrictlyPursonal Outlet! Our Outlet is full of fantastic finds for savvy shoppers. These are preowned, well loved designer handbags with flaws. All of our outlet items are guaranteed authentic, as with all StrictlyPursonal merchandise. This authentic Prada Black Nylon Ruffle Bag is in excellent condition overall. A store sample, it has been handled, but not worn. Please note that the edges of the ruffles are intentionally unfinished; this is not considered a defect or flaw in any way. Black nylon, silver hardware and very soft leather accents with feminine ruffled detail. Lined in black Prada monogram fabric with three sections and one side zippered pocket. The leather handle may be snuggly worn over the shoulder or tucked away for clutch wear. Purchase includes Prada authenticity card and dust bag. Original retail price $1,695.00. Save $1,396.00 with StrictlyPursonal price of $299.00. Final sale. Attention Overseas Buyers: We are pleased to offer our overseas clients a flat shipping fee of $200.00. All overseas shipping is provided by UPS Global with signature requirements; the safest and most reliable method to ensure your bag arrives safely. Outlet Prada Black Nylon Ruffle Convertible Clutch/ Bag $299.00 Retail Price $1,695.00Savings $1,396.00 * Please Note: The original retail prices on our pre-owned handbags do not reflect today's present values. The price of luxury goods have increased tremendously. In the event that we do not know the original retail price, we will offer an estimate, denoted as: E.C.V. (estimated current value).
Curtains(1983) [Brooke Parsons]: Shot in the chest, along with John Vernon, by Samantha Eggar; Linda and John then fall through the window. (Thanks to Dick Hertz and Eric) Emmerdale Farm(2007; I don't know the exact date) [Rosemary King]: Burned to death (off-screen) in a house fire; we learn of her death when a police officer informs her stepchildren. Her ashes are later shipped back to England from America. (The IMDB lists Linda's last appearance on the show as being the Sept. 12, 2007 episode; I don't know how long afterwards the character's death was established.) (Thanks to Brian)
Don't Sit Stand-Out Man holds woman in choke-hold to rob on CCTV CCTV shows a man seen following woman walking down a narrow lane. He is seen grabbing her from behind by the neck. Neighbourhood News Desk/Avi Arya: Police reported that on Sunday a woman was allegedly attacked and her jewellery and mobile phone was stolen by an unidentified man in Shahdara’s Mansarovar Park. Such incident was caught on CCTV Camera installed in a lane of Mansarovar Park. In the Footage man is seen following the woman who was walking down a narrow lane. He was seen grabbing the woman from behind and holding her by the neck. After pinned her down and subsequently managed to steal her mobile phone and jewellery before fleeing, he ran towards the end of the lane where the another man on the motorcycle was waiting for him. The woman later managed to gather herself. Police have registered a case and are probing the matter.
"(Laughs)" "Why is Hyde kissing'Jackie?" "What the hell?" " He's dead!" " Kelso!" "Open, damn it!" "No, they're gettin' away!" "What is wrong with this thing?" "Well, this is against my better judgment, but" "(Clicks)" "Thank you." "Now Hyde's really dead." "Oh!" "That's invisible!" "(Rock Group Singing)" "(Ends)" "(Man Shouts Greeting)" "Donna, we have to stabilize him." "We're gonna need pudding, and lots of it." "Who chooses a chick over a friend?" "Kelso, come on." "Remember when you made me walk home in a blizzard... 'cause you wanted 10 extra minutes to make out with Pam Macy?" "No, but I didn't steal Pam Macy from you." "And you could've played in the snow until we were done." "Kelso, try to look at the facts." "Jackie wanted to get married, so you bailed... so she found someone else, so now she doesn't wanna marry you." "This solves your problem, albeit with an unpleasant twist ending." "No." "I don't care." "I'm kickin' Hyde's ass." "Kelso, Kelso, come on." "You couldn't open my kitchen door." "I mean" "Seriously, think about how this plan usually turns out." "(Groans) That's my eye!" "Nice." "Aah." "My eye!" "(Groaning)" "(Car Radio:" "Rock)" "(Shouting)" "That's my butt print!" "Look at it!" "No two are the same!" "Ow!" "(Crying) My eye!" "Uh, what am I supposed to do?" "He broke the code!" "He's wrong!" "You know what?" "You're right." "He's, like, my oldest friend, and he stabbed me in the back." "So, Kelso, how many things around here have you put your butt on?" "Let's start with what I haven't put my butt on." "Oh, just a moment." "Red, it's somebody about buying the Corvette." "(Grunts)" "Well, Marlin, we've just seen the male of the herd grunt his displeasure." "But what does it mean?" " The grunting indicates aggression, Jim." " Ah!" "Idiots." "I am about to sell something special to me, because we're having another baby." "And to do that, I have to believe... that this child won't turn out a smart-ass!" "Hello." "Yes." "Don't call here again." " Well, what happened?" " The guy sounded like he was eating." "I don't want some fat bastard eating in my car." "Anyway, I'm going to the doctor's this afternoon" "(Singsongy) because I'm pregnant!" "Oh." "Oh." "And you're picking your grandparents up from the airport." "I'm going to tell them that..." "(Singsongy) I'm pregnant!" "They get in from Phoenix at 5:00." "You know, I was hoping when they moved to Arizona, they'd get lost in the desert." " What's wrong with Mrs. Forman's parents?" " Nothing." "They're just" "They're very complicated people who can't be summed up in a couple of words." " Grandma yells, Grandpa drinks." " That pretty much summed it up." "Now, that is not true." "My father is a wonderful man... who just gets a little sleepy." "And my mother, well- fine- is a little remote... which, I have learned through many helpful books... makes it impossible for her to say, "I love you."" "Even if it's the only thing in the world... a sad little girl needs to hear." "And which is why I say it to you every day." "Eric, I love you." " (Kisses) - (Chuckling)" "And you too, Steven." "I love you!" "Oh, yeah." "No, that's okay." "You don't have to" "No, that's all right. (Grunts) Okay, I love you too." "I can't believe that you knew Jackie and Hyde were together and you didn't tell me." "We... barely knew." "Yeah, we knew, but we were in denial... because it's so unnatural." "Like radioactive spiders." "Well, that's true." "I'm" " It's just- How can Hyde do this to me?" " Uh-oh." "It sounds like he knows." " Finally." "What, your mom knew?" "And Fez?" "Fez never knows anything!" "I know." "I'm really coming into my own." "Whatever." "You know, none of this is as bad as Hyde not telling me." "You know what I'm gonna do?" "I'm gonna make him tell me." " How are you gonna do that?" " By outwitting him conversationally." "What a fine game of cat and mouse it will be." "I'm gonna go find an eye patch." " So, what are you gonna say?" " Oh, it'll come to me in the moment." "Don't you think you should plan it out a little?" "Does an astronaut plan out his missions?" "What happens in cat and mouse if the cat is retarded?" "Oh, you just wait and see." "(Clears Throat)" " What's up?" " That's an interesting question, Hyde." "What is up?" " Well, I guess you know about me and Jackie." " Ahh!" "So the battle of wits has begun!" "What battle of wits?" "I admit it." "I've been messin' around with Jackie." "I hate you!" "Ow!" "My eye!" "Thanks again for the dream catchers." "A blind Indian with three fingers made those." "It was quite a thing to watch." "Wow." "I wonder if him being blind... had something to do with the losing the fingers." "Actually, I think they were taken as part of a primitive manhood ritual." "Eric, I kinda like your grandparents." "What were you so worried about?" " Wait for it." " Burt, sweetie, I think that car is trying to pass." " Why don't you move over?" " Oh, he's fine." "Honey, I really think you should move over." " Sweetie, he can go around." " (Shouts) Move!" " I'm moving." " (Tires Squealing)" "And when he saw you guys kissing, he just fell apart." "I mean, it was awful." "And then he ran into the screen door." "Oh, he's just so bad at doors." "Look, if you don't work things out with Kelso... everybody's gonna choose sides, and nobody's gonna be friends anymore." "Well, that's not my fault." "Look, he deserted me." "He broke my heart." " I didn't do anything wrong." " You're dating his best friend!" "You've gotta talk to him." "You owe him an explanation." "(Groans) This is so not the way I wanted to spend the day." "Well, I didn't wanna spend the day... wiping tears and pudding off of Kelso's cheek." "Burt, honey, why don't you come over and sit with us?" "I'm fine here." "We'd really like it if you would sit and join the party." " I'm part of the party right here." " (Shouts) Sit!" "(Sighs)" "So, Burt, you're lookin' fit." "Dry heat and central air." "That's the key." "Uh-huh." "I've even got an air-conditioned garage." "We can go from the house to the car without ever feeling the heat." "Wow." "They literally never have to breathe fresh air." "Wow." "Who needs it?" "Yep." "(Forced Chuckle)" "Well, those are some real nice sandals, Burt." "Hardly ever see those on men." "Also made by the handicapped Indian." "What spirit." "Oh, um, everybody's here." " Here she is." " Hello, Mom, Daddy." "Kitty, tell everyone your wonderful news." "Quick." " I'd really rather not right now, Red." " But that's why we're here." "Yeah, for the love of God, Mom, tell them." " No, I said not right now." " Kitty, they came all this way." " Yeah, come on." " Fine." "You wanna hear the big news?" "The doctor told me I started menopause." "Kitty, language!" " You're not pregnant?" " Nope." "Nope." "Just barren." "Talk about that." "Mom, I'm really sorry." "I know you wanted a baby, but I'm not really sure what to say... mainly because I'm not really sure what menopause is." "Are you-Are you gonna, like, lose your hair?" "Shut up!" "She's not losing anything." "This just means that from time to time" "A woman's body- (Clears Throat) Kitty, explain it to the boy." "I'm just getting some juice." "Hey, Mom, maybe you should talk to Grandma about this." "Now, that's an idea." "I mean, we're just ignoramuses." "Okay, okay." "Scoot." "Is it" " Is it like a lady-parts thing?" "We'll look it up in the World Book." "Oh, those cookies look good." "Well, thanks." "Sorry I made a scene." "Oh, you were just tired." "No, I wasn't just tired." "Mom, I'm having a really hard time here." "Did it hit you this hard too?" " Did what, dear?" " Menopause." "(Chuckles) I never had it." "Mom, everybody has it." "Well, I've always been quite health conscious." "I told you to eat more vegetables." "You cannot expect me to believe that you never went through menopause." " Well, I didn't." " Yes, you did!" "Well, it doesn't matter, because it's not nice to talk about." "Not everything that needs to be talked about has to be nice." "Mom, why don't you ever really talk to me?" "I told you I liked your cookies!" "I'm gonna find your father." "(Shouts) Burt!" "Is she gone?" "You know, that woman is crazy." "Your mother just doesn't know how to talk to people." "If she yells at you... she really means that she's sorry you're upset." "And if she breaks all your golf clubs... she means "happy anniversary."" "Oh, Daddy, I love you." "I love you, punkin, and so does your mother." "(Bea Shouts) Burt!" " You never saw me." " Okay." "Try to get my eye now!" "(Groaning)" "Hyde, get off!" "Not until you calm down." " Ah!" "A wet one!" " (Grunts)" "Fez, I'm gonna get free eventually, and then I'm gonna kick your ass!" "(Grunting)" "Kelso, look, man, we need to settle this." "No, I don't wanna settle this!" "I don't wanna talk about it!" "All I wanna do is pound you so you can feel as bad as I do!" "Fine." "Fair enough." "Go ahead and hit me." "Free shot." "You gonna hit me back?" "No, man." "That's why they call it a free shot." "Oh." "Okay." "Get ready." "Here it comes." "It's comin'." "Get ready." "We're ready." "Do it, fool!" "You know what?" "Forget it." "It's not gonna change anything." "I just" " Forget it." "Look, Kelso..." "I didn't plan for this, but" "Look, I'm sorry, okay?" "I'm" " I'm really sorry." "(Fez, Donna) Aw!" "Would you get bent?" " So what are we gonna do now?" " I'll tell you what you guys are gonna do." "(Clears Throat) You two are gonna shake hands, and you're gonna be done with it." "No." "Come on." "Give it a try." "Shake hands." " I don't wanna." " (Shouts) Shake!" " (Sighs)" " Well, well." "Look who it is." "Uh, look, Michael, I'm glad I found you." " How's your eye?" " What do you care?" "Okay." "Look, Michael, I know we should've told you sooner... but I'm not gonna say I'm sorry... because I wanted you, and you left and broke my heart." "And I like Steven now... so you need to get over it so we can all become friends again." "Apology accepted." "(Scoffs) Here, let me help you." " Ow." "My eye." " Yeah." "Hey." " How you doin'?" " Oh, great." "It's so nice to no longer be a woman." "Kitty, that's not true." "You know, I've been tryin' to think what I could do to- to make you feel better, and I finally came up with something." "I sent your parents home early." "That kinda helps." "I just- I really wanted to be pregnant." "You know what the real kicker is?" "This morning, when we thought you were still pregnant..." "I sold my Corvette." "(Laughing)" "Memorial Day, meningitis" "Okay, here we go." "Menopause." "Good God!" "I didn't think they'd have pictures." "Well, at least they use the word "uterus" a lot." "I could've gone a whole lifetime... without knowing they had a mucus membrane." "Well, you just" "You can't unlearn something like that, you know?" "Oh, no." "Look at the symptoms." ""Temperamental behavior, mood swings, facial hair."" "Uh-oh." "Dad, I think you have menopause." "Hey, Eric, can you hand me a cookie?" "No, I can't reach while I'm driving." " Come on." "Please?" "Just one cookie." " Just wait till I stop." "(Shouts) Cookie!" "You know, Donna, you catch more flies with sugar." "Right, Burt?" "(Snoring)"
Quake hits Solomons, four die A major 8.0 magnitude earthquake has hit the Solomon Islands, reportedly flattening three villages and killing four people. It also caused small tsunami waves to lap Pacific coastlines and emergency sirens to blare evacuation warnings. Solomon Islands Police Commissioner John Lansley said at least four people died. Solomons officials reported two waves hit the western side of Santa Cruz Island, damaging about 50 homes and properties, said George Herming, a spokesman for the prime minister. Australia's earthquake monitoring agency and the Pacific centre said the biggest tsunami wave measured was 91cm high, at Lata, on the main Santa Cruz island of Ndende. Many villagers had moved to higher ground as a precaution, Herming said. Vanuatu and New Caledonia also reported rising sea levels before a region-wide tsunami alert was lifted. Sirens were heard in Fiji. "Chaos in the streets of Suva as everyone tries to avoid the tsunami!!" tweeted Ratu Nemani Tebana from the Fiji capital Suva. The Pacific Tsunami Warning Centre cancelled its regional alert at 1450 AEDT, about two and a half hours after the quake struck. The US Geological Survey said the quake hit the Santa Cruz Islands in Temotu province, which have been rocked by a series of strong tremors over the past week, at a shallow depth of 5.8 kilometres. Temotu is the easternmost province of the Solomons, about a three-hour flight from the capital, Honiara. The region has a population of about 30,000. Two powerful aftershocks of 6.4 and 6.6 magnitude were also recorded. Locals in Honiara, 580 kilometres from the epicentre, said the quake was not felt there. "The information we are getting is that some villages west and south of Lata along the coast have been destroyed, although we cannot confirm this yet," the director of nursing at Lata Hospital told AFP. "There was continuous shaking in Lata but no damaged buildings here," he added. The ABC quoted emergency service authorities in the Solomons as saying three villages were destroyed by the quake. Officials could not be reached for confirmation, with phone lines down. Hospital director Augustine Bilve said patients were being evacuated to prepare for any injured from the villages along the coast. "We were told that after the shaking, waves came to the villages. So far, we are waiting in Lata and are evacuating patients in case there are any casualties." A staff member at the Solomons National Disaster Management Office said officials were concerned about Temotu. Before it was lifted, the Pacific centre's tsunami warning was in effect for the Solomon Islands, Vanuatu, Nauru, Papua New Guinea, Tuvalu, New Caledonia, Kosrae, Fiji, Kiribati, and Wallis and Futuna. In 2007, a tsunami following an 8.0-magnitude earthquake killed at least 52 people in the Solomons and left thousands homeless. The quake was so powerful it lifted an island and pushed out its shoreline by dozens of metres. The Solomon Islands are part of the "Ring of Fire", a zone of tectonic activity around the Pacific Ocean that is subject to earthquakes and volcanic eruptions. AFP/AP This material is subject to copyright and any unauthorised use, copying or mirroring is prohibited.
Q: How could a microwave launch a cup? This is something that's puzzled me for years and I'm hoping someone here can offer a theoretical explanation and put my curiosity about it to rest. About 15 years ago in my bachelor days I wasn't so good about putting my dishes away and left a clean, empty plastic drinking glass on top of my microwave (which sat on top of my counter) undisturbed for weeks. The glass was made of thick heavy-duty translucent plastic and gave the cup some heft. One day when I was cooking something in the microwave I heard a distinct pop and saw the cup fly off the microwave--it fly up a few inches to maybe a foot and landed on the floor. What physical phenomena could have caused this? Static buildup and sudden discharge? Spring loading of the metal body of the microwave and sudden release? Heating of air under the cup (it had a small void underneath with a uniform lip that would have trapped some air)? Something else? I no longer own the microwave or the cup so I can't say for sure the microwave wasn't defective in some way, nor can I conduct experiments. A: If was a heavy cup, I would be inclined to rule out trapped air. The larger the volume of air available to act as "thrust", implies the cup was bigger, and so heavier, so I guess that's not it. A faulty microwave might shake, or if the rotating plate "fell" into it's turntable slot position, as the rotation continued, it might have shaken the machine. The cup could have been located over the air vent, (which manufacturers do locate on the top) and gathered enough hot air to lift off. But the most likely option imo, is the sudden flexing of the machine roof, which might have heated up enough. I think microwaves ovens get hot enough for this and it would be my best guess. They are tightly fitting casings, so it may act as a mini drumhead, that is fairly tense in the first place, then heated air gets trapped below it, and the top of the oven springs upwards to release the pressure.
TrilobiteAsaphus Punctatus. TRI r03 Wolchow River, St. Petersburg, Russia. Ordovician 450 million years old Specimen is 55x50x25mm. Trilobite is 55x30mm.Aust. $375.00All sizes are approximate This is a one only fossil, it may not be available. If you require a fossil bigger or smaller than the feature please e-mail us with your request. TrilobiteAsaphus Plautini. TRI r11 Wolchow River, St. Petersburg, Russia. Ordovician 450 million years old Specimen is 125x110x25mm. Trilobite is 65x45mm.Aust. $225.00All sizes are approximate This is a one only fossil, it may not be available. If you require a fossil bigger or smaller than the feature please e-mail us with your request. TrilobiteAsaphus Plautini. TRI r09 Wolchow River, St. Petersburg, Russia. Ordovician 450 million years old Specimen is 105x60x30mm. Trilobite is 70x40mm.Aust. $350.00All sizes are approximate This is a one only fossil, it may not be available. If you require a fossil bigger or smaller than the feature please e-mail us with your request. TrilobiteAsaphus Cornutus. TRI r05 Wolchow River, St. Petersburg, Russia. Ordovician 450 million years old Specimen is 85x55x25mm. Trilobite is 45x35mm.Aust. $265.00All sizes are approximate This is a one only fossil, it may not be available. If you require a fossil bigger or smaller than the feature please e-mail us with your request. TrilobiteAsaphus Cornutus. TRI r04 Wolchow River, St. Petersburg, Russia. Ordovician 450 million years old Specimen is 85x75x40mm. Trilobite is 35x35mm.Aust. $350.00All sizes are approximate This is a one only fossil, it may not be available. If you require a fossil bigger or smaller than the feature please e-mail us with your request. TrilobiteAsaphus Kowalewski. TRI r13 Wolchow River, St. Petersburg, Russia. Ordovician 450 million years old Specimen is 66x60mm. Trilobite is 48x31mm.Sorry, Sold.All sizes are approximate This is a one only fossil, it may not be available. If you require a fossil bigger or smaller than the feature please e-mail us with your request. TrilobiteIllaneus punctatus. TRI r02 Wolchow River, St. Petersburg, Russia. Ordovician 450 million years old Specimen is 75x65x45mm. Trilobite is 30x30mm.Sorry, Sold.Please ask if you would like us to get you one like thisAll sizes are approximate This is a one only fossil, it may not be available. If you require a fossil bigger or smaller than the feature please e-mail us with your request.
Effects of Copper on Root Morphology, Cations Accumulation, and Oxidative Stress of Grapevine Seedlings. In the present study, a hydroponic experiment was conducted to investigate the oxidative stress and the copper (Cu) accumulation in grapevines exposed to three Cu levels (0, 5, and 15 µM) for 1, 2, and 3 days. The results showed that the root elongation was stunted at the highest-exposure concentration. The Cu accumulation in the grapevines increased with increasing Cu treatments, while the other nutrient elements (Ca, Mg and K) absorbed by the grapevines decreased. Most of the Cu taken up by the grapevines was accumulated in the roots. Compared to the data for 1 day after treatment, the Cu-addition significantly decreased the Mg and K concentration in the roots and leaves, yet increased the superoxide dismutase activity in the leaves after 3 days of treatment. For the reactive oxygen species, the malondialdehyde increased with increasing Cu levels in the roots and leaves; however, both the Cu-addition and exposure duration reduced the H2O2 level in the root. Additionally, the Cu-induced accumulation of ·O2- and H2O2 in the grapevine leaves can be observed by the histochemical staining of nitroblue tetrazolium and diaminobenzidine, respectively. In conclusion, the present results indicate that excess Cu results in a change of the root morphology and leads to oxidative stress for the grapevine leaves and roots.
/* toy vm register A, B : 32bit PC : program counter mem_ 4byte x 65536 すべての命令は4byte固定 即値は全て16bit R = A or B vldiR, imm ; R = imm vldR, idx ; R = mem_[idx] vstR, idx ; mem_[idx] = R vaddiR, imm ; R += imm vsubiR, imm ; R -= imm vaddR, idx ; R += mem_[idx] vsubR, idx ; R -= mem_[idx] vputR ; print R vjnzR, offset; if (R != 0) then jmp(PC += offset(signed)) */ #if defined(_MSC_VER) && (_MSC_VER <= 1200) #pragma warning(disable:4514) #pragma warning(disable:4786) #endif #include <stdio.h> #include <stdlib.h> #include <memory.h> #include <vector> #define XBYAK_NO_OP_NAMES #include "xbyak/xbyak.h" #include "xbyak/xbyak_util.h" #define NUM_OF_ARRAY(x) (sizeof(x) / sizeof(x[0])) #ifdef XBYAK64 #error "only 32bit" #endif using namespace Xbyak; class ToyVm : public Xbyak::CodeGenerator { typedef std::vector<uint32_t> Buffer; public: enum Reg { A, B }; enum Code { LD, LDI, ST, ADD, ADDI, SUB, SUBI, PUT, JNZ, END_OF_CODE }; ToyVm() : mark_(0) { ::memset(mem_, 0, sizeof(mem_)); } void vldi(Reg r, uint16_t imm) { encode(LDI, r, imm); } void vld(Reg r, uint16_t idx) { encode(LD, r, idx); } void vst(Reg r, uint16_t idx) { encode(ST, r, idx); } void vadd(Reg r, uint16_t idx) { encode(ADD, r, idx); } void vaddi(Reg r, uint16_t imm) { encode(ADDI, r, imm); } void vsub(Reg r, uint16_t idx) { encode(SUB, r, idx); } void vsubi(Reg r, uint16_t imm) { encode(SUBI, r, imm); } void vjnz(Reg r, int offset) { encode(JNZ, r, static_cast<uint16_t>(offset)); } void vput(Reg r) { encode(PUT, r); } void setMark() { mark_ = (int)code_.size(); } int getMarkOffset() { return mark_ - (int)code_.size() - 1; } void run() { bool debug = false;//true; uint32_t reg[2] = { 0, 0 }; const size_t end = code_.size(); uint32_t pc = 0; for (;;) { uint32_t x = code_[pc]; uint32_t code, r, imm; decode(code, r, imm, x); if (debug) { printf("---\n"); printf("A %08x B %08x\n", reg[0], reg[1]); printf("mem_[] = %08x %08x %08x\n", mem_[0], mem_[1], mem_[2]); printf("pc=%4d, code=%02x, r=%d, imm=%04x\n", pc, code, r, imm); } switch (code) { case LDI: reg[r] = imm; break; case LD: reg[r] = mem_[imm]; break; case ST: mem_[imm] = reg[r]; break; case ADD: reg[r] += mem_[imm]; break; case ADDI: reg[r] += imm; break; case SUB: reg[r] -= mem_[imm]; break; case SUBI: reg[r] -= imm; break; case PUT: printf("%c %8d(0x%08x)\n", 'A' + r, reg[r], reg[r]); break; case JNZ: if (reg[r] != 0) pc += static_cast<signed short>(imm); break; default: assert(0); break; } pc++; if (pc >= end) break; } // for (;;) } void recompile() { using namespace Xbyak; /* esi : A edi : B ebx : mem_ for speed up mem_[0] : eax mem_[1] : ecx mem_[2] : edx */ push(ebx); push(esi); push(edi); const Reg32 reg[2] = { esi, edi }; const Reg32 mem(ebx); const Reg32 memTbl[] = { eax, ecx, edx }; const size_t memTblNum = NUM_OF_ARRAY(memTbl); for (size_t i = 0; i < memTblNum; i++) xor_(memTbl[i], memTbl[i]); xor_(esi, esi); xor_(edi, edi); mov(mem, (size_t)mem_); const size_t end = code_.size(); uint32_t pc = 0; uint32_t labelNum = 0; for (;;) { uint32_t x = code_[pc]; uint32_t code, r, imm; decode(code, r, imm, x); L(Label::toStr(labelNum++)); switch (code) { case LDI: mov(reg[r], imm); break; case LD: if (imm < memTblNum) { mov(reg[r], memTbl[imm]); } else { mov(reg[r], ptr[mem + imm * 4]); } break; case ST: if (imm < memTblNum) { mov(memTbl[imm], reg[r]); } else { mov(ptr [mem + imm * 4], reg[r]); } break; case ADD: if (imm < memTblNum) { add(reg[r], memTbl[imm]); } else { add(reg[r], ptr [mem + imm * 4]); } break; case ADDI: add(reg[r], imm); break; case SUB: if (imm < memTblNum) { sub(reg[r], memTbl[imm]); } else { sub(reg[r], ptr [mem + imm * 4]); } break; case SUBI: sub(reg[r], imm); break; case PUT: { static const char *str = "%c %8d(0x%08x)\n"; push(eax); push(edx); push(ecx); push(reg[r]); push(reg[r]); push('A' + r); push((int)str); call(reinterpret_cast<const void*>(printf)); add(esp, 4 * 4); pop(ecx); pop(edx); pop(eax); } break; case JNZ: test(reg[r], reg[r]); jnz(Label::toStr(labelNum + static_cast<signed short>(imm))); break; default: assert(0); break; } pc++; if (pc >= end) break; } // for (;;) pop(edi); pop(esi); pop(ebx); ret(); } private: uint32_t mem_[65536]; Buffer code_; int mark_; void decode(uint32_t& code, uint32_t& r, uint32_t& imm, uint32_t x) { code = x >> 24; r = (x >> 16) & 0xff; imm = x & 0xffff; } void encode(Code code, Reg r, uint16_t imm = 0) { uint32_t x = (code << 24) | (r << 16) | imm; code_.push_back(x); } }; class Fib : public ToyVm { public: Fib(int n) { if (n >= 65536) { fprintf(stderr, "current version support only imm16\n"); return; } /* A : c B : temporary mem_[0] : p mem_[1] : t mem_[2] : n */ vldi(A, 1); // c vst(A, 0); // p(1) vldi(B, static_cast<uint16_t>(n)); vst(B, 2); // n // lp setMark(); vst(A, 1); // t = c vadd(A, 0); // c += p vld(B, 1); vst(B, 0); // p = t // vput(A); vld(B, 2); vsubi(B, 1); vst(B, 2); // n-- vjnz(B, getMarkOffset()); vput(A); } void runByJIT() { getCode<void (*)()>(); } }; void fibC(uint32_t n) { uint32_t p, c, t; p = 1; c = 1; lp: t = c; c += p; p = t; n--; if (n != 0) goto lp; printf("c=%d(0x%08x)\n", c, c); } int main() { try { const int n = 10000; Fib fib(n); fib.recompile(); { Xbyak::util::Clock clk; clk.begin(); fib.run(); clk.end(); printf("vm %.2fKclk\n", clk.getClock() * 1e-3); } { Xbyak::util::Clock clk; clk.begin(); fib.runByJIT(); clk.end(); printf("jit %.2fKclk\n", clk.getClock() * 1e-3); } { Xbyak::util::Clock clk; clk.begin(); fibC(n); clk.end(); printf("native C %.2fKclk\n", clk.getClock() * 1e-3); } } catch (std::exception& e) { printf("ERR:%s\n", e.what()); } catch (...) { printf("unknown error\n"); } return 0; } /* the code generated by Xbyak push ebx push esi push edi xor eax,eax xor ecx,ecx xor edx,edx xor esi,esi xor edi,edi mov ebx,0EFF58h mov esi,1 mov eax,esi mov edi,2710h mov edx,edi .lp: mov ecx,esi add esi,eax mov edi,ecx mov eax,edi mov edi,edx sub edi,1 mov edx,edi test edi,edi jne .lp push eax push edx push ecx push esi push esi push 41h push 42C434h call printf (409342h) add esp,10h pop ecx pop edx pop eax pop edi pop esi pop ebx ret */
Resource Collection The Women's Center offers a library collection of extensive material concerning Women's Studies and multicultural literature, including books, reports, fact sheets, articles, videos and a variety of pamphlets. We can provide individualized assistance on research projects. Books are available for a two-week check out period. Crisis Intervention Counseling The Women's Center provides confidential counseling for anyone in need of assistance with a crisis, problem, or issue. The staff members are available to listen and discuss any concerns you may have. We are here to identify options and provide any information or referrals you may need. Safer Sex Supplies The Women's Center sells safer sex supplies to promote responsible intimacy. We sell assorted condoms for 10¢, lubricant packets for 10¢, and dental dams for 25¢ each! The condoms and dental dams are available in a variety of flavors including strawberry, banana, mint and vanilla. Advocacy The Women’s Center Coordinator serves as an advocate for all students, faculty, and staff in regard to discrimination, harassment, assault, or violence. The Coordinator provides confidential assistance and supports all individuals in filing a complaint or utilizing the college judicial/grievance system. Educational Programs The Women's Center organizes workshops and hosts speakers to enrich your college experience. We sponsor educational campaigns on a variety of issues such as body image, relationship violence, and more. We also offer assistance to RAs and all student clubs and organizations in designing programs, and sponsor special events for Women Studies minors. Let us know what programs you would like to see, or better yet, let us help you plan one! Queer Peer Services Coordinator The Queer Peer Services Coordinator is a staff member who provides peer counseling and advocacy for students who identify as gay, lesbian, bisexual, or transsexual as well as students who may be questioning and/or struggling with their sexual identity. Other services include a resource collection on LGBT issues and educational programs on sexual identity. Men's Outreach Coordinator The Men's Outreach Coordinator (MOC) works with men on campus about issues such as sexual assault and violence prevention, the meaning of masculinity, healthy relationships, gender stereotypes, and media images through group and individual settings. Club Meeting Place There are many clubs and organizations that meet in the Women’s Center, including Ramapo Pride (a Gay/Straight Alliance), Feminists United, Ramapo Students Against the War, Catholic Women at Ramapo, and the Body Image Support Group. Come in to find out this semester’s meeting days and times!
Aarakshan, a star-filled Bollywood film on India's caste system, churned up passionate debate as it opened Friday, with angry lower caste groups trying to torpedo its release, saying it reinforces social prejudices against them. The furor makes clear that caste — the millennia-old Hindu custom that divides people in a strict social hierarchy based on their family's traditional livelihood and ethnicity — remains a deeply sensitive subject in modern India, despite government programs to erase such distinctions. At least three big states have banned Aarakshan from opening on schedule Friday over fears it could stir up caste tensions. Its director, Prakash Jha, filed an urgent appeal to India's Supreme Court seeking to overturn the bans. The film's stars were given police bodyguards, and police also guarded theatres that did show the film, searching moviegoers and barring them from bringing bags inside, authorities said. The movie's title means "reservation," a reference to affirmative action quotas for India's untouchables, also known as dalits, in jobs and education. Dalits, who form nearly a fourth of India's billion-plus population, say the film belittles them and shows them in a negative light. Filmmaker agrees to edits Jha disputed their interpretation of his movie, but he agreed to edit out parts they may find offensive. The edited version, however, was not available as it opened across the country over this lucrative Independence Day three-day weekend. The film's star, famed actor Amitabh Bachchan, sounded anguished on his Twitter account Friday, accusing people of condemning the film without even watching it. A Bahujan Samaj Party activist beats a burnt poster of Bollywood icon Amitabh Bachchan, among the stars of the controversial new film Aarakshan, or Reservation, in Mumbai on Thursday (Associated Press) "Have cried at our helplessness in not making people understand that this art needs to be seen not banned!" he tweeted. On his blog, Bachchan quoted his character in the film, the principal of a college: "Two Indias reside in this country ... and in truth, if we have to see any progress in our society, then the distance between these two Indias must be erased." Caste discrimination runs deep in India despite government efforts since independence in 1947 to use affirmative action to wipe it out. India's economic boom has further sharpened the divide, with much of its dividends accruing to the upper castes. Nevertheless, large sections of India's upper castes are incensed over the quota policy, which ensures lower castes get spaces in the country's highly sought-after medical and engineering schools, universities and jobs. Aarakshan had created a buzz, with the films lead actors — also including action hero Saif Ali Khan and Bollywood starlet Deepika Padukone — travelling the country to promote its release. In the film, Bachchan plays the idealistic head of a college who ends up being pushed out amid tensions between dalit and upper caste students over the quota system. Another objection raised by some lower caste groups is the casting of Khan, who belongs to one of the royal families that previously ruled parts of India, as the Dalit protagonist. "This objection is unfair. By this logic, are they saying a Dalit cannot play the role of a king in a film?" asks Jha. Banned in 3 states With dalit groups saying the film is biased against the quota system, the government of Uttar Pradesh, India's biggest state, banned the film Wednesday. A day later, the governments of Punjab and Andhra Pradesh followed suit. The ban could cost the film more than 150 million rupees (nearly $3.3 million Cdn) in earnings, as filmgoers were expected to crowd theatres over the long weekend, trade analysts said. A government panel for the welfare of lower castes also has asked the country's film authorities to review the clearance given to the film. "We have written to the Censor Board to review the film and remove at least five objectionable dialogues from the movie," said P. L. Punia, who heads the panel. "These changes can be made without affecting the narrative of the film." Meanwhile, the Mumbai film fraternity is closing ranks in support of the movie. "There is nothing objectionable in the film. When people see it, they will realize that there is nothing controversial," said Ajay Devgn, a leading Bollywood action star.
Apple is offering partial refunds to recent iCloud subscribers as it drops the price of its cloud storage plans. The refunds were first reported by Circa editor Nicholas Deleon, who received an e-mail from Apple about refunds to his personal iCloud account. Deleon had been paying $40 per year for 25 GB of storage, but will start paying $12 per year on October 10. To cover the price difference between now and then, Apple is giving Deleon a prorated refund of $2.38. Apple's iCloud storage plans previously included 5 GB of free data and cost $20 per year for an extra 10 GB, $40 per year for 20 GB, and $100 per year for 50 GB. As of Tuesday, Apple's new storage plans cost $1 per month for 20 GB, $4 per month for 200 GB, $10 per month for 500 GB and $20 per month for 1 TB. All users will still get 5 GB of data for free. The new plans coincide with big changes in how iCloud deals with photos and data. Instead of pushing Photo Stream as the main way to wirelessly sync all photos across devices, Apple will offer an “iCloud Photo Library” that stores everything online and lets users download only the photos they want to new devices. Unlike with Photo Stream, the Photo Library won't limit syncing to your last 1000 images, but it will require you to buy more storage if you reach the free 5 GB limit. At the same time, Apple will offer a tool called iCloud Drive, which lets users manage all their online files, including photos, documents and app data. It's similar to true cloud storage programs like Dropbox and Google Drive, and it'll work with both Windows PCs and Macs. The change should make users' cloud storage less opaque and easier to manage directly. Just keep in mind that while Apple has dropped the price of its cloud storage plans, other competing services are still much cheaper. Google Drive and Dropbox both offer 1 TB of storage for $10 per month, and Microsoft offers 1 TB as part of an Office 365 subscription starting at $70 per year. All three services allow you to automatically upload photos and videos from an iPhone through their respective mobile apps.
The human UDP-glucuronosyltransferase UGT1A3 is highly selective towards N2 in the tetrazole ring of losartan, candesartan, and zolarsartan. Losartan, candesartan, and zolarsartan are AT(1) receptor antagonists that inhibit the effect of angiotensin II. We have examined their glucuronidation by liver microsomes from several animals and by recombinant human UDP-glucuronosyltransferases (UGTs). Large differences in the production of different glucuronide regioisomers of the three sartans were observed among liver microsomes from human (HLM), rabbit, rat, pig, moose, and bovine. However, all the liver microsomes produced one or two N-glucuronides in which either N1 or N2 of the tetrazole ring were conjugated. O-Glucuronides were also detected, including acyl glucuronides of zolarsartan and candesartan. Examination of individual human UGTs of subfamilies 1A and 2B revealed that N-glucuronidation activity is widespread, along with variable regioselectivity with respect to the tetrazole nitrogens of these sartans. Interestingly, UGT1A3 exhibited a strong regioselectivity towards the N2 position of the tetrazole ring in all three sartans. Moreover, the tetrazole-N2 of zolarsartan was only conjugated by UGT1A3, whereas the tetrazole-N1 of this aglycone was accessible to other enzymes, including UGT1A5. Zolarsartan O-glucuronide was mainly produced by UGTs 1A10 and 2B7. UGT2B7, alongside UGT1A3, glucuronidated candesartan at the tetrazole-N2 position, whereas UGTs 1A7-1A10 mainly yielded candesartan O-glucuronide. In the case of losartan, no O-glucuronide was generated by any tested human enzyme. Nevertheless, UGTs 1A1, 1A3, 1A10, 2B7, and 2B17 glucuronidated losartan at the tetrazole-N2, while UGT1A10 also yielded the respective N1-glucuronide. Kinetic analyses revealed that the main contributors to losartan glucuronidation in HLM are UGT1A1 and UGT2B7. The results provide ample new data on substrate specificity in drug glucuronidation.
Guillain-Barré syndrome in a child with systemic lupus erythematosus and anti-Ro/SSA and anti-La/SSB autoantibodies. We report a 9-year follow-up of a girl with systemic lupus erythematosus (SLE) and probable Sjögren's syndrome. At the age of 7 years, the patient developed a chilblain-like eruption with features of SLE, including leucopenia, oral ulcers, positive rheumatoid and antinuclear antibodies and positive anti-dsDNA, anti-Ro/SSA and anti-La/SSB antibodies. At the age of 13 years she developed Guillain-Barré syndrome, which completely resolved with aggressive treatment, including high-dose corticosteroids and the use of plasma exchange followed by intravenous gammaglobulin.
Saturday, June 21, 2014 Cheddar Dill Biscuits Holy moly, these taste pretty darn close to those addicting biscuits they serve you at a certain popular chain seafood restaurant. Know the one I'm talking about? A few nights back I threw together some pasta for dinner {which ended up being nothing to rave about} and instead of doing the typical garlic bread as a side, I made these biscuits. Which in turn, were something to rave about. In fact every day since then I have been warming one up in the microwave for an afternoon snack and then regretting it later while I walk around with dill/garlic breath. You have to pick your battles.  Please do not be intimidated with making biscuits. Unlike bread, no kneading is required, just a little elbow grease to mix in the ingredients together and a floured surface to press the dough down flat and a sharp knife to cut. That's it! I even made these with three kids in the same room as me. I'm pretty sure there was a bit of crying, yelling and bickering with each other going on, but I just turned my back to it all for a few minutes to mix this dough together. Sometimes you just have to let them work it out. Now I know biscuits aren't typically a "summer" side dish, but that doesn't mean you can't make them. I baked mine in my toaster oven so I didn't heat up the kitchen. And like I said prior, they made up for a piss poor pasta dish I made. {It was edible.....just bland and boring}. You win some you lose some. You had better tuck this little gem of a recipe away for the Fall months as well. I can see these working fantastically with a hearty soup, casserole or stew. But I'm not going to think about Fall right now, because lets be honest after the winter we had, I am trying to embrace this glorious summer! Cheddar Dill BiscuitsPrint this Recipe!2 c. flour1 T. baking powder1/2 t. baking soda1 t. garlic salt1 stick, cold, unsalted butter, cubed1 c. shredded cheddar cheese3 T. freshly chopped dill1/2 c. buttermilk or 2% milk2 eggs1 T. water1. Preheat oven to 400 degrees.2. In a large bowl combine dry ingredients. Add butter, and using a pastry cutter, blend into flour mixture until it resembles course crumbs.3. Add cheddar and dill and toss to combine.4. Add in buttermilk or milk, along with 1 egg and combine until just stirred together.5. Sprinkle a work surface with flour and press the dough together until it comes together. Push down to 1/2 inch thickness, forming a large square. Cut into 9 biscuits.6. Place biscuits on a cookie sheet. Combine the remaining egg and water and brush onto the tops of the biscuits.7. Bake 10-12 minutes or until golden brown. Best when served warm!
Preparation of monolithic matrices for oral drug delivery using a supercritical fluid assisted hot melt extrusion process. The use of supercritical fluids as plasticisers in polymer processing has been well documented. The body of work described in this research paper outlines the use of a supercritical CO(2) assisted extrusion process in the preparation of a hot melt extruded monolithic polymer matrix for oral drug delivery. Several batches of matrix material were prepared with Carvedilol used as the active pharmaceutical ingredient (API). These batches were subsequently extruded both with and without supercritical CO(2) incorporation. The resultant matrices were characterised using steady-state parallel plate rheometry, differential scanning calorimetry (DSC), atomic force microscopy (AFM), micro-thermal analysis (microTA) and dissolution testing. Dissolution analysis showed that the use of supercritical CO(2) during the extrusion process resulted in a faster dissolution of API when compared with unassisted extrusion. The supercritical CO(2) incorporation also resulted in reduced viscosity during processing, therefore allowing for quicker throughput and productivity. The results detailed within this paper indicate that supercritical fluid assisted hot melt extrusion is a viable enhancement to conventional hot melt extrusion for the production of monolithic dosage forms.
Hampshire Treasures Page 243 - St Thomas Kent Hall. Circa 1850, T.E. Owen. Three storeys, stucco faced. Low pitch gable end slate roof. Three recessed sash windows to each floor, iron balcony to first floor central window. Entrance to right in two storey extension, with later lattice casement on first floor and two small ground floor windows. Panelled door flanked by broad stucco pilasters. T&C P ActCA SZ 642 9902713 19 HouseC.19 Kent Cottage. Circa 1850, T.E. Owen. Irregular two storey rendered building, with attic and tower block to street. Rusticated ground floor. Three storey tower block has low pitch pyramid slate roof. One window to east and north faces, those under the eaves and on first floor blind to north. Ground floor has recessed sash to east and casement to north. Stepped double gable garden block. Under small gable casement window and panelled door with semi-circular fanlight. Under larger gable casement in architrave surround on first floor. Garden block has low slate roof. T&CP ActCA SZ 642 9902713 20 HouseC.19 Annesley House. Irregular two storey and attic rendered villa. East block taller, with low pitch gable and slate roof, with shaped stucco brackets to overhanging eaves. Rusticated ground floor. First floor has two sash windows with keystones, ground floor has tripartite window with rusticated dividing piers. To the left, slightly lower extension. Wing to the rear is of two storeys with hipped slate roof, and sash windows. Projecting porch to the north with panelled door and rectangular fanlight. T&CP ActCA SZ 641 9902713 21 HouseC.19 Crescent House. 1847. Two storeys stucco faced, Italianate features. Garden front facing road is stepped back in three bays west to east. The first with low pitched gables, slate roofs. Three first floor recessed sash windows in gabled bays with Venetian shutters. Left hand ground floor window has steps to garden. The garden block is followed by a slightly projecting low gabled entrance bay, the gable supported by heavy shaped brackets. Round headed entrance to porch. The third bay has tripartite windows to both floors. T&CP ActCA SZ 643 9912713 22 House Woodend. Circa 1850 villa. Two storeys stuccoed low pitched gable end slate roof. Symmetrical front. Three recessed sash windows to first floor. French windows to left on ground floor, to the right conservatory extends to north. Porch to centre with balustraded parapet.
Characterization of TLR4 signaling in water buffalo (Bubalus bubalis). Lipopolysaccharide (LPS) treatment of Peripheral Blood Mononuclear Cells (PBMC) isolated from the water buffalo resulted in the activation of TLR signaling intermediates as supported by the western blot of pERK. Activation of ERK resulted in phosphorylation of IkappaB-alpha which lead to its degradation which in turn followed by nuclear translocation of NF-kappaB, which is also supported by the western blot analysis. The nuclear translocation of NF-kappaB culminated in the induction of mRNA expression of TNF-alpha. Thus this study demonstrates the TLR signaling in PBMCs of water buffalo which is as similar to that reported earlier in mice and human beings.
... Access your DBMS from Erlang without any line of SQL code ... AMNESIA is an Erlang library providing an abstraction layer for interfacing relational DBMSs. The basic objective is to allow designers to integrate relational database support in Erlang programs using Erlang-native types and language constructs and thus without needing to manage SQL statements and DMBS-specific peculiarities. The main characteristics are following: Easy specification of the structure of a database (tables and links) by means of Erlang-native types and functions. Direct creation of the tables starting from their Erlang specification. Direct use of Erlang records to handle database data. Simple functions for database accessing and data handling. Support for all relational operations (insert, select, join, etc.) by means of proper Erlang functions. AMNESIA is structured by means of a layered architecture. The amnesia module is at the topmost layer and provides the main high-level functions for database access. Then, on the basis of the DBMS chosen for the specific database implemented, the amnesia module contacts the proper amnesia_driver; the latter acts as a bridge between the amnesia layer and the bottom layer (dbms_layer), which provides the real interface to the specific DBMS selected. Currently AMNESIA supports only MySQL, but a driver for PostgreSQL is under development.
Quantum superconductor-insulator transition: implications of BKT critical behavior. We explore the implications of Berezinskii-Kosterlitz-Thouless (BKT) critical behavior on the two-dimensional (2D) quantum superconductor-insulator (QSI) transition driven by the tuning parameter x. Concentrating on the sheet resistance R(x,T) BKT behavior implies: an explicit quantum scaling function for R(x,T) along the superconducting branch ending at the nonuniversal critical value Rc = R(xc); a BKT-transition line T(c)(x) [proportionality] (x - x(c))(zν[overline]), where z is the dynamic exponent and ν[overline] the exponent of the zero-temperature correlation length; independent estimates of zν[overline], z and ν[overline] from the x dependence of the nonuniversal parameters entering the BKT expression for the sheet resistance. To illustrate the potential and the implications of this scenario we analyze the data of Bollinger et al (2011 Nature 472 458) taken on gate voltage tuned epitaxial films of La2-xSrxCuO4 that are one unit cell in thickness. The resulting estimates, z ~/= 3.1 and ν[overline] ~/= 0.52, indicate a clean 2D-QSI critical point where hyperscaling, the proportionality between d/λ(2)(0) and Tc, and the correspondence between the quantum phase transitions in D dimensions and the classical ones in (D + z) dimensions are violated.
Q: SOLVED - boost::interprocess::interprocess_condition::timed_wait() compiler error I'm trying to create some objects in shared memory (which will be a future question) but for now I've getting a compiler error (boost 1.53.0 using g++ 4.8.5 on RHEL 7.8) that I can't figure out. Event.h #include <boost/interprocess/sync/interprocess_condition.hpp> #include <boost/interprocess/sync/interprocess_mutex.hpp> class Event { public: Event (std::string name, boost::interprocess::managed_shared_memory shmem); int SetEvent (); int ResetEvent (); int WaitForEvent (int64_t milliseconds = -1); private: typedef boost::interprocess::allocator<boost::interprocess::basic_string<char>, std::char_traits<char> >, boost::interprocess::managed_shared_memory::segment_manager> StringAllocator; typedef boost::interprocess::basic_string<char, std::char_traits<char>, StringAllocator> ShareableString; typedef boost::interprocess::allocator<boost::interprocess::deque<pwfmo_info_t_>, boost::interprocess::managed_shared_memory::segment_manager> DequeAllocator; typedef boost::interprocess::deque<pwfmo_info_t_, DequeAllocator> SharedDeque; boost::interprocess::interprocess_mutex Mutex; boost::interprocess::interprocess_condition Condition; ShareableString mName; bool State; ShareableDeque mRegisteredWaits; } Event.cpp #include <boost/date_time/posix_time/ptime.hpp> #include <boost/interprocess/sync/scoped_lock.hpp> int Event::WaitForEvent(int64_t milliseconds) { Mutex.lock(); if(!State) { boost::posix_time::ptime time; if (milliseconds == -1) { time = boost::date_time::microsec_clock<boost::posix_time::ptime>::local_time(); time += boost::posix_time::millisec (milliseconds); } do { boost::interprocess::scoped_lock<boost::interprocess::interprocess_mutex> lock (Mutex); if(milliseconds != -1) { result = Condition.timed_wait (lock, &time); } else { Condition.wait (lock); } } while(result == 0 && !State); if (result == 0) { State = false; } } Mutex.unlock (); return result; } When I try to compile the above code I get the following for the timed_wait(): /usr/include/boost/interprocess/sync/interprocess_condition:119:41 required from 'bool boost::interprocess::interprocess_condition::timed_wait (L&, const boost::posix_time::ptime&) [with L=boost::interprocess::interprocess_mutex]' /usr/include/boost/interprocess/sync/detail/locks.hpp:27:60 error no type named 'mutex_type' in 'class::boost::interprocess_mutex' I believe that I am declaring and using everything correctly, but obviously something isn't correct. I've been tearing what's left of my hair out trying to figure this out for the past couple of days and I haven't got anywhere. I assume there's some Boost guru out there that could solve/explain to me what's going on that I'm not getting. Any help would be appreciated. A: I added a scoped_lock inside the do...while() replacing the Mutex in the timed_wait() and wait() calls. This solved my compiler issues.
Catherine Zeta-Jones is back and better than ever after her recent bipolar II disorder diagnosis, says her husband Michael Douglas. "She's great! She's down in Miami doing 'Rock of Ages,' the musical," the 66-year-old actor told Us Weekly at the Urban Zen Stephan Weiss Awards in New York Thursday. "So she's doing great. She's doing a great job." Once Zeta-Jones, 41, wraps production on the star-studded film (which features Julianne Hough, Tom Cruise, Russell Brand, Alec Baldwin, Malin Akerman and Mary J. Blige), the two plan to "do the same thing we always do -- we go to Spain!" During a May interview with Oprah Winfrey, the "Wall Street" actor said his battle with stage four throat cancer was "very hard" on his wife. Adding to Zeta-Jones' worries, "My son is in federal prison, my ex-wife suing me ... it's kind of hard for the wife to say that she's depressed."
Improving communication with oncology patients: taping the consultation. Patients are often dissatisfied with the information provided for them by doctors. A simple cheap method of improving communication by tape recording the initial consultation with oncology outpatients is described. Analysis of 100 taped consultations by a subsequent questionnaire revealed that patients and their relatives claimed enormous benefit from the opportunity to hear the consultation again.
#include testing_aot_common_corlib_test.dll.exclude.sources Mono/NativePlatformTest.cs Mono/MonoNativePlatform.cs Mono/MonoNativePlatformType.cs Microsoft.Win32/RegistryKeyTest.cs System.Diagnostics.Contracts/ContractAssertTest.cs System.Diagnostics.Contracts/ContractAssumeTest.cs System.Diagnostics.Contracts/ContractCollectionMethodsTest.cs System.Diagnostics.Contracts/ContractHelperTest.cs System.Diagnostics.Contracts/ContractMarkerMethodsTest.cs System.Diagnostics.Contracts/ContractMustUseRewriterTest.cs System.Diagnostics.Contracts/Helpers/RunAgainstReferenceAttribute.cs System.Diagnostics.Contracts/Helpers/TestContractBase.cs System.Reflection.Emit/AssemblyBuilderAccessTest.cs System.Reflection.Emit/AssemblyBuilderTest.cs System.Reflection.Emit/ConstructorBuilderTest.cs System.Reflection.Emit/ConstructorOnTypeBuilderInstTest.cs System.Reflection.Emit/CustomAttributeBuilderTest.cs System.Reflection.Emit/DerivedTypesTest.cs System.Reflection.Emit/DynamicILInfoTest.cs System.Reflection.Emit/DynamicMethodTest.cs System.Reflection.Emit/EnumBuilderTest.cs System.Reflection.Emit/EventBuilderTest.cs System.Reflection.Emit/FieldBuilderTest.cs System.Reflection.Emit/GenericTypeParameterBuilderTest.cs System.Reflection.Emit/ILGeneratorTest.cs System.Reflection.Emit/MethodBuilderTest.cs System.Reflection.Emit/MethodBuilderTestIL.cs System.Reflection.Emit/MethodOnTypeBuilderInstTest.cs System.Reflection.Emit/MethodRentalCas.cs System.Reflection.Emit/MethodRentalTest.cs System.Reflection.Emit/ModuleBuilderTest.cs System.Reflection.Emit/ParameterBuilderTest.cs System.Reflection.Emit/PropertyBuilderTest.cs System.Reflection.Emit/SignatureHelperTest.cs System.Reflection.Emit/TypeBuilderTest.cs System.Reflection.Emit/SaveTest.cs System.Runtime.Remoting/ContextTest.cs System.Runtime.Remoting/RemotingConfigurationTest.cs System.Runtime.Remoting/SoapServicesTest.cs System.Runtime.Remoting/SynchronizationAttributeTest.cs System.Runtime.Remoting/RemotingServicesTest.cs System.Runtime.Remoting.Channels/ChannelServicesTest.cs System.Runtime.Remoting.Contexts/SynchronizationAttributeTest.cs System.Runtime.Remoting.Messaging/CallContextTest.cs System.Runtime.Remoting.Metadata.W3cXsd2001/SoapHexBinaryTest.cs System.Runtime.Remoting.Proxies/RealProxyTest.cs System.Security.AccessControl/AuthorizationRuleTest.cs System.Security.AccessControl/CommonAceTest.cs System.Security.AccessControl/CommonAclTest.cs System.Security.AccessControl/CommonObjectSecurityTest.cs System.Security.AccessControl/CommonSecurityDescriptorTest.cs System.Security.AccessControl/CryptoKeyAccessRuleTest.cs System.Security.AccessControl/DirectoryObjectSecurityTest.cs System.Security.AccessControl/DirectorySecurityTest.cs System.Security.AccessControl/DiscretionaryAclTest.cs System.Security.AccessControl/EventWaitHandleSecurityTest.cs System.Security.AccessControl/FileSecurityTest.cs System.Security.AccessControl/MutexAccessRuleTest.cs System.Security.AccessControl/MutexSecurityTest.cs System.Security.AccessControl/ObjectAceTest.cs System.Security.AccessControl/ObjectSecurity_TTest.cs System.Security.AccessControl/ObjectSecurityTest.cs System.Security.AccessControl/RawAclTest.cs System.Security.AccessControl/RawSecurityDescriptorTest.cs System.Security.AccessControl/RegistrySecurityTest.cs System.Security.AccessControl/SystemAclTest.cs System.Security.Permissions/CodeAccessSecurityAttributeTest.cs System.Security.Permissions/EnvironmentPermissionAttributeTest.cs System.Security.Permissions/EnvironmentPermissionTest.cs System.Security.Permissions/FileDialogPermissionAttributeTest.cs System.Security.Permissions/FileDialogPermissionTest.cs System.Security.Permissions/FileIOPermissionAttributeTest.cs System.Security.Permissions/FileIOPermissionTest.cs System.Security.Permissions/GacIdentityPermissionAttributeTest.cs System.Security.Permissions/GacIdentityPermissionTest.cs System.Security.Permissions/HostProtectionAttributeTest.cs System.Security.Permissions/IBuiltInPermissionTest.cs System.Security.Permissions/IsolatedStorageFilePermissionAttributeTest.cs System.Security.Permissions/IsolatedStorageFilePermissionTest.cs System.Security.Permissions/IsolatedStoragePermissionAttributeTest.cs System.Security.Permissions/KeyContainerPermissionAttributeTest.cs System.Security.Permissions/PermissionSetAttributeTest.cs System.Security.Permissions/PrincipalPermissionAttributeTest.cs System.Security.Permissions/PrincipalPermissionTest.cs System.Security.Permissions/PublisherIdentityPermissionAttributeTest.cs System.Security.Permissions/PublisherIdentityPermissionTest.cs System.Security.Permissions/ReflectionPermissionAttributeTest.cs System.Security.Permissions/ReflectionPermissionTest.cs System.Security.Permissions/RegistryPermissionAttributeTest.cs System.Security.Permissions/RegistryPermissionTest.cs System.Security.Permissions/SecurityAttributeTest.cs System.Security.Permissions/SecurityPermissionAttributeTest.cs System.Security.Permissions/SecurityPermissionTest.cs System.Security.Permissions/SiteIdentityPermissionAttributeTest.cs System.Security.Permissions/SiteIdentityPermissionTest.cs System.Security.Permissions/StrongNameIdentityPermissionAttributeTest.cs System.Security.Permissions/StrongNameIdentityPermissionTest.cs System.Security.Permissions/StrongNamePublicKeyBlobTest.cs System.Security.Permissions/UIPermissionAttributeTest.cs System.Security.Permissions/UIPermissionTest.cs System.Security.Permissions/UrlIdentityPermissionAttributeTest.cs System.Security.Permissions/UrlIdentityPermissionTest.cs System.Security.Permissions/ZoneIdentityPermissionAttributeTest.cs System.Security.Permissions/ZoneIdentityPermissionTest.cs System.Security.Policy/AllMembershipConditionTest.cs System.Security.Policy/ApplicationDirectoryMembershipConditionTest.cs System.Security.Policy/ApplicationDirectoryTest.cs System.Security.Policy/ApplicationMembershipConditionTest.cs System.Security.Policy/ApplicationSecurityManagerCas.cs System.Security.Policy/ApplicationSecurityManagerTest.cs System.Security.Policy/ApplicationTrustTest.cs System.Security.Policy/CodeGroupTest.cs System.Security.Policy/DomainApplicationMembershipConditionTest.cs System.Security.Policy/EvidenceTest.cs System.Security.Policy/FileCodeGroupTest.cs System.Security.Policy/FirstMatchCodeGroupTest.cs System.Security.Policy/GacMembershipConditionTest.cs System.Security.Policy/GacTest.cs System.Security.Policy/HashMembershipConditionTest.cs System.Security.Policy/HashTest.cs System.Security.Policy/IBuiltInEvidenceTest.cs System.Security.Policy/NetCodeGroupTest.cs System.Security.Policy/PermissionRequestEvidenceTest.cs System.Security.Policy/PolicyLevelTest.cs System.Security.Policy/PolicyStatementTest.cs System.Security.Policy/SiteMembershipConditionTest.cs System.Security.Policy/SiteTest.cs System.Security.Policy/StrongNameMembershipConditionTest.cs System.Security.Policy/StrongNameTest.cs System.Security.Policy/UnionCodeGroupTest.cs System.Security.Policy/UrlMembershipConditionTest.cs System.Security.Policy/UrlTest.cs System.Security.Policy/ZoneMembershipConditionTest.cs System.Security.Policy/ZoneTest.cs
Q: ubuntu-touch on convertible (x86, 12.04) I would like to test drive ubuntu-touch on a 12.04 based convertible notebook. This is a normal notebook without android and a intel amd64 capable cpu (not arm cpu). (See also the Shuttleworth presentation, e.g. http://www.heise.de/open/meldung/Ubuntu-kommt-aufs-Tablet-1806342.html) So my questions are: Have someone tried this before? What special packages I have to install? Is there a ppa containing this packages for precise? alternative: There can I find the package sources to build them for precise in my own ppa? Any information is welcome. A: Read here https://wiki.ubuntu.com/Touch/Porting: "As Ubuntu Touch is running in a separated container on top of an Android kernel and services, the communication between them happens via Binder, Sockets and libhybris." Ubuntu touch has a kind of Android based layer where Ubuntu Touch is working on top of it. At least for the first release this will probably the first choice so that many android models can be ported to Ubuntu Touch with reasonable effort. But this means also that any other device which is not based on android will be very (extremely) difficult to be ported. Sorry.
-- malloc5.test -- -- execsql { -- COMMIT; -- } COMMIT;
It Just Got Easier to Sue Failed Kickstarter Campaigns for a Refund Kickstarter has decided to update its famously laissez-faire attitude when it comes to protecting donors who have pledged more than $1 billion through the company over the years. The new terms state that a successfully funded campaign that fails to produce "rewards," i.e. the product, may have to "return remaining funds." If not, they could be "subject to legal action by backers." Backers could previously sue campaign creators, but rarely did so. The new rules, which go into effect on October 19th, make the potential for a lawsuit more explicit (check out the differences here). The amended TOS says that by backing a project, donors are entering into a "contract" with creators. Kickstarter then lists all the things a creator has to do if a product does not materialize, including "offer to return any remaining funds." If creators fails to bring the contract to the "best possible conclusion," the "legal action" part kicks in. Below is a screenshot of the relevant change. As you can see, Kickstarter is very careful to note that "Kickstarter is not a part of this contract." Much like Airbnb hosts paying taxes or UberX lowering prices, the potential cost trickles down the sharing economy. If you missed the part about Kickstarter not being responsible, the company also clarified its limited liability clause: Kickstarter insists that changes to its terms of service are entirely unrelated to the new FTC rule around refunds from online retailers, which also happened to be announced last week, telling TechCrunch: "Our Terms update has been in the works for months and was driven by a longterm effort to make everything about them straightforward and clear." The inclement legal climate would make any crowdfunding company wary. The FTC has been discussing updating that refund rule for seven years, reports The Daily Dot: The new name, according to the Federal Register, is the Mail, Internet, or Telephone Order Merchandise Rule. It "prohibits sellers from soliciting mail, Internet, or telephone order sales unless they have a reasonable basis to expect that they can ship the ordered merchandise within the time stated on the solicitation or, if no time is stated, within 30 days." The FTC's new amendments to the decades-old regulation "permit refunds and refund notices by any means at least as fast and reliable as first class mail" and "require sellers to process any third-party credit card refunds [within] seven working days." Then there's the lawsuit filed by Washington State Attorney General Bob Ferguson against a company called Altius Management for failing to deliver on promises to Kickstarter donors. Sorry, benevolent backers, there is still no legal recourse for accidentally making rich people richer. It was pretty drab and I love love love that show (if you subtract every scene with Duncan and blip out every time his name comes up and generally excommunicate him from the series). Why was Logan so skinny?? They should have fed him potato salad. The new terms state that a successfully funded campaign that fails to produce "rewards," i.e. the product, may have to "return remaining funds." And for the nominal fee of just $499.99, Kickstarter offers campaign owners a class in creative ways to say, "Aw, I'm sorry. I wish I could help you out, but there are no "remaining funds'. Such a damn shame. Hey, btw, do you like my new gold Apple Watch?"
<?php /* * This file is part of PHPExifTool. * * (c) 2012 Romain Neutron <[email protected]> * * For the full copyright and license information, please view the LICENSE * file that was distributed with this source code. */ namespace PHPExiftool\Driver\Tag\DICOM; use JMS\Serializer\Annotation\ExclusionPolicy; use PHPExiftool\Driver\AbstractTag; /** * @ExclusionPolicy("all") */ class IsocenterToRangeShifterDistance extends AbstractTag { protected $Id = '300A,0364'; protected $Name = 'IsocenterToRangeShifterDistance'; protected $FullName = 'DICOM::Main'; protected $GroupName = 'DICOM'; protected $g0 = 'DICOM'; protected $g1 = 'DICOM'; protected $g2 = 'Image'; protected $Type = '?'; protected $Writable = false; protected $Description = 'Isocenter To Range Shifter Distance'; }
This copy is for your personal non-commercial use only. To order presentation-ready copies of Toronto Star content for distribution to colleagues, clients or customers, or inquire about permissions/licensing, please go to: www.TorontoStarReprints.com The Big Deal: Will a civilian review of G20 allow us to move forward? Amid a fraught climate, a civilian review of police actions during the G20 summit in Toronto is scheduled to begin this week. By Sarah BarmakSpecial to The Star Fri., May 27, 2011 The world has moved on, but Toronto is still mired in 2010. This year’s G8 and G20 summits in France are the stuff of current international news. But here, no one is much interested in commenting on how Stephen Harper has been performing alongside world leaders, or his plans for the G20 in Cannes in November. Somehow, we just can’t seem to pay attention. It might have something to do with the way we’ve been constantly reliving the gong show that was the G20 in this city last year. Only last week, fresh video surfaced showing Dorian Barton appearing to be kicked, hit with batons and dragged by police with riot gear in the streets while the summit went on. The Special Investigations Unit decided for the third time to reopen its probe into what happened, after Toronto Police announced they would give more information about their ID of a cop appearing to be attacking Barton in a photo. We’ve been reliving the fiasco because, as so many have lamented, only one of the many investigations into what exactly happened in this city during the G20 weekend has been tabled. Article Continued Below With answers from investigators elusive, moving forward has been impossible. It is in this fraught climate that a civilian review of police actions during the G20 summit in Toronto is scheduled to begin this week, with a first hearing set for 5:30 p.m. on Wednesday at Metro Hall. Two later hearings will be held June 6 at the Etobicoke Civic Centre and June 13 at the Scarborough Civic Centre. Launched on Sept. 23 of last year by the Toronto Police Services Board, the Independent Civilian Review will be conducted by retired judge John W. Morden. It’s billed as a chance for the public to give input on the role civilian oversight should play in the policing of future events, as well as whether the police strategy last year was “effective.” Now there’s a novel question. Can’t imagine the public’s response to that one. “Civilian oversight” of police can mean something as narrow as public complaints about specific actions by the cops. But it also refers to the entire system by which the public outside the justice system holds the police accountable for their actions. In theory. Some have questioned whether the public hearing will really matter in practice, however, especially with so many other reviews and investigations having failed to get results. A glance at the Facebook page titled “Canadians Demanding a Public Inquiry into Toronto G20” shows members scoffing at the hearing. “BUT do not expect any REAL answers or justice out of this,” wrote one angry user. Indeed, the specific question the public has been invited to speak on — “What role should civilian oversight play with respect to the policing of major events?” — sounds calculated to be both fatuously vague (what the heck are “major events”?) and hypothetical. The website says speakers will be interrupted if they stray from the question. But it’s hard to imagine anyone who was kettled at Queen St. and Spadina Ave. last year actually keeping their submissions confined to potential “major events” in the future — or sitting down when told by some functionary. There are signs there is healthy public interest in the hearings. The deadline for members of the public who wish to participate to submit official forms has been extended until Tuesday. Cynical as we have become, it’s clear Toronto is still willing to try anything that will allow us to move forward. Let’s hope it’s not a wasted effort. Delivered dailyThe Morning Headlines Newsletter The Toronto Star and thestar.com, each property of Toronto Star Newspapers Limited, One Yonge Street, 4th Floor, Toronto, ON, M5E 1E6. You can unsubscribe at any time. Please contact us or see our privacy policy for more information. More from the Toronto Star & Partners LOADING Copyright owned or licensed by Toronto Star Newspapers Limited. All rights reserved. Republication or distribution of this content is expressly prohibited without the prior written consent of Toronto Star Newspapers Limited and/or its licensors. To order copies of Toronto Star articles, please go to: www.TorontoStarReprints.com
The present invention relates to the field of data processing. More particularly, this invention relates to the configuration of a processor core configured to carry out data processing operations. Heterogeneous multicore systems—comprised of multiple cores with varying capabilities, performance, and energy characteristics—have emerged as a promising approach to increasing energy efficiency and alleviating serial bottlenecks. The big.LITTLE technology provided by ARM Limited, Cambridge, UK is one example. This technology combines a set of Cortex-A15 (“big”) cores with Cortex-A7 (“LITTLE”) cores to create a heterogeneous processor. The Cortex-A15 is a 3-way out-of-order device with deep pipelines (15-25 stages). Conversely, the Cortex-A7 is a narrow in-order processor with a relatively short pipeline (8-10 stages). The Cortex-A15 has 2-3× higher performance, but the Cortex-A7 is 3-4× more energy efficient. Such systems reduce energy consumption by identifying phase changes in an application and migrating execution to the most efficient core that meets its current performance requirements. Known designs select the best core by briefly sampling performance on each. However, every time the application migrates between cores, its current state must be explicitly transferred or rebuilt on the new core. This state transfer incurs large overheads that limits migration between cores to a granularity of tens to hundreds of millions of instructions. To mitigate these effects, the decision to migrate applications is done at the granularity of operating system time slices. R. Kumar, K. I. Farkas, N. P. Jouppi, P. Ranganathan, and D. M. Tullsen, “Single-ISA Heterogeneous Multi-Core Architectures: The Potential for Processor Power Reduction,” in Proc. of the 36th Annual International Symposium on Microarchitecture, December 2003, pp. 81-92, considers migrating thread context between out-of-order and in-order cores for the purposes of reducing power. At coarse granularities of 100M instructions, one or more of the inactive cores are sampled by switching the thread to each core in turn. The switches comprise flushing dirty L1 data to a shared L2, which is slow and energy consuming. Rather than relying on sampling the performance on both cores, K. Van Craeynest, A. Jaleel, L. Eeckhout, P. Narvaez, and J. Emer, “Scheduling heterogeneous multi-cores through performance impact estimation (pie),” in Proceedings of the 39th International Symposium on Computer Architecture, ser. ISCA '12, 2012, pp. 213-224 proposes a coarse-grained mechanism that relies on measures of CPI, MLP, and ILP to predict the performance on the inactive core. On the other hand, K. K. Rangan, G.-Y. Wei, and D. Brooks, “Thread motion: fine-grained power management for multi-core systems,” in Proc. of the 36th Annual International Symposium on Computer Architecture, 2009, pp. 302-313 examines a CMP with clusters of in-order cores sharing L1 caches. While the cores are identical architecturally, varied voltage and frequency settings create performance and power heterogeneity. A simple performance model is made possible by having exclusively in-order cores, and thread migration is triggered every 1000 cycles by a history-based (last value) predictor. Another class of work targets the acceleration of bottlenecks to thread parallelism. Segments of code constituting bottlenecks are annotated by the compiler and scheduled at runtime to run on a big core. M. A. Suleman, O. Mutlu, M. K. Qureshi, and Y. N. Patt, “Accelerating critical section execution with asymmetric multi-core architectures,” in 17th International Conference on Architectural Support for Programming Languages and Operating Systems, 2009, pp. 253-264 describes a detailed architecture and target critical sections, and J. A. Joao, M. Suleman, O. Mutlu, and Y. N. Patt, “Bottleneck identification and scheduling in multithreaded applications,” in 20th International Conference on Architectural Support for Programming Languages and Operating Systems, 2012, pp. 223-234 generalizes this work to identify the most critical bottlenecks at runtime. G. Patsilaras, N. K. Choudhary, and J. Tuck, “Efficiently exploiting memory level parallelism on asymmetric coupled cores in the dark silicon era,” ACM Trans. Archit. Code Optim., vol. 8, no. 4, pp. 28:1-28:21, January 2012 proposes building separate cores, one that targets MLP and the other that targets ILP. They then use L2 cache miss rate to determine when an application has entered a memory intensive phase and map it to the MLP core. When the cache misses decrease, the system migrates the application back to the ILP core. Other work studies the benefits of heterogeneity in real systems. M. Annavaram, E. Grochowski, and J. Shen, “Mitigating Amdahl's law through EPI throttling,” in Proceedings of the 32nd Annual International Symposium on Computer Architecture, 2005, pp. 298-309 shows the performance benefits of heterogeneous multi-cores for multithreaded applications on a prototype with different frequency settings per core. Y. Kwon, C. Kim, S. Maeng, and J. Huh, “Virtualizing performance asymmetric multi-core systems,” in Proc. of the 38th Annual International Symposium on Computer Architecture, 2011, pp. 45-56 motivates asymmetry-aware hypervisor thread schedulers, studying cores with various voltage and frequency settings. D. Koufaty, D. Reddy, and S. Hahn, “Bias scheduling in heterogeneous multi-core architectures,” in Proc. of the 5th European Conference on Computer Systems, 2010, pp. 125-138 discovers an application's big or little core bias by monitoring stall sources, to give preference to OS-level thread migrations which migrate a thread to a core it prefers. A heterogeneous multi-core prototype is produced by throttling the instruction retirement rate of some cores down to one instruction per cycle. Other designs propose allowing a thread to adapt (borrow, lend, or combine) hardware resources, and still other designs allow dynamic voltage/frequency scaling (DVFS). Alternatively, asymmetry can be introduced by dynamically adapting a core's resources to its workload. Prior work has suggested adapting out-of-order structures such as the issue queue (see R. Bahar and S. Manne, “Power and energy reduction via pipeline balancing,” Proc. of the 28th Annual International Symposium on Computer Architecture, vol. 29, no. 2, pp. 218-229, 2001), as well as other structures such as ROBs, LSQs, and caches (see: D. Ponomarev, G. Kucuk, and K. Ghose, “Reducing power requirements of instruction scheduling through dynamic allocation of multiple datapath resources,” in Proc. of the 34th Annual International Symposium on Microarchitecture, December 2001, pp. 90-101; R. Balasubramonian, D. Albonesi, A. Buyuktosunoglu, and S. Dwarkadas, “Memory hierarchy reconfiguration for energy and performance in general-purpose processor architectures,” in Proceedings of the 33rd annual ACM/IEEE international symposium on Microarchitecture, 2000, pp. 245-257; and D. Albonesi, R. Balasubramonian, S. Dropsbo, S. Dwarkadas, E. Friedman, M. Huang, V. Kursun, G. Magklis, M. Scott, G. Semeraro, P. Bose, A. Buyuktosunoglu, P. Cook, and S. Schuster, “Dynamically tuning processor resources with adaptive processing,” IEEE Computer, vol. 36, no. 12, pp. 49-58, December 2003). R. Kumar, N. Jouppi, and D. Tullsen, “Conjoined-core chip multiprocessing,” in Proc. of the 37th Annual International Symposium on Microarchitecture, 2004, pp. 195-206 explored how a pair of adjacent cores can share area expensive structures, while keeping the floorplan in mind H. Homayoun, V. Kontorinis, A. Shayan, T.-W. Lin, and D. M. Tullsen, “Dynamically heterogeneous cores through 3d resource pooling,” in Proc. of the 18th International Symposium on High-Performance Computer Architecture, 2012, pp. 1-12 examined how micro-architectural structures can be shared across 3D stacked cores. These techniques are limited by the structures they adapt and cannot for instance switch from an out-of-order core to an in-order core during periods of low ILP. E. Ipek, M. Kirman, N. Kirman, and J. Martinez, “Core fusion: Accommodating software diversity in chip multiprocessors,” in Proc. of the 34th Annual International Symposium on Computer Architecture, 2007, pp. 186-197 and C. Kim, S. Sethumadhavan, M. S. Govindan, N. Ranganathan, D. Gulati, D. Burger, and S. W. Keckler, “Composable lightweight processors,” in Proceedings of the 40th Annual IEEE/ACM International Symposium on Microarchitecture, 2007, pp. 381-394 describe techniques to compose or fuse several cores into a larger core. While these techniques provide a fair degree of flexibility, a core constructed in this way is generally expected to have a datapath that is less energy efficient than if it were originally designed as an indivisible core of the same size. DVFS approaches reduce the voltage and frequency of the core to improve the core's energy efficiency at the expense of performance. However, when targeted at memory-bound phases, this approach can be effective at reducing energy with minimal impact on performance. Similar to traditional heterogeneous multicore systems, the overall effectiveness of DVFS suffers from coarse-grained scheduling intervals in the millisecond range. In addition, providing independent DVFS settings for more than two cores is costly in terms of both area and energy. Despite these limitations, DVFS is still widely used in production processors today, and has for example been incorporated into the above-mentioned ARM big.LITTLE heterogeneous multicore system. Two competing techniques to enable fine-grained DVFS, fast on-chip regulators (see W. Kim, M. S. Gupta, G.-Y. Wei, and D. Brooks, “System level analysis of fast, per-core DVFS using on-chip switching regulators,” in Proc. of the 14th International Symposium on High-Performance Computer Architecture, 2008, pp. 123-134 and W. Kim, D. Brooks, and G.-Y. Wei, “A fully-integrated 3-level DCDC converter for nanosecond-scale DVFS,” IEEE Journal of Solid-State Circuits, vol. 47, no. 1, pp. 206-219, January 2012) and dual voltage rails (see T. N. Miller, X. Pan, R. Thomas, N. Sedaghati, and R. Teodorescu, “Booster: Reactive core acceleration for mitigating the effects of process variation and application imbalance in low-voltage chips,” in Proc. of the 18th International Symposium on High-Performance Computer Architecture, vol. 0, 2012, pp. 1-12 and R. Dreslinski, “Near threshold computing: From single core to manycore energy efficient architectures,” Ph.D. dissertation, University of Michigan, 2011), have recently been proposed that promise to deliver improved transition latencies. Despite these varied advances in the technology, the applicant considers that there remains the opportunity to improve on the prior art.
Smart Home Automation Excellent Quality- Great Staff - Happy Clients Control 4 remote used to control alarms, aircons, blinds and gates Smart Home Automation Smart Home Automation is the link between you and your home's equipment. The system allows you to control audio & video equipment, lights, alarm systems, aircons, blinds, motorized curtains and brackets and any relay switched devices like underfloor heating and high powered electric circuits. The system can be connected to new or existing buildings - thanks to its unique wireless technology called ZigBee. The wireless technology in Control 4 is a mesh network which allows all Control 4 devices to monitor and "talk" to each other, making it a very fast technology. This allows for very fast operation, so if you press the button, the lights come on instantly. Controlling your system can be done from a Smart phone, iPhone, iPad, Android device, a in wall touch screen or remote control. We at Jeff's Hi-Fi Shop do all the programming of the system in house, which allow customers to have a unique programmed house. Things like light scenes, audio playlists, away modes, emergency feedback and remote viewing are all things we configure for you.
Header Right How Can I Cure Chronic Achy Legs? Question: I’m an avid 47-year-old cyclist who rides 90-120 miles per week and wants to improve. My performance has stagnated. My legs ache and feel weak. Is this just age, or is it overtraining or poor nutrition? — Craig K. Coach Fred Matheny Replies: It sounds like you’ve overdone your training, Craig, either in terms of intensity or insufficient time for recovery. Another factor might be that you’re not eating enough carbohydrate to replenish glycogen (muscle fuel) between rides. Any of these factors can make your legs beg for life support. To snap back, try an easy week. Cut your mileage and intensity by about a third. In addition, eat more carbohydrate and total calories. A post-ride recovery drink such as Endurox might help, too. Your legs should feel better and your motivation should return as the rest week goes along. If not, try a second easy week. If that doesn’t do it, you might want to consider a medical checkup to rule out anything else that could be causing your problems.
Radioimmunodetection of cancer using antibodies to alpha-fetoprotein and carcinoembryonic antigen. This study reports the use of radiolabeled antibody to AFP and CEA for the detection and localization of AFP- or CEA-producing tumors. Thirty-one patients received 131I-labeled anti-AFP or anti-CEA antibodies. Photoscans were taken at 24 and 48 hours after injection of radioantibodies. In three of six patients with CEA-producing tumors, radioimmunodetection with anti-CEA antibody showed positive scans. In AFP-producing tumors, 7 of 15 patients had positive findings on immunoscintigraphy using polyclonal anti-AFP antibody, and two of nine patients had positive findings when monoclonal antibodies were used. Analysis of radioantibody in the blood after injection showed both complex and free antibody with immunoreactivity in the circulation, and smaller complexes were seen to form after administration of monoclonal antibodies.
One of Winnipeg's oldest parks — dating back to a time when public spaces were known as ornamental squares or "breathing centres" — is getting renewed recognition. The Winnipeg Architecture Foundation has launched a walking tour booklet that showcases the history of Central Park, a 125-year-old green space that was once a retreat from the bustle of the city life but is now in the thick of it. It highlights architectural features of the park, like the 1914 Waddell Fountain and its quirky background story, and the changing neighbourhood surrounding it. The booklet contains old photos of the neighbourhood and park just north of the city's downtown — with some before-and-after images of the architecture that remains. "There's just this wealth of information, and quite a wonderful collection of different buildings and landscapes that we wanted to highlight," said Marieke Gruwel, an architectural researcher at the Winnipeg Architecture Foundation. "It's also an important part of the city that's worth highlighting." The Benard House at the corner of Edmonton Street and Cumberland Avenue, seen in 1903, left, and 2019, right. (City of Winnipeg/Winnipeg Architecture Foundation) The idea for Central Park was planted in 1893 when the newly formed Public Parks Board bought property to create Winnipeg's first four parks. In its annual report from that year, the board stated it would establish "ornamental squares, or breathing places, throughout the city." To develop several smaller public green spaces, rather than developing one large suburban city park, was an unusual plan for a Canadian city back then, according to Catherine Macdonald's book A City at Leisure: An Illustrated History of Parks and Recreation Services in Winnipeg. It wasn't until 1909 that Winnipeg opened its first big suburban park — City Park, later renamed Assiniboine Park — on what was then its far western fringe. An early photo shows Edmonton Street with Central Park on the left, when it was much smaller. (Peel’s Prairie Provinces/University of Alberta) Those first four parks, or breathing spaces, were: Central Park, off Ellice Avenue. Fort Rouge (initially named Assiniboine Park but changed when the bigger park took that name) alongside River Avenue. St. John's off Main Street. Victoria Park, at the end of James Avenue, near a bend in the Red River. It became a significant place during the 1919 Winnipeg General Strike as the site of many pivotal striker gatherings. Unlike the other three parks, which still exist, this one was destroyed by the city in 1922 to build a heating plant. Today, a condo building at the corner of Waterfront Drive and Pacific Avenue marks the spot. The land for Central Park was purchased from the Hudson's Bay Company for $20,000 and developed in short time, opening in 1894 to serve the booming city's middle class. Groups of men play checkers in Central Park in the summer of 1962. (University of Winnipeg Archives/Hugh Allan collection) It quickly gained popularity as a spot to get away from city life, with a tennis court, bandshell and large gardens in place by the early 1900s, according to the WAF booklet. The Waddell Fountain was installed in 1914 to commemorate Emily Margaret Waddell, who loved the park and often visited it. She died in 1909 and her will contained a strange provision — should her husband, Thomas, ever remarry, he would be required to donate $10,000 to the city for construction of a fountain. In 1911, when Thomas was engaged to be married, he was in debt due to some real estate investments that went belly up, according to local historian George Siamandas. An undated photograph of Waddell Fountain. (University of Manitoba Archives/Henry Kalen fonds) It took two years, but Thomas acquired the funds and met his obligation. The fountain was designed by local architect John Manuel, who later relocated to Alberta to direct construction of Canadian Pacific Railway hotels at Banff and Lake Louise. After many years of neglect, the fountain was in desperate need of rehabilitation and in 2010, the city undertook a major restoration that included repairs, cleaning, and carving new pieces to replace missing and damaged ones. Changing times The Central Park neighbourhood has since gone through many changes, as much of the middle class population moved to suburban areas and the park's use fell into decline. The number of people living in the area decreased through the 1970s on, and the park's popularity fell. Apartments replaced many of the houses in the area and crime rates spiked. The Central Park area has since transitioned into a community for many new Canadians with diverse cultural backgrounds, and serves as a starting point for many immigrant and refugee families beginning new lives in the city. The Central Park area serves as a starting point for many immigrant and refugee families. (Mary Lou Driedger/Destination Winnipeg) Where it used to be a place for people to get away from city life for a country feel, it is now located in one of the most densely populated parts of the city, with 15,000 people per square kilometre, according to the City of Winnipeg. In fact, according to a 2008 CBC report, 70 per cent of all refugees coming to Winnipeg at that point lived downtown, largely settling in and around the Central Park area. In 1985, the city hired a landscape architecture firm to design an extension to Central Park. It used to end at Qu'Appelle Avenue but a section of that street was closed off, allowing the park to be expanded to Ellice Avenue. The plan was to link Central Park to the legislative grounds but the development of north Portage, and the construction of Portage Place mall, snuffed that out, according to the WAF booklet. An image of the plan for the 2008 revitalization of Central Park by the landscape architecture firm Scatliff+Miller+Murray. (Scatliff+Miller+Murray) In 2008, the city launched a major revitalization of the park, completed in 2012 for $5.6 million. It added a wading pool and spray park, artificial turf, four-season slides, and an interactive sand and water play area with a play structure. Through it all, the park and much of its historical beauty remains. However, for many, it hasn't been able to shake the reputation it gained in the '70s as a dangerous area. "The reputation stems from when it was rundown and not safe, but it's actually really popular and widely used," said Gruwel. "It's an important space for people to meet, play soccer; there are so many different uses for it." Actors with Shakespeare in the Ruins perform a production of A Midsummer Night’s Dream beside the Waddell Fountain in Central Park. (Mary Lou Driedger/Destination Winnipeg) The architecture foundation hopes its walking tour can shine light on an important and historical neighbourhood that is now one of the most diverse gems in the city. Central Park is now establishing a new sense of community and culture through live entertainment in summer and outdoor markets that sell handmade and imported African clothing, beadwork, handicrafts, weavings, art, and organic produce, according to a description from the city. Winnipeggers throw cupfuls of paint onto canvases in Central Park as part of a community event in 2015. (Jeff Stapleton/CBC) "I think every neighborhood always has its challenges and I think Central Park today is such a wonderful gathering space and it's such a fun place," said Gruwel. The WAF offers occasional tours of Central Park, and those who take them are often surprised, she said. "Everyone is often, 'Wow, I didn't know this this was here. This is so amazing … there's so many fun things to do in the area.' "So I really I think folks should go down and check it out for themselves."
North Korean nuclear scientists apparently ignored warnings from a group of Chinese colleaugues who briefed them back in September that the North’s Punggye-ri nuclear test site was slowly imploding following the country’s sixth nuclear test, which involved a 100-kiloton hydrogen bomb roughly seven times more powerful than the weapon dropped by the US on Hiroshima in 1945. As Japanese TV station Asahi TV reported Tuesday, more than 200 North Koreans were killed earlier this month when several tunnels in the underground complex collapsed, killing more a crew of laborers and a crew of rescue workers sent to save them. As we’ve reported previously, scientists in the US, China and South Korea have warned that further tests at the site could blow the top off the mountain, causing it to collapse. Meanwhile, it could send a plume of radioactive particles into the atmosphere that could deleteriously impact population centers in Northern China and across the region. Scientists detected a series of small earthquakes under Punggye-ri after the country’s Sept. 3 nuclear test. The seismic activity, combined with satellite images of landslides and depressions forming on the mountain’s surface, led a group of American scientists to declare that Punggye-ri was suffering from “tired mountain syndrome” – a condition previously observed at Soviet nuclear test sites. South Korea’s weather agency chief Nam Jae-Cheol told a meeting of the lawmakers Monday that any future nuclear test at the site could cause a collapse. One of the Korea Meteorological Administration researchers, Lee Won-Jin, presented an analysis of satellite images indicating landslides occurred near the facility following the September test. The small-scale quakes at the facility, built south of the Mantapsan mountain, suggest it may not be stable enough to conduct any further tests. However, the construction of new underground tunnels in the complex would suggest the North – unwilling or unable to build an entirely new facility in a different location – has instead opted to move its tests to another area of the mountain. “If North Korea were to attempt to continue testing under this mountain (such as in the area more to the eastern side), then we would expect to see new tunneling in the future near the North Portal, still under Mt. Mantap,” researchers Frank Pabian and Jack Liu wrote in a report published earlier this month. Of course, the condition of the test site would be irrelevant if the North decides to follow through with a threat to conduct “an unprecedented scale hydrogen bomb” test over the Pacific. North Korean officials have insisted in recent weeks that these threats are serious. Perhaps the Kim regime has been so preoccupied assessing the damage at Pyungge-ri, where five of the North’s six nuclear tests held since 2006 have taken place, that it has been forced to put any future tests on hold. Fearing a collapse, China has stepped up its radiation monitoring on the border. Meanwhile, a researcher studying the radioactive risk from the North Korean nuclear program at Peking University said China could no longer tolerate another land-based explosion. “China cannot sit and wait until the site implodes. Our instruments can detect nuclear fallout when it arrives, but it will be too late by then. There will be public panic and anger at the government for not taking action,” the researcher said. “Maybe the North Koreans themselves have realized that the site cannot take another blow. If they still want to do it, they have to do it somewhere else.”
Necropsy of adult cattle. This article presents a brief overview of some examination techniques commonly used during necropsy of adult cattle. A few common diseases and their typical lesions are described and appropriate laboratory techniques to confirm or help deny the roles of specific agents are mentioned.
A teacher who posted photographs on the internet of schools which collapsed in the Sichuan earthquake has been sent to a labour camp for a year, a rights group said yesterday. Liu Shaokun was ordered to serve a year of "re-education through labour", according to Human Rights in China. The system does not require a charge or criminal trial and is not subject to court appeals. He is believed to be the third person held after questioning why so many schools were destroyed in the earthquake. Scores of schools across the southwestern province collapsed following the 7.9 magnitude shock. In many cases, buildings around them remained intact, prompting questions about the quality of their construction. The authorities initially responded to public outrage by promising an inquiry into whether shoddy building work was linked to corruption. But they have subsequently silenced critics, ordering state media to avoid the subject and preventing parents from protesting. In recent weeks police have dragged grieving relatives away from demonstrations in some areas. Families have also been pressed to take compensation in exchange for signing contracts which include commitments not to protest or attempt to sue the authorities. "Instead of investigating and pursuing accountability for shoddy and dangerous school buildings, the authorities are resorting to re-education through labour to silence and lock up concerned citizens like teacher Liu Shaokun and others," said Sharon Hom, executive director of Human Rights in China. The group said that Liu, a teacher at Guanghan middle school in Deyang city, was detained on June 25 for "disseminating rumours and destroying social order." His wife, who has not been allowed to see him, was told last week that he had been sent to a labour camp. He had travelled through the quake zone taking pictures of the ruins of schools and circulating them on the internet, along with criticism. The public security bureau in Deyang told the Guardian it was trying to find out more about the matter and the Guanghan city propaganda department said it had not heard of the case. But an official with the general office of the Guanghan school where Liu worked told Reuters: "He was detained late last month by people from national security bureau for deliberately inciting families of victims to petition and disseminating anti-government rumours. They searched his home and found evidence." The family of Huang Qi, a longstanding rights activist from Sichuan, said this month that he had been formally arrested for "illegal possession of state secrets" after helping bereaved parents and posting articles about structural failings of schools on his website. China's human rights record and lack of political freedom are under increasing scrutiny with the Olympic games only days away. Yesterday a senior official from the International Olympic Committee admitted that colleagues had cut a deal to let Beijing block sensitive websites despite promises of unrestricted access. Yesterday journalists at the main press centre were unable to access sensitive sites, including that of Amnesty International, which this week released a highly critical report on human rights in China.
A Russian military officer displays a chemical lab during a briefing by Russian Foreign and Defense Ministries in Kubinka Patriot park outside Moscow, Russia, Friday, June 22, 2018. Russian officials said the lab was used by the rebels to produce mustard gas and contained equipment made in Western Europe. Russia said Friday that the U.S. and its allies have relied on fabricated evidence to accuse the Syrian government of launching chemical attacks against civilians. Russia’s foreign and defense ministries also charged that the international chemical weapons watchdog has failed to objectively investigate the alleged chemical attacks and is subject to political control. (AP Photo) A Russian military officer displays a chemical lab during a briefing by Russian Foreign and Defense Ministries in Kubinka Patriot park outside Moscow, Russia, Friday, June 22, 2018. Russian officials said the lab was used by the rebels to produce mustard gas and contained equipment made in Western Europe. Russia said Friday that the U.S. and its allies have relied on fabricated evidence to accuse the Syrian government of launching chemical attacks against civilians. Russia’s foreign and defense ministries also charged that the international chemical weapons watchdog has failed to objectively investigate the alleged chemical attacks and is subject to political control. (AP Photo) MOSCOW (AP) — Russia said Friday that the U.S. and its allies have relied on fabricated evidence to accuse the Syrian government of launching chemical attacks against civilians. Russia’s foreign and defense ministries also charged the international chemical weapons watchdog with failing to objectively investigate the alleged chemical attacks and with being subject to political control. ADVERTISEMENT Maj. Gen. Igor Kirillov, the chief of the Russian military’s radiation, chemical and biological protection unit, said investigators from the Organization for the Prohibition of Chemical Weapons had failed to visit the sites of alleged use of sarin and chlorine, and trusted evidence produced by activists, which he described as rigged. Syria has rejected the accusations of chemical attacks. “The U.S., Britain, France and their allies have misled international community ... relying on fabrications to accuse Syria of violating the chemical weapons ban with Russian assistance,” Kirillov said at a briefing. Kirillov alleged that the White Helmets first responders working in rebel-controlled areas had doctored samples and used explosive devices to make craters that looked like those left by bombs. In the images presented by activists, they worked at the site of the alleged use of sarin without protective gear, which would have been impossible if the nerve agent had indeed been used there, he added. Kirillov scoffed at the images of massive gas canisters activists said were dropped by government helicopters in the purported chemical attack on the town of Douma just outside Damascus on April 7. “Surprisingly, the 100-kilogram canisters left tableware and furniture undamaged, and even a bed on which the canister fell was intact, signaling that the canister was dragged into the room, as indicated by signs left on the floor,” he said. The alleged use of chemical weapons in Douma triggered a punitive missile strike by the U.S., Britain and France that Russia has condemned as a violation of international law. The OPCW’s fact-finding team is not mandated to apportion blame. A joint UN-OPCW team that was tasked with determining blame for such attacks no longer exists after Russia, a close ally of the Syrian government, last year vetoed a U.N. Security Council resolution to extend its mandate. Kirillov criticized the OPCW for turning a blind eye to the discovery of rebel stockpiles that contained over 40 metric tons of chlorine and other toxic chemicals. ADVERTISEMENT He noted that a rebel chemical lab found in Douma after the town was taken over by Syrian government forces contained components used in the production of mustard gas. A canister with chlorine — similar to those used in the purported attack in April — was also found at the same lab, he added. The Russian foreign ministry’s spokeswoman, Maria Zakharova, who spoke at the same briefing, said that the chemical lab featured components made in Western Europe. Kirillov charged that last week’s report by the OPCW’s fact-finding mission in Syria — concluding that sarin and chlorine were likely used in attacks near Latamneh, in the province of Hama, in March 2017 — also relied on fabricated evidence. He said images intended to prove that a bomb containing sarin was used in the attack showed fragments of a conventional munition, and samples appeared to have been doctored.
Here’s what you’ll need to get started. Directions Take a pipe cleaner and wrap it around a popsicle stick. For my three year old, I started by wrapping the pipe cleaner around the stick once in order to secure it. Then I handed her the pipe cleaner while I held the stick. This made it easier for her to wrap it around. For each stick you and your toddler or preschooler can decide if you want to do different colour pipe cleaners or all the same colour. After she started to get the hang of wrapping the pipe cleaner around I let her hold the popsicle stick and try to wrap it around it herself. Don’t under estimate how simple this action is. For a toddler or preschooler wrapping around can be quite challenging. That is what makes this craft such a great activity to strengthen fine motor skills and hand eye coordination. Once you have wrapped 4 popsicle sticks with pipe cleaners, shift the pipe cleaners around so that the center of the popsicle sticks is clear (see photo below for reference). This is where you will glue the sticks together. Add lots of glue to the center of the sticks and stack one on top of the other forming a cross. Push down and hold for about 30 seconds. Repeat with the other two sticks. Leave the snowflake on a table to dry for at least 1 hour before moving it. WILL YOU TRY PIPE CLEANER AND POPSICLE STICK SNOWFLAKES WITH YOUR TODDLER OR PRESCHOOLER? Pin it for later!
Filed 4/22/14 P. v. Butler CA3 NOT TO BE PUBLISHED California Rules of Court, rule 8.1115(a), prohibits courts and parties from citing or relying on opinions not certified for publication or ordered published, except as specified by rule 8.1115(b). This opinion has not been certified for publication or ordered published for purposes of rule 8.1115. COPY IN THE COURT OF APPEAL OF THE STATE OF CALIFORNIA THIRD APPELLATE DISTRICT (San Joaquin) ---- THE PEOPLE, C072594 Plaintiff and Respondent, (Super. Ct. No. SF113454A) v. TIRELL BUTLER, Defendant and Appellant. A jury convicted defendant Tirell Butler of transportation of cocaine (count two), transportation of cocaine base (count four), and transportation of ecstasy (count five). The trial court declared a mistrial on three other counts and they were ultimately dismissed. The court found defendant had two prior strike convictions, had served two prior prison terms, and had a 2001 prior conviction for cocaine base for sale. Pursuant to Proposition 36, the Three Strikes Reform Act of 2012, the court sentenced defendant to 1 13 years on count two and imposed sentences on counts four and five, but stayed them pursuant to Penal Code section 654. On appeal, defendant contends the trial court prejudicially erred in instructing the jury on moral turpitude, on consciousness of guilt, and in refusing to give his proffered pinpoint instruction on third party culpability. Finding no merit to any of the contentions, we affirm the judgment. FACTS AND PROCEEDINGS Around 10:00 or 11:00 p.m., on November 21, 2009, Stockton Police Officers Carlos Vina and Mitch Tiner were on patrol looking for Syldarius Grant (Syldarius), a parolee at large, when they stopped a car Syldarius was known to drive. As Officer Vina approached the car, the driver yelled, “I’m not the person you’re looking for.” The driver was defendant, who is Syldarius’s cousin, and he admitted he was on parole. A search of a leather jacket defendant was wearing disclosed packets of cocaine, cocaine base, and ecstasy. Expert testimony established the drugs were possessed with intent to distribute. Defendant testified that about 8:00 p.m. on the evening in question, he had driven his van from a hospital where his wife had surgery to the home of his uncle, Sylvester Grant (Sylvester), to check on him because he had cancer. Upon arriving at Sylvester’s home, defendant locked the keys inside the van. Sylvester gave defendant permission to borrow his car and defendant got the keys from Syldarius, who also used the car. Inside the car was a leather jacket which defendant put on because it was cold and the car had no heat. Defendant picked up a friend of his sister’s and drove her to his sister’s home in Manteca. When defendant got back to Stockton, he was stopped by Officers Vina and Tiner. Officer Vina found drugs in the leather jacket, and defendant told Officer Tiner they were not his. Defendant knew that Syldarius was wanted and that he was a gang member who sold drugs. Although defendant knew the jacket belonged to 2 Syldarius, he had no idea there were drugs inside it. Defendant admitted being convicted of two robberies in 1993 and a felony in 2001 which involved moral turpitude. In rebuttal, Officer Vina testified that when he confronted defendant with the drugs, defendant admitted they were his, but only were possessed for personal use. DISCUSSION I Instructions Regarding Moral Turpitude Defendant contends the trial court made two instructional errors regarding his prior felony conviction in 2001. First, by leaving the jury to decide whether his prior 2001 conviction involved moral turpitude; and second, by instructing the jury that “a crime of moral turpitude is one that bears a rational relationship to a witness’s readiness to lie.” We reject both claims. Prior to trial, defendant moved to prohibit the prosecution from using any of his prior convictions for impeachment. The court denied the motion, but agreed with defendant’s request to sanitize the 2001 prior as a “felony crime of moral turpitude.” During defendant’s testimony, he admitted that his 2001 felony conviction was for a crime involving moral turpitude. The court instructed the jury, per CALCRIM No. 316, as follows: “If you find that a witness has been convicted of a felony, you may consider that fact only in evaluating the credibility of the witness’ testimony. [¶] The fact of a conviction does not necessarily destroy or impair a witness’ credibility. It is up to you to decide the weight of that fact and whether that fact makes the witness less believable.” In a separate instruction, given immediately after the giving of CALCRIM No. 316, the court defined moral turpitude “as a readiness or willingness to do evil.” Defendant argues that CALCRIM No. 316, as given, permitted the jury to determine whether his prior conviction in 2001 involved moral turpitude. Defendant 3 misunderstands the instruction. It is true that the determination of whether a criminal offense involves moral turpitude is a question of law for the court, not the jury. (People v. Gray (2007) 158 Cal.App.4th 635, 640.) However, it is likewise true that there is nothing in CALCRIM No. 316 which permits the jury to determine whether defendant’s 2001 conviction involved moral turpitude. Indeed, the only determination the instruction permits the jury to make is to find whether defendant has “been convicted of a felony,” and if so, how to use that evidence. The instruction defining moral turpitude was given, without objection by defendant, in anticipation that the jury would ask for such an instruction. Hence, the instructional error perceived by defendant is nonexistent. Additionally, we note that even if the instruction could be read to permit the jury to determine whether defendant’s prior conviction involved moral turpitude, the error would have been to defendant’s benefit because such a reading would afford the jury the opportunity to find that the prior did not involve moral turpitude, which, in the eyes of the jury, would have rendered the prior less suitable for showing a readiness to do evil. Defendant can have no reasonable complaint about an asserted error which was to his benefit. During deliberations, the jury asked for a further definition of “moral turpitude.” The court responded, “A crime of moral turpitude is one which bears a rational relationship to a witness’ readiness to lie.” Defendant argues the court’s response was “incorrect” because it “limit[ed] moral turpitude to crimes which bear a rational relationship to a witness’s readiness to lie.” The instruction is and was correct. As the California Supreme Court has noted, “[T]he law provides that any criminal act or other misconduct involving moral turpitude suggests a willingness to lie . . . .” (People v. Contreras (2013) 58 Cal.4th 123, 157, fn. 24.) “Possession of drugs for sale, which involves the intent to corrupt others, is conduct involving moral turpitude.” (People v. Harris (2005) 37 Cal.4th 310, 337.) Accordingly, the court’s response was correct. 4 II CALCRIM NO. 362 Defendant contends the trial court’s instructing the jury per CALCRIM No. 362 “violated [his] constitutional rights to due process by improperly singling out his [trial] testimony for special scrutiny and denying him a meaningful opportunity to present a defense.” We reject the contention. Defendant faults the trial court for giving the following version of CALCRIM No. 362: “If the defendant made a false or misleading statement relating to the charged crime, knowing the statement was false or intending to mislead, that conduct may show that he was aware of his guilt of the crime and you may consider it in determining his guilt.” According to defendant, the problem with this instruction is that it has “potential scope for application” to his trial testimony. We disagree. The version of CALCRIM No. 362 given by the trial court said: “If the defendant made a false or misleading statement before this trial relating to the charged crime, knowing the statement was false or intending to mislead, that conduct may show he was aware of his guilt of the crime and you may consider it in determining his guilt.” (Italics added.) Accordingly, the instruction given precluded its application by the jury to defendant’s trial testimony. III Proposed Instruction on Third Party Culpability Defendant contends the trial court “violated [his] right to due process and a jury trial when it refused to instruct the jury with a requested pinpoint instruction on third party culpability.” We disagree, concluding that defendant has forfeited the issue by failing to establish that the court refused to give the proposed instruction, and, even if the court rejected the instruction, defendant suffered no harm. 5 Defendant’s defense was that the jacket he was wearing in which the drugs were found belonged to Syldarius, and that defendant was unaware of their presence. Accordingly, the court instructed the jury as follows: “Evidence has been offered that a third party is the perpetrator of the charged offense. It is not required that the defendant prove this fact beyond a reasonable doubt. In order to be entitled to a verdict of acquittal, it is only required that such evidence raise a reasonable doubt in your minds of the defendant’s guilt.” Defendant composed the following instruction, which he characterizes as a pinpoint instruction that was not given: “You have heard evidence that Syldarius Grant committed the offenses with which the defendant is charged. The defendant is not required to prove Syldarius Grant’s guilt. It is the prosecution that has the burden of proving the defendant guilty beyond a reasonable doubt. Therefore, the defendant is entitled to an [sic] verdict of not guilty if you have a reasonable doubt as to the defendant’s guilt. Evidence that another person committed the charged offenses may by itself leave you with a reasonable doubt. [¶] If after considering all of the evidence, including any evidence that another person committed the offense, you have a reasonable doubt that the defendant committed the offense you must find the defendant not guilty.” As defendant points out, there is no discussion in the reporter’s transcript regarding the third party culpability instruction. Defendant’s proposed instruction is found in the clerk’s transcript under a section labeled “Instructions Not Given.” Nothing in the record shows why the instruction was not given -- the court could have refused to give the instruction or defendant could have withdrawn the instruction after further consideration. On appeal, “ ‘ “[w]e must indulge in every presumption to uphold a judgment, and it is defendant’s burden on appeal to affirmatively demonstrate error -- it will not be presumed. [Citation.]” [Citations.]’ [Citation.]” (People v. Sullivan (2007) 151 Cal.App.4th 524, 549.) Defendant has not met his burden of establishing that the 6 court refused to give the instruction rather than the instruction having been withdrawn for some other reason. Accordingly, the issue is forfeited for appeal. Even if considered on the merits, defendant’s argument would fare no better. Defendant’s complaint with the instruction given was that it did not name Syldarius as the third party. Although the instruction did not specifically name Syldarius, defendant testified the jacket belonged to Syldarius, and during argument, counsel expressly identified Syldarius as the “third party” referred to in the instruction on third party culpability. It is simply inconceivable that the jury did not relate the third party in the instruction to Syldarius; hence defendant suffered no harm. DISPOSITION The judgment is affirmed. HULL , J. We concur: BLEASE , Acting P. J. DUARTE , J. 7
Protect Your Children with a Child Abuse Lawyer in Columbia, MO There’s no worse feeling than suspecting your child has been neglected or abused. In such tense cases, it’s crucial to have an experienced child abuse lawyer in Columbia, MO on your side. At Rutter and Sleeth Law Office, we deal with a variety of issues related to child crime law, including child custody suits, child support disputes, and visitation rights. Let us get to work protecting your family and defending your child’s rights as soon as you call. Our Child Law Services Whether you’re seeking an adoption or dealing with a paternity suit, cases involving children are emotionally draining for all parties involved. We understand that in such situations, you need a compassionate, sympathetic lawyer who will listen to your concerns. Your lawyer must also have a thorough understanding of child crime law to give your family the best possible outcome. The lawyers at Rutter and Sleeth Law Office strive to provide all of the above as we help you with the following services: Paternity Child neglect Child custody Child abuse Child support disputes Visitation We also offer adoption legal services, which means we can help you with: Foster care adoption International adoption Private adoption Private adoption agencies Public adoption agencies Stepparent adoption Find Support for Your Family During this stressful time, Rutter and Sleeth provides empathetic legal services as we fight for your family however we need to. With 50 years of legal experience, we have the training and background to defend your child and family. If for any reason we can’t help you, we’ll help you find someone who can. We keep your best interests at heart as we pursue a favorable outcome. When you need an experienced lawyer contact our office for your free case evaluation. You can call us at either of the numbers listed on our contact page, or fill out our online form. We’ll do our best to respond to you within 24 hours.
The elegant organization of nucleic acids, predominantly DNA, into chromatin serves essential structural and regulatory roles in eukaryotic cells. This beautiful architecture allows for an expansion of the underlying genetic information by overlaying a spectrum of epigenetic controls. The interplay between genome accessibility, chromatin posttranslational modifications and transcriptional activity is a critical hub of gene expression regulation. Fundamental to many disease processes is a dysregulation of transcription that underlies the critical role regulated gene transcription plays in normal development physiology and homeostasis. A major focus, of the Archer group has been an understanding of how epigenetic enzymes, including chromatin remodeling proteins such as the SWI/SNF complex, work with transcription factors, such as the glucocorticoid receptor, to respond to environmental cues, both internal and external. Many of our studies have utilize the glucocorticoid receptor, a ligand-activated transcription factor that has important functions in many aspects of mammalian physiology including development, reproduction, immune response, cardiac function, and energy metabolism. Consistent with the broad physiological functions, dysregulation of GR activity is a major factor in health and disease. In this way we hope to understand the function of both the receptor and the requirement for chromatin remodeling and other epigenetic enzymes in these processes. The organization of DNA as chromatin, and its assembly around four core histones, as well as a linker histone, H1, provides a platform for studying mechanisms of gene transcription that relate to environmental responses as well as developmental cues important in determining prepotency of embryonic stem cells. The advent of both embryonic stem cells as well as induced pluripotency stem cells (iPSCs) have opened a significant avenue of experimental approaches to understand both normal and disease states in humans. Many of the studies with pluripotent stem cells have affirmed a major determinant of a role for epigenetics as a mechanism by which the DNA residing in all cells can have specific features of pluripotency. Research pursued in the chromatin and gene expression group within the ESCBL aligns with the NIEHS strategic plan themes one, two and three and multiple goals within those three themes particularly with respect to basic biological research, outreach communications and engagement, environmental health disparities and environmental justice, the professional pipeline, and greater workforce diversity and training in capacity building in global health. Together these studies allow us to fulfill the mission of the NIEHS to improve an understanding of environmental impact on human health and development. A major focus, our research program has been our attempts to understand how chromatin remodeling proteins such as the SWI/SNF complex work with transcription factors, such as the glucocorticoid receptor, to respond to environmental cues, both internal and external. Many of our previous studies made use of the MMTV model promoter which was crucial in demonstrating that the chromatin remodeler BRG1 was critical for GR transcriptional activity. However, subsequent studies demonstrated that GR binds to thousands of sites scattered throughout the genome, representing diverse chromatin landscapes that elicit the hormone response. To expand our studies, Dr. Jackson Hoffman, and Mr. Kevin Trotter, utilized a variety of genome-scale experiments (ChIP-seq, ATAC-seq, RNA-seq, and Start-seq) in human breast cancer cells to identify GR and BRG1 binding sites or peaks throughout the genome and to interrogate the characteristics of the underlying chromatin. Our study reveals that the pattern of BRG1 interaction at GR peaks defines three distinct classes of GR binding site. In contrast to models based on binding sites in at a restricted number of well-established model hormone responsive genes, BRG1 interacts with a significant subset of GR prior to hormone exposure. GR peaks that are pre-occupied by BRG1 are uniquely enriched for active chromatin and are associated with active enhancers and TSSs. The peak classes we define also have distinct patterns of transcription factor motif enrichment and pioneer factor binding. Importantly, BRG1 binding prior to hormone exposure was predictive of GR interaction with pioneer factors. Furthermore, reduction of BRG1 expression blocked hormone-dependent recruitment of pioneer factors to GR binding sites. Finally, we show that BRG1 is required for a robust and proper hormone-induced transcriptional response. Taken together, these findings demonstrate that BRG1 is critical to both pre-pattern GR binding sites and to facilitate hormone-dependent chromatin and transcription factor dynamics. (Hoffman et al., 2018 https://elifesciences.org/articles/35073)
SkySports Manchester City manager Pep Guardiola believes rivals Manchester United are still a "great team" and it's too early in the season to start judging teams and their managers. Watch Next. England v India: T4 D2 highlights · Watch Now · Huge crash for SkySports Manchester United are hoping to avoid their worst start to a season since 1987 when they visit Burnley on Sunday. Jose Mourinho walked out of his press conference after Monday's 3-0 home defeat to Tottenham shouting "Respect!" in response to some of and more » SkySports Nottingham Forest have signed former Manchester United and Celtic defender Saidy Janko on loan from FC Porto. The Switzerland international, who came through the ranks at FC Zurich, moves to Forest for the remainder of the 2018-19 season. and more » Tottenham took control of the second half at Manchester United, burying three goals in the Theatre of Dreams to up the pressure on Jose Mourinho. The ESPN FC guys answer your tweets on Jose Mourinho's future, Tottenham's squad and much more. Tottenham manager Mauricio Pochettino says his players... Jose Mourinho willing to sell key Man United maestro should club receive offer of €100M The post Jose Mourinho willing to sell key Man United maestro should club receive offer of €100M appeared first on CaughtOffside . SkySports The final episode from the second series of our Transfer Talk podcast is here! Host Tom White is joined by Sky Sports News reporter Dharmesh Sheth and football writer Pete Hall to dissect the final deals as the window closes across Europe on August 31. and more » SkySports Manchester United manager Jose Mourinho has given an impassioned defence of his managerial record, describing himself as 'one of the greatest managers of all time'. Watch Next. SPB MOURINHO OOYALA.mxf · Watch Now · Sarri: Howe will make his Jose Mourinho referred to the writing of renowned philosopher Georg Wilhelm Friedrich Hegel when discussing his position at Manchester United today. The Portuguese boss has never been too far away from the headlines but as of late, it seems as though he cannot keep himself out of the spotlight –... SkySports Jose Mourinho says Manchester United defender Like Shaw has earned his recall to the England quad. Shaw, who was omitted from England's World Cup squad, has found a place in Gareth Southgate's set-up for the games against Spain and Switzerland. and more » SkySports Manchester United manager Jose Mourinho has given an impassioned defence of his managerial record, describing himself as 'one of the greatest managers in the world'. Watch Next. Huge crash for Ericsson · Watch Now · Jose: I'm one of the world's Tottenham manager Mauricio Pochettino has revealed his disappointment after the first half at Old Trafford on Monday and insists his team must improve. Spurs have won all three of their games at the start of the 2018-19 Premier League season, most recently dismantling Jose Mourinho’s United 3-0 a... MANCHESTER UNITED boss Jose Mourinho was on the warpath today following their 3-0 defeat to Tottenham on Monday. But the club’s Twitter has intriguingly chosen not to publicise his quotes on himself, Spurs and Liverpool’s Jurgen Klopp. Mauricio Pochettino has said Tottenham must improve on their performance in the groundbreaking 3-0 win at Manchester United on Monday, warning his players they will 'crash' against Watford if they start to believe the hype. Shaka Hislop says the things Jose Mourinho is saying and doing are about separating himself from Manchester United's struggles. The ESPN FC panel talk the parameters that will have to fall into place for Manchester United to entertain the idea of sacking Jose Mourinho. MANCHESTER, England -- Luke... Barcelona are the clear favourites in Group B of the Champions League, but the FC crew think Tottenham could struggle to finish ahead of Inter Milan. Tottenham took control of the second half at Manchester United, burying three goals in the Theatre of Dreams to up the pressure on Jose Mourinho. J... Manchester United manager Jose Mourinho has taken a pop at Spurs fans for a lack of success after they mocked him during Monday night’s game. Mauricio Pochettino masterminded the downfall of the Red Devils at Old Trafford on Monday, as his team emerged as 3-0 winners on the night thanks to a brac... Manchester United manager Jose Mourinho seemed to attempt a little dig at Liverpool boss Jurgen Klopp about over-celebrating. The Portuguese tactician has a history of using the press to his advantage, using outlandish remarks to take the focus off his team and his players and onto himself. While... • Mourinho uses German philosopher to make his point • Manchester United manager aims barb at Spurs fans José Mourinho has described himself as “one of the greatest managers in the world” and quoted the philosopher Hegel to defend the stance. Manchester United’s manager made the claim when asked... Telegraph.co.uk Jose Mourinho has declared himself “one of the greatest managers in the world” as he launched another grandiose defence of his record in the face of mounting pressure at Old Trafford. Just days after reacting to United's 3-0 capitulation by Spurs by and more » Manchester United boss Jose Mourinho believes that last year’s second-place Premier League finishes ranks as one the ‘greatest achievements’ of his career. The Portuguese tactician has one of the most impressive managerial CV’s in European football having won the Champions League twice and numero... Manchester United manager Jose Mourinho gave a rather telling answer to a question in his press conference today. When asked about his love for United, the Portuguese pretty much just responded by talking about himself and his own greatness. Mourinho is under growing pressure at the moment after... Manchester United may want to tread carefully as they consider Jose Mourinho’s future at the club after a difficult start to the season. The Portuguese looks a man under pressure after appearing grumpy and unsettled in pre-season, with his side now losing two of their three opening matches in the... The ESPN FC panel talk the parameters that will have to fall into place for Manchester United to entertain the idea of sacking Jose Mourinho. MANCHESTER, England -- Manchester United manager Jose Mourinho has branded himself "one of the greatest managers in the world" while launching a fierce def... Manchester United midfielder Nemanja Matic will have made himself very popular indeed with Red Devils fans after this brutal dig at his old club Chelsea. The Serbia international notably swapped Stamford Bridge for Old Trafford last season in a somewhat controversial move given the rivalry betwee... SkySports Edwin van der Sar fears Manchester United could struggle this season after their slow start to the campaign. Watch Next. 'Shaw's England's best left-back' · Watch Now · Hughes backs Jose on issue of respect · Watch Now · 'Shaw can get back to his best'. Manchester United reportedly have one crucial edge over rivals Manchester City in any transfer battle for Ruben Neves this January. The young Portuguese star has been linked strongly with a move away from Wolves in the near future after shining in the Championship last season and also making a gr... SkySports Sacking Jose Mourinho would be "terrible" for Manchester United who would struggle to recruit a better replacement, according to Paul Merson. Merson thinks the club's failure to sign a centre-back in the summer - and issues with their long-term and more » Manchester United manager Jose Mourinho was snapped taking a look at his side’s next Premier League opponents Burnley in what could be a crucial scouting mission. The Red Devils travel to Turf Moor this Sunday for what is rumoured by some to be a pivotal match for Mourinho in terms of keeping his... Ahead of each round of fixtures in the Premier League, W2W4 looks at the main storylines to keep an eye on. Here is what is in store for Matchday 4. Can Burnley take advantage of Man United's frailty? The worst thing about Jose Mourinho's post-Tottenham outburst, from his detractors' point of vie... Today’s fluff is sparse The international transfer window shuts today, although you could be forgiven for thinking that it closed when Premier League clubs stopped doing business earlier this month. After all, the Mill’s lead story is Blackburn Rovers rejecting West Brom’s £5m offer for Bradley D... Manchester United midfielder Paul Pogba and his agent Mino Raiola are reportedly doing everything they can to seal a January transfer to Barcelona this season. That’s according to Spanish outlet Don Balon, who also claim Barca look likely to try their luck with a bid for Pogba again this winter.... Michael Owen is backing Manchester United to return to winning ways at Burnley on Sunday afternoon. The Red Devils have made a disappointing start to the Premier League season despite finishing in second place last term. Manchester United were unconvincing 2-1 winners against Leicester City in th... The FC panel are cautiously optimistic of Manchester United's chances of advancing from Group H, indicating Jose Mourinho must fix their current problems fast. Ronaldo has backed Jose Mourinho to turn things around at Manchester United, although he believes the Champions League will be staying at... ESPN FC's Alexis Nunes and Paul Mariner square off in predicting every Premier League fixture of week 4's action. Jose Mourinho is under huge pressure at Manchester United. More misery at Burnley this Sunday could leave his job under severe threat. Back-to-back defeats, including the biggest home... Manchester United are in talks with Anthony Martial’s agent about a new deal for the striker, according to reports in the British media. BBC Sport is reporting that the Red Devils are keen to get the 22-year-old to sign a new contract at Old Trafford, as his current deal is due to expire at the ... Manchester United’s executive vice-chairman Ed Woodward is reportedly so concerned by the team’s poor form that he’s taken to watching Jose Mourinho’s training sessions. The Red Devils have made a poor start to the season, losing two of their opening three Premier League games – the first time th... Sadio Mane has revealed that he turned down a move to Manchester United before joining Liverpool FC because it was “not right”. The Senegal international has established himself as one of the Premier League’s top attacking players since moving to Anfield from Southampton back in 2016. However, Ma... SkySports All the top stories and transfer rumours from the back pages of Friday's national newspapers THE GUARDIAN. Manchester United have denied talk of a rift between manager Jose Mourinho and executive vice-chairman Ed Woodward. and more » SkySports Luke Shaw is England's best left-back, says Ian Wright, after the Manchester United defender was recalled to Gareth Southgate's squad for the upcoming Nations League games. The 23-year-old has played the entirety of United's three Premier League games and more » Bryan Robson is fully expecting to see Manchester United bounce back from their tricky start under Jose Mourinho this season. The Red Devils slumped to a surprise 3-0 loss to Tottenham Hotspur at Old Trafford on Monday night as they suffered a blow to their title hopes. Manchester United have str... Bryan Robson has told Manchester United that they must simply focus on getting the three points when they take on Burnley in the Premier League on Sunday. The Red Devils are already under pressure this season after having slumped to back to back defeats by Brighton and Tottenham Hotspur to heap t... Martin Keown has challenged Jose Mourinho to turnaround Manchester United’s poor start to the new Premier League season. The Red Devils have made a disappointing start to the Premier League season despite finishing in second place in the Premier League last term. Manchester United were unconvinci... Ryan Giggs has challenged Manchester United to beat Burnley on Sunday to “shut up a few people”. The Red Devils have made a poor start to the season after collecting three points from their opening three Premier League games. Manchester United were 2-1 winners against Leicester City in their seas... Martin Keown has urged Jose Mourinho to support struggling Manchester United stars such as Victor Lindelof. The Red Devils suffered a surprise 3-0 loss to Tottenham Hotspur at Old Trafford on Monday to continue their poor start to the season. Manchester United struggled defensively as Lindelof an... Martin Keown believes Jose Mourinho has been too honest at Manchester United. The Red Devils boss is coming under pressure following a disappointing start to the new Premier League season. Manchester United limped to a 2-1 win over Leicester City in their season opener at Old Trafford earlier in... SkySports Charlie Nicholas provides us with his Champions League verdict after tough draws for Tottenham, Liverpool and Manchester United while Manchester City remain the top contenders for the trophy after a favourable draw. Being placed with Barcelona, PSV and more » It says much about what the Champions League group stage has become that even a draw as engaging as this is almost certain to have no impact on the defining themes of the season; that most of the big games like Liverpool-Paris Saint-Germain and Barcelona-Tottenham simply don't carry the same sens... Bryan Robson has warned Manchester United players that they must stick together as they look to try and turn around their stuttering form. The Red Devils have found themselves under intense pressure in recent weeks after they slumped to back to back defeats in the Premier League under Jose Mourin... Paul Parker believes that Manchester United should be seriously considering the future of Jose Mourinho at Old Trafford. The Portuguese coach has found himself under intense pressure at Old Trafford in recent weeks after his side lost their second straight game in the Premier League. Manchester U... SkySports Cristiano Ronaldo is set for a return to Old Trafford after Juventus were drawn against Manchester United in the Champions League group stage. Joining United and Serie A champions Juventus in a difficult Group H are Valencia and Young Boys. and more » Spanish football journalist Sid Lowe has slated the idea of Zinedine Zidane being drafted in to replace Jose Mourinho at Old Trafford. The Red Devils have got off to an abysmal start in the new Premier League season, losing back to back games against Brighton and Tottenham to fall six points behi... The Zinedine Zidane to Manchester United talk just isn’t going away as Jose Mourinho’s future continues to be the focus of the season early on. The Red Devils have made a poor start with two defeats from their opening three Premier League matches, with the s**t really hitting the fan in the 3-0 h... SkySports Manchester United forward Alexis Sanchez has been left out of Chile's squad for two friendlies next month because his club need him, coach Reinaldo Rueda has said. United have had their worst start to a Premier League campaign since the inaugural and more » • Woodward has made several visits to United’s training ground • Vice-chairman also in telephone contact with the Glazer family Ed Woodward has been making an increasing number of visits to Manchester United’s training ground over the past two weeks with suggestions from some quarters José Mourin... SkySports Paul Merson is back with his latest round of Premier League predictions for this weekend. Early pace-setters Liverpool travel to the King Power Stadium on Saturday to take on Leicester, live on Sky Sports from 11.30am, before five 3pm kick-offs. On SkySports Mark Hughes has backed Jose Mourinho over the Manchester United manager's claim that he deserves more respect from the media. Watch Next. 'Fulham must follow own style' · Watch Now · Hughes: McCarthy can be England No 1 · Watch Now. Hughes Telegraph.co.uk If fans of Arsenal, Burnley, Chelsea, Liverpool, Manchester City, Manchester United and Tottenham were feeling slightly left out of this week's extra-time-less, low-key cup-upset action, then they can cheer right up, because the third-round draw for and more » Shaka Hislop says the things Jose Mourinho is saying and doing are about separating himself from Manchester United's struggles. It has been reported this week that Anthony Martial is set to sign a new five-year deal at Manchester United, despite the club having the option to extend his current co... The guys respond to your tweets about Steve Nicol and Paul Mariner replacing Jose Mourinho at Man United, expected goals and Tottenham's success. Paul Mariner assesses whether or not London is losing something as clubs leave famous old stadiums for brand new homes. Tottenham have asked the EFL bo... Charlie Nicholas provides us with his Champions League verdict after tough draws for Tottenham, Liverpool and Manchester United while Manchester City remain the top contenders for the trophy after a favourable draw. Former Manchester United goalkeeper Peter Schmeichel believes Mourinho’s men face a huge challenge against Juventus in the group stage of the Champions League. The Italian giants have contested two of the last four Champions League finals, losing out to Barcelona and Real Madrid respectively in 2... The 2018-19 Champions League group stage, which begins next month, will more than a few several eye-catching games after Thursday's draw pitted some of Europe's biggest clubs against each other. Group H sees a reunion for Cristiano Ronaldo and Paul Pogba with Manchester United and Juventus respec... Liverpool will host Chelsea while Frank Lampard's Derby County will visit Manchester United following the third-round draw for the Carabao Cup held on Thursday. Holders of the most League Cup titles at eight, Liverpool last met Chelsea in the 2015 semifinals, a 2-1 aggregate win for the Blues. L... • Tottenham ask for third-round tie to be played at Stadium MK • Liverpool host Chelsea while Derby face Manchester United Tottenham Hotspur have asked for special dispensation to play their Carabao Cup third round tie against Watford at Stadium MK as their new stadium will not be ready for the f... FC's Paul Mariner finds it tough to choose Man United to advance from Group H, noting the current negative climate of the club. Craig Burley says Cristiano Ronaldo's goalless start for Juventus is of no concern, offering a reminder Ronaldo has a recent history of dry spells. Juventus' general man... THE CHAMPIONS League draw has taken place and the draw sees Liverpool, Manchester United and Tottenham Hotspurs all handed difficult groups, while Manchester United has been given a relatively simple group, but who presented the draw on Thursday from Monaco? League Cup Third Round Draw: Chelsea handed tricky Liverpool draw as Man United given easy route to next round The post League Cup Third Round Draw: Chelsea handed tricky Liverpool draw as Man United given easy route to next round appeared first on CaughtOffside . Liverpool, Manchester United and Tottenham received the toughest draws for the group stage of the Champions League this evening. The Champions League group stage draw has thrown together some of the best clubs in Europe at the earliest possible time in this years competition, with Spurs, United a... SkySports Cristiano Ronaldo is set for a return to Old Trafford after Juventus were drawn against Manchester United in the Champions League group stages. More to follow. Also See: Champions League draw reaction · Ronaldo wins UEFA goal of season award · UEFA Manchester United fans have reacted emotionally to Cristiano Ronaldo’s return to Old Trafford after the Champions League draw. The Red Devils have been matched with Juventus in their group, meaning Ronaldo is set to return to United for just the second time since he left the club in 2009. MORE: E... Gab Marcotti speaks to Alexis Nunes about the proposed introduction of VAR in the Champions League and how it will be used. With a Spanish team winning each of the last five Champions League titles, is this the year their dominance comes to an end? Juventus will face Manchester United in the Cham... Manchester United executive vice-chairman Ed Woodward is now understood to be in full control of transfers at the club, according to reports. Woodward’s relationship with manager Jose Mourinho has been under the spotlight of late, particularly as the club have now made such a poor start to the se... When Anthony Martial’s camp again sat down with Manchester United after what had been a difficult and uncertain summer for the French star, one thing was made clear: The 22-year-old would be given full support by the club in the future. Shaka Hislop says the things Jose Mourinho is saying and doing are about separating himself from Manchester United's struggles. Sid Lowe joins the FC panel to address the rumours linking Zinedine Zidane to Manchester United. The ESPN FC panel talk the parameters that will have to fall into place... Real Madrid president Florentino Perez has reportedly received a phone call in the last 24 hours from Manchester United star Paul Pogba regarding his transfer plans. Although it is not made clear if this was a direct call or one between Pogba’s agent and the Madrid chief, Don Balon state the Fran... Manchester United legend Gary Neville has sent a message of congratulations to Luke Shaw on Twitter after his recall to the England squad today. The outspoken pundit is clearly thrilled to see a top young player from his old club get a look-in at international level after a long absence. Well don... A few defiant Manchester United fans seem determined not to buy all the ‘fake news’ about manager Jose Mourinho. The Portuguese tactician is not having the best of times at the moment after two defeats from United’s opening three Premier League games, which have followed some public grumbling abo... SkySports Luke Shaw has been recalled by England for the forthcoming matches against Spain and Switzerland, with his Manchester United team-mate Ashley Young left out by manager Gareth Southgate. Shaw has not played for England since appearing as a and more » Jose Mourinho tells ESPN FC that the World Cup was the perfect habitat for Paul Pogba as he could 'only think about football.' Former director of football for PSG Patrick Kluivert shares his thoughts on Kylian Mbappe's World Cup and his chances of winning a Ballon d'Or. Didier Deschamps has sugge... Former England striker Ian Wright says the FA deserve credit for England's run to the semi-finals of the World Cup. ESPN FC's Alexis Nunes and Steve Nicol assess the English FA's consideration to bid for the 2030 World Cup. Manchester United defender Luke Shaw has been recalled to the England squ... Three Lions take on Spain and Switzerland during the upcoming international break The post England squad announcement: Man Utd, Liverpool stars get nod as Southgate addresses dropped trio appeared first on CaughtOffside . Barcelona are reportedly convinced they have the groundwork in place to seal a future transfer deal for Manchester United midfielder Paul Pogba. The France international could be on his way to the Nou Camp in a similar way that Philippe Coutinho wound up there from Liverpool last season, with the... Jose Mourinho tells ESPN FC that the World Cup was the perfect habitat for Paul Pogba as he could 'only think about football.' Former director of football for PSG Patrick Kluivert shares his thoughts on Kylian Mbappe's World Cup and his chances of winning a Ballon d'Or. France coach Didier Descha... The latest transfer rumours from around the world. Things change in the blink of an eye in football. The Football Whispers Index takes the latest transfer rumours and gives them a score out of five; the higher the score, the more realistic and reliable the Whisper. Here are today's top five emerg... Manchester United manager Jose Mourinho is reportedly happy about Anthony Martial being offered a new contract at Old Trafford. This is according to the Daily Mirror, and comes as something of a shock given all that has gone on between the manager and the player in the last few months. Martial ha... Burnley chairman Bob Lord took raised hackles to new heights with his comments about Manchester United after Munich It’s often said José Mourinho … don’t worry, this isn’t another column about José Mourinho it’s often said he could start a 22-strong media‑accredited brawl in an empty press room.... Liverpool star Sadio Mane has given his brutal reason for rejecting a transfer to rivals Manchester United while he was still at Southampton. The Senegal international, who has gone on to become a major player in Jurgen Klopp’s side, says he held talks over joining United but decided against the... Manchester United midfielder Paul Pogba has reportedly informed close friends of his reason for wanting a transfer to Barcelona. Despite interest from Real Madrid this summer, the France international is said to favour Barcelona due to a long-running desire to play alongside Lionel Messi, accordi... Former England striker Ian Wright says the FA deserve credit for England's run to the semi-finals of the World Cup. ESPN FC's Alexis Nunes and Steve Nicol assess the English FA's consideration to bid for the 2030 World Cup. Manchester United defender Luke Shaw is set to be recalled to the England... Odds have been slashed on former Chelsea manager Antonio Conte replacing Jose Mourinho at Manchester United, just as he did at Stamford Bridge two years ago. The Italian tactician was brought in at Chelsea in the summer of 2016, taking over after Guus Hiddink had taken the job in a caretaker role... Liverpool on harder side of Thursday’s draw Manchester City, Manchester United and Spurs also involved Liverpool, runners-up in the Champions League last season, will be in pot three in Thursday afternoon’s group-stage draw after Benfica saw off Paok Thessaloniki in the play-offs. Had Benfica los... Manchester United have reportedly lined up six top candidates as potential replacements for Jose Mourinho in the event that the team’s form continues to spiral downwards. The Red Devils have made a poor start to the season with two defeats from their first three Premier League games, with the 3-0... Gary Neville has criticised Marcus Rashford’s disappointing performances for Manchester United so far this season. The England international started Manchester United’s 2-1 win against Leicester City in their Premier League opener at Old Trafford at the start of the campaign. Jose Mourinho brough... Gary Neville has admitted that he can’t defend Manchester United trio Alexis Sanchez, Marcus Rashford and Anthony Martial any more. The Red Devils have made a difficult start to the Premier League campaign to leave Manchester United in turmoil despite a second-placed finish last term. Sanchez mov... Paul Pogba has told his Manchester United team-mates “not to worry” despite their second straight defeat in the Premier League this week. Pogba was unable to prevent the Red Devils from slipping to a surprise 3-0 loss to Tottenham Hotspur at Old Trafford on Monday night as Jose Mourinho’s men slu... Paul Pogba has admitted that Manchester United’s defeat by Tottenham Hotspur was “bizarre” as he vowed to help the Red Devils bounce back. Pogba was unable to prevent the Red Devils from slipping to a disappointing 3-0 loss to the north London side at Old Trafford on Monday night as they slumped... Sam Allardyce believes that Paul Pogba is yet to produce consistent form for Manchester United. The French midfielder re-signed for the Red Devils in a big-money deal back in the summer of 2016 when Jose Mourinho took over but most Manchester United fans would agree that he is yet to hit top gear... Ryan Giggs has urged Jose Mourinho and his Manchester United squad to ignore the criticism ahead of their trip to Burnley on Saturday. The Red Devils slumped to successive Premier League defeats on Monday night following a 3-0 loss to Tottenham Hotspur at Old Trafford to heap pressure on Mourinho... Gary Neville doesn’t believe Manchester United should sack Jose Mourinho despite a dreadful start to the season. Mourinho set the tone during pre-season with his downbeat attitude when speaking to the British media on tour in the United States. The Manchester United manager was unhappy with the R... Ryan Giggs doesn’t believe Manchester United should sack Jose Mourinho despite a poor start to the new Premier League season. The Red Devils were 2-1 winners against Leicester City in their season opener thanks to goals from Paul Pogba and Luke Shaw. However, Manchester United have lost their way... Jose Mourinho retains the full backing of the Manchester United board despite the Red Devils’ stuttering start to the season, according to reports. Sky Sports News is reporting that the Portuguese coach still has the backing of Red Devils chiefs in the wake of Manchester United’s 3-0 loss to Tott... Telegraph.co.uk Ashley Young has been dropped from Gareth Southgate's England squad for the games against Spain and Switzerland, which has opened the door for an international recall for Luke Shaw. Shaw has taken Young's place at left-back for Manchester United and more » As the drama between Paul Pogba and Jose Mourinho continues, Mark Ogden assesses Pogba's role at Manchester United and whose side the fans are on. The English transfer window is closed, but the rest of Europe (except Italy) is still open for business, and Transfer Talk has the latest rumours maki... Telegraph.co.uk As a child, Jack Singleton had little choice but to both play rugby and support Manchester United through the influence of his father, David. He was aged just five when his father enrolled him at Harpenden RFC, the club he coached, the first step in a Telegraph.co.uk Anthony Martial is considering signing a new five-year contract with Manchester United in the latest sign of Jose Mourinho's diminishing power at Old Trafford. Mourinho was keen to offload Martial this summer but any such move was vetoed by Ed Woodward and more » SkySports Gareth Bale has scored in both of Real Madrid's opening La Liga matches. Gareth Bale is capable of replacing Cristiano Ronaldo as the star man at Real Madrid, insists Wales boss Ryan Giggs. Following Ronaldo's £105m move to Juventus, there has been Ander Herrera is confident that Manchester United will be able to return to winning ways in the Premier League when they take on Burnley on Saturday afternoon. The Red Devils slumped to a disappointing 3-0 loss to Tottenham Hotspur in the Premier League at Old Trafford on Monday night to further... Former Man United star rules himself out of being named as next Red Devils boss should Jose Mourinho be sacked The post Former Man United star rules himself out of being named as next Red Devils boss should Jose Mourinho be sacked appeared first on CaughtOffside . SkySports All the top stories and transfer rumours from the back pages of Thursday's national newspapers THE TIMES. Anthony Martial has been offered a new five-year deal at Manchester United and believes he can outlast Jose Mourinho at Old Trafford. and more » Steve Nicol explains the role he thinks Gareth Bale should play in Real Madrid's attack, and Julien Laurens explains how Karim Benzema factors in. Julien Laurens and Ian Darke join the FC panel to answer your latest questions from the twittersphere. Gareth Bale can handle the pressure of having a... Sid Lowe joins the FC panel to address the rumours linking Zinedine Zidane to Manchester United. The English transfer window is closed, but the rest of Europe (except Italy) is still open for business, and Transfer Talk has the latest rumours making the rounds. Follow along with our daily blog th... • Board keen to hold on to previously disaffected player • Move is understood to have José Mourinho’s backing Manchester United are in discussions with Anthony Martial about a new contract, in a move the board are confident has José Mourinho’s backing despite the manager previously being minded t... Ander Herrera has insisted that there are plenty of positives for Manchester United to take from their defeat by Tottenham Hotspur in the Premier League on Monday night. The Red Devils slumped to a 3-0 loss to the Lilywhites in front of their home fans at Old Trafford as they suffered another blo... Great news for Man United: Champions League winner ready to take manager's job if Jose Mourinho is sacked The post Great news for Man United: Champions League winner ready to take manager’s job if Jose Mourinho is sacked appeared first on CaughtOffside . • Young out of England squad to play Spain and Switzerland • Full-back said to understand Gareth Southgate’s decision Ashley Young will be an absentee on Thursday when Gareth Southgate names his first England squad since the run to the World Cup semi-finals, with the manager considering a recall... Man City fearful of losing out to rivals Man United in race for £60M-rated Premier League star The post Man City fearful of losing out to rivals Man United in race for £60M-rated Premier League star appeared first on CaughtOffside . Man United hoping to agree five-year deal with key star that Jose Mourinho doesn't want at Old Trafford The post Man United hoping to agree five-year deal with key star that Jose Mourinho doesn’t want at Old Trafford appeared first on CaughtOffside . Shaka Hislop says the things Jose Mourinho is saying and doing are about separating himself from Manchester United's struggles. The ESPN FC panel talk the parameters that will have to fall into place for Manchester United to entertain the idea of sacking Jose Mourinho. Anthony Martial has not rul... Zinedane Zidane wants Man United to sign Real Madrid trio in January should he take over as manager The post Zinedane Zidane wants Man United to sign Real Madrid trio in January should he take over as manager appeared first on CaughtOffside . SkySports Ryan Giggs is looking forward to working with Paul Dummett after including the Newcastle defender in his latest Wales squad. Watch Next. Giggs: Dummett a boost for Wales · Watch Now · Giggs: Jose is still the right man · Watch Now. Sven: Jose should SkySports Wales forward Hal Robson-Kanu has retired from international football. The announcement was made by Wales manager Ryan Giggs as he named his squad for the matches against Republic of Ireland and Denmark in the UEFA Nations League, live on Sky and more » SkySports Wales manager Ryan Giggs has named Newcastle defender Paul Dummett in his 25-man squad for the upcoming UEFA Nations League games against the Republic of Ireland and Denmark. Dummett has not played for Wales since 2015 and declared and more » SkySports Wales forward Hal Robson-Kanu has retired from international football. The announcement was made by Wales manager Ryan Giggs as he named his squad for the upcoming matches against Republic of Ireland and Denmark in the UEFA Nations League and more » In the aftermath of Manchester United's loss to Tottenham, Craig Burley says it's time for Jose Mourinho, Ed Woodward or both to leave Old Trafford. Jose Mourinho abruptly ends his press conference after Man United's loss to Tottenham, saying he deserves respect for his Premier League success. Jo... The ESPN FC panel talk the parameters that will have to fall into place for Manchester United to entertain the idea of sacking Jose Mourinho. Ryan Giggs has dismissed the prospect of taking over as Manchester United manager if Jose Mourinho is sacked, calling for unity at Old Trafford. United leg... Telegraph.co.uk Jose Mourinho being denied a new centre-back is a crisis of recent provenance, but the ideological void at the heart of his Manchester United tenure has been there from the very beginning. A lack of investment from the Glazers during the late-Ferguson and more » SkySports We're into the final week of the summer transfer window and the back pages are busier than ever. Our friends at Football Whispers have scoured the day's continental press to bring you the best of the transfer news from across Europe. and more » Ander Herrera says it will be "easy" for Manchester United to turn around their poor start of the season if they can recreate the form they showed in the first half against Tottenham Hotspur. Jose Mourinho's side fell to a heavy defeat against Spurs at Old Trafford on Monday night but Herrera has... Who are Harry Kane’s back-ups now the Leicester striker has announced he is stepping down from the national set-up? Marcus Rashford Manchester United Related: Jamie Vardy calls time on England career in talks with Gareth Southgate Related: Jamie Vardy: ‘I’m a nightmare on the pitch – I get abuse... Gerard Pique has admitted that he would love to see Paul Pogba move to FC Barcelona from Manchester United in the future. Pogba’s situation at Old Trafford has been a constant source of speculation in recent months after his failure to produce consistent form for the Red Devils recently. The Fren... ESPN FC's Craig Burley appreciates what Liverpool did in the summer transfer window, but feels Man United were disappointing. Injuries are already putting strain on Burnley's thin squad after just three Premier League games. How can they cope with Europe too? For football supporters of a certain... Gary Neville has sent an apology to Manchester United duo Eric Bailly and Victor Lindelof after being reminded of a horror performance of his own. The Sky Sports pundit was critical of Bailly and Lindelof for their performance in Manchester United’s 3-2 loss to Brighton and Hove Albion at the Ame... Luke Shaw has thanked Manchester United’s “amazing” supporters after Monday night’s 3-0 loss to Tottenham Hotspur at Old Trafford. The Red Devils were looking to make an immediate return to winning ways in the Premier League following a disappointing loss at the Amex Stadium. Manchester United su... The soul of a club is often said to be found in one sacred part of the ground. At Manchester United, it was always the Stretford End, where Jose Mourinho stopped after Monday night's 3-0 defeat by Tottenham Hotspur to enlist the Old Trafford hardcore against his enemies. The relationship between Alex Ferguson and Jose Mourinho has never been as warm as made out, but this is one occasion when the current Manchester United manager could really do with his grand predecessor's wisdom and experience. Gary Neville has urged Manchester United against sacking Jose Mourinho midway through the Premier League season. The Red Devils have already found themselves under pressure in the top flight this season after they slumped to their second straight defeat in the top flight on Monday night. Manchest... Jose Mourinho has insisted that his Manchester United team have a strong spirit despite their 3-0 loss to Tottenham Hotspur in the Premier League on Monday night. The Red Devils were sent crashing to their second straight top flight defeat as they slumped to a home loss to Spurs in front of their... Jose Mourinho singled out Luke Shaw for special praise despite Manchester United’s 3-0 loss to Tottenham Hotspur in the Premier League on Monday night. The 23-year-old England defender played the full 90 minutes at Old Trafford but was unable to prevent his team from slipping to a disappointing l... Jose Mourinho has revealed that Manchester United are waiting to discover the extent of Phil Jones’ injury after the defender was forced off during the 3-0 loss to Tottenham on Monday night. The English defender was hauled off in the 58th minute at Old Trafford after picking up what appeared to b... Luke Shaw has insisted that the mood in the Manchester United dressing room is still good despite successive Premier League losses. The Red Devils were 2-1 winners against Leicester City in their season opener at Old Trafford to secure three points. Manchester United suffered a surprise 3-2 loss... Chris Sutton believes Jose Mourinho has “lost the plot” after Manchester United’s 3-0 loss to Tottenham Hotspur on Monday night. The Red Devils have made a difficult start to the Premier League season following a 3-2 defeat by Brighton and Hove Albion at the Amex Stadium earlier this month. Manch... Harry Redknapp doesn’t believe Manchester United will win the Premier League title this season. The Red Devils have endured a difficult start to the new Premier League season after Jose Mourinho missed out on some key signings in the summer transfer window. Manchester United signed Shakhtar Donet... Luke Shaw was left to rue Manchester United’s failure to capitalise on their ‘outstanding; first-half performance after Monday night’s 3-0 loss to Tottenham Hotspur. The Red Devils were looking to bounce back from a 3-2 loss to Brighton and Hove Albion at the Amex Stadium to lose ground on Chelse... Harry Maguire has insisted that he is happy at Leicester City despite interest from Manchester United in the summer. The England international enjoyed a whirlwind summer after Maguire excelled in Gareth Southgate’s team alongside Manchester City duo Kyle Walker and John Stones. Maguire scored in... Fred is determined to help Manchester United challenge for the top trophies following his move to the club this summer. The Brazilian midfielder is currently getting used to life at Old Trafford after having signed for the Red Devils from Shakhtar Donetsk back in June. The 25-year-old has started... Gary Neville believes that Manchester United should not look to start regularly changing managers as has been the case at Chelsea FC. Jose Mourinho has already found himself under considerable pressure this season after his side slumped to their second straight defeat of the Premier League season... SkySports Back-page headlines and transfer rumours from Wednesday's national newspapers DAILY MAIL. Manchester United's players and staff believe Jose Mourinho could be sacked if he loses again at Burnley on Sunday. and more » SkySports On-loan Manchester United keeper Kieran O'Hara saved three shoot-out spot-kicks as Macclesfield reached the Carabao Cup third round 3-1 on penalties after a thrilling 3-3 draw at Walsall. O'Hara saved from Andy Cook, Luke Leahy and Kieron Morris in the and more » The soul of a club is often said to be found in one sacred part of the ground. At Manchester United, it was always the Stretford End, where Jose Mourinho stopped after Monday night's 3-0 defeat by Tottenham Hotspur to enlist the Old Trafford hardcore against his enemies. The size of the visitors' dressing room at Old Trafford has been almost halved as a result of changes made in an effort to ensure there is no repeat of the tunnel brawl that erupted in December between rival players in the match against Manchester City. The relationship between Alex Ferguson and Jose Mourinho has never been as warm as made out, but this is one occasion when the current Manchester United manager could really do with his grand predecessor's wisdom and experience. The lack of options available to them is the reason as to why Manchester United aren’t going to sack Jose Mourinho, despite him overseeing an awful start to United’s league campaign this season. This is according to the Daily Star, who state that United’s Executive Vice Chairman Ed Woodward still... Jose Mourinho thanked Manchester United’s fans for their “amazing” support after the Red Devils slumped to a 3-0 home defeat by Tottenham Hotspur on Monday night. A goal from Harry Kane and two from Lucas Moura notched up the three points for Mauricio Pochettino’s men as the north London side cla... Jose Mourinho claimed that his Manchester United side were “really unlucky” to lose 3-0 to Tottenham Hotspur in the Premier League at Old Trafford on Monday night. The Red Devils slumped to their second straight defeat of the Premier League season on Monday night as second half goals from Harry K... Luke Shaw reveals what Jose Mourinho said to Man United players at half time during 3-0 Tottenham hammering The post Luke Shaw reveals what Jose Mourinho said to Man United players at half time during 3-0 Tottenham hammering appeared first on CaughtOffside . Telegraph.co.uk Jose Mourinho has the immediate backing of Manchester United, with Ed Woodward, the club's executive vice-chairman, determined to give the manager every opportunity to arrest the team's slump. Woodward has no interest in making any knee-jerk and more » Telegraph.co.uk Manchester United have changed the layout of the home and away dressing rooms at Old Trafford to try to stop any repeat of the tunnel brawl that erupted in December between their players and rivals Manchester City. The changes to the home dressing room and more » Telegraph.co.uk Though he left it late, Jose Mourinho once again dominated the (long) weekend's football headlines - and our comment section - after storming out of a press conference following a 3-0 home defeat at the hands of Spurs on Monday evening. Elsewhere SkySports Manchester United Women endured an underwhelming first home game since relaunching with a 2-0 loss to Reading Women in the League Cup. Brooke Chaplen and Gemma Davison struck as 10-woman Reading condemned United to defeat in the FA Telegraph.co.uk A few years ago, there was a series on Channel 4 called Faking It where contestants have to “fake it” in an alien profession. Vicar to car dealer, showgirl to showjumper, naval officer to drag queen, all that sort of thing. At the end of the episode, a Telegraph.co.uk Manchester United's Monday evening defeat to Tottenham at Old Trafford was Jose Mourinho's heaviest at home in his entire career. Two goals from Lucas Moura and a Harry Kane header led to a tense post-game press conference in which the once-Special and more » Telegraph.co.uk The soul of a club is often said to be found in one sacred part of the ground. At Manchester United, it was always the Stretford End, where Jose Mourinho stopped after the 3-0 defeat to Spurs to enlist the Old Trafford hardcore against his enemies. As and more » SkySports Manchester United's Demetri Mitchell has returned to Hearts on a season-long loan, subject to international clearance. The winger spent the second half of last season at Tynecastle - scoring once in nine appearances - before a knee injury ruled him out and more » Many fans at Old Trafford are blaming the Portuguese for the club’s poor start in the Premier League but Mourinho can turn things around José Mourinho may point to how all three of Tottenham Hotspur’s goals were down to errors in his rearguard and use this as evidence of why he wanted an elite ce... Manchester United have changed the layout of the home and away dressing rooms at Old Trafford to try to stop any repeat of the tunnel brawl that erupted in December between their players and rivals Manchester City. Man United failed with £220M summer transfer bid for world class La Liga superstar The post Man United failed with £220M summer transfer bid for world class La Liga superstar appeared first on CaughtOffside . Telegraph.co.uk In losing 3-0 to Spurs on Monday night, Jose Mourinho suffered his worst ever home defeat in any competition as a manager. The final whistle felt massive. Spurs players celebrated a convincing victory on the pitch while Mourinho went to applaud those and more » Jose Mourinho abruptly ends his press conference after Man United's loss to Tottenham, saying he deserves respect for his Premier League success. Jose Mourinho reacts to Manchester United's 3-0 loss at home against Tottenham, and heaps praise on the fans at Old Trafford. Tottenham took control of... The relationship between Alex Ferguson and Jose Mourinho has never been as warm as made out, but this is one occasion when the current Manchester United manager could really do with his grand predecessor's wisdom and experience. SkySports Barcelona defender Gerard Pique has appeared to rule out ever returning to Manchester United or the Premier League - while praising their rivals. The Spanish centre-back joined United in 2004 having come through Barcelona's youth academy but failed to and more » SkySports European football is back in full flow across the continent, and the transfer windows of Spain, France and Germany remain open until the end of August. Our friends at Football Whispers take you through the biggest stories in the sports pages around Europe. Jose Mourinho abruptly ends his press conference after Man United's loss to Tottenham, saying he deserves respect for his Premier League success. In the aftermath of Manchester United's loss to Tottenham, Craig Burley says it's time for Jose Mourinho, Ed Woodward or both to leave Old Trafford. Jo... Telegraph.co.uk Paul Pogba has admitted it “won't be easy” for Manchester United to bounce back from their miserable start to the season. But the United midfielder said they could not afford to start panicking despite claiming the players were at a loss to explain and more » Telegraph.co.uk He has looked like a man clutching at straws before. Anyone who witnessed his “heritage” rant in the wake of Manchester United's feeble Champions League exit to Sevilla in March will vouch for that. But seldom has Jose Mourinho appeared quite so and more » Telegraph.co.uk Jose Mourinho, the Manchester United manager, was at his typically barbed best, or worst depending on your viewpoint, on Monday night after the Portuguese suffered the biggest home defeat of his career when his side were thrashed 3-0 by Spurs. and more » SkySports Paul Pogba insists Manchester United can bounce back after a 3-0 defeat to Tottenham gave the club their worst start to a Premier League season since 1992. United were humbled on Monday night as Harry Kane's header and Lucas Moura's double gave and more » Telegraph.co.uk Jose Mourinho singled out Luke Shaw for praise in the wake of Manchester United's 3-0 defeat by Tottenham Hotspur and revealed that he told the left back he was now playing at the top of his game. The United manager has endured a stormy relationship and more » Telegraph.co.uk Well that was all a bit weird, wasn't it? On a night of shocks, spills and thrills, Tottenham announced themselves as genuine title contenders with a 3-0 victory over Manchester United to inflict Jose Mourinho's heaviest ever home defeat as a manager. and more » Manchester United have finally got around to revealing their new away kit for the 2018-19 season and it's certainly an eye-catcher. Unveiled the day after United's embarrassing home defeat against Tottenham, the new away shirt is resplendent in dusky pink. Introducing our 18/19 @adidasfootball aw... Jose Mourinho abruptly ends his press conference after Man United's loss to Tottenham, saying he deserves respect for his Premier League success. In the aftermath of Manchester United's loss to Tottenham, Craig Burley says it's time for Jose Mourinho, Ed Woodward or both to leave Old Trafford. So... Jose Mourinho went into Monday night’s game against Tottenham under pressure after Manchester United’s 3-2 defeat to Brighton and that has only intensified following his team’s 3-0 defeat at Old Trafford . The result was emphatic enough but that did not stop the manager from launching a fierce de... Tottenham took control of the second half at Manchester United, burying three goals in the Theatre of Dreams to up the pressure on Jose Mourinho. Jose Mourinho abruptly ends his press conference after Man United's loss to Tottenham, saying he deserves respect for his Premier League success. In th... • Striker believes 3-0 win at Old Trafford is statement of intent • ‘We have to stay up there from the very start’ Harry Kane believes Tottenham Hotspur’s 3-0 win at Manchester United on Monday has laid down a marker regarding their title challenge. The win was Tottenham’s first at Old Trafford u... Jose Mourinho, the Manchester United manager, was at his typically barbed best, or worst depending on your viewpoint, on Monday night after the Portuguese suffered the biggest home defeat of his career when his side were thrashed 3-0 by Spurs. SkySports David Beckham is facing a speeding charge, accused of driving a Bentley over the limit in a 40mph zone. The former Manchester United and England midfielder allegedly drove at 59mph on the A40 at Paddington in west London on January 23. Beckham's and more » Back in 2007/08 Jose Mourinho became the first victim of the Premier League Sack Race after he was ejected from his post at Chelsea. Now, 11 years later, he could well experience the same fate at Manchester United. SkySports Tottenham stun Manchester United at Old Trafford, Jose Mourinho storms out of his press conference and Gary Neville looks at how Wolves caused Man City plenty of problems. Here's all you need to know from Monday Night Football. and more » SkySports Kieran Trippier says Tottenham were lucky to be level at half-time against Manchester United but was pleased with their second-half display. Watch Next. Bolt nervous for Mariners debut · Watch Now · Inside look at Murrayfield Stadium · Watch Now Tottenham took control of the second half at Manchester United, burying three goals in the Theatre of Dreams to up the pressure on Jose Mourinho. Jose Mourinho abruptly ends his press conference after Man United's loss to Tottenham, saying he deserves respect for his Premier League success. In th... Manchester United’s manager seemed keener to make a point than beat Tottenham and may no longer be able to create a team that can attack without being catastrophically open “From a tactical point of view, we didn’t lose, ” said José Mourinho, which must have come as a tremendous relief to the tho... Today’s fluff is demanding contempt, contempt, contempt Seeing as José Mourinho thinks Manchester United didn’t lose “from the strategic point of view and from the tactical point of view” in their 3-0 defeat at the hands of Tottenham Hotspur , it’s probably safe to assume he would also scoff at t... Jamie Redknapp believes Jose Mourinho is edging closer to the end of his Manchester United career. The Red Devils have failed to win the Premier League title since Sir Alex Ferguson stood down as manager at Manchester United at the end of the 2012-13 season. Mourinho won the Europa League and the... Mauricio Pochettino has lavished praise on Jose Mourinho, insisting that the Portuguese coach has been an inspirational figure for him. The Manchester United boss has cut a frustrated figure at Old Trafford in recent months after the Red Devils ended up in second place in the Premier League table... Not quite what you'd expect to see after Brazilian led 3-0 win over United The post Video: Man Utd fans SLAMMED, caught taking SELFIES with Lucas Moura after Tottenham defeat appeared first on CaughtOffside . SkySports The draw for the Champions League group stage takes place in Monaco on Thursday with four Premier League teams set to discover their fate. Manchester City, Manchester United, Tottenham and Liverpool all go straight in at the group phase courtesy of and more » Telegraph.co.uk When things get really bad in his career and events spiral out of control, Jose Mourinho can never stop himself defending the one thing that matters more to him than anything in football - that being his own reputation and the achievements he has and more » Jamie Redknapp has admitted that he is concerned about Manchester United’s lack of fight under Jose Mourinho. The Red Devils suffered their first Premier League defeat of the 2018-19 season earlier this month following a 3-2 loss to Brighton and Hove Albion at the Amex Stadium. Manchester United... Jamie Redknapp has warned Jose Mourinho that the “writing is on the wall” at Manchester United. The Red Devils have failed to win the Premier League title since Sir Alex Ferguson stood down as manager at the end of the 2012-13 season. The Scottish legend won the Premier League crown in his final... Tottenham stun Manchester United at Old Trafford, Jose Mourinho storms out of his press conference and Gary Neville looks at how Wolves caused Man City plenty of problems. Here's all you need to know from Monday Night Football Wayne Rooney has insisted that Manchester United have what it takes to win the Premier League title this season. The Red Devils have just started their third season under Jose Mourinho as they look to build on their disappointing trophyless campaign last term. Manchester United finished in second... SkySports David Jones is joined by Jamie Carragher and Gary Neville to analyse the big talking points from Monday Night Football. Jose Mourinho walked out of the post-match news conference demanding more "respect" after Lucas Moura scored twice in Tottenham's and more » Telegraph.co.uk Jose Mourinho was showing growing signs of strain on Monday night as the embattled Manchester United manager launched a desperate defence of his managerial record after suffering the heaviest home defeat of his career. Mourinho walked out of his and more » Telegraph.co.uk It is worth remembering that Mauricio Pochettino did not get what he wanted in the transfer market this summer either yet, unlike his Manchester United counterpart Jose Mourinho, you will not find the Tottenham Hotspur manager crying over what might or and more » Manchester United manager José Mourinho walked out of a post-match press conference after Monday’s 3-0 defeat to Tottenham while demanding more ‘respect’. A visibly riled Mourinho reminded journalists he has won more Premier League titles alone than the other 19 current managers combined. Continu... SkySports Romelu Lukaku missed an open goal on what proved to be a night to forget for Manchester United against Tottenham in the Premier League. With the scores still at 0-0 in the 16th minute, the Belgium international latched onto Danny Rose's sloppy back and more » SkySports Jose Mourinho insists his tactics did not cause Manchester United to lose 3-0 against Tottenham on Monday Night Football, and says the whole team is fully united. Goals from Lucas Moura (2) and Harry Kane gave Spurs all three points at Old Trafford, and more » Telegraph.co.uk David De Gea. One solid save in the first half to keep out Eriksen shot and another to stop Kane shot in the second. No chance with either of the two goals but prevented Alli scoring a third 6. Antonio Valencia. Solid in defence but less impressive in and more » SkySports Speaking on Monday Night Football following Manchester United's 3-0 defeat to Tottenham at Old Trafford, Gary Neville explains why Jose Mourinho is now facing the biggest challenge of his career I hated the Brighton performance. There was nothing to and more » SkySports Mauricio Pochettino is urging Tottenham supporters to stay calm after their 3-0 win at Old Trafford, but hopes the 'massive victory' will give his side a confidence boost. Watch Next. Pochettino: Win a 'massive victory'. Pochettino: Win a 'massive victory. In the aftermath of Manchester United's loss to Tottenham, Craig Burley says it's time for Jose Mourinho, Ed Woodward or both to leave Old Trafford. Mauricio Pochettino says he never considered stripping Hugo Lloris of the captaincy after his arrest for drink driving. Lloris is due to appear at W... Anthony Martial was reportedly baffled to be dropped by Manchester United for the Monday night defeat against Tottenham. According to RMC, the France international found it ‘incomprehensible’ that he didn’t play a part in the game as he was not injured for the visit of Spurs to Old Trafford. MORE... MANCHESTER, England -- Jose Mourinho held up three fingers at the end of a stormy press conference following Manchester United's 3-0 defeat against Tottenham at Old Trafford. The former Chelsea and Real Madrid coach was attempting to make the point that he had "won more Premiership titles than t... Former Manchester United stalwart Gary Neville believes that Mourinho is facing the ‘biggest challenge’ of his entire career after losing to Spurs. Old Trafford has played host to many glorious games and victories for United over the years but rarely has it been the venue for such an earth-shatte... • Manchester United manager close to meltdown after 3-0 defeat • Mourinho admits he does not know his best defence An angry Jose Mourinho demanded “respect, respect, respect” for his three Premier League titles following Manchester United’s 3-0 defeat. He had been talking up United’s display, cla... Tottenham took control of the second half at Manchester United, burying three goals in the Theatre of Dreams to up the pressure on Jose Mourinho. In the aftermath of Manchester United's loss to Tottenham, Craig Burley says it's time for Jose Mourinho, Ed Woodward or both to leave Old Trafford. Jo... Gary Neville is adamant Manchester United should not consider sacking Jose Mourinho until the end of the season at the earliest. Monday night's 3-0 defeat at home to Tottenham came on the back of last weekend's 3-2 loss at Brighton as the club suffered and more » Man United’s 3-0 defeat to Tottenham will no doubt spark fresh debate over the future of Mourinho, but how much would the club lose if he were to be fired? The Portuguese boss hit an all-time low tonight after the Red Devils slumped to successive Premier League defeats, as the unrest surrounding... Harry Kane praises his side for making amends for their poor first-half display and for the tempo they maintained against Manchester United. Tottenham took control of the second half at Manchester United, burying three goals in the Theatre of Dreams to up the pressure on Jose Mourinho. Jose Mouri... It’s not a good night to be a Manchester United fan as some on Twitter are actually begging their club to sack Jose Mourinho and bring in Zinedine Zidane. CaughtOffside understands Zidane has communicated that he is confident he could be offered the chance to replace Mourinho imminently, accordin... Manchester United were disjointed against Spurs after six changes and the manager looks no nearer to ending the uncertainty As half-time approached there was a moment that encapsulated the ongoing frustrations of José Mourinho. When Antonio Valencia won a throw-in near halfway Manchester United’s... Manchester United boss Jose Mourinho made an angry exit from tonight’s press conference after his team’s 3-0 defeat against Spurs at Old Trafford. The Portuguese boss watched on from the sidelines in horror tonight as his team slumped to a shocking loss at Old Trafford, which sees them fall six p... Tottenham took control of the second half at Manchester United, burying three goals in the Theatre of Dreams to up the pressure on Jose Mourinho. Three second-half goals gave Mauricio Pochettino his first win as manager at Old Trafford and Tottenham their biggest win away to Manchester United in... Jose Mourinho reacts to Manchester United's 3-0 loss at home against Tottenham, and heaps praise on the fans at Old Trafford. Tottenham took control of the second half at Manchester United, burying three goals in the Theatre of Dreams to up the pressure on Jose Mourinho. MANCHESTER, England -- Jo... SkySports Ahead of a huge clash between Man Utd and Tottenham on Monday Night Football, Jamie Carragher and Gary Neville give their lowdown on the tactics they expect to see at Old Trafford. Watch Next. Nev and Carra's MNF tactical preview · Watch Now Liverpool legend and Sky Sports pundit Jamie Carragher highlighted Manchester United defender Victor Lindelof as being out of depth at this level. The Sweden international did not start tonight’s game against Tottenham but came on off the bench at Old Trafford and has had more of a key role so fa... Manchester United boss Jose Mourinho has fired an insult at the rest of his managerial colleagues in the Premier League after tonight’s defeat to Spurs. The Red Devils slumped to a 3-0 loss at Old Trafford tonight after Mauricio Pochettino’s side ran riot in the second half, with Harry Kane scori... Jose Mourinho reacts to Manchester United's 3-0 loss at home against Tottenham, and heaps praise on the fans at Old Trafford. Tottenham took control of the second half at Manchester United, burying three goals in the Theatre of Dreams to up the pressure on Jose Mourinho. Jose Mourinho stood by hi... Manchester United legend Gary Neville criticised Romelu Lukaku for missing a great chance in the first half against Tottenham in tonight’s Premier League defeat. Neville, speaking on punditry duty for Sky Sports, conceded it was a slightly harder chance than it looked due to being on his weaker f... Tottenham boss Mauricio Pochettino was dressed in all black attire for tonight’s game against Manchester United, which fans have alluded to after the game. Spurs inflicted a second straight defeat on Mourinho’s side tonight at Old Trafford, winning 3-0 thanks to two goals from Lucas Moura and a H... Tottenham took control of the second half at Manchester United, burying three goals in the Theatre of Dreams to up the pressure on Jose Mourinho. English Premier League: Lucas Moura (84') Manchester United 0-3 Tottenham English Premier League: Lucas Moura (52') Manchester United 0-2 Tottenham Eng... Manchester United have conceded seven goals in their first three league games of the season for the first time in 49 years. This remarkable stat from journalist Andy Mitten in the tweet below just sums up how bad the Red Devils have been so far this season. MORE: Video: Jose Mourinho’s intriguing... Tottenham took control of the second half at Manchester United, burying three goals in the Theatre of Dreams to up the pressure on Jose Mourinho. English Premier League: Lucas Moura (84') Manchester United 0-3 Tottenham English Premier League: Lucas Moura (52') Manchester United 0-2 Tottenham Eng... Jose Mourinho took a long moment to applaud the Manchester United home fans after today’s 3-0 defeat to Tottenham at Old Trafford. The Red Devils were well beaten by Spurs in another poor performance, making it two defeats from three games already this season – their worst record at this stage of... If nothing else, there was no mutiny. José Mourinho still heard his name being sung and, at the final whistle, Old Trafford was not too unkind on the manager or his players. Yet these are deeply troubling times for Manchester United, with the chants of “you’re not special any more” loud and clear... Manchester United have lost two from their first three opening Premier League games for the first time in 26 years. Goals from Harry Kane and two from Lucas Moura gave Tottenham a superb 3-0 win away to United this evening in a stunning result to pile the pressure onto Jose Mourinho. Not since th... Tottenham winger Lucas Moura has surely put tonight’s game against Manchester United to bed with a stunning solo goal late on. It’s now 3-0 to Spurs at the time of writing as Mauricio Pochettino’s men run away with it at Old Trafford and pile more misery onto Red Devils manager Jose Mourinho. MOR... Former Manchester United defender Gary Neville was pleasantly surprised by the Red Devils first-half display against Tottenham at Old Trafford. The two teams have been going toe to toe on tonight’s edition of Monday Night Football on Sky Sports, with the score currently in Tottenham’s favour at 2... Tottenham scored two goals in as many minutes through Harry Kane and Lucas Moura to stun Manchester United at Old Trafford. First, Kane headed home his first ever goal at Old Trafford, and moments later a superb flowing move saw Lucas finish off from Christian Eriksen’s ball into the box. MORE: ‘... Some Manchester United fans are calling on the club to sell Paul Pogba to Barcelona after a poor performance against Tottenham tonight. It’s half time at the time of writing, with the score level at 0-0 at Old Trafford as Pogba looks a shadow of his former self once again in a United shirt. MORE:... Manchester United midfielder Fred was seen bizarrely with his hands behind his back around the halfway line when closing down Tottenham right-back Kieran Trippier. We know the Brazil international is still getting used to the physicality of the English game here in the Premier League, but this is... Lucas Moura gets off lightly with a yellow card after a dangerous challenge on Phil Jones against Manchester United on Monday night. In what has been a highly charged opening to tonight’s Premier League clash between Man United and Spurs, the latter will consider themselves lucky to still have 11... Romelu Lukaku missed an absolute sitter for Manchester United in their Premier League clash with Tottenham this evening. The Belgium international was put through by a misplaced Danny Rose back-pass, before bizarrely missing a gaping goal when he rounded Hugo Lloris. MORE: Jose Mourinho contacts... The Tottenham captain, named in the starting line-up against Manchester United, was arrested and charged with drink driving. Mauricio Pochettino said the situation is still 'painful' for his goalkeeper. Manchester United and Tottenham lock horns in the Premier League tonight, with Jose Mourinho naming a conservative line-up for the clash. The Red Devils come into this match off the back off a disappointing away defeat to Brighton last time out, whilst Spurs arrive at Old Trafford having won thei... Tottenham manager Mauricio Pochettino is on the receiving end of a fair amount of abuse on Twitter tonight after starting Hugo Lloris as his captain against Manchester United. Many fans are not at all impressed that the Spurs goalkeeper has retained his place and the armband after being charged f... SkySports England centre-back Harry Maguire will only get better, according to the manager who signed him for Leicester in 2017. Manchester United had two summer bids rejected for the 25-year-old defender, with the second offer understood to be £60m. That would and more » Updates from the 8pm BST kick-off at Old Trafford Email Jacob or tweet @JacobSteinberg Mourinho v Pochettino is a clash of outlooks 6.25pm BST Hello. Given Tottenham’s miserable record at Old Trafford in recent years, it hasn’t quite reached the point where Mauricio Pochettino can enter the away... Manchester United manager Jose Mourinho has reportedly personally got in touch with the entourage of Real Madrid defender Raphael Varane to discuss a transfer. The France international looks to be surprisingly out of favour at the Bernabeu at the moment, following the arrival of Julen Lopetegui a... SkySports Tottenham manager Mauricio Pochettino sees Jose Mourinho as one of the most inspirational managers of his generation, but insists he's not intimidated by him. Watch Next. Pochettino: Jose's an inspiration · Watch Now · McLeish: It's a new era for Scotland. As the drama between Paul Pogba and Jose Mourinho continues, Mark Ogden assesses Pogba's role at Manchester United and whose side the fans are on. Alejandro Moreno and Shaka Hislop delve into Man United's performance against Brighton and Paul Pogba's post-match comments regarding his attitude. Sh... Paul Pogba has endured a tough start to the season at Manchester United, his relationship with boss Jose Mourinho under constant scrutiny. the circumstances mean talk of a departure are not so far-fetched. Manchester United manager Jose Mourinho is reportedly prepared to bring in Nemanja Matic as part of a back three and seemingly drop Eric Bailly for the Tottenham game tonight. The Red Devils lost 3-2 to Brighton in their last game as they looked hugely unconvincing at the back, with Mourinho now... SkySports Jose Mourinho says he pays no attention to media reports of problems at Manchester United and insists he remains calm. Watch Next. 'Maguire will get better' · Watch Now · Pochettino: Jose's an inspiration · Watch Now · Hughton: PL so competitive. Jose Mourinho will shake hands with the manager tipped to succeed him as Manchester United manager on Monday night and the Old Trafford landscape may be shifting at the perfect moment for Spurs boss Mauricio Pochettinho to inherit his throne. SkySports Kaku's goal was enough for New York Red Bulls to defeat D.C. United 1-0 at the Red Bull Arena, with Wayne Rooney striking the bar. Kaku scored his fourth goal after a clearance by D.C.'s Kofi Opare landed at his feet. Kaku feigned a shot, dribbled left and more » Telegraph.co.uk It's the Premier League meeting between Manchester United and Tottenham Hotspur. When is it? Tonight. So that's Monday Aug 27, 2018. What time is kick-off? Referee Craig Pawson will get the match at Old Trafford under way at 8pm (BST). What TV and more » Telegraph.co.uk 'The Missing Centre-back', a thriller starring Jose Mourinho and Harry Maguire, will feature in much of the pre-match buildup for Man Utd vs Spurs on Monday night, but what about Mauricio Pochettino's lack of summer business? Can't coaches get their and more » Stewart Robson shares his thoughts on both Manchester United's and Tottenham's strengths and weaknesses and where he feels the game can be won. The FC crew respond to your tweets about Jose Mourinho, Max Allegri, the Premier League Golden Glove and Liverpool's centre-backs. Steve Nicol praises Jo... SkySports We take a look at some of the most memorable goals over the years between Tottenham and Man United, ahead of their Monday Night Football clash. Watch Next. Man United v Tottenham - Memorable goals · Watch Now · Newcastle 1-2 Chelsea SkySports European football is back up and running, but the transfer windows of Spain, France and Germany are still very much open. Our friends at Football Whispers take you through the biggest stories in the sports pages of Europe. Italy and more » SkySports Ahead of Manchester United v Spurs, Jamie Redknapp assesses the problems at Old Trafford and the relationship between Jose Mourinho, his players and the board Tottenham have an awful record against big-six sides away from home - but they will be and more » SkySports Manchester United and Tottenham meet for the 53rd time in the Premier League on Monday Night Football, but what has been the greatest game between the two? Spurs' first win against United in the Premier League came in January 1996 when they won and more » Stewart Robson shares his thoughts on both Manchester United's and Tottenham's strengths and weaknesses and where he feels the game can be won. Mauricio Pochettino challenges his Tottenham side to end their poor run of results at the home of Manchester United. Ian Darke joins the FC panel to prev... When a manager has used media performances as much as Jose Mourinho, and works at a club where public image has become as commercially important as winning titles, it is only natural that those performances will come in for almost as much analysis as his team’s actual games. Chris Sutton believes Manchester United should prioritise keeping Paul Pogba over Jose Mourinho. The Reds Devils are verging on a crisis following a disappointing start to the Premier League season. Manchester United were 2-1 winners against Leicester City in their season opener to make a promisi... SkySports It's Tottenham with the momentum ahead of their Monday Night Football clash at Manchester United - but they'll have to overcome a terrible record at Old Trafford to win three in a row. Spurs have seen off Newcastle and Fulham in their Premier League and more » Martin Keown has urged Manchester United star Paul Pogba to tell his agent to shut up. The Red Devils signed Pogba in an £89m deal from Serie A giants Juventus in the 2016 summer transfer window. Manchester United made the France international their record signing having sold the Red Devils to Ju... Kevin Kilbane has pinpointed why Eric Bailly has struggled at Manchester United. Jose Mourinho made the Ivory Coast international his first Manchester United signing in the 2016 summer transfer window. The Ivorian defender made a strong start to his Manchester United career before Bailly struggle... Jose Mourinho believes that Fred is already having a positive impact since his move to Manchester United in the summer transfer window. The Brazilian midfielder has been settling into life at Old Trafford after having signed for the Red Devils in the summer transfer window as Mourinho moved quick... SkySports Mauricio Pochettino has called on Tottenham to end their Old Trafford hoodoo on Monday Night Football and in the process lay down a marker for the rest of the season. Spurs have lost more matches at the 'Theatre of Dreams' than any side in Premier and more » Victor Lindelof isn’t good enough to play for Manchester United, Kevin Kilbane has claimed. The Red Devils suffered a surprise 3-2 loss to Brighton and Hove Albion at the Amex Stadium on Sunday evening. Romelu Lukaku and Paul Pogba got on the score sheet but the Red Devils produced a disappointin... Chris Sutton has ruled out Manchester United challenging for the Premier League title this season. The Red Devils suffered a surprise 3-2 loss to Brighton and Hove Albion at the Amex Stadium on Sunday evening. Manchester United’s defeat means the Red Devils have already lost ground on Manchester... Martin Keown has urged Paul Pogba to stop trying so hard at Manchester United. The France international has failed to rekindle his Juventus form since his move back to Manchester United in an £89m deal. Pogba won the Europa League and the League Cup in their first season back at Old Trafford unde... Manchester United will look to revive their bid to sign Lorenzo Pellegrini from AS Roma in the January transfer window, according to reports in the British media. The Sun is reporting that the Red Devils could be set to make a fresh bid to try and land the midfielder in the mid-season transfer wi... Telegraph.co.uk Jose Mourinho has insisted he always puts his club's needs before his own as he challenged his Manchester United players to repay the faith of the fans against Tottenham Hotspur at Old Trafford on Monday. The United manager is hoping supporters can and more » SkySports Leicester defender Harry Maguire respects the club's decision to block a summer transfer to Manchester United. United had two bids rejected for the England centre-back, with the second offer understood to be £60m. Maguire expected media speculation and more » Wayne Rooney has told Paul Pogba that he is the only person responsible for stepping his game up at Manchester United. The French midfielder has come under criticism for failing to produce consistent displays for the Red Devils in recent months and his below-par display contributed to Manchester...
Q: How would you use the cpio command? While studying for the lpic exam, I've run into the command cpio. The description of cpio states: Cpio was originally designed to store backup file archives on a tape device in a sequential, contiguous manner. Cpio does not compress any content, but resulting archives are often compressed using gzip or other external compressors. In looking at examples of how to use cpio, I can't find a single scenario where cpio would better than more common tools like tar. What is an example where using cpio would be used, (besides tape backups), or is it no longer relevant on todays systems? A: It is still relevant for unpacking RPMs. There is a rpm2cpio utility that converts an RPM package to a cpio archive. As far as I know, there is nothing to convert an RPM to a tar archive. Here is an example usage: rpm2cpio myrpmfile.rpm | cpio -idmv
/** * WordPress dependencies */ import { memo } from '@wordpress/element'; /** * Internal dependencies */ import { BackdropUI } from './styles/input-control-styles'; function Backdrop( { disabled = false, isFocused = false } ) { return ( <BackdropUI aria-hidden="true" className="components-input-control__backdrop" disabled={ disabled } isFocused={ isFocused } /> ); } const MemoizedBackdrop = memo( Backdrop ); export default MemoizedBackdrop;
import datadog.trace.api.Trace; import java.util.concurrent.Callable; import java.util.concurrent.atomic.AtomicBoolean; import scala.concurrent.forkjoin.ForkJoinTask; public class ScalaAsyncChild extends ForkJoinTask implements Runnable, Callable { private final AtomicBoolean blockThread; private final boolean doTraceableWork; public ScalaAsyncChild() { this(true, false); } @Override public Object getRawResult() { return null; } @Override protected void setRawResult(final Object value) {} @Override protected boolean exec() { runImpl(); return true; } public ScalaAsyncChild(final boolean doTraceableWork, final boolean blockThread) { this.doTraceableWork = doTraceableWork; this.blockThread = new AtomicBoolean(blockThread); } public void unblock() { blockThread.set(false); } @Override public void run() { runImpl(); } @Override public Object call() throws Exception { runImpl(); return null; } private void runImpl() { while (blockThread.get()) { // busy-wait to block thread } if (doTraceableWork) { asyncChild(); } } @Trace(operationName = "asyncChild", resourceName = "asyncChild") private void asyncChild() {} }
1. Technical Field This disclosure generally relates to airflow sensors, and more specifically relates to an airflow sensor for a heat sink. 2. Background Art Heat sinks are commonly used in modern electronic systems to dissipate heat generated by electronic components, such as processors. A source of air such as a fan is typically placed in proximity to a heat sink to produce airflow over the heat sink, which enhances the ability of the heat sink to dissipate heat. Modern heat sinks are typically modeled using thermal simulation. Prototypes are then built, which are qualified with thermal test vehicles and flow benches. However, even with thermal simulation and flow bench qualification, a heat sink may behave differently in a system than modeled. Oftentimes the internal environment is difficult to predict and model.
India is reportedly rethinking its decision of Union minister Sushma Swaraj meeting her Pakistani counterpart Shah Mahmood Qureshi. India on Friday called off the meeting between external affairs minister Sushma Swaraj and her Pakistani counterpart Shah Mahmood Qureshi that was scheduled to take place on the sidelines of the United Nations General Assembly (UNGA). Ministry of External Affairs (MEA) spokesperson Raveesh Kumar said that since Thursday's announcement when India confirmed the talks, two extremely disturbing developments have taken place. "The latest brutal killings of our security personnel by Pakistan-based entities and the recent release of a series of 20 postage stamps by Pakistan glorifying a terrorist and terrorism confirm that Pakistan will not mend its ways," Kumar said. Since y'day's announcement of meeting of foreign ministers of India & Pakistan, 2 deeply disturbing developments took place. Latest brutal killings of our security personnel by Pakistan entities & recent release of series of 20 postal stamps by Pakistan glorifying terrorists: MEA pic.twitter.com/5rTVKmOxEn — ANI (@ANI) September 21, 2018 India is upset over the killing of Jammu and Kashmir policemen. Three Jammu and Kashmir policemen, who were abducted in Shopian district on Thursday night, were killed by Hizbul Mujahideen terrorists. Militants had kidnapped the three Special Police Officers (SPOs) and one police personnel after barging into their houses on Thursday. India is also upset over Pakistan's decision to declare slain Hizbul Mujahideen commander Burhan Wani as a "freedom icon". Pakistan also commemorated the "victims of atrocities by Indian troops in Kashmir" by issuing 20 special postage stamps which carry captions such as: 'Burhan Wani (1994-2016) freedom icon'. The stamps carry photos of Wani and his two associates who were killed in a gunbattle with police in the Anantnag district of Jammu and Kashmir in July 2016. Kumar also said, "It's obvious behind Pakistan's proposal for talks to make a fresh beginning, evil agenda of Pakistan stands exposed and the true face of new Prime Minister of Pakistan has been revealed to world in his first few months in office." #WATCH: MEA spokesperson Raveesh Kumar says, "It's obvious that behind Pakistan's proposal for talks to make a fresh beginning, evil agenda of Pakistan stands exposed & true face of new Prime Minister of Pakistan has been revealed to world in his first few months in the office" pic.twitter.com/e25STpUlTh — ANI (@ANI) September 21, 2018 On Thursday, Kumar had said Swaraj will meet Qureshi on the sidelines of UNGA, but the date will be decided later through consultations. He also said that the meeting did not imply a resumption of talks between India and Pakistan, while adding, "This meeting is taking place on the request of the Pakistani side. We have not finalised the agenda of this meeting."
"Not fit to be called people; they are a cancer." Strong words came from Israeli Industry, Trade, and Labor Minister Eli Yishai, as reported in the Jerusalem Post today. Yishai was referring to eight Israeli neo-Nazis who were recently arrested, each of whom were granted favorable immigration status under the Law of Return. All eight were admitted from the former Soviet Union. The Law of Return provides that immigrants can receive Israeli citizenship if they can claim one Jewish grandparent. They need not be Jewish themselves to benefit from favorable immigration status. The arrests have set off debates throughout the country about amending the Law of Return. Claims of discrimination against immigrants from the former Soviet states are also being traded. Finally, Drew can add these fellows to his Dumb Criminal Round Up; they videotaped their crimes, which include assaulting Orthodox Jews in the street, vandalizing synagogues, and attacking people they thought were punks, gays, or (ironically) foreigners.
Zhirinovsky announces plans to run for presidency in 2018 September 21, 2013, 22:50 UTC+3Russian Liberal Democratic Party leader said he would run for the office of president until 2036 Share 1 pages in this article Photo ITAR-TASS /Sergei Fadeichev MOSCOW, September 21 (Itar-Tass) - Russian Liberal Democratic Party leader Vladimir Zhirinovsky said he would run for the office of president until 2036. Zhirinovsky has contended for presidency five times before. “I will do it for the sixth time in 2018 and again for the seventh time in 2024,” he told the Central Television programme on Saturday, September 21. The politician noted that he would turn 71 by the time the nearest presidential election is held in 2018. “In 2036, I will be 90. This will be my last election. I want to stay by my voters,” Zhirinvosky said.
/* * FILE: win32ss/napi.h * COPYRIGHT: GNU GPL, see COPYING in the top level directory * PURPOSE: System Call Table for Native API * PROGRAMMER: Timo Kreuzer */ #define SVC_(name, argcount) (ULONG_PTR)Nt##name, ULONG_PTR Win32kSSDT[] = { #include "w32ksvc.h" }; #undef SVC_ #define SVC_(name, argcount) argcount * sizeof(void *), UCHAR Win32kSSPT[] = { #include "w32ksvc.h" }; #define MIN_SYSCALL_NUMBER 0x1000 #define NUMBER_OF_SYSCALLS (sizeof(Win32kSSPT) / sizeof(Win32kSSPT[0])) #define MAX_SYSCALL_NUMBER 0x1000 + (NUMBER_OF_SYSCALLS - 1) ULONG Win32kNumberOfSysCalls = NUMBER_OF_SYSCALLS;
US to Hand over Control of DNS to ICANN United States has finally decided to hand over the critical part of the internet’s governance by handing over one of its most important component, the DNS. The shock and disbelief that had hit internet users with news that the USA is ceding one of the internet’s most famous units, DNS or Domain Naming System, to ICANN, is slowly subsiding with new revelations that ICANN has indeed been controlling the DNS for years. And that the change will barely be noticed. The Internet Corporation for Assigned Names and Numbers, unknown to many internet users, is a non-profit organization based in the US. An affiliate called Public Technical Identifiers (PTI) had been formed to handle the handover technicalities, by the California Secretary of State. This confirmation of the transferDNS to ICANN brings to an end a twenty-year process involving the internet’s vital component, DNS. DNS (Domain Naming System) Primarily, DNS generates and pairs web addresses, like CNN.com with their source servers, making them easy to remember. Without DNS, you can only reach a website by typing in a series of numbers, like “543.764.986” This is called an IP address. It’s not clear why the US has always retained the ultimate control and say over DNS, but now it appears to be satisfied with the decision and has complete confidence for ICANN to take over the DNS control. But there have been fears that relaxing control will only open doors for Russia and China to infiltrate an already vulnerable system. Republicans are particularly incensed. In a letter released after the news broke out, they warned, “The proposal will significantly increase the power of foreign governments over the internet.” US will hand over DNS supervision to ICANN ICANN, which operates under license from the US Department of Commerce, runs the Internet Assigned Numbers Authority, (IANA), which is responsible for the DNS root, protocol resources, and the IP address. In March 2014, the National Telecommunications and Information Administration, (NTIA) which operates within the Department of Commerce, had signaled its intention to terminate its contract with ICANN by September 2015, hence passing control of the agency to a global-like authority. The Commerce Department has explained that the brief delay in transition was occasioned by the need to give the internet multi-stakeholder groups, sufficient time to develop a transition plan, which would convince critics that Internet control was not being handed over to the governments. The underlying fear was that some states are known to stifle online activity and heavy-handed censorship. The new PTI, which is a fully fledged legal entity, is not mandated to perform any services in lieu of the IANA contract under NTIA, but will commence conducting those functions once the arrangement with ICANN has been finalized. Created in 1998, by Jon Postel, ICANN has dominated the assigning of web addresses, and critics are divided whether fears by a foreign infiltration are justified. Known to many as “god of the internet,” he pioneered many research breakthroughs and was at the forefront of systems that support networking today. Mr. Postel singlehandedly drove the Internet Assigned Numbers Authority, (IANA), but the final say in administration, was still under the iron grip if the NTIA. And it’s this iron grip that’s being relaxed come October 2016. The NTIA will no longer intervene in the Internet’s DNS. It’s not like the NTIA had an ugly head; indeed it rarely interfered. A case in point is when it halted ICANN’s attempt to launch a luxury pornography domain ending, “. Xxx.” The authorities wanted ICANN to dump the idea, but it proceeded anyway. Pundits are terming the move (DNS transfer) a “breath of fresh air” in that it marks a change from a cyberspace controlled by one country to one governed by many, giving others say to what has evolved as a global asset, embraced by many cultures. It was easy for the US to retain control of DNS but it has sensed the need to heighten diplomacy around the world by relinquishing a primary tool that makes communication not only easy and enjoyable but also an avenue to promote world peace. This gesture by the US could be a wake-up call to other countries with deplorable human rights records to relax their iron grip on their citizen’s freedom of expression and allow more tolerance. Previously China and Russia wanted the DNS to be controlled by the United Nations. A treaty they collectively sponsored in 2012, was defeated by the US, Canada, the UK and Australia, when they cited human rights abuses that would arise if other countries were given access to the basics of the internet. The good news is that the average web user will hardly notice the action by NTIA and will continue using the internet much like before. The transfer of control of DNS to ICANN will not affect the activities of the internet. Disclaimer: This website and its content (including links to other websites) are presented in general form and are provided for informational purposes only. Please seek legal advice for all topics you wish to follow on with.
2. Tease your hair. Section the hair on the top of your head in the shape of a U from temple to temple, and then backcomb the entire U formation, creating mod-like volume. 3. Add texture to your hair. Apply a little bit of pomade to your hands, and rake your fingers through the length of your strands to give them more texture and grip. This will prevent your hair from slipping out of the ponytails. 4. Create a half-ponytail. Smooth over the teased hair on top, and pull it back into a half-ponytail. Secure the hair with an elastic, then take a small strand from the bottom of the ponytail, and wrap it around the base to conceal the elastic. Pin it into place with a bobby pin. 5. Add another ponytail a few inches below the first. Grab the section of hair in the middle of your head, and combine it with the teased top ponytail. Secure the new, combined ponytail, and wrap a small strand of hair around the base to conceal the elastic like before. Gently tug on the strands in between the elastics to give the sections extra pouf. Then make the third pony at the nape of your neck by grabbing all the rest of your loose hair and combining it with the first two ponys. Secure it, and conceal the elastic. 6. Tease the lower sections before securing them for extra volume. As the end of your ponytail begins to thin, add some more volume by teasing the hair below the elastics before securing the next section. Depending on the length of your hair, each elastic should be 2-3 inches apart. Continue teasing and tying off the sections until you've reached the end. You're finished! Now go Instagram the hell out of your pretty, voluminous pony, and tweet @Cosmopolitan with the hashtag #Cosmosexyhair.
Q: Is there a regular expression in Perl to find a file's extension? Is there a regular expression in Perl to find a file's extension? For example, if I have "test.exe", how would I get the ".exe"? A: my $file = "test.exe"; # Match a dot, followed by any number of non-dots until the # end of the line. my ($ext) = $file =~ /(\.[^.]+)$/; print "$ext\n"; A: use File::Basename use File::Basename; ($name,$path,$suffix) = fileparse("test.exe.bat",qr"\..[^.]*$"); print $suffix; A: \.[^\.]*$ This would give you everything after the last dot (including the dot itself) until the end of the string.
SANTA CLARA, Calif. -- As Colorado's Jimmie Gilbert dragged Jake Browning to the turf in the third quarter of Friday's Pac-12 championship game, the Washington quarterback -- already playing one of his worst games of the season -- heaved what any coach might deem his worst throw of the night. It was an interception waiting to happen, a wobbler that floated toward the flat in what seemed like slow motion. Chidobe Awuzie, the Buffaloes' star cornerback, had a bead on it. But receiver John Ross -- like an outfielder robbing a home run -- soared into the air, stretched his right arm up high and snatched the ball with one hand. As Ross bolted free toward the end zone seconds later, this much was clear: These Huskies can electrify, even when it's not pretty. Washington spanked Colorado 41-10 to win the Pac-12 championship and remain a favorite to qualify for the College Football Playoff. Taylor Rapp returned the first of his two interceptions for the second-half touchdown that opened the floodgates for Washington on Friday. Robert Reiners/Getty Images Facing a Colorado secondary that entered the game leading the nation in key categories, Browning completed 9 of 24 passes for 118 yards, a measly average of 4.9 yards per attempt. This was a far cry from Washington's 11 victories during the regular season, in which Browning emerged as a national standard of efficiency. But those struggles didn't matter: The Huskies proved they're a complete team, one that can win a championship game in blowout fashion even with its signature aerial attack grounded. Myles Gaskin (159 yards) and Lavon Coleman (101 yards) became the first two teammates to surpass 100 rushing yards in Pac-12 championship game history. Even as the Buffs' secondary suffocated Washington's passing in the first half, the Huskies' dynamic running backs barreled forward for better than 6 yards per carry to put their team in control of the game. Then the Washington defense clamped down. Much has been written about the Huskies' key losses on defense -- they've been playing without leading pass-rusher Joe Mathis and leading tackler Azeem Victor -- but it didn't matter on this night. Washington freshman safety Taylor Rapp intercepted two passes in the third quarter, taking one back to the house. Ezekiel Turner picked off Sefo Liufau a third time to end the stifling frame. By the time all was said and done, Liufau's quarterback rating for the game sat at negative-9.5. Washington made sure that there was simply no opening for the Buffs to come back through on this night. And in winning by 31 points on the biggest stage of the college football night, the Huskies demonstrated their all-around versatility as a team and validated their No. 4 ranking -- the final spot in this season's playoff.
Monkey Business (TV series) Monkey Business was a UK TV series that premiered in 1998, focusing on the various primates living at Monkey World, a rescue centre and sanctuary for primates in Dorset, United Kingdom. The series featured Jim Cronin and Alison Cronin, directors of Monkey World, as they travelled around the world rescuing primates often from abusive situations, and bringing them to the Monkey World sanctuary. The goal of Monkey World was the rehabilitation of the rescued primates, who were then released to live within the sanctuary in as natural-a-habitat as possible. The series was narrated by Chris Serle. Monkey World Jim Cronin MBE was born and raised in the US and when he moved to England worked at various animal parks/zoos before co-founding Monkey World with long-time friend Jeremy Keeling in 1987. The pair leased an old pig farm and converted it into the sanctuary which now covers 65 acres. Jim's wife, Dr Alison Cronin, worked alongside Jim and is responsible for the day-to-running of the sanctuary, still nursing and feeding the animals herself. The position of Animal Director is held by Jeremy Keeling, who is also a hands-on member of staff. Production Monkey Business was produced by Meridian Broadcasting and ran for nine seasons on both ITV Meridian and Animal Planet. Those episodes also appeared the National Geographic Channel. After ten years of Monkey Business production, first by Tigress then Meridian ITV and finally by Athena Films on behalf of Meridian and Animal Planet Productions, Monkey Business ended its run with a three-part series called 10 Years of Monkey Business. Monkey Life Monkey Life, a follow-on series based on the work of Monkey World, was created in 2006 by Primate Planet Productions Ltd and was initially produced and directed by Athena Films before being taken-on wholly and produced in-house by Primate Planet Productions in 2008. Initially shown on Five and later on Pick in the UK, and on Animal Planet and other TV channels worldwide, Monkey Life is now in its eleventh season. The first season was narrated by Andy Serkis, famous for voicing Gollum in The Lord of the Rings movies. Seasons two through twelve have been narrated by British actor Ralf Little. Animals Chimpanzees The chimpanzees are divided in four groups. Paddy's Group were the first chimpanzee group to form at Monkey World when it opened in 1987. The leader Paddy passed away in 2016 and was succeeded by his son Bart. The Bachelor Boys, an all-male group which formed in 1996 to take in male chimps that did not fit into mixed sex groups. One of its most famous residents was named Charlie, rescued by Cronin from a beach photographer in Spain who was using the chimp as a prop. Hananya's Group was formed in 1998 and was originally led by Charlie before his move to the Bachelor Boys. He was succeeded in 1999 by Rodney, who led the group until his death in 2004 and was succeeded by his second-in-command Hananya. The internal politics within these groups determine how long each male is leader. The Nursery Group led by Sally and Lulu, took in chimps that arrived at the park at a young age or were born at the park who had been rejected by their mothers and would care for them until they were old enough to join one of the adult groups. Sally passed away in 2018 and was succeeded by one of her wards Bryan. Orangutans Originally the only orangutans at the park were Amy (who had been at the park since it opened in 1987) and her mate Banghi (who arrived in 1988). Their son Gordon was born in 1997. Banghi passed away in 1998. Amy and Gordon were later joined by other female orangutans named RoRo, Lucky, Hsiao-Quai and Hsiao-Lan and an adult male named Tuan, who served as leader of the group. In later years, the group split into two; one led by Gordon and another led by Tuan. In 2005, an Orangutan nursery was formed to take in young orangutans born at Monkey World or European zoos that were orphaned or rejected by their mothers. The foster mother of the group was A-Mei until her move to Tuan's Group in 2015 and is now led by Oshine, who arrived at the park in 2010. Other primates The other 14 species include woolly monkeys, capuchins, squirrel monkeys, marmosets, cotton-top tamarins, siamang gibbons, golden-cheeked gibbons and other gibbons. Monkey World is part of the international species breeding program for golden-cheeked gibbons, orangutans and woolly monkeys. External links Monkey World official site watch Monkey Business on Discovery Broadband Monkey Business page on Animal Planet UK Category:1998 British television series debuts Category:Animal Planet original programming Category:ITV television programmes Category:Television series by ITV Studios Category:Television programmes produced by Meridian Broadcasting Category:1990s British television series Category:English-language television programs Category:Television series about monkeys Category:Television shows set in Dorset
Soak spinach in cold water and add 2 tbsp of vinegar. Leave spinach in the water for 20 minutes. Wash and drain it one more time.In a large pot, take vegetable oil add chopped onion. Stir and cook until onion is tender. Add tomato paste and red pepper paste stir for 2-3 minutes. Chop spinach and add it to the pot. Stir until it loses its volume. Add ground black pepper and salt. Turn the heat off when the spinach absorbs all of its juice and let it cool.For the sauce; take eggs, milk and vegetable oil in large mixing bowl and whisk. Brush bottom and sides of a 13 by 17-inch baking tray with vegetable oil. Layer the first sheet, spoon 1/3 of the sauce over entire surface. Layer the second sheet and spoon 1/3 of sauce over and spread the filling all over covering the whole surface. Layer the third sheet on top of the filling and spoon the remaining sauce all over and layer the last sheet. Whisk egg yolk for the glaze and brush the last sheet with egg yolk. Sprinkle some sesame and nigella seeds. Preheat the oven to 350 F. Bake for about 45 minutes or until nicely brown. When it completely cools down, cut the borek into squares. Preheat the oven to 350F.Sift flour, cocoa powder, vanilla sugar, and baking powder together in a bowl. Whisk eggs and sugar in another large mixing bowl until it gets creamy. Gradually add milk, vegetable oil whisking consistently. Add sifted flour, cocoa powder,vanilla sugar, and baking powder to the bowl and whisk thoroughly. Add hazelnut to the bowl and stir. Pour this mixture to a 10" non-stick round cake pan and bake it for 45 minutes. Check the cake by inserting a toothpick into the center. The toothpick will come out clean when the cake is done. Remove the pan from oven and pour the sour cherry juice all over. Let it cool on the counter top and keep it in the refrigerator. Decorate it with chocolate sauce when you serve. Monday, December 13, 2010 Preheat the oven 400F. Drizzle 2 tbs of olive oil on the bottom of baking dish and place the tilapia fillets side by side. Sprinkle all the spices evenly on top of the fillets. Drizzle 2 tbsp of olive oil on top. Bake it until nicely brown. Take green lentil in a medium pot and add enough cool water to cover. Cook over medium heat.Drain excess water and set aside.Take bulgur in a mixing bowl and add 1/2 cup of boiling water on it. Mix and cover the lid. Let the bulgur soak the water for 15 minutes. Take green lentil and bulgur into the mixing bowl and mix.Meanwhile, cut onion into halves and slice them thinly. Take olive oil and sliced onion into a medium size of skillet and saute it for 10 minutes over medium heat. Then add grated carrot to the skillet and saute it for another 10 minutes. Take sauteed onion and carrot to the mixing bowl.Add chopped green onion, chopped parsley, chopped mint, sumac, lemon juice, black pepper and salt to the mixing bowl and mix.
Q: When to pass event as parameter in functions (Javascript)? I am new to Javascript events I encountered many examples in which event is passed as a parameter to the function. So is it mandatory to pass event to each and every function and when not to pass it. As in below code event is passed in 2nd function. I am confused when to pass and when to not pass ? var elem = document.getElementById('my-elem'); elem.addEventListener('click', function(){ //the element has been clicked... do stuff here }, false); $('#my-elem').click(function(e) { //the element has been clicked... do stuff here }); A: You don't pass the event, it is done automatically by the browser in all standard event triggers. The question is do you need to receive the event as a named argument in all your functions and the answer to that is, it all depends on whether you are going to want to use it: When you will need access to the event: element.addEventListener("click", foo); // You can explicitly declare a function argument that will represent // the event object that is automatically passed to you by the browser function foo(evt){ // And, then you can access the event in the function evt.xyz... } When you won't need access to the event: element.addEventListener("click", foo); // The event is still passed to the function, but now, you don't // have an explicit way to access it: function foo(){ } Again, the event will be passed in all circumstances, so it's not going to improve or decrease performance if you decide to capture the reference with an argument. As a general rule of thumb to get started, it's probably a good idea to get into the habit of adding a named argument for it, so that if you need access to it, you can get it easily.
1. Technical Field of the Invention The present invention relates to yokes for use in rotary electric machines such as, for instance, starter motors, and, more particularly, to a yoke and a method of manufacturing the yoke. 2. Description of the Related Art In related art, attempts have heretofore been made to provide a method of manufacturing a yoke for use in a starter motor or the like as disclosed in Japanese Patent Provisional Publication No. 64-60247. In the related art shown in FIG. 6, a steel plate 100, cut out in a rectangular shape, is rolled in a cylindrical configuration. During such rolling, a manufacturing method is carried out by causing protrusions 110, formed on one end of the steel plate 100, to be brought into mating engagement with concave portions 120, formed on the other end of the steel plate 100, after which a central area of each protrusion 110 is press caulked in an expanded portion through which the protrusions 110 and the concave portions 120 are coupled to mechanically joint the both ends 100a, 100b of the steel plate 100. In such a manufacturing method, when rolling the steel plate 100 in the cylindrical configuration, an inlet of each concave portion 120 is formed in a size equal to or slightly less than a width of each protrusion 110 so as to enable the protrusions 110 and the concave portions 120 to be brought into mating engagement with each other in a circumferential direction as shown by an arrow in FIG. 7A. Further, under a condition where the protrusions 110 and the concave portions 120 remain in mating engagement with each other, a clearance 130 is formed between an outer periphery of each protrusion 110 and an inner periphery of each concave portion 120 as shown in FIG. 7B. Subsequently, as shown in FIG. 7C, a central area of each protrusion 110 is press caulked at PW and a peripheral area of each protrusion 110 is expanded to plug the clearance 130 whereby both ends 100a, 100b of the steel plate 100 are mechanically jointed. However, the related art method encounters various issues listed below. a) Under a status where the protrusions 110 remain in mating engagement with the concave portions 120, the clearance 130 is formed substantially around each protrusion 110 and, therefore, it becomes hard for the peripheral area of each protrusion 110 to be uniformly expanded upon punch caulking. This results in increased probability where the clearance 130 is left between each protrusion 110 and each concave portion 120 with the resultant occurrence of issues in airtight capability and reduction in mechanical joint strength between each protrusion 110 and each concave portion 120. b) If a localized expanding portion, formed by punch caulking, is dislocated toward a distal end of each protrusion 110, that is, when a localized expanding portion increases in greater extent toward the distal end of each protrusion 110, a force is exerted to the yoke to cause the protrusions 110 and the concave portions 120 to be drawn apart from each other, causing deteriorated precision in an inner diameter and roundness of the yoke.
TAMIU Alumni Notes What’s new with you? We’d like to know! Submit your alumnote today, and we'll share it with the rest of the University community in the next issue of the TAMIU E-news. The E-news includes local and regional alumni and University news and a calendar of just-around-the-corner events. Graduates who register for a lifetime e-mail account will automatically receive the Office for Alumni Relations E-News. To subscribe, send us an e-mail. TAMIU Alumni E-news Archive Want to see an older version of the Alumni E-news? Click here to visit the archive!
Depression is a cause of excess disability, morbidity and mortality in older persons and often remains unrecognized. Standard methods for diagnosing depression may miss significant pathology in "normal" elderly; their validity in the presence of dementia has not even been tested. A proposed program will screen a community-based sample of older persons for overt major depressive disorder and masked depressive disorders. Similar methodology will be used to identify secondary and/or coexisting psychiatric symptoms and to diagnose affective disorders in individuals with dementing illness. In those with putative syndromes, diagnoses will be derived from medical, psychiatric and psychological workups. The syndromes will be characterized in terms of symptom clusters, individual and family psychiatric histories, functional impairment, and biological markers. Their similarity to depression as present in the general population will be determined by determining the similarity of response to treatment of a controlled trail with a standard tricyclic antidepressant drug. The treatment study will also examine the impact of treatment on both cognitive and functional abilities.
/* * Copyright 2010, Red Hat, Inc. and individual contributors as indicated by the * @author tags. See the copyright.txt file in the distribution for a full * listing of individual contributors. * * This is free software; you can redistribute it and/or modify it under the * terms of the GNU Lesser General Public License as published by the Free * Software Foundation; either version 2.1 of the License, or (at your option) * any later version. * * This software is distributed in the hope that it will be useful, but WITHOUT * ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS * FOR A PARTICULAR PURPOSE. See the GNU Lesser General Public License for more * details. * * You should have received a copy of the GNU Lesser General Public License * along with this software; if not, write to the Free Software Foundation, * Inc., 51 Franklin St, Fifth Floor, Boston, MA 02110-1301 USA, or see the FSF * site: http://www.fsf.org. */ package org.zanata.webtrans.server.rpc; import edu.umd.cs.findbugs.annotations.SuppressFBWarnings; import net.customware.gwt.dispatch.server.ExecutionContext; import net.customware.gwt.dispatch.shared.ActionException; import javax.enterprise.context.RequestScoped; import javax.inject.Inject; import javax.inject.Named; import org.zanata.async.AsyncTaskHandle; import org.zanata.async.AsyncTaskHandleManager; import org.zanata.dao.ProjectIterationDAO; import org.zanata.model.HProjectIteration; import org.zanata.security.ZanataIdentity; import org.zanata.service.TranslationArchiveService; import org.zanata.webtrans.server.ActionHandlerFor; import org.zanata.webtrans.shared.rpc.DownloadAllFilesAction; import org.zanata.webtrans.shared.rpc.DownloadAllFilesResult; import java.io.Serializable; /** * * @author Alex Eng <a href="mailto:[email protected]">[email protected]</a> * */ @Named("webtrans.gwt.DownloadAllFilesHandler") @RequestScoped @ActionHandlerFor(DownloadAllFilesAction.class) public class DownloadAllFilesHandler extends AbstractActionHandler<DownloadAllFilesAction, DownloadAllFilesResult> implements Serializable { private static final long serialVersionUID = -7396110455459731753L; @Inject private ZanataIdentity identity; @Inject private ProjectIterationDAO projectIterationDAO; @Inject private TranslationArchiveService translationArchiveServiceImpl; @Inject @SuppressFBWarnings(value = "SE_BAD_FIELD", justification = "CDI proxies are Serializable") private AsyncTaskHandleManager asyncTaskHandleManager; @Override public DownloadAllFilesResult execute(DownloadAllFilesAction action, ExecutionContext context) throws ActionException { HProjectIteration version = projectIterationDAO.getBySlug(action.getProjectSlug(), action.getVersionSlug()); if (identity.hasPermission(version, "download-all")) { AsyncTaskHandle<String> handle = new AsyncTaskHandle<String>(); String keyId = asyncTaskHandleManager.registerTaskHandle(handle); // TODO This should be in a service and share code with the JSF // pages that do the same thing try { translationArchiveServiceImpl.startBuildingTranslationFileArchive( action.getProjectSlug(), action.getVersionSlug(), action.getLocaleId(), ZanataIdentity.instance().getCredentials() .getUsername(), handle); } catch (Exception e) { throw new ActionException(e); } return new DownloadAllFilesResult(true, keyId); } return new DownloadAllFilesResult(false, null); } @Override public void rollback(DownloadAllFilesAction action, DownloadAllFilesResult result, ExecutionContext context) throws ActionException { } }
This is your chance to get your hands on a highly polished full power cool action shootout game. Super Spy Cats 2016 is an awesome game full of fun. It is highly polished and rich in features. Looking for high retention rates? looking for long gameplay and In app purchases?Invest your resources in this game! after you play it yourself you will alone understand what we are talking about.One of the typical products and the best of Splaygame. Variatied from the iconic cartoon cat ? mouse fight and protect the peace of the world.The game is built on the Unity 3D graphics. Smooth structures, reducing shock features, error on the series. Construction throughout the game plot and special tasks included in each table. With gameplay touches to shoot, tap to move, easy but difficult thoughts unthinkable.Be evaluated on the game news site, forums and articles specializing in game, we can say this is a game ? a source that you should not ignore Features Games built 4 maps, so to play a new map to complete the proposed level
Certificate in Technology in Distance Education and E-learning The certificate in technology in distance education is intended to place the study of contemporary educational technologies in the context of the goals of educational and training organizations. It provides students with in-depth knowledge and experience with the primary distance technologies in use today. UMUC values your privacy. The information you supply on this form will be used to respond to your request for information and may be shared with parties working on behalf of UMUC for limited purposes. For more details, read our privacy policy.
Fixation of the greater omentum for prevention of delayed gastric emptying after left hepatectomy with lymphadenectomy for cholangiocarcinoma. Delayed gastric emptying (DGE) sometimes occurs after left hepatectomy with lymphadenectomy. We performed fixation of the greater omentum to the peritoneum to prevent DGE and other complications in patients undergoing left hepatectomy with lymphadenectomy for cholangiocarcinoma. Patients undergoing left hepatectomy with lymphadenectomy for cholangiocarcinoma were divided into a fixation group (n = 9) and a nonfixation group (n = 10). In the fixation group, the greater omentum was sutured to the peritoneum 3 cm from the greater curvature of the stomach to prevent contact between the stomach and the cut surface of the liver. Mean age, sex, disease, and hepatectomy procedures were similar in the two groups. DGE developed in six patients in the nonfixation group (60.0%) versus no patients in the fixation group (P = 0.011). The total number of complications was higher in the nonfixation group (16 complications) than in the fixation group (3 complications; P = 0.003). Overall morbidity was higher in the nonfixation group (60.0%) than in the fixation group (22.2%). Postoperative hospitalization was longer in the nonfixation group (67.4 days) than in the fixation group (20.2 days; P = 0.0041). Fixation of the greater omentum to the peritoneum decreases the occurrence of DGE and other complications after left hepatectomy with lymphadenectomy for cholangiocarcinoma.
Ibrahimovic could stay with United, says Mourinho July 14 (Reuters) - Zlatan Ibrahimovic could be offered a new deal by Manchester United, the Premier League club's manager Jose Mourinho said on Friday ahead of a friendly with Los Angeles Galaxy. Speaking at a news conference on the eve of their first pre-season tour match in California, Mourinho left the door open to the Swede returning when he recovers from knee surgery. The out-of-contract Ibrahimovic, 35, was United's top scorer last term after joining on a one-year deal, but he was injured in April and is likely to be sidelined at least until December. "If the decision is to stay and wait until December -- he can't be back until them -- why not wait? We are speaking and changing ideas," the Portuguese coach told reporters. With Ibrahimovic out of action, Mourinho has brought in Belgium striker Romelu Lukaku from Everton for a fee put at about 75 million pounds ($98.27 million) by British media. Mourinho said United signed Lukaku because he is a ready-made Premier League player, having had lots of experience in England, which hopefully would allow him to fit in immediately. "Obviously there are other good strikers in football, but the Premier League is a very specific habitat, a difficult habitat for strikers, and normally they need some time to adapt but Lukaku has been in the Premier League for five seasons," he told reporters. "Now he comes to a club with different responsibilities in the right moment of his career. He is still a young player but he has years of experience in the Premier League and the Belgian national team. He will go into the Champions League, which was also his main motivation." Mourinho needed a player who knows how to score against defensive teams that, using his famous phrase, "park the bus". "Romelu is not a player that participates a lot in the build-up play. He is a player that normally plays in the last third," added Mourinho. "We had so many opponents last season that decided clearly to defend, closing spaces, playing with lots of defenders and defensive midfield players.
LAKE BUENA VISTA, Fla. -- Shin-Soo Choo is, by acclamation, a very good player with a lot to offer a major league team. But the speculative frenzy surrounding him at the winter meetings has more to do with falling dominoes than his stellar on-base percentage. Now that free agents Robinson Cano, Jacoby Ellsbury, Brian McCann, Carlos Beltran, Curtis Granderson and Mike Napoli are off the board, the focus naturally turns to Choo, a hit-by-pitch and OBP machine who has a special niche as a true leadoff hitter. He's sure to be a prime topic of conversation when agent Scott Boras emerges from his suite and gives his annual State of the Boras Corporation Clientele update in Orlando in the next day or two. A year ago at this time, most executives envisioned Choo as a nice five-year, $80 million player. He has yet to make an All-Star team or finish higher than 12th in MVP balloting, and he's a career .243 hitter with a .680 OPS against left-handed pitching. But the gusher of TV money and the baseball-wide run on hitters has accelerated the pursuit of Choo and sent the estimates of what it will take to sign him into orbit. Shin-Soo Choo is said to be seeking for a deal north of $100 million. Jamie Sabau/Getty Images Entering the offseason, Boras was looking for a deal with a total payout exceeding Jayson Werth's seven-year, $126 million agreement with the Washington Nationals in 2010. After landing Ellsbury with the Yankees for $153 million, Boras is seeking another huge payday for Choo. What will the team that ultimately signs Choo be getting? "For the next two or three years, he's probably going to be an elite on-base guy," said an American League executive. "He's a plus makeup guy. He'll give you some power and probably play average defense on the corners. He's a very good hitter, but he's 31 next year. If you sign him to a seven-year deal, you know you'll be looking at a significantly declining skill set over the last 3-4 years of the deal." Where could Choo ultimately land? Keeping in mind that the landscape can change at a moment's notice, here's a list of teams that have voids in the outfield or have been linked to Choo in media reports: The Rangers have engaged in some dialogue with Boras about Choo, but he's too pricey for their tastes at the moment. Barring a change, Texas could simply opt to bring back Nelson Cruz on a shorter-term deal. If Cruz returns and joins Alex Rios, Leonys Martin and the newly-acquired Michael Choice in the outfield mix, it's tough to see where Choo would fit in Arlington. They're in desperate need of an outfield bat. But after spending $240 million on Cano, how high are they willing to go on Choo? The Mariners and Red Sox are among the teams that have been mentioned as potential landing spots for Matt Kemp if the Dodgers move him in a trade. So that's another possibility. If Boras does take Choo to Seattle, the Mariners might want to consider a dual news conference involving both Cano and Choo. How much fun would it be to see Boras and Jay Z on the same podium? A lot of people considered the Tigers a sleeper for Choo, in part because of Boras' long-standing relationship with owner Mike Ilitch and success at steering big-ticket clients to Detroit. But the Tigers' outfield shopping is complete now that they've signed Rajai Davis to a two-year deal. Detroit's main objectives now are upgrading the bullpen and trying to sign Max Scherzer to an extension. That's not going to be easy. After dumping the Adrian Gonzalez and Carl Crawford mega-salaries and winning the World Series, the Red Sox don't seem inclined to jump into the deep end of the pool with another $100 million-plus free-agent deal. And if the Sox were going to spend nine figures on an outfielder, wouldn't they have made a more serious push to bring back Ellsbury? They need an outfield corner bat. But after spending $166 million on Hunter Pence, Tim Hudson, Tim Lincecum, Javier Lopez and Ryan Vogelsong, they're in bargain-hunter mode. It would make more sense to add a Michael Morse-type (or the real Michael Morse) to share time with Gregor Blanco in left field. There's also been some buzz about the Giants trading for Brett Gardner and moving Angel Pagan to left. He was a nice fit at the Great American Ball Park. But with $300 million-plus already invested in Joey Votto and Brandon Phillips, the Reds would have to see Choo's price drop considerably to have a reasonable shot at bringing him back. It's time for Billy Hamilton to set up shop in center field in Cincinnati. Chris Davis was the only Baltimore regular with an on-base percentage above .330 last season, so Choo (.423 OBP at leadoff last season) would be a welcome addition at leadoff. But Adam Jones, Baltimore's best player, is signed to a long-term deal for $85 million, so the Orioles would probably be hesitant to go much beyond that. The O's also face the prospect of Davis and fellow Boras client Matt Wieters hitting the free-agent market after the 2015 season. They might want to conserve their resources now to have any chance to bring back one or both of those players later. The Diamondbacks were always a long shot for Choo given their payroll limitations. Arizona has $65 million committed to seven players and a projected payroll of $100 million in 2014, so owner Ken Kendrick was going to have to seriously stretch the budget to fit Choo into the equation. Now that the D-backs have added Mark Trumbo in a three-team trade with the Los Angeles Angels and the Chicago White Sox to fill their need for a corner outfielder, Towers can turn his attention to his other offseason priority -- trying to deal for a workhorse starting pitcher. After adding Ellsbury and Beltran through free agency, the Yankees have six outfielders on the roster (Ellsbury, Beltran, Gardner, Alfonso Soriano, Vernon Wells and Ichiro Suzuki). With holes to fill at second base, third base, the starting rotation and the bullpen, GM Brian Cashman will probably take a pass on adding a seventh outfielder to the mix. Barring the addition of a "mystery" team to the list, those look like Boras' options. It doesn't necessarily bode well for Choo to land a deal of $130 million-plus for six or seven years. But feel free to stop us if you've heard that one before. If the first month of the Hot Stove season is any indication, we should probably expect the unexpected.
(function() { "use strict" module.exports = function trigrams(tokens) { const grams = []; tokens = Array.isArray(tokens) ? tokens : [tokens]; tokens.forEach((str) => { for(let i=0;i<str.length-2;i++) { grams.push(str.substring(i,i+3)); } }) return grams; } }).call(this);
Archives According to Nick Cafardo of the Boston Globe, the Boston Red Sox have been scouting Phillies lefthander Cole Hamels, with possible intent of constructing a deal to acquire him. “Hamels is Philly’s most tradeable commodity. They would have to score huge to make a deal. The Phillies have been scouting Boston heavily all season. At […] Without a doubt, one of the best perks of working for a baseball team is the access to players, coaches, scouts, and countless others with intimate knowledge of the game. I can’t say enough kind works about the Sky Sox staff who have, over the last six months, imparted a great deal of their knowledge to me about how the game is played. Recently, I sat down with Sky Sox catchers Paul Phillips and Michael McKenry – as well as a number of scouts and coaches – to pen an article on game calling and pitching sequencing; discussing both the basic and the finer aspects of calling a game from behind the plate… Jon Lester and Jeremy Guthrie have both factored into twelve decisions so far this season, earning a (9-3) and (3-9) record, respectively. Tonight, Lester will look to continue the Boston Red Sox’s successful record against the struggling Orioles. After a clean sweep of the Dodgers, the Boston Red Sox look to continue their dominance while the interleague season lasts, sending Jon Lester to the hill against youngster Jhoulys Chacin, who is sporting a cool 4.00 ERA since replacing Jorge de la Rosa in the Colorado Rockies rotation. Last night’s systematic dismantling of the Boston Celtics may have shaken your confidence in Boston sports, but fear not… Jon Lester returns to the mound tonight for the Boston Red Sox to take on Rodrigo Lopez and the Arizona Diamondbacks. Justin Masterson routing Clay Buchholz to embarrass his former team was a forgone conclusion? Say whaaaaaa? After a stunningly, shockingly, horrifyingly inane loss last night, the Boston Red Sox will scrape up their shattered dignity and finish an otherwise strong series in Cleveland. And what better man to slam the door than Jon Lester? Certainly not Boof Bonser… that’s for sure. Well at least we know the Royals didn’t sweep. With the month of May drawing to a close, Jon Lester will take the mound for the Boston Red Sox to face Bruce Chen in the last game of a troubling series against the Kansas City Royals. Don’t look now, but the Boston Red Sox are starting to win games against some of the toughest teams in the majors. Jon Lester will look to carry that momentum forward, as he faces James Shields of the Tampa Bay Rays, who has been simply dominant thus far in 2010.
(Reuters) - A gunman killed 12 people, including a sheriff’s deputy, when he walked into a Southern California bar and grill and started shooting on Wednesday night, police said. The gunman was also killed, Ventura County Sheriff Geoff Dean told a news conference on Thursday, though it was not immediately clear by whom. “It’s a horrific scene in there,” Dean said. The sheriff’s deputy who died was identified as Sgt. Slideshow (5 Images) When the shots started, some people smashed windows with chairs to escape, witnesses told CNN.feeds.reuters.com/~r/Reuters/domesticNew...wochit.com
All about my travels, adventures and shenanigans since 2001. Spent most of my years in India and now based in the US since 2015. Besides my home country, travel has taken me to various parts of the US, Europe and South-east Asia. I love exploring cultures, cuisines and new landscapes and interacting with people from all walks of life. Inherently curious with a passion for life and an innate need for sharing and telling stories! Heading for Chennai A few of us (Arun, Suman, his wife Chitra, Vasu) will be in Chennai over the long weekend (Jan 14-16). We will be working with Kiruba and Nanda who have been involved in such activities from Chennai. One of the activities will be to go into the nearby villages to identify families for sponsorship for folks who want to help from the US. The other is to distribute fishing nets, baby food, children school supplies in the nearby villages, which Kiruba has already been doing for the last few days. If you can pitch in terms of contributions, please contact me asap via email: anitabora5 at rediffmail dot com. Anything will be useful. Just read this report, forwarded by Anumita:Hungry villagers queuing up for food “For a village which has a 350 strong-population, Nambikkai Nagar is situated in no-man’s land. Each time a vehicle passes-by, villagers rush towards it, hoping that it would bring in relief — because, for the past two days even food packets have failed to reach them.” While many villages are getting an abundance of relief, it seems like a few are getting left out. Ah! okay. Maybe we can catch up on Friday. Since so many of us will be in town, we might do a meeting too on Friday/Sunday. I’ll mail you my contact details or you can keep in touch with Kribs. He should know my whereabouts! Subscribe to Blog via Email Instagram Partner with me If you're a brand/company in travel, lifestyle, fitness, gear, devices and accessories - please reach out to discuss how we can work together via my contact page. Please follow & like us :) All about my travels, adventures and shenanigans since 2001. Spent most of my years in India and now based in the US since 2015. Besides my home country, travel has taken me to various parts of the US, Europe and South-east Asia. I love exploring cultures, cuisines and new landscapes and interacting with people from all walks of life. Inherently curious with a passion for life and an innate need for sharing and telling stories!
Tag Archives: FUD I have plenty of better things to do than blog right this moment, but having been in the midst of events that generated an inordinate amount of FUD, I just couldn’t contain myself. NEWSFLASH: AN OPEN SOURCE CLOUD FRAMEWORK ACCEPTS CODE OpenStack Nova has not stopped supporting anything. Rackspace hasn’t done anything but start contributing code to support their APIs. Considering that Rackspace is actually spending real money to support the project, that seems entirely reasonable. (PROTIP: If a community is going to use an Open Source project to interact with your product, you might want to consider a strategic investment in making that experience a good one. Just Sayin’) THERE WAS NO STATEMENT, NO CODE, NOTHING WHATSOEVER THAT INDICATED OPENSTACK WOULD REMOVE SUPPORT FOR AWS APIS. @wattersjames proceeded to banter with @swardley in the twitterz, hilarity ensued, and now we are here. (+1 evil genius points to James) OMFGWTFBBQ, Rackspace is going to implement their APIs in an open source project that they have devoted resources towards. The Clouds are falling. Aside from people just getting their facts straight because it is the responsible thing to do, OpenStack is far and away one of the most open ‘open source’ projects by design, and definitely when compared with other open source cloud frameworks. There is a reason there are ~150 people in #openstack on IRC. There is a reason people are submitting patches. This isn’t because of Rackspace. This is because of how the community has been engaged and the promise of a truly open cloud framework. There are two other things worth noting for people who haven’t followed this story and can’t be bothered to get the facts straight. First, there are other entities involved in OpenStack, not the least of which is NASA. Maybe you have heard of NASA? I don’t think NASA is in this beholden to Rackspace. OpenStack will evolve in the direction that is a combination of the collective utility of the community and whoever chooses to actually contribute code. Which brings me to the second point, code wins. If you think something should work a certain way, prove it with code.
The present disclosure is related to the arrangement and operation of patient support apparatus with a sensor. More specifically, the present disclosure is related a patient support apparatus including an optical detector. Patient support apparatuses known in the art include barriers, such as siderails and end panels for example, that are coupled to the patient support apparatus and may be positioned to block a patient from entering or exiting a patient support apparatus. Some barriers are equipped with user interfaces having user input devices such as buttons or keyboards for inputting information. Such user input devices sometimes require multiple button presses or keystrokes to enter information into a control system for the patient support. Entering information with multiple button presses or keystrokes can increase the amount of time a caregiver spends at a patient support apparatus. Additionally, information entered via multiple button presses or keystrokes can include mistakes from time to time.
Politico and Huffington Dredge for Dirt with Rick Perry Gay Rumors A story by Politico predicts that if Texas governor Rick Perry runs for president, he will again have to deal with unproven rumors that he’s gay. Meanwhile, the story itself is helping spread the rumors once more. The Drudge Report linked to the speculation with the headline “Media Digs Up Rumors.” On the more liberal side of the political spectrum, The Huffington Post wrote up a story about the “Rick Perry Gay Rumors.” Politico reports that “the crusted-over rumors were in the ether among some attendees at a dinner hosted last week by the Manhattan County GOP, where Perry gave the keynote speech.” And it reminds readers that Perry was once backed into doing an interview with an Austin newspaper specifically to rebut the notion in 2004. “As you may know, Rick and Anita Perry first met in grade school, went on their first date together in 1966, have been lovingly married since 1982 and are parents to two grown children,” according to Dave Carney, a Perry strategist quoted by Politico in defense of the governor’s marriage.
Differences between accumbens core and shell neurons exhibiting phasic firing patterns related to drug-seeking behavior during a discriminative-stimulus task. The habit-forming effects of abused drugs depend on the mesocorticolimbic dopamine system innervating the nucleus accumbens (NAcc). To examine whether different NAcc subterritories (core and medial shell) exhibit a differential distribution of neurons showing phasic firing patterns correlated with drug-seeking behavior, rats were trained to self-administer cocaine, and activity of single NAcc neurons was recorded. In the presence of a discriminative-stimulus (S(D)) tone, a single lever press produced an intravenous infusion of cocaine (0.35 mg/kg), terminated the tone, and started an intertone interval ranging from 3 to 6 min. Lever presses during this intertone interval had no programmed consequences. In addition to evaluating neuronal firing patterns associated with cocaine-reinforced presses, we also evaluated firing patterns associated with unreinforced lever presses to allow interpretation of firing free of factors other than the instrumental response (such as tone-off and onset of the pump signaling drug infusion). Core neurons exhibited a greater change in firing than medial shell neurons both in the seconds preceding the reinforced and unreinforced lever press response and in the seconds following the unreinforced response. Core and medial shell neurons exhibited similar changes in firing during the seconds following the cocaine-reinforced press. The differential distribution of neurons exhibiting phasic changes in firing preceding the lever press suggests that the physiological activity of core neurons may play a greater role than that of medial shell neurons in processes related to the execution of conditioned drug-seeking responses.
Of all the occupations in the United States, which has so few practitioners that if you got them all together — a possibility since there are only 310 of them — they’d comfortably fit in a middle-school auditorium? (Maybe not in those eighth grader-sized seats, but they could all be accommodated.) Need a hint? They comprise one of the nine specialties recognized by the American Dental Association, specializing in the restoration of natural teeth or replacing missing teeth or oral structures with artificial devices, such as dentures. These would be prosthodontists. The fun little statistical compilation that got posted last week has numbers for the biggest and smallest occupations. Biggest? Why that would be retail sales clerks whose 4.34 million workers represent 3.3% of America’s labor force. Followed by the 3.31 million cashiers, accounting for 2.5 percent of workers, and 2.94 million fast-food workers, servers, and food-prep folks, which are 2.3 percent. It appears whoever said someday we’ll be working for Walmart or McDonald’s may have been on to something. Mapping Recruiting’s Tech Click for bigger size Having now clarified why it is so difficult to hire prosthodontists or fabric menders, here’s help understanding who’s who in talent acquisition. Yeow! If nothing else, you have to give Headhunter Labs credit for sticking its neck out on this one. Without breaking a sweat, I came up with 10 or 11 vendors not on the list. And I know what happens if you fail to mention a vendor: they call, write, or comment. PS: Feel free to post your missing company in the comments below. And, good luck to the Labs guys there in NYC. About the author John was a newspaper reporter and editor until his geek gene lead him to launch his first website in 1994. Never a recruiter, he instead built online employment sites and sold advertising services to recruiters and employers. As VP of one large media operation, his employment revenue alone approached $2.5 million. Besides writing for ERE, John consults with digital content operations, focusing on the advertising side. And when he's not doing either, he can be found hiking in the California mountains or competing in canine agility events.
Q: How would I do the C++ equivalence of dynamic cast in TypeScript? In C++ there is dynamic cast that checks at runtime if an object implements and interface and returns a nullptr instead of the object if it does not. How can I do the same thing in TypeScript. The way that I can think of is to check the existence and type of each property: interface MyInterface { value: string; lastUpdated: number; deleted: boolean; } let obj = JSON.parse(inputdata); if ('value' in obj && 'lastUpdated' in obj && 'deleted' in obj && typeof obj.value === 'string' && obj.lastUpdated === 'number' && obj.deleted === 'boolean') { // do something } else { // null case } Since TypeScript interfaces are not available at runtime I can't even write helper functions to generalize these checks. Is there a better to do dynamic casts in TypeScript? A: I believe you get what you are asking for if you implement a type guard interface MyInterface { value: string; lastUpdated: number; deleted: boolean; } function isMyInterface(obj: any): obj is MyInterface { // You don't really need the first three, just the last three return 'value' in obj && 'lastUpdated' in obj && 'deleted' in obj && typeof obj.value === 'string' && typeof obj.lastUpdated === 'number' && typeof obj.deleted === 'boolean'; } let obj = JSON.parse(inputdata); if (isMyInterface(obj)) { // do something, compiler knows obj is a MyInterface in this block } else { // null case }
1. Field of the Invention The present invention relates to an electric power distribution device, in particular, to an electric power distribution device for supplying electric power to a stator coil that arranges on a motor-rotation axis centered circle. 2. Description of the Related Art Recently, needs for reducing the fuel cost of a vehicle has become large, and for example, a development of the super-low fuel consumption hybrid vehicle is under development. Especially recently, a hybrid car with a motor assistance mechanism which assists an engine by a brushless DC motor when gathering speed is proposed. The motor for use in the motor assistance mechanism includes a rotor directly coupled to a crankshaft of an engine, and a ring-shaped stator surrounding the rotor. The stator is composed by a lot of magnetic poles formed by coil a core, a stator holder for receiving the magnetic pole, and a concentrated electric power distribution device for supplying electricity to the coil intensively. FIG. 13 shows a conventional concentrated electric power distribution device disclosed in Japanese published patent application No. 2003-134724. As shown in FIG. 13, the concentrated electric power distribution device includes three bus bars 22a, 22b, 22c corresponding to each layers of a motor, and an insulating holder 21 receiving the bus bars 22a, 22b, 22c in a manner the bus bars are insulated to each other. As shown in FIG. 14, the bus bars 22a, 22b, 22c are formed by stamping a conductive metal plate 91 in a band shape, and bending the metal plate in a thickness direction thereof to form a substantially circular shape, where diameters of the bus bars are different from each other. Terminals 50v, 50u, 50w connected to a battery and tabs 41a, 41b, 41c connected to the coils of the stator are formed in a width direction at a far side from the insulating holder 21. Circular receiving grooves having the same radiuses as the bus bars 22a, 22b, 22c are formed on the insulating holder 21. However, according to such a conventional concentrated power supply member, the bus bars 22a, 22b, 22c are curved in a length direction. Therefore, after stamping the metal plate, a bending machine bends the bars in whole lengths. Further, when curving the bus bars 22a, 22b, 22c by a press metal mold, it is necessary to divide the length direction into the plural for pressing. Therefore, a processing man-hour increases and it becomes a problem about the cost. Further, because the curving radiuses of the bus bars 22a, 22b, 22c are different, the bus bars 22a, 22b, 22c cannot be curved once. Further, two or more set of the bus bars 22a, 22b, 22c cannot arranged in a width direction of the metal plate 91. Therefore, the manpower and the production cost increases. It is necessary to raise the processing accuracy when curving the bus bars 22a, 22b, 22c. If the curving radiuses of the bus bars 22a, 22b, 22c are different from those of the receiving grooves of the insulating holder 21, it is hard to receive the bus bars 22a, 22b, 22c in the receiving grooves of the insulating holder 21, and working ability decreases. Accordingly, an object of the present invention is to provide an electric power distribution device with which the manpower of producing the bus bars can be reduced, and producing the bus bars at low cost.
Q: Are bike saddles always removable from the saddle post? I want to buy a mountain bike soon and I’ve been doing a bunch or research. I noticed that some bike saddles can detach from the top of the saddle post, while others get removed with the whole post. There are a couple of things I want to know. Can all saddles be detached from the top of the saddle post? Are saddles that detach with the post of cheaper quality? that’s it, thank you A: Saddles are always removable from the seatpost or, in some cases, the seat mast. I am not aware of any arrangements where the saddle is made in one piece with a seatpost or equivalent part. Because saddles are extremely personal, and even a rider's own saddle preference can change over time, it seems unlikely that there are such construction arrangements - I suppose a weight weenie cyclist might be willing and able to make or commission a saddle without rails bonded to a carbon seatpost or seat mast topper, but that would be very niche application. It would also be pointless, because most high end stock rim brake bikes and even a number of disc brake bikes can be brought under the UCI weight limit. That said, a very small number of bikes have a seat tube that extends up from the top tube, which I believe is called a seat mast. You would clamp your saddle in a seat mast topper, then mount that on the mast. You would cut the seat tube to the correct length, and the mast topper offers a small range of height adjustment in case you need to change your saddle height. Probably the most prominent example is the Giant TCR, pictured below. The picture is from this Velonews Q&A session with Lennard Zinn, where he fields a couple of letters from readers who are trying to extend a mast that had been cut, or else to just get a bit more saddle height than their cut mast allowed for. This neatly illustrates the potential downside of the seatmast design. To the original question: in this arrangement, I suppose you could just remove the seatmast topper along with the saddle. However, the saddle is manufactured separately from the topper - or else how would you change your saddle horizontal position? Why on earth would anyone make such an item? It could be lighter than seat tube and seat post arrangement, although remember that the impact of small amounts of weight on cycling performance are negligible. Open Cycles uses a seat mast arrangement on its Open MIND bike, and their webpage says that it allows them to make the seat tube very thin, at about 25mm - recall that a thinner tube should have more compliance than a thicker one, which should increase comfort. Alternatively, Speedvagen is a small batch steel frame builder, and as best as I can determine, the seat mast arrangement is an aesthetic choice only, and it's one of their signature design elements. A 2008 article from Road Bike Action discusses some of the potential advantages of seatmasts, but I believe some of the arguments are incorrect (e.g. aerodynamic seat tubes and posts are more widely available today, although the post tends to be proprietary to each frame). If my memory is correct, seatmasts may have had a brief bloom in popularity in the late 2000s and early 2010s, but clearly they have not become widely accepted.
Q: C exit codes and atexit() in a realtime / non-batch app I'm writing a game in which a number of different conditions can cause a failure, for example an image or shader failed to load, OpenGL failed to get a valid context, etc. In an ideal world, I'd like to use exit codes in the way I believe was intended for C, i.e. non-zero for failure conditions. However, there are some factors that play into this: In using non-zero exit codes, atexit() is not called, unfortunately for me as my program cleanup is handled hierarchically via a single atexit() registration in main(), which I like. It occurs to me that given the nature of the application - a game has an indefinite running time unlike a batch program - there may never be a practical situation in which the exit codes are actually used. It's not like e.g. a command line image converter called by a Makefile which needs to know whether the program succeeded or failed via its exit code, thus determining whether or not to continue with the build. The likelihood is that if anything is wrong with the program at runtime, such as missing files, that's a problem I fix myself, then proceed smoothly. What arguments can be made for and against using non-zero exit codes in my situation? A: Triggering registered atexit() functions Contrary to your question, functions registered with atexit() are still called even when the program attempts to return a non-zero termination status to the host environment. A call to exit(), or the main() function returning, will trigger the functions registered with atexit(), regardless of the value given. Example: #include <stdlib.h> #include <stdio.h> void print_stuff() { puts("Stuff"); } int main() { atexit(print_stuff); exit(1); } This will print Stuff, even though 1 is returned. Technical details By the ISO C standard, the functions registered in atexit() are called after exit() is called. The following situations are also defined as calling exit() (and therefore triggering the functions registered with atexit()): main() returning is equivalent to calling exit(). After the final thread calls thrd_exit(), exit(EXIT_SUCCESS) is called. The following are possible implementation-defined sources of calling exit(): The default signal handler for SIGTERM. The default constraint handler before using set_constraint_handler_s(). The standard mentions the following situations where exit() and the calls to functions registered with atexit() are circumvented: An unhandled SIGABRT or a SIGABRT that finishes being handled by a function registered with signal(). SIGABRT can be raised by abort(). Calling _Exit(). Calling quick_exit(). The host environment for your implementation may terminate the program in some situations without calling functions registered with atexit(), such as after a segfault. Regarding exit codes for a game Your choice of exit code shouldn't matter too much for a game. Yes, you won't be relying on a shell script to run your game and report errors to the user. Error feedback is probably more useful in the form of dialog popups, a log, or stderr for systems like Linux.
The sound that some of the biggest "smaller" birds make, better known as pigeons. Usually hanging around parks and within downtown areas of large cities, these pigeons make a characteristic "cooing" sound.
After years of offering an ever-expanding menu of perks to their cardholders, several major credit card companies are going in the opposite direction — eliminating or reducing the value of some of these extras. One of the major reasons for using a credit card — aside from fraud protection and any rewards you might get — is the buffet of free benefits available, such as price protection, extended warranty coverage, flight insurance and trip cancellation coverage. But now, some of those extras are being dropped. Discover did its roll-back in February, Chase made changes in June and Citi’s cutbacks take effect at the end of July. Industry analysts expect more card companies to follow suit. “Credit card issuers are always tinkering to see what people like — what’s working and what’s not,” said Matt Schulz, senior industry analyst at creditcards.com. “What we’re seeing is the elimination of some perks, like price protection and return protection, that have been around a long time, but aren’t necessarily all that popular. And when a perk isn’t used that often and it costs the issuer money, the perk may not stay around for very long.” When it comes to offering rewards and benefits, the prevailing theory had been “more is better.” But that strategy doesn’t work when so many cards offer the same features. A report by Market Strategies International concluded that “The arms race to offer more benefits is not an effective solution for winning and retaining card users.” The report, published earlier this year, found: Most people (80 percent) are “unclear” about the benefits that come with their primary credit card. More than half (52 percent) said they “know little or nothing” about the added features. Consumers want a card that has no annual fee, offers cash back and has a low interest rate. Mike Berinato, vice president of research and consulting at Market Strategies International, expects more credit card companies to reduce their perks. Most people (80 percent) are “unclear” about the benefits that come with their primary credit card and more than half (52 percent) "know little or nothing" about the added features. “It’s smart business,” Berinato told NBC News BETTER. “The credit card companies are not getting more cardholders this way and they want to save money by not offering benefits that nobody is using.” Here’s a look at the changes that have or are about to take place at Discover, Citi and Chase. Discover As of Feb. 28, Discover cards no longer provide these five benefits: Return Guarantee Purchase Protection Extended Warranty Protection Auto Rental Insurance Flight Accident Insurance Brittney Mitchell with Discover public relations, said the company regularly evaluates cardmember benefits “to ensure that we are meeting or exceeding our cardmembers’ current needs and expectations. The changes were made because of “prolonged low usage,” she said in a statement to NBC News BETTER. Chase In April, Chase removed Price Protection and Return Protection on its United Explorer Credit Card. It also lowered Trip Cancellation Coverage. Chase said it made these changes because only “a small percentage of cardmembers were taking advantage of these benefits.” They were replaced, Chase said, with benefits that were more valuable for all cardholders, including “the opportunity for the vast majority of our cardmembers to earn more miles every month.” Chase is in the process of notifying its customers, including those who have its highly-rated and popular Chase Sapphire Reserve card, about the changes that will take place on Aug. 26. Here are the major ones: Price Protection is eliminated for all Chase branded cards. Return Protection will no longer be offered for the Chase Freedom, Freedom Unlimited, Sapphire, Sapphire Preferred, Ink Plus or Ink Preferred cards. Chase Freedom Visa Signature cardholders will no longer have Lost Luggage Reimbursement and Travel Accident Insurance. Trip Cancellation/Interruption Insurance is now lowered from a maximum of $5,000 to $1,500 for each covered person per trip. Chase says this is being done to standardize the benefits for its Freedom, Freedom Unlimited, Visa Platinum and Signature cards. In a statement to NBC News BETTER, Lauren Ryan, communications director for Chase Card Services said: "We are always evaluating our products to offer a great mix of rewards, benefits and experiences that provide the most value to our customers — and those they tell us they value most. In order to do so we may need to occasionally retire lesser used benefits.” Citi Cards Here are some of the key changes that are effective on July 29: Some cards, including Double Cash and Simplicity will no longer offer Roadside Assistance Dispatch Service and Travel & Emergency Assistance. The Citi/AAdvantage Bronze card will no longer offer Lost Baggage Protection. The 90-Day Return Protection no longer covers firearms, tires, jewelry, furniture or appliances. “Citi Price Rewind” (the service that searches online for a lower price than you paid for that item and refunds the difference) drops from a maximum of $500 per item and $2,500 per year to $200 per item and a maximum of $1,000 a year. Price Rewind no longer applies to lower prices found at warehouse clubs where there’s a membership fee. Trip Cancellation & Interruption Protection drops to $1,500 per trip and $5,000 per calendar year from $3,000 per person per trip with no annual cap for some cards, including Double Cash and Simplicity. And this coverage is now limited to you and your family members. For other cards with an annual fee, Trip Cancellation will change to $5,000 per trip from $5,000 per person per trip and coverage will be limited to you and your family members. In a statement to NBC News BETTER, Jennifer Bombardier, vice president of public affairs for Citi Global Cards, said: “Citi continuously evaluates our products to ensure that associated benefits best meet the needs of our customers. As such, we are making changes to select credit card protection benefits effective July 29, 2018, so that we can continue providing key benefits that our customers use and value most at no additional cost.” American Express goes the opposite direction American Express recently notified cardholders that it will improve Price Protection and Extended Warranty Protection starting August 1. Price Protection coverage will be increased from 90 to 120 days. Extended Warranty Protection is being greatly enhanced: If the original manufacturer’s warranty is less than two years, AMEX will match the length of that warranty. If the original manufacturer’s warranty is between two and five years, AMEX will increase coverage to provide two additional years. Credit card perks can save money You may not choose which cards to have in your wallet based on its perks, but if the credit card company is giving you something for free, you might as well take advantage of it. And some of the benefits being offered — airport lounge access, cellphone protection, lost luggage protection, trip interruption or cancellation coverage, roadside assistance and payment of TSA PreCheck fees — can save you some serious money. If you haven’t done it in a while — or ever — go to your card issuer’s website and take a look at the free benefits. There might be something there that’s right for you. HOW TO SAVE MORE MONEY Want more tips like these? NBC News BETTER is obsessed with finding easier, healthier and smarter ways to live. Sign up for our newsletter.
Tag Archives: Department of Agriculture & Markets A local politician wants to make sure supermarkets are making the grade — 24 hours a day. Senator Tony Avella has proposed that the city’s Department of Health and Mental Hygiene be given jurisdiction over food markets in the five boroughs, an authority only the state’s Department of Agriculture & Markets currently has. “I mean part of the problem is that the city has no jurisdiction over supermarkets. I mean obviously the state doesn’t have the proper number of inspectors,” Avella said. “When there is a complaint, there is the issue of a timely inspection.” There are approximately 115 food inspectors who have jurisdiction over more than 28,000 markets. Avella brought up the example of the Hillside Avenue Halal Market that had received numerous complaints. One of the complaints was that meat and poultry was being delivered in an unrefrigerated truck, but since the deliveries came at night, there was no way for the Department of Agriculture to find out — no inspections after 5 p.m. “[The city] makes night inspections, and they can have quicker response time. Why not have the city have some jurisdictions,” Avella asked. Under the proposal, the city and state would have concurrent jurisdiction. Avella also said giving the city jurisdiction would stop restaurants from classifying themselves as food markets to evade the city health inspectors. Currently, the city’s health department inspects and hands out letter grades to restaurants. Avella said expanding the letter grades to markets may be something that is discussed in meetings with the city. “I think it’s a real consumer issue. This will make sure [markets] are following the code,” Avella said. “There is the opportunity for more routine inspections to make sure it is safer for everyone. I think it’s a no brainer”
import React from 'react' import { Grid, Row, Col } from 'react-styled-flexboxgrid' export default ({ children }) => ( <Grid> <Row> <Col xs={12}>{children}</Col> </Row> </Grid> )
Do you have the right tools in your garage? This must-have garage tools list can help you figure out what’s right for your needs. INTERIOR DECORATING TIPS AND TRICKS It seems that these days every time you scroll through one of your social media feeds, more and more articles are featuring the general theme of living a minimalist type lifestyle along with tips for getting more out of less. BENEFITS OF INTEREST OFFSET ON YOUR HOME LOAN If your home loan has a variable interest rate, there is a high possibility that you have the choice of a 100% offset. Are you having plumbing problems in your home? If you are nodding to that question, you join the thousands if not millions of people around the world who experience some sort of plumbing disaster at some point. Luckily for you and all the others like you, there are companies like Plumbdog which are always available to help you in your time of need. What do these companies do? Generally, plumbing services stick to issues that are related to your water pipes, bathrooms, taps, drainage and septic tanks. But sometimes you need a little bit more from a plumbing service. Here is a list of services you can expect from versatile plumbing companies. Plumbing Of course, these companies will assist you when you want any plumbing installations or any repairs done. They will come over at a moments notice when you have an emergency and help you with laying new pipes if you are expanding your home. Gas Companies that wish to provide their customers with a range of services will also help you when you want to install a gas line or fix any leaks in your gas line. They will, of course, be certified to handle these situations as it calls for specialized training and know how to manage gas line related matters. Drainage Blocked drainage can be a real messy situation for any home. It can happen due to many reasons and mostly due to hairs, tissues and other debris getting caught up in the lines. If you have a blocked drain, you need to call a company that can get out all the things that are causing the block and allow for the waste water to flow freely. Hot water system installation If you want to install a hot water system in your home, you need an expert plumbing services that can do the required fittings and modifications so that you can enjoy a nice hot bath when you need. It will need an inspection of the existing plumbing system so that the technicians can tell you what changes need to be made in order for you to install a hot water system in your home. Other services Many plumbing companies will offer maintenance and regular check up services for your plumbing and gas systems. These will cost you a small yearly fee but in the long run, it can benefit you as they will be able to identify any problems before it happens.
Fairfield Processing, the manufacturer known for its Poly-Fil brand of synthetic stuffing material, will bring more than 100 jobs to St. Louis’ North Riverfront neighborhood. Wednesday’s announcement came after the manufacturer moved its facility from Granite City to St. Louis last summer. The relocation brought 50 full-time jobs with it, but company officials said they plan to add another 100 jobs in the next five years. Fairfield’s President Jordan Young said the city of St. Louis is well-suited for the company due to its freighting and manufacturing needs. It’s also an added bonus, Young said, for its employees, many of whom are from the St. Louis area. “Our people were actually from St. Louis ... commuting across the river to work in our company in Illinois,” Young said. “When we determined that we needed to keep those people moving across the river and starting the company and building a new plant here in the city of St. Louis made the greatest sense of all.” The 300,000-square-foot facility at 6432 Prescott Ave. houses the company’s manufacturing and distribution spaces in one building. The Poly-Fil brand has its hand in the do-it-yourself market. It produces more than 400 products besides its fiberfill, including beads for stuffing into bean bag chairs, foams for cushions, pet beds, pillows and stuffed animals. Marissanne Lewis-Thompson | St. Louis Public Radio St. Louis Mayor Lyda Krewson tried out the product Wednesday, stuffing a massive teddy bear full of the fiberfill. Krewson said she welcomes the expansion of the manufacturer to the city. A half century ago, she said manufacturing jobs were widespread in the U.S. and now, the industry is seeing a resurgence throughout the nation and the city. “Manufacturing jobs are good jobs, and we want all of them that we can get right here in St. Louis,” Krewson said. “We have a great port here. We have rail. We have barge. We have truck transportation, and so we are ideally situated for a manufacturing expansion.” A joint effort between the St. Louis Economic Development Partnership, 2nd Ward Alderwoman Dionne Flowers, the St. Louis Development Corporation, SLATE and the Missouri Partnership worked to get the company to move to St. Louis The manufacturer currently has openings for some seasonal positions. Young said many of those workers become full-time employees. Follow Marissanne on Twitter: @marissanne2011
National Institute for Health and Clinical Excellence guidelines on preoperative tests: the use of routine preoperative tests for elective surgery. Clinical Guideline CG3 from the National Institute for Health and Clinical Excellence (NICE) makes recommendations on appropriate clinical practice in preoperative testing for elective surgery. Unfortunately, there is minimal evidence on which the guidelines could be based and therefore they were constructed on the basis of professional opinion. This resulted in the construction of a decision matrix of Byzantine complexity built on foundations of sand: surgical risk is estimated using an unvalidated ad hoc risk estimation method; anaesthetic risk is estimated using the American Society of Anesthesiologists (ASA) risk method that has been demonstrated to be incapable of generating consistent risk assessments. The resultant matrix may be suitable for use as a template for future research, but is extremely complex and inadequately rigorous for routine use.
be a(39). What is the third smallest value in 0.5, -0.36, -3, y? 0.5 Let t = 0.021 + 0.179. What is the biggest value in -4, -2, t? t Let d = -3.3 - 0.5. Let w = d + -1.2. What is the third biggest value in w, 1/6, 1? w Let m = 3.99 + -0.99. Let r = -8 + 5. Which is the second biggest value? (a) 2/15 (b) m (c) r a Let k = 0.376 - 0.176. Which is the biggest value? (a) 0.4 (b) k (c) 0.01 a Let d = -0.05 + 0.35. Let h = 3436.6 - 3437. What is the biggest value in -0.7, h, d, 0.4? 0.4 Let m = 1290 + -1293. Which is the third smallest value? (a) 3 (b) 5 (c) m b Let f = -1567.1 + 1567. Let k = -5 + 3. Let c be ((-17)/(-7) + -2)*1. What is the second smallest value in f, c, k? f Let i = 0.1 + 3.7. Let q = 0.2 + i. What is the third smallest value in -0.1, q, 0.02? q Let l = 45.1 - 47. Let y = -0.023 + 2.223. Let k = y + l. Which is the smallest value? (a) -0.1 (b) k (c) -3 c Let f = 38 - 14. Let i = f + -29. Which is the second smallest value? (a) i (b) -2 (c) -2/13 b Let r = -166 - -174. What is the biggest value in r, 0.3, 0.06, -2/13? r Let s = 383/205 - 11/41. What is the third smallest value in s, -4, 1? s Let m = -1209434/22565 - 10/4513. Let u = m + 54. Which is the second biggest value? (a) -3 (b) u (c) 2 b Let x = -501/4 - -124. Which is the biggest value? (a) x (b) 5 (c) 3/2 (d) -0.04 b Let u = 466.3 + -463.3. Let q = 3.2 + -0.2. Let y = -3.5 + q. Which is the second biggest value? (a) 0.2 (b) u (c) y a Let p = -1373 + 1372.4. Which is the second biggest value? (a) 0.13 (b) -0.3 (c) p b Let q = -4.9856 + -0.0144. Which is the fourth biggest value? (a) 16 (b) q (c) -2/3 (d) -3/4 b Let v be 4/11*66/108. Suppose 9*m - 4*m = 4*o + 19, 5*o + 31 = -m. Let p(b) = -b - 5. Let n be p(o). What is the smallest value in 2, v, n? v Let u = 2.6 - 3. Let n = -1/1029 - 1025/4116. Which is the third biggest value? (a) u (b) n (c) -5 c Let t = -141 - -119.7. Let u = t + 21. Suppose -2*g = g + 12. Which is the second smallest value? (a) u (b) 0.2 (c) g a Let s(r) = r - 3. Let j be s(4). Suppose 3*d - 22 + j = -3*v, 5*d = 2*v + 28. Suppose d*i = 9*i + 6. Which is the biggest value? (a) -4 (b) i (c) 0.2 c Let s be -4 - (1 - 1 - (-84)/(-18)). Let w be (0 + -1)*1/7. Which is the third smallest value? (a) w (b) s (c) 12/5 c Let l = -3 + 7. Let c = 1991/7 + -284. What is the third smallest value in l, 2, c? l Let r(m) = m + 25. Let s be r(-8). Suppose 0 = 3*i + 4*p - s, -p = 4*i - 3 + 2. What is the third biggest value in i, 4/7, -2/5? i Let j be 18/16*(-10)/(-15). Suppose 3*a - 2*r = 5*a - 16, r + 17 = 4*a. What is the smallest value in j, a, 0, -2/15? -2/15 Let q = -529 - -533. Which is the biggest value? (a) q (b) -0.029 (c) -0.1 (d) -1/4 a Let r = -379.03 - -449.7. Let p = r - 71. Let y = p + -0.07. Which is the third smallest value? (a) y (b) 3 (c) -0.5 b Let n = 7 + -6. Let o be 334/(-8) + n/(-4). Let a be 4/o*(-7 + 4). What is the second smallest value in -1, a, 0? 0 Suppose 0 = -4*p, 3*y - 3 = 3*p - 2*p. Which is the fourth smallest value? (a) -0.4 (b) y (c) -2/3 (d) 0.1 b Let c = 3.02 + -1.42. Let y = 4.5 - 3. Let t = c - y. What is the second smallest value in t, 5, 0? t Let q = -91 + 91.224. Let i = q + 0.076. Let f = 12 - 7. What is the third biggest value in -0.4, i, f? -0.4 Let n = -2.92 + -0.08. Let v = 6 + n. Let g be (9/10)/(-5*(-6)/(-25)). Which is the smallest value? (a) v (b) 2/9 (c) g c Suppose 2*f = -2*n + 26, 0 = -3*n - 18*f + 17*f + 35. Which is the smallest value? (a) -4 (b) -1/19 (c) n a Let v be ((-5)/(-1))/(5/2). Let d be (v/(-20))/((-69)/18 + 4). Let s = 1 - 0.6. What is the biggest value in s, d, -1/3? s Let g = -8 - -7.4. Let q = g - -1. Let v = -7/11 - -39/44. Which is the second biggest value? (a) v (b) q (c) -5/6 a Let f be (-3)/(-6) + (-3)/2. Which is the second biggest value? (a) 196 (b) -3 (c) f c Let l = -19/39 + 2/13. Let p be -25*((-4)/(-70) + (-1)/(-7)). What is the biggest value in l, 1/2, p, 0? 1/2 Let q = 25 + -24.7. Let g = q + 10.7. Which is the third smallest value? (a) -2 (b) g (c) -0.3 b Let p = 23/5 + -133/30. Let a = -0.08 + -1.12. Let t = a - -1.2. What is the second biggest value in p, t, 3? p Let p = 0.188 - 0.488. Let g be 0/(-2) + -1 + 4. Let i = -8 + 5. What is the biggest value in p, g, i? g Let w = 38 - 65. Let o = w + 36. Which is the third biggest value? (a) 0.3 (b) o (c) 2 a Let k = 4 - 3.5. Let s be ((-3)/387)/(11/(-236)). Let h = s + 2/129. What is the smallest value in k, 0.1, h? 0.1 Let m = -0.239 - 11.861. Let y = m + 12. Let g = -0.8 + 0.3. What is the biggest value in 1, g, y? 1 Suppose f = -4*f + w + 896, 5*w = -3*f + 560. Let h be 3*16/f*-3. Which is the third smallest value? (a) h (b) -0.5 (c) 1 (d) -3 b Let x = -0.03 - -0.08. Let k = -2.05 + x. Let i = k + 1.4. Which is the smallest value? (a) -1 (b) i (c) -4 c Let n be 1/3 - (31 - 31). What is the fourth smallest value in -0.5, 0, 1/9, n? n Let p = -0.41 + -0.09. Let v = -0.2 + 0.37. Let q = v - 5.17. What is the third smallest value in p, q, 0.1? 0.1 Let q = -1489/2 + 743. What is the smallest value in -0.4, q, 39? q Suppose 29 = -4*v - 3*p, -2*p = 4*v + 2 + 24. Let q = -8/1071 + -4244/5355. Which is the third smallest value? (a) 1/4 (b) q (c) v a Suppose i = 2*r - 18, r = -2*r - 5*i + 27. Let g = -5 - r. Let s be 217/49 + (-8)/g. Which is the smallest value? (a) s (b) -4 (c) -6/11 b Let h = 7.59 + 4.41. Which is the third biggest value? (a) h (b) -0.3 (c) 6 b Let n = 7.2 + -7.2. Which is the third biggest value? (a) -4 (b) -0.124 (c) 1 (d) n b Let k be (-1)/2 + 159/6. Let w = -26 + k. Suppose r + 2*s - 3 = w, 5*s - 5 = r + 6. Which is the second smallest value? (a) r (b) 0.04 (c) 0.3 b Let j = -4 + 6. Let d = -0.052 + -0.018. Let q = d - 2.93. Which is the third smallest value? (a) q (b) j (c) -4/5 b Let b = -0.05 - -0.45. Let s = -80.984 + -0.016. Let v = -79 - s. What is the second smallest value in v, -0.3, b? b Let r = 495.4 + -495. What is the third biggest value in -5/2, r, -2/9, 0.3? -2/9 Let p = 1584 - 1608. What is the fourth biggest value in p, 1, -4, 3? p Let a be (-108)/9*1/(-3). Let g = 6.08 - 5.83. What is the third biggest value in -2, a, -0.4, g? -0.4 Let g = -804 - -659. Which is the second biggest value? (a) -0.3 (b) 1/2 (c) g (d) 0 d Let c = 0.6 + -2.6. Let s = -112 - -80. Let b = s + 29. What is the biggest value in c, b, 1/7? 1/7 Let q = -2/7 + 31/35. Let i = -2.137 - -0.137. What is the third biggest value in i, q, -4? -4 Suppose -3*o + s - 91 = 128, -69 = o + s. Let v = o + 76. What is the biggest value in 3/7, 1, v? v Let l be 1*7*(-8)/(-28). Which is the second smallest value? (a) 0.2 (b) l (c) -0.2 (d) -0.1 d Let x be -2 + (-341)/(-330)*2. Which is the third biggest value? (a) -3 (b) -5 (c) x b Suppose 0 = -0*s + 7*s + 28. Let j = s + 4. What is the second smallest value in -5, -1/7, j? -1/7 Suppose -2*u + 13 + 3 = 4*b, 5*u + 20 = 5*b. Let k = 56 - 52. Suppose -m - k = -u. What is the second smallest value in 5, m, -1/6? -1/6 Let j = -43/5 - -8. Let y = 5.36 + -5.46. Let b be -2 + (1 - -1*11). What is the second biggest value in j, b, y? y Let m = -48.21 + 48. Let w = 7.79 - m. Let o = -0.5 - 4.5. What is the third biggest value in 4/3, w, o? o Suppose 2*l + 17 = 4*x + 5, -3*x = -3*l - 12. Suppose 0 = m - x + 5. Which is the biggest value? (a) m (b) 2/7 (c) 8 c Let d = 1080.01 - 1075. Let k = 0.01 - d. Let s = -113 - -113.02. What is the biggest value in -0.1, s, k? s Let v(y) = -y + 3. Let f be ((-21)/(-6))/(2/4). Let q be 44/6 + f/(-21). Let p be v(q). Which is the second biggest value? (a) p (b) -2/17 (c) 2/15 b Let i be 40/(-10) + 78/19. Let y = 1 + 0. What is the third biggest value in i, y, 1/2? i Let k be 2/(-6) + 1*(-3)/(-3). What is the third smallest value in -15, -4, -3, k? -3 Let o(h) = -3*h - 10. Let y be (-3 - 55/(-15))*-6. Let n be o(y). Let j = -0.3 + 0.2. Which is the biggest value? (a) n (b) j (c) 3/2 a Let q = -13/38 + 93/494. Let z = 59/78 - 12/13. What is the second smallest value in 2, q, z? q Let f = -40 - -45. Suppose -2*k + f - 3 = -2*l, 0 = -5*k - 5*l + 15. What is the second biggest value in -2, -3/4, k, 6? k Let y be (12 - 9)*3*5/60. Let j = -52 - -313/6. What is t
Psych (season 7) The seventh season of Psych, containing 14 episodes, premiered on the USA Network in the United States on February 27, 2013. The primary run ended on May 29, 2013, but a television special, Psych: The Musical aired later in the year. James Roday, Dulé Hill, Timothy Omundson, Maggie Lawson, Corbin Bernsen, and Kirsten Nelson all reprised their roles as the main characters in the series. Production Steve Franks continued as showrunner of the series. The song "I Know, You Know", performed by The Friendly Indians, continued to be used as the theme song for the show. Psych was renewed for its seventh season on January 10, 2012. On April 6, 2012, Dulé Hill tweeted that filming for the season was to begin on April 23, 2012. The previously announced musical episode, originally thought to be part of the sixth season, aired during the seventh as a two-hour event in December 2013. However, the episode was intended to occur in the middle of the season, and it suffers several continuity errors as a result. The season also contains episodes inspired by Clue and The Blair Witch Project; the Clue-based episode aired as the series' 100th. Cast James Roday continued to portray the fake psychic detective Shawn Spencer. Dulé Hill appeared as Burton "Gus" Guster. Timothy Omundson and Maggie Lawson portrayed detectives Carlton "Lassie" Lassiter and Juliet "Jules" O'Hara, respectively. Corbin Bernsen continued as Henry Spencer, and Kirsten Nelson returns as SBPD Chief Karen Vick. Kurt Fuller and Sage Brocklebank reprised their recurring roles as Woody the Coroner and Officer Buzz McNab, respectively. Ally Sheedy is set to return to the series in the musical episode as Mr. Yang; also appearing in the episode will be Barry Bostwick, Brooke Lyons, and Anthony Rapp. Cybill Shepherd returned as Madeleine Spencer, Shawn's mother, while Kristy Swanson continued to portray Marlowe Viccellio, Lassiter's convict girlfriend (who is released and married to Lassiter during season seven). Max Gail, Arden Myrin, and Jerry Wasserman returned in the premiere, titled "Santabarbaratown 2", reprising their roles of Henry's shooter, stalker, and the shooter's accomplice, respectively, from the sixth season. Christopher Lloyd, Lesley Ann Warren, and Martin Mull, all of whom appeared in the original Clue film, appeared in Psychs 100th episode; also appearing in the episode, titled "100 Clues," were Curt Smith of Tears for Fears and Garrett Morris, filling Tim Curry's role from Clue. Parminder Nagra appeared in a recurring role as Rachael, a beautiful and charming woman for whom Gus falls; she is later revealed to be a single mother. Jeffrey Tambor appears in two episodes as Juliet's step-father, Lloyd French. Anthony Michael Hall appears as Harris Trout, a consultant hired by the mayor to increase efficiency at the SBPD. Other guest stars for the season included The Big Show, Garcelle Beauvais, Rachel Blanchard, John Kapelos, David Koechner, Lori Loughlin, Katy Mixon and Joey Slotnick. Episodes DVD release Psych: The Complete Seventh Season, consisting of 14 episodes, was released on DVD on October 8, 2013. The three-disc set is presented in anamorphic widescreen format, English Dolby Digital 5.1 surround sound, and with English subtitles. The bonus features of the set include a director's cut of the episode "100 Clues", deleted scenes; a gag reel, five video podcasts featuring producers, writers, and directors, and "Psychouts." The entire running time for the set is 10 hours, 13 minutes. The episode "Psych: The Musical" was released separately on DVD on December 17, 2013, just two days after airing. Notes † denotes a two-hour episode (with advertisements). References Category:Psych Category:2013 American television seasons
In recent years, there has been an increasing demand for saving energy of various air conditioning apparatus forming an air-conditioning system installed in, for example, buildings. To meet this demand, there have been many proposals for an air-conditioning system control apparatus configured to reduce the power of an air-conditioning apparatus. In addition to reduced energy consumption, the thermal perception of a person in a room, or so-called comfort level, also needs to be satisfied, and hence an air-conditioning system control apparatus for achieving both reduced energy consumption and a satisfactory comfort level has also been proposed. Hitherto, many air-conditioning system control apparatus have been configured to control operation of an air-conditioning apparatus so that an indoor temperature and humidity are each within a comfortable range based on information on the indoor temperature and humidity, operating data of the air-conditioning apparatus, and other information. For example, a method exists for determining a control target value based on a thermal environment evaluation index, such as a predicted mean vote (PMV, defined by ISO 7730 in 1987) (refer to Patent Literature 1). Further, there is also a method of controlling an air-conditioning apparatus so that the indoor temperature and humidity are each within a comfortable range by estimating the indoor temperature and humidity based on an outside air discomfort index determined based on the outside air temperature and the outside air relative humidity (refer to Patent Literature 2).
Q: Battery level monitoring circuits I want to use a USB power bank for powering my RPi3B but I need to display how much charge is left. What is a good set up of measuring the battery level of the power bank? A: USB power banks vary, but mostly they will have a single 3.7V cell and a boost converter to bring that up to 5V. The cell will be charged to, say, 4.2V and decrease to, say, 3.1V. The boost converter takes this varying voltage and boosts it up to 5V for use by USB devices. The power level is a function of the voltage of the cell. The output voltage will stay the same regardless until the cell is discharged and it shuts off. Unless you take the power bank apart you won't be able to measure the cell voltage from the output. Some power banks do have a few LEDs to indicate level, so you might be able to interface with those, or if you want something more accurate use an ADC (analog to digital converter) to measure the cell voltage. If you've gone that far, you might be better off just using the cell and finding something like a lipo shim rather than designing your own circuit (I don't know off-hand of any that do give more than a simple low battery warning).
Nashik traders' strike adds to onion woes Nashik, Jan 10 (Agencies): Onion traders in the district on Sunday decided not to purchase onions for two days—Monday and Tuesday—from Agricultural Produce Market Committees (APMC) to protest the State Government's directive that onions should not sell over Rs 40 per kg. Nashik District Onion Traders Association at its meeting held at Umrane took this decision, said Suresh Parikh, onion trader. "We have been buying onions at Rs 30-45 per kg from APMC, and we have to bear losses because of the Government directive," he said. Income tax department on Saturday raided houses and godowns of four onion traders—two in Lasalgaon and one each at Nashik and Pimpalgaon, but did not find evidence of onion-hoarding, Parikh claimed. After two days' week-end closure, APMC will open on Monday, and auctions of fresh incoming stocks would be held.
Evidence for a role of D1 dopamine receptors in d-amphetamine's effect on timing behaviour in the free-operant psychophysical procedure. Temporal differentiation of operant behaviour is sensitive to dopaminergic manipulations. Studies using the fixed-interval peak procedure implicated D2 dopamine receptors in these effects. Less is known about the effects of dopaminergic manipulations on temporal differentiation in other timing schedules. To examine the effects of a D1 antagonist,8-bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol (SKF-83566), and a D2 antagonist, haloperidol, on performance on the free-operant psychophysical procedure, and the ability of these antagonists to reverse the effects of the catecholamine-releasing agent, d-amphetamine on performance. The antagonists' ability to reverse d-amphetamine-induced hyperlocomotion was also examined. Rats responded on two levers (A and B) under a free-operant psychophysical schedule, in which reinforcement was provided intermittently for responding on A during the first half, and B during the second half, of 50-s trials. Logistic functions were fitted to the relative response rate data (percent responding on B [%B] vs time [t]) in each treatment condition, and quantitative timing indices [T50 (value of t corresponding to %B=50) and Weber fraction] were compared among treatments. Effects of the treatments on locomotion were measured in a separate experiment. SKF-83566 (0.015, 0.03, 0.06 mg kg(-1)) did not affect timing performance. Haloperidol (0.025, 0.05 mg kg(-1)) had no effect; a higher dose (0.1 mg kg(-1)) reduced T (50). d-Amphetamine (0.4 mg kg(-1)) reduced T50; this effect was antagonised by SKF-83566 but not by haloperidol. Both antagonists reduced d-amphetamine-induced hyperlocomotion. The results suggest that d-amphetamine's effect on performance in the free-operant psychophysical procedure is mediated by D1 rather than D2 receptors.
Claims on contested holdings in Cuba - bootload http://www.slate.com/articles/news_and_politics/foreigners/2015/11/u_s_claims_in_cuba_the_strange_battle_that_is_exciting_speculators_and_could.html ====== refurb Wow, this guy's bias is really showing. _Young Cubans—well-educated and healthy, thanks to the communist system—comprise an attractive workforce._ _The scent of predatory capitalism wafted through the air._ It's amazing how some people will completely ignore a brutal dictatorship if other things align with their agenda. ~~~ brownbat Hitchens talks in "Letters to a Young Contrarian" about being a young communist, and actually working with some of those forming the government in Cuba. They said, "our revolution will be different, our people will be free. We will even allow satire, on all but one topic." Hitchens: "Oh? What topic is that?" Communists: "Why, the government, of course!" Thus began his disillusionment... ~~~ kentrado A communist government is a bit like an anarchist government, innit?
Starship Entertainment has announced that MONSTA X’s Wonho will be unable to perform at the Malaysia leg of the group’s world tour. However, he has made the decision to still be in Malaysia to greet fans who have waited for the concert. On June 22, the agency posted a notice regarding the issue and their statement reads as follows: Hello, this is Starship Entertainment. First, we would like to apologize to all fans as MONSTA X’s member Wonho will not be able to perform at the “2019 MONSTA X World Tour ‘We Are Here'” concert in Kuala Lumpur. On June 21, MONSTA X flew to Malaysia for their world tour and when they arrived at the airport there, Wonho was unable to enter the country because he could not locate his passport. Wonho then returned to Korea, was issued an emergency passport, and tried to catch the fastest flight back to Malaysia so he could perform at the concert, but we have come to the conclusion that it will be difficult for him to participate in the concert and the event that will follow the concert. However, our agency and Wonho have both agreed that though he will not be able to participate in the concert, Wonho will still return to Malaysia for all the fans who have waited for him, and he is currently waiting to fly out. We sincerely apologize for causing concern to all fans who have been anticipating and waiting for this event. We will make sure something like this does not happen again in future concerts of the world tour. Thank you.
Pages Tuesday, 20 January 2015 LOVING: Nutribullet - A Review A Nutribullet is for life, not just for Christmas.I genuinely cannot get enough of it and can't stop telling people HOW GOOD IT IS!Not a juicer, not a blender but an extractor - it breaks down the ingredients leaving the most nutritious value.With 12 pieces to it, it proves very versatile (I even milled cashew nuts this week to use to make pesto using the milling blade!)With my first attempt (shown below) I used the tall cup to make my drink (fruit and veg is crushed using the extractor blade) HOWEVER, unless making for two or three people, I would definitely recommend using the short cups daily as it makes just the right amount.Not only is it easy to use, it's also compact and ridiculously easy to clean. I can come downstairs at 8am, make my smoothie and have the blade cleaned by 8.05! I LOVE this because so many juicers and blenders I've used in the past are an absolute pain in the arse to clean so it meant I would use them at weekends only, whereas this is practical for daily use! As well as getting the pocket nutrition guide - filled with recipes (not just juices/smoothies - soups, dips, allsorts!) you get this A4 starter recipes sheet - perfect to get you going with your first uses of the Nutribullet. For my first juice, I went for the Toxic Cleansing Blast - spinach, pineapple, pear, apple, banana and water. De-pip the apple and pear, peal the banana, throw in a cup of chopped pineapple, a couple of handfuls of spinach and fill to the max line - this is for the large cup, I would definitely half and use the small cup if just making for yourself, unless you want to save the other half for the following day. To pop it on the blender, attach the extractor blade to the tall cup (or small, if that's what you're using), tip upside down (ONLY if you've put the blade on - I'm stupid enough to not do this and spill it everywhere!) and press down whilst twisting so the cup pushes down and it will start extracting. Not the most appetising looking juice but green juices are so good for you! There's even an app. NutriLiving - which is perfect if you're too lazy to try and find inspiration in the recipe/lifestyle booklet - you can also select a few ingredients and it'll throw up a few recipes for you - ideal to quickly find ideas of how to use up your fruit and veggies in the fridge! Deliciously Ella and Madeleine Shaw are also great for juice inspiration - Ella has her own app now too! This week I've been having mixed berry, grape and pineapple with water - so yummy! I'm going to branch out soon and have kale as well as trying one of the recipes from the Pocket Nutrition Guide (possibly a dip as I cannot get enough of hummus and carrot sticks at the moment!) Cannot recommend the Nutribullet enough - I cannot believe I did get one sooner!
It was all in front of Gruden Saturday, another team, another season and another chance to alter those widely varied perceptions of him. For Gruden, and for the Bucs, this is where the 2008 season starts, on the freshly mowed grass of a team's first practice. It was a miserable morning, so hot that the birds flying past smelled like lunchtime at Ya-Ya's, but Gruden seemed happy in his tasks. For a football coach, there is no finer place to be than on a field. As Gruden bounded around the field, wading through the drills, barking at the mistakes, you could not help but notice that, even after all this time, his energy has not faded. This was the sight of a man in his element. Outside the lines, there are rumors and questions, controversies and criticism. Inside, there is football, and the sight of a team taking the first steps of a seasonlong journey. When it is over, who knows what you will think of Gruden. Just a guess, but it will probably have something to do with the team's final record. When it comes to Gruden, of course, opinions seem to fluctuate. Over his time in Tampa Bay, Gruden has been the favorite son and the disappointing guru, the conquering hero and the one to blame. He has been slapped on the shoulder, and he has had his feet held to the fire. This is Gruden's seventh season here (his 11th as an NFL head coach), and as such, there has been a lot of time for a lot of very strong opinions about him to form. In his six previous seasons, three have ended with a division title, and three have ended with a losing record. Given that, it's fair to say that no one is going to agree on Gruden until there is a little more year-to-year consistency. The search for that began Saturday, too. "I like this team," said Gruden, who turns 45 on Aug. 17. "I really do. You go through our meeting rooms, and you see Warrick Dunn with our running backs, and you see Jeff Garcia working with our young quarterbacks, and you see Joey Galloway and Ike Hilliard with our wide receivers. You see Kevin Carter working with the defensive linemen and Derrick Brooks with the linebackers and Ronde Barber with the secondary. "I'm charged up over taking another run at this. Hopefully, we can have a lot of fun." For Gruden, the feel has to be different than a year ago, when the world seemed to be measuring the size of his neck. Coming off a 4-12 season, Gruden was one of the coaches thought to be in danger of losing his job. This year? A recent poll had a dozen NFL coaches listed as being more at risk than Gruden. That's what a playoff spot, and a new contract, will do for a coach. Gruden seems to understand. On Friday, when all the chatter was going on about Brett Favre, someone asked him how Garcia was responding to the reports. Gruden paused. Then he grinned and said, "Bill Cowher is out there, too." In other words, there is pressure on everyone. "Sometimes, heat and pressure is a good thing," Gruden said. Ah, you say. But this year, there isn't a lot of heat on Gruden. "I put it on myself," he said. "I consider this job to be a great responsibility." He has been at it for a while now. Only Denver's Mike Shanahan, New England's Bill Belichick, Tennessee's Jeff Fisher, Philadelphia's Andy Reid and Seattle's Mike Holmgren have been with their current team longer than Gruden. Yeah, he has changed some over the years. "I've probably changed a lot," Gruden said. "I've learned a lot. You can't do this for a period of time and not let your experiences teach you. There have been a lot of experiences and a lot of changes. That's life. You can't stay the same and survive. You can't have a car that runs 4-5 miles to the gallon unless you've got a lot of money to spend on gas. Times change. You have to adjust." General manager Bruce Allen describes Gruden like this: "You ask people what you would do if you couldn't do what you are doing now. Jon would say, 'Coach.' And you would say, 'No, you're already a coach. What else?' And Jon would say, 'The coach of another sport.' "That's Jon. He loves being a coach." For Gruden, the heavy work began Saturday. This year, you would like to see Gruden's offense be more productive. You would like to see his young players realize the potential they have flashed. You would like to see a second good season in a row. DE Gaines Adams changes his diet and shapes up for his second NFL season. 6C Bucs training camp updates Get the most up-to-date news in our Bucs blog. Stay on top of the latest developments with our daily midday audio slide shows featuring photos from camp and insights from Times staff writers Rick Stroud, Stephen F. Holder and Tom Jones at bucs.tampabay.com.
Affiliations The Columbia Center for Children's Environmental Health, Columbia University Mailman School of Public Health, New York, New York, United States of America, Division of Pulmonary, Allergy and Critical Care Medicine, Columbia University College of Physicians and Surgeons, New York, New York, United States of America Affiliations Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, United States of America, Center for Environmental Genetics, University of Cincinnati, Cincinnati, Ohio, United States of America, Cancer Center, College of Medicine, University of Cincinnati, Cincinnati, Ohio, United States of America Figures Abstract In a longitudinal cohort of ∼700 children in New York City, the prevalence of asthma (>25%) is among the highest in the US. This high risk may in part be caused by transplacental exposure to traffic-related polycyclic aromatic hydrocarbons (PAHs) but biomarkers informative of PAH-asthma relationships is lacking. We here hypothesized that epigenetic marks associated with transplacental PAH exposure and/or childhood asthma risk could be identified in fetal tissues. Mothers completed personal prenatal air monitoring for PAH exposure determination. Methylation sensitive restriction fingerprinting was used to analyze umbilical cord white blood cell (UCWBC) DNA of 20 cohort children. Over 30 DNA sequences were identified whose methylation status was dependent on the level of maternal PAH exposure. Six sequences were found to be homologous to known genes having one or more 5′-CpG island(s) (5′-CGI). Of these, acyl-CoA synthetase long-chain family member 3 (ACSL3) exhibited the highest concordance between the extent of methylation of its 5′-CGI in UCWBCs and the level of gene expression in matched fetal placental tissues in the initial 20 cohort children. ACSL3 was therefore chosen for further investigation in a larger sample of 56 cohort children. Methylation of the ACSL3 5′-CGI was found to be significantly associated with maternal airborne PAH exposure exceeding 2.41 ng/m3 (OR = 13.8; p<0.001; sensitivity = 75%; specificity = 82%) and with a parental report of asthma symptoms in children prior to age 5 (OR = 3.9; p<0.05). Thus, if validated, methylated ACSL3 5′CGI in UCWBC DNA may be a surrogate endpoint for transplacental PAH exposure and/or a potential biomarker for environmentally-related asthma. This exploratory report provides a new blueprint for the discovery of epigenetic biomarkers relevant to other exposure assessments and/or investigations of exposure-disease relationships in birth cohorts. The results support the emerging theory of early origins of later life disease development. Funding: This work is in part supported by National Institutes of Health grants: ES009600 (FP), ES008977 (FP), ES015905 (FP, SMH, RM, DT), ES013071 (SMH), ES015584 (SMH), and ES006096 (SMH), ES016817 (WYT), the Department of Defense award DAMD W81XWH-06-1-0373 (WYT), the U.S. Environmental Protection Agency award RD-832141(FP), and the New York Community Trust (FP,RM, DT, JH). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing interests: The authors have declared that no competing interests exist. Introduction Asthma is the most common chronic childhood disease [1] and its risk may be strongly influenced by prenatal events [2]. Low income communities experience some of the highest childhood asthma rates in the U.S [3] and new preventive strategies are lacking due in part to the absence of predictive biomarkers. In our longitudinal cohort study of children residing in urban low-income, minority communities of New York City [4]–[6] the asthma rate exceeds 25% and is among the highest in the nation. Preliminary evidence suggests that transplacental exposure to polycyclic aromatic hydrocarbons (PAHs) derived largely from traffic-related air pollutants may be a risk factor for the early development of asthma-related symptoms in this cohort [5]. However, we could not rule out the possibility that postnatal exposure of children in this cohort to these pollutants may also contribute to the symptoms without additional studies. According to the hypothesis of the early origins of chronic disease, exposure to agents that are transmissible from mother to fetus has profound influences on the functional capacity and performance of many organs/tissues later in life [7]–[11]. Developmental plasticity allows the fetus to make anticipatory responses to the external environment by altering the course of cellular and organ differentiation in utero in order to gain adaptive advantages for later life challenges. However, a pronounced mismatch between “anticipatory adaptations” made during early life and demands in later life could be a cause of disease [10]. More importantly, environmental insults could “mislead” early organogenesis resulting in serious ailments in later life. The best studied mechanisms underpinning the latter scenario is the induction of aberrant DNA methylation of regulatory sequences in susceptible genes by environmental toxicants during critical developmental periods, leading to inappropriate gene expression and disease pathogenesis in later life [12]–[16]. This body of research suggests that transplacental exposure to high levels of airborne PAHs could cause aberrant DNA methylation changes, leading to dysregulation of gene expression and perhaps childhood asthma. These alterations could occur, not only in target organs/tissues such as fetal lung or the immune system [11], but also in peripheral tissues such as fetal circulating white blood cells and placental tissues, thus providing opportunities to discover and develop highly sensitive and specific, minimally invasive biomarkers for exposure assessments or clinical indications [17]. The primary objective of this study was to explore whether transplacental exposure to PAHs in humans induces epigenetic reprogramming involving aberrant DNA methylation of specific genes that might be mechanistically related to childhood asthma or airway inflammation. Study subjects were children born to nonsmoking Dominican and African American women living in Northern Manhattan and the South Bronx. They were participants in the Columbia Center for Children's Environmental Health (CCCEH) cohort study previously described [4]–[6]. Mothers completed prenatal air monitoring and donated a maternal and/or umbilical cord blood sample and, in some cases, fetal placental tissue (FPT) at delivery. Umbilical cord white blood cells (UCWBC) and matched FPT from 20 cohort subjects were used initially for candidate identification and selection, as it is not feasible to obtain lung/immune cells in newborns. UCWBC provide a reasonable surrogate for our target organ/tissue (lung/immune cells) because they contain stem cells that can populate the lungs in later life and also provide a rich source of T cells [18] which are important producers of cytokines and other asthma mediators. The matched FPT provides ample tissue for obtaining fetal RNA to verify correlative changes in gene expression. A larger sample of 56 cohort subjects was used to validate the markers identified. Methylation of a 5′-CpG island (CGI) in acyl-CoA synthetase long-chain family member 3 (ACSL3) was found to be positively and significantly associated with the level of maternal PAH exposure and with a parental report of asthma symptoms prior to age 5 in this exploratory study. Results Identification of candidate genes and selecting the most relevant candidate Figure 1 shows the work flow used in the discovery of candidates and strategies employed for selecting candidate genes associated with prenatal airborne PAH exposure and with asthma. Figure 1. The workflow chart outlines how to discover the methylated genes in a step-by-step manner. Initially, ten umbilical cord white blood cell (UCWBC) samples from children with maternal (prenatal) PAH exposure above and ten with prenatal exposure below the cohort median were selected irrespective of gender and ethnicity. DNA was isolated from the sample was dichotomized according to the median of prenatal PAH exposure obtained from 48-hour personal air monitoring of the mothers during pregnancy (the cohort median is 2.3 ng/m3). Candidates with differentially methylation status between the samples from the two groups were discovered by Methylation Sensitive Restriction Fingerprinting (MSRF) following by subcloning and sequencing. Candidates were further identified by in silico analysis from databases from NCBI and UCSF genomic centre. Candidates which contained CpG island (CGI; CG rich region with >60% GC content and obs/exp ratio >0.6) on its 5′ flanking region were chosen for bisulfite sequencing to confirm the dependency of the methylation status of the CGI in a candidate gene on maternal PAH exposure. Six genes confirmed to have the latter relation were subjected to gene expression analysis in the 14 matched fetal placental tissues (FPT). The ACSL3 was found to have the highest concordance between degree of CGI methylation and level of gene expression in reverse manner. It was therefore selected for the final analyses for correlation between methylation status of its CGI and transplacental PAH exposure and/or parent reported asthma symptoms of childhood asthma up to age 5 in a case-control study comprised of 56 participants. For this part of the study, Methylation specific-PCR (MSPCR) protocol was optimized to analyze the methylation status of R1 in Figure 4A was used as the high throughput method to analyze this larger sample set. The CGI(s) (shaded in blue in the genomic DNA sequence) were identified in silico based on a CG content >60%, with an observed/expected ratio of 0.6 according to instructions from MethPrimer. TSS: Transcription start site. The nested PCR-amplified region was indicated by a line with double arrow heads and methylation status of this region was determined by bisulfite genomic sequencing. We next determined the strength of the relationship between the percent of methylation of a candidate gene's 5′-CGI in UCWBC DNA samples and its transcript expression level in matched FPT RNA samples (Table 2 and 3). The degree of methylation of a region encompassing the entire predicted 5′-CGI for each candidate gene was determined by bisulfite sequencing (Figure 2, the location of the amplicon was marked as BSPCR) and mRNA levels determined by real time RT-PCR. The percentage of promoter methylation (Met%) determined by bisulfite sequencing and relative gene expression levels (RER) determined by real time RT-PCR of all six candidates tested on 14 paired UCWBC DNA and FPT RNA samples are presented in Table 2. The degree of concordance between these two parameters for each candidate is shown in Table 3. We found that the degree of ACSL3 5′-CGI methylation and the level ACSL3 transcript expression exhibited the expected inverse relationship with the highest concordance and significance (τ = −0.45; p<0.01) when compared to the other candidates. These findings indicate that the ACSL3 5′-CGI is likely a regulatory CGI since increased cytosine methylation in this sequence in UCWBC DNA samples was found to be significantly associated with transcriptional silencing of the gene in matched FPTs. To further demonstrate that the methylation status of the ACSL3 promoter affects gene expression, we used a lung non-small carcinoma cell line H1299 as a model system. Two series of experiments were performed. In the first series, we treated H1299 cells with a DNA demethylation agent, 5-aza-2′-deoxycytidine (5-aza-dC), and found that ACSL3 expression was significantly increased (Figure 3A) along with promoter demethylation (data not shown). These data provide evidence that demethylation of the ACSL3 promoter is associated with enhancement of gene expression. In the second series of experiments, H1299 cells exposed to low doses of benzo[a]pyrene (BaP; 0.01 to 1 nM), a representative PAH, showed a dose-dependent decrease in ACSL3 transcript expression as indicated by real time RT-PCR analysis (Figure 3B) and increased promoter hypermethylation as revealed by bisulfite sequencing (Figure 3C). These data strongly support the notion that the CpG island in the ACSL3 promoter plays a regulatory role in gene expression. A: Cells were treated with 0.5 and 1.0 µM 5-AZA-dC with DMSO as control every 2 days for a total of 8 days. B: Cells were treated with 0.01, 0.1 and 1.0 nM BaP with DMSO as control every 2 days for a total of 4 days. RNA was isolated, reverse transcribed and underwent real-time PCR. The 2-ΔΔCt method was used to calculate the relative expression level of transcripts normalized to β-actin. *Statistically significant differences between exposed and control was accepted at p<0.05. C: Diagram represents methylation status of ACSL3 promoter of H1299 cells exposed to BaP assayed by bisulfite genomic sequencing. Cells were treated with 0.01, 0.1 and 1.0 nM BaP with DMSO as control every 2 days for a total of 4 days. Open circle: unmethylated CG; closed circle: methylated CG. Putative transcription factor binding sites such as Sp1, AP2, GCF, c-fos and junB are shown in scale with the particular CG sites on the promoter. Association of methylation status of ACSL3 5′CGI with PAH exposure in the larger sample ACSL3 was chosen for subsequent assessment of the relationships between prenatal PAH exposure and gene 5′-CGI methylation status and for exploratory analyses of PAH exposure status and asthma classification in a larger sample of 56 children from the CCCEH cohort. The organization of the 5′-flanking sequence in the promoter region of ACSL3 is shown in Figure 4A. Before we conducted the full investigation on the larger sample of 56 children, the following quality control experiments were performed. First, bisulfite sequencing analyses of an amplicon encompassing the entire predicted ACSL3 5′-CGI (Figure 4A, BSPCR marks the amplicon) were performed on the 20 UWBC DNA samples; five from each of the high or low PAH groups with or without asthma. Bisulfite sequencing data (Figure 4B) showed that hypermethylation of this CGI was found to be strongly associated with maternal exposure to a PAH level higher than the cohort median of 2.3 ng/m3. Asthma status did not seem to affect methylation status of ACSL3 promoter. Second, based on bisulfite sequencing data, we designed and optimized three methylation-sensitive-PCR (MSPCR) protocols [27], [28] to amplify three regions (R1, R2 and R3) within the CGI that exhibited the greatest differential methylation changes between samples from the “high PAH” and the “low PAH” groups regardless of asthma status (Figure 4A, R1–3 are marked). These three regions were closely flanking the transcriptional start site (TSS). We further validated that the methylation status of R1 exhibited the strongest correlation with bisulfite sequencing data from analyses of the entire CGI. Representative data from MSPCR analyses of samples from children with prenatal PAH exposure above (high PAH) or below (low PAH) the cohort median are illustrated in Figure 4C. Thus, MSPCR of R1 was chosen as the high throughput method for investigating the methylation status of the ACSL3 5′-CGI in the larger sample comprised of 56 children. A) Schematic diagram of the CG content (%) in the 5′ flanking region of the ACSL3 gene. A CGI of 1058 bp was located at the 5′ end of ACSL3 including transcription start site (TSS), untranslated region (UTR) exon1 and intron 1. Individual CG sites are marked as red vertical lines in the genomic DNA sequence. The PCR-amplified regions were indicated by lines and methylation status of this region were determined by BSPCR and MSPCR. B) The diagram represents the methylation status of MSPCR-amplified regions (R1–R3) of 20 samples with high or low PAH exposure with or without asthma assayed by bisulfite genomic sequencing. 6 clones were sequenced from each sample. The PAH level of each sample is shown. Open circle: unmethylated CG; closed circle: methylated CG. MSPCR-primers were then specially designed on particular regions (R1–R3). Overall Met% of ACSL3 promoter is shown. Statistical difference was accepted at p<0.05* when compared with the group of low PAH without asthma. C) Representative results from MSPCR analyses on Region 1 (R1) of samples from the low and high PAH group. M: methylated; and U: unmethylated. The methylation status of ACSL3 5′-CGI of all samples was further analyzed by MS-PCR using the same sets of primers. Results are shown in Table 4 and Table 5. High PAH (≥ the cohort median of 2.3 ng/m3), Low PAH (<the cohort median). Point labels are values of PAH of each children. Statistical software, sas, was used for ROC plot and R was used for determination of cutoff value. The cutoff value corresponds to the desired sensitivity and specificity (or 1-specificity). Table 4 shows that 30 of the 56 children had a methylated ACSL3 5′-CGI; 81% of these 30 children were born to mothers with PAH exposure equal or exceeding 2.41 ng/m3, the cutpoint value determined by the ROC analysis. Thus, methylation was positively and significantly associated with maternal PAH exposure level. The odds ratio (OR) of having a methylated ACSL3 5′CGI in UCWBC DNA was 13.8, 95% CI = [3.8, 50.2] (p<0.001), given the maternal PAH exposure was ≥2.41 ng/m3, compared to those exposed to <2.41 ng/m3. ACSL3 5′CGI methylation status was not affected by gender or ethnicity. Discussion In this exploratory study, we have identified ACSL3 as a candidate biomarker/gene whose 5′-CGI methylation status appears to be related to transplacental PAH exposure and further associated with PAH-associated asthma. Thus, ACSL3 may be the first potential surrogate endpoint for environmentally related childhood asthma. If confirmed, such a biomarker holds promise in assessing PAH exposure and as a clinically relevant predictor for asthma risk in children born to mothers exposed to air pollutants such as traffic-related combustion emissions. We used a set of stringent criteria for the identification, selection and validation of candidates, which resulted in choosing ACSL3 the final candidate for the 56-sample study. We first used an unbiased method, MSRF, to identify both hypo- and hyper-methylated sequences in the high PAH group compared to the low PAH group. In silico analyses then revealed that 19 out of 31 sequences identified were homologous to known genes and 6 of these aligned to a CGI(s) located in the 5′ flanking region of a known gene (5′-CGI). These 6 genes therefore were chosen as putative candidates for further investigation. By comparing the degree of methylation of their 5′CGI in UCWBC DNA samples and levels of gene expression in FPT RNA samples we identified ACSL3 to have the highest inverse concordance in vivo. We then employed a lung cancer cell line (H1299) to demonstrate that the demethylation of ACSL3 5′-CGI by 5-aza-dC treatment induced enhancement of gene expression in H1299. Conversely, the treatment of H1299 with low doses of BaP, a PAH, was associated with dose-dependent hypermethylaiton of ACSL3 5-CGI and gene silencing. Collectively, these data strongly support methylation of the 5′-CGI of ACSL3 in gene regulation. They also provide evidence that PAH could directly induce ACSL3 promoter methylation. This well though out, step-wise approach allowed us to identify a candidate to be tested in the 56-sample study to determine whether methylation of the ACSL3 5′CGI could be a stand alone biomarker for PAH exposure and/or PAH-associated childhood asthma. Measuring human exposure to chemicals such as PAHs and determining their relationship to disease outcomes is a challenge for environmental health, especially when children are the study subjects. Although some studies have found a positive correlation between PAH-induced DNA adducts and mutagenesis or cancer development [29] others have failed to establish clear cause-effect relations between PAH adducts and the induction of these or other disease outcomes [30], suggesting that other mechanisms may be involved. Moreover, some of the methods for measuring genotoxic mechanisms such as adducts are complex and low-throughput. Therefore, it is of significance that, in this investigative study, we have developed a relatively simple, high throughput assay based on methylation of a sequence in the promoter of the ACSL3 gene that appears to distinguish children born to mothers with high airborne PAH exposure from those who were not (OR = 13.8; p<0.001) with high sensitivity (75%) and specificity (85%). The Area Under ROC curve (AUC) value for this assay was 0.82 suggesting excellent separability of the subjects with the methylated or unmethylated ACSL3sequence. This optimized MSPCR protocol allows for a rapid determination of ACSL3 5′-CGI methylation status in large sample sets, which is a normal requirement in population studies. It also has the added advantage to be developed into a minimally invasive test since only a small amount of DNA from UCWBC is required for the assay. If validated, such an assay is expected to have a high utility in the assessment of PAH exposure in future population-based studies. Multiple epidemiological studies have suggested that asthma risk is determined by prenatal and/or early life exposure to pollutants and allergens that modify later life lung function and T helper cell allergic phenotype [11]. Epigenetic modifications of regulatory genes crucial to the development of asthma-related pathophysiology have been put forth as a possible mechanistic basis of this disease [11]. Thus, asthma may be caused by epigenetic changes such as DNA methylation, post-translational modifications of histones, dysregulation of non-coding RNAs, and chromatin alterations. At present, the best studied mechanism is DNA methylation-mediated disruption of gene regulation. In this regard, experimental data indicating that DNA methylation of genes critical to the differentiation of T helper cells could skew their response towards or away from an allergic phenotype lend support to this theory [31]–[34]. Additionally, we recently demonstrated that inhaled diesel exposure (a source of PAHs) and intranasal Aspergillus fumigatus induced specific DNA methylation changes in the promoters of interferon-γ and interleukin-4 in T helper cells, respectively, and altered circulating levels of IgE in mice [35]. Despite progress made in experimental studies, fundamental questions related to asthma risk among human populations remain; these can only be addressed by cohort studies using specimens linked to well-annotated clinical and environmental exposure data. Such cohort-driven epigenetic research has the potential to address key questions, such as those concerning the influence of early life factors, environmental exposure, other disease states, and lifestyle factors on susceptibility to asthma. In this proof-of-principle study, we developed an innovative approach to population-based studies of environmental epigenetics, which could easily be implemented in future large-scale investigations. A range of approaches is available to obtain quantitative and qualitative information on genomic DNA methylation changes [27]. We chose methylation sensitive restriction fingerprinting ( MSRF; [19], [20] ) as a tool for the discovery of PAH-reprogrammable genes in UCWBC due to its high sensitivity, requirement for very small amounts of starting materials (∼100 ng), and the ease in visual identification of differentially methylated sequences among a moderately large number of samples. Using only four arbitrary primers and six permutations of MSRF analyses on UCWBC samples from the high and low PAH exposure groups, we discovered 31 differentially methylated sequences. In future studies more arbitrary primers could be used to cover a larger portion of the genome in order to uncover more candidates [27]. In this study we had overcome another technical hurdle related to the quantification of gene expression in UCWBC. This task is challenging because the amount of cellular components in umbilical cord blood is usually very limited and prohibitive for high quality RNA isolation. To circumvent this problem, in a subset of samples, we assessed the concordance between the extents of methylation in the promoter-CGI(s) of each gene (using UCWBC DNA samples) with its respective transcript expression levels in RNA samples isolated from matched FPT samples. This choice was based on the logic that both UCWBC and FPT are fetal tissues are subjected to similar environmental exposure through the mother. Our results demonstrated good concordance for at least the ACSL3 gene. In future design of such an epigenetic epidemiology experiment, preference should be given to improved techniques for the isolation of RNA and DNA from the UCWBC. ACSL3 belongs to the acyl-CoA synthetase long chain (ACSL) family of genes which encodes key enzymes in fatty acid metabolism [36]. ACSL3 is expressed in lung and thymic tissue [37], [38]. Intracellular conversion of long chain fatty acids to acyl-CoA is required for energy production. ACSL catalyzes the initial step in this conversion yielding acyl-CoAs, which are used both in the synthesis of cellular lipids and in degradation via beta-oxidation for energy production [39], [40]. Moreover, acyl-CoA synthetase can catalyze the ATP-dependent production of arachidonoyl-CoA that is a substrate for lysophosphatidyl acyltransferase involved in arachidonic acid-containing phospholipid remodeling in proliferating T cells [41]. Lipid metabolism influences membrane proteins, including ion channels. In the lung, ACSL3 is found most abundantly in microsomal and cell membrane fractions, with mitochondria as the next richest source [42]. Inhibition of ACS enzyme activity has been shown to cause cell death in p53-defective lung cancer cells [43]. Thus hypermethylation of this gene in T helper cells or lung tissues is expected to diminish fatty acid utilization and beta-oxidation-energy production, and possibly influence membrane phospholipid composition. Whether these functional changes directly affect asthma is unknown. However, several epidemiological studies show that fatty acid composition in milk [44], [45], diet [46], [47], and umbilical cord blood [48] affects the development of allergy and other inflammatory diseases including asthma. For example, dietary omega-3 (n-3) fatty acids having a variety of anti-inflammatory and immune-modulating effects may affect allergy and asthma. Further mechanistic studies in in vitro and in vivo experimental models are needed to decipher the role of ACSL3 in childhood asthma. Interestingly, ACSL3 is located in 2q36.1 which has recently been shown to be associated with regions of the asthma susceptibility loci, in specific populations [49]–[50] Finally, the current finding of a putative epigenetic marker that is associated with PAH exposure and asthma adds to other evidence from the CCCEH cohort that PAHs increase risk of respiratory symptoms and probable asthma. At age 2 years, significantly more difficulty breathing and more probable asthma were reported among children jointly exposed prenatally to PAHs and postnatally to environmental tobacco smoke (ETS) (OR for probable asthma = 7.52, 95% CI 1.71–33.11, p<0.01) [3]. These relationships were reexamined through age 5 years and similar trends were detected, with an observed interaction between high prenatal PAH exposure and postnatal ETS on wheeze and probable asthma at age 5 (OR = 5.48, 95% CI 1.17–25.58, p<0.01) (unpublished data). A parallel cohort study in Krakow, Poland has found a significant relationship between prenatal PAH exposure and respiratory symptoms [51]. In a subset of 333 subjects, PAH exposure measured during pregnancy by personal air monitors was associated with an increased risk for wheezing without cold (RR 3.8; 95% CI: 1.2–12.4), during the course of the infant's first year of life [51]. In conclusion, no previous studies have examined the effects of prenatal exposure to ambient air pollutants on DNA methylation patterns in genes potentially associated with the asthma phenotype of the offspring. This is an important gap in our understanding of asthma pathogenesis. Given the potential importance of epigenetic mechanisms in the etiology of childhood asthma, research is needed to identify an epigenetic profile related to PAH-associated childhood asthma and determine whether reprogramming events associated with transplacental exposure to PAHs increase risk of childhood asthma. The current report of ACSL3 as a candidate biomarker of PAH exposure and a putative predictor of PAH-associated childhood asthma represents an important first step in this area of research. Finally, the novel design of this study could serve as a prototype approach for future discoveries of additional exposure biomarkers or surrogate disease endpoints in other birth cohort studies. Materials and Methods Study Population Study subjects were nonsmoking Dominican and African American women and their children residing in Washington Heights, Central Harlem and the South Bronx participating in the CCCEH cohort study previously described [4]–[6]. Written informed consent was obtained from all subjects following procedures approved by the Institutional Review Board of the New-York Presbyterian Medical Center. Full enrollment into the study required completion of prenatal air monitoring and collection of a maternal and/or umbilical cord blood sample at delivery. As of November 1, 2007, 74% of the more than 600 fully enrolled subjects had been retained in the cohort through at least five years. During pregnancy and following delivery, a trained bilingual research team administered repeat questionnaires eliciting environmental and respiratory health histories [4]. There were no differences in demographics of subjects fully enrolled and those lost to follow-up [4]–[6]. Based on parental report of a doctor's diagnosis of asthma or probable asthma before the age of five, children were classified as “asthmatic” or “nonasthmatic.” (“with or without a parental report of asthma”). Study Sample Selection All subjects with stored UCWBC and paired FPT were eligible for inclusion in this proof-of-principle study. The population was dichotomized on the median PAH value of the entire cohort (2.3 ng/m3). Half of the 56 subjects in the present study were selected from among the ones above this median (the high PAH exposure group) and half from among those below the cohort median (the lower PAH exposure group). Twenty subjects (10 high and 10 low exposure) were used to identify UCWBC DNA sequences whose methylation status was dependent on maternal PAH exposure (high versus low) and to validate concordant transcript changes in matched FPT samples. All 56 samples were then used to validate the association between PAH exposure and ACSL3 5′CGI methylation and to explore the association between ACSL3 5′CGI methylation and childhood asthma status. Table 6 shows the characteristics of the cohort population and study sample, respectively. The sample was representative of the cohort population in terms of maternal age, child's sex, median PAH exposure, and percentage of children with probable asthma; however, the sample differed with respect to ethnicity. Table 7 showed the PAH distribution and variation in PAH levels in selected and unselected cohorts. Monitoring and Sample Collection Personal prenatal air monitoring was conducted for two consecutive days on all participants during the 3rd trimester of pregnancy as previously described [4]–[6]. Levels of pyrene and eight carcinogenic PAHs were analyzed (4). Total PAH levels for each participating mother were computed as the sum of the eight carcinogenic PAHs, where the values below the limit of detection were imputed as 0.125 ng/m3 (the median value between 0 and the limit of detection). Umbilical cord blood (30–60 mL) was collected at delivery. The buffy coat, packed red blood cells, and plasma samples were separated and stored at −80°C. DNA (100 ng–500 ng) was extracted from UCWBCs. For some UCWBC samples, matched FPTs were also available and total RNA was extracted using a TRIZOL® (Invitrogen, CA) according to manufacturer's protocol. All samples were coded. Methylation Sensitive Restriction Fingerprinting (MSRF) MSRF was performed in a single-blinded manner on asthma classification, as previously described [19], [20]. Five hundred ng of UCWBC DNA was restriction-digested using MseI [New England Biolabs, MA] alone or in combination with BstUI [New England Biolabs, MA] and amplified by PCR with various combinations of paired arbitrary primers (Table 8). Following electrophoresis, candidate sequences displaying differential methylation status between the “high PAH group” and “low PAH group” were isolated, extracted from the gel, cloned, identified and aligned with various databases. Sequences matched to known genes and with 5′-CGIs were selected for bisulfite genomic sequencing and confirmation studies of their regulatory function in gene expression. Six candidates [ACSL3, RAD21, DUSP22, SFMBT2, SCD5 and WWOX] were selected. Treatment of H1299 with 5-aza-dC and BaP H1299 cell line is a gift from Dr. Carolyn M. Klinge (University of Louisville) and were maintained in RPMI-1640 medium (Invitrogen, CA) supplemented with 10% fetal bovine serum (Hyclone, UT), 10 mM HEPES (Invitrogen, CA), 1 mM sodium pyruvate (Invitrogen, CA) and 4500 mg/L glucose (Invitrogen, CA). For demethylation assays, cells were treated with 0.5 and 1.0 µM 5-aza-dC (Tocris, MO) with DMSO (Sigma, MO) as control every 2 days for a total of 8 days. For BaP treatment, cells were exposed to 0.01, 0.1 and 1.0 nM BaP (Sigma, MO) with DMSO as control every 2 days for a total of 4 days. Medium was replenished with new drug of 5-AZA-dC or BaP every 48 hr. DMSO was added in the control samples. RNA was isolated, reverse transcribed and undergone real-time PCR. DNA was isolated, bisulfite-modified and undergone bisulfite genomic sequencing. Bisulfite genomic sequencing Genomic DNA (100 ng) from UCWBC samples or H1299 cells was modified with sodium bisulfite by using the EZ Methylation Modification Kit (Zymo Research, CA) before conducting PCRs. In silico analyses and detailed database searches were used to predict the 5′-CGI(s) in each gene. Primers were designed to amplify ∼0.9 to 1.4 kb fragments encompassing the 5′-CGI(s) of a candidate gene from bisulfite-modified DNA (Table 8). Amplicons were generated from individual UCWBC sample and subcloned into the pCR2.1 vector (Invitrogen, CA); eight or more clones were picked and sequenced (Macrogen, Korea). MSPCR analyses Bisulfite-modified genomic DNA was subjected to MSPCR analyses [27], [28]. Three sets of primers were designed to amplify regions (Figure 3A; R1, R2, and R3) within the 5′-CGI that exhibited the highest degree of differential methylation between the high and low PAH group. For each region, the M primer set amplifies the target sequence when it is methylated; the U primer set only amplifies the unmethylated allele (Table 8). Thirty-five-cycle PCRs were performed with 1 unit Platinum Taq DNA polymerase (Invitrogen, CA) using the following conditions: denature at 94°C for 30 s, anneal at 58°C for 1-min, and extend at 72°C for 1-min, followed by 12-min final extension. PCR products were separated on 2% agarose gel and visualized with ethidium bromide. Real-time reverse-transcriptase-PCR (real time RT-PCR) Total RNA was isolated from FPT samples matched to UCWBC samples or from H1299 cells as previously reported [14], [16]. Steady state mRNA levels of the genes under investigation were quantified by SYBR Green-based real time RT-PCR with normalization to β-actin as previously described [14], [16]. Primers specific for quantification of transcripts of the selected genes are listed in Table 8. Three separate real time RT-PCRs were performed on each FPT sample to obtain a mean value. The 2-ΔΔCt method was used to calculate the relative expression level of transcripts normalized to β-actin. The mean value from a universal reference RNA (Clontech, CA) was arbitrarily assigned an abundance value of 1.00 for each gene. Mean values from all other samples were normalized against this sample. Statistical methods The Kendall coefficient of concordance (tau) was calculated to measure the strength of the relationship between the percent of methylation of a gene's promoter CGI in UCWBC DNA samples and its transcript expression level in matched FPT RNA samples. Ninety-five percent confidence intervals and 2-tailed p-values were obtained to determine the expected range and significance of observed tau values. Chi-square tests were performed to investigate possible differences in the percents of African Americans, males, and methylated subjects between categories of PAH exposure, (<2.41, ≥2.41). Odds ratios and 95% confidence intervals of high PAH exposure for each of the three characteristics were calculated and tested for statistical significance. The cutpoint of 2.41 was determined from an ROC curve analysis following logistic regression of methylation status on continuously measured PAH exposure. This value separated methylated and unmethylated subjects according to ‘high/low’ PAH exposure. We considered MSPCR to be methylated above 2.41 and unmethylated below 2.41. Logistic regression was performed to evaluate the association between parental report of asthma (dependent variable) and methylation status (independent variable). First, methylation status was modeled alone; then gender and ethnicity were added to the model. The parameter estimate and standard error of methylation status changed less then 15% when adjusted for gender and ethnicity, therefore the unadjusted odds ratio was presented. The equality of the median PAH exposure levels between methylated and unmethylated subjects was tested by the non-parametric Kruskal-Wallis test. For all analyses a 5% alpha level indicated significance unless stated otherwise. Analyses were performed using SAS, Version 9.1 (SAS Institute, Cary, NC).
This invention relates to methods of and apparatus for overcladding a glass rod. More particularly, this invention relates to methods and apparatus for causing a glass tube to be collapsed onto a glass rod to provide an optical fiber preform. Optical fiber of the type used to carry optical signals is fabricated typically by heating and drawing a portion of an optical preform comprising a refractive core surrounded by a protective glass cladding. Presently, there are several known processes for fabricating preforms. The modified chemical vapor deposition (MCVD) process, which is described in U.S. Pat. No. 4,217,027 issued in the names of J. B. MacChesney et al. on Aug. 12, 1980 and assigned to Bell Laboratories, Inc. has been found to be one of the most useful because the process enables large scale production of preforms which yield very low loss optical fiber. During the fabrication of preforms by the MCVD process, reactant-containing gases, such as SiCl4 and GeCl4 are passed through a rotating substrate tube which is made of silica glass. A torch heats the tube from the outside as the precursor gases are passed therethrough, causing deposition of submicron-sized glass particles on the inside surface of the tube. The torch is moved along the longitudinal axis of the tube in a plurality of passes to build up layer upon layer of glass to provide a preform tube. Once a sufficient number of layers have been deposited, the preform tube is then heated to cause it to be collapsed to yield a preform or preform rod as it is often called. One way in which the productivity of the MCVD process can be increased is first to produce an undercladded preform, having a larger than desired core-to-cladding mass ratio. The preform is inserted into a glass tube which is referred to as an overcladding tube and which is then collapsed onto the preform. This process is referred to as the rod in tube technique, or RIT. At the present time, production methods of manufacturing overclad preforms are usually performed on a vertical lathe, with a vacuum arrangement attached to the lower headstock of the lathe. The lower headstock of the lathe has a chuck mounted thereon attached to a spindle which provides rotary motion. There is no relative motion between the chuck and the vacuum arrangement. A heating member, such as an oxyhydrogen torch, is made to travel along the length of the rod with the overcladding tube surrounding it to soften the tube and collapse it about the rod. The vacuum arrangement creates a low pressure or vacuum to provide a pressure bias to the tube to aid in its collapse, and, also, to remove possible contaminants that may have been interjected into the space between the rod and the tube prior to the collapse of the latter. Such a vacuum arrangement, including the apparatus for generating the vacuum, severely limits the length of the overclad preform product, thereby inhibiting the use of enhanced production techniques which require, for example, longer preforms. One widely used vacuum apparatus comprises a hollow circular cavity concentric with the spindle centerline of rotation, the bottom of the cavity being perpendicular to the centerline or axis of rotation. The top of the cavity is open to the atmosphere. The cavity diameter may be appropriately sized to allow for various tube diameters to be inserted. The closed end of the cavity has an axial bore therein to link to a rotary union member which is attached to the vacuum structure. As a consequence, a vacuum source may be supplied in the stationary reference frame of the lathe and linked to the cavity which rotates when the headstock or tailstock spindle is rotating. A cylindrical insert is placed inside of the cavity, having a diameter roughly equal to the cavity interior diameter. This insert has a lower surface parallel to the bottom of the cavity and rests on the bottom thereof. The upper surface is also parallel to the bottom of the cavity and has a washer of refractory material mounted thereon. Both the insert and the washer have a central or axial hole extending therethrough which allow routing of the vacuum source to the upper surface, while the lower surface of the insert forms a mechanical seal with the cavity. There may be some leakage in this sealing arrangement, however, it is generally insufficient to necessitate aborting the operation. The end of the overclad tube, which has been prepared, as by grinding, to be perpendicular to its cylindrical axis, rests on the refractory washer surface, forming a seal therewith, which may have some leakage. The washer thus functions as an axial position spacer and as a face seal between the overclad tube and the insert. The vacuum source, with this arrangement, is thus routed to the interior of the overclad tube. Once the tube has been positioned with its own weight exerting the sealing force on the refractory washer, the jaws of the lathe chuck are closed so that the tube is clamped rotationally and axially in position and the vacuum is transferred through the rotary union to the interior of the overclad tube. The tube cannot be moved axially for repositioning without breaking the seal. Thus, the span between the headstock and the tailstock of the lathe, at maximum separation, imposes a limit on the combined length of the rod to be inserted in the tube and the tube itself. This, in turn, limits the length of the preform product, thereby limiting the production process and preventing enhancement thereof or any increase in preform length. In addition, the heating element can only apply the desired heat to a limited length of rod-in-tube which represents a further limitation on the length of the finished preform. Any axial adjustments or relative movement of the rod and the tube are also prevented, or, at least, limited. It is desirable, therefore, that such limitation on the length of the preform be eliminated, or at least reduced so that, in accordance with enhanced production, longer preforms may be produced. The present invention is a sealing arrangement that, in effect, eliminates dependency upon the sealing interface between the heretofore used insert and the bottom of the cavity and the sealing interface between the end of the tube and the refractory washer by eliminating both the insert and the washer, and thereby making axial adjustment feasible. As a consequence, as will be seen more clearly hereinafter, the length of the tube within the rod portion can be measurably increased with the net result that longer preforms are created. In greater detail, the longitudinal stem of the rotary union, at its distal end, has a disposable seal mounting hub interface. A disposable resilient sealing member of suitable material, such as Teflon(copyright) or hard rubber, for example, is fastened to the distal end of the stem at the hub interface. The sealing member has an outside diameter that is a sealing fit within the internal diameter of the tube. By xe2x80x9csealing fitxe2x80x9d is meant a fit sufficiently tight to constitute a substantially hermetic seal but not so tight that the tube cannot be axially moved relative thereto. Some leakage at the seal may occur, but as the vacuum or pressure differential increases, so too does the sealing capability of the seal. As the overclad tube is lowered into the cavity, the seal system is engaged and vacuum application can start as soon as the engagement of the sealing member, with the ID (inner diameter) of the tube takes place. The tube can then be axially positioned as required without engagement for sealing purposes of the end thereof. If the tailstock (or headstock) of the lathe has a pass through bore, it can be appreciated that a tube of greater length than has heretofore been possible may be used, which may be moved axially to bring more tube length into the heating region without destroying the vacuum seal. The chuck of the lathe headstock or tailstock is used to clamp the tube in place, and may be loosened to allow moving of the tube axially and then reclamped. The rotary union, which has its rotating portion connected to the sealing member and its stationary portion connected to the vacuum apparatus, is dependent upon the friction between the sealing member and the tube for driving the rotating portion as the tube is rotated. With a tight seal, the rotation of the tube is transmitted to the rotary union substantially without slippage and the seal remains intact. Alternatively, the tightness of the seal can be such that the tube rotates with respect to the sealing member without compromising the seal. Adjustments can be made to select any combination between these two extremes, such as stationary (seal within the tube) wherein the rotary portion rotates, combination seal/rotary union rotation, or seal only rotation (relative to the tube). The amount of leakage and vacuum properties of the seal will necessarily vary depending upon which option is chosen, or which is caused by environmental or production line conditions, without destroying the integrity of the seal. With the structure of the invention as hereinbefore described, axial movements and adjustments between the rod and the seal can be made without destroying the vacuum seal, thereby making possible considerable production enhancement, such as much longer preforms, than heretofore achievable.