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effect of short-term castration and starvation upon hypothalamic content of luteinizing hormone-releasing hormone in adult male rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
52,
64
]
} | {
"id": "C0023610",
"name": "luteinizing hormone-releasing hormone",
"pos": [
76,
113
]
} |
within 7 days after castration there is a significant decline in hypothalamic content of lh-rh in adult male rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
65,
77
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
89,
94
]
} |
total starvation for 7 days does not affect hypothalamic content of lh-rh in either intact or castrated rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
44,
56
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
68,
73
]
} |
a slightly decreased fragility curve by 24 hr incubated red cells , the increase of autohemolysis and the appearance of heat labile hemoglobin were observed after exertion . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
56,
65
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
132,
142
]
} |
the erythrocyte and leukocyte counts were found to come back to normal soonest , while the weight gain , the amount of hemoglobin , the percentage of pseudoeosinophiles and the gamma-globulins were normalized less quickly , and the total protein and the percent of lymphocytes were not normalized at all . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
4,
15
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
119,
129
]
} |
it is supposed that two successive processes take place in thyroid gland : a synthesis of thyroglobulin subunits and an exchange of new synthesized subunits with presynthesized ones . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid gland",
"pos": [
59,
72
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
90,
103
]
} |
the effect of iodide administration on hog thyroid gland and the composition of thyroglobulin and 27-s iodoprotein . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid gland",
"pos": [
43,
56
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
80,
93
]
} |
the effect of excess iodide on hog thyroid gland has been examined with regard to the change in the chemical composition of thyroglobulin and in the accumulation of 27-s iodoprotein by the in vivo treatment of hogs with iodide for various lengths of time . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid gland",
"pos": [
35,
48
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
124,
137
]
} |
comparative evaluation of the tsh effect on the synthesis of different thyroidal proteins shows that it has a much more specific and significant action on thyroglobulin than on other proteins . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroidal",
"pos": [
71,
80
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
155,
168
]
} |
to evaluate the red blood cell trauma caused by the hemodialyser , free hemoglobin was determined in the plasma before and after various types of hemodialysis . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red blood cell",
"pos": [
16,
30
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
72,
82
]
} |
the blastogenic responses of lymphocytes to pha-stimulation and lymphocyte lymphokine production have been studied in 27 patients undergoing total hip replacement , operated under either general anaesthesia or epidural anaesthesia . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
29,
40
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
75,
85
]
} |
control lymphocytes incubated in sera from general anaesthetized patients resulted in significantly lower lymphokine activity ( p less than 0.05 ) in comparison with cultures with sera from patients in the epidural group . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
8,
19
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
106,
116
]
} |
whether this tumor polypeptide is identical to native hypothalamic gh-releasing hormone remains to be proved . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
54,
66
]
} | {
"id": "C0037668",
"name": "gh-releasing hormone",
"pos": [
67,
87
]
} |
red cell haemoglobin ( hb ) , haematocrit ( ht ) , 2,3-diphosphoglycerate ( dpg ) , and adenosine triphosphate ( atp ) levels were measured in 876 individuals from six villages at two altitude levels ( altiplano and coast ) of the departmento de arica of northern chile . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
0,
8
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
9,
20
]
} |
the effect of 3'-mdab on liver specific gene expression was also studied with albumin and alpha-fetoprotein ( afp ) genes as models . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
25,
30
]
} | {
"id": "C0002210",
"name": "alpha-fetoprotein",
"pos": [
90,
107
]
} |
significant ( p less than 0.05 ) between-stage differences were detected in thalamic bombesin , thalamic and hypothalamic neurotensin , and cerebellum somatostatin concentrations . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
109,
121
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
151,
163
]
} |
significant ( p less than 0.05 ) peptide concentration versus physiological stage correlations were found in cerebral cortex and hypothalamic cholecystokinin and hypothalamic somatostatin concentrations . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
129,
141
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
175,
187
]
} |
the amount of fp required for lysis is less than 0.1 % of the haem in erythrocytic haemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocytic",
"pos": [
70,
82
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
83,
94
]
} |
these findings in the hypothalamus are significant and may represent the electrophysiologic correlates of changes in corticotrophin releasing factor in this region . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
22,
34
]
} | {
"id": "C0010132",
"name": "corticotrophin",
"pos": [
117,
131
]
} |
in order to evaluate the possible underlying factors for the increase in red cell 2,3-diphosphoglycerate content observed in late diabetic pregnancy , its relationship with serum unconjugated oestriol , human placental lactogen , haemoglobin and hydrogen ion concentrations was investigated in 42 pregnant diabetic women . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red",
"pos": [
73,
76
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
230,
241
]
} |
the basement membrane zone ( bmz ) of human skin is a complex structure which contains several well-defined components including bullous pemphigoid antigen , laminin , type iv collagen , and proteoglycan . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
4,
21
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
168,
184
]
} |
these findings confirm the existence of regional variation in bm composition , and demonstrate for the first time that the lamina densa of stratified squamous epithelial bms contains a constituent other than type iv collagen . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "bm",
"pos": [
62,
64
]
} | {
"id": "C0009333",
"name": "type iv",
"pos": [
208,
215
]
} |
lm , a noncollagenous basement membrane protein , plays a role in epithelial adhesion to type iv collagen , and is normally present in the dej , but absent in the epidermis . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
22,
39
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
89,
105
]
} |
the release of hydroxyproline-containing fragments from the basement membrane indicated that degradation of the type iv collagen component of the basement membrane was occurring . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
60,
77
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
112,
128
]
} |
type iv collagen is one of the main constituents of basement membranes , yet it is unknown whether the structural framework at different sites is assembled from one unique type of molecule or whether different type iv collagen molecules exist . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membranes",
"pos": [
52,
70
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
210,
226
]
} |
in immunofluorescence experiments the monoclonal antibodies stained all basement membranes in kidney , lung , placenta , or skin , suggesting that at least the type iv collagen molecule recognized by these monoclonal antibodies is shared by a variety of vascular and epithelial basement membranes . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membranes",
"pos": [
72,
90
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
160,
176
]
} |
the immunologically isolated [ 3h ] thrombospondin migrated in nadodso4/polyacrylamide gels with purified marker platelet thrombospondin both with and without reduction . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
113,
121
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
122,
136
]
} |
mitogens that are not angiogenic , such as insulin , epidermal and fibroblast growth factors , and endothelial cell growth supplement , had no effect on bce cell pa and collagenase activities . | tissue_is_expression_site_of_gene_product | {
"id": "C0225336",
"name": "endothelial cell",
"pos": [
99,
115
]
} | {
"id": "C0032144",
"name": "pa",
"pos": [
162,
164
]
} |
ir-rscp was present in neuronal cell bodies , processes , and axon terminals in the hypothalamic tuberoinfundibular system as well as in diverse regions of the central nervous system in an identical distribution to immunoreactive somatostatin . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
84,
96
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
230,
242
]
} |
in 74 patients without residual thyroid tissue and a negative whole body thallium and/or iodine scan , the tg concentration in plasma was undetectable . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
32,
39
]
} | {
"id": "C0040123",
"name": "tg",
"pos": [
107,
109
]
} |
b-cell function and islet cell and other organ-specific autoantibodies in relatives to insulin-dependent diabetic patients . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet cell",
"pos": [
20,
30
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
87,
94
]
} |
we have developed a new short term in vitro system to examine hypothalamic somatostatin ( srif ) release . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
62,
74
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
90,
94
]
} |
hypothalamic cells were obtained from normal rats after trypsin or collagenase aided dispersion and released immuno-reactive ( ir ) srif which eluted in 3 molecular weight ( mw ) forms on gel chromatography . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
0,
12
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
132,
136
]
} |
these observations that islet cells contain specific receptors for estrogen when combined with the clinical observations , suggest that estrogens have a direct effect on the islet cells that may modulate the release of insulin . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet",
"pos": [
24,
29
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
219,
226
]
} |
in adult rhesus monkeys bearing hypothalamic lesions that abolished secretions of lh and fsh , normal circulating levels of these hormones and consequent follicular development culminating in ovulation were reestablished by the administration of a gnrh pulse once every hour ( control frequency ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
32,
44
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
248,
252
]
} |
in rat pancreatic islets , the effect of old age ( 24-month-old ) on [ 125i ] insulin binding , glucose-induced insulin release and inhibition of insulin secretion by exogenous insulin were studied . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
7,
24
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
177,
184
]
} |
the data indicate that the reported inhibition of glutamine degradation in the perfused liver at low ph [ e.g . haussinger et al . ( 1980 ) hoppe-seyler 's z. physiol . chem . 361 , 995-1001 ] is due to a decreased affinity of glutaminase for ammonia . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
88,
93
]
} | {
"id": "C0017796",
"name": "glutaminase",
"pos": [
227,
238
]
} |
plasma lh levels were depressed by hyperprolactinemia although the content of hypothalamic luteinizing hormone-releasing hormone ( lhrh ) was not changed . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
78,
90
]
} | {
"id": "C0023610",
"name": "luteinizing",
"pos": [
91,
102
]
} |
the significance of the sodium and potassium content of muscle tissue and the relation of the amount of edema fluid in muscle to the level of serum protein in experimental nutritional edema . | tissue_is_expression_site_of_gene_product | {
"id": "C0026845",
"name": "muscle tissue",
"pos": [
56,
69
]
} | {
"id": "C0026832",
"name": "muscle",
"pos": [
119,
125
]
} |
these experiments do not support the premise that either growth hormone and ( or ) testosterone are the blood-borne agents that interact directly with muscle to stimulate protein accretion , because neither growth hormone nor testosterone acted directly on muscle cells in vitro to stimulate muscle protein accumulation . | tissue_is_expression_site_of_gene_product | {
"id": "C0026845",
"name": "muscle",
"pos": [
151,
157
]
} | {
"id": "C0026832",
"name": "muscle protein",
"pos": [
292,
306
]
} |
during this process , urothelial cells express prostatic histochemical markers ( alkaline phosphatase , nonspecific esterase , glycosaminoglycans ) and prostate-specific antigens . | tissue_is_expression_site_of_gene_product | {
"id": "C0033572",
"name": "prostatic",
"pos": [
47,
56
]
} | {
"id": "C0138741",
"name": "prostate-specific antigens",
"pos": [
152,
178
]
} |
various determinations including erythrocyte 2,3-diphosphoglycerate ( 2,3-dpg ) , oxyhemoglobin dissociation ( p50 ) , serum phosphate , calcium , lactate , pyruvate , electrolytes , and response time to reach predetermined values for glucose , bicarbonate , and ph were measured at frequent intervals during the first 24 h of therapy and daily for 5 days after metabolic control . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
33,
44
]
} | {
"id": "C0030069",
"name": "oxyhemoglobin",
"pos": [
82,
95
]
} |
immunocytochemical stains for three epithelial cell markers -- keratin , epithelial membrane antigen ( ema ) and carcinoembryonic antigen ( cea ) -- have been examined on paraffin-embedded material from 14 patients with nasopharyngeal carcinoma ( npc ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0014597",
"name": "epithelial cell",
"pos": [
36,
51
]
} | {
"id": "C0007082",
"name": "carcinoembryonic antigen",
"pos": [
113,
137
]
} |
suppressor cell induction factor : a new mediator released by stimulated human lymphocytes and distinct from previously described lymphokines . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
79,
90
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
130,
141
]
} |
the relationship between the testes and the adenohypophysis in rats exposed to heat was assessed by ( 1 ) the determination of adenohypophysial concentrations of fsh , lh and prolactin as well as serum levels of prolactin and testosterone in rats maintained at 35 degrees c for various periods of time and ( 2 ) the elucidation of the responsiveness to stimulation with gonadotrophin releasing hormone ( gnrh ) or human chorionic gonadotrophin ( hcg ) of the rat acclimatized for 40 days to a temperature of 35 degrees c . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "adenohypophysial",
"pos": [
127,
143
]
} | {
"id": "C0033371",
"name": "prolactin",
"pos": [
212,
221
]
} |
the oxygenation-linked , allosteric interactions of erythrocytic organic phosphates and urea with the haemoglobin ( hb ) , and the functional significance of the hb multiplicity , were studies in an elasmobranch , squalus acanthias . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocytic",
"pos": [
52,
64
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
162,
164
]
} |
the autochthonous red cell nucleoside triphosphates ( ntp ) atp and gtp ( guanosine triphosphate ) strongly depress o2 affinity of the stripped ( cofactor-free ) hb and increase cooperativity in o2 binding . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
18,
26
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
162,
164
]
} |
this data suggests that blockade of different subgroups of dopamine receptors in the anterior pituitary gland labeled by 3h-spiperone may be responsible for the in vivo stimulation of prl secretion by the benzamide and non-benzamide neuroleptic drugs . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "anterior pituitary gland",
"pos": [
85,
109
]
} | {
"id": "C0033371",
"name": "prl",
"pos": [
184,
187
]
} |
it has been observed that gh secretion is in part controlled by hypothalamic gh release-inhibiting factors , two forms of which , somatostatin-14 ( ref . 5 ) and somatostatin-28 ( refs 6-9 ) , have been characterized . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
64,
76
]
} | {
"id": "C0037659",
"name": "somatostatin-14",
"pos": [
130,
145
]
} |
synthetic versions of these human pancreatic tumour gh-releasing factors ( hpgrfs ) were found to be potent gh secretagogues in vitro and in vivo and to exhibit actions and interactions similar to those observed with partially purified hypothalamic grf . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
236,
248
]
} | {
"id": "C0023610",
"name": "grf",
"pos": [
249,
252
]
} |
gh-releasing peptides have been purified from hypothalami of various species but the structure of natural hypothalamic grf has not yet been reported . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "structure",
"pos": [
85,
94
]
} | {
"id": "C0023610",
"name": "grf",
"pos": [
119,
122
]
} |
we propose that this polypeptide , which shows 67 % homology with the corresponding n-terminal 43 residues in hpgrf-44 , is the long-sought rat hypothalamic grf ( rhgrf ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
144,
156
]
} | {
"id": "C0023610",
"name": "grf",
"pos": [
165,
168
]
} |
the production of stable t-cell clones is essential for the study of t-cell-derived , specific immunoregulatory products and of specific t-cell receptors . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t-cell",
"pos": [
25,
31
]
} | {
"id": "C0034790",
"name": "t-cell",
"pos": [
137,
143
]
} |
responsiveness of adenohypophysial corticotrophs to hypothalamic ( sme ) extract remains unchanged in rats with hypothalamic lesions inhibiting crf release . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
52,
64
]
} | {
"id": "C0010132",
"name": "crf",
"pos": [
144,
147
]
} |
radioisotope cisternography was performed and the erythrocyte and hemoglobin contents of the cerebrospinal fluid ( csf ) were determined within the first 4 days after subarachnoid hemorrhage in 42 patients . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
50,
61
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
66,
76
]
} |
this high specific activity reagent was then used in an attempt to identify proteases in rat islets of langerhans involved in the conversion of proinsulin to insulin . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islets of langerhans",
"pos": [
93,
113
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
158,
165
]
} |
slight , but statistically significant , decreases in rbc ( 13 % below control ) and hgb , accompanied by an increase in mch ( 11 % above control ) were observed in the 77 ppm-exposed females after 6 weeks . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
54,
57
]
} | {
"id": "C0019046",
"name": "hgb",
"pos": [
85,
88
]
} |
since the degradation of tg and its stimulation by me are known to depend on the mean iodine content of the molecule , it was concluded that : 1 ) the recently iodinated tg population contains both poorly and fully iodinated molecules , the degradations of which are faster or similar to that of 48 h-iodinated tg , respectively , 2 ) among thyroid phagolysosomes , only those which exhibit a ph-dependent proteolytic activity contain poorly iodinated molecules while others , which are functional at either ph , contain solely fully iodinated molecules ( 1 and 48 h labelled ) , 3 ) reduction of the disulphide bridges of fully iodinated tg , mediated by me and probably a lysosomal transhydrogenase , is a prerequisite for its optimal degradation by lysosomal proteinases , 4 ) in addition , tsh , which preferentially stimulates the degradation of fully iodinated tg , was concluded to interfere directly upon the intralysosomal hydrolytic process , independently of its effect upon tg endocytosis . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
341,
348
]
} | {
"id": "C0040123",
"name": "tg",
"pos": [
986,
988
]
} |
the increased da turnover in the hypothalamus suggested as inhibitory on gnrh neurons could account for this effect . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
33,
45
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
73,
77
]
} |
the study indicates that ethanol does not have a direct gonadotoxic effect on the ovary but indicates that ethanol has an effect on the hypothalamus and/or the pituitary , thereby disrupting the synthesis and/or release of luteinizing hormone releasing hormone ( lhrh ) or luteinizing hormone ( lh ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
136,
148
]
} | {
"id": "C0023610",
"name": "luteinizing",
"pos": [
273,
284
]
} |
various putative neurotransmitters affect growth hormone ( gh ) release in rats with anterolateral hypothalamic deafferentation of the medial basal hypothalamus : evidence for mediation by a gh-releasing factor . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
148,
160
]
} | {
"id": "C0037668",
"name": "gh-releasing factor",
"pos": [
191,
210
]
} |
we have measured gnrh-r in pituitaries of hypogonadotrophic hypogonadal ( hpg ) mice , in whom hypothalamic gnrh is deficient or absent . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
95,
107
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
108,
112
]
} |
it was also determined by competitive blocking experiments that nkp-15 recognizes a new nk cell surface antigen not delineated by the nk-specific monoclonal antibody , leu-7 , and that the epitope for nkp-15 appears to be associated with the fc-receptor of nk cells and granulocytes . | tissue_is_expression_site_of_gene_product | {
"id": "C0022688",
"name": "nk",
"pos": [
64,
66
]
} | {
"id": "C0382839",
"name": "receptor",
"pos": [
245,
253
]
} |
antigens of the basement membrane ( type-iv collagen and laminin ) and the connective tissue ( type-iii collagen and fibronectin ) were studied by immunofluorescence in 16 lymph nodes draining colorectal carcinomas and 6 lymph nodes draining breast carcinomas . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
16,
33
]
} | {
"id": "C0009333",
"name": "type-iv collagen",
"pos": [
36,
52
]
} |
the amounts of the radioactive gbps synthesized in human fibroblasts are proportional to the amounts of the purified beta-interferon used for the inductions . | tissue_is_expression_site_of_gene_product | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
57,
68
]
} | {
"id": "C0015980",
"name": "beta-interferon",
"pos": [
117,
132
]
} |
furthermore , the conversion of the mr = 15,000 somatostatin species by hypothalamic enzyme activities led to the formation of both somatostatin-14 and -28 which were identified by high pressure liquid chromatography . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
72,
84
]
} | {
"id": "C0037659",
"name": "somatostatin-14",
"pos": [
132,
147
]
} |
acetylcholinesterase ( the a12 form ) binds best to the basement membrane heparan sulfate proteoglycan and type v collagen , to a lesser extent to laminin , fibronectin , and type i collagen , but not to type iv collagen . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
56,
73
]
} | {
"id": "C0009333",
"name": "type",
"pos": [
204,
208
]
} |
thyroid uptake correlated directly with serum t3 , the t3 to t4 ratio , and serum tg . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
0,
7
]
} | {
"id": "C0040123",
"name": "tg",
"pos": [
82,
84
]
} |
in addition , it was found that lymphocytes cultured without stimulating cells for 5 days in medium supplemented with supernatants from secondary mlc that are known to contain high levels of lymphokines , mediated high levels of cytotoxicity on all the transformed cells tested , but lacked detectable cytotoxic activity for syngeneic or allogeneic con a blasts . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
32,
43
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
191,
202
]
} |
the present study was concerned with the effects of bff on the hypothalamic release of lh releasing hormone ( lh-rh ) into hypophysial stalk blood and on the metabolic clearance rates of gonadotrophins . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
63,
75
]
} | {
"id": "C0023610",
"name": "lh releasing hormone",
"pos": [
87,
107
]
} |
the increase after hpgrf-40 in serum gh levels in this patient and the similar or greater responses in 3 of 7 patients suggest that at least some of these patients may have hypothalamic gh-releasing-hormone deficiency . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
173,
185
]
} | {
"id": "C0037668",
"name": "gh-releasing-hormone",
"pos": [
186,
206
]
} |
thus , the ap-implanted rat is not only a valid model of excess and abnormal prl secretion , but it may also be useful for distinguishing between stimuli requiring an intact hypothalamic-pituitary unit and agents which act directly on the pituitary gland . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "ap",
"pos": [
11,
13
]
} | {
"id": "C0033371",
"name": "prl",
"pos": [
77,
80
]
} |
we also examined their myogenic ( myo ) phenotype by determining their ability to develop into mature myotubes , to express elevated levels of muscle creatine kinase , and to synthesize muscle-characteristic proteins as detected by two-dimensional polyacrylamide gel electrophoresis . | tissue_is_expression_site_of_gene_product | {
"id": "C0026845",
"name": "muscle",
"pos": [
143,
149
]
} | {
"id": "C0026832",
"name": "muscle",
"pos": [
186,
192
]
} |
insulin-dependent diabetes mellitus ( iddm ) usually begins in childhood or early adulthood , and its aetiology is thought to involve autoimmune damage to the islet cells that secrete insulin . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet cells",
"pos": [
159,
170
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
184,
191
]
} |
a trial course of orally administered iron is suggested for children who are found to have an elevated ep value , with an increase in hemoglobin or hematocrit value serving , retrospectively , as confirmation of prior iron deficiency . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "ep",
"pos": [
103,
105
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
134,
144
]
} |
this model system should provide an approach to study , in more depth , the mechanism by which cyclic nucleotides or their inducers can modulate the latter stages of the lymphocyte proliferative response , which is mediated by the lymphokine , il-2 . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocyte",
"pos": [
170,
180
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
231,
241
]
} |
three human gingival fibroblast cell lines were used to determine whether they could be induced by a synthetic rna and superinduced by metabolic inhibitors to produce interferon ( ifn-beta ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
21,
31
]
} | {
"id": "C0015980",
"name": "ifn-beta",
"pos": [
180,
188
]
} |
when established procedures were followed for human fetal or newborn skin fibroblast cell lines , the adult gingival fibroblasts produced comparable amounts of ifn-beta . | tissue_is_expression_site_of_gene_product | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
117,
128
]
} | {
"id": "C0015980",
"name": "ifn-beta",
"pos": [
160,
168
]
} |
in pool i of the normal thyroid gland , the respective values were 62.8 micrograms tg/mg equivalent tissue , 21.3 +/mole 127i/mole tg , and 15.4 mole sialic acid/mole tg . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid gland",
"pos": [
24,
37
]
} | {
"id": "C0040123",
"name": "tg",
"pos": [
167,
169
]
} |
we conclude that the hypothalamus ( rather than the pituitary ) is a principal site for the negative feedback of androgen in rams and that an increased frequency of lhrh discharge into the hypothalamo-hypophysial portal system contributes significantly to the post-castration rise in serum lh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
21,
33
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
165,
169
]
} |
the aii receptors in the anterior pituitary gland are located in lactotrophs and corticotrophs and mediate the stimulatory actions of aii upon prolactin and acth secretion , acting in conjunction with other hypothalamic regulators . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "anterior pituitary gland",
"pos": [
25,
49
]
} | {
"id": "C0033371",
"name": "prolactin",
"pos": [
143,
152
]
} |
for this reason we measured hypothalamic and reproductive tissue levels of trh-ir , hypothalamic levels of somatostatin ( srif ) , and beta-endorphin ( ep ) , serum levels of prolactin ( prl ) , growth hormone ( gh ) , thyrotropin ( tsh ) , and thyroxine ( t4 ) in young , sexually mature and 24-28 month-old male long-evans and sprague-dawley rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
28,
40
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
122,
126
]
} |
aging did not change the ratio of trh to the major trh-like peptide in prostates , as determined by high pressure liquid chromatography ( hplc ) or the levels of hypothalamic srif and ep . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
162,
174
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
175,
179
]
} |
the data demonstrate a direct action of srif analogs on the hypothalamus to suppress srif-li release and are consistent with the possibility that an endogenous peptide participates in 'ultrashortloop ' negative feedback control of its own secretion in the intact animal . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
60,
72
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
85,
89
]
} |
release of prostaglandin e2 from the hypothalamus depends on extracellular ca2+ availability : relation to lhrh release . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
37,
49
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
107,
111
]
} |
the results clearly showed that in the terminal region of the hypothalamic lhrh system the release of this hormone and the action of pge2 were not altered by starvation . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
62,
74
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
75,
79
]
} |
inhibition of transglutaminase by hypoglycaemic sulphonylureas in pancreatic islets and its possible relevance to insulin release . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic",
"pos": [
66,
76
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
114,
121
]
} |
pancreatic islet homogenates display calcium-sensitive transglutaminase activity , but the role of this enzyme in the process of insulin release remains to be elucidated . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islet",
"pos": [
0,
16
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
129,
136
]
} |
hypothalamic regulation of luteinizing hormone ( lh ) secretion and ovarian function were investigated in beef heifers by infusing lh-releasing hormone ( lhrh ) in a pulsatile manner ( 1 microgram/ml ; 1 ml during 1 min every h ) into the external jugular vein of 10 hypophysial stalk-transected ( hst ) animals . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
0,
12
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
154,
158
]
} |
two generations of red cells ( embryonic and definitive ) , different types of haemoglobins , and special organic phosphates involved in the control of haemoglobin oxygenation ( 2:3-bisphosphoglycerate , bpg , and inositol-5-phosphate , ip5 ) , have been found progressively during development of the chick . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
19,
28
]
} | {
"id": "C0019046",
"name": "haemoglobins",
"pos": [
79,
91
]
} |
several constituents of basement membranes , including type iv collagen , laminin , heparan sulphate proteoglycan and nidogen , form a defined supramolecular complex that is an obligatory intermediate in the formation of this matrix . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membranes",
"pos": [
24,
42
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
55,
71
]
} |
major components of basement membranes , including collagen iv , laminin , heparan sulphate proteoglycan and nidogen , were isolated from the matrix of the ehs sarcoma . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membranes",
"pos": [
20,
38
]
} | {
"id": "C0009333",
"name": "collagen iv",
"pos": [
51,
62
]
} |
while the composition of basement membranes is still incompletely known , several components have been identified , including collagen types iv and v , laminin and heparan sulphate proteoglycan . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membranes",
"pos": [
25,
43
]
} | {
"id": "C0009333",
"name": "collagen types iv",
"pos": [
126,
143
]
} |
parietal endoderm cells are a rich source of mrnas for basement membrane components and have been used to prepare a cdna library in the expression vectors puc8 and puc9 from which cdnas for type iv collagen and laminin b chains have been isolated . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
55,
72
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
190,
206
]
} |
when the muscle proteins were expressed per 100 mg of muscle , the obese rats had lower concentrations of all three muscle proteins , with a greater loss of sarcoplasmic proteins than the nonobese rats at 8 and 52 weeks of age . | tissue_is_expression_site_of_gene_product | {
"id": "C0026845",
"name": "muscle",
"pos": [
9,
15
]
} | {
"id": "C0026832",
"name": "muscle proteins",
"pos": [
116,
131
]
} |
immunocytochemical investigations on the pituitary hormones of the pars distalis of the japanese quail reveal five types of secretory cells , adenocorticotropin ( acth ) cells , prolactin ( prl ) cells , thyroid-stimulating hormone ( tsh ) cells , growth hormone gh ( sth ) cells , and fsh/lh ( gonadotropic ) cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "pituitary",
"pos": [
41,
50
]
} | {
"id": "C0040160",
"name": "thyroid-stimulating hormone",
"pos": [
204,
231
]
} |
studies on partially purified chicken hypothalamic luteinizing hormone releasing hormone ( lhrh ) utilizing chromatography , radioimmunoassay with region-specific antisera , enzymic inactivation , and chemical modification established that the peptide is structurally different from mammalian hypothalamic lhrh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
38,
50
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
306,
310
]
} |
nuclear progesterone receptor is localized in many neurons throughout the hypothalamus but is absent from lhrh neurons . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
74,
86
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
106,
110
]
} |
no receptors for 5ht were demonstrable in the anterior pituitary gland , showing that the prolactin-releasing activity of 5ht must be mediated by a prolactin-releasing factor ( prf ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "anterior pituitary gland",
"pos": [
46,
70
]
} | {
"id": "C0033371",
"name": "prolactin",
"pos": [
148,
157
]
} |
responsivity to photostimulation in previously photorefractory european starlings is caused by subjection to short daylengths and is characterized by a marked activation of the hypothalamus in terms of synthesis of gonadotropin releasing hormone . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
177,
189
]
} | {
"id": "C0023610",
"name": "gonadotropin",
"pos": [
215,
227
]
} |
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