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"To perform image-to-image translation from multi-modal CT perfusion maps to di usion weighted MR outputs To make use of generated MR data inputs to perform ischemic stroke lesion segmentation." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"There is no detail on qualitatively visual comparison of generated MR to ground truth" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"The gain using CGAN MRI looks marginal, which would be better to apply ablation study ." "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'non']" "paper quality"
"It is the first work to identify aortic value prosthesis types using a general representation learning technique." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"This work has a remarkable clinical value" "['pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro']" "paper quality"
"The introduction part is a little misleading for me" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"The authors emphasize that the objective is to cluster the geometric shape of leaflets, and it is hard to represent the shapes in high-dimensional space (last paragraph of introduction)." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"I'm concerned that this would make the readers misunderstand the data are shape-models (point cloud dataset) before the description of dataset in Sec. 2." "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"The experiments shown in Table 1 compare several different network settings." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"This kind of vertical comparison is insufficient to support the claims made in the study" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"Please compare to other representation learning methods such as sparse coding (e.g. spherical K-means, dictionary learning), dimension reduction (e.g. PCA, t-sne)." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"The experiments measure the recon accuracy." "['non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"However, recon accuracy highly depends on decoder network." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"It is not convincing to claim that the clustering is correct since even a noise can be decoded into a normal image" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"In the last paragraph of the introduction, authors say 'it is hard to define a feasible metric describing the similarity of the valve shape in general.'." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"However, authors use Jaccard coef." "['non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"and Hausdorff distance to measure the recon accuracy between original image and reconstructed image." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"other comments: - The authors use 2D images to represent leaflet shapes, I'm concerned whether 2D photograph is precise enough" "['non', 'non', 'non', 'non', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"3D scanner such as CT, MRI, optical scanner could be more suitable for this work" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"Though this is not the issue to be considered in this work." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"The paper is not well organized" "['con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"The hyper-parameters of autoencoder and the recon decoder should be more clearly stated for reproducibility" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"All architectures listed in Table 1 should be stated clearly in experiments section not only in method section ." "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'non']" "paper quality"
"The clinical value of CM images has been highlighted in previous work, but although effective towards the goal of detecting the presence of cancer, these images are hard to interpret by humans." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"The authors propose to use a cycle-GAN to shift the distribution of CM images towards more standard H&E images which are easier to interpret." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"It has the potential to improve pathology and cancer diagnosis by making it simpler and quicker The results of this work look visually convincing" "['pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro']" "paper quality"
"Both the de-speckle network and the GAN appear to deliver very good results, at least at first glance" "['pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro']" "paper quality"
"The study has potential and could have interesting applications in clinical settings" "['pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro']" "paper quality"
"I understand that the available space is limited and therefore it's difficult to bring in the paper all the information that would be necessary, but the introduction should be extended to include previous work both in terms of DL and medical research" "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"The contribution is therefore incremental, building on top of well-known techniques" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"After the publication at MICCAI 2019 of the work ""Distribution Matching Losses Can Hallucinate Features in Medical Image Translation"" and similar other works, it has started becoming apparent that the simple visual similarity between samples generated by a GAN and true samples from a specific distribution doesn't ensure that diagnostic value is kept." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"This doesn't mean that cycle-GAN type of techniques are not suited for medical imaging since they might wipe out their diagnostic value, but it means that every study around this topic needs to prove that the diagnostic value is indeed kept!" "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"Unfortunately the authors didn't report indications in this sense in their paper" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"The main contribution of the paper is scarcely justified by the statement ""...they confirmed that the images were similar to those in routine""" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"I feel it would have been extremely interesting to evaluate the performance of those same clinicians (and others) diagnosing cancer using both H&E stained image and CM images of the same patient (or patient distributions) vs a control group." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"A lengthy study, I agree, but a necessity in light of other recent works highlighting how dangerous is to use GANs for this kind of tasks" "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"Is there some reference for multiplicative residual connections" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"How do we know that the network is learning 1/F (inverse of speckle noise)" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"It is necessary to prove that the generated images retain their important diagnostic value" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"It is necessary to run a study to confirm that in a similar way that CM images were confirmed having diagnostic value and could therefore be used instead of H&E stained images" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"The authors combine DL and computer vision methods to digitally stain confocal microscopy images to generate H&E like images." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"The aim for this work is to provide an image that is familiar to the pathologists such that it will remove the need for specific training for CM interpretation." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"2- Two step approach combining despeckling and generative networks are reasonable for the task" "['non', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro']" "paper quality"
"Error measures presented in Table 1 needs to help readers to identify the benefit of the proposed neural network" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"The authors should validate their selection of two step approach (NN + filter) compared to an end-to-end FCN (with an additional loss like TV) for the despeckling network" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"Even though it is mentioned by the authors that these images resemble to noisy RCM, this should be either referenced or shown" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"For example, it is not clear what are the non-desirable artifacts, where are the eliminated nuclei and why the network has a harder time to learn" "['non', 'non', 'non', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"In addition, images representing eliminated nuclei using noisy RCM images should be presented with their counterpart using despeckling network" "['non', 'non', 'non', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"5- Obtaining quantitative comparison results for staining accuracy is not feasible due to the reasons clearly defined by the authors" "['non', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"It is necessary to provide more qualitative information regarding the staining results in addition to confirmation from two expert pathologists" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"