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"The presented evaluation is limited , with training done on only 8 datasets, which in this particular case is a limitation due to the importance of presenting the networks with different backgrounds from various surgical sites and perspectives during surgery." "['con', 'con', 'con', 'con', 'con', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"A more complete evaluation with different surgical scenarios would be needed to demonstrate this feature." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"Quantitative assessment is fairly limited, and yielding underwhelming results compared to individual networks (ex. CycleGAN)." "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"It would be interesting to have the author's point of you on the less than optimal results, and how they plan to improve it." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"The authors present a deep learning method for fundus image analysis based on a fully convolutional neural network architecture trained with an adversarial loss." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"This is important when processing these images, where anatomical and pathological structures usually share similar visual properties and lead to false positive detections (e.g. red lesions and vessels, or bright lesions and the optic disc)." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"The adversarial loss allows to leverage complementary data sets that do not have all the regions of interest segmented." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"Thus, it is not necessary to have all the classes annotated in all the images but to have the labels at least in some of them." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"The contribution is original in the sense that complementing data sets is a really challenging task, difficult to address with current available solutions" "['pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro']" "paper quality"
"The strategy proposed to tackle this issue is not novel as adversarial losses have been used before for image segmentations." "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"However, it is the first time that it is applied for complementing data sets and have some interesting modifications that certainly ensures novelty in the proposal" "['non', 'non', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro']" "paper quality"
"The paper is well written and organized, with minor details to address in this matter (see CONS)." "['pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"Taking this into account, I would suggest the authors to incorporate at least one paragraph in Related works (Section 2) describing the current existing approaches to do that." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"It is not clear from the explanation in Section 3.1 how the authors deal with the differences in resolution between DRIVE and IDRID data sets" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"The segmentation architecture does not use batch normalization." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"The vessel segmentation performance is evaluated on the DRIVE data set." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"I would suggest to incorporate results on at least one of these data sets to better understand the behavior of the algorithm on these images." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"The area under the ROC curve is not a proper metric for evaluating a vessel segmentation algorithm due to the class imbalance between the TP and TN classes (vessels vs. background ratio is around 12% in fundus pictures)" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"I would suggest to include the F1-score and the area under the Precision/Recall curve, instead , which have been used already in other studies (see [1] and [2], for example, or Orlando et al. 2017 in the submitted draft)." "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"To the best of my knowledge, it has the highest performance in the DRIVE data set compared to several other techniques." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"That would be equivalent to assume that the new data set(s) does (do) not contain the annotations, and will allow to quantify the performance there." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"Since the HRF data set contains images from normal, glaucomatous and diabetic retinopathy patients, I would suggest to use that one." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"A similar experiment can be made using other data sets with red/bright lesions (e.g. e-ophtha, pseudo-url) or optic disc annotations (e.g. REFUGE database, pseudo-url)." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"I think this is a key experiment, really necessary to validate if the method is performing well or not" "['non', 'non', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"The abstract should be improved" "['con', 'con', 'con', 'con', 'con']" "paper quality"
"The first 10 lines contains too much wording for a statement that should be much easier to explain" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"ii) Learning to leverage the information of complementary data sets is a challenging task." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"iii) Explanation of the method... [1] Zhao, Yitian, et al. ""Automated Vessel Segmentation Using Infinite Perimeter Active Contour Model with Hybrid Region Information with Application to Retinal Images.""" "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"Imaging 34.9 (2015): 1797-1807." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"2] Maninis, Kevis-Kokitsi, et al. ""Deep retinal image understanding.""" "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"International Conference on Medical Image Computing and Computer-Assisted Intervention." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"The paper is well written and describes an interesting and relatively novel approach to solving multi-class classification in a clinical domain where overlap between classes is frequently a possibility" "['pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro']" "paper quality"
"The approach is clearly explained and the results presented are sufficient to give merit to the idea" "['pro', 'pro', 'pro', 'pro', 'pro', 'non', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro']" "paper quality"
"The authors could spend a little more effort on explaining the intuition behind conditional versus unconditional labels and the advantages of each" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"Only a single (large) dataset is used, while there are many publicly available datasets that could be included for additional experiments" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"The authors consider the problem of nuclei detection, and propose to decompose the task into three subtasks, trying to predict the confidence map, localization map and a weight map." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"I think the effort of disentangling a complicated task into simpler ones makes sense , and the experiments have shown promising results" "['pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'non', 'non', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro']" "paper quality"
"In my view, the proposed methods are not completely novel , I think the authors are suggested to cite them, just name a few." "['non', 'non', 'non', 'non', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"Predicting the confidence map with fully convolutional networks was initially done by : ""Microscopy Cell Counting with Fully Convolutional Regression Networks"", W. Xie, J.A." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"Noble, A. Zisserman, In MICCAI 2015 Workshop." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"The paper is very well written and easy to follow ; figure 1 does an excellent job at summarizing the method" "['pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'non', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro']" "paper quality"
"Those maps are used for training with a partial cross-entropy." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"The best combination (both labels + CRF) are close or on par with full supervision." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"Do you have any ideas in mind ?" "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"Could it be extended to work with only a fraction of the nuclei annotated ?" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'non']" "paper quality"
"Minor improvements for the camera ready version, in no particular order: Tang et al. 2018 was actually published at ECCV 2018, the bibliographic entry should be updated." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"Section 2.3 should make the differences (if any) with Tang et al. explicit" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"Those three papers should be included in the state-of-the-art section : - Constrained convolutional neural networks for weakly supervised segmentation, Pathak et al., ICCV 2015 - DeepCut: Object Segmentation from Bounding Box Annotations using Convolutional Neural Networks, Rajchl et al., TMI, 2016 - Constrained-CNN losses for weakly supervised segmentation, Kervadec et al., MIDL 2018 Since the AJI and object-level Dice are not standard and introduced in other papers, it would be easier to put their formulation back in the paper, so the reader does not have to go look for it." "['non', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"Replacing (a), (b), ... by Image, ground truth, ... in figures 2, 3, and 4 would improve readability." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"To investigate whether a conditional mapping can be learned by a generative adversarial network to map CTP inputs to generated MR DWI that more clearly delineates hyperintense regions due to ischemic stroke." "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"