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iam 33 yrs old.i have 7yrs boy. my problem is my husband is staying in u.a.e.we are trying for second baby whenever he comes for vacation.he will stay for 2months only .iam not getting pregrany.wat is the reason.please give me suggestion
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The relationship between immunity and nutrition is well known and its role in coronavirus disease 2019 (COVID-19) is also being paid great attention. However, the nutritional status of COVID-19 patients is unknown. Vitamin B1, B6, B12, vitamin D (25-hydroxyvitamin D), folate, selenium, and zinc levels were measured in 50 hospitalized patients with COVID-19. Overall, 76% of the patients were vitamin D deficient and 42% were selenium deficient. No significant increase in the incidence of deficiency was found for vitamins B1, B6, and B12, folate, and zinc in patients with COVID-19. The COVID-19 group showed significantly lower vitamin D values than the healthy control group (150 people, matched by age/sex). Severe vitamin D deficiency (based on a cut-off of ≤10 ng/dl) was found in 24.0% of the patients in the COVID-19 group and 7.3% in the control group. Among 12 patients with respiratory distress, 11 (91.7%) were deficient in at least one nutrient. However, patients without respiratory distress showed a deficiency in 30/38 cases (78.9%; p = 0.425). These results suggest that a deficiency of vitamin D or selenium may decrease the immune defenses against COVID-19 and cause progression to severe disease. However, more precise and large-scale studies are needed.
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My 14 yr old son had an injury to left knee. Went to Erie got immobilizing brace and crutches. Followed up with orthopedic dr. Ordering an MRI , my sons foot and calf are significantly colder than the uninsured leg. Should I be overly concerned ? Should I mention to dr office in the morning?
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What is suggested on histology by the presence of large nuclei with eosinophilic nucleoli and numerous mitotic figures?
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Hi doctor, During masturbation I just rub the tip of the penis and not the entire penis. Is it a wrong way of doing? I do not get excited during sex and unable to ejaculate. Only, rubbing the tip of the penis gives me excitement. Also, two weeks ago, I have undergone circumcision as my foreskin did not retract. Before circumcision too, I have the same problem. Please help.
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I have a slight problem around my penis area. For around 2 weeks now, I have been getting quite alot of pain around the base of the head of my penis. Before and during sex. Once my foreskin is pulled back where the skin rolls up I have been getting small cuts kind of like paper cuts but a little wider around the outside of my penis. These cuts are quite painful and sting quite alot. They heal after a week of no masturbation or sex. But the the skin becomes very very tight and once i try to pull back / or my foreskin comes back these cuts break through again ( like cracked lips) and the area becomes quite swelled and red for a few days
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I'm running my 4 month of pregnancy and since 14th week feeling slightly head spinning and avoidable headache, I'd like to take a proper suggestion without having my medicine or chemical treatment means please advise me Homeopathy or Ayurvedic solution for this.Thanks,Your earliest response awaited...
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I had an infection around a tooth which my dentist extracted on Thursday. I am taking Amoxicillin since then but my lymph node is still swollen and my gum area still appears whitish. The pain has lessened but I just wanted to be sure the infection isn't spreading.
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Hi, may I answer your health queries right now ? Please type your query here... I came off depo provera in feb now I have sharp twinges in my lower right abdomen and I am urinating a lot lore than I used to. I drink about 6 to 8 times a day as always have but wee a lot more, and it's dark with a strong smell. I had diorrhea a few days ago that had white phlem looking bits in it and lately my nipples are erect sometimes without being touched or cold. My boobs have hurt for a few months now too. I took anpregnancy test 2 weeks ago and it was negative. Please help
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What is the case study on Rift Valley fever?
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I have a lump on the right hand side of my neck, just above my colalrbone. It is fairly hard, and about the size of a marble. I just found it a week ago, so no idea how long it has been there. It definitely isnt getting any smaller. It is not painful. Any ideas?
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Hi, A few months ago the wire from my bra was digging in under my arm and a small lump appeared I didnt think much about it and stopped wearing that bra but over the last couple of weeks the lump has gotten bigger and is now very red and sore to the touch, should I go to the doctors to get it checked
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ABSTRACTwWe use the urban political ecology perspective to explore how communities of homo religiosus (re)configure politics of COVID-19 in India and Pakistan. This urban health crisis unfolds in five parallel registers of conflictualities: (i) where religious communities carve out a domain for self-governance of the pandemic with their own ‘knowledge and truths’, (ii) where embodied religious practices challenge or undermine state biopower and transform governmentalities, (iii) where the spatial dimension of conflict evolves into the crisis of technologies of governance, (iv) where religious identities are stigmatized and the minority groups are excluded and (v) where communalism organizes around international relations. It is argued that religious groups in South Asia influenced the urban political (eco)pathology with their disruptive potential which transformed biosecurity regimes and enhanced health risks on the one hand and on the other, they embraced and internalized discords of disease within their antagonistic communal and sectarian memories and histories and weaponized the pandemic to produce more cracks in the social fabric. This essay underscores the significance of unusual actors in the urban political ecology framework and calls for a renewed understanding of human–nature interface by incorporating religion and religious beliefs and how they view and shape the metabolic flows in the urban spaces for social sustainability of the city as a ‘natural object’.
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I have PCOS and trying to conceive my partner and I have had two regular cylcles and we had intercourse through the whole ovulation Period last month I normal have PMS symptom 1/2 weeks before my period is due but this month i have had nothing but clear discharge and bloating and my period is 10 days late and negative tests? could i be pregnant?
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COVID-19 poses a great challenge to clinical and diagnostic services around the world. The need of biosafety practices can never be emphasised more than under current circumstances. The four pillars of biosafety namely, leadership, standard operating procedures, personal protective equipment (PPE) and engineering controls must be employed for effective and safe practices in the clinical setting in general and laboratory settings in particular. Risk assessment must be carried out before meeting up the diagnostic challenge for COVID-19 and essential biorisk management measures are required to be taken. In our resource-poor settings, we need to adapt safe but cost-effective and improvised solutions to ensure safe handling of clinical samples from COVID-19 patients in the laboratories. The correct use of PPE and their suitable alternatives are available for selection and use. Disinfection of the lab areas and safe disposal of the clinical samples from such patients is also of paramount importance.
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i have typoid fever and feel always shivering how to controle i have been prescribed ciprofloaxin 500 mg tab daily morning and evening and paracetamol and ceftriaxone iv 2 times daily for 5 days, even after 2days of treatment still i am suffering fromshivering, Plz advise me
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Sir, Want to know if we have any treatment for the mass growth on liver. My grandpa is suffering with this condition and is arond 75 years.His condition is getting bad day by day and the local doctoirs have given some medication but do not suggest any surgery. Is it possible at this age and what are the best hospitals in India particlarly pune to address same. Hoping to hear you soon. regards, Meenakshi
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Hi Doc! My C-reactive protein as per fasting blood sugar is positive (96) Ref. range 0-6 mg/lt (qualitative method). My Vitamin D is 5.90. Erythrocyte sedimentation rate is 63 ( Ref. range 0-20 mm at the end of 1hr.) as per Westerngren method. I was admitted on 24th oct. to hospital with symptoms of difficulty in walking, joint pain, swelling, fever. The x-rays showed synovitis of the feet etc. The test for chikungunya came negative. I am on a lot of medication like eezflam, sompraz, trinerve, uprise D-3, Kalzin -c, ostium - kz, supanac 50mg, calpol 650 mg, becozinc, limcee. I have been told to repeat the test for chikungunya tomorrow 13.11.11. I am 39 yrs old. I have been told I have rheumatoid arthritis and severe D-3 deficiency. I am also onto physiotherapy. I want to know whether I would ever be able to lead a healthy life and how I can get back to normal routine. I am a working woman with two children.
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Should I be overly concerned that I was told yesterday by the medical clinic I visited on Thursday evening that I am actually fhave a MRSA infection, not a regular Staph infection. A week ago I went in for a few ingrown hairs in my left arm pit and one in my lower abdomen. The largest on in my left arm pit was opened, drained, cleaned, and packed.On Thursday evening, I was given a prescription for Bactrim and told to take 1 pill 2 times a day.I went in again on Saturday for the packing to be removed and 2 was told it looked like it was doing well. I was told the intentional lab results indicated it was Staph, but it would be cultured in the lab..Sunday evening the bump on my abdomen, which had been puffy and a bit red, started oozing and got pretty bloody. There was also a dark pinkish oval on my skin around it.So I went to the only urgent care clinic open on Labor Day in our small town. The PA I saw lanced it, cleaned, it and packed it. He was concerned and thought it looked more like MRSA and was surprised this had happened as I had been taking Bactrim for 4 days. So he recommended I start taking 2 pills, 2 times a day. I went back on Wednesday to have the packing replaced. Today I noticed the pink/red oval on my skin around the abscess on my lower abdomen. Does this mean the Bactrim is not working. What do we do then? I go back to the clinic tomorrow to have the packing on this one changed.Thanks! Jan
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What is the purpose of performing a CT or MRI of the chest in patients with a diagnosis of myasthenia gravis?
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I have been going thru allergy test. In the food line it was determined that I am allergic to yeast. I know that yeast is in bread and soy sauce. From what I read in your article it seems like yeast is in everything. So now how can I know what I can take and eat?
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Hi, I have a hard lump on right side next to tailbone and started feeling pain Mon. afternoon. My tailbone was painful but been taking tylenol and the pain is more dull. I still can t sit back or lay on my back. I only remember sitting in a car for 2 hours on a day vacation this Sat., slept on a hard mattress Fri. evening, and bumped my bottom when making the bed Friday evening.
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Good evening. Have been experiencing severe dry coughing, shortness of breath, sneezing, mucus buildup, hot/colds ( though those have lessened today) and as of today significant aching and tingling pain throughout my back and core or trunk area. Thought it was a flu, but doesn t seem to be lessening and it s been 6, going on 7 days now.
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Hi ....I am xxxxxxx basically belongs from Sitapur, U.P.; I consults with lots of Doctors in last 15 yrs but didn't get any proper result, As per doctors detail my uterus and tubes are covered so not seen properly & in uterus some parts are blocked but my periods is normal.
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After 3 years of my relationship i had a breakup with my boy friend. and now I don t know how to move on in life since last six months I ve been depressed like hell... Can t even concentrate on my work.. I can t even like anyone forget bout love.. dun knw wt to do..
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I have a lump under the skin on my chin. I noticed that it got bigger. Then there was another small lump next to it, now I found more small lumps on the right side of my face at the chin line every day they seem to get bigger. I don t know what to do.
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During the day today I developed a red patch on my gums. It's darker than my gums. It does not hurt. It is not swollen or bleeding. I have very heathy teeth and gums. I go to the dentist 2xyr. Should I call the dentist and get an appointment? Thank you!
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What is the role of hypoxia-inducible factor 1α on renal fibroblasts and what mRNA does it cause synthesis of?
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Hi doctor, I am a 26 year old male. I am 5 feet and 9 inches tall and weigh 255 pounds. When I eat spicy food, I poop blood. Sometimes when I have constipation as well, I poop a little bit of blood. I am really scared that I have colon cancer. I do have diarrhea often. I do not have a family history of colon cancer. I got blood tests done last night. Please find my reports attached.
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What is the association between exposure to a certain substance in utero and the incidence of vaginal adenosis in females?
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a friend of mine was admitted almost two wks ago w/a problem falling down. scans show lesions on brain and kidney . her heart is too weak to do a tissue sample of the brain...does this sound like cancer? She is still in hospital...a FNA of liver was done yesterday. Just a general answer would be nice. She has not been told what is wrong or suspected.
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What other imaging findings are commonly associated with Lymphangioma?
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Hi I am Rajesh & for the first time i am facing problem while passing urine & i have under gone x ray , urine test , blood test . x-ray says there is no stones in the kidney , after that doctor directed me to take more water & KMG cit to mix in the water & have 3 times a day & two types of tablet which are meftal spas , OMTECH D. after taking these medicenes i am experiencing loose motion please adivse the action to be taken.
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Hi, I have asthma and play a lot of soccer throughout the spring. I also have seasonal allergies. However, I have been sick multiple times in the past month or two and now, I feel like I am getting worse. I have a pain in my lower right back that increases when I breathe or cough. I had strep 2 weeks ago, but my newest sickness is not strep. I had a fever last Thursday. It is becoming really hard for me to breathe even using my inhaler twice a day. It is also beginning to hurt my lungs and throat even more when I use my inhaler, and the lower back pain just gets worse throughout the day. Please help!
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I have a 39 year old son, who 6 weeks ago had a lower wisdom tooth removed. He now has bad painin his lower front 2 or 3 teeth and sometime only one and under his tongue. sometimes tip of tongue burning.he has been back to dentist twice, and to 2 oral surgeons, one numbed his front teeth, and alvorie and lingualnerve to try to find out where pain was coming from, he hit the lingual nerve with needle, said it was up higherthan normal, said the alvore nerve looked ok from x ray, Cant find any one to diaganose problem with mri or anything, no one knows what to do, other than give pain killers, ambient to sleep, steroids, he still cant sleep for the pain.Help!
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hi. I am 18 years old and I had acne before a month now I am free from acne but left with red marks. My doctor advisedd me to use kojic acid cream but i dont think am getting satisfoctory results. please help.
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Yesterday I had an anaphylactic reaction to pine nuts. I realized as a young adult that I was allergic to them. Yesterday was by far, the worse reaction ever. Swollen face, tongue, and a restricted airway, as well as severe itching all over. It was also the first time I had to have a shot of epinephrine. I also had 2 steroid shots, as well as dyphenhydramine. I was told to continue Benadryl for 3 days. My question...what should I expect over the next few days? Of course, I m tired, but have a terrible headache today. My face is also flushed and hot. Thanks so my much!
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my 22 year old grandson has low back pain, lumbar radiation around, and limping. He is active at football and basketball. His doctor mentioned a possibility of ankylo spondylosis and some blood tests to check for a gene which might be involved. Please explain whaat this might mean. thank you
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I took 50 mg of diclofenac 2x a days for a year. No problems. My hip pain became severe and I resumed the diclofenac along with 4 g of voltaren gel one day x2. Went to bed & 6 hours later i awoke swollen, red all over. Clearly an anaphylactic reaction. Took benadryl which quickly subsided the symptoms. Now I m concerned that I may be allergic to diclofenac. Or could it be a reaction to just the voltaren? I called Novartis. They were no help & didn t really have any interest in recording my information regarding my reaction. Although I insisted they take it. My MD has just retired and I m in the process of finding another. Any suggestions? Thank you. kind regards, elaine
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i had my last depo shot nov 2011 and have been trying for a baby since my periods are usualy regualar and last around 5 days and usualy very heavy day and night this month i had a bleed 3 days late and only heavy for one day no bleeding at all during the night, but 3days of scanty on and off pink/bright red blood , is there a possibility i could be pregnant and when to take a test?
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Any strategy to mitigate climate change will have economic and political implications that are incompatible with libertarian ideals of free markets These political implications have created an environment of rhetorical adversity in which disinformation is systematically disseminated by a variety of politically and economically motivated actors who seek to delay or defang climate policies I review the strategies of climate denial and how they fit within an historical arc ranging from denial of the adverse health effects of tobacco to the denial of facts and policies involving the COVID-19 pandemic I review communicative countermeasures and conclude by pointing to the necessity to examine whether science denial is a necessary implication of libertarianism or whether it can be reframed to become an ally in climate mitigation and public-health policies
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2 days back my baby (2 yrs) had fever and we gave her calpol syrup. But still she was having high fever. With consultation with a local doctor we gave her the Amoxylin oral suspension (Fightox) and her fever has gone. But she has gone lean and now became little bit inactive.
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hello mam, m a 24 years old married woman,, want to know about my pregnency.. my wait is increasing continuosly, too much fat is deposited on my abdominal region as well as on my thies..i m a 5feet 3 inches tall .earier my wait was 55kg now it has been increased upto 65 kg m very tensed.please answer whether i need to take a baby by operation or will it be a normal delivery..shall i concieve baby after loosing wait to avoid operation??
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I have a bump or lump on the side of my index at the first joint. It’ s hard, sensitive and warm. I thought it was a bone bruise but, it’s growing slowly. Also I have a lump in the palm that is tender and cording growing. Thank you. XXXX
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my sister has stage 4 lung and matasis brain cancer for 6 yrs her doctor said no more chemo because she now has neuropathy and cant walk without assistance he said no drug would help accept homeopathic Bs she has taken for a month no help now her seizure doctor has put her on neurotin on it a weed is there anything else we can do to speed her progress up she has physical therapy twiced a week her feet feel like there falling out from under her and unbalanced and has fallen several times
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I am on a pain pump and 4 oxycodone -APA Sorry missed the right key Oxycodone -APAP 10-325 tabs 4x a day. I am looking to get off the pain pump and eventually the oxycodone. My question is what over the counter pain reliever will work in their place ? I have a bad scoliosis that is affecting me with lots of pain, and Lupus.
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Cavanagh et al (2002) found 1 field vole with advanced TB to have had all of its lung lobes containing tuberculous nodules of up to 10 mm in diameter.
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Hi there, I have had some history of Acidreflux for the past 2 years. However, recently, after taking some medication, i have recovered from the problem. During this time I have developed lower back pain and am not sure if it is linked to acid reflux. The back pain is usually present when i wake up in the morning, and especially if I am sleeping on my back. I also get numbness on my lefthand and left leg at certain angles if lay on my back. The pain however goes away once i stand up and go about my daily activities. I also have a suspicion that my bowel movement is also being affected by this as my stool is now flaky and is in small chunks. Does this mean that I have injured my back or is it connected to me not fully recovering ffom acid reflux? Thanks
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As agendas for data-driven measures of excellence dominate policy in UK Higher Education (HE), we argue that the generic structure of national policy frameworks virtually silences regional voices. This furthers a territorially agnostic discourse about universities, downplays institutional history and purpose, risks concealing innovative practices, and fails to tackle entrenched inequalities. In response, we point to the value of live, place-based debate in HE institutions to highlight distributional inequity, raise local voices and connect these with national policy. Yet even as we compiled this article about HE debate, the Covid-19 pandemic took hold globally, cancelling face-to-face meetings, by necessity. We therefore draw on a postdigital perspective, as we share our individual dialogues in support of debate, via collective writing, against this new backdrop of social distancing and widespread uncertainty. We may not currently be able to convene our Midlands HE Policy Network (MHEPN) debates in person, but we can voice the essential part that regional universities play in connecting global technological and biological change, with local social projects, citizens and industry. Postdigital theory offers one route to understanding that Covid-19 does not sit apart from other political economic challenges in HE and beyond, that we need to debate simultaneously.
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What causes Ecthyma?
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hi Doctor, My daughter is six years and is diagnosed with Typhoid fever. she has low grade fever for the past 2 weeks and is on antiboitics and other medicines namely Ventrolin, Clavam Forte, Azee 200 and polybion. In how much time she will be alright.
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Hi I just underwent a Frozen embryo transfer on the 10 of December.My doc advised me Susten Vaginal Tablets 400 mg 4 times a day.I dont recollect if I have taken the 3rd dose today or not. Will that be a problem? I did day 3 transfer.Pls help as I am really worried.thanks,Hema
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hello doctor i m soni 29 yr old female, i have pain in my left side of whole body from head to toe from last 9 yrs, always my left eye is swelled , n temp. difference , cold on left side, most of the time i feel itchy on my left side of body, i ve done neck x ray a week ago, there is a cervical rib present on my both side, i had birth trauma on my left side of head. last year i done a brain mri also , impression is bilateral fronto-parietal subcortical n left parietal deep white matter / centrum semivale-T2W/ flair hyperintensities. n last week i ve done blood test ESR =44. i m fed up from this terrible pain all the time. please help me.
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I fell down on my right side, and feel lots of pain. Hard time taking big breath, painful when i cough, or try to push stool. I fell two days ago. I have been taking Motrin over the counter,and it helps a little, not much. I have some Robaxin , which they tell me is stronger for the pain. I need to block the pain so I can move easier and heal. I have to be able to lift a minimum of 40 lb. for my job, and I can not right no with the pain. I m 63 years old, and very active. Is there some other medication I could take that is strong like Robaxin.
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What ventilator setting change is best to improve respiratory alkalosis in a 70 kg patient with the following settings: FiO2: 40%, PEEP: 5 mmHg, VT: 450 mL, RR: 18/min?
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So I was eating a bowl of cereal and I felt some thing dangling at the back right of my mouth and when I looked in the mirror it was a peice of my gum still attached just hanging there. It does not hurt at all it is bleeding a little. What should I do I'm a little scared!!!
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BACKGROUND: The COVID-19 pandemic has caused radiotherapy resource pressures and led to increased risks for lung cancer patients and healthcare staff. An international group of experts in lung cancer radiotherapy established this practice recommendation pertaining to whether and how to adapt radiotherapy for lung cancer in the COVID-19 pandemic. METHODS: For this ESTRO & ASTRO endorsed project, 32 experts in lung cancer radiotherapy contributed to a modified Delphi consensus process. We assessed potential adaptations of radiotherapy in two pandemic scenarios. The first, an early pandemic scenario of risk mitigation, is characterized by an altered risk–benefit ratio of radiotherapy for lung cancer patients due to their increased susceptibility for severe COVID-19 infection, and minimization of patient travelling and exposure of radiotherapy staff. The second, a later pandemic scenario, is characterized by reduced radiotherapy resources requiring patient triage. Six common lung cancer cases were assessed for both scenarios: peripherally located stage I NSCLC, locally advanced NSCLC, postoperative radiotherapy after resection of pN2 NSCLC, thoracic radiotherapy and prophylactic cranial irradiation for limited stage SCLC and palliative thoracic radiotherapy for stage IV NSCLC. RESULTS: In a risk-mitigation pandemic scenario, efforts should be made not to compromise the prognosis of lung cancer patients by departing from guideline-recommended radiotherapy practice. In that same scenario, postponement or interruption of radiotherapy treatment of COVID-19 positive patients is generally recommended to avoid exposure of cancer patients and staff to an increased risk of COVID-19 infection. In a severe pandemic scenario characterized by reduced resources, if patients must be triaged, important factors for triage include potential for cure, relative benefit of radiation, life expectancy, and performance status. Case-specific consensus recommendations regarding multimodality treatment strategies and fractionation of radiotherapy are provided. CONCLUSION: This joint ESTRO-ASTRO practice recommendation established pragmatic and balanced consensus recommendations in common clinical scenarios of radiotherapy for lung cancer in order to address the challenges of the COVID-19 pandemic.
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Hello. My father is 80 years old. Hx-HBP, Diabetis 2, Ileus x 2,SVT,squamous places removed from face,back. RE: Tonsil and lymph squamous cancerLump on neck appeared 3 days after removal of squamous places on face. Symptoms of vertigo, weakness, heart rate 50. BP? Trip to ER and was admitted. While being treated for these symptoms, lump on neck became an issue. BX revealed squamous. Neck PET - tonsil cancer. Surgeon removed cancerous tonsil. "Cleaned out" lymph glands. He is to start radiation.Do doctors check to see if cancer has spread to other areas before starting radiation on tonsil area?Thank you.Best regards,Concerned Daughter
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I have been told I have hemocromostis because my ferritin levels are high..my second dr said no...how do I know if I in fact have it..is there a special test I can have to prove it...one dr said it is genetic but want to know how she came to that conclusion
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hello sir,i had frenuloplasty 21 days ago. but stitches on glans part are stil there. how much time they will take to dissolve fully????? and when i retract my foreskin sometimes it does not com e back easily nd become like paraphimosis. should i go for circumcision also????
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i am expiriencing light heavy breathing although i can breath normal i can feel it a little haevy and every ounce in awhile i take a heavy breath for confort when i sleep on my side i can breath good worse when i sleep on my back i even feel like my stomach is full when ive only eatena little im 240 in wieght but iv been that for awhile and never felt like thisis there anything i can do
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I have a patch of small bumps on the upper arm and a small patch on top of my shoulder. Arm is sore to the touch down to elbow. No other pain, not hot or discolored. No recent sports or other injuries occurred. A few of the bumps have small white heads on them. I have no other health issues, take no medications.
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dear sir , i got married 3 years completed. idont have baby , i went hospital a lot of medicine i will take, since now i will use sitha medicine dr say pcod , i took medicine, he will say pcod clear , this month you are try to conceive , please help me
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Hi I am a 42 year old male. In the past month I have noticed that when I defecate a white, very, very sticky substance comes out of my penis. It is usually is I am slightly constipated and have to push. Initially I thought it might remnants of semen in my penis but it is much stickier. Any ideas? Simon
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Can you provide a description or summary of cysticercosis?
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Ralph has always been different from his classmates. When he was in fourth grade, he still could not add or subtract numbers larger than 10. He had trouble reading and spelling the simplest words. His memory was poor. All of the kids constantly teased him and called him names. Finally his parents sent him to a special school. When he got to seventh grade, he had to take gym. After the class all of the boys had to take a shower. Once again the teasing and the tormenting started for poor Ralph. The other boys told him he looked like a baby and that he would never grow up to be a real man! When he got home, his mother tried to comfort him. Things just continued to get worse. Ralph kept gaining weight and the nickname “Tubby” was given to him by some cruel classmates. Still another problem was that Ralph was at least a foot shorter than other boys his age. What was Ralph’s problem?
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My last period was on 8-20-13. I had sex on 9-1-13. I ovulated on 9-3-13. Im also on birth control pill. I have been extremely nauseated, feeling light headed and dizzy, left pain of and on in my stomach, gassy, peering more, and I was constipated but not anymore. I have also took 2 pregnancy test and they were negative. Am I pregnant?
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I ve gotten very mixed results as to whether or not I could be pregnant. I haven t been sexually active since before my last period, but a pregnancy test still comes back as positive. How can I tell one way or the other without having to go for a complete medical exam?
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I am a 66yr old Female and for the last 4 - 5 months have been suffering from neck pain in the right side of my neck which sometimes goes down into my right arm . The pain is always there but is noticably worse when I turn my head either left or right or look up and down. I recently visit my GP who examined me and said that I had a crumbling spine, I have no back pain , and advised me to take paracetamol . What is a cumbling spine and what is the long term prognosis . Can anything be done to help. I was a bit shocked at the time so I didn t ask him those questions. Many Thanks Maggie
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Hi, I suffer from depression/anxiety. I've had feelings of unrealness,racing thoughts,irrational thoughts, I was prescribed 20 mg of citalopram which I take every morning, and I was also prescribed .5 of clonazapem, which is to be taken 1 at morning and 1 in the evening. I didn't take it this morning and I seem to be doing well, I don't feel any side effects, is it a good thing to only take the clonazapem when I'm feeling horrible? It's been about 15 hours since I last took the clonazapem. The citalopram I take every morning I won't stop because I know I need it. But can clonazapem be optional for me to take? I know it's a low dosage. Thank you.
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My son 6 and half years old..his cpk range 220 and keep complaining me pain back side of the knee please let me know what would be this? is this any chronic or curable...somehow iam also suffering with fibromyalgia( though iam having pains allover body)..is my kid s cpk levels are related to FM please advice me whom to consult for this,,,,iam so panic...is this Curable? please help me out.regards jyothi
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I am a 50 year African woman still menstruating. I started having this heaviness in my upper right abdomen just under the ribs about 6 months ago. It is on and off especially after a meal. I also feel some pain there and on my right flank when i take a deep breath or move my body. My right ribs are sometimes tender when i press them especially the last one. I am so worried about what it can be. I carried out some blood tests which came back okay except for the ESR which was high (50). I did a CT of the abdomen which was okay except for multiple liver cysts. What do you think?
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BACKGROUND AND PURPOSE Intravenous thrombolysis with rtPA is the standard of care for patients with acute ischemic stroke within 4.5 hours after symptom onset. However, a considerable number of patients are ineligible for IV thrombolysis due to various contraindications. Recent studies have proved the superiority of mechanical thrombectomy for patients with large-vessel occlusions in combination with IV rtPA compared with IV rtPA alone. We aimed to demonstrate the efficacy of mechanical thrombectomy for patients who are ineligible for IV rtPA. MATERIALS AND METHODS Patients from the stroke registries of 4 dedicated centers who were treated with mechanical thrombectomy from January 2010 to October 2014 were retrospectively evaluated. Inclusion criteria were the following: acute stroke due to proved large-artery occlusion, ineligibility for IV thrombolysis, and a timeframe of ≤4.5 hours between stroke and the start of mechanical thrombectomy. Recanalization success, periprocedural complications, clinical outcome, and hemorrhages were evaluated. RESULTS One hundred thirty endovascular recanalization procedures were identified. The locations were the following: proximal ICA in 17 (13.1%), terminus ICA in 25 (19.2%), M1 segment in 77 (59.2%), and M2 segment in 11 (8.5%). TICI 2b/3 results were achieved in 101 (77.7%), and an mRS score of 0-2 in 47 patients (37.9%). There was a significant correlation between TICI 2b/3 results and good clinical outcomes (87.2% versus 6.8%; P = .048). A good clinical result was most frequent when recanalization was achieved within 4.5 hours (37/74 = 50% versus 10/50 = 20.0%; P = .001). Symptomatic hemorrhage occurred in 13.1% of patients; mortality was 24.2%. Periprocedural complications were recorded in 10 patients (7.7%). CONCLUSIONS Mechanical thrombectomy can achieve good clinical outcomes in patients with acute large-artery occlusion ineligible for IV thrombolysis, in particular when recanalization is reached early.
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Hi Doctor,Today we went for a postcoital test though i have not yet pregnant since the last 1 year. The test refers sluggish sperms 3 -4 and dead sperms 15- 20. What will be my problem? and how can I overcome..... Is there any problem with my cervical mucus. We have done this test 4 hours after intercourse.
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How can prolactin impact ovulation and spermatogenesis?
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What are some physical signs that may indicate a child is experiencing physical abuse?
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hi....m shilpa n my age is 22......i had an intake of 28 disprins on friday n nw m nt able 2 hear properly......i feel fainted as i stand....my b.p. is also vry low........i wnt 2 knw dat wat wud happen 2 me nw?????do i need 2 c a doc or gv sm medical advice pls.......my e-mail id is YYYY@YYYY
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I am experiencing pain in my lower left back, beginning when i woke up this morning. At first I thought I slept funny, but stretching my back did not help. It intensified when I put on my pants, but not horrible. Then I attended a 4 hour meeting and just couldn t find a position to alleviate the pain. Sometimes the pain was shooting. When the meeting was finally over, standing and walking was a relief.I have had kidney stones hanging around in both kidknesy for years, wondering if one could be gettting nasty.
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The first cases of coronavirus disease 2019 (COVID-19) were reported in December 2019 and the outbreak of SARS-CoV-2 was declared a pandemic in March 2020 by the World Health Organization. This sparked a plethora of investigations into diagnostics and vaccination for SARS-CoV-2, as well as treatments for COVID-19. Since COVID-19 is a severe disease associated with a high mortality, clinical trials in this disease should be monitored by a data monitoring committee (DMC), also known as data safety monitoring board (DSMB). DMCs in this indication face a number of challenges including fast recruitment requiring an unusually high frequency of safety reviews, more frequent use of complex designs and virtually no prior experience with the disease. In this paper, we provide a perspective on the work of DMCs for clinical trials of treatments for COVID-19. More specifically, we discuss organizational aspects of setting up and running DMCs for COVID-19 trials, in particular for trials with more complex designs such as platform trials or adaptive designs. Furthermore, statistical aspects of monitoring clinical trials of treatments for COVID-19 are considered. Some recommendations are made regarding the presentation of the data, stopping rules for safety monitoring and the use of external data. The proposed stopping boundaries are assessed in a simulation study motivated by clinical trials in COVID-19.
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What happens to the exocytosis of insulin and C peptide when the β cell is stimulated?
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hi, i had blood test results back last week and its came about i have a low platelet count, i have had two tests now and low on both. i am tired and very dizzy almost all of the time, could you tell me a little more please... my doctor has asked me to go back for more tests in two months time, im worried and dont really understand why i have to wai so long. i am a 22 yr old female. i have suffered with panic attack for years too amd feel they are just getting worse, please help. thanking you.
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What is the recommended medical treatment for amoebic liver abscess?
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My 9 year old daughter had fun and fitness day at school today. She was outside in the 80 degree weather until about 2 p.m. About an hour ago (6:39) she started to complain of a headache which became so bad she was crying and then vomited about 30 minutes ago. Could she be suffering from heat exhaustion?
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my partner suffers from delayed ejaculation and only manages to come through his own mastibation, he has been masterbating quite roughly for about 15years, nothing i try eg intercourse seems to have any effect on him, is there anything i can do to try and help my partner to be able to come through intercourse
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Why is it that the day after I take my last antibiotic for sinus infection, my sinus infection is right back and my right eye vision is real blurry, so blurry that I can t see very well out of that eye. This sinus problem in now going on for four years. I ve seen an ENT with no real answers.
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Hi my name is Elise. I am 34 weeks pregnant. And Im having severe hip pain back pain and some times my back will feel sore. Im also having cramping like pains in lower abdomen. Im getting nausea vomiting alot for the last week. And now my belly is feeling weird can you tell me why.
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Hi Good Morning My Mother has blood pressure. She is taking Amlong 5 mg currently from past 5 years. From past 1 year she is experiencing swelling in her both lower legs.Looks like we need to change the medicine. Please advise which medicine to take.
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AIMS/HYPOTHESIS: Variants close to the VPS13C/C2CD4A/C2CD4B locus are associated with altered risk of type 2 diabetes in genome-wide association studies. While previous functional work has suggested roles for VPS13C and C2CD4A in disease development, none has explored the role of C2CD4B. METHODS: CRISPR/Cas9-induced global C2cd4b-knockout mice and zebrafish larvae with c2cd4a deletion were used to study the role of this gene in glucose homeostasis. C2 calcium dependent domain containing protein (C2CD)4A and C2CD4B constructs tagged with FLAG or green fluorescent protein were generated to investigate subcellular dynamics using confocal or near-field microscopy and to identify interacting partners by mass spectrometry. RESULTS: Systemic inactivation of C2cd4b in mice led to marked, but highly sexually dimorphic changes in body weight and glucose homeostasis. Female C2cd4b mice displayed unchanged body weight compared with control littermates, but abnormal glucose tolerance (AUC, p = 0.01) and defective in vivo, but not in vitro, insulin secretion (p = 0.02). This was associated with a marked decrease in follicle-stimulating hormone levels as compared with wild-type (WT) littermates (p = 0.003). In sharp contrast, male C2cd4b null mice displayed essentially normal glucose tolerance but an increase in body weight (p < 0.001) and fasting blood glucose (p = 0.003) after maintenance on a high-fat and -sucrose diet vs WT littermates. No metabolic disturbances were observed after global inactivation of C2cd4a in mice, or in pancreatic beta cell function at larval stages in C2cd4a null zebrafish. Fasting blood glucose levels were also unaltered in adult C2cd4a-null fish. C2CD4B and C2CD4A were partially localised to the plasma membrane, with the latter under the control of intracellular Ca(2+). Binding partners for both included secretory-granule-localised PTPRN2/phogrin. CONCLUSIONS/INTERPRETATION: Our studies suggest that C2cd4b may act centrally in the pituitary to influence sex-dependent circuits that control pancreatic beta cell function and glucose tolerance in rodents. However, the absence of sexual dimorphism in the impact of diabetes risk variants argues for additional roles for C2CD4A or VPS13C in the control of glucose homeostasis in humans. DATA AVAILABILITY: The datasets generated and/or analysed during the current study are available in the Biorxiv repository (www.biorxiv.org/content/10.1101/2020.05.18.099200v1). RNA-Seq (GSE152576) and proteomics (PXD021597) data have been deposited to GEO (www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE152576) and ProteomeXchange (www.ebi.ac.uk/pride/archive/projects/PXD021597) repositories, respectively. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains peer-reviewed but unedited supplementary material available at 10.1007/s00125-020-05350-x.
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i have 1 bump on shaft of penis and it looked like a zit and when i squeezed it, it had a white discharge just like a pimple but it keeps having same discharge and won't go away...any ideas what this might be? I'm 36, 6'1", weigh 180lbs and I'm a single dad that's been dating same girl for 9 months..is this an std? is she cheating on me?
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I rolled my ankle 3 days ago there was a little swelling and bruising, there is a lot of pain along the bone that connects to my little toe and my ankle feels like its burning on the joint . I can t put much weight on it and my toes have been numb for 24 hours. What should I do?
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Dear Doctor, i m 33 years old i have a very bad pain in my back and stomach wich get worse during the night for more than 3 months even i can t sleep after 2 o clock i wake up tell morining when my stomach start to some noise i can sleep ( stomch is geting sowllen and full of gas). kindly assist me. thanks
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I have a hard bony lump on the inside of my mouth on lower jaw. should I request a specialist appointment if my GP does not seem too concerned?I am 64 years young, approx 5 feet 4 inches, about 180 lbs and relatively healthy. past hx ---thyroidectomy and hystorectomy
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I had the flu, H1N1 over 3 weeks ago. I now have severe ringing in the ears, almost constant headaches and waves of pain in my head that get worse at night when I lay down. Had an episode last Sunday where my head and hands were numb and went to the ER. They did a cat scan and some blood work as well as a urinalysis and cannot find anything. The numbness is gone but still having symptoms. I am 49 years old with high blood pressure and high cholesterol.
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hi i got married last year nd 6 months ago my husband faced a accident nd in x ray of heart the report said the heart is minimal enlargement at time t came to know that my husband has a hole in heart by birth.he is 32 yrs old nd his heatbeat sounds so high.doctor i want to know that is he normal or neds surgery?
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My daughter is 8 and is sufferring from fever which goes upto about 38C and keeps coming back every 8 to 9 hours after we give her paracetamol , not sure if its a viral infection or some other infection like urine infection , etc, the doctor has prescribed clarithromycin as well , which she has already taken 5 times
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My baby is one nd half year she is always sick when she eats banana she has flu.nw her chest infection I gave her antibiotics syrup amoxcyline and steam everyday. She was fine previous day but yesterday again she had fever nw the dr said she has infection her ear also again he gave antibiotics tblt what should I do. .?? I give her or not She doesn t eat any thing.. Can u plz suggest something for her diet?? which I gave her .. M worried about her so mch..
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I was told by my internist that I need to stop taking Diclofenac Sodium 50mg tab because it is affecting my kidney function. My last blood test showed my kidney function was abnormal and that I now need to see a nephrologist. However, when I looked at the Consumer Medical information enclosed with my Diclofenac, there is no mention of this medication affecting your kidneys. Can any type of antiinflammatory medication affect your kidney function, and if so, why isn t it mentioned on the consumer medication info included with these medicines. By the way, I am taking Diclofenac for osteoarthritis. Thank you in advance, and I m hoping you can give me some answers.
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mY 7 YEAR OLD SLEPTED IN THE FLOOR BY OUR CHRISTMAS TREE. sPIDERS CAME OUT OF THE BOX FROM THE BASEMENT. TRIED TO KILL THEM ALL . HE MOSTLY GOT BIT ON HIS FEET DIDNT GET BIT AGAIN FOR 2 NIGHTS ..SLEPT IN BED OF CORSE THEN THIS MORNING BITES ALL OVER AGAIN. i HAVE TORE THE ROOM APART SEARCHED MATTRES EDGES VACCUMED ..nO SIGN OF BED BUGS. FOUND A VERY HARD SHELLED BEETLE BUT LARGER AND DIFFERENT DESIGNED THAN ALL THE BED BUGS PICTURED ON INTERNET. wORRIED CLEANING LIKE A MAD WOMEN. MOSTLY WORRIED ABOUT ALL THOSE BITE. nO BROKEN SKIN.. NO SIGNS OF INFECTION.
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I have found a hard lump at the bottom of my tailbone which is very painful especially when I sit down. I had it for a few months. I went to the doctors and took antibiotics which haven t worked. 5 weeks later and its still there. is it anything dangerous.
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Hello doctor, Recently my thyroid went up and since then, I have been feeling a gushing and thumping feeling in my chest that only happens at night. The feeling is in my upper chest. It lasts for two hours off and on. The doctor put me on Metoprolol tartrate 25 mg. He told me to cut the pill in half. Then take one half of the pill after my meal in the morning and after dinner. But I still have this same feeling. So the doctor put a halter monitor on me and told me to take half the pill after breakfast and one whole pill after dinner to see if the thumping feeling slows down. The doctor also told me it was the left ventricle and interventricular artery not meeting which is why this is occurring. What else can I do I can not take this feeling it is very distracting, and I want to know if there is anything else that can help? I also have elevated lymph nodes in the armpit near my left breast. I have attached the documents and medication list.
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