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can stress cause adult acne breakout
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Researchers believe that stress hormones can worsen acne. Certain steroid hormones, like glucocorticoids and adrenal androgens, are released during stress, and are known to cause breakouts by activating the oil gland and clogging your pores, according to researchers at the Stanford University.
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Researchers believe that stress hormones can worsen acne. Certain steroid hormones, like glucocorticoids and adrenal androgens, are released during stress, and are known to cause breakouts by activating the oil gland and clogging your pores, according to researchers at the Stanford University.
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eng_Latn
| 32,000 |
population prevalence for acne
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Nearly 17 million people in the United States have acne, making it the most common skin disease. (Source: excerpt from Questions and Answers About Acne: NIAMS) More Statistics about Acne: Hospitalization statistics; All statistics for Acne About prevalence and incidence statistics: The term 'prevalence' of Acne usually refers to the estimated population of people who are managing Acne at any given time. The term 'incidence' of Acne refers to the annual diagnosis rate, or the number of new cases of Acne diagnosed each year.
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10 Most Common Causes of Acne. Acne is a very annoying part of life for most people. It effects over 17 million people across the globe; often during their teenage years, but also well after that for many adults. Most assume acne only develops for those between the ages of 12-20, but such is not the case.
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eng_Latn
| 32,001 |
has accutane ever not worked
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Accutane did not work for me. I was on it for eight months hoping it would clear my face but it didn't. It works for a large majority of people but i guess i was a rarity. dried the hell out of my skin and i had all those other symptoms that everyone has heard about.
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I've been on Accutane for about 2 1/2 months, and I have seen no improvement. My body acne had begun to clear up slightly, but now I am getting painful whiteheads on my chest and back. My face had peeled off, leaving pink flesh exposed. It was wet with pus and just plain painful.
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eng_Latn
| 32,002 |
what cosmetic procedures can get rid of large pores on nose?
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Oiler skin tends to have larger, more noticeable pores. The larger the oil production, the larger the pore, and vice versa, Chasin says. Some areas of your face may be oilier and show more visible pores than others. If the pores on your nose, cheeks, or forehead are large, try spot treating with a clay mask. Smooth a thin layer on clean skin, leave it on for several minutes, and rinse it off with water. The clay can quickly and gently wick extra oil out of congested pores so that your skin appears smoother.
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Rhinoplasty â Nose Reshaping. A Rhinoplasty, or nose reshaping procedure is a very popular cosmetic surgery procedure amongst both men and women. A lot of people can be self-conscious about a particular aspect of their appearance and many people are unhappy with the shape of their nose.
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eng_Latn
| 32,003 |
what does coconut oil do for your acne
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Some believe that coconut oil is a miracle cure for acne. While coconut oil does have some acne-fighting qualities that will help your skin, the truth is that there are better options easily available.
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It is also well-known for its capacity to cure pimples. Coconut oil is believed to have powerful regenerating, antibacterial and anti-inflammatory action. Many people already use coconut oil on daily basis. They are convinced that organic coconut oil is good for pimples. Some people say that the oil can provoke acne.
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eng_Latn
| 32,004 |
hi i hav had a pimple for like 2 weeks and it finally is scabbing and i got a date tommorow and i mean its not the end of the world but what can i do for this scab to be gone by tommorow, i kind of picked it off already lol but would neosporin and alcohol swabbing it work. And then sleeping with a bandaid on it
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messing around with it is the worst thing you can do. It'll prolong the life of it so in fact you're doing the pimple and scab a favor.\n\nRule number 1. Do not mess around with your pimples or scabs\nRule number 2. If you disagree with rule number 1 then read rule 3\nRule number 3. Obey rule 1
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In the fridge, a turkey will defrost at about 5 pounds per day. If you put it in tonight, it will be defrosted by about Tuesday. That's pretty near to perfect, because it can easily last defrosted until Thursday.\n\nBe sure to put a plate or something underneath the turkey, because you may get some leakage as the ice melts.\n\nGood luck!!
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eng_Latn
| 32,005 |
Is it normal to get pimples under your armpits?
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Is it normal to have pimples on armpits and groin?
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How do I get rid of pimples on my armits?
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eng_Latn
| 32,006 |
home remedies for acne cyst
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Unlike other forms of Acne like Blackheads and Whiteheads, Acne Cysts are also accompanied by symptoms like pain, tenderness and inflammation. Though less common, still Cystic Acne may also develop on shoulders, arms, legs, back and trunk. ⢠Rinsing the face with a solution of apple cider vinegar and water mixed in equal parts is one of the best home remedies for Cystic Acne treatment. Apple cider vinegar can also be used in combination with green tea.
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Unlike other forms of Acne like Blackheads and Whiteheads, Acne Cysts are also accompanied by symptoms like pain, tenderness and inflammation. Though less common, still Cystic Acne may also develop on shoulders, arms, legs, back and trunk. ⢠Rinsing the face with a solution of apple cider vinegar and water mixed in equal parts is one of the best home remedies for Cystic Acne treatment. Apple cider vinegar can also be used in combination with green tea.
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eng_Latn
| 32,007 |
The chemistry of the natural order cupressales—XXI : Cuparene and cuparenic acid, two sesquiterpenic compounds with a new carbon skeleton
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Organic residue analysis of Egyptian votive mummies and their research potential
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Exposure to toluene in the printing industry is associated with subfecundity in women but not in men
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eng_Latn
| 32,008 |
On the emergence of TER as an existential verb in Brazilian Portuguese
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Distributed morphology and the pieces of inflection
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Endogenous Uremic Substances are not Involved in the Reduced Hepatic Extraction of Metoprolol in Bilateral Ureter-Ligated Rats†
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eng_Latn
| 32,009 |
Migraine has been associated with patent foramen ovale (PFO), and PFO closure has become the most high-profile nonpharmacologic invasive therapy recommended for the prevention of recurrent migraine attacks, as well as for preventing further attacks in cryptogenic stroke. The results of Migraine Intervention with STARFlex Technology (MIST), a controversial but important recent randomized clinical trial (RCT) of PFO closure for migraine, do not support PFO closure for preventing migraine attacks. All patients with migraine, however, do not have a PFO, and the characteristic periodicity and predictability of migraine cannot be explained on the basis of paradoxical embolism through the PFO. Closure of the PFO or atrial septal defect can aggravate migraine suddenly. PFO increases in size with age, but migraine generally subsides with the passage of years. Serendipity does play a role in some medical discoveries, but in the absence of a logically defensible theoretical basis, chance and statistics can both become misleading. With soft end points, RCTs in migraine patients can generate conflicting and irreconcilable data. RCTs cannot supplant or substitute clinical common sense or justify serendipity. Scientific progress mandates that any serendipitous research must ultimately conform to the principles of the basic sciences surrounding the chance discovery. PFO closure for preventing migraine attacks is an unfortunate, but sobering, chapter in the migraine research saga.
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Patent foramen ovale and atrial septal aneurysm are considered to be factors conducive to the occurrence of stroke and transient ischaemic attacks. However, there is no clear answer to the question whether patent foramen ovale is an independent risk factor for stroke and what the mechanism of potential cerebral ischaemia in patients with an interatrial septal abnormality is. The paper presents the results of studies regarding the issue, including epidemiological, clinical and neuroimaging data. The subject of secondary prevention in patients with cryptogenic stroke and patent foramen ovale, including the results of research into the effectiveness of pharmacological methods and percutaneous closure of interatrial septal defects, is raised. The available research results do not conclusively suggest a causal relationship between patent foramen ovale and stroke. There is a probable summative effect of atrial septal abnormality and other factors (haemostatic and genetic ones as well as those that are associated with cerebral vessels) leading to cerebral ischaemia. There are no indications for the use of anticoagulant treatment in patients with stroke and presence of patent foramen ovale. In patients at a high risk for stroke, invasive treatment should be considered, which is consistent with the position of the European Stroke Organisation.
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Structural characterization of pyrolysis fuel oil (PFO) was conducted via 1H NMR and 13C NMR to elucidate its molecular structure and evaluate the feasibility of using PFO as a raw material for mesophase pitch synthesis. The average structural parameters were calculated based on the data from elemental analysis and matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS), as well as 1H NMR and 13C NMR data. The resultant structural features of PFO were compared with those of fluidized catalytic cracking-decant oil (FCC-DO). Based on the calculated parameters, we proposed average molecular models of PFO and FCC-DO. The molecular model of PFO showed that it had an aromatic structure consisting of three aromatic rings and one naphthenic ring fused with one pericondensed and two catacondensed aromatic carbons, as well as a short alkyl side chain (with only a methyl group). This structural feature of PFO demonstrated that it is highly favorable for use as a raw material for mesophase pitch synthesis. The empirical findings in this study provide an in-depth understanding of the molecular structure of PFO as well as FCC-DO and can offer insights for future research on the utilization of PFO and other petroleum heavy oils.
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eng_Latn
| 32,010 |
Far-infrared moxibustion plaster
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The utility model relates to the technical field of medical devices, and specifically relates to a far-infrared moxibustion plaster. The far-infrared moxibustion plaster comprises a far-infrared moxibustion plaster body, the far-infrared moxibustion plaster body comprises a bottom layer, two ends of the bottom layer are respectively and correspondingly provided with a ventilating paste layer, the bottom layer is provided with a tourmaline far-infrared mineral heating layer, a herb moxibustion therapy layer and a physiotherapy liquid introduction layer in sequence from the inside to the outside, and the surface of the herb moxibustion therapy layer is provided with a moxibustion physiotherapy liquid layer. The far-infrared moxibustion plaster is advantaged by simple structure, reasonable arrangement, low manufacturing cost, energy saving, and environmental protection, the operation of the moxibustion is simple, and the carrying of the far-infrared moxibustion plaster is convenient, easy and free.
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e15031Background: FOLFOXIRI and bev achieve high response rate/R0 resections and encouraging PFS in patients with unresectable CLM. Pathological response, a surrogate endpoint of survival, is incre...
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eng_Latn
| 32,011 |
Study on the Industryial Production of Citalopram
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Citalopram was an effective and safe antidepressant which existed in the market for many years and had great market value.To realize the industrial production of citalopram,the process was improved based on the patent US4943590.The improved process was 4-(4-(dimethylamino)-1-(4-fluorophenyl)-hydroxy-butyl)-3-(hydroxymetheyl)-benzonitrile was dissolved in toluene at 0 ℃.Toluene sulfochloride was used as acylation reagent,HCl generated in the acylation reaction was absorbed by Na2CO3 water solution(20 wt-%).The conversion rate of the process was higher than 99%,and the purity of the product was more than 99.5%.This improved process was very easy to carry out,those chemical materials were commercialized and cheep,and low pollutant discharge,which can satisty the need of industrialized production.
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This article reports the results of a survey of a representative sample of the membership of the Christian Association for Psychological Studies International to discover the books and audio-visual...
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eng_Latn
| 32,012 |
Evaluation Synthesis.
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Synthesis of the evaluation.
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Evaluation dissolution.
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yue_Hant
| 32,013 |
Synthesis of (2R,3R,4S)-2-hydroxymethylpyrrolidine-3,4-diol from (2S)-3,4-dehydroproline derivatives.
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Convenient Synthesis of 1,4-Dideoxy-1,4-imino-D-ribitol from D-Ribose
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Opposite sexual dimorphism of 3,4-dihydroxyphenylalanine decarboxylase in the kidney and small intestine of mice
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eng_Latn
| 32,014 |
Development of a liquid-liquid extraction procedure for five 1,4-dihydropyridines calcium channel antagonists from human plasma using experimental design.
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Validation of methodology for assay, pharmaceutical equivalence, and comparative dissolution profile for tablets containing amlodipine besylate
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A straightforward route to enantiopure 2-substituted-3,4-dehydro-β-proline via ring closing metathesis
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eng_Latn
| 32,015 |
Supercritical fluid extraction followed by nanostructured supramolecular solvent extraction for extraction of levonorgestrel and megestrol from whole blood samples
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Dispersed Solidified Fine Droplets Based on Sonication of a Low Melting Point Deep Eutectic Solvent: a Novel Concept for Fast and Efficient Determination of Cr(VI) in Urine Samples
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A compact VEGF signature associated with distant metastases and poor outcomes
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eng_Latn
| 32,016 |
Stability of famotidine in an extemporaneously prepared oral liquid.
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Stability considerations in liquid dosage forms extemporaneously prepared from commercially available products.
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Stability considerations in liquid dosage forms extemporaneously prepared from commercially available products.
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eng_Latn
| 32,017 |
Aqueous-based cellulose acetate butyrate dispersion: Screening of process and formulation variables to obtain verapamil HCl-controlled release beads
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Effect of Eudragit® RS 30D and Talc Powder on Verapamil Hydrochloride Release from Beads Coated with Drug Layered Matrices
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Venous thromboembolism rates in patients with lower limb immobilization after Achilles tendon injury are unchanged after the introduction of prophylactic aspirin: audit
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eng_Latn
| 32,018 |
Availability indicates that a system continuously provides a useful service at any given time. With the success of Internet-based business, there is more and more interest in the availability of systems. This paper presents the Availability Management Framework(AMF), which supports the management of availability for applications in layered distributed systems. We focus on the AMF's flexibility in order to support various failure detection and recovery mechanisms that are required by each application. In addition, this paper describes the result of application of the AMF to support availability of RFID systems.
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The invention relates to the enzyme S-tetrahydroprotoberberineoxidase, which oxidizes selectively S-tetrahydroprotoberberines and S-1-benzyl-1,2,3,4-tetrahydroisoquinoline in the presence of oxygen, resulting in the corresponding protoberberines and 1-benzyl-3,4-dihydroisoquinolines. The invention also relates to a process of preparing S-tetrahydroprotoberberineoxidase by extraction from certain plant materials. The oxidation products of several compounds find use in the pharmaceutical industries.
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Berzelius failed to make use of Faraday's electrochemical laws in his laborious determination of equivalent weights.
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eng_Latn
| 32,019 |
A method for the direct analysis of drug compounds in plasma using a single restricted access material (RAM) column.
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The use of a temperature-responsive column for the direct analysis of drugs in serum by two-dimensional heart-cutting liquid chromatography
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Delayed Reactive Distractor Suppression in Aging Populations
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eng_Latn
| 32,020 |
The potentials of XAD-columns for the isolation of quaternary ammonium compounds from aqueous media have been investigated. When adequate amounts of counter ions (perchlorate, chloride, phosphate, nitrate) were added to the aqueous sample, to the column pretreatment fluid and to the aqueous washing fluid, most quaternary compounds investigated were retained on the column and could be recovered by elution with methanol. This approach proved also suitable for urine. Quantitation of quaternaries isolated in this way from urine samples could be performed on silicagel thin layer plates through visualization with iodine, followed by densitometric evaluation. For decamethonium detection limits were 0.1 μg/ml. Recoveries at the 1 μg/ml level were between 80–90% with variation coefficients of less than 10%.
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We describe a procedure for extracting weakly acidic, neutral, and basic drugs from urine by using a column of XAD-2 resin. Adsorption of drugs from 20 ml of urine buffered at pH 8.5 ± 0.5 at a controlled flow rate of 2.5 ml/min was greater than 89% for all drugs tested except aspirin. On eluting the drugs tested with acetone and methanol/chloroform, recoveries ranged from 75 to 93%. Overall recoveries of drugs from urine to a thin-layer chromatography plate were between 63 and 78%. The concentration of morphine added to normal urine that can be detected 99% of the time (95% confidence limits) by this method was 80 (65-100) µg/liter. We evaluated three methods for recovering morphine from morphine glucuronide added to urine, by using appropriate modifications of the XAD-2 resin extraction method. Hydrolysis of urine, hydrolysis of urine extracts adsorbed on XAD-2 resin, and hydrolysis of urine extracts from the XAD-2 resin followed by a solvent extraction gave 75%, 40%, and 10% recoveries of morphine, respectively.
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We prove that groups acting geometrically on delta-quasiconvex spaces contain no essential Baumslag-Solitar quotients as subgroups. This implies that they are translation discrete, meaning that the translation numbers of their nontorsion elements are bounded away from zero.
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eng_Latn
| 32,021 |
Purpose: A study was made of the effects of some bases and adjuvants on the physical and release properties of metronidazole suppositories with a view to providing more information for the optimization of the rectal formulation of metronidazole. Method: Suppositories (1g) containing 200mg of metronidazole each were prepared in witepsol (H15 and E75) and polyethylene glycol (PEG 2850 and 4650) bases, using different concentrations of Tween 80, sodium salicylate and methylcellulose as adjuvants. The setting time, solidification point and melting range of the suppositories were determined, along with their crushing strength, disintegration time and the time for 80% of metronidazole to be released from the suppositories (t80). Results: The ranking of setting time for the suppositories was witepsol H15 > PEG 2850 > witepsol E75 > PEG 4650, while the ranking of solidification point, melting range, crushing strength, disintegration time and the time for 80% of metronidazole to be released from the suppositories (t80) was the reverse of that for setting time. Optimal concentrations of Tween 80 and sodium salicylate were observed for the suppository formulations. Using Kitazawa plots, all formulations showed two dissolution rate constants, k1 and k2 intersecting at time t1, with formulations containing 5 to 20 % w /w of methylcellulose exhibiting a third dissolution rate constant, k3 intersecting with k2 at time t2. Conclusion: The physical and release properties of metronidazole suppositories are influenced considerably by the bases and adjuvants employed. Tween 80 and sodium salicylate can probably be used to formulate only immediate-release suppositories while methylcellulose can be useful for sustained-release metronidazole suppositories. Some insight into these inferences can be obtained from parameters derived from Kitazawa plots.
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Double-layered matrix tablets prepared from shellac wax-lutrol were fabricated using a molding technique, and the release of hydrochlorothiazide and propranolol HCl from the inner tablet or outer layer was studied. The simultaneous determination of dual drug release was measured with first derivative UV spectrophotometry. The tablet containing shellac wax as the outer tablet and lutrol as the inner tablet showed more appropriate drug release and the size of the inner layer influenced the rate of drug release. In addition, the aqueous solubility of the drug and the components of the inner tablet or outer layer affected the drug release behavior. Most of the double-layered tablets exhibited the drug-release pattern which fitted well with zero-order kinetic due to the restriction of the release surface. Biphasic drug release pattern was found in the tablet of which the outer layer rapidly eroded. The drug dissolution data from drug-loaded-outer layer could predict the dissolution time for the outer layer of drug-loaded inner part of double-layered matrix tablet. Incorporation of lutrol increased the drug release from shellac wax matrix, and the zero-order release was attained by fabricating it into a double-layered tablet.
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We prove that groups acting geometrically on delta-quasiconvex spaces contain no essential Baumslag-Solitar quotients as subgroups. This implies that they are translation discrete, meaning that the translation numbers of their nontorsion elements are bounded away from zero.
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eng_Latn
| 32,022 |
Dry powder inhaler (DPI) formulations is one of the most useful aerosol preparations in which ::: drugs may be formulated as carrier-based interactive mixtures with micronised drug particles ::: (<5 μm) adhered onto the surface of large inert carriers (lactose powders). The addition of magnesium ::: stearate (MgSt) (1-3), was found to increase dispersion of various drugs from DPI formulations. ::: Recently, some active compounds coated with 5% (wt/wt) MgSt using the mechanofusion method ::: showed significant improvements in aerosolization behavior due to the reduction in intrinsic ::: cohesion force (4). Application of MgSt in powder formulations is not new; however, no studies ::: demonstrated the minimum threshold level for this excipient in efficient aerosolization of drug ::: powders from the interactive mixtures. Therefore, this study investigated the role of MgSt concentration ::: on the efficient dispersion of salbutamol sulphate (SS) from DPI formulations.
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A novel approach to concurrently deliver oral and inhaled drugs as a single formulation is presented. A triple therapy containing theophylline (THEO; orally delivered) with budesonide (BUD) and terbutaline (TERB; as single and co-spray-dried inhaled powders) was prepared as an ordered mix, with THEO acting as a carrier. The aerosolisation performance of THEO formulations containing BUD and TERB alone, physical mix and co-spray-dried powder was evaluated using a next-generation impactor (NGI). Physicochemical properties were investigated using electron microscopy, laser diffraction, dynamic vapour sorption and thermal analysis. NGI analysis indicated that >99 % of the THEO powder was >4.46 μm, with >90 % dissolved within 5 min. Particle size analysis showed TEB and BUD samples were of a suitable size for inhalation. Thermal and moisture analysis suggested powders to be stable at room temperature up to 70 % RH. Aerosol studies indicated a different performance of BUD and TERB depending on the mixing procedure. The co-spray-dried formulation showed the highest performance, with a fine particle fraction (≤4.46 μm) of BUD and TERB of 34.39 ± 3.56 and 33.61 ± 5.67 %, respectively. Such observations suggest that this multicomponent drug delivery system could be developed to concomitantly deliver oral and inhaled drugs, an approach that, to date, does not exist. Ultimately, this technology potentially reduces the requirement for multiple therapies and increases patient compliance.
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We prove that groups acting geometrically on delta-quasiconvex spaces contain no essential Baumslag-Solitar quotients as subgroups. This implies that they are translation discrete, meaning that the translation numbers of their nontorsion elements are bounded away from zero.
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eng_Latn
| 32,023 |
Because a eutectic mixture of lidocaine and procaine (EMLA cream) is used to treat pain in children who are undergoing venipuncture for screening clinical presurgery laboratory tests, this study was designed to investigate the influence of the time of application of EMLA cream on lidocaine transcutaneous absorption in children. The same phenomenon was also studied in rats. Local application of EMLA (right and left cubital fossae) was performed 1 hour before venipuncture in two groups of children (0.5 g/kg body weight at two sites), at 08:15 or 16.15 h; blood samples were performed 1 h later. Two groups of five rats each received 12 mg/kg lidocaine at 07:30 or 19.30 h by application to the back skin. Blood samples were collected 0.5, 1, 1.5, 2, 3, and 4 h after application. Plasma lidocaine levels were assayed according to an immunoenzymatic method (Abbott). Our data indicate that the lidocaine plasma levels were significantly different: higher in the evening for the children or in the morning for the rats. The plasma level of the local anesthetics (LA) represents an elimination route and thus may be inversely correlated to the skin amount of the LA.
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Hydroxypropyl methylcellulose (HPMC) gel drug reservoir system prepared with 70:30 v/v ethanol-water solvent system containing 6% w/w of limonene was effective in promoting the in vitro transdermal delivery of nicorandil. The objective of the present study was to fabricate and evaluate a limonene-based transdermal therapeutic system (TTS) for its ability to provide the desired steady-state plasma concentration of nicorandil in human volunteers. The in vitro permeation of nicorandil from a limonene-based HPMC gel drug reservoir was studied across excised rat skin (control), EVA2825 membrane, adhesive-coated EVA2825 membrane and adhesive-coated EVA2825 membrane-excised rat skin composite to account for their effect on the desired flux of nicorandil. The flux of nicorandil from the limonene-based HMPC drug reservoir across EVA2825 membrane decreased to 215.8 ± 9.7µg/cm2·h when compared to that obtained from control, indicating that EVA2825 was effective as a rate-controlling membrane. The further decrease in nicorandil flux across adhesive-coated EVA2825 membrane and adhesive-coated EVA2825 membrane-excised rat skin composite showed that the adhesive coat and skin also controlled the in vitro transdermal delivery. The limonene-based drug reservoir was sandwiched between adhesive-coated EVA2825-release liner composite and a backing membrane. The resultant sandwich was heat-sealed as circle-shaped patch (20 cm2), trimmed and subjected to in vivo evaluation in human volunteers against immediate-release tablets of nicorandil (reference formulation). The fabricated limonene-based TTS of nicorandil provided a steady-state plasma concentration of 21.3 ng/ml up to 24 h in healthy human volunteers. It was concluded that the limonene-based TTS of nicorandil provided the desired plasma concentration of the drug for the predetermined period of time with minimal fluctuations and improved bioavailability.
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The explosion of web as an information source recently has brought more interesting challenges to document annotation and classification of web documents as well as to the information and collaboration filtering world. Not only does it introduce performance issues due to the huge number of documents, there is even bigger challenges in that most of the data are unlabeled. The arrival of social media and blogging has increased web data as well. Thus the machine learning community has taken up the interest in using unsupervised learning in classification of such big data. New learning called semi-supervised learning relies on assumptions that unlabeled data can help bring interesting patterns, which the industry can use. The study uses the Probability Latent Semantic Analysis algorithm which is an unsupervised machine learning algorithm to retrieve information based on latent classes of documents and terms. PLSA is the topic modeling tool used by the study to deduce hidden topics across the documents by looking at the terms and documents and inferring using the Expectation Maximization algorithm which words belong to which topic. The model was used to discover if given documents infer one or more topics. The study concluded that the PLSA algorithm is more efficient on processed data than raw web data and processing time was reduced when preprocessing was used to eliminate redundant latent variables. An increase of k, the number of topics improved the topic quality.
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eng_Latn
| 32,024 |
To every morphism χ : L → M of differential graded Lie algebras we associate a functors of artin rings Defχ whose tangent and obstruction spaces are respectively the first and second cohomology group of the suspension of the mapping cone of χ . Such construction applies to Hilbert and Brill-Noether functors and allow to prove with ease that every higher obstruction to deforming a smooth submanifold of a Kahler manifold is annihilated by the semiregularity map. Mathematics Subject Classification (2000): 13D10 (primary); 14D15 (secondary).
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We analyse infinitesimal deformations of pairs $(X,\mathcal{F})$ with $\mathcal{F}$ a coherent sheaf on a smooth projective manifold $X$ over an algebraic closed field of characteristic $0$. We describe a differential graded Lie algebra controlling the deformation problem, and we prove an analog of a Mukai-Artamkin Theorem about the trace map.
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A recently developed preparative technique, pH-zone-refining countercurrent chromatography (CCC), separates organic acids and bases according to their pKa and hydrophobicity. The hydrodynamic mechanism of pH-zone-refining CCC is illustrated in two elution modes along with a simple mathematical analysis. Separations include acidic and basic derivatives of amino acids and peptides, hydroxyxanthene dyes, alkaloids, indole auxins, and structural and geometrical isomers. In addition, recently developed affinity ligand separations of enantiomers, polar catecholamines, and free peptides are also described. Technical guidance is provided for interested users so that they can conduct a systematic search for the optimum solvent system and experimental conditions. Advantages as well as limitations of the present technique are discussed.
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eng_Latn
| 32,025 |
The potential for using tyrosinase to graft the polysaccharide chitosan (Ch) onto Bombyx mori silk fibroin (SF) was examined. FT-IR spectroscopy coupled to HPLC amino acid analysis showed that mushroom tyrosinase (MT) catalyses the oxidation of tyrosine (Tyr) of SF to electrophilic o-quinones. Kinetic studies showed that only a fraction of the Tyr residues available on the SF chain were oxidized. This result was interpreted in the light of the structure assumed by SF in aqueous solution: Tyr aromatic side chain groups buried into the folded hydrophobic portions of the chain were probably less accessible to MT for steric reasons. Using slightly acidic conditions (pH 6), it was possible to modify SF under homogeneous conditions. FT-IR spectroscopy provided evidence that Ch was grafted onto MT-oxidized SF: the o-quinones were found to undergo a subsequent non-enzymatic reaction with nucleophilic amino groups of Ch via Schiff-base and Michael addition mechanisms. Various factors, i.e. reaction time, pH, MT/SF ratio, were found to influence the grafting yield. The highest grafting yield was achieved at pH 7, i.e. more favorable to MT activity rather than to Ch solubility, suggesting that the determining step of the grafting reaction is the formation of o-quinones. The FT-IR spectroscopy revealed that grafting induced a beta-sheet --> random coil conformational transition.
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Polymers are extensively used in the pharmaceutical and medical field because of their unique and phenomenal properties that they display. They are capable of demonstrating drug delivery properties that are smart and novel, such properties that are not achievable by employing the conventional excipients. Appropriately, polymeric refabrication remains at the forefront of process technology development in an endeavor to produce more useful pharmaceutical and medical products because of the multitudes of smart properties that can be attained through the alteration of polymers. Small alterations to a polymer by either addition, subtraction, self-reaction, or cross reaction with other entities have the capability of generating polymers with properties that are at the level to enable the creation of novel pharmaceutical and medical products. Properties such as stimuli-responsiveness, site targeting, and chronotherapeutics are no longer figures of imaginations but have become a reality through utilizing processes of polymer refabrication. This article has sought to review the different techniques that have been employed in polymeric refabrication to produce superior products in the pharmaceutical and medical disciplines. Techniques such as grafting, blending, interpenetrating polymers networks, and synthesis of polymer complexes will be viewed from a pharmaceutical and medical perspective along with their synthetic process required to attain these products. In addition to this, each process will be evaluated according to its salient features, impeding features, and the role they play in improving current medical devices and procedures.
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The oxidative polymorphism of debrisoquine (DBQ) has been determined in 89 patients with colo-rectal cancer and in 556 normal control subjects. Four patients and 34 controls, with a metabolic ratio >12.6, were classified as poor metabolisers of DBQ (n.s.).
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eng_Latn
| 32,026 |
Neurodegenerative diseases, referring to as the progressive loss of structure and function of neurons, constitute one of the major challenges of modern medicine. Traditional Chinese herbs have been used as a major preventive and therapeutic strategy against disease for thousands years. The numerous species of medicinal herbs and Traditional Chinese Medicine (TCM) compound formulas in nervous system disease therapy make it a large chemical resource library for drug discovery. In this work, we collected 7362 kinds of herbs and 58,147 Traditional Chinese medicinal compounds (Tcmcs). The predicted active compounds in herbs have good oral bioavailability and central nervous system (CNS) permeability. The molecular docking and network analysis were employed to analyze the effects of herbs on neurodegenerative diseases. In order to evaluate the predicted efficacy of herbs, automated text mining was utilized to exhaustively search in PubMed by some related keywords. After that, receiver operator characteristic (ROC) curves was used to estimate the accuracy of predictions. Our study suggested that most herbs were distributed in family of Asteraceae, Fabaceae, Lamiaceae and Apocynaceae. The predictive model yielded good sensitivity and specificity with the AUC values above 0.800. At last, 504 kinds of herbs were obtained by using the optimal cutoff values in ROC curves. These 504 herbs would be the most potential herb resources for neurodegenerative diseases treatment. This study would give us an opportunity to use these herbs as a chemical resource library for drug discovery of anti-neurodegenerative disease.
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BACKGROUND ::: Neurodegenerative disorders (NDs) are diverse group of disorders characterized by escalating loss of neurons (structural and functional). The development of potential therapeutics for NDs presents an important challenge, as traditional treatments are inefficient and usually are unable to stop or retard the process of neurodegeneration. Computer-Aided Drug Design (CADD) has emerged as an efficient means of developing candidate drugs for the treatment of many disease types. Applications of CADD approach to drug discovery are progressing day by day. The recent tendency in drug design is to rationally design potent therapeutics with multi-targeting effects, higher efficacies, and fewer side effects, especially in terms of toxicity. ::: ::: ::: METHODS ::: A wide literature search was performed for writing this review. An updated view on different types of NDs, their effect on human population and a brief introduction to CADD, various approaches involved in this technique, ranging from structural-based to ligand-based drug design has been discussed. The successful application of CADD approaches for the treatment of neurodegenerative disorders is also included in this review. ::: ::: ::: RESULTS ::: In this review, we have briefly described about CADD and its use in the development of the therapeutic drug candidates against NDs. The successful applications, limitations and future prospects of this approach have also been discussed. ::: ::: ::: CONCLUSION ::: CADD can assist researchers studying interactions between drugs and receptors. We believe this review will be helpful for better understanding of CADD and its applications towards the discovery of new drug candidates against various fatal NDs.
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Berzelius failed to make use of Faraday's electrochemical laws in his laborious determination of equivalent weights.
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eng_Latn
| 32,027 |
Chronic HBV infection is a common cause of advanced liver disease that is associated with substantial mortality. Furthermore, chronic hepatitis B was historically a controversial indication for liver transplantation because of a low post-transplant survival, with graft infection being the major contributor to adverse outcomes. The initial use of hepatitis B immune globulin as prophylaxis, followed later by combined therapy with lamivudine, markedly reduced viral recurrence and improved the survival of patients transplanted for acute or chronic hepatitis B with liver failure. Lamivudine alone can also be used for long-term prophylaxis against de novo HBV infection that can be transmitted by organs from donors positive for anti-HBc or anti-HBs. When used in patients with decompensated chronic hepatitis B with cirrhosis, lamivudine has been shown to improve clinical manifestations, prolong pretransplant survival, and defer, or even obviate, the need for transplantation. Despite prophylaxis, viral mutations with breakthrough reinfection may occur and lead to liver failure. The recently approved adefovir dipivoxil, which is active against lamivudine-resistant mutation, and other nucleoside analogs that are in various phases of development, offer hope as rescue therapy for viral recurrence. Other therapeutic alternatives in the future may include gene therapy and immune interventions.
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Methods and compositions are provided for cleaning and inhibiting the formation of fouling deposits on jet engine components during the combustion of turbine combustion fuel oils. Methods and compositions are also provided for inhibiting the formation and emission of soot and smoke from jet engine exhaust during turbine combustion fuel oil combustion. The methods employ a derivative of (thio)phosphonic acid added to the turbine combustion fuel oil. The preferred derivative is pentaerythritol ester of polyisobutenylthiophosphonic acid.
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Berzelius failed to make use of Faraday's electrochemical laws in his laborious determination of equivalent weights.
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eng_Latn
| 32,028 |
OBJECTIVE To establish a method for the assay of Rifaximin and its related substances.METHODS An RP-HPLC method was used with C 18 column(5 μm,150 mm×4.6 mm). The mobile phase was a mixture of methanol-acetonitrile-0.05 mol·L -1 monopotassium phosphate-0.5 mol·L -1 citric acid(50∶25∶20∶5).The detect wavelength was set at 254 nm.RESULTS The linear range of Rifaximin was 50-200 μg·ml -1 (r=0.9999).The average recovery was 99.9%. CONCLUSION This method is simple, selective and reproducible for the assay of Rifaximin and its related substances.
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Rifaximin, an oral antimicrobial, has many advantages because it is selective intestine, has minimal adverse effects and is used for the treatment of some diseases such as hepatic encephalopathy, irritable bowel syndrome, travelers' diarrhea, ulcerative colitis, Clostridium difficile and acute diarrhea. Rifaximin in the form of 200 mg tablets is commercially available. The crystalline α form is therapeutically safe and effective. In most of the official compendia, rifaximin has no monograph and in none of them is there a monograph for rifaximin tablets. The literature, however, contemplates this gap with varied methods. The literature presents some methods for evaluation of rifaximin in both biological fluid and pharmaceutical product. High performance liquid chromatography stands out for the evaluation of rifaximin. Most of the methods reported in the literature are for pharmaceuticals products. They use (1) toxic organic solvents, harmful to the operator and the environment, and/or (2) buffer solution, which has a shorter service life and requires time-consuming washes of the chromatographic system generating more waste. So, this work aims to discuss (i) properties; (ii) applications; (iii) polymorphism and (iv) analytical methods of rifaximin by the look of green chemistry. This review shows an extremely current topic of great importance to the chemical-pharmaceutical area and everything it involves, since the analytical process until the impact on the environment in which it is embedded.
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Rifaximin, an oral antimicrobial, has many advantages because it is selective intestine, has minimal adverse effects and is used for the treatment of some diseases such as hepatic encephalopathy, irritable bowel syndrome, travelers' diarrhea, ulcerative colitis, Clostridium difficile and acute diarrhea. Rifaximin in the form of 200 mg tablets is commercially available. The crystalline α form is therapeutically safe and effective. In most of the official compendia, rifaximin has no monograph and in none of them is there a monograph for rifaximin tablets. The literature, however, contemplates this gap with varied methods. The literature presents some methods for evaluation of rifaximin in both biological fluid and pharmaceutical product. High performance liquid chromatography stands out for the evaluation of rifaximin. Most of the methods reported in the literature are for pharmaceuticals products. They use (1) toxic organic solvents, harmful to the operator and the environment, and/or (2) buffer solution, which has a shorter service life and requires time-consuming washes of the chromatographic system generating more waste. So, this work aims to discuss (i) properties; (ii) applications; (iii) polymorphism and (iv) analytical methods of rifaximin by the look of green chemistry. This review shows an extremely current topic of great importance to the chemical-pharmaceutical area and everything it involves, since the analytical process until the impact on the environment in which it is embedded.
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eng_Latn
| 32,029 |
Frankincense hunt threatens leopards
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The habitat of one of the world's rarest and most elusive big cats is shrinking fast, with the latest pressure coming from frankincense collectors. Only around 200 critically endangered Arabian leopards remain in the wild, mainly in Oman. A small but thriving population there is now being squeezed out by humans, camera trap photos suggest. They have seen leopards moving away from areas where they used to be, says Hadi Al Hikmani, a wildlife biologist at the Office for Conservation of the Environment in Oman.
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OBJECTIVE To study the effect of solvents on the permeation of leflunomide in excised mouse skin. METHODS Modified Franz-diffusion cell adopted as apparatus for in vitro skin permeation, excised mouse skin as permeation barrier and permeability as index, the concentration of leflunomide in the samples was measured by HPLC. RESULTS Ethanol has enhancement effect on the permeability of leflunomide, propylene glycol and lower concentration DMI have little effect on the permeability of leflunomide. CONCLUSIONS These solvents can be used in the skin local preparations of leflunomide.
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vie_Latn
| 32,030 |
Purified protein derivative tuberculin and delayed-type hypersensitivity skin testing in migrant farm workers at risk for tuberculosis and HIV coinfection
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Objective: To assess the joint use of purified protein derivative (PPD) and delayed-type hypersensitivity (DTH) antigens in screening individuals of unknown HIV serostatus for tuberculosis (TB) preventive therapy eligibility. Design: Population-based survey. Methods: A group of migrant farm workers were screened for HIV and skin-tested with PPD, tetanus toxoid (TET), Candida albicans (CAN) and mumps (MUM) antigens by the Mantoux method. Anergy was defined as a ≤2 mm reaction to all four antigens. Eligibility for preventive therapy was defined as a reaction of ≥5 mm to PPD among HIV-seropositive individuals, ≥10 mm among HIV-seronegatives, or anergy. Results: A total of 253 out of 271 individuals had sufficient data for analysis
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Objective To study the best extracting technology of Compound Taizishen Granule prescription.Methods The total polysaccharides and total saponins were determined by UV spectrophotometer.With the content of total polysaccharides and total saponins as comprehensive indexes,orthogonal test was applied to investigation of the water addition,extraction time,and extraction times for optimizing the best extracting technology.Results The best extracting technology was using 10 times the amount of water,extracting 3 times and 1.5 h per time.Conclusion The extraction technology is safe and effective,which can be used as extraction for Compound Taizishen Granule prescription.
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eng_Latn
| 32,031 |
New aryl- () -propyl-amides, their preparation process and pharmaceutical compositions containing them.
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The invention relates to compounds of formula (I) wherein A, R SUB {1}, {R SUB, 2}, {R SUB, 3} n are as defined in the description. MEDICINES.
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*† ‡ § A multi-phase model for the combustion of ammonium dinitramide (ADN) monopropellant is presented. As part of the work, an in depth study concerning ADN combustion has been undertaken. An extensive literature review has been conducted to extract both experimental data and qualitative theories concerning ADN combustion. Analyses and reviews are presented pertaining to some of the major theories. Based on the literature review a numerical model has also been developed for ADN using the BYU PHASE3 combustion code. The model accurately predicts burning rates, temperature and species profiles, and other combustion characteristics of ADN at pressures preceding the unstable region (20 to 100 atm) of combustion. Burning rates are also predicted in the unstable zone and at higher pressures. Results are discussed and proposed modifications to the present condensed phase model are presented. Nomenclature b = constant in burning rate correlation P = pressure n = pressure exponent
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eng_Latn
| 32,032 |
The Progress and Future Prospects of Cycloaddition to [ 60]Fullerene
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Researches on[2+1]cycloaddition, [2+2]cycloaddition, [2+3]cycloaddition and [2+4]cycloaddition to [60]fullerene are reviewed. The Study foreground and the development direction of [60]fullerene are discussed.
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This article summarized the accomplishment and the brief history of research and development on new TCMs along to the evolution of drug register regulations in China,and focused on analyzing of those new TCMs in market and comparison with the Western drugs launched marked in the period,which in order to release the shortage of new TCMs.Strategies and methodology of future innovation of TCMs should pay more attention to their clinical efficacy.
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eng_Latn
| 32,033 |
Advanced composite thermoplastics
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Abstract A description of the properties, processing and applications of a recently developed thermoplastic resin system is given.
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Objective To study the best extracting technology of Compound Taizishen Granule prescription.Methods The total polysaccharides and total saponins were determined by UV spectrophotometer.With the content of total polysaccharides and total saponins as comprehensive indexes,orthogonal test was applied to investigation of the water addition,extraction time,and extraction times for optimizing the best extracting technology.Results The best extracting technology was using 10 times the amount of water,extracting 3 times and 1.5 h per time.Conclusion The extraction technology is safe and effective,which can be used as extraction for Compound Taizishen Granule prescription.
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eng_Latn
| 32,034 |
Release of multi-components in GardeniaTotal Glycosides Sustained-release Tablets in vitro
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Objective To explore the evaluation method for in vitro release of multi component in Gardenia Total Glycosides Sustained-release Tablets. Methods Rotating basket method was carried out to determine the release rate. HPLC method was employed to assess the release rate of gardenoside, genipingeniobioside, and geniposide, and UV method was used to determine the total glycosides. Results The release rates of gardenoside, genipingeniobioside, geniposide, and total glycosides were similar. Similarity factors were 81%, 72%, and 91%. The data of cumulative release rate fitted best with Higuchi model. The release of Gardenia Total Glycosides Sustained-release Tablets had a well-balanced release behavior. Conclusion Quality of multi-components in Gardenia Total Glycosides Sustained-release Tablets can be controlled effectively by the method.
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Objective To study the best extracting technology of Compound Taizishen Granule prescription.Methods The total polysaccharides and total saponins were determined by UV spectrophotometer.With the content of total polysaccharides and total saponins as comprehensive indexes,orthogonal test was applied to investigation of the water addition,extraction time,and extraction times for optimizing the best extracting technology.Results The best extracting technology was using 10 times the amount of water,extracting 3 times and 1.5 h per time.Conclusion The extraction technology is safe and effective,which can be used as extraction for Compound Taizishen Granule prescription.
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eng_Latn
| 32,035 |
Use of a strain of Lactobacillus for the manufacture of a medicament for reduction of the fibrinogen level in blood
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The invention refers to the use of a strain of Lactobacillus for the manufacture of a medicament for reduction of the fibrinogen level, and optionally cholesterol level, in blood. Said medicament can be utilized for the prophylaxis and/or treatment of circulatory diseases.
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The present invention provides fiber having persistence uvioresistant mold resistance, belonging to weaving and application area.It contains cotton, ramie, flax, Jute, gambo hemp, cannabis Sativa, Apocynum venetum, hair, tussah silk, mulberry silk, textile fibre, weaving products and methyloic chemical fiber like substance. Said method contains to make fiber carboxy methylation reaction to generate carboxymethyl cellulose, after through carboxymethyl cellulose with butyl titanate hydrolytic reaction to generate chemical bonding nano titanium oxide - carboxymethyl cellulose. Said invention has strong uvioresistant antibiosis ability, lasting action, solving easy desorption shortage of traditional method.
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eng_Latn
| 32,036 |
Allene inhibitor agent to catalyst of a metal of the platinum group and the organopolysiloxane compositions containing
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RESPECT THE INVENTION COMPOSITION HAVING organopolysiloxane ORGANOPOLYSILOXANE HAVING AT LEAST ONE RADICAL VINYL A organohydropolysiloxane, CATALYST COMPLEX METAL PLATINUM GROUP AND AT LEAST ONE INHIBITORS WHICH IS ORGANIC COMPOUND allene WITH BOILING POINT OF AT LEAST 25C. THE COMPOSITIONS ACCORDING TO THE INVENTION ARE USED TO MAKE MATERIAL NOT aDHERE TO OTHER MATERIALS TO WHICH normally adhere.
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OBJECTIVE: To establish HPLC fingerprint of Compound danshen tablets.METHODS: The separation was performed on Agilent Eclipse XDB-C18(150 mm×4.6 mm,5μm) column with mobile phase consisted of acetonitrile-0.04% phosphate (gradient elution) at flow rate of 1.0 mL·min-1.Detection wavelength was set at 272 nm and column temperature was 30℃.RESULTS: Established HPLC fingerprint was distinct and reproducible.There were 8 characteristic peaks among which No.5 characteristic peaks,No.6,No.7,No.8 came from HPLC fingerprint of Salvia miltiorrhiza and No.1 characteristic peaks,No.2,No.3,No.4 came from HPLC fingerprint of Panax notoginseng.CONCLUSION: The characteristic peaks of effective parts of Compound danshen tablet mainly come from S.miltiorrhiza.The study can be used for tracing and isolation of effective part of Compound danshen tablet and establishes basis for the further development of Chinese patent drugs.
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eng_Latn
| 32,037 |
Aloin, cinnamic acid and sophorcarpidine are potent inhibitors of tyrosinase.
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OBJECTIVE ::: To evaluate the effects of aloin, cinnamic acid and 15 other kinds of natural chemicals on the activity of tyrosinase, in order to provide lightening agents in the treatment of hyperpigmentation disorders and cosmetic additives. ::: ::: ::: METHODS ::: Tyrosinase activity was estimated by measuring the oxidation rate of L-dopa. Inhibition of the enzyme was deduced according to the Lineweaver-Burk plots compared to the control. ::: ::: ::: RESULTS ::: Cadabine, paeonal, farrerol, evodin, cinnamic acid, aloin and sophorcarpidine had different levels of inhibition of tyrosinase. The inhibitory rates of cinnamic acid (2 mmol/L, 0.5 mmol/L), aloin (2 mmol/L) and the rest were significantly higher than that of hydroquinone (0.5 mmol/L) (P < 0.05). ::: ::: ::: CONCLUSIONS ::: Tyrosinase activity can be greatly inhibited by cinnamic acid, aloin and sophorcarpidine, of which sophorcarpidine functions as an uncompetitive inhibitor, compared to aloin and cinnamic acid, which are mixed-type inhibitors.
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An efficient one-pot method for the synthesis of tert-butyl 6-aminonicotinate (5) is described. The key transformation involves displacement of the chloro group in tert-butyl 6-chloronicotinate (2) with azide followed by a Staudinger reaction. The scope of this methodology is further extended for the synthesis of a series of carboxylate-substituted heteroaryl amines. In particular, we synthesized tert-butyl carboxylate-substituted amino-pyridine, -pyridazine, and -pyrazine. In addition to one-pot conversion, short reaction time, simplicity of operation, ease of purification, and good yields are the key advantages of this methodology.
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eng_Latn
| 32,038 |
Enantioselective synthesis of helicenequinones and -bisquinones
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A convergent approach based on Diels–Alder reactions between polycyclic dienes and benzoquinones has emerged as a powerful tool for the construction of helicenequinones and bisquinones. Chemical resolution and asymmetric Diels–Alder reactions with sulfinyl quinones provide direct access to enantiopure derivatives. Biaryl or ferrocenyl dienes can be resolved leading to helicenequinones having additional axial or planar chirality.
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OBJECTIVE: To establish HPLC fingerprint of Compound danshen tablets.METHODS: The separation was performed on Agilent Eclipse XDB-C18(150 mm×4.6 mm,5μm) column with mobile phase consisted of acetonitrile-0.04% phosphate (gradient elution) at flow rate of 1.0 mL·min-1.Detection wavelength was set at 272 nm and column temperature was 30℃.RESULTS: Established HPLC fingerprint was distinct and reproducible.There were 8 characteristic peaks among which No.5 characteristic peaks,No.6,No.7,No.8 came from HPLC fingerprint of Salvia miltiorrhiza and No.1 characteristic peaks,No.2,No.3,No.4 came from HPLC fingerprint of Panax notoginseng.CONCLUSION: The characteristic peaks of effective parts of Compound danshen tablet mainly come from S.miltiorrhiza.The study can be used for tracing and isolation of effective part of Compound danshen tablet and establishes basis for the further development of Chinese patent drugs.
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eng_Latn
| 32,039 |
Hybrid Use of Likert Scale-Based AHP and PROMETHEE Methods for Hazard Analysis and Consequence Modeling (HACM) Software Selection
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Being a decision-making process, software evaluation and selection is complicated, time-consuming, costly and also critical to the success of the project/work/organization. In this study, evaluatio...
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A ceramidase mixture comprising an inert acid ceramidase precursor and active acid ceramidase relates to therapeutic compositions comprising a pharmaceutically acceptable carrier. Also relates an acidic ceramidase used in acid ceramidase treatment, comprising the step of formulating as ceramidase mixture containing an inert acid ceramidase precursor and active acid ceramidase, to a method of acid ceramidase treatment. Further, step provides a medium containing inert acid ceramidase precursor; inert acidic incubating the medium under conditions effective to convert a portion of the ceramidase precursor into the active acid ceramidase; and incubated medium and including the step of recovering a ceramidase mixture containing an inert acid ceramidase precursor and active acid ceramidase, relates to a method of producing a therapeutic composition. Also it relates to the preparation of therapeutic compositions of the ceramidase lacking acidic sphingomyelinase.
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eng_Latn
| 32,040 |
Review of Ultra Versus U-Boats: Enigma Decrypts in The National Archives by Roy Conyers Nesbit
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Fungicidal mixtures, comprising a.1) a phenyl-benzylether of the formula I.a, I.b or I.c, or a.1) a carbamate of the formula I.d, where X is CH and N, n is 0, 1 or 2 and R is halogen, C1-C4-alkyl and C1-C4-haloalkyl, it being possible for the radicals R to be different when n is 2, and b) a dicarboximide-type fungicide (II) in a synergistically active amount.
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Bennett discusses Pomerance's proposal of bankrolling a new journal for Aegean archaeology. Bennett lays out the landscape of then-current periodicals for related topics, then goes on to describe what a new journal might contain and which house would publish it.
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eng_Latn
| 32,041 |
Curative effect observation of vitiligo treated with 0.01% Halometasone Cream and ammoodin
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Objective:To study the effects of 0.01% Halometasone Cream combined with ammoodin for vitiligo.Methods:According to random number table,120 patients were divided into two groups.Each group had 60 cases.The control group orally took ammoodin sep-arately,0.3-0.6 mg/(kg.d),at a time and once every three days and NB-UVB after taking the drug.The exposure intensity was suitable for the occurrence of the mild erythema and the patients wore dark glasses during the treatment.The treatment group added 0.01% Halometasone Cream.Two groups were followed up for 3 months after beginning.Results:The effective rates of the experimental group and control group were 73.33% and 45.0% respectively.Statistical significance was found between the two groups(P0.01).Conclusion: 0.01% Halometasone Cream combined with ammoodin is an effective method for the treatment of vitiligo.
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Various condensation products were obtained by the reaction between pyruvic acid and urea. They are 5-hydroxy-5-methyl-hydantoin, homoallantoin, homoallantoic acid, and dipyruvic triureide. 5-Methylene-hydantoin was prepared from some of these compounds, or directly from pyruvic acid and urea, by reactions in organic acid. The most convenient method was the dehydration of 5-hydroxy-5-methyl-hydantoin, which is a new compound melting at 166°C. 5-Methylene-hydantoin, m. p. 214°C, is a new monomer of the vinylidene type which polymerizes easily by means of a free radical mechanism. 3-Methyl-5-methylene-hydantoin was also prepared from 5-hydroxy-5-methyl-hydantoin through its 3-methyl derivative.
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eng_Latn
| 32,042 |
3-Dehydroquinate synthase in germinating Phaseolus mungo seedlings.
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Dehydroquinate synthase, an enzyme catalyzing the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to 3-dehydroquinate, was detected in cell-free extracts of etiolated Phaseolus mungo seedlings. The reaction product, 3-dehydroquinate, formed from [1-14C]DAHP was identified by paper-radiochromatography. The enzyme required NAD+ and Co2+ for activity.
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[Objective]To observe the Huangqi Guizhi Wuwu decoction the comprehensive acupuncture and moxibustion treatment of refractory peripheral facial paralysis clinical curative effect.[Methods]The author of the cure of 28 cases using five thing soups with Buyanghuanwu decoction of five traditional Chinese medicine decoction combined with acupuncture,scalp acupuncture,application,acupuncture and moxibustion,TDP irradiation,plum blossom needle cupping method,comprehensive treatment.[Results]Among the 28 cases,11 cases were cured,15 cases improved,2 cases are invalid,the total efficiency of 92.86%,[Conclusion] Huangqi Guizhi Wuwu decoction the integrated acupuncture treatment of intractable peripheral facial paralysis,curative effect satisfaction.
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eng_Latn
| 32,043 |
Development of an apparatus for mass-transfer studies in supercritical fluids
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A gravimetric analysis apparatus to measure the mass-transfer rates of solid solutes into supercritical solvents has been designed, built, and tested. The heart of the apparatus is a miniature thin film strain gauge load cell which measures the mass of a solid suspended in a flowing fluid continuously over the duration of the experiment. From knowledge of the geometry of the solute pellet, the mass flux at the surface interface is determined directly. In this work, mass flux data was collected for the dissolution of naphthalene into supercritical carbon dioxide at 35 and 55°C and at pressures ranging from 8359 to 12000 kPa. From the data, binary diffusion coefficients were calculated and compared with published values to verify the methodology. As the calculated values fall within the range of the published diffusion coefficients, the apparatus can be considered to have been verified successfully and is fully operational.
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Objective:To prepare total matrine controlled release micropellet capsules.Methods:The capsules were prepared by the technology of film-coating with surelease as matrix,and judged by the release behavior.Results:The drug had completely been coated into a homogeneous and continuous film,and the results repeated in three batches showed that the release behavior of the pellet capsules followed zero-equation.Conclusion:The capsules have good sustained release effect and the process of the preparation is available.
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eng_Latn
| 32,044 |
COMPARISON OFCAPTOPRILAND HYDROCHLOROTHIAZIDE ALONE AND INCOMBINATION INMILDTO MODERATE ESSENTIALHYPERTENSION
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was similar, while thecombination produced an additive responsegreater (p<O.OOl) thancaptopril orhydrochlorothiazide alone. 2 Themajorside effect reported was arashinfewer than6%ofpatients taking captopril alone orin combination. Lossoftaste orproteinuria wasnotobserved. 3 Theaddition ofcaptopril tohydrochlorothiazide blunted thehypokalaemia andhyperuricaemia observed withhydrochlorothiazide alone inaddition toitsantihypertensive synergy.Theseobservations indicate that this relatively lowdoseofcaptopril issafe andefficacious inthetreatment ofmildto moderate hypertension alone andparticularly whencombined with athiazide diuretic.
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FIELD: chemistry. SUBSTANCE: invention concerns process of production of diisopropyl {[1-(hydroxymethyl)-cyclopropyl]oxy}methylphosphonate represented by the formula , which is the key intermediate compound in synthesis of antiviral nucleoside analogue. The invention also concerns new intermediate compounds of formulae and , and their production of compound (2) obtained under this invention, which is an antiviral nucleoside analogue (especially against hepatitis B virus) represented by the formula . EFFECT: high purity grade and high output. 4 ex
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yue_Hant
| 32,045 |
Chitosan-based interpolymeric pH-responsive hydrogels forin vitro drug release
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Two series of pH-responsive biodegradable interpolymeric (IPN) hydrogels based on chitosan (Ch) and poly(vinyl alcohol) (PVA) were prepared for controlled drug release investigations. The first series was chemically crosslinked with different concentrations of glutaraldehyde and the second was crosslinked upon γ-irradiation by different doses. The equilibrium swelling characteristics were investigated for the gels at 37°C in buffer solutions of pH 2.1 and 7.4 as simulated gastric and intestinal fluids, respectively. 5-Fluorouracil (FU) was entrapped in the hydrogels, as a model therapeutic agent, and the in vitro release profiles of the drug were established at 37°C in pH 2.1 and 7.4. FTIR, SEM, and X-ray diffraction analyses were used to characterize and investigate the structural changes of the gels with the variation of the blend composition and crosslinker content before and after the drug loading. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 103: 2864–2874, 2007
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FIELD: chemistry. SUBSTANCE: invention concerns process of production of diisopropyl {[1-(hydroxymethyl)-cyclopropyl]oxy}methylphosphonate represented by the formula , which is the key intermediate compound in synthesis of antiviral nucleoside analogue. The invention also concerns new intermediate compounds of formulae and , and their production of compound (2) obtained under this invention, which is an antiviral nucleoside analogue (especially against hepatitis B virus) represented by the formula . EFFECT: high purity grade and high output. 4 ex
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eng_Latn
| 32,046 |
Synthesis of Differentially Substituted 2-Aminoimidazolidines via a Microwave-Assisted Tandem Staudinger/Aza-Wittig Cyclization
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A new route for the construction of 2-aminoimidazolidines including analogues of the α2 adrenergic agonist drug clonidine is elaborated. The key step is an intramolecular microwave-assisted Staudinger/aza-Wittig cyclization of an in situ generated urea intermediate (formed by the reaction of β-amino azide and isocyanate) upon treatment with Bu3P or polymer-supported phosphine reagent, allowing the introduction of various substituents at the N1 and the 2-amino function. Furthermore, a useful one-pot Staudinger/aza-Wittig/Buchwald–Hartwig protocol leading to bicyclic guanidines has been elaborated.
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OBJECTIVE: To establish HPLC fingerprint of Compound danshen tablets.METHODS: The separation was performed on Agilent Eclipse XDB-C18(150 mm×4.6 mm,5μm) column with mobile phase consisted of acetonitrile-0.04% phosphate (gradient elution) at flow rate of 1.0 mL·min-1.Detection wavelength was set at 272 nm and column temperature was 30℃.RESULTS: Established HPLC fingerprint was distinct and reproducible.There were 8 characteristic peaks among which No.5 characteristic peaks,No.6,No.7,No.8 came from HPLC fingerprint of Salvia miltiorrhiza and No.1 characteristic peaks,No.2,No.3,No.4 came from HPLC fingerprint of Panax notoginseng.CONCLUSION: The characteristic peaks of effective parts of Compound danshen tablet mainly come from S.miltiorrhiza.The study can be used for tracing and isolation of effective part of Compound danshen tablet and establishes basis for the further development of Chinese patent drugs.
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eng_Latn
| 32,047 |
Mechanism of the reaction of bis(α-hydroxyalkyl)phenyl-phosphine sulfides with dimethylformamide dimethylacetal
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The reaction of bis(α-hydroxyalkyl)phenylphosphine sulfides with dimethylformamide dimethylacetal proceeds with the formation of the O-methyl alkylphenylthiophosphinates.
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A process pachulol pruduccion and 7-epi-a-selinene comprising a) contacting farnesyl pyrophosphate (FPP) with at least one polypeptide having an activity pachulol and 7-epi-a-selinene synthase and comprising a amino acid sequence at least 70% identical to SEQ ID NO: 1; wherein said contacting is in vitro, or in vivo in a nonhuman organism or cell transformed to express said polypeptide; b) optionally isolating the 7-epi pachulol and-a-selinene produced in step a).
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eng_Latn
| 32,048 |
Serdica Math. J. 35 (2009), 287–300 CLASS NUMBER TWO FOR REAL QUADRATIC FIELDS OF RICHAUD-DEGERT TYPE
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This paper contains proofs of conjectures made in (16) on class number 2 and what this author has dubbed the Euler-Rabinowitsch polyno- mial for real quadratic fields. As well, we complete the list of Richaud-Degert types given in (16) and show how the behaviour of the Euler-Rabinowitsch polynomials and certain continued fraction expansions come into play in the complete determination of the class number 2 problem for such types. For some values the determination is unconditional, and for others, the wide Richaud-Degert types, the determination is conditional on the generalized Riemann hypothesis (GRH).
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Malaria is endemic in tropical and subtropical regions of Africa, Asia, and the Americas. The increasing prevalence of multi-drug-resistant Plasmodium falciparum drives the ongoing need for the development of new antimalarial drugs. In this light, novel scaffolds to which the parasite has not been exposed are of particular interest. Recently, workers at the Swiss Tropical Institute discovered two novel 4-oxo-3-carboxyl quinolones active against the intra-erythrocytic stages of P. falciparum while carrying out rationally directed low-throughput screening of potential antimalarial agents as part of an effort directed by the World Health Organization. Here we report the design, synthesis, and preliminary pharmacologic characterization of a series of analogues of 4-oxo-3-carboxyl quinolones. These studies indicate that the series has good potential for preclinical development.
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kor_Hang
| 32,049 |
The Determination of Benzoic Acid and Salicylic Acid Mixtures by Differential Nonaqueous Titration
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A method for the analysis of benzoic acid and salicylic acid mixtures is presented. The procedure is based upon the differential titration of the acids in dimethyl form-amide as solvent with sodium methoxide as titrant. Ointments containing the acid mixture are analyzed. Quantitative results are reported.
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Abstract Selective reductions of oxazolidinones using sodium borohydride and their application to the diastereoselective synthesis of vicinal amino alcohols are described.
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eng_Latn
| 32,050 |
Siderophore Biosynthesis Governs the Virulence of Uropathogenic Escherichia coli by Coordinately Modulating the Differential Metabolism
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Urinary tract infections impose substantial health burdens on women worldwide. Urinary tract infections often incur a high risk of recurrence and antibiotic resistance, and uropathogenic E. coli accounts for approximately 80% of clinically acquired cases. The diagnosis of, treatment of, and drug development for urinary tract infections remain substantial challenges due to the complex pathogenesis of this condition. The clinically isolated UPEC 83972 strain was found to produce four siderophores: yersiniabactin, aerobactin, salmochelin, and enterobactin. The biosyntheses of some of these siderophores implies that the virulence of UPEC is mediated via the targeting of primary metabolism. However, the differential modulatory roles of siderophore biosyntheses on the differential metabolomes of UPEC and non-UPEC strains remain incompletely understood. In the present study, we sought to investigate how the differential metabolomes can be used to distinguish UPEC from non-UPEC strains and to determine the associ...
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FIELD: chemistry. SUBSTANCE: invention concerns process of production of diisopropyl {[1-(hydroxymethyl)-cyclopropyl]oxy}methylphosphonate represented by the formula , which is the key intermediate compound in synthesis of antiviral nucleoside analogue. The invention also concerns new intermediate compounds of formulae and , and their production of compound (2) obtained under this invention, which is an antiviral nucleoside analogue (especially against hepatitis B virus) represented by the formula . EFFECT: high purity grade and high output. 4 ex
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eng_Latn
| 32,051 |
Preparation of the dispersible tablets of compound sucralfate and evaluating their quality
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Objective: To prepare the dispersible tablets of compound sucralfate and evaluate their quality. Methods: The formulation was screened by means of uniform design and the tablets were prepared by press the powder directly. Their disintegration, dissolution and suspension were determined and compared with those of the capsules. The stability of the dispersible tablets was investigated. Results: The performance of the prepared dispersible tablets was better than that of the capsules. The disintegration time of dispersible tablets and capsules was (1±0. 12) mm and (20±3. 93) mm, respectively. The dissolution rates of sucralfate and folic acid in dispersible tablets were 75% and 85% respectively in 5 mm, while those in capsules were all 10% in the same time. Conclusion: The dispersible tablets of compound sucralfate are stable in quality and are suitable for clinical application.
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(57) Abstract: cleaning composition as pseudoplastic and thixotropic liquid is disclosed. Suitable compositions of this type are produced in the form of an aqueous emulsion of nonionic surfactants. The cleaning method of the fabric and the surface, as well as package encapsulating said composition in a squeeze-type container equipped with a nozzle is disclosed.
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eng_Latn
| 32,052 |
Design and Development of a Low-Cost High-G Centrifuge System (Cyclone)
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High-G Centrifuge Systems provide a safe and controllable environment for G motion fields required for fighters’ pilots training. Lacking an operational Human Centrifuge System in Australia, the Institute for Intelligent Systems Research and Innovation (IISRI) at Deakin University has designed and built a low-cost High-G Centrifuge System, named Cyclone. Cyclone has the capability of generating a maximum sustained acceleration of 9G with an onset rate of 5G/sec. The system has an effective arm length of over 5m, which is actuated by a capable gear-motor. This paper addresses the main characteristics of Cyclone including modular design, self-balanced structure and rotating main drive. Moreover, the design and development of the system are discussed and the experimental results of two test scenarios will be presented. The developed system offers the highest level of operational and occupational safety to be rated as a human-capable system. The human-rating of Cyclone is currently investigated.
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Ab initio molecular orbital (SCF) calculations were performed on cubane, tetraazacubane, and their nitro derivatives. The group equivalent method was used to calculate strain energies. Such calculated values show that the substitution of carbons by nitrogen atoms in the cubane cage increases the strain energy at this level of theory. Increasing nitro substitution has a similar effect and this is more pronounced in the tetraazacubane system.
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eng_Latn
| 32,053 |
Process for the preparation of a ruthenium-in-Denis isopropylidene complex
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The present invention is directed to a method for preparing a ruthenium catalyst This method, the precursor compound The product is obtained as a high crystallinity and purity cyclic ether solvate.
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In this article, perspective using of the laser deposition method for manufacture details from the titanium alloy VT20 is considered. Dependence on a structure of the fractional composition is shown. Study of the structure and properties of parts, which were produced by DLD technology using different modes and under different conditions.
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eng_Latn
| 32,054 |
Determination of amoxycillin in amoxycillin oral suspension by HPCE
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Objective: to determine the content of amoxycillin in amoxycillin oral suspension. Methods: HPCE was used. The best condition was achieved with a fused silca capillary tube (60 cm × 75μm) , 30 mmol/L sodium tetraborate decahydrate buffer ( pH 9. 2) , at a constant voltage of 12 kV and temperature at 25℃. The UV detection wavelength was at 254 nm and ferulic acid was determinaed with internal standard method. Results: the calibration curves was linear in the range of 4 -20 μg/mL for amoxycillin( r = 0. 9997) . The average recovery of amoxycillin was 99. 10% ( n =5 ,RSD= 1. 89% ) . Conclusions: this method is simple, quick and sensitive.
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Direct synthesis of organic azides from alcohols was developed. Azide transfer of 2-azido-1,3-dimethylimidazolinium hexafluorophosphate (ADMP) to alcohols proceeds to give the corresponding azides under mild reaction conditions, which were easily isolated because the byproducts are highly soluble in water.
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eng_Latn
| 32,055 |
Diagnostic Genetic Testing for Monogenic Diabetes and Congenital Hyperinsulinemia.
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Monogenic diabetes and hyperinsulinism are genetically heterogeneous disorders. The determination of the genetic etiology defines the diagnostic subtype, predicts prognosis, and importantly can guide clinical management. This chapter focuses on the processes and methodologies utilized in the diagnostic testing for monogenic diabetes and congenital hyperinsulinism (i.e., Sanger sequencing and targeted next-generation sequencing).
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The present invention relates to a method for checking CMIs trace resin is in the field of traditional Chinese medicine injection safety evaluation. The method of the present invention, first the principle of molecular sieve macromolecular species in traditional Chinese medicine injections different degrees enriched enriched liquid prepared macromonomer, further enriched liquid inspection macromolecules, i.e. the residue obtained was extracted with chloroform, and then glacial acetic acid check solubility residue; to facilitate the observation result, the need of glacial acetic acid is centrifuged, the traditional Chinese medicine injections can check the presence of a resin, the sensitivity is significantly higher than the "Chinese Pharmacopoeia" method. By adjusting the sample volume and the enrichment ratio can be easily checked for sensitivity adjustment to check for resin injection particular medicine can be used for safety evaluation of TCM injections.
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eng_Latn
| 32,056 |
EXPERIMENTAL OBSERVATION ON GERMICIDAL EFFICACY OF COMPOUND CHLORHEXIDINE ACETATE DISINFECTANT
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In order to know the germicidal efficacy of compound chlorhexidine acetate disinfectant,suspension quantitative germicidal test and field trial were used to carry out experimental observation.Results: The killing logarithm values of Staphylococcus aureus and Escherichia coli exposed to the stock solution of the compound disinfectant containing chlorhexidine acetate 1540 mg/L for 3 min were 5.0.Spraying moistening disinfection of hands and forearms with the disinfectant for 2～3 min could kill the natural bacteria by a logarithm 1.0 in average.Aerosol spraying disinfection of a 45 m~3 room with the stock solution of the disinfectant at a dosage of 8 ml/m~3 for 30 min caused 97.5% eradicating rate of natural bacteria in air.After the stock solution of the disinfectant was stored in sealed contition at 37℃ for 90 days,its chlorhexidine acetate content decreased by 1.94%.Conclusion: The disinfectant is stable and has good efficacy in killing vegetative forms of bacteria and natural bacteria on skin.
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PURPOSE: A novel method for preparing entecavir and a novel intermediate used for the same are provided to easily produce a large amount of novel intermediates. CONSTITUTION: A method for preparing entecavir of chemical formula 1: a step of hydrolyzing alpha-exomethylene compound of chemical formula 2 to synthesize a compound of chemical formula 3; a step of reacting the compound of chemical formula 3 with a purine compound of chemical formula 4 by Mitsunobu reaction to obtain a nucleoside compound of chemical formula 5; a step of reacting the compound of chemical formula 5 with tetrabutyl ammonium fluoride to obtain a compound of chemical formula 6; and a step of hydrolyzing the compound of chemical formula 6.
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yue_Hant
| 32,057 |
Solifenacin: a new drug for the treatment of overactive bladder and detrusor overactivity
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Overactive bladder is a prevalent and debilitating condition that affects many people. Drugs play a major role in treatment, together with bladder training and behavioral measures. Drugs are aimed at controlling the symptoms of overactive bladder, such as frequency, nocturia, urgency and urgency incontinence, preferably with as few side effects as possible. Solifenacin is a novel muscarinic receptor antagonist. It shows greater selectivity for the urinary bladder over salivary glands than tolterodine, oxybutinin and darifenacin. Solifenacin is long acting and therefore oral intake once-daily is sufficient. It can improve all symptoms of overactive bladder and results can be seen early into the treatment course. Dose adjustment is possible if needed. Long-term efficacy has been demonstrated.
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Abstract Two methods for calculating activity coefficients of ultra-low sulfur diesel (ULSD) and its blends with pure alcohols (C1–C5), namely, UNIFAC-continuous and UNIFAC-Dortmund-continuous, are presented. ULSD was modeled as a continuous blend of paraffins, naphthenes, and aromatics. The molar distribution in each family was expressed as a function of carbon number using the gamma distribution function. The parameters of the distribution function can be easily fitted from experimental distillation data of ULSD and extrapolated to n-alcohol/ULSD blends. The activity coefficients obtained were used to model the ASTM D86 distillation curves. UNIFAC-Dortmund-continuous exhibited the best fitting to the experimental results. Based on that, three new correlations for calculating the boiling point, vapor pressure and structural groups of complex ULSD are proposed here.
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eng_Latn
| 32,058 |
Liquid helium cryostat with internal fluorescence detection for x-ray absorption studies in the 2-6 keV energy region.
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X-ray absorption spectroscopy (XAS) in the intermediate x-ray region (2–6 keV) for dilute biological samples has been limited because of detector/flux limitations and inadequate cryogenic instrumentation. We have designed and constructed a new tailpiece/sample chamber for a commercially available liquid helium cooled cryostat which overcomes difficulties related to low fluorescence signals by using thin window materials and incorporating an internal photodiode detector. With the apparatus, XAS data at the Cl, S, and Ca K edges have been collected on frozen solutions and biological samples at temperatures down to 60 K. A separate chamber has been incorporated for collecting room-temperature spectra of standard compounds (for energy calibration purposes) which prevents contamination of the cryostat chamber and allows the sample to remain undisturbed, both important concerns for studying dilute and radiation-sensitive samples.
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The invention discloses a synthesizing method of trioxymethylene. The method comprises the following step that: formalin is reacted under the catalysis of ionic liquid, and then the trioxymethylene is obtained, wherein the percentage by weight of the formalin is 30-70%. A catalyst used in the method disclosed by the invention is easy to prepare, and has high catalytic activity, the concentration of the trioxymethylene in reaction liquid is higher, the contents of methanal, methanoic acid, methylal and other by-products are low, and the selectivity of a product is better; the application scope of the concentration of the methanal material is wide and is 30-70 wt%, and the reaction condition is mild; the dosage of the ionic liquid catalyst is small and is 0.05-10 wt%; and the catalyst has good heat stability and can be recycled.
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eng_Latn
| 32,059 |
Direct Synthesis of Organic Azides from Alcohols Using 2-Azido-1,3-dimethylimidazolinium Hexafluorophosphate
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Direct synthesis of organic azides from alcohols was developed. Azide transfer of 2-azido-1,3-dimethylimidazolinium hexafluorophosphate (ADMP) to alcohols proceeds to give the corresponding azides under mild reaction conditions, which were easily isolated because the byproducts are highly soluble in water.
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Aim To develop a method for determination of hydroxyl safflor yellow A in Xiaoyuzhitong Qiwuji.Methods RP-HPLC with ZORBAX SB-C18(250mm×4.6mm,5μm)column was used. The mobile phase consisted of methanol-acetonitrile-0.2% acetic acid (26∶2∶72), with a flow rate of 1.0ml/min and detection wavelength at 403nm,under 40℃. Results The linear range was 0.396 9～2.116 8μg (r=0.999 6),the average recovery (n=6) was 98.43% and the relative standard deviation,RSD,was 1.81%.Conclusion The method is simple ,fast and applicable to the analysis of Xiaoyuzhitong Qiwuji of different sources .It can also be used for quality control of safflower preparations for clinical use.
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eng_Latn
| 32,060 |
CCDC 1568709: Experimental Crystal Structure Determination
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Related Article: Gummadi Durgaprasad, Javier A. Luna, Kyle D. Spielvogel, Christian Haas, Scott K. Shaw, Scott R. Daly|2017|Organometallics|36|4020|doi:10.1021/acs.organomet.7b00623
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The present invention relates to a method for checking CMIs trace resin is in the field of traditional Chinese medicine injection safety evaluation. The method of the present invention, first the principle of molecular sieve macromolecular species in traditional Chinese medicine injections different degrees enriched enriched liquid prepared macromonomer, further enriched liquid inspection macromolecules, i.e. the residue obtained was extracted with chloroform, and then glacial acetic acid check solubility residue; to facilitate the observation result, the need of glacial acetic acid is centrifuged, the traditional Chinese medicine injections can check the presence of a resin, the sensitivity is significantly higher than the "Chinese Pharmacopoeia" method. By adjusting the sample volume and the enrichment ratio can be easily checked for sensitivity adjustment to check for resin injection particular medicine can be used for safety evaluation of TCM injections.
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kor_Hang
| 32,061 |
Synthesis of the spiroketal core of integramycin
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A concise synthetic strategy towards the spiroketal core of the HIV-integrase inhibitor integramycin (1) was developed. The required ketone precursor was efficiently constructed from two simple and easily accessible subunits by means of a hydrozirconation/copper catalyzed acylation reaction. The effects of different protecting groups on the spiroketalization step were also investigated.
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Objective To study the best extracting technology of Compound Taizishen Granule prescription.Methods The total polysaccharides and total saponins were determined by UV spectrophotometer.With the content of total polysaccharides and total saponins as comprehensive indexes,orthogonal test was applied to investigation of the water addition,extraction time,and extraction times for optimizing the best extracting technology.Results The best extracting technology was using 10 times the amount of water,extracting 3 times and 1.5 h per time.Conclusion The extraction technology is safe and effective,which can be used as extraction for Compound Taizishen Granule prescription.
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eng_Latn
| 32,062 |
Determination of Emodin in Qihuang capsules by HPLC
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Objective:To establish a method for the determination of Emodin in Qihuang capsules using a solid - phase extraction and reversed -phase HPLC.Methods :The sample was treated with ODS - C18 solid - phase extraction column,Zorbax SB - C18 column(4.6mm × 250mm,5um) was used,MeOH- 0.1%H_3PO_4(90:10)were served as mobile phase with 1.0mL·min~(-1) flow rate.The detection wavelength was 254nm.Results: Emodin concentration presented a good linear range of 1.0 - 5.0μg(r = 0.9999),the average recovery was 100.31%,RSD = 2.36%.Conclusion: This method is rapid,simple and accurate.
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The volatile components in 11 cigarette samples were analyzed with SDE-GC/MS, and cluster analysis of 90 component peaks were carried out with SPSS software according to Euciolidiam distance group-average coefficient method. The results showed that the 11 cigarette samples could be grouped into 6 categories exactly corresponding to their respective brands and producers, namely, the cigarettes of the same brand and manufactured by the same factory would be well grouped into the same category. The method provides reference for brand distinguishing, quality control, comprehensive evaluation and authenticity discrimination.
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eng_Latn
| 32,063 |
Synthesis and Properties of Samarium Complex with 3,5-Dinitrobenzoic Acid Ligand and 1,10-Phenanthroline and Its Interaction with Ct-DNA
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Samarium complex based on 3,5-dinitrobenzoic acid and 1,10-phenanthroline was synthesized by the solution synthetic method. The composition of the title complex was confirmed to be Sm( L)3phen( HL = 3,5-dinitrobenzoic acid;phen = 1,10-phenanthroline) by means of elemental analysis,coordination titration,molar conductivity,IR and UV spectra.The properties of the title complex were investigated by means of thermal analysis and electrochemical method. The interaction between complex and Ct-DNA was investigated by viscometry. The results showed that the binding mode of the complex with Ct-DNA was intercalation.
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OBJECTIVE: To establish HPLC fingerprint of Compound danshen tablets.METHODS: The separation was performed on Agilent Eclipse XDB-C18(150 mm×4.6 mm,5μm) column with mobile phase consisted of acetonitrile-0.04% phosphate (gradient elution) at flow rate of 1.0 mL·min-1.Detection wavelength was set at 272 nm and column temperature was 30℃.RESULTS: Established HPLC fingerprint was distinct and reproducible.There were 8 characteristic peaks among which No.5 characteristic peaks,No.6,No.7,No.8 came from HPLC fingerprint of Salvia miltiorrhiza and No.1 characteristic peaks,No.2,No.3,No.4 came from HPLC fingerprint of Panax notoginseng.CONCLUSION: The characteristic peaks of effective parts of Compound danshen tablet mainly come from S.miltiorrhiza.The study can be used for tracing and isolation of effective part of Compound danshen tablet and establishes basis for the further development of Chinese patent drugs.
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eng_Latn
| 32,064 |
TOPICAL VERSUS CONTINUOUS BETAMETHASONE DIPROBIONATE PHONOPHORESIS IN THE TREATMENT OF ATOPIC DERMATITIC PATIENTS
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Purpose: The purpose of this study was to compare Topical versus Continuous Betamethasone Diprobionate Phonophoresis in the Treatment of Atopic Dermatitic Patients ::: Methods: Forty six patients atopic dermatitis were participated in this study and were randomly assigned to one of two groups. Phonophoresis group received continuous 0.05% betamethasone dipropionate phonophoresis, three sessions per week for 4 weeks, and control group received topical betamethasone dipropionate cream daily. Measurements were carried out by ultrasonography and SCORAD score. ::: Results: results revealed that there was a significant difference between both groups as regard to primary outcomes ( SCORAD score) as well as secondary outcomes ( skin thickness measurements). ::: Conclusion: it was concluded that continuous betamethasone diprobionate phonophoresis is a safe and effective modality more than topical cream for the treatment of atopic dermatitis.
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FIELD: chemistry. SUBSTANCE: invention concerns process of production of diisopropyl {[1-(hydroxymethyl)-cyclopropyl]oxy}methylphosphonate represented by the formula , which is the key intermediate compound in synthesis of antiviral nucleoside analogue. The invention also concerns new intermediate compounds of formulae and , and their production of compound (2) obtained under this invention, which is an antiviral nucleoside analogue (especially against hepatitis B virus) represented by the formula . EFFECT: high purity grade and high output. 4 ex
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yue_Hant
| 32,065 |
Effect of ricin or ricin A-chain encapsulated in anti-carcinoembryonic antigen (CEA) antibody-bearing liposomes on CEA-producing tumor cells.
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Small and large liposomes containing ricin or ricin A-chain (a toxic subunit of ricin) and having monoclonal anti-carcinoembryonic antigen (CEA) antibodies on the surface were prepared, and their effects on CEA-producing tumor cells, were examined in order to evaluate the efficacy of these liposomes as drug delivery systems. It was found that the large unilamellar liposomes (average diameter : 3000 A) could not be internalized by the tumor cells, but were ruptured after specific binding to tumor cells through the monoclonal antibodies on the surface. On the other hand, the small unilamellar liposomes (average diameter : 800 A) were found to be easily internalized by tumor cells.
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The present invention relates to a method for checking CMIs trace resin is in the field of traditional Chinese medicine injection safety evaluation. The method of the present invention, first the principle of molecular sieve macromolecular species in traditional Chinese medicine injections different degrees enriched enriched liquid prepared macromonomer, further enriched liquid inspection macromolecules, i.e. the residue obtained was extracted with chloroform, and then glacial acetic acid check solubility residue; to facilitate the observation result, the need of glacial acetic acid is centrifuged, the traditional Chinese medicine injections can check the presence of a resin, the sensitivity is significantly higher than the "Chinese Pharmacopoeia" method. By adjusting the sample volume and the enrichment ratio can be easily checked for sensitivity adjustment to check for resin injection particular medicine can be used for safety evaluation of TCM injections.
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eng_Latn
| 32,066 |
Review of Industrial Application of Lurgi MTP Technology
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Industrial application of Lurgi's methanol to propylene(MTP) technology in the industrial field was reviewed.The characteristics of MTP technology and its problems exposed in industrial application were analyzed.It was necessary to constantly optimize and improve the MTP technology in the actual operation.On the one hand,the catalyst for high propylene yield and strong carbon deposition resistance was needed to develop.On the other hand,the existing process should be optimized to reduce energy consumption and improve the operability and to speed up its large-scale application at home and abroad.
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In this paper, a new distribution system for Chinese medicine is described. The system is devided into two layers,a PC is used in up layer for supervising of message and control, a PLC is used in bottom layer for controlling task. A special medicine\|down mechnism,distributing robot and control system are also introduced.
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eng_Latn
| 32,067 |
Reactions of cyclohexadienes and cyclohexene in the presence of a polyethylenimine complex of palladium dichloride
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The authors report the results of a study of the catalytic properties of a macromolecular complex between PEI and palladium dichloride in the hydrogenation and disproportionation reactions of cyclohexene, 1,3-cyclohexadiene, and 1,4cyclohexadiene. The kinetic curves of the disproportionation of 1,3-CHD in the presence of 1-hexyne are given. Cyclohexane and benzene were not detected in the reaction mixture. These results demonstrate that disproportionation does not occur under hydrogenation conditions.
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OBJECTIVE: To establish HPLC fingerprint of Compound danshen tablets.METHODS: The separation was performed on Agilent Eclipse XDB-C18(150 mm×4.6 mm,5μm) column with mobile phase consisted of acetonitrile-0.04% phosphate (gradient elution) at flow rate of 1.0 mL·min-1.Detection wavelength was set at 272 nm and column temperature was 30℃.RESULTS: Established HPLC fingerprint was distinct and reproducible.There were 8 characteristic peaks among which No.5 characteristic peaks,No.6,No.7,No.8 came from HPLC fingerprint of Salvia miltiorrhiza and No.1 characteristic peaks,No.2,No.3,No.4 came from HPLC fingerprint of Panax notoginseng.CONCLUSION: The characteristic peaks of effective parts of Compound danshen tablet mainly come from S.miltiorrhiza.The study can be used for tracing and isolation of effective part of Compound danshen tablet and establishes basis for the further development of Chinese patent drugs.
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eng_Latn
| 32,068 |
Preparation of Pyranose‐Based Thioimidate N‐Oxides (TINOs)
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The synthesis of new pyranose-based thioimidate N-oxides (TINOs) is reported. Original strategies were developed, by taking advantage of the nucleophilic capability of the thiohydroximate function, anchored on a carbohydrate backbone. The key cyclisation step was achieved either through a Mitsunobu-type reaction or through desilylative cyclisation. These studies enable access to a unique family of polyhydroxypiperidine thioimidate N-oxides both from aldopentoses (D-xylose and D-arabinose) and from aldohexoses (D-glucose, D-mannose), thus extending the previously relatively limited class of cyclic six-membered nitrone analogues. Typical examples of TINOs were prepared with good yields in six to ten steps in both D- and L-series. These compounds should be highly valuable synthetic intermediates in the preparation of various complex iminosugars, or azasugars, as potential modulators of carbohydrate-processing enzymes.
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Objective To study the best extracting technology of Compound Taizishen Granule prescription.Methods The total polysaccharides and total saponins were determined by UV spectrophotometer.With the content of total polysaccharides and total saponins as comprehensive indexes,orthogonal test was applied to investigation of the water addition,extraction time,and extraction times for optimizing the best extracting technology.Results The best extracting technology was using 10 times the amount of water,extracting 3 times and 1.5 h per time.Conclusion The extraction technology is safe and effective,which can be used as extraction for Compound Taizishen Granule prescription.
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eng_Latn
| 32,069 |
Technology Transfer in Pharmaceutical Manufacturing - A Review
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Technology Transfer (TT) is vital action from drug development in Research and Development (R and D) Department to commercial manufacturing till the product discontinuation. This review is an attempt to give an insight about the transfer of pharmaceutical product from R and D to production including necessary documents required to review the supporting documents and execution procedures in production shop floor. TT is considered effective, if there is a documented evidence that the process and its parameters, repeatedly results in desired product quality which was established upon during TT between the transferee and transferor. For the execution of TT process, expertise from different department such as Engineering, R and D, QA, process analyst and production are teamed. the transmission comprises of arrangements procured ::: in these flows of improvement to achieve the quality as planned throughout manufacture.
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*Orthopedics and Traumatology Surgery, Head of Orthopedics and Traumatology Surgery, Hospital de Denia Marina Salud, Partida Beniadla, S/N, Denia, Alicante, Pharm D. Pharmacy Service, Hospital Dr Moliner, Porta Coeli s/n Serra, Valencia, Doctor of Pharmacy Program, University of Granada, Pharm D. Head of Pharmacy Service, Hospital de Denia Marina Salud, Partida Beniadla, S/N, Denia, Alicante, Ophtalmologic Department, Hospital Virxen da Xunqueira, Cee, A Coruna, Spain Letter to the Editor Hand Surgery 2015;20(2):333-334 • DOI: 10.1142/S0218810415200038
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eng_Latn
| 32,070 |
Chinese medicine preparation for curing orthopaedics sickness
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The present invention discloses a traditional Chinese medicine preparation for the treatment of bone disease, the frankincense, myrrh, Eupolyphaga, natural copper, notoginseng, safflower, blood, peach, Eucommia, angelica, papaya processing technology by traditional Chinese medicine made formulations, indications shoulder lumbar disc protrusion, osteoarthritis, cervical spondylosis, frozen, arthritis, rheumatoid arthritis, old fractures, orthopedic tenosynovitis and other diseases. The present invention is made use of pure Chinese herbal preparation, drug side effects, treating the symptoms, a significant effect, clinical symptoms disappear quickly, no rebound phenomenon after healing.
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On the basis of the organic chemistry bachelor thesis,according to the personal training and the study feature of Changzhou University,some useful innovation idea and methods were analyzed and concluded with the combination of organic chemistry reform experience.These methods and idea were help to mobilize the enthusiasm and initiative of participating in the experiment and to promote the students' practical ability.
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eng_Latn
| 32,071 |
DIRECT CONSTRUCTION OF QUATERNARY CARBONS FROM CARBONYL COMPOUNDS UTILIZING LOW-VALENT VANADIUM COMPLEXES
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Abstract Direct geminal diallylation of a carbonyl compound with allyl bromide has been achieved in the presence of a low-valent vanadium complex and zinc. The diallylation has been found to proceed stepwise and the two allyl groups were introduced successively. By applying this method, one-pot synthesis of asymmetric quaternary carbons has been accomplished. As the first alkylating reagent a combination of allyl bromide and zinc, a Grignard reagent, or an alkyllithium can be used. The second one should be the combination of a low-valent vanadium(II) complex and allyl bromide, benzyl bromide, or propargyl bromide. Strong oxophilicity of the low-valent vanadium facilitated the deoxygenative allylation.
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Contact immunotherapy is an increasingly used, effective means of treating cutaneous viral warts. Dinitrochlorobenzene, diphencyprone, and squaric acid dibutylester are the most frequently used modalities, showing slight variances in adverse effect profiles and efficacy. All of these agents serve as safe treatment modalities when administered according to the guidelines recommended herein. We review the value of contact immunotherapy in the treatment of cutaneous viral warts.
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yue_Hant
| 32,072 |
Quantitative diagnosis of fatty liver with dual-energy CT: An experimental study in rabbits
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Objectives: To explore the correlation between fatty content of fatty liver and the difference of CT attenuation value in dual-energy CT, and to evaluate the value of dual-energy CT in the quantitative diagnosis of fatty liver in rabbits.Material and Methods: Dual-energy CT at 120 kVp and 90 kVp was performed in 16 rabbits of experimental groups that were induced to various degrees of fatty liver by feeding carbon tetrachloride (CCl4). Four healthy rabbits in the control group underwent dual-energy CT at the same time. The CT attenuation values of liver tissues at 120 kVp (H120), 90 kVp (H90) and the difference (ΔH) between them were obtained. The specimens of liver tissues were examined with freeze section (9 μm) and an oil red O stain histologically. The ratio of fatty content in liver to the liver volume (VP value) was measured using the image analyzer system.Results: The change of CT attenuation values between 120 kVp and 90 kVp was not obvious (ΔH between −0.4 HU and 1.4 HU) in the control group. The...
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Objective To evaluate the features and quality of the literatures on integrated therapy with traditional Chinese medicine and Western medicine for patients with chronic hepatitis B.Methods Searching strategy was made according to Cochrane systematic review and the related information of the literatures which met the criteria for inclusion was gathered.Results 141 literatures met the criteria for inclusion.29 sorts of Chinese medicinal herbs and 47 integrated therapies with traditional Chinese medicine and Western medicine were reported in these literatures.Methodological quality was identified inadequate in the literatures except two.Conclusion The methodological quality of the literatures on integrated therapy with traditional Chinese medicine and Western medicine needs to be further improved although the quantity is ideal.
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eng_Latn
| 32,073 |
Discuss on argy-bargy phenomenon from the current medical malpractice appraisal
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The medical dispute was a difficult problems of hospital development, the argy-bargy phenomenon was very stern at present. The medical malpractice identification was the main program of processing the medical disputes. It was the basis for the administration of public health department and the People's court to solve the medical dispute. In the practice the current medical malpractice identification system exposes a lot of drawbacks. It was important to set up a reasonable, perfect and highly recognized medical malpractice identification system for treating medical dispute smoothly. The article discussed how to build harmonious the doctor-patient relationship and prevent argy-bargy phenomena.
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The mixture infection of PCV-2 and multiple-bacteria has been common recently.It is hard to prevent the disease due to the lack of vaccine and medicine.The author of the paper,therefore,adopted the method of the Chinese herbal compound for the experimental treatment of the infected pigs,and achieved a satisfactory result.The result showed that the Chinese herbal compound had the characteristics of short curative duration,excellent effect and high cure rate.
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eng_Latn
| 32,074 |
Analysis on the Clinical Effect of Ephedra
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Ephedra,a kind of traditional Chinese medicine,its pharmacological actions and side effects have drawn people's attention.Doctors in the past used ephedra to treat disease of exogenous wind-cold,cough,asthma and edema.They think ephedra has strong effect on inducing sweat and dispelling exogenous evils.According to literature,ephedra has the nature of pungent and warm,could dispel wind and remove dampness,warm channel and expel cold,remove obstruction in collaterals.Thus,ephedra can be widely used in correct syndrome differentiation and exact combination of Chinese materia medica guarantee the wise application of ephedra for arthromyodynia,depression and other diseases.
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A typical Sharpless catalytic asymmetric dihydroxylation (ADH) process to make methyl (2R,3S)-2,3-dihydroxy-3 phenylpropionate has been successfully developed. The ADH reaction was exothermic and complete in 2−3 h without affecting the optical purity and yield. The major impurity of methyl (2R)-hydroxy-3-keto-phenylpropionate, which may seriously damage the quality of diol, has been identified and removed properly in the process.
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eng_Latn
| 32,075 |
Can you replace effectox with paxil?
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Can you take paxil and deprenyl together?
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What will happen if you use the wrong extingusher on the wrong fire?
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eng_Latn
| 32,076 |
Are cough medicenes alchohol based?
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Are many cough medicines alcohol bases?
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Are many cough medicines alcohol bases?
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eng_Latn
| 32,077 |
Why does Pine-Sol crystallize? How can this be avoided?
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Why does Pine-Sol crystallize?
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Will the creto method get me to pass a drug screen tomarrow if I used meth today?
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eng_Latn
| 32,078 |
During the decade, he discovered lysisine, an antibiotic enzyme, as well as penicillin
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penicillin facts, information, pictures | Encyclopedia.com articles ... Penicillins are a group of closely related antibiotics that kill bacteria. ... which protect the penicillin from bacterial enzymes that may destroy it before it can do its work. ... These preparations must be shaken well before use and measured with a ... Penicillin should not be used in patients allergic to the drug; however, an...
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jeopardy/38_Qs.txt at master jedoublen/jeopardy GitHub POTENTATE POTABLES | This Dutch-born English king introduced gin to England as the "pouring spirit" in the palace at Hampton Court | William III. right: Adam.
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eng_Latn
| 32,079 |
what happens when you put cocaine into a pint?, does it emulsify?
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it either ruins your pint....... or ruins your cocaine..... depending on your train of thought.................
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So you need chlorobutane to run a column?\n\nWhat about something similar, in terms of polarity, like chloropropane or chloropentane?\n\nI was going to run a column once based on results from TLC using a pentane/acetone mixture. The lab ran out of pentane and the stock room was closed. My undergraduate research advisor suggested hexane instead. We tried it, it worked, and I was able to get the separation.
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eng_Latn
| 32,080 |
does your trusted pharmacy's robotics contain mixed drug lots?
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ask the guy who loaded them. They shouldn't though
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This is the FDA's website that compares namebrand and generic medication. Most of the generic and namebrands are the therapeutically equivalent.\n\nhttp://www.fda.gov/cder/ob/default.htm\n\nClick on search by active ingredient, type in phenytoin, then click search. You can read about the codes by clicking on TE codes at the top.
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eng_Latn
| 32,081 |
wat exactly is the purpose of the xylem vessel and phloem tube in the transverse section of a leaf, and how does this help wit photosynthesis? dis is not h/w by the way
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When the roots absorb the water it goThe xylem takes also part in food storage, support and the conduction of minerals. Xylem and phloem together form a continuous system of vascular tissue extending throughout the plant. The principal conductive cells of the xylem are tracheary elements, of which there are two types, tracheids and wood vessels. Both are elongated cells with secondary cell walls that lack protoplasts at maturity. They are completed by the xylem fibres and parenchyma cells. Much speaks on behalf of the origin of xylem fibres and wood vessels from the tracheids. \n\nSince 1851, the isolation and depiction of lignified cells is done according to the maceration procedure of SCHULZE. Small pieces of wood are covered with a mixture of potassium perchlorate and concentrated nitric acid. The complete volume should not be larger than 1/10 of the reaction container, because a lot of gas develops very quickly at cautious heating. The surfaces of the wooden pieces are strongly attacked. The single cells can be scraped off after washing of the preparation and examined under the microscope.
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I've been in drug trials before. You need to present alot more information here for anyone to advise. Also, and more importantly, YOU need more information before you can make a decision. I'm not sure about your country, but in the US we require full disclosure of the drug. This would include, but not be limited to, information on the name, use, dose, side effects, pregnancy data, cytotoxic data, duration, etc.....of the drug. BTW, it narrows arteries???Are you sure it doesn't widen or dilate arteries?? Unless it's some kind of presser, I would think you would want dilation. Get a copy of all the paperwork about the drug and call your doctor. Ask them if they would do it.
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eng_Latn
| 32,082 |
BACKGROUND Good-quality artemisinin drugs are essential for malaria treatment, but increasing prevalence of poor-quality artemisinin drugs in many endemic countries hinders effective management of malaria cases.
METHODS To develop a point-of-care assay for rapid identification of counterfeit and substandard artemisinin drugs for resource-limited areas, we used specific monoclonal antibodies against artesunate and artemether, and developed prototypes of lateral flow dipstick assays. In this pilot test, we evaluated the feasibility of these dipsticks under different endemic settings and their performance in the hands of untrained personnel.
RESULTS The results showed that the dipstick tests can be successfully performed by different investigators with the included instruction sheet. None of the artemether and artesunate drugs collected from public pharmacies in different endemic countries failed the test.
CONCLUSION It is possible that the simple dipstick assays, with future optimization of test conditions and sensitivity, can be used as a qualitative and semi-quantitative assay for rapid screening of counterfeit artemisinin drugs in endemic settings.. Title: Pilot testing of dipsticks as point-of-care assays for rapid diagnosis of poor-quality artemisinin drugs in endemic settings
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Artemisinin-based combination therapies are the frontline treatment of Plasmodium falciparum malaria. The circulation of falsified and substandard artemisinin-based antimalarials in Southeast Asia has been a major predicament for the malaria elimination campaign. To provide an update of this situation, we purchased 153 artemisinin-containing antimalarials, as convenience samples, in private drug stores from different regions of Myanmar. The quality of these drugs in terms of their artemisinin derivative content was tested using specific dipsticks for these artemisinin derivatives, as point-of-care devices. A subset of these samples was further tested by high-performance liquid chromatography (HPLC). This survey identified that > 35% of the collected drugs were oral artesunate and artemether monotherapies. When tested with the dipsticks, all but one sample passed the assays, indicating that the detected artemisinin derivative content corresponded approximately to the labeled contents. However, one artesunate injection sample was found to contain no active ingredient at all by the dipstick assay and subsequent HPLC analysis. The continued circulation of oral monotherapies and the description, for the first time, of falsified parenteral artesunate provides a worrisome picture of the antimalarial drug quality in Myanmar during the malaria elimination phase, a situation that deserves more oversight from regulatory authorities.. Title: Quality Testing of Artemisinin-Based Antimalarial Drugs in Myanmar.
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Falciparum malaria kills, and it particularly kills the rural poor. Artemisinin derivatives, such as artesunate, are a vital component of Plasmodium falciparum malaria treatment and control in the face of globally increasing antimalarial drug resistance. Since 1998 a worsening epidemic of sophisticated counterfeit “artesunate” tablets (containing no artesunate) has plagued mainland Southeast Asia (see Figure S1). In some countries, most of the available artesunate is fake [ 1–5]. Artemisinin derivatives are remarkably rapid in their antimalarial effects, and they are very well tolerated. So where these medicines are available, they are sought after. But as they are relatively expensive, a demand is created for cheaper versions amongst the poorest and most vulnerable people, upon whom the counterfeiters have preyed–with fatal results.. Title: Familial Barrett's esophagus associated with adenocarcinoma.
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eng_Latn
| 32,083 |
alerian mlp stock
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About Alerian MLP (AMLP) ALERIAN MLP ETF seeks investment results that correspond (before fees and expenses) to the price and yield performance of its underlying index, the Alerian MLP Infrastructure Index (the Index).
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NovoLog FlexPen is a 3-ml prefilled syringe that contains insulin aspart [rDNA origin] (100 units/ml). NovoLog Mix 70/30 FlexPen is a prefilled syringe that contains 3 ml of a mixture of 70% insulin aspart protamine crystals and 30% soluble insulin aspart (rDNA origin). FlexPen syringes that are not currently in use should be stored under refrigeration (36â46°F [2â8°C]), but not in the freezer compartment.
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eng_Latn
| 32,084 |
what is isosorb
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Isosorbide is a heterocyclic compound that is derived from glucose. Isosorbide and its two isomers, namely isoidide and isomannide, are 1,4:3,6-dianhydrohexitols. It is a white solid that is prepared from the double dehydration of sorbitol. Isosorbide is a non-toxic diol produced from biobased feedstocks, that is biodegradable and thermally stable.
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Isosorbide dinitrate is the generic name of a drug that is also sold under the brand names Isordil, Isordil Titradose, Dilatrate-SR, and Sorbitrate. It's also an active ingredient in the prescription drug BiDil. Doctors prescribe isosorbide to prevent and treat frequent chest pain due to lack of oxygen to the heart (chronic angina) caused by coronary heart disease, and to treat congestive heart failure. Isosorbide belongs to a class of drugs known as nitrates.
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eng_Latn
| 32,085 |
what is the active ingredient in lysol
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The active ingredient in most Lysol products is benzalkonium chloride, which primarily functions as a disinfectant. Lysol was first introduced in Germany in 1889 to end a cholera epidemic.
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In the case of Vyvanse (lisdexamfetamine dimesylate), once it is absorbed by the body, an amino acid (l-lysine) is cleaved off the molecule in the liver, leaving dextroamphetamine, the active ingredient. The maximum concentration in the blood (Tmax) is reached in about 3.5 hours.
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eng_Latn
| 32,086 |
is isosorbide mononitrate a diuretic
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Be the first to review this Drug. Isosorbide mononitrate is in a group of drugs called nitrates. Isosorbide mononitrate dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump. Isosorbide mononitrate is used to prevent angina attacks (chest pain).
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Isosorbide is a heterocyclic compound that is derived from glucose. Isosorbide and its two isomers, namely isoidide and isomannide, are 1,4:3,6-dianhydrohexitols. It is a white solid that is prepared from the double dehydration of sorbitol. Isosorbide is a non-toxic diol produced from biobased feedstocks, that is biodegradable and thermally stable.
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eng_Latn
| 32,087 |
is digoxin the same as digitek
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DRUG DESCRIPTION. DIGITEK (digoxin) is one of the cardiac (or digitalis) glycosides, a closely related group of drugs having in common specific effects on the myocardium. These drugs are found in a number of plants.Digoxin is extracted from the leaves of Digitalis lanata.IGITEK (digoxin) is one of the cardiac (or digitalis) glycosides, a closely related group of drugs having in common specific effects on the myocardium. These drugs are found in a number of plants.
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Digoxin is a purified cardiac glycoside similar to digitoxin extracted from the foxglove plant, Digitalis lanata. Digoxin is occasionally used in the treatment of various heart conditions, namely atrial fibrillation, atrial flutter and sometimes heart failure that cannot be controlled by other medication.There are concerns that its general use may increase the risk of death.igoxin is occasionally used in the treatment of various heart conditions, namely atrial fibrillation, atrial flutter and sometimes heart failure that cannot be controlled by other medication. There are concerns that its general use may increase the risk of death.
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eng_Latn
| 32,088 |
what is kagan structures?
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Co-op Co-op (Kagan 1985a) is. a 10-step structure in which students in. teams produce a project that fosters the. learning of students in other teams. Each student has his or her mini-topic, and each team makes a distinct contri. bution toward the class goal. The struc.
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HYALGAN is a sterile mixture that is made up mostly of a natural, highly purified sodium hyaluronate that comes from rooster combs. Hyaluronate is a natural chemical found in the body and it is present in a particularly high amount in joint tissues and in the fluid that fills the joins.ne group was given an injection of HYALGAN into one knee joint once a week for 5 weeks. The second group was given an injection of salt water into one knee joint once a week for 5 weeks. The third group received two naproxen tablets every day for 6 months.
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eng_Latn
| 32,089 |
allan paivio psychology definition
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But although cognitive psychology is concerned with all human activity rather than some fraction of it, the concern is from a particular point of view. Other viewpoints are equally legitimate and necessary. Dynamic psychology, which begins with motives rather than with sensory input, is a case in point.
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Allantoin is considered to be nontoxic, nonirritating and non-allergenic. Allantoin is safe and effective in the dosage range recommended (0.5 to 2.0%) as a skin protectant. Allantoin is a unique product that is used for skin protection.Allantoin is a white, odorless, crystalline powder. Allantoin is also used to hasten the growth of new, healthy tissue.llantoin is a unique product that is used for skin protection. Allantoin is a white, odorless, crystalline powder.
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eng_Latn
| 32,090 |
what are the ingredients in trintellix
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The clinical safety of Trintellix (active ingredient vortioxetine) was based on data collected from MDD clinical studies which included more than 6,700 adult patients, of whom 3,460 were treated with Trintellix (5 to 20 mg/day) in short-term placebo-controlled studies of up to 8 weeks in duration.
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The structural formula is: Vortioxetine HBr is a white to very slightly beige powder that is slightly soluble in water. Each TRINTELLIX tablet contains 6.355 mg, 12.71 mg or 25.42 mg of vortioxetine HBr equivalent to 5 mg, 10 mg, or 20 mg of vortioxetine, respectively.
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eng_Latn
| 32,091 |
types of vials for medications
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Modern vials are often made out of plastic or sometimes glass. There are often used as storage for small quantities of liquid used in medical or molecular biology applications. There are several different types of commonly used closure systems. For glass vials, options include screw vials (closed with a screw cap or dropper/pipette), lip vials (closed with a cork or plastic stopper) and crimp vials (closed with a rubber stopper and a metal cap).
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Each vial, which will bind approximately 0.5 mg of digoxin (or digitoxin), contains 38 mg of digoxin-specific Fab fragments derived from sheep plus 75 mg of sorbitol as a stabilizer and 28 mg of sodium chloride. The vial contains no preservatives.
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eng_Latn
| 32,092 |
what is silexan
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Silexan is a new, German-developed lavender oil supplement formula that has proved very effective in the treatment of anxiety disorders. It has been clinically proven to have a good anxiolytic effect and is useful for those suffering from anxiety-related disturbed sleep.
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Siladium is a trademark for a stainless steel alloy used in jewelry, particularly in high school and college class rings. The trademark was registered in 1973 to John Roberts, Inc., maker of the Artcarved brand of class rings. John Roberts, Inc., and the Siladium trademark were subsequently acquired by CRC Holdings, Inc., of Austin, Texas.
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eng_Latn
| 32,093 |
where is lsd most commonly found
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LSD is usually found on âblotterâ paper (paper that is perforated into small squares). The squares or âtabsâ may be colored or have images printed on them. Liquid LSD is a clear liquid, usually in a small container, tube or flask. LSD can also be found in thin squares of gelatin.ome LSD users experience flashbacks, recurrence of certain aspects of a personâs experience even if the user doesnât take the drug again. A flashback occurs suddenly, often without warning, and may occur within a few days or more than a year after LSD use.
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Lysergic acid diethylamide, known as LSD, is one of the most powerful hallucinogens out there. It is a drug of extreme unpredictability, and is banned for use in the United States, even though it was once used as a psychiatric drug, and has been used in secret government tests.he scientist that made it did so using ergot. Ergot is a fungus that grows on grains, especially rye. The LSD was synthesized and then self-tested. Originally, it was thought that the drug could be used to help with circulation.
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eng_Latn
| 32,094 |
what kind of drops make up bimatoprost?
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Careprost Eye Drops in strength of 0.03% of Bimatoprost, manufactured by Sun Pharmaceutical Industries Ltd., India is supplied in a bottle of 3 ml eye drops. The 3 ml bottle cost only $16.49 per unit when you place an order for 10 bottles.
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Bimatoprost is a powder, which is very soluble in ethyl alcohol and methyl alcohol and slightly soluble in water. LUMIGAN® 0.03% is a clear, isotonic, colorless, sterile ophthalmic solution with an osmolality of approximately 290 mOsmol/kg. LUMIGAN® 0.03% contains Active: bimatoprost 0.3 mg/mL; Inactives: benzalkonium chloride 0.05 mg/mL; sodium
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eng_Latn
| 32,095 |
what color is cephalexin 500mg
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Cephalexin 250mg Tablet. This medicine is a white, oblong, scored tablet imprinted with BL 136, TEVA, 9 3, and 2238 and is manufactured by Teva Pharmaceuticals USA Inc.ephalexin Images. This medicine is a white, oblong, scored tablet imprinted with BL 136, TEVA, 9 3, and 2238 and is manufactured by Teva Pharmaceuticals USA Inc.
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UKPAR Cefalexin 250 and 500 mg Capsules PL 35507/0104-5 4 INTRODUCTION Based on the review of the data on quality, safety and efficacy, the MHRA granted Lupin (Europe) Limited Marketing Authorisations for the medicinal products Cefalexin 250 mg and 500 mg Capsules (PL 20092/0064-5) on 15 th July 2011.KPAR Cefalexin 250 and 500 mg Capsules PL 35507/0104-5 8 In-process controls have been provided and are appropriate considering the nature of the products and the method of manufacture. Process validation studies were conducted and the results were satisfactory.
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eng_Latn
| 32,096 |
definition of cocamidopropyl betaine
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Cocamidopropyl betaine (CAPB) is an organic compound derived from coconut oil and dimethylaminopropylamine.It is a zwitterion, consisting of both a quaternary ammonium cation and a carboxylate. CAPB is available as viscous pale yellow solution that is used as a surfactant in personal care products.The name reflects that the major part of the molecule, the lauric acid group, is derived from coconut oil.APB is available as viscous pale yellow solution that is used as a surfactant in personal care products. The name reflects that the major part of the molecule, the lauric acid group, is derived from coconut oil.
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Betaine -- also called betaine anhydrous, or trimethylglycine (TMG) -- is a substance that's made in the body. It's involved in liver function, cellular reproduction, and helping make carnitine. It also helps the body metabolize an amino acid called homocysteine. The US Food and Drug Administration (FDA) approved betaine to treat a genetic condition where too much homocysteine builds up in the body.
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eng_Latn
| 32,097 |
what is lsd made of
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LSD (lysergic acid diethylamide) is one of the major drugs making up the hallucinogen class. LSD was discovered in 1938 and is one of the most potent mood-changing chemicals. It is manufactured from lysergic acid, which is found in ergot, a fungus that grows on rye and other grains.
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LSD was first made in 1938. The scientist that made it did so using ergot. Ergot is a fungus that grows on grains, especially rye. The LSD was synthesized and then self-tested. Originally, it was thought that the drug could be used to help with circulation.
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eng_Latn
| 32,098 |
when did lsd come out
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The psychedelic drug (or entheogen) lysergic acid diethylamide (LSD) was first synthesized on November 16, 1938 by the Swiss chemist Albert Hofmann in the Sandoz (now Novartis) laboratories in Basel, Switzerland. It was not until five years later on April 19, 1943, that the psychedelic properties were found.
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In 1938, a Swiss chemist named Albert Hofmann synthesized LSD for the first time while studying ergots, a type of fungus. Though the pharmaceutical company that he worked for, Sandoz, didn't have any interest in the compound, Hofmann found himself inexplicably drawn to it.
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eng_Latn
| 32,099 |
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