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what is rooster comb made of
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Hyaluronic Acid - Rooster Juice. Hyaluronic Acid is a natural substance found in all living organisms other than plants. Your own body makes it and it's found in your joints, eyeballs and skin. When isolated, it's a very thick, viscous liquid. It works as a lubricant and shock absorber in the knee, and more importantly, it's a natural pain inhibitor. Most Hyaluronic Acid for Joint Fluid Therapy is made from the combs of roosters. One of our patients referred to it as Rooster Juice, and that's been our nickname for it ever since. (So if you do an Internet search for more information, use the term Hyaluronic Acid, as the keyword Rooster Juice will get you nowhere!). There are several brands of Hyaluronic Acid.
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WHAT IS IT? Hyaluronic acid, also known as viscosupplementation injection or rooster comb injection, is used for the treatment of knee, hip, shoulder, elbow and ankle osteoarthritis. Currently it is only FDA/insurance approved for the knee, although studies are currently been performed on all other joints.
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eng_Latn
| 32,100 |
what is synthol
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Synthol is a sterile neutral oil that is locally injected right into the muscle. It becomes encapsulated in the bundles of muscle fibers which adds extreme volume to the muscl ⦠e.The term Synthol used to describe any Site Enhancement Oil (SEO). Steroids are hormones.Source: Syntholmuscle.com.ynthol is a sterile neutral oil that is locally injected right into the muscle. It becomes encapsulated in the bundles of muscle fibers which adds extreme volume to the muscl ⦠e. The term Synthol used to describe any Site Enhancement Oil (SEO). Steroids are hormones. Source: Syntholmuscle.com.
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Synthol is a site enhancement oil (SEO) meant to create the illusion of a developed muscle. Due to its cosmetics properties the substance is used heavily in bodybuilding, fitness and modeling.Bodybuilders rely on synthol to hide a lagging body part which may not be responding well to training.ynthol is often infected in the muscles of the lower leg (calves), the visible shoulder muscle (deltoids) and the muscles of the upper arms (biceps and triceps). The use of oil to cover a weakness is commonly referred to as âfluffingâ.
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eng_Latn
| 32,101 |
how is albumin manufactured
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ALBUMIN (HUMAN) 25% SOLUTION, USP is made from pooled human venous plasma. using the Cohn cold ethanol fractionation process. It is prepared in accordance with the. applicable requirements established by the U.S. Food and Drug Administration.
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L-valine is manufactured by fermentation from carbohydrate sources. No materials of animal origin are used in the production of L-valine. Ajinomoto manufactures L-valine under cGMP conditions, and a Drug Master File is on record at the FDA. L-valine meets USP, EP and JP specifications.
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eng_Latn
| 32,102 |
what is cyclomethicone
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Cyclomethicone is a general term describing both individual and/or a mixture of cyclic siloxane materials that have many uses and are found in a variety of consumer products. These materials are derived from the natural elements silicon and oxygen.
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Perfluorononyl dimethicone/ methicone/amodimethicone crosspolymer Perfluorononyl dimethicone/methicone/amodimethicone crosspolymer is a crosslinked silicone polymer that is formed by reacting a copolymer of perfluoronony l dimethicone and methicone with methicone and amodimethicone.
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eng_Latn
| 32,103 |
what is alimta
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What is pemetrexed (Alimta)? Pemetrexed is a cancer medication that interferes with the growth and spread of cancer cells in the body. Pemetrexed is used to treat non-small cell lung cancer after other cancer medications have been tried without successful treatment. Pemetrexed is also used with another medication called cisplatin (Platinol) to treat mesothelioma, a form of lung cancer associated with exposure to asbestos.
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Embrace the power of 5: this number symbolizes balance, intuition and energetic motion. âLimaâ is also the Balinese word for 5. In a village at the edge of a jungle in Bali, each bracelet is hand carved from natural water buffalo bone and woven into an adjustable nylon thread band. Maximum length: 8 inches for tassel style and 7.5 inches for button style.
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eng_Latn
| 32,104 |
what is alendronic acid
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Alendronic acid (INN) or alendronate sodium (USAN) â sold as Fosamax by Merck â is a bisphosphonate drug used for osteoporosis and several other bone diseases.It is marketed alone as well as in combination with vitamin D (2,800 IU and 5,600 IU, under the name Fosamax+D).Merck's U.S. patent on alendronate expired in 2008 and the drug is now available as a generic.t is marketed alone as well as in combination with vitamin D (2,800 IU and 5,600 IU, under the name Fosamax+D). Merck's U.S. patent on alendronate expired in 2008 and the drug is now available as a generic.
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Alendronate is also available in combination with cholecalciferol (vitamin D3). The combination alendronate/vitamin D3 (Fosamax Plus D) is indicated for the treatment of osteoporosis in men to increase bone mass.
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eng_Latn
| 32,105 |
diltiazem maximum dose
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Diltiazem hydrochloride is a white to off-white crystalline powder with a bitter taste. It is soluble in water, methanol and chloroform. It has a molecular weight of 450.99. CARDIZEM LA is formulated as a once-a-day extended-release tablet for oral administration containing 120 mg, 180 mg, 240 mg, 300 mg, 360 mg or 420 mg of diltiazem hydrochloride.
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Diltiazem products on the Saskatchewan Drug Plan formulary1. Diltiazem CD capsule 120 mg, 180 mg, 240 mg, 300 mg. Reference product = Cardizem CD, various generics (often denoted as diltiazem CD) Release mechanism: encapsulated beads2. Diltiazem ER capsule 120 mg, 180 mg, 240 mg, 300 mg, 360 mg. Reference product = Tiazac, various generics (often denoted as diltiazem T) Release mechanism: âdrug-pasteâ is converted into small immediate release beads, which are then. coated with a rate-controlling polymer.3.
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por_Latn
| 32,106 |
what is yohimbine
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Yohimbine is an active chemical (an alkaloid) found in said bark and is cultivated into supplement form. Yohimbine hydrochloride is a standardized form of yohimbine that is available as a prescription drug in the United States.
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Yohimbe (Pausinystalia johimbe) is a tree that grows in western and central Africa; yohimbine was originally extracted from the bark of yohimbe in 1896 by Adolph Spiegel.In 1943 the correct constitution of yohimbine was proposed by Witkop.ohimbine is a drug used in veterinary medicine to reverse the effects of xylazine in dogs and deer. Yohimbe extracts, which contain yohimbine, have been used in traditional medicine in West Africa as an aphrodisiac and yohimbe extracts have been marketed as dietary supplements.
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eng_Latn
| 32,107 |
weixin windows
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The original version of the app, Weixin, was invented by Xiaolong Zhang, and named by Ma Huateng, Tencent CEO and was first launched in 2011. The government has actively supported the development of the e-commerce market in China - for example in the 12th five-year plan (2011-2015). By 2012, the number of users reached 100 million and Weixin was re-branded as WeChat for the international market.
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Pramoxine is used to temporarily relieve pain and itching from insect bites; poison ivy, poison oak, or poison sumac; minor cuts ... severe itching; difficulty breathing or swallowing; swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs; hoarseness.
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cat_Latn
| 32,108 |
what is pentaerythrityl tetraethylhexanoate
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About PENTAERYTHRITYL TETRAISOSTEARATE: Pentaerythrityl tetraisostearate is a synthetic lipid-based ingredient used as a skin conditioning agent. Function(s): Binder; Skin-Conditioning Agent - Occlusive; Viscosity Increasing Agent - Nonaqueous; EMOLLIENT; EMULSIFYING; SURFACTANT.
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Pentaerythritol tetranitrate. Pentaerythritol tetranitrate (PETN), also known as PENT, PENTA, TEN, corpent, penthrite (orârarely and primarily in Germanâas nitropenta), is the nitrate ester of pentaerythritol, and is structurally very similar to nitroglycerin. Penta refers to the five carbon atoms of the neopentane skeleton.
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eng_Latn
| 32,109 |
what is htc ?
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HTC Reference. For Microsoft Internet Explorer 5 and later, HTML Components (HTCs) provide a mechanism to implement components in script as Dynamic HTML (DHTML) behaviors. An HTC is an HTML file that contains script and a set of HTC-specific elements that define the component. The component is saved with an .htc extension.
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For other uses, see HPMC (disambiguation) . Hypromellose (INN), short for hydroxypropyl methylcellulose (HPMC), is a semisynthetic, inert, viscoelastic polymer used as an ophthalmic lubricant, as well as an excipient and controlled-delivery component in oral medicaments, found in a variety of commercial products.ypromellose is a solid, and is a slightly off-white to beige powder in appearance and may be formed into granules. The compound forms colloids when dissolved in water. This non-toxic ingredient is combustible and can react vigorously with oxidising agents.
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eng_Latn
| 32,110 |
what is lk
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.lk is the Internet country code top-level domain (ccTLD) for Sri Lanka. Foreign companies who do not have a local presence can only reserve their top-level and corresponding open second-level domains (either through the LK Domain Registry or agents). In order to register and use a name they must have a contact address in Sri Lanka (which may be obtained through an agent or law firm).
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L-lysine, also called lysine or amino acid K, is an essential amino acid that is important for proper growth of the body.-Lysine, or lysine, is an important essential amino acid needed by the human body for tissue repair and growth.
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eng_Latn
| 32,111 |
what is the difference between tartate and succinate
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Tartrate vs Succinate. The key difference between tartrate and succinate is that succinate is derived from the succinic acid and tartrate is derived from the tartaric acid. These two chemical substances are widely used in the beverage industry and drug manufacturing.Succinic acid is ethan-1,2-dicarboxylic acid. Succinate form of metoprolol is an extended release drug and it plays its role in the circulatory system for 24 hours. However, the tartrate form of metoprolol does not appear in the blood stream for 24 hours because metoprolol tartrate is an immediate-release drug.
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Succinate dehydrogenase catalyzes the conversion of succinate to fumarate. The reaction is inhibited by malonic acid, which resembles succinate but cannot be acted upon by succinate dehydrogenase. Increasing the ratio of succinate to malonic acid reduces the inhibitory effect of malonic acid.
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eng_Latn
| 32,112 |
pcp is what type of drug
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Phencyclidine (PCP) Profile Phencyclidine (PCP) is a synthetic dissociative drug originally developed as a general anesthetic. The effects of dissociative drugs like PCP include feelings of detatchment from the environment and self.In its pure form, PCP is a white crystalline powder that dissolves easily in water or alcohol. As a liquid, it is clear, yellow, or tan and often is sold in vanilla extract bottles.he effects of dissociative drugs like PCP include feelings of detatchment from the environment and self. In its pure form, PCP is a white crystalline powder that dissolves easily in water or alcohol. As a liquid, it is clear, yellow, or tan and often is sold in vanilla extract bottles.
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Phencyclidine, or PCP, is a dissociative anesthetic. PCP has both hallucinogen and stimulant effects. Effects include feelings of sedation, euphoria, calmness, feelings of bei ⦠ng out of body, illusions and hallucinations, distorted sensory perceptions, and agitation.
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eng_Latn
| 32,113 |
These co-reactants are often referred to as hardeners or curatives , and the cross-linking reaction is commonly referred to as curing .
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Their co-reactants are often called ` hardeners ' or ` curatives ' , and the cross-linking reaction is referred to as ` curing ' .
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Heal 's ( `` Heal and Sons Ltd '' ) is a British department store furniture and furnishing store chain with six stores . The stores sell an upmarket range of furniture , lighting , accessories , home and garden-wares .
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eng_Latn
| 32,114 |
Is this SafeStart or SafeStart+? Description says "SafeStart", but pictures of 100ml & 250ml are "SafeStart+" bottles. SafeStart dose is 50ml/15g, SafeStart+ is 5ml/10g; that is 30g vs 200g for 100ml bottle Is this SafeStart or SafeStart+? Description says "SafeStart", but pictures of 100ml & 250ml are "SafeStart+" bottles. SafeStart dose is 50ml/15g, SafeStart+ is 5ml/10g;... » Read More Is this SafeStart or SafeStart+? Description says "SafeStart", but pictures of 100ml & 250ml are "SafeStart+" bottles. SafeStart dose is 50ml/15g, SafeStart+ is 5ml/10g; that is 30g vs 200g for 100ml bottle « Show Less
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It is safe start plus. Tetra is no longer making regular safe start. I have bought this before.
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I am not sure about others but I could notice the differences. I purchased both sponges since I couldn't decide at that time. Size wise, this sponge is more practical and easier for me to hold because it is much bigger than puresol. Color wise, puresol sponge is very black and when I first soaked it, the water turned black, which made me believe some kind of chemical coloring must have been added. Then I looked at the box and it says that puresol brand is made in China. Since there are many questionable Chinese products in the market, I decided I didn't want to use it on my skin. So far I have used this my konjac brand for the past few months and my skin has never looked better. Love it! I am not sure about others but I could notice the differences. I purchased both sponges since I couldn't decide at that time. Size wise, this sponge is more practical and easier for me to hold because it is much bigger than puresol. Color wise, puresol sponge is very black and when I first soaked it, the water turned black, which made me believe some kind of chemical coloring must have been added. Then I looked at the box and it says that puresol brand is made in China. Since there are many questionable Chinese products in the market, I decided I didn't want to use it on my skin. So far I... » Read More I am not sure about others but I could notice the differences. I purchased both sponges since I couldn't decide at that time. Size wise, this sponge is more practical and easier for me to hold because it is much bigger than puresol. Color wise, puresol sponge is very black and when I first soaked it, the water turned black, which made me believe some kind of chemical coloring must have been added. Then I looked at the box and it says that puresol brand is made in China. Since there are many questionable Chinese products in the market, I decided I didn't want to use it on my skin. So far I have used this my konjac brand for the past few months and my skin has never looked better. Love it! « Show Less
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eng_Latn
| 32,115 |
I see the purity is 99.9%, but would like to know the Concentration( dilution with water) Thank you.
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This is not diluted. This brand, tree of life, does sell a diluted version and they clearly state dilution so always check the label/info. Distilled water is recommended to use for dilution. Generally you want to dilute, but why ship distilled water?
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The ingredient in both appears to be the same. The Vision Clarity drops specify that the ingredient is N-acetyl-carnosine. An "L" in the ingredient name would indicate that it is a left-handed molecule. Many organic compounds have both an R and an L configuration. Typically, only one of the configurations is produced as a naturally occurring compound. When both configurations are present, it generally signifies that the compound has been synthesized in a process that produces both configurations.
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eng_Latn
| 32,116 |
will this kill kudzu? wisteria?
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A systemic herbicide, for example, glyphosate,[40] Triclopyr,[40] or Tordon,[41] can be applied directly on cut stems, which is an effective means of transporting the herbicide into the kudzu's extensive root system
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Many plastics are damaged by xylene and acetone...these may be present in some cleaners. I often use WD-40 to clean sticky residues.
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eng_Latn
| 32,117 |
Would this be considered 1% or 2% ketoconazole shampoo?
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That's a good question. The bottle doesn't say anything about strength, however conventionally most keto-containing shampoos are 2% nowadays. Even the nizoral 1% is hardly found in the pharmacies these days so I think 2% is a safe assumption.
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my container says manufactured for Bayer.....Shawnee Mission, KS 1-800-255-6826 www.bayerdvm.com and has a quality seal "nasc"=> national animal supplement council
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eng_Latn
| 32,118 |
What is the difference between model #B00BB0ZYIQ to this one BPRO364, both by Beauty Pro?..
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I am not sure but I have BP0912US and I love it. They could be different batch numbers of the same product. I really love the product so just order one and see if you like it. If you don't like it return it. I think you will find you will love it, good luck to you.
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Hi, the bottle does not show the ingredients. I called the 800-537-1063 (BSN MEdical) number on the bottle and the girl said since the ingredients are a "trade secret" they cannot tell me. I asked if she could at least tell me if it is water based or Silicone, she said it (I am guessing computer) would not tell her. She did confirm that it is Latex Free. I can tell from the smell there is alcohol, smells like isopropyl alcohol. I could not find the item on the website, but here you go. http://www.jobst-usa.com/. Sorry I was not more help.
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eng_Latn
| 32,119 |
What's the difference between this & Lugol's Solution 5%?
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This is 'nascent' iodine- it is a different form from Lugol's. This is much gentler on the stomach and much more absorbable. I highly recommend this over Lugol's, which I tried first with less success.
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No it cannot, unless you want to pry it open, or razor off the top portion of the plastic bottle and put it in something else. Its alot of money for so little. let us know if diluting it works. I'm running low and have been watching the price on amazon and online elseware for the lowest cost the last time I bought it on amazon it was 46.33 for 3 bottles, it was a long time ago though almost 2 years. I only use it when one of the cats does something they shouldnt so it did last long, but just cant use it often or you'll be buying alot of it.
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eng_Latn
| 32,120 |
Generic name for synthetic soap substitutes
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Detergent - Wikipedia For other uses, see Detergent (disambiguation). Detergents. A detergent is a surfactant or a mixture of surfactants with "cleaning properties in dilute ... Synthetic detergents were first made in Germany. ... phosphates in detergents. Manufacturers are using substitutes such as EDTA and other biodegradable chemicals instead.
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J! Archive - Show #2808, aired 1996-11-13 My bologna's first name ... In 1996 this former "Dynasty" star published a Hollywood sizzler called "Infamous" ... Chopped coriander leaves popular in salsas are also known by this Spanish name...
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eng_Latn
| 32,121 |
The Schlosser base ( or Lochmann-Schlosser base ) , the combination of n-butyllithium and potassium tert-butoxide , is a commonly used superbase .
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In organic synthesis , the Schlosser base ( or Lochmann-Schlosser base ) , the combination of n-butyllithium and potassium tert-butoxide , is a commonly used superbase .
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Louise Élisabeth de Bourbon ( Louise Élisabeth ; 22 November 1693 -- 27 May 1775 ) was a daughter of Louis de Bourbon , Prince of Condé , and his wife , Louise Françoise de Bourbon , herself an illegitimate daughter of Louis XIV of France and Madame de Montespan .
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eng_Latn
| 32,122 |
Dependence of pharmacokinetic properties of 1,4-dihydropyridine calcium antagonists on agglomeration in crystals
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With the aim of validating the hypothesis that the pharmacokinetic properties of drugs depend on molecular agglomeration, crystal-chemical analysis was performed for the following representatives of 1,4-dihydropyridine calcium antagonists: nifedipine, felodipine, and nitrendipine. These compounds belong to the structural class P21/c, Z = 4(1). The energy of intermolecular interactions was calculated with the use of the CCA program designed for the conventional crystal-chemical analysis. The structural subclasses for the compounds in question were determined. On the basis of the published data, the relationship between the pharmacokinetic properties of these compounds and molecular agglomeration was revealed.
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Object of the present invention to provide a granular preparation hours even in average particle diameter, can be effectively controlled drug dissolution characteristics. The present invention provides a granule formulation, wherein that the first coating layer containing a water-insoluble polymer particles and inorganic particles and granular formulations of a drug having a first cladding layer of the coated drug particles and / or lipid components, the lipid component contains more C15 fatty acids.
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eng_Latn
| 32,123 |
CONVERSION OF A 4-QUINOLONE INTO A 1,6-DIAZAPHENALENE
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Abstract 5,8-Dimethoxyquinolin-4-one has been transformed in five steps into a 7-oxo-1,6-diazaphenalene and in 4 steps into 6-aza-1-oxaphenalene.
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Objective To optimize the extraction technology of Yanqing Granule by orthogonal test.Methods Using the contents of chlorogenic acid and total extraction as indexes,choosing solvent volume,extracting duration and extracting times as influential factors,the optimal extraction condition was studied by L9(34) orthogonal test.Results The optimal extraction condition of Yanqing Granule was: 200 mL water for 1/3 amount of drugs,refluxing extraction for 3 times and 0.5 h each time.Conclusion The optimal extraction technology obtained in this study is simple and reproducible,and it has a higher application value in the production of Yanqing Granule.
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yue_Hant
| 32,124 |
Composite capsule for stomach intestine and its preparing method and use
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The present invention relates to medicine and its production process, and the composite gastrointestinal capsule is one kind of oral medicine preparation with both stomach releasing medicine component and intestine releasing medicine component. The composite gastrointestinal capsule includes one capsule cap capable of being dissolved inside stomach and holding stomach releasing medicine component, and one capsule body cap capable of being dissolved inside intestine and holding intestine releasing medicine component. The medicine preparation features no mutual action between different medicine components, raised compound medicine preparation stability, located medicine releasing, reduced stimulation on stomach and intestine of some medicine, synergistic medicine action and accurate medicine content.
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In the paper,a comprehensive analysis was conducted on design,construction and testing of the immersed tube rammed pile of concrete and soil compaction pile of double compound foundation treatment in the collapsible region through the projects example,and it was analysized that the effect and the existing problems of the mixed foundation treatment in the collapsible region.
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eng_Latn
| 32,125 |
Thienospirans VI: Spiro-substituted Thieno[3,2-c]furans by Regioselective Lithiations
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A partir de la double lithiation-addition du dibromo-3,4 thiophene, via la cyclodeshydratation de diols ou d'hydroxyacides, synthese de spiro [cyclohexane-1:- et piperidine-4:1'-thieno [3,4-c] furannes]
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Objective: To design a new synthetic technology of the anti-malarial drug lumefantrine.Methods: Industrial fluorine was used as starting material.In the presence of manganese dioxide and using glacial acetic acid as solvent,inletting hydrogen chloride gas and 2,7-dichlorofluorene were produced.Then,using anhydrous AlCl3 as catalyst,2,7-dichlorofluorene reacted with chloracetyl chloride to produce 2,7-dichloro-4-chloracetyl fluorene.Finally,the "one-pot reaction" was used for the reduction,amination and condensation reaction to obtain lumefantrine.Results and Conclusion: The total yield of this technology was over 40% based on fluorene,its processing steps were less than those of previous technologies,and the operation was simple.Thus,the new method is much more advanced and the new process route is much more suitable for industrial production.
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eng_Latn
| 32,126 |
Vulcanization of butyl rubber by p‐quinone dioxime
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Abstract The vulcanization of butyl rubber by p-quinone dioxime oxidized by red lead and tetrachloroquinone was investigated. The maximum physical effective crosslinking density of the vulcanizates appeared to be when p-quinone dioxime and the oxidizing agent were equimolar. The formation of one physical effective crosslink required one molecule of p-quinone dioxime. Chemical reactions are suggested for the vulcanization steps.
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Shun-chun-ping capsule composed of dyphylline, clenbuterol,anisoda-mine, decloxizine, bisolvon etc. and used for the treatment of bronchial asthma 20 cases, gave a promising result with sulbutamol, a sole agent, served as reference and tested according to double blind, cross-over method. With 10 items of pulmonary functions including FEV1, clinical symptoms and signs as judgments the therapeutic value of this capsule is definitely superior than salbutamol given alone. In addition, the duration of action of this capsule could be last more than 8 hrs.
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eng_Latn
| 32,127 |
Different Dissolution Media Lead to Different Crystal Structures of Talinolol with Impact on Its Dissolution and Solubility
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AbstractDuring the performance of dissolution tests with immediate and controlled-release talinolol tablets it was detected that the type of the buffer used as dissolution medium had a strong influence on the solubility and the dissolution behavior of the drug. It was proven that talinolol appeared in different crystal structures with strongly differing solubilities when pure water, acetate, or phosphate buffers were employed as dissolution media. The resulting crystal structures were characterized by means of light microscopy, differential scanning calorimetry, and X-ray powder diffraction. All methods were adjuvant to detect changes in talinolol crystal structures. The different solubility and dissolution properties of the talinolol salts or modifications may be viewed as a source for its incomplete and variable bioavailability. Furthermore, the food effect, described in the literature, that leads to a decrease in talinolol absorption, could be due to changes in the composition of gastrointestinal fluid...
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Objective:To prepare total matrine controlled release micropellet capsules.Methods:The capsules were prepared by the technology of film-coating with surelease as matrix,and judged by the release behavior.Results:The drug had completely been coated into a homogeneous and continuous film,and the results repeated in three batches showed that the release behavior of the pellet capsules followed zero-equation.Conclusion:The capsules have good sustained release effect and the process of the preparation is available.
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eng_Latn
| 32,128 |
[Unusual form of esophagobronchial fistula in adults].
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We describe the case of an adult patient with a benign congenital esophagobronchial fistula. The different types of congenital fistula without atresia or in H form are discussed. We formulate some hypotheses explaining the late occurrence of symptoms in a lesion present since the patient's birth.
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Abstract Two methods for calculating activity coefficients of ultra-low sulfur diesel (ULSD) and its blends with pure alcohols (C1–C5), namely, UNIFAC-continuous and UNIFAC-Dortmund-continuous, are presented. ULSD was modeled as a continuous blend of paraffins, naphthenes, and aromatics. The molar distribution in each family was expressed as a function of carbon number using the gamma distribution function. The parameters of the distribution function can be easily fitted from experimental distillation data of ULSD and extrapolated to n-alcohol/ULSD blends. The activity coefficients obtained were used to model the ASTM D86 distillation curves. UNIFAC-Dortmund-continuous exhibited the best fitting to the experimental results. Based on that, three new correlations for calculating the boiling point, vapor pressure and structural groups of complex ULSD are proposed here.
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eng_Latn
| 32,129 |
Shoot Regeneration and Polyacetylene Production in Root Cultures of Lobelia Erinus
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Adventitious shoots of Lobelia erinus (Campanulaceae) were directly regenerated from the root tissues cultured in hormone-free Murashige-Skoog (MS) medium under lighted conditions. The regenerants proliferated well both in vitro (in hormone-free MS solid medium) and in vivo (in soil in a pot). The final survival frequency of the transplanted regenerants in soil was 90 %. There were no morphological differences between the regenerants and the parental plants. The polyacetylene (lobetyol, lobetyolin and lobetyolinin) content of the regenerants in vitro was identical to that obtained from shoot cultures regenerated from the callus cultures. The polyacetylene content of the regenerants cultivated in a pot was also identical with the field-grown parental plants. Direct shoot regeneration from L. erinus root tissues provides a good culture system for the micropropagation of this important medicinal herb.
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Organic materials for optical data storage applications is a fascinating and growing field of research [1]. Of special interest are liquid-crystalline polymers (LCPs), especially side chain polymers [2]. They have been proposed as optical recording media by many authors [3–6].
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eng_Latn
| 32,130 |
Inhibition Effect of Azadirachta indica, a Natural Product, on the Corrosion of Zinc in Hydrochloric Acid Solution
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The corrosion behavior of zinc in 0.2 M hydrochloric acid solution by Azadirachta indica (AI-Neem) was investigated using mass loss, electrochemical polarization and impedance methods. Inhibition efficiency depends on the concentration of AI-Neem and it reaches maximum value at 1,000 ppm. The shape of polarization profile indicated that AI-Neem is a mixed type inhibitor with predominant cathodic effect. Adsorption of AI-Neem on the zinc surface follows Temkin adsorption isotherm. The surface morphology of zinc was studied by using scanning electron microscope images.
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OBJECTIVE: To establish HPLC fingerprint of Compound danshen tablets.METHODS: The separation was performed on Agilent Eclipse XDB-C18(150 mm×4.6 mm,5μm) column with mobile phase consisted of acetonitrile-0.04% phosphate (gradient elution) at flow rate of 1.0 mL·min-1.Detection wavelength was set at 272 nm and column temperature was 30℃.RESULTS: Established HPLC fingerprint was distinct and reproducible.There were 8 characteristic peaks among which No.5 characteristic peaks,No.6,No.7,No.8 came from HPLC fingerprint of Salvia miltiorrhiza and No.1 characteristic peaks,No.2,No.3,No.4 came from HPLC fingerprint of Panax notoginseng.CONCLUSION: The characteristic peaks of effective parts of Compound danshen tablet mainly come from S.miltiorrhiza.The study can be used for tracing and isolation of effective part of Compound danshen tablet and establishes basis for the further development of Chinese patent drugs.
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eng_Latn
| 32,131 |
PLGA Nanoparticles for Anti Tuberculosis Drug Delivery
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Nanoparticles-based drug delivery systems have considerable potential for the treatment of tuberculosis (TB). A series of PLGA polymers with different molar feed ratios (P2:87/13, P3:83/17, P5:63/37, P6:76/24, P9:53/47) were synthesized by direct melt poly condensation method. The resulting biodegradable polymers were characterized by FTIR and 1H NMR spectroscopy. The preparation of the drug (Pyrazinamide (PZA)) encapsulated PLGA polymers were carried out by double emulsion – solvent evaporation technique. The drug loaded PLGA-NPs were analyzed by UV-visible spectroscopy and scanning electron microscopy. The drug loading efficiency and drug release kinetics varies in the following order: P9>P5>P6>P3>P2. Among the formulations, PP9 showed a uniform as well as sustained drug release. The drug release kinetics has been evaluated by Zero-order, First order, Higuchi and Koresmeyer- Peppas models and the release mechanism has also been investigated
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Objective To study the best extracting technology of Compound Taizishen Granule prescription.Methods The total polysaccharides and total saponins were determined by UV spectrophotometer.With the content of total polysaccharides and total saponins as comprehensive indexes,orthogonal test was applied to investigation of the water addition,extraction time,and extraction times for optimizing the best extracting technology.Results The best extracting technology was using 10 times the amount of water,extracting 3 times and 1.5 h per time.Conclusion The extraction technology is safe and effective,which can be used as extraction for Compound Taizishen Granule prescription.
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eng_Latn
| 32,132 |
A NEW METHOD FOR ENANTIOSELECTIVE SYNTHESIS OF β-HYDROXY-α-AMINO ACIDS
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Highly optically active threo-β-hydroxy-α-amino acids were obtained by the successive treatment of the chiral hydroxy imine 1, prepared by the condensation of t-butyl glycinate with a chiral ketol 3, with methylmagnesium iodide, potassium diisopropylamide and aldehyde.
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The invention tax injection step for injecting a minute used to dissolve detergent tax towards the laundry in the drum; Tax penetration step of waiting for a predetermined time so that the amount of a tax the ejection can be absorbed by the laundry; By spraying the laundry towards the hot steam of the steam rinse step of rinsing the laundry; And polyoxyethylene alkyl ethers (polyoxyethylene alkylether) of the minutes using detergent, comprising: a drying step of supplying hot air to the drum to dry the laundry is absorbed the steam is from 5 to 10% by weight; 3 to 5% by weight of sodium echil hexyl sulfate (sodium ethylhexyl sulfate); And to a laundry treatment process comprising the remaining amount of water.
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yue_Hant
| 32,133 |
A Facile One-Pot Synthesis of 4-Hydroxy-3-methoxycarbonyl-2-methyl-2h-1,2-benzothiazine 1,1-Dioxide, a Key Intermediate in the Synthesis of Oxicam Anti-Inflammatory Agents
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Abstract 4-Hydroxy-3-methoxycarbonyl-2-methyl-2H-1,2-benzothiazine 1,1-dioxide (8) was synthesized by a one-pot procedure, starting from the readily available saccharine. The synthesis involves 4 transformations with an overall yield equivalent to that from the stepwise process.
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The invention discloses a new process for synthetizing lythidathion. Mercaptamine and urea are used as initial materials to simply obtain lythidathion active compound of which the content is more than 98.0% by reactions of thiazolidone synthesis, sec-butyl mercaptan synthesis, sec-butyl phosphoryl chloride synthesis, lythidathion synthesis and the like.
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eng_Latn
| 32,134 |
Polyurethane plaster for the transdermal application of active ingredients and process for its preparation
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There is provided a method for producing a drug-containing polyurethane plaster for transdermal application, in which the declared dose is containing at least one active substance in high accuracy with respect to. In the method, a solvent-free active substance-containing polyurethane mixed by reactive coating of an immediately prior to or with the application process in a coating unit (60) solvent-free active substance-containing polyurethane composition (40) on an elastic carrier film (20) is generated, wherein the carrier sheet by an underlying, adherent least mono- axially inextensible auxiliary film (30) was not rendered extensible at least in the processing direction of the job.
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The present invention relates to oral formulations, and relates to a method of use, in particular oral dosage of a drug delivery system for oral contraceptives for women use. In one embodiment of the invention, the oral dosage form comprises an enteric polymer to the dispersion profile during testosterone and estrogen gen.
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eng_Latn
| 32,135 |
Water-dispersible desloratadine pill and method for its manufacture
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FIELD: pharmacology. SUBSTANCE: invention describes a pharmaceutical composition in the form of a dispersible pill comprising desloratadine and a method for its manufacture. A water-dispersible desloratadine pill is prepared by compressing the active ingredient in an amount of 2.5 or 5.0 mg with processing aids and pharmaceutically acceptable excipients and is capable of dispersing in water for 3 minutes to form a dispersion consisting of particles smaller than 710 mcm. The obtained pill possesses high stability and physical preservation, good mechanical properties in combination with fast disintegration in water solutions. EFFECT: experimentally selected composition allows for high processability of the dispersible pill manufacturing process. 2 ex, 2 tbl
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Abstract This paper concerns the properties of two ionic polysaccharides with very close chemical structures. pH metric and conductimetric measurements showed that they behave similarly from a polyelectrolytic point of view. From optical rotation and differential scanning calorimetry (DSC) measurements, the two polymers probably adopt a double helical conformation which is destabilised by deacetylation. The main differences concern the stability of this ordered conformation and the ability of these double helices to associate to form gels. The results support a higher thermal stability of the ordered conformation for deacetylated RMDP17 (about 8°C), whereas deacetylated rhamsan has a better ability to form gels.
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eng_Latn
| 32,136 |
Comparison between the physicochemical behaviour of two microbial polysaccharides: RMDP17 and rhamsan
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Abstract This paper concerns the properties of two ionic polysaccharides with very close chemical structures. pH metric and conductimetric measurements showed that they behave similarly from a polyelectrolytic point of view. From optical rotation and differential scanning calorimetry (DSC) measurements, the two polymers probably adopt a double helical conformation which is destabilised by deacetylation. The main differences concern the stability of this ordered conformation and the ability of these double helices to associate to form gels. The results support a higher thermal stability of the ordered conformation for deacetylated RMDP17 (about 8°C), whereas deacetylated rhamsan has a better ability to form gels.
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OBJECTIVE: To establish HPLC fingerprint of Compound danshen tablets.METHODS: The separation was performed on Agilent Eclipse XDB-C18(150 mm×4.6 mm,5μm) column with mobile phase consisted of acetonitrile-0.04% phosphate (gradient elution) at flow rate of 1.0 mL·min-1.Detection wavelength was set at 272 nm and column temperature was 30℃.RESULTS: Established HPLC fingerprint was distinct and reproducible.There were 8 characteristic peaks among which No.5 characteristic peaks,No.6,No.7,No.8 came from HPLC fingerprint of Salvia miltiorrhiza and No.1 characteristic peaks,No.2,No.3,No.4 came from HPLC fingerprint of Panax notoginseng.CONCLUSION: The characteristic peaks of effective parts of Compound danshen tablet mainly come from S.miltiorrhiza.The study can be used for tracing and isolation of effective part of Compound danshen tablet and establishes basis for the further development of Chinese patent drugs.
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eng_Latn
| 32,137 |
REACTION GAS CHROMATOGRAPHY IN ANALYSIS
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CONTENTS I. Introduction 470 II. Pyrolysis 471 III. Cracking 473 IV. Hydrogenation and dehydrogenation 473 V. Dehydration and decarboxylation 474 VI. Esterification 474 VII. Saponification 475 VIII. Formation of non-volatile compounds 475 IX. Oxidation of organic compounds 477 X. Determination of water 478 XI. Qualitative chemical reactions 478
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Documentary indications of the British patent specification 14 79 444 are traced through various machine-readable stores (OTAF, DERWENT, CASEARCH, CLAIMS/US) and various printed collections (claims of German Offenlegungsschriften, US and GB abstracts and Chemical Abstracts). The traceability of patents such as GB 14 79 444 (electrolytic cell with diaphragm and titanium anodes with a catalytically active coating of platinum or ruthenium and their compounds) using the IPC and free text terms is compared. Symptomatically, it was found that free text searches go further than IPC searches, because they can reach a greater search depth.
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yue_Hant
| 32,138 |
J-TYPE DIPOLE STACKING AND STRONG π-π INTERACTIONS IN THE CRYSTALS OF DISTYRYLBENZENE DERIVATIVES: THE CRYSTAL STRUCTURES, HIGH LUMINESCENCE PROPERTIES AND PREDICTION OF HIGH MOBILITY
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The crystal structures of three analogs of trans-DPDSB (2,5-diphenyl-1,4-distyrylbenzene with two trans double bonds) are very similar to that of rubrene, which have face-to-face molecular packing mode with relative displacement along the molecular long axis. The very strong intermolecular π-π interactions enable the crystal to have the potential of high charge-carrier mobility predicted by the theoretical calculations. Most important, the crystals of these materials have very high photoluminescence (PL) efficiency of about 50% due to the J-type dipole stacking, which is different from the crystal of rubrene. The crystal structures give the prediction of combining both high luminescence and high mobility in one crystal by constructing J-type dipole stacking with strong π-π interactions.
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Objective:HPLC fingerprints of Jianwei Xiaoshi tablets were established to provide an effective method of quality control for it.Method: XDB C18 column was used with acetonitrile-0.1% phosphate aqueous as the mobile phase by gradient elution;the flow rate was 1.0 mL·min-1,and the detection wavelength was at 220 nm.Fingerprint similarity evaluation software was used to determine common fingerprint peaks,calculate the similarity,and compared with 4 counterfeit Jianwei xiaoshi tablets on the market.Result: Under 13 Jianwei Xiaoshi tablets in Jiang's fingerprint,17 common peaks were identified,the similarity was greater than 0.97,and the similarity of fingerprint of counterfeit products was less than 0.90.Conclusion: HPLC fingerprint established has better precision and reproducibility,and can effectively characterize the quality of Jianwei Xiaoshi tablets and control the product quality.
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yue_Hant
| 32,139 |
Preozonation To Improve And Optimize Diatomaceous Earth Filtration
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The benefits of preozonation before diatomaceous earth filtration have been demonstrated in a City of New York research program to develop design criteria for treatment of its 300 mgd Croton water supply. In the treatment of a supply where paniculate matter is predominantly of organic origin, preozonation provides two outstanding advantages that are not possible in diatomaceous earth filtration alone.
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Abstract The stereospecific preparation of (±) 18,19-epoxy-14,15,16-trisnorclerodan-13-oic acid is described. This compound can serve as a key intermediate in the preparation of clerodane diterpenes as it possesses the right stereochemistry at all asymmetric centres.
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kor_Hang
| 32,140 |
Determination of gangliosides by high-performance liquid chromatography with photodiode-array detection
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Abstract Mixtures of gangliosides were separated by high-performance liquid chromatography (HPLC) on amino-silica columns according to their negative charge and the length of the carbohydrate portion. The use of an on-line variable wave-length diode-array detector allows the identification of gangliosides on the basis of their UV spectra with maximum absorbance at 196 nm. Accurate analytical data acquired with the diode-array detector allow the qualitative and quantitative determination of gangliosides and therefore eliminate the need for thin-layer chromatography after HPLC separation.
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Abstract : Previous studies have shown that polymeric materials may be synthesized from substituted phenols and aromatic amine compounds through a Horseradish Peroxidase (HRP) enzyme catalyzed reaction in the bulk. We have developed a novel approach for this enzyme mediated polymer synthesis which involves in-situ polymerization using a Langmuir-Blodgett (LB) technique. Here, the LB technique is used to organize and manipulate the reactants during polymerization at the molecular level. This methodology provides direct control over the resulting structure, order and orientation of the final polymeric material. This enhanced control leads to improved processability, tensile strength, and functional properties for the polymers. This new synthetic approach and the resultant ordered polymer product can form the basis for intelligent material design. Langmuir-Blodgett, Horseradish peroxidase, Aromatic amine, Enzyme, Phenol.
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eng_Latn
| 32,141 |
STUDIES ON THE TLC IDENTIFICATION METHOD AND THE LIMIT CONTROL FOR ACONITINE OF XUEBAO CAPSULES
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OBJECTIVE:To establish the quality control standard of Xuebao Capsules. METHODS:Applying the technique of TLC to identify the main ingredients Fructus Psoraleae , Radix Polygoni multiflori prepared, Pericarpium Citri reticulatae, Radix Ginseng, Radix Astragali by using chemical reference substance or reference crude drug.RESULTS: Fructus Psoraleae, Radix Polygoni multiflori prepared, Pericarpium Citri reticulatae , Radix Ginseng , Radix Astragali could be detected by TLC.CONCLUSION:The methods were practical, special and reproducible.
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In this article,the author mainly discusses how to stimulate students to study interest and initiative,which can makes it a quick to master thinking of TCM and correctly guiding the students entered the temple of TCM.The methods for young tutor to choose are follows,such as training the students' thinking of TCM,combining theory with clinical practice,organizing students lecture,etc.In the end,the author points out that the way to improve teaching ability is that young tutor should go to hospital and listen to the professor's teaching on regular.
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yue_Hant
| 32,142 |
Some characterization of 1-(2-aminoethyl)-piperazine copper(II) chloride, a five coordinate complex
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Abstract A 1-(2-aminoethyl)piperazine copper(II) chloride complex was prepared and characterized. A square pyramidal structural scheme is proposed, but the structure of the molecule has not been confirmed by single crystal x-ray or esr data.
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Objective:To establish the quality standard for Chaihuang Liqi capsules.Methods:Radix Bupleuri and Radix Paeoniae Alba were identified by TLC,and the content of Baicalin was determined by HPLC.Results:Radix Bupleuri and Radix Paeoniae Alba could be identified by TLC.The determination of Baicalin showed a good linear relationship in the range of 80.15～721.35ng (r=0.9998).The average recovery was 99.08% with RSD of 0.83%(n=6).Conclusion:The method is simple,rapid and accurate.It can be used for quality control of Chaihuang Liqi capsules.
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eng_Latn
| 32,143 |
The crystallization of lysozyme and thaumatin with ionic liquid
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Three different ionic liquids (ILs) were used for the crystallization of lysozyme and thaumatin. It would be a promising solvent for applications in protein chemistry, due to its unusual features such as excellent solubility of inorganic and organic materials, enhancement of protein activity and stability, etc. Here, [BMIm][BF4] was used as precipitants or union-precipitants in the experiments of thaumatin and lysozyme, respectively. And the experimental results indicated that the probability of single crystals appearance was significantly increased with the addition of [BMIm][BF4].
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Object of the present invention to provide a granular preparation hours even in average particle diameter, can be effectively controlled drug dissolution characteristics. The present invention provides a granule formulation, wherein that the first coating layer containing a water-insoluble polymer particles and inorganic particles and granular formulations of a drug having a first cladding layer of the coated drug particles and / or lipid components, the lipid component contains more C15 fatty acids.
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eng_Latn
| 32,144 |
Preparation method of azilsartan impurity standard substance
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The invention discloses a preparation method of an azilsartan impurity standard substance. The preparation method comprises the following steps: hydrolyzing the raw material azilsartan by inorganic acid to obtain a crude product, and refining the crude product to obtain the 2-oxo-3-[[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazolyl-3-yl)bis-phenyl-4-yl]methyl]-2,3-dihydro-1H-benzimidazolyl-4-carboxylic acid pure product. The impurity preparation method disclosed by the invention has the advantages of cheap and accessible raw materials, simple technique and short preparation period; and the calibrated product content is greater than 98.5%. The azilsartan impurity can be used as an impurity standard substance in qualitative and quantitative research and detection on the azilsartan raw material and preparation impurities thereof.
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The present invention relates to a novel protein kinase for improved bicyclic heteroaryl derivatives inhibitory activity, pharmaceutically acceptable salts, hydrates and solvates thereof, for the prevention or treatment of abnormal cell growth disease comprising the bicyclic heteroaryl derivatives, their pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof as an active ingredient of a pharmaceutical composition.
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eng_Latn
| 32,145 |
Isolation of Cross-Coupling Products in Model Studies on the Photochemical Modification of Proteins by Tiaprofenic Acid
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To gain insight into the chemical nature of drug-induced photoallergy, model studies have been carried out on the photochemical modification of proteins by tiaprofenic acid. Irradiation of decarboxylated tiaprofenic acid (DTPA) in the presence of p-cresol leads to C–C- and C–O-connected p-cresol “dimers”, together with DTPA hydrodimers. The p-cresol–DTPA cross-coupling product was not detected in this reaction. However, a product of this type is formed using a more hindered phenol, such as 2,6-di-tert-butylphenol. Similar results are obtained when tiaprofenic acid (TPA) or its methyl ester are used as photosensitizers. The observed formation of “dimers” can be related to protein photo-crosslinking, through the coupling of two tyrosine units. On the other hand, phenol–(D)TPA cross-coupling may be relevant to the understanding of drug–protein photobinding.
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Objective To study the best extracting technology of Compound Taizishen Granule prescription.Methods The total polysaccharides and total saponins were determined by UV spectrophotometer.With the content of total polysaccharides and total saponins as comprehensive indexes,orthogonal test was applied to investigation of the water addition,extraction time,and extraction times for optimizing the best extracting technology.Results The best extracting technology was using 10 times the amount of water,extracting 3 times and 1.5 h per time.Conclusion The extraction technology is safe and effective,which can be used as extraction for Compound Taizishen Granule prescription.
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eng_Latn
| 32,146 |
Medicament for treating haemorrhoids and preparation method thereof
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The invention discloses a medicament for treating haemorrhoids and a preparation method thereof. The medicament is mainly prepared from dandelion, golden cypress, red peony root, tree peony bark, peach kernels, blackberry lily, processed armadillo scale, fructus cannabis, amaranth, liquorice, baical skullcap root, garden burnet root, hairyvein agrimony, Chinese arborvitae twig and til kernels in a certain weight proportion. The medicament has the functions of clearing away heat and toxic materials, activating blood circulation and removing blood stasis, softening hardness to dissipate stagnation, promoting astriction and stem desertion and stopping bleeding and relieving pain, and has the advantages of quick response in haemorrhoids treatment, good curative effect, relapse prevention and high heal rate.
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X-ray microscopy supplies the actual morphology of hematite aggregates in an aqueous dispersion medium. The fractal dimension of hematite aggregates has been determined below and above the critical coagulation concentration. The box-counting method has been used as a morphometric tool. The values obtained are not in accordance with the values produced by numerical approaches.
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eng_Latn
| 32,147 |
Production and Market Analysis of L-Phenyalanine
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This paper analysis the overseas and domestic producting, consuming and market situation, the comprehensive utilization during its production processing and the environmental evaluation of L- phenyalanine.
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The present invention relates to vectors useful for the administration of active principles (PA), preferably medicinal or nutritional, especially orally or parenterally. The technical problem solved by the invention is that consisting in the supply of vectors formed by (nano) or (micro) particles based on polyamino acids, and which are inert with respect to PA (proteins), of controllable granulometry, resistant and economical. The invention has an average particle size of less than 200 mum and consists of a polyamino acid of the Leu / Glu type, in which Leu / Glu + Leu> = 20% and Mw> = 10,000 D.
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eng_Latn
| 32,148 |
Investigation of RSL09 gene function in rishirilide biosynthesis in Streptomyces bottropensis
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Rishirilide is an important secondary metabolite which takes part to type II polyketides. The chemical structure and the biosynthetic pathway are already known, but nothing in deep is known about RSL09 and it's role in rishirilide production. In this work the aim of RSL09 has been investigated in the biosynthetic pathway of rishirilide.
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[Formula 1] The present invention provides a group of piperazine derivatives mesylate, and a method for the preparation of these mesylates in high yield and high purity economical way. According to the method of the present invention, synthesis of the piperazine ring and the mesylate product are combined in a single reaction step. The present invention, X is a bicyclic heterocyclic phenyl group and Y is methyl, (optionally substituted by fluorine in some cases) ethyl, cycloalkyl (3-7C) methyl, benzyl or m- phenyl benzyl in which, on the mesylate of the compound of formula (1).
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eng_Latn
| 32,149 |
Azelastine HCl: A Review of the Old and New Formulations
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Azelastine HCl (Astelin™) is an intranasal antihistamine indicated for use in patients with seasonal allergic rhinitis (SAR) and non-allergic vasomotor rhinitis (VMR). A side effect of this medication is bitter taste which many patients find aversive. To address the issue of bitter taste, azelastine has been reformulated to include sucralose and sorbitol. The new formulation (Astepro™ 0.1%) is approved for seasonal and perennial allergic rhinitis and has been demonstrated to have comparable pharmacokinetics, pharmacodynamics and therapeutic efficacy compared to Astelin. More recently, Astepro at a concentration 0.15% has been approved for once a day use. This review will provide an overview of the old and new formulations of Azelastine.
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Objective:HPLC fingerprints of Jianwei Xiaoshi tablets were established to provide an effective method of quality control for it.Method: XDB C18 column was used with acetonitrile-0.1% phosphate aqueous as the mobile phase by gradient elution;the flow rate was 1.0 mL·min-1,and the detection wavelength was at 220 nm.Fingerprint similarity evaluation software was used to determine common fingerprint peaks,calculate the similarity,and compared with 4 counterfeit Jianwei xiaoshi tablets on the market.Result: Under 13 Jianwei Xiaoshi tablets in Jiang's fingerprint,17 common peaks were identified,the similarity was greater than 0.97,and the similarity of fingerprint of counterfeit products was less than 0.90.Conclusion: HPLC fingerprint established has better precision and reproducibility,and can effectively characterize the quality of Jianwei Xiaoshi tablets and control the product quality.
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eng_Latn
| 32,150 |
ChemInform Abstract: Diversity-Oriented Enantioselective Synthesis of Highly Functionalized Cyclic and Bicyclic Alcohols.
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A highly regio- and enantioselective Cu-catalyzed hetero-allylic asymmetric alkylation with functionalized Grignard reagents is developed.
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OBJECTIVE: To establish HPLC fingerprint of Compound danshen tablets.METHODS: The separation was performed on Agilent Eclipse XDB-C18(150 mm×4.6 mm,5μm) column with mobile phase consisted of acetonitrile-0.04% phosphate (gradient elution) at flow rate of 1.0 mL·min-1.Detection wavelength was set at 272 nm and column temperature was 30℃.RESULTS: Established HPLC fingerprint was distinct and reproducible.There were 8 characteristic peaks among which No.5 characteristic peaks,No.6,No.7,No.8 came from HPLC fingerprint of Salvia miltiorrhiza and No.1 characteristic peaks,No.2,No.3,No.4 came from HPLC fingerprint of Panax notoginseng.CONCLUSION: The characteristic peaks of effective parts of Compound danshen tablet mainly come from S.miltiorrhiza.The study can be used for tracing and isolation of effective part of Compound danshen tablet and establishes basis for the further development of Chinese patent drugs.
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eng_Latn
| 32,151 |
Static Perimetry in Canthaxanthin Maculopathy
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• We performed threshold static perimetry on 19 patients who had ingested canthaxanthin; 11 had maculopathy and eight did not. Patients with no history of canthaxanthin ingestion served as controls. All patients had visual acuity of 6/9 or better. Threshold static perimetry was reevaluated two to three years after cessation of canthaxanthin ingestion. For both testing sessions, patients with maculopathy presented lower retinal sensitivity than controls, while patients without maculopathy did not differ significantly from the control group. These results suggest that canthaxanthin retinopathy can adversely affect the neurosensory retina.
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The present invention relates to a method for checking CMIs trace resin is in the field of traditional Chinese medicine injection safety evaluation. The method of the present invention, first the principle of molecular sieve macromolecular species in traditional Chinese medicine injections different degrees enriched enriched liquid prepared macromonomer, further enriched liquid inspection macromolecules, i.e. the residue obtained was extracted with chloroform, and then glacial acetic acid check solubility residue; to facilitate the observation result, the need of glacial acetic acid is centrifuged, the traditional Chinese medicine injections can check the presence of a resin, the sensitivity is significantly higher than the "Chinese Pharmacopoeia" method. By adjusting the sample volume and the enrichment ratio can be easily checked for sensitivity adjustment to check for resin injection particular medicine can be used for safety evaluation of TCM injections.
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eng_Latn
| 32,152 |
Water-borne anticorrosion coating and preparing method thereof
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The invention provides water-borne anticorrosion coating and a preparing method thereof and belongs to the technical field of coating. The coating comprises following components by weight: 10-45% of water-borne epoxy resin, 5-20% of silica sol, 5-15% of anticorrosion pigment, 20-40% of pigment and fillers, 0.5-5% of an auxiliary agent and 10-15% of water, wherein the anticorrosion pigment is one of zinc phosphate, modified zinc phosphate and zinc molybdate, or a mixture at any ratio of some compounds selected from zinc phosphate, modified zinc phosphate and zinc molybdate; and the auxiliary agent is a mixture of a lubricant, a dispersant, a coalescing agent, a pH conditioner, a defoamer and a rheological agent at any ratio. The coating has excellent adhesive force to metals, excellent corrosion resistance, excellent hardness and excellent chemical resistance, and can resist salt fog for more than 1000 h.
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Abstract Through investigating the interaction between copper metal and egg whites as well as the effects of pH, oxygen and the species of alkalis on copper corrosion rate, an unusual severe corrosion of copper metal in a highly alkaline egg white solution was found. The mechanism was investigated through detailed characterizations using a scanning electron microscope, X-ray diffraction, X-ray photoelectron spectroscopy and UV–visible absorption spectroscopy. The severe corrosion was mainly due to the formation of a hydroxyl–peptide–copper multicomponent stable soluble complex, which the biuret reaction also produces.
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eng_Latn
| 32,153 |
Determination of Gliclazide Tablets by Spectrophotometry
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A spectrophotometry method for determination of gliclazide tablets was established, using ethanol as solvent, at detection wavelength of 228 nm, the linear range was 3.2~16.0 mg/L ( r = 0.9999). The average recovery was 100.65%, with RSD 0.39%.
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A process for preparing containing pyrazole hydrochloride pioglitazone (piogletazone) The method of coating formulation of the coating formulation, the coating formulation suitable for use as, e.g., diabetes, drugs, and has excellent formulation characteristics, such as hydrochloric pioglitazone dissolution and the like.
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eng_Latn
| 32,154 |
3D-QSAR study using CoMFA and CoMSIA methods for a series of histone H3 phosphorylation inhibitors
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Three-dimensional quantitative structure–activity relationship (3D-QSAR) analysis of inhibitory activities for a series of pyrrolotriazine derivatives against histone H3 phosphorylation (pHH3) was performed using comparative of molecular field analysis (CoMFA) and comparative of molecular similarities indices analysis (CoMSIA) techniques. 62 derivatives were used to establish and validate two models by considering a high deviation in biological activities and structural variations. Optimum CoMFA and CoMSIA models obtained from the training set were statistically significant with cross-validated correlation coefficients q2 of 0.551 and 0.621, and conventional correlation coefficients (r2) of 0.999 and 0.995, respectively. The predicted correlation coefficients of test set (R2) for CoMFA and CoMSIA were 0.835 and 0.918, respectively. Two models obtained provide guidelines to trace the features that really matter chiefly with respect to the design of novel pyrrolotriazine derivatives.
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The present invention relates to vectors useful for the administration of active principles (PA), preferably medicinal or nutritional, especially orally or parenterally. The technical problem solved by the invention is that consisting in the supply of vectors formed by (nano) or (micro) particles based on polyamino acids, and which are inert with respect to PA (proteins), of controllable granulometry, resistant and economical. The invention has an average particle size of less than 200 mum and consists of a polyamino acid of the Leu / Glu type, in which Leu / Glu + Leu> = 20% and Mw> = 10,000 D.
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eng_Latn
| 32,155 |
Compositions, kits containing polymerizable reducing agents, and methods
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The present invention (can be cured by i.e. polymerization, crosslinking, ionic, and other chemical reactions) redox polymer reductant in the reaction (i.e., reducing agent) curable containing polymerizable urea or thiourea compound functions as It provides compositions.
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Reaction of either free base benzoporphyrin, its zinc(II) complex or β-bicyclo(2,2,2)octeno appended precursor porphyrins with LiR reagents gave an entry into mono- and soluble di-meso-substituted benzoporphyrins.
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eng_Latn
| 32,156 |
Processing Different Magnesium Alloys through HPT
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High-Pressure Torsion (HPT) is widely used to refine the structure of metallic materials through the use of severe plastic deformation. This technique is used in this report to process different magnesium alloys using various processing conditions. The high hydrostatic pressure allows processing of these materials at room temperature without cracking. The structure was characterized and hardness distribution was determined at different areas of the processed samples. The results show significant structure refinement and increased hardness. The evolution of the structure and hardness depends on the alloying and HPT processing conditions.
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Objective To study the best extracting technology of Compound Taizishen Granule prescription.Methods The total polysaccharides and total saponins were determined by UV spectrophotometer.With the content of total polysaccharides and total saponins as comprehensive indexes,orthogonal test was applied to investigation of the water addition,extraction time,and extraction times for optimizing the best extracting technology.Results The best extracting technology was using 10 times the amount of water,extracting 3 times and 1.5 h per time.Conclusion The extraction technology is safe and effective,which can be used as extraction for Compound Taizishen Granule prescription.
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eng_Latn
| 32,157 |
Analysis of the Active Components in Bamboo Leaves and the Anti-microbial Effect of Their Extracts
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Using different kinds of bamboo leaves and by way of aluminum nitrate-sodium nitrite colorimetry and Forint reagent deoxidization colorimetry, the contents of total flavonoid and total hydroxybenzene were measured. They are respectively 1.18%～(2.02%) and 2.21%～2.86%. The contents of total sugar, water-soluble sugars and multi-sugar, measured by anthranone-sulphuric acid method, are respectively 14.35%～24.61%, 7.86%～11.45% and 6.49%～14.55%. The nitrogen content and protein content measured by Kjeldahl method are respectively 2.13%～2.65% and 10.24%～16.68%. Anti-microbial test results by filter paper method show that the anti-microbial activity of different bamboo leaves and that of the same organ grown in different periods are quite different; that the anti-microbial activity of Sinocalamus latiflorus Mcclure leaves is better than that of other leaves; and that bamboo leaves gathered in the second part of July and November have better anti-microbial activity than those in other months.
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The present invention discloses a dual response Polypeptide sensitized Wen Minguang yl main object smart hydrogel and preparation method thereof, poly (N- isopropylacrylamide) and a common β- cyclodextrin-modified graft polymer PELG-g- (PNIPAM / β-CD) and the modified second generation dendrimers azobenzene (Me-G2-azo) was dissolved in water to obtain a mixed sol was prepared. Wen Minguang sensitive response to the present invention bis-peptidyl poly intelligent host-guest complex comprises a hydrogel responsive to temperature and light stimuli stimulus responsiveness, ease of preparation, when the temperature-controlled optical switches, thermostat light control motor, temperature control light-controlled drug delivery and other areas has broad application prospects.
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eng_Latn
| 32,158 |
Reducing the Hygroscopicity of the Anti-Tuberculosis Drug (S,S)-Ethambutol Using Multicomponent Crystal Forms
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Ethambutol (ETB) is a chiral dibasic compound formulated and marketed as the (S,S)-ethambutol dihydrochloride, (S,S)-EDH, to treat tuberculosis. It is administered orally in a solid formulation composed of isoniazid, rifampicin, and pyrazinamide as a fixed-dose combination tablet. Because of its high hygroscopicity, (S,S)-EDH is known for catalyzing the degradation of isoniazid by rifampicin to yield isonicotinyl hydrazone. In order to avoid or even minimize these mutual drug–drug interactions, in this work we have focused on the development of less hygroscopic multicomponent solid forms of ETB. Four salts of this drug, namely, oxalate (ETBOXA), maleate, terephthalate, and trichloroacetate, were prepared via supramolecular synthesis by the slow evaporation method and characterized by X-ray diffraction (single crystal X-ray diffraction, powder X-ray diffraction), spectroscopic (Fourier transform-infrared), and thermal (thermogravimetric analysis, differential scanning calorimetry, hot stage microscopy) tec...
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The present invention is stored in the PTT A method for producing a short-fiber, polytrimethylene terephthalate is taken, can the fiber as a non-drawn bundle of the base polymer and the melt spinning, a spinning fiber through a take-off roller, after storage under non-stretching the moisture content of the bundle of 0.5 to 12% by weight and the non-drawn condition environment temperature is less than or equal to 35 ℃ of around bundles, the present invention relates to a process comprising in that the bundle undergoes a stretching step.
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eng_Latn
| 32,159 |
Aircraft fuselage and aircraft with same
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The present invention provides an aircraft fuselage and an aircraft with the same. The aircraft fuselage includes an upper fuselage and a lower fuselage. The upper and lower fuselages are connected through ultrasonic welding or gluing. The internal of the aircraft fuselage is provided with a cavity and connected with at least one opening of the lower fuselage. A power system is arranged in the cavity through the opening. In the present invention, the upper and lower fuselages of the aircraft are connected through ultrasonic welding, the aircraft is formed by one step, and the good product rate is high. Meanwhile, the aircraft fuselages are connected through the ultrasonic welding technology, thus, the upper and lower fuselages are seamless connection and the contact surface suffers from stress, and the intensity has increased substantially.
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Background/Objectives: The collection of raw phytodrugs by untrained personnel may lead to unintentional adulteration of drugs. Intentional adulteration or substitution is also a menace in the crude drug markets. Methods/Statistical Analysis: To detect the adulterants from the original ones, the crude drugs are subjected for microscopic analysis including anatomical parameters. The microscopic observations on the gross anatomical features coupled with tissue disposition and cell inclusions are more reliable techniques in the crude samples of root drugs. Findings: The present paper deals with two root drugs, popularly used in Indian System of Medicine, highlights the anatomical differences namely Aerva lanata (L.) Juss. ex Schultes and Aerva persica (Burm. f.) Merr. Application/Improvements: The possible reasons for root drug similarities and differences are discussed. Such inquire may find use further in the pharmaceutical applications of these two species.
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eng_Latn
| 32,160 |
Process for removal of hydrogen sulphide, iron pentacarbonyl and nickel tetracarbonyl from a synthesis gas stream
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As a method for removing hydrogen sulfide feed synthesis, iron penta-carbonyl, and nickel tetra carbonyl from a gas stream, the removal method comprising: (A) water, by contacting the absorbing liquid comprising a physical solvent and an amine with the feed synthesis gas stream to remove hydrogen sulfide and iron penta-carbonyl, hydrogen sulfide and iron penta carbonyl step carbonyl is of obtaining a synthesis gas stream depleted, (B) the hydrogen sulfide and iron penta carbonyl this to a synthesis gas stream depleted in contact with a solid adsorbent comprising activated carbon to adsorb the nickel tetra carbonyl, nickel tetra carbonyl this thick solid adsorbent and the purified synthesis gas stream, a and a step of obtaining. Syngas stream, hydrogen sulfide, iron penta-carbonyl, nickel tetra carbonyl
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OBJECTIVE: To establish HPLC fingerprint of Compound danshen tablets.METHODS: The separation was performed on Agilent Eclipse XDB-C18(150 mm×4.6 mm,5μm) column with mobile phase consisted of acetonitrile-0.04% phosphate (gradient elution) at flow rate of 1.0 mL·min-1.Detection wavelength was set at 272 nm and column temperature was 30℃.RESULTS: Established HPLC fingerprint was distinct and reproducible.There were 8 characteristic peaks among which No.5 characteristic peaks,No.6,No.7,No.8 came from HPLC fingerprint of Salvia miltiorrhiza and No.1 characteristic peaks,No.2,No.3,No.4 came from HPLC fingerprint of Panax notoginseng.CONCLUSION: The characteristic peaks of effective parts of Compound danshen tablet mainly come from S.miltiorrhiza.The study can be used for tracing and isolation of effective part of Compound danshen tablet and establishes basis for the further development of Chinese patent drugs.
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eng_Latn
| 32,161 |
Use of Methyl Salicylates As a Trialing Chemical Agent Simulant
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Abstract : This report's objective was to provide a comprehensive assessment of the use of methyl salicylate (MS) as a trailing chemical agent simulant for operational testing (OT) for the U.S. Army Armor and Engineering Board. MS has been used for OT as a simulant for blistering agents in hard/threat analysis, collective protection, decontamination, and detection. It's used because it satisfies most agent simulant. These criteria involve the medical/safety aspects, environmental impact, chemical/physical properties, sampling/detection/ analytical methods, agent/simulant correlations, producibility, and transportation/storage/disposal requirements associated with a simulant. In evaluating MS against previously mentioned criteria, MS can be acceptable OT trailing simulant for blistering agents in most test conditions. Keywords: Methyl salicylate; Simulant use; Simulant selection criteria; Chemical agent simulants.
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Abstract A method for introducing sulphonic acid groups on to a microparticulate silica is described. This involves formation of a mercaptopropyl bonded phase followed by oxidation to the corresponding sulphonic acid. The packing material so prepared displays cation-exchange properties and has been used to separate phenothiazines.
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eng_Latn
| 32,162 |
Studies on fungal products part 10. isolation and structures of novel bicoumarins desertorins a b and c from emericella desertorum
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Together with silvaticol (11), nidulol (12), ergosterol, paxilline (10), and mannitol, three new bicoumarins designated as desertorin A (1)(C22H18O8), B (2)(C23H20O8), and C (3)(C26H22O8) have been isolated from Emericella desertorum, strain CBS 653.73. The structures of desertorins A (1), B (2), and C (3) were determined on the basis of the spectroscopic and chemical investigations of these compounds and their derivatives i.e., as 7,7′-dihydroxy-4,4′-dimethoxy-5,5′-dimethyl-6,8′-bicoumarin, 5,5′-dimethyl-6,8′-bicoumarin, 5,5′-dimethyl-7-hydroxy-4,4′,7′-trimethoxy-6,8′-bicoumarin and 5,5′-dimethyl-4,4′,7,7′-tetramethoxy-6,8′-bicoumarin, respectively. It is interesting to note that silvaticol (11) and nidulol (12), both of the known metabolites of Aspergillus silvaticus, were isolated from the same extracts.
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ABSTRACT Inorganic chemical gels obtained by hydrolysis/condensation of organic precursors (alcoxides) contain alcohol and water mixture which fills pores of the gel. This mixture is either removed in supercritical conditions or by convective drying. During convective drying gels significantly shrink producing porous glass-like xerogels. Adding a third component called DCCA (Drying Control Chemical Additive) to sol crates a diffusional barrier which lowers the drying rate and also reduces cracking. This Paper presents formulation and solution of a rigorous model of multicomponent diffusion both in liquid and gas phase in the case of convective drying of a gel cylinder containing a ternary mixture of ethanol. water and formamide as DCCA. Details of the numerical technique and methods used for prediction of physico-chemical property data involved in the solution of the model are presented. A short discussion of the obtained results follow. The model can provide a basis for a more complex process description...
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eng_Latn
| 32,163 |
Preparation of hydrophobic organic-silicanano composites
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ABSTRACTIn this paper, we use silica nanoparticles modified by methacryloxy propyl trimethoxylsilane (KH570) as the core material, and employ polymers including hexafluorobutyl methacrylate (HFMA), dodecafluoroheptyl methacrylate (DFMA) and acrylic ester as the shell materials to prepare the hydrophobic inorganic–organic hybrid nanocomposites with a seed emulsion polymerization strategy. The size, morphologyandproperties of the core-shell structured nanoparticles are investigated by TEM and SEM. The results showthat the polymer nanocomposite has three concentric layers with silica nanoparticles in the center, acrylic polymer as the internal shell and fluorosilicone polymer as the outmost shell. By controlling the ratio of the silica nanoparticles and monomers, we can achieve each composite particle has the core-shell structure with silica nanoparticles as the core and the thin layer of fluorosilicone polymer as the shell. Compared with the traditional polymer film, the nanocomposite film shows a hydropho...
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Objective To study the best extracting technology of Compound Taizishen Granule prescription.Methods The total polysaccharides and total saponins were determined by UV spectrophotometer.With the content of total polysaccharides and total saponins as comprehensive indexes,orthogonal test was applied to investigation of the water addition,extraction time,and extraction times for optimizing the best extracting technology.Results The best extracting technology was using 10 times the amount of water,extracting 3 times and 1.5 h per time.Conclusion The extraction technology is safe and effective,which can be used as extraction for Compound Taizishen Granule prescription.
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eng_Latn
| 32,164 |
RNA isolation from high-phenolic freeze-dried tea (Camellia sinensis) leaves
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With minor modifications, we applied a previously reported RNA isolation protocol that used guanidine hydrochloride to leaves of lyophilized (freeze-dried) tea (Camellia sinensis). Plant tissue must be preserved in its collected state, especially when genome-wide expression profiles are studied. Fresh leaf tissues cannot feasibly be transferred at ultra-low temperatures from natural habitats to the laboratory. We explored the use of lyophilized tissue for RNA isolation from tea leaves. High yields of RNA (∼500 μg/g dry weight of leaf tissue) were obtained, and the RNA was suitable for all molecular biology methods tested, including Northern blotting, reverse transcription, and microarray analysis. We demonstrated that RNA obtained from freeze-dried leaf tissue was high quality, undegraded, and useful for all downstream applications.
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Objective To study the best extracting technology of Compound Taizishen Granule prescription.Methods The total polysaccharides and total saponins were determined by UV spectrophotometer.With the content of total polysaccharides and total saponins as comprehensive indexes,orthogonal test was applied to investigation of the water addition,extraction time,and extraction times for optimizing the best extracting technology.Results The best extracting technology was using 10 times the amount of water,extracting 3 times and 1.5 h per time.Conclusion The extraction technology is safe and effective,which can be used as extraction for Compound Taizishen Granule prescription.
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eng_Latn
| 32,165 |
Attenuation of reactivity by product solvation: Synthesis and molecular structure of [K{(η6-Mes)NC(H)N(Mes)}{(η6-Mes)NHC(H)N(Mes)], the first formamidinate complex of potassium
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Ambient temperature treatment of the new bulky formamidine (2,4,6-Me3C6H2)NC(H)NH(2,4,6-Me3C6H2), HFMes, with 0.5 or 1.0 equivalents of potassium hydride or potassium bis(trimethylsilyl)amide yields the first potassium formamidinate complex [K{(η6-Mes)NC(H)N(Mes)}{(η6-Mes)NHC(H)N(Mes)], which displays attenuated reactivity with respect to deprotonation and solvent replacement of the included HFMes ligand.
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OBJECTIVE: To establish HPLC fingerprint of Compound danshen tablets.METHODS: The separation was performed on Agilent Eclipse XDB-C18(150 mm×4.6 mm,5μm) column with mobile phase consisted of acetonitrile-0.04% phosphate (gradient elution) at flow rate of 1.0 mL·min-1.Detection wavelength was set at 272 nm and column temperature was 30℃.RESULTS: Established HPLC fingerprint was distinct and reproducible.There were 8 characteristic peaks among which No.5 characteristic peaks,No.6,No.7,No.8 came from HPLC fingerprint of Salvia miltiorrhiza and No.1 characteristic peaks,No.2,No.3,No.4 came from HPLC fingerprint of Panax notoginseng.CONCLUSION: The characteristic peaks of effective parts of Compound danshen tablet mainly come from S.miltiorrhiza.The study can be used for tracing and isolation of effective part of Compound danshen tablet and establishes basis for the further development of Chinese patent drugs.
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eng_Latn
| 32,166 |
Possible anti-Parkinson properties of N-(α-linolenoyl) tyrosine: A new molecule
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Abstract Tyrosine is unable to cross the blood–brain barrier and is therefore unable to improve the status of brain dopamine (DA) and to provide relief for patients with Parkinson's disease (PD) or other DA-insufficient disorders. We report the creation of an amide bond molecule [ N -(α-linolenoyl)tyrosine (NLT)] that combines tyrosine with a fatty acid mixture. NLT significantly improves the rotational behavior of rats [following unilateral striatal lesions (as a model for Parkinson's)] and overcomes the exaggerated eye-blinking induced by a potent DA-depleting agent (as a model for essential blepharospasm). These results are supported by the finding that NLT's mode of action, in striatum, is the same as the mode of action of d -amphetamine. They both induce an increase in the DA level, DA turnover and release.
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Abstract A sensitive determination method of tin by differential pulse polarography is described. Addition of tropolone to acetate supporting electrolyte at about pH 4.7 provides a 30-fold signal enhancement, giving a sensitivity comparable to that obtained in anodic stripping voltammetry, but without the need for enrichment by pre-electrolysis. The response is linear over more than three orders of magnitude (1 ng ml −1 −5 μg ml −1 Sn), allowing measurements within a wide concentration range without changes in sample preparation or measuring conditions. Large amuonts of Ti, W, Cr or Mo interfere, but can be removed completely by pre-separation of tin based on extraction with tropolone/toluene and back-extraction into the supporting electrolyte. Results for tin in water and fruit juice are consistent with those obtained by other techniques.
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eng_Latn
| 32,167 |
Robust preparation of novel imidazo[5,1-b][1,3,4]oxadiazoles.
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Cyclodehydration of amino acid-derived acyl hydrazide amides to the corresponding oxadiazoles was followed by a second dehydration event, smoothly furnishing the novel imidazo[5,1-b][1,3,4]oxadiazole motif .
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Objective:HPLC fingerprints of Jianwei Xiaoshi tablets were established to provide an effective method of quality control for it.Method: XDB C18 column was used with acetonitrile-0.1% phosphate aqueous as the mobile phase by gradient elution;the flow rate was 1.0 mL·min-1,and the detection wavelength was at 220 nm.Fingerprint similarity evaluation software was used to determine common fingerprint peaks,calculate the similarity,and compared with 4 counterfeit Jianwei xiaoshi tablets on the market.Result: Under 13 Jianwei Xiaoshi tablets in Jiang's fingerprint,17 common peaks were identified,the similarity was greater than 0.97,and the similarity of fingerprint of counterfeit products was less than 0.90.Conclusion: HPLC fingerprint established has better precision and reproducibility,and can effectively characterize the quality of Jianwei Xiaoshi tablets and control the product quality.
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eng_Latn
| 32,168 |
Fasudil-contained pharmaceutical composition
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The present invention relates to a pharmaceutical composition containing fasudil to fasudil or a salt or hydrate thereof main drug ingredient, with a pharmaceutically acceptable adjuvant composition of the solid pharmaceutical composition, which composition may be preparation aspect of the present invention into an oral solid preparation, the preparation process of the solid preparation increases the stability of fasudil light, stable quality, controllable, it can be used for the treatment of pulmonary hypertension.
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Objective:To obtain the optimum prescription and investigate the techniques of preparing the Carmofur dispersible tablets.Methods:The formulate of Carmofur dispersible tablets were optimized in terms of disintegrating time,dissolution,hardness and brittleness,by the way of orthogonal test.Results:The optimized dispersible tablet disintegrated in 3 minutes.Conclusion: The in-vitro dissolubility of the optimized Carmofur dispersed tablet is better than that of the ordinary tablet.
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eng_Latn
| 32,169 |
Large and small platelets – (when) do they differ?
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Platelets are most important to provide cellular hemostasis but also take part in inflammation and immune processes. Increased platelet size has been regarded as a feature describing a young and more reactive subpopulation until studies were published which questioned this concept. Changes of platelet size given by the mean platelet volume (MPV) were described for immune thrombocytopenia, cardiovascular disease, atherosclerosis, venous thromboembolism, chronic lung disease, sepsis, cancer associated thrombosis, autoimmune disorders and others. This review summarizes the literature on what is known about platelets with different size and describes controversies of studies with large and small platelets putting a focus on their thrombogenicity and age in functional studies and on the association of MPV with the mentioned diseases.
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Objective:HPLC fingerprints of Jianwei Xiaoshi tablets were established to provide an effective method of quality control for it.Method: XDB C18 column was used with acetonitrile-0.1% phosphate aqueous as the mobile phase by gradient elution;the flow rate was 1.0 mL·min-1,and the detection wavelength was at 220 nm.Fingerprint similarity evaluation software was used to determine common fingerprint peaks,calculate the similarity,and compared with 4 counterfeit Jianwei xiaoshi tablets on the market.Result: Under 13 Jianwei Xiaoshi tablets in Jiang's fingerprint,17 common peaks were identified,the similarity was greater than 0.97,and the similarity of fingerprint of counterfeit products was less than 0.90.Conclusion: HPLC fingerprint established has better precision and reproducibility,and can effectively characterize the quality of Jianwei Xiaoshi tablets and control the product quality.
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eng_Latn
| 32,170 |
Rapid detection of cefotaxime-resistant Escherichia coli by LC–MS
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Antibiotic resistance is an unsolved healthcare problem with increasing impact on patient management in the last years. In particular, multidrug resistance among Gram-negative bacterial strains has become the most pressing challenge. In order to deliver the most efficacious antimicrobial therapy with minimum delay, rapid diagnostic tests are required in order to detect multidrug resistant pathogens early during infection. In line with these efforts, we have developed a mass spectrometry-based assay for the rapid determination of ampicillin and cefotaxime resistance. The assay quantifies beta-lactamase activities towards ampicillin and cefotaxime within a turnaround time of 150 min, which is substantially faster than classical susceptibility testing.
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The present invention relates to a method for checking CMIs trace resin is in the field of traditional Chinese medicine injection safety evaluation. The method of the present invention, first the principle of molecular sieve macromolecular species in traditional Chinese medicine injections different degrees enriched enriched liquid prepared macromonomer, further enriched liquid inspection macromolecules, i.e. the residue obtained was extracted with chloroform, and then glacial acetic acid check solubility residue; to facilitate the observation result, the need of glacial acetic acid is centrifuged, the traditional Chinese medicine injections can check the presence of a resin, the sensitivity is significantly higher than the "Chinese Pharmacopoeia" method. By adjusting the sample volume and the enrichment ratio can be easily checked for sensitivity adjustment to check for resin injection particular medicine can be used for safety evaluation of TCM injections.
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eng_Latn
| 32,171 |
Stereoselective Total Synthesis of Natural (+)-Streptazolin via a Palladium-Catalyzed Enyne Bicyclization Approach
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The natural Z isomer of (+)-streptazolin (1), isolated from cultures of Streptomyces viridochromogenes, was synthesized in an optically pure form for the first time on the basis of a palladium-catalyzed enyne bicyclization approach in 12 steps and 4.3% overall yield from (3R,4R)-3,4-bis(benzyloxy)succinimide (5). The requisite enyne 13 for palladium-catalyzed bicyclization was prepared from 5 via N-acyliminium ion cyclization of the acetoxy lactam 9, partial reduction of 10 with DIBALH−BuLi, and conversion to the dibromo olefin 12. The best result in the palladium-catalyzed bicyclization was obtained when treated with 30 mol % Pd(OAc)2 and N,N ‘-bis(benzylidene)ethylenediamine (BBEDA) as the ligand in benzene at reflux, thus affording a 93:7 mixture of the 1,2,4a,7a,6,7-hexahydro-5H-1-pyrindine (Z)-14 along with its isomerized product (Z)-15 in 84% total yield. The isomerization of the 1,4-diene in (Z)-14 to the 1,3-diene was achieved by treatment with triiron dodecacarbonyl to generate the stable tricarb...
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The invention discloses a sterilizing composition containing pyrimidine nucleoside antibiotics and eugenol. The sterilizing composition comprises two active ingredients of pyrimidine nucleoside antibiotics and eugenol, wherein the weight ratio of the pyrimidine nucleoside antibiotics to the eugenol is (1 to 10):(10 to 1). The invention further discloses application of the sterilizing composition containing the pyrimidine nucleoside antibiotics and the eugenol to the prevention and curing of downy mildew of grapes and gray mold of strawberries. After the pyrimidine nucleoside antibiotics and the eugenol are combined to have a complementary action, the sterilizing composition has an efficient bacteriostatic action, the production of resistance is delayed, the amount of the used sterilizing composition is reduced, the safety quality is improved, and the production cost is lowered.
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eng_Latn
| 32,172 |
Thermodynamics of semicontinuous n-alcohol/ultra-low sulfur diesel blends
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Abstract Two methods for calculating activity coefficients of ultra-low sulfur diesel (ULSD) and its blends with pure alcohols (C1–C5), namely, UNIFAC-continuous and UNIFAC-Dortmund-continuous, are presented. ULSD was modeled as a continuous blend of paraffins, naphthenes, and aromatics. The molar distribution in each family was expressed as a function of carbon number using the gamma distribution function. The parameters of the distribution function can be easily fitted from experimental distillation data of ULSD and extrapolated to n-alcohol/ULSD blends. The activity coefficients obtained were used to model the ASTM D86 distillation curves. UNIFAC-Dortmund-continuous exhibited the best fitting to the experimental results. Based on that, three new correlations for calculating the boiling point, vapor pressure and structural groups of complex ULSD are proposed here.
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Aiming at the relatively high operation and maintenance cost of the desulphurization system of 2 × 600 MW unit in Huadian Energy Harbin No. 3 Power Plant,this paper introduces the current situation of the flue gas desulphurization system of the two units,analyzes the factors influencing their operation and maintenance cost,and proposes the optimization principle and specific measures of operation mode of the system. The practice proves that the optimization is able to guarantee the efficiency of desulphurization,which enables the economic indexes superior to the design value.
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eng_Latn
| 32,173 |
Determination of dissociation constants of p-hydroxybenzophenone in aqueous organic mixtures – Solvent effects
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The apparent acidity constant of p-hydroxybenzophenone, which is a practically insoluble drug in water but of great pharmaceutical interest, was determined by reversed-phase high-performance liquid chromatography in organic solvent – water mixtures (acetonitrile–water, ethanol–water, and methanol–water), varying the reaction medium permittivity in the interval 56 to 70, at constant ionic strength (0.050) and temperature (30 °C). A combined glass electrode calibrated with aqueous standard buffers was used to obtain pH readings based on the concentration scale (swpH). The pKa values from chromatographic data were obtained using the Hardcastle–Jano equation. Moreover, excellent linear relationships between the pKa values and solvation properties of the reaction medium (relative permittivity and Acity) were used to derive acid dissociation constants in aqueous solution. It has been concluded that the pKa values extrapolated from such solvent–water mixtures are consistent with each other and with previously re...
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OBJECTIVE: To establish HPLC fingerprint of Compound danshen tablets.METHODS: The separation was performed on Agilent Eclipse XDB-C18(150 mm×4.6 mm,5μm) column with mobile phase consisted of acetonitrile-0.04% phosphate (gradient elution) at flow rate of 1.0 mL·min-1.Detection wavelength was set at 272 nm and column temperature was 30℃.RESULTS: Established HPLC fingerprint was distinct and reproducible.There were 8 characteristic peaks among which No.5 characteristic peaks,No.6,No.7,No.8 came from HPLC fingerprint of Salvia miltiorrhiza and No.1 characteristic peaks,No.2,No.3,No.4 came from HPLC fingerprint of Panax notoginseng.CONCLUSION: The characteristic peaks of effective parts of Compound danshen tablet mainly come from S.miltiorrhiza.The study can be used for tracing and isolation of effective part of Compound danshen tablet and establishes basis for the further development of Chinese patent drugs.
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eng_Latn
| 32,174 |
Diagnosis of mycobacterial infections by PCR and restriction enzyme digestion.
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A method for the diagnosis of mycobacterial infections by PCR amplification followed by selective restriction enzyme digestion of the PCR product was developed. The amplified DNA sequence used in this study occurs within the gene encoding for the mycobacterial 65 kDa heat shock protein (Hance et al. 1989), which is found in all mycobacteria. However, there are minute differences in the amplified sequence from the Mycobacterium tuberculosis complex compared with the corresponding sequence from the Mycobacterium avium complex. These differences made it possible to rapidly identify to which mycobacterial complex a particular sample belonged by restriction enzyme digestion of the PCR product. A total of 66 samples were tested and all of them were correctly identified. This and similar methods should provide a sensitive, specific and rapid (within 12 h) way of diagnosing mycobacterial infections to the species level.
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The present invention relates to a method for checking CMIs trace resin is in the field of traditional Chinese medicine injection safety evaluation. The method of the present invention, first the principle of molecular sieve macromolecular species in traditional Chinese medicine injections different degrees enriched enriched liquid prepared macromonomer, further enriched liquid inspection macromolecules, i.e. the residue obtained was extracted with chloroform, and then glacial acetic acid check solubility residue; to facilitate the observation result, the need of glacial acetic acid is centrifuged, the traditional Chinese medicine injections can check the presence of a resin, the sensitivity is significantly higher than the "Chinese Pharmacopoeia" method. By adjusting the sample volume and the enrichment ratio can be easily checked for sensitivity adjustment to check for resin injection particular medicine can be used for safety evaluation of TCM injections.
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eng_Latn
| 32,175 |
A Simple and Highly Efficient Preparation of Structurally Diverse Arylβ-diketoacids as HIV-1 Integrase Inhibitors
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In order to provide a facile and practical access to structurally diverse aryl β-diketoacids, An improved and highly efficient oxalylation method was developed which employed commercially available and cheap reagents. The oxalylation of aryl methyl ketones, the key step to construct the pharmacophore of aryl β-diketoacids, was considerably facilitated by a new combination of dimethyl oxalate as an oxalic source and sodium tert-butoxide as a base. A wide variety of aryl β-diketoacids bearing different functional groups can be prepared rapidly in high yields at room temperature with this method, which has significant advantages over the previously reported procedures in a wider application range, much less amount of reagents, pretty higher yields and quite shorter reaction time. The bis-aryldiketoacids 3k and 31, readily prepared by this method, displayed interesting and promising inhibitory activities against HIV-1 integrase and HIV-1 replication in cells.
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Many sources of formation damage exists which normally contribute to a reduction in well productivity by introducing an extra positive skin near the wellbore. The main objective of matrix stimulation treatment is to remove this damage. Such treatment was a new approach in Amal formation contained within Sirt basin. The challenge faced was the need to inject Break - Down Acid Job (BDAJ) technique without inducing fractures in the formation (safety margin bottom - hole pressure value should be not be exceeded), mean while, the formation was depleted and applying high injection rate was essential to ensure that the acid reaches the targeted zone. This paper details a combination of techniques, implemented in S irt basin, which have proven to enhance the overall operations’ economics and well deliverability. Furthermore, the paper describes a novel approach for Gas Lift Analysis.
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eng_Latn
| 32,176 |
Determination of Propafenone and Its Metabolites with GC-MS
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In this paper,propafenone in judicial anatomy was quantitated and found to be 11.6 μg/mL in blood,17.8 μg/mL in urine,292 μg/g in gastric content and 196 μg/g in liver with GC-MS. Two metabolites from propafenone have been defined.In conclusion,as the dead body himself is a drug abuser and also his blood concentration of propafenone exceed the fatal dose,this case is finally identified to a death cause from the overdose of propanenone abuse.
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The present invention relates to a method for checking CMIs trace resin is in the field of traditional Chinese medicine injection safety evaluation. The method of the present invention, first the principle of molecular sieve macromolecular species in traditional Chinese medicine injections different degrees enriched enriched liquid prepared macromonomer, further enriched liquid inspection macromolecules, i.e. the residue obtained was extracted with chloroform, and then glacial acetic acid check solubility residue; to facilitate the observation result, the need of glacial acetic acid is centrifuged, the traditional Chinese medicine injections can check the presence of a resin, the sensitivity is significantly higher than the "Chinese Pharmacopoeia" method. By adjusting the sample volume and the enrichment ratio can be easily checked for sensitivity adjustment to check for resin injection particular medicine can be used for safety evaluation of TCM injections.
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eng_Latn
| 32,177 |
Development and evaluation of matrix and two layered sustained release suppositories of nimesulide
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Nimesulide loaded conventional suppositories, sustained release matrix suppositories and sustained release two layered suppositories were prepared using polyethyleneglycol (PEG) 4000 and ethylcellulose. In vitro characteristics of these suppositories were evaluated. In comparison to conventional suppositories the release of drug from sustained release matrix suppositories was gradual and extended over a period of time. On the other hand, two layered suppositories produced an initial quick release followed by extended release of drug.
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Drug delivery device implantable in the drug contained in the housing and drug reservoir lumen having a drug reservoir lumen, which is closed surrounded by the first wall structure and a hydrophilic second wall structure wherein, here, the first wall structure is impervious to the drug, and the second wall structure is permeable to the drug. Method of providing drug in controlled release to the patient may place the drug delivery device to the patient, to release the drug from the drug reservoir lumen via diffusion through the second wall structure including. .FIELD 8A
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eng_Latn
| 32,178 |
Hydrothermal Synthesis,Crystal Structure and Luminescence Property of 1D Chain Coordination Polymer [Eu_2(C_(10)H_9NO_2)_6(H_2O)_2]_n
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The coordination polymer [Eu2(C10H9NO2)6(H2O)2]n with o-acetamidobenzoic acid and 1,10-phenanthroline has been synthesized by means of hydrothermal way and characterized.It crystallizes in the monoclinic space group P21/n,with a=1.074 19(10) nm,b=1.063 39(9) nm,c=2.496 7(2) nm,β=100.2610(10) °.The crystal structure shows that four bi-dentate bridging o-acetamidobenzoic acid groups and two europium(Ⅲ) ions form a binuclear cage structure in [Eu2(C10H9NO2)6(H2O)2]n,where the distance between Eu(1) and Eu(1A) is 0.428 9 nm.Two neighboring cage structures are linked together by two o-acetamidobenzoic acid and the complex molecule forms an one-dimensional chain structure.In the complex,the europium(Ⅲ) ion is coordinated with eight oxygen atoms from seven o-acetamidobenzoic acid molecules and one water molecule,forming a distorted square antiprism coordination geometry.The luminescence property of the complex was also studied.CCDC:674226.
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OBJECTIVE: To establish HPLC fingerprint of Compound danshen tablets.METHODS: The separation was performed on Agilent Eclipse XDB-C18(150 mm×4.6 mm,5μm) column with mobile phase consisted of acetonitrile-0.04% phosphate (gradient elution) at flow rate of 1.0 mL·min-1.Detection wavelength was set at 272 nm and column temperature was 30℃.RESULTS: Established HPLC fingerprint was distinct and reproducible.There were 8 characteristic peaks among which No.5 characteristic peaks,No.6,No.7,No.8 came from HPLC fingerprint of Salvia miltiorrhiza and No.1 characteristic peaks,No.2,No.3,No.4 came from HPLC fingerprint of Panax notoginseng.CONCLUSION: The characteristic peaks of effective parts of Compound danshen tablet mainly come from S.miltiorrhiza.The study can be used for tracing and isolation of effective part of Compound danshen tablet and establishes basis for the further development of Chinese patent drugs.
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eng_Latn
| 32,179 |
Effect of Riboflavin Solution With Hydroxypropyl Methylcellulose and Eyelid Speculum on Pachymetry Changes During Accelerated Collagen Crosslinking.
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Purpose:To assess corneal thickness changes with isotonic riboflavin (RF) solution with hydroxylpropyl methylcellulose in patients undergoing accelerated corneal collagen crosslinking (CXL) with and without an eyelid speculum.Methods:Fifty-two eyes of 48 patients with progressive keratoconus were en
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The lambda carrageenan/HPMC ratio in matrix tablets has been optimized in order to obtain pH-independent release profiles of chlorpheniramine maleate, a freely soluble drug. Release profiles in acidic (pH1.2) and neutral (pH 6.8) media were fitted according to the Weibull and the power law models. Model independent parameters(t50% and the percentage of drug released after 2 h) were also calculated. The Weibull parameters were found suitable to describe the dependence of the release profiles on matrix composition. Preparation and testing of the optimized formulation showed linear and pH-independent release profiles lasting about 24 h, in good accordance with the values predicted by the optimization procedure.
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eng_Latn
| 32,180 |
The Polycomb Protein Ezh2 Impacts on Induced Pluripotent Stem Cell Generation
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Reprogramming of somatic cells toward pluripotency involves extensive chromatin reorganization and changes in gene expression. Polycomb group (PcG) proteins are key regulators of chromatin structure, cell identity, and development. In this study, we investigated the impact of Ezh2, a core subunit of Polycomb repressive complex 2 (PRC2), on the generation of induced pluripotent stem (iPS) cells. We found that Ezh2 expression is induced during iPS cell generation and iPS cells contain high levels of Ezh2 mRNA and protein. Importantly, shRNA knockdown of Ezh2 during reprogramming severely impairs iPS cell generation. Mechanistically, Ezh2 acts during reprogramming at least in part through repressing the Ink4a/Arf locus, which represents a major roadblock for iPS cell generation. Interestingly, knockdown of Ezh2 in established pluripotent cells leaves pluripotency and self-renewal of embryonic stem cells and iPS cells unaffected. Altogether, our results demonstrate that Ezh2 is critical for efficient iPS cell...
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Objective To study the best extracting technology of Compound Taizishen Granule prescription.Methods The total polysaccharides and total saponins were determined by UV spectrophotometer.With the content of total polysaccharides and total saponins as comprehensive indexes,orthogonal test was applied to investigation of the water addition,extraction time,and extraction times for optimizing the best extracting technology.Results The best extracting technology was using 10 times the amount of water,extracting 3 times and 1.5 h per time.Conclusion The extraction technology is safe and effective,which can be used as extraction for Compound Taizishen Granule prescription.
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eng_Latn
| 32,181 |
In vitro screening of traditional medicines for anti-hypertensive effect based on inhibition of the angiotensin converting enzyme (ACE).
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Traditional medicines reported to be used as anti-hypertensives or diuretics from different regions in the world (China, India and South America) have been investigated. The bioassay is based on inhibition of ACE, as measured from the enzymatic cleavage of the chromophore-fluorophore-labelled substrate dansyltriglycine into dansylglycine and diglycine. In total, 31 species have been investigated and the crude extracts from seven species inhibit the enzyme by more than 50%.
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Abstract : Previous studies have shown that polymeric materials may be synthesized from substituted phenols and aromatic amine compounds through a Horseradish Peroxidase (HRP) enzyme catalyzed reaction in the bulk. We have developed a novel approach for this enzyme mediated polymer synthesis which involves in-situ polymerization using a Langmuir-Blodgett (LB) technique. Here, the LB technique is used to organize and manipulate the reactants during polymerization at the molecular level. This methodology provides direct control over the resulting structure, order and orientation of the final polymeric material. This enhanced control leads to improved processability, tensile strength, and functional properties for the polymers. This new synthetic approach and the resultant ordered polymer product can form the basis for intelligent material design. Langmuir-Blodgett, Horseradish peroxidase, Aromatic amine, Enzyme, Phenol.
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eng_Latn
| 32,182 |
Quantification of Regional Myocardial Perfusion by Exponential Infusion of 11C-Butanol
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This study was designed to determine whether regional myocardial perfusion can be assessed quantitatively in vivo in dogs by administration of a freely diffusible tracer intravenously at an exponentially increasing-rate. Previously, we reported the mathematical basis of the approach and its use for assessment of global perfusion in isolated hearts. In this study, computer simulations demonstrated that inter-regional diffusion of tracer perturbs results by no more than 7 percent under worst case conditions. Regional myocardial blood flow assessed in open chest dogs with myocardial activity deternined by well counting by the exponential infusion method correlated closely to values obtained with radiolabeled microspheres (r = 0.986, n = 35 determinations). Thus, regional myocardial perfusion can be quantified with an infusion technique potentially applicable to the tomographic characterization of impaired perfusion in experimental animals and ultimately in patients with positron emission tomography.
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The present invention relates to a method for checking CMIs trace resin is in the field of traditional Chinese medicine injection safety evaluation. The method of the present invention, first the principle of molecular sieve macromolecular species in traditional Chinese medicine injections different degrees enriched enriched liquid prepared macromonomer, further enriched liquid inspection macromolecules, i.e. the residue obtained was extracted with chloroform, and then glacial acetic acid check solubility residue; to facilitate the observation result, the need of glacial acetic acid is centrifuged, the traditional Chinese medicine injections can check the presence of a resin, the sensitivity is significantly higher than the "Chinese Pharmacopoeia" method. By adjusting the sample volume and the enrichment ratio can be easily checked for sensitivity adjustment to check for resin injection particular medicine can be used for safety evaluation of TCM injections.
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eng_Latn
| 32,183 |
Process for preparing compounds of azo type.
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The invention relates to a method for production of azo compounds. In particular the invention relates to a step-wise method for production of an azo compound, by seeding and oxidation of the corresponding hydrazoic compound.
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13 ::: C Label exchange between the 1 and 3 positions of allyl alcohol at high temperatures on CsHX zeolite demonstrates the presence of an allyl cation as an intermediate in hydrocarbon synthesis.
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eng_Latn
| 32,184 |
Insulin glargine: A basal insulin for the management of diabetes
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The prevalence of diabetes mellitus has been increasing steadily in the last 30 years and it is predicted that there will be 300 million people affected by 2025. Insulin deficiency is a feature of both Type 1 and 2 diabetes; insulin treatment, obligatory in Type 1, will also be required in many Type 2 patients. Insulin glargine is the first available synthetic insulin that can truly be described as basal – administered as a once-daily subcutaneous injection it raises the background, or basal, insulin level without a significant peak action and less hypoglycemia than previously used basal insulins. Insulin glargine is the first basal insulin that can be administered as a single injection daily as part of an intensive basal–bolus insulin regimen in Type 1 diabetes. In Type 2 diabetes, insulin glargine, administered once daily with one or two oral hypoglycemic drugs, can enable more than 50% of patients to achieve an A1c of less than 7%. The titration of the insulin glargine dose to an appropriate level over...
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Thispaperdescribesa polyimideinterlevelmetal coat U2 insulationprocess.The use of polyimidenear high voltagedevicescan resultin anomalousleakagein Goatel certainregionsat elevatedtemperatures.The paper Optional summarizesthe reliabilityinvestigation on discrete Plasma Nitride devicesfabricatedwith polyimide,as the interlevel material,as wellas characterization datawhichsupportdesigncriteriapermittingthe use of polyimide *F as an interlevelinsulation material. *s First Coat&Partial Cure Second Coat&Full Cure Excellent Planarization
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eng_Latn
| 32,185 |
Differential susceptibility of Dectin-1 isoforms to functional inactivation by neutrophil and fungal proteases
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Patients with cystic fibrosis (CF) experience chronic or recurrent bacterial and fungal lung infections. Many patients with CF cannot effectively clear Aspergillus from their lungs. This may result in IgE sensitization and the development of allergic bronchopulmonary aspergillosis, or invasive infections, such as Aspergillus bronchitis. Lung disease in patients with CF is associated with neutrophil-dominated inflammation and elevated levels of the serine protease, neutrophil elastase (NE). Various C-type lectin-like receptors (CLRs), including Dectin-1 and Dectin-2, are involved in the immune response to Aspergillus. Here, we show that purified NE cleaves Dectin-1 in an isoform-specific manner. Bronchoalveolar lavage fluid from patients with CF, which contains high NE activity, induces Dectin-1 cleavage. Similarly, filtrate from a protease-producing strain of Aspergillus fumigatus induces isoform-specific cleavage of Dectin-1. Dectin-1 knockout (KO) cells and NE-treated cells demonstrated reduced phagocyt...
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OBJECTIVE: To establish HPLC fingerprint of Compound danshen tablets.METHODS: The separation was performed on Agilent Eclipse XDB-C18(150 mm×4.6 mm,5μm) column with mobile phase consisted of acetonitrile-0.04% phosphate (gradient elution) at flow rate of 1.0 mL·min-1.Detection wavelength was set at 272 nm and column temperature was 30℃.RESULTS: Established HPLC fingerprint was distinct and reproducible.There were 8 characteristic peaks among which No.5 characteristic peaks,No.6,No.7,No.8 came from HPLC fingerprint of Salvia miltiorrhiza and No.1 characteristic peaks,No.2,No.3,No.4 came from HPLC fingerprint of Panax notoginseng.CONCLUSION: The characteristic peaks of effective parts of Compound danshen tablet mainly come from S.miltiorrhiza.The study can be used for tracing and isolation of effective part of Compound danshen tablet and establishes basis for the further development of Chinese patent drugs.
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eng_Latn
| 32,186 |
Study on Propylparaben's Bacteriostatic Effect in Different Cosmetic Matrix
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Preservative efficacy testing method was employed to investigate the bacteriostatic effect of Nipagin esters used in different categories of cosmetic products at specific concentrations(commonly used by enterprises and standard limitation).The results showed that the disappearance of bacteria varied a lot among different types of cosmetics,and the bacteriostatic effect of preservatives were influenced due to different cosmetic matrix.
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FIELD: chemistry. SUBSTANCE: invention concerns process of production of diisopropyl {[1-(hydroxymethyl)-cyclopropyl]oxy}methylphosphonate represented by the formula , which is the key intermediate compound in synthesis of antiviral nucleoside analogue. The invention also concerns new intermediate compounds of formulae and , and their production of compound (2) obtained under this invention, which is an antiviral nucleoside analogue (especially against hepatitis B virus) represented by the formula . EFFECT: high purity grade and high output. 4 ex
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eng_Latn
| 32,187 |
Production process pachulol and 7-epi-alpha-selinene
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A process pachulol pruduccion and 7-epi-a-selinene comprising a) contacting farnesyl pyrophosphate (FPP) with at least one polypeptide having an activity pachulol and 7-epi-a-selinene synthase and comprising a amino acid sequence at least 70% identical to SEQ ID NO: 1; wherein said contacting is in vitro, or in vivo in a nonhuman organism or cell transformed to express said polypeptide; b) optionally isolating the 7-epi pachulol and-a-selinene produced in step a).
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An analysis of the schemes and parts of the boilers for the 500-MW power units burning Ekibastuz coals is made from the results of mastering and operation of these boilers. The functioning of coal pulverization systems with type MMT and MPS pulverizers and the furnace burners, as well as the economic efficiency of the schemes for burning and the NO x emissions, are considered in detail.
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eng_Latn
| 32,188 |
New process for synthetizing lythidathion
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The invention discloses a new process for synthetizing lythidathion. Mercaptamine and urea are used as initial materials to simply obtain lythidathion active compound of which the content is more than 98.0% by reactions of thiazolidone synthesis, sec-butyl mercaptan synthesis, sec-butyl phosphoryl chloride synthesis, lythidathion synthesis and the like.
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In this article, perspective using of the laser deposition method for manufacture details from the titanium alloy VT20 is considered. Dependence on a structure of the fractional composition is shown. Study of the structure and properties of parts, which were produced by DLD technology using different modes and under different conditions.
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eng_Latn
| 32,189 |
Structure and Biosynthesis of Arabinogalactan and Its Application in Mycobacteria
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One of the main compositions of mycobacterial cell wall is arabinogalactan (AG), which plays an essential role in the integrity of cell wall and in controlling the growth of the bacteria. The three constituents of AG are linker of L-Rhap-(1-3)-GlcNAc, ara- binanandgalactan. Various types and linkage of sugarunits lead to complicated AG structure.dTDP-Rha, UDP-Galf, DPA were sugar donor in the process of AG biosynthesis. The biosynthesis of AG's constituents and the sugar donors may be the site of action of powerful and potential anti-mycobacterial compound.
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OBJECTIVE: To establish HPLC fingerprint of Compound danshen tablets.METHODS: The separation was performed on Agilent Eclipse XDB-C18(150 mm×4.6 mm,5μm) column with mobile phase consisted of acetonitrile-0.04% phosphate (gradient elution) at flow rate of 1.0 mL·min-1.Detection wavelength was set at 272 nm and column temperature was 30℃.RESULTS: Established HPLC fingerprint was distinct and reproducible.There were 8 characteristic peaks among which No.5 characteristic peaks,No.6,No.7,No.8 came from HPLC fingerprint of Salvia miltiorrhiza and No.1 characteristic peaks,No.2,No.3,No.4 came from HPLC fingerprint of Panax notoginseng.CONCLUSION: The characteristic peaks of effective parts of Compound danshen tablet mainly come from S.miltiorrhiza.The study can be used for tracing and isolation of effective part of Compound danshen tablet and establishes basis for the further development of Chinese patent drugs.
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eng_Latn
| 32,190 |
Isomerization of proton-bound alcohol dimers
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Proton-bound dimers [ROH… … HOR] have been studied under chemical ionization conditions. The structures of the fragment ions and the behaviour of variously deuterated ions when R = iC3H7 lead to a proposed fragmentation pathway.
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FIELD: chemistry. SUBSTANCE: invention concerns process of production of diisopropyl {[1-(hydroxymethyl)-cyclopropyl]oxy}methylphosphonate represented by the formula , which is the key intermediate compound in synthesis of antiviral nucleoside analogue. The invention also concerns new intermediate compounds of formulae and , and their production of compound (2) obtained under this invention, which is an antiviral nucleoside analogue (especially against hepatitis B virus) represented by the formula . EFFECT: high purity grade and high output. 4 ex
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eng_Latn
| 32,191 |
Modeling and Dynamic Simulation for Mould Crystallizer Oscillation Based on ADAMS
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With the SIMULINK module,analyze the dynamic characteristic of the crystallizer oscillation mathematics model.By constructing method,input this system non-SIN function and obtains different respond curve.Additionally by changing the parameters,this system has a good respond speed.Then establishes the concise model in connection with its hydraulicsystem.After inputting the servo with subsection function,the hatch of the servo can be controlled.United simulation shows what do satisfies the non-SIN Oscillation and frequency demand of the crystallizer.
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Summary:A limited sampling model (LSM) is proposed for the first-time assessment of pharmacokinetic parameters (area under the concentration–time curve (AUC), Cmax, and T½) in children after a single oral dose of drug. Three drugs were evaluated in this study. The LSM was developed for each drug fro
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eng_Latn
| 32,192 |
Determination of the contents of cefradine in human plasma by HPLC method and studies on its pharmacokinetics
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Objective: To study the pharmacokinetics of cefradine capsules and establish a HPLC method for determining the contents of the cefradine in human plasma.Methods: The randomized,crossed-over study was carried out in 18 healthy(volunteers.) After a single dose of cefradine(500 mg),the plasma drug levels were determined by HPLC method.The column was Hypersil ODS(250 mm×4.6 mm,5 μm) and acetonitrile-water-glacial acetic acid-triethylamine(10∶(90∶)0.14∶0.16) was the mobile phase.The detection wavelength was 262 nm.The flow rate was 1.0 mL/min.Results: The main pharmacokinetic parameters of test cefradine and reference cefradine were as follows: t_(max)=(1.03±0.12) h and(1.03±0.12) h,c_(max)=((14.26±)2.11) μg/mL and(14.13±2.11) μg/mL,t_(1/2β)=(1.13±0.12) h and(1.11±0.12) h,AUC_(0~∞)=(23.41±(3.35) μg·)h·mL~(-1) and (23.14±2.92) μg·h·mL~(-1).Conclusion:The results show that the two formulations are(bioequivalent.)
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Citalopram was an effective and safe antidepressant which existed in the market for many years and had great market value.To realize the industrial production of citalopram,the process was improved based on the patent US4943590.The improved process was 4-(4-(dimethylamino)-1-(4-fluorophenyl)-hydroxy-butyl)-3-(hydroxymetheyl)-benzonitrile was dissolved in toluene at 0 ℃.Toluene sulfochloride was used as acylation reagent,HCl generated in the acylation reaction was absorbed by Na2CO3 water solution(20 wt-%).The conversion rate of the process was higher than 99%,and the purity of the product was more than 99.5%.This improved process was very easy to carry out,those chemical materials were commercialized and cheep,and low pollutant discharge,which can satisty the need of industrialized production.
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eng_Latn
| 32,193 |
Crystallization and preliminary crystallographic analysis of the ADP-ribosyltransferase HopU1. Corrigendum
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In the article by Lin et al. (2010 ▶) the gel filtration column was given incorrectly in §2.1 and in the figure caption for Fig. 2. A Superdex 75 column was used for gel filtration and not a Superdex 200 column as stated in the original article.
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Objective:HPLC fingerprints of Jianwei Xiaoshi tablets were established to provide an effective method of quality control for it.Method: XDB C18 column was used with acetonitrile-0.1% phosphate aqueous as the mobile phase by gradient elution;the flow rate was 1.0 mL·min-1,and the detection wavelength was at 220 nm.Fingerprint similarity evaluation software was used to determine common fingerprint peaks,calculate the similarity,and compared with 4 counterfeit Jianwei xiaoshi tablets on the market.Result: Under 13 Jianwei Xiaoshi tablets in Jiang's fingerprint,17 common peaks were identified,the similarity was greater than 0.97,and the similarity of fingerprint of counterfeit products was less than 0.90.Conclusion: HPLC fingerprint established has better precision and reproducibility,and can effectively characterize the quality of Jianwei Xiaoshi tablets and control the product quality.
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eng_Latn
| 32,194 |
Enol lactone derivatives as inhibitors of human neutrophil elastase and trypsin-like proteases
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Abstract We report on the development of substituted valero enol lactones as powerful inhibitors of human neutrophil elastase (HNE) by valine mimic enol lactones and trypsin-like enzymes (trypsin, plasmin, urokinase, t-PA, and thrombin) by guanidino-aryl substituted enol lactones.
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The work by Levis andRabitz in the field of laser control achieved great importancedue to their result of having controlled a complex bondrearrangement reaction (Scheme 2, in ref 2; Scheme 3c in ref3), specifically the production of toluene starting from acetophe-none (see Figure 1 insert). Their original experiment wasreported to
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eng_Latn
| 32,195 |
How to therapeutic acid ceramidase compositions and making and using the same
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A ceramidase mixture comprising an inert acid ceramidase precursor and active acid ceramidase relates to therapeutic compositions comprising a pharmaceutically acceptable carrier. Also relates an acidic ceramidase used in acid ceramidase treatment, comprising the step of formulating as ceramidase mixture containing an inert acid ceramidase precursor and active acid ceramidase, to a method of acid ceramidase treatment. Further, step provides a medium containing inert acid ceramidase precursor; inert acidic incubating the medium under conditions effective to convert a portion of the ceramidase precursor into the active acid ceramidase; and incubated medium and including the step of recovering a ceramidase mixture containing an inert acid ceramidase precursor and active acid ceramidase, relates to a method of producing a therapeutic composition. Also it relates to the preparation of therapeutic compositions of the ceramidase lacking acidic sphingomyelinase.
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Objective To study the best extracting technology of Compound Taizishen Granule prescription.Methods The total polysaccharides and total saponins were determined by UV spectrophotometer.With the content of total polysaccharides and total saponins as comprehensive indexes,orthogonal test was applied to investigation of the water addition,extraction time,and extraction times for optimizing the best extracting technology.Results The best extracting technology was using 10 times the amount of water,extracting 3 times and 1.5 h per time.Conclusion The extraction technology is safe and effective,which can be used as extraction for Compound Taizishen Granule prescription.
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eng_Latn
| 32,196 |
Investigation and prevention of intracranial infection caused by Acinetobacter baumannii after continued external ventricular drainage
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OBJECTIVE To study the prevention strategy of the intracranial infection caused by Acinetobacter baumannii.METHODS Totally 3 cases of the intracranial infection caused by A.baumannii in the ICU from Apr to Jul 2010 were analyzed.RESULTS One case died,1 case was disability,1 case was cured and discharged after comprehensive treatments,which included anti-infection and strengthening isolation.CONCLUSION The intracranial infection caused by A.baumannii is very serious.The infection factors are related to the invasive operation such as long time external ventricular drainage,extensive use of the broad-spectrum antibiotics and the contaminated environment of the ward.
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Volatile fatty acids (VFAs) are produced in the anaerobic digestion of urban or food wastes and sewage sludge. The interest in these compounds has increased because of their use as platform chemicals. In this paper, the application of natural terpenoids and eutectic solvents to sustainably recover VFAs from aqueous solutions by extraction has been evaluated. First, a screening of solvents has been done using COSMO-RS, selecting three terpenoids: geraniol, citral, and eugenol, and two hydrophobic eutectic solvents formed by octanoic acid and menthol or thymol. These solvents have been tested in the extraction of acetic, propionic, butyric, and valeric acids. The highest yields were obtained using geraniol and the (octanoic acid + thymol) eutectic solvent, being comparable or higher than those for organic solvents from the literature. The back-extraction of the VFAs from both solvents has been studied using NaOH and Na2CO3 solutions, concluding that the eutectic solvent is not chemically stable to be reused...
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eng_Latn
| 32,197 |
Traditional Chinese medicine combination for treating cholelithiasis
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The invention discloses a traditional Chinese medicine combination for treating cholelithiasis. The traditional Chinese medicine combination comprises the following traditional Chinese medicine raw materials, namely radix paeoniae alba, trogopterus dung, lysimachia christinae hance, endothelium corneum gigeriae galli, veronicastrum sibiricum, semen plantaginis, cornu cervi degelatinatum, rhizoma corydalis, toosendan fruit, liquorice, moutan bark, loranthus parasiticus, eucommia ulmoides and curcuma aromatica. The traditional Chinese medicine combination for treating cholelithiasis is obvious in cholelithiasis treating effect, medicine taking is safe, no side effects exist, and the traditional Chinese medicine combination can be easily accepted by a patient.
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According to characteristics of local building materials of Kunming,"multiple-admixture" technique and orthogonal design method are adopted to satisfy concrete strength.Preparation and application of self-compacted C60 high-strength and high-performance pumped concrete are analyzed with consideration of various factors,including construction process and filed environmental conditions,etc.Such concrete is used in provincial key project on certain purpose,and favorable effects are obtained.
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eng_Latn
| 32,198 |
Cause Analysis on Heat Affected Zone Cracking of Weldments of 16MnD5 Steel
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Cause analysis was conducted on the heat affected zone(HAZ) cracking of a high strength low alloy 16MnD5 steel plate weldment by the methods of chemical compositions analysis,macroscopic examination,metallographic examination and microhardness test.The results show that the crack began from the coarse grain zone of the HAZ,and extended in the mixed manner of intergranular and transgranular.The crack was cold crack which was mainly caused by residual stress and the base metal's tendentiousness of harden quenching.
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OBJECTIVE: To establish HPLC fingerprint of Compound danshen tablets.METHODS: The separation was performed on Agilent Eclipse XDB-C18(150 mm×4.6 mm,5μm) column with mobile phase consisted of acetonitrile-0.04% phosphate (gradient elution) at flow rate of 1.0 mL·min-1.Detection wavelength was set at 272 nm and column temperature was 30℃.RESULTS: Established HPLC fingerprint was distinct and reproducible.There were 8 characteristic peaks among which No.5 characteristic peaks,No.6,No.7,No.8 came from HPLC fingerprint of Salvia miltiorrhiza and No.1 characteristic peaks,No.2,No.3,No.4 came from HPLC fingerprint of Panax notoginseng.CONCLUSION: The characteristic peaks of effective parts of Compound danshen tablet mainly come from S.miltiorrhiza.The study can be used for tracing and isolation of effective part of Compound danshen tablet and establishes basis for the further development of Chinese patent drugs.
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eng_Latn
| 32,199 |
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