README.md

metadata

title: Lu-177 Dosimetry Tool
emoji: ⚛️
colorFrom: indigo
colorTo: blue
sdk: gradio
sdk_version: 3.47.1
app_file: app.py
pinned: false

Lu-177 Dosimetry Tool (Two-Time-Point Fitting)

This open-source web application calculates Time-Integrated Activity (TIA) based on two post-treatment SPECT/CT time points using a mono-exponential washout model.

👨‍⚕️ Purpose

The tool is designed for simplified, patient-specific dosimetry of Lutetium-177–PSMA therapy in individuals diagnosed with metastatic castration-resistant prostate cancer (mCRPC). Its goal is to enable reliable dose estimation without complex imaging protocols.

📈 How It Works

Users provide:

• Two SPECT imaging time points (in hours)
• Corresponding activity measurements (in MBq)

The tool automatically:

• Fits a mono-exponential time–activity curve
• Calculates:
  • Washout rate (k)
  • Initial activity (A₀)
  • Time-Integrated Activity (TIA = A₀ / k)
• Displays results instantly

🧠 Model Used