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"No public implementation of the method is provided, which would be a nice extra" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"The paper is well-written, and easy to read and understand" "['pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro']" "paper quality"
"I think the effort of disentangling a complicated task into simpler ones makes sense , and the experiments have shown promising results" "['pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'non', 'non', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro']" "paper quality"
"In my view, the proposed methods are not completely novel , I think the authors are suggested to cite them, just name a few." "['non', 'non', 'non', 'non', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"The paper is very well written and easy to follow ; figure 1 does an excellent job at summarizing the method" "['pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'non', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro']" "paper quality"
"Could it be extended to work with only a fraction of the nuclei annotated ?" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'non']" "paper quality"
"Those three papers should be included in the state-of-the-art section : - Constrained convolutional neural networks for weakly supervised segmentation, Pathak et al., ICCV 2015 - DeepCut: Object Segmentation from Bounding Box Annotations using Convolutional Neural Networks, Rajchl et al., TMI, 2016 - Constrained-CNN losses for weakly supervised segmentation, Kervadec et al., MIDL 2018 Since the AJI and object-level Dice are not standard and introduced in other papers, it would be easier to put their formulation back in the paper, so the reader does not have to go look for it." "['non', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"There is no detail on qualitatively visual comparison of generated MR to ground truth" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"The authors had better compare segmentation result between CTP with orginal MRI and CTP with CGAN MRI" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"The gain using CGAN MRI looks marginal, which would be better to apply ablation study ." "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'non']" "paper quality"
"This work has a remarkable clinical value" "['pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro']" "paper quality"
"Clustering of aortic value prosthesis shapes has a high contribution to personalized medicine" "['pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro']" "paper quality"
"The introduction part is a little misleading for me" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"I'm concerned that this would make the readers misunderstand the data are shape-models (point cloud dataset) before the description of dataset in Sec. 2." "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"This study did not give a gold-standard for shape clustering (though it could be difficult)." "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non']" "paper quality"
"It is not convincing to claim that the clustering is correct since even a noise can be decoded into a normal image" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"other comments: - The authors use 2D images to represent leaflet shapes, I'm concerned whether 2D photograph is precise enough" "['non', 'non', 'non', 'non', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"3D scanner such as CT, MRI, optical scanner could be more suitable for this work" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"The paper is not well organized" "['con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"Details of training should be more clearly written" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"The hyper-parameters of autoencoder and the recon decoder should be more clearly stated for reproducibility" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"All architectures listed in Table 1 should be stated clearly in experiments section not only in method section ." "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'non']" "paper quality"
"It has the potential to improve pathology and cancer diagnosis by making it simpler and quicker The results of this work look visually convincing" "['pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro']" "paper quality"
"Both the de-speckle network and the GAN appear to deliver very good results, at least at first glance" "['pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro']" "paper quality"
"The quantitative results delivered by the de-speckling images, which seem to be computed using simulated realization of random speckle noise, look also convincing" "['pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro']" "paper quality"
"One issue, from a purely organizational standpoint, is the fact that information about previous work is either omitted or scattered around the text" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"This paper still represent a niche application of a more general DL technique that has been already used for a large number of similar applications" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"The contribution is therefore incremental, building on top of well-known techniques" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"Unfortunately the authors didn't report indications in this sense in their paper" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"The choice de-speckle network architecture is somewhat not sound, with the multiplicative residual connection near the outputs of the network and the median filtering operation" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"Is there some reference for multiplicative residual connections" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"How do we know that the network is learning 1/F (inverse of speckle noise)" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"Can we prove that at least visually" "['con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"Is the math right" "['con', 'con', 'con', 'con']" "paper quality"
"It is necessary to prove that the generated images retain their important diagnostic value" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"It is necessary to run a study to confirm that in a similar way that CM images were confirmed having diagnostic value and could therefore be used instead of H&E stained images" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"This will potentially bring us closer to rapid evaluation of lesions during surgical operation using fast CM" "['pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro']" "paper quality"
"2- Two step approach combining despeckling and generative networks are reasonable for the task" "['non', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro']" "paper quality"
"3- Qualitative stained image results look promising Cons: 1- Median filter is used after the despeckling network, however it is not clear the added benefit of using median filter in despeckling process" "['non', 'pro', 'pro', 'pro', 'pro', 'pro', 'pro', 'non', 'non', 'non', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"Error measures presented in Table 1 needs to help readers to identify the benefit of the proposed neural network" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"Even though it is mentioned by the authors that these images resemble to noisy RCM, this should be either referenced or shown" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"3- Please provide an evidence to support the positive effect of choosing an augmentation of size 512x512 after 50 epochs in Section 3.2." "['non', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'non', 'non']" "paper quality"
"4- The authors conclude that the despeckling NN is crucial to obtain realistic images, however, the results presented in Figures 8 and 9 do not provide enough information to support this conclusion" "['non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'non', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"The authors should provide support to these conclusions" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"For instance, Figure 9 needs to use the same images presented in Figure 8 to provide enough support for the need of despeckling network" "['non', 'non', 'non', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"In addition, images representing eliminated nuclei using noisy RCM images should be presented with their counterpart using despeckling network" "['non', 'non', 'non', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"5- Obtaining quantitative comparison results for staining accuracy is not feasible due to the reasons clearly defined by the authors" "['non', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"It is necessary to provide more qualitative information regarding the staining results in addition to confirmation from two expert pathologists" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"Please provide results of the inter-rater reliability of two pathologists using a point scale on the quality of image digital staining" "['con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"
"6- I suggest the authors to use train validation and test split or a cross-validation, since the results presented here are from a validation set without a test set" "['non', 'non', 'non', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con', 'con']" "paper quality"